Science.gov

Sample records for brothers big sisters

  1. Mentoring in Schools: An Impact Study of Big Brothers Big Sisters School-Based Mentoring

    ERIC Educational Resources Information Center

    Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; McMaken, Jennifer

    2011-01-01

    This random assignment impact study of Big Brothers Big Sisters School-Based Mentoring involved 1,139 9- to 16-year-old students in 10 cities nationwide. Youth were randomly assigned to either a treatment group (receiving mentoring) or a control group (receiving no mentoring) and were followed for 1.5 school years. At the end of the first school…

  2. Untapped Potential: Fulfilling the Promise of Big Brothers Big Sisters and the Bigs and Littles They Represent

    ERIC Educational Resources Information Center

    Bridgeland, John M.; Moore, Laura A.

    2010-01-01

    American children represent a great untapped potential in our country. For many young people, choices are limited and the goal of a productive adulthood is a remote one. This report paints a picture of who these children are, shares their insights and reflections about the barriers they face, and offers ways forward for Big Brothers Big Sisters as…

  3. High School Students as Mentors: Findings from the Big Brothers Big Sisters School-Based Mentoring Impact Study

    ERIC Educational Resources Information Center

    Herrera, Carla; Kauh, Tina J.; Cooney, Siobhan M.; Grossman, Jean Baldwin; McMaken, Jennifer

    2008-01-01

    High schools have recently become a popular source of mentors for school-based mentoring (SBM) programs. The high school Bigs program of Big Brothers Big Sisters of America, for example, currently involves close to 50,000 high-school-aged mentors across the country. While the use of these young mentors has several potential advantages, their age…

  4. When Your Brother or Sister Has Cancer

    Cancer.gov

    Tips on what to say to your friends, how to deal with stress, and where to find support – as well as information about cancer and cancer treatments, for young people who have a brother or sister with cancer.

  5. Brothers and Sisters: A Source of Support for Children in School?

    ERIC Educational Resources Information Center

    Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie

    2006-01-01

    Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and sisters becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers…

  6. One sister and brother with mirror image myopic anisometropia.

    PubMed

    Park, Sung Joon; Kim, Joo Yeon; Baek, Seung-Hee; Kim, Eung Suk; Kim, Ungsoo S

    2010-02-01

    We report a case of one sister and brother with mirror image myopic anisometropia. One sister and brother complained visual disturbance. The sister was 10 years 11 months old, and brother was 8 years 4 months old. Full ophthalmic examinations were performed, including slit lamp examination, intraocular pressure, keratometry, anterior chamber depth, axial length, fundus examination and the cycloplegic refraction. The cycloplegic refractive power was -15.50 dpt cyl.+4.50 dpt Ax 85 degrees (right eye), -1.00 dpt cyl.+0.50 dpt Ax 90 degrees (left eye) in the sister; -1.75 dpt cyl.+2.25 dpt Ax 90 degrees (right eye), -9.50 dpt cyl.+4.00 dpt Ax 80 degrees (left eye) in the brother. The co-occurrence of severe myopic anisometropia in a sister and brother is extremely rare. The present case suggests that severe myopic anisometropia may be related by genetic inheritance.

  7. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    ERIC Educational Resources Information Center

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  8. Adult Sibling Relationships with Brothers and Sisters with Severe Disabilities

    ERIC Educational Resources Information Center

    Rossetti, Zach; Hall, Sarah

    2015-01-01

    The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or sister with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…

  9. Freud on Brothers and Sisters: A Neglected Topic

    ERIC Educational Resources Information Center

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  10. Paternity testing in case of brother-sister incest.

    PubMed

    Macan, Marijana; Uvodić, Petra; Botica, Vladimir

    2003-06-01

    We performed a paternity test in a case of incest between brother and sister. DNA from blood samples of the alleged parents and their two children was obtained with Chelex DNA extraction method and quantified with Applied Biosystems QuantiBlot quantitation kit. Polymerase chain reaction (PCR) amplification of DNA samples was performed with AmpFlSTR SGM Plus PCR amplification kit and GenePrint PowerPlex PCR amplification kit. The amplified products were separated and detected by using the Perkin Elmer's ABI PRISM trade mark 310 Genetic Analyser. DNA and data analysis of 17 loci and Amelogenin confirmed the suspicion of brother-sister incest. Since both children had inherited all of the obligate alleles from the alleged father, we could confirm with certainty of 99.999999% that the oldest brother in the family was the biological father of both children. Calculated data showed that even in a case of brother-sister incest, paternity could be proved by the analysis of Amelogenin and 17 DNA loci.

  11. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  12. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  13. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  14. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  15. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  16. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  17. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  18. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  19. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  20. 20 CFR 410.215 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or sister. (a) parent, brother, or sister is entitled to benefits beginning with the month all...

  1. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  2. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  3. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  4. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in...

  5. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; parent, brother... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be determined to have been dependent on the miner if, during the...

  6. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met:...

  7. 20 CFR 410.215 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or sister. (a) parent, brother, or sister is entitled to benefits beginning with the month all...

  8. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  9. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  10. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  11. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  12. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner...

  13. The role of brothers and sisters in the gender development of preschool children.

    PubMed

    Rust, J; Golombok, S; Hines, M; Johnston, K; Golding, J

    2000-12-01

    The study examined whether the sex of older siblings influences the gender role development of younger brothers and sisters of age 3 years. Data on the Pre-School Activities Inventory, a measure of gender role behavior that discriminates within as well as between the sexes, were obtained in a general population study for 527 girls and 582 boys with an older sister, 500 girls and 561 boys with an older brother, and 1665 singleton girls and 1707 singleton boys. It was found that boys with older brothers and girls with older sisters were more sex-typed than same-sex singletons who, in turn, were more sex-typed than children with other-sex siblings. Having an older brother was associated with more masculine and less feminine behavior in both boys and girls, whereas boys with older sisters were more feminine but not less masculine and girls with older sisters were less masculine but not more feminine.

  14. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother, or sister. An individual is entitled to benefits if: (a) Such individual: (1) Is the parent,...

  15. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother, or sister. An individual is entitled to benefits if: (a) Such individual: (1) Is the parent,...

  16. Catholic nursing sisters and brothers and racial justice in mid-20th-century America.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing's work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses' work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of "bearing witness," a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely.

  17. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  18. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  19. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  20. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... for parent, grandchild, brother or sister. 222.40 Section 222.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent,...

  1. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    ERIC Educational Resources Information Center

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  2. "Brothers and Sisters": A Novel Way to Teach Human Resources Management.

    ERIC Educational Resources Information Center

    Bumpus, Minnette

    2000-01-01

    The novel "Brothers and Sisters" by Bebe Moore Campbell was used in a management course to explore human resource management issues, concepts, and theories. The course included prereading and postreading surveys, lecture, book review, and examination. Most of the students (92%) felt the novel was an appropriate way to meet course…

  3. Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and Sisters, and Nonclinical Controls.

    ERIC Educational Resources Information Center

    Madan-Swain, Avi; And Others

    1993-01-01

    Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and sisters (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…

  4. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  5. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  6. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  7. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  8. Catholic Nursing Sisters and Brothers and Racial Justice in Mid-20th-Century America

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224

  9. Perceptions of "Big Sisters" and Their "Little Sisters" Regarding Mentoring Relationships

    ERIC Educational Resources Information Center

    Quarles, Alice; Maldonado, Nancy L.; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    This qualitative study explored the relationships between six Little Sisters (mentees) and their Big Sisters (mentors) to develop an understanding of the perceptions of high-risk adolescent female mentees and their mentors regarding their mentoring relationships. Participants were purposefully selected--those actively involved in a formal…

  10. Big brothers and little sisters? Sex selection and birth order.

    PubMed

    Salmon, Catherine

    2007-09-01

    Should you be allowed to choose the sex of your child? Even before the advent of modern reproductive technologies, people have expressed interest in producing a child of a specific sex, trying everything from herbal treatments to sexual positions that have been claimed to produce a male or female child. Modern technologies such as flow cytometry make this a realistic possibility but what might the consequences be? In India and China, a preference for male offspring has led (via abortion) to a significant sex-ratio imbalance in those populations. Do other countries express strong preferences for male or female offspring? This article will address the possible birth order implications. Will we live in a world of first-born boys and second-born girls?

  11. Birth order and ratio of brothers to sisters in Spanish transsexuals.

    PubMed

    Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio

    2011-06-01

    Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than sisters. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism.

  12. Challenging stereotypes? The older woman in the TV series Brothers & Sisters.

    PubMed

    Oró-Piqueras, Maricel

    2014-12-01

    The TV series, Brothers & Sisters, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series.

  13. Learning English through Social Interaction: The Case of "Big Brother 2006," Finland

    ERIC Educational Resources Information Center

    Kaanta, Leila; Jauni, Heidi; Leppanen, Sirpa; Peuronen, Saija; Paakkinen, Terhi

    2013-01-01

    In line with recent Conversation Analytic work on language learning as situated practice, this article investigates how interactants can create language learning opportunities for themselves and others in and through social interaction. The study shows how the participants of "Big Brother Finland," a reality TV show, whose main…

  14. Adolescent Siblings of Individuals with and without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings about Their Brothers and Sisters

    ERIC Educational Resources Information Center

    Shivers, Carolyn M.; Dykens, Elisabeth M.

    2017-01-01

    Siblings of brothers or sisters with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward…

  15. A resolution recognizing the 100-year anniversary of Big Brothers Big Sisters Southeastern Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2014-12-11

    12/11/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S6698; text as passed Senate: CR S6631) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  16. A brother and sister with breast cancer, BRCA2 mutations and bilateral supernumerary nipples

    PubMed Central

    Coad, Ryan

    2017-01-01

    We describe a 54-year-old man with breast cancer and a BRCA2 mutation who was also found to have bilateral supernumerary nipples. His sister, also with a BRCA2 mutation, was diagnosed with breast cancer in her late forties; she also had bilateral supernumerary nipples. We address the significance of breast cancer arising in breast tissue underlying supernumerary nipples; the known association between supernumerary nipples and genitourinary malignancies/malformations and the possible link between BRCA2 and supernumerary nipple development. We believe that this is the first described case of the latter. We then outline an approach to further management for supernumerary nipple cases. PMID:28361071

  17. Super Mario brothers and sisters: Associations between coplaying video games and sibling conflict and affection.

    PubMed

    Coyne, Sarah M; Jensen, Alexander C; Smith, Nathan J; Erickson, Daniel H

    2016-02-01

    Video games can be played in many different contexts. This study examined associations between coplaying video games between siblings and levels of affection and conflict in the relationship. Participants were 508 adolescents (M age = 16.31 years of age, SD = 1.08) who completed questionnaires on video game use and sibling relationships. Participants were recruited from a large Northwestern city and a moderate city in the Mountain West of the United States. Video games played between siblings were coded by an independent sample to assess levels of physical aggression and prosocial behavior in each game. Playing video games with a sibling was associated with higher levels of sibling affection for both boys and girls, but higher levels of conflict for boys only. Playing a violent video game with a brother was associated with lower levels of conflict in the sibling relationship, whereas playing a prosocial video game was not related to any sibling outcome. The value of video games in sibling relationships will be discussed, with a focus on the type of game and the sex of the adolescent.

  18. Big brother.

    PubMed

    Cross, M

    1993-04-15

    Both purchasers and providers will need to change the way they hold patient records on computer, or they could find themselves in breach of the law. Michael Cross examines a report by the Data Protection Registrar.

  19. "Big data" versus "big brother": on the appropriate use of large-scale data collections in pediatrics.

    PubMed

    Currie, Janet

    2013-04-01

    Discussions of "big data" in medicine often revolve around gene sequencing and biosamples. It is perhaps less recognized that administrative data in the form of vital records, hospital discharge abstracts, insurance claims, and other routinely collected data also offer the potential for using information from hundreds of thousands, if not millions, of people to answer important questions. However, the increasing ease with which such data may be used and reused has increased concerns about privacy and informed consent. Addressing these concerns without creating insurmountable barriers to the use of such data for research is essential if we are to avoid a "missed opportunity" in pediatrics research.

  20. Big Brother Not Needed.

    ERIC Educational Resources Information Center

    Heinen, Edward

    1983-01-01

    Cites the recent United States State Department's labeling of recent Canadian films--one on nuclear war and two on acid rain--as political propaganda as a sign of the need to review the nature of propaganda. Suggests that teaching students to intelligently evaluate propaganda is preferable to submitting to government dictum. (MM)

  1. Comparison between high-resolution climate simulations using single- and double-nesting approaches within the Big-Brother experimental protocol

    NASA Astrophysics Data System (ADS)

    Matte, Dominic; Laprise, René; Thériault, Julie Mireille

    2016-12-01

    Regional climate models (RCM) are widely used to downscale global climate models' (GCMs) simulations. As the resolution of RCM increases faster than that of GCM used for climate-change projections till the end of this century, the resolution jump will become an issue. Cascade with multiple nesting offers an approach to reach high resolution while keeping reasonable computational cost. Few studies have addressed whether the best results are obtained with the single- or multiple-nesting approaches. In this study the results obtained with single and double nesting are compared within the idealised "perfect model" framework of the Big-Brother Experiment. This method consists in first realizing a simulation, nicknamed the Big-Brother (BB) simulation, on a relatively large domain at the desired resolution, to serve as reference dataset. The BB results are then processed by a low-pass filter to emulate a coarse-resolution dataset to be used as LBC to drive further simulations, nicknamed the Little-Brother (LB) simulations, using an identical model formulation and resolution as the BB simulation. For the single nesting, the LB simulations are directly simulated, while for the double nesting a surrogate intermediate-resolution simulation is used. The study of the time-mean (stationary) component shows that little difference is noted between the single- and double-nesting approaches. The time-deviation (transient-eddy) component, however, shows important differences. The double-nesting approach weakly degrades the large scales but allows a significant reduction of the required domain size to allow adequate spin-up of fine-scale features. This results in an important saving in the computational cost.

  2. Bah's Baby Brother Is Born.

    ERIC Educational Resources Information Center

    Tapahonso, Luci

    This illustrated story, written for Native American children, stresses the importance of not drinking alcohol and taking care of oneself during pregnancy. The story centers on Bah, a young Native American girl whose mother is going to have a baby. Bah is very excited about getting a baby brother or sister and wants the baby to be healthy and…

  3. My Brother

    NASA Astrophysics Data System (ADS)

    Kwartin, Ina

    I was lucky. I was born younger. My older brother has been with me my whole life. He was an altogether special person, very noble and generous, a foreigner to things kitsch and to banality. When I was a child, he spent a great deal of time with me. During that difficult period parents had to spend almost the whole day at work, and in many households children were l to themselves. At my home I had my brother, who was never a "babysitter" to me and never gave the impression that I was a burden to him. Being together was interesting…

  4. Teletext--Prestel's Big Brother.

    ERIC Educational Resources Information Center

    Hughes, Geoffrey

    Prestel, Oracle, and Ceefax are telephone based video text systems currently in use in Great Britain. Rather than being considered as competitors, they should be viewed as complementary media with separate functions based on their differences. All use home television sets to receive information in print, and all broadcast on spare TV lines in the…

  5. Sisters and Brothers, Brothers and Sisters in the Family Affected by Traumatic Brain Injury.

    ERIC Educational Resources Information Center

    Pieper, Betty

    This report is based on a qualitative research study which utilized a nominal group process to identify major life stressors for parents of children with traumatic brain injuries (TBI). It focuses first on effects of TBI on siblings and then on effective interventions. The first section uses quotes from participating parents to identify their…

  6. Babbitt's Brothers & Sisters: Raising Ethical Issues in Business Literature.

    ERIC Educational Resources Information Center

    Halpern, Jeanne W.

    A college-level course in business literature is an ideal place to raise and discuss ethical issues. To be successful, a teacher of this course must engage student interest, help the students articulate and understand their own ethical attitudes, clarify the stance and artistry of the author, and refine student responses to ethical questions. When…

  7. Siblings of Oedipus: Brothers and Sisters of Incest Victims.

    ERIC Educational Resources Information Center

    de Young, Mary

    1981-01-01

    Investigates the roles and problems of siblings of incest victims, describes the dynamics of the incestuous family, and identifies some behavior problems of children whose siblings were incest victims. Data from two siblings' lives are presented to illustrate points. (Author/DB)

  8. Ectrodactyly in sisters and half sisters.

    PubMed Central

    Mufti, M H; Wood, S K

    1987-01-01

    An extended family is described in which four sisters and half sisters presented with ectrodactyly. Two of the sisters had associated agenesis of the tibiae. The paper describes the malformations and discusses the management and possible genetic inheritance involved. An autosomal recessive gene seems likely to be the mode of inheritance. Images PMID:3585937

  9. Big Brother Is Not Watching You Act

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-15

    03/20/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. Brothers of the Christian Schools

    ERIC Educational Resources Information Center

    Salm, Luke

    2007-01-01

    The Brothers of the Christian Schools, popularly known in the United States as Christian Brothers, have made numerous significant contributions to the development of Catholic education. Building and staffing schools, colleges, and orphanages, producing textbooks and catechetical materials, advocating for the poor, and creating new models of…

  11. Where are Sedna's Sisters?

    NASA Astrophysics Data System (ADS)

    Bartlett, D. F.

    2005-05-01

    Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

  12. 75 FR 71458 - Warner Brothers Entertainment, Inc., Warner Brothers Theatrical Enterprises, Including Workers of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... Brothers Consumer Products, Inc., Warner Brothers International Television Distribution, Inc., Warner... Facilities, and Warner Brothers Entertainment Company, Burbank, CA; Amended Certification Regarding... published in the Federal Register on November 17, 2009 (74 FR 59254). At the request of a company...

  13. Goddard Welcomes SISTER

    NASA Video Gallery

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  14. 75 FR 80669 - Wright Brothers Day, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Proclamation 8617--Wright Brothers Day, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register... President ] Proclamation 8617 of December 17, 2010 Wright Brothers Day, 2010 By the President of the United... conquered the age-old dream of manned flight. That day, the two brothers from Dayton, Ohio, could...

  15. 77 FR 75503 - Wright Brothers Day, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... December 20, 2012 Part II The President Proclamation 8918--Wright Brothers Day, 2012 #0; #0; #0... Brothers Day, 2012 By the President of the United States of America A Proclamation After years of research... changed our way of life. On Wright Brothers Day, we reflect on their astonishing feat and celebrate...

  16. 78 FR 76969 - Wright Brothers Day, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... December 19, 2013 Part III The President Proclamation 9071--Wright Brothers Day, 2013 #0; #0; #0... Brothers Day, 2013 By the President of the United States of America A Proclamation On December 17, 1903... boundaries of human imagination and paving the way for over a century of innovation. On Wright Brothers...

  17. THREE SISTERS WILDERNESS, OREGON.

    USGS Publications Warehouse

    MacLeod, Norman S.; Causey, J. Douglas

    1984-01-01

    A mineral survey of the Three Sisters Wilderness, Oregon indicated little promise for the occcurrence of metallic mineral resources. Block pumice suitable for commercial uses occurs at an undeveloped claim at Rock Mesa in the wilderness, but numerous other sources occur outside the wilderness closer to markets. A broad area centered around South Sister volcano is among the most favorable targets for geothermal resources in the Oregon Cascade Range, based on the very young age and large volume of silicic volcanic rocks that occur in this area. Deep exploration holes could be drilled in areas outside the wilderness south of South Sister to provide data on the subsurface thermal and hydrologic regimes in the southern part of the area most likely to contain geothermal resources.

  18. Scott Brothers Windows and Doors Information Sheet

    EPA Pesticide Factsheets

    Scott Brothers Windows and Doors (the Company) is located in Bridgeville, Pennsylvania. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Pittsburgh, Pennsylvania.

  19. Quantitative and theoretical analyses of the relation between older brothers and homosexuality in men.

    PubMed

    Blanchard, Ray

    2004-09-21

    Meta-analysis of aggregate data from 14 samples representing 10,143 male subjects shows that homosexuality in human males is predicted by higher numbers of older brothers, but not by higher numbers of older sisters, younger brothers, or younger sisters. The relation between number of older brothers and sexual orientation holds only for males. This phenomenon has therefore been called the fraternal birth order effect. Research on birth order, birth weight, and sexual orientation suggests that the developmental pathway to homosexuality initiated by older brothers operates during prenatal life. Calculations assuming a causal relation between older brothers and sexual orientation have estimated the proportion of homosexual men who owe their sexual orientation to fraternal birth order at 15% in one study and 29% in another. The maternal immune hypothesis proposes that the fraternal birth order effect reflects the progressive immunization of some mothers to male-specific antigens by each succeeding male fetus and the increasing effects of such immunization on sexual differentiation of the brain in each succeeding male fetus. There are at least three possible mechanisms by which the mother's immune response could influence the fetus: the transfer of anti-male antibodies across the placenta from the maternal into the fetal compartment, the transfer of maternal cytokines across the placenta, and maternal immune reactions affecting the placenta itself. This hypothesis is consistent with recent studies showing that the quantity of fetal cells that enter the maternal circulation is greater than previously thought, and that the number of male-specific proteins encoded by Y-chromosome genes is greater than previously thought.

  20. 76 FR 79019 - Wright Brothers Day, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... December 20, 2011 Part III The President Proclamation 8767--Wright Brothers Day, 2011 Memorandum of... ] Proclamation 8767 of December 15, 2011 Wright Brothers Day, 2011 By the President of the United States of... this day, guide our jetliners to every corner of the world and our spacecraft to the farthest...

  1. "My Brother Likes Meeting New People, but Don't Ask Him Any Direct Questions": Involving Adults with Autism plus Learning Disability in a Qualitative Research Project

    ERIC Educational Resources Information Center

    Tozer, Rosemary; Atkin, Karl; Wenham, Aniela

    2014-01-01

    Adult siblings of people with autism and a learning disability have hitherto been largely overlooked by research, policy and practice in the UK. As part of a qualitative study focussing on adult siblings, we met twelve people with autism plus severe learning disability with their brother or sister. Individually tailored resources were used to make…

  2. Pituitary cretinism in two sisters.

    PubMed Central

    Kohno, H; Watanabe, N; Ootsuka, M; Kajiwara, M; Gohya, N

    1980-01-01

    Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after administration of thyrotropin-releasing hormone. We conclude that cretinism in these 2 sisters was due to TSH deficiency. This is the second report of 'familial' pituitary cretinism (TSH-deficient congenital hypothyroidism). PMID:7436542

  3. Examining Big Brother's Purpose for Using Electronic Performance Monitoring

    ERIC Educational Resources Information Center

    Bartels, Lynn K.; Nordstrom, Cynthia R.

    2012-01-01

    We examined whether the reason offered for electronic performance monitoring (EPM) influenced participants' performance, stress, motivation, and satisfaction. Participants performed a data-entry task in one of five experimental conditions. In one condition, participants were not electronically monitored. In the remaining conditions, participants…

  4. Telemonitoring in heart failure: Big Brother watching over you.

    PubMed

    Dierckx, R; Pellicori, P; Cleland, J G F; Clark, A L

    2015-01-01

    Heart failure (HF) is a leading cause of hospitalisations in older people. Several strategies, supported by novel technologies, are now available to monitor patients' health from a distance. Although studies have suggested that remote monitoring may reduce HF hospitalisations and mortality, the study of different patient populations, the use of different monitoring technologies and the use of different endpoints limit the generalisability of the results of the clinical trials reported, so far. In this review, we discuss the existing home monitoring modalities, relevant trials and focus on future directions for telemonitoring.

  5. Big Brother Is Watching: Video Surveillance on Buses

    ERIC Educational Resources Information Center

    Sloggett, Joel

    2009-01-01

    Many school districts in North America have adopted policies to permit cameras on their properties and, when needed, on buses used to transport students. With regard to school buses, the camera is typically a tool for gathering information to monitor behavior or to help investigate a complaint about behavior. If a picture is worth a thousand…

  6. Chromosome segregation: Samurai separation of Siamese sisters.

    PubMed

    Glotzer, M

    1999-07-15

    How do cells ensure that sister chromatids are precisely partitioned in mitosis? New studies on budding yeast have revealed that sister chromatid separation at anaphase requires endoproteolytic cleavage of a protein that maintains the association between sister chromatids.

  7. Small supernumerary marker chromosomes and the nuclear architecture of sperm - a study in a fertile and an infertile brother.

    PubMed

    Karamysheva, Tatyana; Kosyakova, Nadezda; Guediche, Narjes; Liehr, Thomas

    2015-01-01

    Small supernumerary marker chromosomes (sSMC) are found about four times more frequently in subfertile compared to the general population. The reason for this finding is still unclear. However, a connection of interphase architecture and genome function is suggested. And as we found in a previous study the presence of sSMC influences the nuclear architecture of peripheral blood cells and fibroblasts, we hypothesized that sSMC could have similar effects in sperm cells possibly leading to infertility. Here we applied for the first time 3-dimensional interphase fluorescence in situ hybridization (3D-FISH) to characterize the position of an extra-chromosome with respect to its sister- and selected other chromosomes (6, 15, 18, 19, 21, X, and Y) in sperm. Two sSMC carrier brothers with the identical sSMC derived from chromosome 15 were studied. One of the brothers was fertile and the other brother was infertile. Deviations from the normal positioning of chromosomes 21 and Y were seen in both brothers and for chromosomes 19 and X only in the infertile brother. Most striking were high rates of nullisomy and/or disomy for chromosomes 15, including sSMC (15), and 18 exclusively seen in the infertile brother. Overall, further evidence is provided that sSMC influence the nuclear architecture of a cell, including sperm. Further studies are necessary in sperm of fertile and infertile sSMC carriers to elaborate if the detected aneuploidy like that seen in the infertile brother is due to sSMC presence and disturbance of nuclear architecture.

  8. Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome

    PubMed Central

    Liu, D.M.; Torchen, L.C.; Sung, Y.; Paparodis, R.; Legro, R.S.; Grebe, S.K.; Singh, R.J.; Taylor, R.L.; Dunaif, A.

    2014-01-01

    .1 controls, IU/l P = 0.002), AD (1.7 ± 1.4 brothers versus 0.9 ± 1.5 controls, nmol/l, P = 0.02) and ΔAD/ΔT (0.16 ± 0.14 brothers versus 0.08 ± 0.12 controls, P = 0.005) responses were increased in brothers compared with controls. LIMITATIONS, REASONS FOR CAUTION The modest sample size may have limited our ability to observe other possible differences in steroidogenesis between PCOS brothers and control men. WIDER IMPLICATIONS OF THE FINDINGS Decreased ACTH-stimulated Δ17Preg/Δ17Prog and ΔDHEA/ΔAD responses suggested increased adrenal 3β-hydroxysteroid dehydrogenase activity in the brothers. Decreased Δ17Prog/ΔAD and increased ΔAD/ΔT responses to GnRH agonist stimulation suggested increased gonadal 17,20-lyase and decreased gonadal 17β-hydroxysteroid dehydrogenase activity in the brothers. Increased LH and FSH responses to GnRH agonist stimulation suggested neuroendocrine alterations in the regulation of gonadotrophin secretion similar to those in their proband sisters. These changes in PCOS brothers may reflect the impact of PCOS susceptibility genes and/or programming effects of the intrauterine environment. STUDY FUNDING/COMPETING INTEREST(S) This research was supported by P50 HD044405 (A.D.), K12 HD055884 (L.C.T.), U54 HD034449 (A.D., R.S.L.) from the National Institute of Child Health and Development. Some hormone assays were performed at the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core that is supported by U54 HD28934 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Partial support for some of the clinical studies was provided by UL1 RR025741 and UL1 TR000150 (Northwestern University Clinical and Translational Sciences Institute) from the National Center for Research Resources, National Institutes of Health, which is now the National Center for Advancing Translational Sciences. The authors have no conflict of interest to declare. PMID:25336708

  9. When Your Brother or Sister Has Cancer: A Guide for Teens

    MedlinePlus

    ... feel that way right now. When it is dark enough, 80 ➜ Get help when you feel alone. ... patients and their families about emotional and personal matters and helps them make decisions, but does not ...

  10. Brothers, Sisters and Fictive Kin: Communication about Sex among Urban Black Siblings

    ERIC Educational Resources Information Center

    Wallace, Scyatta A.; Hooper, Lisa M.; Persad, Malini

    2014-01-01

    Siblings have been shown to influence youth substance use and violent behavior. However, limited research has examined sibling-influences on sexual activity, particularly among urban Black youth. The current qualitative research was an exploratory study to describe discussions among siblings about sex and sexual health. Individual interviews were…

  11. The Brothers and Sisters Learn To Write: Popular Literacies in Childhood and School Cultures.

    ERIC Educational Resources Information Center

    Dyson, Anne Haas

    Building on the author's groundbreaking work in "Building Superheroes," this book traces the influence of a wide-ranging set of "textual toys" from children's lives--church and hip-hop songs, rap music, movies, TV, traditional jump-rope rhymes, the words of professional sports announcers and radio deejays--upon school learning…

  12. Born to be poor: birthplace and number of brothers and sisters as factors in adult poverty.

    PubMed

    Orshansky, M; Bretz, J S

    1976-01-01

    Household heads who grew up as members of large families and/or as natives of small towns or rural areas tend to have less education and are more likely to be poor than those coming from small families and/or large cities. Data to support these conclusions have been drawn from two independent sources--a special Social Security Administration supplement to the April 1968 Current Population Survey and findings from the Retirement History Study conducted by the Social Security Administration.

  13. Who Are My Sisters and Brothers? Reflections on Understanding and Welcoming Immigrants and Refugees.

    ERIC Educational Resources Information Center

    United States Catholic Conference, Washington, DC.

    The essays in this collection are presented as reflections to accompany an educational guide on the response of the Catholic Christian to immigrants and refugees. The following essays are included: (1) "Refugees Today: Rescue or Containment?" (Richard Ryscavage); (2) "Catholic Church Teachings and Documents Regarding Immigration: Theological…

  14. What We Learn from Our Sisters and Brothers: For Better or for Worse

    ERIC Educational Resources Information Center

    Kramer, Laurie; Conger, Katherine J.

    2009-01-01

    Siblings have considerable influence on one another's development throughout childhood, yet most human development research has neglected sibling socialization. Through this volume, we aim to enhance our understanding of how siblings play formative roles in one another's social and emotional development. We examine the mechanisms by which children…

  15. Mothers' Differential Treatment of Adolescent Siblings: Predicting College Attendance of Sisters versus Brothers

    ERIC Educational Resources Information Center

    Bissell-Havran, Joanna M.; Loken, Eric; McHale, Susan M.

    2012-01-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We…

  16. "You Can Do Nasty Things to Your Brothers and Sisters without a Reason": Siblings' Backstage Behaviour

    ERIC Educational Resources Information Center

    Punch, Samantha

    2008-01-01

    This article contributes to the recent, but still limited, literature on the sociology of sibship. It argues that during childhood the ambivalent love/hate nature of sibship is played out through the sharing of knowledge, time and space. It draws on the work of Goffman to illustrate that children's sibling interactions tend to consist of…

  17. Family-focused prevention with Latinos: What about sisters and brothers?

    PubMed

    Updegraff, Kimberly A; Umaña-Taylor, Adriana J; Rodríguez De Jesús, Sue A; McHale, Susan M; Feinberg, Mark F; Kuo, Sally I-Chun

    2016-08-01

    Using a randomized, intent-to-treat design, this pilot study examined the feasibility and short-term effects of Siblings Are Special (SIBS) with a sample of 54 low-income Latino families (91% Mexican-origin). Participants were older (M = 10.8 years; SD = .46) and younger siblings (M = 8.4 years; SD = 1.13), and their parents (94% biological mothers), who were randomly assigned within school to the intervention (n = 28) or no-attention control (n = 26) condition. The intervention condition included 12 weekly afterschool sessions (90 min each) for sibling pairs and 3 family nights for parents and siblings (2 hr each). SIBS was designed to enhance sibling relationships via 2 primary intervention targets: (a) children’s capacities that underlie positive sibling dynamics, including relationship skills, cognitions, and shared activities; and (b) parenting of siblings, specifically, enhancing positive guidance and involvement and discouraging authoritarian control. Pre- and posttest data were gathered from siblings and parents. Recruitment and implementation data revealed high rates of attendance and completion, and high ratings of parent satisfaction with the program. Further, analyses suggested the program had positive effects of small to modest magnitude on posttest measures of sibling and parent–child relationship quality, parenting of siblings, older siblings’ emotional efficacy, and parents’ depressive symptoms and parenting stress, controlling for pretest levels of all outcomes and family background characteristics. Discussion addresses the feasibility of sibling-focused programs with low-income Latino families and makes recommendations for future research.

  18. Preschool Siblings of Handicapped Children: Interactions with Mothers, Brothers, and Sisters.

    ERIC Educational Resources Information Center

    Lobato, Debra J.; And Others

    1991-01-01

    This study, involving 40 young siblings of either handicapped or nonhandicapped children, found that siblings of handicapped children engaged in more parallel and social play and were more nurturing with their siblings than were control children. Mothers were more likely to deliver commands, directives, and reprimands to siblings of handicapped…

  19. The Role of Gender in Youth Mentoring Relationship Formation and Duration

    ERIC Educational Resources Information Center

    Rhodes, Jean; Lowe, Sarah R.; Litchfield, Leon; Walsh-Samp, Kathy

    2008-01-01

    The role of gender in shaping the course and quality of adult-youth mentoring relationships was examined. The study drew on data from a large, random assignment evaluation of Big Brothers Big Sisters of America (BBSA) programs [Grossman, J. B., & Tierney, J. P. (1998). Does mentoring work? An impact study of the Big Brothers Big Sisters program.…

  20. My Brother's Keeper

    ERIC Educational Resources Information Center

    Obama, Barack

    2014-01-01

    In a White House address, the president announced an initiative to reclaim young boys and men of color. The "My Brother's Keeper" initiative partners with businesses, foundations, and nonprofits to address disparities in education, justice, and employment. President Obama was introduced by Christian, one of a group of students from…

  1. Build Your Own Wright Brothers' Glider

    ERIC Educational Resources Information Center

    Schimmel, Gordon; Hand, Jon; Ellis, Art

    2003-01-01

    A little more than one hundred years ago, Wilbur and Orville Wright began building models of airfoils and testing them in wind tunnels in their search for an efficient wing. Models continue to be used today by aerospace engineers to prove concepts and launch dreams. To celebrate the centennial of the Wright brothers' historic flight, the authors…

  2. Pleural mesothelioma in a couple of brothers

    PubMed Central

    Bianchi, Claudio; Bianchi, Tommaso

    2013-01-01

    Malignant mesotheliomas of the pleura, epithelial type, were observed in two brothers. Both the patients had histories of severe exposure to asbestos, having worked as insulators. The latency periods in the two cases were 26 and 38 years, respectively. Available literature data suggest that mesothelioma occurrence among blood-related people is favored by a genetic predisposition. PMID:24872671

  3. Writing siblings: Alice James and her brothers.

    PubMed

    Hoffman, Anne Golomb

    2015-02-01

    This essay addresses the relationship of writing to embodiment, through representations of bodily sensation and fantasy in the journal of Alice James. It considers Alice James's writing in relation to her two writer brothers, William and Henry, and in light of their father's experiences of impairment and breakdown.

  4. Brotherly Love? The Manipulation of Body Boundaries

    ERIC Educational Resources Information Center

    Beck, Benjamin

    2011-01-01

    This article is about a street-wise boy who is unaware that his younger brother has been using clever manipulation to get him into trouble. Nicholas is a 12-year-old boy whose father was recently given a life sentence for murder. Nicholas is in a boxing league and uses his fighting skills on the streets. Angel is Nicholas' nine-year-old brother…

  5. Two brothers with keratosis follicularis spinulosa decalvans.

    PubMed

    Alfadley, Abdullah; Al Hawsawi, Khalid; Hainau, Bo; Al Aboud, Khalid

    2002-11-01

    Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder affecting both the skin and eyes. There are few reports about this entity. The aim of this report is to describe 2 brothers with progressive scarring alopecia of the scalp, hypotrichosis with follicular prominence of the eyelashes, and extensive keratosis pilaris. The second patient has Down syndrome with palmoplantar keratoderma and partial alopecia of the eyebrows. We also reviewed the literature about this uncommon entity.

  6. Two Sisters with Rett Syndrome. Brief Report.

    ERIC Educational Resources Information Center

    Haenggeli, Charles A.; And Others

    1990-01-01

    Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

  7. A Brief Analysis of Sister Carrie's Character

    ERIC Educational Resources Information Center

    Yu, Hanying

    2010-01-01

    Carrie is always dreaming while the rocking chair is rocking again and again, this is the deep impression on us after we read "Sister Carrie" which is the first novel of Theodore Dreiser. In this novel the protagonist Sister Carrie is a controversial person. This paper tries to analyze the character of Sister Carrie in order to find out…

  8. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor"…

  9. Big Data: Big Confusion? Big Challenges?

    DTIC Science & Technology

    2015-05-01

    12th Annual Acquisition Research Symposium 12th Annual Acquisition Research Symposium Big Data: Big Confusion? Big Challenges? Mary Maureen...currently valid OMB control number. 1. REPORT DATE MAY 2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Big ...Data: Big Confusion? Big Challenges? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK

  10. The Mayo brothers: an American surgical legacy.

    PubMed

    Toledo-Pereyra, Luis H

    2010-10-01

    Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams.

  11. Bram Stoker's brother, the brain surgeon.

    PubMed

    Stiles, Anne

    2013-01-01

    This essay examines the life and work of Sir William Thornley Stoker, 1st Baronet (1845-1912), the eldest brother of Bram Stoker (1847-1912), the author of Dracula (1897). Sir William or "Thornley," as he was commonly known, was one of Ireland's leading physicians. He performed some of the first brain surgeries in Ireland using Sir David Ferrier's maps of the cerebral cortex. From 1879 into the twentieth century, Thornley served as inspector for Ireland under the 1876 Cruelty to Animals Act. In this role, Thornley was responsible for granting licenses to researchers who performed experiments on live animals. Due to his reservations about animal experimentation, Thornley eventually became an advocate for the antivivisection cause, testifying at the second Royal Commission on Vivisection (1906-1912). Thornley also influenced Irish literature, albeit indirectly. Bram Stoker's composition notes for Dracula show that he consulted his older brother about the medical scenes in his novel. Thornley's knowledge of cerebral localization and his animal rights advocacy both surface in Dracula.

  12. Authentic Expression of Edmund Rice Christian Brother Education

    ERIC Educational Resources Information Center

    Vercruysse, Raymond J.

    2007-01-01

    In 1802, Edmund Rice directed the laying of the foundation stone for Mount Sion Monastery and School. After several previous attempts of instructing poor boys in Waterford, this was to be the first permanent home for the Congregation of Christian Brothers. Rice's dream of founding a religious community of brothers was becoming a reality with a…

  13. Two Dutch brothers with Borrone dermato-cardio-skeletal syndrome.

    PubMed

    van Steensel, M A M; Ceulen, R P M; Delhaas, T; de Die-Smulders, C

    2007-06-01

    In 1993, Borrone et al. described two Italian brothers affected by a syndrome of severe acne, mitral valve prolapse, dysmorphic facies, and Scheuermann-like changes of the vertebral column. Since then, no further cases have been reported. Here, we report on two Dutch brothers with many features suggestive of this rare syndrome.

  14. 36 CFR 7.76 - Wright Brothers National Memorial.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Memorial. 7.76 Section 7.76 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.76 Wright Brothers National Memorial. (a) Designated airstrip. Wright Brothers National Memorial Airstrip, located at Kill Devil Hills,...

  15. 36 CFR 7.76 - Wright Brothers National Memorial.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Memorial. 7.76 Section 7.76 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.76 Wright Brothers National Memorial. (a) Designated airstrip. Wright Brothers National Memorial Airstrip, located at Kill Devil Hills,...

  16. Holocentric plant meiosis: first sisters, then homologues.

    PubMed

    Heckmann, Stefan; Schubert, Veit; Houben, Andreas

    2014-01-01

    Meiosis is a crucial process of sexual reproduction by forming haploid gametes from diploid precursor cells. It involves 2 subsequent divisions (meiosis I and meiosis II) after one initial round of DNA replication. Homologous monocentric chromosomes are separated during the first and sister chromatids during the second meiotic division. The faithful segregation of monocentric chromosomes is realized by mono-orientation of fused sister kinetochores at metaphase I and by bi-orientation of sister kinetochores at metaphase II. Conventionally this depends on a 2-step loss of cohesion, along chromosome arms during meiosis I and at sister centromeres during meiosis II.

  17. 78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Sister Bay Marina Fest Fireworks and Ski... intended to restrict vessels from a portion of Sister Bay due to a fireworks display and ski show. This... with the fireworks display and ski show in Sister Bay on August 31, 2013. DATES: This rule is...

  18. Big Society, Big Deal?

    ERIC Educational Resources Information Center

    Thomson, Alastair

    2011-01-01

    Political leaders like to put forward guiding ideas or themes which pull their individual decisions into a broader narrative. For John Major it was Back to Basics, for Tony Blair it was the Third Way and for David Cameron it is the Big Society. While Mr. Blair relied on Lord Giddens to add intellectual weight to his idea, Mr. Cameron's legacy idea…

  19. Neurological and architectural sinuosities: the Niemeyer brothers.

    PubMed

    Cavalcanti, Daniel D; Guasti, José Antonio D; Preul, Mark C

    2010-11-01

    In a family of 7 siblings in Rio de Janeiro, Brazil, 2 of the most remarkable national personalities decided to follow different fields at the beginning of the 20th century. Their life's work would, however, intersect in at least 2 respects: the quest for innovation and a passion for sinuosity. The achievements of Paulo and Oscar Niemeyer are landmarks in the history of neurosurgery and architecture in Brazil. Among his many innovations in neurosurgery, Paulo Niemeyer first described the transventricular amygdalohippocampectomy in 1957 and introduced the operating microscope to neurosurgery in Brazil in 1971. His brother Oscar became a world-renowned representative of the modern architecture movement, sculpting graceful curves from concrete.

