Science.gov

Sample records for brothers big sisters

  1. Mentoring in Schools: An Impact Study of Big Brothers Big Sisters School-Based Mentoring

    ERIC Educational Resources Information Center

    Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; McMaken, Jennifer

    2011-01-01

    This random assignment impact study of Big Brothers Big Sisters School-Based Mentoring involved 1,139 9- to 16-year-old students in 10 cities nationwide. Youth were randomly assigned to either a treatment group (receiving mentoring) or a control group (receiving no mentoring) and were followed for 1.5 school years. At the end of the first school…

  2. Serving, Learning and Mentoring through the Big Brothers Big Sisters Program

    ERIC Educational Resources Information Center

    Sivukamaran, Thillainatarajan; Holland, Glenda; Clark, Leonard J.

    2010-01-01

    This study describes the collaborative partnership between a Big Brothers Big Sisters organization, an elementary school and the College of Education at a public university. The partnership utilized a mentoring system consisting of elementary students, college students, elementary teachers and university faculty. Benefits of the various…

  3. Untapped Potential: Fulfilling the Promise of Big Brothers Big Sisters and the Bigs and Littles They Represent

    ERIC Educational Resources Information Center

    Bridgeland, John M.; Moore, Laura A.

    2010-01-01

    American children represent a great untapped potential in our country. For many young people, choices are limited and the goal of a productive adulthood is a remote one. This report paints a picture of who these children are, shares their insights and reflections about the barriers they face, and offers ways forward for Big Brothers Big Sisters as…

  4. High School Students as Mentors: Findings from the Big Brothers Big Sisters School-Based Mentoring Impact Study

    ERIC Educational Resources Information Center

    Herrera, Carla; Kauh, Tina J.; Cooney, Siobhan M.; Grossman, Jean Baldwin; McMaken, Jennifer

    2008-01-01

    High schools have recently become a popular source of mentors for school-based mentoring (SBM) programs. The high school Bigs program of Big Brothers Big Sisters of America, for example, currently involves close to 50,000 high-school-aged mentors across the country. While the use of these young mentors has several potential advantages, their age…

  5. An Evaluation of Parental Assessment of the Big Brothers/Big Sisters Program in New York City.

    ERIC Educational Resources Information Center

    Frecknall, Peter; Luks, Alan

    1992-01-01

    Parents rated impact of Big Brother/Big Sister program on children along variables of school attendance, grades, family relationship, friendship, self-esteem, staying out of trouble, being responsible, frequency of contact, and length of time in program. Although children were rated as benefiting significantly from program, children's frequency of…

  6. High School Mentors in Brief: Findings from the Big Brothers Big Sisters School-Based Mentoring Impact Study. P/PV In Brief. Issue 8

    ERIC Educational Resources Information Center

    Jucovy, Linda; Herrera, Carla

    2009-01-01

    This issue of "Public/Private Ventures (P/PV) In Brief" is based on "High School Students as Mentors," a report that examined the efficacy of high school mentors using data from P/PV's large-scale random assignment impact study of Big Brothers Big Sisters school-based mentoring programs. The brief presents an overview of the findings, which…

  7. Are youth mentoring programs good value-for-money? An evaluation of the Big Brothers Big Sisters Melbourne Program.

    PubMed

    Moodie, Marjory L; Fisher, Jane

    2009-01-30

    The Big Brothers Big Sisters (BBBS) program matches vulnerable young people with a trained, supervised adult volunteer as mentor. The young people are typically seriously disadvantaged, with multiple psychosocial problems. Threshold analysis was undertaken to determine whether investment in the program was a worthwhile use of limited public funds. The potential cost savings were based on US estimates of life-time costs associated with high-risk youth who drop out-of-school and become adult criminals. The intervention was modelled for children aged 10-14 years residing in Melbourne in 2004. If the program serviced 2,208 of the most vulnerable young people, it would cost AUD 39.5 M. Assuming 50% were high-risk, the associated costs of their adult criminality would be AUD 3.3 billion. To break even, the program would need to avert high-risk behaviours in only 1.3% (14/1,104) of participants. This indicative evaluation suggests that the BBBS program represents excellent 'value for money'.

  8. When Your Brother or Sister Has Cancer

    Cancer.gov

    Tips on what to say to your friends, how to deal with stress, and where to find support – as well as information about cancer and cancer treatments, for young people who have a brother or sister with cancer.

  9. When Your Brother or Sister Has Cancer

    Cancer.gov

    Help when a brother or sister has cancer. Learn how families cope and find support when a sibling has cancer. Tips to help you talk with your friends, deal with stress, and take care of your mind and body are also shared.

  10. Brothers and Sisters: A Source of Support for Children in School?

    ERIC Educational Resources Information Center

    Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie

    2006-01-01

    Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and sisters becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers…

  11. One sister and brother with mirror image myopic anisometropia.

    PubMed

    Park, Sung Joon; Kim, Joo Yeon; Baek, Seung-Hee; Kim, Eung Suk; Kim, Ungsoo S

    2010-02-01

    We report a case of one sister and brother with mirror image myopic anisometropia. One sister and brother complained visual disturbance. The sister was 10 years 11 months old, and brother was 8 years 4 months old. Full ophthalmic examinations were performed, including slit lamp examination, intraocular pressure, keratometry, anterior chamber depth, axial length, fundus examination and the cycloplegic refraction. The cycloplegic refractive power was -15.50 dpt cyl.+4.50 dpt Ax 85 degrees (right eye), -1.00 dpt cyl.+0.50 dpt Ax 90 degrees (left eye) in the sister; -1.75 dpt cyl.+2.25 dpt Ax 90 degrees (right eye), -9.50 dpt cyl.+4.00 dpt Ax 80 degrees (left eye) in the brother. The co-occurrence of severe myopic anisometropia in a sister and brother is extremely rare. The present case suggests that severe myopic anisometropia may be related by genetic inheritance.

  12. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    ERIC Educational Resources Information Center

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  13. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    ERIC Educational Resources Information Center

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  14. Freud on Brothers and Sisters: A Neglected Topic

    ERIC Educational Resources Information Center

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  15. Freud on Brothers and Sisters: A Neglected Topic

    ERIC Educational Resources Information Center

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  16. Adult Sibling Relationships with Brothers and Sisters with Severe Disabilities

    ERIC Educational Resources Information Center

    Rossetti, Zach; Hall, Sarah

    2015-01-01

    The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or sister with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…

  17. Adult Sibling Relationships with Brothers and Sisters with Severe Disabilities

    ERIC Educational Resources Information Center

    Rossetti, Zach; Hall, Sarah

    2015-01-01

    The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or sister with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…

  18. Paternity testing in case of brother-sister incest.

    PubMed

    Macan, Marijana; Uvodić, Petra; Botica, Vladimir

    2003-06-01

    We performed a paternity test in a case of incest between brother and sister. DNA from blood samples of the alleged parents and their two children was obtained with Chelex DNA extraction method and quantified with Applied Biosystems QuantiBlot quantitation kit. Polymerase chain reaction (PCR) amplification of DNA samples was performed with AmpFlSTR SGM Plus PCR amplification kit and GenePrint PowerPlex PCR amplification kit. The amplified products were separated and detected by using the Perkin Elmer's ABI PRISM trade mark 310 Genetic Analyser. DNA and data analysis of 17 loci and Amelogenin confirmed the suspicion of brother-sister incest. Since both children had inherited all of the obligate alleles from the alleged father, we could confirm with certainty of 99.999999% that the oldest brother in the family was the biological father of both children. Calculated data showed that even in a case of brother-sister incest, paternity could be proved by the analysis of Amelogenin and 17 DNA loci.

  19. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  20. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  1. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  2. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  3. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  4. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  5. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  6. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  7. 20 CFR 410.215 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or sister. (a) parent, brother, or sister is entitled to benefits beginning with the month all...

  8. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  9. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  10. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  11. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  12. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  13. 20 CFR 410.215 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or sister. (a) parent, brother, or sister is entitled to benefits beginning with the month all...

  14. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  15. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  16. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  17. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  18. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  19. Mothers' differential treatment of adolescent siblings: predicting college attendance of sisters versus brothers.

    PubMed

    Bissell-Havran, Joanna M; Loken, Eric; McHale, Susan M

    2012-10-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We examined whether the difference between sisters' and brothers' reports of their mothers' expectations for, and involvement in, their education during adolescence predicted their differential odds of college attendance seven years later. Sisters were more likely than brothers to attend college, and this gap was more pronounced among non-Whites and non-Asians. Sisters also had higher grades in school than their brothers. Although there were no gender differences overall in maternal educational expectations or involvement, brothers reported greater maternal involvement than sisters in non-White and non-Asian families. After controlling for family background factors, the average of siblings' reports of maternal treatment, and differences between siblings' grades, the results revealed that as sisters reported greater maternal educational expectations than their brothers, it became more likely that only the sister rather than only the brother in the family attended college. The difference between brothers' and sisters' reports of their mothers' educational involvement and their odds of attending college showed the same pattern of association but was not statistically significant. These results suggest that within-family social comparisons may play a role in sisters' and brothers' choices about attending college.

  20. Having a Brother or Sister with Down Syndrome: Perspectives from Siblings

    PubMed Central

    Skotko, Brian G.; Levine, Susan P.; Goldstein, Richard

    2012-01-01

    This study asks brothers and sisters about their feelings and perceptions toward their sibling with Down syndrome. We analyzed valid and reliable surveys from 822 brothers and sisters whose families were on the mailing lists of six non-profit Down syndrome organizations around the country. More than 96% of brothers/sisters that responded to the survey indicated that they had affection toward their sibling with Down syndrome; and 94% of older siblings expressed feelings of pride. Less than 10% felt embarrassed, and less than 5% expressed a desire to trade their sibling in for another brother or sister without Down syndrome. Among older siblings, 88% felt that they were better people because of their siblings with Down syndrome, and more than 90% plan to remain involved in their sibling’s lives as they become adults. The vast majority of brothers and sisters describe their relationship with their sibling with Down syndrome as positive and enriching. PMID:21910244

  1. The role of brothers and sisters in the gender development of preschool children.

    PubMed

    Rust, J; Golombok, S; Hines, M; Johnston, K; Golding, J

    2000-12-01

    The study examined whether the sex of older siblings influences the gender role development of younger brothers and sisters of age 3 years. Data on the Pre-School Activities Inventory, a measure of gender role behavior that discriminates within as well as between the sexes, were obtained in a general population study for 527 girls and 582 boys with an older sister, 500 girls and 561 boys with an older brother, and 1665 singleton girls and 1707 singleton boys. It was found that boys with older brothers and girls with older sisters were more sex-typed than same-sex singletons who, in turn, were more sex-typed than children with other-sex siblings. Having an older brother was associated with more masculine and less feminine behavior in both boys and girls, whereas boys with older sisters were more feminine but not less masculine and girls with older sisters were less masculine but not more feminine.

  2. Living with a Brother Who Has an Autism Spectrum Disorder: A Sister's Perspective

    ERIC Educational Resources Information Center

    Connell, Zara O.; Halloran, Maeve O.; Doody, Owen

    2016-01-01

    People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or sister. Services for people with ASD should provide effective support to families, which include brothers,…

  3. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother, or sister. An individual is entitled to benefits if: (a) Such individual: (1) Is the parent,...

  4. Catholic nursing sisters and brothers and racial justice in mid-20th-century America.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing's work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses' work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of "bearing witness," a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely.

  5. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  6. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  7. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  8. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  9. Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and Sisters, and Nonclinical Controls.

    ERIC Educational Resources Information Center

    Madan-Swain, Avi; And Others

    1993-01-01

    Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and sisters (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…

  10. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    ERIC Educational Resources Information Center

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  11. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    ERIC Educational Resources Information Center

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  12. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  13. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  14. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  15. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  16. "Brothers and Sisters": A Novel Way to Teach Human Resources Management.

    ERIC Educational Resources Information Center

    Bumpus, Minnette

    2000-01-01

    The novel "Brothers and Sisters" by Bebe Moore Campbell was used in a management course to explore human resource management issues, concepts, and theories. The course included prereading and postreading surveys, lecture, book review, and examination. Most of the students (92%) felt the novel was an appropriate way to meet course…

  17. Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and Sisters, and Nonclinical Controls.

    ERIC Educational Resources Information Center

    Madan-Swain, Avi; And Others

    1993-01-01

    Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and sisters (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…

  18. Brother-sister incest - father-daughter incest: a comparison of characteristics and consequences.

    PubMed

    Rudd, J M; Herzberger, S D

    1999-09-01

    One group of women who were sexually abused by brothers and a second group who were sexually abused by fathers are compared with the intent to identify the differing characteristics of each type of abuse and the effects of the abuse on their adult functioning. Our hypothesis was that there would indeed be differences in the characteristics of the abuse and its effects, and that this would necessitate differing treatment strategies. Surveys were distributed to women attending support groups for incest survivors. Of the 62 women completing questionnaires, 14 women (23%) had been sexually abused by a brother. A similar number of women (15) who had been sexually abused by their fathers were chosen from the overall sample for comparison. The absence of the father as a vital force in family life played a key role in the sexual abuse of women by their brothers in every case. The duration of the sexual abuse for brother-abused women and father-abused women was lengthy. The characteristics, including use of force, are equally as serious for sisters as for daughters. The family circumstances surrounding the abuse were examined for both groups and the results yielded a fuller understanding of the incestuous family. Despite an appearance of normalcy, the level of family-wide disturbances, for example substance abuse, mental illness and pervasive family-wide violence were profound for both groups. In this study, we also examine the effects in adulthood of the serious disruption of childhood developmental phases for both brother-abused and father-abused women, taking into account the incidence of substance abuse, depression, suicidality, and eating disorders. The authors conclude that the characteristics and consequences of brother-sister incest are of equal seriousness to those of father-daughter incest. This would suggest that brother-sister incest is one of the current blind spots in incest research, and one that we cannot afford to ignore. In-depth knowledge of the dynamics

  19. Brother-sister incest: data from anonymous computer-assisted self interviews.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Beard, Keith W; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The other 1,230 served as controls. The victims of brother-sister incest had significantly more problematic outcomes than controls on many measures (e.g., more likely than the controls to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). However, victims of brother-sister incest also had significantly less problematic outcomes than victims of father-daughter incest on some measures (e.g., significantly less likely than the father-daughter incest victims to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse).

  20. Catholic Nursing Sisters and Brothers and Racial Justice in Mid-20th-Century America

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224

  1. Perceptions of "Big Sisters" and Their "Little Sisters" Regarding Mentoring Relationships

    ERIC Educational Resources Information Center

    Quarles, Alice; Maldonado, Nancy L.; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    This qualitative study explored the relationships between six Little Sisters (mentees) and their Big Sisters (mentors) to develop an understanding of the perceptions of high-risk adolescent female mentees and their mentors regarding their mentoring relationships. Participants were purposefully selected--those actively involved in a formal…

  2. Siblings' experiences of their brother's or sister's cancer death: a nationwide follow-up 2-9 years later.

    PubMed

    Lövgren, Malin; Jalmsell, Li; Eilegård Wallin, Alexandra; Steineck, Gunnar; Kreicbergs, Ulrika

    2016-04-01

    The aim of this study was to examine siblings' experiences of their brother's or sister's cancer death and if these experiences influenced levels of anxiety 2-9 years later. This nationwide survey was conducted in Sweden in 2009. All siblings who had a brother/sister who was diagnosed with cancer before the age of 17 years and who died before the age of 25 years during 2000-2007 were invited. Of those, 174 siblings participated (participation rate: 73%). Mixed data from the survey about the siblings' experiences of death were included as well as data from the Hospital Anxiety and Depression Scale. To examine the experiences, descriptive statistics and content analysis were used. Mann-Whitney U-test was conducted to investigate if the experiences influenced anxiety 2-9 years later. The siblings reported poor knowledge and experienced a lack of communication about their brother's/sister's death, for example, about the time frame, bodily changes near death, and about their own experiences. Siblings who reported that no one talked with them about what to expect when their brother/sister was going to die reported higher levels of anxiety 2-9 years after the loss. Seventy percent reported that they witnessed their brother/sister suffering in the last hours in life. Many of those who were not present during the illness period and at the time of death expressed regret. It is important to prepare siblings for their brother's/sister's illness and death as it may decrease anxiety and regrets later on. Copyright © 2015 John Wiley & Sons, Ltd.

  3. Big brothers and little sisters? Sex selection and birth order.

    PubMed

    Salmon, Catherine

    2007-09-01

    Should you be allowed to choose the sex of your child? Even before the advent of modern reproductive technologies, people have expressed interest in producing a child of a specific sex, trying everything from herbal treatments to sexual positions that have been claimed to produce a male or female child. Modern technologies such as flow cytometry make this a realistic possibility but what might the consequences be? In India and China, a preference for male offspring has led (via abortion) to a significant sex-ratio imbalance in those populations. Do other countries express strong preferences for male or female offspring? This article will address the possible birth order implications. Will we live in a world of first-born boys and second-born girls?

  4. Maintenance of Certification: Big Brother or Responsible Regulation?

    PubMed Central

    Rainsberry, R. Paul N.

    1984-01-01

    From a beginning of providing continuing education where there was none, the College of Family Physicians of Canada, in 30 years, has created a system of study credits, a certification process, and now a maintenance of certification process individually tailored to the participant's practice. Every five years certificants can identify learning needs, evaulate the results of a pre- and post-test, and structure a program of continuing education to meet specific needs. They are required only to participate—not to reach a predetermined standard. Few other non-punitive methods can be this specific. The Maintenance of Certification Program is a prevention of the Big Brother syndrome, rather than a manifestation of it. PMID:20469424

  5. Birth order and ratio of brothers to sisters in Spanish transsexuals.

    PubMed

    Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio

    2011-06-01

    Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than sisters. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism.

  6. Challenging stereotypes? The older woman in the TV series Brothers & Sisters.

    PubMed

    Oró-Piqueras, Maricel

    2014-12-01

    The TV series, Brothers & Sisters, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Intrafamilial sexual abuse: brother-sister incest does not differ from father-daughter and stepfather-stepdaughter incest.

    PubMed

    Cyr, Mireille; Wright, John; McDuff, Pierre; Perron, Alain

    2002-09-01

    Three groups of girls who were sexually abused (by either brothers, fathers, or stepfathers) were compared. The purpose was to identify the differing characteristics of the abuse, the family environments, and the psychosocial distress of these children. Seventy-two girls aged between 5 and 16 were assigned to one of the three groups. Subjects were matched between groups on the basis of their actual age. Children completed measures of traumatic stress; their mothers completed the Child Behavior Checklist-Parent Report Form (CBCL) and other self-report questionnaires on family characteristics. Workers in child protective services completed information regarding the nature and severity of the abuse. Results suggested few differences in the characteristics of sexual abuse between the three groups. However, penetration was much more frequent in the sibling incest group (70.8%) than in the stepfather incest (27.3%) or father incest (34.8%) groups. Ninety percent of the victims of fathers and brothers manifested clinically-significant distress on at least one measure, whereas 63.6% of stepfather victims did. Compared with father and stepfather perpetrators, brothers were raised in families with more children and more alcohol abuse. The authors conclude that the characteristics of brother-sister incest and its associated psychosocial distress did not differ from the characteristics of father-daughter incest These findings suggest that theoretical models and clinical practices should be adjusted accordingly and that sibling incest should not necessarily be construed as less severe or harmful than father-daughter incest.

  8. Psychological health in siblings who lost a brother or sister to cancer 2 to 9 years earlier.

    PubMed

    Eilegård, Alexandra; Steineck, Gunnar; Nyberg, Tommy; Kreicbergs, Ulrika

    2013-03-01

    The objective of this study was to assess long-term psychological distress in siblings who lost a brother or sister to cancer 2 to 9 years earlier, as compared with a control group of non-bereaved siblings from the general population. During 2009, we conducted a nationwide follow-up study in Sweden by using an anonymous study-specific questionnaire. Siblings who had lost a brother or sister to cancer between the years 2000 and 2007 and also a control group of non-bereaved siblings from the general population were invited to participate. The Hospital Anxiety and Depression Scale (HADS) was used to measure psychological distress, and to test for differences in the ordinal outcome responses between the groups, we used Wilcoxon-Mann-Whitney rank-sum test. Among the bereaved siblings, 174/240 (73%) participated and 219/293 (75%) among the non-bereaved. Self-assessed low self-esteem (p = 0.002), difficulties falling asleep (p = 0.005), and low level of personal maturity (p = 0.007) at follow-up were more prevalent among bereaved siblings. However, anxiety (p = 0.298) and depression (p = 0.946), according to HADS, were similar. Bereaved siblings are at increased risk of low self-esteem, low level of personal maturity and difficulties falling asleep as compared with non-bereaved peers. Yet, the bereaved were not more likely to report anxiety or depression. Copyright © 2012 John Wiley & Sons, Ltd.

  9. Learning English through Social Interaction: The Case of "Big Brother 2006," Finland

    ERIC Educational Resources Information Center

    Kaanta, Leila; Jauni, Heidi; Leppanen, Sirpa; Peuronen, Saija; Paakkinen, Terhi

    2013-01-01

    In line with recent Conversation Analytic work on language learning as situated practice, this article investigates how interactants can create language learning opportunities for themselves and others in and through social interaction. The study shows how the participants of "Big Brother Finland," a reality TV show, whose main…

  10. Learning English through Social Interaction: The Case of "Big Brother 2006," Finland

    ERIC Educational Resources Information Center

    Kaanta, Leila; Jauni, Heidi; Leppanen, Sirpa; Peuronen, Saija; Paakkinen, Terhi

    2013-01-01

    In line with recent Conversation Analytic work on language learning as situated practice, this article investigates how interactants can create language learning opportunities for themselves and others in and through social interaction. The study shows how the participants of "Big Brother Finland," a reality TV show, whose main…

  11. The consequences of antisocial behavior in older male siblings for younger brothers and sisters.

    PubMed

    Snyder, Jim; Bank, Lew; Burraston, Bert

    2005-12-01

    The contribution of younger male and female siblings' conflict and involvement in deviant activities with their older brothers to younger siblings' adolescent adjustment problems was examined in the context of parenting. Ineffective parenting during younger siblings' childhood had no direct effects on adjustment but facilitated their exposure to older brothers' deviant peers and activities. The effect of sibling conflict on adjustment was mediated by younger siblings' coparticipation in deviant activities with their older brothers during adolescence. Early sibling conflict and coparticipation in deviant activities synergistically increased the risk for younger siblings' adolescent adjustment problems. These empirical relations held in the context of parental discipline of younger siblings during adolescence. Sibling relationships entail a set of iterative social processes that strongly influence risk for adolescent antisocial behavior, drug use, sexual behavior, and traumatic experience. Variations in sibling influence were observed conditional on the gender combination of the sibling pair and on sibling age differences. Copyright 2006 APA, all rights reserved).

  12. Adolescent Siblings of Individuals with and without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings about Their Brothers and Sisters

    ERIC Educational Resources Information Center

    Shivers, Carolyn M.; Dykens, Elisabeth M.

    2017-01-01

    Siblings of brothers or sisters with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward…

  13. Adolescent Siblings of Individuals with and without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings about Their Brothers and Sisters

    ERIC Educational Resources Information Center

    Shivers, Carolyn M.; Dykens, Elisabeth M.

    2017-01-01

    Siblings of brothers or sisters with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward…

  14. A Comparison of Trans Women, Trans Men, Genderqueer Individuals, and Cisgender Brothers and Sisters on the Bem Sex-Role Inventory: Ratings by Self and Siblings.

    PubMed

    Factor, Rhonda J; Rothblum, Esther D

    2017-01-01

    A U.S. national sample of 295 transgender adults (trans women, trans men, and genderqueer individuals) and their cisgender siblings completed the Bem Sex-Role Inventory about their siblings as well as themselves, which enabled a comparison between self-perceptions and sibling's perceptions of personality characteristics. Self-reported personality characteristics scored as feminine of trans women were not statistically different from those of their cisgender sisters, but they were significantly higher than self-reported femininity scores of trans men, genderqueer individuals, and cisgender brothers. Self-reported personality characteristics scored as masculine of trans men did not differ significantly from those of their cisgender brothers, but they were higher than those of trans women. Trans men and cisgender brothers were viewed by their siblings in a more sex-typed way than they rated themselves, whereas trans women and cisgender sisters were rated by their siblings in a less sex-typed way than they viewed themselves.

  15. The influence of big brothers on the separation-individuation of adolescents from single-parent families.

    PubMed

    Saintonge, S; Achille, P A; Lachance, L

    1998-01-01

    The separation-individuation process involving children and their mothers is facilitated by fathers. Divorce complicates this process. This study investigated whether substitute father figures can aid male adolescents from single-parent families with separation-individuation. Twenty-nine adolescents matched to Big Brothers were compared with two control groups (adolescents from single-parent families without Big Brothers and those from intact families) on relevant variables. Findings indicated that the adolescents with Big Brothers were less affected by parental rejection than were adolescents in the two control groups. They also appeared to have healthier narcissism than did adolescents from single-parent families without Big Brothers, but were more anxious when relating to male teachers than were adolescents from intact families.

  16. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., or sister. 410.214 Section 410.214 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL... the pertinent time (see § 410.380); and (4) Files proof of support before June 1, 1974, or within 2... Administration that there is good cause for failure to file such proof within such period (see § 410.216). (b) In...

  17. A resolution recognizing the 100-year anniversary of Big Brothers Big Sisters Southeastern Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2014-12-11

    Senate - 12/11/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  18. A resolution recognizing the 100-year anniversary of Big Brothers Big Sisters Southeastern Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2014-12-11

    12/11/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  19. A brother and sister with breast cancer, BRCA2 mutations and bilateral supernumerary nipples

    PubMed Central

    Coad, Ryan

    2017-01-01

    We describe a 54-year-old man with breast cancer and a BRCA2 mutation who was also found to have bilateral supernumerary nipples. His sister, also with a BRCA2 mutation, was diagnosed with breast cancer in her late forties; she also had bilateral supernumerary nipples. We address the significance of breast cancer arising in breast tissue underlying supernumerary nipples; the known association between supernumerary nipples and genitourinary malignancies/malformations and the possible link between BRCA2 and supernumerary nipple development. We believe that this is the first described case of the latter. We then outline an approach to further management for supernumerary nipple cases. PMID:28361071

  20. Super Mario brothers and sisters: Associations between coplaying video games and sibling conflict and affection.

    PubMed

    Coyne, Sarah M; Jensen, Alexander C; Smith, Nathan J; Erickson, Daniel H

    2016-02-01

    Video games can be played in many different contexts. This study examined associations between coplaying video games between siblings and levels of affection and conflict in the relationship. Participants were 508 adolescents (M age = 16.31 years of age, SD = 1.08) who completed questionnaires on video game use and sibling relationships. Participants were recruited from a large Northwestern city and a moderate city in the Mountain West of the United States. Video games played between siblings were coded by an independent sample to assess levels of physical aggression and prosocial behavior in each game. Playing video games with a sibling was associated with higher levels of sibling affection for both boys and girls, but higher levels of conflict for boys only. Playing a violent video game with a brother was associated with lower levels of conflict in the sibling relationship, whereas playing a prosocial video game was not related to any sibling outcome. The value of video games in sibling relationships will be discussed, with a focus on the type of game and the sex of the adolescent.

  1. Adolescent Siblings of Individuals With and Without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings About Their Brothers and Sisters.

    PubMed

    Shivers, Carolyn M; Dykens, Elisabeth M

    2017-01-01

    Siblings of brothers or sisters with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward their brothers or sisters with and without IDD, as well as broader aspects of sibling empathy. Data were collected via a national, online survey from 97 parent-sibling pairs. Siblings of individuals with IDD reported higher levels of anxiety toward the target child than did siblings of typically developing individuals. Sibling feelings toward the target child were related to both parental and target child factors, but only among families of individuals with IDD.

  2. Siblings' experiences of having a brother or sister with autism and mental retardation: a case study of 14 siblings from five families.

    PubMed

    Benderix, Ylva; Sivberg, Bengt

    2007-10-01

    The aim of this study was to describe the present and past experiences of 14 siblings from five families in terms of having a brother or sister with autism and mental retardation. Personal interviews were conducted with the siblings before their brothers or sisters were moved to a newly opened group home. Qualitative content analysis was used for the analysis of the transcribed texts. The analysis resulted in seven content categories: precocious responsibility, feeling sorry, exposed to frightening behavior, empathetic feelings, hoping that a group home will be a relief, physical violence made siblings feel unsafe and anxious, and relations with friends were affected negatively. The conclusion is that these siblings' experiences revealed stressful life conditions. Counseling for the family and for siblings is recommended to help them deal with their feelings and problems. For the siblings in these five families, a group home was a relevant alternative as a temporary or permanent placement for the child with autism and mental retardation.

  3. Sibling Supporters' Experiences of Giving Support to Siblings Who Have a Brother or a Sister With Cancer.

    PubMed

    Nolbris, Margaretha Jenholt; Nilsson, Stefan

    Siblings of a child with a life-threatening disease, such as cancer, have a right to measures that promote their health and welfare. Siblings may find it hard to understand what is happening to the sick child with cancer and why he or she reacts as he or she does. The aim of the study was to explore sibling supporters' thoughts about the experiences they had in providing support for siblings with a brother or a sister with a life-threatening disease such as cancer. All the 12 sibling supporters currently working in Sweden participated in a qualitative, descriptive study from which 5 categories emerged, showing that the sibling supporters supported siblings from diagnosis until possible death. They enabled siblings who were in the same situation to meet each other and arranged activities suited to their ages, as well as offering an encouraging environment. To help the siblings, the sibling supporters found it necessary to interact with both the parents and the ward staff. The sibling supporters felt that their support was important and necessary in helping siblings promote their own health both when the sick child was alive and also after his or her death. The experience of the sibling supporters was that they listened to the siblings' stories and met them when they were in their crisis. The study confirms that sibling supporters should be a part of the health care team that treat and support the family when a child has cancer.

  4. [Sense of coherence and ways of coping in the relationship with brother or sister in healthy siblings of mentally ill persons].

    PubMed

    Osuchowska-Kościjańska, Anna; Charzyńska, Katarzyna; Chadzyńska, Małgorzata; Drozdzyńska, Anna; Kasperek-Zimowska, Beata; Bednarek, Agata; Sawicka, Maryla

    2014-01-01

    The aim of the present study was to investigate sense of coherence in healthy siblings of persons suffering from schizophrenia as well as their ways of coping in the relationship with ill brother or sister. 40 healthy brothers and sisters of persons with ICD- 10 diagnosis of F20 to F29 participated in the present study. Orientation to Life Scale (SOC- 29) was used to assess sense of coherence and Ways of Coping with Stress questionnaire (SRSS) was used to examine stress coping strategies. Mean global score of siblings of persons with schizophrenia was 111 points. Subjects used coping strategies focused on problem significantly more often than those focused on emotions. Therapeutic work with healthy siblings should focus on strengthening sense of personal competence, development of personal resources and different ways of coping with stress, investigation of emotions that healthy siblings experience in the relationship with ill brother or sister as well as supporting the process of accepting changes in the relationship with the ill sibling.

  5. Big brother.

    PubMed

    Cross, M

    1993-04-15

    Both purchasers and providers will need to change the way they hold patient records on computer, or they could find themselves in breach of the law. Michael Cross examines a report by the Data Protection Registrar.

  6. Intrafamilial Sexual Abuse: Brother-Sister Incest Does Not Differ from Father-Daughter and Stepfather-Stepdaughter Incest.

    ERIC Educational Resources Information Center

    Cyr, Mireille; Wright, John; McDuff, Pierre; Perron, Alain

    2002-01-01

    A study compared 72 girls (ages 5-16) sexually abused by brothers, fathers, or stepfathers. Results suggested few differences in characteristics of sexual abuse. However, penetration was much more frequent in the sibling incest group. More victims of fathers and brothers manifested clinically significant distress (90%), than stepfather victims…

  7. The Influence of Big Brothers on the Separation-Individuation of Adolescents from Single-Parent Families.

    ERIC Educational Resources Information Center

    Saintonge, Serge; Achille, Pier Angelo; Lachance, Lise

    1998-01-01

    Investigates whether substitute father figures can aid male adolescents from single-parent families (N=29) with separation-individuation. Findings indicate that the adolescents with Big Brothers were less affected by parental rejection and appear to have healthier self-images, but they were more anxious when relating to male teachers. (Author/MKA)

  8. High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population.

    PubMed

    Linné, Anneli; Lindström, David; Hultgren, Rebecka

    2012-08-01

    Population-based screening for abdominal aortic aneurysms (AAAs) in elderly men is organized in many regions and countries in the Western world, and the prevalence of disease is reported to decline. Whether the prevalence among those with a family history also is declining is unknown. The primary purpose of this study was to assess the prevalence of AAAs among siblings of persons with AAAs and to investigate the proportion of siblings already diagnosed by opportunistic screening. Patients treated for AAAs from January 2008 through December 2010 (n = 412) in Stockholm, Sweden, were screened for siblings. Seven hundred seventy-nine siblings were identified. All siblings <80 years residing in Stockholm County were considered eligible and were invited to participate in the study (n = 174). Deceased siblings were not included in the study, regardless of the cause of death. One hundred fifty siblings were enrolled in the study after informed consent was provided. One hundred thirty-four siblings were screened for AAAs with ultrasound scan and maximum aortic, infrarenal, anteroposterior, external (outer-to-outer) aortic diameter was measured. Characteristics of siblings with and without AAAs were compared. The mean age of the screened siblings was 66.4 years (standard deviation, 7.1). Of the siblings, 11% were found to have an AAA, 17% (n = 11) of the brothers, and 6% (n = 5) of the sisters. Only 11% of the siblings were screened for AAAs before the study. One of 16 siblings with AAAs was <65 years. Ever smoking was evident in 81% of the AAA siblings compared to 59% in the non-AAA siblings. Factors associated with increased risk of AAAs in the multivariate regression analysis were: male sex (odds ratio, 3.4; 95% confidence interval, 1.1-10.8; P = .04) and age >65 (odds ratio, 10.8; 95% confidence interval, 1.3-86.4; P = .03). Ever smoking was not statistically significant as a risk. A strikingly high prevalence of AAAs in siblings was found as compared to the reported

  9. Extended Big-Brother experiments: the role of lateral boundary data quality and size of integration domain in regional climate modelling

    NASA Astrophysics Data System (ADS)

    Køltzow, Morten; Iversen, Trond; Haugen, Jan Erik

    2008-05-01

    Dynamical downscaling by atmospheric Regional Climate Models (RCMs) forced with low-resolution data should produce fine scale climate details with skill. This is investigated by adopting and extending the Big-Brother approach of Denis et al. (2002). A reference climate is established from a fine resolution RCM simulation in a large domain (the Big-Brother). These Big-Brother (BB) data are degraded by removing small scales, and then used for downscaling by the RCM (the Little Brother) with the same resolution as the BB in three domains of different size. Differences between the Little- and BB are attributed to errors caused by the downscaling. We have furthermore extended the original BB method and investigated the impact of the quality of the driving data. The RCM manage to reproduce the general large scale climate features of the BB when forced with high quality data, but show deficiencies when the driving data differ both in phase and scale from the BB. Forced with data with lower quality on a sufficiently large integration domain and in regions influenced by strong local forcing, the RCM significantly improve the climate statistics for local variables (2 m air-temperature, 10 m wind speed, precipitation). We even found that the improvement increased with domain size.

  10. "Big data" versus "big brother": on the appropriate use of large-scale data collections in pediatrics.

    PubMed

    Currie, Janet

    2013-04-01

    Discussions of "big data" in medicine often revolve around gene sequencing and biosamples. It is perhaps less recognized that administrative data in the form of vital records, hospital discharge abstracts, insurance claims, and other routinely collected data also offer the potential for using information from hundreds of thousands, if not millions, of people to answer important questions. However, the increasing ease with which such data may be used and reused has increased concerns about privacy and informed consent. Addressing these concerns without creating insurmountable barriers to the use of such data for research is essential if we are to avoid a "missed opportunity" in pediatrics research.

  11. Big Brother Experiments with the Regional Climate Model COSMO-CLM in an Idealised Setup to Investigate Lateral Boundary Conditions

    NASA Astrophysics Data System (ADS)

    Leps, Nora; Brauch, Jennifer; Ahrens, Bodo

    2017-04-01

    Our work aims at improving the regional coupled atmosphere-ocean model system COSMO-CLM/NEMO for decadal prediction. We address the different restricting conditions of regional climate modelling: Lower boundary conditions of the atmospheric system in the form of the coupled ocean, initial conditions and lateral boundary conditions of the coupled ocean-atmosphere system. Lateral boundary conditions (LBCs) are known to be an issue in dynamical downscaling with limited area regional climate models, and many studies have investigated the LBCs with regard to, e.g., frequency or resolution of LBCs, position of the domain and spurious effects. By default, the formulation of the LBCs in CCLM is a Davies relaxation scheme, which introduces a sponge layer at the lateral boundaries of the domain to dampen reflection of waves produced in the limited area domain at the prescribed boundaries. With idealised studies, it is possible to investigate the performance of this LBC formulation in CCLM in detail. The used framework is that of "big brother experiments" (BBEs). In a BBE, a high resolution simulation is performed over a larger domain, then its output is filtered to represent coarse-grid input, which is used to drive a nested smaller domain on the same high resolution. The differences between the two simulations can directly be attributed to the LBCs. Such experiments were performed in an idealised setup of a zonal flow over flat terrain or idealised hills with varying domain positions. First experiments show that for these idealised flows the relaxation works well for lateral boundary data on a high spatial resolution for different temporal resolutions. Next we plan to perform simulations with filtered lateral boundary data that only contains large scale features of the flow as well as different settings of the relaxation procedure.

