Single bumps in a 2-population homogenized neuronal network model

NASA Astrophysics Data System (ADS)

Kolodina, Karina; Oleynik, Anna; Wyller, John

2018-05-01

We investigate existence and stability of single bumps in a homogenized 2-population neural field model, when the firing rate functions are given by the Heaviside function. The model is derived by means of the two-scale convergence technique of Nguetseng in the case of periodic microvariation in the connectivity functions. The connectivity functions are periodically modulated in both the synaptic footprint and in the spatial scale. The bump solutions are constructed by using a pinning function technique for the case where the solutions are independent of the local variable. In the weakly modulated case the generic picture consists of two bumps (one narrow and one broad bump) for each admissible set of threshold values for firing. In addition, a new threshold value regime for existence of bumps is detected. Beyond the weakly modulated regime the number of bumps depends sensitively on the degree of heterogeneity. For the latter case we present a configuration consisting of three coexisting bumps. The linear stability of the bumps is studied by means of the spectral properties of a Fredholm integral operator, block diagonalization of this operator and the Fourier decomposition method. In the weakly modulated regime, one of the bumps is unstable for all relative inhibition times, while the other one is stable for small and moderate values of this parameter. The latter bump becomes unstable as the relative inhibition time exceeds a certain threshold. In the case of the three coexisting bumps detected in the regime of finite degree of heterogeneity, we have at least one stable bump (and maximum two stable bumps) for small and moderate values of the relative inhibition time.

Effects of PCB Pad Metal Finishes on the Cu-Pillar/Sn-Ag Micro Bump Joint Reliability of Chip-on-Board (COB) Assembly

NASA Astrophysics Data System (ADS)

Kim, Youngsoon; Lee, Seyong; Shin, Ji-won; Paik, Kyung-Wook

2016-06-01

While solder bumps have been used as the bump structure to form the interconnection during the last few decades, the continuing scaling down of devices has led to a change in the bump structure to Cu-pillar/Sn-Ag micro-bumps. Cu-pillar/Sn-Ag micro-bump interconnections differ from conventional solder bump interconnections in terms of their assembly processing and reliability. A thermo-compression bonding method with pre-applied b-stage non-conductive films has been adopted to form solder joints between Cu pillar/Sn-Ag micro bumps and printed circuit board vehicles, using various pad metal finishes. As a result, various interfacial inter-metallic compounds (IMCs) reactions and stress concentrations occur at the Cu pillar/Sn-Ag micro bumps joints. Therefore, it is necessary to investigate the influence of pad metal finishes on the structural reliability of fine pitch Cu pillar/Sn-Ag micro bumps flip chip packaging. In this study, four different pad surface finishes (Thin Ni ENEPIG, OSP, ENEPIG, ENIG) were evaluated in terms of their interconnection reliability by thermal cycle (T/C) test up to 2000 cycles at temperatures ranging from -55°C to 125°C and high-temperature storage test up to 1000 h at 150°C. The contact resistances of the Cu pillar/Sn-Ag micro bump showed significant differences after the T/C reliability test in the following order: thin Ni ENEPIG > OSP > ENEPIG where the thin Ni ENEPIG pad metal finish provided the best Cu pillar/Sn-Ag micro bump interconnection in terms of bump joint reliability. Various IMCs formed between the bump joint areas can account for the main failure mechanism.

Structural integrity of power generating speed bumps made of concrete foam composite

NASA Astrophysics Data System (ADS)

Syam, B.; Muttaqin, M.; Hastrino, D.; Sebayang, A.; Basuki, W. S.; Sabri, M.; Abda, S.

2018-02-01

In this paper concrete foam composite speed bumps were designed to generate electrical power by utilizing the movements of commuting vehicles on highways, streets, parking gates, and drive-thru station of fast food restaurants. The speed bumps were subjected to loadings generated by vehicles pass over the power generating mechanical system. In this paper, we mainly focus our discussion on the structural integrity of the speed bumps and discuss the electrical power generating speed bumps in another paper. One aspect of structural integrity is its ability to support designed loads without breaking and includes the study of past structural failures in order to prevent failures in future designs. The concrete foam composites were used for the speed bumps; the reinforcement materials are selected from empty fruit bunch of oil palm. In this study, the speed bump materials and structure were subjected to various tests to obtain its physical and mechanical properties. To analyze the structure stability of the speed bumps some models were produced and tested in our speed bump test station. We also conduct a FEM-based computer simulation to analyze stress responses of the speed bump structures. It was found that speed bump type 1 significantly reduced the radial voltage. In addition, the speed bump is equipped with a steel casing is also suitable for use as a component component in generating electrical energy.

Analysis of Power Generating Speed Bumps Made of Concrete Foam Composite

NASA Astrophysics Data System (ADS)

Syam, B.; Muttaqin, M.; Hastrino, D.; Sebayang, A.; Basuki, W. S.; Sabri, M.; Abda, S.

2017-03-01

This paper discusses the analysis of speed bump made of concrete foam composite which is used to generate electrical power. Speed bumps are designed to decelerate the speed of vehicles before passing through toll gates, public areas, or any other safety purposes. In Indonesia a speed bump should be designed in the accordance with KM Menhub 3 year 1994. In this research, the speed bump was manufactured with dimensions and geometry comply to the regulation mentioned above. Concrete foam composite speed bumps were used due to its light weight and relatively strong to receive vertical forces from the tyres of vehicles passing over the bumps. The reinforcement materials are processed from empty fruit bunch of oil palm. The materials were subjected to various tests to obtain its physical and mechanical properties. To analyze the structure stability of the speed bumps some models were analyzed using a FEM-based numerical softwares. It was obtained that the speed bumps coupled with polymeric composite bar (3 inches in diameter) are significantly reduce the radial stresses. In addition, the speed bumps equipped with polymeric composite casing or steel casing are also suitable for use as part of system components in producing electrical energy.

Computer analysis of flow perturbations generated by placement of choke bumps in a wind tunnel

NASA Technical Reports Server (NTRS)

Campbell, R. L.

1981-01-01

An inviscid analytical study was conducted to determine the upstream flow perturbations caused by placing choke bumps in a wind tunnel. A computer program based on the stream-tube curvature method was used to calculate the resulting flow fields for a nominal free-stream Mach number range of 0.6 to 0.9. The choke bump geometry was also varied to investigate the effect of bump shape on the disturbance produced. Results from the study indicate that a region of significant variation from the free-stream conditions exists upstream of the throat of the tunnel. The extent of the disturbance region was, as a rule, dependent on Mach number and the geometry of the choke bump. In general, the upstream disturbance distance decreased for increasing nominal free-stream Mach number and for decreasing length-to-height ratio of the bump. A polynomial-curve choke bump usually produced less of a disturbance than did a circular-arc bump and going to an axisymmetric configuration (modeling choke bumps on all the tunnel walls) generally resulted in a lower disturbance than with the corresponding two dimensional case.

Study of Electromigration-Induced Failures on Cu Pillar Bumps Joined to OSP and ENEPIG Substrates

NASA Astrophysics Data System (ADS)

Hsiao, Yu-Hsiang; Lin, Kwang-Lung; Lee, Chiu-Wen; Shao, Yu-Hsiu; Lai, Yi-Shao

2012-12-01

This work studies electromigration (EM)-induced failures on Cu pillar bumps joined to organic solderability preservative (OSP) on Cu substrates (OSP-bumps) and electroless Ni(P)/electroless Pd/immersion Au (ENEPIG) under bump metallurgy (UBM) on Cu substrates (ENEPIG-bumps). Two failure modes (Cu pad consumption and gap formation) were found with OSP-bumps, but only one failure mode (gap formation) was found with ENEPIG-bumps. The main interfacial compound layer was the Cu6Sn5 compound, which suffered significant EM-induced dissolution, eventually resulting in severe Cu pad consumption at the cathode side for OSP-bumps. A (Cu,Ni)6Sn5 layer with strong resistance to EM-induced dissolution exists at the joint interface when a nickel barrier layer is incorporated at the cathode side (Ni or ENEPIG), and these imbalanced atomic fluxes result in the voids and gap formation. OSP-bumps showed better lifetime results than ENEPIG-bumps for several current stressing conditions. The inverse Cu atomic flux ( J Cu,chem) which diffuses from the Cu pad to cathode side retards the formation of voids. The driving force for J Cu,chem comes from the difference in chemical potential between the (Cu,Ni)6Sn5 and Cu6Sn5 phases.

Recent Advances in Understanding the Reminiscence Bump: The Importance of Cues in Guiding Recall from Autobiographical Memory

PubMed Central

Koppel, Jonathan; Rubin, David C.

2016-01-01

The reminiscence bump is the increased proportion of autobiographical memories from youth and early adulthood observed in adults over 40. It is one of the most robust findings in autobiographical memory research. Although described as a single period of increased memories, a recent meta-analysis which reported the beginning and ending ages of the bump from individual studies found that different classes of cues produce distinct bumps that vary in size and temporal location. The bump obtained in response to cue words is both smaller and located earlier in the lifespan than the bump obtained when important memories are requested. The bump obtained in response to odor cues is even earlier. This variation in the size and location of the reminiscence bump argues for theories based primarily on retrieval rather than encoding and retention, which most current theories stress. Furthermore, it points to the need to develop theories of autobiographical memory that account for this flexibility in the memories retrieved. PMID:27141156

Non-independent quantum bumps in Limulus ventral nerve photoreceptors--a new insight in the light transduction mechanism.

PubMed

Nagy, K

1992-09-14

Single photon-induced transient currents, called quantum bumps were stimulated by short flashes in dark-adapted ventral nerve photoreceptors of Limulus. Flash intensities were set to activate 3 or more bumps. In most cases, current bumps were activated with a constant rate. The frequency of bump occurrence was between 9 and 17 Hz. Results show that consecutive bumps are not independent and that some of them are not activated by a photon. The periodic bump activation indicates a molecular mechanism which quantifies the transmitter release not only by a light quantum, but also by a late phase of the transduction cascade. A model is proposed, in which Ca2+ ions released from intracellular stores transiently block the further Ca2+ release by inositol trisphosphate in an all-or-none manner.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bauer, R.; Ebersberger, B.; Kupfer, C.

SnAg solder bump is one bump type which is used to replace eutectic SnPb bumps. In this work tests have been done to characterize the reliability properties of this bump type. Electromigration (EM) tests, which were accelerated by high current and high temperature and high temperature storage (HTS) tests were performed. It was found that the reliability properties are sensitive to the material combinations in the interconnect stack. The interconnect stack includes substrate pad, pad finish, bump, underbump metallization (UBM) and the chip pad. Therefore separate test groups for SnAg bumps on Cu substrate pads with organic solderability preservative (OSP)more » finish and the identical bumps on pads with Ni/Au finish were used. In this paper the reliability test results and the corresponding failure analysis are presented. Some explanations about the differences in formation of intermetallic compounds (IMCs) are given.« less

Precision Photometry of Long Period Variable Stars: Flares and Bumps in the Night (Poster abstract)

NASA Astrophysics Data System (ADS)

Mais, D.

2015-06-01

(Abstract only) Mira variable stars are a broad class of stars, which encompass spectroscopic classes of type M, S, and C. These stars are closely related in terms of their long term variability, position on the Hertzsprung-Russell diagram their intermediate mass (from ~0.8 to ~8 solar mass) and the fact that class M evolves into the S and C type stars as certain stages of shell burning around the core proceeds. Recently, evidence has accumulated to suggest that Mira variables may go through flare up stages which result in brightening on the order of several tenths of a magnitude or more and may last hours to days in length. Very little is known about these events, indeed it is not clear that these events are real. In order to address the reality of these events, we established an automated acquisition/analysis of a group of 108 Mira variables in order to obtain the densest coverage of the periods to better constrain the potential flare-ups. Telescope control scripts were put in place along with real time analysis. This allowed for unattended acquisition of data on every clear night, all night long, in the V, R, and I photometric bands. In addition, during the course of the night multiple determinations are often obtained for a given star. The light curves of many of the program stars show a Cepheid-like bump phenomenon, however these appear on the ascending part of the light curve. In general, these bumps appear in longer period Mira's (>350 days). Bumps are not obvious or easily seen in VISUAL data records, although slope changes during rising phase are seen in some cases. So far, greater than 100,000 magnitude determinations have been obtained, many closely spaced in time. This should help to further constrain the potential occurrences of flare-up events.

Method to Improve Indium Bump Bonding via Indium Oxide Removal Using a Multi-Step Plasma Process

NASA Technical Reports Server (NTRS)

Dickie, Matthew R. (Inventor); Nikzad, Shouleh (Inventor); Greer, H. Frank (Inventor); Jones, Todd J. (Inventor); Vasquez, Richard P. (Inventor); Hoenk, Michael E. (Inventor)

2012-01-01

A process for removing indium oxide from indium bumps in a flip-chip structure to reduce contact resistance, by a multi-step plasma treatment. A first plasma treatment of the indium bumps with an argon, methane and hydrogen plasma reduces indium oxide, and a second plasma treatment with an argon and hydrogen plasma removes residual organics. The multi-step plasma process for removing indium oxide from the indium bumps is more effective in reducing the oxide, and yet does not require the use of halogens, does not change the bump morphology, does not attack the bond pad material or under-bump metallization layers, and creates no new mechanisms for open circuits.

Temporal distribution of favourite books, movies, and records: differential encoding and re-sampling.

PubMed

Janssen, Steve M J; Chessa, Antonio G; Murre, Jaap M J

2007-10-01

The reminiscence bump is the effect that people recall more personal events from early adulthood than from childhood or adulthood. The bump has been examined extensively. However, the question of whether the bump is caused by differential encoding or re-sampling is still unanswered. To examine this issue, participants were asked to name their three favourite books, movies, and records. Furthermore,they were asked when they first encountered them. We compared the temporal distributions and found that they all showed recency effects and reminiscence bumps. The distribution of favourite books had the largest recency effect and the distribution of favourite records had the largest reminiscence bump. We can explain these results by the difference in rehearsal. Books are read two or three times, movies are watched more frequently, whereas records are listened to numerous times. The results suggest that differential encoding initially causes the reminiscence bump and that re-sampling increases the bump further.

A Metal Bump Bonding Method Using Ag Nanoparticles as Intermediate Layer

NASA Astrophysics Data System (ADS)

Fu, Weixin; Nimura, Masatsugu; Kasahara, Takashi; Mimatsu, Hayata; Okada, Akiko; Shoji, Shuichi; Ishizuka, Shugo; Mizuno, Jun

2015-11-01

The future development of low-temperature and low-pressure bonding technology is necessary for fine-pitch bump application. We propose a bump structure using Ag nanoparticles as an intermediate layer coated on a fine-pitch Cu pillar bump. The intermediate layer is prepared using an efficient and cost-saving squeegee-coating method followed by a 100°C baking process. This bump structure can be easily flattened before the bonding process, and the low-temperature sinterability of the nanoparticles is retained. The bonding experiment was successfully performed at 250°C and 39.8 MPa and the bonding strength was comparable to that achieved via other bonding technology utilizing metal particles or porous material as bump materials.

New Patterns of Activity in a Pair of Interacting Excitatory-Inhibitory Neural Fields

NASA Astrophysics Data System (ADS)

Folias, S. E.; Ermentrout, G. B.

2011-11-01

In this Letter, we study stationary bump solutions in a pair of interacting excitatory-inhibitory (E-I) neural fields in one dimension. We demonstrate the existence of localized bump solutions of persistent activity that can be maintained by the pair of interacting layers when a stationary bump is not supported by either layer in isolation—a scenario which may be relevant as a mechanism for the persistent activity associated with working memory in the prefrontal cortex and may explain why bumps are not seen in in vitro slice preparations. Furthermore, we describe a new type of stationary bump solution arising from a pitchfork bifurcation which produces a stationary bump in each layer with a spatial offset that increases with the bifurcation parameter.

Autoassociative memory retrieval and spontaneous activity bumps in small-world networks of integrate-and-fire neurons.

PubMed

Anishchenko, Anastasia; Treves, Alessandro

2006-10-01

The metric structure of synaptic connections is obviously an important factor in shaping the properties of neural networks, in particular the capacity to retrieve memories, with which are endowed autoassociative nets operating via attractor dynamics. Qualitatively, some real networks in the brain could be characterized as 'small worlds', in the sense that the structure of their connections is intermediate between the extremes of an orderly geometric arrangement and of a geometry-independent random mesh. Small worlds can be defined more precisely in terms of their mean path length and clustering coefficient; but is such a precise description useful for a better understanding of how the type of connectivity affects memory retrieval? We have simulated an autoassociative memory network of integrate-and-fire units, positioned on a ring, with the network connectivity varied parametrically between ordered and random. We find that the network retrieves previously stored memory patterns when the connectivity is close to random, and displays the characteristic behavior of ordered nets (localized 'bumps' of activity) when the connectivity is close to ordered. Recent analytical work shows that these two behaviors can coexist in a network of simple threshold-linear units, leading to localized retrieval states. We find that they tend to be mutually exclusive behaviors, however, with our integrate-and-fire units. Moreover, the transition between the two occurs for values of the connectivity parameter which are not simply related to the notion of small worlds.

On the persistence of unstable bump-on-tail electron velocity distributions in the earth's foreshock

NASA Technical Reports Server (NTRS)

Klimas, Alexander J.; Fitzenreiter, Richard J.

1988-01-01

This paper presents further evidence for the persistence of bump-on-tail unstable reduced velocity distributions in the earth's electron foreshock, which contradicts the understanding of quasi-linear saturation of the bump-on-tail instability. A modified theory for the saturation of the bump-on-tail instability in the earth's foreshock is proposed to explain the mechanism of this persistence, and the predictions are compared to the results of a numerical simulation of the electron plasma in the foreshock. The results support the thesis that quasi-linear saturation of the bump-on-tail instability is modified in the foreshock, due to the driven nature of the region, so that at saturation the stabilized velocity distribution still appears bump-on-tail unstable to linear plasma analysis.

Salvaged castings and methods of salvaging castings with defective cast cooling bumps

DOEpatents

Johnson, Robert Alan; Schaeffer, Jon Conrad; Lee, Ching-Pang; Abuaf, Nesim; Hasz, Wayne Charles

2002-01-01

Castings for gas turbine parts exposed on one side to a high-temperature fluid medium have cast-in bumps on an opposite cooling surface side to enhance heat transfer. Areas on the cooling surface having defectively cast bumps, i.e., missing or partially formed bumps during casting, are coated with a braze alloy and cooling enhancement material to salvage the part.

Bump Bonding Using Metal-Coated Carbon Nanotubes

NASA Technical Reports Server (NTRS)

Lamb, James L.; Dickie, Matthew R.; Kowalczyk, Robert S.; Liao, Anna; Bronikowski, Michael J.

2012-01-01

Bump bonding hybridization techniques use arrays of indium bumps to electrically and mechanically join two chips together. Surface-tension issues limit bump sizes to roughly as wide as they are high. Pitches are limited to 50 microns with bumps only 8-14 microns high on each wafer. A new process uses oriented carbon nanotubes (CNTs) with a metal (indium) in a wicking process using capillary actions to increase the aspect ratio and pitch density of the connections for bump bonding hybridizations. It merges the properties of the CNTs and the metal bumps, providing enhanced material performance parameters. By merging the bumps with narrow and long CNTs oriented in the vertical direction, higher aspect ratios can be obtained if the metal can be made to wick. Possible aspect ratios increase from 1:1 to 20:1 for most applications, and to 100:1 for some applications. Possible pitch density increases of a factor of 10 are possible. Standard capillary theory would not normally allow indium or most other metals to be drawn into the oriented CNTs, because they are non-wetting. However, capillary action can be induced through the ability to fabricate oriented CNT bundles to desired spacings, and the use of deposition techniques and temperature to control the size and mobility of the liquid metal streams and associated reservoirs. This hybridization of two technologies (indium bumps and CNTs) may also provide for some additional benefits such as improved thermal management and possible current density increases.

Electromigration kinetics and critical current of Pb-free interconnects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Minhua; Rosenberg, Robert

2014-04-07

Electromigration kinetics of Pb-free solder bump interconnects have been studied using a single bump parameter sweep technique. By removing bump to bump variations in structure, texture, and composition, the single bump sweep technique has provided both activation energy and power exponents that reflect atomic migration and interface reactions with fewer samples, shorter stress time, and better statistics than standard failure testing procedures. Contact metallurgies based on Cu and Ni have been studied. Critical current, which corresponds to the Blech limit, was found to exist in the Ni metallurgy, but not in the Cu metallurgy. A temperature dependence of critical currentmore » was also observed.« less

Enhanced heat transfer surface for cast-in-bump-covered cooling surfaces and methods of enhancing heat transfer

DOEpatents

Chiu, Rong-Shi Paul; Hasz, Wayne Charles; Johnson, Robert Alan; Lee, Ching-Pang; Abuaf, Nesim

2002-01-01

An annular turbine shroud separates a hot gas path from a cooling plenum containing a cooling medium. Bumps are cast in the surface on the cooling side of the shroud. A surface coating overlies the cooling side surface of the shroud, including the bumps, and contains cooling enhancement material. The surface area ratio of the cooling side of the shroud with the bumps and coating is in excess of a surface area ratio of the cooling side surface with bumps without the coating to afford increased heat transfer across the element relative to the heat transfer across the element without the coating.

Cell responses to single pheromone molecules may reflect the activation kinetics of olfactory receptor molecules.

PubMed

Minor, A V; Kaissling, K-E

2003-03-01

Olfactory receptor cells of the silkmoth Bombyx mori respond to single pheromone molecules with "elementary" electrical events that appear as discrete "bumps" a few milliseconds in duration, or bursts of bumps. As revealed by simulation, one bump may result from a series of random openings of one or several ion channels, producing an average inward membrane current of 1.5 pA. The distributions of durations of bumps and of gaps between bumps in a burst can be fitted by single exponentials with time constants of 10.2 ms and 40.5 ms, respectively. The distribution of burst durations is a sum of two exponentials; the number of bumps per burst obeyed a geometric distribution (mean 3.2 bumps per burst). Accordingly the elementary events could reflect transitions among three states of the pheromone receptor molecule: the vacant receptor (state 1), the pheromone-receptor complex (state 2), and the activated complex (state 3). The calculated rate constants of the transitions between states are k(21)=7.7 s(-1), k(23)=16.8 s(-1), and k(32)=98 s(-1).

Laser-induced forward transfer for flip-chip packaging of single dies.

PubMed

Kaur, Kamal S; Van Steenberge, Geert

2015-03-20

Flip-chip (FC) packaging is a key technology for realizing high performance, ultra-miniaturized and high-density circuits in the micro-electronics industry. In this technique the chip and/or the substrate is bumped and the two are bonded via these conductive bumps. Many bumping techniques have been developed and intensively investigated since the introduction of the FC technology in 1960(1) such as stencil printing, stud bumping, evaporation and electroless/electroplating2. Despite the progress that these methods have made they all suffer from one or more than one drawbacks that need to be addressed such as cost, complex processing steps, high processing temperatures, manufacturing time and most importantly the lack of flexibility. In this paper, we demonstrate a simple and cost-effective laser-based bump forming technique known as Laser-induced Forward Transfer (LIFT)3. Using the LIFT technique a wide range of bump materials can be printed in a single-step with great flexibility, high speed and accuracy at RT. In addition, LIFT enables the bumping and bonding down to chip-scale, which is critical for fabricating ultra-miniature circuitry.