  20. 17. Photocopy of Photograph (Original Held by the Manning Brothers ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of Photograph (Original Held by the Manning Brothers Commercial Photographers, Madison Heights, Michigan, Negative No. 38750). SOUTHERN PORTION OF WEST FACADE, LOOKING NORTH, SHOWN ON EXTREME LEFT, 24 NOVEMBER 1920. - Basso Building, 7338 Woodward Avenue, Detroit, MI

  1. 18. Photocopy of Photograph (Original Held by the Manning Brothers ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photocopy of Photograph (Original Held by the Manning Brothers Commercial Photographers, Madison Heights, Michigan, Negative No. 67707). SOUTHERN PORTION OF WEST FACADE, LOOKING EAST, SHOWN ON EXTREME LEFT, 3 June 1925. - Basso Building, 7338 Woodward Avenue, Detroit, MI

  2. Precalcaneal congenital fibrolipomatous hamartomas: report of occurrence in half brothers.

    PubMed

    Fangman, William L; Prose, Neil S

    2004-01-01

    Precalcaneal congenital fibrolipomatous hamartomas are uncommon, congenital, nontender papules located on the medial plantar aspects of the heel. We report the occurrence of this rare disorder in two half brothers, suggesting that it may occur in a familial pattern.

  3. Different course of silicosis in four brothers of one family.

    PubMed

    Danila, Edvardas; Sileikiene, Virginija; Nargela, Remigijus; Zurauskas, Edvardas; Loskutoviene, Greta

    2009-01-01

    Silicosis remains a common occupational respiratory disease. Even in this era of highly sophisticated hygiene in European countries, new occupational cases of silicosis continue to be reported. Four cases of silicosis which developed after a relatively short occupational exposure to respirable silica among the members of one family are described. Four young men worked illegally abroad in mining in one of European countries. All of them were employed together in the same working conditions. One of the brothers died due to the acute form of the disease (lipoproteinosis). Two of the brothers suffered from simple nodular silicosis, and the fourth brother developed very early nodular silicosis and small airway dust disease. A one year follow-up revealed moderate/severe worsening of the disease in all surviving brothers.

  4. All in the Family: The Sister Study

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

  5. Eruptive history of South Sister, Oregon Cascades

    USGS Publications Warehouse

    Fierstein, J.; Hildreth, W.; Calvert, A.T.

    2011-01-01

    South Sister is southernmost and highest of the Three Sisters, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North Sister is a monotonously mafic edifice as old as middle Pleistocene, Middle Sister a basalt-andesite-dacite cone built between 48 and 14ka, and South Sister is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle Sister). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South Sister lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South Sister - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South Sister's flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the

  6. [Two Dutch sisters in analysis with Freud].

    PubMed

    Stroeken, Harry

    2010-01-01

    The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two sisters, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger sister to seek divorce.

  7. [Congenital insensitivity to pain: clinical and neurophysiological study in three sisters of a Moroccan family].

    PubMed

    Kissani, N; Krrati, H; Alarcon, G; Belaaidi, H; Ouazzani, R

    2013-11-01

    Congenital insensitivity to pain is a rare hereditary sensory and autonomic neuropathy (HSAN). This disorder is an autosomal recessive condition: since 1996, mutations attributed to this entity have been found in the neurotrophin tyrosine-kinase gene receptor on chromosome 1. The authors report 3 cases of congenital insensitivity to pain. In these 3 sisters of consanguineous parents, the clinical investigation showed total absence of pain and temperature sensations with preservation of all other sensory modalities, mental retardation, but in contrast to HSAN type IV, there was no anhidrosis. The neurophysiological investigation revealed an isolated axonal sensory polyneuropathy in the 3 patients. The clinical and neurophysiological investigations were normal in both parents and the brother. The physiopathology of this entity is discussed. We suggest a particular form of HSAN type IV with preservation of transpiration or a new entity of congenital insensitivity to pain, which should be analyzed genetically.

  8. Who Are My Sisters and Brothers? A Catholic Educational Guide for Understanding and Welcoming Immigrants and Refugees.

    ERIC Educational Resources Information Center

    United States Catholic Conference, Washington, DC.

    This educational guide, designed for use in Catholic elementary and secondary schools, religious education programs at all grades, youth retreats, teacher training, or parent and adult sessions, places issues related to immigrants and refugees in a Catholic perspective. It offers some basic materials to use and adapt for children and adults to…

  9. Biological versus nonbiological older brothers and men's sexual orientation.

    PubMed

    Bogaert, Anthony F

    2006-07-11

    The most consistent biodemographic correlate of sexual orientation in men is the number of older brothers (fraternal birth order). The mechanism underlying this effect remains unknown. In this article, I provide a direct test pitting prenatal against postnatal (e.g., social/rearing) mechanisms. Four samples of homosexual and heterosexual men (total n = 944), including one sample of men raised in nonbiological and blended families (e.g., raised with half- or step-siblings or as adoptees) were studied. Only biological older brothers, and not any other sibling characteristic, including nonbiological older brothers, predicted men's sexual orientation, regardless of the amount of time reared with these siblings. These results strongly suggest a prenatal origin to the fraternal birth-order effect.

  10. 3 CFR 8466 - Proclamation 8466 of December 16, 2009. Wright Brothers Day, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... December 16, 2009 Proc. 8466 Wright Brothers Day, 2009By the President of the United States of America A... Carolina, lifting two brothers from Dayton, Ohio, to their place in history. Their singular triumph... America, do hereby proclaim December 17, 2009, as Wright Brothers Day. IN WITNESS WHEREOF, I have...

  11. Family Constellations: Teaching Dave Etter's "Brother" (Modern Poetry in the Classroom).

    ERIC Educational Resources Information Center

    Totherow, Barbara

    1988-01-01

    Discusses how Dave Etter's poem "Brother" involves students by focusing on the themes of guilt and the love/hate complexity of a sibling relationship. Notes that Gina Berriault's story "The Stone Boy" and Harley Elliot's poem "Brothers Together in Winter" work well in conjunction with "Brother" as a thematic…

  12. 75 FR 46864 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Short Brothers PLC... this proposed AD, contact Short Brothers PLC, Airworthiness, P.O. Box 241, Airport Road, Belfast, BT3... new AD: Short Brothers PLC: Docket No. FAA-2010-0225; Directorate Identifier 2009-NM-203-AD....

  13. 75 FR 12154 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Short Brothers PLC... Brothers PLC, Airworthiness, P.O. Box 241, Airport Road, Belfast, BT3 9DZ Northern Ireland; telephone +44(0... 16, 2006) and adding the following new AD: Short Brothers PLC: Docket No. FAA-2010-0225;...

  14. How Big Is Too Big?

    ERIC Educational Resources Information Center

    Cibes, Margaret; Greenwood, James

    2016-01-01

    Media Clips appears in every issue of Mathematics Teacher, offering readers contemporary, authentic applications of quantitative reasoning based on print or electronic media. This issue features "How Big is Too Big?" (Margaret Cibes and James Greenwood) in which students are asked to analyze the data and tables provided and answer a…

  15. The brothers Lumière. Pioneers in medical photography.

    PubMed

    Aterman, K; Grimaud, J A

    1983-10-01

    A brief historical sketch of the brothers Lumière, the inventors of the cinématographe, is presented. Particular emphasis is placed on their perfection of "Autochromes," photographic plates suitable for color photography, and on their foresight in putting these advances to use in medical illustrations.

  16. Propaganda in Warner Brothers World War II Cartoons.

    ERIC Educational Resources Information Center

    Machowski, James Stanley; Brown, James William

    To examine the role of the animated cartoon in propaganda associated with World War II, 194 of 262 cartoons produced for theatrical release by Warner Brothers, Inc., from 1939 to 1946 were analyzed. Propaganda content was determined by the number and nature of symbols used and the cartoon's "attitudes" toward these symbols. An analysis…

  17. Crocodile Talk: Attributions of Incestuously Abused and Nonabused Sisters.

    ERIC Educational Resources Information Center

    Monahan, Kathleen

    1997-01-01

    This qualitative study analyzed the retrospective attributions of adult sisters (five abused sister dyads, and five abused and nonabused sister dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…

  18. Differences in Two Sisters' Acquisition of First Verbs.

    ERIC Educational Resources Information Center

    Braunwald, Susan R.

    This study examined prior qualitative differences in the process of the emergence of verb use in two sisters when they were each 12 to 24 months of age (the older sister is 2 years and 9 months older than the younger sister). Daily diaries on both children were kept by the mother, who noted emergent structure and vocabulary. Systematic Analysis of…

  19. Sisters of St. Joseph College Consortium: Mission and Image.

    ERIC Educational Resources Information Center

    Miller, Kathryn

    1995-01-01

    As part of a process of discerning the future direction and mission of the Sisters of Saint Joseph College Consortium (SSJCC), a year-long study of 11 institutions founded and run by the Sisters of Saint Joseph was undertaken. Sisters of Saint Joseph (SSJ) is a Roman Catholic women's religious congregation founded in 1836 which operates a…

  20. Suicide pact among three young sisters.

    PubMed

    Altindag, Abdurrahman; Yanik, Medaim

    2005-01-01

    A suicide pact is an agreement between two or more people to kill themselves. They represent 0.6-4.0% of all suicides, the vast majority being double suicides. We present a triple suicide pact involving three young sisters. Atypical features of this case include the number of participants, their young ages, and their good health conditions. Similarities to previously reported cases include participants having family disturbances, histories of depression and borderline personality.

  1. A Unique Case of Allogeneic Fat Grafting Between Brothers

    PubMed Central

    Kim, Samuel; Edelson, Richard L.; Sumpio, Brandon; Kwei, Stephanie

    2016-01-01

    Summary: We present a case of a 65-year-old man with cutaneous T-cell lymphoma treated with radiation therapy and an allogeneic hematopoietic stem cell transplant from his human leukocyte antigen-matched brother. Engraftment was successful, but the patient went on to develop painful, radiation-induced ulcers. The ulcers were fat-allografted using liposuctioned fat from his brother because of the patient’s unique chimeric state. Postprocedure follow-up revealed epithelialization of the ulcer sites and significant improvement in neuropathic pain. Our unique case study supports the use of fat grafting for its restorative purposes and for its ability to alleviate chronic neuropathic pain. Additionally, it appears that our case provides a basis of a general approach to the treatment of radiation-induced ulcers in chimeric patients with lymphoid malignancies. PMID:27757347

  2. Coloured sweat in two brothers: First report of familial chromhidrosis.

    PubMed

    Gaffney, Daniel C; Cooper, Hywel L

    2016-02-01

    The uncommon diagnosis of chromhidrosis is most frequently made in young adults. This sweat gland disease, although benign, may impact significantly on the patient's quality of life. We describe the first report of familial chromhidrosis of pseudo-eccrine type (pseudochromhidrosis) occurring in two brothers aged 9 and 12 years. The classification and causality of chromhidrosis is described and approaches to assessment and management are outlined.

  3. [Metabolic studies in brothers affected by alcaptonuria (ochronosis)].

    PubMed

    Pugge, H R; Orozco, M; Toledo, A; Ripoll, J; Katz, J; Toledo, I; Pellanda, R

    1978-01-01

    The case of two brothers affected by alcaptonurie is reported. The activity of the homogenthisycasa enzyme has been determined by the material obtained through percutaneous biopsy. Concentrations of the aminoacids producing fenilalanina and thiroxina in their parents' blood have been investigated, the tests showing lack of liver enzyme and normal concentration of the amount of aminoacids in blood. Some aspects of skin lesion have been briefly reported and methods for treatment presented.

  4. Big Surveys, Big Data Centres

    NASA Astrophysics Data System (ADS)

    Schade, D.

    2016-06-01

    Well-designed astronomical surveys are powerful and have consistently been keystones of scientific progress. The Byurakan Surveys using a Schmidt telescope with an objective prism produced a list of about 3000 UV-excess Markarian galaxies but these objects have stimulated an enormous amount of further study and appear in over 16,000 publications. The CFHT Legacy Surveys used a wide-field imager to cover thousands of square degrees and those surveys are mentioned in over 1100 publications since 2002. Both ground and space-based astronomy have been increasing their investments in survey work. Survey instrumentation strives toward fair samples and large sky coverage and therefore strives to produce massive datasets. Thus we are faced with the "big data" problem in astronomy. Survey datasets require specialized approaches to data management. Big data places additional challenging requirements for data management. If the term "big data" is defined as data collections that are too large to move then there are profound implications for the infrastructure that supports big data science. The current model of data centres is obsolete. In the era of big data the central problem is how to create architectures that effectively manage the relationship between data collections, networks, processing capabilities, and software, given the science requirements of the projects that need to be executed. A stand alone data silo cannot support big data science. I'll describe the current efforts of the Canadian community to deal with this situation and our successes and failures. I'll talk about how we are planning in the next decade to try to create a workable and adaptable solution to support big data science.

  5. The blood platelets contribution to innate host defense - what they have learned from their big brothers.

    PubMed

    Zander, Dorit M W; Klinger, Matthias

    2009-06-01

    Bactericidal effects of blood platelets have been known for more than 120 years, but the underlying mechanisms are largely obscure. Keeping in mind structural and functional analogies of platelets to neutrophils, three different mechanisms are thinkable: Engulfment of pathogens, release of microbicidal proteins, and production of reactive oxygen species (ROS). Here, we focus on the release of ROS and a possible contribution of blood plasma and thrombin to the bactericidal effects. Killing of bacteria was evaluated by DNA fluorescence labeling and electron microscopy. Release of ROS by platelets was measured photometrically by cytochrome C and phenol red/peroxidase assays and was further evaluated by topological methods. We found that (i) platelets produce 1500 times less O(2) (-) and 4000 times less H(2)O(2) compared to neutrophils, (ii) ROS do not affect the killing rates, and (iii) no local enrichment of ROS was detectable. On the other hand, thrombin and plasma proteins with a molecular mass of >100 kDa are essential for bactericidal effects. We suggest that platelets contribute to the innate host defense by providing a catalytical surface for synthesis of thrombin. In the presence of a heat-instable plasma protein, thrombin may generate a strong bactericidal complex, which is only effective in close vicinity to the platelet membrane.

  6. Big Brother Is Helping You: Supporting Self-Access Language Learning with a Student Monitoring System

    ERIC Educational Resources Information Center

    Reinders, Hayo

    2007-01-01

    Self-access and language advising are relatively recent and increasingly common types of language support offered in schools and tertiary institutions around the world. There is a great deal of anecdotal support for the positive contribution of such support to student learning. Self-access and language advising hold strong potential as…

  7. Big brother - a fully automated control system for the DELPHI experiment

    SciTech Connect

    Franek, B.; Sekulin, R.; Doenszelmann, M.; Gasper, C.; Charpentier, Jonker, M.

    1994-12-31

    The integrated control system of the DELPHI experiment is described. It allows the data to be taken in an almost automatic fashion. This is achieved by computer monitoring of the states of the LEP machine, the DELPHI subdetectors (SC) and the Data Acquisition System (DAS). Depending on these states, computer initiated actions are then taken. It has been designed using {open_quote}State Manager{close_quote} concept already used for local and central controls of DAS and SC.

  8. George Orwell and Modern Science Fiction: The Legacy of Big Brother.

    ERIC Educational Resources Information Center

    Lerner, Fred

    1984-01-01

    Discusses George Orwell's lack of influence on modern science fiction and presents a selected annotated bibliography of modern science fiction materials depicting a wide variety of totalitarian societies. (MBR)

  9. Big Brother and the National Reading Curriculum: How Ideology Trumped Evidence.

    ERIC Educational Resources Information Center

    Allington, Richard

    This book about reading tracks and questions the 30-year campaign that has focused on testing, accountability, and federalization of education to demonstrate that it is not just whole language advocates who are having problems with the National Reading Panel report and the new education laws. The book gathers together a comprehensive collection of…

  10. When big brother is watching: goal orientation shapes reactions to electronic monitoring during online training.

    PubMed

    Watson, Aaron M; Foster Thompson, Lori; Rudolph, Jane V; Whelan, Thomas J; Behrend, Tara S; Gissel, Amanda L

    2013-07-01

    Web-based training is frequently used by organizations as a convenient and low-cost way to teach employees new knowledge and skills. As web-based training is typically unproctored, employees may be held accountable to the organization by computer software that monitors their behaviors. The current study examines how the introduction of electronic performance monitoring may provoke negative emotional reactions and decrease learning among certain types of e-learners. Through motivated action theory and trait activation theory, we examine the role of performance goal orientation when e-learners are exposed to asynchronous and synchronous monitoring. We show that some e-learners are more susceptible than others to evaluation apprehension when they perceive their activities are being monitored electronically. Specifically, e-learners higher in avoid performance goal orientation exhibited increased evaluation apprehension if they believed asynchronous monitoring was present, and they showed decreased skill attainment as a result. E-learners higher on prove performance goal orientation showed greater evaluation apprehension if they believed real-time monitoring was occurring, resulting in decreased skill attainment.

  11. Brown and polar bear Y chromosomes reveal extensive male-biased gene flow within brother lineages.

    PubMed

    Bidon, Tobias; Janke, Axel; Fain, Steven R; Eiken, Hans Geir; Hagen, Snorre B; Saarma, Urmas; Hallström, Björn M; Lecomte, Nicolas; Hailer, Frank

    2014-06-01

    Brown and polar bears have become prominent examples in phylogeography, but previous phylogeographic studies relied largely on maternally inherited mitochondrial DNA (mtDNA) or were geographically restricted. The male-specific Y chromosome, a natural counterpart to mtDNA, has remained underexplored. Although this paternally inherited chromosome is indispensable for comprehensive analyses of phylogeographic patterns, technical difficulties and low variability have hampered its application in most mammals. We developed 13 novel Y-chromosomal sequence and microsatellite markers from the polar bear genome and screened these in a broad geographic sample of 130 brown and polar bears. We also analyzed a 390-kb-long Y-chromosomal scaffold using sequencing data from published male ursine genomes. Y chromosome evidence support the emerging understanding that brown and polar bears started to diverge no later than the Middle Pleistocene. Contrary to mtDNA patterns, we found 1) brown and polar bears to be reciprocally monophyletic sister (or rather brother) lineages, without signals of introgression, 2) male-biased gene flow across continents and on phylogeographic time scales, and 3) male dispersal that links the Alaskan ABC islands population to mainland brown bears. Due to female philopatry, mtDNA provides a highly structured estimate of population differentiation, while male-biased gene flow is a homogenizing force for nuclear genetic variation. Our findings highlight the importance of analyzing both maternally and paternally inherited loci for a comprehensive view of phylogeographic history, and that mtDNA-based phylogeographic studies of many mammals should be reevaluated. Recent advances in sequencing technology render the analysis of Y-chromosomal variation feasible, even in nonmodel organisms.

  12. Big Opportunities and Big Concerns of Big Data in Education

    ERIC Educational Resources Information Center

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  13. Big Dreams

    ERIC Educational Resources Information Center

    Benson, Michael T.

    2015-01-01

    The Keen Johnson Building is symbolic of Eastern Kentucky University's historic role as a School of Opportunity. It is a place that has inspired generations of students, many from disadvantaged backgrounds, to dream big dreams. The construction of the Keen Johnson Building was inspired by a desire to create a student union facility that would not…

  14. Big bluestem

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Big Bluestem (Andropogon gerardii) is a warm season grass native to North America, accounting for 40% of the herbaceous biomass of the tall grass prairie, and a candidate for bioenergy feedstock production. The goal of this study was to measure among and within population genetic variation of natura...

  15. 77 FR 24554 - Culturally Significant Objects Imported for Exhibition; Determinations: “Quay Brothers: On...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... Pharmacist's Prescription for Lip-Reading Puppets'' AGENCY: State Department. ACTION: Notice. SUMMARY: Notice... objects to be included in the exhibition ``Quay Brothers: On Deciphering the Pharmacist's Prescription...

  16. EarthLabs Meet Sister Corita Kent

    NASA Astrophysics Data System (ADS)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  17. Human factors of powered flight: the Wright brothers' contributions.

    PubMed

    Mohler, Stanley R

    2004-02-01

    Orville and Wilbur Wright of Dayton, OH, not only were the first to fly a powered aircraft, but also pioneered many human factors considerations. While others tried to develop aircraft with a high degree of aerodynamic stability, the Wrights intentionally designed unstable aircraft with "cerebralized" control modeled on bird flight. During 1901-03, the brothers worked with large gliders at Kill Devil Hills, near Kitty Hawk, NC, to develop the first practical human-interactive controls for aircraft pitch, roll, and yaw. On December 17, 1903, they made four controlled, powered flights over the dunes at Kitty Hawk with their Wright Flyer. During the next 2 yr, the Wrights made numerous flights in the Wright Flyers II and III at Huffman Prairie near Dayton. They later developed practical in-flight control of engine power, plus an angle-of-attack sensor and stick-pusher that reduced pilot workload. The brothers' flight demonstrations in the U.S. and Europe during 1908-09 awakened the world to the new age of controlled flight. Orville was the first aviator to use a seat belt. He also introduced a rudder boost/trim control that gave the pilot greater control authority. The Wrights' flight training school in Dayton included a flight simulator of their own design. The Wrights patented their practical airplane and flight control concepts, many of which are still in use today.

  18. 75 FR 30831 - Cooksey Brothers Landfill Fire Superfund Site; Ashland, Boyd County, KY; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    .... Painter. Submit your comments, identified by Docket ID No. EPA-RO4- SFUND-2010- 0447 or Site name Cooksey... AGENCY Cooksey Brothers Landfill Fire Superfund Site; Ashland, Boyd County, KY; Notice of Settlement... costs concerning the Cooksey Brothers Landfill Fire Superfund Site located in Ashland, Boyd...

  19. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Hansen, Jennifer; Martin, Cam

    2007-01-01

    Viewgraphs showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  20. Gliding Experiments of the Wright Brothers: Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Cole, Jennifer Hansen; Martin, John Campbell

    2011-01-01

    Presentation showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905, Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  1. Creating Sister Cities: An Exchange Across Hemispheres

    NASA Astrophysics Data System (ADS)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  2. Christ-siemens-touraine syndrome: case report of 2 brothers.

    PubMed

    Vora, Rita V; Anjaneyan, Gopikrishnan; Chaudhari, Arvind; Pilani, Abhishek P

    2014-10-01

    Ectodermal dysplasia is a rare disorder. Christ-Siemens-Touraine syndrome (Hypohidrotic Ectodermal dysplasia (HED)) is a diffuse, non-progressive disease present at birth and involves at least two tissues of ectodermal origin. It is caused by mutation in gene ectodysplasin (EDA, EDA1) located at Xq12-13. Main clinical feature of HED is sparse or absent eccrine gland as well as hypotrichosis, nail, and teeth abnormality with characteristic faces. The absence or diminished activity of sweat gland results in patients having more chances of developing hyperthermia and with intolerance to warm environment. Most do well with simple measures such as wet clothes, air conditioning, wet bands etc. We present cases of two brothers, born of non-consanguineous marriage, who presented to us with complaints of heat intolerance and abnormal facial features.

  3. [History of the Cracow Brothers of Mercy Hospital].

    PubMed

    Gaertner, H

    1995-01-01

    The oldest of existing Cracow hospitals was founded in 1609. The paper discusses the origins, development and decay of the hospital-cloister in its first seat at St. John's and St. Mark's streets. Later the author describes the fate of the hospital-cloister from 1812 after its translocation to the second residence at the Krakowska street. In 1906 the third seat became a new buildings' complex at the Trynitarska street. The work remembers the role of the hospital during several epidemies, Ist and IInd World War and its activity during peace times. The author emphasizes the great merits of Brothers of Mercy for Cracow medicine and hospital system in bringing medical and charitable help to sick and poor.

  4. Breast cancer after Hodgkin's disease in two sisters

    SciTech Connect

    Li, F.P.; Corkery, J.; Canellos, G.; Neitlich, H.W.

    1981-01-01

    Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.

  5. A non-sister act: recombination template choice during meiosis.

    PubMed

    Humphryes, Neil; Hochwagen, Andreas

    2014-11-15

    Meiotic recombination has two key functions: the faithful assortment of chromosomes into gametes and the creation of genetic diversity. Both processes require that meiotic recombination occurs between homologous chromosomes, rather than sister chromatids. Accordingly, a host of regulatory factors are activated during meiosis to distinguish sisters from homologs, suppress recombination between sister chromatids and promote the chromatids of the homologous chromosome as the preferred recombination partners. Here, we discuss the recent advances in our understanding of the mechanistic basis of meiotic recombination template choice, focusing primarily on developments in the budding yeast, Saccharomyces cerevisiae, where the regulation is currently best understood.

  6. Horsetails are the sister group to all other monilophytes and Marattiales are sister to leptosporangiate ferns.

    PubMed

    Knie, Nils; Fischer, Simon; Grewe, Felix; Polsakiewicz, Monika; Knoop, Volker

    2015-09-01

    The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the sister clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes. Both introns have orthologues in seed plants where nad2i542g2 has evolved into a trans-arrangement. In contrast and despite substantial size extensions to more than 5kb in Psilotum, nad2i542g2 remains cis-arranged in the monilophytes. For phylogenetic analyses, we filled taxonomic gaps in previously investigated mitochondrial (atp1, nad5) and chloroplast (atpA, atpB, matK, rbcL, rps4) loci and created a 9-gene matrix that also included the new mitochondrial nad2 and rpl2 loci. We extended the taxon sampling with two taxa each for all land plant outgroups (liverworts, mosses, hornworts, lycophytes and seed plants) to minimize the risk of phylogenetic artefacts. We ultimately obtained a well-supported molecular phylogeny placing Marattiales as sister to leptosporangiate ferns and horsetails as sister to all remaining monilophytes. In addition, an indel in an exon of the here introduced rpl2 locus independently supports the placement of horsetails. We conclude that under dense taxon sampling, phylogenetic information from a prudent choice of loci is currently superior to character-rich phylogenomic approaches at low taxon sampling. As here shown the selective choice of loci and taxa enabled us to resolve the long-enigmatic diversifications of the earliest monilophyte lineages.

  7. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2008-01-01

    This viewgraph presentation reviews the Wright Brothers's flight research during the 10 years between 1899 and 1908. The Wright Brothers began their research in flight with gliders. The presentation shows pictures, replicas and characteristics of the gliders that the Wright Brothers used. This presentation is not just a history lesson. In the end it investigates "What Does Flight Research Accomplish?" Flight research can serve many uses, such as Separates the Real from the Imagined, Uncovers the Unexpected and the Overlooked, Forces the Realistic Integration of the Pilot, Forces the Development of Reliable Prediction and Test Processes, Requires Every Problem to Be Addressed, Promotes Technology Transfer, and Builds a Core Technical Team,

  8. How-to-Do-It: Demonstrating Sister Chromatid Exchanges.

    ERIC Educational Resources Information Center

    Dye, Frank J.

    1988-01-01

    Outlines procedures for demonstrating and preparing a permanent slide of sister chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)

  9. Agenesis of the Corpus Callosum in Two Sisters

    PubMed Central

    Shapira, Yehuda; Cohen, Tirza

    1973-01-01

    Two sisters are described. They are offspring of Arabic parents who are both first and second cousins, through both sets of grandparents; additionally the father's parents are first cousins. The diagnosis of agenesis of the corpus callosum in the propositae was made by the characteristic picture on the pneumoencephalogram. The clinical symptoms in the two sisters varied considerably. The older sister had shown delayed psychomotor development in infancy, mild mental retardation, and developed seizures at 7 years of age of both the grand mal and akinetic types. Her physical and neurological examination did not show any abnormalities. The EEG was severely abnormal with slow wave activity over the posterior parts of the brain and focal spiking. The younger sister presented at 6 months of age with failure to thrive, generalized hypotonia, but without seizures. Her EEG was within normal limits. This anomaly was probably transmitted by an autosomal recessive gene. The clinical and genetic aspects of this syndrome are discussed. Images PMID:4204338

  10. Sister kinetochores are mechanically fused during meiosis I in yeast.

    PubMed

    Sarangapani, Krishna K; Duro, Eris; Deng, Yi; Alves, Flavia de Lima; Ye, Qiaozhen; Opoku, Kwaku N; Ceto, Steven; Rappsilber, Juri; Corbett, Kevin D; Biggins, Sue; Marston, Adèle L; Asbury, Charles L

    2014-10-10

    Production of healthy gametes requires a reductional meiosis I division in which replicated sister chromatids comigrate, rather than separate as in mitosis or meiosis II. Fusion of sister kinetochores during meiosis I may underlie sister chromatid comigration in diverse organisms, but direct evidence for such fusion has been lacking. We used laser trapping and quantitative fluorescence microscopy to study native kinetochore particles isolated from yeast. Meiosis I kinetochores formed stronger attachments and carried more microtubule-binding elements than kinetochores isolated from cells in mitosis or meiosis II. The meiosis I-specific monopolin complex was both necessary and sufficient to drive these modifications. Thus, kinetochore fusion directs sister chromatid comigration, a conserved feature of meiosis that is fundamental to Mendelian inheritance.

  11. 38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal conveyor, blast stoves, "A" furnace, stoves, "B" furnace, stoves, "C" furnace, bottle cars. Looking south - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  12. UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED TO OLDER BEAMS, NEW STRINGERS AND COMPONENTS MAKE UP A NEARLY NEW SUPPORT SYSTEM - Short Bridge, Spanning South Santiam River at High Deck Road, Cascadia, Linn County, OR

  13. Developing skills in clinical leadership for ward sisters.

    PubMed

    Fenton, Katherine; Phillips, Natasha

    The Francis report has called for a strengthening of the ward sister's role. It recommends that sisters should operate in a supervisory capacity and should not be office bound. Effective ward leadership has been recognised as being vital to high-quality patient care and experience, resource management and interprofessional working. However, there is evidence that ward sisters are ill equipped to lead effectively and lack confidence in their ability to do so. University College London Hospitals Foundation Trust has recognised that the job has become almost impossible in increasingly large and complex organisations. Ward sisters spend less than 40% of their time on clinical leadership and the trust is undertaking a number of initiatives to support them in this role.

  14. Two sisters resembling Gorlin-Chaudhry-Moss syndrome.

    PubMed

    Aravena, Teresa; Passalacqua, Cristóbal; Pizarro, Oscar; Aracena, Mariana

    2011-10-01

    The Gorlin-Chaudhry-Moss syndrome (GCMS), was describe initially by Gorlin et al. [Gorlin et al. (1960)] in two sisters with craniosynostosis, hypertrichosis, hypoplastic labia majora, dental defects, eye anomalies, patent ductus arteriosus, and normal intelligence. Two other sporadic instances have been documented. Here, we report on two sisters with a condition with some similarities to GCMS as well as some differences, which could represent either previously unreported variability in GCMS, or it may represent a novel disorder.

  15. Sister chromatid decatenation: bridging the gaps in our knowledge

    PubMed Central

    Broderick, Ronan; Niedzwiedz, Wojciech

    2015-01-01

    Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process. PMID:26266709

  16. Similar Sister Chromatid Arrangement in Mono- and Holocentric Plant Chromosomes.

    PubMed

    Schubert, Veit; Zelkowski, Mateusz; Klemme, Sonja; Houben, Andreas

    2016-01-01

    Due to the X-shape formation at somatic metaphase, the arrangement of the sister chromatids is obvious in monocentric chromosomes. In contrast, the sister chromatids of holocentric chromosomes cannot be distinguished even at mitotic metaphase. To clarify their organization, we differentially labelled the sister chromatids of holocentric Luzula and monocentric rye chromosomes by incorporating the base analogue EdU during replication. Using super-resolution structured illumination microscopy (SIM) and 3D rendering, we found that holocentric sister chromatids attach to each other at their contact surfaces similar to those of monocentrics in prometaphase. We found that sister chromatid exchanges (SCEs) are distributed homogeneously along the whole holocentric chromosomes of Luzula, and that their occurrence is increased compared to monocentric rye chromosomes. The SCE frequency of supernumerary B chromosomes, present additionally to the essential A chromosome complement of rye, does not differ from that of A chromosomes. Based on these results, models of the sister chromatid arrangement in mono- and holocentric plant chromosomes are presented.

  17. Proposed Penalty Against Wood Brothers Trucking & Construction and Jason Carnahan for Clean Water Act Violations

    EPA Pesticide Factsheets

    Public notice of EPA's proposed penalty against Wood Brothers Trucking & Construction and Jason Carnahan for violations of the Clean Water Act at their construction site located outside of Boise, Idaho.

  18. Doing What Your Big Sister Does: Sex, Postfeminism and the YA Chick Lit Series

    ERIC Educational Resources Information Center

    Bullen, Elizabeth; Toffoletti, Kim; Parsons, Liz

    2011-01-01

    Mass-marketed teen chick lit has become a publishing phenomenon and has begun to attract critical interest among children's literature scholars. Much of this critical work, however, has shied away from robust critical assessment of the postfeminist conditions informing the production and reception of young adult series like Private, Gossip Girl…

  19. Band of Brothers - Warrior Ethos, Unit Effectiveness and the Role of Initial Entry Training

    DTIC Science & Technology

    2006-05-31

    happy few, we band of brothers; for he today that sheds his blood with me shall be my brother. William Shakespeare Initial Entry Training (IET) in the...the U.S. Army.”52 Unable to strike at the Army, who they felt had forgotten them, the men struck at the inhabitants of Mai Lai 4, a hamlet in the Quang

  20. The Montgolfier Brothers and the Invention of Aviation

    NASA Astrophysics Data System (ADS)

    Moore, Charles B.

    The first hot air balloon ascension over Paris in September 1783 has been described so many times that it and its passengers—the sheep, the rooster, and the duck—have joined Benjamin Franklin and his kite in the folklore of our culture. Not so well known is the earlier history of ballooning; that the brothers Montgolfier had demonstrated their hot air balloons repeatedly for several months prior to the ascent over Paris; or that the physicist Charles, urged onward and financed by an enthusiast, Barthélemy Faujas de Saint-Fond, launched successfully the first fabric balloon filled with hydrogen over Paris more than 3 weeks prior to the memorable ascent of the sheep, and rooster, and the duck.For all of its well-documented detail, the book is readable and enjoyable. It is a well-written but complex book in which Professor Gillispie develops a number of subjects to recreate the era in perspective. The origins and the disposition of the Montgolfiers, the industry of the period, the idea of capturing heated air are all reported in detail. The attempts to obtain government funding and the promotional activities in Paris were forerunners of the modern techniques for obtaining support of research activities.

  1. [Nutritional status of two generations of brothers and sisters <5 years of age beneficiaries from opportunities living in marginalized rural communities in Chiapas, Mexico].

    PubMed

    García-Parra, Esmeralda; Ochoa-Díaz-López, Héctor; García-Miranda, Rosario; Moreno-Altamirano, Laura; Morales, Helda; Estrada-Lugo, Erin Ingrid Jane; Solís-Hernández, Roberto

    2015-06-01

    En México, en las últimas décadas se han desarrollado varios programas para erradicar el problema de la desnutrición en infantes < de 5 años, principalmente de aquellos que viven en áreas indígenas y rurales. No obstante, no existe suficiente evidencia sobre su impacto en la salud y la nutrición infantil. Objetivo: describir los cambios nutricionales de dos generaciones de hermanos(as) que han sido beneficiados por el programa Oportunidades en comunidades rurales de Chiapas. Métodos: estudio transversal. Se determinó: bajo peso, baja talla, emaciación y SP + O (Sobrepeso más Obesidad). Los hermanos(as) mayores fueron evaluados en los años 2002-2003, para el 2010-2011 se evaluaron a los hermanos( as) menores, ambos grupos eran < de 5 años de edad en el momento de conseguir la información. Resultados: la desnutrición en sus tres formas es un problema, 43,4% de los hermanos(as) evaluados(as) en 2010-2011 presentaron baja talla, la prevalencia de bajo peso disminuyó de 18% a 13,2%, la emaciación (peso bajo para la talla) aumentó de 8,1% a 10.4%. El SP + O aumentó significativamente 12 puntos porcentuales entre los hermanos(as) de 24,8% en 2002-2003 a 36,8% en 2010-2011. La desnutrición en los niños (varones) es menor que la de sus hermanos de la generación de 2002- 2003 (baja talla p =.

  2. Do Brothers Affect Their Sisters' Chances to Graduate? An Analysis of Sibling Sex Composition Effects on Graduation from a University or a "Fachhochschule" in Germany

    ERIC Educational Resources Information Center

    Jacob, Marita

    2011-01-01

    In a recent paper on gender inequality in higher education Buchman and DiPrete (2006) assume that the decrease in the gender gap in college completion in the US can partly be explained by changes in the allocation of familial resources in favour of women. However, they do not test this hypothesis empirically. In this paper I examine the effects of…

  3. Brother-Sister Differences in the g Factor in Intelligence: Analysis of Full, Opposite-Sex Siblings from the NLSY1979

    ERIC Educational Resources Information Center

    Deary, Ian J.; Irwing, Paul; Der, Geoff; Bates, Timothy C.

    2007-01-01

    There is scientific and popular dispute about whether there are sex differences in cognitive abilities and whether they are relevant to the proportions of men and women who attain high-level achievements, such as Nobel Prizes. A recent meta-analysis (Lynn, R., and Irwing, P. (2004). Sex differences on the progressive matrices: a meta-analysis.…

  4. Brother is high Sr/Y two-mica granite and sister is leucogranite: twin granites in the Northern Himalayan Gneiss Domes, southern Tibet

    NASA Astrophysics Data System (ADS)

    Zeng, L.; Gao, L.; Xie, K.

    2011-12-01

    Leucogranites in the Himalayan orogen is widely considered as the type example of crustal melts, which provides a probe to investigate the interplay among high-grade metamorphism, crustal anatexis, and tectonic transition in large-scale collisional belts. Whether the leucogranite was a daughter product from a more primitive granitic melt is an interesting question that deserves careful examination to address the above issue. We report a new suite of two-mica granite (TMG) and leucogranite (LG) in the Yardoi gneiss dome (YGD) in the easternmost of the Northern Himalayan Gneiss Domes (NHGD), south of the Yarlung-Tsangpo suture. SHRIMP and LA-ICP-MS zircon U/Pb dating show that TMG and LG formed at ~17.7 Ma to ~20.0 Ma and at ~17.1 Ma, respectively. Both suites of granite have high Na/K (>1.30) ratios. The TMGs are characterized by (1) high Sr (>450 ppm), low Rb (<95 ppm) and Y (<6 ppm), and high Sr/Y (>86) ratios; (2) no Eu anomalies; and (3) low initial 87Sr/86Sr ratios (<0.7098) and higher ɛNd (>-8.5) values. In contrast, the LGs have (1) lower Sr (<130 ppm) and higher Rb (92-130 ppm); (2) pronounced negative Eu anomalies with Eu/Eu*<0.55; and (3) relatively higher Sr (87Sr/86Sr(t) =0.7136-0.7148) and unradiogenic Nd (ɛNd(t)=-7.7~-11.1). These data demonstrate that these Mid-Miocene granites have major and trace element and radiogenic isotope compositions similar to those of >35 Ma granites, but significantly different from those granites of similar ages in the High Himalaya as well as in the NHGD. High Sr/Y and relatively unradiogenic Sr isotope compositions in the TMGs could be derived from partial melting of mafic materials formed during previous compressional thickening event which was triggered by the input of juvenile heat and material associated with the Miocene E-W extension. An AFC process (plagioclase fractional crystallization and contamination by crustal materials) could be a primary factor leading to the formation of these LGs. Concurrence of high Sr/Y granites and leucogranites in NHGD indicates that the Miocene rifting could have played an important but previously unrecognized role in producing the Himalayan leucogranite. Similarly, the ~43-44 Ma high Sr/Y two-mica granites were also accompanied by the formation of typical leucogranite. However, the Mid-Eocene suite was derived from melting of lower crustal mafic materials at overthickened crustal conditions. Concurrence of high Sr/Y granites and typical leucogranites in the NHGD demonstrates that leucogranites could be derived from more primitive granitic melts by AFC process.

  5. Volcano hazards in the Three Sisters region, Oregon

    USGS Publications Warehouse

    Scott, William E.; Iverson, R.M.; Schilling, S.P.; Fisher, B.J.

    2001-01-01

    Three Sisters is one of three potentially active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. Two types of volcanoes exist in the Three Sisters region and each poses distinct hazards to people and property. South Sister, Middle Sister, and Broken Top, major composite volcanoes clustered near the center of the region, have erupted repeatedly over tens of thousands of years and may erupt explosively in the future. In contrast, mafic volcanoes, which range from small cinder cones to large shield volcanoes like North Sister and Belknap Crater, are typically short-lived (weeks to centuries) and erupt less explosively than do composite volcanoes. Hundreds of mafic volcanoes scattered through the Three Sisters region are part of a much longer zone along the High Cascades of Oregon in which birth of new mafic volcanoes is possible. This report describes the types of hazardous events that can occur in the Three Sisters region and the accompanying volcano-hazard-zonation map outlines areas that could be at risk from such events. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three Sisters and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three Sisters and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the

  6. The template choice decision in meiosis: is the sister important?

    PubMed

    Pradillo, Mónica; Santos, Juan L

    2011-10-01

    Recombination between homologous chromosomes is crucial to ensure their proper segregation during meiosis. This is achieved by regulating the choice of recombination template. In mitotic cells, double-strand break repair with the sister chromatid appears to be preferred, whereas interhomolog recombination is favoured during meiosis. However, in the last year, several studies in yeast have shown the importance of the meiotic recombination between sister chromatids. Although this thinking seems to be new, evidences for sister chromatid exchange during meiosis were obtained more than 50 years ago in non-model organisms. In this mini-review, we comment briefly on the most recent advances in this hot topic and also describe observations which suggest the existence of inter-sister repair during meiotic recombination. For instance, the behaviour of mammalian XY bivalents and that of trivalents in heterozygotes for chromosomal rearrangements are cited as examples. The "rediscovering" of the requirement for the sister template, although it seems to occur at a low frequency, will probably prompt further investigations in organisms other than yeast to understand the complexity of the partner choice during meiosis.