  12. Big Brother Not Needed.

    ERIC Educational Resources Information Center

    Heinen, Edward

    1983-01-01

    Cites the recent United States State Department's labeling of recent Canadian films--one on nuclear war and two on acid rain--as political propaganda as a sign of the need to review the nature of propaganda. Suggests that teaching students to intelligently evaluate propaganda is preferable to submitting to government dictum. (MM)

  13. Big Brother Not Needed.

    ERIC Educational Resources Information Center

    Heinen, Edward

    1983-01-01

    Cites the recent United States State Department's labeling of recent Canadian films--one on nuclear war and two on acid rain--as political propaganda as a sign of the need to review the nature of propaganda. Suggests that teaching students to intelligently evaluate propaganda is preferable to submitting to government dictum. (MM)

  14. Comparison between high-resolution climate simulations using single- and double-nesting approaches within the Big-Brother experimental protocol

    NASA Astrophysics Data System (ADS)

    Matte, Dominic; Laprise, René; Thériault, Julie Mireille

    2016-12-01

    Regional climate models (RCM) are widely used to downscale global climate models' (GCMs) simulations. As the resolution of RCM increases faster than that of GCM used for climate-change projections till the end of this century, the resolution jump will become an issue. Cascade with multiple nesting offers an approach to reach high resolution while keeping reasonable computational cost. Few studies have addressed whether the best results are obtained with the single- or multiple-nesting approaches. In this study the results obtained with single and double nesting are compared within the idealised "perfect model" framework of the Big-Brother Experiment. This method consists in first realizing a simulation, nicknamed the Big-Brother (BB) simulation, on a relatively large domain at the desired resolution, to serve as reference dataset. The BB results are then processed by a low-pass filter to emulate a coarse-resolution dataset to be used as LBC to drive further simulations, nicknamed the Little-Brother (LB) simulations, using an identical model formulation and resolution as the BB simulation. For the single nesting, the LB simulations are directly simulated, while for the double nesting a surrogate intermediate-resolution simulation is used. The study of the time-mean (stationary) component shows that little difference is noted between the single- and double-nesting approaches. The time-deviation (transient-eddy) component, however, shows important differences. The double-nesting approach weakly degrades the large scales but allows a significant reduction of the required domain size to allow adequate spin-up of fine-scale features. This results in an important saving in the computational cost.

  15. Bah's Baby Brother Is Born.

    ERIC Educational Resources Information Center

    Tapahonso, Luci

    This illustrated story, written for Native American children, stresses the importance of not drinking alcohol and taking care of oneself during pregnancy. The story centers on Bah, a young Native American girl whose mother is going to have a baby. Bah is very excited about getting a baby brother or sister and wants the baby to be healthy and…

  16. My Brother

    NASA Astrophysics Data System (ADS)

    Kwartin, Ina

    I was lucky. I was born younger. My older brother has been with me my whole life. He was an altogether special person, very noble and generous, a foreigner to things kitsch and to banality. When I was a child, he spent a great deal of time with me. During that difficult period parents had to spend almost the whole day at work, and in many households children were l to themselves. At my home I had my brother, who was never a "babysitter" to me and never gave the impression that I was a burden to him. Being together was interesting…

  17. Considerations on domain location according to the jump of resolution between the driving data and the nested regional climate model within the Big-Brother experiment.

    NASA Astrophysics Data System (ADS)

    Matte, D.; Laprise, R.; Theriault, J. M.; Lucas-Picher, P.

    2015-12-01

    Many studies have shown the importance of choosing the domain size adequately for dynamical downscaling with nested regional climate models. It is well known that domain should not be too large to avoid large departure from the driving data, and not be too small to provide sufficient distance from the lateral inflow to allow a full development of the small-scale features resolved by the increase resolution. Although practitioners of dynamical downscaling are well aware that the jump of resolution between the driving data and the nested regional climate model impacts the simulated climate, the issue has never been properly study. Larger is the jump of resolution, larger is the distance from the lateral inflow to fully develop the small-scale features permitted by the increase resolution. Our investigation compares direct nesting to achieve a grid mesh of 0.15o from driving data at 3.6°, 1.8o, 0.45° and 0.15° using the perfect-prognostic approach of the Big-Brother protocol. The results show that the small-scale transient-eddy component struggles to be fully developed with reduced resolution of the driving data. Overall, this study suggests that domain location (i.e. domain of interest or subsequent nested domains) must be chosen carefully according to the jump of resolution to allow the optimal development of small-scale features allowed by the increase resolution of the nested model.

  18. Brothers and Sisters: Meeting Special Needs.

    ERIC Educational Resources Information Center

    Gallagher, Peggy A.; Powell, Thomas H.

    1989-01-01

    The literature is reviewed on sibling relationships involving a child who is handicapped. An analysis of interaction patterns for nonhandicapped children is also provided. Factors contributing to a sibling's adjustment include family size, socioeconomic status, and characteristics of the child who is handicapped. Potential instructional roles of…

  19. My Brother Warren.

    ERIC Educational Resources Information Center

    Forbes, Eric

    1987-01-01

    The younger brother of a hyperactive, severely learning-disabled 21-year-old recounts his feelings regarding lack of parental attention, jealousy toward his older brother, embarrassment, and finally empathy for his older brother. (CB)

  20. Smile on Your Brother: Teaching Siblings Together

    ERIC Educational Resources Information Center

    Carter, Paula

    2008-01-01

    A multiage first, second, and third grade classroom includes brothers, sisters, cousins. Two teachers use a developmentally appropriate approach while juggling teaching responsibilities and administering the many tests required by No Child Left Behind. Carter explains their four priorities for children: attendance, responsibility, honesty, and…

  1. Teletext--Prestel's Big Brother.

    ERIC Educational Resources Information Center

    Hughes, Geoffrey

    Prestel, Oracle, and Ceefax are telephone based video text systems currently in use in Great Britain. Rather than being considered as competitors, they should be viewed as complementary media with separate functions based on their differences. All use home television sets to receive information in print, and all broadcast on spare TV lines in the…

  2. Teletext--Prestel's Big Brother.

    ERIC Educational Resources Information Center

    Hughes, Geoffrey

    Prestel, Oracle, and Ceefax are telephone based video text systems currently in use in Great Britain. Rather than being considered as competitors, they should be viewed as complementary media with separate functions based on their differences. All use home television sets to receive information in print, and all broadcast on spare TV lines in the…

  3. 75 FR 71458 - Warner Brothers Entertainment, Inc., Warner Brothers Theatrical Enterprises, Including Workers of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ..., Inc., Warner Brothers Pictures, Warner Brothers Pictures International, Warner Brothers Studio... Pictures, Warner Brothers Pictures International, Warner Brothers Studio Facilities, and Warner Brothers...

  4. Sister-sister incest: data from an anonymous computerized survey.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims.

  5. Sisters and Brothers, Brothers and Sisters in the Family Affected by Traumatic Brain Injury.

    ERIC Educational Resources Information Center

    Pieper, Betty

    This report is based on a qualitative research study which utilized a nominal group process to identify major life stressors for parents of children with traumatic brain injuries (TBI). It focuses first on effects of TBI on siblings and then on effective interventions. The first section uses quotes from participating parents to identify their…

  6. Trisomy 1q42{r_arrow}qter in a sister and brother: Further delineation of the {open_quotes}trisomy 1q42{r_arrow}qter syndrome{close_quotes}

    SciTech Connect

    Verschuuren-Bemelmans, C.C.; Leegte, B.; Hodenius, T.M.J.

    1995-07-31

    We report on a 22-year-old woman and her 21-year-old brother with mild mental retardation, long face, prominent forehead, retrognathia, and (relative) macrocephaly. At birth they were small for date, their length is now below the 10th centile. Chromosome analysis demonstrated a nearly pure trisomy 1q42{r_arrow}qter in both patients due to unbalanced segregation of a paternal reciprocal balanced translocation 46,XY,t(1;15) (q42;p11). This is the second report of a nearly pure trisomy 1q42{r_arrow}qter. When comparing the manifestations of our patients with those of other reported cases we conclude that the most characteristic clinical manifestations of this syndrome are macrocephaly, prominent forehead, micro/retrognathia, large fontanelle, intrauterine growth retardation, postnatal growth retardation, and mental retardation. 56 refs., 4 figs., 1 tab.

  7. Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210A/A prothrombin mutation and heterozygous 1691G/A factor V Leiden mutation.

    PubMed

    Halbmayer, W M; Kalhs, T; Haushofer, A; Breier, F; Fischer, M

    1999-07-01

    We report on members of a Turkish thrombophilic family with coinheritance of the prothrombin mutation PT20210A and the factor V Leiden mutation. The 23-year-old propositus and his elder sister both had episodes of venous theomboembolism at a young age (23 years and 26 years, respectively) and are homozygous for the PT20210A mutation and heterozygous for the factor V Leiden mutation. The 51-year-old father is suffering from coronary heart disease and is heterozygous for both thrombophilic mutations. The asymptomatic 43-year-old mother is heterozygous for the PT20210A mutation, but without activated protein C resistance. Two other children, a 20-year-old girl who is homozygous for the PT20210A mutation and a 13-year-old boy who is heterozygous for the PT20210A mutation, are both free from activated protein C resistance and thrombosis. This report provides further evidence for an early onset of thromboembolic disorders in individuals with an homozygous state of the prothrombin variant 20210A/A and coinheritance of another thrombophilic mutation. Consensus guidelines are required for the treatment and prophylaxis of patients and subjects who remain asymptomatic with homozygous or more than one heterozygous genetic defect associated with thrombophilia.

  8. Siblings of Oedipus: Brothers and Sisters of Incest Victims.

    ERIC Educational Resources Information Center

    de Young, Mary

    1981-01-01

    Investigates the roles and problems of siblings of incest victims, describes the dynamics of the incestuous family, and identifies some behavior problems of children whose siblings were incest victims. Data from two siblings' lives are presented to illustrate points. (Author/DB)

  9. Babbitt's Brothers & Sisters: Raising Ethical Issues in Business Literature.

    ERIC Educational Resources Information Center

    Halpern, Jeanne W.

    A college-level course in business literature is an ideal place to raise and discuss ethical issues. To be successful, a teacher of this course must engage student interest, help the students articulate and understand their own ethical attitudes, clarify the stance and artistry of the author, and refine student responses to ethical questions. When…

  10. Ectrodactyly in sisters and half sisters.

    PubMed Central

    Mufti, M H; Wood, S K

    1987-01-01

    An extended family is described in which four sisters and half sisters presented with ectrodactyly. Two of the sisters had associated agenesis of the tibiae. The paper describes the malformations and discusses the management and possible genetic inheritance involved. An autosomal recessive gene seems likely to be the mode of inheritance. Images PMID:3585937

  11. Big Brother Is Not Watching You Act

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-15

    House - 03/20/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. Big Brother Is Not Watching You Act

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-15

    03/20/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  13. Big Brother Is Not Watching You Act

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-15

    03/20/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. Mentoring At-Risk Adolescent Girls: Listening to "Little Sisters"

    ERIC Educational Resources Information Center

    Maldonado, Nancy L.; Quarles, Alice; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    In order to develop an understanding of mentoring relationships and the impact these relationships might have on the development of high-risk adolescent girls, this qualitative study explored the relationships between six "Little Sisters" and their "Big Sister" mentors. The purposefully-selected sample includes women and girls…

  15. Brothers of the Christian Schools

    ERIC Educational Resources Information Center

    Salm, Luke

    2007-01-01

    The Brothers of the Christian Schools, popularly known in the United States as Christian Brothers, have made numerous significant contributions to the development of Catholic education. Building and staffing schools, colleges, and orphanages, producing textbooks and catechetical materials, advocating for the poor, and creating new models of…

  16. Where are Sedna's Sisters?

    NASA Astrophysics Data System (ADS)

    Bartlett, D. F.

    2005-05-01

    Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

  17. Goddard Welcomes SISTER

    NASA Image and Video Library

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  18. 77 FR 75503 - Wright Brothers Day, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... December 20, 2012 Part II The President Proclamation 8918--Wright Brothers Day, 2012 #0; #0; #0... Brothers Day, 2012 By the President of the United States of America A Proclamation After years of research... changed our way of life. On Wright Brothers Day, we reflect on their astonishing feat and celebrate...

  19. 75 FR 80669 - Wright Brothers Day, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Proclamation 8617--Wright Brothers Day, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register... President ] Proclamation 8617 of December 17, 2010 Wright Brothers Day, 2010 By the President of the United... conquered the age-old dream of manned flight. That day, the two brothers from Dayton, Ohio, could...

  20. 78 FR 76969 - Wright Brothers Day, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... December 19, 2013 Part III The President Proclamation 9071--Wright Brothers Day, 2013 #0; #0; #0... Brothers Day, 2013 By the President of the United States of America A Proclamation On December 17, 1903... boundaries of human imagination and paving the way for over a century of innovation. On Wright Brothers...

  1. THREE SISTERS WILDERNESS, OREGON.

    USGS Publications Warehouse

    MacLeod, Norman S.; Causey, J. Douglas

    1984-01-01

    A mineral survey of the Three Sisters Wilderness, Oregon indicated little promise for the occcurrence of metallic mineral resources. Block pumice suitable for commercial uses occurs at an undeveloped claim at Rock Mesa in the wilderness, but numerous other sources occur outside the wilderness closer to markets. A broad area centered around South Sister volcano is among the most favorable targets for geothermal resources in the Oregon Cascade Range, based on the very young age and large volume of silicic volcanic rocks that occur in this area. Deep exploration holes could be drilled in areas outside the wilderness south of South Sister to provide data on the subsurface thermal and hydrologic regimes in the southern part of the area most likely to contain geothermal resources.

  2. [Follicular lymphoma in two brothers].

    PubMed

    Asahi, A; Okamoto, S; Matsushita, H; Hattori, Y; Takayama, N; Ikeda, Y

    2001-05-01

    Two brothers, whose parents had a history of exposure to atomic bomb radiation, developed non-Hodgkin's lymphoma. The younger brother, a 48-year-old man, was diagnosed as having follicular small-cleaved cell lymphoma in October, 1996. He had extranodal lymphoma involvement of the right kidney, bone marrow and skin, in addition to generalized lymphadenopathy. He was treated with intermittent COP chemotherapy, and good control of the lymphoma was obtained. The elder brother, aged 50 years, was diagnosed as having follicular mixed cell lymphoma in May, 1998. He also had extranodal lymphoma involvement of the right parotid gland and bone marrow, as well as generalized lymphadenopathy. After one course of CHOP chemotherapy, he developed paresis of the lower legs and was found to have a mass at the Th5-6 vertebrae by CT scan. After four courses of CHOP chemotherapy followed by ESHAP chemotherapy and radiotherapy, he achieved complete remission, and has since been well. Follicular lymphoma occurring among siblings is rare. Further cytogenetic and molecular studies may provide a better understanding of its etiology.

  3. The Sister Libraries Programs.

    ERIC Educational Resources Information Center

    Sager, Don

    2000-01-01

    These articles describe the Sister Libraries program, part of the White House Millennium project, sponsored by the National Commission on Libraries and Information Science and the American Library Association to build relationships with libraries in other cultures. Discusses projects with public and school libraries and library development in…

  4. Scott Brothers Windows and Doors Information Sheet

    EPA Pesticide Factsheets

    Scott Brothers Windows and Doors (the Company) is located in Bridgeville, Pennsylvania. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Pittsburgh, Pennsylvania.

  5. Quantitative and theoretical analyses of the relation between older brothers and homosexuality in men.

    PubMed

    Blanchard, Ray

    2004-09-21

    Meta-analysis of aggregate data from 14 samples representing 10,143 male subjects shows that homosexuality in human males is predicted by higher numbers of older brothers, but not by higher numbers of older sisters, younger brothers, or younger sisters. The relation between number of older brothers and sexual orientation holds only for males. This phenomenon has therefore been called the fraternal birth order effect. Research on birth order, birth weight, and sexual orientation suggests that the developmental pathway to homosexuality initiated by older brothers operates during prenatal life. Calculations assuming a causal relation between older brothers and sexual orientation have estimated the proportion of homosexual men who owe their sexual orientation to fraternal birth order at 15% in one study and 29% in another. The maternal immune hypothesis proposes that the fraternal birth order effect reflects the progressive immunization of some mothers to male-specific antigens by each succeeding male fetus and the increasing effects of such immunization on sexual differentiation of the brain in each succeeding male fetus. There are at least three possible mechanisms by which the mother's immune response could influence the fetus: the transfer of anti-male antibodies across the placenta from the maternal into the fetal compartment, the transfer of maternal cytokines across the placenta, and maternal immune reactions affecting the placenta itself. This hypothesis is consistent with recent studies showing that the quantity of fetal cells that enter the maternal circulation is greater than previously thought, and that the number of male-specific proteins encoded by Y-chromosome genes is greater than previously thought.

  6. Nature vs. nurture: two brothers with schizophrenia.

    PubMed

    Keltner, N L; James, C A; Darling, R J; Findley, L S; Oliver, K

    2001-01-01

    The nature vs. nurture argument as it pertains to two brothers. To explore the synergistic effects of heritability and environment in the cases of two brothers with schizophrenia. Review of the literature and the authors' clinical experience. The nature vs. nurture dichotomy may not be as relevant as looking at the interaction between these two forces.

  7. 76 FR 79019 - Wright Brothers Day, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... December 20, 2011 Part III The President Proclamation 8767--Wright Brothers Day, 2011 Memorandum of... ] Proclamation 8767 of December 15, 2011 Wright Brothers Day, 2011 By the President of the United States of... this day, guide our jetliners to every corner of the world and our spacecraft to the farthest...

  8. "My Brother Likes Meeting New People, but Don't Ask Him Any Direct Questions": Involving Adults with Autism plus Learning Disability in a Qualitative Research Project

    ERIC Educational Resources Information Center

    Tozer, Rosemary; Atkin, Karl; Wenham, Aniela

    2014-01-01

    Adult siblings of people with autism and a learning disability have hitherto been largely overlooked by research, policy and practice in the UK. As part of a qualitative study focussing on adult siblings, we met twelve people with autism plus severe learning disability with their brother or sister. Individually tailored resources were used to make…

  9. Pituitary cretinism in two sisters.

    PubMed Central

    Kohno, H; Watanabe, N; Ootsuka, M; Kajiwara, M; Gohya, N

    1980-01-01

    Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after administration of thyrotropin-releasing hormone. We conclude that cretinism in these 2 sisters was due to TSH deficiency. This is the second report of 'familial' pituitary cretinism (TSH-deficient congenital hypothyroidism). PMID:7436542

  10. Examining Big Brother's Purpose for Using Electronic Performance Monitoring

    ERIC Educational Resources Information Center

    Bartels, Lynn K.; Nordstrom, Cynthia R.

    2012-01-01

    We examined whether the reason offered for electronic performance monitoring (EPM) influenced participants' performance, stress, motivation, and satisfaction. Participants performed a data-entry task in one of five experimental conditions. In one condition, participants were not electronically monitored. In the remaining conditions, participants…

  11. Examining Big Brother's Purpose for Using Electronic Performance Monitoring

    ERIC Educational Resources Information Center

    Bartels, Lynn K.; Nordstrom, Cynthia R.

    2012-01-01

    We examined whether the reason offered for electronic performance monitoring (EPM) influenced participants' performance, stress, motivation, and satisfaction. Participants performed a data-entry task in one of five experimental conditions. In one condition, participants were not electronically monitored. In the remaining conditions, participants…

  12. Big Brother Is Watching: Video Surveillance on Buses

    ERIC Educational Resources Information Center

    Sloggett, Joel

    2009-01-01

    Many school districts in North America have adopted policies to permit cameras on their properties and, when needed, on buses used to transport students. With regard to school buses, the camera is typically a tool for gathering information to monitor behavior or to help investigate a complaint about behavior. If a picture is worth a thousand…

  13. Chromosome segregation: Samurai separation of Siamese sisters.

    PubMed

    Glotzer, M

    1999-07-15

    How do cells ensure that sister chromatids are precisely partitioned in mitosis? New studies on budding yeast have revealed that sister chromatid separation at anaphase requires endoproteolytic cleavage of a protein that maintains the association between sister chromatids.

  14. Small supernumerary marker chromosomes and the nuclear architecture of sperm - a study in a fertile and an infertile brother.

    PubMed

    Karamysheva, Tatyana; Kosyakova, Nadezda; Guediche, Narjes; Liehr, Thomas

    2015-01-01

    Small supernumerary marker chromosomes (sSMC) are found about four times more frequently in subfertile compared to the general population. The reason for this finding is still unclear. However, a connection of interphase architecture and genome function is suggested. And as we found in a previous study the presence of sSMC influences the nuclear architecture of peripheral blood cells and fibroblasts, we hypothesized that sSMC could have similar effects in sperm cells possibly leading to infertility. Here we applied for the first time 3-dimensional interphase fluorescence in situ hybridization (3D-FISH) to characterize the position of an extra-chromosome with respect to its sister- and selected other chromosomes (6, 15, 18, 19, 21, X, and Y) in sperm. Two sSMC carrier brothers with the identical sSMC derived from chromosome 15 were studied. One of the brothers was fertile and the other brother was infertile. Deviations from the normal positioning of chromosomes 21 and Y were seen in both brothers and for chromosomes 19 and X only in the infertile brother. Most striking were high rates of nullisomy and/or disomy for chromosomes 15, including sSMC (15), and 18 exclusively seen in the infertile brother. Overall, further evidence is provided that sSMC influence the nuclear architecture of a cell, including sperm. Further studies are necessary in sperm of fertile and infertile sSMC carriers to elaborate if the detected aneuploidy like that seen in the infertile brother is due to sSMC presence and disturbance of nuclear architecture.

  15. Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome.

    PubMed

    Liu, D M; Torchen, L C; Sung, Y; Paparodis, R; Legro, R S; Grebe, S K; Singh, R J; Taylor, R L; Dunaif, A

    2014-12-01

    = 0.005) responses were increased in brothers compared with controls. The modest sample size may have limited our ability to observe other possible differences in steroidogenesis between PCOS brothers and control men. Decreased ACTH-stimulated Δ17Preg/Δ17Prog and ΔDHEA/ΔAD responses suggested increased adrenal 3β-hydroxysteroid dehydrogenase activity in the brothers. Decreased Δ17Prog/ΔAD and increased ΔAD/ΔT responses to GnRH agonist stimulation suggested increased gonadal 17,20-lyase and decreased gonadal 17β-hydroxysteroid dehydrogenase activity in the brothers. Increased LH and FSH responses to GnRH agonist stimulation suggested neuroendocrine alterations in the regulation of gonadotrophin secretion similar to those in their proband sisters. These changes in PCOS brothers may reflect the impact of PCOS susceptibility genes and/or programming effects of the intrauterine environment. This research was supported by P50 HD044405 (A.D.), K12 HD055884 (L.C.T.), U54 HD034449 (A.D., R.S.L.) from the National Institute of Child Health and Development. Some hormone assays were performed at the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core that is supported by U54 HD28934 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Partial support for some of the clinical studies was provided by UL1 RR025741 and UL1 TR000150 (Northwestern University Clinical and Translational Sciences Institute) from the National Center for Research Resources, National Institutes of Health, which is now the National Center for Advancing Translational Sciences. The authors have no conflict of interest to declare. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome

    PubMed Central

    Liu, D.M.; Torchen, L.C.; Sung, Y.; Paparodis, R.; Legro, R.S.; Grebe, S.K.; Singh, R.J.; Taylor, R.L.; Dunaif, A.

    2014-01-01

    .1 controls, IU/l P = 0.002), AD (1.7 ± 1.4 brothers versus 0.9 ± 1.5 controls, nmol/l, P = 0.02) and ΔAD/ΔT (0.16 ± 0.14 brothers versus 0.08 ± 0.12 controls, P = 0.005) responses were increased in brothers compared with controls. LIMITATIONS, REASONS FOR CAUTION The modest sample size may have limited our ability to observe other possible differences in steroidogenesis between PCOS brothers and control men. WIDER IMPLICATIONS OF THE FINDINGS Decreased ACTH-stimulated Δ17Preg/Δ17Prog and ΔDHEA/ΔAD responses suggested increased adrenal 3β-hydroxysteroid dehydrogenase activity in the brothers. Decreased Δ17Prog/ΔAD and increased ΔAD/ΔT responses to GnRH agonist stimulation suggested increased gonadal 17,20-lyase and decreased gonadal 17β-hydroxysteroid dehydrogenase activity in the brothers. Increased LH and FSH responses to GnRH agonist stimulation suggested neuroendocrine alterations in the regulation of gonadotrophin secretion similar to those in their proband sisters. These changes in PCOS brothers may reflect the impact of PCOS susceptibility genes and/or programming effects of the intrauterine environment. STUDY FUNDING/COMPETING INTEREST(S) This research was supported by P50 HD044405 (A.D.), K12 HD055884 (L.C.T.), U54 HD034449 (A.D., R.S.L.) from the National Institute of Child Health and Development. Some hormone assays were performed at the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core that is supported by U54 HD28934 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Partial support for some of the clinical studies was provided by UL1 RR025741 and UL1 TR000150 (Northwestern University Clinical and Translational Sciences Institute) from the National Center for Research Resources, National Institutes of Health, which is now the National Center for Advancing Translational Sciences. The authors have no conflict of interest to declare. PMID:25336708

  17. Everyday Learning about Brothers & Sisters. Everyday Learning Series. Volume 3, Number 2

    ERIC Educational Resources Information Center

    Mackey, Gerrie

    2005-01-01

    The "Everyday Learning" series has been developed to focus attention on the everyday ways in which children can be supported in their growth and development. It is for all those who are involved in children's development and learning, including early childhood professionals in all children's services, parents, grandparents and others…

  18. Why "Brother and Sister" Are Not Just "Siblings": Repair Processes in Agreement Computation

    ERIC Educational Resources Information Center

    Molinaro, Nicola; Vespignani, Francesco; Zamparelli, Roberto; Job, Remo

    2011-01-01

    In the present study we analyze how the cognitive system deals on-line with number agreement mismatches and whether this on-line process influences the off-line interpretation of the sentence. In two ERP experiments we monitored the on-line processing consequences of subject-verb agreement mismatches, focusing on the integration of a following…

  19. "You Can Do Nasty Things to Your Brothers and Sisters without a Reason": Siblings' Backstage Behaviour

    ERIC Educational Resources Information Center

    Punch, Samantha

    2008-01-01

    This article contributes to the recent, but still limited, literature on the sociology of sibship. It argues that during childhood the ambivalent love/hate nature of sibship is played out through the sharing of knowledge, time and space. It draws on the work of Goffman to illustrate that children's sibling interactions tend to consist of…

  20. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... on the miner at the pertinent time; (3) Proof of support is filed within 2 years after the miner's... 223(d) of the Social Security Act, 42 U.S.C. 423(d), which began before such individual attained age... (see § 725.209(b)); or (iv) Is under a disability as defined in section 223(d) of the Social Security...

  1. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... on the miner at the pertinent time; (3) Proof of support is filed within 2 years after the miner's... 223(d) of the Social Security Act, 42 U.S.C. 423(d), which began before such individual attained age... (see § 725.209(b)); or (iv) Is under a disability as defined in section 223(d) of the Social Security...

  2. Brothers, Sisters and Fictive Kin: Communication about Sex among Urban Black Siblings

    ERIC Educational Resources Information Center

    Wallace, Scyatta A.; Hooper, Lisa M.; Persad, Malini

    2014-01-01

    Siblings have been shown to influence youth substance use and violent behavior. However, limited research has examined sibling-influences on sexual activity, particularly among urban Black youth. The current qualitative research was an exploratory study to describe discussions among siblings about sex and sexual health. Individual interviews were…

  3. Mothers' Differential Treatment of Adolescent Siblings: Predicting College Attendance of Sisters versus Brothers

    ERIC Educational Resources Information Center

    Bissell-Havran, Joanna M.; Loken, Eric; McHale, Susan M.

    2012-01-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We…

  4. Who Are My Sisters and Brothers? Reflections on Understanding and Welcoming Immigrants and Refugees.

    ERIC Educational Resources Information Center

    United States Catholic Conference, Washington, DC.

    The essays in this collection are presented as reflections to accompany an educational guide on the response of the Catholic Christian to immigrants and refugees. The following essays are included: (1) "Refugees Today: Rescue or Containment?" (Richard Ryscavage); (2) "Catholic Church Teachings and Documents Regarding Immigration: Theological…

  5. What Do Brothers and Sisters Think? An Investigation of Expectations of Siblings with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Ivey, Julie K.; Barnard-Brak, Lucy

    2009-01-01

    This study, with its foundation in expectancy theory, investigated the expectations of siblings of children with autism spectrum disorders (ASD). Forty siblings, 7-22 years of age, in Texas completed a 19-item survey that examined the expectations of siblings of persons with ASD according to the sex and age characteristics of these sibling dyads.…

  6. Effects of Older Brother-Younger Sister Incest: A Study of the Dynamics of 17 Cases.

    ERIC Educational Resources Information Center

    Laviola, Marisa

    1992-01-01

    This study of 17 cases of incest between siblings found the women commonly experienced mistrust of men and women, chronic low or negative self-esteem, sexual response difficulties, and intrusive thoughts of the incest. Individual therapy, talking with supportive family and friends, and validating themselves as victims were seen as helpful.…

  7. "You Can Do Nasty Things to Your Brothers and Sisters without a Reason": Siblings' Backstage Behaviour

    ERIC Educational Resources Information Center

    Punch, Samantha

    2008-01-01

    This article contributes to the recent, but still limited, literature on the sociology of sibship. It argues that during childhood the ambivalent love/hate nature of sibship is played out through the sharing of knowledge, time and space. It draws on the work of Goffman to illustrate that children's sibling interactions tend to consist of…

  8. Born to be poor: birthplace and number of brothers and sisters as factors in adult poverty.

    PubMed

    Orshansky, M; Bretz, J S

    1976-01-01

    Household heads who grew up as members of large families and/or as natives of small towns or rural areas tend to have less education and are more likely to be poor than those coming from small families and/or large cities. Data to support these conclusions have been drawn from two independent sources--a special Social Security Administration supplement to the April 1968 Current Population Survey and findings from the Retirement History Study conducted by the Social Security Administration.

  9. Mothers' Differential Treatment of Adolescent Siblings: Predicting College Attendance of Sisters versus Brothers

    ERIC Educational Resources Information Center

    Bissell-Havran, Joanna M.; Loken, Eric; McHale, Susan M.

    2012-01-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We…

  10. When Your Brother or Sister Has Cancer: A Guide for Teens

    MedlinePlus

    ... go for a run, read, or listen to music. ➜ Make a snack. Make a snack for the ... night. ■ Pray or meditate. ■ Make or listen to music. ■ Add your own here: __________________________________________ 57 ➜ Help others. ■ Join ...

  11. What We Learn from Our Sisters and Brothers: For Better or for Worse

    ERIC Educational Resources Information Center

    Kramer, Laurie; Conger, Katherine J.

    2009-01-01

    Siblings have considerable influence on one another's development throughout childhood, yet most human development research has neglected sibling socialization. Through this volume, we aim to enhance our understanding of how siblings play formative roles in one another's social and emotional development. We examine the mechanisms by which children…

  12. Brothers, Sisters and Fictive Kin: Communication about Sex among Urban Black Siblings

    ERIC Educational Resources Information Center

    Wallace, Scyatta A.; Hooper, Lisa M.; Persad, Malini

    2014-01-01

    Siblings have been shown to influence youth substance use and violent behavior. However, limited research has examined sibling-influences on sexual activity, particularly among urban Black youth. The current qualitative research was an exploratory study to describe discussions among siblings about sex and sexual health. Individual interviews were…

  13. Preschool Siblings of Handicapped Children: Interactions with Mothers, Brothers, and Sisters.

    ERIC Educational Resources Information Center

    Lobato, Debra J.; And Others

    1991-01-01

    This study, involving 40 young siblings of either handicapped or nonhandicapped children, found that siblings of handicapped children engaged in more parallel and social play and were more nurturing with their siblings than were control children. Mothers were more likely to deliver commands, directives, and reprimands to siblings of handicapped…

  14. Sibling Relationships and Adjustment of Children with Disabled Brothers and Sisters.

    ERIC Educational Resources Information Center

    McHale, Susan M.; Gamble, Wendy C.

    1987-01-01

    Examination of children with disabled siblings reveals that nondisabled children may treat their siblings more kindly and spend more time caring for them than do children with nondisabled siblings. Their experiences may produce more worries and anxieties; however, they also may develop more tolerance and humanitarian concerns. (Author/BJV)

  15. Who Are My Sisters and Brothers? Reflections on Understanding and Welcoming Immigrants and Refugees.

    ERIC Educational Resources Information Center

    United States Catholic Conference, Washington, DC.

    The essays in this collection are presented as reflections to accompany an educational guide on the response of the Catholic Christian to immigrants and refugees. The following essays are included: (1) "Refugees Today: Rescue or Containment?" (Richard Ryscavage); (2) "Catholic Church Teachings and Documents Regarding Immigration: Theological…

  16. The Brothers and Sisters Learn To Write: Popular Literacies in Childhood and School Cultures.

    ERIC Educational Resources Information Center

    Dyson, Anne Haas

    Building on the author's groundbreaking work in "Building Superheroes," this book traces the influence of a wide-ranging set of "textual toys" from children's lives--church and hip-hop songs, rap music, movies, TV, traditional jump-rope rhymes, the words of professional sports announcers and radio deejays--upon school learning…

  17. Preschool Siblings of Handicapped Children: Interactions with Mothers, Brothers, and Sisters.

    ERIC Educational Resources Information Center

    Lobato, Debra J.; And Others

    1991-01-01

    This study, involving 40 young siblings of either handicapped or nonhandicapped children, found that siblings of handicapped children engaged in more parallel and social play and were more nurturing with their siblings than were control children. Mothers were more likely to deliver commands, directives, and reprimands to siblings of handicapped…

  18. Family-focused prevention with Latinos: What about sisters and brothers?

    PubMed

    Updegraff, Kimberly A; Umaña-Taylor, Adriana J; Rodríguez De Jesús, Sue A; McHale, Susan M; Feinberg, Mark F; Kuo, Sally I-Chun

    2016-08-01

    Using a randomized, intent-to-treat design, this pilot study examined the feasibility and short-term effects of Siblings Are Special (SIBS) with a sample of 54 low-income Latino families (91% Mexican-origin). Participants were older (M = 10.8 years; SD = .46) and younger siblings (M = 8.4 years; SD = 1.13), and their parents (94% biological mothers), who were randomly assigned within school to the intervention (n = 28) or no-attention control (n = 26) condition. The intervention condition included 12 weekly afterschool sessions (90 min each) for sibling pairs and 3 family nights for parents and siblings (2 hr each). SIBS was designed to enhance sibling relationships via 2 primary intervention targets: (a) children’s capacities that underlie positive sibling dynamics, including relationship skills, cognitions, and shared activities; and (b) parenting of siblings, specifically, enhancing positive guidance and involvement and discouraging authoritarian control. Pre- and posttest data were gathered from siblings and parents. Recruitment and implementation data revealed high rates of attendance and completion, and high ratings of parent satisfaction with the program. Further, analyses suggested the program had positive effects of small to modest magnitude on posttest measures of sibling and parent–child relationship quality, parenting of siblings, older siblings’ emotional efficacy, and parents’ depressive symptoms and parenting stress, controlling for pretest levels of all outcomes and family background characteristics. Discussion addresses the feasibility of sibling-focused programs with low-income Latino families and makes recommendations for future research.

  19. The Role of Gender in Youth Mentoring Relationship Formation and Duration

    ERIC Educational Resources Information Center

    Rhodes, Jean; Lowe, Sarah R.; Litchfield, Leon; Walsh-Samp, Kathy

    2008-01-01

    The role of gender in shaping the course and quality of adult-youth mentoring relationships was examined. The study drew on data from a large, random assignment evaluation of Big Brothers Big Sisters of America (BBSA) programs [Grossman, J. B., & Tierney, J. P. (1998). Does mentoring work? An impact study of the Big Brothers Big Sisters program.…

  20. The Role of Gender in Youth Mentoring Relationship Formation and Duration

    ERIC Educational Resources Information Center

    Rhodes, Jean; Lowe, Sarah R.; Litchfield, Leon; Walsh-Samp, Kathy

    2008-01-01

    The role of gender in shaping the course and quality of adult-youth mentoring relationships was examined. The study drew on data from a large, random assignment evaluation of Big Brothers Big Sisters of America (BBSA) programs [Grossman, J. B., & Tierney, J. P. (1998). Does mentoring work? An impact study of the Big Brothers Big Sisters program.…

  1. Pleural mesothelioma in a couple of brothers

    PubMed Central

    Bianchi, Claudio; Bianchi, Tommaso

    2013-01-01

    Malignant mesotheliomas of the pleura, epithelial type, were observed in two brothers. Both the patients had histories of severe exposure to asbestos, having worked as insulators. The latency periods in the two cases were 26 and 38 years, respectively. Available literature data suggest that mesothelioma occurrence among blood-related people is favored by a genetic predisposition. PMID:24872671

  2. My Brother's Keeper

    ERIC Educational Resources Information Center

    Obama, Barack

    2014-01-01

    In a White House address, the president announced an initiative to reclaim young boys and men of color. The "My Brother's Keeper" initiative partners with businesses, foundations, and nonprofits to address disparities in education, justice, and employment. President Obama was introduced by Christian, one of a group of students from…

  3. Build Your Own Wright Brothers' Glider

    ERIC Educational Resources Information Center

    Schimmel, Gordon; Hand, Jon; Ellis, Art

    2003-01-01

    A little more than one hundred years ago, Wilbur and Orville Wright began building models of airfoils and testing them in wind tunnels in their search for an efficient wing. Models continue to be used today by aerospace engineers to prove concepts and launch dreams. To celebrate the centennial of the Wright brothers' historic flight, the authors…

  4. My Brother's Keeper

    ERIC Educational Resources Information Center

    Obama, Barack

    2014-01-01

    In a White House address, the president announced an initiative to reclaim young boys and men of color. The "My Brother's Keeper" initiative partners with businesses, foundations, and nonprofits to address disparities in education, justice, and employment. President Obama was introduced by Christian, one of a group of students from…

  5. Writing siblings: Alice James and her brothers.

    PubMed

    Hoffman, Anne Golomb

    2015-02-01

    This essay addresses the relationship of writing to embodiment, through representations of bodily sensation and fantasy in the journal of Alice James. It considers Alice James's writing in relation to her two writer brothers, William and Henry, and in light of their father's experiences of impairment and breakdown.