Phospholipase C mediated Suppression of Dark Noise Enables Single Photon Detection in Drosophila Photoreceptors

PubMed Central

Katz, Ben; Minke, Baruch

2012-01-01

Drosophila photoreceptor cells use the ubiquitous G-protein-mediated phospholipase C (PLC) cascade to achieve ultimate single photon sensitivity. This is manifested in the single photon responses (quantum bumps). In photoreceptor cells, dark activation of Gqα molecules occurs spontaneously and produces unitary dark events (dark bumps). A high rate of spontaneous Gqα activation and dark bump production potentially hampers single photon detection. We found that in wild type flies the in vivo rate of spontaneous Gqα activation is very high. Nevertheless, this high rate is not manifested in a substantially high rate of dark bumps. Therefore, it is unclear how phototransduction suppresses dark bump production, arising from spontaneous Gqα activation, while still maintaining high-fidelity representation of single photons. In this study we show that reduced PLC catalytic activity selectively suppressed production of dark bumps but not light-induced bumps. Manipulations of PLC activity using PLC mutant flies and Ca2+ modulations revealed that a critical level of PLC activity is required to induce bump production. The required minimal level of PLC activity, selectively suppressed random production of single Gqα-activated dark bumps despite a high rate of spontaneous Gqα activation. This minimal PLC activity level is reliably obtained by photon induced synchronized activation of several neighboring Gqα molecules activating several PLC molecules, but not by random activation of single Gqα molecules. We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling. PMID:22357856

Effect of wettability and topological features of Namib beetle inspired bumps on dropwise condensation

NASA Astrophysics Data System (ADS)

Ahmad, Shakeel; Tang, Hui; Yao, Haimin

2017-11-01

The Stenocara beetle lives in arid desert environment where the only available source of water is fog droplets. The beetle contains many hydrophobic/hydrophilic bumps on its back. Water collection occurs on the hydrophilic patches. Once the droplet reaches the critical volume, it sheds down due to gravity. Although a number of studies on condensation and water collection on beetle inspired structures have been reported in literature, most of them were on micro/nano scale textures. However, in nature the beetle bumps are in millimeter scale. At this scale the role of topological features and gravity becomes crucial for early droplet shedding. Therefore, in this work we numerically investigated the effects of bump shape, wettability contrast, surface slope and hydrophilic patch to total area ratio on droplet shedding volume and time. A three-dimensional lattice Boltzmann method (LBM) based numerical framework was used for the simulations. Compared with bumps of other shapes such a cube or a circular cylinder, faster droplet shedding was obtained over a hemispherical bump. Furthermore, it was found that larger hydrophilic patch to total area ratio for the hemispherical bump significantly increased the droplet shedding time.

The Effects of Extravehicular Activity (EVA) Glove Pressure on Tactility

NASA Technical Reports Server (NTRS)

Thompson, Shelby; Miranda, Mesloh; England, Scott; Benson, Elizabeth; Rajulu, Sudhakar

2010-01-01

The purpose of the current study was to quantify finger tactility, while wearing a Phase VI Extravehicular Activity (EVA) glove. Subjects were fully suited in an Extravehicular Mobility Unit (EMU) suit. Data was collected under three conditions: bare-handed, gloved at 0 psi, and gloved at 4.3 psi. In order to test tactility, a series of 30 tactile stimuli (bumps) were created that varied in both height and width. With the hand obscured, subjects applied pressure to each bump until detected tactilely. The amount of force needed to detect each bump was recorded using load cells located under a force-plate. The amount of force needed to detect a bump was positively related to width, but inversely related to height. In addition, as the psi of the glove increased, more force was needed to detect the bump. In terms of application, it was possible to determine the optimal width and height a bump needs to be for a specific amount of force applied for tactility.

On the Application of Contour Bumps for Transonic Drag Reduction(Invited)

NASA Technical Reports Server (NTRS)

Milholen, William E., II; Owens, Lewis R.

2005-01-01

The effect of discrete contour bumps on reducing the transonic drag at off-design conditions on an airfoil have been examined. The research focused on fully-turbulent flow conditions, at a realistic flight chord Reynolds number of 30 million. State-of-the-art computational fluid dynamics methods were used to design a new baseline airfoil, and a family of fixed contour bumps. The new configurations were experimentally evaluated in the 0.3-m Transonic Cryogenic Tunnel at the NASA Langley Research center, which utilizes an adaptive wall test section to minimize wall interference. The computational study showed that transonic drag reduction, on the order of 12% - 15%, was possible using a surface contour bump to spread a normal shock wave. The computational study also indicated that the divergence drag Mach number was increased for the contour bump applications. Preliminary analysis of the experimental data showed a similar contour bump effect, but this data needed to be further analyzed for residual wall interference corrections.

Body-terrain interaction affects large bump traversal of insects and legged robots.

PubMed

Gart, Sean W; Li, Chen

2018-02-02

Small animals and robots must often rapidly traverse large bump-like obstacles when moving through complex 3D terrains, during which, in addition to leg-ground contact, their body inevitably comes into physical contact with the obstacles. However, we know little about the performance limits of large bump traversal and how body-terrain interaction affects traversal. To address these, we challenged the discoid cockroach and an open-loop six-legged robot to dynamically run into a large bump of varying height to discover the maximal traversal performance, and studied how locomotor modes and traversal performance are affected by body-terrain interaction. Remarkably, during rapid running, both the animal and the robot were capable of dynamically traversing a bump much higher than its hip height (up to 4 times the hip height for the animal and 3 times for the robot, respectively) at traversal speeds typical of running, with decreasing traversal probability with increasing bump height. A stability analysis using a novel locomotion energy landscape model explained why traversal was more likely when the animal or robot approached the bump with a low initial body yaw and a high initial body pitch, and why deflection was more likely otherwise. Inspired by these principles, we demonstrated a novel control strategy of active body pitching that increased the robot's maximal traversable bump height by 75%. Our study is a major step in establishing the framework of locomotion energy landscapes to understand locomotion in complex 3D terrains.

Spacetime and orbits of bumpy black holes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vigeland, Sarah J.; Hughes, Scott A.

2010-01-15

Our Universe contains a great number of extremely compact and massive objects which are generally accepted to be black holes. Precise observations of orbital motion near candidate black holes have the potential to determine if they have the spacetime structure that general relativity demands. As a means of formulating measurements to test the black hole nature of these objects, Collins and Hughes introduced ''bumpy black holes'': objects that are almost, but not quite, general relativity's black holes. The spacetimes of these objects have multipoles that deviate slightly from the black hole solution, reducing to black holes when the deviation ismore » zero. In this paper, we extend this work in two ways. First, we show how to introduce bumps which are smoother and lead to better behaved orbits than those in the original presentation. Second, we show how to make bumpy Kerr black holes--objects which reduce to the Kerr solution when the deviation goes to zero. This greatly extends the astrophysical applicability of bumpy black holes. Using Hamilton-Jacobi techniques, we show how a spacetime's bumps are imprinted on orbital frequencies, and thus can be determined by measurements which coherently track the orbital phase of a small orbiting body. We find that in the weak field, orbits of bumpy black holes are modified exactly as expected from a Newtonian analysis of a body with a prescribed multipolar structure, reproducing well-known results from the celestial mechanics literature. The impact of bumps on strong-field orbits is many times greater than would be predicted from a Newtonian analysis, suggesting that this framework will allow observations to set robust limits on the extent to which a spacetime's multipoles deviate from the black hole expectation.« less

Low-stress soldering technique used to assemble an optical system for aerospace missions

NASA Astrophysics Data System (ADS)

Ribes-Pleguezuelo, P.; Koechlin, C.; Burkhardt, T.; Hornaff, M.; Kamm, A.; Gramens, S.; Beckert, E.; Fiault, G.; Eberhardt, R.; Tünnermann, A.

2017-09-01

A high-precision opto-mechanical breadboard for a lens mount has been assembled by means of a laserbased soldering process called Solderjet Bumping; which thanks to its localized and minimized input of thermal energy, is well suited for the joining of optical components made of fragile and brittle materials such as glasses. An optical element made of a silica lens and a titanium barrel has been studied to replicate the lens mounts of the afocal beam expander used in the LIDAR instrument (ATLID) of the ESA EarthCare Mission, whose aim is to monitor molecular and particle-based back-scattering in order to analyze atmosphere composition. Finally, a beam expander optical element breadboard with a silica lens and a titanium barrel was assembled using the Solderjet Bumping technology with Sn96.5Ag3Cu0.5 SAC305 alloy resulting in a low residual stress (<1 MPa) on the joining areas, a low light-depolarization (<0.2 %) and low distortion (wave-front error measurement < 5 nm rms) on the assemblies. The devices also successfully passed humidity, thermal-vacuum, vibration, and shock tests with conditions similar to the ones expected for the ESA EarthCare mission and without altering their optical performances.

How bumps on whale flippers delay stall: an aerodynamic model.

PubMed

van Nierop, Ernst A; Alben, Silas; Brenner, Michael P

2008-02-08

Wind tunnel experiments have shown that bumps on the leading edge of model humpback whale flippers cause them to "stall" (i.e., lose lift dramatically) more gradually and at a higher angle of attack. Here we develop an aerodynamic model which explains the observed increase in stall angle. The model predicts that as the amplitude of the bumps is increased, the lift curve flattens out, leading to potentially desirable control properties. We find that stall delay is insensitive to the wavelength of the bumps, in accordance with experimental observations.

Thermal cycling reliability of Cu/SnAg double-bump flip chip assemblies for 100 μm pitch applications

NASA Astrophysics Data System (ADS)

Son, Ho-Young; Kim, Ilho; Lee, Soon-Bok; Jung, Gi-Jo; Park, Byung-Jin; Paik, Kyung-Wook

2009-01-01

A thick Cu column based double-bump flip chip structure is one of the promising alternatives for fine pitch flip chip applications. In this study, the thermal cycling (T/C) reliability of Cu/SnAg double-bump flip chip assemblies was investigated, and the failure mechanism was analyzed through the correlation of T/C test and the finite element analysis (FEA) results. After 1000 thermal cycles, T/C failures occurred at some Cu/SnAg bumps located at the edge and corner of chips. Scanning acoustic microscope analysis and scanning electron microscope observations indicated that the failure site was the Cu column/Si chip interface. It was identified by a FEA where the maximum stress concentration was located during T/C. During T/C, the Al pad between the Si chip and a Cu column bump was displaced due to thermomechanical stress. Based on the low cycle fatigue model, the accumulation of equivalent plastic strain resulted in thermal fatigue deformation of the Cu column bumps and ultimately reduced the thermal cycling lifetime. The maximum equivalent plastic strains of some bumps at the chip edge increased with an increased number of thermal cycles. However, equivalent plastic strains of the inner bumps did not increase regardless of the number of thermal cycles. In addition, the z-directional normal plastic strain ɛ22 was determined to be compressive and was a dominant component causing the plastic deformation of Cu/SnAg double bumps. As the number of thermal cycles increased, normal plastic strains in the perpendicular direction to the Si chip and shear strains were accumulated on the Cu column bumps at the chip edge at low temperature region. Thus it was found that the Al pad at the Si chip/Cu column interface underwent thermal fatigue deformation by compressive normal strain and the contact loss by displacement failure of the Al pad, the main T/C failure mode of the Cu/SnAg flip chip assembly, then occurred at the Si chip/Cu column interface shear strain deformation during T/C.

Leveling up the analysis of the reminiscence bump in autobiographical memory: A new approach based on multilevel multinomial models.

PubMed

Zimprich, Daniel; Wolf, Tabea

2018-06-20

In many studies of autobiographical memory, participants are asked to generate more than one autobiographical memory. The resulting data then have a hierarchical or multilevel structure, in the sense that the autobiographical memories (Level 1) generated by the same person (Level 2) tend to be more similar. Transferred to an analysis of the reminiscence bump in autobiographical memory, at Level 1 the prediction of whether an autobiographical memory will fall within the reminiscence bump is based on the characteristics of that memory. At Level 2, the prediction of whether an individual will report more autobiographical memories that fall in the reminiscence bump is based on the characteristics of the individual. We suggest a multilevel multinomial model that allows for analyzing whether an autobiographical memory falls in the reminiscence bump at both levels of analysis simultaneously. The data come from 100 older participants who reported up to 33 autobiographical memories. Our results showed that about 12% of the total variance was between persons (Level 2). Moreover, at Level 1, memories of first-time experiences were more likely to fall in the reminiscence bump than were emotionally more positive memories. At Level 2, persons who reported more emotionally positive memories tended to report fewer memories from the life period after the reminiscence bump. In addition, cross-level interactions showed that the effects at Level 1 partly depended on the Level 2 effects. We discuss possible extensions of the model we present and the meaning of our findings for two prominent explanatory approaches to the reminiscence bump, as well as future directions.

A 90 GHz Amplifier Assembled Using a Bump-Bonded InP-Based HEMT

NASA Technical Reports Server (NTRS)

Pinsukanjana, Paul R.; Samoska, Lorene A.; Gaier, Todd C.; Smith, R. Peter; Ksendzov, Alexander; Fitzsimmons, Michael J.; Martin, Suzanne C.

1998-01-01

We report on the performance of a novel W-band amplifier fabricated utilizing very compact bump bonds. We bump-bonded a high-speed, low-noise InP high electron mobility transistor (HEMT) onto a separately fabricated passive circuit having a GaAs substrate. The compact bumps and small chip size were used for efficient coupling and maximum circuit design flexibility. This new quasi-monolithic millimeter-wave integrated circuit (Q-MMIC) amplifier exhibits a peak gain of 5.8 dB at approx. 90 GHz and a 3 dB bandwidth of greater than 25%. To our knowledge, this is the highest frequency amplifier assembled using bump-bonded technology. Our bump-bonding technique is a useful alternative to the high cost of monolithic millimeter-wave integrated circuits (MMIC's). Effects of the bumps on the circuit appear to be minimal. We used the simple matching circuit for demonstrating the technology - future circuits would have all of the elements (resistors, via holes, bias lines, etc.) included 'in conventional MMIC's. Our design in different from other investigators' efforts in that the bumps are only 8 microns thick by 15 microns wide. The bump sizes were sufficiently small that the devices, originally designed for W-band hybrid circuits, could be bonded without alteration. Figure 3 shows the measured and simulated magnitude of S-parameters from 85-120 GHz, of the InP HEMT bump-bonded to the low noise amplifier (LNA) passive. The maximum gain is 5.8 dB at approx. 90 GHz, and gain extends to 117 GHz. Measurement of a single device (without matching networks) shows approx. 1 dB of gain at 90 GHz. The measured gain of the amplifier agrees well with the design in the center of the measurement band, and the agreement falls off at the band edges. Since no accommodation for the bump-bonding parasitics was made in the design, the result implies that the parasitic elements associated with the bonding itself do not dominate the performance of the LNA circuit. It should be noted that this amplifier was designed for good noise performance, which is why the input and output return losses are poorer than one would expect for an amplifier simply matched for gain. However, noise performance has not been measured at this time. While the agreement between modeled vs. experimental data is not exact, the data prove that bump-bonded technology can be used for amplifiers at frequencies at least as high as 100 GHz. JPL is pursuing this technology as a way to economically and quickly incorporate the best available HEMTs into a circuit with all of the reliability and circuit design flexibility offered by MMIC technology. We are currently using the technology to fabricate 4-stage, wide-band, W-band LNA's. We have also performed pull and shear tests which show that the bump bonds are sufficiently robust for any anticipated application.

The Physics of Bump Drafting in Car Racing

ERIC Educational Resources Information Center

Fiolhais, Miguel C. N.; Amor dos Santos, Susana

2014-01-01

The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

Two-Step Plasma Process for Cleaning Indium Bonding Bumps

NASA Technical Reports Server (NTRS)

Greer, Harold F.; Vasquez, Richard P.; Jones, Todd J.; Hoenk, Michael E.; Dickie, Matthew R.; Nikzad, Shouleh

2009-01-01

A two-step plasma process has been developed as a means of removing surface oxide layers from indium bumps used in flip-chip hybridization (bump bonding) of integrated circuits. The two-step plasma process makes it possible to remove surface indium oxide, without incurring the adverse effects of the acid etching process.

Life scripts for emotionally charged autobiographical memories: A cultural explanation of the reminiscence bump.

PubMed

Haque, Shamsul; Hasking, Penelope A

2010-10-01

Two studies examined the ability of the life script account to explain the reminiscence bump for emotionally charged autobiographical memories among Malaysian participants. In Study 1 volunteers, aged 50-90 years, participated in a two-phased task. In the first phase, participants estimated the timing of 11 life events (both positive and negative) that may occur in a prototypical life course within their own culture. Two weeks later the participants retrieved the same set of events from their lives and reported how old they were when those events occurred. In the second study 92 undergraduate students produced life scripts for the same 11 events. The findings revealed reminiscence bumps in both life script and retrieval curves for the memories judged happiest, most important, most in love, and most jealous. A reminiscence bump was also noted for success, although this was later in the lifespan than other reminiscence bumps. It was suggested that the life scripts can be used as an alternative account for the reminiscence bump, for highly positive and occasionally for negative autobiographical memories.

Fission gas release during power bumping at high burnup

NASA Astrophysics Data System (ADS)

Cunningham, M. E.; Freshley, M. D.; Lanning, D. D.

1993-03-01

Research to define the behavior of Zircaloy-clad light-water reactor fuel irradiated to high burnup levels was conducted by the High Burnup Effects Program (HBEP). One activity conducted by the HBEP was to "bump" the power level of irradiated, commercial light-water reactor fuel rods to design limit linear heat generation rates at end-of-life. These bumping irradiations simulated end-of-life design limit linear heat generation rates and provided data on the effects of short-term, high power irradiations at high burnup applicable to the design and operating constraints imposed by maximum allowable fuel rod internal gas pressure limits. Based on net fission gas release during the bumping irradiations, it was observed that higher burnup rods had greater rod-average fractional fission gas release than lower burnup rods at equal bumping powers. It was also observed that a hold period of 48 hours at the peak power was insufficient to achieve equilibrium fission gas release. Finally, differences in the prebump location of fission gas, i.e., within the UO 2 matrix or at grain boundaries, affected the fission gas release during the bumping irradiations.

Effect of Grain Boundary Misorientation on Electromigration in Lead-Free Solder Joints

NASA Astrophysics Data System (ADS)

Tasooji, Amaneh; Lara, Leticia; Lee, Kyuoh

2014-12-01

Reduction in microelectronic interconnect size gives rise to solder bumps consisting of few grains, approaching a single- or bicrystal grain morphology in C4 bumps. Single grain anisotropy, individual grain orientation, presence of easy diffusion paths along grain boundaries, and the increased current density in these small solder bumps aggravate electromigration. This reduces the reliability of the entire microelectronic system. This paper focuses on electromigration behavior in Pb-free solder, specifically the Sn-0.7 wt.%Cu alloy. We discuss the effects of texture, grain orientation, and grain boundary misorientation angle on electromigration (EM) and intermetallic compound formation in EM-tested C4 bumps. The detailed electron backscatter diffraction (EBSD) analysis used in this study reveals the greater influence of grain boundary misorientation on solder bump electromigration compared with the effect associated with individual grain orientation.

Evaluation of advanced microelectronic fluxless solder-bump contacts for hybrid microcircuits

NASA Technical Reports Server (NTRS)

Mandal, R. P.

1976-01-01

Technology for interconnecting monolithic integrated circuit chips with other components is investigated. The advantages and disadvantages of the current flip-chip approach as compared to other interconnection methods are outlined. A fluxless solder-bump contact technology is evaluated. Multiple solder-bump contacts were formed on silicon integrated circuit chips. The solder-bumps, comprised of a rigid nickel under layer and a compliant solder overlayer, were electroformed onto gold device pads with the aid of thick dry film photomasks. Different solder alloys and the use of conductive epoxy for bonding were explored. Fluxless solder-bump bond quality and reliability were evaluated by measuring the effects of centrifuge, thermal cycling, and high temperature storage on bond visual characteristics, bond electrical continuity, and bond shear tests. The applicability and suitability of this technology for hybrid microelectronic packaging is discussed.

Manipulation of the micro and macro-structure of beams extracted from cyclotrons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laxdal, R.E.

1995-09-01

It is standard practice in cyclotrons to alter the extracted micro-pulse width by using center-region slits and/or by chopping the beam before injection. The macro-structure can also be varied by means of pulsed or sinusoidal deflection devices before injection and/or after extraction. All above methods, however, involve cutting away the unwanted beam, thus reducing the time-averaged intensity. This paper will focus on some methods used to alter the time structure of extracted beams without significant beam loss. For example radial gradients in the accelerating fields from rf cavities can be utilized to compress, expand or even split longitudinally the circulatingmore » particle bunches. The macro-structure of the extracted beam can be altered by employing resonant extraction methods and replacing the static magnetic bump with either a pulsed or a sinusoidal transverse perturbation. The methods are most suitable for H cyclotrons but may also be considered in a limited scope for cyclotrons using direct extraction. Results of computer simulations and beam tests on the TRIUMF 500 MeV H{sup {minus}} cyclotron will be presented.« less

Bumping into Someone: Japanese Students' Perceptions and Observations

ERIC Educational Resources Information Center

Lieske, Carmella

2010-01-01

This pilot study explores the apologies Japanese nursing college students thought they would use in their L1 (i.e. Japanese) and their L2 (i.e. English) when bumping into each other. The students completed a questionnaire, the results of which indicated that they believed they should always apologize for bumping into someone. The paper describes…

Structural Joint with Multi-Axis Load Carrying Capability

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey (Inventor); Martin, Robert A. (Inventor); Stewart, Brian K. (Inventor)

2017-01-01

A structural joint is formed of a mandrel having a plurality of bumps and dimples formed thereon which is fitted into a sleeve. The bumps and dimples form a non-circular geometry at all points along the length of the mandrel. The bumps are defined by surfaces which have 1st and 2nd derivatives which are continuous.

Harmonic engine

DOEpatents

Bennett, Charles L.; Sewall, Noel; Boroa, Carl

2014-08-19

An engine based on a reciprocating piston engine that extracts work from pressurized working fluid. The engine includes a harmonic oscillator inlet valve capable of oscillating at a resonant frequency for controlling the flow of working fluid into of the engine. In particular, the inlet valve includes an inlet valve head and a spring arranged together as a harmonic oscillator so that the inlet valve head is moveable from an unbiased equilibrium position to a biased closed position occluding an inlet. Upon releasing the inlet valve the inlet valve head undergoes a single oscillation past the equilibrium positio to a maximum open position and returns to a biased return position close to the closed position to choke the flow and produce a pressure drop across the inlet valve causing the inlet valve to close. Protrusions carried either by the inlet valve head or piston head are used to bump open the inlet valve from the closed position and initiate the single oscillation of the inlet valve head, and protrusions carried either by the outlet valve head or piston head are used to close the outlet valve ahead of the bump opening of the inlet valve.