  7. Sister chromatid segregation in meiosis II: deprotection through phosphorylation.

    PubMed

    Wassmann, Katja

    2013-05-01

    Meiotic divisions (meiosis I and II) are specialized cell divisions to generate haploid gametes. The first meiotic division with the separation of chromosomes is named reductional division. The second division, which takes place immediately after meiosis I without intervening S-phase, is equational, with the separation of sister chromatids, similar to mitosis. This meiotic segregation pattern requires the two-step removal of the cohesin complex holding sister chromatids together: cohesin is removed from chromosome arms that have been subjected to homologous recombination in meiosis I and from the centromere region in meiosis II. Cohesin in the centromere region is protected from removal in meiosis I, but this protection has to be removed--deprotected--for sister chromatid segregation in meiosis II. Whereas the mechanisms of cohesin protection are quite well understood, the mechanisms of deprotection have been largely unknown until recently. In this review I summarize our current knowledge on cohesin deprotection.

  8. little sister: An Afro-Temporal Solo-Play.

    PubMed

    De Berry, Misty

    2016-09-12

    little sister: An Afro-Temporal Solo-Play is at once a memory-scape and a mytho-biography set to poetry, movement, and mixed media. A performance poem spanning from the Antebellum South to present-moment Chicago, it tells the story of a nomadic spirit named little-she who shape-shifts through the memories and imaginings of her sister, the narrator. Through the characters little-she and the narrator, the solo-performance explores embodied ways to rupture and relieve the impact of macro forms of violence in the micro realm of the everyday. To this end, little sister witnesses and disrupts the legacy of violence in the lives of queer Black women through a trans-temporal navigation of everyday encounters within familial, small groups and intimate partner spaces.

  9. Five Big Ideas

    ERIC Educational Resources Information Center

    Morgan, Debbie

    2012-01-01

    Designing quality continuing professional development (CPD) for those teaching mathematics in primary schools is a challenge. If the CPD is to be built on the scaffold of five big ideas in mathematics, what might be these five big ideas? Might it just be a case of, if you tell me your five big ideas, then I'll tell you mine? Here, there is…

  10. Parallel phylogeographic structure in ecologically similar sympatric sister taxa.

    PubMed

    Dawson, Michael N

    2012-02-01

    Present-day phylogeographic patterns have been shaped by the dual histories of lineages and places, producing a diversity of relationships that may challenge discovery of general rules. For example, the predicted positive correlation between dispersal ability and gene flow has been supported inconsistently, suggesting unaccounted complexity in theory or the comparative framework. Here, I extend the sympatric sister-species approach, in which variance between lineages and places is minimized, to sister clades and test a fundamental assumption of comparative genetic studies of dispersal: that taxa which evolved at the same time and in the same place will, if they have similar life histories and ecologies, have essentially the same phylogeographic structure. Phylogenetic analyses of 197 Stigmatopora pipefishes using two nuclear (creatine kinase intron 6, α-tropomyosin) and two mitochondrial (16S, noncoding region) loci revealed largely synchronous parallel diversification of sister clades that are codistributed from Western Australia to New Zealand, supporting the null hypothesis. Only one comparison, however, yielded a sympatric sister-species pair (the two stem species), so I also explored the potential for extant species sharing a substantial proportion of their evolutionary histories in sympatry to substitute for sister taxon comparisons. In eastern Australia, where strong environmental structure is lacking, phylogeographic differences between species that have been codistributed for ~85% of their evolutionary histories were consistent with tendencies favoured by their modest life-history differences, that is the larger, rarer species had lower genetic diversity. In contrast, in New Zealand, two species codistributed for ~70% of their evolutionary histories were both structured similarly by a strong biogeographic filter despite differences in life history. Rigorously quantifying the influence of intrinsic and extrinsic factors on phylogeographic structure may

  11. Catholic sister nurses in Selma, Alabama, 1940-1972.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters' work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South.

  12. The Essene's sister sect in Egypt: another medical site?

    PubMed

    Moss, G A

    2002-12-01

    The Essenes were, allegedly, the authors of the Dead Sea Scrolls and were settled by the Dead Sea. An ancient source locates their sister sect, The 'Therapeutae', as being by the shores of Lake Mareotis in Egypt. No scholar has previously sought to locate where exactly on Lake Mareotis they were settled. Using clues from Essene sites around the Dead Sea, an attempt is made to suggest a specific location for the Therapeutae. Since there are signs of medical activity at many of the Essene sites, a site with medical association is also sought for the location of the Essene's sister sect in Egypt. A suitable site is found at Canopus.

  13. Japanese sisters with Pfeiffer syndrome and achondroplasia: a mutation analysis.

    PubMed

    Nagase, T; Nagase, M; Hirose, S; Ohmori, K

    1998-09-01

    The authors report the rare existence of a family that includes an older sister with Pfeiffer syndrome and a younger sister with achondroplasia. Gene analysis of these patients showed a T341P mutation in the FGFR2 gene in the patient with Pfeiffer syndrome, and a G380R mutation in the FGFR3 gene in the patient with achondroplasia. Both mutations have been reported previously. Their parents had no mutation in either locus. This result suggests the possibility that there may be predisposing factors for different FGFR mutations.

  14. [Florence Nightingale and charity sisters: revisiting the history].

    PubMed

    Padilha, Maria Itayra Coelho de Souza; Mancia, Joel Rolim

    2005-01-01

    This study presents an historical analysis on the links between the nursing practice and the influence received from various religious orders/associations along the times, especially from Saint Vincent Paul's charity sisters. The professional nursing which was pioneered by Florence Nightingale in the XlXth century, was directly influenced by the teachings of love and fraternity. In addition, other contributions from the religious orders/associations were the concepts of altruism, valorization of an adequate environment for the care of patients, and the division of work in nursing. The study shows the influence of Charity Sisters on Florence Nightingale.

  15. Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.

    PubMed

    Blattner, Ariane C; Chaurasia, Soumya; McKee, Bruce D; Lehner, Christian F

    2016-04-01

    Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase.

  16. Extreme right-handedness, older brothers, and sexual orientation in men.

    PubMed

    Bogaert, Anthony F

    2007-01-01

    Two of the most consistent correlates of sexual orientation in men are handedness and fraternal birth order (i.e., number of older brothers). In the present study, the relationship among handedness, older brothers, and sexual orientation was studied in 4 samples of heterosexual and gay or bisexual men (N = 944). Unlike previous studies, which have only observed an increased rate of non-right-handedness in gay or bisexual men relative to heterosexual men, an elevated rate of extreme right-handedness was found in gay or bisexual men relative to heterosexual men. The results also demonstrated that older brothers moderate the relationship between handedness and sexual orientation. Specifically, older brothers increase the odds of being gay or bisexual in moderate right-handers only; in both non-right-handers and extreme right-handers, older brothers do not affect (or decrease) the odds of being gay or bisexual. The results have implications for an early neurodevelopmental origin to sexual orientation in men.

  17. Fragile X syndrome: Discordant levels of CGG repeat mosaicism in two brothers

    SciTech Connect

    Mueller, O.T.; Hartsfield, J.K. Jr.; Amar, M.J.A.

    1995-08-14

    Fragile X syndrome is associated with an unstable repeated CGG trinucleotide sequence in the 5{prime} untranslated region of the FMR-1 gene. A significant number of individuals with a mild or atypical presentation are mosaics for the CGG expansion. We report a family with two brothers. The proband had severe mental retardation as well as most of the Fragile X syndrome stigmata, whereas his brother shows only mild learning difficulties. Both inherited a 80 x CGG trinucleotide premutation from the mother. They were negative for the FRAXA fragile site in over 100 metaphases examined. Flanking markers verified that both had inherited the same FMR-1 allele and Xq27-q28 flanking sequences from the mother. The methylation status of the brothers indicated active FMR-1 transcription as determined by using StB12.3/EcoRI + Eagl blots. CGG size or methylation mosaicism was not apparent from Southern blots. Polymerase chain reaction and chemiluminescent detection identified that both brothers had different degrees of mosaicism for the CGG expansion. Large expansions amounting to 70% of the total were visible in the proband, whereas less than 5% of the signal was larger than the premutation in his mildly affected brother. These findings suggest that mosaicism may be responsible for some of the variation in penetrance in this disorder. 19 refs., 3 figs.

  18. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  19. Sister chromatid separation: falling apart at the seams.

    PubMed

    Cohen-Fix, O

    2000-11-16

    Cohesion between sister chromatids must be dissolved at the time of chromosome segregation. Recent studies reveal that the principles of cohesion dissolution in mitosis and meiosis are the same, but that there are important differences that stem from the distinct natures of these two processes.

  20. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... at the Marine Safety Center or in the files of the cognizant OCMI; (2) The owner of the plans... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100...

  1. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... vessel, provided: (1) Approved plans for the original vessel are on file at the Marine Safety Center or.... (b) If approved plans for original vessel are not on file at the Marine Safety Center (MSC) or with... 46 Shipping 4 2012-10-01 2012-10-01 false Plans for sister vessels. 116.210 Section...

  2. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... at the Marine Safety Center or in the files of the cognizant OCMI; (2) The owner of the plans... 46 Shipping 7 2014-10-01 2014-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100...

  3. Analysis of meiotic sister chromatid cohesion in Caenorhabditis elegans

    PubMed Central

    Severson, Aaron F.

    2016-01-01

    In sexually reproducing organisms, the formation of healthy gametes (sperm and eggs) requires the proper establishment and release of meiotic sister chromatid cohesion (SCC). SCC tethers replicated sisters from their formation in premeiotic S phase until the stepwise removal of cohesion in anaphase of meiosis I and II allows the separation of homologs and then sisters. Defects in the establishment or release of meiotic cohesion cause chromosome segregation errors that lead to the formation of aneuploid gametes and inviable embryos. The nematode Caenorhabditis elegans is an excellent model for studies of meiotic sister chromatid cohesion due to its genetic tractability and the excellent cytological properties of the hermaphrodite gonad. Moreover, mutants defective in the establishment or maintenance of meiotic SCC nevertheless produce abundant gametes, allowing analysis of the pattern of chromosome segregation. Here I will describe two approaches for analysis of meiotic cohesion in C. elegans. The first approach relies on cytology to detect and quantify defects in SCC. The second approach relies on PCR and restriction digests to identify embryos that inherited an incorrect complement of chromosomes due to aberrant meiotic chromosome segregation. Both approaches are sensitive enough to identify rare errors and precise enough to reveal distinctive phenotypes resulting from mutations that perturb meiotic SCC in different ways. The robust, quantitative nature of these assays should strengthen phenotypic comparisons of different meiotic mutants and enhance the reproducibility of data generated by different investigators. PMID:27797074

  4. Sister chromatid resolution: a cohesin releasing network and beyond.

    PubMed

    Shintomi, Keishi; Hirano, Tatsuya

    2010-10-01

    When chromosomes start to assemble in mitotic prophase, duplicated chromatids are not discernible within each chromosome. As condensation proceeds, they gradually show up, culminating in two rod-shaped structures apposed along their entire length within a metaphase chromosome. This process, known as sister chromatid resolution, is thought to be a prerequisite for rapid and synchronous separation of sister chromatids in anaphase. From a mechanistic point of view, the resolution process can be dissected into three distinct steps: (1) release of cohesin from chromosome arms; (2) formation of chromatid axes mediated by condensins; and (3) untanglement of inter-sister catenation catalyzed by topoisomerase II (topo II). In this review article, we summarize recent progress in our understanding the molecular mechanisms of sister chromatid resolution with a major focus on its first step, cohesin release. An emerging idea is that this seemingly simple step is regulated by an intricate network of positive and negative factors, including cohesin-binding proteins and mitotic kinases. Interestingly, some key factors responsible for cohesin release in early mitosis also play important roles in controlling cohesin functions during interphase. Finally, we discuss how the step of cohesin release might mechanistically be coordinated with the actions of condensins and topo II.

  5. Constructing and enacting kinship in sister-to-sister egg donation families: a multi-family member interview study.

    PubMed

    Van Parys, Hanna; Provoost, Veerle; Zeiler, Kristin; De Sutter, Petra; Pennings, Guido; Buysse, Ann

    2016-12-05

    Although intra-familial egg donation has been practiced for more than 15 years in several countries, little is known about family relationships in this family type. Framed within the new kinship studies, this article focuses on the experiential dimension of kinship in sister-to-sister egg donation families: how is kinship 'unpacked' and 'reconstructed' in this specific family constellation? Qualitative data analysis of interviews with receiving parents, their donating sisters and the donor children revealed six themes: (1) being connected as an extended family; (2) disambiguating motherhood; (3) giving and receiving as structuring processes; (4) acknowledging and managing the 'special' link between donor and child; (5) making sense of the union between father and donor; and (6) kinship constructions being challenged. This study showed the complex and continuous balancing of meanings related to the mother-child dyad, the donor-child dyad and the donor-father dyad. What stood out was the complexity of, on the one hand cherishing the genetic link with the child allowed by the sisters' egg donation, while, on the other, managing the meanings related to this link, by, for instance, acknowledging, downsizing, symbolising, and differentiating it from the mother-child bond. (A Virtual Abstract of this paper can be accessed at: https://www.youtube.com/channel/UC_979cmCmR9rLrKuD7z0ycA).

  6. Microcephaly-capillary malformation syndrome: Brothers with a homozygous STAMBP mutation, uncovered by exome sequencing.

    PubMed

    Naseer, Muhammad Imran; Sogaty, Sameera; Rasool, Mahmood; Chaudhary, Adeel G; Abutalib, Yousif Ahmed; Walker, Susan; Marshall, Christian R; Merico, Daniele; Carter, Melissa T; Scherer, Stephen W; Al-Qahtani, Mohammad H; Zarrei, Mehdi

    2016-11-01

    We describe two brothers from a consanguineous family of Egyptian ancestry, presenting with microcephaly, apparent global developmental delay, seizures, spasticity, congenital blindness, and multiple cutaneous capillary malformations. Through exome sequencing, we uncovered a homozygous missense variant in STAMBP (p.K303R) in the two siblings, inherited from heterozygous carrier parents. Mutations in STAMBP are known to cause microcephaly-capillary malformation syndrome (MIC-CAP) and the phenotype in this family is consistent with this diagnosis. We compared the findings in the present brothers with those of earlier reported patients. © 2016 Wiley Periodicals, Inc.

  7. 76 FR 315 - Sisters Ranger District; Deschutes National Forest; Oregon; Popper Vegetation Management Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... comments-pacificnorthwest-deschutes-sisters@fs.fed.us . Please put ``Popper Vegetation Management Project... effects will take place. The Popper Vegetation Management Project decision and the reasons for the... Forest Service Sisters Ranger District; Deschutes National Forest; Oregon; Popper Vegetation...

  8. Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors

    PubMed Central

    Killoren, Sarah E.; Roach, Andrea L.

    2013-01-01

    Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls’ ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters’ similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843

  9. "Our Boys": The Christian Brothers and the Formation of Youth in the "New Ireland"1914-1944

    ERIC Educational Resources Information Center

    Keogh, Daire

    2015-01-01

    This essay investigates the development of the boys' magazine, "Our Boys," and how this became a powerful auxiliary to the Christian Brothers' work in schools. It championed the values that the Christian Brothers had propagated since their foundation in 1802. Often characterised as Celtic and Romantic, it was neither, but aimed at…

  10. 77 FR 46439 - Decision To Evaluate a Petition To Designate a Class of Employees From the Baker Brothers Site in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... HUMAN SERVICES Decision To Evaluate a Petition To Designate a Class of Employees From the Baker Brothers Site in Toledo, Ohio, To Be Included in the Special Exposure Cohort AGENCY: National Institute for... to evaluate a petition to designate a class of employees from the Bakers Brothers site in...

  11. Geologic map of Three Sisters volcanic cluster, Cascade Range, Oregon

    USGS Publications Warehouse

    Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.

    2012-01-01

    The cluster of glaciated stratovolcanoes called the Three Sisters—South Sister, Middle Sister, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North Sister (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle Sister (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South Sister is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South Sister, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist

  12. Severe complications in wound healing and fracture treatment in two brothers with congenital insensitivity to pain with anhidrosis.

    PubMed

    Rapp, Marion; Spiegler, Juliane; Härtel, Christoph; Gillessen-Kaesbach, Gabrielle; Kaiser, Martin M

    2013-01-01

    Congenital insensitivity to pain with anhidrosis is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene, which encodes the receptor for nerve growth factor. We report the clinical and radiological pitfalls in the diagnosis and treatment of two brothers, aged 5 and 8 years, with congenital insensitivity to pain with anhidrosis, the older brother having a proven NTRK1 mutation. In the neonatal period, both presented with recurrent episodes of fever of unknown origin, but their clinical problems changed later. In addition to severe mental retardation and self-harming behaviour, the older brother developed recurrent nonbacterial destructive infections of both the calcaneus and later the talus. No immunodeficiency was found. The younger brother had three complex fractures with a long history of healing problems: overwhelming production of callus, osteomyelitis and movement restrictions. He has less mental retardation than his older brother and shows no self-mutilation.

  13. Socio-Technical Systems Analysis and Manufacturing Technology: Addressing "Big Brother" and Computers in Blue-Collar Work.

    ERIC Educational Resources Information Center

    Taylor, James C.

    For more than 80 years, jobs in the United States have been designed by people for others. For most of these years, the experts in job design have placed the production technology above the job holder in importance. Since the 1950s, many jobs have been redesigned around new, computer-based technology. Often, the net effect has been to make those…

  14. Is Big Brother Watching You? The Evolving Role of the State in Regulating and Conducting Quality Assurance. CIQG Publication Series

    ERIC Educational Resources Information Center

    Salmi, Jamil

    2015-01-01

    A recent report published in the United Kingdom proposed the image of "an avalanche" to describe the radical changes affecting tertiary education in many parts of the world (Barber, Donnelly and Rizvi, 2013). Indeed, powerful transformative forces of three kinds--rupture factors, crisis factors and stimulus factors--are challenging…

  15. The Irish Christian Brothers and the National Board of Education: Challenging the Myths

    ERIC Educational Resources Information Center

    McLaughlin, Denis

    2008-01-01

    For close to 170 years the general consensus from historians has been that Edmund Rice, who founded the Irish Christian Brothers in 1802, was an unenthusiastic applicant to the National Board of Education in Ireland in 1832 and later withdrew his schools because he believed his education was incompatible with the philosophy underpinning the…

  16. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  17. A Thousand Lights [and] A Thousand Lights: Teacher and Parent Guide. Brothers Series.

    ERIC Educational Resources Information Center

    Benton, Hope

    This book for children (ages 8 to 14) and the accompanying teacher/parent guide present the story of two brothers, one of whom has a severe hearing impairment, who climb up Mt. Fuji in Japan. Information on the disability is presented subtly and incidentally to encourage the reader to relate more personally and foster a deeper level of acceptance…

  18. 3 CFR 8918 - Proclamation 8918 of December 17, 2012. Wright Brothers Day, 2012

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... December 17, 2012 Proc. 8918 Wright Brothers Day, 2012By the President of the United States of America A... example inspired the kind of businesses and industries that built and grew our middle class. As we mark... requested the President to issue annually a proclamation inviting the people of the United States to...

  19. Another Look at Vividness in the Trial of Two Vietnamese Brothers.

    ERIC Educational Resources Information Center

    Bresnahan, Mary I.

    A study examined the trial of People v. Tien (two Vietnamese brothers named defendants in an assault case). In order to understand better the relationship between supportive speech acts and credibility, the study examined how the attorney elicited vivid testimony. One of the ways in which an attorney yields control of testimony to a witness is by…

  20. The Wright Brothers and the Future of Bio-Inspired Flight: 1899 through to the Future

    NASA Technical Reports Server (NTRS)

    Bowers, Albion

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that proceeded the first powered flight.

  1. The Role of Digital Literacy Practices on Refugee Resettlement: The Case of Three Karen Brothers

    ERIC Educational Resources Information Center

    Gilhooly, Daniel; Lee, Eunbae

    2014-01-01

    This study explores the social and cultural uses of digital literacies by adolescent immigrants to cope with their new lives in the United States. This case study focuses on three adolescent ethnic Karen brothers. Two years of participant observations in their home and Karen community, accompanied by formal and informal interviews, served as the…

  2. Sibling Communication in "Star Trek: The Next Generation": Conflicts between Brothers.

    ERIC Educational Resources Information Center

    Fuss-Reineck, Marilyn

    "Star Trek: The Next Generation" depicts sibling relationships between Data and Lore (android), Worf and Kurn (Klingon) and Jean-Luc and Robert (human) that illustrate conflictual communication and suggest teaching applications. The most disturbing empirical communication research on conflict between brothers reports that male sibling…

  3. Brothers in Excellence: An Empowerment Model for the Career Development of African American Boys

    ERIC Educational Resources Information Center

    Grimmett, Marc A.

    2010-01-01

    The author describes Brothers in Excellence (BE), a conceptual model for understanding African American boys and helping them to be successful. BE addresses 3 domains of development proposed to be essential to the success of all African American boys: identity development, social development, and career development. (Contains 1 figure.)

  4. Evidence of environmental suppression of familial resemblance: height among US Civil War brothers.

    PubMed

    Lauderdale, D S; Rathouz, P J

    1999-01-01

    This study examines, with historical data, whether within family correlations in height varied across environments and whether variability in height was greater in worse environments. To investigate these hypotheses, brothers were identified who were mustered into the Union Army of the US Civil War, using linked records from the 1850 and 1860 censuses and military and medical records. Heights were available for 3898 men aged 18 and older, of whom 595 were further identified as belonging to 288 family sets of two, three or four brothers. Generalized estimating equations were used to concurrently model the mean height, the variance and the correlation between brothers as a function of county population. Heights decreased as county population size increased (p<0.001). The correlation between brothers' heights decreased significantly (p = 0.032) with increasing county population, and the variance increased (p = 0.026). The correlation ranged approximately from 0.63 in the least populous to 0.24 in the most populous counties. The degree of familial resemblance was lower in environments where mean height was lower, and the variability in height was greater, suggesting that the environmental contribution to the variability in height is of greater relative importance in populations reared, on average, in worse environments.

  5. Two Brothers, Two Cities: Music Education in Boston and Cincinnati from 1830-1844

    ERIC Educational Resources Information Center

    Lenzo, Terri Brown; Resta, Craig

    2011-01-01

    The birth of American music education is often attributed solely to Lowell Mason in Boston. His younger brother Timothy, however, was also active at the same time in Cincinnati. This study traces the roots of music education in both cities, but highlights the rarely cited accomplishments of Timothy Mason and his colleagues. Using historical…

  6. Brief Report: Comparative ABA and DIR Trials in Twin Brothers with Autism

    ERIC Educational Resources Information Center

    Hilton, Jane C.; Seal, Brenda C.

    2007-01-01

    Trial interventions in DIR and ABA with twin brothers with autism were offered to help the parents choose one of the programs for their sons. Pre- and post-test scores on the Communication and Symbolic Behavior Scales (CSBS) revealed a slight gain in the composite score of the ABA child and a slight loss in the score of the DIR child. Contrasted…

  7. My Brother as "Problem": Neoliberal Governmentality and Interventions for Black Young Men and Boys

    ERIC Educational Resources Information Center

    Dumas, Michael J.

    2016-01-01

    In this article, the author argues that the Obama Administration's My Brother's Keeper (MBK) initiative serves as an exemplar of neoliberal governmentality, in which Black young men and boys are constructed as essentially damaged, as problems in need of a technocratic public--private solution. More than simply an ideological imposition from above…

  8. Circuits of Spectacle: The Miller Brothers' 101 Ranch Real Wild West

    ERIC Educational Resources Information Center

    Fields, Alison

    2012-01-01

    The Miller Brothers' 101 Ranch Real Wild West show ran from 1906 to 1931, outlasting the famous Buffalo Bill's Wild West show by more than a decade. From its beginnings in Oklahoma Territory, the Real Wild West show traveled national and international circuits and built a broad roster of performers, including more than 150 American Indians. During…

  9. Umbilical metastasis (Sister Joseph's nodule) from carcinoma of the vagina.

    PubMed

    Bakri, Y N; Subhi, J; Hashim, E; Senoussi, M

    1991-01-01

    A case is reported of a squamous cell carcinoma of the vagina with metastasis to the umbilicus (Sister Mary Joseph's nodule). Systemic cisplatinum chemotherapy resulted in partial response, however, the "nodule" was a sign of poor prognosis and indicative of short-term survival. To the best of our knowledge, this is the first report of umbilical metastasis from a primary carcinoma of the vagina.

  10. Southall Black Sisters. Hannana Siddiqui speaks to Rasna Warah.

    PubMed

    Warah, R

    1994-01-01

    Southall Black Sisters, an organization for Asian and Afro-Caribbean women in Great Britain, was established in 1979 at the height of anti-racist protests to address the otherwise neglected issue of women's oppression. The group has campaigned against discriminatory immigration laws, illegal virginity tests at Heathrow airport, domestic violence, and other issues of particular concern to British Asian women. Women who migrate to England for an arranged marriage must remain with their husband at least 1 year or face deportation and denial of any public assistance, placing them at risk of unreported domestic violence. Southall Black Sisters has attempted to raise the public consciousness about domestic violence as a criminal issue and garner support for Asian women who leave abusive husbands. However, no support has been forthcoming from the anti-racist movement, which fears that publicity on domestic violence will create a racist backlash against Asian men. More support has been available for the group's campaign to protect battered women who kill their husbands by removing from the law on provocation the need for an immediate response. Another campaign has involved protests against "bounty hunters" hired by Asian families to return girls who have escaped from arranged marriages in their home country or sexual abuse within their family. Southall Black Sisters attributes many of the problems faced by its clients to a rise in religious fundamentalism and Muslim attempts to reverse the gains of the feminist movement.

  11. [The umbilical metastasis. Sister Mary Joseph and her time].

    PubMed

    Trebing, D; Göring, H-D

    2004-02-01

    Although Baluff in 1854 and Nelaton in 1860 had already described umbilical metastases, the best known description of the metastasis of carcinomas to this site as "trouser button navel" was published in 1928 by William James Mayo (1861-1939), son of William Worrall Mayo (1815-1911), the founder of the Mayo Clinic in Rochester, Minnesota, This phenomenon is supposed to have been pointed out to Mayo by his long-serving head surgical nurse Sister Mary Joseph (1856-1939). The English surgeon Hamilton Bailey, in his famous textbook "Physical Signs in Clinical Surgery" in 1949, coined the term "Sister Joseph's nodule" for an umbilical metastasis. The expression has become widely accepted and used. Sister Mary Joseph, daughter of Irish immigrants, belonged to the 3rd order of the Holy Francis, was distinguished for her skills, intelligence and devotion to nursing which was also her calling. She worked for many decades at the world-famous Mayo Clinic and taught generations of young nurses. In recent years, the original surgical building at Saint Mary's Hospital has been named "Joseph Building" in her memory. Among the numerous eponyms occurring in the dermatology and the medicine, the association with the name of a nurse represents beyond doubt a special feature.

  12. Genomic sister-disorders of neurodevelopment: an evolutionary approach

    PubMed Central

    Crespi, Bernard; Summers, Kyle; Dorus, Steve

    2009-01-01

    Genomic sister-disorders are defined here as diseases mediated by duplications versus deletions of the same region. Such disorders can provide unique information concerning the genomic underpinnings of human neurodevelopment because effects of diametric variation in gene copy number on cognitive and behavioral phenotypes can be inferred. We describe evidence from the literature on deletions versus duplications for the regions underlying the best-known human neurogenetic sister-disorders, including Williams syndrome, Velocardiofacial syndrome, and Smith–Magenis syndrome, as well as the X-chromosomal conditions Klinefelter and Turner syndromes. These data suggest that diametric copy-number alterations can, like diametric alterations to imprinted genes, generate contrasting phenotypes associated with autistic-spectrum and psychotic-spectrum conditions. Genomically based perturbations to the development of the human social brain are thus apparently mediated to a notable degree by effects of variation in gene copy number. We also conducted the first analyses of positive selection for genes in the regions affected by these disorders. We found evidence consistent with adaptive evolution of protein-coding genes, or selective sweeps, for three of the four sets of sister-syndromes analyzed. These studies of selection facilitate identification of candidate genes for the phenotypes observed and lend a novel evolutionary dimension to the analysis of human cognitive architecture and neurogenetic disorders. PMID:25567849

  13. Broad phylogenomic sampling and the sister lineage of land plants.

    PubMed

    Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F

    2012-01-01

    The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae.

  14. The big deal about big data.

    PubMed

    Moore, Keith D; Eyestone, Katherine; Coddington, Dean C

    2013-08-01

    Big data is a concept that is being widely applied in the retail industries as a means to understand customers' purchasing habits and preferences for followup promotional activity. It is characterized by vast amounts of diverse and rapidly multiplying data that are available at or near real-time. Conversations with executives of leading healthcare organizations provide a barometer for understanding where the industry stands in its adoption of big data as a means to meet the critical information requirements of value-based health care.

  15. Dual of big bang and big crunch

    SciTech Connect

    Bak, Dongsu

    2007-01-15

    Starting from the Janus solution and its gauge theory dual, we obtain the dual gauge theory description of the cosmological solution by the procedure of double analytic continuation. The coupling is driven either to zero or to infinity at the big-bang and big-crunch singularities, which are shown to be related by the S-duality symmetry. In the dual Yang-Mills theory description, these are nonsingular as the coupling goes to zero in the N=4 super Yang-Mills theory. The cosmological singularities simply signal the failure of the supergravity description of the full type IIB superstring theory.

  16. Implementing Big History.

    ERIC Educational Resources Information Center

    Welter, Mark

    2000-01-01

    Contends that world history should be taught as "Big History," a view that includes all space and time beginning with the Big Bang. Discusses five "Cardinal Questions" that serve as a course structure and address the following concepts: perspectives, diversity, change and continuity, interdependence, and causes. (CMK)

  17. Big data for health.

    PubMed

    Andreu-Perez, Javier; Poon, Carmen C Y; Merrifield, Robert D; Wong, Stephen T C; Yang, Guang-Zhong

    2015-07-01

    This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of big data and how medical and health informatics, translational bioinformatics, sensor informatics, and imaging informatics will benefit from an integrated approach of piecing together different aspects of personalized information from a diverse range of data sources, both structured and unstructured, covering genomics, proteomics, metabolomics, as well as imaging, clinical diagnosis, and long-term continuous physiological sensing of an individual. It is expected that recent advances in big data will expand our knowledge for testing new hypotheses about disease management from diagnosis to prevention to personalized treatment. The rise of big data, however, also raises challenges in terms of privacy, security, data ownership, data stewardship, and governance. This paper discusses some of the existing activities and future opportunities related to big data for health, outlining some of the key underlying issues that need to be tackled.

  18. Nonrandom sister chromatid segregation of sex chromosomes in Drosophila male germline stem cells.

    PubMed

    Yamashita, Yukiko M

    2013-05-01

    Sister chromatids are the product of DNA replication, which is assumed to be a very precise process. Therefore, sister chromatids should be exact copies of each other. However, reports have indicated that sister chromatids are segregated nonrandomly during cell division, suggesting that sister chromatids are not the same, although their DNA sequences are the same. Researchers have speculated that stem cells may retain template strands to avoid replication-induced mutations. An alternative proposal is that cells may segregate distinct epigenetic information carried on sister chromatids. Recently, we found that Drosophila male germline stem cells segregate sister chromatids of X and Y chromosomes with a strong bias. We discuss this finding in relation to existing models for nonrandom sister chromatid segregation.

  19. Big data, big knowledge: big data for personalized healthcare.

    PubMed

    Viceconti, Marco; Hunter, Peter; Hose, Rod

    2015-07-01

    The idea that the purely phenomenological knowledge that we can extract by analyzing large amounts of data can be useful in healthcare seems to contradict the desire of VPH researchers to build detailed mechanistic models for individual patients. But in practice no model is ever entirely phenomenological or entirely mechanistic. We propose in this position paper that big data analytics can be successfully combined with VPH technologies to produce robust and effective in silico medicine solutions. In order to do this, big data technologies must be further developed to cope with some specific requirements that emerge from this application. Such requirements are: working with sensitive data; analytics of complex and heterogeneous data spaces, including nontextual information; distributed data management under security and performance constraints; specialized analytics to integrate bioinformatics and systems biology information with clinical observations at tissue, organ and organisms scales; and specialized analytics to define the "physiological envelope" during the daily life of each patient. These domain-specific requirements suggest a need for targeted funding, in which big data technologies for in silico medicine becomes the research priority.

  20. Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations

    PubMed Central

    Hall, Julie M.; Georgiades, Matthew J.; Hammond, Deborah A.; Feng, Xiaoting; Moustafa, Ahmed A.; Todd, Gabrielle

    2017-01-01

    We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD. PMID:28168069

  1. Big Data in industry

    NASA Astrophysics Data System (ADS)

    Latinović, T. S.; Preradović, D. M.; Barz, C. R.; Latinović, M. T.; Petrica, P. P.; Pop-Vadean, A.

    2016-08-01

    The amount of data at the global level has grown exponentially. Along with this phenomena, we have a need for a new unit of measure like exabyte, zettabyte, and yottabyte as the last unit measures the amount of data. The growth of data gives a situation where the classic systems for the collection, storage, processing, and visualization of data losing the battle with a large amount, speed, and variety of data that is generated continuously. Many of data that is created by the Internet of Things, IoT (cameras, satellites, cars, GPS navigation, etc.). It is our challenge to come up with new technologies and tools for the management and exploitation of these large amounts of data. Big Data is a hot topic in recent years in IT circles. However, Big Data is recognized in the business world, and increasingly in the public administration. This paper proposes an ontology of big data analytics and examines how to enhance business intelligence through big data analytics as a service by presenting a big data analytics services-oriented architecture. This paper also discusses the interrelationship between business intelligence and big data analytics. The proposed approach in this paper might facilitate the research and development of business analytics, big data analytics, and business intelligence as well as intelligent agents.

  2. Two novel mutations on exon 8 and intron 65 of COL7A1 gene in two Chinese brothers result in recessive dystrophic epidermolysis bullosa.

    PubMed

    Lin, Ying; Chen, Xue-Jun; Liu, Wei; Gong, Bo; Xie, Jun; Xiong, Jun-Hao; Cheng, Jing; Duan, Xi-Ling; Lin, Zhao-Chun; Huang, Lu-Lin; Wan, Hui-Ying; Liu, Xiao-Qi; Song, Lin-Hong; Yang, Zheng-Lin

    2012-01-01

    Dystrophic epidermolysis bullosa is an inherited bullous dermatosis caused by the COL7A1 gene mutation in autosomal dominant or recessive mode. COL7A1 gene encodes type VII collagen - the main component of the anchoring fibrils at the dermal-epidermal junction. Besides the 730 mutations reported, we identified two novel COL7A1 gene mutations in a Chinese family, which caused recessive dystrophic epidermolysis bullosa (RDEB). The diagnosis was established histopathologically and ultrastructurally. After genomic DNA extraction from the peripheral blood sample of all subjects (5 pedigree members and 136 unrelated control individuals), COL7A1 gene screening was performed by polymerase chain reaction amplification and direct DNA sequencing of the whole coding exons and flanking intronic regions. Genetic analysis of the COL7A1 gene in affected individuals revealed compound heterozygotes with identical novel mutations. The maternal mutation is a 2-bp deletion at exon 8 (c.1006_1007delCA), leading to a subsequent reading frame-shift and producing a premature termination codon located 48 amino acids downstream in exon 9 (p.Q336EfsX48), consequently resulting in the truncation of 2561 amino acids downstream. This was only present in two affected brothers, but not in the other unaffected family members. The paternal mutation is a 1-bp deletion occurring at the first base of intron 65 (c.IVS5568+1delG) that deductively changes the strongly conserved GT dinucleotide at the 5' donor splice site, results in subsequent reading-through into intron 65, and creates a stop codon immediately following the amino acids encoded by exon 65 (GTAA→TAA). This is predicted to produce a truncated protein lacking of 1089 C-terminal amino acids downstream. The latter mutation was found in all family members except one of the two unaffected sisters. Both mutations were observed concurrently only in the two affected brothers. Neither mutation was discovered in 136 unrelated Chinese control

  3. The Big Bang Theory

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The Big Bang is the name of the most respected theory of the creation of the universe. Basically, the theory says that the universe was once smaller and denser and has been expending for eons. One common misconception is that the Big Bang theory says something about the instant that set the expansion into motion, however this isn’t true. In this video, Fermilab’s Dr. Don Lincoln tells about the Big Bang theory and sketches some speculative ideas about what caused the universe to come into existence.

  4. The Big Bang Theory

    SciTech Connect

    Lincoln, Don

    2014-09-30

    The Big Bang is the name of the most respected theory of the creation of the universe. Basically, the theory says that the universe was once smaller and denser and has been expending for eons. One common misconception is that the Big Bang theory says something about the instant that set the expansion into motion, however this isn’t true. In this video, Fermilab’s Dr. Don Lincoln tells about the Big Bang theory and sketches some speculative ideas about what caused the universe to come into existence.

  5. What's in a Relationship? An Examination of Social Capital, Race and Class in Mentoring Relationships

    ERIC Educational Resources Information Center

    Gaddis, S. Michael

    2012-01-01

    After 25 years of intense scrutiny, social capital remains an important yet highly debated concept in social science research. This research uses data from youth and mentors in several chapters of Big Brothers/Big Sisters to assess the importance of different mentoring relationship characteristics in creating positive outcomes among youths. The…

  6. Culture, Context, and Innovation: A Kiwi Canuck Perspective

    ERIC Educational Resources Information Center

    Marshall, Dave; Shaver, Karen

    2010-01-01

    This commentary lends a global practitioner perspective on the utility of this volume to the efforts of mentors and mentees and mentoring program developers. Dave Marshall and Karen Shaver, of Big Brothers Big Sisters New Zealand and Canada, respectively, offer keen insights into the value of creating a shared language for discussing mentoring…

  7. School-Based Mentoring. A Closer Look

    ERIC Educational Resources Information Center

    Herrera, Carla

    2004-01-01

    With traditional mentoring programs working hard to attract new kinds of volunteers and schools facing increased pressure to help students succeed, school-based mentoring is a promising--and increasingly popular--approach. According to Big Brothers Big Sisters of America, the number of school-based matches grew from 27,000 in 1999 to 90,000 in…

  8. School-Based Mentoring Programs: Using Volunteers to Improve the Academic Outcomes of Underserved Students

    ERIC Educational Resources Information Center

    Bayer, Amanda; Grossman, Jean Baldwin; DuBois, David L.

    2013-01-01

    Previous research suggests that school-based mentoring programs like those offered by Big Brothers Big Sisters of America (BBBSA) yield small but statistically significant improvements in the academic performance of mentored students and in their beliefs in their own scholastic efficacy. The present study uses data from a randomized control trial…

  9. High School Teen Mentoring Handbook

    ERIC Educational Resources Information Center

    Alberta Advanced Education and Technology, 2009

    2009-01-01

    Big Brothers Big Sisters Edmonton & Area, in partnership with Alberta Advanced Education and Technology, are providing the High School Teen Mentoring Program, a school-based mentoring program where mentor-mentee matches meet for one hour per week to engage in relationship-building activities at an elementary school. This initiative aims to…

  10. Review of Three Recent Randomized Trials of School-Based Mentoring: Making Sense of Mixed Findings. Social Policy Report. Volume 24, Number 3

    ERIC Educational Resources Information Center

    Wheeler, Marc E.; Keller, Thomas E.; DuBois, David L.

    2010-01-01

    Between 2007 and 2009, reports were released on the results of three separate large-scale random assignment studies of the effectiveness of school-based mentoring programs for youth. The studies evaluated programs implemented by Big Brothers Big Sisters of America (BBBSA) affiliates (Herrera et al., 2007), Communities In Schools of San Antonio,…

  11. Meeting the Challenge of Doing an RCT Evaluation of Youth Mentoring in Ireland: A Journey in Mixed Methods

    ERIC Educational Resources Information Center

    Brady, Bernadine; O'Regan, Connie

    2009-01-01

    The youth mentoring program Big Brothers Big Sisters is one of the first social interventions involving youth in Ireland to be evaluated using a randomized controlled trial methodology. This article sets out the design process undertaken, describing how the research team came to adopt a concurrent embedded mixed methods design as a means of…

  12. The Impact of School-Based Mentoring on Youths with Different Relational Profiles

    ERIC Educational Resources Information Center

    Schwartz, Sarah E. O.; Rhodes, Jean E.; Chan, Christian S.; Herrera, Carla

    2011-01-01

    Associations between youths' relationship profiles and mentoring outcomes were explored in the context of a national, randomized study of 1,139 youths (54% female) in geographically diverse Big Brothers Big Sisters school-based mentoring programs. The sample included youths in Grades 4-9 from diverse racial and ethnic backgrounds, the majority of…

  13. Finding Fortune in Thirteen Out-of-School Time Programs: A Compendium of Education Programs and Practices.

    ERIC Educational Resources Information Center

    Trammel, Ming

    This research compendium summarizes and reviews the evaluations of 13 out-of-school time programs with positive outcomes for young people. The programs are (1) 4-H; (2) 21st Century Community Learning Centers; (3) The After-School Corporation; (4) Beacons; (5) BELL After School Instructional Curriculum; (6) Big Brothers Big Sisters of America; (7)…

  14. FtsK actively segregates sister chromosomes in Escherichia coli.

    PubMed

    Stouf, Mathieu; Meile, Jean-Christophe; Cornet, François

    2013-07-02

    Bacteria use the replication origin-to-terminus polarity of their circular chromosomes to control DNA transactions during the cell cycle. Segregation starts by active migration of the region of origin followed by progressive movement of the rest of the chromosomes. The last steps of segregation have been studied extensively in the case of dimeric sister chromosomes and when chromosome organization is impaired by mutations. In these special cases, the divisome-associated DNA translocase FtsK is required. FtsK pumps chromosomes toward the dif chromosome dimer resolution site using polarity of the FtsK-orienting polar sequence (KOPS) DNA motifs. Assays based on monitoring dif recombination have suggested that FtsK acts only in these special cases and does not act on monomeric chromosomes. Using a two-color system to visualize pairs of chromosome loci in living cells, we show that the spatial resolution of sister loci is accurately ordered from the point of origin to the dif site. Furthermore, ordered segregation in a region ∼200 kb long surrounding dif depended on the oriented translocation activity of FtsK but not on the formation of dimers or their resolution. FtsK-mediated segregation required the MatP protein, which delays segregation of the dif-surrounding region until cell division. We conclude that FtsK segregates the terminus region of sister chromosomes whether they are monomeric or dimeric and does so in an accurate and ordered manner. Our data are consistent with a model in which FtsK acts to release the MatP-mediated cohesion and/or interaction with the division apparatus of the terminus region in a KOPS-oriented manner.