  6. Build Your Own Wright Brothers' Glider

    ERIC Educational Resources Information Center

    Schimmel, Gordon; Hand, Jon; Ellis, Art

    2003-01-01

    A little more than one hundred years ago, Wilbur and Orville Wright began building models of airfoils and testing them in wind tunnels in their search for an efficient wing. Models continue to be used today by aerospace engineers to prove concepts and launch dreams. To celebrate the centennial of the Wright brothers' historic flight, the authors…

  7. Big Data: Big Confusion? Big Challenges?

    DTIC Science & Technology

    2015-05-01

    12th Annual Acquisition Research Symposium 12th Annual Acquisition Research Symposium Big Data : Big Confusion? Big Challenges? Mary Maureen... Data : Big Confusion? Big Challenges? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...Acquisition Research Symposium • ~!& UNC CHARlD1TE 90% of the data in the world today was created in the last two years Big Data growth from

  8. Two brothers with keratosis follicularis spinulosa decalvans.

    PubMed

    Alfadley, Abdullah; Al Hawsawi, Khalid; Hainau, Bo; Al Aboud, Khalid

    2002-11-01

    Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder affecting both the skin and eyes. There are few reports about this entity. The aim of this report is to describe 2 brothers with progressive scarring alopecia of the scalp, hypotrichosis with follicular prominence of the eyelashes, and extensive keratosis pilaris. The second patient has Down syndrome with palmoplantar keratoderma and partial alopecia of the eyebrows. We also reviewed the literature about this uncommon entity.

  9. Brotherly Love? The Manipulation of Body Boundaries

    ERIC Educational Resources Information Center

    Beck, Benjamin

    2011-01-01

    This article is about a street-wise boy who is unaware that his younger brother has been using clever manipulation to get him into trouble. Nicholas is a 12-year-old boy whose father was recently given a life sentence for murder. Nicholas is in a boxing league and uses his fighting skills on the streets. Angel is Nicholas' nine-year-old brother…

  10. Brotherly Love? The Manipulation of Body Boundaries

    ERIC Educational Resources Information Center

    Beck, Benjamin

    2011-01-01

    This article is about a street-wise boy who is unaware that his younger brother has been using clever manipulation to get him into trouble. Nicholas is a 12-year-old boy whose father was recently given a life sentence for murder. Nicholas is in a boxing league and uses his fighting skills on the streets. Angel is Nicholas' nine-year-old brother…

  11. A Brief Analysis of Sister Carrie's Character

    ERIC Educational Resources Information Center

    Yu, Hanying

    2010-01-01

    Carrie is always dreaming while the rocking chair is rocking again and again, this is the deep impression on us after we read "Sister Carrie" which is the first novel of Theodore Dreiser. In this novel the protagonist Sister Carrie is a controversial person. This paper tries to analyze the character of Sister Carrie in order to find out…

  12. Two Sisters with Rett Syndrome. Brief Report.

    ERIC Educational Resources Information Center

    Haenggeli, Charles A.; And Others

    1990-01-01

    Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

  13. Two Sisters with Rett Syndrome. Brief Report.

    ERIC Educational Resources Information Center

    Haenggeli, Charles A.; And Others

    1990-01-01

    Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

  14. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor"…

  15. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor"…

  16. The Mayo brothers: an American surgical legacy.

    PubMed

    Toledo-Pereyra, Luis H

    2010-10-01

    Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams.

  17. Traits of ADHD and autism in girls with a twin brother: a Mendelian randomization study.

    PubMed

    Attermann, Jørn; Obel, Carsten; Bilenberg, Niels; Nordenbæk, Claudia Maria; Skytthe, Axel; Olsen, Jørn

    2012-09-01

    It has been hypothesized that prenatal exposure to testosterone may be associated with traits of attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD). We conducted a population-based study of dizygotic female twins to elucidate this hypothesis, assuming that the sex of the co-twin influences the level of prenatal exposure to testosterone. We invited parents of 24,552 3- to 15-year-old twins to answer questionnaires on traits of ADHD and ASD. We analysed the data using a proportional odds model with sex of the co-twin as an instrumental variable for prenatal exposure to testosterone of female twins. We received responses for 6,339 girls from dizygotic twin pairs. Odds ratios for male versus female co-twin were 0.71 (95 % confidence interval 0.61-0.81) for ADHD traits and 0.74 (0.66-0.83) for ASD traits, indicating that a twin brother reduces traits of ADHD and ASD in females. In conclusion, we found that female twins with a twin brother scored significantly lower in parent-reported traits of ADHD and ASD than those with a twin sister. The reason for this may be parental reporting bias, or confounding by unmeasured variables, or a causal effect of an intrauterine environment modified by the sex of the co-twin in the opposite direction of what we expected.

  18. Big Society, Big Deal?

    ERIC Educational Resources Information Center

    Thomson, Alastair

    2011-01-01

    Political leaders like to put forward guiding ideas or themes which pull their individual decisions into a broader narrative. For John Major it was Back to Basics, for Tony Blair it was the Third Way and for David Cameron it is the Big Society. While Mr. Blair relied on Lord Giddens to add intellectual weight to his idea, Mr. Cameron's legacy idea…

  19. Big Society, Big Deal?

    ERIC Educational Resources Information Center

    Thomson, Alastair

    2011-01-01

    Political leaders like to put forward guiding ideas or themes which pull their individual decisions into a broader narrative. For John Major it was Back to Basics, for Tony Blair it was the Third Way and for David Cameron it is the Big Society. While Mr. Blair relied on Lord Giddens to add intellectual weight to his idea, Mr. Cameron's legacy idea…

  20. Bram Stoker's brother, the brain surgeon.

    PubMed

    Stiles, Anne

    2013-01-01

    This essay examines the life and work of Sir William Thornley Stoker, 1st Baronet (1845-1912), the eldest brother of Bram Stoker (1847-1912), the author of Dracula (1897). Sir William or "Thornley," as he was commonly known, was one of Ireland's leading physicians. He performed some of the first brain surgeries in Ireland using Sir David Ferrier's maps of the cerebral cortex. From 1879 into the twentieth century, Thornley served as inspector for Ireland under the 1876 Cruelty to Animals Act. In this role, Thornley was responsible for granting licenses to researchers who performed experiments on live animals. Due to his reservations about animal experimentation, Thornley eventually became an advocate for the antivivisection cause, testifying at the second Royal Commission on Vivisection (1906-1912). Thornley also influenced Irish literature, albeit indirectly. Bram Stoker's composition notes for Dracula show that he consulted his older brother about the medical scenes in his novel. Thornley's knowledge of cerebral localization and his animal rights advocacy both surface in Dracula. © 2013 Elsevier Inc. All rights reserved.

  1. 36 CFR 7.76 - Wright Brothers National Memorial.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Memorial. 7.76 Section 7.76 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.76 Wright Brothers National Memorial. (a) Designated airstrip. Wright Brothers National Memorial Airstrip, located at Kill Devil Hills,...

  2. 36 CFR 7.76 - Wright Brothers National Memorial.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Memorial. 7.76 Section 7.76 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.76 Wright Brothers National Memorial. (a) Designated airstrip. Wright Brothers National Memorial Airstrip, located at Kill Devil Hills,...

  3. Two Dutch brothers with Borrone dermato-cardio-skeletal syndrome.

    PubMed

    van Steensel, M A M; Ceulen, R P M; Delhaas, T; de Die-Smulders, C

    2007-06-01

    In 1993, Borrone et al. described two Italian brothers affected by a syndrome of severe acne, mitral valve prolapse, dysmorphic facies, and Scheuermann-like changes of the vertebral column. Since then, no further cases have been reported. Here, we report on two Dutch brothers with many features suggestive of this rare syndrome.

  4. Authentic Expression of Edmund Rice Christian Brother Education

    ERIC Educational Resources Information Center

    Vercruysse, Raymond J.

    2007-01-01

    In 1802, Edmund Rice directed the laying of the foundation stone for Mount Sion Monastery and School. After several previous attempts of instructing poor boys in Waterford, this was to be the first permanent home for the Congregation of Christian Brothers. Rice's dream of founding a religious community of brothers was becoming a reality with a…

  5. Holocentric plant meiosis: first sisters, then homologues.

    PubMed

    Heckmann, Stefan; Schubert, Veit; Houben, Andreas

    2014-01-01

    Meiosis is a crucial process of sexual reproduction by forming haploid gametes from diploid precursor cells. It involves 2 subsequent divisions (meiosis I and meiosis II) after one initial round of DNA replication. Homologous monocentric chromosomes are separated during the first and sister chromatids during the second meiotic division. The faithful segregation of monocentric chromosomes is realized by mono-orientation of fused sister kinetochores at metaphase I and by bi-orientation of sister kinetochores at metaphase II. Conventionally this depends on a 2-step loss of cohesion, along chromosome arms during meiosis I and at sister centromeres during meiosis II.

  6. Neurological and architectural sinuosities: the Niemeyer brothers.

    PubMed

    Cavalcanti, Daniel D; Guasti, José Antonio D; Preul, Mark C

    2010-11-01

    In a family of 7 siblings in Rio de Janeiro, Brazil, 2 of the most remarkable national personalities decided to follow different fields at the beginning of the 20th century. Their life's work would, however, intersect in at least 2 respects: the quest for innovation and a passion for sinuosity. The achievements of Paulo and Oscar Niemeyer are landmarks in the history of neurosurgery and architecture in Brazil. Among his many innovations in neurosurgery, Paulo Niemeyer first described the transventricular amygdalohippocampectomy in 1957 and introduced the operating microscope to neurosurgery in Brazil in 1971. His brother Oscar became a world-renowned representative of the modern architecture movement, sculpting graceful curves from concrete.

  7. Precalcaneal congenital fibrolipomatous hamartomas: report of occurrence in half brothers.

    PubMed

    Fangman, William L; Prose, Neil S

    2004-01-01

    Precalcaneal congenital fibrolipomatous hamartomas are uncommon, congenital, nontender papules located on the medial plantar aspects of the heel. We report the occurrence of this rare disorder in two half brothers, suggesting that it may occur in a familial pattern.

  8. 17. Photocopy of Photograph (Original Held by the Manning Brothers ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of Photograph (Original Held by the Manning Brothers Commercial Photographers, Madison Heights, Michigan, Negative No. 38750). SOUTHERN PORTION OF WEST FACADE, LOOKING NORTH, SHOWN ON EXTREME LEFT, 24 NOVEMBER 1920. - Basso Building, 7338 Woodward Avenue, Detroit, MI

  9. 18. Photocopy of Photograph (Original Held by the Manning Brothers ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photocopy of Photograph (Original Held by the Manning Brothers Commercial Photographers, Madison Heights, Michigan, Negative No. 67707). SOUTHERN PORTION OF WEST FACADE, LOOKING EAST, SHOWN ON EXTREME LEFT, 3 June 1925. - Basso Building, 7338 Woodward Avenue, Detroit, MI

  10. Different course of silicosis in four brothers of one family.

    PubMed

    Danila, Edvardas; Sileikiene, Virginija; Nargela, Remigijus; Zurauskas, Edvardas; Loskutoviene, Greta

    2009-01-01

    Silicosis remains a common occupational respiratory disease. Even in this era of highly sophisticated hygiene in European countries, new occupational cases of silicosis continue to be reported. Four cases of silicosis which developed after a relatively short occupational exposure to respirable silica among the members of one family are described. Four young men worked illegally abroad in mining in one of European countries. All of them were employed together in the same working conditions. One of the brothers died due to the acute form of the disease (lipoproteinosis). Two of the brothers suffered from simple nodular silicosis, and the fourth brother developed very early nodular silicosis and small airway dust disease. A one year follow-up revealed moderate/severe worsening of the disease in all surviving brothers.

  11. The Lehman Brothers effect and bankruptcy cascades

    NASA Astrophysics Data System (ADS)

    Sieczka, P.; Sornette, D.; Holyst, J. A.

    2011-08-01

    Inspired by the bankruptcy of Lehman Brothers and its consequences on the global financial system, we develop a simple model in which the Lehman default event is quantified as having an almost immediate effect in worsening the credit worthiness of all financial institutions in the economic network. In our stylized description, all properties of a given firm are captured by its effective credit rating, which follows a simple dynamics of co-evolution with the credit ratings of the other firms in our economic network. The dynamics resembles the evolution of Potts spin-glass with external global field corresponding to a panic effect in the economy. The existence of a global phase transition, between paramagnetic and ferromagnetic phases, explains the large susceptibility of the system to negative shocks. We show that bailing out the first few defaulting firms does not solve the problem, but does have the effect of alleviating considerably the global shock, as measured by the fraction of firms that are not defaulting as a consequence. This beneficial effect is the counterpart of the large vulnerability of the system of coupled firms, which are both the direct consequences of the collective self-organized endogenous behaviors of the credit ratings of the firms in our economic network.

  12. All in the Family: The Sister Study

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

  13. Eruptive history of South Sister, Oregon Cascades

    USGS Publications Warehouse

    Fierstein, J.; Hildreth, W.; Calvert, A.T.

    2011-01-01

    South Sister is southernmost and highest of the Three Sisters, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North Sister is a monotonously mafic edifice as old as middle Pleistocene, Middle Sister a basalt-andesite-dacite cone built between 48 and 14ka, and South Sister is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle Sister). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South Sister lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South Sister - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South Sister's flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the

  14. [Two Dutch sisters in analysis with Freud].

    PubMed

    Stroeken, Harry

    2010-01-01

    The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two sisters, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger sister to seek divorce.

  15. [Congenital insensitivity to pain: clinical and neurophysiological study in three sisters of a Moroccan family].

    PubMed

    Kissani, N; Krrati, H; Alarcon, G; Belaaidi, H; Ouazzani, R

    2013-11-01

    Congenital insensitivity to pain is a rare hereditary sensory and autonomic neuropathy (HSAN). This disorder is an autosomal recessive condition: since 1996, mutations attributed to this entity have been found in the neurotrophin tyrosine-kinase gene receptor on chromosome 1. The authors report 3 cases of congenital insensitivity to pain. In these 3 sisters of consanguineous parents, the clinical investigation showed total absence of pain and temperature sensations with preservation of all other sensory modalities, mental retardation, but in contrast to HSAN type IV, there was no anhidrosis. The neurophysiological investigation revealed an isolated axonal sensory polyneuropathy in the 3 patients. The clinical and neurophysiological investigations were normal in both parents and the brother. The physiopathology of this entity is discussed. We suggest a particular form of HSAN type IV with preservation of transpiration or a new entity of congenital insensitivity to pain, which should be analyzed genetically.

  16. Who Are My Sisters and Brothers? A Catholic Educational Guide for Understanding and Welcoming Immigrants and Refugees.

    ERIC Educational Resources Information Center

    United States Catholic Conference, Washington, DC.

    This educational guide, designed for use in Catholic elementary and secondary schools, religious education programs at all grades, youth retreats, teacher training, or parent and adult sessions, places issues related to immigrants and refugees in a Catholic perspective. It offers some basic materials to use and adapt for children and adults to…

  17. Baby Sister/Baby Brother: Reactions to the Birth of a Sibling and Patterns of Early Sibling Relations.

    ERIC Educational Resources Information Center

    Vandell, Deborah Lowe

    1987-01-01

    Children have a variety of reactions to a sibling birth that includes disruptions in their physical and psychological functioning as well as apparent growth in these same areas. Explores the variety of factors that influence reactions to the sibling's birth and the relationship between the siblings. (BJV)

  18. Family Context and Gender Role Socialization in Middle Childhood: Comparing Girls to Boys and Sisters to Brothers.

    ERIC Educational Resources Information Center

    McHale, Susan M.; Crouter, Ann C.; Tucker, Corinna J.

    1999-01-01

    Examined sex-typing in child personality, interests, and activities as function of traditionality of parents' gender role attitudes and sex composition of sibling dyads. Found that sex-typing was most evident in children's interests and activities. Differences in children's sex-typing as a function of fathers' attitudes and sibling sex…

  19. Triallelic digenic mutation in the prokineticin 2 and GNRH receptor genes in two brothers with normosmic congenital hypogonadotropic hypogonadism.

    PubMed

    Méndez, Juan Pablo; Zenteno, Juan Carlos; Coronel, Agustín; Soriano-Ursúa, Marvin Antonio; Valencia-Villalvazo, Elith Yazmín; Soderlund, Daniela; Coral-Vázquez, Ramón Mauricio; Canto, Patricia

    2015-01-01

    Purpose/aim of the study: To date, different genes have been identified as responsible for the presence of normosmic congenital hypogonadotropic hypogonadism (nCHH). Herein, we report the molecular findings regarding the analysis of PROK2, in two brothers with nCHH. Two siblings with nCHH, in whom mutations in GNRHR, PROKR2 and FGFR1 had been investigated previously, as well as their family were studied. DNA was amplified by PCR and sequenced for the PROK2 gene. Controls were analyzed by restriction fragment-length polymorphism. The structure of PROK2 and its mutant protein were compared using a protein molecular model. Both affected siblings exhibited a heterozygous p.R117W mutation in PROK2, while their mother was a heterozygous carrier and their father, an unaffected brother and their sister were homozygous wild type. Besides, both patients presented a homozygous p.E90K mutation in GNRHR that had been previously reported. We found a novel mutation in PROK2 in two siblings in whom a mutation in the GNRHR gene had been previously reported.

  20. How Big Is Too Big?

    ERIC Educational Resources Information Center

    Cibes, Margaret; Greenwood, James

    2016-01-01

    Media Clips appears in every issue of Mathematics Teacher, offering readers contemporary, authentic applications of quantitative reasoning based on print or electronic media. This issue features "How Big is Too Big?" (Margaret Cibes and James Greenwood) in which students are asked to analyze the data and tables provided and answer a…

  1. How Big Is Too Big?

    ERIC Educational Resources Information Center

    Cibes, Margaret; Greenwood, James

    2016-01-01

    Media Clips appears in every issue of Mathematics Teacher, offering readers contemporary, authentic applications of quantitative reasoning based on print or electronic media. This issue features "How Big is Too Big?" (Margaret Cibes and James Greenwood) in which students are asked to analyze the data and tables provided and answer a…

  2. Sister chromatid segregation in meiosis II

    PubMed Central

    Wassmann, Katja

    2013-01-01

    Meiotic divisions (meiosis I and II) are specialized cell divisions to generate haploid gametes. The first meiotic division with the separation of chromosomes is named reductional division. The second division, which takes place immediately after meiosis I without intervening S-phase, is equational, with the separation of sister chromatids, similar to mitosis. This meiotic segregation pattern requires the two-step removal of the cohesin complex holding sister chromatids together: cohesin is removed from chromosome arms that have been subjected to homologous recombination in meiosis I and from the centromere region in meiosis II. Cohesin in the centromere region is protected from removal in meiosis I, but this protection has to be removed—deprotected”—for sister chromatid segregation in meiosis II. Whereas the mechanisms of cohesin protection are quite well understood, the mechanisms of deprotection have been largely unknown until recently. In this review I summarize our current knowledge on cohesin deprotection. PMID:23574717

  3. Biological versus nonbiological older brothers and men's sexual orientation.

    PubMed

    Bogaert, Anthony F

    2006-07-11

    The most consistent biodemographic correlate of sexual orientation in men is the number of older brothers (fraternal birth order). The mechanism underlying this effect remains unknown. In this article, I provide a direct test pitting prenatal against postnatal (e.g., social/rearing) mechanisms. Four samples of homosexual and heterosexual men (total n = 944), including one sample of men raised in nonbiological and blended families (e.g., raised with half- or step-siblings or as adoptees) were studied. Only biological older brothers, and not any other sibling characteristic, including nonbiological older brothers, predicted men's sexual orientation, regardless of the amount of time reared with these siblings. These results strongly suggest a prenatal origin to the fraternal birth-order effect.

  4. The Seven Sisters Pose for Spitzer

    NASA Image and Video Library

    2007-04-16

    The Seven Sisters, also known as the Pleiades star cluster, seem to float on a bed of feathers in a new infrared image from NASA Spitzer Space Telescope. Clouds of dust sweep around the stars, swaddling them in a cushiony veil.

  5. Family Constellations: Teaching Dave Etter's "Brother" (Modern Poetry in the Classroom).

    ERIC Educational Resources Information Center

    Totherow, Barbara

    1988-01-01

    Discusses how Dave Etter's poem "Brother" involves students by focusing on the themes of guilt and the love/hate complexity of a sibling relationship. Notes that Gina Berriault's story "The Stone Boy" and Harley Elliot's poem "Brothers Together in Winter" work well in conjunction with "Brother" as a thematic…

  6. 75 FR 46864 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Short Brothers PLC... this proposed AD, contact Short Brothers PLC, Airworthiness, P.O. Box 241, Airport Road, Belfast, BT3... new AD: Short Brothers PLC: Docket No. FAA-2010-0225; Directorate Identifier 2009-NM-203-AD....

  7. 75 FR 12154 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Short Brothers PLC... Brothers PLC, Airworthiness, P.O. Box 241, Airport Road, Belfast, BT3 9DZ Northern Ireland; telephone +44(0... 16, 2006) and adding the following new AD: Short Brothers PLC: Docket No. FAA-2010-0225;...

  8. 75 FR 30831 - Cooksey Brothers Landfill Fire Superfund Site; Ashland, Boyd County, KY; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... AGENCY Cooksey Brothers Landfill Fire Superfund Site; Ashland, Boyd County, KY; Notice of Settlement... costs concerning the Cooksey Brothers Landfill Fire Superfund Site located in Ashland, Boyd County... Brothers Landfill Superfund Site by one of the following methods: http://www.regulations.gov : Follow the...

  9. Propaganda in Warner Brothers World War II Cartoons.

    ERIC Educational Resources Information Center

    Machowski, James Stanley; Brown, James William

    To examine the role of the animated cartoon in propaganda associated with World War II, 194 of 262 cartoons produced for theatrical release by Warner Brothers, Inc., from 1939 to 1946 were analyzed. Propaganda content was determined by the number and nature of symbols used and the cartoon's "attitudes" toward these symbols. An analysis…

  10. The brothers Lumière. Pioneers in medical photography.

    PubMed

    Aterman, K; Grimaud, J A

    1983-10-01

    A brief historical sketch of the brothers Lumière, the inventors of the cinématographe, is presented. Particular emphasis is placed on their perfection of "Autochromes," photographic plates suitable for color photography, and on their foresight in putting these advances to use in medical illustrations.

  11. Perspective view of the Hope Brothers Building (Building T), 187 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of the Hope Brothers Building (Building T), 187 Main Street South, view looking northwest - Vale Commercial Historic District, A Street between Holland & Longfellow Streets, north side of B Street between Holland & Main Streets, Main Street South from A Street through B Street, & Stone House at 283 Main Street South, Vale, Malheur County, OR

  12. Propaganda in Warner Brothers World War II Cartoons.

    ERIC Educational Resources Information Center

    Machowski, James Stanley; Brown, James William

    To examine the role of the animated cartoon in propaganda associated with World War II, 194 of 262 cartoons produced for theatrical release by Warner Brothers, Inc., from 1939 to 1946 were analyzed. Propaganda content was determined by the number and nature of symbols used and the cartoon's "attitudes" toward these symbols. An analysis…

  13. Correlation of WAIS IQ in 10 Pairs of Brothers.

    ERIC Educational Resources Information Center

    Matarazzo, Joseph D.; And Others

    1978-01-01

    Pairs of brothers were individually examined with Wechsler Adult Intelligence Scale some 10 months apart by an experienced clinical psychologist unaware of the consanguineous relationship. Correlation of .42 for Full Scale IQ is consistent with median correlation reported by Erlenmeyer-Kimling and Jarvik in their 1963 literature review.…

  14. Big Surveys, Big Data Centres

    NASA Astrophysics Data System (ADS)

    Schade, D.

    2016-06-01

    Well-designed astronomical surveys are powerful and have consistently been keystones of scientific progress. The Byurakan Surveys using a Schmidt telescope with an objective prism produced a list of about 3000 UV-excess Markarian galaxies but these objects have stimulated an enormous amount of further study and appear in over 16,000 publications. The CFHT Legacy Surveys used a wide-field imager to cover thousands of square degrees and those surveys are mentioned in over 1100 publications since 2002. Both ground and space-based astronomy have been increasing their investments in survey work. Survey instrumentation strives toward fair samples and large sky coverage and therefore strives to produce massive datasets. Thus we are faced with the "big data" problem in astronomy. Survey datasets require specialized approaches to data management. Big data places additional challenging requirements for data management. If the term "big data" is defined as data collections that are too large to move then there are profound implications for the infrastructure that supports big data science. The current model of data centres is obsolete. In the era of big data the central problem is how to create architectures that effectively manage the relationship between data collections, networks, processing capabilities, and software, given the science requirements of the projects that need to be executed. A stand alone data silo cannot support big data science. I'll describe the current efforts of the Canadian community to deal with this situation and our successes and failures. I'll talk about how we are planning in the next decade to try to create a workable and adaptable solution to support big data science.

  15. Crocodile Talk: Attributions of Incestuously Abused and Nonabused Sisters.

    ERIC Educational Resources Information Center

    Monahan, Kathleen

    1997-01-01

    This qualitative study analyzed the retrospective attributions of adult sisters (five abused sister dyads, and five abused and nonabused sister dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…

  16. Crocodile Talk: Attributions of Incestuously Abused and Nonabused Sisters.

    ERIC Educational Resources Information Center

    Monahan, Kathleen

    1997-01-01

    This qualitative study analyzed the retrospective attributions of adult sisters (five abused sister dyads, and five abused and nonabused sister dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…

  17. Differences in Two Sisters' Acquisition of First Verbs.

    ERIC Educational Resources Information Center

    Braunwald, Susan R.

    This study examined prior qualitative differences in the process of the emergence of verb use in two sisters when they were each 12 to 24 months of age (the older sister is 2 years and 9 months older than the younger sister). Daily diaries on both children were kept by the mother, who noted emergent structure and vocabulary. Systematic Analysis of…

  18. Suicide pact among three young sisters.

    PubMed

    Altindag, Abdurrahman; Yanik, Medaim

    2005-01-01

    A suicide pact is an agreement between two or more people to kill themselves. They represent 0.6-4.0% of all suicides, the vast majority being double suicides. We present a triple suicide pact involving three young sisters. Atypical features of this case include the number of participants, their young ages, and their good health conditions. Similarities to previously reported cases include participants having family disturbances, histories of depression and borderline personality.

  19. Big Opportunities and Big Concerns of Big Data in Education

    ERIC Educational Resources Information Center

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  20. Big Opportunities and Big Concerns of Big Data in Education

    ERIC Educational Resources Information Center

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  1. Big bluestem

    USDA-ARS?s Scientific Manuscript database

    Big Bluestem (Andropogon gerardii) is a warm season grass native to North America, accounting for 40% of the herbaceous biomass of the tall grass prairie, and a candidate for bioenergy feedstock production. The goal of this study was to measure among and within population genetic variation of natura...

  2. Big Dreams

    ERIC Educational Resources Information Center

    Benson, Michael T.

    2015-01-01

    The Keen Johnson Building is symbolic of Eastern Kentucky University's historic role as a School of Opportunity. It is a place that has inspired generations of students, many from disadvantaged backgrounds, to dream big dreams. The construction of the Keen Johnson Building was inspired by a desire to create a student union facility that would not…

  3. 77 FR 13585 - Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... COMMISSION Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting..., 2012. d. Applicant: Three Sisters Irrigation District. e. Name of Project: Three Sisters Irrigation District Hydroelectric Project. f. Location: The proposed Three Sisters Irrigation District Hydroelectric...

  4. A Unique Case of Allogeneic Fat Grafting Between Brothers

    PubMed Central

    Kim, Samuel; Edelson, Richard L.; Sumpio, Brandon; Kwei, Stephanie

    2016-01-01

    Summary: We present a case of a 65-year-old man with cutaneous T-cell lymphoma treated with radiation therapy and an allogeneic hematopoietic stem cell transplant from his human leukocyte antigen-matched brother. Engraftment was successful, but the patient went on to develop painful, radiation-induced ulcers. The ulcers were fat-allografted using liposuctioned fat from his brother because of the patient’s unique chimeric state. Postprocedure follow-up revealed epithelialization of the ulcer sites and significant improvement in neuropathic pain. Our unique case study supports the use of fat grafting for its restorative purposes and for its ability to alleviate chronic neuropathic pain. Additionally, it appears that our case provides a basis of a general approach to the treatment of radiation-induced ulcers in chimeric patients with lymphoid malignancies. PMID:27757347

  5. Coloured sweat in two brothers: First report of familial chromhidrosis.

    PubMed

    Gaffney, Daniel C; Cooper, Hywel L

    2016-02-01

    The uncommon diagnosis of chromhidrosis is most frequently made in young adults. This sweat gland disease, although benign, may impact significantly on the patient's quality of life. We describe the first report of familial chromhidrosis of pseudo-eccrine type (pseudochromhidrosis) occurring in two brothers aged 9 and 12 years. The classification and causality of chromhidrosis is described and approaches to assessment and management are outlined.

  6. [Metabolic studies in brothers affected by alcaptonuria (ochronosis)].

    PubMed

    Pugge, H R; Orozco, M; Toledo, A; Ripoll, J; Katz, J; Toledo, I; Pellanda, R

    1978-01-01

    The case of two brothers affected by alcaptonurie is reported. The activity of the homogenthisycasa enzyme has been determined by the material obtained through percutaneous biopsy. Concentrations of the aminoacids producing fenilalanina and thiroxina in their parents' blood have been investigated, the tests showing lack of liver enzyme and normal concentration of the amount of aminoacids in blood. Some aspects of skin lesion have been briefly reported and methods for treatment presented.

  7. Ankylosing spondylitis in two Zaïrian brothers.

    PubMed

    Mbuyi-Muamba, J M; Malonda, N; Yuma, O

    1993-06-01

    Ankylosing spondylitis has never been described in Zaïre and is considered to be rare in black African populations. We report two cases observed in the University Hospital of Kinshasa. The two patients are brothers. The diagnosis is based on anaemnestic, clinical and radiological findings. We therefore demonstrate the existence of this disease in Zaïre and presume that other similar cases may be diagnosed.

  8. Evaluation and treatment of familial globozoospermia in five brothers.

    PubMed

    Kilani, Zaid; Ismail, Radwan; Ghunaim, Samer; Mohamed, Hossam; Hughes, David; Brewis, Ian; Barratt, Christopher L R

    2004-11-01

    To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy. Case report. A tertiary center for assisted reproduction. Five siblings with globozoospermia. Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers. Clinical pregnancy and live birth after ICSI treatment. Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses. Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.

  9. George Orwell and Modern Science Fiction: The Legacy of Big Brother.

    ERIC Educational Resources Information Center

    Lerner, Fred

    1984-01-01

    Discusses George Orwell's lack of influence on modern science fiction and presents a selected annotated bibliography of modern science fiction materials depicting a wide variety of totalitarian societies. (MBR)

  10. Colleges Fear Anti-Terrorism Law Could Turn Them into Big Brother.

    ERIC Educational Resources Information Center

    Carlson, Scott; Foster, Andrea L.

    2002-01-01

    Describes how many college officials are confused by the USA Patriot Act, a new anti-terrorism law that may affect campus networks and library records; they believe its provisions could raise privacy and academic freedom issues. (EV)

  11. Big Brother and the National Reading Curriculum: How Ideology Trumped Evidence.

    ERIC Educational Resources Information Center

    Allington, Richard

    This book about reading tracks and questions the 30-year campaign that has focused on testing, accountability, and federalization of education to demonstrate that it is not just whole language advocates who are having problems with the National Reading Panel report and the new education laws. The book gathers together a comprehensive collection of…

  12. Big brother - a fully automated control system for the DELPHI experiment

    SciTech Connect

    Franek, B.; Sekulin, R.; Doenszelmann, M.; Gasper, C.; Charpentier, Jonker, M.

    1994-12-31

    The integrated control system of the DELPHI experiment is described. It allows the data to be taken in an almost automatic fashion. This is achieved by computer monitoring of the states of the LEP machine, the DELPHI subdetectors (SC) and the Data Acquisition System (DAS). Depending on these states, computer initiated actions are then taken. It has been designed using {open_quote}State Manager{close_quote} concept already used for local and central controls of DAS and SC.

  13. Big Brother Is Helping You: Supporting Self-Access Language Learning with a Student Monitoring System

    ERIC Educational Resources Information Center

    Reinders, Hayo

    2007-01-01

    Self-access and language advising are relatively recent and increasingly common types of language support offered in schools and tertiary institutions around the world. There is a great deal of anecdotal support for the positive contribution of such support to student learning. Self-access and language advising hold strong potential as…

  14. George Orwell and Modern Science Fiction: The Legacy of Big Brother.

    ERIC Educational Resources Information Center

    Lerner, Fred

    1984-01-01

    Discusses George Orwell's lack of influence on modern science fiction and presents a selected annotated bibliography of modern science fiction materials depicting a wide variety of totalitarian societies. (MBR)

  15. The blood platelets contribution to innate host defense - what they have learned from their big brothers.

    PubMed

    Zander, Dorit M W; Klinger, Matthias

    2009-06-01

    Bactericidal effects of blood platelets have been known for more than 120 years, but the underlying mechanisms are largely obscure. Keeping in mind structural and functional analogies of platelets to neutrophils, three different mechanisms are thinkable: Engulfment of pathogens, release of microbicidal proteins, and production of reactive oxygen species (ROS). Here, we focus on the release of ROS and a possible contribution of blood plasma and thrombin to the bactericidal effects. Killing of bacteria was evaluated by DNA fluorescence labeling and electron microscopy. Release of ROS by platelets was measured photometrically by cytochrome C and phenol red/peroxidase assays and was further evaluated by topological methods. We found that (i) platelets produce 1500 times less O(2) (-) and 4000 times less H(2)O(2) compared to neutrophils, (ii) ROS do not affect the killing rates, and (iii) no local enrichment of ROS was detectable. On the other hand, thrombin and plasma proteins with a molecular mass of >100 kDa are essential for bactericidal effects. We suggest that platelets contribute to the innate host defense by providing a catalytical surface for synthesis of thrombin. In the presence of a heat-instable plasma protein, thrombin may generate a strong bactericidal complex, which is only effective in close vicinity to the platelet membrane.

  16. Big Brother and the National Reading Curriculum: How Ideology Trumped Evidence.

    ERIC Educational Resources Information Center

    Allington, Richard

    This book about reading tracks and questions the 30-year campaign that has focused on testing, accountability, and federalization of education to demonstrate that it is not just whole language advocates who are having problems with the National Reading Panel report and the new education laws. The book gathers together a comprehensive collection of…

  17. When big brother is watching: goal orientation shapes reactions to electronic monitoring during online training.

    PubMed

    Watson, Aaron M; Foster Thompson, Lori; Rudolph, Jane V; Whelan, Thomas J; Behrend, Tara S; Gissel, Amanda L

    2013-07-01

    Web-based training is frequently used by organizations as a convenient and low-cost way to teach employees new knowledge and skills. As web-based training is typically unproctored, employees may be held accountable to the organization by computer software that monitors their behaviors. The current study examines how the introduction of electronic performance monitoring may provoke negative emotional reactions and decrease learning among certain types of e-learners. Through motivated action theory and trait activation theory, we examine the role of performance goal orientation when e-learners are exposed to asynchronous and synchronous monitoring. We show that some e-learners are more susceptible than others to evaluation apprehension when they perceive their activities are being monitored electronically. Specifically, e-learners higher in avoid performance goal orientation exhibited increased evaluation apprehension if they believed asynchronous monitoring was present, and they showed decreased skill attainment as a result. E-learners higher on prove performance goal orientation showed greater evaluation apprehension if they believed real-time monitoring was occurring, resulting in decreased skill attainment.

  18. Brown and polar bear Y chromosomes reveal extensive male-biased gene flow within brother lineages.

    PubMed

    Bidon, Tobias; Janke, Axel; Fain, Steven R; Eiken, Hans Geir; Hagen, Snorre B; Saarma, Urmas; Hallström, Björn M; Lecomte, Nicolas; Hailer, Frank

    2014-06-01

    Brown and polar bears have become prominent examples in phylogeography, but previous phylogeographic studies relied largely on maternally inherited mitochondrial DNA (mtDNA) or were geographically restricted. The male-specific Y chromosome, a natural counterpart to mtDNA, has remained underexplored. Although this paternally inherited chromosome is indispensable for comprehensive analyses of phylogeographic patterns, technical difficulties and low variability have hampered its application in most mammals. We developed 13 novel Y-chromosomal sequence and microsatellite markers from the polar bear genome and screened these in a broad geographic sample of 130 brown and polar bears. We also analyzed a 390-kb-long Y-chromosomal scaffold using sequencing data from published male ursine genomes. Y chromosome evidence support the emerging understanding that brown and polar bears started to diverge no later than the Middle Pleistocene. Contrary to mtDNA patterns, we found 1) brown and polar bears to be reciprocally monophyletic sister (or rather brother) lineages, without signals of introgression, 2) male-biased gene flow across continents and on phylogeographic time scales, and 3) male dispersal that links the Alaskan ABC islands population to mainland brown bears. Due to female philopatry, mtDNA provides a highly structured estimate of population differentiation, while male-biased gene flow is a homogenizing force for nuclear genetic variation. Our findings highlight the importance of analyzing both maternally and paternally inherited loci for a comprehensive view of phylogeographic history, and that mtDNA-based phylogeographic studies of many mammals should be reevaluated. Recent advances in sequencing technology render the analysis of Y-chromosomal variation feasible, even in nonmodel organisms. © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e

  19. Regulation of sister chromatid cohesion during the mitotic cell cycle.

    PubMed

    Zheng, Ge; Yu, HongTao

    2015-11-01

    Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.

