The Use of Genomic Microarrays to Study Chromosomal Abnormalities in Mental Retardation

ERIC Educational Resources Information Center

Mao, Rong; Pevsner, Jonathan

2005-01-01

Mental retardation affects 2 to 3% of the US population. It is defined by broad criteria, including significantly subaverage intelligence, onset by age 18, and impaired function in a group of adaptive skills. A myriad of genetic and environmental causes have been described, but for approximately half of individuals diagnosed with mental…

The underlying structure of diagnostic systems of schizophrenia: a comprehensive polydiagnostic approach.

PubMed

Peralta, Victor; Cuesta, Manuel J

2005-11-15

The objective was to ascertain the underlying factor structure of alternative definitions of schizophrenia, and to examine the distribution of schizophrenia-related variables against the resulting factor solution. Twenty-three diagnostic schemes of schizophrenia were applied to 660 patients presenting with psychotic symptoms regardless of the specific diagnosis of psychotic disorder. Factor analysis of the 23 diagnostic schemes yielded three interpretable factors explaining 58% of the variance, the first factor (general schizophrenia factor) accounting for most of the variance (36%). On the basis of the general schizophrenia factor score, the sample was divided in quintile groups representing 5 levels of schizophrenia definition (absent, doubtful, very broad, broad and narrow) and the distribution of a number of schizophrenia-related variables was examined across the groups. This grouping procedure was used for examining the comparative validity of alternative levels of categorically defined schizophrenia and an ordinal (i.e. dimensional) definition. Overall, schizophrenia-related variables displayed a dose-response relationship with level of schizophrenia definition. Logistic regression analyses revealed that the dimensional definition explained more variance in the schizophrenia-related variables than the alternative levels for defining schizophrenia categorically. These results are consistent with a unitary and dimensional construct of schizophrenia with no clear "points of rarity" at its boundaries, thus supporting the continuum hypothesis of the psychotic illness.

Measuring Field-Normalized Impact of Papers on Specific Societal Groups: An Altmetrics Study Based on Mendeley Data

ERIC Educational Resources Information Center

Bornmann, Lutz; Haunschild, Robin

2017-01-01

Bibliometrics is successful in measuring impact because the target is clearly defined: the publishing scientist who is still active and working. Thus, citations are a target-oriented metric which measures impact on science. In contrast, societal impact measurements based on altmetrics are as a rule intended to measure impact in a broad sense on…

Updating the OMERACT filter: core areas as a basis for defining core outcome sets.

PubMed

Kirwan, John R; Boers, Maarten; Hewlett, Sarah; Beaton, Dorcas; Bingham, Clifton O; Choy, Ernest; Conaghan, Philip G; D'Agostino, Maria-Antonietta; Dougados, Maxime; Furst, Daniel E; Guillemin, Francis; Gossec, Laure; van der Heijde, Désirée M; Kloppenburg, Margreet; Kvien, Tore K; Landewé, Robert B M; Mackie, Sarah L; Matteson, Eric L; Mease, Philip J; Merkel, Peter A; Ostergaard, Mikkel; Saketkoo, Lesley Ann; Simon, Lee; Singh, Jasvinder A; Strand, Vibeke; Tugwell, Peter

2014-05-01

The Outcome Measures in Rheumatology (OMERACT) Filter provides guidelines for the development and validation of outcome measures for use in clinical research. The "Truth" section of the OMERACT Filter presupposes an explicit framework for identifying the relevant core outcomes that are universal to all studies of the effects of intervention effects. There is no published outline for instrument choice or development that is aimed at measuring outcome, was derived from broad consensus over its underlying philosophy, or includes a structured and documented critique. Therefore, a new proposal for defining core areas of measurement ("Filter 2.0 Core Areas of Measurement") was presented at OMERACT 11 to explore areas of consensus and to consider whether already endorsed core outcome sets fit into this newly proposed framework. Discussion groups critically reviewed the extent to which case studies of current OMERACT Working Groups complied with or negated the proposed framework, whether these observations had a more general application, and what issues remained to be resolved. Although there was broad acceptance of the framework in general, several important areas of construction, presentation, and clarity of the framework were questioned. The discussion groups and subsequent feedback highlighted 20 such issues. These issues will require resolution to reach consensus on accepting the proposed Filter 2.0 framework of Core Areas as the basis for the selection of Core Outcome Domains and hence appropriate Core Outcome Sets for clinical trials.

Attending to the role of race/ethnicity in family violence research.

PubMed

Malley-Morrison, Kathleen; Hines, Denise A

2007-08-01

Since the 1970s, researchers and public health and/or social policy communities have devoted increasing attention to family violence. Although officially reported crime figures for family violence appear to be declining, rates continue to be high in broadly defined racial and/or ethnic minority groups. More careful assessments of the potential role of race/ethnicity in family violence, and similarities and differences occurring across and within groups categorized based on race/ethnicity, are essential if adequate interventions are to be developed and utilized. This article provides suggestions on conducting better studies on family violence in the United States, particularly with respect to issues of race/ethnicity. The authors begin by considering conceptions and definitions of race/ethnicity and providing a broad definition of family violence. They then suggest issues for consideration at each stage of the research process, from reviewing previous research, to making methodological decisions, selecting samples, choosing measures, and analyzing and interpreting findings.

The pathophysiology of chronic constipation

PubMed Central

Andrews, Christopher N; Storr, Martin

2011-01-01

Constipation is broadly defined as an unsatisfactory defecation characterized by infrequent stools, difficult stool passage or both. The common approach to the pathophysiology of constipation groups the disorder into primary and secondary causes. Primary causes are intrinsic problems of colonic or anorectal function, whereas secondary causes are related to organic disease, systemic disease or medications. The normal process of colonic transit and defecation is discussed, and the etiology of constipation is reviewed. PMID:22114753

Anatomy of mole external genitalia: Setting the record straight

PubMed Central

Sinclair, Adriane Watkins; Glickman, Stephen; Baskin, Lawrence; Cunha, Gerald R.

2016-01-01

Anatomy of male and female external genitalia of adult mice (Mus musculus) and broad-footed moles (Scapanus latimanus) was re-examined to provide more meaningful anatomical terminology. In the past the perineal appendage of male broad-footed moles has been called the penis, while the female perineal appendage has been given several terms (e.g. clitoris, penile clitoris, peniform clitoris and others). Histological examination demonstrates that perineal appendages of male and female broad-footed moles are the prepuce, which in both sexes are covered externally with a hair-bearing epidermis and lacks erectile bodies. The inner preputial epithelium is non-hair-bearing and defines the preputial space in both sexes. The penis of broad-footed moles lies deep within the preputial space, is an “internal organ” in the resting state and contains the penile urethra, os penis, and erectile bodies. The clitoris of broad-footed moles is defined by a U-shaped clitoral epithelial lamina. Residing within clitoral stroma encompassed by the clitoral epithelial lamina is the corpus cavernosum, blood-filled spaces and the urethra. External genitalia of male and female mice are anatomically similar to that of broad-footed moles with the exception that in female mice the clitoris contains a small os clitoridis and lacks defined erectile bodies, while male mice have an os penis and a prominent distal cartilaginous structure within the male urogenital mating protuberance (MUMP). Clitori of female broad-footed moles lack an os clitoridis but contain defined erectile bodies, while male moles have an os penis similar to the mouse but lack the distal cartilaginous structure. PMID:26694958

Potential Adverse Effects of Broad-Spectrum Antimicrobial Exposure in the Intensive Care Unit.

PubMed

Wiens, Jenna; Snyder, Graham M; Finlayson, Samuel; Mahoney, Monica V; Celi, Leo Anthony

2018-02-01

The potential adverse effects of empiric broad-spectrum antimicrobial use among patients with suspected but subsequently excluded infection have not been fully characterized. We sought novel methods to quantify the risk of adverse effects of broad-spectrum antimicrobial exposure among patients admitted to an intensive care unit (ICU). Among all adult patients admitted to ICUs at a single institution, we selected patients with negative blood cultures who also received ≥1 broad-spectrum antimicrobials. Broad-spectrum antimicrobials were categorized in ≥1 of 5 categories based on their spectrum of activity against potential pathogens. We performed, in serial, 5 cohort studies to measure the effect of each broad-spectrum category on patient outcomes. Exposed patients were defined as those receiving a specific category of broad-spectrum antimicrobial; nonexposed were all other patients in the cohort. The primary outcome was 30-day mortality. Secondary outcomes included length of hospital and ICU stay and nosocomial acquisition of antimicrobial-resistant bacteria (ARB) or Clostridium difficile within 30 days of admission. Among the study cohort of 1918 patients, 316 (16.5%) died within 30 days, 821 (42.8%) had either a length of hospital stay >7 days or an ICU length of stay >3 days, and 106 (5.5%) acquired either a nosocomial ARB or C. difficile . The short-term use of broad-spectrum antimicrobials in any of the defined broad-spectrum categories was not significantly associated with either primary or secondary outcomes. The prompt and brief empiric use of defined categories of broad-spectrum antimicrobials could not be associated with additional patient harm.

Broad-Range 16S rDNA PCR on Heart Valves in Infective Endocarditis.

PubMed

Müller Premru, Manica; Lejko Zupanc, Tatjana; Klokočovnik, Tomislav; Ruzić Sabljić, Eva; Cerar, Tjaša

2016-03-01

Infective endocarditis (IE) is diagnosed by blood and/or resected valve cultivation and echocardiographic findings, as defined by the Duke criteria. Unfortunately, cultures may be negative due to prior antibiotic therapy or fastidious or slow-growing microorganisms. The study aim was to investigate the value of the broad-range polymerase chain reaction (PCR) in addition to blood and valve culture for the detection of causative microorganisms. Between February 2012 and March 2015, valve samples from 36 patients undergoing cardiac surgery were analyzed; of these patients, 26 had a preoperative diagnosis of IE and 10 served as controls. Multiple blood cultures were obtained from 34 patients before antibiotic therapy was commenced. Valve samples were inoculated on bacteriological media and underwent analysis using broad-range PCR (16S rDNA). IE was confirmed microbiologically in 21 of the 26 patients (80.7%); in 20 cases (76.9%) this was by positive blood cultures and in 16 (61.5%) by positive valves. Valves were positive in 15 blood culturepositive patients, and in one blood-culture negative patient. Broad-range PCR detected a microorganism in valves significantly more frequently (n = 14; 53.8%) compared to valve culture (n = 8; 30.7%) (chisquare 11.5, p <0.001). The predominant microorganisms were Staphylococcus aureus, Streptococcus of the viridans group, coagulasenegative staphylococci and Enterococcus faecalis. Blood, valve cultures and broad-range PCR were negative in five patients (19.3%) with IE, and in all 10 subjects of the control group. Broad-range PCR on valves was more sensitive than valve culture. However, blood culture, if taken before the start of antibiotic therapy, was the best method for detecting IE.

Genomics of Probiotic Bacteria

NASA Astrophysics Data System (ADS)

O'Flaherty, Sarah; Goh, Yong Jun; Klaenhammer, Todd R.

Probiotic bacteria from the Lactobacillus and Bifidobacterium species belong to the Firmicutes and the Actinobacteria phylum, respectively. Lactobacilli are members of the lactic acid bacteria (LAB) group, a broadly defined family of microorganisms that ferment various hexoses into primarily lactic acid. Lactobacilli are typically low G + C gram-positive species which are phylogenetically diverse, with over 100 species documented to date. Bifidobacteria are heterofermentative, high G + C content bacteria with about 30 species of bifidobacteria described to date.

"Dermatitis" defined.

PubMed

Smith, Suzanne M; Nedorost, Susan T

2010-01-01

The term "dermatitis" can be defined narrowly or broadly, clinically or histologically. A common and costly condition, dermatitis is underresourced compared to other chronic skin conditions. The lack of a collectively understood definition of dermatitis and its subcategories could be the primary barrier. To investigate how dermatologists define the term "dermatitis" and determine if a consensus on the definition of this term and other related terms exists. A seven-question survey of dermatologists nationwide was conducted. Of respondents (n  =  122), half consider dermatitis to be any inflammation of the skin. Nearly half (47.5%) use the term interchangeably with "eczema." Virtually all (> 96%) endorse the subcategory "atopic" under the terms "dermatitis" and "eczema," but the subcategories "contact," "drug hypersensitivity," and "occupational" are more highly endorsed under the term "dermatitis" than under the term "eczema." Over half (55.7%) personally consider "dermatitis" to have a broad meaning, and even more (62.3%) believe that dermatologists as a whole define the term broadly. There is a lack of consensus among experts in defining dermatitis, eczema, and their related subcategories.

Conservation science for marine megafauna in Europe: Historical perspectives and future directions

NASA Astrophysics Data System (ADS)

Authier, M.; Spitz, J.; Blanck, A.; Ridoux, V.

2017-07-01

A broad range of marine species have been named as marine megafauna, however providing a precise definition of this term is difficult. It is not a taxonomically defined group, as it includes sea mammals, birds, reptiles, large fish and elasmobranchs (Fig. 1). Overall, marine megafauna species are large vertebrates that depend on marine resources for their food. These mobile species are generally at the top of their trophic food webs and have none or few predators. From the tiny storm-petrel to the gigantic blue whale, this group is biologically diverse and brings together species which cannot be strictly defined by morphological or physiological similarities. Rather, our perception of marine megafauna as a coherent group is based on ecological similarities and shared conservation issues. These species are exposed to similar threats and generally show limited resilience due to their intrinsic life history traits such as low fecundity rates and high longevity. Consequently, they share common conservation challenges (e.g. Hooker and Gerber, 2004; Lascelles et al., 2014).

Potential Adverse Effects of Broad-Spectrum Antimicrobial Exposure in the Intensive Care Unit

PubMed Central

Wiens, Jenna; Finlayson, Samuel; Mahoney, Monica V; Celi, Leo Anthony

2018-01-01

Abstract Background The potential adverse effects of empiric broad-spectrum antimicrobial use among patients with suspected but subsequently excluded infection have not been fully characterized. We sought novel methods to quantify the risk of adverse effects of broad-spectrum antimicrobial exposure among patients admitted to an intensive care unit (ICU). Methods Among all adult patients admitted to ICUs at a single institution, we selected patients with negative blood cultures who also received ≥1 broad-spectrum antimicrobials. Broad-spectrum antimicrobials were categorized in ≥1 of 5 categories based on their spectrum of activity against potential pathogens. We performed, in serial, 5 cohort studies to measure the effect of each broad-spectrum category on patient outcomes. Exposed patients were defined as those receiving a specific category of broad-spectrum antimicrobial; nonexposed were all other patients in the cohort. The primary outcome was 30-day mortality. Secondary outcomes included length of hospital and ICU stay and nosocomial acquisition of antimicrobial-resistant bacteria (ARB) or Clostridium difficile within 30 days of admission. Results Among the study cohort of 1918 patients, 316 (16.5%) died within 30 days, 821 (42.8%) had either a length of hospital stay >7 days or an ICU length of stay >3 days, and 106 (5.5%) acquired either a nosocomial ARB or C. difficile. The short-term use of broad-spectrum antimicrobials in any of the defined broad-spectrum categories was not significantly associated with either primary or secondary outcomes. Conclusions The prompt and brief empiric use of defined categories of broad-spectrum antimicrobials could not be associated with additional patient harm. PMID:29479546

Pharmacy sales data versus ward stock accounting for the surveillance of broad-spectrum antibiotic use in hospitals

PubMed Central

2011-01-01

Background Antibiotic consumption in hospitals is commonly measured using the accumulated amount of drugs delivered from the pharmacy to ward held stocks. The reliability of this method, particularly the impact of the length of the registration periods, has not been evaluated and such evaluation was aim of the study. Methods During 26 weeks, we performed a weekly ward stock count of use of broad-spectrum antibiotics - that is second- and third-generation cephalosporins, carbapenems, and quinolones - in five hospital wards and compared the data with corresponding pharmacy sales figures during the same period. Defined daily doses (DDDs) for antibiotics were used as measurement units (WHO ATC/DDD classification). Consumption figures obtained with the two methods for different registration intervals were compared by use of intraclass correlation analysis and Bland-Altman statistics. Results Broad-spectrum antibiotics accounted for a quarter to one-fifth of all systemic antibiotics (ATC group J01) used in the hospital and varied between wards, from 12.8 DDDs per 100 bed days in a urological ward to 24.5 DDDs in a pulmonary diseases ward. For the entire study period of 26 weeks, the pharmacy and ward defined daily doses figures for all broad-spectrum antibiotics differed only by 0.2%; however, for single wards deviations varied from -4.3% to 6.9%. The intraclass correlation coefficient, pharmacy versus ward data, increased from 0.78 to 0.94 for parenteral broad-spectrum antibiotics with increasing registration periods (1-4 weeks), whereas the corresponding figures for oral broad-spectrum antibiotics (ciprofloxacin) were from 0.46 to 0.74. For all broad-spectrum antibiotics and for parenteral antibiotics, limits of agreement between the two methods showed, according to Bland-Altman statistics, a deviation of ± 5% or less from average mean DDDs at 3- and 4-weeks registration intervals. Corresponding deviation for oral antibiotics was ± 21% at a 4-weeks interval. Conclusions There is a need for caution in interpreting pharmacy sales data aggregated over short registration intervals, especially so for oral formulations. Even a one-month registration period may be too short. PMID:22166018

Pharmacy sales data versus ward stock accounting for the surveillance of broad-spectrum antibiotic use in hospitals.

PubMed

Haug, Jon B; Myhr, Randi; Reikvam, Asmund

2011-12-13

Antibiotic consumption in hospitals is commonly measured using the accumulated amount of drugs delivered from the pharmacy to ward held stocks. The reliability of this method, particularly the impact of the length of the registration periods, has not been evaluated and such evaluation was aim of the study. During 26 weeks, we performed a weekly ward stock count of use of broad-spectrum antibiotics--that is second- and third-generation cephalosporins, carbapenems, and quinolones--in five hospital wards and compared the data with corresponding pharmacy sales figures during the same period. Defined daily doses (DDDs) for antibiotics were used as measurement units (WHO ATC/DDD classification). Consumption figures obtained with the two methods for different registration intervals were compared by use of intraclass correlation analysis and Bland-Altman statistics. Broad-spectrum antibiotics accounted for a quarter to one-fifth of all systemic antibiotics (ATC group J01) used in the hospital and varied between wards, from 12.8 DDDs per 100 bed days in a urological ward to 24.5 DDDs in a pulmonary diseases ward. For the entire study period of 26 weeks, the pharmacy and ward defined daily doses figures for all broad-spectrum antibiotics differed only by 0.2%; however, for single wards deviations varied from -4.3% to 6.9%. The intraclass correlation coefficient, pharmacy versus ward data, increased from 0.78 to 0.94 for parenteral broad-spectrum antibiotics with increasing registration periods (1-4 weeks), whereas the corresponding figures for oral broad-spectrum antibiotics (ciprofloxacin) were from 0.46 to 0.74. For all broad-spectrum antibiotics and for parenteral antibiotics, limits of agreement between the two methods showed, according to Bland-Altman statistics, a deviation of ± 5% or less from average mean DDDs at 3- and 4-weeks registration intervals. Corresponding deviation for oral antibiotics was ± 21% at a 4-weeks interval. There is a need for caution in interpreting pharmacy sales data aggregated over short registration intervals, especially so for oral formulations. Even a one-month registration period may be too short.

The State as Community in Community-based Participatory Research

PubMed Central

Goold, Susan Dorr; Rowe, Zachary; Szymecko, Lisa; Coombe, Chris; Danis, Marion; Hammad, Adnan; Calhoun, Karen; Salman, Cengiz

2017-01-01

Background Community-based participatory research (CBPR) typically defines communities by geography, ethnicity, shared health needs, or some combination. Objectives We describe a CBPR project aiming to engage diverse minority and underserved communities throughout Michigan in deliberations about health research priorities. Methods A Steering Committee (SC) with 15 members from minority and underserved communities, and 4 members from research organizations led the project, with the help of regional advisory groups (RAGs) formed at the SC’s request. Evaluation of the SC used questionnaires, focused group discussion, and review of SC meetings to describe engagement, partnership, and communication. Lessons Learned An academic-community partnership with a diverse, dispersed and broadly defined community found value in RAGs, dedicated academic staff, face-to-face meetings, varied communication modalities, capacity building tailored to varying levels of CBPR experience, and ongoing evaluation. Conclusions A geographically and culturally diverse partnership presents challenges and opportunities in representativeness, relationship building, capacity building, and communication. PMID:28569676

[Beyond the indigenous: health and interculturality at the global level].

PubMed

Knipper, Michael

2010-03-01

Health inequalities are broadly documented for ethnic minority groups and immigrants worldwide. Intercultural perspectives in health are thus developed in very different places and situations. Both the criteria for defining the target groups as well as the ways the health problems of these groups are looked at, are shaped by the particular local context. However, some challenges are common to almost all situations where the topic of ethnic diversity and health is considered. And in contrast to the rather novel term, the issues at stake in "intercultural heath" are not new at all. Against this background, the present article brings into focus three essential points: the necessity of defining ethnicity adequately to avoid stereotyping and the creation of new inequalities; the challenge of converting ethnicity into a helpful and thus "healthy" category in the field of medicine and health; and the need for the integration of explicit and serious reflections on medical ethics and human rights that provide for the normative framework and moral orientation of health activities with indigenous, migrant and other particularly vulnerable groups.

A pH-tunable nanofluidic diode with a broad range of rectifying properties.

PubMed

Ali, Mubarak; Ramirez, Patricio; Mafé, Salvador; Neumann, Reinhard; Ensinger, Wolfgang

2009-03-24

The use of fixed charge nanopores in practical applications requires tuning externally the electrostatic interaction between the charged groups and the ionic permeants in order to allow integrating a variety of functions on the same nanostructure. We design, produce, and characterize, theoretically and experimentally, a single-track amphoteric nanopore functionalized with lysine and histidine chains whose positive and negative charges are very sensitive to the external pH. This nanofluidic diode with amphoteric chains attached to the pore surface allows for a broad set of rectification properties supported by a single nanodevice. A definite plus is to functionalize these groups on a conical nanopore with well-defined, controlled structural asymmetry which gives virtually every rectification characteristic that may be required in practical applications. Nanometerscaled amphoteric pores are of general interest because of the potential applications in drug delivery systems, ion-exchange membranes for separation of biomacromolecules, antifouling materials with reduced molecular adsorption, and biochemical sensors.

The National Occupational Research Agenda: a model of broad stakeholder input into priority setting.

PubMed Central

Rosenstock, L; Olenec, C; Wagner, G R

1998-01-01

OBJECTIVES: No single organization has the resources necessary to conduct occupational safety and health research to adequately serve the needs of workers in the United States. The National Institute for Occupational Safety and Health (NIOSH) undertook the task of setting research priorities in response to a broadly perceived need to systematically address those topics most pressing and most likely to yield gains to workers and to the nation. METHODS: NIOSH and its public and private partners used a consensus-building process to set priorities for the next decade for occupational safety and health research--the National Occupational Research Agenda. RESULTS: The process resulted in the identification of 21 research priorities grouped into 3 categories: disease and injury, work environment and workforce, and research tools and approaches. CONCLUSIONS: Although the field of occupational safety and health is often contentious and adversarial, these research priorities reflect a remarkable degree of concurrence among a broad range of stakeholders who provided input into a clearly defined and open process. PMID:9518963

Civil Rights Laws as Tools to Advance Health in the Twenty-First Century.

PubMed

McGowan, Angela K; Lee, Mary M; Meneses, Cristina M; Perkins, Jane; Youdelman, Mara

2016-01-01

To improve health in the twenty-first century, to promote both access to and quality of health care services and delivery, and to address significant health disparities, legal and policy approaches, specifically those focused on civil rights, could be used more intentionally and strategically. This review describes how civil rights laws, and their implementation and enforcement, help to encourage health in the United States, and it provides examples for peers around the world. The review uses a broad lens to define health for both classes of individuals and their communities--places where people live, learn, work, and play. Suggestions are offered for improving health and equity broadly, especially within societal groups and marginalized populations. These recommendations include multisectorial approaches that focus on the social determinants of health.

Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group a streptococcal vaccines.

PubMed

Moyle, Peter M; Dai, Wei; Zhang, Yingkai; Batzloff, Michael R; Good, Michael F; Toth, Istvan

2014-05-21

Subunit vaccines offer a means to produce safer, more defined vaccines compared to traditional whole microorganism approaches. Subunit antigens, however, exhibit weak immunity, which is normally overcome through coadministration with adjuvants. Enhanced vaccine properties (e.g., improved potency) can be obtained by linking antigen and adjuvant, as observed for synthetic peptide antigens and Toll-like receptor 2 (TLR2) ligands. As few protective peptide antigens have been reported, compared to protein antigens, we sought to extend the utility of this approach to recombinant proteins, while ensuring that conjugation reactions yielded a single, molecularly defined product. Herein we describe the development and optimization of techniques that enable the efficient, site-specific attachment of three synthetic TLR2 ligands (lipid core peptide (LCP), Pam2Cys, and Pam3Cys) onto engineered protein antigens, permitting the selection of optimal TLR2 agonists during the vaccine development process. Using this approach, broadly protective (J14) and population targeted (seven M protein N-terminal antigens) multiantigenic vaccines against group A streptococcus (GAS; Streptococcus pyogenes) were produced and observed to self-assemble in PBS to yield nanoparticules (69, 101, and 123 nm, respectively). All nanoparticle formulations exhibited self-adjuvanting properties, with rapid, persistent, antigen-specific IgG antibody responses elicited toward each antigen in subcutaneously immunized C57BL/6J mice. These antibodies were demonstrated to strongly bind to the cell surface of five GAS serotypes that are not represented by vaccine M protein N-terminal antigens, are among the top 20 circulating strains in developed countries, and are associated with clinical disease, suggesting that these vaccines may elicit broadly protective immune responses.

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

PubMed Central

Hamshere, M. L.; Green, E. K.; Jones, I. R.; Jones, L.; Moskvina, V.; Kirov, G.; Grozeva, D.; Nikolov, I.; Vukcevic, D.; Caesar, S.; Gordon-Smith, K.; Fraser, C.; Russell, E.; Breen, G.; St Clair, D.; Collier, D. A.; Young, A. H.; Ferrier, I. N.; Farmer, A.; McGuffin, P.; Holmans, P. A.; Owen, M. J.; O’Donovan, M. C.; Craddock, N.

2009-01-01

Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological–genetic research. Aims To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case–control bipolar disorder sample. Method We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, comprising 1868 individuals with bipolar disorder and 2938 controls genotyped for 276 122 single nucleotide polymorphisms (SNPs) that met stringent criteria for genotype quality. For each SNP we performed a test of association (bipolar disorder group v. control group) and used the number of associated independent SNPs statistically significant at P<0.00001 as a metric for the overall genetic signal in the sample. We next compared this metric with that obtained using each of seven diagnostic subsets of the group with bipolar disorder: Research Diagnostic Criteria (RDC): bipolar I disorder; manic disorder; bipolar II disorder; schizoaffective disorder, bipolar type; DSM–IV: bipolar I disorder; bipolar II disorder; schizoaffective disorder, bipolar type. Results The RDC schizoaffective disorder, bipolar type (v. controls) stood out from the other diagnostic subsets as having a significant excess of independent association signals (P<0.003) compared with that expected in samples of the same size selected randomly from the total bipolar disorder group data-set. The strongest association in this subset of participants with bipolar disorder was at rs4818065 (P = 2.42×10–7). Biological systems implicated included gamma amniobutyric acid (GABA)A receptors. Genes having at least one associated polymorphism at P<10–4 included B3GALTS, A2BP1, GABRB1, AUTS2, BSN, PTPRG, GIRK2 and CDH12. Conclusions Our findings show that individuals with broadly defined bipolar schizoaffective features have either a particularly strong genetic contribution or that, as a group, are genetically more homogeneous than the other phenotypes tested. The results point to the importance of using diagnostic approaches that recognise this group of individuals. Our approach can be applied to similar data-sets for other psychiatric and non-psychiatric phenotypes. PMID:19567891

Fat Analysis

NASA Astrophysics Data System (ADS)

Min, David B.; Ellefson, Wayne C.

Lipids, proteins, and carbohydrates constitute the principal structural components of foods. Lipids are a group of substances that, in general, are soluble in ether, chloroform, or other organic solvents but are sparingly soluble in water. However, there exists no clear scientific definition of a lipid, primarily due to the water solubility of certain molecules that fall within one of the variable categories of food lipids (1). Some lipids, such as triacylglycerols, are very hydrophobic. Other lipids, such as di- and monoacylglycerols, have both hydrophobic and hydrophilic moieties in their molecules and are soluble in relatively polar solvents (2). Short-chain fatty acids such as C1-C4 are completely miscible in water and insoluble in nonpolar solvents (1). The most widely accepted definition is based on solubility as previously stated. While most macromolecules are characterized by common structural features, the designation of "lipid" being defined by solubility characteristics is unique to lipids (2). Lipids comprise a broad group of substances that have some common properties and compositional similarities (3). Triacylglycerols are fats and oils that represent the most prevalent category of the group of compounds known as lipids. The terms lipids, fats, and oils are often used interchangeably. The term "lipid" commonly refers to the broad, total collection of food molecules that meet the definition previously stated. Fats generally refer to those lipids that are solid at room temperature and oils generally refer to those lipids that are liquid at room temperature. While there may not be an exact scientific definition, the US Food and Drug Administration (FDA) has established a regulatory definition for nutrition labeling purposes. The FDA has defined total fat as the sum of fatty acids from C4 to C24, calculated as triglycerides. This definition provides a clear path for resolution of any nutrition labeling disputes.

The human biology of Jim Tanner.

PubMed

Cameron, Noël

2012-09-01

In 1940, during his second year of medical training, Jim Tanner expressed the desire to work, 'where physiology, psychology and sociology meet'. His subsequent exposure to the breadth of an American medical education and to the social and economic environment of post-war Europe distilled his belief in the importance of viewing the human in a broad context. Following his visits to the American longitudinal growth studies in 1948. Jim's dreams of a broad scientific discipline that incorporated both the biology and ecology of the human were strengthened by an inspirational group of embryonic human biologists with whom he developed '… the new Human Biology …' from the '… Physical Anthropology of old…'. With Jo Weiner, Derek Roberts, Geoffrey Harrison, Arthur Mourant, Nigel Barnicot and Kenneth Oakley, Jim was to form the Society for the Study of Human Biology in 1958. The development of human biology over the next 50 years was shaped by the expertise and diversity of that group of visionary scientists who conceived the scientific discipline of 'human biology' in which biology, behaviour and social context define the human species.

Vibrons in finite size molecular lattices: a route for high-fidelity quantum state transfer at room temperature.

PubMed

Pouthier, Vincent

2012-11-07

A communication protocol is proposed in which vibron-mediated quantum state transfer takes place in a molecular lattice. We consider two distant molecular groups grafted on each side of the lattice. These groups form two quantum computers where vibrational qubits are implemented and received. The lattice defines the communication channel along which a vibron delocalizes and interacts with a phonon bath. Using quasi-degenerate perturbation theory, vibron-phonon entanglement is taken into account through the effective Hamiltonian concept. A vibron is thus dressed by a virtual phonon cloud whereas a phonon is clothed by virtual vibronic transitions. It is shown that three quasi-degenerate dressed states define the relevant paths followed by a vibron to tunnel between the computers. When the coupling between the computers and the lattice is judiciously chosen, constructive interference takes place between these paths. Phonon-induced decoherence is minimized and a high-fidelity quantum state transfer occurs over a broad temperature range.

Determinants of individual and group performance

NASA Technical Reports Server (NTRS)

Helmreich, Robert L.

1986-01-01

A broad exploration of individual and group/organizational factors that influence performance in demanding environments such as space and air transport was undertaken. Primary efforts were directed toward defining critical issues, developing new methodologies for the assessment of performance in such environments, and developing new measures of personality and attitudes as predictors of performance. Substantial clarification of relevant issues for research and validation was achieved. A reliable instrument to assess crewmembers' attitudes regarding crew coordination and flightdeck management was validated. Major efforts in data collection to validate concepts were initiated. The results suggest that substantial improvements can be made in the prediction of performance and in the selection of crewmembers for aviation and space.

Cultural diversity and transcultural nursing as they impact health care.

PubMed

Clark, C; Robinson, T M

1999-01-01

This article examines and critiques what can be broadly defined as "culturally sensitive nursing practice." The authors argue that both past and present research on culturally sensitive nursing practice, regardless of which branch of such practice it subscribes to (transcultural, cross-cultural, multicultural, intercultural, international, and so forth), is not sufficiently based in a sociopolitical context. As a result, there is not significant positive improvement in health care outcomes for patients from traditionally under-represented social membership groups (i.e., groups based on race, gender, socioeconomic class, etc.). Realizing sincere and affective culturally sensitive nursing practice is contingent upon the development and implementation of a comprehensive, sociopolitically conceptualized multicultural nursing education curriculum and pedagogy.

'The full has never been told': building a theory of sexual health for heterosexual Black men of Caribbean descent.

PubMed

Crowell, Candice N; Delgado-Romero, Edward A; Mosley, Della V; Huynh, Sophia

2016-08-01

Research on Black sexual health often fails to represent the heterogeneity of Black ethnic groups. For people of Caribbean descent in the USA, ethnicity is a salient cultural factor that influences definitions and experiences of sexual health. Most research on people of Caribbean descent focuses on the relatively high rate of STIs, but sexual health is defined more broadly than STI prevalence. Psychological and emotional indicators and the voice of participants are important to consider when exploring the sexual health of a minority culture. The purpose of this study was to qualitatively explore how heterosexual Black men of Caribbean descent define and understand sexual health for themselves. Eleven men who self-identified as Black, Caribbean and heterosexual participated in three focus groups and were asked to define sexual health, critique behaviours expertly identified as healthy and address what encourages and discourages sexual health in their lives. Findings point to six dimensions of sexual health for heterosexual Black men of Caribbean descent. These include: heterosexually privileged, protective, contextual, interpersonal, cultural and pleasurable dimensions. There were some notable departures from current expert definitions of sexual health. Recommendations for further theory development are provided.

Taking Stock of Unrealistic Optimism.

PubMed

Shepperd, James A; Klein, William M P; Waters, Erika A; Weinstein, Neil D

2013-07-01

Researchers have used terms such as unrealistic optimism and optimistic bias to refer to concepts that are similar but not synonymous. Drawing from three decades of research, we critically discuss how researchers define unrealistic optimism and we identify four types that reflect different measurement approaches: unrealistic absolute optimism at the individual and group level and unrealistic comparative optimism at the individual and group level. In addition, we discuss methodological criticisms leveled against research on unrealistic optimism and note that the criticisms are primarily relevant to only one type-the group form of unrealistic comparative optimism. We further clarify how the criticisms are not nearly as problematic even for unrealistic comparative optimism as they might seem. Finally, we note boundary conditions on the different types of unrealistic optimism and reflect on five broad questions that deserve further attention.

Defining and understanding healthy lifestyles choices for adolescents.

PubMed

He, Ka; Kramer, Ellen; Houser, Robert F; Chomitz, Virginia R; Hacker, Karen A

2004-07-01

To: (a) establish criteria for defining positive health behaviors and lifestyle; and (b) identify characteristics of adolescents who practice a healthy lifestyle. Responses from a 1998 survey via questionnaire, of 1487 students, from a public high school, Cambridge, Massachusetts, were used to assess correlates of healthy lifestyle choices. Strict and broad assessments of healthy behaviors were defined for students: use of alcohol, tobacco, and illegal drugs; sexual behavior; attempted suicide. Whereas the "strict" criteria included only those adolescents who did not practice any of the behaviors in question, the broad criteria reflected experimentation and moderate risk-taking. The prevalence of positive behaviors was assessed by demographic and student characteristics. In addition, logistic regression models were created to predict determinants of teenagers' healthy lifestyles using both strict and broad definitions. Using strict criteria of healthy lifestyle, significant predictors were being female, born outside the United States, higher academic performance, and fewer stressful life events. Using a broad definition of a healthy lifestyle, significant predictors were being non-Caucasian, in the lower grade levels at the school, higher academic performance, and fewer stressful life events. In both models, peers' approval of risky behaviors negatively influenced teens' lifestyles, whereas parents' disapproval of risky behaviors was a positive influence. These results reinforce the importance of school, peer, and parent support of positive behaviors. It is important for public health workers and families to understand and define healthy lifestyles choices for adolescents.

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection Against Ebolaviruses

DTIC Science & Technology

2017-03-31

GP proteins from EBOV, BDBV, and SUDV by ELISA . We found that 72% of the mAbs were also able to recognize BDBV GP, whereas only 11% demonstrated...349 mAbs reacted with all three ebolavirus glycoproteins by ELISA (Figure S1B). Within this subset, 16 mAbs belonged to the glycan cap epitope group...Miller et al., 2012; Wang et al., 2016), we first examined the capacity of the GP base-binding NAbs to inhibit it in a competitive ELISA (Figure 5A

Geology and ore deposits of the Philipsburg quadrangle, Montana

USGS Publications Warehouse

Emmons, William Harvey; Calkins, Frank Cathcart

1913-01-01

Philipsburg lies about midway between the eastern and western limits of the Rocky Mountain system, if the term be used in the broad sense prevailing in the United States. In the general latitude of Montana the system as defined by American usage is bounded on the west by the Columbia River basalt plain and on the east by the Great Plains. The western limit is fairly definite, but on the east there is no very definite line between the plains and mountains; the mountains are fairly continuous west and north of the Philipsburg quadrangle, but to the east and southeast mountains alternate with broad stretches of semiarid lowland. The quadrangle therefore overlaps the line between two physiographic provinces, one characterized by isolated mountain groups, of which the Flint Creek Range is the most westerly, and the other by more continuous elevations, of which the Sapphire Mountains are an example.

Declines in Outpatient Antimicrobial Use in Canada (1995–2010)

PubMed Central

Finley, Rita; Glass-Kaastra, Shiona K.; Hutchinson, Jim; Patrick, David M.; Weiss, Karl; Conly, John

2013-01-01

Background With rising reports of antimicrobial resistance in outpatient communities, surveillance of antimicrobial use is imperative for supporting stewardship programs. The primary objective of this article is to assess the levels of antimicrobial use in Canada over time. Methods Canadian antimicrobial use data from 1995 to 2010 were acquired and assessed by four metrics: population-adjusted prescriptions, Defined Daily Doses, spending on antimicrobials (inflation-adjusted), and average Defined Daily Doses per prescription. Linear mixed models were built to assess significant differences among years and antimicrobial groups, and to account for repeated measurements over time. Measures were also compared to published reports from European countries. Results Temporal trends in antimicrobial use in Canada vary by metric and antimicrobial grouping. Overall reductions were seen for inflation-adjusted spending, population-adjusted prescription rates and Defined Daily Doses, and increases were observed for the average number of Defined Daily Doses per prescription. The population-adjusted prescription and Defined Daily Doses values for 2009 were comparable to those reported by many European countries, while the average Defined Daily Dose per prescription for Canada ranked high. A significant reduction in the use of broad spectrum penicillins occurred between 1995 and 2004, coupled with increases in macrolide and quinolone use, suggesting that replacement of antimicrobial drugs may occur as new products arrive on the market. Conclusions There have been modest decreases of antimicrobial use in Canada over the past 15 years. However, continued surveillance of antimicrobial use coupled with data detailing antimicrobial resistance within bacterial pathogens affecting human populations is critical for targeting interventions and maintaining the effectiveness of these products for future generations. PMID:24146863

Color and Streptomycetes1

PubMed Central

Pridham, Thomas G.

1965-01-01

A report summarizing the results of an international workshop on determination of color of streptomycetes is presented. The results suggest that the color systems which seem most practically appealing and effective to specialists on actinomycetes are those embracing a limited number of color names and groups. The broad groupings allow placement of isolates into reasonably well-defined categories based on color of aerial mycelium. Attempts to expand such systems (more color groups) lead to difficulties. It is common knowledge that many, if not all, of the individual groups would in these broad systems contain strains that differ in many other respects, e.g., spore-wall ornamentation, color of vegetative (substratal) mycelium, morphology of chains of spores, and numerous physiological criteria. Also, cultures of intermediate color can be found, which makes placement difficult. As it now stands, color as a criterion for characterization of streptomycetes and streptoverticillia is in questionable status. Although much useful color information can be obtained by an individual, the application of this information to that in the literature or its use in communication with other individuals leaves much to be desired. More objective methods of color determination are needed. At present, the most effective method that could be used internationally is the color-wheel system of Tresner and Backus. Furthermore, the significance of color in speciation of these organisms is an open question. Obviously, more critical work on the color problem is needed. PMID:14264847

40Ar/39Ar geochronology, paleomagnetism, and evolution of the Boring volcanic field, Oregon and Washington, USA

USGS Publications Warehouse

Fleck, Robert J.; Hagstrum, Jonathan T.; Calvert, Andrew T.; Evarts, Russell C.; Conrey, Richard M.

2014-01-01

The 40Ar/39Ar investigations of a large suite of fine-grained basaltic rocks of the Boring volcanic field (BVF), Oregon and Washington (USA), yielded two primary results. (1) Using age control from paleomagnetic polarity, stratigraphy, and available plateau ages, 40Ar/39Ar recoil model ages are defined that provide reliable age results in the absence of an age plateau, even in cases of significant Ar redistribution. (2) Grouping of eruptive ages either by period of activity or by composition defines a broadly northward progression of BVF volcanism during latest Pliocene and Pleistocene time that reflects rates consistent with regional plate movements. Based on the frequency distribution of measured ages, periods of greatest volcanic activity within the BVF occurred 2.7–2.2 Ma, 1.7–0.5 Ma, and 350–50 ka. Grouped by eruptive episode, geographic distributions of samples define a series of northeast-southwest–trending strips whose centers migrate from south-southeast to north-northwest at an average rate of 9.3 ± 1.6 mm/yr. Volcanic activity in the western part of the BVF migrated more rapidly than that to the east, causing trends of eruptive episodes to progress in an irregular, clockwise sense. The K2O and CaO values of dated samples exhibit well-defined temporal trends, decreasing and increasing, respectively, with age of eruption. Divided into two groups by K2O, the centers of these two distributions define a northward migration rate similar to that determined from eruptive age groups. This age and compositional migration rate of Boring volcanism is similar to the clockwise rotation rate of the Oregon Coast Range with respect to North America, and might reflect localized extension on the trailing edge of that rotating crustal block.

Comparison of Hyperspectral and Multispectral Satellites for Forest Alliance Classification in the San Francisco Bay Area

NASA Astrophysics Data System (ADS)

Clark, M. L.

2016-12-01

The goal of this study was to assess multi-temporal, Hyperspectral Infrared Imager (HyspIRI) satellite imagery for improved forest class mapping relative to multispectral satellites. The study area was the western San Francisco Bay Area, California and forest alliances (e.g., forest communities defined by dominant or co-dominant trees) were defined using the U.S. National Vegetation Classification System. Simulated 30-m HyspIRI, Landsat 8 and Sentinel-2 imagery were processed from image data acquired by NASA's AVIRIS airborne sensor in year 2015, with summer and multi-temporal (spring, summer, fall) data analyzed separately. HyspIRI reflectance was used to generate a suite of hyperspectral metrics that targeted key spectral features related to chemical and structural properties. The Random Forests classifier was applied to the simulated images and overall accuracies (OA) were compared to those from real Landsat 8 images. For each image group, broad land cover (e.g., Needle-leaf Trees, Broad-leaf Trees, Annual agriculture, Herbaceous, Built-up) was classified first, followed by a finer-detail forest alliance classification for pixels mapped as closed-canopy forest. There were 5 needle-leaf tree alliances and 16 broad-leaf tree alliances, including 7 Quercus (oak) alliance types. No forest alliance classification exceeded 50% OA, indicating that there was broad spectral similarity among alliances, most of which were not spectrally pure but rather a mix of tree species. In general, needle-leaf (Pine, Redwood, Douglas Fir) alliances had better class accuracies than broad-leaf alliances (Oaks, Madrone, Bay Laurel, Buckeye, etc). Multi-temporal data classifications all had 5-6% greater OA than with comparable summer data. For simulated data, HyspIRI metrics had 4-5% greater OA than Landsat 8 and Sentinel-2 multispectral imagery and 3-4% greater OA than HyspIRI reflectance. Finally, HyspIRI metrics had 8% greater OA than real Landsat 8 imagery. In conclusion, forest alliance classification was found to be a difficult remote sensing application with moderate resolution (30 m) satellite imagery; however, of the data tested, HyspIRI spectral metrics had the best performance relative to multispectral satellites.

The meaning of empowerment within Italian nursing care settings.

PubMed

Rega, Maria Luisa; Diano, Pasquale; Damiani, Gianfranco; De Vito, Corrado; Galletti, Caterina; Talucci, Carlo

2017-11-01

To examine the current state of empowerment of nurses in Italy. Empowerment is a broad concept that is also relevant to the field of nursing practice. Its comprehension and use are important because empowerment allows nurses to take control of their own practice. A clear understanding of empowerment is necessary for nurses to take advantage of this important tool. Focus groups were conducted. A literature review was performed, and two focus groups were selected between January and February 2014. Sixteen nurses participated in the research. Empowerment is seen as being strongly connected to autonomy and is not associated with power, as the word itself suggests. Italian nurses define empowerment as the creation of conditions that help to establish the possibility for people to develop and express their value and potential. Empowerment is defined as a condition in which the individual nurse takes control of his/her own practice and thereby provides awareness and confidence to a group. Italian nurses need to feel appreciated and supported by their own organisations. If warranted, empowerment would allow them to contribute to enhance care, which is the core of the nursing profession. © 2017 John Wiley & Sons Ltd.

Public health literacy defined.

PubMed

Freedman, Darcy A; Bess, Kimberly D; Tucker, Holly A; Boyd, David L; Tuchman, Arleen M; Wallston, Kenneth A

2009-05-01

Public health literacy is an emerging concept necessary to understand and address the broad array of factors, such as climate change, globalization, and poverty, that influence the public's health. Whereas health literacy has traditionally been operationalized as an individual-level construct, public health literacy takes into account the complex social, ecologic, and systemic forces affecting health and well-being. However, public health literacy has not yet been fully articulated. This paper addresses this gap by outlining a broad, new definition of public health literacy. This definition was developed through an inductive analytic process conducted in 2007 by a multidisciplinary research team, and two expert-panel sessions were convened to assess the consensual validity of the emergent definition. Based on this process, public health literacy is defined as the degree to which individuals and groups can obtain, process, understand, evaluate, and act on information needed to make public health decisions that benefit the community. Three dimensions of public health literacy--conceptual foundations, critical skills, and civic orientation--and related competencies are also proposed. Public health literacy is distinct from individual-level health literacy, and together, the two types of literacy form a more comprehensive model of health literacy. A five-part agenda is offered for future research and action aimed at increasing levels of public health literacy.

Visionmaker NYC: A bottom-up approach to finding shared socioeconomic pathways in New York City

NASA Astrophysics Data System (ADS)

Sanderson, E. W.; Fisher, K.; Giampieri, M.; Barr, J.; Meixler, M.; Allred, S. B.; Bunting-Howarth, K. E.; DuBois, B.; Parris, A. S.

2015-12-01

Visionmaker NYC is a free, public participatory, bottom-up web application to develop and share climate mitigation and adaptation strategies for New York City neighborhoods. The goal is to develop shared socioeconomic pathways by allowing a broad swath of community members - from schoolchildren to architects and developers to the general public - to input their concepts for a desired future. Visions are comprised of climate scenarios, lifestyle choices, and ecosystem arrangements, where ecosystems are broadly defined to include built ecosystems (e.g. apartment buildings, single family homes, etc.), transportation infrastructure (e.g. highways, connector roads, sidewalks), and natural land cover types (e.g. wetlands, forests, estuary.) Metrics of water flows, carbon cycling, biodiversity patterns, and population are estimated for the user's vision, for the same neighborhood today, and for that neighborhood as it existed in the pre-development state, based on the Welikia Project (welikia.org.) Users can keep visions private, share them with self-defined groups of other users, or distribute them publicly. Users can also propose "challenges" - specific desired states of metrics for specific parts of the city - and others can post visions in response. Visionmaker contributes by combining scenario planning, scientific modelling, and social media to create new, wide-open possibilities for discussion, collaboration, and imagination regarding future, shared socioeconomic pathways.

Identifying designatable units for intraspecific conservation prioritization: a hierarchical approach applied to the lake whitefish species complex (Coregonus spp.)

PubMed Central

Mee, Jonathan A; Bernatchez, Louis; Reist, Jim D; Rogers, Sean M; Taylor, Eric B

2015-01-01

The concept of the designatable unit (DU) affords a practical approach to identifying diversity below the species level for conservation prioritization. However, its suitability for defining conservation units in ecologically diverse, geographically widespread and taxonomically challenging species complexes has not been broadly evaluated. The lake whitefish species complex (Coregonus spp.) is geographically widespread in the Northern Hemisphere, and it contains a great deal of variability in ecology and evolutionary legacy within and among populations, as well as a great deal of taxonomic ambiguity. Here, we employ a set of hierarchical criteria to identify DUs within the Canadian distribution of the lake whitefish species complex. We identified 36 DUs based on (i) reproductive isolation, (ii) phylogeographic groupings, (iii) local adaptation and (iv) biogeographic regions. The identification of DUs is required for clear discussion regarding the conservation prioritization of lake whitefish populations. We suggest conservation priorities among lake whitefish DUs based on biological consequences of extinction, risk of extinction and distinctiveness. Our results exemplify the need for extensive genetic and biogeographic analyses for any species with broad geographic distributions and the need for detailed evaluation of evolutionary history and adaptive ecological divergence when defining intraspecific conservation units. PMID:26029257

The California corridor transportation system: A design summary

NASA Technical Reports Server (NTRS)

1990-01-01

A design group was assembled to find and research criteria relevent to the design of a California Corridor Transportation System. The efforts of this group included defining the problem, conducting a market analysis, formulation of a demand model, identification and evaluation of design drivers, and the systematic development of a solution. The problems of the current system were analyzed and used to determine design drivers, which were divided into the broad categories of cost, convenience, feasibility, environment, safety, and social impact. The relative importance of individual problems was addressed, resulting in a hierarchy of design drivers. Where possible, methods of evaluating the relative merit of proposed systems with respect to each driver were developed. Short takeoff vertical landing aircraft concepts are also discussed for supersonic fighters.

Taking Stock of Unrealistic Optimism

PubMed Central

Shepperd, James A.; Klein, William M. P.; Waters, Erika A.; Weinstein, Neil D.

2015-01-01

Researchers have used terms such as unrealistic optimism and optimistic bias to refer to concepts that are similar but not synonymous. Drawing from three decades of research, we critically discuss how researchers define unrealistic optimism and we identify four types that reflect different measurement approaches: unrealistic absolute optimism at the individual and group level and unrealistic comparative optimism at the individual and group level. In addition, we discuss methodological criticisms leveled against research on unrealistic optimism and note that the criticisms are primarily relevant to only one type—the group form of unrealistic comparative optimism. We further clarify how the criticisms are not nearly as problematic even for unrealistic comparative optimism as they might seem. Finally, we note boundary conditions on the different types of unrealistic optimism and reflect on five broad questions that deserve further attention. PMID:26045714

Patterns of Limnohabitans Microdiversity across a Large Set of Freshwater Habitats as Revealed by Reverse Line Blot Hybridization

PubMed Central

Jezbera, Jan; Jezberová, Jitka; Kasalický, Vojtěch; Šimek, Karel; Hahn, Martin W.