The 1600 Å Emission Bump in Protoplanetary Disks: A Spectral Signature of H{sub 2}O Dissociation

DOE Office of Scientific and Technical Information (OSTI.GOV)

France, Kevin; Roueff, Evelyne; Abgrall, Hervé, E-mail: kevin.france@colorado.edu

The FUV continuum spectrum of many accreting pre-main sequence stars, Classical T Tauri Stars (CTTSs), does not continue smoothly from the well-studied Balmer continuum emission in the NUV, suggesting that additional processes contribute to the short-wavelength emission in these objects. The most notable spectral feature in the FUV continuum of some CTTSs is a broad emission approximately centered at 1600 Å, which has been referred to as the “1600 Å Bump.” The origin of this feature remains unclear. In an effort to better understand the molecular properties of planet-forming disks and the UV spectral properties of accreting protostars, we havemore » assembled archival FUV spectra of 37 disk-hosting systems observed by the Hubble Space Telescope -Cosmic Origins Spectrograph. Clear 1600 Å Bump emission is observed above the smooth, underlying 1100–1800 Å continuum spectrum in 19/37 Classical T Tauri disks in the HST -COS sample, with the detection rate in transition disks (8/8) being much higher than that in primordial or non-transition sources (11/29). We describe a spectral deconvolution analysis to separate the Bump (spanning 1490–1690 Å) from the underlying FUV continuum, finding an average Bump luminosity L (Bump) ≈ 7 × 10{sup 29} erg s{sup −1}. Parameterizing the Bump with a combination of Gaussian and polynomial components, we find that the 1600 Å Bump is characterized by a peak wavelength λ {sub o} = 1598.6 ± 3.3 Å, with FWHM = 35.8 ± 19.1 Å. Contrary to previous studies, we find that this feature is inconsistent with models of H{sub 2} excited by electron -impact. We show that this Bump makes up between 5%–50% of the total FUV continuum emission in the 1490–1690 Å band and emits roughly 10%–80% of the total fluorescent H{sub 2} luminosity for stars with well-defined Bump features. Energetically, this suggests that the carrier of the 1600 Å Bump emission is powered by Ly α photons. We argue that the most likely mechanism is Ly α -driven dissociation of H{sub 2}O in the inner disk, r ≲ 2 au. We demonstrate that non-thermally populated H{sub 2}O fragments can qualitatively account for the observed emission (discrete and continuum) and find that the average Ly α -driven H{sub 2}O dissociation rate is 1.7 × 10{sup 42} water molecules s{sup −1}.« less

Precision enhancement of pavement roughness localization with connected vehicles

NASA Astrophysics Data System (ADS)

Bridgelall, R.; Huang, Y.; Zhang, Z.; Deng, F.

2016-02-01

Transportation agencies rely on the accurate localization and reporting of roadway anomalies that could pose serious hazards to the traveling public. However, the cost and technical limitations of present methods prevent their scaling to all roadways. Connected vehicles with on-board accelerometers and conventional geospatial position receivers offer an attractive alternative because of their potential to monitor all roadways in real-time. The conventional global positioning system is ubiquitous and essentially free to use but it produces impractically large position errors. This study evaluated the improvement in precision achievable by augmenting the conventional geo-fence system with a standard speed bump or an existing anomaly at a pre-determined position to establish a reference inertial marker. The speed sensor subsequently generates position tags for the remaining inertial samples by computing their path distances relative to the reference position. The error model and a case study using smartphones to emulate connected vehicles revealed that the precision in localization improves from tens of metres to sub-centimetre levels, and the accuracy of measuring localized roughness more than doubles. The research results demonstrate that transportation agencies will benefit from using the connected vehicle method to achieve precision and accuracy levels that are comparable to existing laser-based inertial profilers.

Revisiting the emission from relativistic blast waves in a density-jump medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geng, J. J.; Huang, Y. F.; Dai, Z. G.

2014-09-01

Re-brightening bumps are frequently observed in gamma-ray burst afterglows. Many scenarios have been proposed to interpret the origin of these bumps, of which a blast wave encountering a density-jump in the circumburst environment has been questioned by recent works. We develop a set of differential equations to calculate the relativistic outflow encountering the density-jump by extending the work of Huang et al. This approach is a semi-analytic method and is very convenient. Our results show that late high-amplitude bumps cannot be produced under common conditions, rather only a short plateau may emerge even when the encounter occurs at an earlymore » time (<10{sup 4} s). In general, our results disfavor the density-jump origin for those observed bumps, which is consistent with the conclusion drawn from full hydrodynamics studies. The bumps thus should be caused by other scenarios.« less

An experimental and theoretical study of structural damping in compliant foil bearings

NASA Technical Reports Server (NTRS)

Ku, C.-P. Roger

1994-01-01

This paper describes an experimental investigation into the dynamic characteristics of corrugated foil (bump foil) strips used in compliant surface foil bearings. This study provided and opportunity to quantify the structural damping of bump foil strips. The experimental data were compared to results obtained by a theoretical model developed earlier. The effects of bearing design parameters, such as static loads, dynamic displacement amplitudes, bump configurations, pivot locations, surface coatings, and lubricant were also evaluated. An understanding of the dynamic characteristics of bump foil strips resulting from this work offers designers a means for enhancing the design of high-performance compliant foil bearings.

The velocity field created by a shallow bump in a boundary layer

NASA Technical Reports Server (NTRS)

Gaster, Michael; Grosch, Chester E.; Jackson, Thomas L.

1994-01-01

We report the results of measurements of the disturbance velocity field generated in a boundary layer by a shallow three-dimensional bump oscillating at a very low frequency on the surface of a flat plate. Profiles of the mean velocity, the disturbance velocity at the fundamental frequency and at the first harmonic are presented. These profiles were measured both upstream and downstream of the oscillating bump. Measurements of the disturbance velocity were also made at various spanwise and downstream locations at a fixed distance from the boundary of one displacement thickness. Finally, the spanwise spectrum of the disturbances at three locations downstream of the bump are presented.

The 1600 Å Emission Bump in Protoplanetary Disks: A Spectral Signature of H2O Dissociation

NASA Astrophysics Data System (ADS)

France, Kevin; Roueff, Evelyne; Abgrall, Hervé

2017-08-01

The FUV continuum spectrum of many accreting pre-main sequence stars, Classical T Tauri Stars (CTTSs), does not continue smoothly from the well-studied Balmer continuum emission in the NUV, suggesting that additional processes contribute to the short-wavelength emission in these objects. The most notable spectral feature in the FUV continuum of some CTTSs is a broad emission approximately centered at 1600 Å, which has been referred to as the “1600 Å Bump.” The origin of this feature remains unclear. In an effort to better understand the molecular properties of planet-forming disks and the UV spectral properties of accreting protostars, we have assembled archival FUV spectra of 37 disk-hosting systems observed by the Hubble Space Telescope-Cosmic Origins Spectrograph. Clear 1600 Å Bump emission is observed above the smooth, underlying 1100-1800 Å continuum spectrum in 19/37 Classical T Tauri disks in the HST-COS sample, with the detection rate in transition disks (8/8) being much higher than that in primordial or non-transition sources (11/29). We describe a spectral deconvolution analysis to separate the Bump (spanning 1490-1690 Å) from the underlying FUV continuum, finding an average Bump luminosity L(Bump) ≈ 7 × 1029 erg s-1. Parameterizing the Bump with a combination of Gaussian and polynomial components, we find that the 1600 Å Bump is characterized by a peak wavelength λ o = 1598.6 ± 3.3 Å, with FWHM = 35.8 ± 19.1 Å. Contrary to previous studies, we find that this feature is inconsistent with models of H2 excited by electron -impact. We show that this Bump makes up between 5%-50% of the total FUV continuum emission in the 1490-1690 Å band and emits roughly 10%-80% of the total fluorescent H2 luminosity for stars with well-defined Bump features. Energetically, this suggests that the carrier of the 1600 Å Bump emission is powered by Lyα photons. We argue that the most likely mechanism is Lyα-driven dissociation of H2O in the inner disk, r ≲ 2 au. We demonstrate that non-thermally populated H2O fragments can qualitatively account for the observed emission (discrete and continuum) and find that the average Lyα-driven H2O dissociation rate is 1.7 × 1042 water molecules s-1. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc. under NASA contract NAS 5-26555.

Thermal conductivity on stud bump interconnection of high power COB LED

NASA Astrophysics Data System (ADS)

Sarukunaselan, K.; Ong, N. R.; Sauli, Z.; Mahmed, N.; Kirtsaeng, S.; Sakuntasathien, S.; Suppiah, S.; Alcain, J. B.; Retnasamy, V.

2017-09-01

In this paper, the impacts of bump dimensions and material conductivity on the thermal performances of a high power chip on board (COB) LED package were investigated using open source software, Elmer. The stud bump acted as interconnection join which has an extra role in dissipating heat generated by the chip to the ambience. Simulation data showed that for a bump with a fixed contact length of 1mm, the most suitable height was 171 µm with material conductivity of 238W/mK or 319W/mK. Materials with thermal conductivity of lower than 20W/mK, had the poorest heat dissipation irrespective of the height.

Cross-Validation of Survival Bump Hunting by Recursive Peeling Methods.

PubMed

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J Sunil

2014-08-01

We introduce a survival/risk bump hunting framework to build a bump hunting model with a possibly censored time-to-event type of response and to validate model estimates. First, we describe the use of adequate survival peeling criteria to build a survival/risk bump hunting model based on recursive peeling methods. Our method called "Patient Recursive Survival Peeling" is a rule-induction method that makes use of specific peeling criteria such as hazard ratio or log-rank statistics. Second, to validate our model estimates and improve survival prediction accuracy, we describe a resampling-based validation technique specifically designed for the joint task of decision rule making by recursive peeling (i.e. decision-box) and survival estimation. This alternative technique, called "combined" cross-validation is done by combining test samples over the cross-validation loops, a design allowing for bump hunting by recursive peeling in a survival setting. We provide empirical results showing the importance of cross-validation and replication.

Cross-Validation of Survival Bump Hunting by Recursive Peeling Methods

PubMed Central

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

2015-01-01

We introduce a survival/risk bump hunting framework to build a bump hunting model with a possibly censored time-to-event type of response and to validate model estimates. First, we describe the use of adequate survival peeling criteria to build a survival/risk bump hunting model based on recursive peeling methods. Our method called “Patient Recursive Survival Peeling” is a rule-induction method that makes use of specific peeling criteria such as hazard ratio or log-rank statistics. Second, to validate our model estimates and improve survival prediction accuracy, we describe a resampling-based validation technique specifically designed for the joint task of decision rule making by recursive peeling (i.e. decision-box) and survival estimation. This alternative technique, called “combined” cross-validation is done by combining test samples over the cross-validation loops, a design allowing for bump hunting by recursive peeling in a survival setting. We provide empirical results showing the importance of cross-validation and replication. PMID:26997922

Coincidence avoidance principle in surface haptic interpretation

PubMed Central

Manuel, Steven G.; Klatzky, Roberta L.; Peshkin, Michael A.; Colgate, James Edward

2015-01-01

When multiple fingertips experience force sensations, how does the brain interpret the combined sensation? In particular, under what conditions are the sensations perceived as separate or, alternatively, as an integrated whole? In this work, we used a custom force-feedback device to display force signals to two fingertips (index finger and thumb) as they traveled along collinear paths. Each finger experienced a pattern of forces that, taken individually, produced illusory virtual bumps, and subjects reported whether they felt zero, one, or two bumps. We varied the spatial separation between these bump-like force-feedback regions, from being much greater than the finger span to nearly exactly the finger span. When the bump spacing was the same as the finger span, subjects tended to report only one bump. We found that the results are consistent with a quantitative model of perception in which the brain selects a structural interpretation of force signals that relies on minimizing coincidence stemming from accidental alignments between fingertips and inferred surface structures. PMID:25675477

Comedones

MedlinePlus

Skin bumps - acne-like; Acne-like skin bumps; Whiteheads; Blackheads ... of cutaneous appendages. In: Patterson JW, ed. Weedon's Skin Pathology . 4th ed. Philadelphia, PA: Elsevier Churchill Livingstone; ...

Dynamic traversal of high bumps and large gaps by a small legged robot

NASA Astrophysics Data System (ADS)

Gart, Sean; Winey, Nastasia; de La Tijera Obert, Rafael; Li, Chen

Small animals encounter and negotiate diverse obstacles comparable in size or larger than themselves. In recent experiments, we found that cockroaches can dynamically traverse bumps up to 4 times hip height and gaps up to 1 body length. To better understand the physics that governs these locomotor transitions, we studied a small six-legged robot negotiating high bumps and large gaps and compared it to animal observations. We found that the robot was able to traverse bumps as large as 1 hip height and gaps as wide as 0.5 body length. For the bump, the robot often climbed over to traverse when initial body yaw was small, but was often deflected laterally and failed to traverse when initial body yaw was large. A simple locomotion energy landscape model explained these observations. For the gap, traversal probability decreased with gap width, which was well explained by a simple Lagrangian model of a forward-moving rigid body falling over the gap edge. For both the bump and the gap, animal performance far exceeded that of the robot, likely due to their relatively higher running speeds and larger rotational oscillations prior to and during obstacle traversal. Differences between animal and robot obstacle negotiation behaviors revealed that animals used active strategies to overcome potential energy barriers.

Detection of micro solder balls using active thermography and probabilistic neural network

NASA Astrophysics Data System (ADS)

He, Zhenzhi; Wei, Li; Shao, Minghui; Lu, Xingning

2017-03-01

Micro solder ball/bump has been widely used in electronic packaging. It has been challenging to inspect these structures as the solder balls/bumps are often embedded between the component and substrates, especially in flip-chip packaging. In this paper, a detection method for micro solder ball/bump based on the active thermography and the probabilistic neural network is investigated. A VH680 infrared imager is used to capture the thermal image of the test vehicle, SFA10 packages. The temperature curves are processed using moving average technique to remove the peak noise. And the principal component analysis (PCA) is adopted to reconstruct the thermal images. The missed solder balls can be recognized explicitly in the second principal component image. Probabilistic neural network (PNN) is then established to identify the defective bump intelligently. The hot spots corresponding to the solder balls are segmented from the PCA reconstructed image, and statistic parameters are calculated. To characterize the thermal properties of solder bump quantitatively, three representative features are selected and used as the input vector in PNN clustering. The results show that the actual outputs and the expected outputs are consistent in identification of the missed solder balls, and all the bumps were recognized accurately, which demonstrates the viability of the PNN in effective defect inspection in high-density microelectronic packaging.

A new modal-based approach for modelling the bump foil structure in the simultaneous solution of foil-air bearing rotor dynamic problems

NASA Astrophysics Data System (ADS)

Bin Hassan, M. F.; Bonello, P.

2017-05-01

Recently-proposed techniques for the simultaneous solution of foil-air bearing (FAB) rotor dynamic problems have been limited to a simple bump foil model in which the individual bumps were modelled as independent spring-damper (ISD) subsystems. The present paper addresses this limitation by introducing a modal model of the bump foil structure into the simultaneous solution scheme. The dynamics of the corrugated bump foil structure are first studied using the finite element (FE) technique. This study is experimentally validated using a purpose-made corrugated foil structure. Based on the findings of this study, it is proposed that the dynamics of the full foil structure, including bump interaction and foil inertia, can be represented by a modal model comprising a limited number of modes. This full foil structure modal model (FFSMM) is then adapted into the rotordynamic FAB problem solution scheme, instead of the ISD model. Preliminary results using the FFSMM under static and unbalance excitation conditions are proven to be reliable by comparison against the corresponding ISD foil model results and by cross-correlating different methods for computing the deflection of the full foil structure. The rotor-bearing model is also validated against experimental and theoretical results in the literature.

Properties of Dust Obscured Galaxies in the Nep-Deep Field

NASA Astrophysics Data System (ADS)

Oi, Nagisa; Matsuhara, Hideo; Pearson, Chris; Buat, Veronique; Burgarella, Denis; Malkan, Matt; Miyaji, Takamitsu; AKARI-NEP Team

2017-03-01

We selected 47 DOGs at z∼1.5 using optical R (or r^{'}), AKARI 18 μm, and 24 μm color in the AKARI North Ecliptic Pole (NEP) Deep survey field. Using the colors among 3, 4, 7, and 9μm, we classified them into 3 groups; bump DOGs (23 sources), power-law DOGs (16 sources), and unknown DOGs (8 sources). We built spectral energy distributions (SEDs) with optical to far-infrared photometric data and investigated their properties using SED fitting method. We found that AGN activity such as a AGN contribution to the infrared luminosity and a Chandra detection rate for bump and power-law DOGs are significantly different, while stellar component properties like a stellar mass and a star-formation rate are similar to each other. A specific star-formation rate range of power-law DOGs is slightly higher than that of bump DOGs with wide overlap. Herschel/PACS detection rates are almost the same between bump and power-law DOGs. On the other hand SPIRE detection rates show large differences between bump and power-law DOGs. These results might be explained by differences in dust temperatures. Both groups of DOGs host hot and/or warm dust (∼ 50 Kelvin), and many bump DOGs contain cooler dust (≤ 30 Kelvin)

Fluxless flip-chip bonding using a lead-free solder bumping technique

NASA Astrophysics Data System (ADS)

Hansen, K.; Kousar, S.; Pitzl, D.; Arab, S.

2017-09-01

With the LHC exceeding the nominal instantaneous luminosity, the current barrel pixel detector (BPIX) of the CMS experiment at CERN will reach its performance limits and undergo significant radiation damage. In order to improve detector performance in high luminosity conditions, the entire BPIX is replaced with an upgraded version containing an additional detection layer. Half of the modules comprising this additional layer are produced at DESY using fluxless and lead-free bumping and bonding techniques. Sequential solder-jetting technique is utilized to wet 40-μm SAC305 solder spheres on the silicon-sensor pads with electroless Ni, Pd and immersion Au (ENEPIG) under-bump metallization (UBM). The bumped sensors are flip-chip assembled with readout chips (ROCs) and then reflowed using a flux-less bonding facility. The challenges for jetting low solder volume have been analyzed and will be presented in this paper. An average speed of 3.4 balls per second is obtained to jet about 67 thousand solder balls on a single chip. On average, 7 modules have been produced per week. The bump-bond quality is evaluated in terms of electrical and mechanical properties. The peak-bump resistance is about 17.5 mΩ. The cross-section study revealed different types of intermetallic compounds (IMC) as a result of interfacial reactions between UBM and solder material. The effect of crystalline phases on the mechanical properties of the joint is discussed. The mean shear strength per bump after the final module reflow is about 16 cN. The results and sources of yield loss of module production are reported. The achieved yield is 95%.

Life-span retrieval of public events: Reminiscence bump for high-impact events, recency for others.

PubMed

Tekcan, Ali I; Boduroglu, Aysecan; Mutlutürk, Aysu; Aktan Erciyes, Aslı

2017-10-01

Although substantial evidence exists showing a reliable reminiscence bump for personal events, data regarding retrieval distributions for public events have been equivocal. The primary aim of the present study was to address life-span retrieval distributions of different types of public events in comparison to personal events, and to test whether the existing accounts of the bump can explain the distribution of public events. We asked a large national sample to report the most important, happiest, and saddest personal events and the most important, happiest, saddest, most proud, most fearful, and most shameful public events. We found a robust bump corresponding to the third decade of life for the happiest and the most important positive but not for the saddest and most important negative personal events. For the most important public events, a bump emerged only for the two most frequently mentioned events. Distributions of public events cued with emotions were marked by recency. These results point to potential differences in retrieval of important personal and public events. While the life-script framework well accounts for the findings regarding important personal events, a chronologically retroactive search seem to guide retrieval of public events. Reminiscence bump observed for the two public events suggest that age-at-event affects recall of public events to the degree that the events are high-impact ones that dominate nation's collective memory. Results provide further evidence that the bump is not unitary and points to importance of event type and memory elicitation method with regard to competing explanations of the phenomenon.

CFD Analysis of Flexible Thermal Protection System Shear Configuration Testing in the LCAT Facility

NASA Technical Reports Server (NTRS)

Ferlemann, Paul G.

2014-01-01

This paper documents results of computational analysis performed after flexible thermal protection system shear configuration testing in the LCAT facility. The primary objectives were to predict the shear force on the sample and the sensitivity of all surface properties to the shape of the sample. Bumps of 0.05, 0.10,and 0.15 inches were created to approximate the shape of some fabric samples during testing. A large amount of information was extracted from the CFD solutions for comparison between runs and also current or future flight simulations.

TOWARD DETECTING THE 2175 A DUST FEATURE ASSOCIATED WITH STRONG HIGH-REDSHIFT Mg II ABSORPTION LINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang Peng; Zhou Hongyan; Wang Junxian

2011-05-10

We report detections of 39 2175 A dust extinction bump candidates associated with strong Mg II absorption lines at z{approx} 1-1.8 on quasar spectra in Sloan Digital Sky Survey (SDSS) DR3. These strong Mg II absorption line systems are detected among 2951 strong Mg II absorbers with a rest equivalent width W{sub r} {lambda}2796> 1.0 A at 1.0 < z < 1.86, which is part of a full sample of 7421 strong Mg II absorbers compiled by Prochter et al. The redshift range of the absorbers is chosen to allow the 2175 A extinction features to be completely covered withinmore » the SDSS spectrograph operation wavelength range. An upper limit of the background quasar emission redshift at z = 2.1 is set to prevent the Ly{alpha} forest lines from contaminating the sensitive spectral region for the 2175 A bump measurements. The FM90 parameterization is applied to model the optical/UV extinction curve in the rest frame of Mg II absorbers of the 2175 A bump candidates. The simulation technique developed by Jiang et al. is used to derive the statistical significance of the candidate 2175 A bumps. A total of 12 absorbers are detected with 2175 A bumps at a 5{sigma} level of statistical significance, 10 are detected at a 4{sigma} level, and 17 are detected at a 3{sigma} level. Most of the candidate bumps in this work are similar to the relatively weak 2175 A bumps observed in the Large Magellanic Cloud LMC2 supershell rather than the strong ones observed in the Milky Way. This sample has greatly increased the total number of 2175 A extinction bumps measured on SDSS quasar spectra. Follow-up observations may rule out some of the possible false detections and reveal the physical and chemical natures of 2175 A quasar absorbers.« less

Probing the physics of newly born magnetars through observation of superluminous supernovae

NASA Astrophysics Data System (ADS)

Cheng, Quan; Zhang, Shuang-Nan; Yu, Yun-Wei; Zheng, Xiao-Ping

2018-05-01

The central engines of some superluminous supernovae (SLSNe) are generally suggested to be newly born fast rotating magnetars, which spin down mainly through magnetic dipole radiation and gravitational wave emission. We calculate the magnetar-powered SLSNe light curves (LCs) with the tilt angle evolution of newly born magnetars involved. We show that, depending on the internal toroidal magnetic fields B¯t, the initial spin periods Pi, and the radii RDU of direct Urca (DU) cores of newly born magnetars, as well as the critical temperature Tc for 3P2 neutron superfluidity, bumps could appear in the SLSNe LCs after the maximum lights when the tilt angles grow to π /2 . The value of Tc determines the arising time and the relative amplitude of a bump. The quantity RDU can affect the arising time and the luminosity of a bump, as well as the peak luminosity of a LC. For newly born magnetars with dipole magnetic fields Bd=5 ×1014 G , B¯t=4.6 ×1016 G , and Pi=1 ms , there are no bumps in the LCs if Tc=2 ×109 K , or RDU=1.5 ×105 cm . Moreover, it is interesting that a stronger B¯t will lead to both a brighter peak and a brighter bump in a LC. While keeping other quantities unchanged, the bump in the LC disappears for the magnetar with smaller Pi. We suggest that, once the SLSNe LCs with such kinds of bumps are observed, by fitting these LCs with our model, not only Bd and Pi of newly born magnetars but also the crucial physical quantities B¯t, RDU, and Tc could be determined. Nonobservation of SLSNe LCs with such kinds of bumps hitherto may already put some (though very rough) constraints on B¯t, Pi, RDU, and Tc. Therefore, observation of SLSNe LCs may provide a new approach to probe the physics of newly born magnetars.