  20. An incest case with three biological brothers as alleged fathers: Even 22 autosomal STR loci analysis would not suffice without the mother.

    PubMed

    Canturk, Kemal Murat; Emre, Ramazan; Gurkan, Cemal; Komur, Ilhami; Muslumanoglu, Omer; Dogan, Muhammed

    2016-07-01

    Here, we report an incest paternity case involving three biological brothers as alleged fathers (AFs), their biological sister and her child that was investigated using the Investigator ESSplex Plus, AmpFLSTR Identifiler Plus/Investigator IDplex Plus and PowerPlex 16 kits. Initial duo paternity investigations using 15-loci autosomal short tandem repeat (STR) analyses failed to exclude any of the AFs. Despite the fact that one of the brothers, AF1, had a mismatch with the child at a single locus (D2S1338), the possibility of a single-step mutation could not be ruled out. When the number of autosomal STR loci analysed was increased to 22 without the inclusion of the mother, AF2 and AF3 still could not be excluded, since both of them again had no mismatches with the child. A breakthrough was possible only upon inclusion of the mother so that trio paternity investigations were carried out. This time AF1 and AF2 could be excluded at two loci (D2S1338 and D1S1656) and six loci (vWa, D1S1656, D12S391, FGA, PENTA E and PENTA D), respectively, and AF3 was then the only brother who could not be excluded from paternity. Subsequent statistical analyses suggested that AF3 could be the biological father of the child with a combined paternity index >100 billion and a probability of paternity >99.99999999%. These findings consolidate the fact that complex paternity cases such as those involving incest could benefit more from the inclusion of the mother than simply increasing the number of STR loci analysed. © The Author(s) 2015.

  1. Primary osteosarcoma of the distal femur in two consecutive brothers.

    PubMed

    Chin, K R; Mankin, H J; Gebhardt, M C

    2001-01-01

    The following report describes two consecutive brothers from a nonimmigrant family, with no identifiable predisposing factors, who presented with osteosarcomas of their distal femurs, one at the age of 18 years and the other at the age of 21 years. Until a cost-effective program is developed to screen for osteosarcoma, a detailed family history should be obtained from every new patient with osteosarcoma and parents should be urged to schedule early evaluations of siblings with complaints of painful extremities. Increased frequency of cytogenetic studies to screen for genetic abnormalities in patients with osteosarcoma is recommended to help elucidate the cause of osteosarcoma.

  2. EarthLabs Meet Sister Corita Kent

    NASA Astrophysics Data System (ADS)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  3. Novel insertion in exon 5 of the TCOF1 gene in twin sisters with Treacher Collins syndrome.

    PubMed

    Marszałek-Kruk, Bożena Anna; Wójcicki, Piotr; Smigiel, Robert; Trzeciak, Wiesław H

    2012-08-01

    Treacher Collins syndrome (TCS) is associated with an abnormal differentiation of the first and second pharyngeal arches during fetal development. This causes mostly craniofacial deformities, which require numerous corrective surgeries. TCS is an autosomal dominant disorder and it occurs in the general population at a frequency of 1 in 50,000 live births. The syndrome is caused by mutations in the TCOF1 gene, which encodes the serine/alanine-rich protein named Treacle. Over 120 mutations of the TCOF1 gene responsible for TCS have been described. About 70% of recognized mutations are deletions, which lead to a frame shift, formation of a termination codon, and shortening of the protein product of the gene. Herewith, a new heterozygotic insertion, c.484_668ins185bp, was described in two monozygotic twin sisters suffering from TCS. This mutation was absent in their father, brother, and uncle, indicating a de novo origin. The insertion causes a shift in the reading frame and premature termination of translation at 167 aa. The novel insertion is the longest ever found in the TCOF1 gene and the only one found among monozygotic twin sisters.

  4. Mosaic pattern of sucrase isomaltase deficiency in two brothers.

    PubMed

    Reinshagen, Konrad; Keller, Klaus M; Haase, Bianca; Leeb, Tosso; Naim, Hassan Y; Zimmer, Klaus P

    2008-01-01

    The pathophysiology of mucosal changes observed in infants with chronic protracted diarrhea is poorly understood. We report on two brothers suffering from a special form of sucrase isomaltase (SI) deficiency. The children presented with weight loss and dyspepsia after sucrose exposition. We performed an H respiration test, which showed a pathologic result in the younger brother. Analysis of the brush border enzyme activities showed low expression of lactase and SI. Immunoelectron microscopy of duodenal biopsies showed an isolated SI deficiency in a mosaic pattern [e.g., 42% (14%) crypt enterocytes and 64% (59%) villus enterocytes with decreased amounts of SI on microvilli], whereas lactase and aminopeptidase n (ApN) were present at the apical membrane of all cells in a normal range. The SI mosaic pattern of these patients shows that the enterocytes contain low amounts of SI on the apical membrane but express normal quantities of other disaccharidases. These findings suggest the existence of different clonal expressions or specific (posttranslational) mechanisms of postGolgi transportation for individual brush border enzymes. It remains unresolved whether the mosaic distribution is part of a normal maturation process or caused by a lack of an overall control mechanism in the expression of brush border hydrolases.

  5. Human factors of powered flight: the Wright brothers' contributions.

    PubMed

    Mohler, Stanley R

    2004-02-01

    Orville and Wilbur Wright of Dayton, OH, not only were the first to fly a powered aircraft, but also pioneered many human factors considerations. While others tried to develop aircraft with a high degree of aerodynamic stability, the Wrights intentionally designed unstable aircraft with "cerebralized" control modeled on bird flight. During 1901-03, the brothers worked with large gliders at Kill Devil Hills, near Kitty Hawk, NC, to develop the first practical human-interactive controls for aircraft pitch, roll, and yaw. On December 17, 1903, they made four controlled, powered flights over the dunes at Kitty Hawk with their Wright Flyer. During the next 2 yr, the Wrights made numerous flights in the Wright Flyers II and III at Huffman Prairie near Dayton. They later developed practical in-flight control of engine power, plus an angle-of-attack sensor and stick-pusher that reduced pilot workload. The brothers' flight demonstrations in the U.S. and Europe during 1908-09 awakened the world to the new age of controlled flight. Orville was the first aviator to use a seat belt. He also introduced a rudder boost/trim control that gave the pilot greater control authority. The Wrights' flight training school in Dayton included a flight simulator of their own design. The Wrights patented their practical airplane and flight control concepts, many of which are still in use today.

  6. [Concordant deuteranomaly in monozygotic twin sisters (author's transl)].

    PubMed

    Franceschetti, A T; Klein, D; Dieterle, P

    1976-12-01

    Colorblind twin sisters were born from the marriage of a hemizygote with a carrier for colorblindness. The proof of monozygosity is given by the blood-group typing and the dermatoglyphs. The deuteranomaly is of the same degree in each but is more marked in one of the sisters. The mother has none of the microsymptoms sometimes found in carriers.

  7. Continuity & Change in Catholic Education: An Ethnography of Christian Brothers College. Research Monograph No. 1.

    ERIC Educational Resources Information Center

    Bates, Richard; And Others

    Four papers on an ethnographic study of Christian Brothers College (CBC) in Australia, a Catholic college, are presented. In "Christian Brothers College: A View from Overseas," Louis M. Smith discusses research methods, the religious ethos, faculty heterogeneity, diversity in classroom organization, the organizational context of the…

  8. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Hansen, Jennifer; Martin, Cam

    2007-01-01

    Viewgraphs showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  9. Gliding Experiments of the Wright Brothers: Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Cole, Jennifer Hansen; Martin, John Campbell

    2011-01-01

    Presentation showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905, Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  10. Pregnant and parenting adolescents and their younger sisters: the influence of relationship qualities for younger sister outcomes.

    PubMed

    East, P L; Shi, C R

    1997-04-01

    On the basis of social modeling theory and a sibling interaction hypothesis, it was hypothesized that specific relationship qualities between a pregnant or parenting teen and her younger sister would be associated with permissive younger sister outcomes, such as permissive childbearing attitudes and permissive sexual behavior. Results indicated that negative relationship qualities, such as rivalry, competition, and conflict, were more closely related to younger sisters engaging in problem delinquent-like behavior and sexual behavior than were positive relationship qualities, such as warmth and closeness. Additionally, a shared friendship network with the older sister was found to be associated with extensive younger sister problem behavior and sexual behavior. Three potential explanatory processes are discussed.

  11. Creating Sister Cities: An Exchange Across Hemispheres

    NASA Astrophysics Data System (ADS)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  12. Christ-siemens-touraine syndrome: case report of 2 brothers.

    PubMed

    Vora, Rita V; Anjaneyan, Gopikrishnan; Chaudhari, Arvind; Pilani, Abhishek P

    2014-10-01

    Ectodermal dysplasia is a rare disorder. Christ-Siemens-Touraine syndrome (Hypohidrotic Ectodermal dysplasia (HED)) is a diffuse, non-progressive disease present at birth and involves at least two tissues of ectodermal origin. It is caused by mutation in gene ectodysplasin (EDA, EDA1) located at Xq12-13. Main clinical feature of HED is sparse or absent eccrine gland as well as hypotrichosis, nail, and teeth abnormality with characteristic faces. The absence or diminished activity of sweat gland results in patients having more chances of developing hyperthermia and with intolerance to warm environment. Most do well with simple measures such as wet clothes, air conditioning, wet bands etc. We present cases of two brothers, born of non-consanguineous marriage, who presented to us with complaints of heat intolerance and abnormal facial features.

  13. [History of the Cracow Brothers of Mercy Hospital].

    PubMed

    Gaertner, H

    1995-01-01

    The oldest of existing Cracow hospitals was founded in 1609. The paper discusses the origins, development and decay of the hospital-cloister in its first seat at St. John's and St. Mark's streets. Later the author describes the fate of the hospital-cloister from 1812 after its translocation to the second residence at the Krakowska street. In 1906 the third seat became a new buildings' complex at the Trynitarska street. The work remembers the role of the hospital during several epidemies, Ist and IInd World War and its activity during peace times. The author emphasizes the great merits of Brothers of Mercy for Cracow medicine and hospital system in bringing medical and charitable help to sick and poor.

  14. Breast cancer after Hodgkin's disease in two sisters

    SciTech Connect

    Li, F.P.; Corkery, J.; Canellos, G.; Neitlich, H.W.

    1981-01-01

    Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.

  15. A non-sister act: recombination template choice during meiosis.

    PubMed

    Humphryes, Neil; Hochwagen, Andreas

    2014-11-15

    Meiotic recombination has two key functions: the faithful assortment of chromosomes into gametes and the creation of genetic diversity. Both processes require that meiotic recombination occurs between homologous chromosomes, rather than sister chromatids. Accordingly, a host of regulatory factors are activated during meiosis to distinguish sisters from homologs, suppress recombination between sister chromatids and promote the chromatids of the homologous chromosome as the preferred recombination partners. Here, we discuss the recent advances in our understanding of the mechanistic basis of meiotic recombination template choice, focusing primarily on developments in the budding yeast, Saccharomyces cerevisiae, where the regulation is currently best understood.

  16. Horsetails are the sister group to all other monilophytes and Marattiales are sister to leptosporangiate ferns.

    PubMed

    Knie, Nils; Fischer, Simon; Grewe, Felix; Polsakiewicz, Monika; Knoop, Volker

    2015-09-01

    The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the sister clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes. Both introns have orthologues in seed plants where nad2i542g2 has evolved into a trans-arrangement. In contrast and despite substantial size extensions to more than 5kb in Psilotum, nad2i542g2 remains cis-arranged in the monilophytes. For phylogenetic analyses, we filled taxonomic gaps in previously investigated mitochondrial (atp1, nad5) and chloroplast (atpA, atpB, matK, rbcL, rps4) loci and created a 9-gene matrix that also included the new mitochondrial nad2 and rpl2 loci. We extended the taxon sampling with two taxa each for all land plant outgroups (liverworts, mosses, hornworts, lycophytes and seed plants) to minimize the risk of phylogenetic artefacts. We ultimately obtained a well-supported molecular phylogeny placing Marattiales as sister to leptosporangiate ferns and horsetails as sister to all remaining monilophytes. In addition, an indel in an exon of the here introduced rpl2 locus independently supports the placement of horsetails. We conclude that under dense taxon sampling, phylogenetic information from a prudent choice of loci is currently superior to character-rich phylogenomic approaches at low taxon sampling. As here shown the selective choice of loci and taxa enabled us to resolve the long-enigmatic diversifications of the earliest monilophyte lineages.

  17. Mixed pineal mature teratoma and germinoma in two brothers of the fraternal triplets.

    PubMed

    Grahovac, Gordan; Alden, Tord; Nitin, Wadhwani

    2017-05-01

    Intracranial teratomas are rare germ cell neoplasms that contain tissues derived from all three germ cell layers and most commonly occurring during childhood. This is the first report of pineal region mixed mature teratoma and germinoma in two fraternal brothers of fraternal triplets. We report the case of a mixed mature teratoma and germinoma of the pineal region in two brothers of fraternal triplets. Older brother was initially diagnosed at the age of 11 years with the pure teratoma of the pineal region but the review of the pathology 3 years after initial surgery revealed the mixed mature teratoma with 5% germinomatous component. The younger brother was diagnosed at the age of 13 years with the mixed mature teratoma with 10% germinomatous component tumor of the pineal region. Younger brother has been treated with adjuvant chemo-radiotherapy and older brother was treated without adjuvant therapy. Both brothers had no recurrence. Pineal mature teratomas have a good prognosis, in contrast to their immature or mixed counterparts. A rigorous histological examination of the tumor samples is mandatory, in order to not omit a mixed contingent within the tumor.

  18. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2008-01-01

    This viewgraph presentation reviews the Wright Brothers's flight research during the 10 years between 1899 and 1908. The Wright Brothers began their research in flight with gliders. The presentation shows pictures, replicas and characteristics of the gliders that the Wright Brothers used. This presentation is not just a history lesson. In the end it investigates "What Does Flight Research Accomplish?" Flight research can serve many uses, such as Separates the Real from the Imagined, Uncovers the Unexpected and the Overlooked, Forces the Realistic Integration of the Pilot, Forces the Development of Reliable Prediction and Test Processes, Requires Every Problem to Be Addressed, Promotes Technology Transfer, and Builds a Core Technical Team,

  19. cBrother: relaxing parental tree assumptions for Bayesian recombination detection.

    PubMed

    Fang, Fang; Ding, Jing; Minin, Vladimir N; Suchard, Marc A; Dorman, Karin S

    2007-02-15

    Bayesian multiple change-point models accurately detect recombination in molecular sequence data. Previous Java-based implementations assume a fixed topology for the representative parental data. cBrother is a novel C language implementation that capitalizes on reduced computational time to relax the fixed tree assumption. We show that cBrother is 19 times faster than its predecessor and the fixed tree assumption can influence estimates of recombination in a medically-relevant dataset. cBrother can be freely downloaded from http://www.biomath.org/dormanks/ and can be compiled on Linux, Macintosh and Windows operating systems. Online documentation and a tutorial are also available at the site.

  20. Analysis of the Lehman Brothers collapse and the Flash Crash event by applying wavelets methodologies

    NASA Astrophysics Data System (ADS)

    Beccar-Varela, Maria P.; Mariani, Maria C.; Tweneboah, Osei K.; Florescu, Ionut

    2017-05-01

    In this study, we apply a wavelet methodology initially developed for geophysical data to financial data. Specifically, the method distinguishes between natural tectonic earthquakes and man made explosions. We exemplify using time series data from two financial events: the Lehman Brothers collapse and the Flash Crash event. We conclude that the Lehman Brothers collapse behaves like a natural earthquake while the Flash Crash event behaves like a human made explosion. This study may imply that the Lehman Brothers type events may be predicted, while sudden Flash Crash type events are not predictable.

  1. 38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal conveyor, blast stoves, "A" furnace, stoves, "B" furnace, stoves, "C" furnace, bottle cars. Looking south - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  2. How-to-Do-It: Demonstrating Sister Chromatid Exchanges.

    ERIC Educational Resources Information Center

    Dye, Frank J.

    1988-01-01

    Outlines procedures for demonstrating and preparing a permanent slide of sister chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)

  3. Sister kinetochores are mechanically fused during meiosis I in yeast.

    PubMed

    Sarangapani, Krishna K; Duro, Eris; Deng, Yi; Alves, Flavia de Lima; Ye, Qiaozhen; Opoku, Kwaku N; Ceto, Steven; Rappsilber, Juri; Corbett, Kevin D; Biggins, Sue; Marston, Adèle L; Asbury, Charles L

    2014-10-10

    Production of healthy gametes requires a reductional meiosis I division in which replicated sister chromatids comigrate, rather than separate as in mitosis or meiosis II. Fusion of sister kinetochores during meiosis I may underlie sister chromatid comigration in diverse organisms, but direct evidence for such fusion has been lacking. We used laser trapping and quantitative fluorescence microscopy to study native kinetochore particles isolated from yeast. Meiosis I kinetochores formed stronger attachments and carried more microtubule-binding elements than kinetochores isolated from cells in mitosis or meiosis II. The meiosis I-specific monopolin complex was both necessary and sufficient to drive these modifications. Thus, kinetochore fusion directs sister chromatid comigration, a conserved feature of meiosis that is fundamental to Mendelian inheritance.

  4. Developing skills in clinical leadership for ward sisters.

    PubMed

    Fenton, Katherine; Phillips, Natasha

    The Francis report has called for a strengthening of the ward sister's role. It recommends that sisters should operate in a supervisory capacity and should not be office bound. Effective ward leadership has been recognised as being vital to high-quality patient care and experience, resource management and interprofessional working. However, there is evidence that ward sisters are ill equipped to lead effectively and lack confidence in their ability to do so. University College London Hospitals Foundation Trust has recognised that the job has become almost impossible in increasingly large and complex organisations. Ward sisters spend less than 40% of their time on clinical leadership and the trust is undertaking a number of initiatives to support them in this role.

  5. UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED TO OLDER BEAMS, NEW STRINGERS AND COMPONENTS MAKE UP A NEARLY NEW SUPPORT SYSTEM - Short Bridge, Spanning South Santiam River at High Deck Road, Cascadia, Linn County, OR

  6. How-to-Do-It: Demonstrating Sister Chromatid Exchanges.

    ERIC Educational Resources Information Center

    Dye, Frank J.

    1988-01-01

    Outlines procedures for demonstrating and preparing a permanent slide of sister chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)

  7. Agenesis of the Corpus Callosum in Two Sisters

    PubMed Central

    Shapira, Yehuda; Cohen, Tirza

    1973-01-01

    Two sisters are described. They are offspring of Arabic parents who are both first and second cousins, through both sets of grandparents; additionally the father's parents are first cousins. The diagnosis of agenesis of the corpus callosum in the propositae was made by the characteristic picture on the pneumoencephalogram. The clinical symptoms in the two sisters varied considerably. The older sister had shown delayed psychomotor development in infancy, mild mental retardation, and developed seizures at 7 years of age of both the grand mal and akinetic types. Her physical and neurological examination did not show any abnormalities. The EEG was severely abnormal with slow wave activity over the posterior parts of the brain and focal spiking. The younger sister presented at 6 months of age with failure to thrive, generalized hypotonia, but without seizures. Her EEG was within normal limits. This anomaly was probably transmitted by an autosomal recessive gene. The clinical and genetic aspects of this syndrome are discussed. Images PMID:4204338

  8. Linking chromosome duplication and segregation via sister chromatid cohesion.

    PubMed

    Leman, Adam R; Noguchi, Eishi

    2014-01-01

    DNA replication during S phase generates two identical copies of each chromosome. Each chromosome is destined for a daughter cell, but each daughter must receive one and only one copy of each chromosome. To ensure accurate chromosome segregation, eukaryotic cells are equipped with a mechanism to pair the chromosomes during chromosome duplication and hold the pairs until a bi-oriented mitotic spindle is formed and the pairs are pulled apart. This mechanism is known as sister chromatid cohesion, and its actions span the entire cell cycle. During G1, before DNA is copied during S phase, proteins termed cohesins are loaded onto DNA. Paired chromosomes are held together through G2 phase, and finally the cohesins are dismantled during mitosis. The processes governing sister chromatid cohesion ensure that newly replicated sisters are held together from the moment they are generated to the metaphase-anaphase transition, when sisters separate.

  9. Sister chromatid decatenation: bridging the gaps in our knowledge

    PubMed Central

    Broderick, Ronan; Niedzwiedz, Wojciech

    2015-01-01

    Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process. PMID:26266709

  10. Two sisters resembling Gorlin-Chaudhry-Moss syndrome.

    PubMed

    Aravena, Teresa; Passalacqua, Cristóbal; Pizarro, Oscar; Aracena, Mariana

    2011-10-01

    The Gorlin-Chaudhry-Moss syndrome (GCMS), was describe initially by Gorlin et al. [Gorlin et al. (1960)] in two sisters with craniosynostosis, hypertrichosis, hypoplastic labia majora, dental defects, eye anomalies, patent ductus arteriosus, and normal intelligence. Two other sporadic instances have been documented. Here, we report on two sisters with a condition with some similarities to GCMS as well as some differences, which could represent either previously unreported variability in GCMS, or it may represent a novel disorder.

  11. Doing What Your Big Sister Does: Sex, Postfeminism and the YA Chick Lit Series

    ERIC Educational Resources Information Center

    Bullen, Elizabeth; Toffoletti, Kim; Parsons, Liz

    2011-01-01

    Mass-marketed teen chick lit has become a publishing phenomenon and has begun to attract critical interest among children's literature scholars. Much of this critical work, however, has shied away from robust critical assessment of the postfeminist conditions informing the production and reception of young adult series like Private, Gossip Girl…

  12. Doing What Your Big Sister Does: Sex, Postfeminism and the YA Chick Lit Series

    ERIC Educational Resources Information Center

    Bullen, Elizabeth; Toffoletti, Kim; Parsons, Liz

    2011-01-01

    Mass-marketed teen chick lit has become a publishing phenomenon and has begun to attract critical interest among children's literature scholars. Much of this critical work, however, has shied away from robust critical assessment of the postfeminist conditions informing the production and reception of young adult series like Private, Gossip Girl…

  13. Big Data, Big Problems: A Healthcare Perspective.

    PubMed

    Househ, Mowafa S; Aldosari, Bakheet; Alanazi, Abdullah; Kushniruk, Andre W; Borycki, Elizabeth M

    2017-01-01

    Much has been written on the benefits of big data for healthcare such as improving patient outcomes, public health surveillance, and healthcare policy decisions. Over the past five years, Big Data, and the data sciences field in general, has been hyped as the "Holy Grail" for the healthcare industry promising a more efficient healthcare system with the promise of improved healthcare outcomes. However, more recently, healthcare researchers are exposing the potential and harmful effects Big Data can have on patient care associating it with increased medical costs, patient mortality, and misguided decision making by clinicians and healthcare policy makers. In this paper, we review the current Big Data trends with a specific focus on the inadvertent negative impacts that Big Data could have on healthcare, in general, and specifically, as it relates to patient and clinical care. Our study results show that although Big Data is built up to be as a the "Holy Grail" for healthcare, small data techniques using traditional statistical methods are, in many cases, more accurate and can lead to more improved healthcare outcomes than Big Data methods. In sum, Big Data for healthcare may cause more problems for the healthcare industry than solutions, and in short, when it comes to the use of data in healthcare, "size isn't everything."

  14. Dyke-Davidoff-Masson Syndrome: Cases of Two Brothers and Literature Review

    PubMed Central

    Park, Kyung-Il; Chung, Jae-Myun; Kim, Ji-Young

    2014-01-01

    Dyke-Davidoff-Masson syndrome (DDMS) has cerebral hemiatrophy and compensatory ipsilateral skull thickening, and is manifested by recurrent seizures and hemiparesis. We present one case with typical DDMS, who had a brother suffering from epilepsy with mild imaging abnormality relevant to DDMS and similar seizure semiology. A 26-year-old man had a history of developmental delay, mental retardation, hemiparesis and recurrent seizures. His brother, 23-year-old man had also experienced recurrent seizures, but he had no neurological deficits. Older brother experienced focal motor seizures with/without secondary generalization. Sometimes, he noted an auditory aura. MRI demonstrated the hemispheric atrophy with the adjacent bony hypertrophy. The seizures of younger brother were mainly of the auditory type and the MRI showed mild hemispheric atrophy with hippocampal sclerosis without any bony change. Our sibling cases might have a familial predisposition and support the idea that clinical courses and radiological findings of DDMS are varied even within one family. PMID:24977128

  15. Dyke-davidoff-masson syndrome: cases of two brothers and literature review.

    PubMed

    Park, Kyung-Il; Chung, Jae-Myun; Kim, Ji-Young

    2014-06-01

    Dyke-Davidoff-Masson syndrome (DDMS) has cerebral hemiatrophy and compensatory ipsilateral skull thickening, and is manifested by recurrent seizures and hemiparesis. We present one case with typical DDMS, who had a brother suffering from epilepsy with mild imaging abnormality relevant to DDMS and similar seizure semiology. A 26-year-old man had a history of developmental delay, mental retardation, hemiparesis and recurrent seizures. His brother, 23-year-old man had also experienced recurrent seizures, but he had no neurological deficits. Older brother experienced focal motor seizures with/without secondary generalization. Sometimes, he noted an auditory aura. MRI demonstrated the hemispheric atrophy with the adjacent bony hypertrophy. The seizures of younger brother were mainly of the auditory type and the MRI showed mild hemispheric atrophy with hippocampal sclerosis without any bony change. Our sibling cases might have a familial predisposition and support the idea that clinical courses and radiological findings of DDMS are varied even within one family.

  16. Proposed Consent Agreement and Final Order: Wood Brothers Trucking & Construction and Jason Carnahan

    EPA Pesticide Factsheets

    EPA's proposed Consent Agreement and Final Order in the matter of Wood Brothers Trucking & Construction and Jason Carnahan for violations of the Clean Water Act at their construction site located outside of Boise, Idaho.

  17. Proposed Penalty Against Wood Brothers Trucking & Construction and Jason Carnahan for Clean Water Act Violations

    EPA Pesticide Factsheets

    Public notice of EPA's proposed penalty against Wood Brothers Trucking & Construction and Jason Carnahan for violations of the Clean Water Act at their construction site located outside of Boise, Idaho.

  18. Performance of older versus younger brothers: data from major league baseball.

    PubMed

    Abel, Ernest L; Kruger, Michael L

    2007-12-01

    Batting and pitching records and career lengths of 312 sets of brothers who became major league baseball players were compared. Older brothers at non-pitching positions (N = 262) had significantly higher batting averages and longer careers than their younger siblings. Differences for pitchers were not statistically significant. The results corroborate other studies that firstborns are more likely than later born siblings to be higher achievers, but different factors may be operative for pitchers.

  19. Five Big Ideas

    ERIC Educational Resources Information Center

    Morgan, Debbie

    2012-01-01

    Designing quality continuing professional development (CPD) for those teaching mathematics in primary schools is a challenge. If the CPD is to be built on the scaffold of five big ideas in mathematics, what might be these five big ideas? Might it just be a case of, if you tell me your five big ideas, then I'll tell you mine? Here, there is…

  20. Five Big Ideas

    ERIC Educational Resources Information Center

    Morgan, Debbie

    2012-01-01

    Designing quality continuing professional development (CPD) for those teaching mathematics in primary schools is a challenge. If the CPD is to be built on the scaffold of five big ideas in mathematics, what might be these five big ideas? Might it just be a case of, if you tell me your five big ideas, then I'll tell you mine? Here, there is…

  1. Geographic variance of cardiovascular risk factors among community women: the national Sister to Sister campaign.

    PubMed

    Jarvie, Jennifer L; Johnson, Caitlin E; Wang, Yun; Wan, Yun; Aslam, Farhan; Athanasopoulos, Leonidas V; Pollin, Irene; Foody, JoAnne M

    2011-01-01

    There are substantial variations in cardiovascular disease (CVD) risk and outcomes among women. We sought to determine geographic variation in risk factor prevalence in a contemporary sample of U.S. women. Using 2008-2009 Sister to Sister (STS) free heart screening data from 17 U.S. cities, we compared rates of obesity (body mass index [BMI] ≥30 kg/m(2)), hypertension (HTN ≥140/90 mm Hg), low high-density lipoprotein cholesterol (HDL-C <40 mg/dL), and hyperglycemia (≥126 mg/dL) with national rates. In 18,892 women (mean age 49.8 ± 14.3 years, 37% black, 32% white, 14% Hispanic), compared to overall STS rates, significantly higher rates were observed for obesity in Baltimore (42.4%), Atlanta (40.0%), Dallas (37.9%), and Jacksonville (36.0%); for HTN in Atlanta (43.9%), Baltimore (42.5%), and New York (39.1%); for hyperglycemia in Jacksonville (20.3%), Philadelphia (18.1%), and Tampa (17.8%); and for HDL-C <40 mg/dL in Phoenix (37.4%), Dallas (26.5%), and Jacksonville (18.1%). Compared to national American Heart Association (AHA) 2010 update rates, most STS cities had higher rates of hyperglycemia and low HDL-C. In a large, community-based sample of women nationwide, this comprehensive analysis shows remarkable geographic variation in risk factors, which provides opportunities to improve and reduce a woman's CVD risk. Further investigation is required to understand the reasons behind such variation, which will provide insight toward tailoring preventive interventions to narrow gaps in CVD risk reduction in women.

  2. The Montgolfier Brothers and the Invention of Aviation

    NASA Astrophysics Data System (ADS)

    Moore, Charles B.

    The first hot air balloon ascension over Paris in September 1783 has been described so many times that it and its passengers—the sheep, the rooster, and the duck—have joined Benjamin Franklin and his kite in the folklore of our culture. Not so well known is the earlier history of ballooning; that the brothers Montgolfier had demonstrated their hot air balloons repeatedly for several months prior to the ascent over Paris; or that the physicist Charles, urged onward and financed by an enthusiast, Barthélemy Faujas de Saint-Fond, launched successfully the first fabric balloon filled with hydrogen over Paris more than 3 weeks prior to the memorable ascent of the sheep, and rooster, and the duck.For all of its well-documented detail, the book is readable and enjoyable. It is a well-written but complex book in which Professor Gillispie develops a number of subjects to recreate the era in perspective. The origins and the disposition of the Montgolfiers, the industry of the period, the idea of capturing heated air are all reported in detail. The attempts to obtain government funding and the promotional activities in Paris were forerunners of the modern techniques for obtaining support of research activities.

  3. A pedigree analysis of familial hypercholesterolemia in monozygote twin brothers.

    PubMed

    Li, Jian-Jun; Chen, Ming-Zhe; Chen, Xin

    2003-01-01

    The current study was designed to investigate the features of a family with familial hypercholesterolemia (FH). Twenty members of 3 generations in a family with hypercholesterolemia were enrolled in the study. The data collected were from clinical observation and subjected to pedigree analysis. The proband was a 41-year-old male who suffered from angina pectoris with multi-vessel stenosis of coronary arteries at the age of 40. Among 20 members, 8 individuals had FH in this family with a total incidence of 40% (54.5% [6/11] in male and 22.2% [2/9] in female). The serum total cholesterol level was increased in childhood from 7.1 to 10.8 mmol/L and tended to increase with increasing age. In addition, the level of total cholesterol was increased in monozygote twin brothers and their offspring in the family. This pedigree analysis showed that FH appears to be a hereditary disease of autosomal dominance, and attention should be paid, especially in the only son or daughter society of China.

  4. [Nutritional status of two generations of brothers and sisters <5 years of age beneficiaries from opportunities living in marginalized rural communities in Chiapas, Mexico].

    PubMed

    García-Parra, Esmeralda; Ochoa-Díaz-López, Héctor; García-Miranda, Rosario; Moreno-Altamirano, Laura; Morales, Helda; Estrada-Lugo, Erin Ingrid Jane; Solís-Hernández, Roberto

    2015-06-01

    En México, en las últimas décadas se han desarrollado varios programas para erradicar el problema de la desnutrición en infantes < de 5 años, principalmente de aquellos que viven en áreas indígenas y rurales. No obstante, no existe suficiente evidencia sobre su impacto en la salud y la nutrición infantil. Objetivo: describir los cambios nutricionales de dos generaciones de hermanos(as) que han sido beneficiados por el programa Oportunidades en comunidades rurales de Chiapas. Métodos: estudio transversal. Se determinó: bajo peso, baja talla, emaciación y SP + O (Sobrepeso más Obesidad). Los hermanos(as) mayores fueron evaluados en los años 2002-2003, para el 2010-2011 se evaluaron a los hermanos( as) menores, ambos grupos eran < de 5 años de edad en el momento de conseguir la información. Resultados: la desnutrición en sus tres formas es un problema, 43,4% de los hermanos(as) evaluados(as) en 2010-2011 presentaron baja talla, la prevalencia de bajo peso disminuyó de 18% a 13,2%, la emaciación (peso bajo para la talla) aumentó de 8,1% a 10.4%. El SP + O aumentó significativamente 12 puntos porcentuales entre los hermanos(as) de 24,8% en 2002-2003 a 36,8% en 2010-2011. La desnutrición en los niños (varones) es menor que la de sus hermanos de la generación de 2002- 2003 (baja talla p =.

  5. Brother-Sister Differences in the g Factor in Intelligence: Analysis of Full, Opposite-Sex Siblings from the NLSY1979

    ERIC Educational Resources Information Center

    Deary, Ian J.; Irwing, Paul; Der, Geoff; Bates, Timothy C.

    2007-01-01

    There is scientific and popular dispute about whether there are sex differences in cognitive abilities and whether they are relevant to the proportions of men and women who attain high-level achievements, such as Nobel Prizes. A recent meta-analysis (Lynn, R., and Irwing, P. (2004). Sex differences on the progressive matrices: a meta-analysis.…

  6. Do Brothers Affect Their Sisters' Chances to Graduate? An Analysis of Sibling Sex Composition Effects on Graduation from a University or a "Fachhochschule" in Germany

    ERIC Educational Resources Information Center

    Jacob, Marita

    2011-01-01

    In a recent paper on gender inequality in higher education Buchman and DiPrete (2006) assume that the decrease in the gender gap in college completion in the US can partly be explained by changes in the allocation of familial resources in favour of women. However, they do not test this hypothesis empirically. In this paper I examine the effects of…

  7. Brother is high Sr/Y two-mica granite and sister is leucogranite: twin granites in the Northern Himalayan Gneiss Domes, southern Tibet

    NASA Astrophysics Data System (ADS)

    Zeng, L.; Gao, L.; Xie, K.

    2011-12-01

    Leucogranites in the Himalayan orogen is widely considered as the type example of crustal melts, which provides a probe to investigate the interplay among high-grade metamorphism, crustal anatexis, and tectonic transition in large-scale collisional belts. Whether the leucogranite was a daughter product from a more primitive granitic melt is an interesting question that deserves careful examination to address the above issue. We report a new suite of two-mica granite (TMG) and leucogranite (LG) in the Yardoi gneiss dome (YGD) in the easternmost of the Northern Himalayan Gneiss Domes (NHGD), south of the Yarlung-Tsangpo suture. SHRIMP and LA-ICP-MS zircon U/Pb dating show that TMG and LG formed at ~17.7 Ma to ~20.0 Ma and at ~17.1 Ma, respectively. Both suites of granite have high Na/K (>1.30) ratios. The TMGs are characterized by (1) high Sr (>450 ppm), low Rb (<95 ppm) and Y (<6 ppm), and high Sr/Y (>86) ratios; (2) no Eu anomalies; and (3) low initial 87Sr/86Sr ratios (<0.7098) and higher ɛNd (>-8.5) values. In contrast, the LGs have (1) lower Sr (<130 ppm) and higher Rb (92-130 ppm); (2) pronounced negative Eu anomalies with Eu/Eu*<0.55; and (3) relatively higher Sr (87Sr/86Sr(t) =0.7136-0.7148) and unradiogenic Nd (ɛNd(t)=-7.7~-11.1). These data demonstrate that these Mid-Miocene granites have major and trace element and radiogenic isotope compositions similar to those of >35 Ma granites, but significantly different from those granites of similar ages in the High Himalaya as well as in the NHGD. High Sr/Y and relatively unradiogenic Sr isotope compositions in the TMGs could be derived from partial melting of mafic materials formed during previous compressional thickening event which was triggered by the input of juvenile heat and material associated with the Miocene E-W extension. An AFC process (plagioclase fractional crystallization and contamination by crustal materials) could be a primary factor leading to the formation of these LGs. Concurrence of high Sr/Y granites and leucogranites in NHGD indicates that the Miocene rifting could have played an important but previously unrecognized role in producing the Himalayan leucogranite. Similarly, the ~43-44 Ma high Sr/Y two-mica granites were also accompanied by the formation of typical leucogranite. However, the Mid-Eocene suite was derived from melting of lower crustal mafic materials at overthickened crustal conditions. Concurrence of high Sr/Y granites and typical leucogranites in the NHGD demonstrates that leucogranites could be derived from more primitive granitic melts by AFC process.