2013-01-01

Among abundant freshwater Betaproteobacteria, only few groups are considered to be of central ecological importance. One of them is the well-studied genus Limnohabitans and mainly its R-BT subcluster, investigated previously mainly by fluorescence in situ hybridization methods. We designed, based on sequences from a large Limnohabitans culture collection, 18 RLBH (Reverse Line Blot Hybridization) probes specific for different groups within the genus Limnohabitans by targeting diagnostic sequences on their 16 S–23 S rRNA ITS regions. The developed probes covered in sum 92% of the available isolates. This set of probes was applied to environmental DNA originating from 161 different European standing freshwater habitats to reveal the microdiversity (intra-genus) patterns of the Limnohabitans genus along a pH gradient. Investigated habitats differed in various physicochemical parameters, and represented a very broad range of standing freshwater habitats. The Limnohabitans microdiversity, assessed as number of RLBH-defined groups detected, increased significantly along the gradient of rising pH of habitats. 14 out of 18 probes returned detection signals that allowed predictions on the distribution of distinct Limnohabitans groups. Most probe-defined Limnohabitans groups showed preferences for alkaline habitats, one for acidic, and some seemed to lack preferences. Complete niche-separation was indicated for some of the probe-targeted groups. Moreover, bimodal distributions observed for some groups of Limnohabitans, suggested further niche separation between genotypes within the same probe-defined group. Statistical analyses suggested that different environmental parameters such as pH, conductivity, oxygen and altitude influenced the distribution of distinct groups. The results of our study do not support the hypothesis that the wide ecological distribution of Limnohabitans bacteria in standing freshwater habitats results from generalist adaptations of these bacteria. Instead, our observations suggest that the genus Limnohabitans, as well as its R-BT subgroup, represent ecologically heterogeneous taxa, which underwent pronounced ecological diversification. PMID:23554898

Defining Hardwood Veneer Log Quality Attributes

Treesearch

Jan Wiedenbeck; Michael Wiemann; Delton Alderman; John Baumgras; William Luppold

2004-01-01

This publication provides a broad spectrum of information on the hardwood veneer industry in North America. Veneer manufacturers and their customers impose guidelines in specifying wood quality attributes that are very discriminating but poorly defined (e.g., exceptional color, texture, and/or figure characteristics). To better understand and begin to define the most...

20 CFR 725.493 - Employment relationship defined.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Employment relationship defined. 725.493... relationship defined. (a)(1) In determining the identity of a responsible operator under this part, the terms “employ” and “employment” shall be construed as broadly as possible, and shall include any relationship...

20 CFR 725.493 - Employment relationship defined.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Employment relationship defined. 725.493... relationship defined. (a)(1) In determining the identity of a responsible operator under this part, the terms “employ” and “employment” shall be construed as broadly as possible, and shall include any relationship...

A Broadly Flavivirus Cross-Neutralizing Monoclonal Antibody that Recognizes a Novel Epitope within the Fusion Loop of E Protein

PubMed Central

Jiang, Tao; Wang, Hua-Jing; Yang, Hai-ou; Tan, Weng-Long; Liu, Ran; Yu, Man; Ge, Bao-Xue; Zhu, Qing-Yu; Qin, E-De; Guo, Ya-Jun; Qin, Cheng-Feng

2011-01-01

Flaviviruses are a group of human pathogenic, enveloped RNA viruses that includes dengue (DENV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses. Cross-reactive antibodies against Flavivirus have been described, but most of them are generally weakly neutralizing. In this study, a novel monoclonal antibody, designated mAb 2A10G6, was determined to have broad cross-reactivity with DENV 1–4, YFV, WNV, JEV, and TBEV. Phage-display biopanning and structure modeling mapped 2A10G6 to a new epitope within the highly conserved flavivirus fusion loop peptide, the 98DRXW101 motif. Moreover, in vitro and in vivo experiments demonstrated that 2A10G6 potently neutralizes DENV 1–4, YFV, and WNV and confers protection from lethal challenge with DENV 1–4 and WNV in murine model. Furthermore, functional studies revealed that 2A10G6 blocks infection at a step after viral attachment. These results define a novel broadly flavivirus cross-reactive mAb with highly neutralizing activity that can be further developed as a therapeutic agent against severe flavivirus infections in humans. PMID:21264311

Broad supernatural punishment but not moralizing high gods precede the evolution of political complexity in Austronesia

PubMed Central

Watts, Joseph; Greenhill, Simon J.; Atkinson, Quentin D.; Currie, Thomas E.; Bulbulia, Joseph; Gray, Russell D.

2015-01-01

Supernatural belief presents an explanatory challenge to evolutionary theorists—it is both costly and prevalent. One influential functional explanation claims that the imagined threat of supernatural punishment can suppress selfishness and enhance cooperation. Specifically, morally concerned supreme deities or ‘moralizing high gods' have been argued to reduce free-riding in large social groups, enabling believers to build the kind of complex societies that define modern humanity. Previous cross-cultural studies claiming to support the MHG hypothesis rely on correlational analyses only and do not correct for the statistical non-independence of sampled cultures. Here we use a Bayesian phylogenetic approach with a sample of 96 Austronesian cultures to test the MHG hypothesis as well as an alternative supernatural punishment hypothesis that allows punishment by a broad range of moralizing agents. We find evidence that broad supernatural punishment drives political complexity, whereas MHGs follow political complexity. We suggest that the concept of MHGs diffused as part of a suite of traits arising from cultural exchange between complex societies. Our results show the power of phylogenetic methods to address long-standing debates about the origins and functions of religion in human society. PMID:25740888

Patient similarity for precision medicine: a systematic review.

PubMed

Parimbelli, E; Marini, S; Sacchi, L; Bellazzi, R

2018-06-01

Evidence-based medicine is the most prevalent paradigm adopted by physicians. Clinical practice guidelines typically define a set of recommendations together with eligibility criteria that restrict their applicability to a specific group of patients. The ever-growing size and availability of health-related data is currently challenging the broad definitions of guideline-defined patient groups. Precision medicine leverages on genetic, phenotypic, or psychosocial characteristics to provide precise identification of patient subsets for treatment targeting. Defining a patient similarity measure is thus an essential step to allow stratification of patients into clinically-meaningful subgroups. The present review investigates the use of patient similarity as a tool to enable precision medicine. 279 articles were analyzed along four dimensions: data types considered, clinical domains of application, data analysis methods, and translational stage of findings. Cancer-related research employing molecular profiling and standard data analysis techniques such as clustering constitute the majority of the retrieved studies. Chronic and psychiatric diseases follow as the second most represented clinical domains. Interestingly, almost one quarter of the studies analyzed presented a novel methodology, with the most advanced employing data integration strategies and being portable to different clinical domains. Integration of such techniques into decision support systems constitutes and interesting trend for future research. Copyright © 2018. Published by Elsevier Inc.

[Sexual harassment in medical organizations].

PubMed

Rabinerson, David; Maman, Maor; Glezerman, Marek

2008-01-01

Sexual harassment is quite prevalent in medical organizations. The two most affected groups are medical students and nurses. In its broad perspective, sexual harassment is defined as any type of offensive behavior with sexual connotation aimed at any individual or minority. In Israel, sexual harassment is regarded as such only in the literal sense, although recently, courts tend to adopt a more comprehensive approach in their ruling. Final legislation of the law against sexual harassment, which includes employer liability for the actions of its workers, caused increased awareness of the phenomenon of sexual harassment and may serve in reducing its prevalence in the medical environment.

Chronic obstructive pulmonary disease: knowing what we mean, meaning what we say.

PubMed

Joshi, J M

2008-01-01

Chronic obstructive pulmonary disease (COPD) is defined in several different ways using different criteria based on symptoms, physiological impairment and pathological abnormalities. While some use COPD to mean smoking related chronic airway disease, others include all disorders causing chronic airway obstruction. When COPD is used as a broad descriptive term, specific disorders that cause chronic airway obstruction remain under-diagnosed and the prevalence estimates vary considerably. The lack of agreement over the precise terminology and classification of COPD has resulted in widespread confusion. Terminology includes definition, diagnostic criteria, and a system for staging severity. Recently, COPD is defined more clearly and diagnosed using precise criteria that include tobacco smoking greater than 10 pack years, symptoms and airway obstruction on spirometry. A multi-dimensional severity grading system, the BODE (body mass index, obstruction, dyspnoea, and exercise tolerance) index has been designed to assess the respiratory and systemic expressions of COPD. This review proposes that the broad group of chronic disorders of the airways (with or without airway obstruction) be called chronic airway disease (CAD). The term COPD should be used exclusively for tobacco smoking related chronic airway disease. Chronic airway obstruction or obstructive lung disease may be used to define those conditions with airways obstruction caused by factors other than tobacco smoking. The aetiology may be appended to the label, for example, chronic airway obstruction/obstructive lung disease associated with bronchiectasis, chronic airway obstruction/obstructive lung disease associated with obliterative bronchiolitis or chronic airway obstruction/obstructive lung disease due to biomass fuel/occupational exposure.

An evaluation of cause-of-death trends from recent decades based on registered deaths in Turkey.

PubMed

Özdemir, R; Dinç Horasan, G; Rao, C; Sözmen, M K; Ünal, B

2017-10-01

Although cause-of-death analyses are very important to define public health policy priorities and to evaluate health programs, there is very limited knowledge about mortality profiles and trends in Turkey. The aim of this study was to measure the trends in mortality within three broad cause-of-death groups and their distribution by age groups and gender and to describe the changes of leading causes of death between 1980 and 2013 in Turkey. Descriptive study. In the study, data on the number of deaths by year, gender, age and cause was obtained from the Turkish Statistical Institute. The causes of death were classified as group I: communicable, maternal, perinatal, and nutritional conditions; group II: non-communicable diseases (NCDs); and group III: injuries. Unknown or ill-defined causes of death were distributed within group I and group II. The percentage distribution of the cause-of-death groups by gender and age groups between 1980 and 2013 was identified. Age-standardized mortality rates (ASMRs) per 100,000 of broad causes-of-death groups were calculated using European Standard Population 1976 between 1980 and 2008. Changes in mortality rates per hundred were calculated using the formula ([the rate of last year of the period-the rate of the first year of the period]/the rate of the first year of the period). Gender and age-specific data were analyzed using the Joinpoint software to examine trends and significant changes in trends of mortality rates. Crude death rates for group I, group II, and group III were 157.3, 147.2, and 21.4 per 100,000 in 1980 and 35.3, 377.5, and 15.8 in 2008 for males; 161.8, 120.2, and 5.8 in 1980 and 38.6, 318.4, and 6.4 in 2008 for females, respectively. ASMRs for group I, group II, and group III were 146.3, 394.3, and 29.3 per 100,000 in 1980 and 49.7, 723.6, and 18.8 in 2008 for males; 138.0, 291.5, and 7.6 per 100,000 in 1980 and 47.7, 478.8, and 7.2 in 2008 for females, respectively. The mortality rates of group I for almost all age groups particularly below 5 years of age decreased significantly. This study indicates that Turkey is at an advanced stage in the epidemiological transition, with the majority of the causes of death from NCDs. Considering the regional differences, it is necessary to carry out studies on the specific details of epidemiological transition and the social determinants of deaths in Turkey. Copyright © 2017 The Royal Society for Public Health. All rights reserved.

SAGES's advanced GI/MIS fellowship curriculum pilot project.

PubMed

Weis, Joshua J; Goldblatt, Matthew; Pryor, Aurora; Dunkin, Brian J; Brunt, L Michael; Jones, Daniel B; Scott, Daniel J

2018-06-01

The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015. These data were used to propose new criteria designed to provide adequate exposure to core content. The working group also proposed using video assessment of an MIS case to provide objective assessment of competency. Case log data were available for 326 fellows with a total of 85,154 cases logged (median 227 per fellow). The working group proposed new criteria starting with minimum case volumes for five defined categories including foregut (20), bariatrics (25), inguinal hernia (10), ventral hernia (10), and solid organ/colon/thoracic (10). Fellows are expected to perform an additional 75 complex MIS cases of any category for a total of 150 required cases overall. The proposal also included a minimum volume of flexible endoscopy (50) and submission of an MIS foregut case for video assessment. The new criteria more clearly defined which surgeon roles count for major credit within individual categories. Fourteen fellowships volunteered to pilot these new criteria for the 2017-2018 academic year. The new SAGES Advanced GI/MIS fellowship has been crafted to better define the core content that should be contained in these fellowships, while still allowing sufficient heterogeneity so that individual learners can tailor their training to specific areas of interest. The criteria also introduce innovative, evidence-based methods for assessing competency. Pending the results of the pilot program, SAGES will consider broad implementation of the new fellowship criteria.

Social-Cognition and the Broad Autism Phenotype: Identifying Genetically Meaningful Phenotypes

ERIC Educational Resources Information Center

Losh, Molly; Piven, Joseph

2007-01-01

Background: Strong evidence from twin and family studies suggests that the genetic liability to autism may be expressed through personality and language characteristics qualitatively similar, but more subtly expressed than those defining the full syndrome. This study examined behavioral features of this "broad autism phenotype" (BAP) in relation…

Nature and Content of Contemporary Economics.

ERIC Educational Resources Information Center

Brimmer, Andrew F.

Economics does not have sharply delineated boundaries, but the domain has been defined broadly, and differently, from time-to-time. Currently, the contents of economics can be divided into the following broad areas: macroeconomics, microeconomics, and development economics. Most economists specialize in one or more of the more narrowly defined…

The Broad Autism Phenotype Questionnaire

ERIC Educational Resources Information Center

Hurley, Robert S. E.; Losh, Molly; Parlier, Morgan; Reznick, J. Steven; Piven, Joseph

2007-01-01

The broad autism phenotype (BAP) is a set of personality and language characteristics that reflect the phenotypic expression of the genetic liability to autism, in non-autistic relatives of autistic individuals. These characteristics are milder but qualitatively similar to the defining features of autism. A new instrument designed to measure the…

Towards a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders

PubMed Central

Mattson, Sarah N.; Roesch, Scott C.; Fagerlund, Åse; Autti-Rämö, Ilona; Jones, Kenneth Lyons; May, Philip A.; Adnams, Colleen M.; Konovalova, Valentina; Riley, Edward P.

2010-01-01

Background A primary goal of recent research is the development of neurobehavioral profiles that specifically define fetal alcohol spectrum disorders (FASD), which may assist differential diagnosis or improve treatment. In the current study we define a preliminary profile using neuropsychological data from a multisite study. Methods Data were collected using a broad neurobehavioral protocol from two sites of a multisite study of FASD. Subjects were children with heavy prenatal alcohol exposure and unexposed controls. The alcohol-exposed group included children with and with out fetal alcohol syndrome (FAS). From 547 neuropsychological, 22 variables were selected for analysis based on their ability to distinguish children with heavy prenatal alcohol exposure from nonexposed controls. These data were analyzed using latent profile analysis (LPA). Results The results indicated that a 2-class model best fit the data. The resulting profile was successful at distinguishing subjects with FAS from nonexposed controls without FAS with 92% overall accuracy; 87.8% of FAS cases and 95.7% of controls were correctly classified. The same analysis was repeated with children with heavy prenatal alcohol exposure but without FAS and non-exposed controls with similar results. The overall accuracy was 84.7%; 68.4% of alcohol-exposed cases and 95% of controls were correctly classified. In both analyses, the profile based on neuropsychological variables was more successful at distinguishing the groups than was IQ alone. Conclusions We used data from two sites of a multisite study and a broad neuropsychological test battery to determine a profile that could be used to accurately identify children affected by prenatal alcohol exposure. Results indicated that measures of executive function and spatial processing are especially sensitive to prenatal alcohol exposure. PMID:20569243

Elastic fibres are broadly distributed in tendon and highly localized around tenocytes

PubMed Central

Grant, Tyler M; Thompson, Mark S; Urban, Jill; Yu, Jing

2013-01-01

Elastic fibres have the unique ability to withstand large deformations and are found in numerous tissues, but their organization and structure have not been well defined in tendon. The objective of this study was to characterize the organization of elastic fibres in tendon to understand their function. Immunohistochemistry was used to visualize elastic fibres in bovine flexor tendon with fibrillin-1, fibrillin-2 and elastin antibodies. Elastic fibres were broadly distributed throughout tendon, and highly localized longitudinally around groups of cells and transversely between collagen fascicles. The close interaction of elastic fibres and cells suggests that elastic fibres are part of the pericellular matrix and therefore affect the mechanical environment of tenocytes. Fibres present between fascicles are likely part of the endotenon sheath, which enhances sliding between adjacent collagen bundles. These results demonstrate that elastic fibres are highly localized in tendon and may play an important role in cellular function and contribute to the tissue mechanics of the endotenon sheath. PMID:23587025

Tectono-stratigraphic evolution of the Comondú Group from Bahía de La Paz to Loreto, Baja California Sur, Mexico

NASA Astrophysics Data System (ADS)

Drake, William R.; Umhoefer, Paul J.; Griffiths, Alexis; Vlad, Ann; Peters, Lisa; McIntosh, William

2017-11-01

The late Oligocene to mid-Miocene volcanic and volcaniclastic rocks of the Comondú Group are well exposed along the Main Rift Escarpment of Baja California Sur from the Bahía de La Paz region to Bahía Concepción. New mapping and stratigraphic analysis of the Comondú Group from Bahía de La Paz to Loreto reveal facies trends and correlations that form the foundation for a continuous stratigraphic framework for the Comondú Group along a 300 km-long transect on the eastern coast of the Baja California peninsula. Broad but distinct lithostratigraphic trends, alluvial fan facies, and volcanic and volcaniclastic facies record an overall coarsening-upwards package that includes ignimbrite deposits within increasingly proximal alluvial fan deposits, both derived from the east. Geochronology of the unit, including 32 isotope ages and 12 previously unpublished 40Ar/39Ar ages, provide the timing of four main increasingly proximal depositional events. Non-marine sandstone, defining the base of the Comondú Group, was first deposited between 26 Ma and 24 Ma. Emplacement of rhyolitic ignimbrites initiated between 24 Ma and 23 Ma and marked a westward expansion of volcanic activity affiliated with the Sierra Madre Occidental ignimbrite sequences in southern Sinaloa, western Durango, and northern Nayarit. A change in volcanism occurred at 19 Ma to 18 Ma with more ignimbrites, increased intermediate compositions, and the appearance of local vents and proximal volcanic facies. A final localized change of volcanism occurred from 14 to 12 Ma in the Loreto area with an increase of proximal alluvial fan deposits and local volcanoes in the Upper Comondú Group. The bulk of the Upper Comondú Group is absent south of the Loreto area and has either been removed by erosion as a source for the Magdalena Fan in the Pacific Ocean, or was focused primarily in the Loreto area and northward. We use a pre-rift tectonic reconstruction of the Gulf of California to align broad stratigraphic trends along the peninsula, the Gulf conjugate margins, and within the Gulf. The Cascadia arc of Oregon and northern California may be a modern analog for the Comondú Group with a linear volcanic arc formed above shrinking subducting microplates, and a broad backarc region of moderate extension and scattered volcanism.

Perceived reasons for loss of housing and continued homelessness among homeless persons with mental illness.

PubMed

Mojtabai, Ramin

2005-02-01

The objective of this study was to examine the reasons for the most recent loss of housing and for continued homelessness as perceived by homeless persons with mental illness. A total of 2,974 currently homeless participants in the 1996 National Survey of Homeless Assistance Providers and Clients (NSHAPC) were asked about the reasons for their most recent loss of housing and continued homelessness. The responses of participants who had mental illness, defined both broadly and narrowly, were compared with responses of those who were not mentally ill. The broad definition of mental illness was based on a set of criteria proposed by NSHAPC investigators. The narrow definition included past psychiatric hospitalization in addition to the NSHAPC criteria. A total of 1,620 participants (56 percent) met the broad definition of mental illness, and 639 (22 percent) met the narrow definition; 1,345 participants (44 percent) did not meet any of these criteria and were categorized as not having a mental illness. Few differences in reasons for the most recent loss of housing were noted between the participants with and without mental illness. Both groups attributed their continued homelessness mostly to insufficient income, unemployment, and lack of suitable housing. Homeless persons with mental illness mostly report the same reasons for loss of housing and continued homelessness as those who do not have a mental illness. This finding supports the view that structural solutions, such as wider availability of low-cost housing and income support, would reduce the risk of homelessness among persons with mental illness, as among other vulnerable social groups.

China's Education Policy-Making: A Policy Network Perspective

ERIC Educational Resources Information Center

Han, Shuangmiao; Ye, Fugui

2017-01-01

Policy network approach has become a broadly accepted and frequently adopted practice in modern state governance, especially in the public sector. The study utilises a broadly defined policy network conceptual frame and categories of reference to trace the evolution of education policy-making in China. The study uses "The Outline of China's…

Genetic Advances in Autism: Heterogeneity and Convergence on Shared Pathways

PubMed Central

Bill, Brent R.; Geschwind, Daniel H.

2009-01-01

The autism spectrum disorders (ASD) are a heterogeneous set of developmental disorders characterized at their core by deficits in social interaction and communication. Current psychiatric nosology groups this broad set of disorders with strong genetic liability and multiple etiologies into the same diagnostic category. This heterogeneity has challenged genetic analyses. But shared patient resources, genomic technologies, more refined phenotypes, and novel computational approaches have begun to yield dividends in defining the genetic mechanisms at work. Over the last five years, a large number of autism susceptibility loci have emerged, redefining our notion of autism’s etiologies, and reframing how we think about ASD. PMID:19477629

Towards a new definition of return-to-work outcomes in common mental disorders from a multi-stakeholder perspective.

PubMed

Hees, Hiske L; Nieuwenhuijsen, Karen; Koeter, Maarten W J; Bültmann, Ute; Schene, Aart H

2012-01-01

To examine the perspectives of key stakeholders involved in the return-to-work (RTW) process regarding the definition of successful RTW outcome after sickness absence related to common mental disorders (CMD's). A mixed-method design was used: First, we used qualitative methods (focus groups, interviews) to identify a broad range of criteria important for the definition of successful RTW (N = 57). Criteria were grouped into content-related clusters. Second, we used a quantitative approach (online questionnaire) to identify, among a larger stakeholder sample (N = 178), the clusters and criteria most important for successful RTW. A total of 11 clusters, consisting of 52 unique criteria, were identified. In defining successful RTW, supervisors and occupational physicians regarded "Sustainability" and "At-work functioning" most important, while employees regarded "Sustainability," "Job satisfaction," "Work-home balance," and "Mental Functioning" most important. Despite agreement on the importance of certain criteria, considerable differences among stakeholders were observed. Key stakeholders vary in the aspects and criteria they regard as important when defining successful RTW after CMD-related sickness absence. Current definitions of RTW outcomes used in scientific research may not accurately reflect these key stakeholder perspectives. Future studies should be more aware of the perspective from which they aim to evaluate the effectiveness of a RTW intervention, and define their RTW outcomes accordingly.

Broad supernatural punishment but not moralizing high gods precede the evolution of political complexity in Austronesia.

PubMed

Watts, Joseph; Greenhill, Simon J; Atkinson, Quentin D; Currie, Thomas E; Bulbulia, Joseph; Gray, Russell D

2015-04-07

Supernatural belief presents an explanatory challenge to evolutionary theorists-it is both costly and prevalent. One influential functional explanation claims that the imagined threat of supernatural punishment can suppress selfishness and enhance cooperation. Specifically, morally concerned supreme deities or 'moralizing high gods' have been argued to reduce free-riding in large social groups, enabling believers to build the kind of complex societies that define modern humanity. Previous cross-cultural studies claiming to support the MHG hypothesis rely on correlational analyses only and do not correct for the statistical non-independence of sampled cultures. Here we use a Bayesian phylogenetic approach with a sample of 96 Austronesian cultures to test the MHG hypothesis as well as an alternative supernatural punishment hypothesis that allows punishment by a broad range of moralizing agents. We find evidence that broad supernatural punishment drives political complexity, whereas MHGs follow political complexity. We suggest that the concept of MHGs diffused as part of a suite of traits arising from cultural exchange between complex societies. Our results show the power of phylogenetic methods to address long-standing debates about the origins and functions of religion in human society. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Assessing the evolving definition of underrepresented minority and its application in academic medicine.

PubMed

Page, Kathleen Raquel; Castillo-Page, Laura; Poll-Hunter, Norma; Garrison, Gwen; Wright, Scott M

2013-01-01

To assess how U.S. academic health centers (AHCs) define the term underrepresented minority (URM) and apply it to their diversity programs, following the 2003 revision of the Association of American Medical Colleges' (AAMC's) definition of URM. In 2010, the authors developed and deployed a cross-sectional survey of diversity leaders at 106 AHCs. The survey included questions about the diversity leader and institution's diversity program; institution's URM definition; application of that definition; and the diversity leader's perceptions of the representation and institutional contribution of various ethnic/racial groups. The authors used descriptive statistics to analyze the results. Of the 106 diversity leaders invited, 89 (84.0%) responded and 78 (73.6%) provided a working definition of URM. Most programs (40/78; 51%) used the 2003 AAMC definition of URM, which includes racial/ethnic groups that are underrepresented in medicine relative to local and national demographics. Only 14.1% (11/78) used the pre-2003 AAMC definition, which included only African Americans, Mexican Americans, Native Americans, and mainland Puerto Ricans. Approximately one-third (23/78; 29.5%) also considered other diversity factors, such as socioeconomic status, sexual orientation, and disability, in defining URM. Fifty-eight respondents (74.4%) confirmed that their diversity programs targeted specific groups. The definition of URM used by diversity programs at U.S. AHCs varied widely. Although some classified URMs by racial/ethnic categories, the majority defined URM more broadly to encompass other demographic and personal characteristics. This shift should prepare academic medicine to eliminate health disparities and meet the health needs of an increasingly diverse population.

Groups and the Entropy Floor: XMM-Newton Observations of Two Groups

NASA Technical Reports Server (NTRS)

Mushotzky, R. F.; Figueroa-Feliciano, E.; Loewenstein, M.; Snowden, S. L.

2002-01-01

Using XMM-Newton spatially resolved X-ray imaging spectroscopy we obtain the temperature, density, entropy, gas mass, and total mass profiles for two groups of galaxies out to approximately 0.3 R(sub vir)(R(sub vir), the virial radius). Our density profiles agree well with those derived previously, and the temperature data are broadly consistent with previous results but are considerably more precise. Both of these groups are at the mass scale of 2x10(exp 13) M(solar mass), but have rather different properties. Both have considerably lower gas mass fractions at r < 0.3 R(sub vir), than the rich clusters. NGC2563, one of the least luminous groups for its X-ray temperature, has a very low gas mass fraction of approximately 0.004 inside 0.1 R(sub vir), which increases with radius. NGC4325, one of the most luminous groups at the same average temperature, has a higher gas mass fraction of 0.02. The entropy profiles and the absolute values of the entropy as a function of virial radius also differ, with NGC4325 having a value of approximately 100 keV cm(exp -2) and NGC2563 a value of approximately 300 keV cm(exp -2) at r approximately 0.1 R(sub vir). For both groups the profiles rise monotonically with radius and there is no sign of an entropy 'floor'. These results are inconsistent with pre-heating scenarios that have been developed to explain a possible entropy floor in groups, but are broadly consistent with models of structure formation that include the effects of heating and/or the cooling of the gas. The total entropy in these systems provides a strong constraint on all models of galaxy and group formation, and on the poorly defined feedback process that controls the transformation of gas into stars and thus the formation of structure in the universe.

Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus

PubMed Central

Smeesters, Pierre R.; Frost, Hannah R. C.; Steer, Andrew C.

2015-01-01

Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection. In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates. PMID:26101780

Forging Vertical Linkages in the Public Sphere: School-Church Engagement for Social Justice

ERIC Educational Resources Information Center

Miller, Peter M.; Engel, Max T.

2011-01-01

Within the broad discussion of social justice in education, multiple conceptualizations of the term have been posited. Although there is no uniform notion of social justice, most would concur that, "Social justice, broadly defined, refers to a condition whereby all people are afforded fair opportunities to enjoy the benefits of society" (Miller,…

Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study).

PubMed

van der Does, Yuri; Limper, Maarten; Jie, Kim E; Schuit, Stephanie C E; Jansen, Henry; Pernot, Niki; van Rosmalen, Joost; Poley, Marten J; Ramakers, Christian; Patka, Peter; van Gorp, Eric C M; Rood, Pleunie P M

2018-06-02

Overuse of broad-spectrum antibiotics in emergency departments(EDs) results in antibiotic resistance. We determined if procalcitonin(PCT)-guided therapy can be used to reduce antibiotic regimens in EDs by investigating efficacy, safety and accuracy. This was a noninferiority multicenter randomized clinical trial, performed in two Dutch hospitals. Adult patients with fever ≥38.2°C(100.8°F) in triage were randomized between standard diagnostic workup(control group) and PCT-guided therapy, defined as standard workup with addition of one single PCT measurement. Treatment algorithm encouraged withholding antibiotic regimens with PCT<0.5μg/L, and starting antibiotic regimens PCT≥0.5μg/L. Exclusion criteria were immunocompromised conditions, pregnancy, moribund patients, patients <72h after surgery or requiring primary surgical intervention. Primary outcomes were efficacy, defined as number of prescribed antibiotic regimens; safety, defined as combined-safety-endpoint(CSE) consisting of 30-days mortality, intensive-care unit admission, ED-return-visit within 2 weeks; accuracy, defined as sensitivity, apecificity and area-under-the-curve(AUC) of PCT for bacterial infections. Noninferiority margin for safety outcome was 7.5%. Between August 2014 and January 2017, 551 patients were included. In the PCT-guided group(n=275) 200(73%)patients were prescribed antibiotic regimens, in the control group(n=276) 212(77%)(p=0.28). There was no significant difference in CSE between the PCT-guided group, 29(11%), and control group, 46(16%)(p=0.16), with a noninferiority margin of 0.46%(n=526). AUC for confirmed bacterial infections for PCT was 0.681(95%CI0.633-0.730), for CRP 0.619(95%CI 0.569-0.669).: CONCLUSIONS.: PCT-guided therapy was noninferior in terms of safety, but did not reduce prescription of antibiotic regimens in an ED population with fever. In this heterogeneous population, the accuracy of PCT in diagnosing bacterial infections was poor. TRIAL REGISTRATION IN NETHERLANDS TRIAL REGISTER: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4949. Copyright © 2018. Published by Elsevier Ltd.

Network Aggregation in Transportation Planning : Volume II : A Fixed Point Method for Treating Traffic Equilibria

DOT National Transportation Integrated Search

1978-04-01

Volume 2 defines a new algorithm for the network equilibrium model that works in the space of path flows and is based on the theory of fixed point method. The goals of the study were broadly defined as the identification of aggregation practices and ...

A Question of Evidence

ERIC Educational Resources Information Center

Todd, Ross J.

2008-01-01

Broadly defined, evidence-based practice (EBP) is fundamentally about professional practice being informed and guided by best available evidence of what works. The EBP movement had its origins in the early 1990s in the United Kingdom in medicine and health care services. Sackett et al. defined evidence-based medicine as the "conscientious,…

Size of nesting female Broad-snouted Caimans (Caiman latirostris Daudin 1802).

PubMed

Leiva, P M L; Simoncini, M S; Portelinha, T C G; Larriera, A; Piña, C I

2018-03-12

The southern distribution of the Broad-snouted Caiman (Caiman latirostris Daudin 1802) in Argentina occurs in Santa Fe Province, where its population has been under management by "Proyecto Yacaré" since 1990. From 1997 to 2016, we captured 77 nesting female Broad-snouted Caimans in Santa Fe Province. Our results suggest that previously defined size classes for Broad-snouted Caiman do not adequately describe the reproductively mature female segment of the population. Here we propose to change size ranges for general size classes for Broad-snouted Caiman. In addition, we have observed that reintroduced reproductive females by Proyecto Yacaré represent about 32% of captured females. These results indicate that reintroduced females by the management program are surviving and reproducing in the wild at least up to 20 years.

Fluid physics, thermodynamics, and heat transfer experiments in space

NASA Technical Reports Server (NTRS)

Dodge, F. T.; Abramson, H. N.; Angrist, S. W.; Catton, I.; Churchill, S. W.; Mannheimer, R. J.; Otrach, S.; Schwartz, S. H.; Sengers, J. V.

1975-01-01

An overstudy committee was formed to study and recommend fundamental experiments in fluid physics, thermodynamics, and heat transfer for experimentation in orbit, using the space shuttle system and a space laboratory. The space environment, particularly the low-gravity condition, is an indispensable requirement for all the recommended experiments. The experiments fell broadly into five groups: critical-point thermophysical phenomena, fluid surface dynamics and capillarity, convection at reduced gravity, non-heated multiphase mixtures, and multiphase heat transfer. The Committee attempted to assess the effects of g-jitter and other perturbations of the gravitational field on the conduct of the experiments. A series of ground-based experiments are recommended to define some of the phenomena and to develop reliable instrumentation.

Space system production cost benefits from contemporary philosophies in management and manufacturing

NASA Technical Reports Server (NTRS)

Rosmait, Russell L.

1991-01-01

The cost of manufacturing space system hardware has always been expensive. The Engineering Cost Group of the Program Planning office at Marshall is attempting to account for cost savings that result from new technologies in manufacturing and management. The objective is to identify and define contemporary philosophies in manufacturing and management. The seven broad categories that make up the areas where technological advances can assist in reducing space system costs are illustrated. Included within these broad categories is a list of the processes or techniques that specifically provide the cost savings within todays design, test, production and operations environments. The processes and techniques listed achieve savings in the following manner: increased productivity; reduced down time; reduced scrap; reduced rework; reduced man hours; and reduced material costs. In addition, it should be noted that cost savings from production and processing improvements effect 20 to 40 pct. of production costs whereas savings from management improvements effects 60 to 80 of production cost. This is important because most efforts in reducing costs are spent trying to reduce cost in the production.

Stakeholder participation in comparative effectiveness research: defining a framework for effective engagement

PubMed Central

Deverka, Patricia A; Lavallee, Danielle C; Desai, Priyanka J; Esmail, Laura C; Ramsey, Scott D; Veenstra, David L; Tunis, Sean R

2012-01-01

Aims Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims to define stakeholder engagement and present a conceptual model for involving stakeholders in CER. Materials & methods The definitions and model were developed from a literature search, expert input and experience with the Center for Comparative Effectiveness Research in Cancer Genomics, a proof-of-concept platform for stakeholder involvement in priority setting and CER study design. Results Definitions for stakeholder and stakeholder engagement reflect the target constituencies and their role in CER. The ‘analytic-deliberative’ conceptual model for stakeholder engagement illustrates the inputs, methods and outputs relevant to CER. The model differentiates methods at each stage of the project; depicts the relationship between components; and identifies outcome measures for evaluation of the process. Conclusion While the definitions and model require testing before being broadly adopted, they are an important foundational step and will be useful for investigators, funders and stakeholder groups interested in contributing to CER. PMID:22707880

Stakeholder participation in comparative effectiveness research: defining a framework for effective engagement.

PubMed

Deverka, Patricia A; Lavallee, Danielle C; Desai, Priyanka J; Esmail, Laura C; Ramsey, Scott D; Veenstra, David L; Tunis, Sean R

2012-03-01

AIMS: Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims to define stakeholder engagement and present a conceptual model for involving stakeholders in CER. MATERIALS #ENTITYSTARTX00026; METHODS: The definitions and model were developed from a literature search, expert input and experience with the Center for Comparative Effectiveness Research in Cancer Genomics, a proof-of-concept platform for stakeholder involvement in priority setting and CER study design. RESULTS: Definitions for stakeholder and stakeholder engagement reflect the target constituencies and their role in CER. The 'analytic-deliberative' conceptual model for stakeholder engagement illustrates the inputs, methods and outputs relevant to CER. The model differentiates methods at each stage of the project; depicts the relationship between components; and identifies outcome measures for evaluation of the process. CONCLUSION: While the definitions and model require testing before being broadly adopted, they are an important foundational step and will be useful for investigators, funders and stakeholder groups interested in contributing to CER.

How do you define body image? Exploring conceptual gaps in understandings of body image at an exercise facility.

PubMed

Bailey, K Alysse; Gammage, Kimberley L; van Ingen, Cathy

2017-12-01

The definition of body image has evolved within research; however, less is known about the layperson's understanding of the construct. This study explored how members and student trainees of an exercise facility (designed for older adults, people with physical disability, and those with cardiac complications) defined body image. Nineteen participants completed a one-on-one interview, and seven of those participants took part in six additional focus group meetings. The following main themes were found: stereotypical assumptions about body image (e.g., it is solely a person's weight or merely a woman's issue), body image continua for positive and negative body image, degree of complexity of body image dimensions, broad considerations of body image (e.g., it is self-esteem), and limited knowledge about body image. These findings suggest a need for knowledge translation between researchers and the general public which informs future body image program design. Copyright © 2017 Elsevier Ltd. All rights reserved.

Towards a New Definition of Return-to-Work Outcomes in Common Mental Disorders from a Multi-Stakeholder Perspective

PubMed Central

Hees, Hiske L.; Nieuwenhuijsen, Karen; Koeter, Maarten W. J.; Bültmann, Ute; Schene, Aart H.

2012-01-01

Objectives To examine the perspectives of key stakeholders involved in the return-to-work (RTW) process regarding the definition of successful RTW outcome after sickness absence related to common mental disorders (CMD’s). Methods A mixed-method design was used: First, we used qualitative methods (focus groups, interviews) to identify a broad range of criteria important for the definition of successful RTW (N = 57). Criteria were grouped into content-related clusters. Second, we used a quantitative approach (online questionnaire) to identify, among a larger stakeholder sample (N = 178), the clusters and criteria most important for successful RTW. Results A total of 11 clusters, consisting of 52 unique criteria, were identified. In defining successful RTW, supervisors and occupational physicians regarded “Sustainability” and “At-work functioning” most important, while employees regarded “Sustainability,” “Job satisfaction,” “Work-home balance,” and “Mental Functioning” most important. Despite agreement on the importance of certain criteria, considerable differences among stakeholders were observed. Conclusions Key stakeholders vary in the aspects and criteria they regard as important when defining successful RTW after CMD-related sickness absence. Current definitions of RTW outcomes used in scientific research may not accurately reflect these key stakeholder perspectives. Future studies should be more aware of the perspective from which they aim to evaluate the effectiveness of a RTW intervention, and define their RTW outcomes accordingly. PMID:22768180

Toward diversity-responsive medical education: taking an intersectionality-based approach to a curriculum evaluation.

PubMed

Muntinga, M E; Krajenbrink, V Q E; Peerdeman, S M; Croiset, G; Verdonk, P

2016-08-01

Recent years have seen a rise in the efforts to implement diversity topics into medical education, using either a 'narrow' or a 'broad' definition of culture. These developments urge that outcomes of such efforts are systematically evaluated by mapping the curriculum for diversity-responsive content. This study was aimed at using an intersectionality-based approach to define diversity-related learning objectives and to evaluate how biomedical and sociocultural aspects of diversity were integrated into a medical curriculum in the Netherlands. We took a three-phase mixed methods approach. In phase one and two, we defined essential learning objectives based on qualitative interviews with school stakeholders and diversity literature. In phase three, we screened the written curriculum for diversity content (culture, sex/gender and class) and related the results to learning objectives defined in phase two. We identified learning objectives in three areas of education (medical knowledge and skills, patient-physician communication, and reflexivity). Most diversity content pertained to biomedical knowledge and skills. Limited attention was paid to sociocultural issues as determinants of health and healthcare use. Intersections of culture, sex/gender and class remained mostly unaddressed. The curriculum's diversity-responsiveness could be improved by an operationalization of diversity that goes beyond biomedical traits of assumed homogeneous social groups. Future efforts to take an intersectionality-based approach to curriculum evaluations should include categories of difference other than culture, sex/gender and class as separate, equally important patient identities or groups.

Athletic Departments' Operating Expenses as a Predictor of Their Directors' Cup Standing

ERIC Educational Resources Information Center

Magner, Amber

2014-01-01

The NACDA Directors' Cup is a competition utilizing an unbiased scoring system that encourages a broad based athletic department as the standard for defining intercollegiate athletic success. Therefore, for NCAA DI athletic administrators the Directors' Cup should be the standard for defining intercollegiate athletic success. The purpose of this…

Family Violence and Associated Help-Seeking Behavior among Older African American Women

PubMed Central

Paranjape, Anuradha; Tucker, Alyce; Mckenzie-Mack, LaTasha; Thompson, Nancy; Kaslow, Nadine

2007-01-01

Objective Little is known about how older African American women define family violence (FV) and what FV survivors might expect from their healthcare providers. The purpose of this study was to understand how these women define FV, where they seek help for FV, and what barriers they face in these efforts. Methods We conducted 6 focus groups with 30 African American women over the age of 50, including some FV survivors, at a large, inner-city public hospital. Results Participants defined FV broadly, citing examples of abuse (physical, sexual, emotional and financial) and neglect. Spiritual sources were cited over physicians as being available to help FV survivors. Barriers to receiving assistance included negative encounters with physicians, lack of trust in the system and dearth of age-appropriate resources. Conclusions For older African American women, FV takes many forms of which many may not be obvious during the clinical encounter. Like younger FV survivors, they expect physicians to serve as a resource for FV. Practice implications Physicians caring for older African American women need to remember to ask them about FV, and when making referrals for abuse and neglect, consider offering referrals to pastoral care if appropriate. PMID:17644300

Why revisit your cost-accounting strategy.

PubMed

Arredondo, Ricky

2014-07-01

Healthcare entities seeking to develop effective cost-accounting systems should take six steps to avoid potential pitfalls: Secure broad executive-level support for the effort. Ensure systems are in place to analyze the disparate data. Define measurable objectives to ensure that implementation achieves desired results. Give due consideration to implementation planning. Train support staff sufficiently to avoid underutilization. Develop a sufficiently broad base of staff support for the system.

An empirical broad spectrum antibiotic therapy in health-care-associated infections improves survival in patients with cirrhosis: A randomized trial.

PubMed

Merli, Manuela; Lucidi, Cristina; Di Gregorio, Vincenza; Lattanzi, Barbara; Giannelli, Valerio; Giusto, Michela; Farcomeni, Alessio; Ceccarelli, Giancarlo; Falcone, Marco; Riggio, Oliviero; Venditti, Mario

2016-05-01

Early diagnosis and appropriate treatment of infections in cirrhosis are crucial because of their high morbidity and mortality. Multidrug-resistant (MDR) infections are on the increase in health care settings. Health-care-associated (HCA) infections are still frequently treated as community-acquired with a detrimental effect on survival. We aimed to prospectively evaluate in a randomized trial the effectiveness of a broad spectrum antibiotic treatment in patients with cirrhosis with HCA infections. Consecutive patients with cirrhosis hospitalized with HCA infections were enrolled. After culture sampling, patients were promptly randomized to receive a standard or a broad spectrum antibiotic treatment (NCT01820026). The primary endpoint was in-hospital mortality. Efficacy, side effects, and the length of hospitalization were considered. Treatment failure was followed by a change in antibiotic therapy. Ninety-six patients were randomized and 94 were included. The two groups were similar for demographic, clinical, and microbiological characteristics. The prevalence of MDR pathogens was 40% in the standard versus 46% in the broad spectrum group. In-hospital mortality showed a substantial reduction in the broad spectrum versus standard group (6% vs. 25%; P = 0.01). In a post-hoc analysis, reduction of mortality was more evident in patients with sepsis. The broad spectrum showed a lower rate of treatment failure than the standard therapy (18% vs. 51%; P = 0.001). Length of hospitalization was shorter in the broad spectrum (12.3 ± 7 days) versus standard group (18 ± 15 days; P = 0.03). Five patients in each group developed a second infection during hospitalization with a similar prevalence of MDR (50% broad spectrum vs. 60% standard). A broad spectrum antibiotic therapy as empirical treatment in HCA infections improves survival in cirrhosis. This treatment was significantly effective, safe, and cost saving. © 2015 by the American Association for the Study of Liver Diseases.

Defining competency-based evaluation objectives in family medicine

PubMed Central

Lawrence, Kathrine; Allen, Tim; Brailovsky, Carlos; Crichton, Tom; Bethune, Cheri; Donoff, Michel; Laughlin, Tom; Wetmore, Stephen; Carpentier, Marie-Pierre; Visser, Shaun

2011-01-01

Abstract Objective To develop key features for priority topics previously identified by the College of Family Physicians of Canada that, together with skill dimensions and phases of the clinical encounter, broadly describe competence in family medicine. Design Modified nominal group methodology, which was used to develop key features for each priority topic through an iterative process. Setting The College of Family Physicians of Canada. Participants An expert group of 7 family physicians and 1 educational consultant, all of whom had experience in assessing competence in family medicine. Group members represented the Canadian family medicine context with respect to region, sex, language, community type, and experience. Methods The group used a modified Delphi process to derive a detailed operational definition of competence, using multiple iterations until consensus was achieved for the items under discussion. The group met 3 to 4 times a year from 2000 to 2007. Main findings The group analyzed 99 topics and generated 773 key features. There were 2 to 20 (average 7.8) key features per topic; 63% of the key features focused on the diagnostic phase of the clinical encounter. Conclusion This project expands previous descriptions of the process of generating key features for assessment, and removes this process from the context of written examinations. A key-features analysis of topics focuses on higher-order cognitive processes of clinical competence. The project did not define all the skill dimensions of competence to the same degree, but it clearly identified those requiring further definition. This work generates part of a discipline-specific, competency-based definition of family medicine for assessment purposes. It limits the domain for assessment purposes, which is an advantage for the teaching and assessment of learners. A validation study on the content of this work would ensure that it truly reflects competence in family medicine. PMID:21998245

Attitudes toward euthanasia among Polish physicians, nurses and people who have no professional experience with the terminally ill.

PubMed

Glebocka, A; Gawor, A; Ostrowski, F

2013-01-01

Euthanasia is an issue that generates an extensive social debate. Euthanasia is generally classified as either active or passive. The former is usually defined as taking specific steps to cause the patient's death, while the latter is described as withdrawal of medical treatment with the deliberate intention of bringing the patient's life to an end. The dispute on euthanasia involves a multitude of aspects including religious, legal, cultural, ethical, medical, and spiritual issues. The purpose of the present study was to examine the views of medical professionals toward the highly controversial issue of euthanasia. Accordingly, the research has been conducted among a group of Polish nurses and physicians working in Intensive Care and Oncology Units. Their views have been compared to those of the control group, which included the members of the general public, who do not work in medical profession. It was expected that the education and training and the day-to-day exposure to vegetative patients might influence the views of medical personnel concerning euthanasia. The research demonstrated that the members of all groups supported liberal views. Conservative views were not popular among the respondents. The physicians turned out to be the least conservative group. The survey has also demonstrated that there is a broad consensus that informational and psychological support should be provided to terminally ill patients and their relatives. The attitude toward the passive form of euthanasia seems to have broad support. In particular doctors tend to approve this form of bringing a terminally ill patient's life to an end. The active euthanasia is regarded with much less favor and physicians, in particular, appear to disapprove of it.

A method for deriving leading causes of death.

PubMed Central

Becker, Roberto; Silvi, John; Ma Fat, Doris; L'Hours, André; Laurenti, Ruy

2006-01-01

OBJECTIVE: A standard list for ranking leading causes of death worldwide does not exist. WHO headquarters, regional offices and Member States all use different lists that have varying levels of detail. We sought to derive a standard list to enable countries to identify their leading causes of death and to permit comparison between countries. Our aim is to share the criteria and methodology we used to bring some order to the construction of such a list, to provide a consistent procedure that can be used by others, and to give researchers and data owners an opportunity to utilize the list at national and subnational levels. METHODS: Results were primarily data-driven. Data from individual countries representing different regions of the world were extracted from the WHO Mortality Database. Supplementary information from WHO estimates on mortality was used for regions where data were scarce. In addition, a set of criteria was used to group the candidate causes and to determine other causes that should be included on the list. FINDINGS: A ranking list of the leading causes of death that contains broad cause groupings (such as "all cancers", "all heart diseases" or "all accidents") is not effective and does not identify the leading individual causes within these broad groupings; thus it does not allow policy-makers to generate appropriate health advocacy and cost-effective interventions. Similarly, defining candidate causal groups too narrowly or including diseases that have a low frequency does not meet these objectives. CONCLUSION: For international comparisons, we recommend that countries use this list; it is based on extensive evidence and the application of public health disease-prevention criteria. It is not driven by political or financial motives. This list may be adapted for national statistical purposes. PMID:16628303

A cost analysis of a broad-spectrum antibiotic therapy in the empirical treatment of health care-associated infections in cirrhotic patients

PubMed Central

Lucidi, Cristina; Di Gregorio, Vincenza; Ceccarelli, Giancarlo; Venditti, Mario; Riggio, Oliviero; Merli, Manuela

2017-01-01

Background Early diagnosis and appropriate treatment of infections in cirrhosis are crucial. As new guidelines in this context, particularly for health care-associated (HCA) infections, would be needed, we performed a trial documenting whether an empirical broad-spectrum antibiotic therapy is more effective than the standard one for these infections. Because of the higher daily cost of broad-spectrum than standard antibiotics, we performed a cost analysis to compare: 1) total drug costs, 2) profitability of hospital admissions. Methods This retrospective observational analysis was performed on patients enrolled in the trial NCT01820026, in which consecutive cirrhotic patients with HCA infections were randomly assigned to a standard vs a broad-spectrum treatment. Antibiotic daily doses, days of treatment, length of hospital stay, and DRG (diagnosis-related group) were recorded from the clinical trial medical records. The profitability of hospitalizations was calculated considering DRG tariffs divided by length of hospital stay. Results We considered 84 patients (42 for each group). The standard therapy allowed to obtain a first-line treatment cost lower than in the broad-spectrum therapy. Anyway, the latter, being related to a lower failure rate (19% vs 57.1%), resulted in cost saving in terms of cumulative antibiotic costs (first- and second-line treatments). The mean cost saving per patient for the broad-spectrum arm was €44.18 (−37.6%), with a total cost saving of about €2,000. Compared to standard group, we observed a statistically significant reduction in hospital stay from 17.8 to 11.8 days (p<0.002) for patients treated with broad-spectrum antibiotics. The distribution of DRG tariffs was similar in the two groups. According to DRG, the shorter length of hospital stay of the broad-spectrum group involved a higher mean profitable daily cost than standard group (€345.61 vs €252.23; +37%). Conclusion Our study supports the idea that the use of a broad-spectrum empirical treatment for HCA infections in cirrhosis would be cost-saving and that hospitals need to be aware of the clinical and economic consequences of a wrong antibiotic treatment in this setting. PMID:28721080

A cost analysis of a broad-spectrum antibiotic therapy in the empirical treatment of health care-associated infections in cirrhotic patients.

PubMed

Lucidi, Cristina; Di Gregorio, Vincenza; Ceccarelli, Giancarlo; Venditti, Mario; Riggio, Oliviero; Merli, Manuela

2017-01-01

Early diagnosis and appropriate treatment of infections in cirrhosis are crucial. As new guidelines in this context, particularly for health care-associated (HCA) infections, would be needed, we performed a trial documenting whether an empirical broad-spectrum antibiotic therapy is more effective than the standard one for these infections. Because of the higher daily cost of broad-spectrum than standard antibiotics, we performed a cost analysis to compare: 1) total drug costs, 2) profitability of hospital admissions. This retrospective observational analysis was performed on patients enrolled in the trial NCT01820026, in which consecutive cirrhotic patients with HCA infections were randomly assigned to a standard vs a broad-spectrum treatment. Antibiotic daily doses, days of treatment, length of hospital stay, and DRG (diagnosis-related group) were recorded from the clinical trial medical records. The profitability of hospitalizations was calculated considering DRG tariffs divided by length of hospital stay. We considered 84 patients (42 for each group). The standard therapy allowed to obtain a first-line treatment cost lower than in the broad-spectrum therapy. Anyway, the latter, being related to a lower failure rate (19% vs 57.1%), resulted in cost saving in terms of cumulative antibiotic costs (first- and second-line treatments). The mean cost saving per patient for the broad-spectrum arm was €44.18 (-37.6%), with a total cost saving of about €2,000. Compared to standard group, we observed a statistically significant reduction in hospital stay from 17.8 to 11.8 days ( p <0.002) for patients treated with broad-spectrum antibiotics. The distribution of DRG tariffs was similar in the two groups. According to DRG, the shorter length of hospital stay of the broad-spectrum group involved a higher mean profitable daily cost than standard group (€345.61 vs €252.23; +37%). Our study supports the idea that the use of a broad-spectrum empirical treatment for HCA infections in cirrhosis would be cost-saving and that hospitals need to be aware of the clinical and economic consequences of a wrong antibiotic treatment in this setting.

Evaluation of empiric antibiotic de-escalation in febrile neutropenia.