Toward Detecting the 2175 Å Dust Feature Associated with Strong High-redshift Mg II Absorption Lines

NASA Astrophysics Data System (ADS)

Jiang, Peng; Ge, Jian; Zhou, Hongyan; Wang, Junxian; Wang, Tinggui

2011-05-01

We report detections of 39 2175 Å dust extinction bump candidates associated with strong Mg II absorption lines at z~ 1-1.8 on quasar spectra in Sloan Digital Sky Survey (SDSS) DR3. These strong Mg II absorption line systems are detected among 2951 strong Mg II absorbers with a rest equivalent width Wr λ2796> 1.0 Å at 1.0 < z < 1.86, which is part of a full sample of 7421 strong Mg II absorbers compiled by Prochter et al. The redshift range of the absorbers is chosen to allow the 2175 Å extinction features to be completely covered within the SDSS spectrograph operation wavelength range. An upper limit of the background quasar emission redshift at z = 2.1 is set to prevent the Lyα forest lines from contaminating the sensitive spectral region for the 2175 Å bump measurements. The FM90 parameterization is applied to model the optical/UV extinction curve in the rest frame of Mg II absorbers of the 2175 Å bump candidates. The simulation technique developed by Jiang et al. is used to derive the statistical significance of the candidate 2175 Å bumps. A total of 12 absorbers are detected with 2175 Å bumps at a 5σ level of statistical significance, 10 are detected at a 4σ level, and 17 are detected at a 3σ level. Most of the candidate bumps in this work are similar to the relatively weak 2175 Å bumps observed in the Large Magellanic Cloud LMC2 supershell rather than the strong ones observed in the Milky Way. This sample has greatly increased the total number of 2175 Å extinction bumps measured on SDSS quasar spectra. Follow-up observations may rule out some of the possible false detections and reveal the physical and chemical natures of 2175 Å quasar absorbers.

Flip-chip assembly and reliability using gold/tin solder bumps

NASA Astrophysics Data System (ADS)

Oppermann, Hermann; Hutter, Matthias; Klein, Matthias; Reichl, Herbert

2004-09-01

Au/Sn solder bumps are commonly used for flip chip assembly of optoelectronic and RF devices. They allow a fluxless assembly which is required to avoid contamination at optical interfaces. Flip chip assembly experiments were carried out using as plated Au/Sn bumps without prior bump reflow. An RF and reliability test vehicles comprise a GaAs chip which was flip chip soldered on a silicon substrate. Temperature cycling tests with and without underfiller were performed and the results are presented. The different failure modes for underfilled and non-underfilled samples were discussed and compared. Additional reliability tests were performed with flip chip bonding by gold thermocompression for comparison. The test results and the failure modes are discussed in detail.

Phytochemical Screening and Acute Toxicity of Aqueous Extract of Leaves of Conocarpus erectus Linnaeus in Swiss Albino Mice.

PubMed

Nascimento, Dayane K D; Souza, Ivone A DE; Oliveira, Antônio F M DE; Barbosa, Mariana O; Santana, Marllon A N; Pereira, Daniel F; Lira, Eduardo C; Vieira, Jeymesson R C

2016-09-01

Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae) known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamaracá (PE). The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves were used. The evaluation of acute toxicity of aqueous extract of C. erectus followed the model of Acute Toxicity Class based on OECD 423 Guideline, 2001. The majority molecules were identified: flavonoids, tannins and saponins. The LD50 was estimated at 2,000 mg/kg bw. Therefore, the aqueous extract showed low acute toxicity classified in category 5.

THE PROPERTIES OF THE 2175 A EXTINCTION FEATURE DISCOVERED IN GRB AFTERGLOWS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zafar, Tayyaba; Watson, Darach; Eliasdottir, Ardis

The unequivocal, spectroscopic detection of the 2175 A bump in extinction curves outside the Local Group is rare. To date, the properties of the bump have been examined in only two gamma-ray burst (GRB) afterglows (GRB 070802 and GRB 080607). In this work, we analyze in detail the detections of the 2175 Angstrom-Sign extinction bump in the optical spectra of two further GRB afterglows: GRB 080605 and 080805. We gather all available optical/near-infrared photometric, spectroscopic, and X-ray data to construct multi-epoch spectral energy distributions (SEDs) for both GRB afterglows. We fit the SEDs with the Fitzpatrick and Massa model withmore » a single or broken power law. We also fit a sample of 38 GRB afterglows, known to prefer a Small Magellanic Cloud (SMC)-type extinction curve, with the same model. We find that the SEDs of GRB 080605 and GRB 080805 at two epochs are fit well with a single power law with a derived extinction of A{sub V} = 0.52{sup +0.13}{sub -0.16} and 0.50{sup +0.13}{sub -0.10}, and 2.1{sup +0.7}{sub -0.6} and 1.5 {+-} 0.2, respectively. While the slope of the extinction curve of GRB 080805 is not well constrained, the extinction curve of GRB 080605 has an unusual very steep far-UV rise together with the 2175 A bump. Such an extinction curve has previously been found in only a small handful of sightlines in the Milky Way. One possible explanation of such an extinction curve may be dust arising from two different regions with two separate grain populations, however we cannot distinguish the origin of the curve. We finally compare the four 2175 A bump sightlines to the larger GRB afterglow sample and to Local Group sightlines. We find that while the width and central positions of the bumps are consistent with what is observed in the Local Group, the relative strength of the detected bump (A{sub bump}) for GRB afterglows is weaker for a given A{sub V} than for almost any Local Group sightline. Such dilution of the bump strength may offer tentative support to a dual dust-population scenario.« less

Empirical relationships between gas abundances and UV selective extinction

NASA Technical Reports Server (NTRS)

Joseph, Charles L.

1990-01-01

Several studies of gas-phase abundances in lines of sight through the outer edges of dense clouds are summarized. These lines of sight have 0.4 less than E(B-V) less than 1.1 and have inferred spatial densities of a few hundred cm(-3). The primary thrust of these studies has been to compare gaseous abundances in interstellar clouds that have various types of peculiar selective extinction. To date, the most notable result has been an empirical relationship between the CN/Fe I abundance ratio and the depth of the 2200 A extinction bump. It is not clear at the present time, however, whether these two parameters are linearly correlated or the data are organized into two discrete ensembles. Based on 19 samples and assuming the clouds form discrete ensembles, lines of sight that have a CN/Fe I abundance ratio greater than 0.3 (dex) appear to have a shallow 2.57 plus or minus 0.55 bump compared to 3.60 plus or minus 0.36 for other dense clouds and compared to the 3.6 Seaton (1979) average. The difference in the strength of the extinction bump between these two ensembles is 1.03 plus or minus 0.23. Although a high-resolution IUE survey of dense clouds is far from complete, the few lines of sight with shallow extinction bumps all show preferential depletion of certain elements, while those lines of sight with normal 2200 A bumps do not. Ca II, Cr II, and Mn II appear to exhibit the strongest preferential depletion compared to S II, P II, and Mg II. Fe II and Si II depletions also appear to be enhanced somewhat in the shallow-bump lines of sight. It should be noted that Copernicus data suggest all elements, including the so-called nondepletors, deplete in diffuse clouds (Snow and Jenkins 1980, Joseph 1988). Those lines of sight through dense clouds that have normal 2200 A extinction bumps appear to be extensions of the depletions found in the diffuse interstellar medium. That is, the overall level of depletion is enhanced, but the element-to-element abundances are similar to those in diffuse clouds. In a separate study, the abundances of neutral atoms were studied in a dense cloud having a shallow 2200 A bump and in one with a normal strength bump.

Aeroelasticity of morphing wings using neural networks

NASA Astrophysics Data System (ADS)

Natarajan, Anand

In this dissertation, neural networks are designed to effectively model static non-linear aeroelastic problems in adaptive structures and linear dynamic aeroelastic systems with time varying stiffness. The use of adaptive materials in aircraft wings allows for the change of the contour or the configuration of a wing (morphing) in flight. The use of smart materials, to accomplish these deformations, can imply that the stiffness of the wing with a morphing contour changes as the contour changes. For a rapidly oscillating body in a fluid field, continuously adapting structural parameters may render the wing to behave as a time variant system. Even the internal spars/ribs of the aircraft wing which define the wing stiffness can be made adaptive, that is, their stiffness can be made to vary with time. The immediate effect on the structural dynamics of the wing, is that, the wing motion is governed by a differential equation with time varying coefficients. The study of this concept of a time varying torsional stiffness, made possible by the use of active materials and adaptive spars, in the dynamic aeroelastic behavior of an adaptable airfoil is performed here. Another type of aeroelastic problem of an adaptive structure that is investigated here, is the shape control of an adaptive bump situated on the leading edge of an airfoil. Such a bump is useful in achieving flow separation control for lateral directional maneuverability of the aircraft. Since actuators are being used to create this bump on the wing surface, the energy required to do so needs to be minimized. The adverse pressure drag as a result of this bump needs to be controlled so that the loss in lift over the wing is made minimal. The design of such a "spoiler bump" on the surface of the airfoil is an optimization problem of maximizing pressure drag due to flow separation while minimizing the loss in lift and energy required to deform the bump. One neural network is trained using the CFD code FLUENT to represent the aerodynamic loading over the bump. A second neural network is trained for calculating the actuator loads, bump displacement and lift, drag forces over the airfoil using the finite element solver, ANSYS and the previously trained neural network. This non-linear aeroelastic model of the deforming bump on an airfoil surface using neural networks can serve as a fore-runner for other non-linear aeroelastic problems.

Foil Gas Thrust Bearings for High-Speed Turbomachinery

NASA Technical Reports Server (NTRS)

Edmonds, Brian; DellaCorte, Christopher; Dykas, Brian

2010-01-01

A methodology has been developed for the design and construction of simple foil thrust bearings intended for parametric performance testing and low marginal costs, supporting continued development of oil-free turbomachinery. A bearing backing plate is first machined and surface-ground to produce flat and parallel faces. Partial-arc slots needed to retain the foil components are then machined into the plate by wire electrical discharge machining. Slot thicknesses achievable by a single wire pass are appropriate to accommodate the practical range of foil thicknesses, leaving a small clearance in this hinged joint to permit limited motion. The backing plate is constructed from a nickel-based superalloy (Inconel 718) to allow heat treatment of the entire assembled bearing, as well as to permit hightemperature operation. However, other dimensionally stable materials, such as precipitation-hardened stainless steel, can also be used for this component depending on application. The top and bump foil blanks are cut from stacks of annealed Inconel X-750 foil by the same EDM process. The bump foil has several azimuthal slits separating it into five individual bump strips. This configuration allows for variable bump spacing, which helps to accommodate the effects of the varying surface velocity, thermal crowning, centrifugal dishing, and misalignment. Rectangular tabs on the foil blanks fit into the backing plate slots. For this application, a rather traditional set of conventionally machined dies is selected, and bump foil blanks are pressed into the dies for forming. This arrangement produces a set of bump foil dies for foil thrust bearings that provide for relatively inexpensive fabrication of various bump configurations, and employing methods and features from the public domain.

Point process analysis of noise in early invertebrate vision

PubMed Central

Vinnicombe, Glenn

2017-01-01

Noise is a prevalent and sometimes even dominant aspect of many biological processes. While many natural systems have adapted to attenuate or even usefully integrate noise, the variability it introduces often still delimits the achievable precision across biological functions. This is particularly so for visual phototransduction, the process responsible for converting photons of light into usable electrical signals (quantum bumps). Here, randomness of both the photon inputs (regarded as extrinsic noise) and the conversion process (intrinsic noise) are seen as two distinct, independent and significant limitations on visual reliability. Past research has attempted to quantify the relative effects of these noise sources by using approximate methods that do not fully account for the discrete, point process and time ordered nature of the problem. As a result the conclusions drawn from these different approaches have led to inconsistent expositions of phototransduction noise performance. This paper provides a fresh and complete analysis of the relative impact of intrinsic and extrinsic noise in invertebrate phototransduction using minimum mean squared error reconstruction techniques based on Bayesian point process (Snyder) filters. An integrate-fire based algorithm is developed to reliably estimate photon times from quantum bumps and Snyder filters are then used to causally estimate random light intensities both at the front and back end of the phototransduction cascade. Comparison of these estimates reveals that the dominant noise source transitions from extrinsic to intrinsic as light intensity increases. By extending the filtering techniques to account for delays, it is further found that among the intrinsic noise components, which include bump latency (mean delay and jitter) and shape (amplitude and width) variance, it is the mean delay that is critical to noise performance. As the timeliness of visual information is important for real-time action, this delay could potentially limit the speed at which invertebrates can respond to stimuli. Consequently, if one wants to increase visual fidelity, reducing the photoconversion lag is much more important than improving the regularity of the electrical signal. PMID:29077703

Planetesimal formation by an axisymmetric radial bump of the column density of the gas in a protoplanetary disk

NASA Astrophysics Data System (ADS)

Onishi, Isamu K.; Sekiya, Minoru

2017-04-01

We investigate the effect of a radial pressure bump in a protoplanetary disk on planetesimal formation. We performed the two-dimensional numerical simulation of the dynamical interaction of solid particles and gas with an initially defined pressure bump under the assumption of axisymmetry. The aim of this work is to elucidate the effects of the stellar vertical gravity that were omitted in a previous study. Our results are very different from the previous study, which omitted the vertical gravity. Because dust particles settle toward the midplane because of the vertical gravity to form a thin dust layer, the regions outside of the dust layer are scarcely affected by the back-reaction of the dust. Hence, the gas column density keeps its initial profile with a bump, and dust particles migrate toward the bump. In addition, the turbulence due to the Kelvin-Helmholtz instability caused by the difference of the azimuthal velocities between the inside and outside of the dust layer is suppressed where the radial pressure gradient is reduced by the pressure bump. The dust settling proceeds further where the turbulence is weak, and a number of dust clumps are formed. The dust density in some clumps exceeds the Roche density. Planetesimals are considered to be formed from these clumps owing to the self-gravity.[Figure not available: see fulltext.

Ultraviolet photometry from the Orbiting Astronomical Observatory. XX - The ultraviolet extinction bump

NASA Technical Reports Server (NTRS)

Savage, B. D.

1975-01-01

Ultraviolet extinction bumps are investigated in the interstellar extinction curves between 1800 and 3600 A for 36 stars which have (B-V) excesses ranging from 0.03 to 0.55 and are mostly confined to the brighter OB associations distributed along the galactic plane. Each extinction curve is found to have a broad bump which peaks near 2175 A and whose position and profile appear to be constant among all the stars. It is shown that the bump is probably interstellar in origin and that the constancy of its position and shape places such severe restrictions on grain geometrical parameters that classical scattering theory cannot be used to explain the feature unless the dust grains in widely separated regions of space and with very different physical conditions are assumed to have nearly identical size and shape distributions. Three extinction curves which extend to 1100 A are examined and found to have the same general characteristics as the others. Several extinction curves are analyzed for fine structure, but no convincing evidence is found in the present interval. Some processes are discussed which may be responsible for the bumps.

Lichen Nitidus

MedlinePlus

... from pinpoint to pinhead size. Shape. They are flat topped and round. Color. Bumps are usually the ... usually characterized by patches of red or purple, flat-topped, itchy bumps on the skin or lacy ...

Testing of advanced technique for linear lattice and closed orbit correction by modeling its application for iota ring at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanov, A.

Many modern and most future accelerators rely on precise configuration of lattice and trajectory. The Integrable Optics Test Accelerator (IOTA) at Fermilab that is coming to final stages of construction will be used to test advanced approaches of control over particles dynamics. Various experiments planned at IOTA require high flexibility of lattice configuration as well as high precision of lattice and closed orbit control. Dense element placement does not allow to have ideal configuration of diagnostics and correctors for all planned experiments. To overcome this limitations advanced method of lattice an beneficial for other machines. Developed algorithm is based onmore » LOCO approach, extended with various sets of other experimental data, such as dispersion, BPM BPM phase advances, beam shape information from synchrotron light monitors, responses of closed orbit bumps to variations of focusing elements and other. Extensive modeling of corrections for a big number of random seed errors is used to illustrate benefits from developed approach.« less

Electrical characteristics for Sn-Ag-Cu solder bump with Ti/Ni/Cu under-bump metallization after temperature cycling tests

NASA Astrophysics Data System (ADS)

Shih, T. I.; Lin, Y. C.; Duh, J. G.; Hsu, Tom

2006-10-01

Lead-free solder bumps have been widely used in current flip-chip technology (FCT) due to environmental issues. Solder joints after temperature cycling tests were employed to investigate the interfacial reaction between the Ti/Ni/Cu under-bump metallization and Sn-Ag-Cu solders. The interfacial morphology and quantitative analysis of the intermetallic compounds (IMCs) were obtained by electron probe microanalysis (EPMA) and field emission electron probe microanalysis (FE-EPMA). Various types of IMCs such as (Cu1-x,Agx)6Sn5, (Cu1-y,Agy)3Sn, and (Ag1-z,Cuz)3Sn were observed. In addition to conventional I-V measurements by a special sample preparation technique, a scanning electron microscope (SEM) internal probing system was introduced to evaluate the electrical characteristics in the IMCs after various test conditions. The electrical data would be correlated to microstructural evolution due to the interfacial reaction between the solder and under-bump metallurgy (UBM). This study demonstrated the successful employment of an internal nanoprobing approach, which would help further understanding of the electrical behavior within an IMC layer in the solder/UBM assembly.

Photogrammetric 3d Acquisition and Analysis of Medicamentous Induced Pilomotor Reflex ("goose Bumps")

NASA Astrophysics Data System (ADS)

Schneider, D.; Hecht, A.

2016-06-01

In a current study at the University Hospital Dresden, Department of Neurology, the autonomous function of nerve fibres of the human skin is investigated. For this purpose, a specific medicament is applied on a small area of the skin of a test person which results in a local reaction (goose bumps). Based on the extent of the area, where the stimulation of the nerve fibres is visible, it can be concluded how the nerve function of the skin works. The aim of the investigation described in the paper is to generate 3D data of these goose bumps. Therefore, the paper analyses and compares different photogrammetric surface measurement techniques in regard to their suitability for the 3D acquisition of silicone imprints of the human skin. Furthermore, an appropriate processing procedure for analysing the recorded point cloud data is developed and presented. It was experimentally proven that by using (low-cost) photogrammetric techniques medicamentous induced goose bumps can be acquired in three dimensions and can be analysed almost fully automatically from the perspective of medical research questions. The relative accuracy was determined with 1% (RMSE) of the area resp. the volume of an individual goose bump.

Sedimentary features of the Blackhawk formation (Cretaceous) at Sunnyside, Carbon County, Utah

USGS Publications Warehouse

Maberry, John O.

1968-01-01

The Blackhawk Formation at Sunnyside, Utah, was deposited along the western margin of the Western Interior Cretaceous sea during southeastward withdrawal of the sea. Sand was the dominant type of land-derived sediment deposited in the Sunnyside district during the regressive phases. Sand bodies prograded seaward in response to changing sediment supply from a source west of Sunnyside. Where conditions were favorable for the accumulation of vegetable material, peat deposits formed and were later changed to bituminous Coal by diagenesis. Studies of the coal bed show that the coals were formed from accumulation of small, low-growing plants and plant debris that was transported into the area of accumulation. Remains of large plants in the coals are rare. Trace fossils, which are tracks, trails and burrows formed by organisms and preserved in the rock, are extremely abundant in the Blackhawk rocks. These biogenic sedimentary structures are common in Cretaceous deposits throughout the western United States. Trace fossil distribution in the rocks is controlled by the depositional environment preferred by their creators. A study of the trace fossils of a. locality allows a more precise determination of the conditions during deposition of the sediments. Water depth, bottom conditions, salinity, current velocity and amount of suspended nutrients in the water are some of the environmental factors that may be reconstructed by studying trace fossils. The Blackhawk Formation at Sunnyside comprises the members, the Kenilworth Member and the Sunnyside Member. Field studies show that the formation may be further subdivided in the Sunnyside district., according to the precepts of units of mappable thickness and similar lithologic characteristics. The Blackhawk pinches out eastward and north. ward into the Mancos Shale, and names for submembers become meaningless. Names are of value in the region of interest, however, because of the prominence of the named units. Coal mining is the main industry of the Book Cliffs region. Mines of the Sunnyside district are plagued by coal mine bumps, which are sudden, catastrophic releases of stress in the coal. Bumps cause loss of life, property age, and loss of profit to mining companies. Bumps occur when shear stress built up in the coal exceeds the shear Strength of the coal. Differential overburden pressure, faulting and tectonic activity, and lithology and structure of roof rocks are factors which influence bumps. Petroleum and natural gas (methane), which occur locally in pockets in the roof rocks above coal beds, may be diagenetic products of organic-rich sediments.

Trapping saturation of the bump-on-tail instability and electrostatic harmonic excitation in earth's foreshock

NASA Technical Reports Server (NTRS)

Klimas, Alexander J.

1990-01-01

The Vlasov simulation is used to examine the trapping saturation of the bump-on-tail instability both with and without mode-mode coupling and subsequent harmonic excitation. It is found that adding the pumped harmonic modes leads to a significant difference in the behavior of the phase-space distribution function near the unstable bump at the saturation time of the instability. The pumped modes permit rapid plateau formation on the space-averaged velocity distribution, in effect preventing the onset of the quasi-linear velocity-diffusion saturation mechanism.

Effect of suspension systems on the physiological and psychological responses to sub-maximal biking on simulated smoothand bumpy tracks.

PubMed

Titlestad, John; Fairlie-Clarke, Tony; Whittaker, Arthur; Davie, Mark; Watt, Ian; Grant, Stanley

2006-02-01

The aim of this study was to compare the physiological and psychological responses of cyclists riding on a hard tail bicycle and on a full suspension bicycle. Twenty males participated in two series of tests. A test rig held the front axle of the bicycle steady while the rear wheel rotated against a heavy roller with bumps (or no bumps) on its surface. In the first series of tests, eight participants (age 19-27 years, body mass 65-82 kg) were tested on both the full suspension and hard tail bicycles with and without bumps fitted to the roller. The second series of test repeated the bump tests with a further six participants (age 22-31 years, body mass 74-94 kg) and also involved an investigation of familiarization effects with the final six participants (age 21-30 years, body mass 64-80 kg). Heart rate, oxygen consumption (VO(2)), rating of perceived exertion (RPE) and comfort were recorded during 10 min sub-maximal tests. Combined data for the bumps tests show that the full suspension bicycle was significantly different (P < 0.001) from the hard tail bicycle on all four measures. Oxygen consumption, heart rate and RPE were lower on average by 8.7 (s = 3.6) ml . kg(-1) . min(-1), 32.1 (s = 12.1) beats . min(-1) and 2.6 (s = 2.0) units, respectively. Comfort scores were higher (better) on average by 1.9 (s = 0.8) units. For the no bumps tests, the only statistically significant difference (P = 0.008) was in VO(2), which was lower for the hard tail bicycle by 2.2 (s = 1.7) ml . kg(-1) . min(-1). The results indicate that the full suspension bicycle provides a physiological and psychological advantage over the hard tail bicycle during simulated sub-maximal exercise on bumps.

The effects of wedge roughness on Mach formation

NASA Astrophysics Data System (ADS)

Needham, C. E.; Happ, H. J.; Dawson, D. F.

A modified HULL hydrodynamic model was used to simulate shock reflection on wedges fitted with bumps representing varying degrees of roughness. The protuberances ranged from 0.02-0.2 cm in size. The study was directed at the feasibility of and techniques for defining parametric fits for surface roughness in the HULL code. Of interest was the self-similarity of the flows, so increasingly larger protuberances would simply enhance the resolution of the calculations. The code was designed for compressible, inviscid, nonconducting fluid flows. An equation of state provides closure and a finite difference algorithm is applied to solve governing equations for conservation of mass, momentum and energy. Self-similarity failed as the surface bumps grew larger and protruded further into the flowfield. It is noted that bumps spaced further apart produced greater interference for the passage of the Mach stem than did bumps placed closer together.