  8. Brother-Sister Differences in the g Factor in Intelligence: Analysis of Full, Opposite-Sex Siblings from the NLSY1979

    ERIC Educational Resources Information Center

    Deary, Ian J.; Irwing, Paul; Der, Geoff; Bates, Timothy C.

    2007-01-01

    There is scientific and popular dispute about whether there are sex differences in cognitive abilities and whether they are relevant to the proportions of men and women who attain high-level achievements, such as Nobel Prizes. A recent meta-analysis (Lynn, R., and Irwing, P. (2004). Sex differences on the progressive matrices: a meta-analysis.…

  9. Volcano hazards in the Three Sisters region, Oregon

    USGS Publications Warehouse

    Scott, William E.; Iverson, R.M.; Schilling, S.P.; Fisher, B.J.

    2001-01-01

    Three Sisters is one of three potentially active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. Two types of volcanoes exist in the Three Sisters region and each poses distinct hazards to people and property. South Sister, Middle Sister, and Broken Top, major composite volcanoes clustered near the center of the region, have erupted repeatedly over tens of thousands of years and may erupt explosively in the future. In contrast, mafic volcanoes, which range from small cinder cones to large shield volcanoes like North Sister and Belknap Crater, are typically short-lived (weeks to centuries) and erupt less explosively than do composite volcanoes. Hundreds of mafic volcanoes scattered through the Three Sisters region are part of a much longer zone along the High Cascades of Oregon in which birth of new mafic volcanoes is possible. This report describes the types of hazardous events that can occur in the Three Sisters region and the accompanying volcano-hazard-zonation map outlines areas that could be at risk from such events. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three Sisters and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three Sisters and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the

  10. Fulfilling the sisters' promise. The heritage of healthcare's early days.

    PubMed

    Friedman, E

    1997-01-01

    Members of religious orders--the sisters--built not just Catholic healthcare, but healthcare in America. A good 50 years before Henry and Edgar Kaiser got the idea, prepaid capitated health insurance was being offered by sisters who looked at what was needed and realized this was simply the best way to get it done. The sisters also created the integrated healthcare system at a time when the emerging medical elite wanted nothing to do with any patient who was not socially acceptable and potentially curable. They arranged a continuum of care for the aging sisters within their own communities. And they understood the concept of social medicine, of population-based healthcare, of healthy communities, long before these ideas became commonplace. But the sisters are gone, most of them. The question today is, How do we preserve the sisters' heritage and transfer it to a new millennium, a new healthcare system, and a new set of rules? First, it is important to understand that much of what we remember the sisters for--courage, compassion, vision-was not unique. They created many of the structures that today are the new models; but they were not alone. However, three aspects of how they expressed their vision and their faith were unique to the sisters and must be understood by those who wish to treat the path the sisters blazed. The purity of their commitment and its underlying philosophy--that the helpless and the sick must always be the point of the exercise--should pervade Catholic healthcare to its soul. These women, living in poverty, represented, and still represent, a singular group: a group of women who, having told the world that their only wish is to serve others, humble became CEOs of vast systems and trustees of huge enterprises, without ever abandoning that simple, original pledge. Although they bowed to the rule of obedience, and they were humble, the were fighters. They spoke out against poverty, bigotry, the shunning of those with certain diseases, lack of

  11. Protein requirements for sister telomere association in human cells

    PubMed Central

    Canudas, Silvia; Houghtaling, Benjamin R; Kim, Ju Youn; Dynek, Jasmin N; Chang, William G; Smith, Susan

    2007-01-01

    Previous studies in human cells indicate that sister telomeres have distinct requirements for their separation at mitosis. In cells depleted for tankyrase 1, a telomeric poly(ADP-ribose) polymerase, sister chromatid arms and centromeres separate normally, but telomeres remain associated and cells arrest in mitosis. Here, we use biochemical and genetic approaches to identify proteins that might mediate the persistent association at sister telomeres. We use immunoprecipitation analysis to show that the telomeric proteins, TRF1 (an acceptor of PARsylation by tankyrase 1) and TIN2 (a TRF1 binding partner) each bind to the SA1 ortholog of the cohesin Scc3 subunit. Sucrose gradient sedimentation shows that TRF1 cosediments with the SA1–cohesin complex. Depletion of the SA1 cohesin subunit or the telomeric proteins (TRF1 and TIN2) restores the normal resolution of sister telomeres in mitosis in tankyrase 1-depleted cells. Moreover, depletion of TRF1 and TIN2 or SA1 abrogates the requirement for tankyrase 1 in mitotic progression. Our studies indicate that sister telomere association in human cells is mediated by a novel association between a cohesin subunit and components of telomeric chromatin. PMID:17962804

  12. The template choice decision in meiosis: is the sister important?

    PubMed

    Pradillo, Mónica; Santos, Juan L

    2011-10-01

    Recombination between homologous chromosomes is crucial to ensure their proper segregation during meiosis. This is achieved by regulating the choice of recombination template. In mitotic cells, double-strand break repair with the sister chromatid appears to be preferred, whereas interhomolog recombination is favoured during meiosis. However, in the last year, several studies in yeast have shown the importance of the meiotic recombination between sister chromatids. Although this thinking seems to be new, evidences for sister chromatid exchange during meiosis were obtained more than 50 years ago in non-model organisms. In this mini-review, we comment briefly on the most recent advances in this hot topic and also describe observations which suggest the existence of inter-sister repair during meiotic recombination. For instance, the behaviour of mammalian XY bivalents and that of trivalents in heterozygotes for chromosomal rearrangements are cited as examples. The "rediscovering" of the requirement for the sister template, although it seems to occur at a low frequency, will probably prompt further investigations in organisms other than yeast to understand the complexity of the partner choice during meiosis.

  13. Teenage pregnancy: the impact of maternal adolescent childbearing and older sister's teenage pregnancy on a younger sister.

    PubMed

    Wall-Wieler, Elizabeth; Roos, Leslie L; Nickel, Nathan C

    2016-05-25

    Risk factors for teenage pregnancy are linked to many factors, including a family history of teenage pregnancy. This research examines whether a mother's teenage childbearing or an older sister's teenage pregnancy more strongly predicts teenage pregnancy. This study used linkable administrative databases housed at the Manitoba Centre for Health Policy (MCHP). The original cohort consisted of 17,115 women born in Manitoba between April 1, 1979 and March 31, 1994, who stayed in the province until at least their 20(th) birthday, had at least one older sister, and had no missing values on key variables. Propensity score matching (1:2) was used to create balanced cohorts for two conditional logistic regression models; one examining the impact of an older sister's teenage pregnancy and the other analyzing the effect of the mother's teenage childbearing. The adjusted odds of becoming pregnant between ages 14 and 19 for teens with at least one older sister having a teenage pregnancy were 3.38 (99 % CI 2.77-4.13) times higher than for women whose older sister(s) did not have a teenage pregnancy. Teenage daughters of mothers who had their first child before age 20 had 1.57 (99 % CI 1.30-1.89) times higher odds of pregnancy than those whose mothers had their first child after age 19. Educational achievement was adjusted for in a sub-population examining the odds of pregnancy between ages 16 and 19. After this adjustment, the odds of teenage pregnancy for teens with at least one older sister who had a teenage pregnancy were reduced to 2.48 (99 % CI 2.01-3.06) and the odds of pregnancy for teen daughters of teenage mothers were reduced to 1.39 (99 % CI 1.15-1.68). Although both were significant, the relationship between an older sister's teenage pregnancy and a younger sister's teenage pregnancy is much stronger than that between a mother's teenage childbearing and a younger daughter's teenage pregnancy. This study contributes to understanding of the broader topic "who is

  14. little sister: An Afro-Temporal Solo-Play.

    PubMed

    De Berry, Misty

    2016-09-12

    little sister: An Afro-Temporal Solo-Play is at once a memory-scape and a mytho-biography set to poetry, movement, and mixed media. A performance poem spanning from the Antebellum South to present-moment Chicago, it tells the story of a nomadic spirit named little-she who shape-shifts through the memories and imaginings of her sister, the narrator. Through the characters little-she and the narrator, the solo-performance explores embodied ways to rupture and relieve the impact of macro forms of violence in the micro realm of the everyday. To this end, little sister witnesses and disrupts the legacy of violence in the lives of queer Black women through a trans-temporal navigation of everyday encounters within familial, small groups and intimate partner spaces.

  15. Sister chromatid segregation in meiosis II: deprotection through phosphorylation.

    PubMed

    Wassmann, Katja

    2013-05-01

    Meiotic divisions (meiosis I and II) are specialized cell divisions to generate haploid gametes. The first meiotic division with the separation of chromosomes is named reductional division. The second division, which takes place immediately after meiosis I without intervening S-phase, is equational, with the separation of sister chromatids, similar to mitosis. This meiotic segregation pattern requires the two-step removal of the cohesin complex holding sister chromatids together: cohesin is removed from chromosome arms that have been subjected to homologous recombination in meiosis I and from the centromere region in meiosis II. Cohesin in the centromere region is protected from removal in meiosis I, but this protection has to be removed--deprotected--for sister chromatid segregation in meiosis II. Whereas the mechanisms of cohesin protection are quite well understood, the mechanisms of deprotection have been largely unknown until recently. In this review I summarize our current knowledge on cohesin deprotection.

  16. Familial acromegaly - case study of two sisters with acromegaly.

    PubMed

    Malicka, Joanna; Świrska, Joanna; Nowakowski, Andrzej

    2011-01-01

    In the majority of cases, acromegaly is sporadic. However, it can also occur in a familial setting as a component of MEN-1, MEN-4, Carney complex (CNC) or as the extremely rare syndrome of isolated familial somatotropinoma (IFS), the latter belonging to familial isolated pituitary adenomas (FIPA). The diagnosis of IFS is based on the recognition of acromegaly/gigantism in at least two family members, given that the family is not affected by MEN-1, MEN-4 or CNC. The authors present a case study of two sisters: a 56 year-old patient (case no. 1) and a 61 year-old patient (case no. 2). In both sisters, acromegaly was recognised in the course of pituitary macroadenoma. Neither of the sisters showed features of MEN-1, MEN-4 or Carney complex. The authors suppose that the presented cases are manifestations of IFS. However, this diagnosis has not been confirmed yet because of the poor availability of genetic tests.

  17. Brother of CDO (BOC) expression in equine articular cartilage.

    PubMed

    Vanderman, K S; Tremblay, M; Zhu, W; Shimojo, M; Mienaltowski, M J; Coleman, S J; MacLeod, J N

    2011-04-01

    Brother of CDO (BOC) is a cell surface receptor that derives its name from the structurally related protein, cell adhesion molecule-related/down-regulated by oncogenes (CDO, sometimes CDON). High levels of BOC mRNA and protein expression have been described in embryonic tissues with active cell proliferation and ongoing cellular differentiation(1,2). A microarray-based screen of RNA isolated from 11 different adult equine tissues unexpectedly identified BOC as having an expression pattern restricted to articular cartilage. The objective of this study was to further investigate BOC expression in adult articular cartilage relative to other tissues. Both RT-qPCR and mRNA sequencing confirmed the microarray data. Steady state BOC mRNA levels in articular cartilage were substantially higher than in the other adult tissues tested, neonatal tendon, placenta, and whole embryo. The expression of BOC displayed a pattern of tissue specificity comparable to well established cartilage matrix protein biomarkers. BOC mRNA levels in articular cartilage increased with age, but were rapidly down-regulated when chondrocytes were enzymatically isolated from the cartilage matrix and expanded in monolayer culture. Relative expression patterns of CDO were broadly similar, but displayed lower fold change differences. A functional role in articular cartilage that involves Hedgehog signaling is suggested by the known binding affinity of BOC for all three Hedgehog ligands. These data also extend BOC and CDO biology to a post-mitotic and highly differentiated cell type within a mature tissue. Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  18. Parallel phylogeographic structure in ecologically similar sympatric sister taxa.

    PubMed

    Dawson, Michael N

    2012-02-01

    Present-day phylogeographic patterns have been shaped by the dual histories of lineages and places, producing a diversity of relationships that may challenge discovery of general rules. For example, the predicted positive correlation between dispersal ability and gene flow has been supported inconsistently, suggesting unaccounted complexity in theory or the comparative framework. Here, I extend the sympatric sister-species approach, in which variance between lineages and places is minimized, to sister clades and test a fundamental assumption of comparative genetic studies of dispersal: that taxa which evolved at the same time and in the same place will, if they have similar life histories and ecologies, have essentially the same phylogeographic structure. Phylogenetic analyses of 197 Stigmatopora pipefishes using two nuclear (creatine kinase intron 6, α-tropomyosin) and two mitochondrial (16S, noncoding region) loci revealed largely synchronous parallel diversification of sister clades that are codistributed from Western Australia to New Zealand, supporting the null hypothesis. Only one comparison, however, yielded a sympatric sister-species pair (the two stem species), so I also explored the potential for extant species sharing a substantial proportion of their evolutionary histories in sympatry to substitute for sister taxon comparisons. In eastern Australia, where strong environmental structure is lacking, phylogeographic differences between species that have been codistributed for ~85% of their evolutionary histories were consistent with tendencies favoured by their modest life-history differences, that is the larger, rarer species had lower genetic diversity. In contrast, in New Zealand, two species codistributed for ~70% of their evolutionary histories were both structured similarly by a strong biogeographic filter despite differences in life history. Rigorously quantifying the influence of intrinsic and extrinsic factors on phylogeographic structure may

  19. Catholic sister nurses in Selma, Alabama, 1940-1972.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters' work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South.

  20. Japanese sisters with Pfeiffer syndrome and achondroplasia: a mutation analysis.

    PubMed

    Nagase, T; Nagase, M; Hirose, S; Ohmori, K

    1998-09-01

    The authors report the rare existence of a family that includes an older sister with Pfeiffer syndrome and a younger sister with achondroplasia. Gene analysis of these patients showed a T341P mutation in the FGFR2 gene in the patient with Pfeiffer syndrome, and a G380R mutation in the FGFR3 gene in the patient with achondroplasia. Both mutations have been reported previously. Their parents had no mutation in either locus. This result suggests the possibility that there may be predisposing factors for different FGFR mutations.

  1. The Essene's sister sect in Egypt: another medical site?

    PubMed

    Moss, G A

    2002-12-01

    The Essenes were, allegedly, the authors of the Dead Sea Scrolls and were settled by the Dead Sea. An ancient source locates their sister sect, The 'Therapeutae', as being by the shores of Lake Mareotis in Egypt. No scholar has previously sought to locate where exactly on Lake Mareotis they were settled. Using clues from Essene sites around the Dead Sea, an attempt is made to suggest a specific location for the Therapeutae. Since there are signs of medical activity at many of the Essene sites, a site with medical association is also sought for the location of the Essene's sister sect in Egypt. A suitable site is found at Canopus.

  2. Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.

    PubMed

    Blattner, Ariane C; Chaurasia, Soumya; McKee, Bruce D; Lehner, Christian F

    2016-04-01

    Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase.

  3. Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres

    PubMed Central

    Blattner, Ariane C.; McKee, Bruce D.; Lehner, Christian F.

    2016-01-01

    Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase. PMID:27120695

  4. Extreme right-handedness, older brothers, and sexual orientation in men.

    PubMed

    Bogaert, Anthony F

    2007-01-01

    Two of the most consistent correlates of sexual orientation in men are handedness and fraternal birth order (i.e., number of older brothers). In the present study, the relationship among handedness, older brothers, and sexual orientation was studied in 4 samples of heterosexual and gay or bisexual men (N = 944). Unlike previous studies, which have only observed an increased rate of non-right-handedness in gay or bisexual men relative to heterosexual men, an elevated rate of extreme right-handedness was found in gay or bisexual men relative to heterosexual men. The results also demonstrated that older brothers moderate the relationship between handedness and sexual orientation. Specifically, older brothers increase the odds of being gay or bisexual in moderate right-handers only; in both non-right-handers and extreme right-handers, older brothers do not affect (or decrease) the odds of being gay or bisexual. The results have implications for an early neurodevelopmental origin to sexual orientation in men. (c) 2007 APA, all rights reserved.

  5. Fragile X syndrome: Discordant levels of CGG repeat mosaicism in two brothers

    SciTech Connect

    Mueller, O.T.; Hartsfield, J.K. Jr.; Amar, M.J.A.

    1995-08-14

    Fragile X syndrome is associated with an unstable repeated CGG trinucleotide sequence in the 5{prime} untranslated region of the FMR-1 gene. A significant number of individuals with a mild or atypical presentation are mosaics for the CGG expansion. We report a family with two brothers. The proband had severe mental retardation as well as most of the Fragile X syndrome stigmata, whereas his brother shows only mild learning difficulties. Both inherited a 80 x CGG trinucleotide premutation from the mother. They were negative for the FRAXA fragile site in over 100 metaphases examined. Flanking markers verified that both had inherited the same FMR-1 allele and Xq27-q28 flanking sequences from the mother. The methylation status of the brothers indicated active FMR-1 transcription as determined by using StB12.3/EcoRI + Eagl blots. CGG size or methylation mosaicism was not apparent from Southern blots. Polymerase chain reaction and chemiluminescent detection identified that both brothers had different degrees of mosaicism for the CGG expansion. Large expansions amounting to 70% of the total were visible in the proband, whereas less than 5% of the signal was larger than the premutation in his mildly affected brother. These findings suggest that mosaicism may be responsible for some of the variation in penetrance in this disorder. 19 refs., 3 figs.

  6. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  7. Sister chromatid separation: falling apart at the seams.

    PubMed

    Cohen-Fix, O

    2000-11-16

    Cohesion between sister chromatids must be dissolved at the time of chromosome segregation. Recent studies reveal that the principles of cohesion dissolution in mitosis and meiosis are the same, but that there are important differences that stem from the distinct natures of these two processes.

  8. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... at the Marine Safety Center or in the files of the cognizant OCMI; (2) The owner of the plans... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100...

  9. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... vessel, provided: (1) Approved plans for the original vessel are on file at the Marine Safety Center or.... (b) If approved plans for original vessel are not on file at the Marine Safety Center (MSC) or with... 46 Shipping 4 2012-10-01 2012-10-01 false Plans for sister vessels. 116.210 Section...

  10. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... at the Marine Safety Center or in the files of the cognizant OCMI; (2) The owner of the plans... 46 Shipping 7 2014-10-01 2014-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100...

  11. Sister chromatid resolution: a cohesin releasing network and beyond.

    PubMed

    Shintomi, Keishi; Hirano, Tatsuya

    2010-10-01

    When chromosomes start to assemble in mitotic prophase, duplicated chromatids are not discernible within each chromosome. As condensation proceeds, they gradually show up, culminating in two rod-shaped structures apposed along their entire length within a metaphase chromosome. This process, known as sister chromatid resolution, is thought to be a prerequisite for rapid and synchronous separation of sister chromatids in anaphase. From a mechanistic point of view, the resolution process can be dissected into three distinct steps: (1) release of cohesin from chromosome arms; (2) formation of chromatid axes mediated by condensins; and (3) untanglement of inter-sister catenation catalyzed by topoisomerase II (topo II). In this review article, we summarize recent progress in our understanding the molecular mechanisms of sister chromatid resolution with a major focus on its first step, cohesin release. An emerging idea is that this seemingly simple step is regulated by an intricate network of positive and negative factors, including cohesin-binding proteins and mitotic kinases. Interestingly, some key factors responsible for cohesin release in early mitosis also play important roles in controlling cohesin functions during interphase. Finally, we discuss how the step of cohesin release might mechanistically be coordinated with the actions of condensins and topo II.

  12. Precocious Sister Chromatid Separation (PSCS) in Cornelia de Lange Syndrome

    PubMed Central

    Kaur, Maninder; DeScipio, Cheryl; McCallum, Jennifer; Yaeger, Dinah; Devoto, Marcella; Jackson, Laird G.; Spinner, Nancy B.; Krantz, Ian D.

    2009-01-01

    The Cornelia de Lange syndrome (CdLS) (OMIM# 122470) is a dominantly inherited multisystem developmental disorder. The phenotype consists of characteristic facial features, hirsutism, abnormalities of the upper extremities ranging from subtle changes in the phalanges and metacarpal bones to oligodactyly and phocomelia, gastroesophageal dysfunction, growth retardation, and neurodevelopmental delay. Prevalence is estimated to be as high as 1 in 10,000. Recently, mutations in NIPBL were identified in sporadic and familial CdLS cases. To date, mutations in this gene have been identified in over 45% of individuals with CdLS. NIPBL is the human homolog of the Drosophila Nipped-B gene. Although its function in mammalian systems has not yet been elucidated, sequence homologs of Nipped-B in yeast (Scc2 and Mis4) are required for sister chromatid cohesion during mitosis, and a similar role was recently demonstrated for Nipped-B in Drosophila. In order to evaluate NIPBL role in sister chromatid cohesion in humans, metaphase spreads on 90 probands (40 NIPBL mutation positive and 50 NIPBL mutation negative) with CdLS were evaluated for evidence of precocious sister chromatid separation (PSCS). We screened 50 metaphases from each proband and found evidence of PSCS in 41% (compared to 9% in control samples). These studies indicate that NIPBL may play a role in sister chromatid cohesion in humans as has been reported for its homologs in Drosophila and yeast. PMID:16100726

  13. Letters from a suicide: Van Gogh and his sister.

    PubMed

    Lester, David

    2010-04-01

    An analysis of trends over a 3-yr. period in the letters of Vincent Van Gogh to his sister as the time of his suicide approached identified 8 trends, including an increase in words concerned with anxiety and words concerned with the past.

  14. Analysis of meiotic sister chromatid cohesion in Caenorhabditis elegans

    PubMed Central

    Severson, Aaron F.

    2016-01-01

    In sexually reproducing organisms, the formation of healthy gametes (sperm and eggs) requires the proper establishment and release of meiotic sister chromatid cohesion (SCC). SCC tethers replicated sisters from their formation in premeiotic S phase until the stepwise removal of cohesion in anaphase of meiosis I and II allows the separation of homologs and then sisters. Defects in the establishment or release of meiotic cohesion cause chromosome segregation errors that lead to the formation of aneuploid gametes and inviable embryos. The nematode Caenorhabditis elegans is an excellent model for studies of meiotic sister chromatid cohesion due to its genetic tractability and the excellent cytological properties of the hermaphrodite gonad. Moreover, mutants defective in the establishment or maintenance of meiotic SCC nevertheless produce abundant gametes, allowing analysis of the pattern of chromosome segregation. Here I will describe two approaches for analysis of meiotic cohesion in C. elegans. The first approach relies on cytology to detect and quantify defects in SCC. The second approach relies on PCR and restriction digests to identify embryos that inherited an incorrect complement of chromosomes due to aberrant meiotic chromosome segregation. Both approaches are sensitive enough to identify rare errors and precise enough to reveal distinctive phenotypes resulting from mutations that perturb meiotic SCC in different ways. The robust, quantitative nature of these assays should strengthen phenotypic comparisons of different meiotic mutants and enhance the reproducibility of data generated by different investigators. PMID:27797074

  15. The Racial Integration of the Seven Sister Colleges.

    ERIC Educational Resources Information Center

    Perkins, Linda M.

    1998-01-01

    Although the number of African-American women who attended the elite Seven Sisters colleges prior to 1900 was small, these women were highly influential. Early integration is discussed for: (1) Wellesley College; (2) Radcliffe College; (3) Smith College; (4) Mount Holyoke College; (5) Bryn Mawr College; (6) Vassar College; and (7) Barnard College.…

  16. Sister Mary Joseph's nodule that originated from lung adenocarcinoma.

    PubMed

    Haruki, Tomohiro; Nakamura, Hiroshige; Kubouchi, Yasuaki; Taniguchi, Yuji; Miwa, Ken; Adachi, Yoshin; Fujioka, Shinji; Ito, Hisao

    2011-03-01

    Umbilical metastasis of cancer, known as Sister Mary Joseph's nodule (SMJN), is a rare phenomenon. It is usually due to intraabdominal malignancies and is quite rare from lung cancer. Here we describe a case of SMJN that originated from advanced lung adenocarcinoma. SMJN should be noted as an important sign of some hidden malignancy including lung cancer.

  17. Hearing My Mother's Voice: A Study of Sisters and Mothers.

    ERIC Educational Resources Information Center

    Morris, Beverley

    There seems to be an assumption among many people that parents can mold the later adult personality of their offspring by manipulating their childhood upbringing. To tease out the variables in childrearing and to discover some of the sources of the childbearing practices of mothers in the 1980s, a study of sisters and their mothers (N=48) in the…

  18. Comparing breast cancer risk between lesbians and their heterosexual sisters.

    PubMed

    Dibble, Suzanne L; Roberts, Stephanie A; Nussey, Brenda

    2004-01-01

    The purpose of this study was to explore the similarities and differences between lesbians and their heterosexual sisters in the established risks for developing breast cancer. The design for this study was a matched (lesbian with heterosexual sister) cross-sectional, mail-back, anonymous survey. We distributed the surveys throughout the state of California to English-speaking women who identified themselves as lesbians, age 40 and older, and their sisters. Using the modified Gail Breast Cancer Risk model as well as other well-established factors associated with the development of breast cancer, we compared the breast cancer risk potential for 324 sister pairs (N = 648). Data were analyzed using paired t-tests, analysis of covariance (ANCOVA), McNemar's chi(2), or the Bowker statistic, as appropriate for the level of data. The lesbians had significantly higher 5-year (p <.0001) and lifetime (p =.001) risk for developing breast cancer. The reasons for lesbians' predicted rate of breast cancer were most likely their higher scores on all pregnancy-related variables and the relatively high number of breast biopsies they reported. The lesbians had used birth control pills less (p <. 0001), had significantly fewer pregnancies (p <.0001), children (p <.0001), abortions (p <.0001), and miscarriages (p <.0001) as well as significantly more breast biopsies (p =.02) than did their heterosexual sisters. A lesbian who comes out to her clinician is relying on the clinician to be informed and be open to discuss her life. When a lesbian has a lump or a suspicious mammogram, she needs her clinician to advocate for her within the health care system because she is at higher risk for having cancer than a heterosexual woman.

  19. Constructing and enacting kinship in sister-to-sister egg donation families: a multi-family member interview study.

    PubMed

    Van Parys, Hanna; Provoost, Veerle; Zeiler, Kristin; De Sutter, Petra; Pennings, Guido; Buysse, Ann

    2016-12-05

    Although intra-familial egg donation has been practiced for more than 15 years in several countries, little is known about family relationships in this family type. Framed within the new kinship studies, this article focuses on the experiential dimension of kinship in sister-to-sister egg donation families: how is kinship 'unpacked' and 'reconstructed' in this specific family constellation? Qualitative data analysis of interviews with receiving parents, their donating sisters and the donor children revealed six themes: (1) being connected as an extended family; (2) disambiguating motherhood; (3) giving and receiving as structuring processes; (4) acknowledging and managing the 'special' link between donor and child; (5) making sense of the union between father and donor; and (6) kinship constructions being challenged. This study showed the complex and continuous balancing of meanings related to the mother-child dyad, the donor-child dyad and the donor-father dyad. What stood out was the complexity of, on the one hand cherishing the genetic link with the child allowed by the sisters' egg donation, while, on the other, managing the meanings related to this link, by, for instance, acknowledging, downsizing, symbolising, and differentiating it from the mother-child bond. (A Virtual Abstract of this paper can be accessed at: https://www.youtube.com/channel/UC_979cmCmR9rLrKuD7z0ycA).

  20. Microcephaly-capillary malformation syndrome: Brothers with a homozygous STAMBP mutation, uncovered by exome sequencing.

    PubMed

    Naseer, Muhammad Imran; Sogaty, Sameera; Rasool, Mahmood; Chaudhary, Adeel G; Abutalib, Yousif Ahmed; Walker, Susan; Marshall, Christian R; Merico, Daniele; Carter, Melissa T; Scherer, Stephen W; Al-Qahtani, Mohammad H; Zarrei, Mehdi

    2016-11-01

    We describe two brothers from a consanguineous family of Egyptian ancestry, presenting with microcephaly, apparent global developmental delay, seizures, spasticity, congenital blindness, and multiple cutaneous capillary malformations. Through exome sequencing, we uncovered a homozygous missense variant in STAMBP (p.K303R) in the two siblings, inherited from heterozygous carrier parents. Mutations in STAMBP are known to cause microcephaly-capillary malformation syndrome (MIC-CAP) and the phenotype in this family is consistent with this diagnosis. We compared the findings in the present brothers with those of earlier reported patients. © 2016 Wiley Periodicals, Inc.

  1. Dual of big bang and big crunch

    SciTech Connect

    Bak, Dongsu

    2007-01-15

    Starting from the Janus solution and its gauge theory dual, we obtain the dual gauge theory description of the cosmological solution by the procedure of double analytic continuation. The coupling is driven either to zero or to infinity at the big-bang and big-crunch singularities, which are shown to be related by the S-duality symmetry. In the dual Yang-Mills theory description, these are nonsingular as the coupling goes to zero in the N=4 super Yang-Mills theory. The cosmological singularities simply signal the failure of the supergravity description of the full type IIB superstring theory.

  2. The big deal about big data.

    PubMed

    Moore, Keith D; Eyestone, Katherine; Coddington, Dean C

    2013-08-01

    Big data is a concept that is being widely applied in the retail industries as a means to understand customers' purchasing habits and preferences for followup promotional activity. It is characterized by vast amounts of diverse and rapidly multiplying data that are available at or near real-time. Conversations with executives of leading healthcare organizations provide a barometer for understanding where the industry stands in its adoption of big data as a means to meet the critical information requirements of value-based health care.

  3. Restoring Wyoming big sagebrush

    Treesearch

    Cindy R. Lysne

    2005-01-01

    The widespread occurrence of big sagebrush can be attributed to many adaptive features. Big sagebrush plays an essential role in its communities by providing wildlife habitat, modifying local environmental conditions, and facilitating the reestablishment of native herbs. Currently, however, many sagebrush steppe communities are highly fragmented. As a result, restoring...

  4. ARTIST CONCEPT - BIG JOE

    NASA Image and Video Library

    1963-09-01

    S63-19317 (October 1963) --- Pen and ink views of comparative arrangements of several capsules including the existing "Big Joe" design, the compromise "Big Joe" design, and the "Little Joe". All capsule designs are labeled and include dimensions. Photo credit: NASA

  5. Implementing Big History.

    ERIC Educational Resources Information Center

    Welter, Mark

    2000-01-01

    Contends that world history should be taught as "Big History," a view that includes all space and time beginning with the Big Bang. Discusses five "Cardinal Questions" that serve as a course structure and address the following concepts: perspectives, diversity, change and continuity, interdependence, and causes. (CMK)

  6. Implementing Big History.

    ERIC Educational Resources Information Center

    Welter, Mark

    2000-01-01

    Contends that world history should be taught as "Big History," a view that includes all space and time beginning with the Big Bang. Discusses five "Cardinal Questions" that serve as a course structure and address the following concepts: perspectives, diversity, change and continuity, interdependence, and causes. (CMK)

  7. 77 FR 46439 - Decision To Evaluate a Petition To Designate a Class of Employees From the Baker Brothers Site in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... HUMAN SERVICES Decision To Evaluate a Petition To Designate a Class of Employees From the Baker Brothers Site in Toledo, Ohio, To Be Included in the Special Exposure Cohort AGENCY: National Institute for... to evaluate a petition to designate a class of employees from the Bakers Brothers site in...

  8. "Our Boys": The Christian Brothers and the Formation of Youth in the "New Ireland"1914-1944

    ERIC Educational Resources Information Center

    Keogh, Daire

    2015-01-01

    This essay investigates the development of the boys' magazine, "Our Boys," and how this became a powerful auxiliary to the Christian Brothers' work in schools. It championed the values that the Christian Brothers had propagated since their foundation in 1802. Often characterised as Celtic and Romantic, it was neither, but aimed at…

  9. "Our Boys": The Christian Brothers and the Formation of Youth in the "New Ireland"1914-1944

    ERIC Educational Resources Information Center

    Keogh, Daire

    2015-01-01

    This essay investigates the development of the boys' magazine, "Our Boys," and how this became a powerful auxiliary to the Christian Brothers' work in schools. It championed the values that the Christian Brothers had propagated since their foundation in 1802. Often characterised as Celtic and Romantic, it was neither, but aimed at…

  10. Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors

    PubMed Central

    Killoren, Sarah E.; Roach, Andrea L.

    2013-01-01

    Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls’ ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters’ similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843

  11. Big data for health.

    PubMed

    Andreu-Perez, Javier; Poon, Carmen C Y; Merrifield, Robert D; Wong, Stephen T C; Yang, Guang-Zhong

    2015-07-01

    This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of big data and how medical and health informatics, translational bioinformatics, sensor informatics, and imaging informatics will benefit from an integrated approach of piecing together different aspects of personalized information from a diverse range of data sources, both structured and unstructured, covering genomics, proteomics, metabolomics, as well as imaging, clinical diagnosis, and long-term continuous physiological sensing of an individual. It is expected that recent advances in big data will expand our knowledge for testing new hypotheses about disease management from diagnosis to prevention to personalized treatment. The rise of big data, however, also raises challenges in terms of privacy, security, data ownership, data stewardship, and governance. This paper discusses some of the existing activities and future opportunities related to big data for health, outlining some of the key underlying issues that need to be tackled.

  12. Geologic map of Three Sisters volcanic cluster, Cascade Range, Oregon

    USGS Publications Warehouse

    Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.

    2012-01-01

    The cluster of glaciated stratovolcanoes called the Three Sisters—South Sister, Middle Sister, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North Sister (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle Sister (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South Sister is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South Sister, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist

  13. Severe complications in wound healing and fracture treatment in two brothers with congenital insensitivity to pain with anhidrosis.

    PubMed

    Rapp, Marion; Spiegler, Juliane; Härtel, Christoph; Gillessen-Kaesbach, Gabrielle; Kaiser, Martin M

    2013-01-01

    Congenital insensitivity to pain with anhidrosis is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene, which encodes the receptor for nerve growth factor. We report the clinical and radiological pitfalls in the diagnosis and treatment of two brothers, aged 5 and 8 years, with congenital insensitivity to pain with anhidrosis, the older brother having a proven NTRK1 mutation. In the neonatal period, both presented with recurrent episodes of fever of unknown origin, but their clinical problems changed later. In addition to severe mental retardation and self-harming behaviour, the older brother developed recurrent nonbacterial destructive infections of both the calcaneus and later the talus. No immunodeficiency was found. The younger brother had three complex fractures with a long history of healing problems: overwhelming production of callus, osteomyelitis and movement restrictions. He has less mental retardation than his older brother and shows no self-mutilation.

  14. Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

    PubMed Central

    Tse, Karen; Grant, Claire; Keerie, Amy; Simpson, David J.; Pedersen, John C.; Rimmer, Victoria; Leslie, Lauren; Klein, Stephanie K.; Karp, Natasha A.; Sillito, Rowland; Chartsias, Agis; Lukins, Tim; Heward, James; Vickers, Catherine; Chapman, Kathryn; Armstrong, J. Douglas

    2017-01-01

    Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFID) transponder to measure ambulatory activity and temperature of individual rats when group-housed in conventional, rack-mounted home cages. The transponder location and temperature is detected by a matrix of antennae in a baseplate under the cage. An infrared high-definition camera acquires side-view video of the cage and also enables automated detection of vertical activity. Validation studies showed that baseplate-derived ambulatory activity correlated well with manual tracking and with side-view whole-cage video pixel movement. This technology enables individual behavioral and temperature data to be acquired continuously from group-housed rats in their familiar, home cage environment. We demonstrate its ability to reliably detect naturally occurring behavioral effects, extending beyond the capabilities of routine observational tests and conventional monitoring equipment. It has numerous potential applications including safety pharmacology, toxicology, circadian biology, disease models and drug discovery. PMID:28877172

  15. Socio-Technical Systems Analysis and Manufacturing Technology: Addressing "Big Brother" and Computers in Blue-Collar Work.

    ERIC Educational Resources Information Center

    Taylor, James C.

    For more than 80 years, jobs in the United States have been designed by people for others. For most of these years, the experts in job design have placed the production technology above the job holder in importance. Since the 1950s, many jobs have been redesigned around new, computer-based technology. Often, the net effect has been to make those…

  16. Is Big Brother Watching You? The Evolving Role of the State in Regulating and Conducting Quality Assurance. CIQG Publication Series

    ERIC Educational Resources Information Center

    Salmi, Jamil

    2015-01-01

    A recent report published in the United Kingdom proposed the image of "an avalanche" to describe the radical changes affecting tertiary education in many parts of the world (Barber, Donnelly and Rizvi, 2013). Indeed, powerful transformative forces of three kinds--rupture factors, crisis factors and stimulus factors--are challenging…

  17. Socio-Technical Systems Analysis and Manufacturing Technology: Addressing "Big Brother" and Computers in Blue-Collar Work.

    ERIC Educational Resources Information Center

    Taylor, James C.

    For more than 80 years, jobs in the United States have been designed by people for others. For most of these years, the experts in job design have placed the production technology above the job holder in importance. Since the 1950s, many jobs have been redesigned around new, computer-based technology. Often, the net effect has been to make those…

  18. Big data, big knowledge: big data for personalized healthcare.

    PubMed

    Viceconti, Marco; Hunter, Peter; Hose, Rod

    2015-07-01

    The idea that the purely phenomenological knowledge that we can extract by analyzing large amounts of data can be useful in healthcare seems to contradict the desire of VPH researchers to build detailed mechanistic models for individual patients. But in practice no model is ever entirely phenomenological or entirely mechanistic. We propose in this position paper that big data analytics can be successfully combined with VPH technologies to produce robust and effective in silico medicine solutions. In order to do this, big data technologies must be further developed to cope with some specific requirements that emerge from this application. Such requirements are: working with sensitive data; analytics of complex and heterogeneous data spaces, including nontextual information; distributed data management under security and performance constraints; specialized analytics to integrate bioinformatics and systems biology information with clinical observations at tissue, organ and organisms scales; and specialized analytics to define the "physiological envelope" during the daily life of each patient. These domain-specific requirements suggest a need for targeted funding, in which big data technologies for in silico medicine becomes the research priority.