PubMed

Kroll, Amanda L; Corrigan, Patricia A; Patel, Shejal; Hawks, Kelly G

2016-10-01

Up until 2010, the recommended duration of empiric broad-spectrum antibiotics for febrile neutropenia was until absolute neutrophil count (ANC) recovery. An updated guideline on the use of antimicrobial agents in neutropenic patients with cancer indicates that patients who have completed an appropriate treatment course of broad-spectrum antibiotics, with resolution of signs and symptoms of infection but persistent neutropenia, can be de-escalated to oral fluoroquinolone prophylaxis until ANC recovery. The primary objective of this retrospective investigation was to evaluate the safety and efficacy of de-escalating broad-spectrum antibiotics in patients remaining neutropenic after at least 14 days of empiric broadspectrum antibiotics for febrile neutropenia compared to patients continuing broad-spectrum antibiotics until ANC recovery. There were 16 patients (61.5%) in the comparator group who met the primary endpoint of remaining afebrile and without escalation of antibiotics for at least 72 hours after 14 days of broad-spectrum antibiotics and 21 patients (80.7%) in the de-escalation group who met the primary endpoint of remaining afebrile and without reinitiation of broad-spectrum antibiotics for at least 72 hours after de-escalation to levofloxacin therapy (p = 0.11). Mean total duration of broad-spectrum antibiotic therapy was 23.5 ± 1.5 days in the comparator group versus 22.2 ± 1.43 days in the de-escalation group (p = 0.39). Results of this investigation indicate that broad-spectrum antibiotics can be safely de-escalated to levofloxacin prophylaxis prior to ANC recovery in select patients. This practice may decrease the duration of broad-spectrum antibiotic exposure and associated complications. © The Author(s) 2015.

The Impact of Project 2061 on Science Education in Northeastern Louisiana Classrooms.

ERIC Educational Resources Information Center

Webb, Paula Bauer; Pugh, Ava F.

Project 2061, a broad-based science reform movement, was launched by the American Association for the Advancement of Science, the Carnegie Corporation of New York, and the Andrew W. Mellon Foundation to define the fundamental science and mathematics American students should know. A second phase of Project 2061 translated the defined learning goals…

Space station systems analysis study. Part 3: Documentation. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

The space stations systems analysis study is summarized. A cost efffective system concept capable of meeting a broad spectrum of mission requirements was developed. Candidate objectives were reviewed and implementation requirements were defined. Program options for both low earth and geosynchronous orbits were examined. Space construction concepts were analyzed and defined in detail.

A trait based approach to defining valued mentoring qualities

NASA Astrophysics Data System (ADS)

Pendall, E.

2012-12-01

Graduate training in the sciences requires strong personal interactions among faculty, senior lab members and more junior members. Within the lab-group setting we learn to frame problems, to conduct research and to communicate findings. The result is that individual scientists are partly shaped by a few influential mentors. We have all been influenced by special relationships with mentors, and on reflection we may find that certain qualities have been especially influential in our career choices. In this presentation I will discuss favorable mentoring traits as determined from an informal survey of scientists in varying stages of careers and from diverse backgrounds. Respondents addressed questions about traits they value in their mentors in several categories: 1) personal qualities such as approachability, humor and encouragement; background including gender, ethnicity, and family status; 2) scientific qualities including discipline or specialization, perceived stature in discipline, seniority, breadth of perspective, and level of expectations; and 3) community-oriented qualities promoted by mentors, such as encouraging service contributions and peer-mentoring within the lab group. The results will be compared among respondents by gender, ethnicity, stage of career, type of work, and subdiscipline within the broadly defined Biogeoscience community. We hope to contribute to the growing discussion on building a diverse and balanced scientific workforce.

Broad-Enrich: functional interpretation of large sets of broad genomic regions.

PubMed

Cavalcante, Raymond G; Lee, Chee; Welch, Ryan P; Patil, Snehal; Weymouth, Terry; Scott, Laura J; Sartor, Maureen A

2014-09-01

Functional enrichment testing facilitates the interpretation of Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) data in terms of pathways and other biological contexts. Previous methods developed and used to test for key gene sets affected in ChIP-seq experiments treat peaks as points, and are based on the number of peaks associated with a gene or a binary score for each gene. These approaches work well for transcription factors, but histone modifications often occur over broad domains, and across multiple genes. To incorporate the unique properties of broad domains into functional enrichment testing, we developed Broad-Enrich, a method that uses the proportion of each gene's locus covered by a peak. We show that our method has a well-calibrated false-positive rate, performing well with ChIP-seq data having broad domains compared with alternative approaches. We illustrate Broad-Enrich with 55 ENCODE ChIP-seq datasets using different methods to define gene loci. Broad-Enrich can also be applied to other datasets consisting of broad genomic domains such as copy number variations. http://broad-enrich.med.umich.edu for Web version and R package. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

A Standard System to Study Vertebrate Embryos

PubMed Central

Werneburg, Ingmar

2009-01-01

Staged embryonic series are important as reference for different kinds of biological studies. I summarise problems that occur when using ‘staging tables’ of ‘model organisms’. Investigations of developmental processes in a broad scope of taxa are becoming commonplace. Beginning in the 1990s, methods were developed to quantify and analyse developmental events in a phylogenetic framework. The algorithms associated with these methods are still under development, mainly due to difficulties of using non-independent characters. Nevertheless, the principle of comparing clearly defined newly occurring morphological features in development (events) in quantifying analyses was a key innovation for comparative embryonic research. Up to date no standard was set for how to define such events in a comparative approach. As a case study I compared the external development of 23 land vertebrate species with a focus on turtles, mainly based on reference staging tables. I excluded all the characters that are only identical for a particular species or general features that were only analysed in a few species. Based on these comparisons I defined 104 developmental characters that are common either for all vertebrates (61 characters), gnathostomes (26), tetrapods (3), amniotes (7), or only for sauropsids (7). Characters concern the neural tube, somite, ear, eye, limb, maxillary and mandibular process, pharyngeal arch, eyelid or carapace development. I present an illustrated guide listing all the defined events. This guide can be used for describing developmental series of any vertebrate species or for documenting specimen variability of a particular species. The guide incorporates drawings and photographs as well as consideration of species identifying developmental features such as colouration. The simple character-code of the guide is extendable to further characters pertaining to external and internal morphological, physiological, genetic or molecular development, and also for other vertebrate groups not examined here, such as Chondrichthyes or Actinopterygii. An online database to type in developmental events for different stages and species could be a basis for further studies in comparative embryology. By documenting developmental events with the standard code, sequence heterochrony studies (i.e. Parsimov) and studies on variability can use this broad comparative data set. PMID:19521537

Altered dynamics of broad-leaved tree species in a Chinese subtropical montane mixed forest: the role of an anomalous extreme 2008 ice storm episode.

PubMed

Ge, Jielin; Xiong, Gaoming; Wang, Zhixian; Zhang, Mi; Zhao, Changming; Shen, Guozhen; Xu, Wenting; Xie, Zongqiang

2015-04-01

Extreme climatic events can trigger gradual or abrupt shifts in forest ecosystems via the reduction or elimination of foundation species. However, the impacts of these events on foundation species' demography and forest dynamics remain poorly understood. Here we quantified dynamics for both evergreen and deciduous broad-leaved species groups, utilizing a monitoring permanent plot in a subtropical montane mixed forest in central China from 2001 to 2010 with particular relevance to the anomalous 2008 ice storm episode. We found that both species groups showed limited floristic alterations over the study period. For each species group, size distribution of dead individuals approximated a roughly irregular and flat shape prior to the ice storm and resembled an inverse J-shaped distribution after the ice storm. Furthermore, patterns of mortality and recruitment displayed disequilibrium behaviors with mortality exceeding recruitment for both species groups following the ice storm. Deciduous broad-leaved species group accelerated overall diameter growth, but the ice storm reduced evergreen small-sized diameter growth. We concluded that evergreen broad-leaved species were more susceptible to ice storms than deciduous broad-leaved species, and ice storm events, which may become more frequent with climate change, might potentially threaten the perpetuity of evergreen-dominated broad-leaved forests in this subtropical region in the long term. These results underscore the importance of long-term monitoring that is indispensible to elucidate causal links between forest dynamics and climatic perturbations.

Altered dynamics of broad-leaved tree species in a Chinese subtropical montane mixed forest: the role of an anomalous extreme 2008 ice storm episode

PubMed Central

Ge, Jielin; Xiong, Gaoming; Wang, Zhixian; Zhang, Mi; Zhao, Changming; Shen, Guozhen; Xu, Wenting; Xie, Zongqiang

2015-01-01

Extreme climatic events can trigger gradual or abrupt shifts in forest ecosystems via the reduction or elimination of foundation species. However, the impacts of these events on foundation species' demography and forest dynamics remain poorly understood. Here we quantified dynamics for both evergreen and deciduous broad-leaved species groups, utilizing a monitoring permanent plot in a subtropical montane mixed forest in central China from 2001 to 2010 with particular relevance to the anomalous 2008 ice storm episode. We found that both species groups showed limited floristic alterations over the study period. For each species group, size distribution of dead individuals approximated a roughly irregular and flat shape prior to the ice storm and resembled an inverse J-shaped distribution after the ice storm. Furthermore, patterns of mortality and recruitment displayed disequilibrium behaviors with mortality exceeding recruitment for both species groups following the ice storm. Deciduous broad-leaved species group accelerated overall diameter growth, but the ice storm reduced evergreen small-sized diameter growth. We concluded that evergreen broad-leaved species were more susceptible to ice storms than deciduous broad-leaved species, and ice storm events, which may become more frequent with climate change, might potentially threaten the perpetuity of evergreen-dominated broad-leaved forests in this subtropical region in the long term. These results underscore the importance of long-term monitoring that is indispensible to elucidate causal links between forest dynamics and climatic perturbations. PMID:25897387

Power, Profits, and Politics: Energy Security and Cooperation in Eurasia

NASA Astrophysics Data System (ADS)

Svyatets, Ekaterina

This study explores varying outcomes of energy cooperation, defined as diplomatic relations, bilateral trade, and investment in oil and natural gas. Tests of theories pertinent to energy security - broadly speaking, realism, liberalism, and domestic politics---reveal that they alone can offer only a narrow and one-sided explanation, not embracing the complexity of energy issues. Nevertheless, using them as a starting point, this study outlined a structured framework that incorporates three variables---economic potential, geopolitical rivalry, and domestic interest groups---that are applied to the cases of U.S.-Russia, U.S.-Azerbaijan, and Russia-Germany energy ties. This study concludes that if the economic potential (defined by geographic proximity and resource availability) is very high, such as in the case of Russia-Germany, states can overcome geopolitical rivalries and historical enmities in favor of energy cooperation. However, if the economic potential is relatively low (because of geographic obstacles or easily available alternative suppliers, as in the cases of U.S.-Russia and U.S.-Azerbaijan), then geopolitics prevails---for example, to bypass Russia or to limit American access to contracts in Russia when U.S.-Russian relations are strained. In all the cases explored here, domestic interest groups have mixed influence: if they are united along energy issues, they usually successfully achieve their energy policy goals, although the impact of these groups often becomes intertwined with state interests. In other situations, when powerful interest groups are divided or focused on non-energy-related issues (such as ethnic priorities), their influence over energy deals is much lower.

Systematic mapping review of the factors influencing dietary behaviour in ethnic minority groups living in Europe: a DEDIPAC study.

PubMed

Osei-Kwasi, Hibbah Araba; Nicolaou, Mary; Powell, Katie; Terragni, Laura; Maes, Lea; Stronks, Karien; Lien, Nanna; Holdsworth, Michelle

2016-07-28

Europe has a growing population of ethnic minority groups whose dietary behaviours are potentially of public health concern. To promote healthier diets, the factors driving dietary behaviours need to be understood. This review mapped the broad range of factors influencing dietary behaviour among ethnic minority groups living in Europe, in order to identify research gaps in the literature to guide future research. A systematic mapping review was conducted (protocol registered with PROSPERO 2014: CRD42014013549). Nine databases were searched for quantitative and qualitative primary research published between 1999 and 2014. Ethnic minority groups were defined as immigrants/populations of immigrant background from low and middle income countries, population groups from former Eastern Bloc countries and minority indigenous populations. In synthesizing the findings, all factors were sorted and structured into emerging clusters according to how they were seen to relate to each other. Thirty-seven of 2965 studies met the inclusion criteria (n = 18 quantitative; n = 19 qualitative). Most studies were conducted in Northern Europe and were limited to specific European countries, and focused on a selected number of ethnic minority groups, predominantly among populations of South Asian origin. The 63 factors influencing dietary behaviour that emerged were sorted into seven clusters: social and cultural environment (16 factors), food beliefs and perceptions (11 factors), psychosocial (9 factors), social and material resources (5 factors), accessibility of food (10 factors), migration context (7 factors), and the body (5 factors). This review identified a broad range of factors and clusters influencing dietary behaviour among ethnic minority groups. Gaps in the literature identified a need for researchers to explore the underlying mechanisms that shape dietary behaviours, which can be gleaned from more holistic, systems-based studies exploring relationships between factors and clusters. The dominance of studies exploring 'differences' between ethnic minority groups and the majority population in terms of the socio-cultural environment and food beliefs suggests a need for research exploring 'similarities'. The evidence from this review will feed into developing a framework for the study of factors influencing dietary behaviours in ethnic minority groups in Europe.

The design of a long-range megatransport aircraft

NASA Technical Reports Server (NTRS)

Weisshaar, Terrence A.; Allen, Carl L.

1992-01-01

Aircraft manufacturers are examining the market and feasibility of long-range passenger aircraft carrying more than 600 passengers. These aircraft would carry travelers at reduced cost and, at the same time, reduce congestion around major airports. The design of a large, long-range transport involves broad issues such as: the integration of airport terminal facilities; passenger loading and unloading; trade-offs between aircraft size and the cost to reconfigure these existing facilities; and, defeating the 'square-cube' law. Thirteen Purdue design teams generated RFP's that defined passenger capability and range, based upon team perception of market needs and infrastructure constraints. Turbofan engines were designed by each group to power these aircraft. The design problem and the variety of solutions developed are reviewed.

Prevalence of Child Sexual Abuse in the Nordic Countries: A Literature Review.

PubMed

Kloppen, Kathrine; Haugland, Siren; Svedin, Carl Göran; Mæhle, Magne; Breivik, Kyrre

2016-01-01

This review examined child sexual abuse in the Nordic countries focusing on prevalence rates and victims' age and relationship to the perpetrator. The results show a prevalence of child sexual abuse (broadly defined) between 3-23% for boys and 11-36% for girls. The prevalence rates for contact abuse were 1-12% for boys and 6-30% for girls, while 0.3-6.8% of the boys and 1.1-13.5% of the girls reported penetrating abuse. The findings suggest an increased risk of abuse from early adolescence. In adolescence, peers may constitute the largest group of perpetrators. The results highlight the need for preventive efforts also targeting peer abuse. Future research should include cross-national and repeated studies using comparable methodology.

National Aeronautics and Space Administration fundamental research program. Information utilization and evaluation

NASA Technical Reports Server (NTRS)

Estes, J. E.; Eisgruber, L.

1981-01-01

In the second half of the 1980's NASA can expect to face difficult choices among alternative fundamental and applied research, and development projects that could potentially lead to improvements in the information systems used to manage renewable resources. The working group on information utilization and evaluation believes that effective choices cannot be made without a better understanding of the current and prospective problems and opportunities involved in the application of remote sensing to improve renewable research information systems. A renewable resources information system is defined in a broad context to include a flow of data/information from: acquisition through processing, storage, integration with other data, analysis, graphic presentation, decision making, and assessment of the affects of those decisions.

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor suppressor genes

PubMed Central

Chen, Kaifu; Chen, Zhong; Wu, Dayong; Zhang, Lili; Lin, Xueqiu; Su, Jianzhong; Rodriguez, Benjamin; Xi, Yuanxin; Xia, Zheng; Chen, Xi; Shi, Xiaobing; Wang, Qianben; Li, Wei

2016-01-01

Tumor suppressors are mostly defined by inactivating mutations in tumors, yet little is known about their epigenetic features in normal cells. Through integrative analysis of 1,134 genome-wide epigenetic profiles, mutations from >8,200 tumor-normal pairs, and our experimental data from clinical samples, we discovered broad H3K4me3 (wider than 4 kb) as the first epigenetic signature for tumor suppressors in normal cells. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity together leading to exceptionally high gene expression, and is distinct from other broad epigenetic features, such as super-enhancers. Broad H3K4me3 conserved across normal cells may represent pan-cancer tumor suppressors, such as P53 and PTEN, whereas cell-type-specific broad H3K4me3 may indicate cell-identity genes and cell-type-specific tumor suppressors. Furthermore, widespread shortening of broad H3K4me3 in cancers is associated with repression of tumor suppressors. Together, the broad H3K4me3 epigenetic signature provides mutation-independent information for the discovery and characterization of novel tumor suppressors. PMID:26301496

Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults.

PubMed

Siddiqui, Shahla; Razzak, Junaid

2010-10-06

Severe sepsis and septic shock have recently emerged as particularly acute and lethal challenges amongst critically ill patients presenting to the emergency department (ED). There are no existing data on the current practices of management of patients with severe sepsis comparing early versus late administration of appropriate broad spectrum antibiotics as part of the early goal-directed therapy that is commenced in the first few hours of presentation. To assess the difference in outcomes with early compared to late administration of antibiotics in patients with severe sepsis in the pre-intensive care unit (ICU) admission period. We defined early as within one hour of presentation to the ED. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1, 2009); MEDLINE (1990 to February 2010); EMBASE (1990 to February 2010); and ISI web of Science (February 2010). We also searched for relevant ongoing trials in specific websites such as www.controlled-trials.com; www.clinicalstudyresults.org; and www.update-software.com. We searched the reference lists of articles. There were no constraints based on language or publication status. We planned to include randomized controlled trials of early versus late broad spectrum antibiotics in adult patients with severe sepsis in the ED, prior to admission to the intensive care unit. Two authors independently assessed articles for inclusion. We found no studies that satisfied the inclusion criteria. Based on this review we are unable to make a recommendation on the early or late use of broad spectrum antibiotics in adult patients with severe sepsis in the ED pre-ICU admission. There is a need to do large prospective double blinded randomized controlled trials on the efficacy of early (within one hour) versus late broad spectrum antibiotics in adult severe sepsis patients. Since it makes sense to start antibiotics as soon as possible in this group of seriously ill patients, administering such antibiotics earlier as opposed to later is based on anecdotal suboptimal evidence.

Distribution and community structure of ichthyoplankton in Laguna Madre seagrass meadows: Potential impact of seagrass species change

USGS Publications Warehouse

Tolan, J.M.; Holt, S.A.; Onuf, C.P.

1997-01-01

Seasonal ichthyoplankton surveys were made in the lower Laguna Madre, Texas, to compare the relative utilization of various nursery habitats (shoal grass, Halodule wrightii; manatee grass, Syringodium filiforme;, and unvegetated sand bottom) for both estuarine and offshore-spawned larvae. The species composition and abundance of fish larvae were determined for each habitat type at six locations in the bay. Pushnet ichthyoplankton sampling resulted in 296 total collections, yielding 107,463 fishes representing 55 species in 24 families. A broad spectrum of both the biotic and physical habitat parameters were examined to link the dispersion and distribution of both pre-settlement and post-settlement larvae to the utilization of shallow seagrass habitats. Sample sites were grouped by cluster analysis (Ward's minimum variance method) according to the similarity of their fish assemblages and subsequently examined with a multiple discriminant function analysis to identify important environmental variables. Abiotic environmental factors were most influential in defining groups for samples dominated by early larvae, whereas measures of seagrass complexity defined groups dominated by older larvae and juveniles. Juvenile-stage individuals showed clear habitat preference, with the more shallow Halodule wrightii being the habitat of choice, whereas early larvae of most species were widely distributed over all habitats. As a result of the recent shift of dominance from Halodule wrightii to Syringodium filiforme, overall reductions in the quality of nursery habitat for fishes in the lower Laguna Madre are projected.

Raised incidence rates of all psychoses among migrant groups: findings from the East London first episode psychosis study.

PubMed

Coid, Jeremy W; Kirkbride, James B; Barker, Dave; Cowden, Fiona; Stamps, Rebekah; Yang, Min; Jones, Peter B

2008-11-01

Certain black and minority ethnic groups are at increased risk for psychoses. It is unknown whether risk for second- and later-generation black and minority ethnic groups in the United Kingdom is universally increased or varies by ethnicity, population structure, or diagnostic category. To examine whether excess risk in black and minority ethnic groups varies by generation status and to determine whether this is explained solely by an excess of broadly defined schizophrenia. Population-based epidemiological survey of first-onset psychoses during a 2-year study period. Three inner-city boroughs in East London, England. Patients Four hundred eighty-four patients with first-episode psychosis aged 18 to 64 years. Nonaffective or affective psychoses according to the DSM-IV. Raised incidence of both nonaffective and affective psychoses were found for all of the black and minority ethnic subgroups compared with white British individuals. The risk of nonaffective psychoses for first and second generations varied by ethnicity (likelihood ratio test, P = .06). Only black Caribbean second-generation individuals were at significantly greater risk compared with their first-generation counterparts (incidence rate ratio, 2.2; 95% confidence interval, 1.1-4.2) [corrected]. No significant differences between first and second generations were observed in other ethnic groups. Asian women but not men of both generations were at increased risk for psychoses compared with white British individuals. Patterns were broadly upheld for the affective psychoses. Both first- and second-generation immigrants were at elevated risk for both nonaffective and affective psychoses, but this varied by ethnicity. Our results suggest that given the same age structure, the risk of psychoses in first and second generations of the same ethnicity will be roughly equal. We suggest that socioenvironmental factors operate differentially by ethnicity but not generation status, even if the exact specification of these stressors differs across generations. Research should focus on differential rates of psychoses by ethnicity rather than between generations.

[Normal microflora of the pharyngeal mucosa].

PubMed

Kolotilova, L V; Akishina, T M; Zargarian, O P; Lomnitskaia, V B; Pruzhniak, O V; Lutsik, T S

1989-10-01

Aerobic microflora of the throat mucosa was studied in 518 healthy persons aged 1 to 50 years. On the basis of the study results, criteria for estimating microbiocenoses of the upper respiratory tracts were defined. It was shown that the throat symbiotic flora included three groups of microorganisms playing different roles in the development of microbiocenosis. The indigenous group consisted of representatives of Streptococcus and Neisseria and was characterized by permanent (90-100 per cent) and intensive (3-8 lg CFU/ml) colonization, broad species spectrum, associations of 2-3 and more species and no significant influence of sociological, age and season factors. The representatives of the facultative group i.e. bacteria belonging to Staphylococcus, Corynebacterium and Haemophilus were less frequent (25-50 per cent). The intensity of their isolation was lower (1-4 lg CFU/ml) and their species spectrum was narrow. The microorganisms of the transitory group were characterized by low frequency (5-20 per cent) and insignificant contamination of the throat mucosa (1-2 lg CFU/ml). The nature of the colonization was monospecific. The group was more numerous by generic composition (Candida, Escherichia, Klebsiella, Citrobacter, Enterobacter, Pseudomonas, Branhamella, Moraxella and Micrococcus). However, it was generally limited by one colonization type. The facultative and transitory groups were subject to age and season variation. They were also different in urban and rural populations.

Statistical learning in songbirds: from self-tutoring to song culture.

PubMed

Fehér, Olga; Ljubičić, Iva; Suzuki, Kenta; Okanoya, Kazuo; Tchernichovski, Ofer

2017-01-05

At the onset of vocal development, both songbirds and humans produce variable vocal babbling with broadly distributed acoustic features. Over development, these vocalizations differentiate into the well-defined, categorical signals that characterize adult vocal behaviour. A broadly distributed signal is ideal for vocal exploration, that is, for matching vocal production to the statistics of the sensory input. The developmental transition to categorical signals is a gradual process during which the vocal output becomes differentiated and stable. But does it require categorical input? We trained juvenile zebra finches with playbacks of their own developing song, produced just a few moments earlier, updated continuously over development. Although the vocalizations of these self-tutored (ST) birds were initially broadly distributed, birds quickly developed categorical signals, as fast as birds that were trained with a categorical, adult song template. By contrast, siblings of those birds that received no training (isolates) developed phonological categories much more slowly and never reached the same level of category differentiation as their ST brothers. Therefore, instead of simply mirroring the statistical properties of their sensory input, songbirds actively transform it into distinct categories. We suggest that the early self-generation of phonological categories facilitates the establishment of vocal culture by making the song easier to transmit at the micro level, while promoting stability of shared vocabulary at the group level over generations.This article is part of the themed issue 'New frontiers for statistical learning in the cognitive sciences'. © 2016 The Authors.

Cognition- and Dementia-Related Adverse Effects With Sacubitril-Valsartan: Analysis of the FDA Adverse Event Report System Database.

PubMed

Perlman, Amichai; Hirsh Raccah, Bruria; Matok, Ilan; Muszkat, Mordechai

2018-05-07

Because neprilysin is involved in the degradation of amyloid-beta, there is concern that the angiotensin-neprilysin inhibitor sacubitril-valsartan could increase the risk for dementia. We analyzed adverse event cases submitted to the Food and Drug Administration Adverse Event Report System from July 2015 to March 2017. Cognition- and dementia-related adverse event cases were defined with the use of broad and narrow structured medical queries. During the period evaluated, 9,004 adverse event reports (out of a total of 2,249,479) involved the use of sacubitril-valsartan. Based on the broad definition, sacubitril-valsartan was associated with cognition- and dementia-related adverse events in 459 reports (5.1%), but this was lower than the proportion of these reports among other medications (6.6%, reporting odds ratio [ROR] 0.72, 95% confidence interval [CI] 0.65-0.79). Restricting the comparison to cases with age >60 years and with the use of a comparator group with heart failure resulted in no association between sacubitril-valsartan and dementia-related adverse events, with the use of both the broad and the narrow definitions (ROR 0.87, 95% CI 0.76-1.02, and ROR 1.06, 95% CI 0.4-3.16, respectively). Sacubitril-valsartan is not associated with a disproportionately high rate of short-term dementia-related adverse effect reports. Long-term studies assessing cognitive outcomes are required to better establish the medication's cognition effects. Copyright © 2018 Elsevier Inc. All rights reserved.

DSM-5 AND ICD-11 DEFINITIONS OF POSTTRAUMATIC STRESS DISORDER: INVESTIGATING “NARROW” AND “BROAD” APPROACHES

PubMed Central

Stein, Dan J.; McLaughlin, Katie A.; Koenen, Karestan C.; Atwoli, Lukoye; Friedman, Matthew J.; Hill, Eric D.; Maercker, Andreas; Petukhova, Maria; Shahly, Victoria; van Ommeren, Mark; Alonso, Jordi; Borges, Guilherme; de Girolamo, Giovanni; de Jonge, Peter; Demyttenaere, Koen; Florescu, Silvia; Karam, Elie G.; Kawakami, Norito; Matschinger, Herbert; Okoliyski, Michail; Posada-Villa, Jose; Scott, Kate M.; Viana, Maria Carmen; Kessler, Ronald C.

2014-01-01

Background The development of the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and ICD-11 has led to reconsideration of diagnostic criteria for posttraumatic stress disorder (PTSD). The World Mental Health (WMH) Surveys allow investigation of the implications of the changing criteria compared to DSM-IV and ICD-10. Methods WMH Surveys in 13 countries asked respondents to enumerate all their lifetime traumatic events (TEs) and randomly selected one TE per respondent for PTSD assessment. DSMIV and ICD-10 PTSD were assessed for the 23,936 respondents who reported lifetime TEs in these surveys with the fully structured Composite International Diagnostic Interview (CIDI). DSM-5 and proposed ICD-11 criteria were approximated. Associations of the different criteria sets with indicators of clinical severity (distress-impairment, suicidality, comorbid fear-distress disorders, PTSD symptom duration) were examined to investigate the implications of using the different systems. Results A total of 5.6% of respondents met criteria for “broadly defined” PTSD (i.e., full criteria in at least one diagnostic system), with prevalence ranging from 3.0% with DSM-5 to 4.4% with ICD-10. Only one-third of broadly defined cases met criteria in all four systems and another one third in only one system (narrowly defined cases). Between-system differences in indicators of clinical severity suggest that ICD-10 criteria are least strict and DSM-IV criteria most strict. The more striking result, though, is that significantly elevated indicators of clinical significance were found even for narrowly defined cases for each of the four diagnostic systems. Conclusions These results argue for a broad definition of PTSD defined by any one of the different systems to capture all clinically significant cases of PTSD in future studies. PMID:24894802

Recovery: what does this mean to patients with low back pain?

PubMed

Hush, Julia M; Refshauge, Kathryn; Sullivan, Gerard; De Souza, Lorraine; Maher, Christopher G; McAuley, James H

2009-01-15

To explore patients' perceptions of recovery from low back pain, about which little is known. A qualitative study was conducted in which 36 participants, either recovered or unrecovered from low back pain, participated in focus groups. Interviews were audiorecorded and transcribed verbatim. Framework analysis was used to identify emergent themes and domains of recovery. Patients' views of recovery encompassed a range of factors that can be broadly classified into the domains of symptom attenuation, improved capacity to perform a broad scope of self-defined functional activities, and achievement of an acceptable quality of life. An interactive model is proposed to describe the relationships between these domains, cognitive appraisal of the pain experience, and self-rated recovery. Pain attenuation alone was not a reliable indicator of recovery. The construct of recovery for typical back pain patients seeking primary care is more complex than previously recognized and is a highly individual construct, determined by appraisal of the impact of symptoms on daily functional activities as well as quality of life factors. These findings will be valuable for reassessing how to optimize measures of recovery from low back pain by addressing the spectrum of factors patients consider meaningful.

Working More Productively: Tools for Administrative Data

PubMed Central

Roos, Leslie L; Soodeen, Ruth-Ann; Bond, Ruth; Burchill, Charles

2003-01-01

Objective This paper describes a web-based resource () that contains a series of tools for working with administrative data. This work in knowledge management represents an effort to document, find, and transfer concepts and techniques, both within the local research group and to a more broadly defined user community. Concepts and associated computer programs are made as “modular” as possible to facilitate easy transfer from one project to another. Study Setting/Data Sources Tools to work with a registry, longitudinal administrative data, and special files (survey and clinical) from the Province of Manitoba, Canada in the 1990–2003 period. Data Collection Literature review and analyses of web site utilization were used to generate the findings. Principal Findings The Internet-based Concept Dictionary and SAS macros developed in Manitoba are being used in a growing number of research centers. Nearly 32,000 hits from more than 10,200 hosts in a recent month demonstrate broad interest in the Concept Dictionary. Conclusions The tools, taken together, make up a knowledge repository and research production system that aid local work and have great potential internationally. Modular software provides considerable efficiency. The merging of documentation and researcher-to-researcher dissemination keeps costs manageable. PMID:14596394

Defining pollen exposure times for clinical trials of allergen immunotherapy for pollen-induced rhinoconjunctivitis - an EAACI position paper.

PubMed

Pfaar, O; Bastl, K; Berger, U; Buters, J; Calderon, M A; Clot, B; Darsow, U; Demoly, P; Durham, S R; Galán, C; Gehrig, R; Gerth van Wijk, R; Jacobsen, L; Klimek, L; Sofiev, M; Thibaudon, M; Bergmann, K C

2017-05-01

Clinical efficacy of pollen allergen immunotherapy (AIT) has been broadly documented in randomized controlled trials. The underlying clinical endpoints are analysed in seasonal time periods predefined based on the background pollen concentration. However, any validated or generally accepted definition from academia or regulatory authorities for this relevant pollen exposure intensity or period of time (season) is currently not available. Therefore, this Task Force initiative of the European Academy of Allergy and Clinical Immunology (EAACI) aimed to propose definitions based on expert consensus. A Task Force of the Immunotherapy and Aerobiology and Pollution Interest Groups of the EAACI reviewed the literature on pollen exposure in the context of defining relevant time intervals for evaluation of efficacy in AIT trials. Underlying principles in measuring pollen exposure and associated methodological problems and limitations were considered to achieve a consensus. The Task Force achieved a comprehensive position in defining pollen exposure times for different pollen types. Definitions are presented for 'pollen season', 'high pollen season' (or 'peak pollen period') and 'high pollen days'. This EAACI position paper provides definitions of pollen exposures for different pollen types for use in AIT trials. Their validity as standards remains to be tested in future studies. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

RE-DEFINING THE ROLES OF SENSORS IN OBJECTIVE PHYSICAL ACTIVITY MONITORING

PubMed Central

Chen, Kong Y.; Janz, Kathleen F.; Zhu, Weimo; Brychta, Robert J.

2011-01-01

Background As physical activity researchers are increasingly using objective portable devices, this review describes current state of the technology to assess physical activity, with a focus on specific sensors and sensor properties currently used in monitors and their strengths and weakness. Additional sensors and sensor properties desirable for activity measurement and best practices for users and developers also are discussed. Best Practices We grouped current sensors into three broad categories for objectively measuring physical activity: associated body movement, physiology, and context. Desirable sensor properties for measuring physical activity and the importance of these properties in relationship to specific applications are addressed, and the specific roles of transducers and data acquisition systems within the monitoring devices are defined. Technical advancements in sensors, microcomputer processors, memory storage, batteries, wireless communication, and digital filters have made monitors more usable for subjects (smaller, more stable, and longer running time) and for researchers (less costly, higher time resolution and memory storage, shorter download time, and user-defined data features). Future Directions Users and developers of physical activity monitors should learn about the basic properties of their sensors, such as range, accuracy, precision, while considering the data acquisition/filtering steps that may be critical to data quality and may influence the desirable measurement outcome(s). PMID:22157770

Effects of chemical structure on the thermodynamic efficiency of radical chain carriers for organic synthesis.

PubMed

Lin, Ching Yeh; Peh, Jessie; Coote, Michelle L

2011-03-18

The chain carrier index (CCI), defined as the ratio of the bond dissociation free energies (BDFE) of corresponding chain carrier halides and hydrides, is proposed as a measure of the thermodynamic efficiency of chain carriers for radical dehalogenation. The larger this value is relative to the corresponding value of the organic substrate, the more thermodynamically efficient the process. The chloride and bromide CCIs were evaluated at the G3(MP2)-RAD(+) level of theory for 120 different R-groups, covering a broad range of carbon-centered and noncarbon-centered species; the effects of solvent and temperature have also been studied. The broad finding from this work is that successful chain carriers generally maximize the strength of their halide (versus hydride bonds) through charge-shift bonding. As a result, the thermodynamic efficiency of a chain carrier tends to increase down the periodic table, and also with the inclusion of stronger electron donating substituents. The CCIs of carbon-centered species fall into a relatively narrow range so that, even when the CCI is maximized through inclusion of lone pair donor OMe or NMe(2) groups, the thermodynamic driving force for dehalogenation of other organic substrates is modest at best, and the process is likely to be kinetically hampered. Among the noncarbon-centered species studied, bismuth- and borane-centered compounds have some of the highest CCI values and, although their kinetics requires further optimization, these classes of compounds would be worth further investigation as tin-free radical reducing agents.

Mud cracks and dedolomitization in the Wittenoom Dolomite, Hamersley Group, Western Australia

USGS Publications Warehouse

Kargel, J.S.; Schreiber, J.F.; Sonett, C.P.

1996-01-01

Several impure dolomitic limestone beds in an outcrop of the latest Archean Wittenoom Dolomite (Hamersley Group, Western Australia) are polygonally cracked. The cracks appear to be sub-aerial desiccation features, suggesting that the known area of shallow water and locally emergent conditions extended from the far eastern part of the basin (the Carawine Dolomite) over 270 km farther west. This finding places shallow- water or emergent conditions either (1) near the middle of what Trendall (1983) defined as the probable original limits of the Hamersley Basin (Trendall's 'Pilbara Egg') or (2) near the southern edge of what Morris (1993) thought to be a broad carbonate platform which fed a deeper water sequence to the south. In any case, the Hamersley Basin in the area of Bee Gorge and eastward to the Carawine Dolomite may have been a carbonate mudflat in part with restricted circulation of sea water. The Carawine Dolomite and the Wittenoom Dolomite near Bee Gorge may have been affected by carbonate buildups along a shelf edge. Regardless of whether shallow water was widespread or local in the Hamersley basin, shallow water verging on emergence is supported by evidence of diagenetic dedolomitization under conditions of low atmospheric and hydrospheric P(O2) and precipitation of strontianite in the mud-cracked sample. Evidence of shallow water at Bee Gorge is consistent with Trendall's broad evaporite-basin model and with Morris' barred-platform model for the origin of Hamersley carbonates and banded iron-formations.

Progress toward a general species concept.

PubMed

Hausdorf, Bernhard

2011-04-01

New insights in the speciation process and the nature of "species" that accumulated in the past decade demand adjustments of the species concept. The standing of some of the most broadly accepted or most innovative species concepts in the light of the growing evidence that reproductive barriers are semipermeable to gene flow, that species can differentiate despite ongoing interbreeding, that a single species can originate polyphyletically by parallel evolution, and that uniparental organisms are organised in units that resemble species of biparental organisms is discussed. As a synthesis of ideas in existing concepts and the new insights, a generalization of the genic concept is proposed that defines species as groups of individuals that are reciprocally characterized by features that would have negative fitness effects in other groups and that cannot be regularly exchanged between groups upon contact. The benefits of this differential fitness species concept are that it classifies groups that keep differentiated and keep on differentiating despite interbreeding as species, that it is not restricted to specific mutations or mechanisms causing speciation, and that it can be applied to the whole spectrum of organisms from uni- to biparentals. © 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.

Program Incubation and Commercialization Best Practices Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, Shannon

As a reminder, the primary task of the 4C Program is to increase the commercialization rate of cleantech companies in California. Commercialization, broadly defined, is the innovation continuum of developing and introducing a new product or service into the market. For measurability, the 4C Program defines commercialization as encompassing a startup’s: (a) preparation, (b) incubation, (c) commercial-scale pilot / demonstration, and (d) first customer.

Multiple broadly synchronous km-scale exhumation episodes on different continents: implications for controlling processes

NASA Astrophysics Data System (ADS)

Green, Paul; Duddy, Ian; Japsen, Peter

2015-04-01

Numerous low temperature thermochronology studies have defined regional cooling episodes which imply removal of several km of section over areas of several 104 km2. The origin of such events has long been the subject of debate, while their reality has sometimes been questioned because of the lack of a viable mechanism. Kilometre-scale denudation at rifted margins has traditionally been interpreted as related to rifting and breakup, magnified by the flexural response to denudation of the uplifted rift flanks. But it is now clear that at many margins the post-breakup history is more complex, with km-scale uplift and erosion commonly post-dating breakup by 10s of Myr and often affecting regions many 100s of kilometres inland of the margins (Green et al., 2013; Brown et al., 2014). Numerous examples around the world of km-scale exhumation affecting regions distant from continental margins, including cratonic regions traditionally regarded as stable over Phanerozoic time (e.g. Ault et al., 2009; Flowers & Kelley, 2011), cannot be explained by margin-related mechanisms. It has also become clear that periods of exhumation are separated by episodes of burial, defining a series of positive and negative vertical movements. Previous studies have defined a broad synchroneity of Early, Middle and Late Cenozoic exhumation events in regions from Alaska to Greenland, Norway and Svalbard (Green and Duddy, 2010). New results from SE Australia define a series of exhumation episodes ranging in time from Carboniferous to Cenozoic which are broadly synchronous with similar events previously defined in Brazil and South Africa (Green et al. 2013). While estimates of the timing of exhumation in different areas are subject to some uncertainty, data across three southern hemisphere continents show a broad synchronicity in similar fashion to the northern hemisphere examples cited above. Dynamic topography has been invoked as a possible mechanism for producing uplift, the effects of which might be magnified by the isostatic response to denudation, but until recently the vertical motions expected from this mechanism were thought to be restricted to 100s of metres while expected timescales of 100s of Myr are not consistent with observations. Braun et al. (2014) showed that movement of plates over areas of areas of mantle upwelling could produce much more rapid uplift and also much larger-scale vertical movements, but the predicted diachroneity of uplift across southern Africa differs from the apparent synchroneity across three continents described here. The processes described by Braun et al. are also specific to one location and one event. Japsen et al. (2012) suggested that broadly synchronous exhumation events on divergent continents resulted from lateral resistance to plate motion driven by forces transmitted in the asthenosphere, while Colli et al. (2014) proposed that dynamic topography caused by pressure-driven mantle flow could produce synchronous uplift (and erosion) in separate continents. Such processes appear to offer more viable mechanisms for producing broadly synchronous episodes of kilometre-scale exhumation and intervening burial in regions separated by large distances. Further geodynamic modelling is needed to develop and test likely mechanisms.

PathwaySplice: An R package for unbiased pathway analysis of alternative splicing in RNA-Seq data.

PubMed

Yan, Aimin; Ban, Yuguang; Gao, Zhen; Chen, Xi; Wang, Lily

2018-04-24

Pathway analysis of alternative splicing would be biased without accounting for the different number of exons or junctions associated with each gene, because genes with higher number of exons or junctions are more likely to be included in the "significant" gene list in alternative splicing. We present PathwaySplice, an R package that (1) Performs pathway analysis that explicitly adjusts for the number of exons or junctions associated with each gene; (2) Visualizes selection bias due to different number of exons or junctions for each gene and formally tests for presence of bias using logistic regression; (3) Supports gene sets based on the Gene Ontology terms, as well as more broadly defined gene sets (e.g. MSigDB) or user defined gene sets; (4) Identifies the significant genes driving pathway significance and (5) Organizes significant pathways with an enrichment map, where pathways with large number of overlapping genes are grouped together in a network graph. https://bioconductor.org/packages/release/bioc/html/PathwaySplice.html. lily.wangg@gmail.com, xi.steven.chen@gmail.com.

A Call to Develop Course-Based Undergraduate Research Experiences (CUREs) for Nonmajors Courses

PubMed Central

Ballen, Cissy J.; Blum, Jessamina E.; Brownell, Sara; Hebert, Sadie; Hewlett, James; Klein, Joanna R.; McDonald, Erik A.; Monti, Denise L.; Nold, Stephen C.; Slemmons, Krista E.; Soneral, Paula A. G.; Cotner, Sehoya

2017-01-01

Course-based undergraduate research experiences (CUREs) for non–science majors (nonmajors) are potentially distinct from CUREs for developing scientists in their goals, learning objectives, and assessment strategies. While national calls to improve science, technology, engineering, and mathematics education have led to an increase in research revealing the positive effects of CUREs for science majors, less work has specifically examined whether nonmajors are impacted in the same way. To address this gap in our understanding, a working group focused on nonmajors CUREs was convened to discuss the following questions: 1) What are our laboratory-learning goals for nonmajors? 2) What are our research priorities to determine best practices for nonmajors CUREs? 3) How can we collaborate to define and disseminate best practices for nonmajors in CUREs? We defined three broad student outcomes of prime importance to the nonmajors CURE: improvement of scientific literacy skills, proscience attitudes, and evidence-based decision making. We evaluated the state of knowledge of best practices for nonmajors, and identified research priorities for the future. The report that follows is a summary of the conclusions and future directions from our discussion. PMID:28450449

Healthcare service quality: towards a broad definition.

PubMed

Mosadeghrad, Ali Mohammad

2013-01-01

The main purpose of this study is to define healthcare quality to encompass healthcare stakeholder needs and expectations because healthcare quality has varying definitions for clients, professionals, managers, policy makers and payers. This study represents an exploratory effort to understand healthcare quality in an Iranian context. In-depth individual and focus group interviews were conducted with key healthcare stakeholders. Quality healthcare is defined as "consistently delighting the patient by providing efficacious, effective and efficient healthcare services according to the latest clinical guidelines and standards, which meet the patient's needs and satisfies providers". Healthcare quality definitions common to all stakeholders involve offering effective care that contributes to the patient well-being and satisfaction. This study helps us to understand quality healthcare, highlighting its complex nature, which has direct implications for healthcare providers who are encouraged to regularly monitor healthcare quality using the attributes identified in this study. Accordingly, they can initiate continuous quality improvement programmes to maintain high patient-satisfaction levels. This is the first time a comprehensive healthcare quality definition has been developed using various healthcare stakeholder perceptions and expectations.

Markets on Networks

NASA Astrophysics Data System (ADS)

Toroczkai, Zoltan; Anghel, Marian; Bassler, Kevin; Korniss, Gyorgy

2003-03-01

The dynamics of human, and most biological populations is characterized by competition for resources. By its own nature, this dynamics creates the group of "elites", formed by those agents who have strategies that are the most successful in the given situation, and therefore the rest of the agents will tend to follow, imitate, or interact with them, creating a social structure of leadership in the agent society. These inter-agent communications generate a complex social network with small-world character which itself forms the substrate for a second network, the action network. The latter is a highly dynamic, adaptive, directed network, defined by those inter-agent communication links on the substrate along which the passed information /prediction is acted upon by the other agents. By using the minority game for competition dynamics, here we show that when the substrate network is highly connected, the action network spontaneously develops hubs with a broad distribution of out-degrees, defining a robust leadership structure that is scale-free. Furthermore, in certain, realistic parameter ranges, facilitated by information passing on the action network, agents can spontaneously generate a high degree of cooperation making the collective almost maximally efficient.

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.

PubMed

Chen, Kaifu; Chen, Zhong; Wu, Dayong; Zhang, Lili; Lin, Xueqiu; Su, Jianzhong; Rodriguez, Benjamin; Xi, Yuanxin; Xia, Zheng; Chen, Xi; Shi, Xiaobing; Wang, Qianben; Li, Wei

2015-10-01

Tumor suppressors are mostly defined by inactivating mutations in tumors, yet little is known about their epigenetic features in normal cells. Through integrative analysis of 1,134 genome-wide epigenetic profiles, mutations from >8,200 tumor-normal pairs and our experimental data from clinical samples, we discovered broad peaks for trimethylation of histone H3 at lysine 4 (H3K4me3; wider than 4 kb) as the first epigenetic signature for tumor suppressors in normal cells. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity, which together lead to exceptionally high gene expression, and is distinct from other broad epigenetic features, such as super-enhancers. Genes with broad H3K4me3 peaks conserved across normal cells may represent pan-cancer tumor suppressors, such as TP53 and PTEN, whereas genes with cell type-specific broad H3K4me3 peaks may represent cell identity genes and cell type-specific tumor suppressors. Furthermore, widespread shortening of broad H3K4me3 peaks in cancers is associated with repression of tumor suppressors. Thus, the broad H3K4me3 epigenetic signature provides mutation-independent information for the discovery and characterization of new tumor suppressors.

A chemical model for lunar non-mare rocks

NASA Technical Reports Server (NTRS)

Hubbard, N. J.; Rhodes, J. M.

1974-01-01

Nearly all rocks returned from the moon are readily divided into three broad categories on the basis of their chemical compositions: (1) mare basalts, (2) non-mare rocks of basaltic composition (KREEP, VHA), and (3) anorthositic rocks. Only mare basalts may unambiguously be considered to have original igneous textures and are widely understood to have an igneous origin. Nearly all other lunar rocks have lost their original textures during metamorphic and impact processes. It is shown that for these rocks one must work primarily with chemical data in order to recognize and define rock groups and their possible modes of origin. Non-mare rocks of basaltic composition have chemical compositions consistent with an origin by partial melting of the lunar interior. The simplest origin for rocks of anorthositic chemical composition is the crystallization and removal of ferromagnesian minerals. It is proposed that the rock groups of anorthositic and non-mare basaltic chemical composition could have been generated from a single series of original but not necessarily primitive lunar materials.

Biotechnology in Turkey: an overview.

PubMed

Ozdamar, Tunçer H

2009-07-01

The term biotechnology first appeared in the programs of the Scientific and Technological Research Council of Turkey (TUBITAK) in 1982. The State Planning Organization (SPO) in 1988 defined biotechnology and the scientific fields. Moreover, it put forward an institutional framework and suggested priority areas for research and development. Turkey has been researching and investing in biotechnology for almost four decades. This review covers the development of science and technology policy with its history, consensus and consequences, bio-industries in Turkey, and research activities in biotechnology at Turkish Universities. Details are provided by the research groups in response to a common request for information on their activities and major publications in the field. The information provided has been grouped under thematic topics within the broad theme of biotechnology, and summarized within these topics. Although many aspects of biotechnological research are being pursued in Turkey, it appears that the most common research activities of the field are in fermentation processes, environmental biotechnology, and biomedical engineering.

A chemical model for lunar non-mare rocks

NASA Technical Reports Server (NTRS)

Hubbard, N. J.; Rhodes, J. M.

1977-01-01

Nearly all rocks returned from the moon are readily divided into three broad categories on the basis of their chemical compositions: (1) mare basalts, (2) non-mare rocks of basaltic composition (KREEP, VHA), and (3) anorthositic rocks. Only mare basalts may unambiguously be considered to have original igneous textures and are widely understood to have an igneous origin. Nearly all other lunar rocks have lost their original textures during metamorphic and impact processes. For these rocks one must work primarily with chemical data in order to recognize and define rock groups and their possible modes of origin. Non-mare rocks of basaltic composition have chemical compositions consistent with an origin by partial melting of the lunar interior. The simplest origin for rocks of anorthositic chemical composition is the crystallization and removal of ferromagnesian minerals. It is proposed that the rock groups of anorthositic and non-mare basaltic chemical composition could have been generated from a single series of original, but not necessarily primitive, lunar materials.

SPICE: exploration and analysis of post-cytometric complex multivariate datasets.

PubMed

Roederer, Mario; Nozzi, Joshua L; Nason, Martha C

2011-02-01

Polychromatic flow cytometry results in complex, multivariate datasets. To date, tools for the aggregate analysis of these datasets across multiple specimens grouped by different categorical variables, such as demographic information, have not been optimized. Often, the exploration of such datasets is accomplished by visualization of patterns with pie charts or bar charts, without easy access to statistical comparisons of measurements that comprise multiple components. Here we report on algorithms and a graphical interface we developed for these purposes. In particular, we discuss thresholding necessary for accurate representation of data in pie charts, the implications for display and comparison of normalized versus unnormalized data, and the effects of averaging when samples with significant background noise are present. Finally, we define a statistic for the nonparametric comparison of complex distributions to test for difference between groups of samples based on multi-component measurements. While originally developed to support the analysis of T cell functional profiles, these techniques are amenable to a broad range of datatypes. Published 2011 Wiley-Liss, Inc.

29 CFR 801.8 - Employment relationship.

Code of Federal Regulations, 2010 CFR

2010-07-01

... broadly defines “employer” to include “any person acting directly or indirectly in the interest of an... vocational trade schools with respect to persons who may be referred to potential employers. Such entities...

TERSSE: Definition of the Total Earth Resources System for the Shuttle Era. Volume 8: User's Mission and System Requirements Data (appendix A of Volume 3)

NASA Technical Reports Server (NTRS)

1974-01-01

A computer printout is presented of the mission requirement for the TERSSE missions and their associated user tasks. The data included in the data base represents a broad-based attempt to define the amount, extent, and type of information needed for an earth resources management program in the era of the space shuttle. An effort was made to consider all aspects of remote sensing and resource management; because of its broad scope, it is not intended that the data be used without verification for in-depth studies of particular missions and/or users. The data base represents the quantitative structure necessary to define the TERSSE architecture and requirements, and to an overall integrated view of the earth resources technology requirements of the 1980's.

Broad phonetic class definition driven by phone confusions

NASA Astrophysics Data System (ADS)

Lopes, Carla; Perdigão, Fernando

2012-12-01

Intermediate representations between the speech signal and phones may be used to improve discrimination among phones that are often confused. These representations are usually found according to broad phonetic classes, which are defined by a phonetician. This article proposes an alternative data-driven method to generate these classes. Phone confusion information from the analysis of the output of a phone recognition system is used to find clusters at high risk of mutual confusion. A metric is defined to compute the distance between phones. The results, using TIMIT data, show that the proposed confusion-driven phone clustering method is an attractive alternative to the approaches based on human knowledge. A hierarchical classification structure to improve phone recognition is also proposed using a discriminative weight training method. Experiments show improvements in phone recognition on the TIMIT database compared to a baseline system.