Effect of current crowding on whisker growth at the anode in flip chip solder joints

NASA Astrophysics Data System (ADS)

Ouyang, Fan-Yi; Chen, Kai; Tu, K. N.; Lai, Yi-Shao

2007-12-01

Owing to the line-to-bump configuration in flip chip solder joints, current crowding occurs when electrons enter into or exit from the solder bump. At the cathode contact, where electrons enter into the bump, current crowding induced pancake-type void formation has now been observed widely. At the anode contact, where electrons exit from the bump, we report here that whisker is formed. Results of both eutectic SnPb and SnAgCu solder joints are presented and compared. The cross-sectioned surface in SnPb showed dimple and bulge after electromigration, while that of SnAgCu remained flat. The difference is due to a larger back stress in the SnAgCu, consequently, electromigration in SnAgCu is slower than that in SnPb. Nanoindentation markers were used to measure the combined atomic fluxes of back stress and electromigration.

Studies of beam injection with a compensated bump and uncompensated bump in a synchrotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akbar Fakhri, Ali; Prajapati, S. K.; Ghodke, A. D.

2013-08-15

Synchrotron radiation sources Indus-1 and Indus-2 have a synchrotron as the common injector. A three kicker compensated bump injection scheme was employed for beam injection into this synchrotron. The stored beam current in the synchrotron is higher, when all the three kickers are operated at the same current than when kickers are operated at currents required to generate compensated bump. Beam dynamics studies have been done to understand why this happens. Theoretical studies indicate that higher stored current in the later case is attributed to smaller residual oscillations of injected beam. These studies also reveal that if the angle ofmore » the injected beam during beam injection is kept varying, the performance could be further improved. This is experimentally confirmed by injecting the beam on rising part of the injection septum magnet current pulse.« less

Recommendations for design, construction, and maintenance of bridge approach slabs.

DOT National Transportation Integrated Search

2012-09-01

Settlement and heave related movements of bridge approach slabs relative to bridge decks create a bump in : the roadway. Several problems arise from these bumps, which include poor riding conditions, potential : vehicle damage, loss of vehicle contro...

By the People, for the People: the Crowdsourcing of "STREETBUMP": AN Automatic Pothole Mapping App

NASA Astrophysics Data System (ADS)

Carrera, F.; Guerin, S.; Thorp, J. B.

2013-05-01

This paper traces the genesis and development of StreetBump, a smartphone application to map the location of potholes in Boston, Massachusetts. StreetBump belongs to a special category of "subliminal" crowdsourcing mobile applications that turn humans into sensors. Once started, it automatically collects road condition information without any human intervention, using the accelerometers and GPS inside smartphones. The StreetBump app evolved from a hardware device designed and built by WPI's City Lab starting in 2003, which was originally intended to measure and map boat wakes in the city of Venice, Italy (Chiu, 2004). A second version of the custom hardware with onboard GPS and accelerometers was adapted to use in Boston, Massachusetts, to map road damage (potholes) in 2006 (Angelini, 2006). In 2009, Prof. Carrera proposed to the newly created office of New Urban Mechanics in the City of Boston to migrate the concept to Smartphones, based on the Android platform. The first prototype of the mobile app, called StreetBump, was released in 2010 by the authors (Harmon, 2010). In 2011, the app provided the basis for a worldwide Innocentive competition to develop the best postprocessing algorithms to identify the real potholes vs. other phone bumps (Moskowitz, 2011). Starting in 2012, the City of Boston has begun using a subsequent version of the app to operationally manage road repairs based on the data collected by StreetBump. The novelty of this app is not purely technological, but lies also in the top-to-bottom crowdsourcing of all its components. The app was designed to rely on the crowd to confirm the presence of damage though repeat hits (or lack thereof) as more users travel the same roads over time. Moreover, the non-trivial post-processing of the StreetBump data was itself the subject of a crowdsourced competition through an Innocentive challenge for the best algorithm. The release of the StreetBump code as open-source allowed the development of the final version of the app now used on a daily basis by the Department of Public Works in Boston, thus making it perhaps the first example of an app that was crowdsourced "from soup to nuts".

Investigation of electromigration behavior in lead-free flip chip solder bumps

NASA Astrophysics Data System (ADS)

Kalkundri, Kaustubh Jayant

Packaging technology has also evolved over time in an effort to keep pace with the demanding requirements. Wirebond and flip chip packaging technologies have become extremely versatile and ubiquitous in catering to myriad applications due to their inherent potential. This research is restricted strictly to flip chip technology. This technology incorporates a process in which the bare chip is turned upside down, i.e., active face down, and is bonded through the I/O to the substrate, hence called flip chip. A solder interconnect that provides electrical connection between the chip and substrate is bumped on a processed silicon wafer prior to dicing for die-attach. The assembly is then reflow-soldered followed by the underfill process to provide the required encapsulation. The demand for smaller and lighter products has increased the number of I/Os without increasing the package sizes, thereby drastically reducing the size of the flip chip solder bumps and their pitch. Reliability assessment and verification of these devices has gained tremendous importance due to their shrinking size. To add to the complexity, changing material sets that are results of recently enacted lead-free solder legislations have raised some compatibility issues that are already being researched. In addition to materials and process related flip chip challenges such as solder-flux compatibility, Coefficient of Thermal Expansion (CTE) mismatch, underfill-flux compatibility and thermal management, flip chip packages are vulnerable to a comparatively newer challenge, namely electromigration observed in solder bumps. It is interesting to note that electromigration has come to the forefront of challenges only recently. It has been exacerbated by the reduction in bump cross-section due to the seemingly continuous shrinking in package size over time. The focus of this research was to understand the overall electromigration behavior in lead-free (SnAg) flip chip solder bumps. The objectives of the research were to comprehend the physics of failure mechanism in electromigration for lead-free solder bumps assembled in a flip chip ceramic package having thick copper under bump metallization and to estimate the unknown critical material parameters from Black's equation that describe failure due to electromigration. In addition, the intent was to verify the 'use condition reliability' by extrapolation from experimental conditions. The methodology adopted for this research was comprised of accelerated electromigration tests on SnAg flip chip solder bumps assembled on ceramic substrate with a thick copper under bump metallization. The experimental approach was comprised of elaborate measurement of the temperature of each sample by separate metallization resistance exhibiting positive resistance characteristics to overcome the variation in Joule heating. After conducting the constant current experiments and analyzing the failed samples, it was found that the primary electromigration failure mode observed was the dissolution of the thick copper under bump metallization in the solder, leading to a change in resistance. The lifetime data obtained from different experiments was solved simultaneously using a multiple regression approach to yield the unknown Black's equation parameters of current density exponent and activation energy. In addition to the implementation of a systematic failure analysis and data analysis procedure, it was also deduced that thermomigration due to the temperature gradient across the chip does impact the overall electromigration behavior. This research and the obtained results were significant in bridging the gap for an overall understanding of this critical failure mode observed in flip chip solder bumps. The measurement of each individual sample temperature instead of an average temperature enabled an accurate analysis for predicting the 'use condition reliability' of a comparable product. The obtained results and the conclusions can be used as potential inputs in future designs and newer generations of flip chip devices that might undergo aggressive scaling. This will enable these devices to retain their functionality during their intended useful life with minimal threat of failure due to the potent issue of electromigration. (Abstract shortened by UMI.)

Recommendations for design, construction, and maintenance of bridge approach slabs : synthesis report.

DOT National Transportation Integrated Search

2009-04-01

Bridge approaches provide smooth and safe transition of vehicles from highway pavements to bridge : structures. However, settlement of the bridge approach slab relative to bridge decks usually creates a : bump in the roadway. The bump causes inconven...

On reducing bumps at pavement-bridge interface.

DOT National Transportation Integrated Search

2010-12-21

This report contains the causes and long-term solutions to the bumps at bridge/approach slab and/or approach slab/pavement interface. A research was conducted on both structural and geotechnical aspects of an approach slab. : A 3-D finite element ana...

Experiments and theory on parametric instabilities excited in HF heating experiments at HAARP

NASA Astrophysics Data System (ADS)

Kuo, Spencer; Snyder, Arnold; Lee, M. C.

2014-06-01

Parametric instabilities excited by O-mode HF heater and the induced ionospheric modification were explored via HAARP digisonde operated in a fast mode. The impact of excited Langmuir waves and upper hybrid waves on the ionosphere are manifested by bumps in the virtual spread, which expand the ionogram echoes upward as much as 140 km and the downward range spread of the sounding echoes, which exceeds 50 km over a significant frequency range. The theory of parametric instabilities is presented. The theory identifies the ionogram bump located between the 3.2 MHz heater frequency and the upper hybrid resonance frequency and the bump below the upper hybrid resonance frequency to be associated with the Langmuir and upper hybrid instabilities, respectively. The Langmuir bump is located close to the upper hybrid resonance frequency, rather than to the heater frequency, consistent with the theory. Each bump in the virtual height spread of the ionogram is similar to the cusp occurring in daytime ionograms at the E-F2 layer transition, indicating that there is a small ledge in the density profile similar to E-F2 layer transitions. The experimental results also show that the strong impact of the upper hybrid instability on the ionosphere can suppress the Langmuir instability.

Experiments and theory on parametric instabilities excited in HF heating experiments at HAARP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuo, Spencer; Snyder, Arnold; Lee, M. C.

2014-06-15

Parametric instabilities excited by O-mode HF heater and the induced ionospheric modification were explored via HAARP digisonde operated in a fast mode. The impact of excited Langmuir waves and upper hybrid waves on the ionosphere are manifested by bumps in the virtual spread, which expand the ionogram echoes upward as much as 140 km and the downward range spread of the sounding echoes, which exceeds 50 km over a significant frequency range. The theory of parametric instabilities is presented. The theory identifies the ionogram bump located between the 3.2 MHz heater frequency and the upper hybrid resonance frequency and the bump below themore » upper hybrid resonance frequency to be associated with the Langmuir and upper hybrid instabilities, respectively. The Langmuir bump is located close to the upper hybrid resonance frequency, rather than to the heater frequency, consistent with the theory. Each bump in the virtual height spread of the ionogram is similar to the cusp occurring in daytime ionograms at the E-F2 layer transition, indicating that there is a small ledge in the density profile similar to E-F2 layer transitions. The experimental results also show that the strong impact of the upper hybrid instability on the ionosphere can suppress the Langmuir instability.« less

The Red-giant Branch Bump Revisited: Constraints on Envelope Overshooting in a Wide Range of Masses and Metallicities

NASA Astrophysics Data System (ADS)

Khan, Saniya; Hall, Oliver J.; Miglio, Andrea; Davies, Guy R.; Mosser, Benoît; Girardi, Léo; Montalbán, Josefina

2018-06-01

The red-giant branch bump provides valuable information for the investigation of the internal structure of low-mass stars. Because current models are unable to accurately predict the occurrence and efficiency of mixing processes beyond convective boundaries, one can use the luminosity of the bump—a diagnostic of the maximum extension of the convective envelope during the first-dredge up—as a calibrator for such processes. By combining asteroseismic and spectroscopic constraints, we expand the analysis of the bump to masses and metallicities beyond those previously accessible using globular clusters. Our data set comprises nearly 3000 red-giant stars observed by Kepler and with APOGEE spectra. Using statistical mixture models, we are able to detect the bump in the average seismic parameters ν max and < {{Δ }}ν > , and show that its observed position reveals general trends with mass and metallicity in line with expectations from models. Moreover, our analysis indicates that standard stellar models underestimate the depth of efficiently mixed envelopes. The inclusion of significant overshooting from the base of the convective envelope, with an efficiency that increases with decreasing metallicity, allows us to reproduce the observed location of the bump. Interestingly, this trend was also reported in previous studies of globular clusters.

Applying robust design to study the effects of stratigraphic characteristics on brittle failure and bump potential in a coal mine

PubMed Central

Kim, Bo-Hyun; Larson, Mark K.; Lawson, Heather E.

2018-01-01

Bumps and other types of dynamic failure have been a persistent, worldwide problem in the underground coal mining industry, spanning decades. For example, in just five states in the U.S. from 1983 to 2014, there were 388 reportable bumps. Despite significant advances in mine design tools and mining practices, these events continue to occur. Many conditions have been associated with bump potential, such as the presence of stiff units in the local geology. The effect of a stiff sandstone unit on the potential for coal bumps depends on the location of the stiff unit in the stratigraphic column, the relative stiffness and strength of other structural members, and stress concentrations caused by mining. This study describes the results of a robust design to consider the impact of different lithologic risk factors impacting dynamic failure risk. Because the inherent variability of stratigraphic characteristics in sedimentary formations, such as thickness, engineering material properties, and location, is significant and the number of influential parameters in determining a parametric study is large, it is impractical to consider every simulation case by varying each parameter individually. Therefore, to save time and honor the statistical distributions of the parameters, it is necessary to develop a robust design to collect sufficient sample data and develop a statistical analysis method to draw accurate conclusions from the collected data. In this study, orthogonal arrays, which were developed using the robust design, are used to define the combination of the (a) thickness of a stiff sandstone inserted on the top and bottom of a coal seam in a massive shale mine roof and floor, (b) location of the stiff sandstone inserted on the top and bottom of the coal seam, and (c) material properties of the stiff sandstone and contacts as interfaces using the 3-dimensional numerical model, FLAC3D. After completion of the numerical experiments, statistical and multivariate analysis are performed using the calculated results from the orthogonal arrays to analyze the effect of these variables. As a consequence, the impact of each of the parameters on the potential for bumps is quantitatively classified in terms of a normalized intensity of plastic dissipated energy. By multiple regression, the intensity of plastic dissipated energy and migration of the risk from the roof to the floor via the pillars is predicted based on the value of the variables. The results demonstrate and suggest a possible capability to predict the bump potential in a given rock mass adjacent to the underground excavations and pillars. Assessing the risk of bumps is important to preventing fatalities and injuries resulting from bumps. PMID:29416902

Lessons learned from starting Rochester Precision Optics

NASA Astrophysics Data System (ADS)

Hurley, William P.

2014-12-01

Thank you very much for coming to attend this talk. I see a few familiar faces in the crowd that have had their own journeys, and if you're thinking of starting your own optics business, this is not the authoritative talk on how to do. It's just a talk on what I've learned from my journey and some of my own stories on Lessons Learned. It does tie into some of the previous talks, and I do give credit to some mentors. The developments I've been involved with do make use of the ability to adapt and change, and there have been Bumps in the Road here and there, and I'll tell you a little bit more about that during this Talk.

Weak bump quasars

NASA Technical Reports Server (NTRS)

Wilkes, B. J.; Mcdowell, J.

1994-01-01

Research into the optical, ultraviolet and infrared continuum emission from quasars and their host galaxies was carried out. The main results were the discovery of quasars with unusually weak infrared emission and the construction of a quantitative estimate of the dispersion in quasar continuum properties. One of the major uncertainties in the measurement of quasar continuum strength is the contribution to the continuum of the quasar host galaxy as a function of wavelength. Continuum templates were constructed for different types of host galaxy and individual estimates made of the decomposed quasar and host continua based on existing observations of the target quasars. The results are that host galaxy contamination is worse than previously suspected, and some apparent weak bump quasars are really normal quasars with strong host galaxies. However, the existence of true weak bump quasars such as PHL 909 was confirmed. The study of the link between the bump strength and other wavebands was continued by comparing with IRAS data. There is evidence that excess far infrared radiation is correlated with weaker ultraviolet bumps. This argues against an orientation effect and implies a probable link with the host galaxy environment, for instance the presence of a luminous starburst. However, the evidence still favors the idea that reddening is not important in those objects with ultraviolet weak bumps. The same work has led to the discovery of a class of infrared weak quasars. Pushing another part of the envelope of quasar continuum parameter space, the IR-weak quasars have implications for understanding the effects of reddening internal to the quasars, the reality of ultraviolet turnovers, and may allow further tests of the Phinney dust model for the IR continuum. They will also be important objects for studying the claimed IR to x-ray continuum correlation.

The BUMP model of response planning: intermittent predictive control accounts for 10 Hz physiological tremor.

PubMed

Bye, Robin T; Neilson, Peter D

2010-10-01

Physiological tremor during movement is characterized by ∼10 Hz oscillation observed both in the electromyogram activity and in the velocity profile. We propose that this particular rhythm occurs as the direct consequence of a movement response planning system that acts as an intermittent predictive controller operating at discrete intervals of ∼100 ms. The BUMP model of response planning describes such a system. It forms the kernel of Adaptive Model Theory which defines, in computational terms, a basic unit of motor production or BUMP. Each BUMP consists of three processes: (1) analyzing sensory information, (2) planning a desired optimal response, and (3) execution of that response. These processes operate in parallel across successive sequential BUMPs. The response planning process requires a discrete-time interval in which to generate a minimum acceleration trajectory to connect the actual response with the predicted future state of the target and compensate for executional error. We have shown previously that a response planning time of 100 ms accounts for the intermittency observed experimentally in visual tracking studies and for the psychological refractory period observed in double stimulation reaction time studies. We have also shown that simulations of aimed movement, using this same planning interval, reproduce experimentally observed speed-accuracy tradeoffs and movement velocity profiles. Here we show, by means of a simulation study of constant velocity tracking movements, that employing a 100 ms planning interval closely reproduces the measurement discontinuities and power spectra of electromyograms, joint-angles, and angular velocities of physiological tremor reported experimentally. We conclude that intermittent predictive control through sequential operation of BUMPs is a fundamental mechanism of 10 Hz physiological tremor in movement. Copyright © 2010 Elsevier B.V. All rights reserved.

Functional Cooperation between the IP3 Receptor and Phospholipase C Secures the High Sensitivity to Light of Drosophila Photoreceptors In Vivo

PubMed Central

Kohn, Elkana; Katz, Ben; Yasin, Bushra; Peters, Maximilian; Rhodes, Elisheva; Zaguri, Rachel; Weiss, Shirley

2015-01-01

Drosophila phototransduction is a model system for the ubiquitous phosphoinositide signaling. In complete darkness, spontaneous unitary current events (dark bumps) are produced by spontaneous single Gqα activation, while single-photon responses (quantum bumps) arise from synchronous activation of several Gqα molecules. We have recently shown that most of the spontaneous single Gqα activations do not produce dark bumps, because of a critical phospholipase Cβ (PLCβ) activity level required for bump generation. Surpassing the threshold of channel activation depends on both PLCβ activity and cellular [Ca2+], which participates in light excitation via a still unclear mechanism. We show here that in IP3 receptor (IP3R)-deficient photoreceptors, both light-activated Ca2+ release from internal stores and light sensitivity were strongly attenuated. This was further verified by Ca2+ store depletion, linking Ca2+ release to light excitation. In IP3R-deficient photoreceptors, dark bumps were virtually absent and the quantum-bump rate was reduced, indicating that Ca2+ release from internal stores is necessary to reach the critical level of PLCβ catalytic activity and the cellular [Ca2+] required for excitation. Combination of IP3R knockdown with reduced PLCβ catalytic activity resulted in highly suppressed light responses that were partially rescued by cellular Ca2+ elevation, showing a functional cooperation between IP3R and PLCβ via released Ca2+. These findings suggest that in contrast to the current dogma that Ca2+ release via IP3R does not participate in light excitation, we show that released Ca2+ plays a critical role in light excitation. The positive feedback between PLCβ and IP3R found here may represent a common feature of the inositol-lipid signaling. PMID:25673847

Fundamental study of microelectronic chip response under laser ultrasonic-interferometric inspection using C-scan method

NASA Astrophysics Data System (ADS)

Yang, Lei; Gong, Jie; Ume, I. Charles

2014-02-01

In modern surface mount packaging technologies, such as flip chips, chip scale packages, and ball grid arrays(BGA), chips are attached to the substrates/printed wiring board (PWB) using solder bump interconnections. The quality of solder bumps between the chips and the substrate/board is difficult to inspect. Laser ultrasonic-interferometric technique was proved to be a promising approach for solder bump inspection because of its noncontact and nondestructive characteristics. Different indicators extracted from received signals have been used to predict the potential defects, such as correlation coefficient, error ratio, frequency shifting, etc. However, the fundamental understanding of the chip behavior under laser ultrasonic inspection is still missing. Specifically, it is not sure whether the laser interferometer detected out-of-plane displacements were due to wave propagation or structural vibration when the chip was excited by pulsed laser. Plus, it is found that the received signals are chip dependent. Both challenges impede the interpretation of acquired signals. In this paper, a C-scan method was proposed to study the underlying phenomenon during laser ultrasonic inspection. The full chip was inspected. The response of the chip under laser excitation was visualized in a movie resulted from acquired signals. Specifically, a BGA chip was investigated to demonstrate the effectiveness of this method. By characterizing signals using discrete wavelet transform(DWT), both ultrasonic wave propagation and vibration were observed. Separation of them was successfully achieved using ideal band-pass filter and visualized in resultant movies, too. The observed ultrasonic waves were characterized and their respective speeds were measured by applying 2-D FFT. The C-scan method, combined with different digital signal processing techniques, was proved to be an very effective methodology to learn the behavior of chips under laser excitation. This general procedure can be applied to any unknown chip before inspection. A wealth of information can be provided by this learning procedure, which greatly benefits the interpretation of inspection signals afterwards.

GIANT X-RAY BUMP IN GRB 121027A: EVIDENCE FOR FALL-BACK DISK ACCRETION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu Xuefeng; Hou Shujin; Lei Weihua, E-mail: xfwu@pmo.ac.cn, E-mail: leiwh@hust.edu.cn

2013-04-20

A particularly interesting discovery in observations of GRB 121027A is that of a giant X-ray bump detected by the Swift/X-Ray Telescope. The X-ray afterglow re-brightens sharply at {approx}10{sup 3} s after the trigger by more than two orders of magnitude in less than 200 s. This X-ray bump lasts for more than 10{sup 4} s. It is quite different from typical X-ray flares. In this Letter we propose a fall-back accretion model to interpret this X-ray bump within the context of the collapse of a massive star for a long-duration gamma-ray burst. The required fall-back radius of {approx}3.5 Multiplication-Sign 10{supmore » 10} cm and mass of {approx}0.9-2.6 M{sub Sun} imply that a significant part of the helium envelope should survive through the mass loss during the last stage of the massive progenitor of GRB 121027A.« less

CdZnTe Image Detectors for Hard-X-Ray Telescopes

NASA Technical Reports Server (NTRS)

Chen, C. M. Hubert; Cook, Walter R.; Harrison, Fiona A.; Lin, Jiao Y. Y.; Mao, Peter H.; Schindler, Stephen M.

2005-01-01

Arrays of CdZnTe photodetectors and associated electronic circuitry have been built and tested in a continuing effort to develop focal-plane image sensor systems for hard-x-ray telescopes. Each array contains 24 by 44 pixels at a pitch of 498 m. The detector designs are optimized to obtain low power demand with high spectral resolution in the photon- energy range of 5 to 100 keV. More precisely, each detector array is a hybrid of a CdZnTe photodetector array and an application-specific integrated circuit (ASIC) containing an array of amplifiers in the same pixel pattern as that of the detectors. The array is fabricated on a single crystal of CdZnTe having dimensions of 23.6 by 12.9 by 2 mm. The detector-array cathode is a monolithic platinum contact. On the anode plane, the contact metal is patterned into the aforementioned pixel array, surrounded by a guard ring that is 1 mm wide on three sides and is 0.1 mm wide on the fourth side so that two such detector arrays can be placed side-by-side to form a roughly square sensor area with minimal dead area between them. Figure 1 shows two anode patterns. One pattern features larger pixel anode contacts, with a 30-m gap between them. The other pattern features smaller pixel anode contacts plus a contact for a shaping electrode in the form of a grid that separates all the pixels. In operation, the grid is held at a potential intermediate between the cathode and anode potentials to steer electric charges toward the anode in order to reduce the loss of charges in the inter-anode gaps. The CdZnTe photodetector array is mechanically and electrically connected to the ASIC (see Figure 2), either by use of indium bump bonds or by use of conductive epoxy bumps on the CdZnTe array joined to gold bumps on the ASIC. Hence, the output of each pixel detector is fed to its own amplifier chain.