  15. Agenesis of the Gallbladder in Monozygotic Twin Sisters

    PubMed Central

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed “gallbladder agenesis.” Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274

  16. Agenesis of the Gallbladder in Monozygotic Twin Sisters.

    PubMed

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed "gallbladder agenesis." Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality.

  17. District nursing sister attached to hospital surgical department.

    PubMed

    Hockey, L

    1970-04-18

    An experiment of attaching a district nursing sister to the surgical department of a general hospital was designed to show the use of the district nursing service for the after-care of patients discharged from hospital after surgical treatment. In a 15-week period about 590 bed days were saved, and only six out of 126 patients discharged early had to be readmitted. Most of the patients and the general practitioners who replied to questionaries about the scheme were in favour of it.

  18. Catholic Sister Nurses in Selma, Alabama, 1940–1972

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  19. Thinking big thoughts

    NASA Astrophysics Data System (ADS)

    Vedral, Vlatko

    2016-08-01

    The short synopsis of The Big Picture by Sean Carroll is that it explores the question of whether science can explain everything in the world, and analyses the emerging reality that such an explanation entails.

  20. The Big Bang Singularity

    NASA Astrophysics Data System (ADS)

    Ling, Eric

    The big bang theory is a model of the universe which makes the striking prediction that the universe began a finite amount of time in the past at the so called "Big Bang singularity." We explore the physical and mathematical justification of this surprising result. After laying down the framework of the universe as a spacetime manifold, we combine physical observations with global symmetrical assumptions to deduce the FRW cosmological models which predict a big bang singularity. Next we prove a couple theorems due to Stephen Hawking which show that the big bang singularity exists even if one removes the global symmetrical assumptions. Lastly, we investigate the conditions one needs to impose on a spacetime if one wishes to avoid a singularity. The ideas and concepts used here to study spacetimes are similar to those used to study Riemannian manifolds, therefore we compare and contrast the two geometries throughout.

  1. Big data need big theory too.

    PubMed

    Coveney, Peter V; Dougherty, Edward R; Highfield, Roger R

    2016-11-13

    The current interest in big data, machine learning and data analytics has generated the widespread impression that such methods are capable of solving most problems without the need for conventional scientific methods of inquiry. Interest in these methods is intensifying, accelerated by the ease with which digitized data can be acquired in virtually all fields of endeavour, from science, healthcare and cybersecurity to economics, social sciences and the humanities. In multiscale modelling, machine learning appears to provide a shortcut to reveal correlations of arbitrary complexity between processes at the atomic, molecular, meso- and macroscales. Here, we point out the weaknesses of pure big data approaches with particular focus on biology and medicine, which fail to provide conceptual accounts for the processes to which they are applied. No matter their 'depth' and the sophistication of data-driven methods, such as artificial neural nets, in the end they merely fit curves to existing data. Not only do these methods invariably require far larger quantities of data than anticipated by big data aficionados in order to produce statistically reliable results, but they can also fail in circumstances beyond the range of the data used to train them because they are not designed to model the structural characteristics of the underlying system. We argue that it is vital to use theory as a guide to experimental design for maximal efficiency of data collection and to produce reliable predictive models and conceptual knowledge. Rather than continuing to fund, pursue and promote 'blind' big data projects with massive budgets, we call for more funding to be allocated to the elucidation of the multiscale and stochastic processes controlling the behaviour of complex systems, including those of life, medicine and healthcare.This article is part of the themed issue 'Multiscale modelling at the physics-chemistry-biology interface'.

  2. Big data need big theory too

    PubMed Central

    Dougherty, Edward R.; Highfield, Roger R.

    2016-01-01

    The current interest in big data, machine learning and data analytics has generated the widespread impression that such methods are capable of solving most problems without the need for conventional scientific methods of inquiry. Interest in these methods is intensifying, accelerated by the ease with which digitized data can be acquired in virtually all fields of endeavour, from science, healthcare and cybersecurity to economics, social sciences and the humanities. In multiscale modelling, machine learning appears to provide a shortcut to reveal correlations of arbitrary complexity between processes at the atomic, molecular, meso- and macroscales. Here, we point out the weaknesses of pure big data approaches with particular focus on biology and medicine, which fail to provide conceptual accounts for the processes to which they are applied. No matter their ‘depth’ and the sophistication of data-driven methods, such as artificial neural nets, in the end they merely fit curves to existing data. Not only do these methods invariably require far larger quantities of data than anticipated by big data aficionados in order to produce statistically reliable results, but they can also fail in circumstances beyond the range of the data used to train them because they are not designed to model the structural characteristics of the underlying system. We argue that it is vital to use theory as a guide to experimental design for maximal efficiency of data collection and to produce reliable predictive models and conceptual knowledge. Rather than continuing to fund, pursue and promote ‘blind’ big data projects with massive budgets, we call for more funding to be allocated to the elucidation of the multiscale and stochastic processes controlling the behaviour of complex systems, including those of life, medicine and healthcare. This article is part of the themed issue ‘Multiscale modelling at the physics–chemistry–biology interface’. PMID:27698035

  3. Brotherly Advice: Letters from Hugo to Paul Ehrenfest in his Final Years

    NASA Astrophysics Data System (ADS)

    Halpern, Paul

    2006-03-01

    At the start of the 1930s, theoretician Paul Ehrenfest spent much of his time traveling through America and Europe while engaged in a steady stream of lectures. This traveling phase coincided with a frantic and intense period of negative self-examination, financial difficulty, and various other personal concerns that would ultimately lead to his 1933 suicide. Throughout these final years, he kept up a steady correspondence with his brother Hugo, a physician based in Saint Louis. Ten years older than Paul, Hugo freely doled out frank psychological advice about subjects ranging from the proper treatment of children to the dangers of self-pity. Through a look at some of the letters exchanged between the two brothers, this talk will examine the role Hugo played during the dark final years of Paul Ehrenfest's life.

  4. Dr. Max King: the sad life and early death of Mackenzie King's physician brother

    PubMed Central

    Gray, C

    1998-01-01

    While researching her best-selling biography, Mrs. King: The Life and Times of Isabel Mackenzie King, CMAJ contributing editor Charlotte Gray discovered a wealth of information about Dr. Dougal Macdougall (Max) King. Although he never became as famous as his older brother Mackenzie, Gray presents a convincing argument that Dr. Max King's life and early death speak volumes about medicine and the medical profession at the turn of the century. She also argues that Mackenzie King's own life would have been much different had his brother not died at the too young age of 42. Gray's book was nominated for the Viacom Award, which honours the best nonfiction book published annually in Canada. PMID:9580741

  5. Learning to Fly: The Wright Brothers' Adventure. A Guide for Educators and Students with Activities in Aeronautics

    NASA Technical Reports Server (NTRS)

    Storm, R.; Benson, T.; Galica, C.; McCredie, P.

    2003-01-01

    This guide was produced by the NASA Glenn Research Center Office of Educational Programs in Cleveland, OH, and the NASA Aerospace Educational Coordinating Committee. It includes activity modules for students, including the history of the Wright Brothers and their family in Dayton, Ohio and flight experimentation in Kitty Hawk, North Carolina. Student activities such as building models of the Wright Brothers glider and writing press releases of the initial flight are included.

  6. Renal tubular dysgenesis, absent nipples, and multiple malformations in three brothers: a new, lethal syndrome.

    PubMed

    Hisama, F M; Reyes-Mugica, M; Wargowski, D S; Thompson, K J; Mahoney, M J

    1998-12-04

    We report on three brothers with renal tubular dysgenesis and absent nipples, each also had other malformations including pre-auricular pits and a preauricular tag, branchial clefts, choanal atresia, pulmonary lobation anomaly, ventricular septal defect, type IIB interrupted aortic arch, absent gallbladder, absent thymus, parathyroid gland, accessory spleen, imperforate anus, clinodactyly, and broad digits and small nails. All three infants died neonatally. This pattern of clinical malformations appears to be a previously unreported syndrome.

  7. Chromosome breakage and sister chromatid exchange analysis in computer operators

    SciTech Connect

    Butler, M.G.; Yost, J.; Jenkins, B.B.

    1987-01-01

    Chromosome breakage analysis with Mitomycin C (MMC) and sister chromatid exchanges (SCE) were obtained on 10 computer operators with computer exposure for a minimum of 3 hours per day for 4 years and 10 control subjects matched for age and personal lifestyle. No difference was found between the two groups in the total number of chromatid and chromosome aberrations in cells grown at 48 and/or 96 hours in Mitomycin C (20 or 50 ng/ml-final concentration). The average number of SCE per cell in approximately 30 cells from each person was 6.4 +/- 1.1 (mean +/- standard deviation) for the computer operators and 9.2 +/- 1.6 for the controls. This difference was significant (p < .001). The replicative index was significantly higher (p < .01) in computer operators than in control subjects. The number of SCE appeared not to be influenced by the years of computer exposure. Additional studies with larger sample sizes will be needed to identify if significant differences exist in cell kinetics and sister chromatid exchanges in individuals employed as computer operators.

  8. Narcolepsy with Cataplexy Mimicry: The Strange Case of Two Sisters

    PubMed Central

    Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe

    2013-01-01

    We report on two sisters, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyo-graphic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases. Citation: Pizza F; Vandi S; Poli F; Moghadam KK; Fran-ceschini C; Bellucci C; Cipolli C; Ingravallo F; Natalini G; Mignot E; Plazzi G. Narcolepsy with cataplexy mimicry: the strange case of two sisters. J Clin Sleep Med 2013;9(6):611-612. PMID:23772196

  9. Big Bend sees big environmental push

    SciTech Connect

    Blankinship, S.

    2007-10-15

    The 1800 MW Big Bend Power Station is a coal-fired facility in Tampa Bay, Florida, USA owned by Tampa Electric. It has four pulverized coal- fired steam units equipped with FGD scrubbers and electrostatic precipitators. Currently the addition of selective catalytic reduction (SCR) systems is under consideration. The Unit 4 SCR retrofit was completed in June 2007; the remaining three systems are scheduled for completion by 2010. Boiler draft systems will be modified to a balance draft design to accommodate the increased pressure drop of the new systems. 3-D computer models were developed to determine constructability due to the tight clearance at the site. 1 photo.

  10. Big data bioinformatics.

    PubMed

    Greene, Casey S; Tan, Jie; Ung, Matthew; Moore, Jason H; Cheng, Chao

    2014-12-01

    Recent technological advances allow for high throughput profiling of biological systems in a cost-efficient manner. The low cost of data generation is leading us to the "big data" era. The availability of big data provides unprecedented opportunities but also raises new challenges for data mining and analysis. In this review, we introduce key concepts in the analysis of big data, including both "machine learning" algorithms as well as "unsupervised" and "supervised" examples of each. We note packages for the R programming language that are available to perform machine learning analyses. In addition to programming based solutions, we review webservers that allow users with limited or no programming background to perform these analyses on large data compendia.

  11. Big data in biomedicine.

    PubMed

    Costa, Fabricio F

    2014-04-01

    The increasing availability and growth rate of biomedical information, also known as 'big data', provides an opportunity for future personalized medicine programs that will significantly improve patient care. Recent advances in information technology (IT) applied to biomedicine are changing the landscape of privacy and personal information, with patients getting more control of their health information. Conceivably, big data analytics is already impacting health decisions and patient care; however, specific challenges need to be addressed to integrate current discoveries into medical practice. In this article, I will discuss the major breakthroughs achieved in combining omics and clinical health data in terms of their application to personalized medicine. I will also review the challenges associated with using big data in biomedicine and translational science.

  12. Big Questions: Missing Antimatter

    ScienceCinema

    Lincoln, Don

    2016-07-12

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  13. Big Questions: Missing Antimatter

    SciTech Connect

    Lincoln, Don

    2013-08-27

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  14. Mercury poisoning in two 13-year-old twin sisters

    PubMed Central

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-01-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis. PMID:26109979

  15. Sister chromatid exchange in Polish White improved goats (Capra hircus).

    PubMed

    Wójcik, Ewa; Smalec, Elzbieta

    2012-01-01

    The study was aimed at evaluating the frequency of spontaneous sister chromatid exchange in Polish White Improved goats (Capra hircus). The mean number of SCEs/cell was 2.73 +/- 1.84. The effect of sex and age on SCE incidence was also investigated. No statistically significant differences in the number of SCEs/cell were observed between the males and females. On the other hand, age was found to significantly influence SCE frequency. A lower SCE frequency was observed in younger goats. A positive correlation between chromosome length and SCE number was identified. The longer the chromosome, the more exchanges occurred. The highest number of SCEs was observed in the interstitial region, the lowest in the distal area.

  16. Increased levels of sister chromatid exchanges in military aircraft pilots.

    PubMed

    Silva, M J; Carothers, A; Castelo Branco, N; Dias, A; Boavida, M G

    1999-04-26

    Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-performance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SCEs (high-frequency cells, HFCs) revealed a significant difference between pilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no significant differences either between pilots and controls or between smokers and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibration. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man.

  17. Mercury poisoning in two 13-year-old twin sisters.

    PubMed

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-03-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis.

  18. Sister chromatid exchange, DNA repair, and single-gene mutation

    SciTech Connect

    Carrano, A.V.; Thompson, L.H.

    1982-01-01

    Sister chromatid exchange (SCE) has been studied in cultured mammalian cells with regard to the nature of the inducing lesion, mutation induction, and factors that modify the observed frequency following mutagen exposure, SCEs can be induced by a wide spectrum of DNA lesions and, for nine agents examined, the frequency of induced SCE is linearly related to induced single-gene mutation. Further, a deficiency in DNA repair may alter the expression of both SCE and mutation in a qualitatively similar manner. The frequency of SCE induced by mitomycin-C is suppressed in heterochromatic relative to euchromatin and, in nondividing lymphocytes, the lesions leading to the formation of SCEs may persist for several months.

  19. Sister Mary Joseph's nodule as initial pancreatic cancer manifestation.

    PubMed

    Vallejo Bernad, Cristina; Casamayor Franco, María Carmen; Hakim Alonso, Sofía

    2017-02-01

    We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis. Skin metastasis is a rare sign usually reflecting a carcinoma of unknown origin. Umbilical skin metastasis, called Sister Mary Joseph´s nodule, reflect an intra-abdominal tumor, being pancreatic cancer strange.

  20. Sisters in Science: Confronting Equity in Science and Mathematics Education

    NASA Astrophysics Data System (ADS)

    Hammrich, Penny L.; Richardson, Greer M.; Livingston, Beverly D.

    The Sisters in Science (SIS) program seeks to increase elementary school girls' interest and achievement in science and mathematics, create a more positive learning climate for minority school girls and their families on academic and community/social levels, and increase the knowledge base and understanding of parents with respect to their influence in promoting girls' interest and achievement in science and mathematics. This article reports on how 577 fourth grade girls changed their interest and achievement in science and mathematics during their involvement in year 1 of the program. Findings show that the girls started the program with positive attitudes and perceptions of science and about science career possibilities. The girls significantly (p < 0.001) increased their science and mathematics skill levels after having participated in the program. It could be stated that the girls' achievement scores on the skills test increased significantly because the girls' attitudes and perceptions were positive before program implementation.

  1. Youths' Caretaking of Their Adolescent Sisters' Children: Results from Two Longitudinal Studies

    ERIC Educational Resources Information Center

    East, Patricia L.; Weisner, Thomas S.; Slonim, Ashley

    2009-01-01

    The extent and experiences of youths' caretaking of their adolescent sisters' children have been assessed in two longitudinal studies. The first study examines the caretaking patterns of 132 Latino and African American youth during middle and late adolescence. The second study involves 110 Latino youth whose teenage sister has recently given…

  2. A Big Bang Lab

    ERIC Educational Resources Information Center

    Scheider, Walter

    2005-01-01

    The February 2005 issue of The Science Teacher (TST) reminded everyone that by learning how scientists study stars, students gain an understanding of how science measures things that can not be set up in lab, either because they are too big, too far away, or happened in a very distant past. The authors of "How Far are the Stars?" show how the…

  3. The Big Sky inside

    ERIC Educational Resources Information Center

    Adams, Earle; Ward, Tony J.; Vanek, Diana; Marra, Nancy; Hester, Carolyn; Knuth, Randy; Spangler, Todd; Jones, David; Henthorn, Melissa; Hammill, Brock; Smith, Paul; Salisbury, Rob; Reckin, Gene; Boulafentis, Johna

    2009-01-01

    The University of Montana (UM)-Missoula has implemented a problem-based program in which students perform scientific research focused on indoor air pollution. The Air Toxics Under the Big Sky program (Jones et al. 2007; Adams et al. 2008; Ward et al. 2008) provides a community-based framework for understanding the complex relationship between poor…

  4. Big Enough for Everyone?

    ERIC Educational Resources Information Center

    Coote, Anna

    2010-01-01

    The UK's coalition government wants to build a "Big Society." The Prime Minister says "we are all in this together" and building it is the responsibility of every citizen as well as every government department. The broad vision is welcome, but everything depends on how the vision is translated into policy and practice. The…

  5. The big bang

    NASA Astrophysics Data System (ADS)

    Silk, Joseph

    Our universe was born billions of years ago in a hot, violent explosion of elementary particles and radiation - the big bang. What do we know about this ultimate moment of creation, and how do we know it? Drawing upon the latest theories and technology, this new edition of The big bang, is a sweeping, lucid account of the event that set the universe in motion. Joseph Silk begins his story with the first microseconds of the big bang, on through the evolution of stars, galaxies, clusters of galaxies, quasars, and into the distant future of our universe. He also explores the fascinating evidence for the big bang model and recounts the history of cosmological speculation. Revised and updated, this new edition features all the most recent astronomical advances, including: Photos and measurements from the Hubble Space Telescope, Cosmic Background Explorer Satellite (COBE), and Infrared Space Observatory; the latest estimates of the age of the universe; new ideas in string and superstring theory; recent experiments on neutrino detection; new theories about the presence of dark matter in galaxies; new developments in the theory of the formation and evolution of galaxies; the latest ideas about black holes, worm holes, quantum foam, and multiple universes.

  6. A Sobering Big Idea

    ERIC Educational Resources Information Center

    Wineburg, Sam

    2006-01-01

    Since Susan Adler, Alberta Dougan, and Jesus Garcia like "big ideas," the author offers one to ponder: young people in this country can not read with comprehension. The saddest thing about this crisis is that it is no secret. The 2001 results of the National Assessment of Educational Progress (NAEP) for reading, published in every major…

  7. The Big Fish

    ERIC Educational Resources Information Center

    DeLisle, Rebecca; Hargis, Jace

    2005-01-01

    The Killer Whale, Shamu jumps through hoops and splashes tourists in hopes for the big fish, not because of passion, desire or simply the enjoyment of doing so. What would happen if those fish were obsolete? Would this killer whale be able to find the passion to continue to entertain people? Or would Shamu find other exciting activities to do…

  8. Big Data and Chemical Education

    ERIC Educational Resources Information Center

    Pence, Harry E.; Williams, Antony J.

    2016-01-01

    The amount of computerized information that organizations collect and process is growing so large that the term Big Data is commonly being used to describe the situation. Accordingly, Big Data is defined by a combination of the Volume, Variety, Velocity, and Veracity of the data being processed. Big Data tools are already having an impact in…

  9. Business and Science - Big Data, Big Picture

    NASA Astrophysics Data System (ADS)

    Rosati, A.

    2013-12-01

    Data Science is more than the creation, manipulation, and transformation of data. It is more than Big Data. The business world seems to have a hold on the term 'data science' and, for now, they define what it means. But business is very different than science. In this talk, I address how large datasets, Big Data, and data science are conceptually different in business and science worlds. I focus on the types of questions each realm asks, the data needed, and the consequences of findings. Gone are the days of datasets being created or collected to serve only one purpose or project. The trick with data reuse is to become familiar enough with a dataset to be able to combine it with other data and extract accurate results. As a Data Curator for the Advanced Cooperative Arctic Data and Information Service (ACADIS), my specialty is communication. Our team enables Arctic sciences by ensuring datasets are well documented and can be understood by reusers. Previously, I served as a data community liaison for the North American Regional Climate Change Assessment Program (NARCCAP). Again, my specialty was communicating complex instructions and ideas to a broad audience of data users. Before entering the science world, I was an entrepreneur. I have a bachelor's degree in economics and a master's degree in environmental social science. I am currently pursuing a Ph.D. in Geography. Because my background has embraced both the business and science worlds, I would like to share my perspectives on data, data reuse, data documentation, and the presentation or communication of findings. My experiences show that each can inform and support the other.

  10. The geography and ecology of plant speciation: range overlap and niche divergence in sister species.

    PubMed

    Anacker, Brian L; Strauss, Sharon Y

    2014-03-07

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under 'budding' speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister-non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities.

  11. The KBG syndrome: follow-up data on three affected brothers.

    PubMed

    Soekarman, D; Volcke, P; Fryns, J P

    1994-10-01

    In this report we present follow-up data on a family in which several members were found to have short stature, craniofacial anomalies and dento-skeletal abnormalities (KBG-syndrome). As adults, the three affected brothers of the original report are moderately to severely mentally retarded. Their phenotype with a distinct craniofacial appearance did not change much from that seen during childhood and adolescence. Adult height is far below the third centile, with arm spans exceeding stature by at least 9 cm.

  12. Joubert syndrome with bilateral polymicrogyria: clinical and neuropathological findings in two brothers.

    PubMed

    Giordano, L; Vignoli, A; Pinelli, L; Brancati, F; Accorsi, P; Faravelli, F; Gasparotti, R; Granata, T; Giaccone, G; Inverardi, F; Frassoni, C; Dallapiccola, B; Valente, E M; Spreafico, R

    2009-07-01

    Joubert syndrome (JS) is characterized by hypotonia, ataxia, developmental delay, and a typical neuroimaging finding, the so-called "molar tooth sign" (MTS). The association of MTS and polymicrogyria (PMG) has been reported as a distinct JS-related disorder (JSRD). So far, five patients have been reported with this phenotype, only two of them being siblings. We report on one additional family, describing a living child with JS and PMG, and the corresponding neuropathological picture in the aborted brother. No mutations were detected in the AHI1 gene, the only so far associated with the JS + PMG phenotype. Moreover, linkage analysis allowed excluding all known gene loci, suggesting further genetic heterogeneity.

  13. Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers.

    PubMed

    Libernini, Laura; Lupis, Chiara; Mastrangelo, Mario; Carrozzo, Rosalba; Santorelli, Filippo Maria; Inghilleri, Maurizio; Leuzzi, Vincenzo

    2012-08-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE, MIM 603041) is an autosomal recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP). Clinical features of MNGIE include gastrointestinal dysmotility, cachexia, ptosis or ophthalmoparesis, peripheral neuropathy, diffuse leukoencephalopathy, and signs of mitochondrial dysfunction in tissues. We report the clinical and molecular findings in two brothers in whom novel TYMP gene mutations (c.215-13_215delinsGCGTGA; c.1159 + 2T > A) were associated with different clinical presentations and outcomes.

  14. Klinefelter's syndrome in nontwin brothers and maternal XX/XXX mosaicism.

    PubMed

    Lodi, A; Monti, D; Gaspari, G; Ravaglia, G; Guadagni, C; Businello, M; Lamedica, R; Lenzi, S

    1979-01-01

    A case of two nontwin brothers, 19 and 17 years old, who had both Klinefelter's syndrome with a chromosomal mosaicism 46 XY/47 XXY, is reported here. The analysis of their mother's karyotype revealed a 46 XX/47 XXX mosaicism. It is hypothesized that the presence of an extra X chromosome in all three subjects could depend on the transmission of two X chromosomes from the mother to the sons or, less likely, on an increased liability to nondisjunction of the X chromosomes during one of the early mitotic divisions in the zygotes.

  15. Sisters Helping Sisters.

    ERIC Educational Resources Information Center

    Wright, Madeleine E.

    This book is a comprehensive guide to the philosophy, organization, and management of a mentoring program for African American girls. It is based on a program sponsored by the Wheeler Avenue Baptist Church in Houston (Texas). This program matches between 25 and 50 young women with Christian women mentors. The program emphasizes Christian values,…

  16. How Big Are "Martin's Big Words"? Thinking Big about the Future.

    ERIC Educational Resources Information Center

    Gardner, Traci

    "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." tells of King's childhood determination to use "big words" through biographical information and quotations. In this lesson, students in grades 3 to 5 explore information on Dr. King to think about his "big" words, then they write about their own…

  17. Chromosome orientation fluorescence in situ hybridization (CO-FISH) to study sister chromatid segregation in vivo

    PubMed Central

    Falconer, Ester; Chavez, Elizabeth; Henderson, Alexander; Lansdorp, Peter M.

    2013-01-01

    Previously, assays for sister chromatid segregation patterns relied on incorporation of BrdU and indirect methods to infer segregation patterns after two cell divisions. Here we describe a method to differentially label sister chromatids of murine cells and directly assay sister chromatid segregation patterns following one cell division in vitro and in vivo by adaptation of the well-established CO-FISH (chromosome orientation fluorescent in situ hybridization) technique. 5-bromo-2′-deoxyuridine (BrdU) is incorporated into newly-formed DNA strands, followed by photolysis and exonuclease digestion to create single-stranded sister chromatids containing parental template DNA only. Such single-stranded sister chromatids are differentially labeled using unidirectional probes to major satellite sequences coupled to fluorescent markers. Differentially-labeled sister chromatids in post-mitotic cells are visualized using fluorescence microscopy and sister chromatid segregation patterns can be directly assayed after one cell division. This procedure requires four days for in vivo mouse tissues, and two days for in vitro cultured cells. PMID:20595964

  18. Chloroplast phylogenomics indicates that Ginkgo biloba is sister to cycads.

    PubMed

    Wu, Chung-Shien; Chaw, Shu-Miaw; Huang, Ya-Yi

    2013-01-01

    Molecular phylogenetic studies have not yet reached a consensus on the placement of Ginkgoales, which is represented by the only living species, Ginkgo biloba (common name: ginkgo). At least six discrepant placements of ginkgo have been proposed. This study aimed to use the chloroplast phylogenomic approach to examine possible factors that lead to such disagreeing placements. We found the sequence types used in the analyses as the most critical factor in the conflicting placements of ginkgo. In addition, the placement of ginkgo varied in the trees inferred from nucleotide (NU) sequences, which notably depended on breadth of taxon sampling, tree-building methods, codon positions, positions of Gnetopsida (common name: gnetophytes), and including or excluding gnetophytes in data sets. In contrast, the trees inferred from amino acid (AA) sequences congruently supported the monophyly of a ginkgo and Cycadales (common name: cycads) clade, regardless of which factors were examined. Our site-stripping analysis further revealed that the high substitution saturation of NU sequences mainly derived from the third codon positions and contributed to the variable placements of ginkgo. In summary, the factors we surveyed did not affect results inferred from analyses of AA sequences. Congruent topologies in our AA trees give more confidence in supporting the ginkgo-cycad sister-group hypothesis.

  19. Newly discovered sister lineage sheds light on early ant evolution

    PubMed Central

    Rabeling, Christian; Brown, Jeremy M.; Verhaagh, Manfred

    2008-01-01

    Ants are the world's most conspicuous and important eusocial insects and their diversity, abundance, and extreme behavioral specializations make them a model system for several disciplines within the biological sciences. Here, we report the discovery of a new ant that appears to represent the sister lineage to all extant ants (Hymenoptera: Formicidae). The phylogenetic position of this cryptic predator from the soils of the Amazon rainforest was inferred from several nuclear genes, sequenced from a single leg. Martialis heureka (gen. et sp. nov.) also constitutes the sole representative of a new, morphologically distinct subfamily of ants, the Martialinae (subfam. nov.). Our analyses have reduced the likelihood of long-branch attraction artifacts that have troubled previous phylogenetic studies of early-diverging ants and therefore solidify the emerging view that the most basal extant ant lineages are cryptic, hypogaeic foragers. On the basis of morphological and phylogenetic evidence we suggest that these specialized subterranean predators are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant diversification and have persisted in ecologically stable environments like tropical soils over great spans of time. PMID:18794530

  20. Mars' atmosphere: The sister planet, our statistical twin

    NASA Astrophysics Data System (ADS)

    Chen, Wilbur; Lovejoy, Shaun; Muller, Jan-Peter

    2016-10-01

    Satellite-based Martian reanalyses have allowed unprecedented comparisons between our atmosphere and that of our sister planet, underlining various similarities and differences in their respective dynamics. Yet by focusing on large scale structures and deterministic mechanisms they have improved our understanding of the dynamics only over fairly narrow ranges of (near) planetary scales. However, the Reynolds numbers of the flows on both planets are larger than 1011 and dissipation only occurs at centimetric (Mars) or millimetric scales (Earth) so that over most of their scale ranges, the dynamics are fully turbulent. In this paper, we therefore examine the high-level, statistical, turbulent laws for the temperature, horizontal wind, and surface pressure, finding that Earth and Mars have virtually identical statistical exponents so that their statistics are very similar over wide ranges. Therefore, it would seem that with the exception of certain aspects of the largest scales (such as the role of dust in atmospheric heating on Mars, or of water in its various phases on Earth), that the nonlinear dynamics are very similar. We argue that this is a prediction of the classical laws of turbulence when extended to planetary scales and that it supports our use of turbulent laws on both planetary atmospheres.

  1. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.

    PubMed

    Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

    2010-03-04

    The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier.

  2. Two sisters in the same dress: Heliconius cryptic species

    PubMed Central

    2008-01-01

    Background Sister species divergence and reproductive isolation commonly results from ecological adaptation. In mimetic Heliconius butterflies, shifts in colour pattern contribute to pre- and post-mating reproductive isolation and are commonly correlated with speciation. Closely related mimetic species are therefore not expected, as they should lack several important sources of reproductive isolation. Results Here we present phenotypic, behavioral and genetic evidence for the coexistence of two sympatric 'cryptic' species near Florencia in the eastern Andes of Colombia that share the same orange rayed colour pattern. These represent H. melpomene malleti and a novel taxon in the H. cydno group, here designated as novel race of Heliconius timareta, Heliconius timareta florencia. No-choice mating experiments show that these sympatric forms have strong assortative mating (≈96%) despite great similarity in colour pattern, implying enhanced divergence in pheromonal signals. Conclusion We hypothesize that these species might have resulted from recent convergence in colour pattern, perhaps facilitated by hybrid introgression of wing pattern genes. PMID:19040737

  3. Sororin actively maintains sister chromatid cohesion.

    PubMed

    Ladurner, Rene; Kreidl, Emanuel; Ivanov, Miroslav P; Ekker, Heinz; Idarraga-Amado, Maria Helena; Busslinger, Georg A; Wutz, Gordana; Cisneros, David A; Peters, Jan-Michael

    2016-03-15

    Cohesion between sister chromatids is established during DNA replication but needs to be maintained to enable proper chromosome-spindle attachments in mitosis or meiosis. Cohesion is mediated by cohesin, but also depends on cohesin acetylation and sororin. Sororin contributes to cohesion by stabilizing cohesin on DNA. Sororin achieves this by inhibiting WAPL, which otherwise releases cohesin from DNA and destroys cohesion. Here we describe mouse models which enable the controlled depletion of sororin by gene deletion or auxin-induced degradation. We show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation. We further show that the acetyltransferases ESCO1 and ESCO2 are essential for stabilizing cohesin on chromatin, that their only function in this process is to acetylate cohesin's SMC3 subunit, and that DNA replication is also required for stable cohesin-chromatin interactions. Unexpectedly, we find that sororin interacts dynamically with the cohesin complexes it stabilizes. This implies that sororin recruitment to cohesin does not depend on the DNA replication machinery or process itself, but on a property that cohesin acquires during cohesion establishment.

  4. Familial orthostatic tremor and essential tremor in two young brothers: A rare entity.

    PubMed

    Bhattacharyya, Kalyan B; Das, D

    2013-04-01

    Orthostatic tremor (OT), is usually a disease of old age and is characterized by quivering movements of the legs during quiet standing or in the state of isometric contraction in the lower limbs. This is relieved on walking or on lying down. It is diagnosed by surface electromyography, particularly over the quadriceps femoris muscles which shows a distinctive frequency of 13 to 18 Hz on standing. Some investigators consider it as a variant of essential tremor (ET) and the two conditions often co-exist. The disease is usually non-familial. Two brothers presented with tremor in the lower limbs on standing and on the outstretched hands without any family history. Subsequently, they were proved to be suffering from OT and ET by clinical examination and surface EMG. Simultaneous occurrence of OT and ET in two young brothers without any family history in the previous generation has not been described before and they also appeared at a much earlier age than what is described in the literature.

  5. DARPA's Big Mechanism program

    NASA Astrophysics Data System (ADS)

    Cohen, Paul R.

    2015-07-01

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

  6. A holographic big bang?

    NASA Astrophysics Data System (ADS)

    Afshordi, N.; Mann, R. B.; Pourhasan, R.

    2015-11-01

    We present a cosmological model in which the Universe emerges out of the collapse of a five-dimensional (5D) star as a spherical three-brane. The initial singularity of the big bang becomes hidden behind a causal horizon. Near scale-invariant primordial curvature perturbations can be induced on the brane via a thermal atmosphere that is in equilibrium with the brane, circumventing the need for a separate inflationary process and providing an important test of the model.

  7. The Next Big Idea

    PubMed Central

    2013-01-01

    Abstract George S. Eisenbarth will remain in our memories as a brilliant scientist and great collaborator. His quest to discover the cause and prevention of type 1 (autoimmune) diabetes started from building predictive models based on immunogenetic markers. Despite his tremendous contributions to our understanding of the natural history of pre-type 1 diabetes and potential mechanisms, George left us with several big questions to answer before his quest is completed. PMID:23786296

  8. DARPA's Big Mechanism program.

    PubMed

    Cohen, Paul R

    2015-07-16

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

  9. Big3. Editorial

    PubMed Central

    Lehmann, Christoph U.; Séroussi, Brigitte; Jaulent, Marie-Christine

    2014-01-01

    Summary Objectives To provide an editorial introduction into the 2014 IMIA Yearbook of Medical Informatics with an overview of the content, the new publishing scheme, and upcoming 25th anniversary. Methods A brief overview of the 2014 special topic, Big Data - Smart Health Strategies, and an outline of the novel publishing model is provided in conjunction with a call for proposals to celebrate the 25th anniversary of the Yearbook. Results ‘Big Data’ has become the latest buzzword in informatics and promise new approaches and interventions that can improve health, well-being, and quality of life. This edition of the Yearbook acknowledges the fact that we just started to explore the opportunities that ‘Big Data’ will bring. However, it will become apparent to the reader that its pervasive nature has invaded all aspects of biomedical informatics – some to a higher degree than others. It was our goal to provide a comprehensive view at the state of ‘Big Data’ today, explore its strengths and weaknesses, as well as its risks, discuss emerging trends, tools, and applications, and stimulate the development of the field through the aggregation of excellent survey papers and working group contributions to the topic. Conclusions For the first time in history will the IMIA Yearbook be published in an open access online format allowing a broader readership especially in resource poor countries. For the first time, thanks to the online format, will the IMIA Yearbook be published twice in the year, with two different tracks of papers. We anticipate that the important role of the IMIA yearbook will further increase with these changes just in time for its 25th anniversary in 2016. PMID:24853037

  10. The geography and ecology of plant speciation: range overlap and niche divergence in sister species

    PubMed Central

    Anacker, Brian L.; Strauss, Sharon Y.

    2014-01-01

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister–non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities

  11. Big Sky Carbon Atlas

    DOE Data Explorer

    The Big Sky Carbon Atlas is an online geoportal designed for you to discover, interpret, and access geospatial data and maps relevant to decision support and education on carbon sequestration in the Big Sky Region. In serving as the public face of the Partnership's spatial Data Libraries, the Atlas provides a gateway to geographic information characterizing CO2 sources, potential geologic sinks, terrestrial carbon fluxes, civil and energy infrastructure, energy use, and related themes. In addition to directly serving the BSCSP and its stakeholders, the Atlas feeds regional data to the NatCarb Portal, contributing to a national perspective on carbon sequestration. Established components of the Atlas include a gallery of thematic maps and an interactive map that allows you to: • Navigate and explore regional characterization data through a user-friendly interface • Print your map views or publish them as PDFs • Identify technical references relevant to specific areas of interest • Calculate straight-line or pipeline-constrained distances from point sources of CO2 to potential geologic sink features • Download regional data layers (feature under development) (Acknowledgment to the Big Sky Carbon Sequestration Partnership (BSCSP); see home page at http://www.bigskyco2.org/)

  12. Special Review of Smart Start Expenditures by Save Our Brothers, Inc. (Pittsboro, North Carolina) and Liberty Chapel United Church of Christ (Moncure, North Carolina).

    ERIC Educational Resources Information Center

    North Carolina Office of the State Auditor, Raleigh.

    This report of the Office of the State Auditor in North Carolina details audit findings regarding allegations of misuse of Smart Start funds by Save Our Brothers, Inc. and the Liberty Chapel United Church of Christ. Save Our Brothers, Inc., a nonprofit agency, received two contracts totaling $46,327 from the Chatham County Partnership for Children…

  13. Are stepfathers' education levels associated with the intelligence of their stepsons? A register-based study of Norwegian half-brothers.

    PubMed

    Eriksen, Willy; Sundet, Jon M; Tambs, Kristian

    2013-05-01

    We examined the relationship between the parents' education levels and the adult intelligence of their children in a population-based, nationwide sample of Norwegian half-brothers with different fathers (2,016 pairs of half-brothers). In a family where the mother has two children with different men, the firstborn child usually lives with the younger child's father during a period of their childhood. This makes it possible to study the non-genetic effects of paternal education on children's development. Results showed that the education level of the younger half-brother's father was positively associated with the intelligence score of the older half-brother. The education level of the older half-brother's father was not associated with the intelligence score of the younger half-brother. Firstborn men whose half-brothers' fathers had high levels of education had intelligence scores that were 33% (95% confidence interval: 18-47%) of a standard deviation higher than those of firstborn men whose half-brothers' fathers had low levels of education, after adjustment for the biological fathers' education levels, mothers' education levels, and other background factors. These findings are compatible with the hypothesis that a child's family environment exerts an effect on the cognitive abilities of the child that lasts into adulthood.

  14. Disaggregating asthma: Big investigation versus big data.

    PubMed

    Belgrave, Danielle; Henderson, John; Simpson, Angela; Buchan, Iain; Bishop, Christopher; Custovic, Adnan

    2017-02-01

    We are facing a major challenge in bridging the gap between identifying subtypes of asthma to understand causal mechanisms and translating this knowledge into personalized prevention and management strategies. In recent years, "big data" has been sold as a panacea for generating hypotheses and driving new frontiers of health care; the idea that the data must and will speak for themselves is fast becoming a new dogma. One of the dangers of ready accessibility of health care data and computational tools for data analysis is that the process of data mining can become uncoupled from the scientific process of clinical interpretation, understanding the provenance of the data, and external validation. Although advances in computational methods can be valuable for using unexpected structure in data to generate hypotheses, there remains a need for testing hypotheses and interpreting results with scientific rigor. We argue for combining data- and hypothesis-driven methods in a careful synergy, and the importance of carefully characterized birth and patient cohorts with genetic, phenotypic, biological, and molecular data in this process cannot be overemphasized. The main challenge on the road ahead is to harness bigger health care data in ways that produce meaningful clinical interpretation and to translate this into better diagnoses and properly personalized prevention and treatment plans. There is a pressing need for cross-disciplinary research with an integrative approach to data science, whereby basic scientists, clinicians, data analysts, and epidemiologists work together to understand the heterogeneity of asthma.

  15. Wild female baboons bias their social behaviour towards paternal half-sisters.

    PubMed Central

    Smith, Kerri; Alberts, Susan C; Altmann, Jeanne

    2003-01-01

    Adult female cercopithecines have long been known to bias their social behaviour towards close maternal kin. However, much less is understood about the behaviour of paternal kin, especially in wild populations. Here, we show that wild adult female baboons bias their affiliative behaviour towards their adult paternal half-sisters in the same manner and to the same extent that they bias their behaviour towards adult maternal half-sisters. Females appear to rely heavily on social familiarity as a means of biasing their behaviour towards paternal half-sisters, but may use phenotype matching as well. PMID:12641905

  16. Sister chromatid exchange data and Gram-Charlier series.

    PubMed

    Bowman, K O; Eddings, W; Kastenbaum, M A; Shenton, L R

    1998-07-17

    Bowman et al. [K.O. Bowman, M.A. Kastenbaum, L.R. Shenton, Fitting multi-parameter distributions to SCE data, Mutat. Res., 358 (1996) 15-24.] showed how discrete Pearson and discrete Johnson translation-system distributions may be fitted to sister chromatid exchange (SCE) data presented by Bender et al. [M.A. Bender, R.J. Pearston, R.C. Leonard, B.E. Pyatt, P.C. Gooch, On the distribution of spontaneous SCE in human peripheral blood lymphocytes, Mutat. Res., 281 (1992) 227-232.]. When their performances were measured by the chi-squared test of goodness of fit, these distributions proved to be only moderately better alternatives to the poorly fitting Poisson, binomial, and negative binomial distributions. In this paper, we extend our search for better characterizations of the SCE data by calling upon the Gram-Charlier type B approximation of the negative binomial distribution. We introduce an innovative extension of methods described in a little-known paper by Aitken and Gonin [A.C. Aitken, H.T. Gonin, On fourfold sampling with and without replacement, Proc. R. Soc. Edinburgh, 55 (1934) 114-125.], and show how this leads to fits of the SCE data that, in general, are within acceptable levels of probability. Moreover, we show how a theorem by Cramér [H. Cramér, Mathematical Methods of Statistics, Princeton Univ. Press, 1946.], relating to the scale factor m2/m'1 and its asymptotic distribution, may be used to discriminate between smokers and nonsmokers of the same gender.