The Sense of Incompleteness as a Motivator of Obsessive-Compulsive Symptoms: An Empirical Analysis of Concepts and Correlates

PubMed Central

Taylor, Steven; McKay, Dean; Crowe, Katherine B.; Abramowitz, Jonathan S.; Conelea, Christine A.; Calamari, John E.; Sica, Claudio

2014-01-01

Contemporary models of obsessive-compulsive disorder emphasize the importance of harm avoidance (HA) and related dysfunctional beliefs as motivators of obsessive-compulsive (OC) symptoms. Recently, there has been a resurgence of interest in Janet’s (1908) concept of incompleteness (INC) as another potentially important motivator. Contemporary investigators define INC as the sense that one’s actions, intentions, or experiences have not been properly achieved. Janet defined INC more broadly to include alexithymia, depersonalization, derealization, and impaired psychological mindedness. We conducted two studies to address four issues: (a) the clinical correlates of INC; (b) whether INC and HA are distinguishable constructs; (c) whether INC predicts OC symptoms after controlling for HA; and (d) the relative merits of broad versus narrow conceptualizations of INC. Study 1 was a meta-analysis of the clinical correlates of narrowly defined INC (16 studies, N=5,940). INC was correlated with all types of OC symptoms, and was more strongly correlated with OC symptoms than with general distress. Study 2 (N=534 nonclinical participants) showed that: (a) INC and HA were strongly correlated but factor analytically distinguishable; (b) INC statistically predicted all types of OC symptoms even after controlling for HA; and (c) narrow INC was most strongly correlated with OC symptoms whereas broad INC was most strongly correlated with general distress. Although the findings are limited by being correlational in nature, they support the hypothesis that INC, especially in its narrow form, is a motivator of OC symptoms. PMID:24491200

The role of fecundity and reproductive effort in defining life-history strategies of North American freshwater mussels.

PubMed

Haag, Wendell R

2013-08-01

Selection is expected to optimize reproductive investment resulting in characteristic trade-offs among traits such as brood size, offspring size, somatic maintenance, and lifespan; relative patterns of energy allocation to these functions are important in defining life-history strategies. Freshwater mussels are a diverse and imperiled component of aquatic ecosystems, but little is known about their life-history strategies, particularly patterns of fecundity and reproductive effort. Because mussels have an unusual life cycle in which larvae (glochidia) are obligate parasites on fishes, differences in host relationships are expected to influence patterns of reproductive output among species. I investigated fecundity and reproductive effort (RE) and their relationships to other life-history traits for a taxonomically broad cross section of North American mussel diversity. Annual fecundity of North American mussel species spans nearly four orders of magnitude, ranging from < 2000 to 10 million, but most species have considerably lower fecundity than previous generalizations, which portrayed the group as having uniformly high fecundity (e.g. > 200000). Estimates of RE also were highly variable, ranging among species from 0.06 to 25.4%. Median fecundity and RE differed among phylogenetic groups, but patterns for these two traits differed in several ways. For example, the tribe Anodontini had relatively low median fecundity but had the highest RE of any group. Within and among species, body size was a strong predictor of fecundity and explained a high percentage of variation in fecundity among species. Fecundity showed little relationship to other life-history traits including glochidial size, lifespan, brooding strategies, or host strategies. The only apparent trade-off evident among these traits was the extraordinarily high fecundity of Leptodea, Margaritifera, and Truncilla, which may come at a cost of greatly reduced glochidial size; there was no relationship between fecundity and glochidial size for the remaining 61 species in the dataset. In contrast to fecundity, RE showed evidence of a strong trade-off with lifespan, which was negatively related to RE. The raw number of glochidia produced may be determined primarily by physical and energetic constraints rather than selection for optimal output based on differences in host strategies or other traits. By integrating traits such as body size, glochidial size, and fecundity, RE appears more useful in defining mussel life-history strategies. Combined with trade-offs between other traits such as growth, lifespan, and age at maturity, differences in RE among species depict a broad continuum of divergent strategies ranging from strongly r-selected species (e.g. tribe Anodontini and some Lampsilini) to K-selected species (e.g. tribes Pleurobemini and Quadrulini; family Margaritiferidae). Future studies of reproductive effort in an environmental and life-history context will be useful for understanding the explosive radiation of this group of animals in North America and will aid in the development of effective conservation strategies. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Myiasis

PubMed Central

Francesconi, Fabio

2012-01-01

Summary: Myiasis is defined as the infestation of live vertebrates (humans and/or animals) with dipterous larvae. In mammals (including humans), dipterous larvae can feed on the host's living or dead tissue, liquid body substance, or ingested food and cause a broad range of infestations depending on the body location and the relationship of the larvae with the host. In this review, we deeply discuss myiasis as a worldwide infestation with different agents and with its broad scenario of clinical manifestations as well as diagnosis techniques and treatment. PMID:22232372

[Equity in health according to reports by the Brazilian National Health Conferences since enactment of the 1988 Federal Constitution].

PubMed

Pinheiro, Marcelo Cardoso; Westphal, Márcia Faria; Akerman, Marco

2005-01-01

Based on a literature review and taking into account a concept of equity and its application to the field of public health, this article discusses the meaning ascribed to the term "equity" and its variations in the reports by the 9th, 10th, and 11th National Health Conferences in Brazil. Qualitative methods and content analysis were used to evaluate the approach to equity in two products the Conferences intended to formulate: analysis and presentation of the country's health profile and guidelines for public health policies. Little progress in understanding the issue of equity in health was observed; the predominant discourse was vague or excessively broad. The proposals were generic and nonspecific, failing to define the target problems and social groups.

Pedagogy as influencing nursing students' essentialized understanding of culture.

PubMed

Gregory, David; Harrowing, Jean; Lee, Bonnie; Doolittle, Lisa; O'Sullivan, Patrick S

2010-01-01

In this qualitative study, we explored how students understood "culture." Participants defined culture and wrote narratives regarding specific cultural encounters. The sample comprised both nursing (n=14) and non-nursing (n=8) students to allow for comparison groups. Content analysis of the narratives revealed two broad paradigms of cultural understanding: essentialist and constructivist. Essentialist narratives comprised four themes: determinism (culture defied individual resistance); relativism (the possibility of making value judgments disappeared); Othering (culture was equated to exotica, and emphasized difference); and, reductionism (personhood was eclipsed by culture). In contrast, the constructivist narratives were characterized by influence (non-determinism), dynamism (culture was dynamic and evolutionary); and, relationship-building. The unintended negative consequences of essentialist notions of culture were revealed in the nursing students' narratives. Pedagogy is implicated in nursing students' essentialized understanding of culture.

Heart Failure in Minority Populations - Impediments to Optimal Treatment in Australian Aborigines

PubMed Central

Iyngkaran, Pupalan; Kangaharan, Nadarajan; Zimmet, Hendrik; Arstall, Margaret; Minson, Rob; Thomas, Merlin C.; Bergin, Peter; Atherton, John; MacDonald, Peter; Hare, David L.; Horowitz, John D.; Ilton, Marcus

2016-01-01

Chronic heart failure (CHF) among Aboriginal/Indigenous Australians is endemic. There are also grave concerns for outcomes once acquired. This point is compounded by a lack of prospective and objective studies to plan care. To capture the essence of the presented topic it is essential to broadly understand Indigenous health. Key words such as ‘worsening’, ‘gaps’, ‘need to do more’, ‘poorly studied’, or ‘future studies should inform’ occur frequently in contrast to CHF research for almost all other groups. This narrative styled opinion piece attempts to discuss future directions for CHF care for Indigenous Australians. We provide a synopsis of the problem, highlight the treatment gaps, and define the impediments that present hurdles in optimising CHF care for Indigenous Australians. PMID:27280307

Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

PubMed

Zhang, Jingjing; Friberg, Ida M; Kift-Morgan, Ann; Parekh, Gita; Morgan, Matt P; Liuzzi, Anna Rita; Lin, Chan-Yu; Donovan, Kieron L; Colmont, Chantal S; Morgan, Peter H; Davis, Paul; Weeks, Ian; Fraser, Donald J; Topley, Nicholas; Eberl, Matthias

2017-07-01

The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patients, unequivocal evidence that an individual's immune system distinguishes between different organisms and mounts an appropriate response is lacking. We here used a systematic approach to characterize responses to microbiologically well-defined infection in a total of 83 peritoneal dialysis patients on the day of presentation with acute peritonitis. A broad range of cellular and soluble parameters was determined in peritoneal effluents, covering the majority of local immune cells, inflammatory and regulatory cytokines and chemokines as well as tissue damage-related factors. Our analyses, utilizing machine-learning algorithms, demonstrate that different groups of bacteria induce qualitatively distinct local immune fingerprints, with specific biomarker signatures associated with Gram-negative and Gram-positive organisms, and with culture-negative episodes of unclear etiology. Even more, within the Gram-positive group, unique immune biomarker combinations identified streptococcal and non-streptococcal species including coagulase-negative Staphylococcus spp. These findings have diagnostic and prognostic implications by informing patient management and treatment choice at the point of care. Thus, our data establish the power of non-linear mathematical models to analyze complex biomedical datasets and highlight key pathways involved in pathogen-specific immune responses. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

INFORMATION-THEORETIC INEQUALITIES ON UNIMODULAR LIE GROUPS

PubMed Central

Chirikjian, Gregory S.

2010-01-01

Classical inequalities used in information theory such as those of de Bruijn, Fisher, Cramér, Rao, and Kullback carry over in a natural way from Euclidean space to unimodular Lie groups. These are groups that possess an integration measure that is simultaneously invariant under left and right shifts. All commutative groups are unimodular. And even in noncommutative cases unimodular Lie groups share many of the useful features of Euclidean space. The rotation and Euclidean motion groups, which are perhaps the most relevant Lie groups to problems in geometric mechanics, are unimodular, as are the unitary groups that play important roles in quantum computing. The extension of core information theoretic inequalities defined in the setting of Euclidean space to this broad class of Lie groups is potentially relevant to a number of problems relating to information gathering in mobile robotics, satellite attitude control, tomographic image reconstruction, biomolecular structure determination, and quantum information theory. In this paper, several definitions are extended from the Euclidean setting to that of Lie groups (including entropy and the Fisher information matrix), and inequalities analogous to those in classical information theory are derived and stated in the form of fifteen small theorems. In all such inequalities, addition of random variables is replaced with the group product, and the appropriate generalization of convolution of probability densities is employed. An example from the field of robotics demonstrates how several of these results can be applied to quantify the amount of information gained by pooling different sensory inputs. PMID:21113416

New Methodologies for Generation of Multigroup Cross Sections for Shielding Applications

NASA Astrophysics Data System (ADS)

Arzu Alpan, F.; Haghighat, Alireza

2003-06-01

Coupled neutron and gamma multigroup (broad-group) libraries used for Light Water Reactor shielding and dosimetry commonly include 47-neutron and 20-gamma groups. These libraries are derived from the 199-neutron, 42-gamma fine-group VITAMIN-B6 library. In this paper, we introduce modifications to the generation procedure of the broad-group libraries. Among these modifications, we show that the fine-group structure and collapsing technique have the largest impact. We demonstrate that a more refined fine-group library and the bi-linear adjoint weighting collapsing technique can improve the accuracy of transport calculation results.

Measuring service line competitive position. A systematic methodology for hospitals.

PubMed

Studnicki, J

1991-01-01

To mount a broad effort aimed at improving their competitive position for some service or group of services, hospitals have begun to pursue product line management techniques. A few hospitals have even reorganized completely under the product line framework. The benefits include focusing accountability for operations and results, facilitating coordination between departments and functions, stimulating market segmentation, and promoting rigorous examination of new and existing programs. As part of its strategic planning process, a suburban Baltimore hospital developed a product line management methodology with six basic steps: (1) define the service lines (which they did by grouping all existing diagnosis-related groups into 35 service lines), (2) determine the contribution of each service line to total inpatient volume, (3) determine trends in service line volumes (by comparing data over time), (4) derive a useful comparison group (competing hospitals or groups of hospitals with comparable size, scope of services, payer mix, and financial status), (5) review multiple time frames, and (6) summarize the long- and short-term performance of the hospital's service lines to focus further analysis. This type of systematic and disciplined analysis can become part of a permanent strategic intelligence program. When hospitals have such a program in place, their market research, planning, budgeting, and operations will be tied together in a true management decision support system.

The 2010 Broad Prize

ERIC Educational Resources Information Center

Education Digest: Essential Readings Condensed for Quick Review, 2011

2011-01-01

A new data analysis, based on data collected as part of The Broad Prize process, provides insights into which large urban school districts in the United States are doing the best job of educating traditionally disadvantaged groups: African-American, Hispanics, and low-income students. Since 2002, The Eli and Edythe Broad Foundation has awarded The…

Super-massive binary black holes and emission lines in active galactic nuclei

NASA Astrophysics Data System (ADS)

Popović, Luka Č.

2012-02-01

It is now agreed that mergers play an essential role in the evolution of galaxies and therefore that mergers of supermassive black holes (SMBHs) must have been common. We see the consequences of past supermassive binary black holes (SMBs) in the light profiles of so-called 'core ellipticals' and a small number of SMBs have been detected. However, the evolution of SMBs is poorly understood. Theory predicts that SMBs should spend a substantial amount of time orbiting at velocities of a few thousand kilometers per second. If the SMBs are surrounded by gas observational effects might be expected from accretion onto one or both of the SMBHs. This could result in a binary Active Galactic Nucleus (AGN) system. Like a single AGN, such a system would emit a broad band electromagnetic spectrum and broad and narrow emission lines. The broad emission spectral lines emitted from AGNs are our main probe of the geometry and physics of the broad line region (BLR) close to the SMBH. There is a group of AGNs that emit very broad and complex line profiles, showing two displaced peaks, one blueshifted and one redshifted from the systemic velocity defined by the narrow lines, or a single such peak. It has been proposed that such line shapes could indicate an SMB system. We discuss here how the presence of an SMB will affect the BLRs of AGNs and what the observational consequences might be. We review previous claims of SMBs based on broad line profiles and find that they may have non-SMB explanations as a consequence of a complex BLR structure. Because of these effects it is very hard to put limits on the number of SMBs from broad line profiles. It is still possible, however, that unusual broad line profiles in combination with other observational effects (line ratios, quasi-periodical oscillations, spectropolarimetry, etc.) could be used for SMBs detection. Some narrow lines (e.g., [O III]) in some AGNs show a double-peaked profile. Such profiles can be caused by streams in the Narrow Line Region (NLR), but may also indicate the presence of a kilo-parsec scale mergers. A few objects indicated as double-peaked narrow line emitters are confirmed as kpc-scale margers, but double-peaked narrow line profiles are mostly caused by the complex NLR geometry. We briefly discuss the expected line profile of broad Fe Kα that probably originated in the accretion disk(s) around SMBs. This line may also be very complex and indicate the complex disk geometry or/and an SMB presence. Finally we consider rare configurations where a SMB system might be gravitationally lensed by a foreground galaxy, and discuss the expected line profiles in these systems.

Thyroid disrupting chemicals: Mechanisms and mixtures

EPA Science Inventory

Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly defined, TDCs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (TH) homeostasis, or change circulating o...

Elder Abuse: Some Questions for Policymakers.

ERIC Educational Resources Information Center

Callahan, James J. Jr.

1988-01-01

Claims elder abuse is not clearly defined, affects relatively small numbers of older persons, is an under-funded area of social service and has weak political support. Recommends a broad-based service strategy for older persons. (Author/ABL)

The most important of all the organs: Darwin on the brain.

PubMed

Jacyna, Stephen

2009-12-01

This article discusses Charles Darwin's interest in topics that may broadly be defined as 'neurological' in character. Using published and manuscript materials, it examines the sources of Darwin's knowledge of neurological matters and seeks to explain why questions concerning the relation of mind and brain both in humans and other animals were relevant to his wider concerns. The paper concludes with a discussion of Darwin's impact on late 19th and early 20th century neurological thought. The 150th anniversary of the publication of the Origin of Species and the 200th of the birth of its author afford an opportunity to reflect on Charles Darwin's relationship to neurology. The first section of this article considers the part played by what might broadly be defined as 'neurological' materials in the shaping of Darwin's theory. The following section provides a brief review of the impact that Darwin's ideas were to have upon subsequent neurological thought.

Analysis of the impact of the use of broad specification fuels on combustors for commercial aircraft gas turbine engines

NASA Technical Reports Server (NTRS)

Szetela, E. J.; Lehmann, R. P.; Smith, A. L.

1979-01-01

An analytical study was conducted to assess the impact of the use of broad specification fuels with reduced hydrogen content on the design, performance, durability, emissions and operational characteristics of combustors for commercial aircraft gas turbine engines. The study was directed at defining necessary design revisions to combustors designed for use of Jet A when such are operated on ERBS (Experimental Referee Broad Specification Fuel) which has a nominal hydrogen content of 12.8 percent as opposed to 13.7 percent in current Jet A. The results indicate that improvements in combustor liner cooling, and/or materials, and methods of fuel atomization will be required if the hydrogen content of aircraft gas turbine fuel is decreased.

Automated analysis in generic groups

NASA Astrophysics Data System (ADS)

Fagerholm, Edvard

This thesis studies automated methods for analyzing hardness assumptions in generic group models, following ideas of symbolic cryptography. We define a broad class of generic and symbolic group models for different settings---symmetric or asymmetric (leveled) k-linear groups --- and prove ''computational soundness'' theorems for the symbolic models. Based on this result, we formulate a master theorem that relates the hardness of an assumption to solving problems in polynomial algebra. We systematically analyze these problems identifying different classes of assumptions and obtain decidability and undecidability results. Then, we develop automated procedures for verifying the conditions of our master theorems, and thus the validity of hardness assumptions in generic group models. The concrete outcome is an automated tool, the Generic Group Analyzer, which takes as input the statement of an assumption, and outputs either a proof of its generic hardness or shows an algebraic attack against the assumption. Structure-preserving signatures are signature schemes defined over bilinear groups in which messages, public keys and signatures are group elements, and the verification algorithm consists of evaluating ''pairing-product equations''. Recent work on structure-preserving signatures studies optimality of these schemes in terms of the number of group elements needed in the verification key and the signature, and the number of pairing-product equations in the verification algorithm. While the size of keys and signatures is crucial for many applications, another aspect of performance is the time it takes to verify a signature. The most expensive operation during verification is the computation of pairings. However, the concrete number of pairings is not captured by the number of pairing-product equations considered in earlier work. We consider the question of what is the minimal number of pairing computations needed to verify structure-preserving signatures. We build an automated tool to search for structure-preserving signatures matching a template. Through exhaustive search we conjecture lower bounds for the number of pairings required in the Type~II setting and prove our conjecture to be true. Finally, our tool exhibits examples of structure-preserving signatures matching the lower bounds, which proves tightness of our bounds, as well as improves on previously known structure-preserving signature schemes.

Supporting family carers through telephone-mediated group programs: opportunities for gerontological social workers.

PubMed

Shanley, Chris

2008-01-01

Telephone-mediated group programs are an important but under-utilized medium for reaching frail or disabled older persons' family carers who are in need of support. The primary purpose and style of group programs can range across a broad spectrum-encompassing educational, supportive and therapeutic types. Gerontological social workers are the members of the multidisciplinary care team whose training, experience and supervision makes them most suitable for facilitating this broad range of group types. Drawing on the experience of training a number of group facilitators, this article provides suggestions for social workers contemplating the use of telephone-mediated groups and highlights groupwork skills peculiar to conducting group programs via the telephone.

Supporting Family Carers Through Telephone-Mediated Group Programs: Opportunities For Gerontological Social Workers.

PubMed

Shanley, Chris

2008-01-01

Telephone-mediated group programs are an important but under-utilized medium for reaching frail or disabled older persons' family carers who are in need of support. The primary purpose and style of group programs can range across a broad spectrum–encompassing educational, supportive and therapeutic types. Gerontological social workers are the members of the multidisciplinary care team whose training, experience and supervision makes them most suitable for facilitating this broad range of group types. Drawing on the experience of training a number of group facilitators, this article provides suggestions for social workers contemplating the use of telephone-mediated groups and highlights groupwork skills peculiar to conducting group programs via the telephone.

12 CFR 621.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... accepted accounting principles means that body of conventions, rules, and procedures necessary to define accepted accounting practices at a particular time, as promulgated by the Financial Accounting Standards... profession in the United States. Generally accepted accounting principles include not only broad guidelines...

Investment in Education.

ERIC Educational Resources Information Center

Jorgenson, Dale W.; Fraumeni, Barbara W.

1989-01-01

Presents two new measures of the benefits from education, based on the incremental effect that participation in formal schooling has on human wealth, which is broadly defined. The expenditures of educational institutions are very much smaller than the benefits of education. (Author/BJV)

Making ITS/CVO happen : Pennsylvania's ITS/CVO business plan

DOT National Transportation Integrated Search

1998-12-31

This business plan will be used to coordinate the deployment of CVO technologies in Pennsylvania. It provides a 'roadmap' for Pennsylvania's ITS/CVO program by defining broad goals and objectives, as well as specific projects, milestones, responsibil...

Usability of a new disposable autoinjector platform device: results of a formative study conducted with a broad user population.

PubMed

Lange, Jakob; Richard, Philipp; Bradley, Nick

2015-01-01

This article presents a late-stage formative usability study of an autoinjector platform device. Such devices are used for the subcutaneous delivery of biopharmaceuticals, primarily for self-administration by the patient. Previous usability work on autoinjectors reported in the literature has been specific to single indications. This study was instead conducted with a broad user population, defined to represent user characteristics across a range of indications. The goals of the study were to evaluate whether users could use the devices safely and effectively, and could understand the instructions for use (IFU) as well as the accompanying training. Further objectives were to capture any usability issues and to obtain participants' subjective ratings on the IFU and training as well as the confidence and comfort in using the device. A total of 43 participants in 5 groups received training and performed simulated injections either into an injection pad or a mannequin. All participants were able to successfully use the device. The device was well appreciated by all users, with a reported degree of confidence in using the device of 98%, of user comfort of 93%, and of comprehensibility of IFU and training of 98%. These values are higher than other comparable results reported in the literature. The presence of both audible and visible feedback during injection was seen to be a significant factor contributing to injection success. The observation that the device can be safely and efficiently used by all tested user groups provides confidence that the device and IFU in their current form will pass future summative testing in specific applications.

Classifying insulin regimens--difficulties and proposal for comprehensive new definitions.

PubMed

Neu, A; Lange, K; Barrett, T; Cameron, F; Dorchy, H; Hoey, H; Jarosz-Chobot, P; Mortensen, H B; Robert, J-J; Robertson, K; de Beaufort, C

2015-09-01

Modern insulin regimens for the treatment of type 1 diabetes are highly individualized. The concept of an individually tailored medicine accounts for a broad variety of different insulin regimens applied. Despite clear recommendations for insulin management in children and adolescents with type 1 diabetes there is little distinctiveness about concepts and the nomenclature is confusing. Even among experts similar terms are used for different strategies. The aim of our review--based on the experiences of the Hvidoere Study Group (HSG)--is to propose comprehensive definitions for current insulin regimens reflecting current diabetes management in childhood and adolescence. The HSG--founded in 1994--is an international group representing 24 highly experienced pediatric diabetes centers, from Europe, Japan, North America and Australia. Different benchmarking studies of the HSG revealed a broad variety of insulin regimens applied in each center, respectively. Furthermore, the understanding of insulin regimens has been persistently different between the centers since more than 20 yr. Not even the terms 'conventional' and 'intensified therapy' were used consistently among all members. Besides the concepts 'conventional' and 'intensified', several other terms for the characterization of insulin regimens are in use: Basal Bolus Concept (BBC), multiple daily injections (MDI), and flexible insulin therapy (FIT) are most frequently used, although none of these expressions is clearly or consistently defined. The proposed new classification for insulin management will be comprehensive, simple, and catchy. Currently available terms were included. This classification may offer the opportunity to compare therapeutic strategies without the currently existing confusion on the insulin regimen. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Understanding the Personality and Behavioral Mechanisms Defining Hypersexuality in Men Who Have Sex with Men

PubMed Central

Miner, Michael H.; Romine, Rebecca Swinburne; Raymond, Nancy; Janssen, Erick; MacDonald, Angus; Coleman, Eli

2016-01-01

Objective The purpose of this study was to investigate personality factors and behavioral mechanisms that are relevant to hypersexuality in men who have sex with men. Method A sample of 242 men who have sex with men were recruited from various sites in a moderate size mid-western city. Participants were assigned to hypersexuality or control group using a SCID-type interview. Self-report inventories were administered that measured the broad band personality constructs of positive emotionality, negative emotionality and constraint, and more narrow constructs related to sexual behavioral control, behavioral activation, behavioral inhibition, sexual excitation, sexual inhibition, impulsivity, ADHD, and sexual behavior. Hierarchical logistic regression was used to determine the relationship between these personality and behavioral variables and group membership. Results A hierarchical logistic regression, controlling for age, revealed a significant positive relationship between hypersexuality and negative emotionality and a negative relationship with constraint. None of the behavioral mechanism variables entered this equation. However, a hierarchical multiple regression predicting sexual behavioral control indicated that lack of such control was positively related to sexual excitation and sexual inhibition due to the threat of performance failure and negatively related to sexual inhibition due to the threat of performance consequences and general behavioral inhibition Conclusions Hypersexuality was found to be related to two broad personality factors that are characterized by emotional reactivity, risk-taking, and impulsivity. The associated lack of sexual behavior control is influenced by both sexual excitatory and inhibitory mechanisms, but not general behavioral activation and inhibitory mechanisms. PMID:27486137

Characterization of novel Staphylococcus aureus lytic phage and defining their combinatorial virulence using the OmniLog® system

PubMed Central

Estrella, Luis A.; Quinones, Javier; Henry, Matthew; Hannah, Ryan M.; Pope, Robert K.; Hamilton, Theron; Teneza-mora, Nimfa; Hall, Eric; Biswajit, Biswas

2016-01-01

ABSTRACT Skin and soft tissue infections (SSTI) caused by methicillin resistant Staphylococcus aureus (MRSA) are difficult to treat. Bacteriophage (phage) represent a potential alternate treatment for antibiotic resistant bacterial infections. In this study, 7 novel phage with broad lytic activity for S. aureus were isolated and identified. Screening of a diverse collection of 170 clinical isolates by efficiency of plating (EOP) assays shows that the novel phage are virulent and effectively prevent growth of 70–91% of MRSA and methicillin sensitive S. aureus (MSSA) isolates. Phage K, which was previously identified as having lytic activity on S. aureus was tested on the S. aureus collection and shown to prevent growth of 82% of the isolates. These novel phage group were examined by electron microscopy, the results of which indicate that the phage belong to the Myoviridae family of viruses. The novel phage group requires β-N-acetyl glucosamine (GlcNac) moieties on cell wall teichoic acids for infection. The phage were distinct from, but closely related to, phage K as characterized by restriction endonuclease analysis. Furthermore, growth rate analysis via OmniLog® microplate assay indicates that a combination of phage K, with phage SA0420ᶲ1, SA0456ᶲ1 or SA0482ᶲ1 have a synergistic phage-mediated lytic effect on MRSA and suppress formation of phage resistance. These results indicate that a broad spectrum lytic phage mixture can suppress the emergence of resistant bacterial populations and hence have great potential for combating S. aureus wound infections. PMID:27738555

TSA - A Two Scale Approximation for Wind-Generated Ocean Surface Waves

DTIC Science & Technology

2012-09-30

broad-scale version of TSA, or ‘ dTSA ’. In this manner dTSA is able to respond to changing wind situations. Results were shown to compare well with ‘exact...We also implemented the revised version of TSA, denoted ‘ dTSA ’, in WW3 for tests with a storm case, hurricane Juan, which made landfall as a...manner in which the broad-scale of TSA was defined, developing ‘ dTSA ’ as described above, so that in complicated rapidly changing wave spectra cases, a

Node, Node-Link, and Node-Link-Group Diagrams: An Evaluation.

PubMed

Saket, Bahador; Simonetto, Paolo; Kobourov, Stephen; Börner, Katy

2014-12-01

Effectively showing the relationships between objects in a dataset is one of the main tasks in information visualization. Typically there is a well-defined notion of distance between pairs of objects, and traditional approaches such as principal component analysis or multi-dimensional scaling are used to place the objects as points in 2D space, so that similar objects are close to each other. In another typical setting, the dataset is visualized as a network graph, where related nodes are connected by links. More recently, datasets are also visualized as maps, where in addition to nodes and links, there is an explicit representation of groups and clusters. We consider these three Techniques, characterized by a progressive increase of the amount of encoded information: node diagrams, node-link diagrams and node-link-group diagrams. We assess these three types of diagrams with a controlled experiment that covers nine different tasks falling broadly in three categories: node-based tasks, network-based tasks and group-based tasks. Our findings indicate that adding links, or links and group representations, does not negatively impact performance (time and accuracy) of node-based tasks. Similarly, adding group representations does not negatively impact the performance of network-based tasks. Node-link-group diagrams outperform the others on group-based tasks. These conclusions contradict results in other studies, in similar but subtly different settings. Taken together, however, such results can have significant implications for the design of standard and domain snecific visualizations tools.

Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories.

PubMed

Strauss, Gregory P; Vertinski, Mary; Vogel, Sally J; Ringdahl, Erik N; Allen, Daniel N

2016-02-01

Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with schizophrenia (n=50), and healthy controls (n=27). Participants completed neuropsychological testing and a clinical interview designed to assess negative, positive, disorganized, mood, and general psychiatric symptoms. Results indicated differences among the 3 groups in the severity of all BNSS items, with SZ and BD scoring higher than CN; however, SZ and BD only differed on blunted affect and alogia items, not anhedonia, avolition, or asociality. BD patients with a history of psychosis did not differ from those without a history of psychosis on negative symptom severity. The BNSS had excellent internal consistency in SZ, BD, and CN groups. Good convergent and discriminant validity was apparent in SZ and BD groups, as indicated by relationships between the BNSS and other clinical rating scales. These findings support the validity of the BNSS in broadly defined serious mental illness populations. Copyright © 2015 Elsevier B.V. All rights reserved.

Virtual laboratories: new opportunities for collaborative water science

NASA Astrophysics Data System (ADS)

Ceola, Serena; Arheimer, Berit; Bloeschl, Guenter; Baratti, Emanuele; Capell, Rene; Castellarin, Attilio; Freer, Jim; Han, Dawei; Hrachowitz, Markus; Hundecha, Yeshewatesfa; Hutton, Christopher; Lindström, Goran; Montanari, Alberto; Nijzink, Remko; Parajka, Juraj; Toth, Elena; Viglione, Alberto; Wagener, Thorsten

2015-04-01

Reproducibility and repeatability of experiments are the fundamental prerequisites that allow researchers to validate results and share hydrological knowledge, experience and expertise in the light of global water management problems. Virtual laboratories offer new opportunities to enable these prerequisites since they allow experimenters to share data, tools and pre-defined experimental procedures (i.e. protocols). Here we present the outcomes of a first collaborative numerical experiment undertaken by five different international research groups in a virtual laboratory to address the key issues of reproducibility and repeatability. Moving from the definition of accurate and detailed experimental protocols, a rainfall-runoff model was independently applied to 15 European catchments by the research groups and model results were collectively examined through a web-based discussion. We found that a detailed modelling protocol was crucial to ensure the comparability and reproducibility of the proposed experiment across groups. Our results suggest that sharing comprehensive and precise protocols and running the experiments within a controlled environment (e.g. virtual laboratory) is as fundamental as sharing data and tools for ensuring experiment repeatability and reproducibility across the broad scientific community and thus advancing hydrology in a more coherent way.

[Combined effects of interferon γ and γ ray irradiation on A549 cells in vitro].

PubMed

Xia, Hui; Zhang, Yi-ming; Yu, Chang-hai; Zhang, Wen; Zhang, Bao-shi; Fang, Fang

2012-02-07

To define the role of interferon-γ on radiotherapy of lung cancer and explore a new way to clinical treatment. A549 cells were exposed to γ ray with or without IFN-γ co-treatment. MTT assay was performed to evaluate cell viability. Western blot was used to observe the expression of P53 protein. The results showed that co-treatment of IFN-γ decreased the cell viability significantly compared with the γ ray irradiation group (71.4% ± 2.1% vs 44.1% ± 3.1%, n = 7, P < 0.01). In addition, the expression of P53 protein also increased significantly after co-treatment (P < 0.01); Furthermore, the cell cycle was changed obviously in co-treatment group compared with γ ray irradiation group, S phase increased (12.9% vs 20.9%, n = 5, P < 0.05) and also blocked the G2/M phase (28.8% vs 38.9%, n = 5, P < 0.05). The results suggested that γ ray irradiation combined with IFN-γ can increase the efficiency of radiotherapy on A549 cells and there is much broad prospect in the clinical treatment of lung cancer.

The hormesis database: the occurrence of hormetic dose responses in the toxicological literature.

PubMed

Calabrese, Edward J; Blain, Robyn B

2011-10-01

In 2005 we published an assessment of dose responses that satisfied a priori evaluative criteria for inclusion within the relational retrieval hormesis database (Calabrese and Blain, 2005). The database included information on study characteristics (e.g., biological model, gender, age and other relevant aspects, number of doses, dose distribution/range, quantitative features of the dose response, temporal features/repeat measures, and physical/chemical properties of the agents). The 2005 article covered information for about 5000 dose responses; the present article has been expanded to cover approximately 9000 dose responses. This assessment extends and strengthens the conclusion of the 2005 paper that the hormesis concept is broadly generalizable, being independent of biological model, endpoint measured and chemical class/physical agent. It also confirmed the definable quantitative features of hormetic dose responses in which the strong majority of dose responses display maximum stimulation less than twice that of the control group and a stimulatory width that is within approximately 10-20-fold of the estimated toxicological or pharmacological threshold. The remarkable consistency of the quantitative features of the hormetic dose response suggests that hormesis may provide an estimate of biological plasticity that is broadly generalized across plant, microbial and animal (invertebrate and vertebrate) models. Copyright © 2011 Elsevier Inc. All rights reserved.

IUE observations of symbiotic stars

NASA Technical Reports Server (NTRS)

Sahade, J.; Brandi, E.

1981-01-01

The IUE observations suggest that the symbiotic stars can be placed in two broad groups. One of the groups is characterized by strong, narrow emissions arising from a wide range of excitation energies, while the other one typically shows a strong continuum with absorption lines and very few or no emissions at all. Both broad groups appear to suggest that these are binary systems and that they probably differ in the characteristics and extent of the chromosphere-corona formation that is present in the system.

Reviewing social media use by clinicians.

PubMed

von Muhlen, Marcio; Ohno-Machado, Lucila

2012-01-01

Adoption studies of social media use by clinicians were systematically reviewed, up to July 26th, 2011, to determine the extent of adoption and highlight trends in institutional responses. This search led to 370 articles, of which 50 were selected for review, including 15 adoption surveys. The definition of social media is evolving rapidly; the authors define it broadly to include social networks and group-curated reference sites such as Wikipedia. Facebook accounts are very common among health science students (64-96%) and less so for professional clinicians (13-47%). Adoption rates have increased sharply in the past 4 years. Wikipedia is widely used as a reference tool. Attempts at incorporating social media into clinical training have met with mixed success. Posting of unprofessional content and breaches of patient confidentiality, especially by students, are not uncommon and have prompted calls for social media guidelines.

Bibliotherapy: a critique of the literature.

PubMed

Favazza, A R

1966-04-01

Most of the literature on bibliotherapy has been nonscientific, because of the too broad use of the term "bibliotherapy." The author proposes, for the sake of clarification in the literature, that "bibliotherapy" be defined as a program of selected activity involving reading materials which is planned, conducted, and controlled under the guidance of a physician as treatment for psychiatric patients and which uses, if needed, the assistance of a trained librarian. Bibliotherapy, then, falls into three categories: books prescribed for a patient, books selected by a patient, and group discussion of books. Bibliotherapy may be helpful by facilitating abreaction, projection, narcissistic gratification, verbalization, constructive thinking between interviews, and reinforcement of social and cultural patterns. Bibliotherapy is probably indicated in self-motivated neurotic patients who ask for helpful reading materials. Bibliotherapy offers no panacea, but with proper scientific study may help many patients.

Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method

PubMed Central

2014-01-01

Background Recent efforts in HIV-1 vaccine design have focused on immunogens that evoke potent neutralizing antibody responses to a broad spectrum of viruses circulating worldwide. However, the development of effective vaccines will depend on the identification and characterization of the neutralizing antibodies and their epitopes. We developed bioinformatics methods to predict epitope networks and antigenic determinants using structural information, as well as corresponding genotypes and phenotypes generated by a highly sensitive and reproducible neutralization assay. 282 clonal envelope sequences from a multiclade panel of HIV-1 viruses were tested in viral neutralization assays with an array of broadly neutralizing monoclonal antibodies (mAbs: b12, PG9,16, PGT121 - 128, PGT130 - 131, PGT135 - 137, PGT141 - 145, and PGV04). We correlated IC50 titers with the envelope sequences, and used this information to predict antibody epitope networks. Structural patches were defined as amino acid groups based on solvent-accessibility, radius, atomic depth, and interaction networks within 3D envelope models. We applied a boosted algorithm consisting of multiple machine-learning and statistical models to evaluate these patches as possible antibody epitope regions, evidenced by strong correlations with the neutralization response for each antibody. Results We identified patch clusters with significant correlation to IC50 titers as sites that impact neutralization sensitivity and therefore are potentially part of the antibody binding sites. Predicted epitope networks were mostly located within the variable loops of the envelope glycoprotein (gp120), particularly in V1/V2. Site-directed mutagenesis experiments involving residues identified as epitope networks across multiple mAbs confirmed association of these residues with loss or gain of neutralization sensitivity. Conclusions Computational methods were implemented to rapidly survey protein structures and predict epitope networks associated with response to individual monoclonal antibodies, which resulted in the identification and deeper understanding of immunological hotspots targeted by broadly neutralizing HIV-1 antibodies. PMID:24646213

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement.

PubMed

Sachdev, Perminder; Kalaria, Raj; O'Brien, John; Skoog, Ingmar; Alladi, Suvarna; Black, Sandra E; Blacker, Deborah; Blazer, Dan G; Chen, Christopher; Chui, Helena; Ganguli, Mary; Jellinger, Kurt; Jeste, Dilip V; Pasquier, Florence; Paulsen, Jane; Prins, Niels; Rockwood, Kenneth; Roman, Gustavo; Scheltens, Philip

2014-01-01

Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical reexamination. Participants at a special symposium of the International Society for Vascular Behavioral and Cognitive Disorders (VASCOG) in 2009 critiqued the current criteria. They drafted a proposal for a new set of criteria, later reviewed through multiple drafts by the group, including additional experts and the members of the Neurocognitive Disorders Work Group of the fifth revision of Diagnostic and Statistical Manual (DSM-5) Task Force. Cognitive disorders of vascular etiology are a heterogeneous group of disorders with diverse pathologies and clinical manifestations, discussed broadly under the rubric of vascular cognitive disorders (VCD). The continuum of vascular cognitive impairment is recognized by the categories of Mild Vascular Cognitive Disorder, and Vascular Dementia or Major Vascular Cognitive Disorder. Diagnostic thresholds are defined. Clinical and neuroimaging criteria are proposed for establishing vascular etiology. Subtypes of VCD are described, and the frequent cooccurrence of Alzheimer disease pathology emphasized. The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathologic validation studies. These criteria can be harmonized with the DSM-5 criteria such that an international consensus on the criteria for VCD may be achieved.

Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia.

PubMed

Sun, Lianli; Ruppert, Martin; Sheludko, Yuri; Warzecha, Heribert; Zhao, Yu; Stöckigt, Joachim

2008-07-01

Perakine reductase (PR) catalyzes an NADPH-dependent step in a side-branch of the 10-step biosynthetic pathway of the alkaloid ajmaline. The enzyme was cloned by a "reverse-genetic" approach from cell suspension cultures of the plant Rauvolfia serpentina (Apocynaceae) and functionally expressed in Escherichia coli as the N-terminal His(6)-tagged protein. PR displays a broad substrate acceptance, converting 16 out of 28 tested compounds with reducible carbonyl function which belong to three substrate groups: benzaldehyde, cinnamic aldehyde derivatives and monoterpenoid indole alkaloids. The enzyme has an extraordinary selectivity in the group of alkaloids. Sequence alignments define PR as a new member of the aldo-keto reductase (AKR) super family, exhibiting the conserved catalytic tetrad Asp52, Tyr57, Lys84, His126. Site-directed mutagenesis of each of these functional residues to an alanine residue results in >97.8% loss of enzyme activity, in compounds of each substrate group. PR represents the first example of the large AKR-family which is involved in the biosynthesis of plant monoterpenoid indole alkaloids. In addition to a new esterase, PR significantly extends the Rauvolfia alkaloid network to the novel group of peraksine alkaloids.

Projected Standard on neutron skyshine. [Skyshine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westfall, R.M.; Williams, D.S.

1987-07-01

Current interest in neutron skyshine arises from the application of dry fuel handling and storage techniques at reactor sites, at the proposed monitored retrievable storage facility and at other facilities being considered as part of the civilian radioactive waste management programs. The chairman of Standards Subcommittee ANS-6, Radiation Protection and Shielding, has requested that a work group be formed to characterize the neutron skyshine problem and, if necessary, prepare a draft Standard. The work group is comprised of representatives of storage cask vendors, architect engineering firms, nuclear utilities, the academic community and staff members of national laboratories and government agencies.more » The purpose of this presentation summary is to describe the activities of the work group and the scope and contents of the projected Standard, ANS-6.6.2, ''Calculation and Measurement of Direct and Scattered Neutron Radiation from Nuclear Power Operations.'' The specific source under consideration by the work group is an array of dry fuel casks located at a reactor site. However, it is recognized that the scope of the standard should be broad enough to encompass other neutron sources. The Standard will define appropriate methodology for properly characterizing the neutron dose due to skyshine. This dose characterization is necessary, for example, in demonstrating compliance with pertinent regulatory criteria.« less

Biogeochemical Cycles in Degraded Lands

NASA Technical Reports Server (NTRS)

Davidson, Eric A.; Vieira, Ima Celia G.; ReisdeCarvalho, Claudio Jose; DeanedeAbreuSa, Tatiana; deSouzaMoutinho, Paulo R.; Figueiredo, Ricardo O.; Stone, Thomas A.

2004-01-01

The objectives of this project were to define and describe the types of landscapes that fall under the broad category of "degraded lands" and to study biogeochemical cycles across this range of degradation found in secondary forests. We define degraded land as that which has lost part of its capacity of renovation of a productive ecosystem, either in the context of agroecosystems or as native communities of vegetation. This definition of degradation permits evaluation of biogeochemical constraints to future land uses.

Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles

DOE PAGES

Sun, Jing; Jiang, Xi; Lund, Reidar; ...

2016-03-28

The folding and assembly of sequence-defined polymers into precisely ordered nanostructures promises a class of well-defined biomimetic architectures with specific function. Amphiphilic diblock copolymers are known to self-assemble in water to form a variety of nanostructured morphologies including spheres, disks, cylinders, and vesicles. In all of these cases, the predominant driving force for assembly is the formation of a hydrophobic core that excludes water, whereas the hydrophilic blocks are solvated and extend into the aqueous phase. However, such polymer systems typically have broad molar mass distributions and lack the purity and sequence-defined structure often associated with biologically derived polymers. Here,more » we demonstrate that purified, monodisperse amphiphilic diblock copolypeptoids, with chemically distinct domains that are congruent in size and shape, can behave like molecular tile units that spontaneously assemble into hollow, crystalline nanotubes in water. The nanotubes consist of stacked, porous crystalline rings, and are held together primarily by side-chain van der Waals interactions. The peptoid nanotubes form without a central hydrophobic core, chirality, a hydrogen bond network, and electrostatic or π-π interactions. These results demonstrate the remarkable structure-directing influence of n-alkane and ethyleneoxy side chains in polymer self-assembly. More broadly, this work suggests that flexible, low-molecular-weight sequence-defined polymers can serve as molecular tile units that can assemble into precision supramolecular architectures.« less

Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Jing; Jiang, Xi; Lund, Reidar

The folding and assembly of sequence-defined polymers into precisely ordered nanostructures promises a class of well-defined biomimetic architectures with specific function. Amphiphilic diblock copolymers are known to self-assemble in water to form a variety of nanostructured morphologies including spheres, disks, cylinders, and vesicles. In all of these cases, the predominant driving force for assembly is the formation of a hydrophobic core that excludes water, whereas the hydrophilic blocks are solvated and extend into the aqueous phase. However, such polymer systems typically have broad molar mass distributions and lack the purity and sequence-defined structure often associated with biologically derived polymers. Here,more » we demonstrate that purified, monodisperse amphiphilic diblock copolypeptoids, with chemically distinct domains that are congruent in size and shape, can behave like molecular tile units that spontaneously assemble into hollow, crystalline nanotubes in water. The nanotubes consist of stacked, porous crystalline rings, and are held together primarily by side-chain van der Waals interactions. The peptoid nanotubes form without a central hydrophobic core, chirality, a hydrogen bond network, and electrostatic or π-π interactions. These results demonstrate the remarkable structure-directing influence of n-alkane and ethyleneoxy side chains in polymer self-assembly. More broadly, this work suggests that flexible, low-molecular-weight sequence-defined polymers can serve as molecular tile units that can assemble into precision supramolecular architectures.« less

Productivity and accessibility : bridging project specific and macroeconomic analyses of transportation investments

DOT National Transportation Integrated Search

1998-10-01

Many studies of the local economic impacts of individual highway projects rely on overly narrow measures of economic benefits. Another type of research, focusing on economic productivity, defines benefits more broadly but is also limited by geographi...

Forensic Applications of LIBS

NASA Astrophysics Data System (ADS)

Hark, Richard R.; East, Lucille J.

Forensic science is broadly defined as the application of science to matters of the law. Practitioners typically use multidisciplinary scientific techniques for the analysis of physical evidence in an attempt to establish or exclude an association between a suspect and the scene of a crime.

Technological Strategies and National Purpose

ERIC Educational Resources Information Center

Gilpin, Robert

1970-01-01

Discusses the international and domestic implications of technological growth. Defines three basic national strategies: a broad front approach, scientific and technological specialization and importation. Analyzes the strategies followed by form countries - France, the United States, Sweden, and Japan- to illustrate the alternatives and the…

0-6763 : accounting for electric vehicles in air quality conformity.

DOT National Transportation Integrated Search

2014-08-01

Electric vehicles (EVs) are broadly defined as : vehicles that obtain at least a part of the energy : required for their propulsion from electricity. This : research focused on the three main types of EVs: : Hybrid electric vehicles. : Plug-i...

THYROID HORMONE DISRUPTION: FROM KINETICS TO DYNAMICS.

EPA Science Inventory

A wide range of chemicals with diverse structures act as thyroid disrupting chemicals (TDCs). Broadly defined, TDCs are chemicals that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormones (THs), or change circulating or t...

Production and Testing of the VITAMIN-B7 Fine-Group and BUGLE-B7 Broad-Group Coupled Neutron/Gamma Cross-Section Libraries Derived from ENDF/B-VII.0 Nuclear Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Risner, J. M.; Wiarda, D.; Dunn, M. E.

2011-09-30

New coupled neutron-gamma cross-section libraries have been developed for use in light water reactor (LWR) shielding applications, including pressure vessel dosimetry calculations. The libraries, which were generated using Evaluated Nuclear Data File/B Version VII Release 0 (ENDF/B-VII.0), use the same fine-group and broad-group energy structures as the VITAMIN-B6 and BUGLE-96 libraries. The processing methodology used to generate both libraries is based on the methods used to develop VITAMIN-B6 and BUGLE-96 and is consistent with ANSI/ANS 6.1.2. The ENDF data were first processed into the fine-group pseudo-problem-independent VITAMIN-B7 library and then collapsed into the broad-group BUGLE-B7 library. The VITAMIN-B7 library containsmore » data for 391 nuclides. This represents a significant increase compared to the VITAMIN-B6 library, which contained data for 120 nuclides. The BUGLE-B7 library contains data for the same nuclides as BUGLE-96, and maintains the same numeric IDs for those nuclides. The broad-group data includes nuclides which are infinitely dilute and group collapsed using a concrete weighting spectrum, as well as nuclides which are self-shielded and group collapsed using weighting spectra representative of important regions of LWRs. The verification and validation of the new libraries includes a set of critical benchmark experiments, a set of regression tests that are used to evaluate multigroup crosssection libraries in the SCALE code system, and three pressure vessel dosimetry benchmarks. Results of these tests confirm that the new libraries are appropriate for use in LWR shielding analyses and meet the requirements of Regulatory Guide 1.190.« less

Towards short wavelengths FELs workshop

NASA Astrophysics Data System (ADS)

Ben-Zvi, I.; Winick, H.

1993-11-01

This workshop was caged because of the growing perception in the FEL source community that recent advances have made it possible to extend FEL operation to wavelengths about two orders of magnitude shorter than the 240 nm that has been achieved to date. In addition short wavelength FEL's offer the possibilities of extremely high peak power (several gigawatts) and very short pulses (of the order of 100 fs). Several groups in the USA are developing plans for such short wavelength FEL facilities. However, reviewers of these plans have pointed out that it would be highly desirable to first carry out proof-of-principle experiments at longer wavelengths to increase confidence that the shorter wavelength devices will indeed perform as calculated. The need for such experiments has now been broadly accepted by the FEL community. Such experiments were the main focus of this workshop as described in the following objectives distributed to attendees: (1) Define measurements needed to gain confidence that short wavelength FEL's will perform as calculated. (2) List possible hardware that could be used to carry out these measurements in the near term. (3) Define a prioritized FEL physics experimental program and suggested timetable. (4) Form collaborative teams to carry out this program.

Politics of heat: the energy movement in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seelman, K.D.

This dissertation explores the claim that the energy problem involves a basic conflict of values between representatives of economic interests and of the public. Economic interests define the energy problems in narrow economic and technological terms, while public interests define the problem in broad societal and environmental terms. Ideological and policy positions have polarized around the following transientific problems: equity for present and future generations; the level of risk a society should take; tradeoff between laissez faire freedom and freedom and human rights to health, safety and environmental integrity, and, finally, who should decide, citizen or expert. The study ismore » based, in large part, on original materials - correspondence, interviews, reports and questionnaires - from a 4-year study on energy and values conducted by the National Council of Churches in which the author was a participant observer. The study process involved major US institutions - industry, government, labor, university, religion, and related spokespersons in the public-interest community. Findings indicate that both sides, frustrated by government bureaucracy, have designed alternative structures and techniques to resolve conflicts and expedite their goals, e.g., flexible ad hoc groups and mediation.« less

Sustainability considerations for health research and analytic data infrastructures.

PubMed

Wilcox, Adam; Randhawa, Gurvaneet; Embi, Peter; Cao, Hui; Kuperman, Gilad J

2014-01-01

The United States has made recent large investments in creating data infrastructures to support the important goals of patient-centered outcomes research (PCOR) and comparative effectiveness research (CER), with still more investment planned. These initial investments, while critical to the creation of the infrastructures, are not expected to sustain them much beyond the initial development. To provide the maximum benefit, the infrastructures need to be sustained through innovative financing models while providing value to PCOR and CER researchers. Based on our experience with creating flexible sustainability strategies (i.e., strategies that are adaptive to the different characteristics and opportunities of a resource or infrastructure), we define specific factors that are important considerations in developing a sustainability strategy. These factors include assets, expansion, complexity, and stakeholders. Each factor is described, with examples of how it is applied. These factors are dimensions of variation in different resources, to which a sustainability strategy should adapt. We also identify specific important considerations for maintaining an infrastructure, so that the long-term intended benefits can be realized. These observations are presented as lessons learned, to be applied to other sustainability efforts. We define the lessons learned, relating them to the defined sustainability factors as interactions between factors. Using perspectives and experiences from a diverse group of experts, we define broad characteristics of sustainability strategies and important observations, which can vary for different projects. Other descriptions of adaptive, flexible, and successful models of collaboration between stakeholders and data infrastructures can expand this framework by identifying other factors for sustainability, and give more concrete directions on how sustainability can be best achieved.