Novel First-Level Interconnect Techniques for Flip Chip on MEMS Devices

PubMed Central

Sutanto, Jemmy; Anand, Sindhu; Patel, Chetan; Muthuswamy, Jit

2013-01-01

Flip-chip packaging is desirable for microelectro-mechanical systems (MEMS) devices because it reduces the overall package size and allows scaling up the number of MEMS chips through 3-D stacks. In this report, we demonstrate three novel techniques to create first-level interconnect (FLI) on MEMS: 1) Dip and attach technology for Ag epoxy; 2) Dispense technology for solder paste; 3) Dispense, pull, and attach technology (DPAT) for solder paste. The above techniques required no additional microfabrication steps, produced no visible surface contamination on the MEMS active structures, and generated high-aspect-ratio interconnects. The developed FLIs were successfully tested on MEMS moveable microelectrodes microfabricated by SUMMiTVTM process producing no apparent detrimental effect due to outgassing. The bumping processes were successfully applied on Al-deposited bond pads of 100 μm × 100 μm with an average bump height of 101.3 μm for Ag and 184.8 μm for solder (63Sn, 37Pb). DPAT for solder paste produced bumps with the aspect ratio of 1.8 or more. The average shear strengths of Ag and solder bumps were 78 MPa and 689 kPa, respectively. The electrical test on Ag bumps at 794 A/cm2 demonstrated reliable electrical interconnects with negligible resistance. These scalable FLI technologies are potentially useful for MEMS flip-chip packaging and 3-D stacking. PMID:24504168

Effect of Joint Scale and Processing on the Fracture of Sn-3Ag-0.5Cu Solder Joints: Application to Micro-bumps in 3D Packages

NASA Astrophysics Data System (ADS)

Talebanpour, B.; Huang, Z.; Chen, Z.; Dutta, I.

2016-01-01

In 3-dimensional (3D) packages, a stack of dies is vertically connected to each other using through-silicon vias and very thin solder micro-bumps. The thinness of the micro-bumps results in joints with a very high volumetric proportion of intermetallic compounds (IMCs), rendering them much more brittle compared to conventional joints. Because of this, the reliability of micro-bumps, and the dependence thereof on the proportion of IMC in the joint, is of substantial concern. In this paper, the growth kinetics of IMCs in thin Sn-3Ag-0.5Cu joints attached to Cu substrates were analyzed, and empirical kinetic laws for the growth of Cu6Sn5 and Cu3Sn in thin joints were obtained. Modified compact mixed mode fracture mechanics samples, with adhesive solder joints between massive Cu substrates, having similar thickness and IMC content as actual micro-bumps, were produced. The effects of IMC proportion and strain rate on fracture toughness and mechanisms were investigated. It was found that the fracture toughness G C decreased with decreasing joint thickness ( h Joint). In addition, the fracture toughness decreased with increasing strain rate. Aging also promoted alternation of the crack path between the two joint-substrate interfaces, possibly proffering a mechanism to enhance fracture toughness.

A complete disclosure of the hidden type-1 AGN in NGC 1068 thanks to 52 years of broadband polarimetric observation

NASA Astrophysics Data System (ADS)

Marin, F.

2018-06-01

We create the first broadband polarization spectrum of an active galactic nucleus (AGN) by compiling the 0.1 - 100 μm, 4.9 GHz and 15 GHz continuum polarization of NGC 1068 from more than 50 years of observations. Despite the diversity of instruments and apertures, the observed spectrum of linear continuum polarization has distinctive wavelength-dependent signatures that can be related to the AGN and host galaxy physics. The impact of the Big Blue bump and infrared bump, together with electron, Mie scattering, dichroism and synchrotron emission are naturally highlighted in polarization, allowing us to reveal the type-1 AGN core inside this type-2 object with unprecedented precision. In order to isolate the AGN component, we reconstruct the spectral energy distribution of NGC 1068 and estimate the fraction of diluting light in the observed continuum flux. This allows us to clearly and independently show that, in the case of NGC 1068, Thomson scattering is the dominant mechanism for the polarization in the optical band. We also investigate the effect of aperture on the observed polarization and confirm previous findings on the extension of the narrow line region of NGC 1068 and on the B-band and K-band polarization from the host. Finally, we do not detect statistically significant aperture-corrected polarimetric variations over the last 52 years, suggesting that the parsec-scale morphological and magnetic geometries probably remained stable for more than half a century.

Low-strain laser-based solder joining of mounted lenses

NASA Astrophysics Data System (ADS)

Burkhardt, Thomas; Hornaff, Marcel; Kamm, Andreas; Burkhardt, Diana; Schmidt, Erik; Beckert, Erik; Eberhardt, Ramona; Tünnermann, Andreas

2015-09-01

A novel laser-based soldering technique - Solderjet Bumping - using liquid solder droplets in a flux-free process with only localized heating is presented. We demonstrate an all inorganic, adhesive free bonding of optical components and support structures suitable for optical assemblies and instruments under harsh environmental conditions. Low strain bonding suitable for a following high-precision adjustment turning process is presented, addressing components and subsystems for objectives for high power and short wavelengths. The discussed case study shows large aperture transmissive optics (diameter approx. 74 mm and 50 mm) made of fused silica and LAK9G15, a radiation resistant glass, bonded to thermally matched metallic mounts. The process chain of Solderjet Bumping - cleaning, solderable metallization, handling, bonding and inspection - is discussed. This multi-material approach requires numerical modelling for dimensioning according to thermal and mechanical loads. The findings of numerical modelling, process parametrization and environmental testing (thermal and vibrational loads) are presented. Stress and strain introduced into optical components as well as deformation of optical surfaces can significantly deteriorate the wave front of passing light and therefore reduce system performance significantly. The optical performance with respect to stress/strain and surface deformation during bonding and environmental testing were evaluated using noncontact and nondestructive optical techniques: polarimetry and interferometry, respectively. Stress induced surface deformation of less than 100 nm and changes in optical path difference below 5 nm were achieved. Bond strengths of about 55 MPa are reported using tin-silver-copper soft solder alloy.

[Study on the polarized reflectance-hyperspectral information fusion technology of tomato leaves nutrient diagnoses].

PubMed

Zhu, Wen-Jing; Mao, Han-Ping; Li, Qing-Lin; Liu, Hong-Yu; Sun, Jun; Zuo, Zhi-Yu; Chen, Yong

2014-09-01

With 25%, 50%, 75%, 100% and 150%, five levels of, nitrogen (N), phosphorus (P) and potassium (K) nutrition stress samples cultivated in Venlo type greenhouse soilless cultivation mode as the research object, polarized reflectance spectra and hyperspectral images of different nutrient deficiency greenhouse tomato leaves were acquired by using polarized reflectance spectroscopy system developed by our own research group and hyperspectral imaging system respectively. The relationship between a certain number of changes in the bump and texture of non-smooth surface of the nutrient stress leaf and the level of polarization reflected radiation was clarified by scanning electron microscopy (SEM). On the one hand, the polarization spectrum was converted into the degree of polarization through Stokes equation, and the four polarization characteristics between the polarization spectroscopy and reference measurement values of N, P and K respectively were extracted. On the other hand, the four characteristic wavelengths of N, P, K hyperspectral image data were determined respectively through the principal component analysis, followed by eight hyperspectral texture features extracted corresponding to the four characteristic wavelengths through correlation analysis. Polarization characteristics and hyperspectral texture features combined with each characteristics of N, P, K were extracted. These 12 characteristic variables were normalized by maximum-minimum value method. N, P, K nutrient levels quantitative diagnostic models were established by SVR. Results of models are as follows: the correlation coefficient of nitrogen r = 0.961 8, root mean square error RMSE= 0.451; correlation coefficient of phosphorus r = 0.916 3, root mean square error RMSE = 0.620; correlation coefficient of potassium r = 0.940 6, root mean square error RMSE = 0.494. The results show that high precision tomato leaves nutrition prediction model could be built by using polarized reflectance spectroscopy combined with high spectral information fusion technology and achieve good diagnoses effect. It has a great significance for the improvement of model accuracy and the development of special instruments. The research provides a new idea for the rapid detection of tomato nutrient content.

Ultra-fast Movies Resolve Ultra-short Pulse Laser Ablation and Bump Formation on Thin Molybdenum Films

NASA Astrophysics Data System (ADS)

Domke, Matthias; Rapp, Stephan; Huber, Heinz

For the monolithic serial interconnection of CIS thin film solar cells, 470 nm molybdenum films on glass substrates must be separated galvanically. The single pulse ablation with a 660 fs laser at a wavelength of 1053 nm is investigated in a fluence regime from 0.5 to 5.0 J/cm2. At fluences above 2.0 J/cm2 bump and jet formation can be observed that could be used for creating microstructures. For the investigation of the underlying mechanisms of the laser ablation process itself as well as of the bump or jet formation, pump probe microscopy is utilized to resolve the transient ablation behavior.

Ultrasmooth Patterned Metals for Plasmonics and Metamaterials

NASA Astrophysics Data System (ADS)

Nagpal, Prashant; Lindquist, Nathan C.; Oh, Sang-Hyun; Norris, David J.

2009-07-01

Surface plasmons are electromagnetic waves that can exist at metal interfaces because of coupling between light and free electrons. Restricted to travel along the interface, these waves can be channeled, concentrated, or otherwise manipulated by surface patterning. However, because surface roughness and other inhomogeneities have so far limited surface-plasmon propagation in real plasmonic devices, simple high-throughput methods are needed to fabricate high-quality patterned metals. We combined template stripping with precisely patterned silicon substrates to obtain ultrasmooth pure metal films with grooves, bumps, pyramids, ridges, and holes. Measured surface-plasmon-propagation lengths on the resulting surfaces approach theoretical values for perfectly flat films. With the use of our method, we demonstrated structures that exhibit Raman scattering enhancements above 107 for sensing applications and multilayer films for optical metamaterials.

Reading in Middle School: Bumps in the Literacy Crossroads

ERIC Educational Resources Information Center

Hall, Katrina Willard

2008-01-01

Certainly a major bump in the literacy road today is the apparent conflict between school literacies and the preferred literacy activities of students outside of school. After family conversation about a nephew who was getting poor grades in language arts, Hall shares her thinking on the dilemmas of what constitutes literacy, how literacies kids…

3D Printing of Ball Grid Arrays

NASA Astrophysics Data System (ADS)

Sinha, Shayandev; Hines, Daniel; Dasgupta, Abhijit; Das, Siddhartha

Ball grid arrays (BGA) are interconnects between an integrated circuit (IC) and a printed circuit board (PCB), that are used for surface mounting electronic components. Typically, lead free alloys are used to make solder balls which, after a reflow process, establish a mechanical and electrical connection between the IC and the PCB. High temperature processing is required for most of these alloys leading to thermal shock causing damage to ICs. For producing flexible circuits on a polymer substrate, there is a requirement for low temperature processing capabilities (around 150 C) and for reducing strain from mechanical stresses. Additive manufacturing techniques can provide an alternative methodology for fabricating BGAs as a direct replacement for standard solder bumped BGAs. We have developed aerosol jet (AJ) printing methods to fabricate a polymer bumped BGA. As a demonstration of the process developed, a daisy chain test chip was polymer bumped using an AJ printed ultra violet (UV) curable polymer ink that was then coated with an AJ printed silver nanoparticle laden ink as a conducting layer printed over the polymer bump. The structure for the balls were achieved by printing the polymer ink using a specific toolpath coupled with in-situ UV curing of the polymer which provided good control over the shape, resulting in well-formed spherical bumps on the order of 200 um wide by 200 um tall for this initial demonstration. A detailed discussion of the AJ printing method and results from accelerated life-time testing will be presented

Location-Control of Large Si Grains by Dual-Beam Excimer-Laser and Thick Oxide Portion

NASA Astrophysics Data System (ADS)

Ishihara, Ryoichi; Burtsev, Artyom; Alkemade, Paul F. A.

2000-07-01

An array of large Si grains was placed at a predetermined position by dual excimer-laser irradiation of a multi-layer structure of silicon (Si), silicon dioxide (SiO2) with an array of bumps and metal on a glass substrate. We have investigated the effects of irradiating energy density and the topology of the structure on the grain size and crystallographic structure by scanning electron microscopy (SEM) and electron back-scattering pattern (EBSP) analysis. In the low-energy-density regime, numerous small grains and petal shaped grains formed on top of the SiO2 bumps. The number of small grains on the bumps decreased with increasing irradiating energy density. At sufficiently high energy densities, one single Si grain as large as 3.5 μm was positioned at the center of the bumps. Although most of the area of the large Si grain has a single crystallographic orientation, twins and low-angle grain boundaries are often formed at the periphery of the grain. There was no preferred crystallographic orientation in the center of the location-controlled Si grain. Numerical analysis of the temperature profile showed that a temperature drop occurs at the center of the bump, during and immediately after laser irradiation. The diameter of the location-controlled Si grain increased with total thickness of the intermediate SiO2 layer, and took the maximum value of 6.2 μm.

Supercritical fluid extraction of selected pharmaceuticals from water and serum.

PubMed

Simmons, B R; Stewart, J T

1997-01-24

Selected drugs from benzodiazepine, anabolic agent and non-steroidal anti-inflammatory drug (NSAID) therapeutic classes were extracted from water and serum using a supercritical CO2 mobile phase. The samples were extracted at a pump pressure of 329 MPa, an extraction chamber temperature of 45 degrees C, and a restrictor temperature of 60 degrees C. The static extraction time for all samples was 2.5 min and the dynamic extraction time ranged from 5 to 20 min. The analytes were collected in appropriate solvent traps and assayed by modified literature HPLC procedures. Analyte recoveries were calculated based on peak height measurements of extracted vs. unextracted analyte. The recovery of the benzodiazepines ranged from 80 to 98% in water and from 75 to 94% in serum. Anabolic drug recoveries from water and serum ranged from 67 to 100% and 70 to 100%, respectively. The NSAIDs were recovered from water in the 76 to 97% range and in the 76 to 100% range from serum. Accuracy, precision and endogenous peak interference, if any, were determined for blank and spiked serum extractions and compared with classical sample preparation techniques of liquid-liquid and solid-phase extraction reported in the literature. For the benzodiazepines, accuracy and precision for supercritical fluid extraction (SFE) ranged from 1.95 to 3.31 and 0.57 to 1.25%, respectively (n = 3). The SFE accuracy and precision data for the anabolic agents ranged from 4.03 to 7.84 and 0.66 to 2.78%, respectively (n = 3). The accuracy and precision data reported for the SFE of the NSAIDs ranged from 2.79 to 3.79 and 0.33 to 1.27%, respectively (n = 3). The precision of the SFE method from serum was shown to be comparable to the precision obtained with other classical preparation techniques.

High-order integral equation methods for problems of scattering by bumps and cavities on half-planes.

PubMed

Pérez-Arancibia, Carlos; Bruno, Oscar P

2014-08-01

This paper presents high-order integral equation methods for the evaluation of electromagnetic wave scattering by dielectric bumps and dielectric cavities on perfectly conducting or dielectric half-planes. In detail, the algorithms introduced in this paper apply to eight classical scattering problems, namely, scattering by a dielectric bump on a perfectly conducting or a dielectric half-plane, and scattering by a filled, overfilled, or void dielectric cavity on a perfectly conducting or a dielectric half-plane. In all cases field representations based on single-layer potentials for appropriately chosen Green functions are used. The numerical far fields and near fields exhibit excellent convergence as discretizations are refined-even at and around points where singular fields and infinite currents exist.

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

PubMed

Van Voorhis, Wesley C; Doggett, J Stone; Parsons, Marilyn; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Riggs, Michael W; Hemphill, Andrew; Howe, Daniel K; Mealey, Robert H; Lau, Audrey O T; Merritt, Ethan A; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K

2017-09-01

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium-dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites' survival and proliferation. In this article, we review efficacy against the kinase target, parasite growth in vitro, and in animal infection models, as well as the relevant pharmacokinetic and safety parameters of bumped kinase inhibitors. Copyright © 2017 Elsevier Inc. All rights reserved.

The physics of bump drafting in car racing

NASA Astrophysics Data System (ADS)

Fiolhais, Miguel C. N.; Amor dos Santos, Susana

2014-11-01

The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the physics of drag in moving vehicles. In the context of a physics undergraduate course, it is shown that the dynamics of two moving cars in the same air slipstream on a straight line allows them to increase their speed up to a factor of \\sqrt{2} . This conclusion is also extended to an arbitrary number of n identical moving cars, resulting in an increase of \\sqrt{n} .

CFD-Predicted Tile Heating Bump Factors Due to Tile Overlay Repairs

NASA Technical Reports Server (NTRS)

Lessard, Victor R.

2006-01-01

A Computational Fluid Dynamics investigation of the Orbiter's Tile Overlay Repair (TOR) is performed to assess the aeroheating Damage Assessment Team's (DAT) existing heating correlation method for protuberance interference heating on the surrounding thermal protection system. Aerothermodynamic heating analyses are performed for TORs at the design reference damage locations body points 1800 and 1075 for a Mach 17.9 and a=39deg STS-107 flight trajectory point with laminar flow. Six different cases are considered. The computed peak heating bump factor on the surrounding tiles are below the DAT's heating bump factor values for smooth tile cases. However, for the uneven tiles cases the peak interference heating is shown to be considerably higher than the existing correlation prediction.

Interstellar Silicon Depletion and the Ultraviolet Extinction

NASA Astrophysics Data System (ADS)

Mishra, Ajay; Li, Aigen

2018-01-01

Spinning small silicate grains were recently invoked to account for the Galactic foreground anomalous microwave emission. These grains, if present, will absorb starlight in the far ultraviolet (UV). There is also renewed interest in attributing the enigmatic 2175 Å interstellar extinction bump to small silicates. To probe the role of silicon in the UV extinction, we explore the relations between the amount of silicon required to be locked up in silicates [Si/H]dust and the 2175 Å bump or the far-UV extinction rise, based on an analysis of the extinction curves along 46 Galactic sightlines for which the gas-phase silicon abundance [Si/H]gas is known. We derive [Si/H]dust either from [Si/H]ISM - [Si/H]gas or from the Kramers- Kronig relation which relates the wavelength-integrated extinction to the total dust volume, where [Si/H]ISM is the interstellar silicon reference abundance and taken to be that of proto-Sun or B stars. We also derive [Si/H]dust from fi�tting the observed extinction curves with a mixture of amorphous silicates and graphitic grains. We fi�nd that in all three cases [Si/H]dust shows no correlation with the 2175 Å bump, while the carbon depletion [C/H]dust tends to correlate with the 2175 Å bump. This supports carbon grains instead of silicates as the possible carrier of the 2175 Å bump. We also �find that neither [Si/H]dust nor [C/H]dust alone correlates with the far-UV extinction, suggesting that the far-UV extinction is a combined effect of small carbon grains and silicates.

Interstellar Silicon Depletion and the Ultraviolet Extinction

NASA Astrophysics Data System (ADS)

Mishra, Ajay; Li, Aigen

2017-12-01

Spinning small silicate grains were recently invoked to account for the Galactic foreground anomalous microwave emission. These grains, if present, will absorb starlight in the far-ultraviolet (UV). There is also renewed interest in attributing the enigmatic 2175 \\mathringA interstellar extinction bump to small silicates. To probe the role of silicon in the UV extinction, we explore the relations between the amount of silicon required to be locked up in silicates {[{Si}/{{H}}]}{dust} and the 2175 \\mathringA bump or the far-UV extinction rise, based on an analysis of the extinction curves along 46 Galactic sightlines for which the gas-phase silicon abundance {[{Si}/{{H}}]}{gas} is known. We derive {[{Si}/{{H}}]}{dust} either from {[{Si}/{{H}}]}{ISM}‑{[{Si}/{{H}}]}{gas} or from the Kramers–Kronig relation, which relates the wavelength-integrated extinction to the total dust volume, where {[{Si}/{{H}}]}{ISM} is the interstellar silicon reference abundance and taken to be that of proto-Sun or B stars. We also derive {[{Si}/{{H}}]}{dust} from fitting the observed extinction curves with a mixture of amorphous silicates and graphitic grains. We find that in all three cases {[{Si}/{{H}}]}{dust} shows no correlation with the 2175 \\mathringA bump, while the carbon depletion {[{{C}}/{{H}}]}{dust} tends to correlate with the 2175 \\mathringA bump. This supports carbon grains instead of silicates as the possible carriers of the 2175 \\mathringA bump. We also find that neither {[{Si}/{{H}}]}{dust} nor {[{{C}}/{{H}}]}{dust} alone correlates with the far-UV extinction, suggesting that the far-UV extinction is a combined effect of small carbon grains and silicates.

Qualification test report bump protection hat (subassembly of T020/M509 head protective assembly)

NASA Technical Reports Server (NTRS)

Willis, D. B.

1972-01-01

The bump protection hat (BPH) was subjected to impact testing in which it underwent three impacts at 35 foot-pounds of energy. The impacts generated stress cracks, but no penetration. All impacts resulted in deflections of less than one-half inch. It was shown that the BPH is qualified for Skylab and the rescue vehicle.

Does everything happen when you are young? Introducing the youth bias.

PubMed

Koppel, Jonathan; Berntsen, Dorthe

2014-01-01

The reminiscence bump refers to the disproportionate number of individuals' autobiographical memories that date from young adulthood. A similar bump is found in cultural life scripts: When people are asked to nominate and date major transitional events in a typical life course in their culture, a disproportionate number of the events cited are likewise expected to occur in young adulthood. Across two online studies, we tested whether these effects reflect a broader tendency to ascribe most important events to young adulthood. Specifically, we probed, in adult USA samples, for when individuals expect the most important public event of a typical person's life to take place. Although the occurrence of such public events should be randomly distributed across the lifespan, we found a bump in young adulthood. We found this bump in both subjective (Study 1; probing cultural expectations for the expected timing of the public event that a typical person considers to be the most important of their lifetime) and objective (Study 2; probing cultural expectations for the expected timing of the objectively most important public event of a typical person's lifetime) conditions. We term this set of cultural expectations the youth bias and discuss its implications for human cognition.

New Failure Mode of Flip-Chip Solder Joints Related to the Metallization of an Organic Substrate

NASA Astrophysics Data System (ADS)

Jang, J. W.; Yoo, S. J.; Hwang, H. I.; Yuk, S. Y.; Kim, C. K.; Kim, S. J.; Han, J. S.; An, S. H.

2015-10-01

We report a new failure phenomenon during flip-chip die attach. After reflow, flip-chip bumps were separated between the Al and Ti layers on the Si die side. This was mainly observed at the Si die corner. Transmission electron microscopy images revealed corrosion of the Al layer at the edge of the solder bump metallization. The corrosion at the metallization edge exhibited a notch shape with high stress concentration factor. The organic substrate had Cu metallization with an organic solderable preservative (OSP) coating layer, where a small amount of Cl ions were detected. A solder bump separation mechanism is suggested based on the reaction between Al and Cl, related to the flow of soldering flux. During reflow, the flux will dissolve the Cl-containing OSP layer and flow up to the Al layer on the Si die side. Then, the Cl-dissolved flux will actively react with Al, forming AlCl3. During cooling, solder bumps at the Si die corner will separate through the location of Al corrosion. This demonstrated that the chemistry of the substrate metallization can affect the thermomechanical reliability of flip-chip solder joints.