  17. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges

    PubMed Central

    Maeda, Junko; Yurkon, Charles R.; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A.; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A.

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140

  18. On Sister, Where Art Thou? The Galilean Satellites After Galileo

    NASA Astrophysics Data System (ADS)

    McKinnon, W. B.

    2006-12-01

    A rich picture has emerged of the four Galileans in the last decade, but for each moon fundamental questions naturally remain unanswered. I will attempt to review a selection of these whose broader application to planetary and satellite science may prove important. Io's volcanic hyperactivity is well known, and offers clues to Io's tidally heated interior state, but the same effusions obscure much of what happens in the interior. The magmas are hot, but how hot? What is the spatial pattern of tidal heating and how is magma transported? Are models based on upwelling of the Earth's upper mantle sufficient, or must more exotic models, such as porous flow through a non-convecting solid matrix, be invoked? What about the canonical (at least at one time) magma ocean? Are Io's spectacular mountains mere "window dressing" or vital clues to otherwise perplexing interior processes? Moving to the exterior moon, Callisto, the central scientific question for this body is how it acquired its ocean yet managed not to be deeply melted (differentiated)? Ganymede (an honorary sister) is ostensibly deeply differentiated, but the existence (if not persistence) of a strong magnetic dynamo within its iron core is a profound puzzle. At the surface, the relative roles of ice-water volcanism and tectonic resurfacing in creating the grooved and "smooth" terrains that cover 2/3 of the solar system's largest satellite remain debated. The stakes for understanding ice resurfacing elsewhere (Europa, Enceladus) are great. And it is Europa that commands our greatest attention. A decade of research has reached a level of maturity: while researchers may disagree on shell thickness, the consensus is that the ocean exists. With a massive body of liquid water, multiple energy sources proposed, and different paths to provide C and other biogenic elements, the central question is Europa's potential for life. There is no greater question.

  19. Endovascular Repair of Internal Mammary Artery Aneurysms in Two Sisters with SMAD3 Mutation.

    PubMed

    Nevidomskyte, Daiva; Shalhub, Sherene; Aldea, Gabriel S; Byers, Peter H; Schwarze, Ulrike; Murray, Mitzi L; Starnes, Benjamin

    2017-03-07

    True aneurysms of the internal mammary artery are rare and have been described in association with vasculitis or connective tissue disorders. Herein we describe two cases of familial internal mammary artery aneurysms in two sisters with SMAD3 mutation. The older sister presented at the age of 54 with an incidental diagnosis of a multilobed right internal mammary artery aneurysm (IMA) and the younger sister presented several years earlier with a ruptured left IMA aneurysm at the age of 49. Both sisters had Debakey type I aortic dissections prior to the IMA aneurysm presentation. To our knowledge this is the first time IMA aneurysms has been described in siblings with SMAD3 mutation. In our experience endovascular repair is a feasible and safe treatment option. An assessment of the entire arterial tree is recommended in patients diagnosed with SMAD3 mutations.

  20. Psychopathology, childhood trauma, and personality traits in patients with borderline personality disorder and their sisters.

    PubMed

    Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer

    2011-08-01

    The aim of this study was to document and compare adverse childhood experiences, and personality profiles in women with borderline personality disorder (BPD) and their sisters, and to determine how these factors impact current psychopathology. Fifty-six patients with BPD and their sisters were compared on measures assessing psychopathology, personality traits, and childhood adversities. Most sisters showed little evidence of psychopathology. Both groups reported dysfunctional parent-child relationships and a high prevalence of childhood trauma. Subjects with BPD reported experiencing more emotional abuse and intrafamilial sexual abuse, but more similarities than differences between probands and sisters were found. In multilevel analyses, personality traits of affective instability and impulsivity predicted DIB-R scores and SCL-90-R scores, above and beyond trauma. There were few relationships between childhood adversities and other measures of psychopathology. Sensitivity to adverse experiences, as reflected in the development of psychopathology, appears to be influenced by personality trait profiles.

  1. Sister Circles as a Culturally Relevant Intervention for Anxious African American Women

    PubMed Central

    Neal-Barnett, Angela; Stadulis, Robert; Murray, Marsheena; Payne, Margaret Ralston; Thomas, Anisha; Salley, Bernadette B.

    2011-01-01

    Research on anxiety treatment with African American women reveals a need to develop interventions that address factors relevant to their lives. Such factors include feelings of isolation, multiple roles undertaken by Black women, and faith. A recurrent theme across treatment studies is the importance of having support from other Black women. Sister circles are support groups that build upon existing friendships, fictive kin networks, and the sense of community found among African Americans females. Sister circles appear to offer many of the components Black women desire in an anxiety intervention. In this article, we explore sister circles as an intervention for anxious African American women. Culturally-infused aspects from our sister circle work with middle-class African American women are presented. Further research is needed. PMID:22081747

  2. First Submersible Dives on Brothers Volcano, Kermadec Arc, Offshore New Zealand

    NASA Astrophysics Data System (ADS)

    de Ronde, C. E.; Massoth, G. J.; Ishibashi, J.; Embley, R. W.; Lupton, J. E.; Butterfield, D. A.; Yamanaka, T.; Evans, L. J.; Takai, K.

    2005-12-01

    Previous NZAPLUME and other cruises between 1999 and 2004 established that at least three major hydrothermal sites occur at Brothers; the NW caldera and cone sites are actively venting while the SE caldera site is extinct. In October 2004, the submersible Shinkai 6500 did 4 dives on Brothers as part of the SWEEP Vents expedition, the first dives anywhere along the 2,500 Kermadec-Tonga arc. Between April and May, 2005, an additional 5 dives were made at Brothers using the HURL submersible Pisces V as part of a New Zealand and NOAA co-sponsored expedition. In total, 6 dives have been done at the NW caldera site and 3 at the cone site. The NW caldera site is host to a significant sulfide deposit. It mainly crops out along a zone of discrete, narrow, fault bounded ledges between ~1600 and 1680 m, over strike lengths up to ~500 m. Locally, bands of active and extinct black smoker chimneys up to 7 m tall occur in this zone and strike orthogonal to the caldera walls, indicative of cross structures. Abundant sulfide talus and subcropping massive sulfides also occur at this site. The submersible dives recorded extensive alteration of the caldera walls and sampled individual chimneys, Fe-oxide crusts, and altered rocks. The cone site is hosted by ash and talus and is dominated near its summit by extensive deposition of elemental S and Fe-oxide crusts. No sulfides have been recovered from this site. Preliminary vent fluids results are from samples collected by the Shinkai 6500. They show two very different hydrothermal fluids. Those from the NW caldera site have temperatures up to 302°C, pH down to 2.8, low Mg and SO4 values, Cl between 510 and 760 mM, elevated Si and increasing Fe and Mn values with increasing Cl concentrations, consistent with a Cl-enriched endmember. By contrast, vent fluids from the cone site are gas-rich (up to 220 mM total gas), have temperatures <70°C, pH down to 1.9, Mg values near seawater concentrations and higher, Cl <550 mM and low levels of Si

  3. A molecular test of alternative hypotheses of tetraodontiform (Acanthomorpha: Tetraodontiformes) sister group relationships using data from the RAG1 gene.

    PubMed

    Holcroft, Nancy I

    2004-09-01

    Two primary competing hypotheses regarding the identity of the sister group of the order Tetraodontiformes exist. The first hypothesis holds that some or all acanthuroid fishes represent the sister of Tetraodontiformes. The second, proposed in 1984 by Rosen, holds that the order Zeiformes is sister to Tetraodontiformes and that the family Caproidae is sister to this Zeiformes + Tetraodontiformes clade. These two hypotheses were tested using data from the single-copy nuclear gene RAG1. Representatives of most major orders of acanthomorph fishes were included to provide an appropriate context in which to place Tetraodontiformes and its hypothesized sister groups. The results of an unweighted parsimony analysis indicate that Zeiformes is not the sister group of Tetraodontiformes. In addition, Caproidae appears unrelated to Zeiformes. A monophyletic Tetraodontiformes was recovered as the sister group of the clade Ephippidae + Drepanidae and was more distantly related to the included zeiform and caproid representatives.

  4. How Big is Earth?

    NASA Astrophysics Data System (ADS)

    Thurber, Bonnie B.

    2015-08-01

    How Big is Earth celebrates the Year of Light. Using only the sunlight striking the Earth and a wooden dowel, students meet each other and then measure the circumference of the earth. Eratosthenes did it over 2,000 years ago. In Cosmos, Carl Sagan shared the process by which Eratosthenes measured the angle of the shadow cast at local noon when sunlight strikes a stick positioned perpendicular to the ground. By comparing his measurement to another made a distance away, Eratosthenes was able to calculate the circumference of the earth. How Big is Earth provides an online learning environment where students do science the same way Eratosthenes did. A notable project in which this was done was The Eratosthenes Project, conducted in 2005 as part of the World Year of Physics; in fact, we will be drawing on the teacher's guide developed by that project.How Big Is Earth? expands on the Eratosthenes project by providing an online learning environment provided by the iCollaboratory, www.icollaboratory.org, where teachers and students from Sweden, China, Nepal, Russia, Morocco, and the United States collaborate, share data, and reflect on their learning of science and astronomy. They are sharing their information and discussing their ideas/brainstorming the solutions in a discussion forum. There is an ongoing database of student measurements and another database to collect data on both teacher and student learning from surveys, discussions, and self-reflection done online.We will share our research about the kinds of learning that takes place only in global collaborations.The entrance address for the iCollaboratory is http://www.icollaboratory.org.

  5. A Critical Study of the Effectiveness of the Seven Christian Brothers' College Art Departments in the United States.

    ERIC Educational Resources Information Center

    Brom, Giles

    The effectiveness of the seven Christian Brothers' college art departments in the United States was studied. Attention was directed to: programs being offered in the arts, the effectiveness of these programs, approaches to upgrade weak programs, trends in the number of art majors during 1978-1983, and trends in the number of students registered in…

  6. My Brother's Keeper: How Commerce Has Created Pathways to Success in the Workforce for Our Nation's Youth

    ERIC Educational Resources Information Center

    US Department of Commerce, 2017

    2017-01-01

    In 2014, President Obama launched the My Brother's Keeper (MBK) initiative to address persistent opportunity gaps faced by boys and young men of color and to ensure that all young people can reach their full potential. Through this initiative, the Administration has partnered with cities, towns, businesses, and foundations to connect young people…

  7. Russia: despite legislative and procedural barriers, HIV-positive woman fights for custody of ten-year-old brother.

    PubMed

    Utyasheva, Leah

    2009-12-01

    Svetlana Izambaeva, a well-known HIV-activist and educator in Russia, is seeking to obtain custody of her ten-year-old brother, Sasha. After their mother died, regional official refused Izambaeva custody because of her HIV-positive status. Consequently, the local child custody agency (organ opeki) decided to give Sasha to a foster family.

  8. The Critical Importance of Technology Integration in the Business School Curriculum: How Christian Brothers University is Meeting This Challenge.

    ERIC Educational Resources Information Center

    Wade, James S.

    This paper details the importance of a successful implementation of technology into the business school curriculum and the Christian Brothers University's (CBU) (Tennessee) approach to such integration. The technology awareness of students and technology planning with regard to facilities, and curriculum are outlined. An overview of the following…

  9. The Prophet of Revealed Knowledge: Richard Brother, the Prince of the Hebrews and Nephew of the Almighty.

    ERIC Educational Resources Information Center

    Schamber, Jon F.; Stroud, Scott R.

    Seeking the answers as to what makes one speaker more charismatic than another and why some speeches are merely effective while others move audiences to a transcendent state is a difficult task. This paper follows up on this challenge and seeks to provide some answers as to how the prophetic works of Richard Brothers moved his followers to a…

  10. Growth and Education: A Strategic Report to the Rockefeller Brothers Fund on the Implications of Growth Policy for Postsecondary Education

    ERIC Educational Resources Information Center

    Perelman, Lewis J.; Berquist, William, H.

    This document attempts to identify for the Rockefeller Brothers Fund how it may best invest its resources in postsecondary education to facilitate transformation to an equilibrium state. As the work of the project developed, it was found that the issue of "limits to growth and higher education" had two facets: (1) what role can the postsecondary…

  11. Ecological divergence and speciation between lemur (Eulemur) sister species in Madagascar.

    PubMed

    Blair, M E; Sterling, E J; Dusch, M; Raxworthy, C J; Pearson, R G

    2013-08-01

    Understanding ecological niche evolution over evolutionary timescales is crucial to elucidating the biogeographic history of organisms. Here, we used, for the first time, climate-based ecological niche models (ENMs) to test hypotheses about ecological divergence and speciation processes between sister species pairs of lemurs (genus Eulemur) in Madagascar. We produced ENMs for eight species, all of which had significant validation support. Among the four sister species pairs, we found nonequivalent niches between sisters, varying degrees of niche overlap in ecological and geographic space, and support for multiple divergence processes. Specifically, three sister-pair comparisons supported the null model that niches are no more divergent than the available background region. These findings are consistent with an allopatric speciation model, and for two sister pairs (E. collaris-E. cinereiceps and E. rufus-E. rufifrons), a riverine barrier has been previously proposed for driving allopatric speciation. However, for the fourth sister pair E. flavifrons-E. macaco, we found support for significant niche divergence, and consistent with their parapatric distribution on an ecotone and the lack of obvious geographic barriers, these findings most strongly support a parapatric model of speciation. These analyses thus suggest that various speciation processes have led to diversification among closely related Eulemur species.

  12. Genomic data do not support comb jellies as the sister group to all other animals.

    PubMed

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-12-15

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the "Ctenophora-sister" hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data.

  13. Exon 44 nonsense mutation in two-Duchenne muscular dystrophy brothers detected by heteroduplex analysis.

    PubMed

    Prior, T W; Papp, A C; Snyder, P J; Burghes, A H; Sedra, M S; Western, L M; Bartolo, C; Mendell, J R

    1993-01-01

    Utilizing a heteroduplex method, we screened the dystrophin exon 43-45 region for point mutations, including small deletions and insertions. The method depends upon the formation of a heteroduplex between wild-type and mutant DNA PCR products. DNA specimens from one hundred and four DMD patients without detected deletions or duplications were multiplexed amplified for exons 43, 44, and 45. The PCR products were mixed with the PCR products from nonaffected controls, electrophoresed, and examined for the presence of altered mobility heteroduplex bands. An exon 44 nonsense mutation in two DMD brothers and a common intron 44 polymorphism were identified using this approach. Although the exon 44-45 region is a hotspot for deletion breakpoints, it does not appear to be prone to point mutations. The technique is extremely useful for screening several exons simultaneously and it allowed us to screen a large number of patients.

  14. [The brothers of Jumiege--the peripheral nervous system in early French mythology].

    PubMed

    Brean, Are

    2002-03-20

    This article reviews the process of discovery of the nervous system from Pythagoras (570-500 BC) to Galen (130-201 AD). After Galen, no anatomical studies were performed before the renaissance. According to a legend, probably produced for political reasons, two brothers, sons of the French king Clovis II, revolted against their father and were sentenced to loose their physical powers by having the nerves of their arms and legs cut. They were then set adrift on the river Seine, stranding at the Jumiège monastery. The earliest written version of this legend stems from the fourteenth century; it was probably a part of the local French mythology. This indicates that the existence of the peripheral nervous system, and therefore also in part the knowledge contained in the early anatomical works, quite early may have been more or less known outside academic circles.

  15. [1896: How nascent radiotherapy gathered Roentgen, Pasteur and the Lumière brothers].

    PubMed

    Foray, N

    2016-12-01

    On the 4th July, 1896, in his medical office of Les Échelles (Savoie, France), Victor Despeignes performed the very first radiotherapy against cancer, documented by indisputable proofs. However, the intellectual and practical approach that leads to this first radiotherapy may appear unexpected to date. Indeed, it is likely that the treatment that Despeignes applied to his neighbour, who did not suffer from stomach cancer, was born with the indirect support of the Lumière brothers, on the basis of a biological theory (the parasitory theory of cancer) that is irrelevant today, with an experimental protocol based on experiments performed on tuberculosis et in a bifractionated model linked by the constraints of a district medical doctor.

  16. Phelan-McDermid syndrome in two adult brothers: atypical bipolar disorder as its psychopathological phenotype?

    PubMed Central

    Verhoeven, Willem MA; Egger, Jos IM; Willemsen, Marjolein H; de Leijer, Gert JM; Kleefstra, Tjitske

    2012-01-01

    The 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. Its behavioral phenotype comprises sleep disturbances, communication deficits, and motor perseverations. Data on psychological dysfunctions are so far not available. Previous studies have suggested that the loss of one copy of the gene SH3 and multiple ankyrin repeat domains 3 (SHANK3) is related to the neurobehavioral phenotype. Additional genes proximal to SHANK3 are also likely to play a role in the phenotype of patients with larger deletions. The present paper describes two adult brothers with an identical 2.15 Mb 22qter (22q13.32q13.33) deletion, of whom the youngest was referred for evaluation of recurrent mood changes. In both patients, magnetic resonance imaging of the brain showed hypoplasia of the vermis cerebelli. Extensive clinical examinations led to a final diagnosis of atypical bipolar disorder, of which symptoms fully remitted during treatment with a mood stabilizer. In the older brother, a similar psychopathological picture appeared to be present, although less severe and with a later onset. It is concluded that the behavioral phenotype of the 22q13.3 deletion syndrome comprises absent or delayed speech and perseverations with associated autistic-like features, whereas its psychopathological phenotype comprises an atypical bipolar disorder. The latter may have implications for the treatment regime of the syndrome-related behavioral disturbances. PMID:22570549

  17. "Big Events" and Networks.

    PubMed

    Friedman, Samuel; Rossi, Diana; Flom, Peter L

    2006-01-01

    Some, but not all, "big events" such as wars, revolutions, socioeconomic transitions, economic collapses, and ecological disasters in recent years seem to lead to large-scale HIV outbreaks (Friedman et al, in press; Hankins et al 2002). This was true of transitions in the USSR, South Africa and Indonesia, for example, but not those in the Philippines or (so far) in Argentina. It has been hypothesized that whether or not HIV outbreaks occur is shaped in part by the nature and extent of changes in the numbers of voluntary or involuntary risk-takers, which itself may be related to the growth of roles such as sex-sellers or drug sellers; the riskiness of the behaviors engaged in by risk-takers; and changes in sexual and injection networks and other "mixing patterns" variables. Each of these potential causal processes, in turn, is shaped by the nature of pre-existing social networks and the patterns and content of normative regulation and communication that happen within these social networks-and on how these social networks and their characteristics are changed by the "big event" in question. We will present ideas about what research is needed to help understand these events and to help guide both indigenous community-based efforts to prevent HIV outbreaks and also to guide those who organize external intervention efforts and aid.

  18. The Big Read: Case Studies

    ERIC Educational Resources Information Center

    National Endowment for the Arts, 2009

    2009-01-01

    The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

  19. The Rise of Big Data in Neurorehabilitation.

    PubMed

    Faroqi-Shah, Yasmeen

    2016-02-01

    In some fields, Big Data has been instrumental in analyzing, predicting, and influencing human behavior. However, Big Data approaches have so far been less central in speech-language pathology. This article introduces the concept of Big Data and provides examples of Big Data initiatives pertaining to adult neurorehabilitation. It also discusses the potential theoretical and clinical contributions that Big Data can make. The article also recognizes some impediments in building and using Big Data for scientific and clinical inquiry.

  20. A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome Lymphocytes

    PubMed Central

    Chaganti, R. S. K.; Schonberg, S.; German, James

    1974-01-01

    Dividing cells from persons with Bloom's syndrome, an autosomal recessive disorder of growth, exhibit increased numbers of chromatid breaks and rearrangements. A highly characteristic feature of the chromosome instability in this syndrome is the tendency for exchanges to occur between chromatids of homologous chromosomes at homologous sites. In the present experiments, a cytogenetic technique by which the sister chromatids of a metaphase chromosome are stained differentially has been used to demonstrate a striking and possibly specific, but hitherto unrecognized, increase in the frequency with which sister chromatids also exchange segments. The cells were grown in bromodeoxyuridine and stained with 33258 Hoechst and Giemsa. Whereas phytohemagglutinin-stimulated lymphocytes from normal controls had a mean of 6.9 sister chromatid exchanges per metaphase (range 1-14), those from persons with Bloom's syndrome had a mean of 89.0 (range 45-162). Normal frequencies of sister chromatid exchanges were found in cells heterozygous for the Bloom's syndrome gene, and also in cells either homozygous or heterozygous for the genes of the Louis-Bar (ataxia telangiectasia) syndrome and Fanconi's anemia, two other rare disorders characterized by chromosome instability. In a differentially stained chromatid interchange configuration discovered during the study, it was possible to determine the new distribution of both sister and non-sister-but-homologous chromatids that had resulted from numerous exchanges. By following shifts in the pattern of staining from chromatid to chromatid, visual evidence was obtained that the quadriradial configurations long recognized as characteristic of Bloom's syndrome represent exchanges between homologous chromosomes, apparently at homologous points. We postulate that the increase in the frequency of exchanges between nonsister-but-homologous chromatids and those between sister chromatids in Bloom's syndrome represents aspects of one and the same

  1. BIG DATA AND STATISTICS

    PubMed Central

    Rossell, David

    2016-01-01

    Big Data brings unprecedented power to address scientific, economic and societal issues, but also amplifies the possibility of certain pitfalls. These include using purely data-driven approaches that disregard understanding the phenomenon under study, aiming at a dynamically moving target, ignoring critical data collection issues, summarizing or preprocessing the data inadequately and mistaking noise for signal. We review some success stories and illustrate how statistical principles can help obtain more reliable information from data. We also touch upon current challenges that require active methodological research, such as strategies for efficient computation, integration of heterogeneous data, extending the underlying theory to increasingly complex questions and, perhaps most importantly, training a new generation of scientists to develop and deploy these strategies. PMID:27722040

  2. Big cat genomics.

    PubMed

    O'Brien, Stephen J; Johnson, Warren E

    2005-01-01

    Advances in population and quantitative genomics, aided by the computational algorithms that employ genetic theory and practice, are now being applied to biological questions that surround free-ranging species not traditionally suitable for genetic enquiry. Here we review how applications of molecular genetic tools have been used to describe the natural history, present status, and future disposition of wild cat species. Insight into phylogenetic hierarchy, demographic contractions, geographic population substructure, behavioral ecology, and infectious diseases have revealed strategies for survival and adaptation of these fascinating predators. Conservation, stabilization, and management of the big cats are important areas that derive benefit from the genome resources expanded and applied to highly successful species, imperiled by an expanding human population.

  3. The Last Big Bang

    SciTech Connect

    McGuire, Austin D.; Meade, Roger Allen

    2016-09-13

    As one of the very few people in the world to give the “go/no go” decision to detonate a nuclear device, Austin “Mac” McGuire holds a very special place in the history of both the Los Alamos National Laboratory and the world. As Commander of Joint Task Force Unit 8.1.1, on Christmas Island in the spring and summer of 1962, Mac directed the Los Alamos data collection efforts for twelve of the last atmospheric nuclear detonations conducted by the United States. Since data collection was at the heart of nuclear weapon testing, it fell to Mac to make the ultimate decision to detonate each test device. He calls his experience THE LAST BIG BANG, since these tests, part of Operation Dominic, were characterized by the dramatic displays of the heat, light, and sounds unique to atmospheric nuclear detonations – never, perhaps, to be witnessed again.

  4. Big bang and big crunch in matrix string theory

    SciTech Connect

    Bedford, J.; Ward, J.; Papageorgakis, C.; Rodriguez-Gomez, D.

    2007-04-15

    Following the holographic description of linear dilaton null cosmologies with a big bang in terms of matrix string theory put forward by Craps, Sethi, and Verlinde, we propose an extended background describing a universe including both big bang and big crunch singularities. This belongs to a class of exact string backgrounds and is perturbative in the string coupling far away from the singularities, both of which can be resolved using matrix string theory. We provide a simple theory capable of describing the complete evolution of this closed universe.

  5. Identifying possible sister groups of Cryptocercidae+Isoptera: a combined molecular and morphological phylogeny of Dictyoptera.

    PubMed

    Djernæs, Marie; Klass, Klaus-Dieter; Eggleton, Paul

    2015-03-01

    Termites (Isoptera) offer an alternative model for the development of eusociality which is not dependent on a high degree of relatedness as found between sisters in hymenopterans (bees, wasps, ants). Recent phylogenetic studies have established that termites belong within the cockroaches as sister to the subsocial Cryptocercidae. Cryptocercidae shares several important traits with termites, thus we need to understand the phylogenetic position of Cryptocercidae+Isoptera to determine how these traits evolved. However, placement of Cryptocercidae+Isoptera is still uncertain. We used both molecular (12S, 16S, COII, 18S, 28S, H3) and morphological characters to reconstruct the phylogeny of Dictyoptera. We included all previously suggested sister groups of Cryptocercidae+Isoptera as well as taxa which might represent additional major cockroach lineages. We used Bayes factors to test different sister groups for Cryptocercidae+Isoptera and assessed character support for the consensus tree based on morphological characters and COII amino acid data. We used the molecular data and fossil calibration to estimate divergence times. We found the most likely sister groups of Cryptocercidae+Isoptera to be Tryonicidae, Anaplecta or Tryonicidae+Anaplecta. Anaplecta has never previously been suggested as sister group or even close to Cryptocercidae+Isoptera, but was formerly placed in Blaberoidea as sister to the remaining taxa. Topological tests firmly supported our new placement of Anaplecta. We discuss the morphological characters (e.g. retractable genitalic hook) that have contributed to the previous placement of Anaplecta in Blaberoidea as well as the factors that might have contributed to a parallel development of genitalic features in Anaplecta and Blaberoidea. Cryptocercidae+Isoptera is placed in a clade with Tryonicidae, Anaplecta and possibly Lamproblattidae. Based on this, we suggest that wood-feeding, and the resultant need to conserve nitrogen, may have been an important

  6. Digital Data for Volcano Hazards of the Three Sisters Region, Oregon

    USGS Publications Warehouse

    Schilling, S.P.; Doelger, S.; Scott, W.E.; Iverson, R.M.

    2008-01-01

    Three Sisters is one of three active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. The major composite volcanoes of this area are clustered near the center of the region and include South Sister, Middle Sister, and Broken Top. Additionally, hundreds of mafic volcanoes are scattered throughout the Three Sisters area. These range from small cinder cones to large shield volcanoes like North Sister and Belknap Crater. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three Sisters and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three Sisters and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the Cascade Range also contribute to volcano hazards in Central Oregon. Scientists at the Cascades Volcano Observatory created a geographic information system (GIS) data set which depicts proximal and distal lahar hazard zones as well as a regional lava flow hazard zone for Three Sisters (USGS Open-File Report 99-437, Scott and others, 1999). The various distal lahar zones were constructed from LaharZ software using 20, 100, and 500 million cubic meter input flow volumes. Additionally, scientists used the depositional history of past events in the Three Sisters Region as well as experience and judgment derived from the

  7. Sisters Unbound Is Required for Meiotic Centromeric Cohesion in Drosophila melanogaster

    PubMed Central

    Krishnan, Badri; Thomas, Sharon E.; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B.; McKee, Bruce D.

    2014-01-01

    Regular meiotic chromosome segregation requires sister centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when sister chromatids segregate. Both orientation patterns require cohesion between sister centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called sisters unbound (sunn), which is required for stable sister chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162

  8. Sister cohesion and structural axis components mediate homolog bias of meiotic recombination

    PubMed Central

    Kim, Keun P.; Weiner, Beth M.; Zhang, Liangran; Jordan, Amy; Dekker, Job; Kleckner, Nancy

    2010-01-01

    SUMMARY Meiotic recombination occurs between one chromatid of each maternal and paternal homolog (homolog bias) versus between sister chromatids (sister bias). Physical DNA analysis reveals that meiotic cohesin/axis component Rec8 promotes sister bias, likely via its cohesion activity. Two meiosis-specific axis components, Red1/Mek1kinase, counteract this effect. With this precondition satisfied, other molecules directly specify homolog bias per se. Rec8 also acts positively to maintain homolog bias during crossover recombination. These observations point to sequential release of double-strand break ends from association with their sister. Red1 and Rec8 are found to play distinct roles for sister cohesion, DSB formation and recombination progression kinetics. Also, the two components are enriched in spatially distinct domains of axial structure that develop prior to DSB formation. We propose that Red1 and Rec8 domains provide functionally complementary environments whereby inputs evolved from DSB repair and late-stage chromosome morphogenesis are integrated to give the complete meiotic chromosomal program. PMID:21145459

  9. Neuropsychological profiles of three sisters homozygous for the fragile X premutation

    SciTech Connect

    Mazzocco, M.M.M.; Holden, J.J.A.

    1996-08-09

    Fragile X syndrome (fraX) is associated with an amplification of a CGG repeat within the fraX mental retardation (FMR-1) gene. We describe an exceptional family in which 3 adult sisters are homozygous for the FMR-1 premutation. Each sister inherited 2 premutation alleles (ca. 80 CGG repeats) from their biologically unrelated parents. The 3 sisters were administered measures of executive function, visual spatial, memory, and verbal skills. Deficiencies in the first 2 of these domains have been reported among females with the full mutation. The sisters` performances were compared with available normative data and with published group means for females affected by fraX. These women did not appear to have verbal or memory difficulties. None of the women demonstrated a global executive function deficit, and none had global deficits in spatial ability. The profiles of these sisters are consistent with reports that the fragile X premutation does not affect cognitive performance. 31 refs., 1 fig., 4 tabs.