  19. Big Data in industry

    NASA Astrophysics Data System (ADS)

    Latinović, T. S.; Preradović, D. M.; Barz, C. R.; Latinović, M. T.; Petrica, P. P.; Pop-Vadean, A.

    2016-08-01

    The amount of data at the global level has grown exponentially. Along with this phenomena, we have a need for a new unit of measure like exabyte, zettabyte, and yottabyte as the last unit measures the amount of data. The growth of data gives a situation where the classic systems for the collection, storage, processing, and visualization of data losing the battle with a large amount, speed, and variety of data that is generated continuously. Many of data that is created by the Internet of Things, IoT (cameras, satellites, cars, GPS navigation, etc.). It is our challenge to come up with new technologies and tools for the management and exploitation of these large amounts of data. Big Data is a hot topic in recent years in IT circles. However, Big Data is recognized in the business world, and increasingly in the public administration. This paper proposes an ontology of big data analytics and examines how to enhance business intelligence through big data analytics as a service by presenting a big data analytics services-oriented architecture. This paper also discusses the interrelationship between business intelligence and big data analytics. The proposed approach in this paper might facilitate the research and development of business analytics, big data analytics, and business intelligence as well as intelligent agents.

  20. BigDog

    NASA Astrophysics Data System (ADS)

    Playter, R.; Buehler, M.; Raibert, M.

    2006-05-01

    BigDog's goal is to be the world's most advanced quadruped robot for outdoor applications. BigDog is aimed at the mission of a mechanical mule - a category with few competitors to date: power autonomous quadrupeds capable of carrying significant payloads, operating outdoors, with static and dynamic mobility, and fully integrated sensing. BigDog is about 1 m tall, 1 m long and 0.3 m wide, and weighs about 90 kg. BigDog has demonstrated walking and trotting gaits, as well as standing up and sitting down. Since its creation in the fall of 2004, BigDog has logged tens of hours of walking, climbing and running time. It has walked up and down 25 & 35 degree inclines and trotted at speeds up to 1.8 m/s. BigDog has walked at 0.7 m/s over loose rock beds and carried over 50 kg of payload. We are currently working to expand BigDog's rough terrain mobility through the creation of robust locomotion strategies and terrain sensing capabilities.

  1. Chromosome and sister chromatid exchange studies in Behcet's patients.

    PubMed

    Oztas, Sitki; Gullulu, Gulay; Tatar, Abdulgani; Astam, Neslihan; Akyol, Ilknur; Karakuzu, Ali; Aktas, Akin; Odabas, Ali Riza

    2006-06-01

    Behcet's disease is a chronic multisystemic disease of unknown pathogenesis characterized by four major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. The disease is spread throughout the world, but it is most frequent in Turkey, Japan, Korea and China. Although HLA-Bw51 has been found to predominate in Behcet's cases, the genetic etiology has not yet been clarified. In this study, we investigated the chromosomal abnormalities and sister chromatid exchange rates in patients with Behcet's diseases. Thirty-eight patients with Behcet's disease (diagnosed for the first time) and 30 healthy subjects (as controls) were included in this study. Although numerical and structural chromosomal abnormalities were not detected in our patients, we found an increased rate of sister chromatid exchange in patients over the control groups (P < 0.01). On the basis of these results, we discuss the genetic etiology of Behcet's disease.

  2. Idiopathic Steatorrhea Presenting with Different Manifestations in Sisters

    PubMed Central

    Rally, C. R.; Munroe, D. S.; Bogoch, A.

    1964-01-01

    Although it is well known that the incidence of idiopathic steatorrhea is much higher in relatives of patients with this disease than it is in the general population, there has been little comment on the variability of symptoms in familial cases. Two sisters with this disease are reported. One presented with a relatively acute history of diarrhea, weight loss, fatigue and peripheral edema and was found to have a normal hemoglobin, hypocalcemia and a markedly decreased prothrombin activity. Her elder sister tended to constipation and had a 10-year history of refractory iron-deficiency anemia. The diagnosis was confirmed in both by peroral jejunal biopsy. ImagesFig. 1Fig. 2 PMID:14122463

  3. Umbilical metastasis (Sister Joseph's nodule) from carcinoma of the vagina.

    PubMed

    Bakri, Y N; Subhi, J; Hashim, E; Senoussi, M

    1991-01-01

    A case is reported of a squamous cell carcinoma of the vagina with metastasis to the umbilicus (Sister Mary Joseph's nodule). Systemic cisplatinum chemotherapy resulted in partial response, however, the "nodule" was a sign of poor prognosis and indicative of short-term survival. To the best of our knowledge, this is the first report of umbilical metastasis from a primary carcinoma of the vagina.

  4. Evidence of environmental suppression of familial resemblance: height among US Civil War brothers.

    PubMed

    Lauderdale, D S; Rathouz, P J

    1999-01-01

    This study examines, with historical data, whether within family correlations in height varied across environments and whether variability in height was greater in worse environments. To investigate these hypotheses, brothers were identified who were mustered into the Union Army of the US Civil War, using linked records from the 1850 and 1860 censuses and military and medical records. Heights were available for 3898 men aged 18 and older, of whom 595 were further identified as belonging to 288 family sets of two, three or four brothers. Generalized estimating equations were used to concurrently model the mean height, the variance and the correlation between brothers as a function of county population. Heights decreased as county population size increased (p<0.001). The correlation between brothers' heights decreased significantly (p = 0.032) with increasing county population, and the variance increased (p = 0.026). The correlation ranged approximately from 0.63 in the least populous to 0.24 in the most populous counties. The degree of familial resemblance was lower in environments where mean height was lower, and the variability in height was greater, suggesting that the environmental contribution to the variability in height is of greater relative importance in populations reared, on average, in worse environments.

  5. Brief Report: Comparative ABA and DIR Trials in Twin Brothers with Autism

    ERIC Educational Resources Information Center

    Hilton, Jane C.; Seal, Brenda C.

    2007-01-01

    Trial interventions in DIR and ABA with twin brothers with autism were offered to help the parents choose one of the programs for their sons. Pre- and post-test scores on the Communication and Symbolic Behavior Scales (CSBS) revealed a slight gain in the composite score of the ABA child and a slight loss in the score of the DIR child. Contrasted…

  6. Two Brothers, Two Cities: Music Education in Boston and Cincinnati from 1830-1844

    ERIC Educational Resources Information Center

    Lenzo, Terri Brown; Resta, Craig

    2011-01-01

    The birth of American music education is often attributed solely to Lowell Mason in Boston. His younger brother Timothy, however, was also active at the same time in Cincinnati. This study traces the roots of music education in both cities, but highlights the rarely cited accomplishments of Timothy Mason and his colleagues. Using historical…

  7. Two Brothers, Two Cities: Music Education in Boston and Cincinnati from 1830-1844

    ERIC Educational Resources Information Center

    Lenzo, Terri Brown; Resta, Craig

    2011-01-01

    The birth of American music education is often attributed solely to Lowell Mason in Boston. His younger brother Timothy, however, was also active at the same time in Cincinnati. This study traces the roots of music education in both cities, but highlights the rarely cited accomplishments of Timothy Mason and his colleagues. Using historical…

  8. When Your "Problem" Becomes Mine: Adult Female Siblings' Perspectives of Having a Brother with a Disability

    ERIC Educational Resources Information Center

    Pompeo, Michelle N.

    2009-01-01

    This study is a retrospective look at adult female siblings' perspectives of their childhoods and present identities based on having a brother with a disability. This paper focuses on siblings' experiences within educational and public domains, and how such experiences have shaped their personalities and career choices. Qualitative findings were…

  9. The Wright Brothers and the Future of Bio-Inspired Flight: 1899 through to the Future

    NASA Technical Reports Server (NTRS)

    Bowers, Albion

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that proceeded the first powered flight.

  10. Burden of Common Complex Disease Variants in the Exomes of Two Healthy Centenarian Brothers.

    PubMed

    Tindale, Lauren C; Zeng, Andy; Bretherick, Karla L; Leach, Stephen; Thiessen, Nina; Brooks-Wilson, Angela R

    2015-01-01

    It is not understood whether long-term good health is promoted by the absence of disease risk variants, the presence of protective variants, or both. We characterized the exomes of two exceptionally healthy centenarian brothers aged 106 and 109 years who had never been diagnosed with cancer, cardiovascular disease, diabetes, Alzheimer's disease, or major pulmonary disease. The aim of this study was to gain insight into whether exceptional health and longevity are a result of carrying fewer disease-associated variants than typical individuals. We compared the number of disease-associated alleles, and the proportion of alleles predicted to be functionally damaging, between the centenarian brothers and published population data. Mitochondrial sequence reads were extracted from the exome data in order to analyze mitochondrial variants. The brothers carry a similar number of common disease-associated variants and predicted damaging variants compared to reference groups. They did not carry any high-penetrance clinically actionable variants. They carry mitochondrial haplogroup T, and one brother has a single heteroplasmic variant. Although our small sample size does not allow for definitive conclusions, a healthy aging and longevity phenotype is not necessarily due to a decreased burden of common disease-associated variants. Instead, it may be rare 'positive' variants that play a role in this desirable phenotype. © 2015 S. Karger AG, Basel.

  11. Brothers in Excellence: An Empowerment Model for the Career Development of African American Boys

    ERIC Educational Resources Information Center

    Grimmett, Marc A.

    2010-01-01

    The author describes Brothers in Excellence (BE), a conceptual model for understanding African American boys and helping them to be successful. BE addresses 3 domains of development proposed to be essential to the success of all African American boys: identity development, social development, and career development. (Contains 1 figure.)

  12. A Thousand Lights [and] A Thousand Lights: Teacher and Parent Guide. Brothers Series.

    ERIC Educational Resources Information Center

    Benton, Hope

    This book for children (ages 8 to 14) and the accompanying teacher/parent guide present the story of two brothers, one of whom has a severe hearing impairment, who climb up Mt. Fuji in Japan. Information on the disability is presented subtly and incidentally to encourage the reader to relate more personally and foster a deeper level of acceptance…

  13. A Thousand Lights [and] A Thousand Lights: Teacher and Parent Guide. Brothers Series.

    ERIC Educational Resources Information Center

    Benton, Hope

    This book for children (ages 8 to 14) and the accompanying teacher/parent guide present the story of two brothers, one of whom has a severe hearing impairment, who climb up Mt. Fuji in Japan. Information on the disability is presented subtly and incidentally to encourage the reader to relate more personally and foster a deeper level of acceptance…

  14. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  15. Sibling Communication in "Star Trek: The Next Generation": Conflicts between Brothers.

    ERIC Educational Resources Information Center

    Fuss-Reineck, Marilyn

    "Star Trek: The Next Generation" depicts sibling relationships between Data and Lore (android), Worf and Kurn (Klingon) and Jean-Luc and Robert (human) that illustrate conflictual communication and suggest teaching applications. The most disturbing empirical communication research on conflict between brothers reports that male sibling…

  16. The Liability of Having Brothers: Paying for College and the Sex Composition of the Family.

    ERIC Educational Resources Information Center

    Powell, Brian; Steelman, Lala Carr

    1989-01-01

    Examines effects that the sex composition of family has upon ways in which families finance higher education. Finds that as the number of brothers increases, the likelihood that a student will meet his financial obligation through means other than parental contribution becomes greater. Suggests sex composition is a structural element of the…

  17. Circuits of Spectacle: The Miller Brothers' 101 Ranch Real Wild West

    ERIC Educational Resources Information Center

    Fields, Alison

    2012-01-01

    The Miller Brothers' 101 Ranch Real Wild West show ran from 1906 to 1931, outlasting the famous Buffalo Bill's Wild West show by more than a decade. From its beginnings in Oklahoma Territory, the Real Wild West show traveled national and international circuits and built a broad roster of performers, including more than 150 American Indians. During…

  18. Another Look at Vividness in the Trial of Two Vietnamese Brothers.

    ERIC Educational Resources Information Center

    Bresnahan, Mary I.

    A study examined the trial of People v. Tien (two Vietnamese brothers named defendants in an assault case). In order to understand better the relationship between supportive speech acts and credibility, the study examined how the attorney elicited vivid testimony. One of the ways in which an attorney yields control of testimony to a witness is by…

  19. The Irish Christian Brothers and the National Board of Education: Challenging the Myths

    ERIC Educational Resources Information Center

    McLaughlin, Denis

    2008-01-01

    For close to 170 years the general consensus from historians has been that Edmund Rice, who founded the Irish Christian Brothers in 1802, was an unenthusiastic applicant to the National Board of Education in Ireland in 1832 and later withdrew his schools because he believed his education was incompatible with the philosophy underpinning the…

  20. The Role of Digital Literacy Practices on Refugee Resettlement: The Case of Three Karen Brothers

    ERIC Educational Resources Information Center

    Gilhooly, Daniel; Lee, Eunbae

    2014-01-01

    This study explores the social and cultural uses of digital literacies by adolescent immigrants to cope with their new lives in the United States. This case study focuses on three adolescent ethnic Karen brothers. Two years of participant observations in their home and Karen community, accompanied by formal and informal interviews, served as the…

  1. 3 CFR 8918 - Proclamation 8918 of December 17, 2012. Wright Brothers Day, 2012

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... December 17, 2012 Proc. 8918 Wright Brothers Day, 2012By the President of the United States of America A... example inspired the kind of businesses and industries that built and grew our middle class. As we mark... requested the President to issue annually a proclamation inviting the people of the United States to...

  2. Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma.

    PubMed

    Ji, Jianling; Quindipan, Catherine; Parham, David; Shen, Lishuang; Ruble, David; Bootwalla, Moiz; Maglinte, Dennis T; Gai, Xiaowu; Saitta, Sulagna C; Biegel, Jaclyn A; Mascarenhas, Leo

    2017-05-01

    We report a family in which two brothers had an undiagnosed genetic disorder comprised of dysmorphic features, microcephaly, severe intellectual disability (non-verbal), mild anemia, and cryptorchidism. Both developed osteosarcoma. Trio exome sequencing (using blood samples from the younger brother and both parents) was performed and a nonsense NM_000489.4:c.7156C>T (p.Arg2386*) mutation in the ATRX gene was identified in the proband (hemizygous) and in the mother's peripheral blood DNA (heterozygous). The mother is healthy, does not exhibit any clinical manifestations of ATR-X syndrome and there was no family history of cancer. The same hemizygous pathogenic variant was confirmed in the affected older brother's skin tissue by subsequent Sanger sequencing. Chromosomal microarray studies of both brothers' osteosarcomas revealed complex copy number alterations consistent with the clinical diagnosis of osteosarcoma. Recently, somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome. This is the first report of osteosarcoma diagnosed in two males with ATR-X syndrome, suggesting a potential increased risk for cancer in patients with this disorder. © 2017 Wiley Periodicals, Inc.

  3. My Brother as "Problem": Neoliberal Governmentality and Interventions for Black Young Men and Boys

    ERIC Educational Resources Information Center

    Dumas, Michael J.

    2016-01-01

    In this article, the author argues that the Obama Administration's My Brother's Keeper (MBK) initiative serves as an exemplar of neoliberal governmentality, in which Black young men and boys are constructed as essentially damaged, as problems in need of a technocratic public--private solution. More than simply an ideological imposition from above…

  4. The Role of Digital Literacy Practices on Refugee Resettlement: The Case of Three Karen Brothers

    ERIC Educational Resources Information Center

    Gilhooly, Daniel; Lee, Eunbae

    2014-01-01

    This study explores the social and cultural uses of digital literacies by adolescent immigrants to cope with their new lives in the United States. This case study focuses on three adolescent ethnic Karen brothers. Two years of participant observations in their home and Karen community, accompanied by formal and informal interviews, served as the…

  5. My Brother as "Problem": Neoliberal Governmentality and Interventions for Black Young Men and Boys

    ERIC Educational Resources Information Center

    Dumas, Michael J.

    2016-01-01

    In this article, the author argues that the Obama Administration's My Brother's Keeper (MBK) initiative serves as an exemplar of neoliberal governmentality, in which Black young men and boys are constructed as essentially damaged, as problems in need of a technocratic public--private solution. More than simply an ideological imposition from above…

  6. The Irish Christian Brothers and the National Board of Education: Challenging the Myths

    ERIC Educational Resources Information Center

    McLaughlin, Denis

    2008-01-01

    For close to 170 years the general consensus from historians has been that Edmund Rice, who founded the Irish Christian Brothers in 1802, was an unenthusiastic applicant to the National Board of Education in Ireland in 1832 and later withdrew his schools because he believed his education was incompatible with the philosophy underpinning the…

  7. Circuits of Spectacle: The Miller Brothers' 101 Ranch Real Wild West

    ERIC Educational Resources Information Center

    Fields, Alison

    2012-01-01

    The Miller Brothers' 101 Ranch Real Wild West show ran from 1906 to 1931, outlasting the famous Buffalo Bill's Wild West show by more than a decade. From its beginnings in Oklahoma Territory, the Real Wild West show traveled national and international circuits and built a broad roster of performers, including more than 150 American Indians. During…

  8. The Big Bang Theory

    SciTech Connect

    Lincoln, Don

    2014-09-30

    The Big Bang is the name of the most respected theory of the creation of the universe. Basically, the theory says that the universe was once smaller and denser and has been expending for eons. One common misconception is that the Big Bang theory says something about the instant that set the expansion into motion, however this isn’t true. In this video, Fermilab’s Dr. Don Lincoln tells about the Big Bang theory and sketches some speculative ideas about what caused the universe to come into existence.

  9. The Big Bang Theory

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The Big Bang is the name of the most respected theory of the creation of the universe. Basically, the theory says that the universe was once smaller and denser and has been expending for eons. One common misconception is that the Big Bang theory says something about the instant that set the expansion into motion, however this isn’t true. In this video, Fermilab’s Dr. Don Lincoln tells about the Big Bang theory and sketches some speculative ideas about what caused the universe to come into existence.

  10. Genomic sister-disorders of neurodevelopment: an evolutionary approach

    PubMed Central

    Crespi, Bernard; Summers, Kyle; Dorus, Steve

    2009-01-01

    Genomic sister-disorders are defined here as diseases mediated by duplications versus deletions of the same region. Such disorders can provide unique information concerning the genomic underpinnings of human neurodevelopment because effects of diametric variation in gene copy number on cognitive and behavioral phenotypes can be inferred. We describe evidence from the literature on deletions versus duplications for the regions underlying the best-known human neurogenetic sister-disorders, including Williams syndrome, Velocardiofacial syndrome, and Smith–Magenis syndrome, as well as the X-chromosomal conditions Klinefelter and Turner syndromes. These data suggest that diametric copy-number alterations can, like diametric alterations to imprinted genes, generate contrasting phenotypes associated with autistic-spectrum and psychotic-spectrum conditions. Genomically based perturbations to the development of the human social brain are thus apparently mediated to a notable degree by effects of variation in gene copy number. We also conducted the first analyses of positive selection for genes in the regions affected by these disorders. We found evidence consistent with adaptive evolution of protein-coding genes, or selective sweeps, for three of the four sets of sister-syndromes analyzed. These studies of selection facilitate identification of candidate genes for the phenotypes observed and lend a novel evolutionary dimension to the analysis of human cognitive architecture and neurogenetic disorders. PMID:25567849

  11. Southall Black Sisters. Hannana Siddiqui speaks to Rasna Warah.

    PubMed

    Warah, R

    1994-01-01

    Southall Black Sisters, an organization for Asian and Afro-Caribbean women in Great Britain, was established in 1979 at the height of anti-racist protests to address the otherwise neglected issue of women's oppression. The group has campaigned against discriminatory immigration laws, illegal virginity tests at Heathrow airport, domestic violence, and other issues of particular concern to British Asian women. Women who migrate to England for an arranged marriage must remain with their husband at least 1 year or face deportation and denial of any public assistance, placing them at risk of unreported domestic violence. Southall Black Sisters has attempted to raise the public consciousness about domestic violence as a criminal issue and garner support for Asian women who leave abusive husbands. However, no support has been forthcoming from the anti-racist movement, which fears that publicity on domestic violence will create a racist backlash against Asian men. More support has been available for the group's campaign to protect battered women who kill their husbands by removing from the law on provocation the need for an immediate response. Another campaign has involved protests against "bounty hunters" hired by Asian families to return girls who have escaped from arranged marriages in their home country or sexual abuse within their family. Southall Black Sisters attributes many of the problems faced by its clients to a rise in religious fundamentalism and Muslim attempts to reverse the gains of the feminist movement.

  12. [The umbilical metastasis. Sister Mary Joseph and her time].

    PubMed

    Trebing, D; Göring, H-D

    2004-02-01

    Although Baluff in 1854 and Nelaton in 1860 had already described umbilical metastases, the best known description of the metastasis of carcinomas to this site as "trouser button navel" was published in 1928 by William James Mayo (1861-1939), son of William Worrall Mayo (1815-1911), the founder of the Mayo Clinic in Rochester, Minnesota, This phenomenon is supposed to have been pointed out to Mayo by his long-serving head surgical nurse Sister Mary Joseph (1856-1939). The English surgeon Hamilton Bailey, in his famous textbook "Physical Signs in Clinical Surgery" in 1949, coined the term "Sister Joseph's nodule" for an umbilical metastasis. The expression has become widely accepted and used. Sister Mary Joseph, daughter of Irish immigrants, belonged to the 3rd order of the Holy Francis, was distinguished for her skills, intelligence and devotion to nursing which was also her calling. She worked for many decades at the world-famous Mayo Clinic and taught generations of young nurses. In recent years, the original surgical building at Saint Mary's Hospital has been named "Joseph Building" in her memory. Among the numerous eponyms occurring in the dermatology and the medicine, the association with the name of a nurse represents beyond doubt a special feature.

  13. Broad phylogenomic sampling and the sister lineage of land plants.

    PubMed

    Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F

    2012-01-01

    The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae.

  14. Cryptography for Big Data Security

    DTIC Science & Technology

    2015-07-13

    Cryptography for Big Data Security Book Chapter for Big Data: Storage, Sharing, and Security (3S) Distribution A: Public Release Ariel Hamlin1 Nabil...Email: arkady@ll.mit.edu ii Contents 1 Cryptography for Big Data Security 1 1.1 Introduction...48 Chapter 1 Cryptography for Big Data Security 1.1 Introduction With the amount

  15. The Big Bang Singularity

    NASA Astrophysics Data System (ADS)

    Ling, Eric

    The big bang theory is a model of the universe which makes the striking prediction that the universe began a finite amount of time in the past at the so called "Big Bang singularity." We explore the physical and mathematical justification of this surprising result. After laying down the framework of the universe as a spacetime manifold, we combine physical observations with global symmetrical assumptions to deduce the FRW cosmological models which predict a big bang singularity. Next we prove a couple theorems due to Stephen Hawking which show that the big bang singularity exists even if one removes the global symmetrical assumptions. Lastly, we investigate the conditions one needs to impose on a spacetime if one wishes to avoid a singularity. The ideas and concepts used here to study spacetimes are similar to those used to study Riemannian manifolds, therefore we compare and contrast the two geometries throughout.

  16. Sharing big biomedical data.

    PubMed

    Toga, Arthur W; Dinov, Ivo D

    The promise of Big Biomedical Data may be offset by the enormous challenges in handling, analyzing, and sharing it. In this paper, we provide a framework for developing practical and reasonable data sharing policies that incorporate the sociological, financial, technical and scientific requirements of a sustainable Big Data dependent scientific community. Many biomedical and healthcare studies may be significantly impacted by using large, heterogeneous and incongruent datasets; however there are significant technical, social, regulatory, and institutional barriers that need to be overcome to ensure the power of Big Data overcomes these detrimental factors. Pragmatic policies that demand extensive sharing of data, promotion of data fusion, provenance, interoperability and balance security and protection of personal information are critical for the long term impact of translational Big Data analytics.

  17. Thinking big thoughts

    NASA Astrophysics Data System (ADS)

    Vedral, Vlatko

    2016-08-01

    The short synopsis of The Big Picture by Sean Carroll is that it explores the question of whether science can explain everything in the world, and analyses the emerging reality that such an explanation entails.

  18. Big Baby, Heavier Kid?

    MedlinePlus

    ... not prove that being a big baby caused obesity in children, however. The University of Virginia Children's Hospital study ... Human Services. More Health News on Child Nutrition Obesity in Children Recent Health News Related MedlinePlus Health Topics Child ...

  19. Nonrandom sister chromatid segregation of sex chromosomes in Drosophila male germline stem cells.

    PubMed

    Yamashita, Yukiko M

    2013-05-01

    Sister chromatids are the product of DNA replication, which is assumed to be a very precise process. Therefore, sister chromatids should be exact copies of each other. However, reports have indicated that sister chromatids are segregated nonrandomly during cell division, suggesting that sister chromatids are not the same, although their DNA sequences are the same. Researchers have speculated that stem cells may retain template strands to avoid replication-induced mutations. An alternative proposal is that cells may segregate distinct epigenetic information carried on sister chromatids. Recently, we found that Drosophila male germline stem cells segregate sister chromatids of X and Y chromosomes with a strong bias. We discuss this finding in relation to existing models for nonrandom sister chromatid segregation.

  20. Big data need big theory too.

    PubMed

    Coveney, Peter V; Dougherty, Edward R; Highfield, Roger R

    2016-11-13

    The current interest in big data, machine learning and data analytics has generated the widespread impression that such methods are capable of solving most problems without the need for conventional scientific methods of inquiry. Interest in these methods is intensifying, accelerated by the ease with which digitized data can be acquired in virtually all fields of endeavour, from science, healthcare and cybersecurity to economics, social sciences and the humanities. In multiscale modelling, machine learning appears to provide a shortcut to reveal correlations of arbitrary complexity between processes at the atomic, molecular, meso- and macroscales. Here, we point out the weaknesses of pure big data approaches with particular focus on biology and medicine, which fail to provide conceptual accounts for the processes to which they are applied. No matter their 'depth' and the sophistication of data-driven methods, such as artificial neural nets, in the end they merely fit curves to existing data. Not only do these methods invariably require far larger quantities of data than anticipated by big data aficionados in order to produce statistically reliable results, but they can also fail in circumstances beyond the range of the data used to train them because they are not designed to model the structural characteristics of the underlying system. We argue that it is vital to use theory as a guide to experimental design for maximal efficiency of data collection and to produce reliable predictive models and conceptual knowledge. Rather than continuing to fund, pursue and promote 'blind' big data projects with massive budgets, we call for more funding to be allocated to the elucidation of the multiscale and stochastic processes controlling the behaviour of complex systems, including those of life, medicine and healthcare.This article is part of the themed issue 'Multiscale modelling at the physics-chemistry-biology interface'. © 2015 The Authors.

  1. Big data need big theory too

    PubMed Central

    Dougherty, Edward R.; Highfield, Roger R.

    2016-01-01

    The current interest in big data, machine learning and data analytics has generated the widespread impression that such methods are capable of solving most problems without the need for conventional scientific methods of inquiry. Interest in these methods is intensifying, accelerated by the ease with which digitized data can be acquired in virtually all fields of endeavour, from science, healthcare and cybersecurity to economics, social sciences and the humanities. In multiscale modelling, machine learning appears to provide a shortcut to reveal correlations of arbitrary complexity between processes at the atomic, molecular, meso- and macroscales. Here, we point out the weaknesses of pure big data approaches with particular focus on biology and medicine, which fail to provide conceptual accounts for the processes to which they are applied. No matter their ‘depth’ and the sophistication of data-driven methods, such as artificial neural nets, in the end they merely fit curves to existing data. Not only do these methods invariably require far larger quantities of data than anticipated by big data aficionados in order to produce statistically reliable results, but they can also fail in circumstances beyond the range of the data used to train them because they are not designed to model the structural characteristics of the underlying system. We argue that it is vital to use theory as a guide to experimental design for maximal efficiency of data collection and to produce reliable predictive models and conceptual knowledge. Rather than continuing to fund, pursue and promote ‘blind’ big data projects with massive budgets, we call for more funding to be allocated to the elucidation of the multiscale and stochastic processes controlling the behaviour of complex systems, including those of life, medicine and healthcare. This article is part of the themed issue ‘Multiscale modelling at the physics–chemistry–biology interface’. PMID:27698035

  2. Review of Three Recent Randomized Trials of School-Based Mentoring: Making Sense of Mixed Findings. Social Policy Report. Volume 24, Number 3

    ERIC Educational Resources Information Center

    Wheeler, Marc E.; Keller, Thomas E.; DuBois, David L.

    2010-01-01

    Between 2007 and 2009, reports were released on the results of three separate large-scale random assignment studies of the effectiveness of school-based mentoring programs for youth. The studies evaluated programs implemented by Big Brothers Big Sisters of America (BBBSA) affiliates (Herrera et al., 2007), Communities In Schools of San Antonio,…

  3. School-Based Mentoring. A Closer Look

    ERIC Educational Resources Information Center

    Herrera, Carla

    2004-01-01

    With traditional mentoring programs working hard to attract new kinds of volunteers and schools facing increased pressure to help students succeed, school-based mentoring is a promising--and increasingly popular--approach. According to Big Brothers Big Sisters of America, the number of school-based matches grew from 27,000 in 1999 to 90,000 in…

  4. School-Based Mentoring Programs: Using Volunteers to Improve the Academic Outcomes of Underserved Students

    ERIC Educational Resources Information Center

    Bayer, Amanda; Grossman, Jean Baldwin; DuBois, David L.

    2013-01-01

    Previous research suggests that school-based mentoring programs like those offered by Big Brothers Big Sisters of America (BBBSA) yield small but statistically significant improvements in the academic performance of mentored students and in their beliefs in their own scholastic efficacy. The present study uses data from a randomized control trial…

  5. Teens for Literacy in Inner-City Schools.

    ERIC Educational Resources Information Center

    Berger, Allen

    1993-01-01

    Describes the Teens for Literacy project, in which teens come up with ideas to improve literacy in their schools. Notes that, in the nearly five years of the program, teens have developed a Big Brother/Big Sister reading program, selected and displayed posters in school corridors, developed videos promoting literacy, read with children, and…

  6. High School Teen Mentoring Handbook

    ERIC Educational Resources Information Center

    Alberta Advanced Education and Technology, 2009

    2009-01-01

    Big Brothers Big Sisters Edmonton & Area, in partnership with Alberta Advanced Education and Technology, are providing the High School Teen Mentoring Program, a school-based mentoring program where mentor-mentee matches meet for one hour per week to engage in relationship-building activities at an elementary school. This initiative aims to…

  7. Mainstreaming: A Model for Including Elementary Students in the Severely Handicapped Classroom.

    ERIC Educational Resources Information Center

    Almond, Patricia; And Others

    1979-01-01

    Using the concepts of normalization, mainstreaming, and individualized instruction, a big brother/big sister program was developed in which 16 severely handicapped autistic children (4 to 15 years old) were tutored by nonhandicapped and educable mentally retarded elementary students. (CL)

  8. What's in a Relationship? An Examination of Social Capital, Race and Class in Mentoring Relationships

    ERIC Educational Resources Information Center

    Gaddis, S. Michael

    2012-01-01

    After 25 years of intense scrutiny, social capital remains an important yet highly debated concept in social science research. This research uses data from youth and mentors in several chapters of Big Brothers/Big Sisters to assess the importance of different mentoring relationship characteristics in creating positive outcomes among youths. The…

  9. Culture, Context, and Innovation: A Kiwi Canuck Perspective

    ERIC Educational Resources Information Center

    Marshall, Dave; Shaver, Karen

    2010-01-01

    This commentary lends a global practitioner perspective on the utility of this volume to the efforts of mentors and mentees and mentoring program developers. Dave Marshall and Karen Shaver, of Big Brothers Big Sisters New Zealand and Canada, respectively, offer keen insights into the value of creating a shared language for discussing mentoring…

  10. Lean on Me.

    ERIC Educational Resources Information Center

    Black, Susan

    1999-01-01

    Mentoring programs cannot always obliterate deficiencies in adult/child relationships or better student achievement. Two successful programs are the Big Brother/Big Sister program and the Office of Juvenile Justice's Juvenile Mentoring Program. (JUMP). Social support, not social control, is essential. Sidebars contain program tips and selected…

  11. Meeting the Challenge of Doing an RCT Evaluation of Youth Mentoring in Ireland: A Journey in Mixed Methods

    ERIC Educational Resources Information Center

    Brady, Bernadine; O'Regan, Connie

    2009-01-01

    The youth mentoring program Big Brothers Big Sisters is one of the first social interventions involving youth in Ireland to be evaluated using a randomized controlled trial methodology. This article sets out the design process undertaken, describing how the research team came to adopt a concurrent embedded mixed methods design as a means of…

  12. The Impact of School-Based Mentoring on Youths with Different Relational Profiles

    ERIC Educational Resources Information Center

    Schwartz, Sarah E. O.; Rhodes, Jean E.; Chan, Christian S.; Herrera, Carla

    2011-01-01

    Associations between youths' relationship profiles and mentoring outcomes were explored in the context of a national, randomized study of 1,139 youths (54% female) in geographically diverse Big Brothers Big Sisters school-based mentoring programs. The sample included youths in Grades 4-9 from diverse racial and ethnic backgrounds, the majority of…

  13. Pathways of Influence in School-Based Mentoring: The Mediating Role of Parent and Teacher Relationships

    ERIC Educational Resources Information Center

    Chan, Christian S.; Rhodes, Jean E.; Howard, Waylon J.; Lowe, Sarah R.; Schwartz, Sarah E. O.; Herrera, Carla

    2013-01-01

    This study explores the pathways through which school-based mentoring relationships are associated with improvements in elementary and high school students' socio-emotional, academic, and behavioral outcomes. Participants in the study (N = 526) were part of a national evaluation of the Big Brothers Big Sisters school-based mentoring programs, all…

  14. Finding Fortune in Thirteen Out-of-School Time Programs: A Compendium of Education Programs and Practices.

    ERIC Educational Resources Information Center

    Trammel, Ming

    This research compendium summarizes and reviews the evaluations of 13 out-of-school time programs with positive outcomes for young people. The programs are (1) 4-H; (2) 21st Century Community Learning Centers; (3) The After-School Corporation; (4) Beacons; (5) BELL After School Instructional Curriculum; (6) Big Brothers Big Sisters of America; (7)…

  15. Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations

    PubMed Central

    Hall, Julie M.; Georgiades, Matthew J.; Hammond, Deborah A.; Feng, Xiaoting; Moustafa, Ahmed A.; Todd, Gabrielle

    2017-01-01

    We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD. PMID:28168069

  16. Two novel mutations on exon 8 and intron 65 of COL7A1 gene in two Chinese brothers result in recessive dystrophic epidermolysis bullosa.

    PubMed

    Lin, Ying; Chen, Xue-Jun; Liu, Wei; Gong, Bo; Xie, Jun; Xiong, Jun-Hao; Cheng, Jing; Duan, Xi-Ling; Lin, Zhao-Chun; Huang, Lu-Lin; Wan, Hui-Ying; Liu, Xiao-Qi; Song, Lin-Hong; Yang, Zheng-Lin

    2012-01-01

    Dystrophic epidermolysis bullosa is an inherited bullous dermatosis caused by the COL7A1 gene mutation in autosomal dominant or recessive mode. COL7A1 gene encodes type VII collagen - the main component of the anchoring fibrils at the dermal-epidermal junction. Besides the 730 mutations reported, we identified two novel COL7A1 gene mutations in a Chinese family, which caused recessive dystrophic epidermolysis bullosa (RDEB). The diagnosis was established histopathologically and ultrastructurally. After genomic DNA extraction from the peripheral blood sample of all subjects (5 pedigree members and 136 unrelated control individuals), COL7A1 gene screening was performed by polymerase chain reaction amplification and direct DNA sequencing of the whole coding exons and flanking intronic regions. Genetic analysis of the COL7A1 gene in affected individuals revealed compound heterozygotes with identical novel mutations. The maternal mutation is a 2-bp deletion at exon 8 (c.1006_1007delCA), leading to a subsequent reading frame-shift and producing a premature termination codon located 48 amino acids downstream in exon 9 (p.Q336EfsX48), consequently resulting in the truncation of 2561 amino acids downstream. This was only present in two affected brothers, but not in the other unaffected family members. The paternal mutation is a 1-bp deletion occurring at the first base of intron 65 (c.IVS5568+1delG) that deductively changes the strongly conserved GT dinucleotide at the 5' donor splice site, results in subsequent reading-through into intron 65, and creates a stop codon immediately following the amino acids encoded by exon 65 (GTAA→TAA). This is predicted to produce a truncated protein lacking of 1089 C-terminal amino acids downstream. The latter mutation was found in all family members except one of the two unaffected sisters. Both mutations were observed concurrently only in the two affected brothers. Neither mutation was discovered in 136 unrelated Chinese control

  17. Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers.