Application of the adjoint optimisation of shock control bump for ONERA-M6 wing

NASA Astrophysics Data System (ADS)

Nejati, A.; Mazaheri, K.

2017-11-01

This article is devoted to the numerical investigation of the shock wave/boundary layer interaction (SWBLI) as the main factor influencing the aerodynamic performance of transonic bumped airfoils and wings. The numerical analysis is conducted for the ONERA-M6 wing through a shock control bump (SCB) shape optimisation process using the adjoint optimisation method. SWBLI is analyzed for both clean and bumped airfoils and wings, and it is shown how the modified wave structure originating from upstream of the SCB reduces the wave drag, by improving the boundary layer velocity profile downstream of the shock wave. The numerical simulation of the turbulent viscous flow and a gradient-based adjoint algorithm are used to find the optimum location and shape of the SCB for the ONERA-M6 airfoil and wing. Two different geometrical models are introduced for the 3D SCB, one with linear variations, and another with periodic variations. Both configurations result in drag reduction and improvement in the aerodynamic efficiency, but the periodic model is more effective. Although the three-dimensional flow structure involves much more complexities, the overall results are shown to be similar to the two-dimensional case.

A Pulsar Wind Nebula Model Applied to Short GRB 050724

NASA Astrophysics Data System (ADS)

Lin, Wei-Li; Wang, Ling-Jun; Dai, Zi-Gao

2018-03-01

A subset of short gamma-ray bursts (sGRBs) have been found to be characterized by near-infrared/optical bumps at ∼1 days, some of which exhibit almost concurrent X-ray flares. Although the near-infrared/optical bumps may be a signature of kilonovae, the X-ray flares are not consistent with kilonovae. It is widely believed that sGRBs are produced by the mergers of double compact objects, during which sub-relativistic ejecta are launched. In this paper, we propose that the above optical/X-ray features are indicative of the formation of long-lived magnetars following the mergers of double neutron stars. Observations and theoretical works imply that the spin-down power of the magnetars is injected into the ejecta as ultra-relativistic electron–positron pairs, i.e., pulsar wind nebulae (PWNe). Here, we suggest such a PWN model and find that the optical bump and X-ray flare observed in GRB 050724 can be well understood in this PWN model. We show that the optical bump and X-ray flare may have different origins. Our results strengthen the evidence for the formation of magnetars in double neutron star mergers and justify the validity of the PWN model.

LINEAR AND NONLINEAR CORRECTIONS IN THE RHIC INTERACTION REGIONS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

PILAT,F.; CAMERON,P.; PTITSYN,V.

2002-06-02

A method has been developed to measure operationally the linear and non-linear effects of the interaction region triplets, that gives access to the multipole content through the action kick, by applying closed orbit bumps and analysing tune and orbit shifts. This technique has been extensively tested and used during the RHIC operations in 2001. Measurements were taken at 3 different interaction regions and for different focusing at the interaction point. Non-linear effects up to the dodecapole have been measured as well as the effects of linear, sextupolar and octupolar corrections. An analysis package for the data processing has been developedmore » that through a precise fit of the experimental tune shift data (measured by a phase lock loop technique to better than 10{sup -5} resolution) determines the multipole content of an IR triplet.« less

Geometrical and Structural Asperities on Fault Surfaces

NASA Astrophysics Data System (ADS)

Sagy, A.; Brodsky, E. E.; van der Elst, N.; Agosta, F.; di Toro, G.; Collettini, C.

2007-12-01

Earthquake dynamics are strongly affected by fault zone structure and geometry. Fault surface irregularities and the nearby structure control the rupture nucleation and propagation, the fault strength, the near-field stress orientations and the hydraulic properties. New field observations demonstrate the existence of asperities in faults as displayed by topographical bumps on the fault surface and hardening of the internal structure near them. Ground-based LIDAR measurements on more than 30 normal and strike slip faults in different lithologies demonstrate that faults are not planar surfaces and roughness is strongly dependent on fault displacement. In addition to the well-understood roughness exemplified by abrasive striations and fracture segmentation, we found semi-elliptical topographical bumps with wavelengths of a few meters. In many faults the bumps are not spread equally on the surface and zones can be bumpier than others. The bumps are most easily identified on faults with total displacement of dozens to hundreds of meters. Smaller scale roughness on these faults is smoothed by abrasive processes. A key site in southern Oregon shows that the topographic bumps are closely tied to the internal structure of the fault zone. At this location, we combine LiDAR data with detailed structural analysis of the fault zone embedded in volcanic rocks. Here the bumps correlate with an abrupt change in the width of the cohesive cataclasite layer that is exposed under a thin ultracataclasite zone. In most of the exposures the cohesive layer thickness is 10-20 cm. However, under protruding bumps the layer is always thickened and the width can locally exceed one meter. Field and microscopic analyses show that the layer contains grains with dimensions ranging from less than 10 μ up to a few centimeters. There is clear evidence of internal flow, rotation and fracturing of the grains in the layer. X-Ray diffraction measurements of samples from the layer show that the bulk mineralogy is identical to that of the host rock, although thin section analysis suggests that some alteration and secondary mineralization of the grains also occurs. We infer that the cohesiveness of the layer is a consequence of repacking and cementation similar to deformation bands in granular material. By comparing the thickness of the cohesive layer on several secondary faults in this fault area we found that the average thickness of the layer increases with total slip. The correlation is nonlinear and the thickening rate decreases with increasing slip. We conclude that granular flow decreasing with increasing slip and thus the deformation is continually localized.

Bumps in river profiles: uncertainty assessment and smoothing using quantile regression techniques

NASA Astrophysics Data System (ADS)

Schwanghart, Wolfgang; Scherler, Dirk

2017-12-01

The analysis of longitudinal river profiles is an important tool for studying landscape evolution. However, characterizing river profiles based on digital elevation models (DEMs) suffers from errors and artifacts that particularly prevail along valley bottoms. The aim of this study is to characterize uncertainties that arise from the analysis of river profiles derived from different, near-globally available DEMs. We devised new algorithms - quantile carving and the CRS algorithm - that rely on quantile regression to enable hydrological correction and the uncertainty quantification of river profiles. We find that globally available DEMs commonly overestimate river elevations in steep topography. The distributions of elevation errors become increasingly wider and right skewed if adjacent hillslope gradients are steep. Our analysis indicates that the AW3D DEM has the highest precision and lowest bias for the analysis of river profiles in mountainous topography. The new 12 m resolution TanDEM-X DEM has a very low precision, most likely due to the combined effect of steep valley walls and the presence of water surfaces in valley bottoms. Compared to the conventional approaches of carving and filling, we find that our new approach is able to reduce the elevation bias and errors in longitudinal river profiles.

Recent versus Remote: Flashbulb Memory for 9/11 and Self-Selected Events from the Reminiscence Bump

ERIC Educational Resources Information Center

Denver, Jenny Y.; Lane, Sean M.; Cherry, Katie E.

2010-01-01

In two related studies, we examined flashbulb memories acquired from different points in the lifespan in younger and older adults. When asked to remember flashbulb memories from their lives, older adults were most likely to recall events from the reminiscence bump (Study 1A). In Study 1B, younger and older adults recalled 9/11 and a personal…

New results on diamond pixel sensors using ATLAS frontend electronics

NASA Astrophysics Data System (ADS)

Keil, M.; Adam, W.; Berdermann, E.; Bergonzo, P.; de Boer, W.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; D'Angelo, P.; Dabrowski, W.; Delpierre, P.; Dulinski, W.; Doroshenko, J.; Doucet, M.; van Eijk, B.; Fallou, A.; Fischer, P.; Fizzotti, F.; Kania, D.; Gan, K. K.; Grigoriev, E.; Hallewell, G.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kaplon, J.; Kass, R.; Knöpfle, K. T.; Koeth, T.; Krammer, M.; Logiudice, A.; mac Lynne, L.; Manfredotti, C.; Meier, D.; Menichelli, D.; Meuser, S.; Mishina, M.; Moroni, L.; Noomen, J.; Oh, A.; Pan, L. S.; Pernicka, M.; Perera, L.; Riester, J. L.; Roe, S.; Rudge, A.; Russ, J.; Sala, S.; Sampietro, M.; Schnetzer, S.; Sciortino, S.; Stelzer, H.; Stone, R.; Suter, B.; Trischuk, W.; Tromson, D.; Vittone, E.; Weilhammer, P.; Wermes, N.; Wetstein, M.; Zeuner, W.; Zoeller, M.

2003-03-01

Diamond is a promising sensor material for future collider experiments due to its radiation hardness. Diamond pixel sensors have been bump bonded to an ATLAS pixel readout chip using PbSn solder bumps. Single chip devices have been characterised by lab measurements and in a high-energy pion beam at CERN. Results on charge collection, spatial resolution, efficiency and the charge carrier lifetime are presented.

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.

PubMed

Ojo, Kayode K; Dangoudoubiyam, Sriveny; Verma, Shiv K; Scheele, Suzanne; DeRocher, Amy E; Yeargan, Michelle; Choi, Ryan; Smith, Tess R; Rivas, Kasey L; Hulverson, Matthew A; Barrett, Lynn K; Fan, Erkang; Maly, Dustin J; Parsons, Marilyn; Dubey, Jitender P; Howe, Daniel K; Van Voorhis, Wesley C

2016-12-01

Sarcocystis neurona is the most frequent cause of equine protozoal myeloencephalitis, a debilitating neurological disease of horses that can be difficult to treat. We identified SnCDPK1, the S. neurona homologue of calcium-dependent protein kinase 1 (CDPK1), a validated drug target in Toxoplasma gondii. SnCDPK1 shares the glycine "gatekeeper" residue of the well-characterized T. gondii enzyme, which allows the latter to be targeted by bumped kinase inhibitors. This study presents detailed molecular and phenotypic evidence that SnCDPK1 can be targeted for rational drug development. Recombinant SnCDPK1 was tested against four bumped kinase inhibitors shown to potently inhibit both T. gondii (Tg) CDPK1 and T. gondii tachyzoite growth. SnCDPK1 was inhibited by low nanomolar concentrations of these BKIs and S. neurona growth was inhibited at 40-120nM concentrations. Thermal shift assays confirmed these bumped kinase inhibitors bind CDPK1 in S. neurona cell lysates. Treatment with bumped kinase inhibitors before or after invasion suggests that bumped kinase inhibitors interfere with S. neurona mammalian host cell invasion in the 0.5-2.5μM range but interfere with intracellular division at 2.5μM. In vivo proof-of-concept experiments were performed in a murine model of S. neurona infection. The experimental infected groups treated for 30days with compound BKI-1553 (n=10 mice) had no signs of disease, while the infected control group had severe signs and symptoms of infection. Elevated antibody responses were found in 100% of control infected animals, but only 20% of BKI-1553 treated infected animals. Parasites were found in brain tissues of 100% of the control infected animals, but only in 10% of the BKI-1553 treated animals. The bumped kinase inhibitors used in these assays have been chemically optimized for potency, selectivity and pharmacokinetic properties, and hence are good candidates for treatment of equine protozoal myeloencephalitis. Copyright © 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

Dust Attenuation Curves in the Local Universe: Demographics and New Laws for Star-forming Galaxies and High-redshift Analogs

NASA Astrophysics Data System (ADS)

Salim, Samir; Boquien, Médéric; Lee, Janice C.

2018-05-01

We study the dust attenuation curves of 230,000 individual galaxies in the local universe, ranging from quiescent to intensely star-forming systems, using GALEX, SDSS, and WISE photometry calibrated on the Herschel ATLAS. We use a new method of constraining SED fits with infrared luminosity (SED+LIR fitting), and parameterized attenuation curves determined with the CIGALE SED-fitting code. Attenuation curve slopes and UV bump strengths are reasonably well constrained independently from one another. We find that {A}λ /{A}V attenuation curves exhibit a very wide range of slopes that are on average as steep as the curve slope of the Small Magellanic Cloud (SMC). The slope is a strong function of optical opacity. Opaque galaxies have shallower curves—in agreement with recent radiative transfer models. The dependence of slopes on the opacity produces an apparent dependence on stellar mass: more massive galaxies have shallower slopes. Attenuation curves exhibit a wide range of UV bump amplitudes, from none to Milky Way (MW)-like, with an average strength one-third that of the MW bump. Notably, local analogs of high-redshift galaxies have an average curve that is somewhat steeper than the SMC curve, with a modest UV bump that can be, to first order, ignored, as its effect on the near-UV magnitude is 0.1 mag. Neither the slopes nor the strengths of the UV bump depend on gas-phase metallicity. Functional forms for attenuation laws are presented for normal star-forming galaxies, high-z analogs, and quiescent galaxies. We release the catalog of associated star formation rates and stellar masses (GALEX–SDSS–WISE Legacy Catalog 2).

A TALE OF TWO MYSTERIES IN INTERSTELLAR ASTROPHYSICS: THE 2175 A EXTINCTION BUMP AND DIFFUSE INTERSTELLAR BANDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiang, F. Y.; Zhong, J. X.; Li Aigen, E-mail: jxzhong@xtu.edu.cn, E-mail: lia@missouri.edu

2011-06-01

The diffuse interstellar bands (DIBs) are ubiquitous absorption spectral features arising from the tenuous material in the space between stars-the interstellar medium (ISM). Since their first detection nearly nine decades ago, over 400 DIBs have been observed in the visible and near-infrared wavelength range in both the Milky Way and external galaxies, both nearby and distant. However, the identity of the species responsible for these bands remains as one of the most enigmatic mysteries in astrophysics. An equally mysterious interstellar spectral signature is the 2175 A extinction bump, the strongest absorption feature observed in the ISM. Its carrier also remainsmore » unclear since its first detection 46 years ago. Polycyclic aromatic hydrocarbon (PAH) molecules have long been proposed as a candidate for DIBs as their electronic transitions occur in the wavelength range where DIBs are often found. In recent years, the 2175 A extinction bump is also often attributed to the {pi}-{pi}* transition in PAHs. If PAHs are indeed responsible for both the 2175 A extinction feature and DIBs, their strengths may correlate. We perform an extensive literature search for lines of sight for which both the 2175 A extinction feature and DIBs have been measured. Unfortunately, we found no correlation between the strength of the 2175 A feature and the equivalent widths of the strongest DIBs. A possible explanation might be that DIBs are produced by small free gas-phase PAH molecules and ions, while the 2175 A bump is mainly from large PAHs or PAH clusters in condensed phase so that there is no tight correlation between DIBs and the 2175 A bump.« less

Transforming in-situ observations of CME-driven shock accelerated protons into the shock's reference frame.

NASA Astrophysics Data System (ADS)

Robinson, I. M.; Simnett, G. M.

2005-07-01

We examine the solar energetic particle event following solar activity from 14, 15 April 2001 which includes a "bump-on-the-tail" in the proton energy spectra at 0.99 AU from the Sun. We find this population was generated by a CME-driven shock which arrived at 0.99 AU around midnight 18 April. As such this population represents an excellent opportunity to study in isolation, the effects of proton acceleration by the shock. The peak energy of the bump-on-the-tail evolves to progressively lower energies as the shock approaches the observing spacecraft at the inner Lagrange point. Focusing on the evolution of this peak energy we demonstrate a technique which transforms these in-situ spectral observations into a frame of reference co-moving with the shock whilst making allowance for the effects of pitch angle scattering and focusing. The results of this transform suggest the bump-on-the-tail population was not driven by the 15 April activity but was generated or at least modulated by a CME-driven shock which left the Sun on 14 April. The existence of a bump-on-the-tail population is predicted by models in Rice et al. (2003) and Li et al. (2003) which we compare with observations and the results of our analysis in the context of both the 14 April and 15 April CMEs. We find an origin of the bump-on-the-tail at the 14 April CME-driven shock provides better agreement with these modelled predictions although some discrepancy exists as to the shock's ability to accelerate 100 MeV protons. Keywords. Solar physics, astrophysics and astronomy (Energetic particles; Flares and mass ejections) Space plasma physics (Transport processes)

Light curves for bump Cepheids computed with a dynamically zoned pulsation code

NASA Technical Reports Server (NTRS)

Adams, T. F.; Castor, J. I.; Davis, C. G.

1980-01-01

The dynamically zoned pulsation code developed by Castor, Davis, and Davison was used to recalculate the Goddard model and to calculate three other Cepheid models with the same period (9.8 days). This family of models shows how the bumps and other features of the light and velocity curves change as the mass is varied at constant period. The use of a code that is capable of producing reliable light curves demonstrates that the light and velocity curves for 9.8 day Cepheid models with standard homogeneous compositions do not show bumps like those that are observed unless the mass is significantly lower than the 'evolutionary mass.' The light and velocity curves for the Goddard model presented here are similar to those computed independently by Fischel, Sparks, and Karp. They should be useful as standards for future investigators.

NEOS Data and the Origin of the 5 MeV Bump in the Reactor Antineutrino Spectrum

NASA Astrophysics Data System (ADS)

Huber, Patrick

2017-01-01

We perform a combined analysis of recent NEOS and Daya Bay data on the reactor antineutrino spectrum. This analysis includes approximately 1.5 million antineutrino events, which is the largest neutrino event sample analyzed to date. We use a double ratio which cancels flux model dependence and related uncertainties as well as the effects of the detector response model. We find at 3-4 standard deviation significance level, that plutonium-239 and plutonium-241 are disfavored as the single source for the so-called 5 MeV bump. This analysis method has general applicability and, in particular, with higher statistics data sets, will be able to shed significant light on the issue of the bump. With some caveats, this should also allow us to improve the sensitivity for sterile neutrino searches in NEOS.

YIP: Generic Environment Models (GEMs) for Agile Marine Autonomy

DTIC Science & Technology

2013-09-30

2012, and spring 2013, SC for a related NSF project: “Mechanisms of nutrient input at the shelf margin supporting persistent winter phytoplankton blooms...the Shelf Margin Supporting Persistent Winter Phytoplankton Blooms Downstream of the Charleston Bump. We will deploy underwater gliders in Long Bay...SC to study mechanisms of nutrient input at the shelf margin supporting persistent winter phytoplankton blooms downstream of the Charleston Bump. GEM

Detection of solder bump defects on a flip chip using vibration analysis

NASA Astrophysics Data System (ADS)

Liu, Junchao; Shi, Tielin; Xia, Qi; Liao, Guanglan

2012-03-01

Flip chips are widely used in microelectronics packaging owing to the high demand of integration in IC fabrication. Solder bump defects on flip chips are difficult to detect, because the solder bumps are obscured by the chip and substrate. In this paper a nondestructive detection method combining ultrasonic excitation with vibration analysis is presented for detecting missing solder bumps, which is a typical defect in flip chip packaging. The flip chip analytical model is revised by considering the influence of spring mass on mechanical energy of the system. This revised model is then applied to estimate the flip chip resonance frequencies. We use an integrated signal generator and power amplifier together with an air-coupled ultrasonic transducer to excite the flip chips. The vibrations are measured by a laser scanning vibrometer to detect the resonance frequencies. A sensitivity coefficient is proposed to select the sensitive resonance frequency order for defect detection. Finite element simulation is also implemented for further investigation. The results of analytical computation, experiment, and simulation prove the efficacy of the revised flip chip analytical model and verify the effectiveness of this detection method. Therefore, it may provide a guide for the improvement and innovation of the flip chip on-line inspection systems.

Synaptic efficacy shapes resource limitations in working memory.

PubMed

Krishnan, Nikhil; Poll, Daniel B; Kilpatrick, Zachary P

2018-06-01

Working memory (WM) is limited in its temporal length and capacity. Classic conceptions of WM capacity assume the system possesses a finite number of slots, but recent evidence suggests WM may be a continuous resource. Resource models typically assume there is no hard upper bound on the number of items that can be stored, but WM fidelity decreases with the number of items. We analyze a neural field model of multi-item WM that associates each item with the location of a bump in a finite spatial domain, considering items that span a one-dimensional continuous feature space. Our analysis relates the neural architecture of the network to accumulated errors and capacity limitations arising during the delay period of a multi-item WM task. Networks with stronger synapses support wider bumps that interact more, whereas networks with weaker synapses support narrower bumps that are more susceptible to noise perturbations. There is an optimal synaptic strength that both limits bump interaction events and the effects of noise perturbations. This optimum shifts to weaker synapses as the number of items stored in the network is increased. Our model not only provides a circuit-based explanation for WM capacity, but also speaks to how capacity relates to the arrangement of stored items in a feature space.

High precision measurement of the proton charge radius: The PRad experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meziane, Mehdi

2013-11-01

The recent high precision measurements of the proton charge radius performed at PSI from muonic hydrogen Lamb shift puzzled the hadronic physics community. A value of 0.8418 {+-} 0.0007 fm was extracted which is 7{sigma} smaller than the previous determinations obtained from electron-proton scattering experiments and based on precision spectroscopy of electronic hydrogen. An additional extraction of the proton charge radius from electron scattering at Mainz is also in good agreement with these "electronic" determinations. An independent measurement of the proton charge radius from unpolarized elastic ep scattering using a magnetic spectrometer free method was proposed and fully approved atmore » Jefferson Laboratory in June 2012. This novel technique uses the high precision calorimeter HyCal and a windowless hydrogen gas target which makes possible the extraction of the charge radius at very forward angles and thus very low momentum transfer Q{sup 2} up to 10{sup -4} (GeV/c){sup 2} with an unprecedented sub-percent precision for this type of experiment. In this paper, after a review of the recent progress on the proton charge radius extraction and the new high precision experiment PRad will be presented.« less

Coal mine bumps as related to geologic features in the northern part of the Sunnyside District, Carbon County, Utah

USGS Publications Warehouse

Osterwald, Frank W.; Dunrud, C. Richard; Collins, Donley S.

1993-01-01

Coal mine bumps, which are violent, spontaneous, and often catastrophic disruptions of coal and rock, were common in the Sunnyside coal mining district, Utah, before the introduction of protective-engineering methods, modern room-and-pillar retreat mining with continuous mining machines, and particularly modern longwall mining. The coal at Sunnyside, when stressed during mining, fails continuously with many popping, snapping, and banging noises. Although most of the bumps are beneficial because they make mining easier, many of the large ones are dangerous and in the past caused injuries and fatalities, particularly with room- and-pillar mining methods used in the early mining operations. Geologic mapping of underground mine openings revealed many types of deformational features, some pre-mine and some post-mine in age. Stresses resulting from mining are concentrated near the mine openings; if openings are driven at large angles to small pre-mine deformational features, particularly shatter zones in coal, abnormal stress buildups may occur and violent bumps may result. Other geologic features, such as ripple marks, oriented sand grains, intertongued rock contacts, trace fossils, and load casts, also influence the occurrence of bumps by impeding slip of coal and rocks along bedding planes. The stress field in the coal also varies markedly because of the rough ridge and canyon topography. These features may allow excessively large stress components to accumulate. At many places, the stresses that contribute to deformation and failures of mine openings are oriented horizontally. The stratigraphy of the rocks immediately above and below the mined coal bed strongly influences the deformation of the mine openings in response to stress accumulations. Triaxial compressive testing of coal from the Sunnyside No.1 and No.3 Mines indicates that the strength of the coal increases several times as the confining (lateral) stress is increased. Strengths of cores cut from single large blocks of coal vary widely. Although the strengths of coal cores increase slowly at high levels of confining stress, the coal in Sunnyside No. 1 Mine is slightly stronger in laboratory tests than coal in Sunnyside No.3 Mine. The coal in No.1 Mine probably can store larger amounts of stress than coal in the No.3 Mine, which may account for the apparently greater number of violent bumps in No.1 Mine. The strength of coal, and its ability to store stress before failure, may correlate in part with chemical composition, particularly with the amounts of benzene ring compounds in vitrain; coal with relatively large amounts of benzene ring compounds is stronger than coal with lesser amounts of these compounds. Alternatively, the chemical composition of coal may affect its response to stress. Increasing contents of kaolinite in coal appear to reduce its compressive strength at low confining stresses, resulting in easy failures of pillars and ribs in mine openings. Applications of the geologic factors outlined in this report, carefully coupled with advanced modern engineering methods, have markedly reduced the hazards from coal mine bumps and related failures of mine openings at Sunnyside. Similar studies probably could aid in reducing bump-related hazards in other coal mining areas.