  10. Mechanics of Sister Chromatids studied with a Polymer Model English</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Yang; Isbaner, Sebastian; Heermann, Dieter</p> <p>2013-10-01</p> <p><span class="hlt">Sister</span> chromatid cohesion denotes the phenomenon that <span class="hlt">sister</span> chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain <span class="hlt">sister</span> chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of <span class="hlt">sister</span> chromatids by means of computer simulations. We model both protein-mediated cohesion between <span class="hlt">sister</span> chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific link concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4687580','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4687580"><span>Genomic data do not support comb jellies as the <span class="hlt">sister</span> group to all other animals</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert</p> <p>2015-01-01</p> <p>Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the <span class="hlt">sister</span> group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the <span class="hlt">sister</span> group to the remaining animals (the “Ctenophora-sister” hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-<span class="hlt">sister</span>, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-<span class="hlt">sister</span> and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-<span class="hlt">sister</span> hypothesis are not supported by the currently available data. PMID:26621703</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25194162','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25194162"><span><span class="hlt">Sisters</span> unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krishnan, Badri; Thomas, Sharon E; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B; McKee, Bruce D</p> <p>2014-11-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21171768','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21171768"><span>Links between <span class="hlt">sisters</span>' sexual and dating victimization: the roles of neighborhood crime and parental controls.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>East, Patricia L; Chien, Nina C; Adams, Joyce A; Hokoda, Audrey; Maier, Ashley</p> <p>2010-12-01</p> <p>This study examined the extent to which a <span class="hlt">sister</span>'s prior sexual and dating victimization is a risk factor for young women being similarly victimized and the possible factors underlying a co-occurrence. The sample involved 122 young adult Latina or African American <span class="hlt">sister</span> pairs (244 women; ages 16-25) who resided in low-income, urban neighborhoods. Results indicated that women whose <span class="hlt">sisters</span> had been victimized had increased risk of victimization even after controlling for neighborhood crime, parental controls, age and race-ethnicity (odds ratios were 4.0 for unwanted touching, 6.2 for a forced sex act, and 16.7 for dating violence). In high-crime neighborhoods, the presence of two adult parent figures in the home was associated with women's reduced likelihood of unwanted touching, and mothers' high monitoring during adolescence was associated with women's lower risk of dating aggression. Survival analysis results showed that the risk period of a second <span class="hlt">sister</span> being victimized lasts between 7 and 10 years after a first <span class="hlt">sister</span>'s victimization. The prevention implications of study findings are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15955849','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15955849"><span>Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in <span class="hlt">sister</span> chromatid cohesion.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Skibbens, Robert V</p> <p>2005-06-20</p> <p>It is well known that the products of chromosome replication are paired to ensure that the <span class="hlt">sisters</span> segregate away from each other during mitosis. A key issue is how cells pair <span class="hlt">sister</span> chromatids but preclude the catastrophic pairing of nonsister chromatids. The identification of both replication factor C and DNA helicases as critical for <span class="hlt">sister</span> chromatid pairing has brought new insights into this fundamental process.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..APR.H3011C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..APR.H3011C"><span><span class="hlt">Big</span> Bang of Massenergy and Negative <span class="hlt">Big</span> Bang of Spacetime</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Cao, Dayong</p> <p>2017-01-01</p> <p>There is a balance between <span class="hlt">Big</span> Bang of Massenergy and Negative <span class="hlt">Big</span> Bang of Spacetime in the universe. Also some scientists considered there is an anti-<span class="hlt">Big</span> Bang who could produce the antimatter. And the paper supposes there is a structure balance between Einstein field equation and negative Einstein field equation, a balance between massenergy structure and spacetime structure, a balance between an energy of nucleus of the stellar matter and a dark energy of nucleus of the dark matter-dark energy, and a balance between the particle and the wave-a balance system between massenergy (particle) and spacetime (wave). It should explain of the problems of the <span class="hlt">Big</span> Bang. http://meetings.aps.org/Meeting/APR16/Session/M13.8</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA625699','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA625699"><span>Acquisition Reform: Three <span class="hlt">Big</span> Ideas</span></a></p> <p><a target="_blank" href="https://publicaccess.dtic.mil/psm/api/service/search/search">DTIC Science & Technology</a></p> <p></p> <p>2015-05-19</p> <p>Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Three Acq Reform <span class="hlt">Big</span> Ideas 5 /19/2015 2 (1) Competing Capability Needs Among Services...to sponsor and users • Not required to be an acquisition expert • Tenure not as important Summary: 3 <span class="hlt">Big</span> Ideas 5 /19/2015 19 (1) Competing...Acquisition Reform Three <span class="hlt">Big</span> Ideas The provocative views expressed here are not those of the Department of Defense, DAU, or perhaps even the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4272234','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4272234"><span><span class="hlt">Big</span> Data and Ambulatory Care</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Thorpe, Jane Hyatt; Gray, Elizabeth Alexandra</p> <p>2015-01-01</p> <p><span class="hlt">Big</span> data is heralded as having the potential to revolutionize health care by making large amounts of data available to support care delivery, population health, and patient engagement. Critics argue that <span class="hlt">big</span> data's transformative potential is inhibited by privacy requirements that restrict health information exchange. However, there are a variety of permissible activities involving use and disclosure of patient information that support care delivery and management. This article presents an overview of the legal framework governing health information, dispels misconceptions about privacy regulations, and highlights how ambulatory care providers in particular can maximize the utility of <span class="hlt">big</span> data to improve care. PMID:25401945</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4892667','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4892667"><span>The challenges of <span class="hlt">big</span> data</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2016-01-01</p> <p>ABSTRACT The largely untapped potential of <span class="hlt">big</span> data analytics is a feeding frenzy that has been fueled by the production of many next-generation-sequencing-based data sets that are seeking to answer long-held questions about the biology of human diseases. Although these approaches are likely to be a powerful means of revealing new biological insights, there are a number of substantial challenges that currently hamper efforts to harness the power of <span class="hlt">big</span> data. This Editorial outlines several such challenges as a means of illustrating that the path to <span class="hlt">big</span> data revelations is paved with perils that the scientific community must overcome to pursue this important quest. PMID:27147249</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/20713708','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/20713708"><span>Homogeneous and isotropic <span class="hlt">big</span> rips?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Giovannini, Massimo</p> <p>2005-10-15</p> <p>We investigate the way <span class="hlt">big</span> rips are approached in a fully inhomogeneous description of the space-time geometry. If the pressure and energy densities are connected by a (supernegative) barotropic index, the spatial gradients and the anisotropic expansion decay as the <span class="hlt">big</span> rip is approached. This behavior is contrasted with the usual <span class="hlt">big</span>-bang singularities. A similar analysis is performed in the case of sudden (quiescent) singularities and it is argued that the spatial gradients may well be non-negligible in the vicinity of pressure singularities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5192484','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5192484"><span>Novel PIGT Variant in Two <span class="hlt">Brothers</span>: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skauli, Nadia; Wallace, Sean; Chiang, Samuel C. C.; Barøy, Tuva; Holmgren, Asbjørn; Stray-Pedersen, Asbjørg; Bryceson, Yenan T.; Strømme, Petter; Frengen, Eirik; Misceo, Doriana</p> <p>2016-01-01</p> <p>Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmorphisms, and skeletal, ophthalmological, cardiac, and genitourinary abnormalities. We report a novel homozygous PIGT missense variant c.1079G>T (p.Gly360Val) in two <span class="hlt">brothers</span> with several of the typical features of MCAHS3, but in addition, pyramidal tract neurological signs. Notably, they are the first patients with MCAHS3 without skeletal, cardiac, or genitourinary anomalies. PIGT encodes a crucial subunit of the glycosylphosphatidylinositol (GPI) transamidase complex, which catalyzes the attachment of proteins to GPI-anchors, attaching the proteins to the cell membrane. In vitro studies in cells from the two <span class="hlt">brothers</span> showed reduced levels of GPI-anchors and GPI-anchored proteins on the cell surface, supporting the pathogenicity of the novel PIGT variant. PMID:27916860</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005NW.....92..586B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005NW.....92..586B"><span>Osteological evidence for <span class="hlt">sister</span> group relationship between pseudo-toothed birds (Aves: Odontopterygiformes) and waterfowls (Anseriformes)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bourdon, Estelle</p> <p>2005-12-01</p> <p>The phylogenetic affinities of the extinct pseudo-toothed birds have remained controversial. Some authors noted that they resemble both pelicans and allies (Pelecaniformes) and tube-nosed birds (Procellariiformes), but assigned them to a distinct taxon, the Odontopterygiformes. In most recent studies, the pseudo-toothed birds are referred to the family Pelagornithidae inside the Pelecaniformes. Here, I perform a cladistic analysis with five taxa of the pseudo-toothed birds including two undescribed new species from the Early Tertiary of Morocco. The present hypothesis strongly supports a <span class="hlt">sister</span> group relationship of pseudo-toothed birds (Odontopterygiformes) and waterfowls (Anseriformes). The Odontoanserae (Odontopterygiformes plus Anseriformes) are the <span class="hlt">sister</span> group of Neoaves. The placement of the landfowls (Galliformes) as the <span class="hlt">sister</span> taxon of all other neognathous birds does not support the consensus view that the Galloanserae (Galliformes plus Anseriformes) are monophyletic.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9730567','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9730567"><span>A case of IgA nephropathy in three <span class="hlt">sisters</span> with thin basement membrane disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yoshida, K; Suzuki, J; Suzuki, S; Kume, K; Suzuki, H; Hujiki, T</p> <p>1998-01-01</p> <p>IgA nephropathy associated with thin basement membrane disease is reported in a 9-year-old female. The diagnosis of IgA nephropathy was made by means of an immunofluorescence investigation, which showed generalized diffuse mesangial deposits. Thin basement membrane disease was identified by electron-microscopic investigations, which disclosed thinning of the basement membrane of several capillary loops and prominence of the lamina densa. Her father, elder <span class="hlt">sister</span> and younger <span class="hlt">sister</span> were also found to have hematuria and her <span class="hlt">sisters</span> were diagnosed as having thin basement membrane disease by renal biopsy. Patients with IgA nephropathy have focal thinning of the glomerular basement membrane, but we consider that urinalysis of the family needs to be done for the diagnosis of familial thin basement membrane disease, when diffuse thinning of the glomerular basement membrane is detected in such patients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16240103','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16240103"><span>Osteological evidence for <span class="hlt">sister</span> group relationship between pseudo-toothed birds (Aves: Odontopterygiformes) and waterfowls (Anseriformes).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bourdon, Estelle</p> <p>2005-12-01</p> <p>The phylogenetic affinities of the extinct pseudo-toothed birds have remained controversial. Some authors noted that they resemble both pelicans and allies (Pelecaniformes) and tube-nosed birds (Procellariiformes), but assigned them to a distinct taxon, the Odontopterygiformes. In most recent studies, the pseudo-toothed birds are referred to the family Pelagornithidae inside the Pelecaniformes. Here, I perform a cladistic analysis with five taxa of the pseudo-toothed birds including two undescribed new species from the Early Tertiary of Morocco. The present hypothesis strongly supports a <span class="hlt">sister</span> group relationship of pseudo-toothed birds (Odontopterygiformes) and waterfowls (Anseriformes). The Odontoanserae (Odontopterygiformes plus Anseriformes) are the <span class="hlt">sister</span> group of Neoaves. The placement of the landfowls (Galliformes) as the <span class="hlt">sister</span> taxon of all other neognathous birds does not support the consensus view that the Galloanserae (Galliformes plus Anseriformes) are monophyletic.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10480213','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10480213"><span>Subcortical laminar heterotopia in two <span class="hlt">sisters</span> and their mother: MRI, clinical findings and pathogenesis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>van der Valk, P H; Snoeck, I; Meiners, L C; des Portes, V; Chelly, J; Pinard, J M; Ippel, P F; van Nieuwenhuizen, O; Peters, A C</p> <p>1999-06-01</p> <p>MR imaging, clinical data and underlying pathogenesis of subcortical laminar heterotopia (SCLH), also known as band heterotopia, in two <span class="hlt">sisters</span> and their mother are presented. On MR imaging a different degree of SCLH was found in all three affected family-members. The inversion recovery sequence was considered most useful in the demonstration of the heterotopic band of gray matter and the assessment of cortical thickness. The younger <span class="hlt">sister</span> presented with epileptic seizures at the age of five months and a delayed achievement of developmental milestones. The older <span class="hlt">sister</span> of seven years had epileptic seizures since the age of one year, and developmental delay. Their mother has only had one seizure-like episode at the age of 39. Her psychomotor development had been normal. Investigation of DNA samples of the three female family-members revealed a mutation in the X-linked doublecortin gene. Within families with band heterotopia, this gene has also been related to male family members with lissencephaly.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/6839185','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/6839185"><span>Superfund Record of Decision (EPA Region 4): Mathis <span class="hlt">Brothers</span> Landfill (South Marble Top Road), Walker County, GA, March 1993</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1993-03-01</p> <p>This decision document (Record of Decision) presents the selected remedial action for the Mathis <span class="hlt">Brothers</span> - South Marble Top Road Landfill site, Walker County, Georgia. At this time the remedial action is proposed as both the first, and the final remedial action for the site. The function of this remedy is to treat contamination and reduce it to health based levels. Source material and contaminated soils are the principal threat at the site.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28318975','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28318975"><span>A Large and Consistent Phylogenomic Dataset Supports Sponges as the <span class="hlt">Sister</span> Group to All Other Animals.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Simion, Paul; Philippe, Hervé; Baurain, Denis; Jager, Muriel; Richter, Daniel J; Di Franco, Arnaud; Roure, Béatrice; Satoh, Nori; Quéinnec, Éric; Ereskovsky, Alexander; Lapébie, Pascal; Corre, Erwan; Delsuc, Frédéric; King, Nicole; Wörheide, Gert; Manuel, Michaël</p> <p>2017-04-03</p> <p>Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera) are the <span class="hlt">sister</span> group to all other animals ("Porifera-<span class="hlt">sister</span>" hypothesis), consistent with a single origin of the gut, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnidarians). In contrast, several other studies have recovered an alternative topology in which ctenophores are the <span class="hlt">sister</span> group to all other animals (including sponges). The "Ctenophora-<span class="hlt">sister</span>" hypothesis implies that eumetazoan-specific traits, such as neurons and muscle cells, either evolved once along the metazoan stem lineage and were then lost in sponges and placozoans or evolved at least twice independently in Ctenophora and in Cnidaria + Bilateria. Here, we report on our reconstruction of deep metazoan relationships using a 1,719-gene dataset with dense taxonomic sampling of non-bilaterian animals that was assembled using a semi-automated procedure, designed to reduce known error sources. Our dataset outperforms previous metazoan gene superalignments in terms of data quality and quantity. Analyses with a best-fitting site-heterogeneous evolutionary model provide strong statistical support for placing sponges as the <span class="hlt">sister</span>-group to all other metazoans, with ctenophores emerging as the second-earliest branching animal lineage. Only those methodological settings that exacerbated long-branch attraction artifacts yielded Ctenophora-<span class="hlt">sister</span>. These results show that methodological issues must be carefully addressed to tackle difficult phylogenetic questions and pave the road to a better understanding of how fundamental features of animal body plans have emerged.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014Natur.506..249L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014Natur.506..249L"><span>RecA bundles mediate homology pairing between distant <span class="hlt">sisters</span> during DNA break repair</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J.</p> <p>2014-02-01</p> <p>DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant <span class="hlt">sister</span> loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one <span class="hlt">sister</span> can be repaired efficiently using distant <span class="hlt">sister</span> homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut <span class="hlt">sister</span>. After <span class="hlt">sister</span> locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in <span class="hlt">sister</span> pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27692075','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27692075"><span><span class="hlt">Big</span> Data and Perioperative Nursing.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Westra, Bonnie L; Peterson, Jessica J</p> <p>2016-10-01</p> <p><span class="hlt">Big</span> data are large volumes of digital data that can be collected from disparate sources and are challenging to analyze. These data are often described with the five "Vs": volume, velocity, variety, veracity, and value. Perioperative nurses contribute to <span class="hlt">big</span> data through documentation in the electronic health record during routine surgical care, and these data have implications for clinical decision making, administrative decisions, quality improvement, and <span class="hlt">big</span> data science. This article explores methods to improve the quality of perioperative nursing data and provides examples of how these data can be combined with broader nursing data for quality improvement. We also discuss a national action plan for nursing knowledge and <span class="hlt">big</span> data science and how perioperative nurses can engage in collaborative actions to transform health care. Standardized perioperative nursing data has the potential to affect care far beyond the original patient.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1027233','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1027233"><span>The <span class="hlt">Big</span>BOSS Experiment</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna</p> <p>2011-01-01</p> <p><span class="hlt">Big</span>BOSS will obtain observational constraints that will bear on three of the four 'science frontier' questions identified by the Astro2010 Cosmology and Fundamental Phyics Panel of the Decadal Survey: Why is the universe accelerating; what is dark matter and what are the properties of neutrinos? Indeed, the <span class="hlt">Big</span>BOSS project was recommended for substantial immediate R and D support the PASAG report. The second highest ground-based priority from the Astro2010 Decadal Survey was the creation of a funding line within the NSF to support a 'Mid-Scale Innovations' program, and it used <span class="hlt">Big</span>BOSS as a 'compelling' example for support. This choice was the result of the Decadal Survey's Program Priorization panels reviewing 29 mid-scale projects and recommending <span class="hlt">Big</span>BOSS 'very highly'.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=PIA09077&hterms=Blueberries&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DBlueberries','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=PIA09077&hterms=Blueberries&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DBlueberries"><span><span class="hlt">Big</span> Spherules near 'Victoria'</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p></p> <p>2006-01-01</p> <p><p/> This frame from the microscopic imager on NASA's Mars Exploration Rover Opportunity shows spherules up to about 5 millimeters (one-fifth of an inch) in diameter. The camera took this image during the 924th Martian day, or sol, of Opportunity's Mars-surface mission (Aug. 30, 2006), when the rover was about 200 meters (650 feet) north of 'Victoria Crater.' <p/> Opportunity discovered spherules like these, nicknamed 'blueberries,' at its landing site in 'Eagle Crater,' and investigations determined them to be iron-rich concretions that formed inside deposits soaked with groundwater. However, such concretions were much smaller or absent at the ground surface along much of the rover's trek of more than 5 kilometers (3 miles) southward to Victoria. The <span class="hlt">big</span> ones showed up again when Opportunity got to the ring, or annulus, of material excavated and thrown outward by the impact that created Victoria Crater. Researchers hypothesize that some layer beneath the surface in Victoria's vicinity was once soaked with water long enough to form the concretions, that the crater-forming impact dispersed some material from that layer, and that Opportunity might encounter that layer in place if the rover drives down into the crater.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25416555','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25416555"><span>Two <span class="hlt">brothers</span>' alleged paternity for a child: who is the father?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dogan, Muhammed; Kara, Umut; Emre, Ramazan; Fung, Wing Kam; Canturk, Kemal Murat</p> <p>2015-06-01</p> <p>In paternity cases where individuals are close relatives, it may be necessary to evaluate mother's DNA profile (trio test) and to increase the number of polymorphic STR loci that are analyzed. In our case, two alleged fathers who are <span class="hlt">brothers</span> and the child (duo case) were analyzed based on 20 STR loci; however, no exclusions could be achieved. Then trio test (with mother) was performed using the Identifiler Plus kit (Applied Biosystems) and no exclusions could be achieved again. Analysis performed with the ESS Plex Plus kit (Qiagen), the paternity of one of the two alleged fathers was rejected only on 2 STR loci. We made the calculations of power of exclusion values to interpret our results more properly. The probability of exclusion (PE) is calculated as 0.9776546 in 15 loci of Identifiler Plus kit without mother. The PE is calculated as 0.9942803, if 5 additional loci from ESS Plex Plus kit are typed. The PE becomes 0.9961048 for the Identifiler Plus kit in trio analysis. If both Identifiler Plus and ESS Plex Plus kits are used for testing, the PE is calculated as 0.999431654, which indicates that the combined kits are highly discriminating.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5241680','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5241680"><span><span class="hlt">Brother</span> of Regulator of Imprinted Sites (BORIS) suppresses apoptosis in colorectal cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhang, Yanmei; Fang, Mengdie; Song, Yongfei; Ren, Juan; Fang, Jianfei; Wang, Xiaoju</p> <p>2017-01-01</p> <p>Identifying oncogenes that promote cancer cell proliferation or survival is critical for treatment of colorectal cancer. The <span class="hlt">Brother</span> of Regulator of Imprinted Sites (BORIS) is frequently expressed in most types of cancer, but rarely in normal tissues. Aberrantly expressed BORIS relates to colorectal cancer, but its function in colorectal cancer cells remains unclear. In addition, previous studies indicated the significance of cytoplasm-localized BORIS in cancer cells. However, none of them investigated its function. Herein, we investigated the functions of BORIS in cancer cell proliferation and apoptosis and the role of cytoplasm-localized BORIS in colorectal cancer. BORIS expression correlated with colorectal cancer proliferation. BORIS overexpression promoted colorectal cancer cell growth, whereas BORIS knockdown suppressed cell proliferation. Sensitivity of colorectal cancer cells to 5-fluorouracil (5-FU) was inversely correlated with BORIS expression. These data suggest that BORIS functions as an oncogene in colorectal cancer. BORIS silencing induced reactive oxygen species (ROS) production and apoptosis, whereas BORIS supplementation inhibited apoptosis induced by BORIS short interfering RNA (siRNA), hydrogen peroxide (H2O2) or 5-FU. Introduction of BORIS-ZFdel showed that cytoplasmic localization of BORIS inhibited apoptosis but not ROS production. Our study highlights the anti-apoptotic function of BORIS in colorectal cancer. PMID:28098226</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23332130','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23332130"><span>Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two <span class="hlt">brothers</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cerbone, Manuela; Agretti, Patrizia; De Marco, Giuseppina; Improda, Nicola; Pignata, Claudio; Santamaria, Francesca; Tonacchera, Massimo; Salerno, Mariacarolina</p> <p>2013-01-19</p> <p>Subclinical hypothyroidism (SH) is a condition characterized by a mild persistent thyroid failure. The main cause is represented by autoimmune thyroiditis, but mutations in genes encoding proteins involved in TSH pathway are thought to be responsible for SH, particularly in cases arising in familial settings. Patients with the syndrome of TSH unresponsiveness may have compensated or overt hypothyroidism with a wide spectrum of clinical and morphological alterations depending on the degree of impairment of TSH-receptor (TSH-R) function. We describe the case of two <span class="hlt">brothers</span> with non autoimmune SH carrying the same heterozygous mutation in the extracellular domain of TSH-R and presenting with different clinical, biochemical and morphological features. The first one had only a slight persistent elevation of TSH, a normal thyroid ultrasound and did never require l- thyroxine (L-T4) replacement treatment. The second one had a neonatal persistent moderate TSH levels increase associated with a thyroid gland hypoplasia and was treated with L-T4 since the first months of life.These two cases support the recent association of TSH-R mutations inheritance as an autosomal dominant pattern with variable expressivity and suggest that the decision to start replacement therapy in patients with persistent SH due to TSH resistance should be individualized.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24670344','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24670344"><span>Vitamin D intoxication in two <span class="hlt">brothers</span>: be careful with dietary supplements.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Conti, Giovanni; Chirico, Valeria; Lacquaniti, Antonio; Silipigni, Lorena; Fede, Claudia; Vitale, Agata; Fede, Carmelo</p> <p>2014-07-01</p> <p>Vitamin D (VitD) intoxication, a well-known cause of hypercalcaemia in children, has renal, cardiac and neurological consequences. Iatrogenic or accidental administrations are the most common causes. We present two cases of hypervitaminosis D due to over-the-counter VitD supplement self-medication. A 12-year-old boy was hospitalised for abdominal pain, constipation and vomiting. Routine biochemistry indicated severe hypercalcaemia and renal failure. Plasma 25-OH VitD level was very high and parathyroid hormone was suppressed. Renal ultrasound showed nephrolithiasis. Hydration, diuretics and prednisone induced a progressive reduction of calcium levels. His <span class="hlt">brother</span>, who was receiving the same treatment, was hospitalised although asymptomatic. Normal serum calcium and renal function were revealed, while 25-OH VitD was high and parathyroid hormone was suppressed. Renal ultrasound was within the normal range. Examination of the VitD content of the over-the-counter supplement revealed a higher amount than declared. VitD administration implies several risks and must be prescribed only when needed and under strict medical control.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26297769','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26297769"><span>Gorlin-Goltz syndrome in twin <span class="hlt">brothers</span>: an unusual occurrence with review of the literature.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Anchlia, Sonal; Vyas, Siddharth; Bahl, Sumit; Nagavadiya, Vipul</p> <p>2015-08-21</p> <p>Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is caused by genetic alteration produced by a mutation in the 'patched' tumour suppressor gene, and is inherited in a dominant autosomal way. Although sporadic cases have been found, this syndrome has rarely been reported in twin patients. The syndrome is characterised by a wide range of developmental abnormalities and has a predisposition to neoplasms such as multiple pigmented basal cell carcinomas and keratocysts in jaws; it also has other features such as palmar and/or plantar pits and calcification of falx cerebri. Owing to the critical oral and maxillofacial manifestations of this syndrome, it is important to recognise its characteristics in order to make a diagnosis, and to plot early preventive treatment and establish the right genetic evidence. Based on a combination of imaging, clinical and histopathological findings, we present a diagnosed case of Gorlin-Goltz syndrome in 18-year-old twin <span class="hlt">brothers</span>. All cystic lesions were enucleated and 1 year follow-up showed no recurrence.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10668620','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10668620"><span>Reconstructing the <span class="hlt">Brothers</span> Grimm: new tales for step-family life.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bernstein, A C</p> <p>1999-01-01</p> <p>Step-families are situated within the sociopolitical context of family change and are examined as a prototype of the "post-modern" family. This essay looks at the cultural construction of step-family life and proposes a model for collaboratively reconstructing stories that liberate step-relationships from the legacy of the <span class="hlt">Brothers</span> Grimm, deconstructing the stories of failure, insufficiency, and neglect. Building on narrative and social constructionist ways of thinking about families, the concept of side-shadowing (a hermeneutic approach from literary/historical criticism) is introduced to elucidate how therapists can help family members discover ways of thinking, feeling, and behaving that are both more personally satisfying and more congruent with the changed context of family life. Two therapeutic challenges are high-lighted: reconceptualizing what it means to be a step-family and coming to terms with differential attachment in relationships while working with step-families. The essay ends with a fairy tale for the 21st century.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25419469','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25419469"><span>Challenges of <span class="hlt">Big</span> Data Analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fan, Jianqing; Han, Fang; Liu, Han</p> <p>2014-06-01</p> <p><span class="hlt">Big</span> Data bring new opportunities to modern society and challenges to data scientists. On one hand, <span class="hlt">Big</span> Data hold great promises for discovering subtle population patterns and heterogeneities that are not possible with small-scale data. On the other hand, the massive sample size and high dimensionality of <span class="hlt">Big</span> Data introduce unique computational and statistical challenges, including scalability and storage bottleneck, noise accumulation, spurious correlation, incidental endogeneity, and measurement errors. These challenges are distinguished and require new computational and statistical paradigm. This article gives overviews on the salient features of <span class="hlt">Big</span> Data and how these features impact on paradigm change on statistical and computational methods as well as computing architectures. We also provide various new perspectives on the <span class="hlt">Big</span> Data analysis and computation. In particular, we emphasize on the viability of the sparsest solution in high-confidence set and point out that exogeneous assumptions in most statistical methods for <span class="hlt">Big</span> Data can not be validated due to incidental endogeneity. They can lead to wrong statistical inferences and consequently wrong scientific conclusions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4236847','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4236847"><span>Challenges of <span class="hlt">Big</span> Data Analysis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fan, Jianqing; Han, Fang; Liu, Han</p> <p>2014-01-01</p> <p><span class="hlt">Big</span> Data bring new opportunities to modern society and challenges to data scientists. On one hand, <span class="hlt">Big</span> Data hold great promises for discovering subtle population patterns and heterogeneities that are not possible with small-scale data. On the other hand, the massive sample size and high dimensionality of <span class="hlt">Big</span> Data introduce unique computational and statistical challenges, including scalability and storage bottleneck, noise accumulation, spurious correlation, incidental endogeneity, and measurement errors. These challenges are distinguished and require new computational and statistical paradigm. This article gives overviews on the salient features of <span class="hlt">Big</span> Data and how these features impact on paradigm change on statistical and computational methods as well as computing architectures. We also provide various new perspectives on the <span class="hlt">Big</span> Data analysis and computation. In particular, we emphasize on the viability of the sparsest solution in high-confidence set and point out that exogeneous assumptions in most statistical methods for <span class="hlt">Big</span> Data can not be validated due to incidental endogeneity. They can lead to wrong statistical inferences and consequently wrong scientific conclusions. PMID:25419469</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26340243','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26340243"><span>Powering <span class="hlt">Big</span> Data for Nursing Through Partnership.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Harper, Ellen M; Parkerson, Sara</p> <p>2015-01-01</p> <p>The <span class="hlt">Big</span> Data Principles Workgroup (Workgroup) was established with support of the Healthcare Information and Management Systems Society. Building on the Triple Aim challenge, the Workgroup sought to identify <span class="hlt">Big</span> Data principles, barriers, and challenges to nurse-sensitive data inclusion into <span class="hlt">Big</span> Data sets. The product of this pioneering partnership Workgroup was the "Guiding Principles for <span class="hlt">Big</span> Data in Nursing-Using <span class="hlt">Big</span> Data to Improve the Quality of Care and Outcomes."</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=turner+AND+syndrome&pg=2&id=EJ579567','ERIC'); return false;" href="http://eric.ed.gov/?q=turner+AND+syndrome&pg=2&id=EJ579567"><span>Social Functioning among Girls with Fragile X or Turner Syndrome and Their <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.</p> <p>1998-01-01</p> <p>Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their <span class="hlt">sisters</span>, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531','ERIC'); return false;" href="http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531"><span>Meanings of Sisterhood and Developmental Disability: Narratives from White Nondisabled <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McGraw, Lori A.; Walker, Alexis J.</p> <p>2007-01-01</p> <p>Integrating thought from critical feminist and disability theorists via a strategic social constructionist perspective, the authors analyzed 10 in-depth qualitative interviews to begin to understand the dialogue between (a) how nondisabled <span class="hlt">sisters</span> understand themselves and their siblings with developmental disabilities and (b) wider systems of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28254474','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28254474"><span>New insights on the <span class="hlt">sister</span> lineage of percomorph fishes with an anchored hybrid enrichment dataset.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dornburg, Alex; Townsend, Jeffrey P; Brooks, Willa; Spriggs, Elizabeth; Eytan, Ron I; Moore, Jon A; Wainwright, Peter C; Lemmon, Alan; Lemmon, Emily Moriarty; Near, Thomas J</p> <p>2017-02-27</p> <p>Percomorph fishes represent over 17,100 species, including several model organisms and species of economic importance. Despite continuous advances in the resolution of the percomorph Tree of Life, resolution of the <span class="hlt">sister</span> lineage to Percomorpha remains inconsistent but restricted to a small number of candidate lineages. Here we use an anchored hybrid enrichment (AHE) dataset of 132 loci with over 99,000 base pairs to identify the <span class="hlt">sister</span> lineage of percomorph fishes. Initial analyses of this dataset failed to recover a strongly supported <span class="hlt">sister</span> clade to Percomorpha, however, scrutiny of the AHE dataset revealed a bias towards high GC content at fast-evolving codon partitions (GC bias). By combining several existing approaches aimed at mitigating the impacts of convergence in GC bias, including RY coding and analyses of amino acids, we consistently recovered a strongly supported clade comprised of Holocentridae (squirrelfishes), Berycidae (Alfonsinos), Melamphaidae (bigscale fishes), Cetomimidae (flabby whalefishes), and Rondeletiidae (redmouth whalefishes) as the <span class="hlt">sister</span> lineage to Percomorpha. Additionally, implementing phylogenetic informativeness (PI) based metrics as a filtration method yielded this same topology, suggesting PI based approaches will preferentially filter these fast-evolving regions and act in a manner consistent with other phylogenetic approaches aimed at mitigating GC bias. Our results provide a new perspective on a key issue for studies investigating the evolutionary history of more than one quarter of all living species of vertebrates.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Beans&pg=4&id=EJ797780','ERIC'); return false;" href="http://eric.ed.gov/?q=Beans&pg=4&id=EJ797780"><span>Three <span class="hlt">Sisters</span>: Lessons of Traditional Story Honored in Assessment and Accreditation</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenault, Venida S.</p> <p>2008-01-01</p> <p>The three <span class="hlt">sisters</span> story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in tribal…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1461834','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1461834"><span>Genes involved in <span class="hlt">sister</span> chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Biggins, S; Bhalla, N; Chang, A; Smith, D L; Murray, A W</p> <p>2001-01-01</p> <p>Accurate chromosome segregation requires the precise coordination of events during the cell cycle. Replicated <span class="hlt">sister</span> chromatids are held together while they are properly attached to and aligned by the mitotic spindle at metaphase. At anaphase, the links between <span class="hlt">sisters</span> must be promptly dissolved to allow the mitotic spindle to rapidly separate them to opposite poles. To isolate genes involved in chromosome behavior during mitosis, we microscopically screened a temperature-sensitive collection of budding yeast mutants that contain a GFP-marked chromosome. Nine LOC (loss of cohesion) complementation groups that do not segregate <span class="hlt">sister</span> chromatids at anaphase were identified. We cloned the corresponding genes and performed secondary tests to determine their function in chromosome behavior. We determined that three LOC genes, PDS1, ESP1, and YCS4, are required for <span class="hlt">sister</span> chromatid separation and three other LOC genes, CSE4, IPL1, and SMT3, are required for chromosome segregation. We isolated alleles of two genes involved in splicing, PRP16 and PRP19, which impair alpha-tubulin synthesis thus preventing spindle assembly, as well as an allele of CDC7 that is defective in DNA replication. We also report an initial characterization of phenotypes associated with the SMT3/SUMO gene and the isolation of WSS1, a high-copy smt3 suppressor. PMID:11606525</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=chess&pg=3&id=EJ939604','ERIC'); return false;" href="http://eric.ed.gov/?q=chess&pg=3&id=EJ939604"><span>Does High-Level Intellectual Performance Depend on Practice Alone? Debunking the Polgar <span class="hlt">Sisters</span> Case</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Howard, Robert W.</p> <p>2011-01-01</p> <p>The famous Polgar <span class="hlt">sisters</span> started chess very young, undertook extensive study, and two became grandmasters. This case often is cited as decisive evidence that practice alone is key in development of expertise, that innate talent is unimportant or non-existent, and that almost anyone can become a grandmaster. But on close examination these claims…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED404313.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED404313.pdf"><span><span class="hlt">Sister</span> Schools: An Experience in Culture Vision for Preservice Teachers and Elementary Children.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Black, Sharon J.; Cutler, Beverly R.</p> <p></p> <p>The School of Education at Brigham Young University (BYU) in Utah developed a <span class="hlt">sister</span> school program with teachers and children in Cuauhtemoc and Dublan (Mexico) to increase the culture vision of preservice teachers while simultaneously allowing elementary school children to develop culture awareness by participating in a cross-cultural learning…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=pierce&pg=6&id=EJ605384','ERIC'); return false;" href="http://eric.ed.gov/?q=pierce&pg=6&id=EJ605384"><span>Prejudice and Educational Choice: 75th Anniversary of Pierce v. Society of <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mizia, Robert Louis</p> <p>2000-01-01</p> <p>Recounts the landmark case of Pierce v. Society of <span class="hlt">Sisters</span>. Reminds readers that parental choice of an appropriate education for their children is a constitutional right and liberty under law and must be sustained. Asserts that true choice will occur only when consensus on public funding issues of school choice (including private and Catholic…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575"><span>Super-resolution kinetochore tracking reveals the mechanisms of human <span class="hlt">sister</span> kinetochore directional switching</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Burroughs, Nigel J; Harry, Edward F; McAinsh, Andrew D</p> <p>2015-01-01</p> <p>The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated <span class="hlt">sister</span> kinetochores. <span class="hlt">Sister</span> kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin. A crucial question is to understand how <span class="hlt">sister</span> kinetochores are coordinated to generate motility and directional switches. Here, we combine super-resolution tracking of kinetochores with automated switching-point detection to analyse <span class="hlt">sister</span> switching dynamics over thousands of events. We discover that switching is initiated by both the leading (microtubules depolymerising) or trailing (microtubules polymerising) kinetochore. Surprisingly, trail-driven switching generates an overstretch of the chromatin that relaxes over the following half-period. This rules out the involvement of a tension sensor, the central premise of the long-standing tension-model. Instead, our data support a model in which clocks set the intrinsic-switching time of the two kinetochore-attached microtubule fibres, with the centromeric spring tension operating as a feedback to slow or accelerate the clocks. DOI: http://dx.doi.org/10.7554/eLife.09500.001 PMID:26460545</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4728446','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4728446"><span>Overlap microtubules link <span class="hlt">sister</span> k-fibres and balance the forces on bi-oriented kinetochores</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M.</p> <p>2016-01-01</p> <p>During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between <span class="hlt">sister</span> kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term ‘bridging fibre', bridges <span class="hlt">sister</span> k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking <span class="hlt">sister</span> k-fibres, withstands the tension between <span class="hlt">sister</span> kinetochores and enables the spindle to obtain a curved shape. PMID:26728792</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=258716','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=258716"><span>A <span class="hlt">sister</span> group metabolomic contrast delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Understanding how plant cells tolerate dehydration is a vital prerequisite for developing strategies for improving drought tolerance. The desiccation tolerant grass Sporobolus stapfianus and the desiccation sensitive S. pyramidalis were used to form a <span class="hlt">sister</span>-group contrast to reveal adaptive metabo...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=marquez&pg=6&id=EJ903417','ERIC'); return false;" href="http://eric.ed.gov/?q=marquez&pg=6&id=EJ903417"><span>Transitioning from Doctoral Study to the Academy: Theorizing "Trenzas" of Identity for Latina <span class="hlt">Sister</span> Scholars</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Espino, Michelle M.; Munoz, Susana M.; Kiyama, Judy Marquez</p> <p>2010-01-01</p> <p>This article focuses on multiple truths pertaining to doctoral education as expressed by three Latina doctoral recipients. These scholars successfully navigated various educational processes with the support of one another, their families, faculty, and their chosen discipline. The authors, as <span class="hlt">sister</span> scholars, retell their educational journeys…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5343486','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5343486"><span>Management of E. coli <span class="hlt">sister</span> chromatid cohesion in response to genotoxic stress</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Vickridge, Elise; Planchenault, Charlene; Cockram, Charlotte; Junceda, Isabel Garcia; Espéli, Olivier</p> <p>2017-01-01</p> <p>Aberrant DNA replication is a major source of the mutations and chromosomal rearrangements associated with pathological disorders. In bacteria, several different DNA lesions are repaired by homologous recombination, a process that involves <span class="hlt">sister</span> chromatid pairing. Previous work in Escherichia coli has demonstrated that <span class="hlt">sister</span> chromatid interactions (SCIs) mediated by topological links termed precatenanes, are controlled by topoisomerase IV. In the present work, we demonstrate that during the repair of mitomycin C-induced lesions, topological links are rapidly substituted by an SOS-induced <span class="hlt">sister</span> chromatid cohesion process involving the RecN protein. The loss of SCIs and viability defects observed in the absence of RecN were compensated by alterations in topoisomerase IV, suggesting that the main role of RecN during DNA repair is to promote contacts between <span class="hlt">sister</span> chromatids. RecN also modulates whole chromosome organization and RecA dynamics suggesting that SCIs significantly contribute to the repair of DNA double-strand breaks (DSBs). PMID:28262707</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25902535','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25902535"><span>Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Whelan, Nathan V; Kocot, Kevin M; Moroz, Leonid L; Halanych, Kenneth M</p> <p>2015-05-05</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356"><span>Spotlights on our <span class="hlt">sister</span> journals: ChemistryOpen 1/2014</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>On these pages, we feature a selection of the excellent work that has recently been published in our <span class="hlt">sister</span> journals. If you are reading these pages on a computer, click on any of the items to read the full article. Otherwise please see the DOIs for easy online access through Wiley Online Library. PMID:24688888</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=learning+AND+shapes&pg=5&id=EJ997719','ERIC'); return false;" href="http://eric.ed.gov/?q=learning+AND+shapes&pg=5&id=EJ997719"><span>A Tale of Three <span class="hlt">Sisters</span>: Language Ideologies, Identities, and Negotiations in a Bilingual, Transnational Family</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Kendall A.</p> <p>2013-01-01</p> <p>This longitudinal case study investigated how linguistic identity was constructed, constrained, and performed by three <span class="hlt">sisters</span>, aged 1, 12, and 17, within one bilingual, transnational Ecuadorian-U.S. family. Data were collected over 14 months through weekly home visits that included participant observation, informal interviews, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED452094.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED452094.pdf"><span><span class="hlt">Sisters</span> in Science: Using Sports as a Vehicle for Science Learning.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.; Richardson, Greer M.; Green, Tina Sloan; Livingston, Beverly</p> <p></p> <p>This paper describes a project for upper elementary and middle school minority girl students called the <span class="hlt">Sisters</span> in Sport Science (SISS). The SISS program addresses the needs of urban girls in gaining access to equal education in science and mathematics by using athletics as a vehicle for learning. The program provides a non-competitive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=video+AND+games+AND+memory&pg=3&id=ED266892','ERIC'); return false;" href="http://eric.ed.gov/?q=video+AND+games+AND+memory&pg=3&id=ED266892"><span>Walking with Grandfather and Great Wolf and Little Mouse <span class="hlt">Sister</span>. Teacher's Guide.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lethbridge Univ. (Alberta).</p> <p></p> <p>Written for use with videotaped versions of the stories "Walking with Grandfather" and "Great Wolf and Little Mouse <span class="hlt">Sister</span>," this guide presents 20 lessons that teachers can adapt for students of various ages and use in integrated units or other curriculum approaches. The introductory material describes the use and philosophy of the video stories,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Women%27s+AND+Movement&pg=6&id=EJ1078896','ERIC'); return false;" href="http://eric.ed.gov/?q=Women%27s+AND+Movement&pg=6&id=EJ1078896"><span>Teaching <span class="hlt">Sisters</span> and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Raftery, Deirdre</p> <p>2015-01-01</p> <p>This article examines the management of the education enterprise of teaching <span class="hlt">Sisters</span>, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=origin+AND+philosophy&pg=4&id=EJ1003992','ERIC'); return false;" href="http://eric.ed.gov/?q=origin+AND+philosophy&pg=4&id=EJ1003992"><span>Empirical Psycho-Aesthetics and Her <span class="hlt">Sisters</span>: Substantive and Methodological Issues--Part II</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Konecni, Vladimir J.</p> <p>2013-01-01</p> <p>Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "<span class="hlt">sister</span>" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=World+AND+System&pg=4&id=EJ1048143','ERIC'); return false;" href="http://eric.ed.gov/?q=World+AND+System&pg=4&id=EJ1048143"><span>They Came with a Purpose: Educational Journeys of Nineteenth-Century Irish Dominican <span class="hlt">Sister</span> Teachers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Collins, Jenny</p> <p>2015-01-01</p> <p>Irish Catholic teaching <span class="hlt">sisters</span> were major actors in the development of education systems in New World countries such as the United States, Canada, South Africa, Australia and New Zealand. Immigrants themselves, they faced a number of key challenges as they sought to adapt Old World cultural and educational ideas to the education of the immigrant…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=teenage+AND+pregnancy&pg=5&id=EJ965819','ERIC'); return false;" href="http://eric.ed.gov/?q=teenage+AND+pregnancy&pg=5&id=EJ965819"><span>Youths' Caretaking of Their Adolescent <span class="hlt">Sisters</span>' Children: Its Costs and Benefits for Youths' Development</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>East, Patricia L.; Weisner, Thomas S.; Reyes, Barbara T.</p> <p>2006-01-01</p> <p>This study examined how time spent caring for a teenage <span class="hlt">sister</span>'s child and experiences in providing care related to youths' young adult outcomes. Latino and African American youths (N = 108) were studied during middle and late adolescence. Results indicated that youths who provided many hours of child care were more stressed and had lower school…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED440885.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED440885.pdf"><span>The <span class="hlt">Sisters</span> in Science Program: Building Girls' Interest and Achievement in Science and Mathematics.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.; Richardson, Greer M.; Livingston, Beverly</p> <p></p> <p>The <span class="hlt">Sisters</span> in Science program seeks to increase elementary school girls' interest and achievement in science and mathematics, to create a more positive learning climate for minority school girls and their families on academic and community/social levels, and increase the knowledge base and understanding of parents with respect to their influence…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27801743','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27801743"><span>99mTc-DMSA Uptake in a <span class="hlt">Sister</span> Mary Joseph's Nodule From Ovarian Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed</p> <p>2016-12-01</p> <p>A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic <span class="hlt">Sister</span> Mary Joseph's nodule seen on CT performed a week earlier.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol17/pdf/CFR-2012-title40-vol17-sec79-65.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol17/pdf/CFR-2012-title40-vol17-sec79-65.pdf"><span>40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups of... is considered not to induce rearrangements of DNA segments in this system. (iii) Both biological...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol17/pdf/CFR-2013-title40-vol17-sec79-65.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol17/pdf/CFR-2013-title40-vol17-sec79-65.pdf"><span>40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-07-01</p> <p>...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups of... is considered not to induce rearrangements of DNA segments in this system. (iii) Both biological...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12959806','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12959806"><span><span class="hlt">Big</span> <span class="hlt">brother</span> is watching you--the ethical implications of electronic surveillance measures in the elderly with dementia and in adults with learning difficulties.