7 CFR 29.2436 - Wrappers (A Group).

Code of Federal Regulations, 2014 CFR

2014-01-01

..., firm, rich in oil, elastic, strong, bright finish, deep color intensity, broad, 95 percent uniform, and..., deep color intensity, broad, 95 percent uniform, and 5 percent injury tolerance. A2D Fine Dark-brown...

7 CFR 29.2436 - Wrappers (A Group).

Code of Federal Regulations, 2010 CFR

2010-01-01

..., firm, rich in oil, elastic, strong, bright finish, deep color intensity, broad, 95 percent uniform, and..., deep color intensity, broad, 95 percent uniform, and 5 percent injury tolerance. A2D Fine Dark-brown...

7 CFR 29.2436 - Wrappers (A Group).

Code of Federal Regulations, 2012 CFR

2012-01-01

..., firm, rich in oil, elastic, strong, bright finish, deep color intensity, broad, 95 percent uniform, and..., deep color intensity, broad, 95 percent uniform, and 5 percent injury tolerance. A2D Fine Dark-brown...

7 CFR 29.2436 - Wrappers (A Group).

Code of Federal Regulations, 2011 CFR

2011-01-01

..., firm, rich in oil, elastic, strong, bright finish, deep color intensity, broad, 95 percent uniform, and..., deep color intensity, broad, 95 percent uniform, and 5 percent injury tolerance. A2D Fine Dark-brown...

7 CFR 29.2436 - Wrappers (A Group).

Code of Federal Regulations, 2013 CFR

2013-01-01

..., firm, rich in oil, elastic, strong, bright finish, deep color intensity, broad, 95 percent uniform, and..., deep color intensity, broad, 95 percent uniform, and 5 percent injury tolerance. A2D Fine Dark-brown...

Lessons from the Canadian national health information technology plan for the United States: opinions of key Canadian experts.

PubMed

Zimlichman, Eyal; Rozenblum, Ronen; Salzberg, Claudia A; Jang, Yeona; Tamblyn, Melissa; Tamblyn, Robyn; Bates, David W

2012-01-01

To summarize the Canadian health information technology (HIT) policy experience and impart lessons learned to the US as it determines its policy in this area. Qualitative analysis of interviews with identified key stakeholders followed by an electronic survey. We conducted semi-structured interviews with 29 key Canadian HIT policy and opinion leaders and used a grounded theory approach to analyze the results. The informant sample was chosen to provide views from different stakeholder groups including national representatives and regional representatives from three Canadian provinces. Canadian informants believed that much of the current US direction is positive, especially regarding incentives and meaningful use, but that there are key opportunities for the US to emphasize direct engagement with providers, define a clear business case for them, sponsor large scale evaluations to assess HIT impact in a broad array of settings, determine standards but also enable access to resources needed for mid-course corrections of standards when issues are identified, and, finally, leverage implementation of digital imaging systems. Not all stakeholder groups were included, such as providers or patients. In addition, as in all qualitative research, a selection bias could be present due to the relatively small sample size. Based on Canadian experience with HIT policy, stakeholders identified as lessons for the US the need to increase direct engagement with providers and the importance of defining the business case for HIT, which can be achieved through large scale evaluations, and of recognizing and leveraging successes as they emerge.

Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

PubMed

Tylka, Tracy L; Iannantuono, Amy C

2016-06-01

Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves. Copyright © 2016 Elsevier Ltd. All rights reserved.

THYROID DISRUPTING CHEMICALS: CHALLENGES IN ASSESSING NEUROTOXIC RISK FROM ENVIRONMENTAL MIXTURES.

EPA Science Inventory

Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly defined, TDCs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (TH) homeostasis, or change circulating o...

Situating Preparedness Education within Public Pedagogy

ERIC Educational Resources Information Center

Kitagawa, Kaori

2017-01-01

Both "disaster preparedness" and "public pedagogy" have been broadly defined and diversely utilised. Preparedness has been dealt with in disciplines such as civil engineering, the sociology of disasters, public health and psychology, rather than education. Recently, inquiries into the learning and teaching of preparedness have…

Identification of Mycobacterium avium subsp. hominissuis Isolated From Drinking Water

EPA Science Inventory

Mycobacterium avium (MA) is divided into four subspecies based primarily on host-range and consists of MA subsp. avium (birds), MA subsp. silvaticum (wood pigeons), MA subsp. paratuberculosis (broad, poorly-defined host range), and the recently described MA subsp. hominissuis (hu...

48 CFR 1352.209-71 - Limitation of future contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... towards solution of broadly defined problems. This may encompass research, evaluating technical feasibility, proof of design and test, or engineering of programs not yet approved for acquisition or operation. (iii) “Proprietary Information” means all information designated as proprietary in accordance...

48 CFR 1352.209-71 - Limitation of future contracting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... towards solution of broadly defined problems. This may encompass research, evaluating technical feasibility, proof of design and test, or engineering of programs not yet approved for acquisition or operation. (iii) “Proprietary Information” means all information designated as proprietary in accordance...

Uplift and Subsidence Associated with the Great Aceh-Andaman Earthquake of 2004

NASA Image and Video Library

2006-03-01

The magnitude 9.2 Indian Ocean earthquake of December 26, 2004, produced broad regions of uplift and subsidence. In order to define the lateral extent and the downdip limit of rupture. This image is from NASA Terra spacecraft.

A Theory of Categorical Terrorism

ERIC Educational Resources Information Center

Goodwin, Jeff

2006-01-01

When revolutionaries or insurgents, broadly defined, indiscriminately attack civilians, they generally attack "complicitous civilians," i.e., those categories of noncombatants which the revolutionaries see as benefiting from, supporting and/or having a substantial capacity to influence the states that the revolutionaries are attempting to displace…

Characterization of premorbid functioning during childhood in patients with deficit vs. non-deficit schizophrenia and in their healthy siblings.

PubMed

Bucci, Paola; Mucci, Armida; Piegari, Giuseppe; Nobile, Maria; Pini, Stefano; Rossi, Alessandro; Vita, Antonio; Galderisi, Silvana; Maj, Mario

2016-07-01

Impaired premorbid adjustment has been reported in patients with schizophrenia, generally in association with unfavorable aspects of the illness (e.g., poor outcome and severe negative symptoms). Several studies attempted to define the domains of premorbid dysfunction associated with negative symptoms and poor outcome; however, most of them assessed broadly defined negative symptoms. The present study was aimed to characterize premorbid functioning in a group of patients with deficit schizophrenia (DS), characterized by the presence of at least two primary and persistent negative symptoms (PPNS), and one of patients with a diagnosis of schizophrenia who did not meet criteria for DS (NDS). The presence of emotional/behavioral problems during childhood was investigated using the Childhood Behavior Checklist (CBCL) in both patient groups and in their respective healthy siblings. The Premorbid Adjustment Scale (PAS) was also used to assess premorbid functioning during childhood in the two patient groups. PPNS were also treated as a continuous variable and correlated with the indices of premorbid functioning regardless the DS/NDS categorization. DS patients, as compared to NDS, showed higher scores on the CBCL subscale "Withdrawn". Both DS and NDS patients showed, as compared to their healthy siblings, a greater impairment on almost all CBCL subscales. PAS findings revealed that DS patients had poorer premorbid adjustment than NDS. No significant correlation between premorbid functioning and PPNS was observed. These findings support the hypothesis that DS has a different developmental trajectory with respect to NDS, and that premorbid adjustment is one of the essential aspects of its characterization. Copyright © 2016 Elsevier B.V. All rights reserved.

How to study improvement interventions: a brief overview of possible study types.

PubMed

Portela, Margareth Crisóstomo; Pronovost, Peter J; Woodcock, Thomas; Carter, Pam; Dixon-Woods, Mary

2015-05-01

Improvement (defined broadly as purposive efforts to secure positive change) has become an increasingly important activity and field of inquiry within healthcare. This article offers an overview of possible methods for the study of improvement interventions. The choice of available designs is wide, but debates continue about how far improvement efforts can be simultaneously practical (aimed at producing change) and scientific (aimed at producing new knowledge), and whether the distinction between the practical and the scientific is a real and useful one. Quality improvement projects tend to be applied and, in some senses, self-evaluating. They are not necessarily directed at generating new knowledge, but reports of such projects if well conducted and cautious in their inferences may be of considerable value. They can be distinguished heuristically from research studies, which are motivated by and set out explicitly to test a hypothesis, or otherwise generate new knowledge, and from formal evaluations of improvement projects. We discuss variants of trial designs, quasi-experimental designs, systematic reviews, programme evaluations, process evaluations, qualitative studies, and economic evaluations. We note that designs that are better suited to the evaluation of clearly defined and static interventions may be adopted without giving sufficient attention to the challenges associated with the dynamic nature of improvement interventions and their interactions with contextual factors. Reconciling pragmatism and research rigour is highly desirable in the study of improvement. Trade-offs need to be made wisely, taking into account the objectives involved and inferences to be made. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Computer technology applications in industrial and organizational psychology.

PubMed

Crespin, Timothy R; Austin, James T

2002-08-01

This article reviews computer applications developed and utilized by industrial-organizational (I-O) psychologists, both in practice and in research. A primary emphasis is on applications developed for Internet usage, because this "network of networks" changes the way I-O psychologists work. The review focuses on traditional and emerging topics in I-O psychology. The first topic involves information technology applications in measurement, defined broadly across levels of analysis (persons, groups, organizations) and domains (abilities, personality, attitudes). Discussion then focuses on individual learning at work, both in formal training and in coping with continual automation of work. A section on job analysis follows, illustrating the role of computers and the Internet in studying jobs. Shifting focus to the group level of analysis, we briefly review how information technology is being used to understand and support cooperative work. Finally, special emphasis is given to the emerging "third discipline" in I-O psychology research-computational modeling of behavioral events in organizations. Throughout this review, themes of innovation and dissemination underlie a continuum between research and practice. The review concludes by setting a framework for I-O psychology in a computerized and networked world.

How much is too much? (Part 1) International Olympic Committee consensus statement on load in sport and risk of injury.

PubMed

Soligard, Torbjørn; Schwellnus, Martin; Alonso, Juan-Manuel; Bahr, Roald; Clarsen, Ben; Dijkstra, H Paul; Gabbett, Tim; Gleeson, Michael; Hägglund, Martin; Hutchinson, Mark R; Janse van Rensburg, Christa; Khan, Karim M; Meeusen, Romain; Orchard, John W; Pluim, Babette M; Raftery, Martin; Budgett, Richard; Engebretsen, Lars

2016-09-01

Athletes participating in elite sports are exposed to high training loads and increasingly saturated competition calendars. Emerging evidence indicates that poor load management is a major risk factor for injury. The International Olympic Committee convened an expert group to review the scientific evidence for the relationship of load (defined broadly to include rapid changes in training and competition load, competition calendar congestion, psychological load and travel) and health outcomes in sport. We summarise the results linking load to risk of injury in athletes, and provide athletes, coaches and support staff with practical guidelines to manage load in sport. This consensus statement includes guidelines for (1) prescription of training and competition load, as well as for (2) monitoring of training, competition and psychological load, athlete well-being and injury. In the process, we identified research priorities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Genome-wide transcription responses to synchrotron microbeam radiotherapy.

PubMed

Sprung, Carl N; Yang, Yuqing; Forrester, Helen B; Li, Jason; Zaitseva, Marina; Cann, Leonie; Restall, Tina; Anderson, Robin L; Crosbie, Jeffrey C; Rogers, Peter A W

2012-10-01

The majority of cancer patients achieve benefit from radiotherapy. A significant limitation of radiotherapy is its relatively low therapeutic index, defined as the maximum radiation dose that causes acceptable normal tissue damage to the minimum dose required to achieve tumor control. Recently, a new radiotherapy modality using synchrotron-generated X-ray microbeam radiotherapy has been demonstrated in animal models to ablate tumors with concurrent sparing of normal tissue. Very little work has been undertaken into the cellular and molecular mechanisms that differentiate microbeam radiotherapy from broad beam. The purpose of this study was to investigate and compare the whole genome transcriptional response of in vivo microbeam radiotherapy versus broad beam irradiated tumors. We hypothesized that gene expression changes after microbeam radiotherapy are different from those seen after broad beam. We found that in EMT6.5 tumors at 4-48 h postirradiation, microbeam radiotherapy differentially regulates a number of genes, including major histocompatibility complex (MHC) class II antigen gene family members, and other immunity-related genes including Ciita, Ifng, Cxcl1, Cxcl9, Indo and Ubd when compared to broad beam. Our findings demonstrate molecular differences in the tumor response to microbeam versus broad beam irradiation and these differences provide insight into the underlying mechanisms of microbeam radiotherapy and broad beam.

Effects of Clinical Pathways for Common Outpatient Infections on Antibiotic Prescribing

PubMed Central

Jenkins, Timothy C.; Irwin, Amy; Coombs, Letoynia; DeAlleaume, Lauren; Ross, Stephen E.; Rozwadowski, Jeanne; Webster, Brian; Dickinson, L. Miriam; Sabel, Allison L.; MacKenzie, Thomas D.; West, David R.; Price, Connie S.

2013-01-01

Background Antibiotic overuse in the primary care setting is common. Our objective was to evaluate the effect of a clinical pathway-based intervention on antibiotic use. Methods Eight primary care clinics were randomized to receive clinical pathways for upper respiratory infection, acute bronchitis, acute rhinosinusitis, pharyngitis, acute otitis media, urinary tract infection, skin infections, and pneumonia and patient education materials (study group) versus no intervention (control group). Generalized linear mixed effects models were used to assess trends in antibiotic prescriptions for non-pneumonia acute respiratory infections and broad-spectrum antibiotic use for all eight conditions during a 2-year baseline and 1-year intervention period. Results In the study group, antibiotic prescriptions for non-pneumonia acute respiratory infections decreased from 42.7% of cases at baseline to 37.9% during the intervention period (11.2% relative reduction) (p <.0001) and from 39.8% to 38.7%, respectively, in the control group (2.8% relative reduction) (p=0.25). Overall use of broad-spectrum antibiotics in the study group decreased from 26.4% to 22.6% of cases, respectively, (14.4% relative reduction) (p <.0001) and from 20.0% to 19.4%, respectively, in the control group (3.0% relative reduction) (p=0.35). There were significant differences in the trends of prescriptions for acute respiratory infections (p<.0001) and broad-spectrum antibiotic use (p=0.001) between the study and control groups during the intervention period, with greater declines in the study group. Conclusions This intervention was associated with declining antibiotic prescriptions for non-pneumonia acute respiratory infections and use of broad-spectrum antibiotics over the first year. Evaluation of the impact over a longer study period is warranted. PMID:23507206

Analysis of Fatty Acid and Growth Profiles in Ten Shewanella spp. to Associate Phylogenetic Relationships

DTIC Science & Technology

2015-10-25

in a defined medium composed of half-strength Marine Broth adjusted to pH 6, 7, or 8 in a 50 mM phosphate buffer, both growth characteristics and...work had broad phylogenetic diversity (Fig. 1) and were isolated from mostly marine environments. S. putrefaciens was the only strain that was not...the defined medium that supported growth of most of the strains tested was marine broth diluted to half strength with 50 mM phosphate buffer (½-MB

Age-Related Differences in Clinical Characteristics and Esophageal Motility in Patients with Dysphagia.

PubMed

Nakato, Rui; Manabe, Noriaki; Kamada, Tomoari; Matsumoto, Hideo; Shiotani, Akiko; Hata, Jiro; Haruma, Ken

2017-06-01

Dysphagia in elderly patients has a major effect on nutrition and quality of life (QOL). Although several studies have shown that aging itself is associated with changes in esophageal motility, the impact of these changes on dysphagia symptoms and QOL is unknown. This study assessed the manometric diagnoses of elderly patients with dysphagia compared with diagnoses in younger counterparts. Participants included 116 consecutive patients examined for dysphagia from 2007 to 2014. We divided patients into three groups by age: Group A, 66 years and older (24 men, 23 women); Group B, 45-65 years (18 men, 24 women); and Group C, 44 years and younger (15 men, 12 women). The three groups were compared in regard to symptoms, esophageal motility, and health-related QOL (HRQOL). All patients underwent esophageal manometry examination and completed a self-administered questionnaire concerning their symptoms; HRQOL assessment was based on results of the Short Form-8 General Health Survey. Symptoms rated ≥4 points on the Likert scale were defined as significant. Although all patients had dysphagia as a major symptom, more elderly patients reported globus sensation, whereas more young patients reported heartburn as the primary symptom. Manometric diagnoses were generally similar across the three groups. Ineffective esophageal motility was more prevalent in Groups A and C than in Group B, although the difference was not statistically significant. No significant differences in manometric parameters or HRQOL were detected among the three groups. Despite differences in symptom patterns, broad manometric diagnoses and impairment of HRQOL in elderly patients with dysphagia are similar to those in younger counterparts.

The Principles of Engineering Immune Cells to Treat Cancer

PubMed Central

Lim, Wendell A.; June, Carl H.

2017-01-01

Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a powerful new class of cancer therapeutics. Clinical experience has helped to define the major challenges that must be met to make engineered T cells a reliable, safe, and effective platform that can be deployed against a broad range of tumors. The emergence of synthetic biology approaches for cellular engineering is providing us with a broadly expanded set of tools for programming immune cells. We discuss how these tools could be used to design the next generation of smart T cell precision therapeutics. PMID:28187291

Particle and field characteristics of the high-latitude plasma sheet boundary layer

NASA Technical Reports Server (NTRS)

Parks, G. K.; Mccarthy, M.; Fitzenreiter, R. J.; Ogilvie, K. W.; Etcheto, J.; Anderson, K. A.; Lin, R. P.; Anderson, R. R.; Eastman, T. E.; Frank, L. A.

1984-01-01

Particle and field data obtained by eight ISEE spacecraft experiments are used to define more precisely the characteristics of the high-latitude boundary region of the plasma sheet. A region immediately adjacent to the high-latitude plasma sheet boundary has particle and field characteristics distinctly different from those observed in the lobe and deeper in the central plasma sheet. Electrons over a broad energy interval are 'field-aligned' and bidirectional, whereas in the plasma sheet the distributions are more isotropic. The region supports intense ion flows, large-amplitude electric fields, and enhanced broad-band electrostatic noise.

An Object-Oriented Software Architecture for the Explorer-2 Knowledge Management Environment

PubMed Central

Tarabar, David B.; Greenes, Robert A.; Slosser, Eric T.

1989-01-01

Explorer-2 is a workstation based environment to facilitate knowledge management. It provides consistent access to a broad range of knowledge on the basis of purpose, not type. We have developed a software architecture based on Object-Oriented programming for Explorer-2. We have defined three classes of program objects: Knowledge ViewFrames, Knowledge Resources, and Knowledge Bases. This results in knowledge management at three levels: the screen level, the disk level and the meta-knowledge level. We have applied this design to several knowledge bases, and believe that there is a broad applicability of this design.

Advancing cellulose-based nanotechnology

Treesearch

Theodore H. Wegner; Philip E. Jones

2006-01-01

Nanotechnology has applications across most economic sectors and allows the development of new enabling science with broad commercial potential. Cellulose and lignocellulose have great potential as nanomaterials because they are abundant, renewable, have a nanofibrillar structure, can be made multifunctional, and self-assemble into well-defined architectures. To...

Integrative Learning: A Grounded Theory

ERIC Educational Resources Information Center

Leonard, Jeannie Brown

2012-01-01

This article reports the findings from a study of undergraduate students in an academic program focused on integrative learning rather than interdisciplinarity. One aspect of this study included how students defined integrative learning. This participant-shaped understanding of integrative learning was broad and reflected a continuum of…

ENVIRONMENTAL HEALTH

EPA Science Inventory

Are you healthy? Is your environment healthy for you? What does it mean to be healthy? Does it mean you're not achy, or that you are not visibly sick? The World Health Organization defines health broadly as a state of physical, mental, and social well-being. This means that bei...

Reach for Reference. Science Online

ERIC Educational Resources Information Center

Safford, Barbara Ripp

2004-01-01

This brief article describes the database, Science Online, from Facts on File. Science is defined broadly in this database to include archeology, computer technology, medicine, inventions, and mathematics, as well as biology, chemistry, earth sciences, and astronomy. Content also is divided into format categories for browsing purposes:…

Spanish Language Health Materials: A Selective Bibliography.

ERIC Educational Resources Information Center

Trujillo, Roberto G., Ed.; And Others

This selected bibliography, compiled from recommendations by practicing librarians providing service to Spanish-speaking communities, includes Spanish and bilingual Spanish/English materials dealing with health. The topic is broadly defined to include any conditions which affect a person's well-being, and includes alcohol and drugs, consumer…

The Mythos of the Electronic Church.

ERIC Educational Resources Information Center

Schultze, Quentin J.

1987-01-01

Considers the broad appeal of broadcast evangelism among conservative American Protestants although it is an ineffective and inefficient means of evangelization. Defines, describes, and examines the mythos as represented in the rhetoric of various well-known broadcast evangelists and their trade association, National Religious Broadcasters.…

Defining a Computational Framework for the Assessment of Taxonomic Applicability

EPA Science Inventory

The Adverse Outcome Pathway (AOP) framework describes the effects of environmental stressors across multiple scales of biological organization and function. This includes an evaluation of the potential for each key event to occur across a broad range of species in order to determ...

User Authentication from Web Browsing Behavior

DTIC Science & Technology

2013-05-01

ourselves with a cognitive personal fingerprint. Attribution is broadly defined as the assignment of an ef- fect to a cause. We differentiate between...reusable patterns of behavior. We encode the semantic and stylistic content Figure 4: Burstiness profile below 1 min aggregated across all sessions for

Air Quality and Heart Health: Managing an Emerging Cardiovascular Risk Factor

EPA Science Inventory

Dr. Cascio will share with a broad range of federal agencies current understanding of the links between air quality and cardiovascular health. The key facts include that air pollution contributes a high attributable health burden. That certain well-defined vulnerable subpopulat...

Organizational Science

ERIC Educational Resources Information Center

Beriwal, Madhu; Clegg, Stewart; Collopy, Fred; McDaniel, Reuben, Jr.; Morgan, Gareth; Sutcliffe, Kathleen; Kaufman, Roger; Marker, Anthony; Selwyn, Neil

2013-01-01

Scholars representing the field of organizational science, broadly defined as including many fields--organizational behavior and development, management, workplace performance, and so on--were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might…

Ecology, Microbial

DOE Office of Scientific and Technical Information (OSTI.GOV)

Konopka, Allan

2009-05-15

Microbial ecology is a relatively young discipline within the field of microbiology. Its modern history spans just the past 60 years, and the field is defined by its emphasis on understanding the interactions of microbes with their environment, rather than their behavior under artificial laboratory conditions. Because microbes are ubiquitous, microbial ecologists study a broad diversity of habitats that range from aquatic to terrestrial to plant- or animal-associated. This has made it a challenge to identify unifying principles within the field. One approach is to recognize that although the activity of microbes in nature have effects at the macroscale, theymore » interact with their physical, chemical and biological milieu at a scale of micrometers. At this scale, several different microbial ecosystems can be defined, based upon association with particles, the presence of environmental gradients and the continuous availability of water. Principles applicable to microbial ecology reflect not only their population ecology and physiological ecology, but also their broad versatility and quantitative importance in the biosphere as biogeochemical catalysts and capacity for rapid physiological and evolutionary responses.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Konopka, Allan

Microbial ecology is a relatively young discipline within the field of microbiology. Its modern history spans just the past 60 years, and the field is defined by its emphasis on understanding the interactions of microbes with their environment, rather than their behavior under artificial laboratory conditions. Because microbes are ubiquitous, microbial ecologists study a broad diversity of habitats that range from aquatic to terrestrial to plant- or animal-associated. This has made it a challenge to identify unifying principles within the field. One approach is to recognize that although the activity of microbes in nature have effects at the macroscale, theymore » interact with their physical, chemical and biological milieu at a scale of micrometers. At this scale, several different microbial ecosystems can be defined, based upon association with particles, the presence of environmental gradients and the continuous availability of water. Principles applicable to microbial ecology reflect not only their population ecology and physiological ecology, but also their broad versatility and quantitative importance in the biosphere as biogeochemical catalysts and capacity for rapid physiological and evolutionary responses.« less

Tree species from different functional groups respond differently to environmental changes during establishment.

PubMed

Barbosa, Eduardo R M; van Langevelde, Frank; Tomlinson, Kyle W; Carvalheiro, Luísa G; Kirkman, Kevin; de Bie, Steven; Prins, Herbert H T

2014-04-01

Savanna plant communities change considerably across time and space. The processes driving savanna plant species diversity, coexistence and turnover along environmental gradients are still unclear. Understanding how species respond differently to varying environmental conditions during the seedling stage, a critical stage for plant population dynamics, is needed to explain the current composition of plant communities and to enable us to predict their responses to future environmental changes. Here we investigate whether seedling response to changes in resource availability, and to competition with grass, varied between two functional groups of African savanna trees: species with small leaves, spines and N-fixing associations (fine-leaved species), and species with broad leaves, no spines, and lacking N-fixing associations (broad-leaved species). We show that while tree species were strongly suppressed by grass, the effect of resource availability on seedling performance varied considerably between the two functional groups. Nutrient inputs increased stem length only of broad-leaved species and only under an even watering treatment. Low light conditions benefited mostly broad-leaved species' growth. Savannas are susceptible to ongoing global environment changes. Our results suggest that an increase in woody cover is only likely to occur in savannas if grass cover is strongly suppressed (e.g. by fire or overgrazing). However, if woody cover does increase, broad-leaved species will benefit most from the resulting shaded environments, potentially leading to an expansion of the distribution of these species. Eutrophication and changes in rainfall patterns may also affect the balance between fine- and broad-leaved species.

[Does the prescribing of antibiotics in paediatrics improve after a multidisciplinary intervention?].

PubMed

Lalana-Josa, Pilar; Laclaustra-Mendizábal, Blanca; Aza-Pascual-Salcedo, M Mercedes; Carcas-de-Benavides, Cristina; Lallana-Álvarez, M Jesús; Pina-Gadea, M Belén

2015-02-01

Antibiotics overuse is linked to elevated antimicrobial resistance. In Aragon, Spain, the highest antibiotic prescription rates occur among children from 1 to 4 years old. The rate of use in this age group is over 60%. To evaluate the effect of multi-faceted intervention on Primary Care paediatricians to reduce antibiotic use and to improve antibiotic prescribing for paediatric outpatients. Outpatient antimicrobial prescribing was analysed before and after an intervention in paediatricians. The intervention included a clinical education session about diagnosis and treatment in the most prevalent paediatric infectious diseases, a clinical interview and communication skills, a workshop on rapid Streptococcus antigen detection test and patient information leaflets and useful internet websites for parents. The control group included paediatricians without this educational intervention on antibiotics. Antibiotic prescribing decreased from 19.17 defined daily doses per 1000 inhabitants/day (DID) to 14.36 DID among intervention paediatricians vs 19.84 DID to 16.02 DID in controls. The decreasing was higher in the intervention group, but the effect was not statistically significant. Macrolides and broad-spectrum penicillins prescribing decreased in both groups. Antibiotic prescribing decreased, but there were no statistically significant differences between the two groups. The high satisfaction of paediatricians in the intervention group makes it necessary to continue with these kinds of strategies to improve antibiotic use in outpatients. Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Broad- versus Narrow-Spectrum Oral Antibiotic Transition and Outcomes in Health Care-associated Pneumonia.

PubMed

Buckel, Whitney R; Stenehjem, Edward; Sorensen, Jeff; Dean, Nathan; Webb, Brandon

2017-02-01

Guidelines recommend a switch from intravenous to oral antibiotics once patients who are hospitalized with pneumonia achieve clinical stability. However, little evidence guides the selection of an oral antibiotic for patients with health care-associated pneumonia, especially where no microbiological diagnosis is made. To compare outcomes between patients who were transitioned to broad- versus narrow-spectrum oral antibiotics after initially receiving broad-spectrum intravenous antibiotic coverage. We performed a secondary analysis of an existing database of adults with community-onset pneumonia admitted to seven Utah hospitals. We identified 220 inpatients with microbiology-negative health care-associated pneumonia from 2010 to 2012. After excluding inpatient deaths and treatment failures, 173 patients remained in which broad-spectrum intravenous antibiotics were transitioned to an oral regimen. We classified oral regimens as broad-spectrum (fluoroquinolone) versus narrow-spectrum (usually a β-lactam). We compared demographic and clinical characteristics between groups. Using a multivariable regression model, we adjusted outcomes by severity (electronically calculated CURB-65), comorbidity (Charlson Index), time to clinical stability, and length of intravenous therapy. Age, severity, comorbidity, length of intravenous therapy, and clinical response were similar between the two groups. Observed 30-day readmission (11.9 vs. 21.4%; P = 0.26) and 30-day all-cause mortality (2.3 vs. 5.3%; P = 0.68) were also similar between the narrow and broad oral antibiotic groups. In multivariable analysis, we found no statistically significant differences for adjusted odds of 30-day readmission (adjusted odds ratio, 0.56; 95% confidence interval, 0.06-5.2; P = 0.61) or 30-day all-cause mortality (adjusted odds ratio, 0.55; 95% confidence interval, 0.19-1.6; P = 0.26) between narrow and broad oral antibiotic groups. On the basis of analysis of a limited number of patients observed retrospectively, our findings suggest that it may be safe to switch from broad-spectrum intravenous antibiotic coverage to a narrow-spectrum oral antibiotic once clinical stability is achieved for hospitalized patients with health care-associated pneumonia when no microbiological diagnosis is made. A larger retrospective study with propensity matching or regression-adjusted test of equivalence or ideally a prospective comparative effectiveness study will be necessary to confirm our observations.

The ROSAT Deep Survey. 2; Optical Identification, Photometry and Spectra of X-Ray Sources in the Lockman Field

NASA Technical Reports Server (NTRS)

Schmidt, M.; Hasinger, G.; Gunn, J.; Schneider, D.; Burg, R.; Giacconi, R.; Lehmann, I.; MacKenty, J.; Truemper, J.; Zamorani, G.

1998-01-01

The ROSAT Deep Survey includes a complete sample of 50 X-ray sources with fluxes in the 0.5 - 2 keV band larger than 5.5 x 10(exp -15)erg/sq cm/s in the Lockman field (Hasinger et al., Paper 1). We have obtained deep broad-band CCD images of the field and spectra of many optical objects near the positions of the X-ray sources. We define systematically the process leading to the optical identifications of the X-ray sources. For this purpose, we introduce five identification (ID) classes that characterize the process in each case. Among the 50 X-ray sources, we identify 39 AGNs, 3 groups of galaxies, 1 galaxy and 3 galactic stars. Four X-ray sources remain unidentified so far; two of these objects may have an unusually large ratio of X-ray to optical flux.

The evolution of cyclopropenium ions into functional polyelectrolytes

PubMed Central

Jiang, Yivan; Freyer, Jessica L.; Cotanda, Pepa; Brucks, Spencer D.; Killops, Kato L.; Bandar, Jeffrey S.; Torsitano, Christopher; Balsara, Nitash P.; Lambert, Tristan H.; Campos, Luis M.

2015-01-01

Versatile polyelectrolytes with tunable physical properties have the potential to be transformative in applications such as energy storage, fuel cells and various electronic devices. Among the types of materials available for these applications, nanostructured cationic block copolyelectrolytes offer mechanical integrity and well-defined conducting paths for ionic transport. To date, most cationic polyelectrolytes bear charge formally localized on heteroatoms and lack broad modularity to tune their physical properties. To overcome these challenges, we describe herein the development of a new class of functional polyelectrolytes based on the aromatic cyclopropenium ion. We demonstrate the facile synthesis of a series of polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties. The materials exhibit high ionic conductivity and thermal stability due to the nature of the cationic moieties, thus rendering this class of new materials as an attractive alternative to develop ion-conducting membranes. PMID:25575214

Identification of novel anelloviruses with broad diversity in UK rodents

PubMed Central

Nishiyama, Shoko; Dutia, Bernadette M.; Stewart, James P.; Meredith, Anna L.; Shaw, Darren J.; Simmonds, Peter

2014-01-01

Anelloviruses are a family of small circular ssDNA viruses with a vast genetic diversity. Human infections with the prototype anellovirus, torque teno virus (TTV), are ubiquitous and related viruses have been described in a number of other mammalian hosts. Despite over 15 years of investigation, there is still little known about the pathogenesis and possible disease associations of anellovirus infections, arising in part due to the lack of a robust cell culture system for viral replication or tractable small-animal model. We report the identification of diverse anelloviruses in several species of wild rodents. The viruses are highly prevalent in wood mice (Apodemus sylvaticus) and field voles (Microtus agrestis), detectable at a low frequency in bank voles (Myodes glareolus), but absent from house mice (Mus musculus). The viruses identified have a genomic organization consistent with other anelloviruses, but form two clear phylogenetic groups that are as distinct from each other as from defined genera. PMID:24744300

Initial Technology Assessment for the Large-Aperture UV-Optical-Infrared (LUVOIR) Mission Concept Study

NASA Technical Reports Server (NTRS)

Bolcar, Matthew R.; Feinberg, Lee; France, Kevin; Rauscher, Bernard J.; Redding, David; Schiminovich, David

2016-01-01

The NASA Astrophysics Division's 30-Year Roadmap prioritized a future large-aperture space telescope operating in the ultra-violet/optical/infrared wavelength regime. The Association of Universities for Research in Astronomy envisioned a similar observatory, the High Definition Space Telescope. And a multi-institution group also studied the Advanced Technology Large Aperture Space Telescope. In all three cases, a broad science case is outlined, combining general astrophysics with the search for biosignatures via direct-imaging and spectroscopic characterization of habitable exoplanets. We present an initial technology assessment that enables such an observatory that is currently being studied for the 2020 Decadal Survey by the Large UV/Optical/Infrared (LUVOIR) surveyor Science and Technology Definition Team. We present here the technology prioritization for the 2016 technology cycle and define the required technology capabilities and current state-of-the-art performance. Current, planned, and recommended technology development efforts are also reported.

Children's Interstitial and Diffuse Lung Disease. Progress and Future Horizons.

PubMed

Deterding, Robin R

2015-10-01

Children's interstitial and diffuse lung disease (chILD) is a term that encompasses a large and diverse group of rare pediatric diseases and disorders. Significant progress has been made over the last 2 decades in classification, clinical care, research, and organizational structure to enhance the care of children with these high-morbidity and -mortality diseases. New diseases have been defined clinically and genetically, classification systems developed and applied, organizations formed such as the chILD Research Network (chILDRN) and chILD Foundation, and basic and translational science expanded to focus on chILD diseases. Multidisciplinary collaborations and efforts to advance understanding and treatment of chILD have been extended worldwide. The future horizon holds great promise to expand scientific discoveries, collaborate more broadly, and bring new treatment to these children. An overview of key historical past developments, major clinical and research updates, and opportunities for the future in chILD is reviewed in this Perspective.

Applications of tethers in space: A review of workshop recommendations

NASA Technical Reports Server (NTRS)

Vontiesenhausen, G. (Editor)

1986-01-01

Well-organized and structured efforts of considerable magnitude involving NASA, industry, and academia have explored and defined the engineering and technological requirements of the use of tethers in space and have discovered their broad range of operational and economic benefits. The results of these efforts have produced a family of extremely promising candidate applications. The extensive efforts now in progress are gaining momentum and a series of flight demonstrations are being planned and can be expected to take place in a few years. This report provides an analysis and a review of NASA's second major workshop on Applications of Tethers in Space held in October 15 to 17, 1985, in Venice, Italy. It provides a summary of an up-to-date assessment and recommendations by the NASA Tether Applications in Space Program Planning Group, consisting of representatives of seven NASA Centers and responsible for tether applications program planning implementation as recommended by the workshop panels.

Clinical and radiological assessment of a family with mild brachydactyly type A1: the usefulness of metacarpophalangeal profiles.

PubMed

Armour, C M; Bulman, D E; Hunter, A G

2000-04-01

The brachydactylies are a group of conditions in which various subtypes have been defined based upon the specific pattern of digital bones involved. Type A1 brachydactyly is principally characterised by maximal involvement of the middle phalanges. We report an extended family with a mild brachydactyly A1 which was, except for some short stature, not associated with any of the additional clinical findings reported in several published families. While all the hand bones tended to be small, the principal features of the affected members were shortened middle and distal phalanges, proximal 1st phalanges, and 5th metacarpals. The feet were similarly involved and tended to have a broad, slightly adducted forefoot. The two affected children showed multiple coned epiphyses. This paper provides a detailed description of the family including the radiographic signs and metacarpophalangeal profiles, which proved to be useful in distinguishing the mildly affected persons.

Dynamics of copper-phthalocyanine molecules on Au/Ge(001).

PubMed

Sotthewes, K; Heimbuch, R; Zandvliet, H J W

2015-10-07

Spatially resolved current-time scanning tunneling spectroscopy combined with current-distance spectroscopy has been used to characterize the dynamic behavior of copper-phthalocyanine (CuPc) molecules adsorbed on a Au-modified Ge(001) surface. The analyzed CuPc molecules are adsorbed in a "molecular bridge" configuration, where two benzopyrrole groups (lobes) are connected to a Au-induced nanowire, whereas the other two lobes are connected to the adjacent nanowire. Three types of lobe configurations are found: a bright lobe, a dim lobe, and a fuzzy lobe. The dim and fuzzy lobes exhibit a well-defined switching behavior between two discrete levels, while the bright lobe shows a broad oscillation band. The observed dynamic behavior is induced by electrons that are injected into the LUMO+1 orbital of the CuPc molecule. By precisely adjusting the tip-molecule distance, the switching frequency of the lobes can be tuned accurately.

Dynamics of copper-phthalocyanine molecules on Au/Ge(001)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sotthewes, K.; Heimbuch, R.; Zandvliet, H. J. W.

2015-10-07

Spatially resolved current-time scanning tunneling spectroscopy combined with current-distance spectroscopy has been used to characterize the dynamic behavior of copper-phthalocyanine (CuPc) molecules adsorbed on a Au-modified Ge(001) surface. The analyzed CuPc molecules are adsorbed in a “molecular bridge” configuration, where two benzopyrrole groups (lobes) are connected to a Au-induced nanowire, whereas the other two lobes are connected to the adjacent nanowire. Three types of lobe configurations are found: a bright lobe, a dim lobe, and a fuzzy lobe. The dim and fuzzy lobes exhibit a well-defined switching behavior between two discrete levels, while the bright lobe shows a broad oscillationmore » band. The observed dynamic behavior is induced by electrons that are injected into the LUMO+1 orbital of the CuPc molecule. By precisely adjusting the tip-molecule distance, the switching frequency of the lobes can be tuned accurately.« less

Initial Technology Assessment for the Large UV-Optical-Infrared (LUVOIR) Mission Concept Study

NASA Technical Reports Server (NTRS)

Bolcar, Matthew R.; Feinberg, Lee D.; France, Kevin; Rauscher, Bernard J.; Redding, David; Schiminovich, David

2016-01-01

The NASA Astrophysics Divisions 30-Year Roadmap prioritized a future large-aperture space telescope operating in the ultra-violet-optical-infrared wavelength regime. The Association of Universities for Research in Astronomy envisioned a similar observatory, the High Definition Space Telescope. And a multi-institution group also studied the Advanced Technology Large Aperture Space Telescope. In all three cases, a broad science case is outlined, combining general astrophysics with the search for bio-signatures via direct-imaging and spectroscopic characterization of habitable exo-planets. We present an initial technology assessment that enables such an observatory that is currently being studied for the 2020 Decadal Survey by the Large UV-Optical Infrared (LUVOIR) surveyor Science and Technology Definition Team. We present here the technology prioritization for the 2016 technology cycle and define the required technology capabilities and current state-of-the-art performance. Current, planned, and recommended technology development efforts are also reported.

Polarized IR-microscope spectra of guanidinium hydrogenselenate single crystal.

PubMed

Drozd, M; Baran, J

2005-10-01

The polarized IR-microscope spectra of C(NH2)3.HSeO4 small single crystal samples were measured at room temperature. The spectra are discussed with the framework of oriented gas model approximation and group theory. The stretching nuOH vibration of the hydrogen bond with the O...O distance of 2.616 A gives characteristic broad AB-type absorption in the IR spectra. The changes of intensity of the AB bands in function of polarizer angle are described. Detailed assignment for bands derived from stretching and bending modes of selenate anions and guanidinium cations were performed. The observed intensities of these bands in polarized infrared spectra were correlated with theoretical calculation of directional cosines of selected transition dipole moments for investigated crystal. The vibrational studies seem to be helpful in understanding of physical and chemical properties of described compound and also in design of new complexes with exactly defined behaviors.

Nitric Oxide in the Offensive Strategy of Fungal and Oomycete Plant Pathogens

PubMed Central

Arasimowicz-Jelonek, Magdalena; Floryszak-Wieczorek, Jolanta

2016-01-01

In the course of evolutionary changes pathogens have developed many invasion strategies, to which the host organisms responded with a broad range of defense reactions involving endogenous signaling molecules, such as nitric oxide (NO). There is evidence that pathogenic microorganisms, including two most important groups of eukaryotic plant pathogens, also acquired the ability to synthesize NO via non-unequivocally defined oxidative and/or reductive routes. Although the both kingdoms Chromista and Fungi are remarkably diverse, the experimental data clearly indicate that pathogen-derived NO is an important regulatory molecule controlling not only developmental processes, but also pathogen virulence and its survival in the host. An active control of mitigation or aggravation of nitrosative stress within host cells seems to be a key determinant for the successful invasion of plant pathogens representing different lifestyles and an effective mode of dispersion in various environmental niches. PMID:26973690

Medicine 2.0: social networking, collaboration, participation, apomediation, and openness.

PubMed

Eysenbach, Gunther

2008-08-25

In a very significant development for eHealth, broad adoption of Web 2.0 technologies and approaches coincides with the more recent emergence of Personal Health Application Platforms and Personally Controlled Health Records such as Google Health, Microsoft HealthVault, and Dossia. "Medicine 2.0" applications, services and tools are defined as Web-based services for health care consumers, caregivers, patients, health professionals, and biomedical researchers, that use Web 2.0 technologies and/or semantic web and virtual reality approaches to enable and facilitate specifically 1) social networking, 2) participation, 3) apomediation, 4) openness and 5) collaboration, within and between these user groups. The Journal of Medical Internet Research (JMIR) publishes a Medicine 2.0 theme issue and sponsors a conference on "How Social Networking and Web 2.0 changes Health, Health Care, Medicine and Biomedical Research", to stimulate and encourage research in these five areas.

Medicine 2.0: Social Networking, Collaboration, Participation, Apomediation, and Openness

PubMed Central

2008-01-01

In a very significant development for eHealth, a broad adoption of Web 2.0 technologies and approaches coincides with the more recent emergence of Personal Health Application Platforms and Personally Controlled Health Records such as Google Health, Microsoft HealthVault, and Dossia. “Medicine 2.0” applications, services, and tools are defined as Web-based services for health care consumers, caregivers, patients, health professionals, and biomedical researchers, that use Web 2.0 technologies and/or semantic web and virtual reality approaches to enable and facilitate specifically 1) social networking, 2) participation, 3) apomediation, 4) openness, and 5) collaboration, within and between these user groups. The Journal of Medical Internet Research (JMIR) publishes a Medicine 2.0 theme issue and sponsors a conference on “How Social Networking and Web 2.0 changes Health, Health Care, Medicine, and Biomedical Research”, to stimulate and encourage research in these five areas. PMID:18725354

Polarised IR-microscope spectra of guanidinium hydrogensulphate single crystal.

PubMed

Drozd, M; Baran, J

2006-07-01

Polarised IR-microscope spectra of C(NH(2))(3)*HSO(4) small single crystal samples were measured at room temperature. The spectra are discussed on the basis of oriented gas model approximation and group theory. The stretching nuOH vibration of the hydrogen bond with the Ocdots, three dots, centeredO distance of 2.603A gives characteristic broad AB-type absorption in the IR spectra. The changes of intensity of the AB bands in function of polariser angle are described. Detailed assignments for bands derived from stretching and bending modes of sulphate anions and guanidinium cations were performed. The observed intensities of these bands in polarised infrared spectra were correlated with theoretical calculation of directional cosines of selected transition dipole moments for investigated crystal. The vibrational studies seem to be helpful in understanding of physical and chemical properties of described compound and also in design of new complexes with exactly defined behaviors.

Bibliotherapy: A Critique of the Literature *

PubMed Central

Favazza, Armando R.

1966-01-01

Most of the literature on bibliotherapy has been nonscientific, because of the too broad use of the term “bibliotherapy.” The author proposes, for the sake of clarification in the literature, that “bibliotherapy” be defined as a program of selected activity involving reading materials which is planned, conducted, and controlled under the guidance of a physician as treatment for psychiatric patients and which uses, if needed, the assistance of a trained librarian. Bibliotherapy, then, falls into three categories: books prescribed for a patient, books selected by a patient, and group discussion of books. Bibliotherapy may be helpful by facilitating abreaction, projection, narcissistic gratification, verbalization, constructive thinking between interviews, and reinforcement of social and cultural patterns. Bibliotherapy is probably indicated in self-motivated neurotic patients who ask for helpful reading materials. Bibliotherapy offers no panacea, but with proper scientific study may help many patients. PMID:5325817

Identifying care actions to conserve dignity in end-of-life care.

PubMed

Brown, Hilary; Johnston, Bridget; Ostlund, Ulrika

2011-05-01

Community nurses have a central role in the provision of palliative and end-of-life care; helping people to die with dignity is an important component of this care. To conserve dignity, care should comprise a broad range of actions addressing the distress that might impact on the patient's sense of dignity. These care actions need to be defined. This study aims to suggest care actions that conserve dignity at the end of life based on evidence from local experience and community nursing practice. Data were collected by focus group interviews and analysed by framework analysis using the Chochinov model of dignity as a predefined framework. Suggestions on care actions were given in relation to all themes. As part of a multi-phase project developing and testing a dignity care pathway, this study might help community nurses to conserve dying patients' dignity.

Social cognition and its relation to psychosocial adjustment in children with nonverbal learning disabilities.

PubMed

Galway, Tanya M; Metsala, Jamie L

2011-01-01

The current study examined social cognitive skills in children with nonverbal learning disabilities (NLD) compared to normally achieving (NA) children. The relation between social cognitive skills and psychosocial adjustment was also investigated. There were no group differences on children's ability to represent orally presented social vignettes. Children with NLD were less able to recognize self-generated competent/assertive responses as the best solutions to a problem, expected fewer positive and more negative outcomes for examiner-provided competent responses, and showed a trend toward more frequently judging a story character as being mean. A social problem solving factor predicted unique variance in psychosocial adjustment beyond variance accounted for by nonverbal intelligence and nonverbal social cue interpretation. Results are discussed within a framework for which social cognitive deficits more broadly defined than encoding and interpreting nonverbal social cues contribute to the psychosocial adjustment problems of children with NLD.

Hydrophobic and Hydrophilic Au and Ag Nanoparticles. Breakthroughs and Perspectives

PubMed Central

2017-01-01

This review provides a broad look on the recent investigations on the synthesis, characterization and physico-chemical properties of noble metal nanoparticles, mainly gold and silver nanoparticles, stabilized with ligands of different chemical nature. A comprehensive review of the available literature in this field may be far too large and only some selected representative examples will be reported here, together with some recent achievements from our group, that will be discussed in more detail. Many efforts in finding synthetic routes have been performed so far to achieve metal nanoparticles with well-defined size, morphology and stability in different environments, to match the large variety of applications that can be foreseen for these materials. In particular, the synthesis and stabilization of gold and silver nanoparticles together with their properties in different emerging fields of nanomedicine, optics and sensors are reviewed and briefly commented. PMID:29280980

The evolution of cyclopropenium ions into functional polyelectrolytes

DOE PAGES

Jiang, Yivan; Freyer, Jessica L.; Cotanda, Pepa; ...

2015-01-09

We report that versatile polyelectrolytes with tunable physical properties have the potential to be transformative in applications such as energy storage, fuel cells and various electronic devices. Among the types of materials available for these applications, nanostructured cationic block copolyelectrolytes offer mechanical integrity and well-defined conducting paths for ionic transport. To date, most cationic polyelectrolytes bear charge formally localized on heteroatoms and lack broad modularity to tune their physical properties. To overcome these challenges, we describe herein the development of a new class of functional polyelectrolytes based on the aromatic cyclopropenium ion.We demonstrate the facile synthesis of a series ofmore » polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties. In conclusion, the materials exhibit high ionic conductivity and thermal stability due to the nature of the cationic moieties, thus rendering this class of new materials as an attractive alternative to develop ion-conducting membranes.« less

Sudden gains in the outpatient treatment of anorexia nervosa: A process-outcome study.

PubMed

Cartwright, Anna; Cheng, Yat Ping; Schmidt, Ulrike; Landau, Sabine

2017-10-01

Sudden gains (SGs), broadly defined as sudden symptom reductions occurring between two consecutive treatment sessions, have been associated with improved treatment outcomes in anxiety and depression. The present study is the first to formally define SGs in anorexia nervosa and explore the characteristics, demographic and baseline clinical predictors, and clinical impact of SGs in anorexia nervosa. This is a secondary analysis of data from 89 outpatients with broadly defined anorexia nervosa who received one of two psychotherapeutic interventions as part of the MOSAIC trial (Schmidt et al., 2015). SGs were defined using session-by-session body mass index (BMI) measures. This study investigated whether SGs were associated with changes in BMI, eating disorder symptomology, general psychopathology, and psychosocial impairment between baseline and 6, 12, and 24 months follow-up. SGs, experienced by 61.8% of patients, mostly occurred during the early and middle phases of treatment. A larger proportion of SGs predicted larger increases in BMI between baseline and 6, 12, and 24 months follow-up. Amongst those experiencing at least one SG, fewer days between baseline and a patient's first SG predicted a larger increase in BMI between baseline and both 6 and 12 months follow-up. The proportion and timing of SGs did not predict changes in other outcome measures. SGs in BMI during the outpatient treatment of anorexia nervosa are clinically useful predictors of longer-term weight outcomes. © 2017 Wiley Periodicals, Inc.

Schizoaffective disorder diagnosed according to different diagnostic criteria--systematic literature search and meta-analysis of key clinical characteristics and heterogeneity.

PubMed

Pagel, Tobias; Franklin, Jeremy; Baethge, Christopher

2014-03-01

Schizoaffective disorder is viewed as a heterogeneous diagnosis among psychotic illnesses. Different diagnostic systems differ in their definition with DSM (-IIIR, -IV, and -V) providing a narrower definition than RDC and ICD-10. It is unclear whether this difference is reflected in patient samples diagnosed according to different diagnostic systems. Exploratory study based on a systematic review of studies of schizoaffective disorder samples diagnosed by either RDC and ICD-10 (group of "broad criteria") or DSM-IIIR and -IV ("narrow criteria"); comparison (by Mann-Whitney-U-tests) of key characteristics, such as age, number of hospitalizations, or scores in psychometric tests, between more broadly and more narrowly defined schizoaffective disorder samples using standard deviations as a measurement of heterogeneity as well as weighted means and percentages. To reduce selection bias only studies including schizoaffective patient samples together with affective disorder and schizophrenia samples were selected. 55 studies were included, 14 employing RDC, 4 ICD-10, 20 DSM-IIIR, and 17 DSM-IV. Thirteen characteristics were compared: patients diagnosed according to broader criteria had fewer previous hospitalizations (2.2 vs. 5.4) and were both less often male (42 vs. 51%) and married (21 vs. 40%). Heterogeneity was similar in both groups but slightly higher in RDC and ICD-10 samples than in DSM-IIIR and -IV-samples: +4% regarding demographic and clinical course data and +13% regarding psychometric tests (pooled SD). Secular trends and different designs may have confounded the results and limit generalizability. Some comparisons were underpowered. Differences in diagnostic criteria are reflected in key characteristics of samples. The association of larger heterogeneity with wider diagnostic criteria supports employing standard deviations as a measurement of heterogeneity. Copyright © 2013 Elsevier B.V. All rights reserved.

Undergraduate Research and Academic Archives: Instruction, Learning and Assessment

ERIC Educational Resources Information Center

Krause, Magia G.