    PubMed

    Bandak, M; Jørgensen, N; Juul, A; Lauritsen, J; Kier, M G G; Mortensen, M S; Oturai, P S; Mortensen, J; Hojman, P; Helge, J W; Daugaard, G

    2017-07-01

    Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because of the fetal etiology of testicular cancer, familial unrelated healthy men might not be an optimal control group. The objective of this study was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III) criteria comprised the main outcome measures of the study. Median age was similar in testicular cancer survivors and their biological brothers [44 years (IQR 39-50) vs. 46 (40-53) years respectively (p = 0.1)]. In testicular cancer survivors, follow-up since treatment was 12 years (7-19). Serum levels of luteinizing hormone and follicle-stimulating hormone were elevated (p ≤ 0.001), while total testosterone, free testosterone, inhibin B and anti-Müllerian hormone were lower (p ≤ 0.001) in testicular cancer survivors than in their biological brothers. The prevalence of metabolic syndrome was similar and apart from HDL-cholesterol, which was lower in testicular cancer survivors (p = 0.01); there were no differences in the individual components of the metabolic syndrome between testicular cancer survivors and their brothers. In conclusion, gonadal function was impaired in testicular cancer survivors, while we did not detect any difference in the prevalence of metabolic syndrome between testicular cancer survivors and their biological brothers. © 2017 American

  18. Obstetric prognosis in sisters of preeclamptic women - implications for genetic linkage studies.

    PubMed

    Heiskanen, Nonna; Heinonen, Seppo; Kirkinen, Pertti

    2003-02-23

    BACKGROUND: To investigate obstetric prognosis in sisters of preeclamptic women. METHODS: We identified consecutive 635 sib pairs from the Birth Registry data of Kuopio University Hospital who had their first delivery between January 1989 and December 1999 in our institution. Of these, in 530 pairs both sisters had non-preeclamptic pregnancies (the reference group), in 63 pairs one of the sisters had preeclampsia and the unaffected sisters were studied (study group I). In 42 pairs both sister's first delivery was affected (study group II). Pregnancy outcome measures in these groups were compared. RESULTS: Unaffected sisters of the index patients had uncompromised fetal growth in their pregnancies, and overall, as good obstetric outcomes as in the reference group. The data on affected sisters of the index patients showed an increased prematurity rate, and increased incidences of low birth weight and small-for-gestational age infants, as expected. CONCLUSION: Unaffected sisters of the index patients had no signs of utero-placental insufficiency and they were at low risk with regard to adverse obstetric outcome, whereas affected sisters were high-risk. Clinically, affected versus unaffected status appears to be clear-cut in first-degree relatives regardless of their genetic susceptibility and unaffected sisters do not need special antepartum surveillance.

  19. Sisters who developed piloerection after administration of milnacipran.

    PubMed

    Matsuo, Nobuko; Hori, Satoko; Suehira, Mayu; Satoh, Hiroki; Miki, Akiko; Sawada, Yasufumi

    2016-03-01

    We previously reported the first case of piloerection in a patient receiving milnacipran hydrochloride (MLP). Here, we now present a second case of MLP-induced piloerection. We discuss this effect in terms of α1-adrenoceptor occupancy. After the first case of MLP-induced piloerection, we monitored occurrence of piloerection in our patients taking MLP. In response to our interview, a 43-year-old woman who had been prescribed MLP by a psychiatrist for depression mentioned that piloerection occurred frequently all over her body, starting soon after initiation of MLP administration (50 mg/day). Although she was concerned at the time, she assumed it might be related to her depression or to coldness in winter. She also mentioned that the incidence of piloerection increased with MLP dose escalation. The piloerection disappeared after several months. Interestingly, the previous patient and the current patient are biological sisters. Changes in α1-adrenoceptor occupancy by endogenous norepinephrine (as an index of the risk of piloerection) in the presence of MLP were estimated. The occupancy values increased with MLP dose escalation, in accordance with the patient's report of the phenomenon. other concomitant drugs, such as nortriptyline, had little effect. Since the two patients were sisters, genetic factors might influence the risk of piloerection. The incidence of piloerection appeared to increase with MLP dose escalation in this patient, who was the biological sister of the previously reported patient. Clinicians should recognize the possibility of MLP-induced piloerection in view of its potential impact on patients' quality of life and on drug compliance.

  20. FtsK actively segregates sister chromosomes in Escherichia coli.

    PubMed

    Stouf, Mathieu; Meile, Jean-Christophe; Cornet, François

    2013-07-02

    Bacteria use the replication origin-to-terminus polarity of their circular chromosomes to control DNA transactions during the cell cycle. Segregation starts by active migration of the region of origin followed by progressive movement of the rest of the chromosomes. The last steps of segregation have been studied extensively in the case of dimeric sister chromosomes and when chromosome organization is impaired by mutations. In these special cases, the divisome-associated DNA translocase FtsK is required. FtsK pumps chromosomes toward the dif chromosome dimer resolution site using polarity of the FtsK-orienting polar sequence (KOPS) DNA motifs. Assays based on monitoring dif recombination have suggested that FtsK acts only in these special cases and does not act on monomeric chromosomes. Using a two-color system to visualize pairs of chromosome loci in living cells, we show that the spatial resolution of sister loci is accurately ordered from the point of origin to the dif site. Furthermore, ordered segregation in a region ∼200 kb long surrounding dif depended on the oriented translocation activity of FtsK but not on the formation of dimers or their resolution. FtsK-mediated segregation required the MatP protein, which delays segregation of the dif-surrounding region until cell division. We conclude that FtsK segregates the terminus region of sister chromosomes whether they are monomeric or dimeric and does so in an accurate and ordered manner. Our data are consistent with a model in which FtsK acts to release the MatP-mediated cohesion and/or interaction with the division apparatus of the terminus region in a KOPS-oriented manner.

  1. Catholic Sister Nurses in Selma, Alabama, 1940–1972

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  2. Agenesis of the Gallbladder in Monozygotic Twin Sisters

    PubMed Central

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed “gallbladder agenesis.” Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274

  3. Agenesis of the Gallbladder in Monozygotic Twin Sisters.

    PubMed

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed "gallbladder agenesis." Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality.

  4. Lipschütz ulcers in twin sisters.

    PubMed

    Truchuelo, Maria T; Vano-Galván, Sergio; Alcántara, Javier; Pérez, Bibiana; Jaén, Pedro

    2012-01-01

    Lipschütz ulcer (LU) is an uncommon condition that usually affects prepubertal and pubertal girls. It can be misdiagnosed as a sexually transmitted disease or even as a sign of child abuse, causing great anxiety to patients and their families. We present two cases of LU consecutively affecting twin sisters. To our knowledge, this is the first case in two family members, supporting infectious transmission. We propose airborne transmission as the most probable cause in our cases. © 2012 Wiley Periodicals, Inc.

  5. District nursing sister attached to hospital surgical department.

    PubMed

    Hockey, L

    1970-04-18

    An experiment of attaching a district nursing sister to the surgical department of a general hospital was designed to show the use of the district nursing service for the after-care of patients discharged from hospital after surgical treatment. In a 15-week period about 590 bed days were saved, and only six out of 126 patients discharged early had to be readmitted. Most of the patients and the general practitioners who replied to questionaries about the scheme were in favour of it.

  6. Big Bend sees big environmental push

    SciTech Connect

    Blankinship, S.

    2007-10-15

    The 1800 MW Big Bend Power Station is a coal-fired facility in Tampa Bay, Florida, USA owned by Tampa Electric. It has four pulverized coal- fired steam units equipped with FGD scrubbers and electrostatic precipitators. Currently the addition of selective catalytic reduction (SCR) systems is under consideration. The Unit 4 SCR retrofit was completed in June 2007; the remaining three systems are scheduled for completion by 2010. Boiler draft systems will be modified to a balance draft design to accommodate the increased pressure drop of the new systems. 3-D computer models were developed to determine constructability due to the tight clearance at the site. 1 photo.

  7. Dr. Max King: the sad life and early death of Mackenzie King's physician brother

    PubMed Central

    Gray, C

    1998-01-01

    While researching her best-selling biography, Mrs. King: The Life and Times of Isabel Mackenzie King, CMAJ contributing editor Charlotte Gray discovered a wealth of information about Dr. Dougal Macdougall (Max) King. Although he never became as famous as his older brother Mackenzie, Gray presents a convincing argument that Dr. Max King's life and early death speak volumes about medicine and the medical profession at the turn of the century. She also argues that Mackenzie King's own life would have been much different had his brother not died at the too young age of 42. Gray's book was nominated for the Viacom Award, which honours the best nonfiction book published annually in Canada. PMID:9580741

  8. Brotherly Advice: Letters from Hugo to Paul Ehrenfest in his Final Years

    NASA Astrophysics Data System (ADS)

    Halpern, Paul

    2006-03-01

    At the start of the 1930s, theoretician Paul Ehrenfest spent much of his time traveling through America and Europe while engaged in a steady stream of lectures. This traveling phase coincided with a frantic and intense period of negative self-examination, financial difficulty, and various other personal concerns that would ultimately lead to his 1933 suicide. Throughout these final years, he kept up a steady correspondence with his brother Hugo, a physician based in Saint Louis. Ten years older than Paul, Hugo freely doled out frank psychological advice about subjects ranging from the proper treatment of children to the dangers of self-pity. Through a look at some of the letters exchanged between the two brothers, this talk will examine the role Hugo played during the dark final years of Paul Ehrenfest's life.

  9. Big data bioinformatics.

    PubMed

    Greene, Casey S; Tan, Jie; Ung, Matthew; Moore, Jason H; Cheng, Chao

    2014-12-01

    Recent technological advances allow for high throughput profiling of biological systems in a cost-efficient manner. The low cost of data generation is leading us to the "big data" era. The availability of big data provides unprecedented opportunities but also raises new challenges for data mining and analysis. In this review, we introduce key concepts in the analysis of big data, including both "machine learning" algorithms as well as "unsupervised" and "supervised" examples of each. We note packages for the R programming language that are available to perform machine learning analyses. In addition to programming based solutions, we review webservers that allow users with limited or no programming background to perform these analyses on large data compendia.

  10. Big data in biomedicine.

    PubMed

    Costa, Fabricio F

    2014-04-01

    The increasing availability and growth rate of biomedical information, also known as 'big data', provides an opportunity for future personalized medicine programs that will significantly improve patient care. Recent advances in information technology (IT) applied to biomedicine are changing the landscape of privacy and personal information, with patients getting more control of their health information. Conceivably, big data analytics is already impacting health decisions and patient care; however, specific challenges need to be addressed to integrate current discoveries into medical practice. In this article, I will discuss the major breakthroughs achieved in combining omics and clinical health data in terms of their application to personalized medicine. I will also review the challenges associated with using big data in biomedicine and translational science.

  11. Big Questions: Missing Antimatter

    SciTech Connect

    Lincoln, Don

    2013-08-27

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  12. Big Questions: Missing Antimatter

    ScienceCinema

    Lincoln, Don

    2016-07-12

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  13. Learning to Fly: The Wright Brothers' Adventure. A Guide for Educators and Students with Activities in Aeronautics

    NASA Technical Reports Server (NTRS)

    Storm, R.; Benson, T.; Galica, C.; McCredie, P.

    2003-01-01

    This guide was produced by the NASA Glenn Research Center Office of Educational Programs in Cleveland, OH, and the NASA Aerospace Educational Coordinating Committee. It includes activity modules for students, including the history of the Wright Brothers and their family in Dayton, Ohio and flight experimentation in Kitty Hawk, North Carolina. Student activities such as building models of the Wright Brothers glider and writing press releases of the initial flight are included.

  14. Renal tubular dysgenesis, absent nipples, and multiple malformations in three brothers: a new, lethal syndrome.

    PubMed

    Hisama, F M; Reyes-Mugica, M; Wargowski, D S; Thompson, K J; Mahoney, M J

    1998-12-04

    We report on three brothers with renal tubular dysgenesis and absent nipples, each also had other malformations including pre-auricular pits and a preauricular tag, branchial clefts, choanal atresia, pulmonary lobation anomaly, ventricular septal defect, type IIB interrupted aortic arch, absent gallbladder, absent thymus, parathyroid gland, accessory spleen, imperforate anus, clinodactyly, and broad digits and small nails. All three infants died neonatally. This pattern of clinical malformations appears to be a previously unreported syndrome.

  15. X-linked mental retardation syndrome: Three brothers with the Brooks-Wisniewski-Brown syndrome

    SciTech Connect

    Morava, E.; Storcz, J.; Kosztolanyi, G.

    1996-07-12

    We report on 3 brothers with growth and mental retardation, bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, wide bulbous nose, small mouth, myopia, and spastic diplegia. The patients were born to normal and non-consanguineous parents. The similarity of our cases with those recently reported by Brooks et al. supports their suggestion that these patients are representative of a distinct entity. 8 refs., 3 figs., 1 tab.

  16. Osteosclerosis in two brothers with autosomal dominant pseudohypoparathyroidism type 1b: bone histomorphometric analysis.

    PubMed

    Sbrocchi, Anne Marie; Rauch, Frank; Lawson, Margaret L; Hadjiyannakis, Stasia; Lawrence, Sarah; Bastepe, Murat; Jüppner, Harald; Ward, Leanne Marie

    2011-02-01

    Pseudohypoparathyroidism (PHP) is a heterogeneous disorder characterized by hypocalcemia and hyperphosphatemia resulting from selective renal resistance to parathyroid hormone (PTH). One autosomal dominant form of PHP type 1b (PHP-Ib) is most frequently caused by a maternally inherited 3-kb deletion within STX16, the gene encoding syntaxin 16. To date, increased bone mineral density (BMD) has been described only in PHP type 1a, and there is a lack of detailed information on bone histomorphometry in PHP-Ib. The objective of this report was to present trans-iliac static and dynamic histomorphometry in two brothers with the 3-kb deletion in the STX16 region and elevated BMD. Observational study of two brothers (age 18.0 and 22.7 years) with the 3-kb STX16 deletion and increased BMD. The brothers had elevated PTH (146 pg/ml (15.6 pmol/l) and 102 pg/ml (10.9 pmol/l); normal: 10-64 pg/ml (1.1-6.8 pmol/l)) and striking osteosclerosis (lumbar spine areal BMD Z-scores: +5.4 and +4.9). Bone histomorphometry showed marked elevations in cortical width for both brothers (241 and 209% of the mean result expected for age), with elevations in the bone formation rate on the endocortical (119 and 260% of the healthy mean) and trabecular (220 and 190% of mean) surfaces. Our findings suggest that PTH in this PHP-Ib genotype can increase cortical thickness due to its anabolic effect on endocortical bone, and underscore the heterogeneity in the skeletal phenotype among patients with PHP-Ib.

  17. Narcolepsy with Cataplexy Mimicry: The Strange Case of Two Sisters

    PubMed Central

    Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe

    2013-01-01

    We report on two sisters, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyo-graphic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases. Citation: Pizza F; Vandi S; Poli F; Moghadam KK; Fran-ceschini C; Bellucci C; Cipolli C; Ingravallo F; Natalini G; Mignot E; Plazzi G. Narcolepsy with cataplexy mimicry: the strange case of two sisters. J Clin Sleep Med 2013;9(6):611-612. PMID:23772196

  18. Chromosome breakage and sister chromatid exchange analysis in computer operators

    SciTech Connect

    Butler, M.G.; Yost, J.; Jenkins, B.B.

    1987-01-01

    Chromosome breakage analysis with Mitomycin C (MMC) and sister chromatid exchanges (SCE) were obtained on 10 computer operators with computer exposure for a minimum of 3 hours per day for 4 years and 10 control subjects matched for age and personal lifestyle. No difference was found between the two groups in the total number of chromatid and chromosome aberrations in cells grown at 48 and/or 96 hours in Mitomycin C (20 or 50 ng/ml-final concentration). The average number of SCE per cell in approximately 30 cells from each person was 6.4 +/- 1.1 (mean +/- standard deviation) for the computer operators and 9.2 +/- 1.6 for the controls. This difference was significant (p < .001). The replicative index was significantly higher (p < .01) in computer operators than in control subjects. The number of SCE appeared not to be influenced by the years of computer exposure. Additional studies with larger sample sizes will be needed to identify if significant differences exist in cell kinetics and sister chromatid exchanges in individuals employed as computer operators.

  19. Two otherwise healthy young brothers present with intermittent claudication, just a coincidence?

    PubMed

    Clifford, Thomas; Moore, Jonathan

    2017-07-06

    Popliteal artery entrapment syndrome (PAES) is a recognised cause of lower limb peripheral arterial disease in young adults. We describe the cases of two otherwise healthy brothers who presented with the condition 5 years apart. The first brother, who is also the first author of this case report, presented aged 19 with worsening, right-sided, exercise-induced lower leg pain and transient foot pallor. Imaging confirmed PAES and irreversible localised arterial damage. Surgery was performed to release the entrapment and resect the section of diseased artery. The limb was revascularised using an autologous interposition saphenous vein graft. The second brother began experiencing left-sided, exercise-induced lower leg pain aged 24. Again, imaging revealed PAES and irreversible arterial damage. A similar revascularisation procedure was performed. Both siblings fully recovered and are symptom free. Arterial duplex scans have confirmed patent grafts. A correlation in siblings has only been reported in the literature five times previously. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  20. Big Joe Capsule Assembly Activities

    NASA Image and Video Library

    1959-08-01

    Big Joe Capsule Assembly Activities in 1959 at NASA Glenn Research Center (formerly NASA Lewis). Big Joe was an Atlas missile that successfully launched a boilerplate model of the Mercury capsule on September 9, 1959.

  1. Seeding considerations in restoring big sagebrush habitat

    Treesearch

    Scott M. Lambert

    2005-01-01

    This paper describes methods of managing or seeding to restore big sagebrush communities for wildlife habitat. The focus is on three big sagebrush subspecies, Wyoming big sagebrush (Artemisia tridentata ssp. wyomingensis), basin big sagebrush (Artemisia tridentata ssp. tridentata), and mountain...

  2. A Sobering Big Idea

    ERIC Educational Resources Information Center

    Wineburg, Sam

    2006-01-01

    Since Susan Adler, Alberta Dougan, and Jesus Garcia like "big ideas," the author offers one to ponder: young people in this country can not read with comprehension. The saddest thing about this crisis is that it is no secret. The 2001 results of the National Assessment of Educational Progress (NAEP) for reading, published in every major…

  3. The big bang

    NASA Astrophysics Data System (ADS)

    Silk, Joseph

    Our universe was born billions of years ago in a hot, violent explosion of elementary particles and radiation - the big bang. What do we know about this ultimate moment of creation, and how do we know it? Drawing upon the latest theories and technology, this new edition of The big bang, is a sweeping, lucid account of the event that set the universe in motion. Joseph Silk begins his story with the first microseconds of the big bang, on through the evolution of stars, galaxies, clusters of galaxies, quasars, and into the distant future of our universe. He also explores the fascinating evidence for the big bang model and recounts the history of cosmological speculation. Revised and updated, this new edition features all the most recent astronomical advances, including: Photos and measurements from the Hubble Space Telescope, Cosmic Background Explorer Satellite (COBE), and Infrared Space Observatory; the latest estimates of the age of the universe; new ideas in string and superstring theory; recent experiments on neutrino detection; new theories about the presence of dark matter in galaxies; new developments in the theory of the formation and evolution of galaxies; the latest ideas about black holes, worm holes, quantum foam, and multiple universes.

  4. The Big Sky inside

    ERIC Educational Resources Information Center

    Adams, Earle; Ward, Tony J.; Vanek, Diana; Marra, Nancy; Hester, Carolyn; Knuth, Randy; Spangler, Todd; Jones, David; Henthorn, Melissa; Hammill, Brock; Smith, Paul; Salisbury, Rob; Reckin, Gene; Boulafentis, Johna

    2009-01-01

    The University of Montana (UM)-Missoula has implemented a problem-based program in which students perform scientific research focused on indoor air pollution. The Air Toxics Under the Big Sky program (Jones et al. 2007; Adams et al. 2008; Ward et al. 2008) provides a community-based framework for understanding the complex relationship between poor…

  5. Thinking Big, Aiming High

    ERIC Educational Resources Information Center

    Berkeley, Viv

    2010-01-01

    What do teachers, providers and policymakers need to do in order to support disabled learners to "think big and aim high"? That was the question put to delegates at NIACE's annual disability conference. Some clear themes emerged, with delegates raising concerns about funding, teacher training, partnership-working and employment for disabled…

  6. The Big Fish

    ERIC Educational Resources Information Center

    DeLisle, Rebecca; Hargis, Jace

    2005-01-01

    The Killer Whale, Shamu jumps through hoops and splashes tourists in hopes for the big fish, not because of passion, desire or simply the enjoyment of doing so. What would happen if those fish were obsolete? Would this killer whale be able to find the passion to continue to entertain people? Or would Shamu find other exciting activities to do…

  7. Big-City Rules

    ERIC Educational Resources Information Center

    Gordon, Dan

    2011-01-01

    When it comes to implementing innovative classroom technology programs, urban school districts face significant challenges stemming from their big-city status. These range from large bureaucracies, to scalability, to how to meet the needs of a more diverse group of students. Because of their size, urban districts tend to have greater distance…

  8. The Big Sky inside

    ERIC Educational Resources Information Center

    Adams, Earle; Ward, Tony J.; Vanek, Diana; Marra, Nancy; Hester, Carolyn; Knuth, Randy; Spangler, Todd; Jones, David; Henthorn, Melissa; Hammill, Brock; Smith, Paul; Salisbury, Rob; Reckin, Gene; Boulafentis, Johna

    2009-01-01

    The University of Montana (UM)-Missoula has implemented a problem-based program in which students perform scientific research focused on indoor air pollution. The Air Toxics Under the Big Sky program (Jones et al. 2007; Adams et al. 2008; Ward et al. 2008) provides a community-based framework for understanding the complex relationship between poor…

  9. Big Enough for Everyone?

    ERIC Educational Resources Information Center

    Coote, Anna

    2010-01-01

    The UK's coalition government wants to build a "Big Society." The Prime Minister says "we are all in this together" and building it is the responsibility of every citizen as well as every government department. The broad vision is welcome, but everything depends on how the vision is translated into policy and practice. The…

  10. A Big Bang Lab

    ERIC Educational Resources Information Center

    Scheider, Walter

    2005-01-01

    The February 2005 issue of The Science Teacher (TST) reminded everyone that by learning how scientists study stars, students gain an understanding of how science measures things that can not be set up in lab, either because they are too big, too far away, or happened in a very distant past. The authors of "How Far are the Stars?" show how the…

  11. A Big Bang Lab

    ERIC Educational Resources Information Center

    Scheider, Walter

    2005-01-01

    The February 2005 issue of The Science Teacher (TST) reminded everyone that by learning how scientists study stars, students gain an understanding of how science measures things that can not be set up in lab, either because they are too big, too far away, or happened in a very distant past. The authors of "How Far are the Stars?" show how the…

  12. Big Enough for Everyone?

    ERIC Educational Resources Information Center

    Coote, Anna

    2010-01-01

    The UK's coalition government wants to build a "Big Society." The Prime Minister says "we are all in this together" and building it is the responsibility of every citizen as well as every government department. The broad vision is welcome, but everything depends on how the vision is translated into policy and practice. The…

  13. The Big Fish

    ERIC Educational Resources Information Center

    DeLisle, Rebecca; Hargis, Jace

    2005-01-01

    The Killer Whale, Shamu jumps through hoops and splashes tourists in hopes for the big fish, not because of passion, desire or simply the enjoyment of doing so. What would happen if those fish were obsolete? Would this killer whale be able to find the passion to continue to entertain people? Or would Shamu find other exciting activities to do…

  14. Countering misinformation concerning big sagebrush

    Treesearch

    Bruce L Welch; Craig Criddle

    2003-01-01

    This paper examines the scientific merits of eight axioms of range or vegetative management pertaining to big sagebrush. These axioms are: (1) Wyoming big sagebrush (Artemisia tridentata ssp. wyomingensis) does not naturally exceed 10 percent canopy cover and mountain big sagebrush (A. t. ssp. vaseyana) does not naturally exceed 20 percent canopy...

  15. Big Data and Chemical Education

    ERIC Educational Resources Information Center

    Pence, Harry E.; Williams, Antony J.

    2016-01-01

    The amount of computerized information that organizations collect and process is growing so large that the term Big Data is commonly being used to describe the situation. Accordingly, Big Data is defined by a combination of the Volume, Variety, Velocity, and Veracity of the data being processed. Big Data tools are already having an impact in…

  16. Big Data and Chemical Education

    ERIC Educational Resources Information Center

    Pence, Harry E.; Williams, Antony J.

    2016-01-01

    The amount of computerized information that organizations collect and process is growing so large that the term Big Data is commonly being used to describe the situation. Accordingly, Big Data is defined by a combination of the Volume, Variety, Velocity, and Veracity of the data being processed. Big Data tools are already having an impact in…

  17. Business and Science - Big Data, Big Picture

    NASA Astrophysics Data System (ADS)

    Rosati, A.

    2013-12-01

    Data Science is more than the creation, manipulation, and transformation of data. It is more than Big Data. The business world seems to have a hold on the term 'data science' and, for now, they define what it means. But business is very different than science. In this talk, I address how large datasets, Big Data, and data science are conceptually different in business and science worlds. I focus on the types of questions each realm asks, the data needed, and the consequences of findings. Gone are the days of datasets being created or collected to serve only one purpose or project. The trick with data reuse is to become familiar enough with a dataset to be able to combine it with other data and extract accurate results. As a Data Curator for the Advanced Cooperative Arctic Data and Information Service (ACADIS), my specialty is communication. Our team enables Arctic sciences by ensuring datasets are well documented and can be understood by reusers. Previously, I served as a data community liaison for the North American Regional Climate Change Assessment Program (NARCCAP). Again, my specialty was communicating complex instructions and ideas to a broad audience of data users. Before entering the science world, I was an entrepreneur. I have a bachelor's degree in economics and a master's degree in environmental social science. I am currently pursuing a Ph.D. in Geography. Because my background has embraced both the business and science worlds, I would like to share my perspectives on data, data reuse, data documentation, and the presentation or communication of findings. My experiences show that each can inform and support the other.

  18. How Big Are "Martin's Big Words"? Thinking Big about the Future.

    ERIC Educational Resources Information Center

    Gardner, Traci

    "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." tells of King's childhood determination to use "big words" through biographical information and quotations. In this lesson, students in grades 3 to 5 explore information on Dr. King to think about his "big" words, then they write about their own…

  19. Telomere sister chromatid exchange in telomerase deficient murine cells

    SciTech Connect

    Wang, Yisong; Giannone, Richard J; Liu, Yie

    2005-01-01

    We have recently demonstrated that several types of genomic rearrangements (i.e., telomere sister chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape 'end crisis'. However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.

  20. A Bangladeshi family with three sisters 'Bombay' or Oh phenotype.

    PubMed

    Rahman, M; Abdullah, A Z; Husain, M; Hague, K M; Hossain, M M

    1990-12-01

    Three sisters in a same family (MIAH FAMILY) are of 'Bombay' phenotype. These being the first known female examples of 'Bombay' blood group have been detected in Bangladesh. As predicted by current theory their red cells are Le(a+b-) and their saliva do not contain any of the antigens A, B and H except Lea substance. Family studies showed that individuals with 'Bombay' or Oh phenotype may have A or B gene which are not expressed. This very particular type of blood is one of the rarest in any other parts of world except in India. Due to the presence of anti-H antibody in the plasma of Oh phenotype, when considering such patients for transfusion only blood of identical Bombay type can be safely transfused.

  1. Sister chromatid exchange, DNA repair, and single-gene mutation

    SciTech Connect

    Carrano, A.V.; Thompson, L.H.

    1982-01-01

    Sister chromatid exchange (SCE) has been studied in cultured mammalian cells with regard to the nature of the inducing lesion, mutation induction, and factors that modify the observed frequency following mutagen exposure, SCEs can be induced by a wide spectrum of DNA lesions and, for nine agents examined, the frequency of induced SCE is linearly related to induced single-gene mutation. Further, a deficiency in DNA repair may alter the expression of both SCE and mutation in a qualitatively similar manner. The frequency of SCE induced by mitomycin-C is suppressed in heterochromatic relative to euchromatin and, in nondividing lymphocytes, the lesions leading to the formation of SCEs may persist for several months.

  2. Mercury poisoning in two 13-year-old twin sisters

    PubMed Central

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-01-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis. PMID:26109979

  3. Mercury poisoning in two 13-year-old twin sisters.

    PubMed

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-03-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis.

  4. Sister chromatid exchange in Polish White improved goats (Capra hircus).

    PubMed

    Wójcik, Ewa; Smalec, Elzbieta

    2012-01-01

    The study was aimed at evaluating the frequency of spontaneous sister chromatid exchange in Polish White Improved goats (Capra hircus). The mean number of SCEs/cell was 2.73 +/- 1.84. The effect of sex and age on SCE incidence was also investigated. No statistically significant differences in the number of SCEs/cell were observed between the males and females. On the other hand, age was found to significantly influence SCE frequency. A lower SCE frequency was observed in younger goats. A positive correlation between chromosome length and SCE number was identified. The longer the chromosome, the more exchanges occurred. The highest number of SCEs was observed in the interstitial region, the lowest in the distal area.

  5. Narcolepsy with cataplexy mimicry: the strange case of two sisters.

    PubMed

    Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe

    2013-06-15

    We report on two sisters, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyographic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases.

  6. Increased levels of sister chromatid exchanges in military aircraft pilots.

    PubMed

    Silva, M J; Carothers, A; Castelo Branco, N; Dias, A; Boavida, M G

    1999-04-26

    Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-performance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SCEs (high-frequency cells, HFCs) revealed a significant difference between pilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no significant differences either between pilots and controls or between smokers and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibration. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man.

  7. Sisters in Science: Confronting Equity in Science and Mathematics Education

    NASA Astrophysics Data System (ADS)

    Hammrich, Penny L.; Richardson, Greer M.; Livingston, Beverly D.

    The Sisters in Science (SIS) program seeks to increase elementary school girls' interest and achievement in science and mathematics, create a more positive learning climate for minority school girls and their families on academic and community/social levels, and increase the knowledge base and understanding of parents with respect to their influence in promoting girls' interest and achievement in science and mathematics. This article reports on how 577 fourth grade girls changed their interest and achievement in science and mathematics during their involvement in year 1 of the program. Findings show that the girls started the program with positive attitudes and perceptions of science and about science career possibilities. The girls significantly (p < 0.001) increased their science and mathematics skill levels after having participated in the program. It could be stated that the girls' achievement scores on the skills test increased significantly because the girls' attitudes and perceptions were positive before program implementation.

  8. Sister Mary Joseph's nodule as initial pancreatic cancer manifestation.

    PubMed

    Vallejo Bernad, Cristina; Casamayor Franco, María Carmen; Hakim Alonso, Sofía

    2017-02-01

    We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis. Skin metastasis is a rare sign usually reflecting a carcinoma of unknown origin. Umbilical skin metastasis, called Sister Mary Joseph´s nodule, reflect an intra-abdominal tumor, being pancreatic cancer strange.

  9. Youths' Caretaking of Their Adolescent Sisters' Children: Results from Two Longitudinal Studies

    ERIC Educational Resources Information Center

    East, Patricia L.; Weisner, Thomas S.; Slonim, Ashley

    2009-01-01

    The extent and experiences of youths' caretaking of their adolescent sisters' children have been assessed in two longitudinal studies. The first study examines the caretaking patterns of 132 Latino and African American youth during middle and late adolescence. The second study involves 110 Latino youth whose teenage sister has recently given…

  10. Addressing the Apparent Paradox of the Catholic Sister Principal: 1940-1965

    ERIC Educational Resources Information Center

    O'Donoghue, Tom; Harford, Judith

    2013-01-01

    A body of scholarship on the history of the lives of Catholic teaching sisters has thrown up various challenges to educational historians. One challenge can be posed by asking how teaching sisters were able to go on to take up leadership positions. This is prompted by the observation that a particular body of literature for the period 1940-1965…

  11. The Big One

    NASA Image and Video Library

    2017-03-13

    Mimas' gigantic crater Herschel lies near the moon's limb in this Cassini view. A big enough impact could potentially break up a moon. Luckily for Mimas, whatever created Herschel was not quite big enough to cause that level of disruption. When large impacts happen, they deliver tremendous amounts of energy -- sometimes enough to cause global destruction. Even impacts that are not catastrophic can leave enormous, near-permanent scars on bodies like Mimas (246 miles or 396 kilometers across). This view looks toward the anti-Saturn hemisphere of Mimas. North on Mimas is up and rotated 32 degrees to the left. The image was taken in visible light with the Cassini spacecraft narrow-angle camera on Nov. 19, 2016. The view was acquired at a distance of approximately 53,000 miles (85,000 kilometers) from Mimas. Image scale is 1,677 feet (511 meters) per pixel. http://photojournal.jpl.nasa.gov/catalog/PIA20523

  12. A holographic big bang?

    NASA Astrophysics Data System (ADS)

    Afshordi, N.; Mann, R. B.; Pourhasan, R.

    2015-11-01

    We present a cosmological model in which the Universe emerges out of the collapse of a five-dimensional (5D) star as a spherical three-brane. The initial singularity of the big bang becomes hidden behind a causal horizon. Near scale-invariant primordial curvature perturbations can be induced on the brane via a thermal atmosphere that is in equilibrium with the brane, circumventing the need for a separate inflationary process and providing an important test of the model.

  13. DARPA's Big Mechanism program.

    PubMed

    Cohen, Paul R

    2015-07-16

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

  14. The Next Big Idea

    PubMed Central

    2013-01-01

    Abstract George S. Eisenbarth will remain in our memories as a brilliant scientist and great collaborator. His quest to discover the cause and prevention of type 1 (autoimmune) diabetes started from building predictive models based on immunogenetic markers. Despite his tremendous contributions to our understanding of the natural history of pre-type 1 diabetes and potential mechanisms, George left us with several big questions to answer before his quest is completed. PMID:23786296

  15. Big Bang Circus

    NASA Astrophysics Data System (ADS)

    Ambrosini, C.

    2011-06-01

    Big Bang Circus is an opera I composed in 2001 and which was premiered at the Venice Biennale Contemporary Music Festival in 2002. A chamber group, four singers and a ringmaster stage the story of the Universe confronting and interweaving two threads: how early man imagined it and how scientists described it. Surprisingly enough fancy, myths and scientific explanations often end up using the same images, metaphors and sometimes even words: a strong tension, a drumskin starting to vibrate, a shout…

  16. DARPA's Big Mechanism program

    NASA Astrophysics Data System (ADS)

    Cohen, Paul R.

    2015-07-01

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

  17. Big3. Editorial

    PubMed Central

    Lehmann, Christoph U.; Séroussi, Brigitte; Jaulent, Marie-Christine

    2014-01-01

    Summary Objectives To provide an editorial introduction into the 2014 IMIA Yearbook of Medical Informatics with an overview of the content, the new publishing scheme, and upcoming 25th anniversary. Methods A brief overview of the 2014 special topic, Big Data - Smart Health Strategies, and an outline of the novel publishing model is provided in conjunction with a call for proposals to celebrate the 25th anniversary of the Yearbook. Results ‘Big Data’ has become the latest buzzword in informatics and promise new approaches and interventions that can improve health, well-being, and quality of life. This edition of the Yearbook acknowledges the fact that we just started to explore the opportunities that ‘Big Data’ will bring. However, it will become apparent to the reader that its pervasive nature has invaded all aspects of biomedical informatics – some to a higher degree than others. It was our goal to provide a comprehensive view at the state of ‘Big Data’ today, explore its strengths and weaknesses, as well as its risks, discuss emerging trends, tools, and applications, and stimulate the development of the field through the aggregation of excellent survey papers and working group contributions to the topic. Conclusions For the first time in history will the IMIA Yearbook be published in an open access online format allowing a broader readership especially in resource poor countries. For the first time, thanks to the online format, will the IMIA Yearbook be published twice in the year, with two different tracks of papers. We anticipate that the important role of the IMIA yearbook will further increase with these changes just in time for its 25th anniversary in 2016. PMID:24853037

  18. Big Data Technologies

    PubMed Central

    Bellazzi, Riccardo; Dagliati, Arianna; Sacchi, Lucia; Segagni, Daniele

    2015-01-01

    The so-called big data revolution provides substantial opportunities to diabetes management. At least 3 important directions are currently of great interest. First, the integration of different sources of information, from primary and secondary care to administrative information, may allow depicting a novel view of patient’s care processes and of single patient’s behaviors, taking into account the multifaceted nature of chronic care. Second, the availability of novel diabetes technologies, able to gather large amounts of real-time data, requires the implementation of distributed platforms for data analysis and decision support. Finally, the inclusion of geographical and environmental information into such complex IT systems may further increase the capability of interpreting the data gathered and extract new knowledge from them. This article reviews the main concepts and definitions related to big data, it presents some efforts in health care, and discusses the potential role of big data in diabetes care. Finally, as an example, it describes the research efforts carried on in the MOSAIC project, funded by the European Commission. PMID:25910540

  19. Big Sky Carbon Atlas

    DOE Data Explorer

    The Big Sky Carbon Atlas is an online geoportal designed for you to discover, interpret, and access geospatial data and maps relevant to decision support and education on carbon sequestration in the Big Sky Region. In serving as the public face of the Partnership's spatial Data Libraries, the Atlas provides a gateway to geographic information characterizing CO2 sources, potential geologic sinks, terrestrial carbon fluxes, civil and energy infrastructure, energy use, and related themes. In addition to directly serving the BSCSP and its stakeholders, the Atlas feeds regional data to the NatCarb Portal, contributing to a national perspective on carbon sequestration. Established components of the Atlas include a gallery of thematic maps and an interactive map that allows you to: • Navigate and explore regional characterization data through a user-friendly interface • Print your map views or publish them as PDFs • Identify technical references relevant to specific areas of interest • Calculate straight-line or pipeline-constrained distances from point sources of CO2 to potential geologic sink features • Download regional data layers (feature under development) (Acknowledgment to the Big Sky Carbon Sequestration Partnership (BSCSP); see home page at http://www.bigskyco2.org/)

  20. Disaggregating asthma: Big investigation versus big data.

    PubMed

    Belgrave, Danielle; Henderson, John; Simpson, Angela; Buchan, Iain; Bishop, Christopher; Custovic, Adnan

    2017-02-01

    We are facing a major challenge in bridging the gap between identifying subtypes of asthma to understand causal mechanisms and translating this knowledge into personalized prevention and management strategies. In recent years, "big data" has been sold as a panacea for generating hypotheses and driving new frontiers of health care; the idea that the data must and will speak for themselves is fast becoming a new dogma. One of the dangers of ready accessibility of health care data and computational tools for data analysis is that the process of data mining can become uncoupled from the scientific process of clinical interpretation, understanding the provenance of the data, and external validation. Although advances in computational methods can be valuable for using unexpected structure in data to generate hypotheses, there remains a need for testing hypotheses and interpreting results with scientific rigor. We argue for combining data- and hypothesis-driven methods in a careful synergy, and the importance of carefully characterized birth and patient cohorts with genetic, phenotypic, biological, and molecular data in this process cannot be overemphasized. The main challenge on the road ahead is to harness bigger health care data in ways that produce meaningful clinical interpretation and to translate this into better diagnoses and properly personalized prevention and treatment plans. There is a pressing need for cross-disciplinary research with an integrative approach to data science, whereby basic scientists, clinicians, data analysts, and epidemiologists work together to understand the heterogeneity of asthma.