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Welsh, S; Hassiotis, A; O'Mahoney, G; Deahl, M</p> <p>2003-09-01</p> <p>Electronic surveillance has insidiously seeped into the fabric of society with little public debate about its moral implications. Perceived by some as a sinister Orwellian tool of repression and social control, the new technologies offer comfort and security to others; a benevolent parental watchful eye. Nervousness at being watched has been replaced increasingly by nervousness if we're not. These technologies are now becoming widely available to health care professionals who have had little opportunity to consider their ethical and moral ramifications. Electronic tagging and tracking devices may be seen as away of creating a more secure environment for vulnerable individuals such as the elderly with dementia or people with learning disabilities. However, the proponents of surveillance devices have met with considerable resistance and opposition,from those who perceive it as contrary to human dignity and freedom, with its connotations of criminal surveillance. In addition, they cite increased opportunity for abuse through, for example, the withdrawal of staff and financial resources from the care of people with complex needs. Implementing these technologies, therefore, has ethical implications for human rights and civil liberties. Optional alternatives to long-term and/or restrictive care, in the context of the practical difficulties involved in caring for those who represent a risk to themselves from wandering, demands rigorous exploration of pragmatic questions of morality, with reference to risk versus benefit strategies. Like reproductive cloning techniques, the mere existence of surveillance technologies is morally neutral. Rather it is the use (in this instance that of health and social care settings) to which it is put which has the potential for good or bad.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5291030','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5291030"><span>Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase <span class="hlt">BIG</span> <span class="hlt">BROTHER</span> in Controlling Leaf Growth and Development1[OPEN</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Vanhaeren, Hannes; De Milde, Liesbeth</p> <p>2017-01-01</p> <p>The final size of plant organs is determined by a combination of cell proliferation and cell expansion. Leaves account for a large part of above-ground biomass and provide energy to complete the plant’s life cycle. Although the final size of leaves is remarkably constant under fixed environmental conditions, several genes have been described to enhance leaf growth when their expression is modulated. In Arabidopsis (Arabidopsis thaliana), mutations in DA1 and BB increase leaf size, an effect that is synergistically enhanced in the double mutant. Here, we show that overexpression of a dominant-negative version of DA1 enhances leaf size in a broad range of natural accessions of this species, indicating a highly conserved role of this protein in controlling organ size. We also found that during early stages of development, leaves of da1-1 and bb/eod1-2 mutants were already larger than the isogenic Col-0 wild type, but this phenotype was triggered by different cellular mechanisms. Later during development, da1-1 and bb/eod1-2 leaves showed a prolonged longevity, which was enhanced in the double mutant. Conversely, ectopic expression of DA1 or BB restricted growth and promoted leaf senescence. In concert, shortly upon induction of DA1 and BB expression, several marker genes for the transition from proliferation to expansion were highly up-regulated. Additionally, multiple genes involved in maintaining the mitotic cell cycle were rapidly down-regulated and senescence genes were strongly up-regulated, particularly upon BB induction. With these results, we demonstrate that DA1 and BB restrict leaf size and promote senescence through converging and different mechanisms. PMID:28003326</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016E%26ES...46a2058L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016E%26ES...46a2058L"><span>Considerations on Geospatial <span class="hlt">Big</span> Data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>LIU, Zhen; GUO, Huadong; WANG, Changlin</p> <p>2016-11-01</p> <p>Geospatial data, as a significant portion of <span class="hlt">big</span> data, has recently gained the full attention of researchers. However, few researchers focus on the evolution of geospatial data and its scientific research methodologies. When entering into the <span class="hlt">big</span> data era, fully understanding the changing research paradigm associated with geospatial data will definitely benefit future research on <span class="hlt">big</span> data. In this paper, we look deep into these issues by examining the components and features of geospatial <span class="hlt">big</span> data, reviewing relevant scientific research methodologies, and examining the evolving pattern of geospatial data in the scope of the four ‘science paradigms’. This paper proposes that geospatial <span class="hlt">big</span> data has significantly shifted the scientific research methodology from ‘hypothesis to data’ to ‘data to questions’ and it is important to explore the generality of growing geospatial data ‘from bottom to top’. Particularly, four research areas that mostly reflect data-driven geospatial research are proposed: spatial correlation, spatial analytics, spatial visualization, and scientific knowledge discovery. It is also pointed out that privacy and quality issues of geospatial data may require more attention in the future. Also, some challenges and thoughts are raised for future discussion.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27068058','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27068058"><span><span class="hlt">Big</span> data for bipolar disorder.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Monteith, Scott; Glenn, Tasha; Geddes, John; Whybrow, Peter C; Bauer, Michael</p> <p>2016-12-01</p> <p>The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are <span class="hlt">big</span> data and advances in the ability to analyze these data. The impact of <span class="hlt">big</span> data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of <span class="hlt">big</span> data today are electronic medical records (EMR), claims, and registry data from providers and payers. In the near future, data created by patients from active monitoring, passive monitoring of Internet and smartphone activities, and from sensors may be integrated with the EMR. Diverse data sources from outside of medicine, such as government financial data, will be linked for research. Over the long term, genetic and imaging data will be integrated with the EMR, and there will be more emphasis on predictive models. Many technical challenges remain when analyzing <span class="hlt">big</span> data that relates to size, heterogeneity, complexity, and unstructured text data in the EMR. Human judgement and subject matter expertise are critical parts of <span class="hlt">big</span> data analysis, and the active participation of psychiatrists is needed throughout the analytical process.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFMIN14B..03N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFMIN14B..03N"><span>GEOSS: Addressing <span class="hlt">Big</span> Data Challenges</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nativi, S.; Craglia, M.; Ochiai, O.</p> <p>2014-12-01</p> <p>In the sector of Earth Observation, the explosion of data is due to many factors including: new satellite constellations, the increased capabilities of sensor technologies, social media, crowdsourcing, and the need for multidisciplinary and collaborative research to face Global Changes. In this area, there are many expectations and concerns about <span class="hlt">Big</span> Data. Vendors have attempted to use this term for their commercial purposes. It is necessary to understand whether <span class="hlt">Big</span> Data is a radical shift or an incremental change for the existing digital infrastructures. This presentation tries to explore and discuss the impact of <span class="hlt">Big</span> Data challenges and new capabilities on the Global Earth Observation System of Systems (GEOSS) and particularly on its common digital infrastructure called GCI. GEOSS is a global and flexible network of content providers allowing decision makers to access an extraordinary range of data and information at their desk. The impact of the <span class="hlt">Big</span> Data dimensionalities (commonly known as 'V' axes: volume, variety, velocity, veracity, visualization) on GEOSS is discussed. The main solutions and experimentation developed by GEOSS along these axes are introduced and analyzed. GEOSS is a pioneering framework for global and multidisciplinary data sharing in the Earth Observation realm; its experience on <span class="hlt">Big</span> Data is valuable for the many lessons learned.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26077871','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26077871"><span>[<span class="hlt">Big</span> data in official statistics].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zwick, Markus</p> <p>2015-08-01</p> <p>The concept of "<span class="hlt">big</span> data" stands to change the face of official statistics over the coming years, having an impact on almost all aspects of data production. The tasks of future statisticians will not necessarily be to produce new data, but rather to identify and make use of existing data to adequately describe social and economic phenomena. Until <span class="hlt">big</span> data can be used correctly in official statistics, a lot of questions need to be answered and problems solved: the quality of data, data protection, privacy, and the sustainable availability are some of the more pressing issues to be addressed. The essential skills of official statisticians will undoubtedly change, and this implies a number of challenges to be faced by statistical education systems, in universities, and inside the statistical offices. The national statistical offices of the European Union have concluded a concrete strategy for exploring the possibilities of <span class="hlt">big</span> data for official statistics, by means of the <span class="hlt">Big</span> Data Roadmap and Action Plan 1.0. This is an important first step and will have a significant influence on implementing the concept of <span class="hlt">big</span> data inside the statistical offices of Germany.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16080001','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16080001"><span>Mutant analysis, protein-protein interactions and subcellular localization of the Arabidopsis B <span class="hlt">sister</span> (ABS) protein.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kaufmann, Kerstin; Anfang, Nicole; Saedler, Heinz; Theissen, Günter</p> <p>2005-09-01</p> <p>Recently, close relatives of class B floral homeotic genes, termed B(<span class="hlt">sister</span>) genes, have been identified in both angiosperms and gymnosperms. In contrast to the B genes themselves, B(<span class="hlt">sister</span>) genes are exclusively expressed in female reproductive organs, especially in the envelopes or integuments surrounding the ovules. This suggests an important ancient function in ovule or seed development for B(<span class="hlt">sister</span>) genes, which has been conserved for about 300 million years. However, investigation of the first loss-of-function mutant for a B(<span class="hlt">sister</span>) gene (ABS/TT16 from Arabidopsis) revealed only a weak phenotype affecting endothelium formation. Here, we present an analysis of two additional mutant alleles, which corroborates this weak phenotype. Transgenic plants that ectopically express ABS show changes in the growth and identity of floral organs, suggesting that ABS can interact with floral homeotic proteins. Yeast-two-hybrid and three-hybrid analyses indicated that ABS can form dimers with SEPALLATA (SEP) floral homeotic proteins and multimeric complexes that also include the AGAMOUS-like proteins SEEDSTICK (STK) or SHATTERPROOF1/2 (SHP1, SHP2). These data suggest that the formation of multimeric transcription factor complexes might be a general phenomenon among MIKC-type MADS-domain proteins in angiosperms. Heterodimerization of ABS with SEP3 was confirmed by gel retardation assays. Fusion proteins tagged with CFP (Cyan Fluorescent Protein) and YFP (Yellow Fluorescent Protein) in Arabidopsis protoplasts showed that ABS is localized in the nucleus. Phylogenetic analysis revealed the presence of a structurally deviant, but closely related, paralogue of ABS in the Arabidopsis genome. Thus the evolutionary developmental genetics of B(<span class="hlt">sister</span>) genes can probably only be understood as part of a complex and redundant gene network that may govern ovule formation in a conserved manner, which has yet to be fully explored.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/1325454','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/1325454"><span>Experimental Test Plan for PWR <span class="hlt">Sister</span> Rods in the High Burnup Spent Fuel Data Project</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Montgomery, Rose; Scaglione, John M; Bevard, Bruce Balkcom; Hanson, Brady; Billone, Dr. Michael</p> <p>2016-01-01</p> <p>The High Burnup Spent Fuel Data project pulled 25 <span class="hlt">sister</span> rods (9 from the project assemblies and 16 from similar HBU assemblies) for characterization. The 25 <span class="hlt">sister</span> rods are all high burnup and cover the range of modern domestic cladding alloys. The 25 <span class="hlt">sister</span> rods were shipped to Oak Ridge National Laboratory (ORNL) in early 2016 for detailed non-destructive and destructive examination. Examinations are intended to provide baseline data on the initial physical state of the cladding and fuel prior to the loading, drying, and long-term dry storage process. Further examinations are focused on determining the effects of temperatures encountered during and following drying. Similar tests will be performed on rods taken from the project assemblies at the end of their long-term storage in a TN-32 dry storage cask (the cask rods ) to identify any significant changes in the fuel rods that may have occurred during the dry storage period. Additionally, some of the <span class="hlt">sister</span> rods will be used for separate effects testing to expand the applicability of the project data to the fleet, and to address some of the data-related gaps associated with extended storage and subsequent transportation of high burnup fuel. A draft test plan is being developed that describes the experimental work to be conducted on the <span class="hlt">sister</span> rods. This paper summarizes the draft test plan and necessary coordination activities for the multi-year experimental program to supply data relevant to the assessment of the safety of long-term storage followed by transportation of high burnup spent fuel.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19920329','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19920329"><span>Legal consequences for torture in children cases: the Gomez Paquiyauri <span class="hlt">Brothers</span> vs Peru case.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tinta, Monica Feria</p> <p>2009-01-01</p> <p>The Gomez Paquiyauri <span class="hlt">Brothers</span> case, before the Inter-American Court of Human Rights, was the first international case concerning the protection of children in the context of armed conflict where an international court stated the law concerning the duties of States towards children even in the context of war, and provided for reparations. As such it represents a landmark decision. The case arose from the illegal detention, torture and extrajudicial execution of two minors, Emilio and Rafael Gomez Paquiyauri, at the hands of Peruvian Police in 1991, under the Fujimori Administration at a time when the internal war in Peru was at its peak. Unlike most cases coming to the jurisdiction of the Inter-American Court, the case had been subject to domestic criminal investigations that had led to the convictions of two low ranking policemen. Yet a more subtle pattern of impunity lied at the root of the case. Torture had been denied by the State, and the prosecutions of low ranking policemen had intended to cover up the responsibility of those who ordered a policy of torture and executions (including the existence of secret codes for the torture and elimination of suspects of "terrorism") during the years of the internal armed conflict in Peru. The joint work of legal and medical expertise in the litigation of the case permitted the establishment of the facts and the law, obtaining an award of 740,500 dollars for the victims and a number of measures of reparation including guarantees of non-repetition and satisfaction, such as the naming of a school after the victims.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26229957','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26229957"><span><span class="hlt">Big</span> Data Analytics in Healthcare.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Belle, Ashwin; Thiagarajan, Raghuram; Soroushmehr, S M Reza; Navidi, Fatemeh; Beard, Daniel A; Najarian, Kayvan</p> <p>2015-01-01</p> <p>The rapidly expanding field of <span class="hlt">big</span> data analytics has started to play a pivotal role in the evolution of healthcare practices and research. It has provided tools to accumulate, manage, analyze, and assimilate large volumes of disparate, structured, and unstructured data produced by current healthcare systems. <span class="hlt">Big</span> data analytics has been recently applied towards aiding the process of care delivery and disease exploration. However, the adoption rate and research development in this space is still hindered by some fundamental problems inherent within the <span class="hlt">big</span> data paradigm. In this paper, we discuss some of these major challenges with a focus on three upcoming and promising areas of medical research: image, signal, and genomics based analytics. Recent research which targets utilization of large volumes of medical data while combining multimodal data from disparate sources is discussed. Potential areas of research within this field which have the ability to provide meaningful impact on healthcare delivery are also examined.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503556','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503556"><span><span class="hlt">Big</span> Data Analytics in Healthcare</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Belle, Ashwin; Thiagarajan, Raghuram; Soroushmehr, S. M. Reza; Navidi, Fatemeh; Beard, Daniel A.; Najarian, Kayvan</p> <p>2015-01-01</p> <p>The rapidly expanding field of <span class="hlt">big</span> data analytics has started to play a pivotal role in the evolution of healthcare practices and research. It has provided tools to accumulate, manage, analyze, and assimilate large volumes of disparate, structured, and unstructured data produced by current healthcare systems. <span class="hlt">Big</span> data analytics has been recently applied towards aiding the process of care delivery and disease exploration. However, the adoption rate and research development in this space is still hindered by some fundamental problems inherent within the <span class="hlt">big</span> data paradigm. In this paper, we discuss some of these major challenges with a focus on three upcoming and promising areas of medical research: image, signal, and genomics based analytics. Recent research which targets utilization of large volumes of medical data while combining multimodal data from disparate sources is discussed. Potential areas of research within this field which have the ability to provide meaningful impact on healthcare delivery are also examined. PMID:26229957</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26151137','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26151137"><span><span class="hlt">Big</span> Data: Astronomical or Genomical?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stephens, Zachary D; Lee, Skylar Y; Faghri, Faraz; Campbell, Roy H; Zhai, Chengxiang; Efron, Miles J; Iyer, Ravishankar; Schatz, Michael C; Sinha, Saurabh; Robinson, Gene E</p> <p>2015-07-01</p> <p>Genomics is a <span class="hlt">Big</span> Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other <span class="hlt">Big</span> Data domains. Projecting to the year 2025, we compared genomics with three other major generators of <span class="hlt">Big</span> Data: astronomy, YouTube, and Twitter. Our estimates show that genomics is a "four-headed beast"--it is either on par with or the most demanding of the domains analyzed here in terms of data acquisition, storage, distribution, and analysis. We discuss aspects of new technologies that will need to be developed to rise up and meet the computational challenges that genomics poses for the near future. Now is the time for concerted, community-wide planning for the "genomical" challenges of the next decade.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ARep...60..857M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ARep...60..857M"><span>Multiwavelength astronomy and <span class="hlt">big</span> data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mickaelian, A. M.</p> <p>2016-09-01</p> <p>Two major characteristics of modern astronomy are multiwavelength (MW) studies (fromγ-ray to radio) and <span class="hlt">big</span> data (data acquisition, storage and analysis). Present astronomical databases and archives contain billions of objects observed at various wavelengths, both galactic and extragalactic, and the vast amount of data on them allows new studies and discoveries. Astronomers deal with <span class="hlt">big</span> numbers. Surveys are the main source for discovery of astronomical objects and accumulation of observational data for further analysis, interpretation, and achieving scientific results. We review the main characteristics of astronomical surveys, compare photographic and digital eras of astronomical studies (including the development of wide-field observations), describe the present state of MW surveys, and discuss the <span class="hlt">Big</span> Data in astronomy and related topics of Virtual Observatories and Computational Astrophysics. The review includes many numbers and data that can be compared to have a possibly overall understanding on the Universe, cosmic numbers and their relationship to modern computational facilities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4494865','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4494865"><span><span class="hlt">Big</span> Data: Astronomical or Genomical?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Stephens, Zachary D.; Lee, Skylar Y.; Faghri, Faraz; Campbell, Roy H.; Zhai, Chengxiang; Efron, Miles J.; Iyer, Ravishankar; Schatz, Michael C.; Sinha, Saurabh; Robinson, Gene E.</p> <p>2015-01-01</p> <p>Genomics is a <span class="hlt">Big</span> Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other <span class="hlt">Big</span> Data domains. Projecting to the year 2025, we compared genomics with three other major generators of <span class="hlt">Big</span> Data: astronomy, YouTube, and Twitter. Our estimates show that genomics is a “four-headed beast”—it is either on par with or the most demanding of the domains analyzed here in terms of data acquisition, storage, distribution, and analysis. We discuss aspects of new technologies that will need to be developed to rise up and meet the computational challenges that genomics poses for the near future. Now is the time for concerted, community-wide planning for the “genomical” challenges of the next decade. PMID:26151137</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title38-vol1/pdf/CFR-2013-title38-vol1-sec12-9.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title38-vol1/pdf/CFR-2013-title38-vol1-sec12-9.pdf"><span>38 CFR 12.9 - Rights of designate; sales instruction; transportation charges.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-07-01</p> <p>... executor or administrator, widow, child, grandchild, mother, father, grandmother, grandfather, <span class="hlt">brother</span>, or... widower), child, grandchild, mother, father, grandmother, grandfather, <span class="hlt">brother</span> and <span class="hlt">sister</span>, if known....</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title38-vol1/pdf/CFR-2014-title38-vol1-sec12-9.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title38-vol1/pdf/CFR-2014-title38-vol1-sec12-9.pdf"><span>38 CFR 12.9 - Rights of designate; sales instruction; transportation charges.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... executor or administrator, widow, child, grandchild, mother, father, grandmother, grandfather, <span class="hlt">brother</span>, or... widower), child, grandchild, mother, father, grandmother, grandfather, <span class="hlt">brother</span> and <span class="hlt">sister</span>, if known....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26614539','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26614539"><span>[<span class="hlt">Big</span> Data- challenges and risks].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krauß, Manuela; Tóth, Tamás; Hanika, Heinrich; Kozlovszky, Miklós; Dinya, Elek</p> <p>2015-12-06</p> <p>The term "<span class="hlt">Big</span> Data" is commonly used to describe the growing mass of information being created recently. New conclusions can be drawn and new services can be developed by the connection, processing and analysis of these information. This affects all aspects of life, including health and medicine. The authors review the application areas of <span class="hlt">Big</span> Data, and present examples from health and other areas. However, there are several preconditions of the effective use of the opportunities: proper infrastructure, well defined regulatory environment with particular emphasis on data protection and privacy. These issues and the current actions for solution are also presented.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17230486','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17230486"><span>Severe hypertelorism, midface prominence, prominent/simple ears, severe myopia, borderline intelligence, and bone fragility in two <span class="hlt">brothers</span>: new syndrome?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hamamy, Hanan A; Teebi, Ahmad S; Oudjhane, Kamaldine; Shegem, N N; Ajlouni, K M</p> <p>2007-02-01</p> <p>We report on two <span class="hlt">brothers</span>, born to double first cousin Jordanian Arab parents, with a syndrome comprising severe hypertelorism with upslanted palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Both have severe myopia, mild to moderate sensori-neural hearing loss and borderline intelligence. Results of chromosome analysis were normal as was a FISH assay for subtelomeric rearrangements. The father has mild hypertelorism but the family history is otherwise unremarkable. We think that this represents a previously unrecognized autosomal or X-linked recessive syndrome.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4886912','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4886912"><span>Familial vasculitides: granulomatosis with polyangitis and microscopic polyangitis in two <span class="hlt">brothers</span> with differing anti-neutrophil cytoplasm antibody specificity</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Prendecki, Maria; Cairns, Tom; Pusey, Charles D.</p> <p>2016-01-01</p> <p>Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a group of rare autoimmune diseases. Although the aetiology of AAV is uncertain, it is likely that genetic and environmental factors contribute. We report the unusual case of two <span class="hlt">brothers</span> presenting with AAV with differing clinical pictures and differing ANCA specificity. There is a recently identified difference in genetic risk factors associated with ANCA specificity, making it surprising that first-degree relatives develop AAV with differing clinical and serological features. Our report illustrates the complex aetiology of AAV and suggests that further research on the interaction of genetic and environmental factors is needed. PMID:27274829</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016NatSR...633740P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016NatSR...633740P"><span>True Randomness from <span class="hlt">Big</span> Data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Papakonstantinou, Periklis A.; Woodruff, David P.; Yang, Guang</p> <p>2016-09-01</p> <p>Generating random bits is a difficult task, which is important for physical systems simulation, cryptography, and many applications that rely on high-quality random bits. Our contribution is to show how to generate provably random bits from uncertain events whose outcomes are routinely recorded in the form of massive data sets. These include scientific data sets, such as in astronomics, genomics, as well as data produced by individuals, such as internet search logs, sensor networks, and social network feeds. We view the generation of such data as the sampling process from a <span class="hlt">big</span> source, which is a random variable of size at least a few gigabytes. Our view initiates the study of <span class="hlt">big</span> sources in the randomness extraction literature. Previous approaches for <span class="hlt">big</span> sources rely on statistical assumptions about the samples. We introduce a general method that provably extracts almost-uniform random bits from <span class="hlt">big</span> sources and extensively validate it empirically on real data sets. The experimental findings indicate that our method is efficient enough to handle large enough sources, while previous extractor constructions are not efficient enough to be practical. Quality-wise, our method at least matches quantum randomness expanders and classical world empirical extractors as measured by standardized tests.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=big+AND+space&pg=6&id=EJ783446','ERIC'); return false;" href="http://eric.ed.gov/?q=big+AND+space&pg=6&id=EJ783446"><span><span class="hlt">Big</span> Opportunities in Small Science</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Dewey, T. Gregory</p> <p>2007-01-01</p> <p>A transformation is occurring that will have a major impact on how academic science is done and how scientists are trained. That transformation--driven by declining federal funds, as well as by the rising cost of technology and the need for costly, labor-intensive interdisciplinary approaches--is from small science to <span class="hlt">big</span> science. It is…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Tooley&pg=2&id=EJ726234','ERIC'); return false;" href="http://eric.ed.gov/?q=Tooley&pg=2&id=EJ726234"><span><span class="hlt">Big</span>6 Turbotools and Synthesis</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tooley, Melinda</p> <p>2005-01-01</p> <p>The different tools that are helpful during the Synthesis stage, their role in boosting students abilities in Synthesis and the way in which it can be customized to meet the needs of each group of students are discussed. <span class="hlt">Big</span>6 TurboTools offers several tools to help complete the task. In Synthesis stage, these same tools along with Turbo Report and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/1167036','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/1167036"><span><span class="hlt">Big</span> Explosives Experimental Facility - BEEF</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>2014-10-31</p> <p>The <span class="hlt">Big</span> Explosives Experimental Facility or BEEF is a ten acre fenced high explosive testing facility that provides data to support stockpile stewardship and other national security programs. At BEEF conventional high explosives experiments are safely conducted providing sophisticated diagnostics such as high speed optics and x-ray radiography.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/sciencecinema/biblio/1167036','SCIGOVIMAGE-SCICINEMA'); return false;" href="http://www.osti.gov/sciencecinema/biblio/1167036"><span><span class="hlt">Big</span> Explosives Experimental Facility - BEEF</span></a></p> <p><a target="_blank" href="http://www.osti.gov/sciencecinema/">ScienceCinema</a></p> <p>None</p> <p>2016-07-12</p> <p>The <span class="hlt">Big</span> Explosives Experimental Facility or BEEF is a ten acre fenced high explosive testing facility that provides data to support stockpile stewardship and other national security programs. At BEEF conventional high explosives experiments are safely conducted providing sophisticated diagnostics such as high speed optics and x-ray radiography.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3827930','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3827930"><span>Chinchilla "<span class="hlt">big</span>" and "little" gastrins.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shinomura, Y; Eng, J; Yalow, R S</p> <p>1987-02-27</p> <p>Gastrin heptadecapeptides (gastrins I and II which differ in the presence of sulfate on the tyrosine of the latter) have been purified and sequenced from several mammalian species including pig, dog, cat, sheep, cow, human and rat. A 34 amino acid precursor ("<span class="hlt">big</span>" gastrin), generally accounting for only 5% of total gastrin immunoreactivity, has been purified and sequenced only from the pig, human, dog and goat. Recently we have demonstrated that guinea pig (GP) "little" gastrin is a hexadecapeptide due to a deletion of a glutamic acid in the region 6-9 from its NH2-terminus and that GP "<span class="hlt">big</span>" gastrin is a 33 amino acid peptide. The chinchilla, like the GP, is a New World hystricomorph. This report describes the extraction and purification of "little" and "<span class="hlt">big</span>" gastrins from 31 chinchilla antra. Chinchilla "little" gastrin is a hexadecapeptide with a sequence identical to that of the GP and its "<span class="hlt">big</span>" gastrin is a 33 amino acid peptide with the following sequence: (See text)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.usgs.gov/gip/2006/35/','USGSPUBS'); return false;" href="https://pubs.usgs.gov/gip/2006/35/"><span>1976 <span class="hlt">Big</span> Thompson flood, Colorado</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Jarrett, R. D.; Vandas, S.J.</p> <p>2006-01-01</p> <p>In the early evening of July 31, 1976, a large stationary thunderstorm released as much as 7.5 inches of rainfall in about an hour (about 12 inches in a few hours) in the upper reaches of the <span class="hlt">Big</span> Thompson River drainage. This large amount of rainfall in such a short period of time produced a flash flood that caught residents and tourists by surprise. The immense volume of water that churned down the narrow <span class="hlt">Big</span> Thompson Canyon scoured the river channel and destroyed everything in its path, including 418 homes, 52 businesses, numerous bridges, paved and unpaved roads, power and telephone lines, and many other structures. The tragedy claimed the lives of 144 people. Scores of other people narrowly escaped with their lives. The <span class="hlt">Big</span> Thompson flood ranks among the deadliest of Colorado's recorded floods. It is one of several destructive floods in the United States that has shown the necessity of conducting research to determine the causes and effects of floods. The U.S. Geological Survey (USGS) conducts research and operates a Nationwide streamgage network to help understand and predict the magnitude and likelihood of large streamflow events such as the <span class="hlt">Big</span> Thompson Flood. Such research and streamgage information are part of an ongoing USGS effort to reduce flood hazards and to increase public awareness.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=paleontology&pg=5&id=EJ442132','ERIC'); return false;" href="http://eric.ed.gov/?q=paleontology&pg=5&id=EJ442132"><span>The Case for "<span class="hlt">Big</span> History."</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Christian, David</p> <p>1991-01-01</p> <p>Urges an approach to the teaching of history that takes the largest possible perspective, crossing time as well as space. Discusses the problems and advantages of such an approach. Describes a course on "<span class="hlt">big</span>" history that begins with time, creation myths, and astronomy, and moves on to paleontology and evolution. (DK)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=universe&pg=3&id=EJ1008541','ERIC'); return false;" href="http://eric.ed.gov/?q=universe&pg=3&id=EJ1008541"><span>The International <span class="hlt">Big</span> History Association</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Duffy, Michael; Duffy, D'Neil</p> <p>2013-01-01</p> <p>IBHA, the International <span class="hlt">Big</span> History Association, was organized in 2010 and "promotes the unified, interdisciplinary study and teaching of history of the Cosmos, Earth, Life, and Humanity." This is the vision that Montessori embraced long before the discoveries of modern science fleshed out the story of the evolving universe. "Big…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ949549.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ949549.pdf"><span>China: <span class="hlt">Big</span> Changes Coming Soon</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rowen, Henry S.</p> <p>2011-01-01</p> <p><span class="hlt">Big</span> changes are ahead for China, probably abrupt ones. The economy has grown so rapidly for many years, over 30 years at an average of nine percent a year, that its size makes it a major player in trade and finance and increasingly in political and military matters. This growth is not only of great importance internationally, it is already having…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5036032','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5036032"><span>True Randomness from <span class="hlt">Big</span> Data</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Papakonstantinou, Periklis A.; Woodruff, David P.; Yang, Guang</p> <p>2016-01-01</p> <p>Generating random bits is a difficult task, which is important for physical systems simulation, cryptography, and many applications that rely on high-quality random bits. Our contribution is to show how to generate provably random bits from uncertain events whose outcomes are routinely recorded in the form of massive data sets. These include scientific data sets, such as in astronomics, genomics, as well as data produced by individuals, such as internet search logs, sensor networks, and social network feeds. We view the generation of such data as the sampling process from a <span class="hlt">big</span> source, which is a random variable of size at least a few gigabytes. Our view initiates the study of <span class="hlt">big</span> sources in the randomness extraction literature. Previous approaches for <span class="hlt">big</span> sources rely on statistical assumptions about the samples. We introduce a general method that provably extracts almost-uniform random bits from <span class="hlt">big</span> sources and extensively validate it empirically on real data sets. The experimental findings indicate that our method is efficient enough to handle large enough sources, while previous extractor constructions are not efficient enough to be practical. Quality-wise, our method at least matches quantum randomness expanders and classical world empirical extractors as measured by standardized tests. PMID:27666514</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27666514','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27666514"><span>True Randomness from <span class="hlt">Big</span> Data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Papakonstantinou, Periklis A; Woodruff, David P; Yang, Guang</p> <p>2016-09-26</p> <p>Generating random bits is a difficult task, which is important for physical systems simulation, cryptography, and many applications that rely on high-quality random bits. Our contribution is to show how to generate provably random bits from uncertain events whose outcomes are routinely recorded in the form of massive data sets. These include scientific data sets, such as in astronomics, genomics, as well as data produced by individuals, such as internet search logs, sensor networks, and social network feeds. We view the generation of such data as the sampling process from a <span class="hlt">big</span> source, which is a random variable of size at least a few gigabytes. Our view initiates the study of <span class="hlt">big</span> sources in the randomness extraction literature. Previous approaches for <span class="hlt">big</span> sources rely on statistical assumptions about the samples. We introduce a general method that provably extracts almost-uniform random bits from <span class="hlt">big</span> sources and extensively validate it empirically on real data sets. The experimental findings indicate that our method is efficient enough to handle large enough sources, while previous extractor constructions are not efficient enough to be practical. Quality-wise, our method at least matches quantum randomness expanders and classical world empirical extractors as measured by standardized tests.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1042664','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1042664"><span>The <span class="hlt">Big</span>Boss Experiment</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; Bebek, C.; Becerril, S.; Blanton, M.; Bolton, A.; Bromley, B.; Cahn, R.; Carton, P.-H.; Cervanted-Cota, J.L.; Chu, Y.; Cortes, M.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna / /IAC, Mexico / / /Madrid, IFT /Marseille, Lab. Astrophys. / / /New York U. /Valencia U.</p> <p>2012-06-07</p> <p><span class="hlt">Big</span>BOSS is a Stage IV ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of structure with a wide-area galaxy and quasar redshift survey over 14,000 square degrees. It has been conditionally accepted by NOAO in response to a call for major new instrumentation and a high-impact science program for the 4-m Mayall telescope at Kitt Peak. The <span class="hlt">Big</span>BOSS instrument is a robotically-actuated, fiber-fed spectrograph capable of taking 5000 simultaneous spectra over a wavelength range from 340 nm to 1060 nm, with a resolution R = {lambda}/{Delta}{lambda} = 3000-4800. Using data from imaging surveys that are already underway, spectroscopic targets are selected that trace the underlying dark matter distribution. In particular, targets include luminous red galaxies (LRGs) up to z = 1.0, extending the BOSS LRG survey in both redshift and survey area. To probe the universe out to even higher redshift, <span class="hlt">Big</span>BOSS will target bright [OII] emission line galaxies (ELGs) up to z = 1.7. In total, 20 million galaxy redshifts are obtained to measure the BAO feature, trace the matter power spectrum at smaller scales, and detect redshift space distortions. <span class="hlt">Big</span>BOSS will provide additional constraints on early dark energy and on the curvature of the universe by measuring the Ly-alpha forest in the spectra of over 600,000 2.2 < z < 3.5 quasars. <span class="hlt">Big</span>BOSS galaxy BAO measurements combined with an analysis of the broadband power, including the Ly-alpha forest in <span class="hlt">Big</span>BOSS quasar spectra, achieves a FOM of 395 with Planck plus Stage III priors. This FOM is based on conservative assumptions for the analysis of broad band power (k{sub max} = 0.15), and could grow to over 600 if current work allows us to push the analysis to higher wave numbers (k{sub max} = 0.3). <span class="hlt">Big</span>BOSS will also place constraints on theories of modified gravity and inflation, and will measure the sum of neutrino masses to 0.024 eV accuracy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=FAST&pg=5&id=EJ1104630','ERIC'); return false;" href="http://eric.ed.gov/?q=FAST&pg=5&id=EJ1104630"><span>A SWOT Analysis of <span class="hlt">Big</span> Data</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ahmadi, Mohammad; Dileepan, Parthasarati; Wheatley, Kathleen K.</p> <p>2016-01-01</p> <p>This is the decade of data analytics and <span class="hlt">big</span> data, but not everyone agrees with the definition of <span class="hlt">big</span> data. Some researchers see it as the future of data analysis, while others consider it as hype and foresee its demise in the near future. No matter how it is defined, <span class="hlt">big</span> data for the time being is having its glory moment. The most important…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27559194','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27559194"><span><span class="hlt">Big</span> Data: Implications for Health System Pharmacy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stokes, Laura B; Rogers, Joseph W; Hertig, John B; Weber, Robert J</p> <p>2016-07-01</p> <p><span class="hlt">Big</span> Data refers to datasets that are so large and complex that traditional methods and hardware for collecting, sharing, and analyzing them are not possible. <span class="hlt">Big</span> Data that is accurate leads to more confident decision making, improved operational efficiency, and reduced costs. The rapid growth of health care information results in <span class="hlt">Big</span> Data around health services, treatments, and outcomes, and <span class="hlt">Big</span> Data can be used to analyze the benefit of health system pharmacy services. The goal of this article is to provide a perspective on how <span class="hlt">Big</span> Data can be applied to health system pharmacy. It will define <span class="hlt">Big</span> Data, describe the impact of <span class="hlt">Big</span> Data on population health, review specific implications of <span class="hlt">Big</span> Data in health system pharmacy, and describe an approach for pharmacy leaders to effectively use <span class="hlt">Big</span> Data. A few strategies involved in managing <span class="hlt">Big</span> Data in health system pharmacy include identifying potential opportunities for <span class="hlt">Big</span> Data, prioritizing those opportunities, protecting privacy concerns, promoting data transparency, and communicating outcomes. As health care information expands in its content and becomes more integrated, <span class="hlt">Big</span> Data can enhance the development of patient-centered pharmacy services.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=337359','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=337359"><span><span class="hlt">Big</span> sagebrush seed bank densities following wildfires</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p><span class="hlt">Big</span> sagebrush (Artemisia spp.) is a critical shrub to many wildlife species including sage grouse (Centrocercus urophasianus), mule deer (Odocoileus hemionus), and pygmy rabbit (Brachylagus idahoensis). <span class="hlt">Big</span> sagebrush is killed by wildfires and <span class="hlt">big</span> sagebrush seed is generally short-lived and do not s...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=214222','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=214222"><span><span class="hlt">Big</span> Sagebrush Seed Bank Densities Following Wildfires</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p><span class="hlt">Big</span> sagebrush (Artemisia sp.) is a critical shrub to such sagebrush obligate species as sage grouse, (Centocercus urophasianus), mule deer (Odocoileus hemionus), and pygmy rabbit (Brachylagus idahoensis). <span class="hlt">Big</span> sagebrush do not sprout after wildfires wildfires and <span class="hlt">big</span> sagebrush seed is generally sho...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=statistics+AND+industry&pg=3&id=EJ1024478','ERIC'); return false;" href="http://eric.ed.gov/?q=statistics+AND+industry&pg=3&id=EJ1024478"><span>Judging <span class="hlt">Big</span> Deals: Challenges, Outcomes, and Advice</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Glasser, Sarah</p> <p>2013-01-01</p> <p>This article reports the results of an analysis of five <span class="hlt">Big</span> Deal electronic journal packages to which Hofstra University's Axinn Library subscribes. COUNTER usage reports were used to judge the value of each <span class="hlt">Big</span> Deal. Limitations of usage statistics are also discussed. In the end, the author concludes that four of the five <span class="hlt">Big</span> Deals are good deals…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4617656','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4617656"><span>A survey of <span class="hlt">big</span> data research</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fang, Hua; Zhang, Zhaoyang; Wang, Chanpaul Jin; Daneshmand, Mahmoud; Wang, Chonggang; Wang, Honggang</p> <p>2015-01-01</p> <p><span class="hlt">Big</span> data create values for business and research, but pose significant challenges in terms of networking, storage, management, analytics and ethics. Multidisciplinary collaborations from engineers, computer scientists, statisticians and social scientists are needed to tackle, discover and understand <span class="hlt">big</span> data. This survey presents an overview of <span class="hlt">big</span> data initiatives, technologies and research in industries and academia, and discusses challenges and potential solutions. PMID:26504265</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3429432','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3429432"><span>The First Record of a Trans-Oceanic <span class="hlt">Sister</span>-Group Relationship between Obligate Vertebrate Troglobites</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chakrabarty, Prosanta; Davis, Matthew P.; Sparks, John S.</p> <p>2012-01-01</p> <p>We show using the most complete phylogeny of one of the most species-rich orders of vertebrates (Gobiiformes), and calibrations from the rich fossil record of teleost fishes, that the genus Typhleotris, endemic to subterranean karst habitats in southwestern Madagascar, is the <span class="hlt">sister</span> group to Milyeringa, endemic to similar subterranean systems in northwestern Australia. Both groups are eyeless, and our phylogenetic and biogeographic results show that these obligate cave fishes now found on opposite ends of the Indian Ocean (separated by nearly 7,000 km) are each others closest relatives and owe their origins to the break up of the southern supercontinent, Gondwana, at the end of the Cretaceous period. Trans-oceanic <span class="hlt">sister</span>-group relationships are otherwise unknown between blind, cave-adapted vertebrates and our results provide an extraordinary case of Gondwanan vicariance. PMID:22937155</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592785','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592785"><span>Bloom Helicase and DNA Topoisomerase IIIα Are Involved in the Dissolution of <span class="hlt">Sister</span> Chromatids</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Seki, Masayuki; Nakagawa, Takayuki; Seki, Takahiko; Kato, Genta; Tada, Shusuke; Takahashi, Yuriko; Yoshimura, Akari; Kobayashi, Takayuki; Aoki, Ayako; Otsuki, Makoto; Habermann, Felix A.; Tanabe, Hideyuki; Ishii, Yutaka; Enomoto, Takemi</p> <p>2006-01-01</p> <p>Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product whose mutation leads to BS is the RecQ family helicase BLM, which forms a complex with DNA topoisomerase IIIα (Top3α). However, the physiological relevance of the interaction between BLM and Top3α within the cell remains unclear. We show here that Top3α depletion causes accumulation of cells in G2 phase, enlargement of nuclei, and chromosome gaps and breaks that occur at the same position in <span class="hlt">sister</span> chromatids. The transition from metaphase to anaphase is also inhibited. All of these phenomena except cell lethality are suppressed by BLM gene disruption. Taken together with the biochemical properties of BLM and Top3α, these data indicate that BLM and Top3α execute the dissolution of <span class="hlt">sister</span> chromatids. PMID:16880537</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22937155','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22937155"><span>The first record of a trans-oceanic <span class="hlt">sister</span>-group relationship between obligate vertebrate troglobites.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chakrabarty, Prosanta; Davis, Matthew P; Sparks, John S</p> <p>2012-01-01</p> <p>We show using the most complete phylogeny of one of the most species-rich orders of vertebrates (Gobiiformes), and calibrations from the rich fossil record of teleost fishes, that the genus Typhleotris, endemic to subterranean karst habitats in southwestern Madagascar, is the <span class="hlt">sister</span> group to Milyeringa, endemic to similar subterranean systems in northwestern Australia. Both groups are eyeless, and our phylogenetic and biogeographic results show that these obligate cave fishes now found on opposite ends of the Indian Ocean (separated by nearly 7,000 km) are each others closest relatives and owe their origins to the break up of the southern supercontinent, Gondwana, at the end of the Cretaceous period. Trans-oceanic <span class="hlt">sister</span>-group relationships are otherwise unknown between blind, cave-adapted vertebrates and our results provide an extraordinary case of Gondwanan vicariance.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7510022','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7510022"><span>Lymphocyte proliferation kinetics and <span class="hlt">sister</span>-chromatid exchanges in individuals treated with metronidazole.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Elizondo, G; Montero, R; Herrera, J E; Hong, E; Ostrosky-Wegman, P</p> <p>1994-03-01</p> <p>Metronidazole, an effective agent for the treatment of protozoan infections, is frequently used in developing countries. However, the employment of this drug has been questioned in view of its mutagenicity in bacteria and carcinogenicity in mice. A genotoxic study was carried out in which cellular proliferation kinetics and the frequency of <span class="hlt">sister</span>-chromatid exchanges were determined in human peripheral blood lymphocytes from 12 individuals treated with therapeutic doses of metronidazole. No effect was observed on mitotic index with the treatment, although a significant increase was found in three individuals after treatment. No increase of <span class="hlt">sister</span>-chromatid exchanges was detected. The rate of lymphocyte proliferation kinetics showed an increase after the metronidazole treatment in all patients, indicating a possible immunostimulatory action.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19919691','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19919691"><span>Self-healing photo-neuropathy and cervical spinal arthrosis in four <span class="hlt">sisters</span> with brachioradial pruritus.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wallengren, Joanna</p> <p>2009-11-17</p> <p>The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four <span class="hlt">sisters</span> suffering from brachioradial pruritus recurring every summer. The <span class="hlt">sisters</span> spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervical radiographs indicated arthrosis. The density of sensory nerve fibers in the skin biopsies from the itchy skin of the arms, visualized by antibodies against a pan-neuronal marker, protein gene product 9.5, was reduced compared with biopsies from the same skin region during the symptom-free period in the winter. This data exemplifies that brachioradial pruritus is a self healing photoneuropathy occurring in middle aged adults predisposed by cervical arthrosis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2789710','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2789710"><span>Self-healing photo-neuropathy and cervical spinal arthrosis in four <span class="hlt">sisters</span> with brachioradial pruritus</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2009-01-01</p> <p>The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four <span class="hlt">sisters</span> suffering from brachioradial pruritus recurring every summer. The <span class="hlt">sisters</span> spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervical radiographs indicated arthrosis. The density of sensory nerve fibers in the skin biopsies from the itchy skin of the arms, visualized by antibodies against a pan-neuronal marker, protein gene product 9.5, was reduced compared with biopsies from the same skin region during the symptom-free period in the winter. This data exemplifies that brachioradial pruritus is a self healing photoneuropathy occurring in middle aged adults predisposed by cervical arthrosis. PMID:19919691</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/6052504','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/6052504"><span>Frequency of <span class="hlt">sister</span> chromatid exchange in peripheral lymphocytes of male pesticide applicators</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Rupa, D.S. ); Reddy, P.P. ); Sreemannarayana, K. ); Reddi, O.S. )</p> <p>1991-01-01</p> <p>In the present study 61 male pesticide applicators who worked in cotton fields and regularly sprayed pesticides such as DDT, BHC, endosulfan, malathion, methyl parathion, phosphamidon, dimethoate, monocrotophos, quinalphos fenvelrate, and cypermethrin were analyzed for <span class="hlt">sister</span> chromatid exchanges, mitotic index, and cell cycle kinetics in peripheral lymphocytes. Subjects who handled pesticides were non-smokers and teetotalers and the data were compared with the matched control group. Statistical analysis revealed that the frequency of <span class="hlt">sister</span> chromatid exchanges was significantly higher among the pesticide applicators at all the durations of exposure when compared to controls. Subjects exposed to pesticides also showed cell cycle delay and decrease in mitotic index when compared to the control group.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2101963','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2101963"><span>Congenital adrenal hyperplasia. I: Gender-related behavior and attitudes in female patients and <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dittmann, R W; Kappes, M H; Kappes, M E; Börger, D; Stegner, H; Willig, R H; Wallis, H</p> <p>1990-01-01</p> <p>Thirty-five female patients with congenital adrenal hyperplasia (CAH) were compared to a group of 16 healthy <span class="hlt">sisters</span> in regard to gender-related behavioral patterns, present attitudes, and plans for the future. A semi-structured interview with the subjects, ages 11 to 41 yr, and their mothers concentrated on four to five age stages. Results of retrospective data from single items as well as from several related composite scales ("interests and behavior," "appearance," "overall scores") revealed significant group differences: Both in mother-assessment and self-assessment, CAH patients showed a "more masculine" orientation than their <span class="hlt">sisters</span>, but this was far from consistent across all age stages, especially for single items. Unexpectedly, the gender-behavior differences between CAH patients and <span class="hlt">sisters</span> did not hold for certain items and scales of "social behavior" (e.g., assertiveness, dominance, acceptance in peer groups) and, in contrast to some of the existing literature, also not for "high-energy expenditure." With regard to expectations for the future, CAH patients had less of a "wish to have their own children" and a higher preference for "having a career versus staying at home." Age, socioeconomic status, intelligence, and presence or absence of a <span class="hlt">sister</span> as possibly intervening psychosocial/demographic factors could not explain the group differences in behavior. Degree of genital masculinization (Prader stages) or "onset and quality" of therapy as measures of pre- and postnatal androgenization, respectively, could also not account for the degree of the "more masculine" orientation in the CAH group. Nevertheless, the overall results are compatible with earlier findings on the masculinizing effects of prenatal androgens on behavior in humans and point to a time period after sexual differentiation of the genitalia and before birth as the most likely one for the effects of prenatal hormones on behavioral masculinization in humans.