2010-01-01

Colleges and universities are increasingly investing resources to promote undergraduate research. Undergraduate research can be broadly defined to incorporate scientific inquiry, creative expression, and scholarship with the result of producing original work. Academic archives and special collections can play a vital role in the undergraduate…

Learning Systems in Post-Statutory Education

ERIC Educational Resources Information Center

Catherall, Paul

2008-01-01

This article examines the broad scope of systemised learning (e-learning) in post-statutory education. Issues for discussion include the origins and forms of learning systems, including technical and educational concepts and approaches, such as distributed and collaborative learning. The VLE (Virtual Learning Environment) is defined as the…

Climate change impacts on terrestrial ecosystems in the multi-state region centered on Chicago

USDA-ARS?s Scientific Manuscript database

This paper describes the potential impacts of warming temperatures and changing precipitation on plants wildlife, invasive species, pests and agricultural ecosystems across the multistate region centered on Chicago, Illinois. We define the region broadly to include several hundred kilometers. We c...

Two Linguists on Freshman English: Pressure from Below.

ERIC Educational Resources Information Center

Francis, W. Nelson

1964-01-01

The importance of improving English instructors' attitudes toward three broadly classified forms of language expression is examined. The author notes an increased interest in languages among college freshmen and defines the differences between (1) artistic, (2) playful, and (3) intellectual expression. Pressure resulting from advanced teaching…

The Workforce Education and Development in Taiwan

ERIC Educational Resources Information Center

Lee, Lung-Sheng

2012-01-01

Workforce education and development (WED) can be broadly defined as those formal, informal and nonformal activities that prepare people for work. In Taiwan, it includes technological and vocational education (TVE), human resource development (HRD), public vocational training and adult education. In order to promote information exchanges and…

Publish or perish: authorship and peer review

USDA-ARS?s Scientific Manuscript database

Publish or perish is defined in Wikipedia as the pressure to publish work constantly to further or sustain one’s career in academia. This is an apt description given that refereed scientific publications are the currency of science and the primary means for broad dissemination of knowledge. Professi...

Developing guidelines for elementary flow nomenclature

EPA Science Inventory

In general, a flow in life cycle inventory data refers to an input or output to a process. Flows may be of two broad types: elementary flows or intermediate (known as “technosphere”) flows according to ISO 14044 (ISO 14044 2006). Elementary flows may be defined as mat...

"Sustaining the Shrinking City: Concepts, Dynamics and Management" (A special issue of Sustainability) (ISSN 2071-1050).

EPA Science Inventory

Sustainability can be broadly defined as the resilient outcome of the interaction among social equity, economic stability, and environmental quality factors. For example, the utilization of natural resource capitals are constrained by economic forces, and further modulated by soc...

19 CFR 10.450 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Chile Free Trade Agreement Rules of Origin § 10.450 Definitions. For purposes of §§ 10.450 through 10.463 of this subpart: (a..., rules, and procedures, including both broad and specific guidelines, that define the accounting...

Vision Science and Technology at NASA: Results of a Workshop

NASA Technical Reports Server (NTRS)

Watson, Andrew B. (Editor); Mulligan, Jeffrey B. (Editor)

1990-01-01

A broad review is given of vision science and technology within NASA. The subject is defined and its applications in both NASA and the nation at large are noted. A survey of current NASA efforts is given, noting strengths and weaknesses of the NASA program.

HOLISTIC APPROACH FOR ASSESSING THE PRESENCE AND POTENTIAL IMPACTS OF WATERBORNE ENVIRONMENTAL CONTAMINANTS

EPA Science Inventory

As an integral part of our continuing research in environmental quality assessment approaches, we have developed a variety of passive integrative sampling devices widely applicable for use in defining the presence and potential impacts of a broad array of contaminants. The semipe...

A Retrospective on Educational Planning in Comparative Education.

ERIC Educational Resources Information Center

Farrell, Joseph P.

1997-01-01

Defines and broadly traces the history of educational planning in both developing and industrialized capitalist nations. Discusses general approaches to educational planning (technical versus political planning, top-down versus bottom-up planning, and various theoretical bases); the contingency view of planning; case examples of planned,…

Development of a publicly available, comprehensive database of fiber and health outcomes: rationale and methods

USDA-ARS?s Scientific Manuscript database

Background: Dietary fiber is a broad category of compounds historically defined as partially or completely indigestible plant-based carbohydrates and lignin with, more recently, the additional criteria that fibers incorporated into foods as additives should demonstrate functional human health outcom...

The Convergence Years

ERIC Educational Resources Information Center

Kolodzy, Janet; Grant, August E.; DeMars, Tony R.; Wilkinson, Jeffrey S.

2014-01-01

The emergence of the Internet, social media, and digital technologies in the twenty-first century accelerated an evolution in journalism and communication that fit under the broad term of convergence. That evolution changed the relationship between news producers and consumers. It broke down the geographical boundaries in defining our communities,…

Synthetic pesticides in agro-ecosystems: are they as detrimental to nontarget invertebrate fauna as we suspect?

PubMed

Jenkins, Sommer; Hoffmann, Ary A; Mccoll, Stuart; Tsitsilas, Angelos; Umina, Paul A

2013-04-01

Broad-spectrum pesticides used to protect field crops and pastures from invertebrate pests are frequently reported to reduce populations of nontarget fauna, but there is often little relevant field data. Nonetheless, this notion is used to promote the adoption of more selective pesticides with less impact on nontarget invertebrates, including beneficial insects. Selective pesticides are not widely available for broad-acre grain crops and pastures in southern Australia; however, several options available in other industries could be compatible with these agricultural systems. In this study, the impact of broad-spectrum pesticides and several selective pesticides on nontarget invertebrate fauna was assessed in five field trials in wheat and canola fields. Despite extensive sampling over short and medium timeframes, few treatment effects on nontarget groups were detected. In cases where broad-spectrum pesticides were detrimental, patterns were often inconsistent among nontarget groups and between field trials. In contrast, the pest species, Halotydeus destructor Tucker and Penthaleus spp., were effectively controlled by the broad-spectrum treatments and less effectively by the selective pesticides. The inconsistent and relatively small impact of broad-spectrum pesticides on some nontarget invertebrates demonstrates that caution is required when extrapolating from laboratory-based assessments routinely used to assess the impacts of pesticides to field conditions in agriculture.

The ototoxic effect of intratympanic terbinafine applied in the middle ear of rats

PubMed Central

2013-01-01

Background Otomycosis is defined as an infection of the external ear canal with fungal agents. The treatment of the disease is cleansing and drying of the external ear canal, identification and treatment of any predisposing factors and application of topical antifungal agents. Terbinafine is used as an antifungal agent to treat otomycosis. We proposed to investigate the probable ototoxic effect of terbinafine solution on auditory brain stem response (ABR) and distortion product otoacoustic emission (DPOAE) when applied intratympanically in the middle ear of rats. Methods The experiment was performed on 30 female Wistar albino rats. Thirty animals were divided into three groups of 10 animals each. 1% terbinafine solution was administered to the first group (group T). The second group (group G) was administered 40 mg/ml gentamicin solution (ototoxic control). The third group (group S) was administered saline solution (negative control). Baseline DPOAE measurements and ABR testing from the left ears were obtained from the animals in all groups under general anesthesia. Ear solutions were applied in the middle ear intratympanically with a dental needle. Treatment was initiated after baseline measurements and repeated once every two days for fifteen days. Results Pre and post-treatment DPOAE responses for all tested frequencies of group T and Group S showed no statistically significant difference. However, the group G demonstrated a significant change in ABR thresholds and DPOAE responses. Conclusions Terbinafine solution is a broad spectrum antifungal agent effective in the treatment of otomycosis. The present study demonstrated that its direct administration in the middle ear of rats does not affect inner ear function as measured by ABR and DPOAE responses. PMID:23663536

Staff and consumer perspectives on defining treatment success and failure in assertive community treatment.

PubMed

Stull, Laura G; McGrew, John H; Salyers, Michelle P

2010-09-01

Although assertive community treatment (ACT) has been consistently recognized as effective, there has been little research as to what constitutes success in ACT. The purpose of this study was to understand how ACT consumers and staff define treatment success and failure and to examine whether definitions varied between staff and consumers. Investigators conducted semistructured interviews with 25 staff and 23 consumers from four ACT teams. Across perspectives, success and failure were most clearly related to consumer factors. Other themes included having basic needs met, being socially involved, and taking medications. Reduced hospitalizations were mentioned infrequently. Consumers were more likely than staff to identify the level or type of treatment as defining success and failure, whereas staff were more likely than consumers to discuss substance abuse when defining failure and improved symptoms when defining success. Success in ACT should be viewed more broadly than reduced hospitalizations and include domains such as social involvement.

2D nanomaterials assembled from sequence-defined molecules

DOE PAGES

Mu, Peng; Zhou, Guangwen; Chen, Chun-Long

2017-10-21

Two dimensional (2D) nanomaterials have attracted broad interest owing to their unique physical and chemical properties with potential applications in electronics, chemistry, biology, medicine and pharmaceutics. Due to the current limitations of traditional 2D nanomaterials (e.g., graphene and graphene oxide) in tuning surface chemistry and compositions, 2D nanomaterials assembled from sequence-defined molecules (e.g., DNAs, proteins, peptides and peptoids) have recently been developed. They represent an emerging class of 2D nanomaterials with attractive physical and chemical properties. Here, we summarize the recent progress in the synthesis and applications of this type of sequence-defined 2D nanomaterials. We also discuss the challenges andmore » opportunities in this new field.« less

2D nanomaterials assembled from sequence-defined molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mu, Peng; Zhou, Guangwen; Chen, Chun-Long

Two dimensional (2D) nanomaterials have attracted broad interest owing to their unique physical and chemical properties with potential applications in electronics, chemistry, biology, medicine and pharmaceutics. Due to the current limitations of traditional 2D nanomaterials (e.g., graphene and graphene oxide) in tuning surface chemistry and compositions, 2D nanomaterials assembled from sequence-defined molecules (e.g., DNAs, proteins, peptides and peptoids) have recently been developed. They represent an emerging class of 2D nanomaterials with attractive physical and chemical properties. Here, we summarize the recent progress in the synthesis and applications of this type of sequence-defined 2D nanomaterials. We also discuss the challenges andmore » opportunities in this new field.« less

Sustainability Considerations for Health Research and Analytic Data Infrastructures

PubMed Central

Wilcox, Adam; Randhawa, Gurvaneet; Embi, Peter; Cao, Hui; Kuperman, Gilad J.

2014-01-01

Introduction: The United States has made recent large investments in creating data infrastructures to support the important goals of patient-centered outcomes research (PCOR) and comparative effectiveness research (CER), with still more investment planned. These initial investments, while critical to the creation of the infrastructures, are not expected to sustain them much beyond the initial development. To provide the maximum benefit, the infrastructures need to be sustained through innovative financing models while providing value to PCOR and CER researchers. Sustainability Factors: Based on our experience with creating flexible sustainability strategies (i.e., strategies that are adaptive to the different characteristics and opportunities of a resource or infrastructure), we define specific factors that are important considerations in developing a sustainability strategy. These factors include assets, expansion, complexity, and stakeholders. Each factor is described, with examples of how it is applied. These factors are dimensions of variation in different resources, to which a sustainability strategy should adapt. Summary Observations: We also identify specific important considerations for maintaining an infrastructure, so that the long-term intended benefits can be realized. These observations are presented as lessons learned, to be applied to other sustainability efforts. We define the lessons learned, relating them to the defined sustainability factors as interactions between factors. Conclusion and Next Steps: Using perspectives and experiences from a diverse group of experts, we define broad characteristics of sustainability strategies and important observations, which can vary for different projects. Other descriptions of adaptive, flexible, and successful models of collaboration between stakeholders and data infrastructures can expand this framework by identifying other factors for sustainability, and give more concrete directions on how sustainability can be best achieved. PMID:25848610

The importance of product definitions in US e-cigarette laws and regulations.

PubMed

Lempert, Lauren K; Grana, Rachel; Glantz, Stanton A

2016-04-01

How electronic cigarettes and similar products (e-cigarettes) are defined affects how they are regulated, particularly whether existing laws for cigarettes apply, including sales and marketing, youth access, smoke-free and taxation laws. We examined the text of 46 bills that define e-cigarettes enacted in 40 states and characterised how e-cigarettes and similar products were defined. States enact laws creating new product categories for e-cigarettes separate from the 'tobacco product' category (eg, 'alternative nicotine product,' 'vapour product,' 'electronic nicotine device'), with four states explicitly excluding e-cigarettes from 'tobacco products.' Twenty-eight states do not include e-cigarettes in their definitions of 'tobacco products' or 'smoking,' eight include e-cigarettes as 'tobacco products,' three include e-cigarettes in 'smoking.' Sixteen states' definitions of e-cigarettes require nicotine, and five states pre-empt more stringent local laws. Tobacco and e-cigarette industry representatives tried to shape laws that benefit their interests. Definitions separating e-cigarettes from other tobacco products are common. Similar to past 'Trojan horse' policies, e-cigarette policies that initially appear to restrict sales (eg, limit youth access) may actually undermine regulation if they establish local pre-emption or create definitions that divide e-cigarettes from other tobacco products. Comparable issues are raised by the European Union Tobacco Products Directive and e-cigarette regulations in other countries. Policymakers should carefully draft legislation with definitions of e-cigarettes that broadly define the products, do not require nicotine or tobacco, do not pre-empt stronger regulations and explicitly include e-cigarettes in smoke-free and taxation laws. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

PubMed Central

Sachdev, Perminder; Kalaria, Raj; O’Brien, John; Skoog, Ingmar; Alladi, Suvarna; Black, Sandra E; Blacker, Deborah; Blazer, Dan; Chen, Christopher; Chui, Helena; Ganguli, Mary; Jellinger, Kurt; Jeste, Dilip V.; Pasquier, Florence; Paulsen, Jane; Prins, Niels; Rockwood, Kenneth; Roman, Gustavo; Scheltens, Philip

2014-01-01

Background Several sets of diagnostic criteria have been published for vascular dementia (VaD) since the 1960s. The continuing ambiguity in VaD definition warrants a critical re-examination. Methods Participants at a special symposium of the International Society for Vascular Behavioral and Cognitive Disorders (VASCOG) in 2009 critiqued the current criteria. They drafted a proposal for a new set of criteria, later reviewed through multiple drafts by the group, including additional experts and the members of the Neurocognitive Disorders Work Group of the DSM-5 Task Force. Results Cognitive disorders of vascular etiology are a heterogeneous group of disorders with diverse pathologies and clinical manifestations, discussed broadly under the rubric of vascular cognitive disorders (VCD). The continuum of vascular cognitive impairment is recognized by the categories of Mild Vascular Cognitive Disorder, and Vascular Dementia or Major Vascular Cognitive Disorder. Diagnostic thresholds are defined. Clinical and neuroimaging criteria are proposed for establishing vascular etiology. Subtypes of VCD are described, and the frequent co-occurrence of Alzheimer’s disease pathology emphasized. Conclusions The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathological validation studies. These criteria can be harmonized with the DSM-5 criteria such that an international consensus on the criteria for VCD may be achieved. PMID:24632990

It’s All of the Above: Benefits of Working for Individuals with Spinal Cord Injury

PubMed Central

Reed, Karla S.; Saunders, Lee L.; Krause, James S.

2015-01-01

Background: The majority of research on employment among persons with spinal cord injury (SCI) focuses on the employment rate at a given point in time to the exclusion of quality employment outcomes. Objective: To identify the employment outcomes of greatest importance as defined by those with SCI who have worked since injury. Methods: A qualitative approach was used with 6 focus groups at 2 sites (Minnesota and Georgia). Participants (N = 44) were a minimum of 10 years after injury and had been employed at some point after SCI. We identified participants through a 40-year longitudinal study of SCI and a community resource. A combination of homogeneous (race/ethnic minority group, female group) and heterogeneous groups were convened. A semi-structured interview format queried participants about personal, environmental, and policy-related factors that impacted obtaining, maintaining, and advancing in employment. Results: Seven overlapping themes were identified under the 2 broad categories of compensation and subjective well-being: (1) salary and what it can support, (2) health insurance and other fringe benefits, (3) promotions and recognition, (4) social connection and support, (5) job satisfaction and enjoyment from working, (6) making a difference and helping others, and (7) psychological and emotional health. Conclusion: The results indicate several common themes among persons with SCI who have successful employment histories, suggesting that the benefits of employment are multifaceted and go beyond monetary compensation. PMID:25762855

It's All of the Above: Benefits of Working for Individuals with Spinal Cord Injury.

PubMed

Meade, Michelle A; Reed, Karla S; Saunders, Lee L; Krause, James S

2015-01-01

The majority of research on employment among persons with spinal cord injury (SCI) focuses on the employment rate at a given point in time to the exclusion of quality employment outcomes. To identify the employment outcomes of greatest importance as defined by those with SCI who have worked since injury. A qualitative approach was used with 6 focus groups at 2 sites (Minnesota and Georgia). Participants (N = 44) were a minimum of 10 years after injury and had been employed at some point after SCI. We identified participants through a 40-year longitudinal study of SCI and a community resource. A combination of homogeneous (race/ethnic minority group, female group) and heterogeneous groups were convened. A semi-structured interview format queried participants about personal, environmental, and policy-related factors that impacted obtaining, maintaining, and advancing in employment. Seven overlapping themes were identified under the 2 broad categories of compensation and subjective well-being: (1) salary and what it can support, (2) health insurance and other fringe benefits, (3) promotions and recognition, (4) social connection and support, (5) job satisfaction and enjoyment from working, (6) making a difference and helping others, and (7) psychological and emotional health. The results indicate several common themes among persons with SCI who have successful employment histories, suggesting that the benefits of employment are multifaceted and go beyond monetary compensation.

Decision support system development at the Upper Midwest Environmental Sciences Center

USGS Publications Warehouse

Fox, Timothy J.; Nelson, J. C.; Rohweder, Jason J.

2014-01-01

A Decision Support System (DSS) can be defined in many ways. The working definition used by the U.S. Geological Survey Upper Midwest Environmental Sciences Center (UMESC) is, “A spatially based computer application or data that assists a researcher or manager in making decisions.” This is quite a broad definition—and it needs to be, because the possibilities for types of DSSs are limited only by the user group and the developer’s imagination. There is no one DSS; the types of DSSs are as diverse as the problems they help solve. This diversity requires that DSSs be built in a variety of ways, using the most appropriate methods and tools for the individual application. The skills of potential DSS users vary widely as well, further necessitating multiple approaches to DSS development. Some small, highly trained user groups may want a powerful modeling tool with extensive functionality at the expense of ease of use. Other user groups less familiar with geographic information system (GIS) and spatial data may want an easy-to-use application for a nontechnical audience. UMESC has been developing DSSs for almost 20 years. Our DSS developers offer our partners a wide variety of technical skills and development options, ranging from the most simple Web page or small application to complex modeling application development.

Quality standards in a rheumatology Day-Care Hospital Unit. The proposal of the Spanish Society of Rheumatology Day Hospitals' Working Group.

PubMed

García-Vicuña, Rosario; Montoro, María; Egües Dubuc, César Antonio; Bustabad Reyes, Sagrario; Gómez-Centeno, Antonio; Muñoz-Fernández, Santiago; Pérez Pampín, Eva; Román Ivorra, Jose Andrés; Balsa, Alejandro; Loza, Estíbaliz

2014-01-01

In recent years, the Rheumatology Day-Care Hospital Units (DHU have undergone extensive development. However, the quality standards are poorly documented and mainly limited to structure items rather than including broad and specific areas of this specialty. To develop specific quality standards for Rheumatology DHU. After a systematic review of the literature and related documents, a working group (WG) involving 8 DHU-experienced rheumatologists developed an initial proposal of the quality standards, under the supervision of an expert methodologist. A second round was held by the WG group to review the initial proposal and to consider further suggestions. Once the content was agreed upon by consensus, a final report was prepared. 17 structure standards, 25 process standards and 10 results standards were defined, with special emphasis on specific aspects of the Rheumatology DHU. The proposal includes: 1) essential standards to 2) excellent standards, 3) a Rheumatology DHU services portfolio and 4) performance criteria. The proposed quality standards are the basis for developing the indicators and other management tools for Rheumatology DHU, thereby ensuring a patient-oriented practice based on both the evidence and the experience. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Liability.

ERIC Educational Resources Information Center

Hollander, Patricia A.

The author notes that this chapter deals generally with torts in higher education cases. A tort is usually defined broadly to cover most wrongful civil acts, except breach of contract, that may occur between individuals. The remedy sought in a civil tort action is compensation to the injured party for the damages suffered. The areas discussed here…

Leaching Test Relationships, Laboratory-to-Field Comparisons and Recommendations for Leaching Evaluation using the Leaching Environmental Assessment Framework (LEAF)

EPA Science Inventory

This report presents examples of the relationships between the results of laboratory leaching tests, as defined by the Leaching Environmental Assessment Framework (LEAF) or analogous international test methods, and leaching of constituents from a broad range of materials under di...

Learning Transfer and Its Intentionality in Adult and Continuing Education

ERIC Educational Resources Information Center

Foley, Jeffrey M.; Kaiser, Leann M. R.

2013-01-01

Broad (1997) defined learning transfer as the "effective and continuing application by learners--to their performance of jobs or other individual, organizational, or community responsibilities--of knowledge and skills gained in the learning activities" (p. 2). This chapter offers an introduction to learning transfer and the major concepts related…

In Search of Community: Faculty Assessment of Its Presence at Three Institutions.

ERIC Educational Resources Information Center

Davis, Lloyd D.

1997-01-01

Assesses the concept of community at institutions of higher education. Compares community college, private college, and university faculty responses to a questionnaire focusing on six broad ideals that define community: disciplined, purposeful, caring, open, celebrative, and just. Concludes that faculty strongly perceive elements of community,…

Defining Antimicrobial Textile Requirements for Military Applications - A Gap Analysis

DTIC Science & Technology

2016-05-09

biocide that has broad spectrum antibacterial , antiviral, and antifungal activity . Copper behaves similarly to silver by binding and inactivating...urogenital health conditions in active duty Soldiers from 2002-2011...personnel in order to generate and update requirements and standards for incorporating anti-odor, antibacterial , and antifungal properties into CIE

75 FR 54117 - Building Energy Standards Program: Preliminary Determination Regarding Energy Efficiency...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... Response to Comments on Previous Analysis C. Summary of the Comparative Analysis 1. Quantitative Analysis 2... preliminary quantitative analysis are specific building designs, in most cases with specific spaces defined... preliminary determination. C. Summary of the Comparative Analysis DOE carried out both a broad quantitative...

Violence against Teachers: Prevalence and Consequences

ERIC Educational Resources Information Center

Wilson, Catherine M.; Douglas, Kevin S.; Lyon, David R.

2011-01-01

Data collected from 731 teachers were used to examine the consequences of violence directed toward teachers while in the workplace. Analyses showed that the majority of respondents (n = 585, 80.0%) had experienced school-related violence--broadly defined--at one point in their careers. Serious violence (actual, attempted, or threatened physical…

Those Important Things: What Every College President Needs to Know About Marketing and Student Recruitment.

ERIC Educational Resources Information Center

Sevier, Robert A.

1996-01-01

College presidents are offered nine key suggestions for marketing and student recruitment: beginning with vision; defining marketing broadly; creating institutional image; understanding how students make decisions; creating familiarity; competitive positioning; market segmentation; choosing a marketing champion respected by the college community;…

Lifelong Education: Concept or Policy?

ERIC Educational Resources Information Center

Lawson, Kenneth

1982-01-01

Suggests that lifelong education is a policy for education, and education is too broadly defined. Education should be restricted to areas of learning that produce desired effects. The place of knowledge in lifelong education is discussed, and distinction is drawn between education and training. (Availability: Falmer Press, Falmer House, Barcombe,…

SAN FRANCISCO BAY WETLANDS REGIONAL MONITORING PROGRAM

EPA Science Inventory

The geographic area to be monitored is the San Francisco Estuary and its watersheds from the Golden Gate to the Sacramento-San Joaquin Delta at Broad Slough. The initial focus will be the baylands of the region defined as the lands between the maximum and minimum elevations of t...

Assessment of General Education

ERIC Educational Resources Information Center

Furman, Tanya

2013-01-01

The assessment of general education is often approached through broad surveys or standardized instruments that fail to capture the learning goals most faculty members desire for this portion of the curriculum. The challenge in remedying this situation lies, first, in defining general education in meaningful ways that can be both articulated and…

Operationally Defining Work, Individualized Teacher Preparation.

ERIC Educational Resources Information Center

Florida State Univ., Tallahassee. Dept. of Science Education.

This publication is one of 14 modules prepared for training pre- and in-service teachers to teach Intermediate Science Curriculum Study (ISCS) materials. The organization of this publication is centered around the first unit at level I discussing the broad physics concept of "work." Various activities are suggested for teachers. This…

Agreement Reflexes of Emerging Optionality in Heritage Speaker Spanish

ERIC Educational Resources Information Center

Pascual Cabo, Diego

2013-01-01

This study contributes to current trends of heritage speaker (HS) acquisition research by examining the syntax of psych-predicates in HS Spanish. Broadly defined, psych-predicates communicate states of emotions (e.g., to love) and have traditionally been categorized as belonging to one of three classes: class I--"temere" "to…

Anxiety and Response to Reading Intervention among First Grade Students

ERIC Educational Resources Information Center

Grills, Amie E.; Fletcher, Jack M.; Vaughn, Sharon; Barth, Amy; Denton, Carolyn A.; Stuebing, Karla K.

2014-01-01

Background: For school-aged children with reading difficulties, an emerging and important area of investigation concerns determining predictors of intervention response. Previous studies have focused exclusively on cognitive and broadly defined behavioral variables. What has been missing, however, are studies examining anxiety, which is among the…

A Delineation of Epistemic Possibilities in Explanations of Cognitive Development.

ERIC Educational Resources Information Center

Price, Reese E.

Several epistemic formulations have been advanced to explain cognitive development. Many writers have divided the field of psychology into three basic underlying models: the mechanistic, organismic, and dialectic models. An examination of epistemic positions reveals five broadly defined positions on how behavior develops within a given organism.…

Automatic Syllabification in English: A Comparison of Different Algorithms

ERIC Educational Resources Information Center

Marchand, Yannick; Adsett, Connie R.; Damper, Robert I.

2009-01-01

Automatic syllabification of words is challenging, not least because the syllable is not easy to define precisely. Consequently, no accepted standard algorithm for automatic syllabification exists. There are two broad approaches: rule-based and data-driven. The rule-based method effectively embodies some theoretical position regarding the…

Embodied Computation: An Active-Learning Approach to Mobile Robotics Education

ERIC Educational Resources Information Center

Riek, L. D.

2013-01-01

This paper describes a newly designed upper-level undergraduate and graduate course, Autonomous Mobile Robots. The course employs active, cooperative, problem-based learning and is grounded in the fundamental computational problems in mobile robotics defined by Dudek and Jenkin. Students receive a broad survey of robotics through lectures, weekly…

Center for School and Community Services

ERIC Educational Resources Information Center

Academy for Educational Development, 2004

2004-01-01

The AED Center for School and Community Services has applied decades of research to pioneering successful approaches to school reform. It has also evaluated--and helped to advance--some of the most exciting initiatives in American education. In the tradition of AED, the Center defines "education" broadly. Recognizing the interdependence of many…

International Education Programs of the U.S. Government: An Inventory.

ERIC Educational Resources Information Center

Wiprud, Helen R., Comp.

This publication describes 181 international education programs sponsored by the United States government. A program is considered an international education program in this inventory if it fosters understanding and/or cooperation between the United States and another country or countries through education, which is broadly defined to include…

English Exceptionalism Re-Visited: Divergent Skill Strategies across England and Scotland

ERIC Educational Resources Information Center

Keep, Ewart

2017-01-01

This article takes as its starting point David Raffe's pioneering work on "home international" comparisons across the UK, and compares and contrasts current and emerging English and Scottish developments and policy trajectories primarily as they relate to vocational education broadly defined, but also with some observations concerning…

The national strategic plan for federal aquaculture research, specific goal #4: Improve production efficiency and well-being

USDA-ARS?s Scientific Manuscript database

The 2014-2019 National Strategic Plan for Federal Aquaculture Research identifies a series of specific goals that identify research priorities for Federal agency and interagency research programs. Collectively, these priorities define research activities with the broad outcome of supporting aquacul...

Secondary Social Studies: Alaska Curriculum Guide. Second Edition.

ERIC Educational Resources Information Center

Alaska State Dept. of Education, Juneau. Office of Curriculum Services.

A secondary social studies model curriculum guide for Alaska is presented. The body of the guide lists topics/concepts, learning outcomes/objectives, and sample learning activities in a 3 column format. The first column, topics/concepts, describes the content area, defining the subject broadly and listing subconcepts or associated vocabulary. The…

Collaborative Counseling: A Conceptual Framework and Approach for Counselors of Adults in Life Transitions.

ERIC Educational Resources Information Center

Avis, Joan P.

1987-01-01

Proposes collaborative counseling as a comprehensive definition of adult counseling. Presents rationale for definition based on broad implications for counselors of adult development and life transitions literature. Discusses three perspectives as a conceptual framework for defining the phenomenology of the counselor of adults. Outlines elements…

The genetic basis of flecking and its relationship to disease resistance in the IBM maize mapping population

USDA-ARS?s Scientific Manuscript database

Flecking is defined as a mild, often environmentally-dependent lesion phenotype observed on the leaves of several commonly used maize inbred lines. Anecdotal evidence suggests a link between flecking and enhanced broad-spectrum disease resistance. Neither the genetic basis underlying flecking nor ...

Defining Integrated Student Supports for Linked Learning Pathways. Knowledge Brief

ERIC Educational Resources Information Center

John W. Gardner Center for Youth and Their Communities, 2016

2016-01-01

This document outlines how effectively integrated student supports build or scaffold student competencies in five broad domains of learning for college, career, and civic readiness. Relevant supports are not limited to "services" or "programs" but extend to enabling resources and social conditions, including, for example,…

Self-Efficacy and Academic Listening

ERIC Educational Resources Information Center

Graham, Suzanne

2011-01-01

This paper takes as its starting point the difficulties inherent in listening in a second language. It argues that self-efficacy, broadly defined as the belief in one's ability to carry out specific tasks successfully, is crucial to the development of effective listening skills, and that listening strategy instruction has the potential to boost…

Color maps of Arp 146

NASA Technical Reports Server (NTRS)

Schultz, A. B.; Spight, L. D.; Colegrove, P. T.; Disanti, M. A.; Fink, U.

1990-01-01

Four color maps of Arp 146 are given. The structure and color of the ring galaxy and its companion show evidence of a bridge of material between the companion and the remnant nucleus of the original galaxy now forming the ring. Broad band spatial coverage clearly defines regions of starburst occurrence.

Government-Funded Program Completions 2014. Preliminary. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2015

2015-01-01

This publication provides data on Australian Qualifications Framework (AQF) programs completed from 2010 to 2014 in Australia's government-funded vocational education and training (VET) system (broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and other registered…

Government-Funded Students and Courses: January to June 2015

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2015

2015-01-01

This report provides a summary of data relating to students, programs, training providers and funding in Australia's government-funded vocational education and training (VET) system (broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and private training providers). The…

What Were Willie and Xavier Thinking? A Reflection on James Gallagher's Research on Student-Teacher Interaction

ERIC Educational Resources Information Center

Gallagher, Shelagh A.; Courtright, Richard D.; Robinson, Linda P.

2015-01-01

James Gallagher is known for framing the broad ideas that drive the field of gifted education; he defined policy, described ideal educational infrastructure, and identified "acceleration," "enrichment," "novelty," and "sophistication" as core attributes of content differentiation (J. J. Gallagher, 1985).…

Exploring the Relationship between Undergraduate Service-Learning Experiences and Global Perspective-Taking

ERIC Educational Resources Information Center

Engberg, Mark E.; Fox, Katherine

2011-01-01

This study examines the relationship between service-learning participation and global perspective-taking. A global perspective is broadly defined to include both the acquisition of knowledge, attitudes, and skills important to intercultural communication and the development of more complex epistemological processes, identities, and interpersonal…

Introduction to This Special Issue on Context-Aware Computing.

ERIC Educational Resources Information Center

Moran, Thomas P.; Dourish, Paul

2001-01-01

Discusses pervasive, or ubiquitous, computing; explains the notion of context; and defines context-aware computing as the key to disperse and enmesh computation into our lives. Considers context awareness in human-computer interaction and describes the broad topic areas of the essays included in this special issue. (LRW)

Re-Orientations in Moral Education in Cambodia Since 1975

ERIC Educational Resources Information Center

Clayton, Thomas

2005-01-01

In recent years, Cambodia has transitioned from a communist state to a liberal democracy following market economic practices. Transition in the political economy has, in turn, influenced education and, more specifically, moral education. In this article, I define moral education more broadly than many, as additionally dedicated to the preparation…

Character Education: Christian Education Perspectives

ERIC Educational Resources Information Center

Wilhelm, Gretchen M.; Firmin, Michael W.

2008-01-01

Character is defined broadly by leading authorities, including concepts such as practicing apt behavior and teaching right from wrong. Virtue and moral undertones tend to pervade most experts' use of character, although in secular settings, the notion of ethics is more prominent. Overall, developing in students a desire for the good is how most…

The Lonely Consumer: Advertising and Alienation.

ERIC Educational Resources Information Center

Larson, Charles U.; Denton, Robert E.

Advertising plays on the broad feelings of alienation (defined as an individual's frustrated or estranged responses to economic and sociological phenomena which affect that individual's place in society) which are endemic to the American consumer society and are, in Marxist views, symptomatic of any capitalist system. By generating anxieties and…

The Imperative of Service in the Professor's Role.

ERIC Educational Resources Information Center

Achilles, C. M.; Achilles, Susan H.

In the professorial role's traditional triad of teaching, research, and service, research (publishing) and teaching get more attention than service. If professors are to be part of improving education in America's schools, they must define service more broadly, and they must give greater attention to the service role. Education should be…

Assessing Multidimensional Energy Literacy of Secondary Students Using Contextualized Assessment

ERIC Educational Resources Information Center

Chen, Kuan-Li; Liu, Shiang-Yao; Chen, Po-Hsi

2015-01-01

Energy literacy is multidimensional, comprising broad content knowledge as well as affect and behavior. Our previous study has defined four core dimensions for the assessment framework, including energy concepts, reasoning on energy issues, low-carbon lifestyle, and civic responsibility for a sustainable society. The present study compiled a…

Using Regional Distribution of Estuarine and Coastal Benthic Invertebrates to Calibrate Benthic Indices of Ecological Condition

EPA Science Inventory

The biogeography of marine benthic macroinvertebrates of the U.S. Atlantic coast from Delaware Bay north to Passamaquoddy Bay, Maine, was studied to define physical-chemical factors affecting broad taxa distributions and provide information needed to calibrate benthic indices of ...

Government-Funded Students and Courses, 2015. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2016

2016-01-01

This publication provides a summary of 2015 and time-series data relating to students, programs, subjects, training providers and funding in Australia's government-funded vocational education and training (VET) system (broadly defined as all activity delivered by government providers and government-funded activity delivered by community education…

Defining the Role of Academics in Accountability

ERIC Educational Resources Information Center

El-Khawas, Elaine

2009-01-01

The policy debate on accountability in higher education has been vigorous in many countries, but it has focused primarily on broad objectives or approaches. Limited attention has been paid to the mechanisms by which universities would implement accountability objectives and to the critical role of academics in developing ways to assess learning…

An Empirical Study of the Construct Validity of Social Creativity

ERIC Educational Resources Information Center

Mouchiroud, Christophe; Bernoussi, Aurore

2008-01-01

Creativity can be broadly defined as a combination of interacting individual and environmental resources leading to the production of valuable solutions. This paper concentrates on the type of creativity that can be expressed in solving social problems. After reviewing the potentially relevant psychological and contextual variables intervening in…

Financial Information 2015. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2016

2016-01-01

This publication provides information on how government-funded vocational education and training (VET) in Australia is financed and where the money is spent. Government-funded VET in the 2015 reporting year is broadly defined as all activity delivered by government providers and government-funded activity delivered by community education providers…

Camera! Action! Collaborate with Digital Moviemaking

ERIC Educational Resources Information Center

Swan, Kathleen Owings; Hofer, Mark; Levstik, Linda S.

2007-01-01

Broadly defined, digital moviemaking integrates a variety of media (images, sound, text, video, narration) to communicate with an audience. There is near-ubiquitous access to the necessary software (MovieMaker and iMovie are bundled free with their respective operating systems) and hardware (computers with Internet access, digital cameras, etc.).…

Chlorination Disinfection By-Products and Risk of Congenital Anomalies in England and Wales

PubMed Central

Nieuwenhuijsen, Mark J.; Toledano, Mireille B.; Bennett, James; Best, Nicky; Hambly, Peter; de Hoogh, Cornelis; Wellesley, Diana; Boyd, Patricia A.; Abramsky, Lenore; Dattani, Nirupa; Fawell, John; Briggs, David; Jarup, Lars; Elliott, Paul

2008-01-01

Background Increased risk of various congenital anomalies has been reported to be associated with trihalomethane (THM) exposure in the water supply. Objectives We conducted a registry-based study to determine the relationship between THM concentrations and the risk of congenital anomalies in England and Wales. Methods We obtained congenital anomaly data from the National Congenital Anomalies System, regional registries, and the national terminations registry; THM data were obtained from water companies. Total THM (< 30, 30 to < 60, ≥60 μg/L), total brominated exposure (< 10, 10 to < 20, ≥20 μg/L), and bromoform exposure (< 2, 2 to < 4, ≥4 μg/L) were modeled at the place of residence for the first trimester of pregnancy. We included 2,605,226 live births, stillbirths, and terminations with 22,828 cases of congenital anomalies. Analyses using fixed- and random-effects models were performed for broadly defined groups of anomalies (cleft palate/lip, abdominal wall, major cardiac, neural tube, urinary and respiratory defects), a more restricted set of anomalies with better ascertainment, and for isolated and multiple anomalies. Data were adjusted for sex, maternal age, and socioeconomic status. Results We found no statistically significant trends across exposure categories for either the broadly defined or more restricted sets of anomalies. For the restricted set of anomalies with isolated defects, there were significant (p < 0.05) excess risks in the high-exposure categories of total THMs for ventricular septal defects [odds ratio (OR) = 1.43; 95% confidence interval (CI), 1.00–2.04] and of bromoform for major cardiovascular defects and gastroschisis (OR = 1.18; 95% CI, 1.00–1.39; and OR = 1.38; 95% CI, 1.00–1.92, respectively). Conclusion In this large national study we found little evidence for a relationship between THM concentrations in drinking water and risk of congenital anomalies. PMID:18288321

Can We Rule Out Meningitis from Negative Jolt Accentuation? A Retrospective Cohort Study.

PubMed

Sato, Ryota; Kuriyama, Akira; Luthe, Sarah Kyuragi

2017-04-01

Jolt accentuation has been considered to be the most sensitive physical finding to predict meningitis. However, there are only a few studies assessing the diagnostic accuracy of jolt accentuation. Therefore, we aimed to evaluate the diagnostic accuracy of jolt accentuation and investigate whether it can be extended to patients with mild altered mental status. We performed a single center, retrospective observational study on patients who presented to the emergency department in a Japanese tertiary care center from January 1, 2010 to March 31, 2016. Jolt accentuation evaluated in patients with fever, headache, and mild altered mental status with Glasgow Coma Scale no lower than E2 or M4 was defined as "jolt accentuation in the broad sense." Jolt accentuation evaluated in patients with fever, headache, and no altered mental status was defined as "jolt accentuation in the narrow sense." We evaluated the sensitivity and specificity in both groups. Among 118 patients, the sensitivity and specificity of jolt accentuation in the broad sense were 70.7% (95% confidence interval (CI): 58.0%-80.8%) and 36.7% (95% CI: 25.6%-49.3%). The positive likelihood ratio and negative likelihood ratio were 1.12 (95% CI: 0.87-1.44) and 0.80 (95% CI: 0.48-1.34), respectively. Among 108 patients, the sensitivity and specificity of jot accentuation in the narrow sense were 75.0% (95% CI: 61.8%-84.8%) and 35.1% (95% CI: 24.0%-48.0%). The positive likelihood ratio and negative likelihood ratio were 1.16 (95% CI: 0.90-1.48) and 0.71 (95% CI: 0.40-1.28), respectively. Jolt accentuation itself has a limited value in the diagnosis of meningitis regardless of altered mental status. Therefore, meningitis should not be ruled out by negative jolt accentuation. © 2017 American Headache Society.

[The definition of benefits: from the benefit package to the supply of services].

PubMed

Elola Somoza, J

1995-01-01

The definition of a "benefit package" of services covered by the National Health System of Spain--NHSS--raises technical and political problems. This article examines six relevant issues related with the implementation of this strategy: the instrument to define the services covered by the public system; health care expenditures; access to the services; quality; and the decision making-process. The definition of a comprehensive package of--broadly defined--services covered by the NHSS seems to be the most appropriate strategy, instead of a very detailed "catalog" of medical practices.

Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration.

PubMed

Liu, Meng; Yuan, Jie; Hu, Wen-Juan; Ke, Chang-Qiang; Zhang, Yi-Fan; Ye, Yang; Zhong, Da-Fang; Zhao, Guang-Rong; Yao, Sheng; Liu, Jia

2018-05-17

The influence of broad-spectrum antibiotics on the pharmacokinetics and biotransformation of major constituents of Shaoyao-Gancao decoction (SGD) in rats was investigated. The pharmacokinetic behaviors of paeoniflorin (PF), albiflorin (AF), liquiritin (LT), isoliquiritin (ILT), liquiritin apioside (LA), isoliquiritin apioside (ILA), and glycyrrhizic acid (GL), seven major constituents of SGD, as well as glycyrrhetinic acid (GA), a major metabolite of GL, were analyzed. A 1-week pretreatment with broad-spectrum antibiotics (ampicillin, metronidazole, neomycin, 1 g L -1 ; and vancomycin, 0.5 g L -1 ) via drinking water reduced plasma exposure of the major constituents. The AUC 0-24 h of PF and LT was significantly decreased by 28.7% and 33.8% (P < 0.05 and P < 0.005), respectively. Although the differences were not statistically significant, the AUC 0-24 h of AF, ILT, LA, ILA, and GL was decreased by 31.4%, 50.9%, 16.9%, 44.1%, and 37.0%, respectively, compared with the control group. In addition, the plasma GA exposure in the antibiotic-pretreated group was significantly lower (P < 0.005) than the control group. The in vitro stability of the major constituents of SGD in the rat intestinal contents with or without broad-spectrum antibiotics was also investigated. The major constituents were comparatively stable in the rat duodenum contents, and the biotransformation of GL mainly occurred in the rat colon contents. In summary, broad-spectrum antibiotics suppressed the absorption of the major constituents of SGD and significantly inhibited the biotransformation of GL to GA by suppressing the colon microbiota. The results indicated a potential clinical drug-drug interaction (DDI) when SGD was administered with broad-spectrum antibiotics.

42 CFR 435.223 - Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 4 2012-10-01 2012-10-01 false Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad as allowed under title IV-A. 435.223 Section 435.223... plan were as broad as allowed under title IV-A. (a) The agency may provide Medicaid to any group or...

42 CFR 435.223 - Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad as allowed under title IV-A. 435.223 Section 435.223... plan were as broad as allowed under title IV-A. (a) The agency may provide Medicaid to any group or...

42 CFR 435.223 - Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Individuals who would be eligible for AFDC if coverage under the State's AFDC plan were as broad as allowed under title IV-A. 435.223 Section 435.223... plan were as broad as allowed under title IV-A. (a) The agency may provide Medicaid to any group or...

Monitoring community mobilisation and organisational capacity among high-risk groups in a large-scale HIV prevention programme in India: selected findings using a Community Ownership and Preparedness Index.

PubMed

Narayanan, Pradeep; Moulasha, K; Wheeler, Tisha; Baer, James; Bharadwaj, Sowmyaa; Ramanathan, T V; Thomas, Tom

2012-10-01

In a participatory approach to health and development interventions, defining and measuring community mobilisation is important, but it is challenging to do this effectively, especially at scale. A cross-sectional, participatory monitoring tool was administered in 2008-2009 and 2009-2010 across a representative sample of 25 community-based groups (CBGs) formed under the Avahan India AIDS Initiative, to assess their progress in mobilisation, and to inform efforts to strengthen the groups and make them sustainable. The survey used a weighted index to capture both qualitative and quantitative data in numeric form. The index permitted broad, as well as highly detailed, analysis of community mobilisation, relevant at the level of individual groups, as well as state-wide and across the whole programme. The survey demonstrated that leadership and programme management were the strongest areas among the CBGs, confirming the programme's investment in these areas. Discussion of the Round 1 results led to efforts to strengthen governance and democratic decision making in the groups, and progress was reflected in the Round 2 survey results. CBG engagement with state authorities to gain rights and entitlements and securing the long-term financial stability of groups remain a challenge. The survey has proven useful for informing the managers of programmes about what is happening on the ground, and it has opened spaces for discussion within community groups about the nature of leadership, decision making and their goals, which is leading to accelerated progress. The tool provided useful data to manage community mobilisation in Avahan.

Analysis of a human phenomenon: self-concept.

PubMed

LeMone, P

1991-01-01

This analysis of self-concept includes an examination of definitions, historical perspectives, theoretical basis, and closely related terms. Antecedents, consequences, defining attributes, and a definition were formulated based on the analysis. The purpose of the analysis was to provide support for the use of the label "self-concept" as a broad category that encompasses the self-esteem, identity, and body-image nursing diagnoses within Taxonomy I. This classification could allow the use of a broad diagnostic label to better describe conditions that necessitate nursing care. It may also further explain the relationships between and among those diagnoses that describe human responses to disturbance of any component of the self-concept.

Diversity and dialogue in immunity to helminths.

PubMed

Allen, Judith E; Maizels, Rick M

2011-06-01

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.

The Creation of a Pediatric Hospital Medicine Dashboard: Performance Assessment for Improvement.

PubMed

Fox, Lindsay Anne; Walsh, Kathleen E; Schainker, Elisabeth G

2016-07-01

Leaders of pediatric hospital medicine (PHM) recommended a clinical dashboard to monitor clinical practice and make improvements. To date, however, no programs report implementing a dashboard including the proposed broad range of metrics across multiple sites. We sought to (1) develop and populate a clinical dashboard to demonstrate productivity, quality, group sustainability, and value added for an academic division of PHM across 4 inpatient sites; (2) share dashboard data with division members and administrations to improve performance and guide program development; and (3) revise the dashboard to optimize its utility. Division members proposed a dashboard based on PHM recommendations. We assessed feasibility of data collection and defined and modified metrics to enable collection of comparable data across sites. We gathered data and shared the results with division members and administrations. We collected quarterly and annual data from October 2011 to September 2013. We found comparable metrics across all sites for descriptive, productivity, group sustainability, and value-added domains; only 72% of all quality metrics were tracked in a comparable fashion. After sharing the data, we saw increased timeliness of nursery discharges and an increase in hospital committee participation and grant funding. PHM dashboards have the potential to guide program development, mobilize faculty to improve care, and demonstrate program value to stakeholders. Dashboard implementation at other institutions and data sharing across sites may help to better define and strengthen the field of PHM by creating benchmarks and help improve the quality of pediatric hospital care. Copyright © 2016 by the American Academy of Pediatrics.

Contemporary Business Administration Curricula

ERIC Educational Resources Information Center

Gleason, James R.

2006-01-01

The National Association of State Directors of Career Technical Education Consortium (NASDCTEc) career clusters initiative was designed to research and foster development of curicula and assessments for each of 16 broad occupational groupings known as career clusters. These clusters encompass a broad range of careers, ranging from agriculture to…

Ethno-Racial Variation in Recovery From Severe Mental Illness: A Qualitative Comparison.

PubMed

Whitley, Rob

2016-06-01

Purpose-driven studies examining the relationship between ethnicity, culture, and recovery are absent from the empirical literature. As such, the overall aim of this study was to examine ethno-racial variations in recovery perspectives. Specific objectives consist of comparing and contrasting ethno-racial variations in 1) definitions of recovery, 2) barriers to recovery, and 3) facilitators of recovery. We recruited people with severe mental illness from 2 broad ethno-racial groups (Caribbean-Canadian and Euro-Canadian) to partake in a qualitative interview on recovery (n = 47). Participants were asked to give their own definitions of recovery, as well as self-perceived barriers and facilitators. Interview transcripts were then subjected to thematic analysis. We compared and contrasted the distribution and salience of emerging themes between the Euro-Canadian and Caribbean-Canadian participants. Recovery was consistently defined as a gradual process involving progress in key life domains including employment, social engagement, and community participation by both groups. This was underpinned by a growing future orientation. Stigma, financial strain, and psychiatric hospitalization were considered major barriers to recovery in both groups. Participants from both groups generally considered stated definitions of recovery to be simultaneous facilitators of recovery-employment and social engagement being the most frequently mentioned. God and religion were key facilitators for the Caribbean-Canadian group but not for Euro-Canadians. Definitions, barriers, and facilitators to recovery were generally shared among our sample, regardless of ethno-racial status, with the exception of God and religion. © The Author(s) 2016.

Stuck in the catch 22: attitudes towards smoking cessation among populations vulnerable to social disadvantage.

PubMed

Pateman, Kelsey; Ford, Pauline; Fizgerald, Lisa; Mutch, Allyson; Yuke, Kym; Bonevski, Billie; Gartner, Coral

2016-06-01

To explore how smoking and smoking cessation is perceived within the context of disadvantage, across a broad cross-section of defined populations vulnerable to social disadvantage. Qualitative focus groups with participants recruited through community service organizations (CSO). Metropolitan and regional settings in Queensland, Australia. Focus groups were held at the respective CSO facilities. Fifty-six participants across nine focus groups, including people living with mental illness, people experiencing or at risk of homelessness (adult and youth populations), people living with HIV, people living in a low-income area and Indigenous Australians. Thematic, in-depth analysis of focus group discussions. Participant demographic information and smoking history was recorded. Smoking behaviour, smoking identity and feelings about smoking were reflective of individual circumstances and social and environmental context. Participants felt 'trapped' in smoking because they felt unable to control the stressful life circumstances that triggered and sustained their smoking. Smoking cessation was viewed as an individual's responsibility, which was at odds with participants' statements about the broader factors outside of their own control that were responsible for their smoking. Highly disadvantaged smokers' views on smoking involve contradictions between feeling that smoking cessation involves personal responsibility, while at the same time feeling trapped by stressful life circumstances. Tobacco control programmes aiming to reduce smoking among disadvantaged groups are unlikely to be successful unless the complex interplay of social factors is carefully considered. © 2015 Society for the Study of Addiction.

The meaning of numbers in health: exploring health numeracy in a Mexican-American population.

PubMed

Schapira, Marilyn M; Fletcher, Kathlyn E; Ganschow, Pamela S; Walker, Cindy M; Tyler, Bruce; Del Pozo, Sam; Schauer, Carrie; Jacobs, Elizabeth A

2011-07-01

Health numeracy can be defined as the ability to use numeric information in the context of health. The interpretation and application of numbers in health may vary across cultural groups. To explore the construct of health numeracy among persons who identify as Mexican American. Qualitative focus group study. Groups were stratified by preferred language and level of education. Audio-recordings were transcribed and Spanish groups (n = 3) translated to English. An analysis was conducted using principles of grounded theory. A purposeful sample of participants from clinical and community sites in the Milwaukee and Chicago metropolitan areas. A theoretical framework of health numeracy was developed based upon categories and major themes that emerged from the analysis. Six focus groups were conducted with 50 participants. Initial agreement in coding was 59-67% with 100% reached after reconciliation by the coding team. Three major themes emerged: 1) numeracy skills are applied to a broad range of communication and decision making tasks in health, 2) affective and cognitive responses to numeric information influence use of numbers in the health setting, and 3) there exists a strong desire to understand the meaning behind numbers used in health. The findings informed a theoretical framework of health numeracy. Numbers are important across a range of skills and applications in health in a sample of an urban Mexican-American population. This study expands previous work that strives to understand the application of numeric skills to medical decision making and health behaviors.

Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004

PubMed Central

Coco, Andrew S; Horst, Michael A; Gambler, Angela S

2009-01-01

Background Overuse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown. Methods Analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 1998 to 2004 (N = 6,878). Setting is office-based physicians, hospital outpatient departments, and emergency departments. Patients are children aged 12 years and younger prescribed antibiotics for acute otitis media. Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones. Results Broad-spectrum prescribing for acute otitis media increased from 34% of visits in 1998 to 45% of visits in 2004 (P < .001 for trend). The trend was primarily attributable to an increase in prescribing of amoxicillin/clavulanate (8% to 15%; P < .001 for trend) and macrolides (9% to 15%; P < .001 for trend). Prescribing remained stable for amoxicillin and cephalosporins while decreasing for narrow-spectrum agents (12% to 3%; P < .001 for trend) over the study period. Independent predictors of broad-spectrum antibiotic prescribing were ear pain, non-white race, public and other insurance (compared to private), hospital outpatient department setting, emergency department setting, and West region (compared to South and Midwest regions), each of which was associated with lower rates of broad-spectrum prescribing. Age and fever were not associated with prescribing choice. Conclusion Prescribing of broad-spectrum antibiotics for acute otitis media has steadily increased from 1998 to 2004. Associations with non-clinical factors suggest potential for improvement in prescribing practice. PMID:19552819

Geographical Gradients in Argentinean Terrestrial Mammal Species Richness and Their Environmental Correlates

PubMed Central

Márquez, Ana L.; Real, Raimundo; Kin, Marta S.; Guerrero, José Carlos; Galván, Betina; Barbosa, A. Márcia; Olivero, Jesús; Palomo, L. Javier; Vargas, J. Mario; Justo, Enrique

2012-01-01

We analysed the main geographical trends of terrestrial mammal species richness (SR) in Argentina, assessing how broad-scale environmental variation (defined by climatic and topographic variables) and the spatial form of the country (defined by spatial filters based on spatial eigenvector mapping (SEVM)) influence the kinds and the numbers of mammal species along these geographical trends. We also evaluated if there are pure geographical trends not accounted for by the environmental or spatial factors. The environmental variables and spatial filters that simultaneously correlated with the geographical variables and SR were considered potential causes of the geographic trends. We performed partial correlations between SR and the geographical variables, maintaining the selected explanatory variables statistically constant, to determine if SR was fully explained by them or if a significant residual geographic pattern remained. All groups and subgroups presented a latitudinal gradient not attributable to the spatial form of the country. Most of these trends were not explained by climate. We used a variation partitioning procedure to quantify the pure geographic trend (PGT) that remained unaccounted for. The PGT was larger for latitudinal than for longitudinal gradients. This suggests that historical or purely geographical causes may also be relevant drivers of these geographical gradients in mammal diversity. PMID:23028254

Chemical Space Mapping and Structure-Activity Analysis of the ChEMBL Antiviral Compound Set.

PubMed

Klimenko, Kyrylo; Marcou, Gilles; Horvath, Dragos; Varnek, Alexandre

2016-08-22

Curation, standardization and data fusion of the antiviral information present in the ChEMBL public database led to the definition of a robust data set, providing an association of antiviral compounds to seven broadly defined antiviral activity classes. Generative topographic mapping (GTM) subjected to evolutionary tuning was then used to produce maps of the antiviral chemical space, providing an optimal separation of compound families associated with the different antiviral classes. The ability to pinpoint the specific spots occupied (responsibility patterns) on a map by various classes of antiviral compounds opened the way for a GTM-supported search for privileged structural motifs, typical for each antiviral class. The privileged locations of antiviral classes were analyzed in order to highlight underlying privileged common structural motifs. Unlike in classical medicinal chemistry, where privileged structures are, almost always, predefined scaffolds, privileged structural motif detection based on GTM responsibility patterns has the decisive advantage of being able to automatically capture the nature ("resolution detail"-scaffold, detailed substructure, pharmacophore pattern, etc.) of the relevant structural motifs. Responsibility patterns were found to represent underlying structural motifs of various natures-from very fuzzy (groups of various "interchangeable" similar scaffolds), to the classical scenario in medicinal chemistry (underlying motif actually being the scaffold), to very precisely defined motifs (specifically substituted scaffolds).

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis

PubMed Central

Ahmed, Mustafa Y.; Al-Khayat, Aisha; Al-Murshedi, Fathiya; Al-Futaisi, Amna; Chioza, Barry A.; Pedro Fernandez-Murray, J.; Self, Jay E.; Salter, Claire G.; Harlalka, Gaurav V.; Rawlins, Lettie E.; Al-Zuhaibi, Sana; Al-Azri, Faisal; Al-Rashdi, Fatma; Cazenave-Gassiot, Amaury; Wenk, Markus R.; Al-Salmi, Fatema; Patton, Michael A.; Silver, David L.; Baple, Emma L.; McMaster, Christopher R.; Crosby, Andrew H.

2017-01-01

Abstract Mutations in genes involved in lipid metabolism have increasingly been associated with various subtypes of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative motor neuron disorders characterized by spastic paraparesis. Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine. Phosphatidylethanolamine is a glycerophospholipid that, together with phosphatidylcholine, constitutes more than half of the total phospholipids in eukaryotic cell membranes. We determined that the mutation defined dramatically reduces the enzymatic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine synthesis. Additionally, due to central nervous system inaccessibility we undertook quantification of phosphatidylethanolamine levels and species in patient and control blood samples as an indication of liver phosphatidylethanolamine biosynthesis. Although this revealed alteration to levels of specific phosphatidylethanolamine fatty acyl species in patients, overall phosphatidylethanolamine levels were broadly unaffected indicating that in blood EPT1 inactivity may be compensated for, in part, via alternate biochemical pathways. These studies define the first human disorder arising due to defective CDP-ethanolamine biosynthesis and provide new insight into the role of Kennedy pathway components in human neurological function. PMID:28052917

Chemocoding as an identification tool where morphological- and DNA-based methods fall short: Inga as a case study.

PubMed

Endara, María-José; Coley, Phyllis D; Wiggins, Natasha L; Forrister, Dale L; Younkin, Gordon C; Nicholls, James A; Pennington, R Toby; Dexter, Kyle G; Kidner, Catherine A; Stone, Graham N; Kursar, Thomas A

2018-04-01

The need for species identification and taxonomic discovery has led to the development of innovative technologies for large-scale plant identification. DNA barcoding has been useful, but fails to distinguish among many species in species-rich plant genera, particularly in tropical regions. Here, we show that chemical fingerprinting, or 'chemocoding', has great potential for plant identification in challenging tropical biomes. Using untargeted metabolomics in combination with multivariate analysis, we constructed species-level fingerprints, which we define as chemocoding. We evaluated the utility of chemocoding with species that were defined morphologically and subject to next-generation DNA sequencing in the diverse and recently radiated neotropical genus Inga (Leguminosae), both at single study sites and across broad geographic scales. Our results show that chemocoding is a robust method for distinguishing morphologically similar species at a single site and for identifying widespread species across continental-scale ranges. Given that species are the fundamental unit of analysis for conservation and biodiversity research, the development of accurate identification methods is essential. We suggest that chemocoding will be a valuable additional source of data for a quick identification of plants, especially for groups where other methods fall short. © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Asian Monsoons: Variability, Predictability, and Sensitivity to External Forcing

NASA Technical Reports Server (NTRS)

Yang, Song; Lau, K.-M.; Kim, K.-M.

1999-01-01

In this study, we have addressed the interannual variations of Asian monsoons including both broad-scale and regional monsoon components. Particular attention is devoted to the identities of the South China Sea monsoon and Indian monsoon. We use CPC Merged Analysis of Precipitation and NCEP reanalyses to define regional monsoon indices and to depict the various monsoons. Parallel modeling studies have also been carried out to assess the potential predictability of the broad-scale and regional monsoons. Each monsoon is characterized by its unique features. While the South Asian monsoon represents a classical monsoon in which anomalous circulation is governed by Rossby-wave dynamics, the Southeast Asian monsoon symbolizes a "hybrid" monsoon that features multi-cellular meridional circulation over eastern Asia. The broad-scale Asian monsoon links to the basin-wide atmospheric circulation over the Indian-Pacific oceans. Both Sea Surface Temperatures (SST) and land surface processes are important for determining the variations of all monsoons. For the broad-scale monsoon, SST anomalies are more important than land surface processes. However, for regional monsoons, land surface processes may become equally important. Both observation and model shows that the broad-scale monsoon is potentially more predictable than regional monsoons, and that the Southeast Asian monsoon may possess higher predictability than the South Asian monsoon.

Economic Incentives for Cybersecurity: Using Economics to Design Technologies Ready for Deployment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vishik, Claire; Sheldon, Frederick T; Ott, David

Cybersecurity practice lags behind cyber technology achievements. Solutions designed to address many problems may and do exist but frequently cannot be broadly deployed due to economic constraints. Whereas security economics focuses on the cost/benefit analysis and supply/demand, we believe that more sophisticated theoretical approaches, such as economic modeling, rarely utilized, would derive greater societal benefits. Unfortunately, today technologists pursuing interesting and elegant solutions have little knowledge of the feasibility for broad deployment of their results and cannot anticipate the influences of other technologies, existing infrastructure, and technology evolution, nor bring the solutions lifecycle into the equation. Additionally, potentially viable solutionsmore » are not adopted because the risk perceptions by potential providers and users far outweighs the economic incentives to support introduction/adoption of new best practices and technologies that are not well enough defined. In some cases, there is no alignment with redominant and future business models as well as regulatory and policy requirements. This paper provides an overview of the economics of security, reviewing work that helped to define economic models for the Internet economy from the 1990s. We bring forward examples of potential use of theoretical economics in defining metrics for emerging technology areas, positioning infrastructure investment, and building real-time response capability as part of software development. These diverse examples help us understand the gaps in current research. Filling these gaps will be instrumental for defining viable economic incentives, economic policies, regulations as well as early-stage technology development approaches, that can speed up commercialization and deployment of new technologies in cybersecurity.« less

English and the Knowledge Economy: A Critical Analysis

ERIC Educational Resources Information Center

Collin, Ross

2014-01-01

This article focuses on knowledge economy discourse and considers the appeal of this discourse to English educators. Knowledge economy discourse is defined as a mode of thought and expression that assumes a broad-based economy driven by innovation will soon emerge in the USA. This discourse, it is argued, offers English teachers solutions to some…

Environmental Values related to fish and wildlife lands

Treesearch

David N. Bengston

2000-01-01

THe purpose of this paper is to provide an overview of key concepts related to environmental values and their importance for public land managers. The following section defines environmental values and discusses their relationship to environmnetal attitudes and beliefs. This is followed by presentation of a broad system for classifying environmental values and...

Guiding Neuronal Growth in Tissues with Light

DTIC Science & Technology

2010-02-27

and structural properties of their surroundings in addition to the biochemical properties. Furthermore, three-dimensional biopolymer matrices provide...Properties of Biopolymer Networks Biopolymer networks exhibit unique nonlinear rheological behavior that differs dramatically from most synthetic...and presumably other biopolymers , is not well defined in variable gap geometries. These findings have broad implications for the interpretation of

Making Meaning of Inclusive Education: Classroom Practices in Finnish and South African Classrooms

ERIC Educational Resources Information Center

Engelbrecht, Petra; Savolainen, Hannu; Nel, Mirna; Koskela, Teija; Okkolin, Mari-Anne

2017-01-01

This paper reports on the findings of an international comparative research project where the roles of teachers in the implementation of inclusive education in mainstream-classroom settings in South Africa and Finland were investigated. Inclusive education within this project is broadly defined as welcoming all students to general-education…

78 FR 13157 - Recruitment Notice for the Taxpayer Advocacy Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... issues that affect taxpayers, and make suggestions for improving IRS service and customer satisfaction... year, and a desire to help improve IRS customer service. To the extent possible, the TAP Director will... taxpayers'' are broadly defined to include U.S. citizens working, living, or doing business abroad or in a U...

Experiment, monitoring, and gradient methods used to infer climate change effects on plant communities yield consistent patterns

Treesearch

Sarah C. Elmendorf; Gregory H.R. Henry; Robert D. Hollisterd; Anna Maria Fosaa; William A. Gould; Luise Hermanutz; Annika Hofgaard; Ingibjorg I. Jonsdottir; Janet C. Jorgenson; Esther Levesque; Borgbor Magnusson; Ulf Molau; Isla H. Myers-Smith; Steven F. Oberbauer; Christian Rixen; Craig E. Tweedie; Marilyn Walkers

2015-01-01

Inference about future climate change impacts typically relies on one of three approaches: manipulative experiments, historical comparisons (broadly defined to include monitoring the response to ambient climate fluctuations using repeat sampling of plots, dendroecology, and paleoecology techniques), and space-for-time substitutions derived from sampling along...

School-Based Early Childhood Centers: Secrets of Success from Early Innovators.

ERIC Educational Resources Information Center

Jewett, Janet L.; Katzev, Aphra

School-based early childhood centers have the potential for responding effectively to a broad range of child and family needs and to society's demands for more effective schools. They have four defining features: (1) implementation of quality programs and developmentally appropriate practices for young children through age eight; (2) families as…

Loss of Language in Early Development of Autism and Specific Language Impairment

ERIC Educational Resources Information Center

Pickles, Andrew; Simonoff, Emily; Conti-Ramsden, Gina; Falcaro, Milena; Simkin, Zoe; Charman, Tony; Chandler, Susie; Loucas, Tom; Baird, Gillian

2009-01-01

Background: Several authors have highlighted areas of overlap in symptoms and impairment among children with autism spectrum disorder (ASD) and children with specific language impairment (SLI). By contrast, loss of language and broadly defined regression have been reported as relatively specific to autism. We compare the incidence of language loss…

Job Sharing: An Alternative to Traditional Employment Patterns.

ERIC Educational Resources Information Center

Duttweiler, Robert W.

Taking the view that job sharing is a positive alternative for workers and employers, this article defines job sharing in broad terms and describes its evolution from the Fair Labor Standards Act of 1938 to the present. The advantages, such as increased productivity, are felt to be impressive, but disadvantages also exist, including significant…

Does an Ability to Pattern Indicate That Our Thinking Is Mathematical?

ERIC Educational Resources Information Center

McCluskey, Catherine; Mitchelmore, Michael; Mulligan, Joanne

2013-01-01

Research affirms that pattern and structure underlie the development of a broad range of mathematical concepts. However, the concept of pattern also occurs in other fields. This theoretical paper explores pattern recognition, a neurological construct based on the world of Goldberg (2005), and pattern as defined in the field of mathematics to…

Estimating the Reliability of Dichotomous or Trichotomous Scores

ERIC Educational Resources Information Center

Feldt, Leonard S.

2005-01-01

To meet the requirements of the No Child Left Behind Act, school districts and states must compile summary reports of the levels of student achievement in reading and mathematics. The levels are to be described in broad categories: "basic and below," "proficient," or "advanced." Educational units are given considerable latitude in defining the…

Pursuing Information: A Conversation Analytic Perspective on Communication Strategies

ERIC Educational Resources Information Center

Burch, Alfred R.

2014-01-01

Research on second language (L2) communication strategies over the past three decades has concerned itself broadly with defining their usage in terms of planning and compensation, as well as with the use of taxonomies for coding different types of strategies. Taking a Conversation Analytic (CA) perspective, this article examines the fine-grained…

An Examination of the Construct Validity of the Inventory of Classroom Management Style.

ERIC Educational Resources Information Center

Martin, Nancy K.; Baldwin, Beatrice

Confirmatory factor analysis was used to examine the construct validity of a new instrument measuring perceptions toward classroom management: the Inventory of Classroom Management Style (ICMS). Classroom management was defined as a multifaceted process that includes three broad dimensions: (1) what teachers believe about students as persons; (2)…

Asian Pentecostalism: A Religion Whose Only Limit Is the Sky

ERIC Educational Resources Information Center

Ma, Wonsuk

2004-01-01

The study surveys the current growth of Pentecostal Christianity, as defined broadly, in Asia, particularly in comparison with Latin America and Africa, predicting that the future growth is expected to be exponential. In a brief historical survey, the continent is divided into four categories depending on the beginning and development of…

International Financial Institution Policies of Conditionality and Public Pedagogy

ERIC Educational Resources Information Center

MacPhail, Scott; McGray, Robert

2014-01-01

Conditionalities are most broadly defined as the provisos that are to be met by a country when borrowing money from the International Financial Institutions (IFIs). Increasingly, they have proven to have far reaching consequences for countries entering into agreements with The World Bank, the International Monetary Fund, and the World Trade…

The Most Important of All the Organs: Darwin on the Brain

ERIC Educational Resources Information Center

Jacyna, Stephen

2009-01-01

This article discusses Charles Darwin's interest in topics that may broadly be defined as "neurological" in character. Using published and manuscript materials, it examines the sources of Darwin's knowledge of neurological matters and seeks to explain why questions concerning the relation of mind and brain both in humans and other animals were…

77 FR 17143 - Medicaid Program; Eligiblity Changes Under the Affordable Care Act of 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... Medicaid coverage of pregnant women and only cover services related to pregnancy or to other conditions which may complicate pregnancy (hereinafter referred to as ``pregnancy-related services'') for pregnant... pregnancy-related services, but that we amend Sec. 440.210(a)(2) to broadly define ``pregnancy-related...

Why Professors Hate Their Jobs: A Critique of the Pedagogy of Academic Disengagement

ERIC Educational Resources Information Center

Parsons, Jim; Frick, William

2008-01-01

(Purpose) The purpose of this study was to explore reasons why many academics "hate" their jobs by examining the current state of the academy--its values, culture, and possibilities. (Methodology) Through pragmatic and philosophical argument, the authors contend that the academy fosters a pedagogy (defined broadly) of disengagement, and…

Land and Liberty: The Ordinances of the 1780s.

ERIC Educational Resources Information Center

Sheehan, Bernard W.

The U.S. Constitution established the broad legal frame for the U.S. political order; the ordinances provided the indispensable means for the expansion of that order across the continent. The first effort at organizing the northwest occurred in 1784. Written by Thomas Jefferson, the Ordinance of 1784 defined the stages through which territories…

Rotating Solids and Flipping Instruction

ERIC Educational Resources Information Center

Grypp, Lynette; Luebeck, Jennifer

2015-01-01

Technology is causing educators to rethink the entire notion of classroom learning, not only with respect to what learning should take place but also where it should take place. One such innovation is flipped instruction, broadly defined by Staker and Horn (2012) as an instructional model in which students learn partly through online delivery and…

Defining Mental Illness: The Relationship between College Students' Beliefs about the Definition of Mental Illness and Tolerance.

ERIC Educational Resources Information Center

Granello, Darcy Haag; Granello, Paul F.

2000-01-01

Investigates the relationship between college undergraduate students' (N=102) beliefs about the definition of mental illness and their tolerance toward individuals with mental illnesses. Results show that students with broad and inclusive definitions of mental illness had more benevolent, less authoritarian, and less socially restrictive attitudes…

Educational Struggles and Citizenship Education. The Case of Poland

ERIC Educational Resources Information Center

Popow, Monika; Sáez-Rosenkranz, Isidora

2016-01-01

The aim of the paper is to analyse the relation between educational struggles and citizenship education in contemporary Poland. It adopts the critical pedagogy perspective and broadly defines the concept of educational struggle as struggling over the content of education, as social tensions in the field of education, as well as the students' and…

Computational Thinking in Elementary and Secondary Teacher Education

ERIC Educational Resources Information Center

Yadav, Aman; Mayfield, Chris; Zhou, Ninger; Hambrusch, Susanne; Korb, John T.

2014-01-01

Computational thinking (CT) is broadly defined as the mental activity for abstracting problems and formulating solutions that can be automated. In an increasingly information-based society, CT is becoming an essential skill for everyone. To ensure that students develop this ability at the K-12 level, it is important to provide teachers with an…

Redesign of Library Workflows: Experimental Models for Electronic Resource Description.

ERIC Educational Resources Information Center

Calhoun, Karen

This paper explores the potential for and progress of a gradual transition from a highly centralized model for cataloging to an iterative, collaborative, and broadly distributed model for electronic resource description. The purpose is to alert library managers to some experiments underway and to help them conceptualize new methods for defining,…

Diana's Eulogy: Breaking New Ground in Epideictic Rhetoric?

ERIC Educational Resources Information Center

Scott, David K.

A speech in response to an individual's death is by nature a recurring form of rhetoric. Based on audience expectations and needs, certain generic aspects have emerged to characterize eulogies. The funeral oration has generally been recognized as a form of epideictic rhetoric. Modern scholars have generally broadly defined epideictic rhetoric to…

Optimizing continuous cover forest management. Chapter 6.

Treesearch

Kari Hyytiäinen; Robert G. Haight

2012-01-01

The practice of silviculture involves the art and science of controlling the establishment, growth, composition, health, and quality of forests and woodlands to meet the diverse needs and values of landowners and society on a sustainable basis. Silvicultural practices are often divided into two broadly defined management systems, which in North America are usually...

Reinventing Career Education and Recruitment in Agricultural Education for the 21st Century.

ERIC Educational Resources Information Center

Conroy, Carol A.

2000-01-01

Only 30 of 365 rural middle school students in New York identified traditional agricultural careers as ideal jobs. However, 170 additional students identified areas of interest in the more broadly defined industry of agriculture, food, fiber, and natural resources. Reclassification of occupations using the industry concept was recommended. (SK)

Measuring Active Citizenship through the Development of a Composite Indicator

ERIC Educational Resources Information Center

Hoskins, Bryony L.; Mascherini, Massimiliano

2009-01-01

This article defines Active Citizenship within a European context as a broad range of value based participation. It develops a framework for measuring this phenomenon which combines the four dimensions of Protest and Social Change, Community Life, Representative Democracy and Democratic values. The European Social Survey 2002 is used to populate…

Time Use Patterns between Maintenance, Subsistence and Leisure Activities: A Case Study in China

ERIC Educational Resources Information Center

Hui-fen, Zhou; Zhen-shan, Li; Dong-qian, Xue; Yang, Lei

2012-01-01

The Chinese government conducted its first time use survey of the activities of Chinese individuals in 2008. Activities were classified into three broad types, maintenance activities, subsistence activities and leisure activities. Time use patterns were defined by an individuals' time spent on maintenance, subsistence and leisure activities each…

Durability of wood-plastic composites

Treesearch

J.J. Morrell; Nicole M. Stark; David E. Pendleton; Armando G. McDonald

2006-01-01

Deterioration is broadly defined as any negative effect on the properties of a material. The effects can be due to biological attack or to various non-living agents (sunlight, moisture, temperature), but often, deterioration results from a combination of factors. Nowhere is this more evident than with WPCs, owing to the marriage of dissimilar materials. This article...

The Development of Scientific Thinking Skills in Elementary and Middle School

ERIC Educational Resources Information Center

Zimmerman, Corinne

2007-01-01

The goal of this article is to provide an integrative review of research that has been conducted on the development of children's scientific reasoning. Broadly defined, scientific thinking includes the skills involved in inquiry, experimentation, evidence evaluation, and inference that are done in the service of "conceptual change" or scientific…

China’s Arrival: A Strategic Framework for a Global Relationship

DTIC Science & Technology

2009-09-01

in areas like tourism , even as it broadly strengthens diplomatic and economic ties with many of these small and seemingly obscure island nations...agenda — because they are in the process of defining, as does the United States, good gover - nance and rule of law within countries as sources of

Telemedicine for Access to Quality Care on Medical Practice and Continuing Medical Education in a Global Arena

ERIC Educational Resources Information Center

Rafiq, Azhar; Merrell, Ronald C.

2005-01-01

Health care practices continue to evolve with technological advances integrating computer applications and patient information management into telemedicine systems. Telemedicine can be broadly defined as the use of information technology to provide patient care and share clinical information from one geographic location to another. Telemedicine…

Gatekeeper Training in Campus Suicide Prevention

ERIC Educational Resources Information Center

Wallack, Cory; Servaty-Seib, Heather L.; Taub, Deborah J.

2013-01-01

Gatekeeper training is one of the most commonly employed methods for identifying and intervening with at-risk students (Davidson and Locke, 2010). Within the context of campus suicide prevention, a gatekeeper is broadly defined as any individual who has the potential to come into contact with at-risk students (Davidson and Locke, 2010). Although…

Peer Education in Campus Suicide Prevention

ERIC Educational Resources Information Center

Catanzarite, Julie A.; Robinson, Myles D.

2013-01-01

Student peer educators have been used by higher education intuitions to influence the education and retention of college students for many years, and most institutions have some type of peer educator program. Newton and Ender (2010) broadly define the role of peer educators as "students who have been selected, trained, and designated by a…

Examining Teachers' Perceptions of Social-Emotional and Behavioral Referral Concerns

ERIC Educational Resources Information Center

Briesch, Amy M.; Ferguson, Tyler D.; Volpe, Robert J.; Briesch, Jacquelyn M.

2013-01-01

Although a number of empirical studies have investigated the nature of school-based referrals, predominant focus has been on referrals for psychoeducational evaluation, and social-emotional and behavioral concerns have typically been too broadly defined to provide insight into the specific problems encountered. This study aimed to identify the…

Exploring the Use of Focused Freewriting in Developing Academic Writing

ERIC Educational Resources Information Center

Li, Linda Y.

2007-01-01

Focused freewriting, broadly defined as writing without stopping and editing about a specific topic, has been viewed and used as a powerful tool for developing student writing in a wide spectrum of educational contexts. This study aimed to further explore the use of focused freewriting in the context of promoting students' academic skills…

Government-Funded Student Outcomes, 2016: Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2016

2016-01-01

This publication provides a summary of the outcomes of students who completed government-funded vocational education and training (VET) during 2015, with the data collected in mid-2016. Government-funded VET is broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and…

Government-Funded Students and Courses--January to June 2016. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2016

2016-01-01

This publication provides a summary of data relating to students, programs, subjects, and training providers in Australia's government-funded vocational education and training (VET) system. This is broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and other registered…

Government-Funded Students and Courses: January to March 2015. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2015

2015-01-01

This publication provides a summary of data relating to students, programs, training providers, and funding in Australia's government-funded vocational education and training (VET) system (broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and other registered…

Text Complexity and Young Adult Literature: Establishing Its Place

ERIC Educational Resources Information Center

Glaus, Marci

2014-01-01

Preparing students for college and careers in the 21st century has shed light on text complexity as an important variable for consideration in English Language Arts. Authors of The Common Core State Standards (CCSS) define text complexity as broad, highlighting qualitative, rather than quantitative evaluations of narrative fiction as appropriate…

International Workforce Initiatives: Definitions, Design Options, and Project Profiles. Working Paper Series. No. 1

ERIC Educational Resources Information Center

Wright, J.W., Jr.

2010-01-01

This publication is intended for three primary audiences: international development professionals who want to define "workforce" for program design purposes, those who seek information about field activities, and those who want to reflect on the implementation of successful, high impact programs--whether they were broad-based or…

Over a Half-Century Encapsulated: A Multicultural Content Analysis of the "Journal of Counseling Psychology," 1954-2009

ERIC Educational Resources Information Center

Lee, Debbiesiu L.; Rosen, Adam D.; Burns, Victoria

2013-01-01

Articles including multicultural content published in the "Journal of Counseling Psychology" ("JCP"), from 1954 to 2009, were examined for themes. Multicultural content in this study was broadly defined to include the following identities: race/ethnicity, gender/sex, religion/spirituality, sexual orientation, social status, disability, age, and…

New Directions for Biosciences Research in Agriculture. High-Reward Opportunities.

ERIC Educational Resources Information Center

National Academy of Sciences - National Research Council, Washington, DC. Board on Agriculture.

To aid in the effort to define comprehensive long-range planning goals in bioregulation, the Agricultural Research Service (ARS) asked the Board of Agriculture of the National Research Council to undertake a study of the ARS research programs concerned with bioregulation. (For the purposes of this study bioregulation was interpreted broadly to be…

Taking a Societal Sector Perspective on Youth Learning and Development

ERIC Educational Resources Information Center

McLaughlin, Milbrey; London, Rebecca A.

2013-01-01

A societal sector perspective looks to a broad array of actors and agencies responsible for creating the community contexts that affect youth learning and development. We demonstrate the efficacy of this perspective by describing the Youth Data Archive, which allows community partners to define issues affecting youth that transcend specific…

Defining Quality in Undergraduate Education: Directions for Future Research Informed by a Literature Review

ERIC Educational Resources Information Center

Bowers, Alison W.; Ranganathan, Shyam; Simmons, Denise R.

2018-01-01

Objectives: This research brief explores the literature addressing quality in undergraduate education to identify what previous research has said about quality and to offer future directions for research on quality in undergraduate education. Method: We conducted a scoping review to provide a broad overview of existing research. Using targeted…

The Development and Testing of an Obsessive-Compulsive Personality Instrument.

ERIC Educational Resources Information Center

Bailey, James R.; And Others

Compulsivity and obsessiveness are vaguely defined terms which include a broad range of behaviors and cognitions that have been elusive to quantify. To introduce the 22-item Obsessive-Compulsive Scale (OCS) and to perform preliminary validation studies, 114 (46 male, 68 female) college students and 57 counseling clients completed the OCS on two…

Learner Identities in the Context of Undergraduates: A Case Study

ERIC Educational Resources Information Center

Lawson, Alison

2014-01-01

Background: A "learner identity" can be broadly defined as how an individual feels about himself/herself as a learner and the extent to which he/she describes himself/herself as a "learner." The literature suggests that those from non-traditional backgrounds may struggle to adapt to a university environment with all its related…

Age-Related Progressions in Story Structure in Young Children's Narratives

ERIC Educational Resources Information Center

Khan, Kiren S.; Gugiu, Mihaiela R.; Justice, Laura M.; Bowles, Ryan P.; Skibbe, Lori E.; Piasta, Shayne B.

2016-01-01

Purpose: Prior theoretical and empirical work has referenced several broad stages of narrative development, particularly in terms of young children's understanding of story structure. However, there is considerable variation in how story structure has been defined and assessed across these studies. The aims of the present study were threefold: (a)…

Child Find Activities under the Individuals with Disabilities Education Act: Recent Case Law

ERIC Educational Resources Information Center

Ennis, Robin Parks; Blanton, Kimberly; Katsiyannis, Antonis

2017-01-01

Since the enactment of the Education for All Handicapped Children Act (IDEA's forerunner) in 1975, an important requirement has been Child Find activities. According to Shapiro and Derrington (2004), Child Find is broadly defined as the entire range of activities, including public awareness, identification, referral, eligibility determination, and…

Global rainfall erosivity assessment based on high-temporal resolution rainfall records

USDA-ARS?s Scientific Manuscript database

Rainfall erosivity quantifies the climatic effect on water erosion. In the framework of the Universal Soil Loss Equation, rainfall erosivity, also known as the R-factor, is defined as the mean annual sum of event erosivity values. For a new global soil erosion assessment, also in the broad context...

Basic Course in Highway Traffic Records. Instructor's Guide.

ERIC Educational Resources Information Center

National Highway Traffic Safety Administration (DOT), Washington, DC.

The scope and content of this traffic records course are outlined in a chart (Course Structure) and tabulation (Overview of Course Content). General course objectives follow the overview. These define for the instructor the broad objectives, module by module, which the course is designed to reach. The last part of this section gives a detailed…

Leisure Counselling, Coping Skills and Therapeutic Applications

ERIC Educational Resources Information Center

Juniper, Dean

2005-01-01

Leisure counselling is defined as the systematic exploitation of a client's past, existing or prospective hobbies, activities and interests for broad psychotherapeutic purposes. It functions as a powerful agent in the invigoration of a range of existing but inadequate coping skills, and can also act in an innovatory style when such key skills are…

Let's Have Some Capatence Here

ERIC Educational Resources Information Center

Brown, Reva Berman; McCartney, Sean

2003-01-01

Defines two competitive ideas--competence and capability--and argues that neither deals adequately with the central issue of the present. Provides a model, to place these ideas in conceptual space--the vertical axis of which is bounded by the extremes of narrow and broad focus, and the horizontal axis by the past and the future. Suggests that…

Entrepreneurial Attitudes and Behaviors that Can Help Prepare Successful Change-Agents in Education

ERIC Educational Resources Information Center

Borasi, Raffaella; Finnigan, Kara

2010-01-01

This article explores how the preparation of educators committed to improving education can capitalize on entrepreneurship when broadly defined as "transforming ideas into enterprises that generate economic, intellectual and/or social value." The article reports on the case-studies of six educators who have been successful change-agents in a…

Conceptualizing On-the-Job Learning Styles

ERIC Educational Resources Information Center

Berings, Marjolein G. M. C.; Poell, Rob F.; Simons, P. Robert-Jan

2005-01-01

The broad aims of this study are to gain insight into employees' on-the-job learning activities to help them improve their on-the-job learning. The authors define on-the-job learning styles and operationalize the concept to include both mental and overt learning styles and both interpersonal and intrapersonal learning styles. Organizations and…

Secondary Mathematics Coaching: The Components of Effective Mathematics Coaching and Implications

ERIC Educational Resources Information Center

Bengo, Priscilla

2016-01-01

Mathematics coaching, which can be defined broadly as job-embedded learning for mathematics teachers with someone who can help, is being used in Canada to improve teaching practice and increase student achievement. Mathematics coaching research is quite new with little written on the components of effective coaching. The paper attempts to…

Adaptation resources for agriculture: responding to climate variability and change in the midwest and northeast

USDA-ARS?s Scientific Manuscript database

This report is intended to provide perspective, information, and tools to support agricultural producers in the Midwest and Northeast regions of the U.S. in responding to climate variability and change. Climate change adaptation can be broadly defined to include all adjustments, both planned and unp...

An Investigation of Mathematical Modeling with Pre-Service Secondary Mathematics Teachers

ERIC Educational Resources Information Center

Thrasher, Emily Plunkett

2016-01-01

The goal of this thesis was to investigate and enhance our understanding of what occurs while pre-service mathematics teachers engage in a mathematical modeling unit that is broadly based upon mathematical modeling as defined by the Common Core State Standards for Mathematics (National Governors Association Center for Best Practices & Council…

The Evolution of Student Services in the UK

ERIC Educational Resources Information Center

Morgan, Michelle

2012-01-01

There is limited literature that looks at the evolution of student services in the UK and their effectiveness in providing student support. Student support is broadly defined as all services that support students to learn. Academic and non-academic support are essential mechanisms in providing holistic student support. In this article, the author…

Defining old growth in the Southeast: example of cypress

Treesearch

Margaret S. Devall; Paul C. van Deusen; Gregory A. Reams

1999-01-01

There is a lot of misunderstanding over what comprises an old growth stand, because there is no well accepted definition of old growth. Malcolm Hunter proposed a broad conceptual definition: "old-growth forests are relatively old and relatively undisturbed by humans." Because there can be large differences among forest types, Hunter suggested that specific...

(En)Gendering Videogame Development: A Feminist Approach to Gender, Education, and Game Studies

ERIC Educational Resources Information Center

Dahya, Negin; Jenson, Jennifer; Fong, Katrina

2017-01-01

Few studies compare educational programming designed on principles of inclusive pedagogy and feminist practice for both girls and boys. Broadly defined, inclusive pedagogy refers to theory and practice in education that is adaptable and responsive to the intersections of difference (class, race, culture, gender, sexuality, ability) and aims to…

Building Indicators of Community College Outcomes.

ERIC Educational Resources Information Center

Cohen, Arthur M.

In 1989, the Center for the Study of Community Colleges began a project to define and promote student transfer from community colleges to four-year colleges and universities. The project had four purposes: establish a definition of transfer; gather and analyze transfer data from a broad sample of colleges; assist the colleges in establishing…

The Institution as a Citizen: How Colleges and Universities Enhance Their Civic Roles. Working Paper.

ERIC Educational Resources Information Center

Thomas, Nancy L.

This paper considers how colleges and universities can best fulfill the commitment of service to external communities, broadly defined to include local, national, and international concerns. Data come from interviews with key institutional representatives. The first section of the paper offers specific examples of how various colleges and…

Education Policy Studies in South Africa, 1995-2006

ERIC Educational Resources Information Center

Deacon, Roger; Osman, Ruksana; Buchler, Michelle

2010-01-01

This article reports on findings pertaining to scholarship in education policy drawn from a wider study on all education research in South Africa from 1995 to 2006. This study, which defined education research as broadly pertaining to teaching and/or learning, obtained extensive data from a wide range of sources, including universities, public…

Beyond the "English Learner" Frame: Transnational Funds of Knowledge in Social Studies

ERIC Educational Resources Information Center

Dabach, Dafney Blanca; Fones, Aliza

2016-01-01

Transnationalism is a phenomenon that has consequences for education, broadly defined. Even as youth engage in transnational practices that expand their knowledge across borders, immigrant students in U.S. schools are often framed narrowly as "English learners" and their forms of knowledge may be erased. Synthesizing literature at the…

A Survey of Scholarly Literature Describing the Field of Bioinformatics Education and Bioinformatics Educational Research

ERIC Educational Resources Information Center

Magana, Alejandra J.; Taleyarkhan, Manaz; Alvarado, Daniela Rivera; Kane, Michael; Springer, John; Clase, Kari

2014-01-01

Bioinformatics education can be broadly defined as the teaching and learning of the use of computer and information technology, along with mathematical and statistical analysis for gathering, storing, analyzing, interpreting, and integrating data to solve biological problems. The recent surge of genomics, proteomics, and structural biology in the…

CRYPTIC NEOGENE VICARIANCE AND QUATERNARY DISPERSAL OF THE RED-SPOTTED TOAD (BUFO PUNCTATUS) INSIGHTS ON THE EVOLUTION OF NORTH AMERICAN WARM DESERT BIOTAS

EPA Science Inventory

We define the geographic distributions of embedded evolutionary mitochondrial DNA (mtDNA) lineages (clades) within a broadly distributed, arid- dwelling toad, Bufo punctatus, and evaluate these patterns as they relate to hypothesized vicariant events leading to the formation of b...

"A Reason to Write": Exploring Writing Epistemologies in Two Contexts

ERIC Educational Resources Information Center

Pahl, Kate

2012-01-01

This article argues that it is important to take account of children's epistemologies of writing when exploring writing ecologies in homes and communities. Writing as more broadly defined by children and young people might include different forms of notation, inscription systems and decoration of objects in the home. Drawing on two research…

Leadership Experiences and Characteristics of Chairs of Academic Departments of Psychiatry

ERIC Educational Resources Information Center

Keith, Samuel J.; Buckley, Peter F.

2011-01-01

Objective: Effective leadership in academic medicine requires a broad constellation of skills, experiences, and core values. The authors sought to describe and define these. Method: The authors conducted a web-based survey among 132 Chairs of North American departments of psychiatry. Results: Eighty-five Chairs (64%) responded to the survey, the…

THE COMPREHENSIVE EDUCATIONAL PROGRAM FOR WEST VIRGINIA SCHOOLS.

ERIC Educational Resources Information Center

SMITH, REX M.

THE COMPREHENSIVE EDUCATIONAL PROGRAM IS DEFINED AS ONE WHICH MEETS THE NEEDS OF ALL STUDENTS AT ALL LEVELS BY PROVIDING COMPREHENSIVE AND ELECTIVE PROGRAMS FOR THOSE STUDENTS REQUIRING SALABLE SKILLS UPON GRADUATION FROM HIGH SCHOOL, AS WELL AS A BROAD ELECTIVE PROGRAM FOR THOSE WHO WISH TO CONTINUE THEIR EDUCATION. INCLUDED ARE SUMMARIES OF THE…

Government-Funded Students and Courses: January to September 2015. Australian Vocational Education and Training Statistics

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2015

2015-01-01

This publication provides a summary of data relating to students, programs, training providers and funding in Australia's government-funded vocational education and training (VET) system (broadly defined as all activity delivered by government providers and government-funded activity delivered by community education and private training…

Looking Backward: James Madison University's General Education Reform.

ERIC Educational Resources Information Center

Reynolds, Charles W.; Allain, Violet Anselmini; Erwin, T. Dary; Halpern, Linda Cabe; McNallie, Robin; Ross, Martha K.

1998-01-01

Describes the new general education program at James Madison University (Virginia) and the process by which it was developed. Indicates that the program is organized by five broad areas of knowledge that are defined by interdisciplinary clusters of learning objectives, which in turn were developed using input from every academic department on…

Reference Manual for Machine-Readable Descriptions of Research Projects and Institutions.

ERIC Educational Resources Information Center

Dierickx, Harold; Hopkinson, Alan

This reference manual presents a standardized communication format for the exchange between databases or other information services of machine-readable information on research in progress. The manual is produced in loose-leaf format to facilitate updating. Its first section defines in broad outline the format and content of applicable records. A…

Lectotype designation for Murex nebula Montagu 1803 (Mangeliidae) and its implications for Bela Leach in Gray 1847.

PubMed

Daniele, Scarponi; Landau, Bernard; Janssen, Ronald; Morgenroth, Holly; Bella, Giano Della

2014-11-12

Bela Leach in Gray is a misapplied and broadly defined genus within the family Mangeliidae Fischer, 1883. Examination of material from the Montagu collection at the Royal Albert Memorial Museum & Art Gallery (RAMM) in Exeter (UK) led to the discovery of six specimens of Murex nebula Montagu 1803 (the type species of Bela). This material is considered to belong to the original lot used by Montagu to define his species. We selected the best-preserved specimen as a lectotype. The lectotype and paralectotypes deposited at the RAMM are fully described and illustrated. Furthermore, diagnostic characters for recognizing B. nebula specimens are presented: protoconch shows weak ornamentation; teleoconch is fusiform with slightly convex whorls characterized by broad, suture-to-suture ribs and dense but weak spiral elements; outer lip is thin; anal sinus is shallow, placed on the shoulder ramp. These key features are of basic importance for: i) restricting the usage of the genus Bela and promoting its stability and consistent usage in literature and ii) separating two allied (and sometimes interchanged) genera: Bela and Mangelia Risso 1826.

2D nanomaterials assembled from sequence-defined molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mu, Peng; Zhou, Guangwen; Chen, Chun-Long

Two dimensional (2D) nanomaterials have attracted broad interest owing to their unique physical and chemical properties with potential applications in electronics, chemistry, biology, medicine and pharmaceutics. Due to the current limitations of traditional 2D nanomaterials (e.g., graphene and graphene oxide) in tuning surface chemistry and compositions, 2D nanomaterials assembled from sequence-defined molecules (e.g., DNAs, proteins, peptides and peptoids) have recently been developed. They represent an emerging class of 2D nanomaterials with attractive physical and chemical properties. In this mini-review, we summarize the recent progress in the synthesis and applications of this type of sequence-defined 2D nanomaterials. The challenges and opportunitiesmore » in this new field are also discussed.« less

Neural precursors of future liking and affective reciprocity

PubMed Central

Zerubavel, Noam; Hoffman, Mark Anthony; Reich, Adam; Ochsner, Kevin N.; Bearman, Peter

2018-01-01

Why do certain group members end up liking each other more than others? How does affective reciprocity arise in human groups? The prediction of interpersonal sentiment has been a long-standing pursuit in the social sciences. We combined fMRI and longitudinal social network data to test whether newly acquainted group members’ reward-related neural responses to images of one another’s faces predict their future interpersonal sentiment, even many months later. Specifically, we analyze associations between relationship-specific valuation activity and relationship-specific future liking. We found that one’s own future (T2) liking of a particular group member is predicted jointly by actor’s initial (T1) neural valuation of partner and by that partner’s initial (T1) neural valuation of actor. These actor and partner effects exhibited equivalent predictive strength and were robust when statistically controlling for each other, both individuals’ initial liking, and other potential drivers of liking. Behavioral findings indicated that liking was initially unreciprocated at T1 yet became strongly reciprocated by T2. The emergence of affective reciprocity was partly explained by the reciprocal pathways linking dyad members’ T1 neural data both to their own and to each other’s T2 liking outcomes. These findings elucidate interpersonal brain mechanisms that define how we ultimately end up liking particular interaction partners, how group members’ initially idiosyncratic sentiments become reciprocated, and more broadly, how dyads evolve. This study advances a flexible framework for researching the neural foundations of interpersonal sentiments and social relations that—conceptually, methodologically, and statistically—emphasizes group members’ neural interdependence. PMID:29632195

Neural precursors of future liking and affective reciprocity.

PubMed

Zerubavel, Noam; Hoffman, Mark Anthony; Reich, Adam; Ochsner, Kevin N; Bearman, Peter

2018-04-24

Why do certain group members end up liking each other more than others? How does affective reciprocity arise in human groups? The prediction of interpersonal sentiment has been a long-standing pursuit in the social sciences. We combined fMRI and longitudinal social network data to test whether newly acquainted group members' reward-related neural responses to images of one another's faces predict their future interpersonal sentiment, even many months later. Specifically, we analyze associations between relationship-specific valuation activity and relationship-specific future liking. We found that one's own future (T2) liking of a particular group member is predicted jointly by actor's initial (T1) neural valuation of partner and by that partner's initial (T1) neural valuation of actor. These actor and partner effects exhibited equivalent predictive strength and were robust when statistically controlling for each other, both individuals' initial liking, and other potential drivers of liking. Behavioral findings indicated that liking was initially unreciprocated at T1 yet became strongly reciprocated by T2. The emergence of affective reciprocity was partly explained by the reciprocal pathways linking dyad members' T1 neural data both to their own and to each other's T2 liking outcomes. These findings elucidate interpersonal brain mechanisms that define how we ultimately end up liking particular interaction partners, how group members' initially idiosyncratic sentiments become reciprocated, and more broadly, how dyads evolve. This study advances a flexible framework for researching the neural foundations of interpersonal sentiments and social relations that-conceptually, methodologically, and statistically-emphasizes group members' neural interdependence. Copyright © 2018 the Author(s). Published by PNAS.

Understanding the impact of interprofessional collaboration on the quality of care: a case report from a small-scale resource limited health care environment.

PubMed

Busari, Jamiu O; Moll, Franka M; Duits, Ashley J

2017-01-01

A critical assessment of current health care practices, as well as the training needs of various health care providers, is crucial for improving patient care. Several approaches have been proposed for defining these needs with attention on communication as a key competency for effective collaboration. Taking our cultural context, resource limitations, and small-scale setting into account, we researched the applicability of a mixed focus group approach for analysis of the communication between doctors and nurses, as well as the measures for improvement. Assessment of nurse-physician communication perception in patient care in a Caribbean setting. Focus group sessions consisting of nurses, interns, and medical specialists were conducted using an ethnographic approach, paying attention to existing communication, risk evaluation, and recommendations for improvement. Data derived from the focus group sessions were analyzed by thematic synthesis method with descriptive themes and development of analytic themes. The initial focus group sessions produced an extensive list of key recommendations which could be clustered into three domains (standardization, sustainment, and collaboration). Further discussion of these domains in focus groups showed nurses' and physicians' domain perspectives and effects on patient care to be broadly similar. Risks related to lack of information, knowledge sharing, and professional respect were clearly described by the participants. The described mixed focus group session approach for effectively determining current interprofessional communication and key improvement areas seems suitable for our small-scale, limited resource setting. The impact of the cultural context should be further evaluated by a similar study in a different cultural context.

High genetic diversities between isolates of the fish parasite Cryptocaryon irritans (Ciliophora) suggest multiple cryptic species.

PubMed

Chi, Hongshu; Taik, Patricia; Foley, Emily J; Racicot, Alycia C; Gray, Hilary M; Guzzetta, Katherine E; Lin, Hsin-Yun; Song, Yen-Ling; Tung, Che-Huang; Zenke, Kosuke; Yoshinaga, Tomoyoshi; Cheng, Chao-Yin; Chang, Wei-Jen; Gong, Hui

2017-07-01

The ciliate protozoan Cryptocaryon irritans parasitizes marine fish and causes lethal white spot disease. Sporadic infections as well as large-scale outbreaks have been reported globally and the parasite's broad host range poses particular threat to the aquaculture and ornamental fish markets. In order to better understand C. irritans' population structure, we sequenced and compared mitochondrial cox-1, SSU rRNA, and ITS-1 sequences from 8 new isolates of C. irritans collected in China, Japan, and Taiwan. We detected two SSU rRNA haplotypes, which differ at three positions, separating the isolates into two main groups (I and II). Cox-1 sequences also support the division into two groups, and the cox-1 divergence between these two groups is unexpectedly high (9.28% for 1582 nucleotide positions). The divergence is much greater than that detected in Ichthyophthirius multifiliis, the ciliate protozoan causing freshwater white spot disease in fish, where intraspecies divergence on cox-1 sequence is only 1.95%. ITS-1 sequences derived from these eight isolates and from all other C. irritans isolates (deposited in the GenBank) not only support the two groups, but further suggest the presence of a third group with even greater sequence divergence. Finally, a small Ka/Ks ratio estimated from cox-1 sequences suggests that this gene in C. irritans remains under strong purifying selection. Taken together, the C. irritans species may consists of many subspecies and/or syngens. Further work is needed to determine if there is reproductive isolation between the groups we have defined. Copyright © 2017 Elsevier Inc. All rights reserved.

A qualitative analysis among regular waterpipe tobacco smokers in London universities.

PubMed

Jawad, M; Jawad, S; Mehdi, A; Sardar, A; Jawad, A M; Hamilton, F L

2013-10-01

Waterpipe smoking is popular in the West despite the significant harm associated with its use. Little is known about the habits and practices of British smokers. A total of 32 regular waterpipe smokers attended focus groups, where trained facilitators explored knowledge, belief and attitudes to waterpipes. Transcripts were thematically analysed and grouped into seven broad categories. Waterpipes played a clearly defined social role, accentuated by reduced harm perception and greater social acceptance than cigarettes. Knowledge about waterpipes was lacking, partly due to the lack of media attention. Addiction was described as a 'social addiction', although this may mask true nicotine addiction. Waterpipe smokers were less interested in quitting due to intermittent smoking patterns, reinforcing the belief of reduced exposure to harm. Legislative issues were explored, including the need to legislate on waterpipes on a par with cigarettes. Waterpipe smokers exhibited specific habits and attitudes not traditionally seen in cigarette smokers. It is important to encourage education to dispel the myths surrounding reduced harm perception and addiction to tackle its strong social acceptance. Legislation should play a more active role in prevention and education, and more emphasis should be placed on gathering nationwide epidemiological data to gauge the potential for escalation.

Degree of adaptive response in urban tolerant birds shows influence of habitat-of-origin

PubMed Central

2014-01-01

Urban exploiters and adapters are often coalesced under a term of convenience as ‘urban tolerant’. This useful but simplistic characterisation masks a more nuanced interplay between and within assemblages of birds that are more or less well adapted to a range of urban habitats. I test the hypotheses that objectively-defined urban exploiter and suburban adapter assemblages within the broad urban tolerant grouping in Melbourne vary in their responses within the larger group to predictor variables, and that the most explanatory predictor variables vary between the two assemblages. A paired, partitioned analysis of exploiter and adapter preferences for points along the urban–rural gradient was undertaken to decompose the overall trend into diagnosable parts for each assemblage. In a similar way to that in which time since establishment has been found to be related to high urban densities of some bird species and biogeographic origin predictive of urban adaptation extent, habitat origins of members of bird assemblages influence the degree to which they become urban tolerant. Bird species that objectively classify as urban tolerant will further classify as either exploiters or adapters according to the degree of openness of their habitats-of-origin. PMID:24688881

Eliciting societal preferences of reimbursement decision criteria for anti cancer drugs in South Korea.

PubMed

Kwon, Sun-Hong; Park, Sun-Kyeong; Byun, Ji-Hye; Lee, Eui-Kyung

2017-08-01

In order to look beyond the cost-effectiveness analysis, this study used a multi-criteria decision analysis (MCDA), which reflects societal values with regard to reimbursement decisions. This study aims to elicit societal preferences of the reimbursement decision criteria for anti cancer drugs from public and healthcare professionals. Eight criteria were defined based on a literature review and focus group sessions: disease severity, disease population size, pediatrics targets, unmet needs, innovation, clinical benefits, cost-effectiveness, and budget impacts. Using quota sampling and purposive sampling, 300 participants from the Korean public and 30 healthcare professionals were selected for the survey. Preferences were elicited using an analytic hierarchy process. Both groups rated clinical benefits the highest, followed by cost-effectiveness and disease severity, but differed with regard to disease population size and unmet needs. Innovation was the least preferred criteria. Clinical benefits and other social values should be reflected appropriately with cost-effectiveness in healthcare coverage. MCDA can be used to assess decision priorities for complicated health policy decisions, including reimbursement decisions. It is a promising method for making logical and transparent drug reimbursement decisions that consider a broad range of factors, which are perceived as important by relevant stakeholders.