  1. The geography and ecology of plant speciation: range overlap and niche divergence in sister species.

    PubMed

    Anacker, Brian L; Strauss, Sharon Y

    2014-03-07

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under 'budding' speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister-non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities.

  2. Hoarding, hermitage, and the law: why we love the collyer brothers.

    PubMed

    Weiss, Kenneth J

    2010-01-01

    Interest in hoarding behavior has intensified, as it works its way through DSM-V deliberations and treatment models. Meanwhile, both documentarians and fiction writers have embraced accounts of individuals with disposophobia and romanticized versions of the Collyer brothers, the Hermits of Harlem. In this article, I examine the range of media and professional attention given to hoarders and their problems and then focus on a potential role for forensic mental health professionals. The psycholegal problems of hoarders include health and zoning code violations that evolve into criminal charges, civil commitment, questions of animal cruelty, landlord-tenant disputes, divorce and custody evaluations, testamentary capacity, and child-neglect charges.

  3. Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers.

    PubMed

    Libernini, Laura; Lupis, Chiara; Mastrangelo, Mario; Carrozzo, Rosalba; Santorelli, Filippo Maria; Inghilleri, Maurizio; Leuzzi, Vincenzo

    2012-08-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE, MIM 603041) is an autosomal recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP). Clinical features of MNGIE include gastrointestinal dysmotility, cachexia, ptosis or ophthalmoparesis, peripheral neuropathy, diffuse leukoencephalopathy, and signs of mitochondrial dysfunction in tissues. We report the clinical and molecular findings in two brothers in whom novel TYMP gene mutations (c.215-13_215delinsGCGTGA; c.1159 + 2T > A) were associated with different clinical presentations and outcomes.

  4. Superfund record of decision (EPA Region 1): Burgess Brothers Landfill, Woodford, VT, September 25, 1998

    SciTech Connect

    1999-03-01

    This Decision document presents the selected remedial action for the Burgess Brothers Superfund Site in Bennington and Woodford, Vermont. The remedial measures described in this ROD will minimize further migration of contamination into the groundwater and surface water, will eliminate the potential for direct contact and/or incidental ingestion of the material within the landfill, will control landfill gas and prevent exposure to landfill gas containing hazardous substances, and will replace any portion of wetlands destroyed as a result of implementing the selected remedy. The selected remedy consists of operating and maintaining controls to prevent exposure to contaminated soil and to achieve the restoration of groundwater and the protection of surface water.

  5. The KBG syndrome: follow-up data on three affected brothers.

    PubMed

    Soekarman, D; Volcke, P; Fryns, J P

    1994-10-01

    In this report we present follow-up data on a family in which several members were found to have short stature, craniofacial anomalies and dento-skeletal abnormalities (KBG-syndrome). As adults, the three affected brothers of the original report are moderately to severely mentally retarded. Their phenotype with a distinct craniofacial appearance did not change much from that seen during childhood and adolescence. Adult height is far below the third centile, with arm spans exceeding stature by at least 9 cm.

  6. Joubert syndrome with bilateral polymicrogyria: clinical and neuropathological findings in two brothers.

    PubMed

    Giordano, L; Vignoli, A; Pinelli, L; Brancati, F; Accorsi, P; Faravelli, F; Gasparotti, R; Granata, T; Giaccone, G; Inverardi, F; Frassoni, C; Dallapiccola, B; Valente, E M; Spreafico, R

    2009-07-01

    Joubert syndrome (JS) is characterized by hypotonia, ataxia, developmental delay, and a typical neuroimaging finding, the so-called "molar tooth sign" (MTS). The association of MTS and polymicrogyria (PMG) has been reported as a distinct JS-related disorder (JSRD). So far, five patients have been reported with this phenotype, only two of them being siblings. We report on one additional family, describing a living child with JS and PMG, and the corresponding neuropathological picture in the aborted brother. No mutations were detected in the AHI1 gene, the only so far associated with the JS + PMG phenotype. Moreover, linkage analysis allowed excluding all known gene loci, suggesting further genetic heterogeneity.

  7. Klinefelter's syndrome in nontwin brothers and maternal XX/XXX mosaicism.

    PubMed

    Lodi, A; Monti, D; Gaspari, G; Ravaglia, G; Guadagni, C; Businello, M; Lamedica, R; Lenzi, S

    1979-01-01

    A case of two nontwin brothers, 19 and 17 years old, who had both Klinefelter's syndrome with a chromosomal mosaicism 46 XY/47 XXY, is reported here. The analysis of their mother's karyotype revealed a 46 XX/47 XXX mosaicism. It is hypothesized that the presence of an extra X chromosome in all three subjects could depend on the transmission of two X chromosomes from the mother to the sons or, less likely, on an increased liability to nondisjunction of the X chromosomes during one of the early mitotic divisions in the zygotes.

  8. Sisters Helping Sisters.

    ERIC Educational Resources Information Center

    Wright, Madeleine E.

    This book is a comprehensive guide to the philosophy, organization, and management of a mentoring program for African American girls. It is based on a program sponsored by the Wheeler Avenue Baptist Church in Houston (Texas). This program matches between 25 and 50 young women with Christian women mentors. The program emphasizes Christian values,…

  9. Sampling Operations on Big Data

    DTIC Science & Technology

    2015-11-29

    Sampling Operations on Big Data Vijay Gadepally, Taylor Herr, Luke Johnson, Lauren Milechin, Maja Milosavljevic, Benjamin A. Miller Lincoln...ll.mit.edu Abstract—The 3Vs - Volume, Velocity and Variety - of Big Data continues to be a large challenge for systems and algorithms designed to store... big data in Section II, followed by a description of the analytic environment D4M in Section III. We then describe the types of sampling methods and

  10. Living kidney transplantation between brothers with unrecognized renal amyloidosis as the first manifestation of familial Mediterranean fever: a case report.

    PubMed

    Peces, Ramón; Afonso, Sara; Peces, Carlos; Nevado, Julián; Selgas, Rafael

    2017-08-31

    Familial Mediterranean fever is an autosomal recessive disease characterized by recurrent episodes of fever and polyserositis and by the onset of reactive amyloid-associated amyloidosis. Amyloidosis due to familial Mediterranean fever can lead to end-stage renal disease, culminating in kidney transplantation for some patients. In this study, we report the clinical outcome of two brothers with familial Mediterranean fever who were the inadvertent donor and recipient, respectively, of a kidney. Subsequently, they were diagnosed with renal amyloidosis secondary to familial Mediterranean fever and were successfully treated with anakinra and colchicine. Two brothers with familial Mediterranean fever and renal amyloidosis were the inadvertent donor and recipient, respectively, of a kidney. The recipient had presented recurrent acute febrile episodes of familial Mediterranean fever, developed nephrotic syndrome secondary to amyloidosis and needed bilateral nephrectomy and chronic dialysis. His elder brother, in apparent good health, donated his left kidney to his brother. Immediately after the kidney transplantation, both the donor and recipient presented massive proteinuria, impaired renal function and elevated serum amyloid A levels. Biopsies of the brothers' kidneys showed amyloidosis. Genetic studies thereafter revealed a homozygous variant for the MEFV gene (NM_000243.2.c.2082G > A; p.M694I) in both brothers. At this point, both the donor and recipient were treated with colchicine and anakinra, resulting in improved renal function, decreased proteinuria, undetectable serum amyloid A levels and stable renal function at 62 months of follow-up and no major adverse effects. In familial Mediterranean fever, analyses of the MEFV gene should be performed in potential live kidney donors from a direct family member (either between siblings or between parents and children). In addition, genetic studies are required when consanguinity is suspected between members involved in

  11. Chromosome orientation fluorescence in situ hybridization (CO-FISH) to study sister chromatid segregation in vivo

    PubMed Central

    Falconer, Ester; Chavez, Elizabeth; Henderson, Alexander; Lansdorp, Peter M.

    2013-01-01

    Previously, assays for sister chromatid segregation patterns relied on incorporation of BrdU and indirect methods to infer segregation patterns after two cell divisions. Here we describe a method to differentially label sister chromatids of murine cells and directly assay sister chromatid segregation patterns following one cell division in vitro and in vivo by adaptation of the well-established CO-FISH (chromosome orientation fluorescent in situ hybridization) technique. 5-bromo-2′-deoxyuridine (BrdU) is incorporated into newly-formed DNA strands, followed by photolysis and exonuclease digestion to create single-stranded sister chromatids containing parental template DNA only. Such single-stranded sister chromatids are differentially labeled using unidirectional probes to major satellite sequences coupled to fluorescent markers. Differentially-labeled sister chromatids in post-mitotic cells are visualized using fluorescence microscopy and sister chromatid segregation patterns can be directly assayed after one cell division. This procedure requires four days for in vivo mouse tissues, and two days for in vitro cultured cells. PMID:20595964

  12. Narrative research on mental health recovery: two sister paradigms.

    PubMed

    Spector-Mersel, Gabriela; Knaifel, Evgeny

    2017-06-24

    Despite the breadth of narrative studies on individuals with severe mental illness, the suitability of narrative inquiry to exploring mental health recovery (MHR) has not been examined. (1) Examining the appropriateness of narrative inquiry to studying MHR; (2) assessing the extent to which narrative studies on MHR conform to the unique features of narrative research, as a distinctive form of qualitative inquiry. Review of empirical, theoretical and methodological literature on recovery and narrative inquiry. Considering the perspectives of recovery and narrative as paradigms, the similarity between their ontology and epistemology is shown, evident in 10 common emphases: meaning, identity, change and development, agency, holism, culture, uniqueness, context, language and giving voice. The resemblance between these "sister" paradigms makes narrative methodology especially fruitful for accessing the experiences of individuals in recovery. Reviewing narrative studies on MHR suggests that, currently, narrative research's uniqueness, centered on the holistic principle, is blurred on the philosophical, methodological and textual levels. Well-established narrative research has major implications for practice and policy in recovery-oriented mental health care. The narrative inquiry paradigm offers a possible path to enhancing the distinctive virtues of this research, realizing its potential in understanding and promoting MHR.

  13. Detection of sister chromatid exchanges induced by volatile genotoxicants

    SciTech Connect

    Tucker, J.D.; Xu, J.; Stewart, J.; Baciu, P.C.; Ong, T.M.

    1986-01-01

    To test the recently developed method of exposing cells to volatile compounds, phytohemagglutinin-stimulated human peripheral lymphocyte cultures were exposed to gaseous methyl bromide, ethylene oxide, and propylene oxide, as well as diesel exhaust. The cultures were placed in sterile dialysis tubing and inserted into enclosed flasks containing additional culture medium. The test compounds (in gaseous state) were diluted with air and bubbled through the flasks for various lengths of time. The cells were then washed and incubated for a total of 75 h. The harvest was performed according to established procedures, and second-division cells were scored for induction of sister chromatid exchanges (SCEs). The SCE frequency was more than doubled in the cultures treated with ethylene oxide and propylene oxide; methyl bromide also induced SCEs. Cultures treated with diesel exhaust showed an increase in the SCE frequency in cells from two of four donors tested. These results further substantiate the use of this method for detecting the induction of SCEs by airborne genotoxins.

  14. The Bacterial Nucleoid: Nature, Dynamics and Sister Segregation

    PubMed Central

    Kleckner, Nancy; Fisher, Jay K.; Stouf, Mathieu; White, Martin A.; Bates, David; Witz, Guillaume

    2014-01-01

    Recent studies reveal that the bacterial nucleoid has a defined, self-adherent shape and an underlying longitudinal organization and comprises a viscoelastic matrix. Within this shape, mobility is enhanced by ATP-dependent processes and individual loci can undergo ballistic off-equilibrium movements. In E.coli, two global dynamic nucleoid behaviors emerge pointing to nucleoid-wide accumulation and relief of internal stress. Sister segregation begins with local splitting of individual loci, which is delayed at origin, terminus and specialized interstitial snap regions. Globally, as studied in several systems, segregation is a multi-step process in which internal nucleoid state plays critical roles that involve both compaction and expansion. The origin and terminus regions undergo specialized programs partially driven by complex ATP burning mechanisms such as a ParAB Brownian ratchet and a septum-associated FtsK motor. These recent findings reveal strong, direct parallels among events in different systems and between bacterial nucleoids and mammalian chromosomes with respect to physical properties, internal organization and dynamic behaviors. PMID:25460806

  15. Chloroplast phylogenomics indicates that Ginkgo biloba is sister to cycads.

    PubMed

    Wu, Chung-Shien; Chaw, Shu-Miaw; Huang, Ya-Yi

    2013-01-01

    Molecular phylogenetic studies have not yet reached a consensus on the placement of Ginkgoales, which is represented by the only living species, Ginkgo biloba (common name: ginkgo). At least six discrepant placements of ginkgo have been proposed. This study aimed to use the chloroplast phylogenomic approach to examine possible factors that lead to such disagreeing placements. We found the sequence types used in the analyses as the most critical factor in the conflicting placements of ginkgo. In addition, the placement of ginkgo varied in the trees inferred from nucleotide (NU) sequences, which notably depended on breadth of taxon sampling, tree-building methods, codon positions, positions of Gnetopsida (common name: gnetophytes), and including or excluding gnetophytes in data sets. In contrast, the trees inferred from amino acid (AA) sequences congruently supported the monophyly of a ginkgo and Cycadales (common name: cycads) clade, regardless of which factors were examined. Our site-stripping analysis further revealed that the high substitution saturation of NU sequences mainly derived from the third codon positions and contributed to the variable placements of ginkgo. In summary, the factors we surveyed did not affect results inferred from analyses of AA sequences. Congruent topologies in our AA trees give more confidence in supporting the ginkgo-cycad sister-group hypothesis.

  16. Newly discovered sister lineage sheds light on early ant evolution

    PubMed Central

    Rabeling, Christian; Brown, Jeremy M.; Verhaagh, Manfred

    2008-01-01

    Ants are the world's most conspicuous and important eusocial insects and their diversity, abundance, and extreme behavioral specializations make them a model system for several disciplines within the biological sciences. Here, we report the discovery of a new ant that appears to represent the sister lineage to all extant ants (Hymenoptera: Formicidae). The phylogenetic position of this cryptic predator from the soils of the Amazon rainforest was inferred from several nuclear genes, sequenced from a single leg. Martialis heureka (gen. et sp. nov.) also constitutes the sole representative of a new, morphologically distinct subfamily of ants, the Martialinae (subfam. nov.). Our analyses have reduced the likelihood of long-branch attraction artifacts that have troubled previous phylogenetic studies of early-diverging ants and therefore solidify the emerging view that the most basal extant ant lineages are cryptic, hypogaeic foragers. On the basis of morphological and phylogenetic evidence we suggest that these specialized subterranean predators are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant diversification and have persisted in ecologically stable environments like tropical soils over great spans of time. PMID:18794530

  17. Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.

    PubMed

    Ait Saada, Anissia; Teixeira-Silva, Ana; Iraqui, Ismail; Costes, Audrey; Hardy, Julien; Paoletti, Giulia; Fréon, Karine; Lambert, Sarah A E

    2017-05-04

    Replication stress and mitotic abnormalities are key features of cancer cells. Temporarily paused forks are stabilized by the intra-S phase checkpoint and protected by the association of Rad51, which prevents Mre11-dependent resection. However, if a fork becomes dysfunctional and cannot resume, this terminally arrested fork is rescued by a converging fork to avoid unreplicated parental DNA during mitosis. Alternatively, dysfunctional forks are restarted by homologous recombination. Using fission yeast, we report that Rad52 and the DNA binding activity of Rad51, but not its strand-exchange activity, act to protect terminally arrested forks from unrestrained Exo1-nucleolytic activity. In the absence of recombination proteins, large ssDNA gaps, up to 3 kb long, occur behind terminally arrested forks, preventing efficient fork merging and leading to mitotic sister chromatid bridging. Thus, Rad52 and Rad51 prevent temporarily and terminally arrested forks from degrading and, despite the availability of converging forks, converting to anaphase bridges causing aneuploidy and cell death. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Mars' atmosphere: The sister planet, our statistical twin

    NASA Astrophysics Data System (ADS)

    Chen, Wilbur; Lovejoy, Shaun; Muller, Jan-Peter

    2016-10-01

    Satellite-based Martian reanalyses have allowed unprecedented comparisons between our atmosphere and that of our sister planet, underlining various similarities and differences in their respective dynamics. Yet by focusing on large scale structures and deterministic mechanisms they have improved our understanding of the dynamics only over fairly narrow ranges of (near) planetary scales. However, the Reynolds numbers of the flows on both planets are larger than 1011 and dissipation only occurs at centimetric (Mars) or millimetric scales (Earth) so that over most of their scale ranges, the dynamics are fully turbulent. In this paper, we therefore examine the high-level, statistical, turbulent laws for the temperature, horizontal wind, and surface pressure, finding that Earth and Mars have virtually identical statistical exponents so that their statistics are very similar over wide ranges. Therefore, it would seem that with the exception of certain aspects of the largest scales (such as the role of dust in atmospheric heating on Mars, or of water in its various phases on Earth), that the nonlinear dynamics are very similar. We argue that this is a prediction of the classical laws of turbulence when extended to planetary scales and that it supports our use of turbulent laws on both planetary atmospheres.

  19. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.

    PubMed

    Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

    2010-03-04

    The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier.

  20. Sister chromatid exchanges in rotogravure printing plant workers.

    PubMed

    Hammer, K D; Mayer, N; Pfeiffer, E H

    1998-03-01

    The individual burden of inhaled ambient-air toluene and its link to genotoxic phenomena in exposed printing workers. The influence of toluene on sister chromatid exchange (SCE) was investigated by monitoring of the individual toluene burden of 42 exposed printing workers. Therefore, the urinary hippuric acid (HA) excretion was measured directly after the work shift. The results were compared with those recorded for a control group consisting of 45 blood donors. SCE frequencies were determined from peripheral lymphocytes for both groups. The median HA excretion of the exposed and nonexposed groups amounted to 1.94 and 0.45 g/g creatinine, respectively. For both groups, different SCE rates were detected: 10.13 and 6.84 counts/lymphocyte for exposed and nonexposed persons, respectively. The independence of the measured values proved to be significant at a high confidence level (P = 0.000) for both groups. The influences of smoking and alcohol consumption on SCE as well as on HA values could be clearly separated from those induced by toluene. The results of our study indicate a strong relationship between the individual toluene burden and the genotoxic risk of the exposed persons. Since toluene was used for dilution of the letter-press ink, the influence of ink mist on the genotoxic effects could not be completely excluded.

  1. Sororin actively maintains sister chromatid cohesion.

    PubMed

    Ladurner, Rene; Kreidl, Emanuel; Ivanov, Miroslav P; Ekker, Heinz; Idarraga-Amado, Maria Helena; Busslinger, Georg A; Wutz, Gordana; Cisneros, David A; Peters, Jan-Michael

    2016-03-15

    Cohesion between sister chromatids is established during DNA replication but needs to be maintained to enable proper chromosome-spindle attachments in mitosis or meiosis. Cohesion is mediated by cohesin, but also depends on cohesin acetylation and sororin. Sororin contributes to cohesion by stabilizing cohesin on DNA. Sororin achieves this by inhibiting WAPL, which otherwise releases cohesin from DNA and destroys cohesion. Here we describe mouse models which enable the controlled depletion of sororin by gene deletion or auxin-induced degradation. We show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation. We further show that the acetyltransferases ESCO1 and ESCO2 are essential for stabilizing cohesin on chromatin, that their only function in this process is to acetylate cohesin's SMC3 subunit, and that DNA replication is also required for stable cohesin-chromatin interactions. Unexpectedly, we find that sororin interacts dynamically with the cohesin complexes it stabilizes. This implies that sororin recruitment to cohesin does not depend on the DNA replication machinery or process itself, but on a property that cohesin acquires during cohesion establishment.

  2. Two sisters in the same dress: Heliconius cryptic species

    PubMed Central

    2008-01-01

    Background Sister species divergence and reproductive isolation commonly results from ecological adaptation. In mimetic Heliconius butterflies, shifts in colour pattern contribute to pre- and post-mating reproductive isolation and are commonly correlated with speciation. Closely related mimetic species are therefore not expected, as they should lack several important sources of reproductive isolation. Results Here we present phenotypic, behavioral and genetic evidence for the coexistence of two sympatric 'cryptic' species near Florencia in the eastern Andes of Colombia that share the same orange rayed colour pattern. These represent H. melpomene malleti and a novel taxon in the H. cydno group, here designated as novel race of Heliconius timareta, Heliconius timareta florencia. No-choice mating experiments show that these sympatric forms have strong assortative mating (≈96%) despite great similarity in colour pattern, implying enhanced divergence in pheromonal signals. Conclusion We hypothesize that these species might have resulted from recent convergence in colour pattern, perhaps facilitated by hybrid introgression of wing pattern genes. PMID:19040737

  3. Familial orthostatic tremor and essential tremor in two young brothers: A rare entity.

    PubMed

    Bhattacharyya, Kalyan B; Das, D

    2013-04-01

    Orthostatic tremor (OT), is usually a disease of old age and is characterized by quivering movements of the legs during quiet standing or in the state of isometric contraction in the lower limbs. This is relieved on walking or on lying down. It is diagnosed by surface electromyography, particularly over the quadriceps femoris muscles which shows a distinctive frequency of 13 to 18 Hz on standing. Some investigators consider it as a variant of essential tremor (ET) and the two conditions often co-exist. The disease is usually non-familial. Two brothers presented with tremor in the lower limbs on standing and on the outstretched hands without any family history. Subsequently, they were proved to be suffering from OT and ET by clinical examination and surface EMG. Simultaneous occurrence of OT and ET in two young brothers without any family history in the previous generation has not been described before and they also appeared at a much earlier age than what is described in the literature.

  4. How Big is Earth?

    NASA Astrophysics Data System (ADS)

    Thurber, Bonnie B.

    2015-08-01

    How Big is Earth celebrates the Year of Light. Using only the sunlight striking the Earth and a wooden dowel, students meet each other and then measure the circumference of the earth. Eratosthenes did it over 2,000 years ago. In Cosmos, Carl Sagan shared the process by which Eratosthenes measured the angle of the shadow cast at local noon when sunlight strikes a stick positioned perpendicular to the ground. By comparing his measurement to another made a distance away, Eratosthenes was able to calculate the circumference of the earth. How Big is Earth provides an online learning environment where students do science the same way Eratosthenes did. A notable project in which this was done was The Eratosthenes Project, conducted in 2005 as part of the World Year of Physics; in fact, we will be drawing on the teacher's guide developed by that project.How Big Is Earth? expands on the Eratosthenes project by providing an online learning environment provided by the iCollaboratory, www.icollaboratory.org, where teachers and students from Sweden, China, Nepal, Russia, Morocco, and the United States collaborate, share data, and reflect on their learning of science and astronomy. They are sharing their information and discussing their ideas/brainstorming the solutions in a discussion forum. There is an ongoing database of student measurements and another database to collect data on both teacher and student learning from surveys, discussions, and self-reflection done online.We will share our research about the kinds of learning that takes place only in global collaborations.The entrance address for the iCollaboratory is http://www.icollaboratory.org.

  5. The geography and ecology of plant speciation: range overlap and niche divergence in sister species

    PubMed Central

    Anacker, Brian L.; Strauss, Sharon Y.

    2014-01-01

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister–non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities

  6. Sisters of pregnant teens at risk of unwanted pregnancy, CDC says.

    PubMed

    1985-06-01

    Researchers at the Centers for Disease Control suggest that family planning professionals focus efforts to prevent unwanted pregnancies on the sisters of pregnant teenagers. Dr. Andrew M. Friede states that because sisters of pregnant teenagers can be easily identified, they should be sought out and actively enrolled in family planning programs. To determine if the sisters of pregnant teenagers are a high risk group for unwanted pregnancy, researchers analyzed the pregnancy hisory of 3731 women aged 12-16 in multisister families receiving Aid to Families with Dependent Children (AFDC) in Arkansas from 1978-80. A preliminary analysis revealed that teenagers with pregnant sisters had a relative risk of pregnancy of 1.8 compared with teens without pregnant sisters. Further analysis permitted researchers to examine such factors as race, number of people in the household eligible for AFDC, degree of urbanization, and history of family planning services. They confirmed that a young woman with a pregnant sister was more likely to become pregnant, but they also found that the risk was higher if the pregnant sister was older (2.4 relative risk) than if the pregnant sister was younger (1.3 relative risk). The analysis revealed that blacks were at increased risk (2.8 relative risk) as were members of households with 9 or more persons eligible for AFDC (1.8 relative risk). Friede noted that 20% of black women who are exposed to a pregnant sister may be pregnant by their 17th birthday. He recommended further research to identify other groups at high risk and emphasized that improved understanding of families is needed.

  7. Special Review of Smart Start Expenditures by Save Our Brothers, Inc. (Pittsboro, North Carolina) and Liberty Chapel United Church of Christ (Moncure, North Carolina).

    ERIC Educational Resources Information Center

    North Carolina Office of the State Auditor, Raleigh.

    This report of the Office of the State Auditor in North Carolina details audit findings regarding allegations of misuse of Smart Start funds by Save Our Brothers, Inc. and the Liberty Chapel United Church of Christ. Save Our Brothers, Inc., a nonprofit agency, received two contracts totaling $46,327 from the Chatham County Partnership for Children…

  8. Are stepfathers' education levels associated with the intelligence of their stepsons? A register-based study of Norwegian half-brothers.

    PubMed

    Eriksen, Willy; Sundet, Jon M; Tambs, Kristian

    2013-05-01

    We examined the relationship between the parents' education levels and the adult intelligence of their children in a population-based, nationwide sample of Norwegian half-brothers with different fathers (2,016 pairs of half-brothers). In a family where the mother has two children with different men, the firstborn child usually lives with the younger child's father during a period of their childhood. This makes it possible to study the non-genetic effects of paternal education on children's development. Results showed that the education level of the younger half-brother's father was positively associated with the intelligence score of the older half-brother. The education level of the older half-brother's father was not associated with the intelligence score of the younger half-brother. Firstborn men whose half-brothers' fathers had high levels of education had intelligence scores that were 33% (95% confidence interval: 18-47%) of a standard deviation higher than those of firstborn men whose half-brothers' fathers had low levels of education, after adjustment for the biological fathers' education levels, mothers' education levels, and other background factors. These findings are compatible with the hypothesis that a child's family environment exerts an effect on the cognitive abilities of the child that lasts into adulthood.

  9. Wild female baboons bias their social behaviour towards paternal half-sisters.

    PubMed Central

    Smith, Kerri; Alberts, Susan C; Altmann, Jeanne

    2003-01-01

    Adult female cercopithecines have long been known to bias their social behaviour towards close maternal kin. However, much less is understood about the behaviour of paternal kin, especially in wild populations. Here, we show that wild adult female baboons bias their affiliative behaviour towards their adult paternal half-sisters in the same manner and to the same extent that they bias their behaviour towards adult maternal half-sisters. Females appear to rely heavily on social familiarity as a means of biasing their behaviour towards paternal half-sisters, but may use phenotype matching as well. PMID:12641905

  10. "Big Events" and Networks.

    PubMed

    Friedman, Samuel; Rossi, Diana; Flom, Peter L

    2006-01-01

    Some, but not all, "big events" such as wars, revolutions, socioeconomic transitions, economic collapses, and ecological disasters in recent years seem to lead to large-scale HIV outbreaks (Friedman et al, in press; Hankins et al 2002). This was true of transitions in the USSR, South Africa and Indonesia, for example, but not those in the Philippines or (so far) in Argentina. It has been hypothesized that whether or not HIV outbreaks occur is shaped in part by the nature and extent of changes in the numbers of voluntary or involuntary risk-takers, which itself may be related to the growth of roles such as sex-sellers or drug sellers; the riskiness of the behaviors engaged in by risk-takers; and changes in sexual and injection networks and other "mixing patterns" variables. Each of these potential causal processes, in turn, is shaped by the nature of pre-existing social networks and the patterns and content of normative regulation and communication that happen within these social networks-and on how these social networks and their characteristics are changed by the "big event" in question. We will present ideas about what research is needed to help understand these events and to help guide both indigenous community-based efforts to prevent HIV outbreaks and also to guide those who organize external intervention efforts and aid.

  11. Nursing Needs Big Data and Big Data Needs Nursing.

    PubMed

    Brennan, Patricia Flatley; Bakken, Suzanne

    2015-09-01

    Contemporary big data initiatives in health care will benefit from greater integration with nursing science and nursing practice; in turn, nursing science and nursing practice has much to gain from the data science initiatives. Big data arises secondary to scholarly inquiry (e.g., -omics) and everyday observations like cardiac flow sensors or Twitter feeds. Data science methods that are emerging ensure that these data be leveraged to improve patient care. Big data encompasses data that exceed human comprehension, that exist at a volume unmanageable by standard computer systems, that arrive at a velocity not under the control of the investigator and possess a level of imprecision not found in traditional inquiry. Data science methods are emerging to manage and gain insights from big data. The primary methods included investigation of emerging federal big data initiatives, and exploration of exemplars from nursing informatics research to benchmark where nursing is already poised to participate in the big data revolution. We provide observations and reflections on experiences in the emerging big data initiatives. Existing approaches to large data set analysis provide a necessary but not sufficient foundation for nursing to participate in the big data revolution. Nursing's Social Policy Statement guides a principled, ethical perspective on big data and data science. There are implications for basic and advanced practice clinical nurses in practice, for the nurse scientist who collaborates with data scientists, and for the nurse data scientist. Big data and data science has the potential to provide greater richness in understanding patient phenomena and in tailoring interventional strategies that are personalized to the patient. © 2015 Sigma Theta Tau International.

  12. The Big Read: Case Studies

    ERIC Educational Resources Information Center

    National Endowment for the Arts, 2009

    2009-01-01

    The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

  13. The Rise of Big Data in Neurorehabilitation.

    PubMed

    Faroqi-Shah, Yasmeen

    2016-02-01

    In some fields, Big Data has been instrumental in analyzing, predicting, and influencing human behavior. However, Big Data approaches have so far been less central in speech-language pathology. This article introduces the concept of Big Data and provides examples of Big Data initiatives pertaining to adult neurorehabilitation. It also discusses the potential theoretical and clinical contributions that Big Data can make. The article also recognizes some impediments in building and using Big Data for scientific and clinical inquiry.

  14. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges.

    PubMed

    Maeda, Junko; Yurkon, Charles R; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself.

  15. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges

    PubMed Central

    Maeda, Junko; Yurkon, Charles R.; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A.; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A.

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140

  16. Sister chromatid exchange data and Gram-Charlier series.

    PubMed

    Bowman, K O; Eddings, W; Kastenbaum, M A; Shenton, L R

    1998-07-17

    Bowman et al. [K.O. Bowman, M.A. Kastenbaum, L.R. Shenton, Fitting multi-parameter distributions to SCE data, Mutat. Res., 358 (1996) 15-24.] showed how discrete Pearson and discrete Johnson translation-system distributions may be fitted to sister chromatid exchange (SCE) data presented by Bender et al. [M.A. Bender, R.J. Pearston, R.C. Leonard, B.E. Pyatt, P.C. Gooch, On the distribution of spontaneous SCE in human peripheral blood lymphocytes, Mutat. Res., 281 (1992) 227-232.]. When their performances were measured by the chi-squared test of goodness of fit, these distributions proved to be only moderately better alternatives to the poorly fitting Poisson, binomial, and negative binomial distributions. In this paper, we extend our search for better characterizations of the SCE data by calling upon the Gram-Charlier type B approximation of the negative binomial distribution. We introduce an innovative extension of methods described in a little-known paper by Aitken and Gonin [A.C. Aitken, H.T. Gonin, On fourfold sampling with and without replacement, Proc. R. Soc. Edinburgh, 55 (1934) 114-125.], and show how this leads to fits of the SCE data that, in general, are within acceptable levels of probability. Moreover, we show how a theorem by Cramér [H. Cramér, Mathematical Methods of Statistics, Princeton Univ. Press, 1946.], relating to the scale factor m2/m'1 and its asymptotic distribution, may be used to discriminate between smokers and nonsmokers of the same gender.

  17. On Sister, Where Art Thou? The Galilean Satellites After Galileo

    NASA Astrophysics Data System (ADS)

    McKinnon, W. B.

    2006-12-01

    A rich picture has emerged of the four Galileans in the last decade, but for each moon fundamental questions naturally remain unanswered. I will attempt to review a selection of these whose broader application to planetary and satellite science may prove important. Io's volcanic hyperactivity is well known, and offers clues to Io's tidally heated interior state, but the same effusions obscure much of what happens in the interior. The magmas are hot, but how hot? What is the spatial pattern of tidal heating and how is magma transported? Are models based on upwelling of the Earth's upper mantle sufficient, or must more exotic models, such as porous flow through a non-convecting solid matrix, be invoked? What about the canonical (at least at one time) magma ocean? Are Io's spectacular mountains mere "window dressing" or vital clues to otherwise perplexing interior processes? Moving to the exterior moon, Callisto, the central scientific question for this body is how it acquired its ocean yet managed not to be deeply melted (differentiated)? Ganymede (an honorary sister) is ostensibly deeply differentiated, but the existence (if not persistence) of a strong magnetic dynamo within its iron core is a profound puzzle. At the surface, the relative roles of ice-water volcanism and tectonic resurfacing in creating the grooved and "smooth" terrains that cover 2/3 of the solar system's largest satellite remain debated. The stakes for understanding ice resurfacing elsewhere (Europa, Enceladus) are great. And it is Europa that commands our greatest attention. A decade of research has reached a level of maturity: while researchers may disagree on shell thickness, the consensus is that the ocean exists. With a massive body of liquid water, multiple energy sources proposed, and different paths to provide C and other biogenic elements, the central question is Europa's potential for life. There is no greater question.

  18. Two sisters with Mayer-Rokitansky-Küster-Hauser syndrome and serous adenocarcinoma of the ovary.

    PubMed

    Huepenbecker, Sarah P; Divine, Laura; Chu, Christina S; Mutch, David G

    2017-11-01

    Mayer-Rokitansky-Küster-Hauser syndrome is a rare entity with proposed genetic underpinnings. Ovarian carcinoma has well-described genetic associations and syndromes, although much of the etiology of the disease remains unknown. Two sisters present in the 1970s with primary amenorrhea, 46, XX karyotypes, and absent uteri consistent with MRKH syndrome. In the 2010s, both sisters again present for care. Case 1 presents one sister with stage IIIC serous ovarian adenocarcinoma and negative BRCA panel. Case No 2 presents the other sister with stage IIIC serous ovarian adenocarcinoma and a negative panel for 32 genetic variants associated with ovarian carcinoma. The familial association of two rare diseases and negative genetic workup could point to a new genetic understanding of reproductive structure development and ovarian carcinogenesis.

  19. Radiologic findings of Patterson-Lowry rhizomelic dysplasia in two sisters.

    PubMed

    Damar, Çağrı; Boyunağa, Öznur; Derinkuyu, Betül Emine; Battaloğlu, Nergiz; Ezgü, Fatih Süheyl

    2014-11-01

    We report two sisters who have a rare skeletal abnormality termed Patterson-Lowry rhizomelic dysplasia. The typical findings of these cases on bone survey are isolated shortening and proximal metaphyseal enlargement and cupping of the bilateral humeri. The elder sister also has coxa vara deformity and dysplastic proximal femoral epiphyses on both sides. The younger sister has normal hip joint bones bilaterally, but her proximal femoral epiphyses are smaller than normal. All other bones of the sisters are of normal size and configuration. Our patients are two siblings, and their parents are first degree relatives, suggesting autosomal-recessive (AR) inheritance. The present patients help us to understand the genetic relationships and skeletal variabilities of this rare entity.

  20. Endovascular Repair of Internal Mammary Artery Aneurysms in Two Sisters with SMAD3 Mutation.

    PubMed

    Nevidomskyte, Daiva; Shalhub, Sherene; Aldea, Gabriel S; Byers, Peter H; Schwarze, Ulrike; Murray, Mitzi L; Starnes, Benjamin

    2017-03-07

    True aneurysms of the internal mammary artery are rare and have been described in association with vasculitis or connective tissue disorders. Herein we describe two cases of familial internal mammary artery aneurysms in two sisters with SMAD3 mutation. The older sister presented at the age of 54 with an incidental diagnosis of a multilobed right internal mammary artery aneurysm (IMA) and the younger sister presented several years earlier with a ruptured left IMA aneurysm at the age of 49. Both sisters had Debakey type I aortic dissections prior to the IMA aneurysm presentation. To our knowledge this is the first time IMA aneurysms has been described in siblings with SMAD3 mutation. In our experience endovascular repair is a feasible and safe treatment option. An assessment of the entire arterial tree is recommended in patients diagnosed with SMAD3 mutations.