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1647488','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1647488"><span>Alaninuria, Associated with Microcephaly, Dwarfism, Enamel Hypoplasia, and Diabetes Mellitus in Two <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Stimmler, L.; Jensen, N.; Toseland, P.</p> <p>1970-01-01</p> <p>Two <span class="hlt">sisters</span>, both microcephalic at birth and of low birthweight, are described. They are both severely mentally retarded and dwarfed, and have developed diabetes mellitus. Their teeth show enamel hypoplasia. Excessive quantities of alanine were found in their urine, which was associated with high levels of alanine pyruvate and lactate in the blood. ImagesFIG. 1FIG. 2FIG. 3aFIG. 3b PMID:5477682</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA157372','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA157372"><span>Application of <span class="hlt">Sister</span> Chromatid Exchange in Marine Polychaetes to Black Rock Harbor Sediment. Laboratory Documentation Phase.</span></a></p> <p><a target="_blank" href="https://publicaccess.dtic.mil/psm/api/service/search/search">DTIC Science & Technology</a></p> <p></p> <p>1985-01-01</p> <p>Continue on reverse eide if necomeay and Identify by block number) Marine pollution --Genetic effects (LC) Polychaeta (LC) Dredged material (WES) Biological...necessary end Identify by block number) Marine pollution --Genetic effects (LC) Polychaeta (LC) Dredged material (WES) Biological assay (LC) <span class="hlt">Sister</span>...populations of marine organisms. 2. The importance of genetic effects in marine pollution studies has been recognized only recently. The International Council</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24162982','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24162982"><span>A historical overview of bromo-substituted DNA and <span class="hlt">sister</span> chromatid differentiation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mezzanotte, Roberto; Nieddu, Mariella</p> <p>2014-01-01</p> <p>The thymidine analogue 5-bromo-2'-deoxyuridine (BrdU) has been widely used to make <span class="hlt">sister</span> chromatid differentiation (SCD) evident in metaphase chromosomes of cells grown for two cycles in BrdU and, thus, containing varying amounts of the thymidine analogue. A direct consequence was the possibility of making <span class="hlt">sister</span> chromatid exchange (SCE) evident without using autoradiographic procedures. The latter phenomenon was first discovered in 1953, and its frequency is considered a reliable marker of pathological cell situations, as well as an indicator of mutagenic compounds. Several experimental procedures were found which produced SCD, such as the use of fluorochromes like 33258 Hoechst or acridine orange, whose observation under fluorescence microscopy was directly recorded by photos or stained with Giemsa to make chromosome preparations permanent. Other treatments followed by Giemsa staining required the use of saline hot solutions, acid solutions, nuclease attack and specific monoclonal antibodies. Basically two molecular mechanisms were invoked to explain the different affinity of Giemsa stain for differential BrdU-substituted chromatid DNA. The first implied debromination of chromatid DNA, whose occurrence would be greater in chromatids containing an amount of BrdU greater than that present in <span class="hlt">sister</span> chromatids. The second mechanism, although not denying the importance of DNA debromination, postulated that chromatin structural organization, in terms of DNA-protein and/or protein-protein DNA interaction, is responsible for SCD production.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749"><span><span class="hlt">Sister</span> kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zielinska, Agata P; Holubcova, Zuzana; Blayney, Martyn; Elder, Kay; Schuh, Melina</p> <p>2015-01-01</p> <p>Aneuploidy in human eggs is the leading cause of pregnancy loss and Down’s syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. Here, we show that many <span class="hlt">sister</span> kinetochores in human oocytes are separated and do not behave as a single functional unit during the first meiotic division. Having separated <span class="hlt">sister</span> kinetochores allowed bivalents to rotate by 90 degrees on the spindle and increased the risk of merotelic kinetochore-microtubule attachments. Advanced maternal age led to an increase in <span class="hlt">sister</span> kinetochore separation, rotated bivalents and merotelic attachments. Chromosome arm cohesion was weakened, and the fraction of bivalents that precociously dissociated into univalents was increased. Together, our data reveal multiple age-related changes in chromosome architecture that could explain why oocyte aneuploidy increases with advanced maternal age. DOI: http://dx.doi.org/10.7554/eLife.11389.001 PMID:26670547</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25257310','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25257310"><span>Functional genomics identifies a requirement of pre-mRNA splicing factors for <span class="hlt">sister</span> chromatid cohesion.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sundaramoorthy, Sriramkumar; Vázquez-Novelle, María Dolores; Lekomtsev, Sergey; Howell, Michael; Petronczki, Mark</p> <p>2014-11-18</p> <p><span class="hlt">Sister</span> chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation during cell division. Using functional genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for <span class="hlt">sister</span> chromatid cohesion in human cells. Loss of spliceosome subunits increases the dissociation rate of cohesin from chromatin and abrogates cohesion after DNA replication, ultimately causing mitotic catastrophe. Depletion of splicing factors causes defective processing of the pre-mRNA encoding sororin, a factor required for the stable association of cohesin with chromatin, and an associated reduction of sororin protein level. Expression of an intronless version of sororin and depletion of the cohesin release protein WAPL suppress the cohesion defect in cells lacking splicing factors. We propose that spliceosome components contribute to <span class="hlt">sister</span> chromatid cohesion and mitotic chromosome segregation through splicing of sororin pre-mRNA. Our results highlight the loss of cohesion as an early cellular consequence of compromised splicing. This may have clinical implications because SF3B1, a splicing factor that we identify to be essential for cohesion, is recurrently mutated in chronic lymphocytic leukaemia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3843825','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3843825"><span>Female rhesus macaques discriminate unfamiliar paternal <span class="hlt">sisters</span> in playback experiments: support for acoustic phenotype matching</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pfefferle, Dana; Ruiz-Lambides, Angelina V.; Widdig, Anja</p> <p>2014-01-01</p> <p>Widespread evidence exists that when relatives live together, kinship plays a central role in shaping the evolution of social behaviour. Previous studies showed that female rhesus macaques (Macaca mulatta) recognize familiar maternal kin using vocal cues. Recognizing paternal kin might, however, be more difficult as rhesus females mate promiscuously during the possible conception period, most probably concealing paternity. Behavioural observations indicate that semi free-ranging female rhesus macaques prefer to associate with their paternal half-<span class="hlt">sisters</span> in comparison to unrelated females within the same group, particularly when born within the same age cohort. However, the cues and mechanism/s used in paternal kin discrimination remain under debate. Here, we investigated whether female rhesus macaques use the acoustic modality to discriminate between paternal half-<span class="hlt">sisters</span> and non-kin, and tested familiarity and phenotype matching as the underlying mechanisms. We found that test females responded more often to calls of paternal half-<span class="hlt">sisters</span> compared with calls of unrelated females, and that this discrimination ability was independent of the level of familiarity between callers and test females, which provides, to our knowledge, the first evidence for acoustic phenotype matching. Our study strengthens the evidence that female rhesus macaques can recognize their paternal kin, and that vocalizations are used as a cue. PMID:24225452</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/sciencecinema/biblio/1011906','SCIGOVIMAGE-SCICINEMA'); return false;" href="http://www.osti.gov/sciencecinema/biblio/1011906"><span><span class="hlt">Big</span> Bang Day : The Great <span class="hlt">Big</span> Particle Adventure - 3. Origins</span></a></p> <p><a target="_blank" href="http://www.osti.gov/sciencecinema/">ScienceCinema</a></p> <p>None</p> <p>2016-07-12</p> <p>In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. If the LHC is successful, it will explain the nature of the Universe around us in terms of a few simple ingredients and a few simple rules. But the Universe now was forged in a <span class="hlt">Big</span> Bang where conditions were very different, and the rules were very different, and those early moments were crucial to determining how things turned out later. At the LHC they can recreate conditions as they were billionths of a second after the <span class="hlt">Big</span> Bang, before atoms and nuclei existed. They can find out why matter and antimatter didn't mutually annihilate each other to leave behind a Universe of pure, brilliant light. And they can look into the very structure of space and time - the fabric of the Universe</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhLB..715..278B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhLB..715..278B"><span>Antigravity and the <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang transition</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bars, Itzhak; Chen, Shih-Hung; Steinhardt, Paul J.; Turok, Neil</p> <p>2012-08-01</p> <p>We point out a new phenomenon which seems to be generic in 4d effective theories of scalar fields coupled to Einstein gravity, when applied to cosmology. A lift of such theories to a Weyl-invariant extension allows one to define classical evolution through cosmological singularities unambiguously, and hence construct geodesically complete background spacetimes. An attractor mechanism ensures that, at the level of the effective theory, generic solutions undergo a <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang transition by contracting to zero size, passing through a brief antigravity phase, shrinking to zero size again, and re-emerging into an expanding normal gravity phase. The result may be useful for the construction of complete bouncing cosmologies like the cyclic model.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/1011906','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/1011906"><span><span class="hlt">Big</span> Bang Day : The Great <span class="hlt">Big</span> Particle Adventure - 3. Origins</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>2009-10-13</p> <p>In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. If the LHC is successful, it will explain the nature of the Universe around us in terms of a few simple ingredients and a few simple rules. But the Universe now was forged in a <span class="hlt">Big</span> Bang where conditions were very different, and the rules were very different, and those early moments were crucial to determining how things turned out later. At the LHC they can recreate conditions as they were billionths of a second after the <span class="hlt">Big</span> Bang, before atoms and nuclei existed. They can find out why matter and antimatter didn't mutually annihilate each other to leave behind a Universe of pure, brilliant light. And they can look into the very structure of space and time - the fabric of the Universe</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/21027864','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/21027864"><span>Solution of a braneworld <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang cosmology</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>McFadden, Paul L.; Turok, Neil; Steinhardt, Paul J.</p> <p>2007-11-15</p> <p>We solve for the cosmological perturbations in a five-dimensional background consisting of two separating or colliding boundary branes, as an expansion in the collision speed V divided by the speed of light c. Our solution permits a detailed check of the validity of four-dimensional effective theory in the vicinity of the event corresponding to the <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang singularity. We show that the four-dimensional description fails at the first nontrivial order in (V/c){sup 2}. At this order, there is nontrivial mixing of the two relevant four-dimensional perturbation modes (the growing and decaying modes) as the boundary branes move from the narrowly separated limit described by Kaluza-Klein theory to the well-separated limit where gravity is confined to the positive-tension brane. We comment on the cosmological significance of the result and compute other quantities of interest in five-dimensional cosmological scenarios.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf"><span>77 FR 66851 - Submission for OMB Review; Comment Request The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-07</p> <p>... risk factors for the development of breast cancer in a high-risk cohort of <span class="hlt">sisters</span> of women who have... relevant genes and/or exposures, further enhancing the ability to detect gene-environment...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23122964','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23122964"><span>Cyclin A2 is required for <span class="hlt">sister</span> chromatid segregation, but not separase control, in mouse oocyte meiosis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Touati, Sandra A; Cladière, Damien; Lister, Lisa M; Leontiou, Ioanna; Chambon, Jean-Philippe; Rattani, Ahmed; Böttger, Franziska; Stemmann, Olaf; Nasmyth, Kim; Herbert, Mary; Wassmann, Katja</p> <p>2012-11-29</p> <p>In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of <span class="hlt">sister</span> chromatids. Separase removes the cohesin complex holding <span class="hlt">sister</span> chromatids together in a stepwise manner from chromosome arms in meiosis I, then from the centromere region in meiosis II. Using mouse oocytes, our study reveals that cyclin A2 promotes entry into meiosis, as well as an additional unexpected role; namely, its requirement for separase-dependent <span class="hlt">sister</span> chromatid separation in meiosis II. Untimely cyclin A2-associated kinase activity in meiosis I leads to precocious <span class="hlt">sister</span> separation, whereas inhibition of cyclin A2 in meiosis II prevents it. Accordingly, endogenous cyclin A is localized to kinetochores throughout meiosis II, but not in anaphase I. Additionally, we found that cyclin B1, but not cyclin A2, inhibits separase in meiosis I. These findings indicate that separase-dependent cohesin removal is differentially regulated by cyclin B1 and A2 in mammalian meiosis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26844660','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26844660"><span><span class="hlt">Big</span> data and ophthalmic research.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Clark, Antony; Ng, Jonathon Q; Morlet, Nigel; Semmens, James B</p> <p>2016-01-01</p> <p>Large population-based health administrative databases, clinical registries, and data linkage systems are a rapidly expanding resource for health research. Ophthalmic research has benefited from the use of these databases in expanding the breadth of knowledge in areas such as disease surveillance, disease etiology, health services utilization, and health outcomes. Furthermore, the quantity of data available for research has increased exponentially in recent times, particularly as e-health initiatives come online in health systems across the globe. We review some <span class="hlt">big</span> data concepts, the databases and data linkage systems used in eye research-including their advantages and limitations, the types of studies previously undertaken, and the future direction for <span class="hlt">big</span> data in eye research.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669"><span>Chl1p, a DNA helicase-like protein in budding yeast, functions in <span class="hlt">sister</span>-chromatid cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skibbens, Robert V</p> <p>2004-01-01</p> <p>From the time of DNA replication until anaphase onset, <span class="hlt">sister</span> chromatids remain tightly paired along their length. Ctf7p/Eco1p is essential to establish <span class="hlt">sister</span>-chromatid pairing during S-phase and associates with DNA replication components. DNA helicases precede the DNA replication fork and thus will first encounter chromatin sites destined for cohesion. In this study, I provide the first evidence that a DNA helicase is required for proper <span class="hlt">sister</span>-chromatid cohesion. Characterizations of chl1 mutant cells reveal that CHL1 interacts genetically with both CTF7/ECO1 and CTF18/CHL12, two genes that function in <span class="hlt">sister</span>-chromatid cohesion. Consistent with genetic interactions, Chl1p physically associates with Ctf7p/Eco1p both in vivo and in vitro. Finally, a functional assay reveals that Chl1p is critical for <span class="hlt">sister</span>-chromatid cohesion. Within the budding yeast genome, Chl1p exhibits the highest degree of sequence similarity to human CHL1 isoforms and BACH1. Previous studies revealed that human CHLR1 exhibits DNA helicase-like activities and that BACH1 is a helicase-like protein that associates with the tumor suppressor BRCA1 to maintain genome integrity. Our findings document a novel role for Chl1p in <span class="hlt">sister</span>-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated. PMID:15020404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21841892','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21841892"><span>Statistical Inference: The <span class="hlt">Big</span> Picture.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kass, Robert E</p> <p>2011-02-01</p> <p>Statistics has moved beyond the frequentist-Bayesian controversies of the past. Where does this leave our ability to interpret results? I suggest that a philosophy compatible with statistical practice, labelled here statistical pragmatism, serves as a foundation for inference. Statistical pragmatism is inclusive and emphasizes the assumptions that connect statistical models with observed data. I argue that introductory courses often mis-characterize the process of statistical inference and I propose an alternative "<span class="hlt">big</span> picture" depiction.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Lee%2c+In&pg=5&id=EJ1008532','ERIC'); return false;" href="http://eric.ed.gov/?q=Lee%2c+In&pg=5&id=EJ1008532"><span>District Bets <span class="hlt">Big</span> on Standards</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Gewertz, Catherine</p> <p>2013-01-01</p> <p>The <span class="hlt">big</span> clock in Dowan McNair-Lee's 8th grade classroom in the Stuart-Hobson Middle School is silent, but she can hear the minutes ticking away nonetheless. On this day, like any other, the clock is a constant reminder of how little time she has to prepare her students--for spring tests, and for high school and all that lies beyond it. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2001gbb..book.....A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2001gbb..book.....A"><span>Genesis of the <span class="hlt">big</span> bang</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alpher, Ralph A.; Herman, Robert</p> <p></p> <p>The authors of this volume have been intimately connected with the conception of the <span class="hlt">big</span> bang model since 1947. Following the late George Gamov's ideas in 1942 and more particularly in 1946 that the early universe was an appropriate site for the synthesis of the elements, they became deeply involved in the question of cosmic nucleosynthesis and particularly the synthesis of the light elements. In the course of this work they developed a general relativistic model of the expanding universe with physics folded in, which led in a progressive, logical sequence to our prediction of the existence of a present cosmic background radiation some seventeen years before the observation of such radiation was reported by Penzias and Wilson. In addition, they carried out with James W. Follin, Jr., a detailed study of the physics of what was then considered to be the very early universe, starting a few seconds after the <span class="hlt">big</span> bang, which still provides a methodology for studies of light element nucleosynthesis. Because of their involvement, they bring a personal perspective to the subject. They present a picture of what is now believed to be the state of knowledge about the evolution of the expanding universe and delineate the story of the development of the <span class="hlt">big</span> bang model as they have seen and lived it from their own unique vantage point.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23074865','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23074865"><span><span class="hlt">Big</span> data: the management revolution.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McAfee, Andrew; Brynjolfsson, Erik</p> <p>2012-10-01</p> <p><span class="hlt">Big</span> data, the authors write, is far more powerful than the analytics of the past. Executives can measure and therefore manage more precisely than ever before. They can make better predictions and smarter decisions. They can target more-effective interventions in areas that so far have been dominated by gut and intuition rather than by data and rigor. The differences between <span class="hlt">big</span> data and analytics are a matter of volume, velocity, and variety: More data now cross the internet every second than were stored in the entire internet 20 years ago. Nearly real-time information makes it possible for a company to be much more agile than its competitors. And that information can come from social networks, images, sensors, the web, or other unstructured sources. The managerial challenges, however, are very real. Senior decision makers have to learn to ask the right questions and embrace evidence-based decision making. Organizations must hire scientists who can find patterns in very large data sets and translate them into useful business information. IT departments have to work hard to integrate all the relevant internal and external sources of data. The authors offer two success stories to illustrate how companies are using <span class="hlt">big</span> data: PASSUR Aerospace enables airlines to match their actual and estimated arrival times. Sears Holdings directly analyzes its incoming store data to make promotions much more precise and faster.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287080','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287080"><span>EHR <span class="hlt">Big</span> Data Deep Phenotyping</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lenert, L.; Lopez-Campos, G.</p> <p>2014-01-01</p> <p>Summary Objectives Given the quickening speed of discovery of variant disease drivers from combined patient genotype and phenotype data, the objective is to provide methodology using <span class="hlt">big</span> data technology to support the definition of deep phenotypes in medical records. Methods As the vast stores of genomic information increase with next generation sequencing, the importance of deep phenotyping increases. The growth of genomic data and adoption of Electronic Health Records (EHR) in medicine provides a unique opportunity to integrate phenotype and genotype data into medical records. The method by which collections of clinical findings and other health related data are leveraged to form meaningful phenotypes is an active area of research. Longitudinal data stored in EHRs provide a wealth of information that can be used to construct phenotypes of patients. We focus on a practical problem around data integration for deep phenotype identification within EHR data. The use of <span class="hlt">big</span> data approaches are described that enable scalable markup of EHR events that can be used for semantic and temporal similarity analysis to support the identification of phenotype and genotype relationships. Conclusions Stead and colleagues’ 2005 concept of using light standards to increase the productivity of software systems by riding on the wave of hardware/processing power is described as a harbinger for designing future healthcare systems. The <span class="hlt">big</span> data solution, using flexible markup, provides a route to improved utilization of processing power for organizing patient records in genotype and phenotype research. PMID:25123744</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19042463','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19042463"><span>Our brotherhood and your <span class="hlt">sister</span>: building anti-rape community in the fraternity.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wantland, Ross A</p> <p>2008-01-01</p> <p>Research shows that male peer influence is a significant predictor of violent sexual behavior. However, men challenging sexual violence within their male peer communities may exert a counter-influence, shifting community norms and behaviors. Using the Fraternity Peer Rape Education Program as a case study, this article examines the ways that fraternity men in a peer rape education program make sense of and interact within their communities. Through coded interviews, this article examines participants' perceptions of change within themselves, within their interactions with fraternity <span class="hlt">brothers</span>, and within their fraternities. Learning about sexual violence altered participants' worldview and created a communal sense of partnership and responsibility, while simultaneously limiting the traditional ways that fraternal communities are maintained. This experience provides lessons for how we may begin creating communities of men against sexual violence, as well as what support may be required for such messy, nonlinear change processes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED569213.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED569213.pdf"><span>Development of Boys and Young Men of Color: Implications of Developmental Science for My <span class="hlt">Brother</span>'s Keeper Initiative. Social Policy Report. Volume 29, Number 3</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Barbarin, Oscar A.; Murry, Velma McBride; Tolan, Patrick; Graham, Sandra</p> <p>2016-01-01</p> <p>Boys and men of color (BMOC) are at significant risks for poor outcomes across multiple domains including education, health, and financial well-being with little promise of improvement in the near future. Out of concern for this situation, President Obama instituted the My <span class="hlt">Brother</span>'s Keeper Initiative (MBKI) to enlist the combined resources of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/21308618','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/21308618"><span>Turning <span class="hlt">big</span> bang into <span class="hlt">big</span> bounce. I. Classical dynamics</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dzierzak, Piotr; Malkiewicz, Przemyslaw; Piechocki, Wlodzimierz</p> <p>2009-11-15</p> <p>The <span class="hlt">big</span> bounce (BB) transition within a flat Friedmann-Robertson-Walker model is analyzed in the setting of loop geometry underlying the loop cosmology. We solve the constraint of the theory at the classical level to identify physical phase space and find the Lie algebra of the Dirac observables. We express energy density of matter and geometrical functions in terms of the observables. It is the modification of classical theory by the loop geometry that is responsible for BB. The classical energy scale specific to BB depends on a parameter that should be fixed either by cosmological data or determined theoretically at quantum level, otherwise the energy scale stays unknown.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec633-320.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec633-320.pdf"><span>20 CFR 633.320 - Nepotism.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... family” means wife, husband, son, daughter, mother, father, <span class="hlt">brother</span>, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>, <span class="hlt">sister</span>-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.cancer.org/cancer/leukemia-in-children/causes-risks-prevention/risk-factors.html','NIH-MEDLINEPLUS'); return false;" href="https://www.cancer.org/cancer/leukemia-in-children/causes-risks-prevention/risk-factors.html"><span>What Are the Risk Factors for Childhood Leukemia?</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Prevention What Are the Risk Factors for Childhood Leukemia? A risk factor is anything that affects a ... of leukemia. Having a <span class="hlt">brother</span> or <span class="hlt">sister</span> with leukemia Siblings (<span class="hlt">brothers</span> and <span class="hlt">sisters</span>) of children with leukemia ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol3/pdf/CFR-2012-title20-vol3-sec633-320.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol3/pdf/CFR-2012-title20-vol3-sec633-320.pdf"><span>20 CFR 633.320 - Nepotism.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... family” means wife, husband, son, daughter, mother, father, <span class="hlt">brother</span>, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>, <span class="hlt">sister</span>-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1484498','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1484498"><span>Metazoan Scc4 Homologs Link <span class="hlt">Sister</span> Chromatid Cohesion to Cell and Axon Migration Guidance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Seitan, Vlad C; Banks, Peter; Laval, Steve; Majid, Nazia A; Dorsett, Dale; Rana, Amer; Smith, Jim; Bateman, Alex; Krpic, Sanja; Hostert, Arnd; Rollins, Robert A; Erdjument-Bromage, Hediye; Tempst, Paul; Benard, Claire Y; Hekimi, Siegfried; Newbury, Sarah F</p> <p>2006-01-01</p> <p>Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating <span class="hlt">sister</span> chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein–protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious <span class="hlt">sister</span> chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that <span class="hlt">sister</span> chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development. PMID:16802858</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/447701','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/447701"><span>Fanconi anemia in <span class="hlt">brothers</span> initially diagnosed with VACTERL association with hydrocephalus, and subsequently with Baller-Gerold syndrome</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Rossbach, H.C.; Granan, N.H.; Rossi, A.R.; Barbosa, J.L.</p> <p>1996-01-02</p> <p>Two <span class="hlt">brothers</span> with presumed Baller-Gerold syndrome, one of whom was previously diagnosed with the association of vertebral, cardiac, renal, limb anomalies, anal atresia, tracheo-esophageal fistula (VACTERL) association with hydrocephalus, were evaluated for chromosome breakage because of severe thrombo cytopenia in one of them. Spontaneous and clastogen-induced breakage was markedly increased in both patients as compared to control individuals. Clinical manifestations and chromosome breakage, consistent with Fanconi anemia, in patients with a prior diagnosis of either Baller-Gerold syndrome, reported earlier in one other patient, or with VACTERL association with hydrocephalus, recently reported in 3 patients, underline the clinical heterogeneity of Fanconi anemia and raise the question of whether these syndromes are distinct disorders or phenotypic variations of the same disease. 12 refs., 3 figs., 1 tab.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011AGUFM.V13B2592B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011AGUFM.V13B2592B"><span>Distribution of trace elements including tellurium, gallium, indium, and select REE in sulfide chimneys from <span class="hlt">Brothers</span> submarine volcano, Kermadec arc</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Berkenbosch, H. A.; de Ronde, C. E.; McNeill, A.; Goemann, K.; Gemmell, J. B.</p> <p>2011-12-01</p> <p><span class="hlt">Brothers</span> volcano is a dacitic volcano located along the Kermadec arc, New Zealand, and hosts the NW Caldera hydrothermal vent field perched on part of the steep caldera walls. The field strikes for ~600 m between depths of 1550 and 1700 m and includes numerous, active, high-temperature (max 302°C) chimneys and even more dead, sulfide-rich spires. Chimney samples collected from <span class="hlt">Brothers</span> show distinct mineralogical zonation reflecting gradients in oxidation state, temperature, and pH from the inner walls in contact with hydrothermal fluids through to the outer walls in contact with seawater. Minerals deposited from hotter fluids (e.g., chalcopyrite) are located in the interior of the chimneys and are surrounded by an external zone of minerals deposited by cooler fluids (e.g., sulfates, sphalerite). Four chimneys types are identified at <span class="hlt">Brothers</span> volcano based on the relative proportions of chalcopyrite and sulfate layers, and the presence or absence of anhydrite. Two are Cu-rich, i.e., chalcopyrite-rich and chalcopyrite-bornite-rich chimneys, and two are Zn-rich, i.e., sphalerite-rich and sphalerite-chalcopyrite-rich. Barite and anhydrite are common to both Cu-rich chimney types whereas Zn-rich chimneys contain barite only. The main mineral phases in all the chimneys are anhydrite, barite, chalcopyrite, pyrite/marcasite, and sphalerite. Trace minerals include galena, covellite, tennantite, realgar, chalcocite, bornite, hematite, goethite, Pb-As sulfosalts, and Bi- or Au-tellurides. The vast majority of tellurides are <5 μm in size, although columnar crystals up to 80 μm long have been observed. The tellurides commonly form in bands, cluster in patches, or occur along internal grain boundaries within chalcopyrite. They also are found at the contact between chalcopyrite and pyrite grains. In sulfate layers adjacent to the chalcopyrite zones tellurides can occur as inclusions in anhydrite, barite or pyrite and/or occupy void space within the chimney. One Cu</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4532644','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4532644"><span>A Comparison of Referred Sexual Partners to Their Community Recruited Counterparts in The <span class="hlt">BROTHERS</span> Project (HPTN 061)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Li, Keala; Wilton, Leo; Wheeler, Darrell; Fogel, Jessica; Wang, Lei; Koblin, Beryl</p> <p>2015-01-01</p> <p>The <span class="hlt">BROTHERS</span> Project (HPTN 061) was established to determine the feasibility and acceptability of a multi-component intervention among African American MSM to reduce HIV incidence. The goal of this analysis was to determine if the sexual partner referral approach used in HPTN 061 broadened the reach of recruitment with regards to characteristics associated with higher infection rates and barriers to quality health care. Overall, referred sexual partners had notable structural barrier differences in comparison to community-recruited participants: lower income, less education, higher unemployment, HIV positive diagnosis, incarceration history, and no health insurance. The study’s findings pose implications for utilizing the sexual partner referral approach in reaching African American MSM who may not be accessed by traditional recruitment methods or who are well-integrated in health care systems. PMID:25874753</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3667490','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3667490"><span>Information dissipation as an early-warning signal for the Lehman <span class="hlt">Brothers</span> collapse in financial time series</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Quax, Rick; Kandhai, Drona; Sloot, Peter M. A.</p> <p>2013-01-01</p> <p>In financial markets, participants locally optimize their profit which can result in a globally unstable state leading to a catastrophic change. The largest crash in the past decades is the bankruptcy of Lehman <span class="hlt">Brothers</span> which was followed by a trust-based crisis between banks due to high-risk trading in complex products. We introduce information dissipation length (IDL) as a leading indicator of global instability of dynamical systems based on the transmission of Shannon information, and apply it to the time series of USD and EUR interest rate swaps (IRS). We find in both markets that the IDL steadily increases toward the bankruptcy, then peaks at the time of bankruptcy, and decreases afterwards. Previously introduced indicators such as ‘critical slowing down' do not provide a clear leading indicator. Our results suggest that the IDL may be used as an early-warning signal for critical transitions even in the absence of a predictive model. PMID:23719567</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=263285','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=263285"><span>Bacteriological study of periodontal lesions in two <span class="hlt">sisters</span> with juvenile periodontitis and their mother.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Okuda, K; Naito, Y; Ohta, K; Fukumoto, Y; Kimura, Y; Ishikawa, I; Kinoshita, S; Takazoe, I</p> <p>1984-01-01</p> <p>A total of five bacteriological samples from the periodontal pockets of two <span class="hlt">sisters</span> with localized juvenile periodontitis and their mother with advanced periodontitis was studied. Gram-negative anaerobic rods were predominant in the samples. Bacteroides intermedius and Bacteroides loescheii were the most predominant species. The antigenicity and bacteriocinogenicity of these isolates were quite similar. Serum immunoglobulin G antibody levels of the subjects to gram-negative periodontopathic bacteria were measured by using the micro-enzyme-linked immunosorbent assay. The levels of antibodies to saccharolytic black-pigmented Bacteroides species were significantly higher than the levels in healthy young females. Images PMID:6429040</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4775908','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4775908"><span>Mitochondrial Genes Reveal Triatoma jatai as a <span class="hlt">Sister</span> Species to Triatoma costalimai (Reduviidae: Triatominae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Teves, Simone Caldas; Gardim, Sueli; Carbajal de la Fuente, Ana Laura; Lopes, Catarina Macedo; Gonçalves, Teresa Cristina Monte; Mallet, Jacenir Reis dos Santos; da Rosa, João Aristeu; Almeida, Carlos Eduardo</p> <p>2016-01-01</p> <p>Triatoma jatai was described using a set of morphological structures from specimens collected in Paranã municipality of Tocantins State, Brazil. Under a Bayesian framework and using two mitochondrial genes (16S and COI), phylogenetic analysis recovered T. jatai as a <span class="hlt">sister</span> species to Triatoma costalimai with higher genetic distances than between other well-recognized species. Our results agree with previous suggestions based on morphometric analysis. In the light of the non-monophyly of Matogrossensis subcomplex, the inclusion of T. jatai shall be considered for reevaluating this group. PMID:26787157</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26787157','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26787157"><span>Mitochondrial Genes Reveal Triatoma jatai as a <span class="hlt">Sister</span> Species to Triatoma costalimai (Reduviidae: Triatominae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Teves, Simone Caldas; Gardim, Sueli; Carbajal de la Fuente, Ana Laura; Lopes, Catarina Macedo; Gonçalves, Teresa Cristina Monte; dos Santos Mallet, Jacenir Reis; da Rosa, João Aristeu; Almeida, Carlos Eduardo</p> <p>2016-03-01</p> <p>Triatoma jatai was described using a set of morphological structures from specimens collected in Paranã municipality of Tocantins State, Brazil. Under a Bayesian framework and using two mitochondrial genes (16S and COI), phylogenetic analysis recovered T. jatai as a <span class="hlt">sister</span> species to Triatoma costalimai with higher genetic distances than between other well-recognized species. Our results agree with previous suggestions based on morphometric analysis. In the light of the non-monophyly of Matogrossensis subcomplex, the inclusion of T. jatai shall be considered for reevaluating this group.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/254004','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/254004"><span><span class="hlt">Sister</span> chromatid exchange analysis to monitor genotoxic chemicals. (Latest citations from Pollution abstracts). Published Search</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>1996-04-01</p> <p>The bibliography contains citations concerning the use of the <span class="hlt">sister</span> chromatid exchange (SCE) analysis for toxicological studies. SCE analysis are very sensitive measures of genotoxic damage to chromosomes. SCE toxicological studies analyzing ionizing radiation, chromium compounds, styrene, paint thinner, mercury, cigarette smoke, coal dust, fuel oil, insecticides, ethylene oxide, diesel exhaust, and polychlorinated biphenyls are discussed. SCE studies using both human and animal tissue cultures are described. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/58452','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/58452"><span>Geologic map of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes, Lane, and Linn counties, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Taylor, E.M.; MacLeod, N.S.; Sherrod, D.R.; Walker, G.W.</p> <p>1987-01-01</p> <p>The Wilderness Act (Public Law 88-577, September 3, 1964) and related acts require the U.S. Geological Survey and the U.S. Bureau of Mines to survey certain areas on Federal lands to determine the mineral values, if any, that may be present. Results must be made available to the public and to be submitted to the President and Congress. This report presents the results of a geologic survey of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes and Willamette National Forests, Deschutes, Lane and Linn Counties, Oregon</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23395177','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23395177"><span>Shigella strains are not clones of Escherichia coli but <span class="hlt">sister</span> species in the genus Escherichia.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zuo, Guanghong; Xu, Zhao; Hao, Bailin</p> <p>2013-02-01</p> <p>Shigella species and Escherichia coli are closely related organisms. Early phenotyping experiments and several recent molecular studies put Shigella within the species E. coli. However, the whole-genome-based, alignment-free and parameter-free CVTree approach shows convincingly that four established Shigella species, Shigella boydii, Shigella sonnei, Shigella felxneri and Shigella dysenteriae, are distinct from E. coli strains, and form <span class="hlt">sister</span> species to E. coli within the genus Escherichia. In view of the overall success and high resolution power of the CVTree approach, this result should be taken seriously. We hope that the present report may promote further in-depth study of the Shigella-E. coli relationship.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3261041','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3261041"><span>Resurrection of the genus Staphisagria J. Hill, <span class="hlt">sister</span> to all the other Delphinieae (Ranunculaceae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jabbour, Florian; Renner, Susanne S.</p> <p>2011-01-01</p> <p>Abstract Molecular sequence data show that the three species oDelphinium subg. Staphisagria (J. Hill) Peterm. form the <span class="hlt">sister</span> clade to Aconitum L., Aconitella SpachConsolida (DC.) S.F. Gray, and all remaining species of Delphinium L. To account for this finding we resurrect Staphisagria J. Hill (1756). Names in Staphisagria are available for two of the species. We here make the required new combination for the third species, Staphisagria picta (Willd.) F. Jabbour, provide a key to the species, and illustrate one of them. PMID:22287922</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25401907','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25401907"><span>Dark three-<span class="hlt">sister</span> rogue waves in normally dispersive optical fibers with random birefringence.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Shihua; Soto-Crespo, Jose M; Grelu, Philippe</p> <p>2014-11-03</p> <p>We investigate dark rogue wave dynamics in normally dispersive birefringent optical fibers, based on the exact rational solutions of the coupled nonlinear Schrödinger equations. Analytical solutions are derived up to the second order via a nonrecursive Darboux transformation method. Vector dark "three-<span class="hlt">sister</span>" rogue waves as well as their existence conditions are demonstrated. The robustness against small perturbations is numerically confirmed in spite of the onset of modulational instability, offering the possibility to observe such extreme events in normal optical fibers with random birefringence, or in other Manakov-type vector nonlinear media.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16737839','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16737839"><span>Three <span class="hlt">sisters</span> with very-late-onset major depression and parkinsonism.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sechi, GianPietro; Antonio Cocco, Giovanni; Errigo, Alessandra; Deiana, Luca; Rosati, Giulio; Agnetti, Virgilio; Stephen Paulus, Kay; Mario Pes, Giovanni</p> <p>2007-03-01</p> <p>Familiar Parkinson's disease has an age of onset from the second to the sixth decade, whereas Wilson's disease (WD) usually presents in the first decade of life. We studied three <span class="hlt">sisters</span> with a form of very-late-onset major depression and parkinsonism with probable linkage to ATP7B gene. Molecular studies demonstrated a nucleotide deletion at the 5'UTR region in a single allele of ATP7B gene. They did not have a family history of WD, or markers indicative for copper deposition in peripheral tissues. We suggest that single allele mutations of ATP7B gene may confer a susceptibility for late-onset major depression and parkinsonism.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12516290','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12516290"><span>[Partial lipodystrophy in two HLA identical <span class="hlt">sisters</span> with hypocomplementemia and nephropathy].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Peces, R</p> <p>2002-01-01</p> <p>Partial lipodystrophy is a rare disorder with both autosomal recessive and familial forms. The cutaneous findings, which are often subtle, consist of gradual loss of subcutaneous fat from the face and upper body. Low levels of C3 and the presence of C3NeF help to identify these patients. Associated systemic abnormalities include the development of membranoproliferative glomerulonephritis, insulin resistance and an increased incidence of autoimmune diseases. We report here two HLA identical <span class="hlt">sisters</span> with the typical features of partial lipodystrophy associated with recurrent infections, low levels of C3, and nephropathy. Our data suggest an autosomal recessive transmission. We discuss the genetic and molecular basis of this rare association.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/254378','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/254378"><span>Two <span class="hlt">sisters</span> with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kondoh, T.; Hayashi, K.; Matsumoto, T.</p> <p>1995-10-09</p> <p>We report two <span class="hlt">sisters</span> in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disorder. An elder <span class="hlt">sister</span> had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger <span class="hlt">sister</span> had the same manifestations as the elder <span class="hlt">sister`s</span> for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder <span class="hlt">sister</span> a 115-KD band that should be specific for sialophorin was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each <span class="hlt">sister</span> had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-linked WAS. 17 refs., 6 figs., 1 tab.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1014086','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1014086"><span><span class="hlt">Big</span> Machines and <span class="hlt">Big</span> Science: 80 Years of Accelerators at Stanford</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Loew, Gregory</p> <p>2008-12-16</p> <p>Longtime SLAC physicist Greg Loew will present a trip through SLAC's origins, highlighting its scientific achievements, and provide a glimpse of the lab's future in '<span class="hlt">Big</span> Machines and <span class="hlt">Big</span> Science: 80 Years of Accelerators at Stanford.'</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25023020','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25023020"><span><span class="hlt">Big</span> data: an introduction for librarians.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hoy, Matthew B</p> <p>2014-01-01</p> <p>Modern life produces data at an astounding rate and shows no signs of slowing. This has lead to new advances in data storage and analysis and the concept of "<span class="hlt">big</span> data," that is, massive data sets that can yield surprising insights when analyzed. This column will briefly describe what <span class="hlt">big</span> data is and why it is important. It will also briefly explore the possibilities and problems of <span class="hlt">big</span> data and the implications it has for librarians. A list of <span class="hlt">big</span> data projects and resources is also included.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28392994','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28392994"><span>Medical <span class="hlt">big</span> data: promise and challenges.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lee, Choong Ho; Yoon, Hyung-Jin</p> <p>2017-03-01</p> <p>The concept of <span class="hlt">big</span> data, commonly characterized by volume, variety, velocity, and veracity, goes far beyond the data type and includes the aspects of data analysis, such as hypothesis-generating, rather than hypothesis-testing. <span class="hlt">Big</span> data focuses on temporal stability of the association, rather than on causal relationship and underlying probability distribution assumptions are frequently not required. Medical <span class="hlt">big</span> data as material to be analyzed has various features that are not only distinct from <span class="hlt">big</span> data of other disciplines, but also distinct from traditional clinical epidemiology. <span class="hlt">Big</span> data technology has many areas of application in healthcare, such as predictive modeling and clinical decision support, disease or safety surveillance, public health, and research. <span class="hlt">Big</span> data analytics frequently exploits analytic methods developed in data mining, including classification, clustering, and regression. Medical <span class="hlt">big</span> data analyses are complicated by many technical issues, such as missing values, curse of dimensionality, and bias control, and share the inherent limitations of observation study, namely the inability to test causality resulting from residual confounding and reverse causation. Recently, propensity score analysis and instrumental variable analysis have been introduced to overcome these limitations, and they have accomplished a great deal. Many challenges, such as the absence of evidence of practical benefits of <span class="hlt">big</span> data, methodological issues including legal and ethical issues, and clinical integration and utility issues, must be overcome to realize the promise of medical <span class="hlt">big</span> data as the fuel of a continuous learning healthcare system that will improve patient outcome and reduce waste in areas including nephrology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/22307937','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/22307937"><span>Traffic information computing platform for <span class="hlt">big</span> data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Duan, Zongtao Li, Ying Zheng, Xibin Liu, Yan Dai, Jiting Kang, Jun</p> <p>2014-10-06</p> <p><span class="hlt">Big</span> data environment create data conditions for improving the quality of traffic information service. The target of this article is to construct a traffic information computing platform for <span class="hlt">big</span> data environment. Through in-depth analysis the connotation and technology characteristics of <span class="hlt">big</span> data and traffic information service, a distributed traffic atomic information computing platform architecture is proposed. Under the <span class="hlt">big</span> data environment, this type of traffic atomic information computing architecture helps to guarantee the traffic safety and efficient operation, more intelligent and personalized traffic information service can be used for the traffic information users.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5331970','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5331970"><span>Medical <span class="hlt">big</span> data: promise and challenges</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lee, Choong Ho; Yoon, Hyung-Jin</p> <p>2017-01-01</p> <p>The concept of <span class="hlt">big</span> data, commonly characterized by volume, variety, velocity, and veracity, goes far beyond the data type and includes the aspects of data analysis, such as hypothesis-generating, rather than hypothesis-testing. <span class="hlt">Big</span> data focuses on temporal stability of the association, rather than on causal relationship and underlying probability distribution assumptions are frequently not required. Medical <span class="hlt">big</span> data as material to be analyzed has various features that are not only distinct from <span class="hlt">big</span> data of other disciplines, but also distinct from traditional clinical epidemiology. <span class="hlt">Big</span> data technology has many areas of application in healthcare, such as predictive modeling and clinical decision support, disease or safety surveillance, public health, and research. <span class="hlt">Big</span> data analytics frequently exploits analytic methods developed in data mining, including classification, clustering, and regression. Medical <span class="hlt">big</span> data analyses are complicated by many technical issues, such as missing values, curse of dimensionality, and bias control, and share the inherent limitations of observation study, namely the inability to test causality resulting from residual confounding and reverse causation. Recently, propensity score analysis and instrumental variable analysis have been introduced to overcome these limitations, and they have accomplished a great deal. Many challenges, such as the absence of evidence of practical benefits of <span class="hlt">big</span> data, methodological issues including legal and ethical issues, and clinical integration and utility issues, must be overcome to realize the promise of medical <span class="hlt">big</span> data as the fuel of a continuous learning healthcare system that will improve patient outcome and reduce waste in areas including nephrology. PMID:28392994</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhTea..53..140L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhTea..53..140L"><span>The LHC's Next <span class="hlt">Big</span> Mystery</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lincoln, Don</p> <p>2015-03-01</p> <p>When the sun rose over America on July 4, 2012, the world of science had radically changed. The Higgs boson had been discovered. Mind you, the press releases were more cautious than that, with "a new particle consistent with being the Higgs boson" being the carefully constructed phrase of the day. But, make no mistake, champagne corks were popped and backs were slapped. The data had spoken and a party was in order. Even if the observation turned out to be something other than the Higgs boson, the first <span class="hlt">big</span> discovery from data taken at the Large Hadron Collider had been made.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24854790','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24854790"><span>The faces of <span class="hlt">Big</span> Science.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schatz, Gottfried</p> <p>2014-06-01</p> <p>Fifty years ago, academic science was a calling with few regulations or financial rewards. Today, it is a huge enterprise confronted by a plethora of bureaucratic and political controls. This change was not triggered by specific events or decisions but reflects the explosive 'knee' in the exponential growth that science has sustained during the past three-and-a-half centuries. Coming to terms with the demands and benefits of '<span class="hlt">Big</span> Science' is a major challenge for today's scientific generation. Since its foundation 50 years ago, the European Molecular Biology Organization (EMBO) has been of invaluable help in meeting this challenge.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/scitech/biblio/22218288','SCIGOV-STC'); return false;" href="https://www.osti.gov/scitech/biblio/22218288"><span><span class="hlt">Big</span> bang nucleosynthesis: An update</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Olive, Keith A.</p> <p>2013-07-23</p> <p>An update on the standard model of <span class="hlt">big</span> bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <center> <div class="footer-extlink text-muted"><small>Some links on this page may take you to non-federal websites. 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