Structure and biodiversity of coralligenous assemblages dominated by the precious red coral Corallium rubrum over broad spatial scales

PubMed Central

Casas-Güell, Edgar; Cebrian, Emma; Garrabou, Joaquim; Ledoux, Jean-Baptiste; Linares, Cristina; Teixidó, Núria

2016-01-01

Data on species diversity and structure in coralligenous outcrops dominated by Corallium rubrum are lacking. A hierarchical sampling including 3 localities and 9 sites covering more than 400 km of rocky coasts in NW Mediterranean, was designed to characterize the spatial variability of structure, composition and diversity of perennial species inhabiting coralligenous outcrops. We estimated species/taxa composition and abundance. Eight morpho-functional groups were defined according to their life span and growth to characterize the structural complexity of the outcrops. The species composition and structural complexity differed consistently across all spatial scales considered. The lowest and the highest variability were found among localities (separated by >200 km) and within sites (separated by 1–5 km), respectively supporting differences in diversity indices. The morpho-functional groups displayed a consistent spatial arrangement in terms of the number, size and shape of patches across study sites. These results contribute to filling the gap on the understanding of assemblage composition and structure and to build baselines to assess the response of this of this highly threatened habitat to anthropogenic disturbances. PMID:27857209

Using Machine Learning to Discover Latent Social Phenotypes in Free-Ranging Macaques

PubMed Central

Madlon-Kay, Seth; Brent, Lauren J. N.; Heller, Katherine A.; Platt, Michael L.

2017-01-01

Investigating the biological bases of social phenotypes is challenging because social behavior is both high-dimensional and richly structured, and biological factors are more likely to influence complex patterns of behavior rather than any single behavior in isolation. The space of all possible patterns of interactions among behaviors is too large to investigate using conventional statistical methods. In order to quantitatively define social phenotypes from natural behavior, we developed a machine learning model to identify and measure patterns of behavior in naturalistic observational data, as well as their relationships to biological, environmental, and demographic sources of variation. We applied this model to extensive observations of natural behavior in free-ranging rhesus macaques, and identified behavioral states that appeared to capture periods of social isolation, competition over food, conflicts among groups, and affiliative coexistence. Phenotypes, represented as the rate of being in each state for a particular animal, were strongly and broadly influenced by dominance rank, sex, and social group membership. We also identified two states for which variation in rates had a substantial genetic component. We discuss how this model can be extended to identify the contributions to social phenotypes of particular genetic pathways. PMID:28754001

A Review of Current and Prospective Factors for Classification of Civil Unmanned Aircraft Systems

NASA Technical Reports Server (NTRS)

Hayhurst, Kelly J.; Maddalon, Jeffrey M.; Morris, A. Terry; Neogi, Natasha; Verstynen, Harry A.

2014-01-01

While progress is being made on integrating unmanned aircraft systems (UAS) into our national airspace on a broad scale, much work remains to establish appropriate certification standards and operational procedures, particularly with respect to routine commercial operations. This paper summarizes research to examine the extent to which today's civil aircraft taxonomy applies to UAS, and, if needed, how that taxonomy could be amended to better cover different UAS designs and operations. Factors that shape the current taxonomy, as defined in the Federal Aviation Regulations, were assessed for applicability to UAS, potential incompatibilities were identified, and additional factors were proposed that might be useful for an updated aircraft taxonomy intended to cover UAS. The results suggest the possibility of constructing new groups in the taxonomy for UAS under a restricted category that share common airworthiness standards. Establishing distinct groups for UAS and associated standards that enable low risk operations for compensation or hire could be a timely step toward full integration. Such a step would allow the civil aviation industry and regulators to gain valuable experience with UAS while carefully controlling access and potential harm to the aviation system as a whole.

Developments in the Classification and Treatment of the Juvenile Idiopathic Inflammatory Myopathies

PubMed Central

Rider, Lisa G.; Katz, James D.; Jones, Olcay Y.

2013-01-01

The juvenile idiopathic inflammatory myopathies (JIIM) are rare, heterogeneous autoimmune diseases that share chronic muscle inflammation and weakness. JIIM broadly includes three major clinicopathologic groups: juvenile dermatomyositis, juvenile polymyositis, and overlap myositis. A growing spectrum of clinicopathologic groups and serologic phenotypes defined by the presence of myositis-specific or myositis-associated autoantibodies are now recognized, each with differing demographics, clinical manifestations, laboratory findings, and prognoses. With the first multi-center collaborative studies and controlled trials using standardized preliminarily validated outcome measures, the therapy of juvenile myositis has advanced. Although daily oral corticosteroids remain the backbone of treatment, disease-modifying anti-rheumatic drugs (DMARDs) are almost always used as adjunctive therapy. Methotrexate is the conventional DMARD for the initial therapy, either alone or combined with intravenous pulse methylprednisolone, and/or intravenous immunoglobulin for patients with moderate to severe disease. Cyclosporine may be added to these or serve as an alternative to methotrexate. Other drugs and biologic therapies, including mycophenolate mofetil, tacrolimus, cyclophosphamide, rituximab, and infliximab, might benefit selected patients with recalcitrant disease, unacceptable steroid toxicity, or patients with risk factors for poor prognosis. The treatment of cutaneous disease, calcinosis, and the role for rehabilitation are also discussed. PMID:24182859

[Pharmacological, toxicological, deontologic, and medico-legal aspects of the use of appetite suppressant agents in "weight-loss cures"].

PubMed

Carolei, L; Ermio, G; Accorinti, N; Meo, G; Lamberti, V; De Sarro, G

1997-01-01

The pharmacological, deontologic and medico-legal aspects in the use of appetite suppressant drugs have been evaluated. Appetite suppressant drugs used in the treatment of obesity are divided into 2 broad pharmacological categories: those acting via brain catecholamine pathways and those acting via serotonin pathways. Of the former group, amphetamines and phenimetrazines are no longer used because of their stimulant properties and addictive potential. The remaining drugs of this group have some sympathomimetic and stimulant properties. Anorectic drugs which promote serotonin neurotransmission have no such stimulant or sympathomimetic properties. They reduce appetite and food intake and are effective in the treatment of obesity. If they are not used appropriately, appetite suppressants can be of no therapeutic benefit and cause marked health risks. As regards to anorectic drugs, the 13/4/1995 act "Rules and limits in preparing drugs containing anorectic substances", precisely defines rules about selling and use of those substances. Behavior of health care personnel neglecting observance of the rule, could be interpreted as "imprudence", "negligence" and "inexpertness" in designing and managing a fat-reducing diet, that may imply, in case of damage to the patient, a professional fault.

What is 'binge drinking'? Perceptions of Australian adolescents and adults, and implications for mass media campaigns.

PubMed

Jones, Sandra C; Gordon, Chloe S; Andrews, Kelly

2016-10-01

While the term 'binge drinking' has no definitive definition, it is commonly used in lay conversation and mass media communication campaigns. It is important to understand how the general population interprets the term, and their positive and negative perceptions of this behaviour. A convenience sample of 549 participants from two Australian towns completed a survey on perceptions of binge drinking; 221 adolescents, 104 parents of adolescents and 224 adult community members. Across all three groups, binge drinking was defined using broad descriptors; few respondents referred to specific consumption levels and those who did varied widely in the quantities specified. The majority of respondents described binge drinking negatively and, in most cases, more negatively for adolescents than adults. However, both adult groups perceived binge drinking to be more enjoyable and pleasant for adolescents than for adults, and more enjoyable and pleasant than adolescents did themselves. There is a need for shared understanding of terms to ensure that educational interventions and communication campaigns are using the same definitions as their target audiences. There is also a need to ensure adults are not providing young people with mixed messages about excessive alcohol consumption. © 2016 Public Health Association of Australia.

Community composition and cellulase activity of cellulolytic bacteria from forest soils planted with broad-leaved deciduous and evergreen trees.

PubMed

Yang, Jiang-Ke; Zhang, Jing-Jing; Yu, Heng-Yu; Cheng, Jian-Wen; Miao, Li-Hong

2014-02-01

Cellulolytic bacteria in forest soil provide carbon sources to improve the soil fertility and sustain the nutrient balance of the forest ecological system through the decomposition of cellulosic remains. These bacteria can also be utilized for the biological conversion of biomass into renewable biofuels. In this study, the community compositions and activities of cellulolytic bacteria in the soils of forests planted with broad-leaved deciduous (Chang Qing Garden, CQG) and broad-leaved evergreen (Forest Park, FP) trees in Wuhan, China were resolved through restriction fragment length polymorphism (RFLP) and sequencing analysis of the 16S rRNA gene. All of the isolates exhibited 35 RFLP fingerprint patterns and were clustered into six groups at a similarity level of 50 %. The phylogeny analysis based on the 16S rRNA gene sequence revealed that these RFLP groups could be clustered into three phylogenetic groups and further divided into six subgroups at a higher resolution. Group I consists of isolates from Bacillus cereus, Bacillus subtilis complex (I-A) and from Paenibacillus amylolyticus-related complex (I-B) and exhibited the highest cellulase activity among all of the cellulolytic bacteria isolates. Cluster II consists of isolates belonging to Microbacterium testaceum (II-A), Chryseobacterium indoltheticum (II-B), and Flavobacterium pectinovorum and the related complex (II-C). Cluster III consists of isolates belonging to Pseudomonas putida-related species. The community shift with respect to the plant species and the soil properties was evidenced by the phylogenetic composition of the communities. Groups I-A and I-B, which account for 36.0 % of the cellulolytic communities in the CQG site, are the dominant groups (88.4 %) in the FP site. Alternatively, the ratio of the bacteria belonging to group III (P. putida-related isolates) shifted from 28.0 % in CQG to 4.0 % in FP. The soil nutrient analysis revealed that the CQG site planted with deciduous broad-leaved trees has a richer organic nutrient (total organic carbon and total nitrogen) than the FP site planted with evergreen broad-leaved trees. Against this background, the population density and the diversity of cellulolytic bacteria in the CQG site are clearly higher than those in the FP site, and the latter was dominated with high-cellulase-activity Bacillus- and Paenibacillus-related bacteria. The canonical correspondence analysis further indicated that the distribution of these groups is correlated with the FP site, whereas groups II and III are correlated with the organic nutrient-rich CQG site.

75 FR 54872 - Drinking Water Strategy Contaminants as Group(s)-Notice of Public Stakeholder Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... technologies to address health risks posed by a broad array of contaminants; using the authority of multiple... potential contaminant groups, share advantages and disadvantages of various groups, identify issues needing...

Organisational design for an integrated oncological department

PubMed Central

Meiss-de Haas, Ch.L.; Falkmann, H.; Douma, J.; van Gassel, J.G.; Peters, W.G.; van Mierlo, R.; van Turnhout, J.M.; Verhagen, C.A.H.H.V.M.; Schrijvers, A.J.P.

2001-01-01

Abstract Objective The outcomes of a Strength, Weakness, Opportunities and Threat (SWOT) analysis of three Integrated Oncological Departments were compared with their present situation three years later to define factors that can influence a successful implementation and development of an Integrated Oncological Department in- and outside (i.e. home care) the hospital. Research design Comparative Qualitative Case Study. Methods Auditing based on care-as-usual norms by an external, experienced auditing committee. Research setting Integrated Oncological Departments of three hospitals. Results Successful multidisciplinary care in an integrated, oncological department needs broad support inside the hospital and a well-defined organisational plan. PMID:16896411

Do-it-yourself networks: a novel method of generating weighted networks.

PubMed

Shanafelt, D W; Salau, K R; Baggio, J A

2017-11-01

Network theory is finding applications in the life and social sciences for ecology, epidemiology, finance and social-ecological systems. While there are methods to generate specific types of networks, the broad literature is focused on generating unweighted networks. In this paper, we present a framework for generating weighted networks that satisfy user-defined criteria. Each criterion hierarchically defines a feature of the network and, in doing so, complements existing algorithms in the literature. We use a general example of ecological species dispersal to illustrate the method and provide open-source code for academic purposes.

AAVP Recommendations for Core Competency Standards Relating to Parasitological Knowledge and Skills.

PubMed

Snowden, Karen F; Krecek, Rosina C; Bowman, Dwight D

As part of the accreditation process, the American Veterinary Medical Association Council on Education has defined nine broad areas of core competencies that must be met by graduating students earning a Doctor of Veterinary Medicine degree. To define competencies in veterinary parasitology, the American Association of Veterinary Parasitologists (AAVP) has developed a detailed list of knowledge and skills that are recommended for inclusion in professional curricula. These recommendations were developed by instructors from colleges/schools of veterinary medicine in the US, Canada, and the Caribbean, and were reviewed and endorsed following AAVP guidelines.

Forging a signature of in vivo senescence.

PubMed

Sharpless, Norman E; Sherr, Charles J

2015-07-01

'Cellular senescence', a term originally defining the characteristics of cultured cells that exceed their replicative limit, has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. Proposed relationships between cellular senescence, tumour suppression, loss of tissue regenerative capacity and ageing suffer from lack of uniform definition and consistently applied criteria. Here, we highlight caveats in interpreting the importance of suboptimal senescence-associated biomarkers, expressed either alone or in combination. We advocate that more-specific descriptors be substituted for the now broadly applied umbrella term 'senescence' in defining the suite of diverse physiological responses to cellular stress.

Are Some Attitudes More Self-Defining Than Others? Assessing Self-Related Attitude Functions and Their Consequences.

PubMed

Zunick, Peter V; Teeny, Jacob D; Fazio, Russell H

2017-08-01

Attitudes serve multiple functions, some related to the self-concept. We call attitudes that help people define who they are "self-defining." Across four studies, we tested a brief self-report measure of the extent to which an attitude is self-defining. Studies 1 and 2 showed that self-defining attitudes tend to be extreme, positive, and unambivalent. Studies 3 and 4 produced two main findings. First, self-definition was related to, but not redundant with, a number of other characteristics of the attitude (e.g., attitude certainty). Second, self-definition predicted participants' intentions to spontaneously advocate and, in Study 4, their reactions to an opportunity to advocate behaviorally (i.e., writing about their attitude in an optional response box) following a self-threat. Overall, the results highlight the utility of this approach and, more broadly, demonstrate the value of considering the role of the self in attitudinal processes, and vice versa.

Approach to cerebrospinal fluid (CSF) biomarker discovery and evaluation in HIV infection.

PubMed

Price, Richard W; Peterson, Julia; Fuchs, Dietmar; Angel, Thomas E; Zetterberg, Henrik; Hagberg, Lars; Spudich, Serena; Smith, Richard D; Jacobs, Jon M; Brown, Joseph N; Gisslen, Magnus

2013-12-01

Central nervous system (CNS) infection is a nearly universal facet of systemic HIV infection that varies in character and neurological consequences. While clinical staging and neuropsychological test performance have been helpful in evaluating patients, cerebrospinal fluid (CSF) biomarkers present a valuable and objective approach to more accurate diagnosis, assessment of treatment effects and understanding of evolving pathobiology. We review some lessons from our recent experience with CSF biomarker studies. We have used two approaches to biomarker analysis: targeted, hypothesis-driven and non-targeted exploratory discovery methods. We illustrate the first with data from a cross-sectional study of defined subject groups across the spectrum of systemic and CNS disease progression and the second with a longitudinal study of the CSF proteome in subjects initiating antiretroviral treatment. Both approaches can be useful and, indeed, complementary. The first is helpful in assessing known or hypothesized biomarkers while the second can identify novel biomarkers and point to broad interactions in pathogenesis. Common to both is the need for well-defined samples and subjects that span a spectrum of biological activity and biomarker concentrations. Previously-defined guide biomarkers of CNS infection, inflammation and neural injury are useful in categorizing samples for analysis and providing critical biological context for biomarker discovery studies. CSF biomarkers represent an underutilized but valuable approach to understanding the interactions of HIV and the CNS and to more objective diagnosis and assessment of disease activity. Both hypothesis-based and discovery methods can be useful in advancing the definition and use of these biomarkers.

Differential Item Functioning Detection across Two Methods of Defining Group Comparisons: Pairwise and Composite Group Comparisons

ERIC Educational Resources Information Center

Sari, Halil Ibrahim; Huggins, Anne Corinne

2015-01-01

This study compares two methods of defining groups for the detection of differential item functioning (DIF): (a) pairwise comparisons and (b) composite group comparisons. We aim to emphasize and empirically support the notion that the choice of pairwise versus composite group definitions in DIF is a reflection of how one defines fairness in DIF…

75 years of dryland science: Trends and gaps in arid ecology literature.

PubMed

Greenville, Aaron C; Dickman, Chris R; Wardle, Glenda M

2017-01-01

Growth in the publication of scientific articles is occurring at an exponential rate, prompting a growing need to synthesise information in a timely manner to combat urgent environmental problems and guide future research. Here, we undertake a topic analysis of dryland literature over the last 75 years (8218 articles) to identify areas in arid ecology that are well studied and topics that are emerging. Four topics-wetlands, mammal ecology, litter decomposition and spatial modelling, were identified as 'hot topics' that showed higher than average growth in publications from 1940 to 2015. Five topics-remote sensing, climate, habitat and spatial, agriculture and soils-microbes, were identified as 'cold topics', with lower than average growth over the survey period, but higher than average numbers of publications. Topics in arid ecology clustered into seven broad groups on word-based similarity. These groups ranged from mammal ecology and population genetics, broad-scale management and ecosystem modelling, plant ecology, agriculture and ecophysiology, to populations and paleoclimate. These patterns may reflect trends in the field of ecology more broadly. We also identified two broad research gaps in arid ecology: population genetics, and habitat and spatial research. Collaborations between population genetics and ecologists and investigations of ecological processes across spatial scales would contribute profitably to the advancement of arid ecology and to ecology more broadly.

Using Concept Mapping in the Development of a School of Public Health.

PubMed

Hsu, Laura J; Pacheco, Misty Y; Crabtree, Christopher; Maddock, Jay E

2015-07-01

Schools of Public Health have a wide variety of essential stakeholders. Broad input in program planning should assist in ensuring well-developed plans and strong community buy-in. The planning of a school can better address the needs of multiple stakeholders from systematic broad-based input from these constituents using concept mapping. In this study, we used concept mapping to prioritize a set of recommendations from diverse stakeholders to assist in the process of planning a school. A set of statements was generated on essential elements for the proposed school from a broad group of stakeholders. The statements were then distilled into unique themes, which were then rated on importance and feasibility. Cluster maps and pattern matches were used to analyze the ratings. Unique themes (N = 147) were identified and grouped into 12 clusters. Cluster themes included leadership, faculty, culture, school, and curriculum. Pattern matches revealed a significant, modest correlation between importance and feasibility (r = 0.27). A broad range of perspectives was used to identify relevant areas to address in the development of a school.

Morphological variation in glochidia shells of six species of Elliptio from Gulf of Mexico and Atlantic Coast drainages in the southeastern United States

USGS Publications Warehouse

O'Brien, C. A.; Williams, J.D.; Hoggarth, M.A.

2003-01-01

The genus Elliptio, with 36 currently recognized species, is the largest genus in the family Unionidae in North America. The genus is represented by two species, Elliptio crassidens and E. dilatata, in the Interior Basin and 34 species in drainages of the eastern Gulf of Mexico and Atlantic Coast. The paucity and variation of conchological characters in the genus Elliptio makes it extremely difficult to define species and determine relationships. We examined glochidia from six species of Elliptio in an effort to determine if there are useful characteristics for species level identification and/or characters for identification of species groups. Elliptio species were selected to represent different morphological groups from four drainages in the southeastern United States. The glochidia from E. crassidens, E. dariensis, E. hopetonensis, E. icterina, E. shepardiana, and E. mcmichaeli were qualitatively compared, using scanning electron microscopy, with each other and with descriptions of these and other Elliptio glochidia described in the literature. Two groups were identified. The crassidens group, including E. crassidens, E. dariensis, and E. mcmichaeli, had subtriangular glochidia with a triangular styliform hook extending from the ventral margin of the valve and rough exterior valve sculpturing. Adults of this group had wrinkled or corrugated sculpturing on the posterior slope of the shell. The complanata group, including E. hopetonensis, E. icterina, and E. shepardiana, had subelliptical glochidia with a broad flange extending the entire ventral margin and loose-looped exterior valve sculpturing. Adults of this group lack sculpturing on the posterior slope of the shell. Differences in glochidial morphometrics were found, however, additional work is needed to determine if they are reliable for species level identification.

Broad-spectrum Antibiotic Plus Metronidazole May Not Prevent the Deterioration of Necrotizing Enterocolitis From Stage II to III in Full-term and Near-term Infants

PubMed Central

Luo, Li-Juan; Li, Xin; Yang, Kai-Di; Lu, Jiang-Yi; Li, Lu-Quan

2015-01-01

Abstract Necrotizing enterocolitis (NEC) is the most common and frequently dangerous neonatal gastrointestinal disease. Studies have shown broad-spectrum antibiotics plus anaerobic antimicrobial therapy did not prevent the deterioration of NEC among very low birth preterm infants. However, few studies about this therapy which focused on full-term and near-term infant with NEC has been reported. The aim of this study was to evaluate the effect of broad-spectrum antibiotic plus metronidazole in preventing the deterioration of NEC from stage II to III in full-term and near-term infants. A retrospective cohort study based on the propensity score (PS) 1:1 matching was performed among the full-term and near-term infants with NEC (Bell stage ≥II). All infants who received broad-spectrum antibiotics were divided into 2 groups: group with metronidazole treatment (metronidazole was used ≥4 days continuously, 15 mg/kg/day) and group without metronidazole treatment. The depraved rates of stage II NEC between the 2 groups were compared. Meanwhile, the risk factors associated with the deterioration of stage II NEC were analyzed by case-control study in the PS-matched cases. A total of 229 infants met the inclusion criteria. Before PS-matching, we found the deterioration of NEC rate in the group with metronidazole treatment was higher than that in the group without metronidazole treatment (18.1% [28/155] vs 8.1% [6/74]; P = 0.048). After PS-matching, 73 pairs were matched, and the depraved rate of NEC in the group with metronidazole treatment was not lower than that in the group without metronidazole treatment (15.1% vs 8.2%; P = 0.2). Binary logistic regression analysis showed that sepsis after NEC (odds ratio [OR] 3.748, 95% confidence interval [CI] 1.171–11.998, P = 0.03), the need to use transfusion of blood products after diagnosis of NEC (OR 8.003, 95% CI 2.365–27.087, P = 0.00), and the need of longer time for nasogastric suction were risk factors for stage II NEC progressing to stage III (OR 1.102, 95% CI 1.004–1.21, P = 0.04). Broad-spectrum antibiotic plus metronidazole may not prevent the deterioration of NEC in full-term and near-term infants. Those infants who had sepsis required transfusion of blood products, and needed longer time for nasogastric suction after stage II NEC was more likely to progress to stage III. PMID:26496340

Bait attending fishes of the abyssal zone and hadal boundary: Community structure, functional groups and species distribution in the Kermadec, New Hebrides and Mariana trenches

NASA Astrophysics Data System (ADS)

Linley, T. D.; Stewart, A. L.; McMillan, P. J.; Clark, M. R.; Gerringer, M. E.; Drazen, J. C.; Fujii, T.; Jamieson, A. J.

2017-03-01

Baited landers were deployed at 83 stations at four locations in the west Pacific Ocean from bathyal to hadal depths: The Kermadec Trench, the New Hebrides Trench, the adjoining South Fiji Basin and the Mariana Trench. Forty-seven putative fish species were observed. Distinct fish faunal groups were identified based on maximum numbers and percentage of observations. Both analyses broadly agreed on the community structure: A bathyal group at <3000 m in the New Hebrides and Kermadec trenches, an abyssal group (3039 - 4692 m) in the Kermadec Trench, an abyssal-hadal transition zone (AHTZ) group (Kermadec: 4707-6068 m, Mariana: 4506-6198 m, New Hebrides: 2578-6898 m, South Fiji Basin: 4074-4101 m), and a hadal group of endemic snailfish in the Kermadec and Mariana trenches (6750-7669 m and 6831-8143 m respectively). The abyssal and hadal groups were absent from the New Hebrides Trench. Depth was the single factor that best explained the biological variation between samples (16%), the addition of temperature and average surface primary production for the previous year increased this to 36% of variation. The absence of the abyssal group from the New Hebrides Trench and South Fiji Basin was due to the absence of macrourids (Coryphaenoides spp.), which defined the group. The macrourids may be energetically limited in these areas. In their absence the species of the AHTZ group appear released of competition with the macrourids and are found far shallower at these sites. The fish groups had distinct feeding strategies while attending the bait: The bathyal and abyssal groups were almost exclusively necrophagous, the AHTZ group comprised predatory and generalist feeders, while the hadal snailfishes were exclusively predators. With increasing depth, predation was found to increase while scavenging decreased. The data suggest scavenging fish fauna do not extend deeper than the hadal boundary.

Developing a Framework and Priorities to Promote Mobility among Older Adults

ERIC Educational Resources Information Center

Anderson, Lynda A.; Slonim, Amy; Yen, Irene H.; Jones, Dina L.; Allen, Peg; Hunter, Rebecca H.; Goins, R. Turner; Leith, Katherine H.; Rosenberg, Dori; Satariano, William A.; McPhillips-Tangum, Carol

2014-01-01

Mobility, broadly defined as movement in all of its forms from ambulation to transportation, is critical to supporting optimal aging. This article describes two projects to develop a framework and a set of priority actions designed to promote mobility among community-dwelling older adults. Project 1 involved a concept-mapping process to solicit…

An Introduction to Replication Research in Gifted Education: Shiny and New Is Not the Same as Useful

ERIC Educational Resources Information Center

Makel, Matthew C.; Plucker, Jonathan A.

2015-01-01

This methodological brief introduces readers to replication methods and their uses. Broadly defined, replication is the duplication of previously conducted research to verify or expand the original findings. Replication is particularly useful in the gifted education context because so much education theory and research are based on general…

Surveys of Ph.D. Thesis: Review of Doctoral Research in Language Assessment in Canada (2006-2011)

ERIC Educational Resources Information Center

Cheng, Liying; Fox, Janna

2013-01-01

This paper reviews a selected sample of 24 doctoral dissertations in language assessment (broadly defined), completed between 2006 and 2011 in Canadian universities. These dissertations fall into five thematic categories: 1) reliability, validity and factors affecting test performance; 2) washback (impact) and ethics; 3) raters, rating and rating…

Beyond Self-Esteem: Some Neglected Aspects of the Self-Concept.

ERIC Educational Resources Information Center

Rosenberg, Morris

The purpose of this paper is to call attention to certain important aspects of self-concept which have been largely neglected in behavioral science research literature. Self-concept is defined as the totality of the individual's thoughts and feelings with reference to himself as an object. Three broad areas of self-concept are discussed. The first…

Development of diagnostic markers from disease resistance QTLs for marker-assisted breeding in peanut

USDA-ARS?s Scientific Manuscript database

Breeding for disease resistance in peanut cultivars has been constrained due to both a narrow genetic base and a low degree of polymorphism. Earlier attempts have resulted in the development of a few hundreds of simple sequence repeat (SSR) markers in peanut that could define broad QTL on the physic...

The Arizona Riparian Area Advisory Committee: An experience in defining desired conditions

Treesearch

K. E. Randall

1996-01-01

Created in 1992 by the Arizona Legislature, the Riparian Area Advisory Committee (RAAC) developed recommendations for protecting, maintaining, and restoring riparian areas in Arizona. These recommendations were submitted to the Legislature and to the Governor after concluding a two year period of study and discussion. The RAAC, consisting of 34 members broadly...

Public Choices, Private Costs: An Analysis of Spending and Achievement in Ohio Public Schools.

ERIC Educational Resources Information Center

Damask, James; Lawson, Robert

This report sets up a structure for examining the real costs of public education. It defines three approaches of gathering and reporting cost information: narrow (salaries and current expenditures, excluding capital outlays); generally accepted accounting principles (GAAP) (costs are recorded during the period in which they occur); and broad (all…

Restoration of midwestern oak woodlands and savannas

Treesearch

Dan C. Dey; John M. Kabrick

2015-01-01

There are various definitions for savanna and woodland in the ecological literature. Characteristic elements of each community are broadly defined and often overlap according to the authorities (Curtis 1959; Nuzzo 1986; Nelson 2010). Some confusion is inevitable when categorizing what is in reality a continuum of states from prairie to forest in which there can be much...

Pathways to Improvement: Using Psychological Strategies to Help College Students Master Developmental Math

ERIC Educational Resources Information Center

Silva, Elena; White, Taylor

2013-01-01

Drawing on a research base developed over many years in education, Carnegie is testing a set of strategies to help students persist and succeed academically. This kind of persistence, what the researchers and faculty who developed the Pathways call "productive persistence," is a key driver of Quantway® and Statway®. Broadly defined,…

Goal Attainment Scaling as an Effective Strategy to Assess the Outcomes of Mentoring Programs for Troubled Youth

ERIC Educational Resources Information Center

Balcazar, Fabricio E.; Davies, Gethin L.; Viggers, Dave; Tranter, Gary

2006-01-01

Mentoring programs are increasingly popular as preventive and/or supportive interventions for youth with various needs. A meta-analysis of mentoring program effects conducted by DuBois, Holloway, Valentine, and Cooper (2002) suggests that youth from backgrounds of risk (defined broadly) have the capacity to benefit from mentoring, especially when…

Problems in Defining the Direction and Content of International Education for the 21st Century.

ERIC Educational Resources Information Center

Beltsos, Nicholas J.

A discussion of international education in the 21st century begins with the premise that international education is an extension of domestic education adapted to emerging global interdependence. Prevailing public and academic debates on the issue are reviewed, focusing on the relationship between education and training. A broad picture of the…

ASSOCIATIONS AMONG CATCHMENT- AND SITE-SCALE DISTURBANCE INDICATORS AND BIOLOGICAL ASSEMBLAGES AT LEAST- AND MOST-DISTURBED STREAM AND RIVER SITES IN THE WESTERN UNITED STATES

EPA Science Inventory

At broad scales, the types and intensities of human disturbances to ecosystems vary along natural gradients. Biological assemblages also vary with natural and human disturbance gradients. We defined least-disturbed conditions for a set of water chemistry, catchment, and site-sc...

Habitat networks for terrestrial wildlife: concepts and case studies

Treesearch

Mary M. Rowland; Michael J. Wisdom

2008-01-01

Species of conservation concern, which we define as species with rare or declining populations or habitats, often number in the hundreds or even thousands within a given ecosystem. Moreover, these species typically span a wide spectrum of taxa and are associated with a broad set of ecological characteristics and diverse management challenges. Management designed to...

26 CFR 1.509(a)-3T - Broadly, publicly supported organizations (temporary).

Code of Federal Regulations, 2010 CFR

2010-04-01

... TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Private Foundations § 1.509(a)-3T...) distinguishes gross receipts from gross investment income. (3) Not-more-than-one-third support test—(i) In...-third of its support in each taxable year from the sum of its gross investment income (as defined in...

Predicting Writing Development in Dual Language Instructional Contexts: Exploring Cross-Linguistic Relationships

ERIC Educational Resources Information Center

Savage, Robert; Kozakewich, Meagan; Genesee, Fred; Erdos, Caroline; Haigh, Corinne

2017-01-01

This study examined whether decoding and linguistic comprehension abilities, broadly defined by the Simple View of Reading, in grade 1 each uniquely predicted the grade 6 writing performance of English-speaking children (n = 76) who were educated bilingually in both English their first language and French, a second language. Prediction was made…

REPORT OF FINDINGS AND RESULTS OF TECHNICAL EDUCATION CURRICULUM WORKSHOP (LOS ALAMOS, NEW MEXICO, AUGUST 7-11, 1967).

ERIC Educational Resources Information Center

HARDWICK, ARTHUR LEE

AT THIS WORKSHOP OF INDUSTRIAL REPRESENTATIVE AND TECHNICAL EDUCATORS, A TECHNICIAN WAS DEFINED AS ONE WITH BROAD-BASED MATHEMATICAL AND SCIENTIFIC TRAINING AND WITH COMPETENCE TO SUPPORT PROFESSIONAL SYSTEMS, ENGINEERING, AND OTHER SCIENTIFIC PERSONNEL. HE SHOULD RECEIVE A RIGOROUS, 2-YEAR, POST SECONDARY EDUCATION ESPECIALLY DESIGNED FOR HIS…

Assessing the Impact of Short-Term Study Abroad on L2 Learners' Attitudes towards Spanish

ERIC Educational Resources Information Center

Artamonova, Tatiana

2017-01-01

Language attitudes, a multifaceted construct, can be broadly defined as evaluative views of a language and other relevant entities, including its speakers and associated cultures. Language attitudes are influential in second language (L2) acquisition as they relate to language learning motivation and achievement, perseverance in language study,…

Shaping the College Curriculum: Academic Plans in Action.

ERIC Educational Resources Information Center

Stark, Joan S.; Lattuca, Lisa R.

This book proposes a broad view of the college curriculum, suggesting that it be defined as an "academic plan." The plan included decisions about what, why, and how students learn; ways to determine whether students have learned what they are supposed to learn; and methods of using this information to improve the plan. Taking both a macro and a…

A Symbiotic Relationship? Exploring the Relationships between College Students and Community Partners Who Engage in a Shared Service-Learning Project

ERIC Educational Resources Information Center

Budhai, Stephanie Smith

2012-01-01

Broadly defined as the combination and/or integration of participation in a community service activity with formal learning and reflection (Clark, 1999; Reising, Allen, & Hall, 2006; Tucker, McCarthy, & Lenk, 1998; Yan & Rodgers, 2006), service-learning activities range from voluntary student organized initiatives to mandatory…

When We Review the National Visual Arts Standards

ERIC Educational Resources Information Center

Herberholz, Barbara

2010-01-01

The National Art Education Association (NAEA) has clearly defined the role of art with six content and achievement standards that are broad in coverage and designed specifically to ensure a thorough and comprehensive art program for K-4, 5-8 and 9-12. To meet the standards, students learn vocabularies and concepts associated with various types of…

Sexual and Reproductive Health Information Sources Preferred by Out-of-School Adolescents in Rural Southwest Uganda

ERIC Educational Resources Information Center

Nobelius, Ann-Maree; Kalina, Bessie; Pool, Robert; Whitworth, Jimmy; Chesters, Janice; Power, Robert

2010-01-01

This paper defines how out-of-school adolescents from Masaka District in rural southwest Uganda currently receive sexual and reproductive health information and how they would prefer to receive that information. Information adolescents feel they lack falls into three broad categories: sexual and reproductive health issues, the negotiation of sex…

Words in Action. 1996 Annual Report. Southern Education Foundation, Inc.

ERIC Educational Resources Information Center

Southern Education Foundation, Atlanta, GA.

This annual report defines three broad areas in which the Southern Education Foundation supports research. The first looks to what kinds of teachers will be needed in the future; the second asks how our best thinking can be translated into effective action; and the third asks how seamless education can be. Programs subsumed under education and…

Teaching Elementary Mathematics through Problem Solving and Its Relationship to Mathematics Achievement

ERIC Educational Resources Information Center

Bullock, Audrey N.

2017-01-01

Problem solving in mathematics has been a goal for students for decades. In the reviewed literature, problem solving was most often treated as the dependent variable and was defined very broadly; however, few studies were found that included problem solving as a treatment or independent variable. The purpose of this study was to investigate the…

A Goodly Fellowship of Writers and Readers. Concept Paper No. 4.

ERIC Educational Resources Information Center

Lloyd-Jones, Richard

Writing is at the heart of education. The business of English teachers is to make people more comfortable in using language, particularly written language. Language serves two broad functions: (1) representing elements of external reality; and (2) defining relationships among the people who use the language. The writer's first need is to use the…

The {open_quotes}obligation to serve{close_quotes} and a competitive electric industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colton, R.D.

1997-11-01

This report presents an assessment of what the ``obligation to serve`` might look like in a competitive electric industry. Broadly, this research has three objectives: to define the ``duty to serve`` of a competitive electric industry; to identify those companies to whom that duty applies; and to explain how that duty protects residual classes.

Practice Parameter on Child and Adolescent Mental Health Care in Community Systems of Care

ERIC Educational Resources Information Center

Journal of the American Academy of Child and Adolescent Psychiatry, 2007

2007-01-01

This parameter presents overarching principles and practices for child and adolescent mental health care in community systems of care. Community systems of care are defined broadly as comprising the wide array of child-serving agencies, programs, and practitioners (both public and private), in addition to natural community supports such as…

Assessing the expected effects of wildfire on vegetation condition on the Bridger-Teton National Forest, Wyoming, USA

Treesearch

J. H. Scott; D. J. Helmbrecht; M. P. Thompson

2014-01-01

Characterizing wildfire risk to a fire-adapted ecosystem presents particular challenges due to its broad spatial extent, inherent complexity, and the difficulty in defining wildfire-induced losses and benefits. Our approach couples stochastic wildfire simulation with a vegetation condition assessment framework to estimate the conditional and expected response of...

Does the Center Hold? Reflections on a Sociological Core

ERIC Educational Resources Information Center

Ballantine, Jeanne; Greenwood, Nancy; Howard, Jay R.; Kain, Edward L.; Pike, Diane; Schwartz, Michael; Smith, R. Tyson; Zipp, John F.

2016-01-01

Is there a distinct disciplinary core (or foundation of agreed on knowledge) in sociology? Should we define a core in our broad field to build consensus? If so, what should it look like? We address these questions by presenting three viewpoints that lean for and against identifying a core for department curricula, students, and the public face of…

Racial-Ethnic Identity, Academic Achievement, and African American Males: A Review of Literature

ERIC Educational Resources Information Center

Wright, Brian L.

2009-01-01

This article discusses broadly, the literature on racial-ethnic identity (REI) and its role as a factor to promote academic success in young African American adolescents, in particular males. The review also defines, describes, and interprets styles of self-presentation that reflect aspects of REI among African American males in and outside of…

Introducing LangCrit: Critical Language and Race Theory

ERIC Educational Resources Information Center

Crump, Alison

2014-01-01

Teachers of English to Speakers of Other Languages (TESOL) scholars have recently drawn on critical race theory (CRT) to critique and understand the propagation of Whiteness as a norm associated with native English speakers. However, the area of language studies, more broadly defined, has yet to develop the same link with CRT. To this end, this…

Counting all that matters: recognizing the value of ecosystem services.

Treesearch

Sussane Maleki

2008-01-01

Broadly defined, ecosystem services are the benefits healthy ecosystems provide to humans. Clean air, clean water, and flood control are just a few examples. Although the term is relatively new, the ecosystem services concept has long been a focus of natural resource and environmental economists. As the U.S. population increases and the forests and grasslands that...

Site-improving intercrops for black walnut

Treesearch

J.W. Van Sambeek

1988-01-01

Broadly defined, intercropping of black walnut (Juglans nigra L.) refers to the production of one or more additional crops for food and/or fiber during all or part of the walnut rotation. lntercropping of walnut has been proposed for two main reasons: (1) to increase growth and/or quality of the walnut trees or (2) to provide an early financial...

Nanotechnology for the forest products industry: vision and technology roadmap

Treesearch

Inc. Atlanta Prepared by Energetics

2005-01-01

Nanotechnology is defined as the manipulation of materials measuring 100 nanometers or less in at least one dimension. Nanotechnology is expected to be a critical driver of global economic growth and development in this century. Already, this broad multi-disciplinary field is providing glimpses of exciting new capabilities, enabling materials, devices, and systems that...

Looking for Meaning in All the Wrong Places: Why Negative Advertising Is a Suspect Category.

ERIC Educational Resources Information Center

Richardson, Glenn W., Jr.

2001-01-01

Presents a critical review of academic work on negativity in political advertising that shows that the concept has been defined in ways that are too broad, insufficiently holistic, and too pejorative. Suggests exploratory data indicate that the component parts of negativity are: misleading claims, emotional appeals, one-sided attacks, and a…

Understanding How Programs Work to Prevent Overt Aggressive Behaviors: A Meta-Analysis of Mediators of Elementary School-Based Programs

ERIC Educational Resources Information Center

Dymnicki, Allison B.; Weissberg, Roger P.; Henry, David B.

2011-01-01

Several recent meta-analyses of universal school-based violence prevention studies indicate the overall positive impacts of these approaches on aggression. These studies, however, assess impacts on broadly defined measures of aggression. Furthermore, little research has analyzed the mechanisms through which these programs attempt to reduce overt…

Acceptability and Efficacy of Locally Produced Ready-to-Use Therapeutic Food Nutreal in the Management of Severe Acute Malnutrition in Comparison With Defined Food.

PubMed

Thapa, Babu Ram; Goyal, Pooja; Menon, Jagadeesh; Sharma, Ajay

2017-01-01

Severe acute malnutrition (SAM) is a salient health problem in India. Federation of Indian Chamber of Commerce and Industry (FICCI) Research and Analysis Centre, New Delhi, prepared nutreal equivalent to ready-to-use therapeutic food by World Health Organization (WHO) for the management of SAM and defined food like homemade diet. To compare acceptability and efficacy of nutreal over defined food for the management of SAM. One hundred twelve children aged less than 5 years with SAM were enrolled as per the standard of WHO. Children were randomized into 2 groups to receive nutreal (n = 56) and defined food (n = 56) in unlimited amounts for 42 consecutive days and extended by 2 weeks as per demand. Calorie and protein intake, weight, and mid-upper arm circumference (MUAC) were recorded daily. Age range was 8 to 45 months. Ninety-three percent of children eagerly accepted nutreal but 7% does not. Whereas in the defined food group, 68% accepted eagerly, 30% did not accept eagerly, and 1.8% accepted poorly ( P = .004). At enrollment, mean weight in the nutreal group was 6.44 ± 1.60 kg and in the defined food group was 8.69 ± 1.76 kg, with MUAC in the nutreal group being 11.12 ± 0.47 cm and in the defined food group being 11.54 ± 0.34 cm. Mean weight in the nutreal and defined food groups at eighth week of intervention was 7.97 ± 1.8 kg and 9.71 ± 1.8 kg ( P < .001), respectively. Mid-upper arm circumference at eighth week was 12.10 ± 0.29 cm in the nutreal group and 12.49 ± 0.50 cm in the defined group ( P < .001). Acceptability, mean weight gain, and MUAC in the nutreal group are greater than the defined food.

Sociality and health: impacts of sociality on disease susceptibility and transmission in animal and human societies

PubMed Central

Kappeler, Peter M.; Cremer, Sylvia; Nunn, Charles L.

2015-01-01

This paper introduces a theme issue presenting the latest developments in research on the impacts of sociality on health and fitness. The articles that follow cover research on societies ranging from insects to humans. Variation in measures of fitness (i.e. survival and reproduction) has been linked to various aspects of sociality in humans and animals alike, and variability in individual health and condition has been recognized as a key mediator of these relationships. Viewed from a broad evolutionary perspective, the evolutionary transitions from a solitary lifestyle to group living have resulted in several new health-related costs and benefits of sociality. Social transmission of parasites within groups represents a major cost of group living, but some behavioural mechanisms, such as grooming, have evolved repeatedly to reduce this cost. Group living also has created novel costs in terms of altered susceptibility to infectious and non-infectious disease as a result of the unavoidable physiological consequences of social competition and integration, which are partly alleviated by social buffering in some vertebrates. Here, we define the relevant aspects of sociality, summarize their health-related costs and benefits, and discuss possible fitness measures in different study systems. Given the pervasive effects of social factors on health and fitness, we propose a synthesis of existing conceptual approaches in disease ecology, ecological immunology and behavioural neurosciences by adding sociality as a key factor, with the goal to generate a broader framework for organismal integration of health-related research. PMID:25870402

Reduction mammoplasty operative techniques for improved outcomes in the treatment of gigantomastia.

PubMed

Degeorge, Brent R; Colen, David L; Mericli, Alexander F; Drake, David B

2013-01-01

Gigantomastia, or excessive breast hypertrophy, which is broadly defined as macromastia requiring a surgical reduction of more than 1500 g of breast tissue per breast, poses a unique problem to the reconstructive surgeon. Various procedures have been described for reduction mammoplasty with specific skin incisions, patterns of breast parenchymal resection, and blood supply to the nipple-areolar complex; however, not all of these techniques can be directly applied in the setting of gigantomastia. We outline a simplified method for preoperative evaluation and operative technique, which has been optimized for the management of gigantomastia. A retrospective chart review of patients who have undergone reduction mammoplasty from 2006 to 2011 by a single surgeon at the University of Virginia was performed. Patients were subdivided based on weight of breast tissue resection into 2 groups: macromastia (<1500 g resection per breast) and gigantomastia (>1500 g resection per breast). Endpoints including patient demographics, operative techniques, and complication rates were recorded. The mean resection weights in the macromastia and gigantomastia groups, respectively, were 681 g ± 283 g and 2554 g ± 421 g. There were no differences in major complications between the 2 groups. The rate of free nipple graft utilization was not significantly different between the 2 groups. Our surgical approach to gigantomastia has advantages when applied to extremely large-volume breast reduction and provides both esthetic and reproducible results. The preoperative assessment and operative techniques described herein have been adapted to the management of gigantomastia to reduce the rates of surgical complications.

Isopermutation group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muktibodh, A. S.

2015-03-10

The concept of ‘Isotopy’ as formulated by Ruggero Maria Santilli [1, 2, 3] plays a vital role in the development of Iso mathematics. Santilli defined iso-fields of characteristic zero. In this paper we extend this definition to define Iso-Galois fields [4] which are essentially of non-zero characteristic. Isotopically isomorphic realizations of a group define isopermutation group which gives a clear cut distinction between automorphic groups and isotopic groups.

The effects of video-game training on broad cognitive transfer in multiple sclerosis: A pilot randomized controlled trial.

PubMed

Janssen, Alisha; Boster, Aaron; Lee, HyunKyu; Patterson, Beth; Prakash, Ruchika Shaurya

2015-01-01

Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system that results in diffuse nerve damage and associated physical and cognitive impairments. Of the few comprehensive rehabilitation options that exist for populations with lower baseline cognitive functioning, those that have been successful at eliciting broad cognitive improvements have focused on a multimodal training approach, emphasizing complex cognitive processing that utilizes multiple domains simultaneously. The current study sought to determine the feasibility of an 8-week, hybrid-variable priority training (HVT) program, with a secondary aim to assess the success of this training paradigm at eliciting broad cognitive transfer effects. Capitalizing on the multimodal training modalities offered by the Space Fortress platform, we compared the HVT strategy-based intervention with a waitlist control group, to primarily assess skill acquisition and secondarily determine presence of cognitive transfer. Twenty-eight participants met inclusionary criteria for the study and were randomized to either training or waitlist control groups. To assess broad transfer effects, a battery of neuropsychological tests was administered pre- and post-intervention. The results indicated an overall improvement in skill acquisition and evidence for the feasibility of the intervention, but a lack of broad transfer to tasks of cognitive functioning. Participants in the training group, however, did show improvements on a measure of spatial short-term memory. The current investigation provided support for the feasibility of a multimodal training approach, using the HVT strategy, within the MS population, but lacked broad transfer to multiple domains of cognitive functioning. Future improvements to obtain greater cognitive transfer efficacy would include a larger sample size, a longer course of training to evoke greater game score improvement, the inclusion of only cognitively impaired individuals, and integration of subjective measures of improvement in addition to objective tests of cognitive performance.

Broad spectrum anthelmintic resistance of Haemonchus contortus in Northern NSW of Australia.

PubMed

Lamb, Jane; Elliott, Tim; Chambers, Michael; Chick, Bruce

2017-07-15

On a sheep farm in Northern New South Wales (NSW) of Australia a degree of anthelmintic resistance was suspected. With noticeable clinical signs of infection and sheep not responding to treatment, a faecal egg count reduction test was conducted to ascertain the broad spectrum of anthelmintic resistance at this farm. A number of classes of anthelmintics were assessed including organophosphate, macrocyclic lactone (ML) and in combination an ML, benzimidazole, levamisole and salicylanilide. In addition, the more recently registered classes of anthelmintics, monepantel (amino-acetonitrile derivative) and derquantel/abamectin combination (spiroindole+ML) were included. Ninety merino sheep naturally infected with a field strain of Haemonchus contortus were randomly allocated to 6 treatment groups (15 animals/group). Sheep were subsequently treated based on label recommendations and individual bodyweight. Faecal samples were collected post-treatment on Days 7, 14 and 21 to conduct faecal egg counts and group bulk larval cultures. Broad spectrum anthelmintic resistance was confirmed at this site with treatment efficacies ranging from 21.3% (monepantel) to 93.8% (derquantel/abamectin combination) against the H. contortus strain. Furthermore, resistance to the multi-combination anthelmintic containing 4 active ingredients was evident (52.5%). This broad spectrum of resistance highlights the need for integration of alternative sustainable methods in parasite control in order to slow development of resistance and increase the life time effectiveness of anthelmintics. Copyright © 2017 Elsevier B.V. All rights reserved.

Photosynthetic light capture and processing from cell to canopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stenberg, P.; DeLucia, E.H.; Schoettle, A.W.

1995-07-01

We have addressed the unique structural features of conifers, as they relate to photosynthetic production, at different levels of organization (from needle to canopy). Many concepts and measures must be defined for conifers so that they are consistent with the structural properties of needles and shoots. Consistency is needed in comparing the photosynthetic performance of conifers and broad leaves, wherein it is important to distinguish the effect of structural factors on light capture from differences in the photosynthetic response at a fixed interception. Needles differ from broad leaves both with respect to inner structure and external shape, which includes amore » continuum from nearly flat to cylindrical. For nonflat three-dimensional objects such as for conifer needles, total surface area is the natural measure. The meaning of the one-sided area of needles is not clear, but consistency requires that it be defined as half the total needle surface area, as concluded. Characteristic structural factors of conifers that affect their ability to harvest light are a deep canopy combined with a small needle size, which create an important penumbra effect, and the clustering of needles on shoots, which creates a discontinuous distribution of needle area. These factors imply that, at a fixed leaf area index, the intercepted PAR would be smaller in coniferous than in broad-leafed canopies, but the vertical gradient of light in conifers is less steep and light reaching the lower canopy is all penumbral (diffuse). Conifers can maintain a higher leaf area index, and this may be accomplished by a more even distribution of light between shoots at different locations in the canopy and also because shade shoots have a structure that effectively intercepts light. Broad leaves in general have higher maximum photosynthetic rates than do needles, and yet conifers are at least equally productive on a stand basis. Possible reasons are discussed.« less

Deuteron spin-lattice relaxation in the presence of an activation energy distribution: application to methanols in zeolite NaX.

PubMed

Stoch, G; Ylinen, E E; Birczynski, A; Lalowicz, Z T; Góra-Marek, K; Punkkinen, M

2013-02-01

A new method is introduced for analyzing deuteron spin-lattice relaxation in molecular systems with a broad distribution of activation energies and correlation times. In such samples the magnetization recovery is strongly non-exponential but can be fitted quite accurately by three exponentials. The considered system may consist of molecular groups with different mobility. For each group a Gaussian distribution of the activation energy is introduced. By assuming for every subsystem three parameters: the mean activation energy E(0), the distribution width σ and the pre-exponential factor τ(0) for the Arrhenius equation defining the correlation time, the relaxation rate is calculated for every part of the distribution. Experiment-based limiting values allow the grouping of the rates into three classes. For each class the relaxation rate and weight is calculated and compared with experiment. The parameters E(0), σ and τ(0) are determined iteratively by repeating the whole cycle many times. The temperature dependence of the deuteron relaxation was observed in three samples containing CD(3)OH (200% and 100% loading) and CD(3)OD (200%) in NaX zeolite and analyzed by the described method between 20K and 170K. The obtained parameters, equal for all the three samples, characterize the methyl and hydroxyl mobilities of the methanol molecules at two different locations. Copyright © 2012 Elsevier Inc. All rights reserved.