Simulation studies of plasma waves in the electron foreshock - The generation of Langmuir waves by a gentle bump-on-tail electron distribution

NASA Technical Reports Server (NTRS)

Dum, C. T.

1990-01-01

Particle simulation experiments were used to study the basic physical ingredients needed for building a global model of foreshock wave phenomena. In particular, the generation of Langmuir waves by a gentle bump-on-tail electron distribution is analyzed. It is shown that, with appropriately designed simulations experiments, quasi-linear theory can be quantitatively verified for parameters corresponding to the electron foreshock.

Fabrication of Cantilever-Bump Type Si Probe Card

NASA Astrophysics Data System (ADS)

Park, Jeong-Yong; Lee, Dong-Seok; Kim, Dong-Kwon; Lee, Jong-Hyun

2000-12-01

Probe card is most important part in the test system which selects the good or bad chip of integrated circuit (IC) chips. Silicon vertical probe card is able to test multiple semiconductor chips simultaneously. We presented cantilever-bump type vertical probe card. It was fabricated by dry etching using RIE(reactive ion etching) technique and porous silicon micromachining using silicon direct bonded (SDB) wafer. Cantilevers and bumps were fabricated by isotropic etching using RIE@. 3-dimensional structures were formed by porous silicon micromachining technique using SDB wafer. Contact resistance of fabricated probe card was less than 2 Ω and its life time was more than 200,000 turns. The process used in this work is very simple and reproducible, which has good controllability in the tip dimension and spacing. It is expected that the fabricated probe card can reduce testing time, can promote productivity and enables burn-in test.

Neural field model of memory-guided search.

PubMed

Kilpatrick, Zachary P; Poll, Daniel B

2017-12-01

Many organisms can remember locations they have previously visited during a search. Visual search experiments have shown exploration is guided away from these locations, reducing redundancies in the search path before finding a hidden target. We develop and analyze a two-layer neural field model that encodes positional information during a search task. A position-encoding layer sustains a bump attractor corresponding to the searching agent's current location, and search is modeled by velocity input that propagates the bump. A memory layer sustains persistent activity bounded by a wave front, whose edges expand in response to excitatory input from the position layer. Search can then be biased in response to remembered locations, influencing velocity inputs to the position layer. Asymptotic techniques are used to reduce the dynamics of our model to a low-dimensional system of equations that track the bump position and front boundary. Performance is compared for different target-finding tasks.

Existence of multi-bump solutions for a class of Kirchhoff type problems in R{sup 3}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, Sihua, E-mail: liangsihua@126.com; College of Mathematics, Jilin University, Changchun 130012; Shi, Shaoyun, E-mail: shisy@mail.jlu.edu.cn

2013-12-15

Using variational methods, we establish existence of multi-bump solutions for a class of Kirchhoff type problems −(a+b∫{sub R{sup 3}}|∇u|{sup 2}dx)Δu+λV(x)u=f(u), where f is a continuous function with subcritical growth, V(x) is a critical frequency in the sense that inf{sub x∈R{sup 3}}V(x)=0. We show that if the zero set of V(x) has several isolated connected components Ω{sub 1}, …, Ω{sub k} such that the interior of Ω{sub i} is not empty and ∂Ω{sub i} is smooth, then for λ > 0 large there exists, for any non-empty subset J ⊂ (1, …, k), a bump solution is trapped in a neighborhoodmore » of ∪{sub j∈J}Ω{sub j}.« less

The first bump-bonded pixel detectors on CVD diamond

NASA Astrophysics Data System (ADS)

Adam, W.; Bauer, C.; Berdermann, E.; Bergonzo, P.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; van Eijk, B.; Fallou, A.; Fizzotti, F.; Foulon, F.; Friedl, M.; Gan, K. K.; Gheeraert, E.; Grigoriev, E.; Hallewell, G.; Hall-Wilton, R.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Karl, C.; Kass, R.; Krammer, M.; Logiudice, A.; Lu, R.; Manfredi, P. F.; Manfredotti, C.; Marshall, R. D.; Meier, D.; Mishina, M.; Oh, A.; Palmieri, V. G.; Pan, L. S.; Peitz, A.; Pernicka, M.; Pirollo, S.; Polesello, P.; Pretzl, K.; Re, V.; Riester, J. L.; Roe, S.; Roff, D.; Rudge, A.; Schnetzer, S.; Sciortino, S.; Speziali, V.; Stelzer, H.; Steuerer, J.; Stone, R.; Tapper, R. J.; Tesarek, R.; Trawick, M.; Trischuk, W.; Turchetta, R.; Vittone, E.; Wagner, A.; Walsh, A. M.; Wedenig, R.; Weilhammer, P.; Zeuner, W.; Ziock, H.; Zoeller, M.; Charles, E.; Ciocio, A.; Dao, K.; Einsweiler, K.; Fasching, D.; Gilchriese, M.; Joshi, A.; Kleinfelder, S.; Milgrome, O.; Palaio, N.; Richardson, J.; Sinervo, P.; Zizka, G.; RD42 Collaboration

1999-11-01

Diamond is a nearly ideal material for detecting ionising radiation. Its outstanding radiation hardness, fast charge collection and low leakage current allow it to be used in high radiation environments. These characteristics make diamond sensors particularly appealing for use in the next generation of pixel detectors. Over the last year, the RD42 collaboration has worked with several groups that have developed pixel readout electronics in order to optimise diamond sensors for bump-bonding. This effort resulted in an operational diamond pixel sensor that was tested in a pion beam. We demonstrate that greater than 98% of the channels were successfully bump-bonded and functioning. The device shows good overall hit efficiency as well as clear spatial hit correlation to tracks measured in a silicon reference telescope. A position resolution of 14.8 μm was observed, consistent with expectations given the detector pitch.

Neural field model of memory-guided search

NASA Astrophysics Data System (ADS)

Kilpatrick, Zachary P.; Poll, Daniel B.

2017-12-01

Many organisms can remember locations they have previously visited during a search. Visual search experiments have shown exploration is guided away from these locations, reducing redundancies in the search path before finding a hidden target. We develop and analyze a two-layer neural field model that encodes positional information during a search task. A position-encoding layer sustains a bump attractor corresponding to the searching agent's current location, and search is modeled by velocity input that propagates the bump. A memory layer sustains persistent activity bounded by a wave front, whose edges expand in response to excitatory input from the position layer. Search can then be biased in response to remembered locations, influencing velocity inputs to the position layer. Asymptotic techniques are used to reduce the dynamics of our model to a low-dimensional system of equations that track the bump position and front boundary. Performance is compared for different target-finding tasks.

Nanomechanical effects of light unveil photons momentum in medium

PubMed Central

Verma, Gopal; Chaudhary, Komal; Singh, Kamal P.

2017-01-01

Precision measurement on momentum transfer between light and fluid interface has many implications including resolving the intriguing nature of photons momentum in a medium. For example, the existence of Abraham pressure of light under specific experimental configuration and the predictions of Chau-Amperian formalism of optical momentum for TE and TM polarizations remain untested. Here, we quantitatively and cleanly measure nanomehanical dynamics of water surface excited by radiation pressure of a laser beam. We systematically scanned wide range of experimental parameters including long exposure times, angle of incidence, spot size and laser polarization, and used two independent pump-probe techniques to validate a nano- bump on the water surface under all the tested conditions, in quantitative agreement with the Minkowski’s momentum of light. With careful experiments, we demonstrate advantages and limitations of nanometer resolved optical probing techniques and narrow down actual manifestation of optical momentum in a medium. PMID:28198468

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanov, A.; Edstrom, D.; Emanov, F. A.

Precise beam based measurement and correction of magnetic optics is essential for the successful operation of accelerators. The LOCO algorithm is a proven and reliable tool, which in some situations can be improved by using a broader class of experimental data. The standard data sets for LOCO include the closed orbit responses to dipole corrector variation, dispersion, and betatron tunes. This paper discusses the benefits from augmenting the data with four additional classes of experimental data: the beam shape measured with beam profile monitors; responses of closed orbit bumps to focusing field variations; betatron tune responses to focusing field variations;more » BPM-to-BPM betatron phase advances and beta functions in BPMs from turn-by-turn coordinates of kicked beam. All of the described features were implemented in the Sixdsimulation software that was used to correct the optics of the VEPP-2000 collider, the VEPP-5 injector booster ring, and the FAST linac.« less

Silicon pixel-detector R&D for CLIC

NASA Astrophysics Data System (ADS)

Nürnberg, A.

2016-11-01

The physics aims at the future CLIC high-energy linear e+e- collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the time structure of the collisions and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few μm, ultra-low mass (~ 0.2%X0 per layer for the vertex region and ~ 1%X0 per layer for the outer tracker), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ~ 10 ns time stamping capabilities. A highly granular all-silicon vertex and tracking detector system is under development, following an integrated approach addressing simultaneously the physics requirements and engineering constraints. For the vertex-detector region, hybrid pixel detectors with small pitch (25 μm) and analog readout are explored. For the outer tracking region, both hybrid concepts and fully integrated CMOS sensors are under consideration. The feasibility of ultra-thin sensor layers is validated with Timepix3 readout ASICs bump bonded to active edge planar sensors with 50 μm to 150 μm thickness. Prototypes of CLICpix readout ASICs implemented in 6525 nm CMOS technology with 25 μm pixel pitch have been produced. Hybridisation concepts have been developed for interconnecting these chips either through capacitive coupling to active HV-CMOS sensors or through bump-bonding to planar sensors. Recent R&D achievements include results from beam tests with all types of hybrid assemblies. Simulations based on Geant4 and TCAD are used to validate the experimental results and to assess and optimise the performance of various detector designs.

Experiments to measure ablative Richtmyer-Meshkov growth of Gaussian bumps in plastic capsules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loomis, Eric; Batha, Steve; Sedillo, Tom

2010-06-02

Growth of hydrodynamic instabilities at the interfaces of inertial confinement fusion capsules (ICF) due to ablator and fuel non-uniformities have been of primary concern to the ICF program since its inception. To achieve thermonuclear ignition at Megajoule class laser systems such as the NIF, targets must be designed for high implosion velocities, which requires higher in-flight aspect ratios (IFAR) and diminished shell stability. Controlling capsule perturbations is thus of the utmost importance. Recent simulations have shown that features on the outer surface of an ICF capsule as small as 10 microns wide and 100's of nanometers tall such as bumps,more » divots, or even dust particles can profoundly impact capsule performance by leading to material jetting or mix into the hotspot. Recent x-ray images of implosions on the NIF may be evidence of such mixing. Unfortunately, our ability to accurately predict these effects is uncertain due to disagreement between equation of state (EOS) models. In light of this, we have begun a campaign to measure the growth of isolated defects (Gaussian bumps) due to ablative Richtmyer-Meshkov in CH capsules to validate these models. The platform that has been developed uses halfraums with radiation temperatures near 75 eV (Rev. 4 foot-level) driven by 15-20 beams from the Omega laser (Laboratory for Laser Energetics, University of Rochester, NY), which sends a ~2.5 Mbar shock into a planar CH foil. Gaussian-shaped bumps (20 microns wide, 4-7 microns tall) are deposited onto the ablation side of the target. On-axis radiography with a saran (Cl He α - 2.8 keV) backlighter is used to measure bump evolution prior to shock breakout. Shock speed measurements will also be made with Omega's active shock breakout (ASBO) and streaked optical pyrometery (SOP) diagnostics in conjunction with filtered x-ray photodiode arrays (DANTE) to determine drive conditions in the target. These data will be used to discriminate between EOS models so that one may be selected to design the shape and intensity of the foot in an ignition-level drive pulse so that bump amplitude is minimized by the time the shell begins to accelerate.« less

Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts.

PubMed

Hollands, Wendy J; Voorspoels, Stefan; Jacobs, Griet; Aaby, Kjersti; Meisland, Ane; Garcia-Villalba, Rocio; Tomas-Barberan, Francisco; Piskula, Mariusz K; Mawson, Deborah; Vovk, Irena; Needs, Paul W; Kroon, Paul A

2017-04-28

There is a lack of data for individual oligomeric procyanidins in apples and apple extracts. Our aim was to develop, validate and evaluate an analytical method for the separation, identification and quantification of monomeric and oligomeric flavanols in apple extracts. To achieve this, we prepared two types of flavanol extracts from freeze-dried apples; one was an epicatechin-rich extract containing ∼30% (w/w) monomeric (-)-epicatechin which also contained oligomeric procyanidins (Extract A), the second was an oligomeric procyanidin-rich extract depleted of epicatechin (Extract B). The parameters considered for method optimisation were HPLC columns and conditions, sample heating, mass of extract and dilution volumes. The performance characteristics considered for method validation included standard linearity, method sensitivity, precision and trueness. Eight laboratories participated in the method evaluation. Chromatographic separation of the analytes was best achieved utilizing a Hilic column with a binary mobile phase consisting of acidic acetonitrile and acidic aqueous methanol. The final method showed linearity for epicatechin in the range 5-100μg/mL with a correlation co-efficient >0.999. Intra-day and inter-day precision of the analytes ranged from 2 to 6% and 2 to 13% respectively. Up to dp3, trueness of the method was >95% but decreased with increasing dp. Within laboratory precision showed RSD values <5 and 10% for monomers and oligomers, respectively. Between laboratory precision was 4 and 15% (Extract A) and 7 and 30% (Extract B) for monomers and oligomers, respectively. An analytical method for the separation, identification and quantification of procyanidins in an apple extract was developed, validated and assessed. The results of the inter-laboratory evaluation indicate that the method is reliable and reproducible. Copyright © 2017. Published by Elsevier B.V.

Diagnostic Health Monitoring System Development for Army Vehicle Reliability

DTIC Science & Technology

2011-07-01

19-24 3.4 Receiver Operator Characteristics for fault detection ……………………….. 24-28 3.5 Extended diagnostic speed bump modal data analysis...extended diagnostic speed bump was akin to the use of modal impact testing for exciting broadband frequency ranges in mechanical systems for use in...for a front axle wheel crossing measured using long cleat for ( ) first 30, ( ) second 11, ( ) third 11, ( ) fourth 11, and ( ) fifth 11 data series

Local Sparse Bump Hunting

PubMed Central

Dazard, Jean-Eudes; Rao, J. Sunil

2010-01-01

The search for structures in real datasets e.g. in the form of bumps, components, classes or clusters is important as these often reveal underlying phenomena leading to scientific discoveries. One of these tasks, known as bump hunting, is to locate domains of a multidimensional input space where the target function assumes local maxima without pre-specifying their total number. A number of related methods already exist, yet are challenged in the context of high dimensional data. We introduce a novel supervised and multivariate bump hunting strategy for exploring modes or classes of a target function of many continuous variables. This addresses the issues of correlation, interpretability, and high-dimensionality (p ≫ n case), while making minimal assumptions. The method is based upon a divide and conquer strategy, combining a tree-based method, a dimension reduction technique, and the Patient Rule Induction Method (PRIM). Important to this task, we show how to estimate the PRIM meta-parameters. Using accuracy evaluation procedures such as cross-validation and ROC analysis, we show empirically how the method outperforms a naive PRIM as well as competitive non-parametric supervised and unsupervised methods in the problem of class discovery. The method has practical application especially in the case of noisy high-throughput data. It is applied to a class discovery problem in a colon cancer micro-array dataset aimed at identifying tumor subtypes in the metastatic stage. Supplemental Materials are available online. PMID:22399839

High Resolution N-Body Simulations of Terrestrial Planet Growth

NASA Astrophysics Data System (ADS)

Clark Wallace, Spencer; Quinn, Thomas R.

2018-04-01

We investigate planetesimal accretion with a direct N-body simulation of an annulus at 1 AU around a 1 M_sun star. The planetesimal ring, which initially contains N = 106 bodies is evolved through the runaway growth stage into the phase of oligarchic growth. We find that the mass distribution of planetesimals develops a bump around 1022 g shortly after the oligarchs form. This feature is absent in previous lower resolution studies. We find that this bump marks a boundary between growth modes. Below the bump mass, planetesimals are packed tightly enough together to populate first order mean motion resonances with the oligarchs. These resonances act to heat the tightly packed, low mass planetesimals, inhibiting their growth. We examine the eccentricity evolution of a dynamically hot planetary embryo embedded in an annulus of planetesimals and find that dynamical friction acts more strongly on the embryo when the planetesimals are finely resolved. This effect disappears when the annulus is made narrow enough to exclude most of the mean motion resonances. Additionally, we find that the 1022 g bump is significantly less prominent when we follow planetesimal growth with a skinny annulus.This feature, which is reminiscent of the power law break seen in the size distribution of asteroid belt objects may be an important clue for constraining the initial size of planetesimals in planet formation models.

Mean-time-to-failure study of flip chip solder joints on Cu/Ni(V)/Al thin-film under-bump-metallization

NASA Astrophysics Data System (ADS)

Choi, W. J.; Yeh, E. C. C.; Tu, K. N.

2003-11-01

Electromigration of eutectic SnPb flip chip solder joints and their mean-time-to-failure (MTTF) have been studied in the temperature range of 100 to 140 °C with current densities of 1.9 to 2.75×104 A/cm2. In these joints, the under-bump-metallization (UBM) on the chip side is a multilayer thin film of Al/Ni(V)/Cu, and the metallic bond-pad on the substrate side is a very thick, electroless Ni layer covered with 30 nm of Au. When stressed at the higher current densities, the MTTF was found to decrease much faster than what is expected from the published Black's equation. The failure occurred by interfacial void propagation at the cathode side, and it is due to current crowding near the contact interface between the solder bump and the thin-film UBM. The current crowding is confirmed by a simulation of current distribution in the solder joint. Besides the interfacial void formation, the intermetallic compounds formed on the UBM as well as the Ni(V) film in the UBM have been found to dissolve completely into the solder bump during electromigration. Therefore, the electromigation failure is a combination of the interfacial void formation and the loss of UBM. Similar findings in eutectic SnAgCu flip chip solder joints have also been obtained and compared.

Determination of the top quark mass circa 2013: methods, subtleties, perspectives

NASA Astrophysics Data System (ADS)

Juste, Aurelio; Mantry, Sonny; Mitov, Alexander; Penin, Alexander; Skands, Peter; Varnes, Erich; Vos, Marcel; Wimpenny, Stephen

2014-10-01

We present an up-to-date overview of the problem of top quark mass determination. We assess the need for precision in the top mass extraction in the LHC era together with the main theoretical and experimental issues arising in precision top mass determination. We collect and document existing results on top mass determination at hadron colliders and map the prospects for future precision top mass determination at e+e- colliders. We present a collection of estimates for the ultimate precision of various methods for top quark mass extraction at the LHC.

When the Desert Beetle Met the Carnivorous Plant: A Perfect Match for Droplet Growth and Shedding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aizenberg, Joanna; Park, Kyoo Chul; Kim, Philseok

2015-01-14

Phase change of vapor followed by coalescence and transport on ubiquitous bumped or curved surfaces is of fundamental importance for a wide range of phenomena and applications from water condensation on cold beverage bottles, to fogging on glasses and windshields, self-cleaning by jumping droplets, weathering, self-assembly, desalination, latent heat transfer, etc. Over the past decades, many attempts to understand and control the droplet growth dynamics and shedding of condensates on textured surfaces have focused on finding the role of micro/nanotexture combined with wettability. In particular, inspired by the Namib desert beetle bump structure, studies tested the effect of topography onmore » the preferential condensation. However, like the preferential condensation observed on flat surfaces, hybrid wettability rather than texture plays a major role; the role of bump topography on local preferential condensation has been unexplored and still not clearly understood. In addition, given that not only facilitating the droplet growth but also transporting the condensed droplets toward the desired reservoir is essential to make fresh sites for renucleation and regrowth of the droplets for enhancing condensation efficiency, the current hybrid-wettability- based design is not efficient to transport the condensates due to the high contact angle hysteresis created by highly wettable pinning points. Here we show that beetle-inspired bump topography leads faster localized condensation and transport of water. Employing simple analytic and more complicated numerical calculations, we reveal the detailed role of topography and predict the focused diffusion flux based on the distortion of concentration gradient around convex surface topography. We experimentally demonstrate the systematic understanding on the unseen effect of topographical parameters on faster droplet growth dynamics on various bump geometries. Further rational design of asymmetric topography and synergetic combination with slippery coating simultaneously enable both faster droplet growth and transport for applications including efficient water condensation.« less

[Extraction of buildings three-dimensional information from high-resolution satellite imagery based on Barista software].

PubMed

Zhang, Pei-feng; Hu, Yuan-man; He, Hong-shi

2010-05-01

The demand for accurate and up-to-date spatial information of urban buildings is becoming more and more important for urban planning, environmental protection, and other vocations. Today's commercial high-resolution satellite imagery offers the potential to extract the three-dimensional information of urban buildings. This paper extracted the three-dimensional information of urban buildings from QuickBird imagery, and validated the precision of the extraction based on Barista software. It was shown that the extraction of three-dimensional information of the buildings from high-resolution satellite imagery based on Barista software had the advantages of low professional level demand, powerful universality, simple operation, and high precision. One pixel level of point positioning and height determination accuracy could be achieved if the digital elevation model (DEM) and sensor orientation model had higher precision and the off-Nadir View Angle was relatively perfect.

Module comprising IC memory stack dedicated to and structurally combined with an IC microprocessor chip

NASA Technical Reports Server (NTRS)

Carson, John C. (Inventor); Indin, Ronald J. (Inventor); Shanken, Stuart N. (Inventor)

1994-01-01

A computer module is disclosed in which a stack of glued together IC memory chips is structurally integrated with a microprocessor chip. The memory provided by the stack is dedicated to the microprocessor chip. The microprocessor and its memory stack may be connected either by glue and/or by solder bumps. The solder bumps can perform three functions--electrical interconnection, mechanical connection, and heat transfer. The electrical connections in some versions are provided by wire bonding.

The neural speed of familiar face recognition.

PubMed

Barragan-Jason, G; Cauchoix, M; Barbeau, E J

2015-08-01

Rapidly recognizing familiar people from their faces appears critical for social interactions (e.g., to differentiate friend from foe). However, the actual speed at which the human brain can distinguish familiar from unknown faces still remains debated. In particular, it is not clear whether familiarity can be extracted from rapid face individualization or if it requires additional time consuming processing. We recorded scalp EEG activity in 28 subjects performing a go/no-go, famous/non-famous, unrepeated, face recognition task. Speed constraints were used to encourage subjects to use the earliest familiarity information available. Event related potential (ERP) analyses show that both the N170 and the N250 components were modulated by familiarity. The N170 modulation was related to behaviour: subjects presenting the strongest N170 modulation were also faster but less accurate than those who only showed weak N170 modulation. A complementary Multi-Variate Pattern Analysis (MVPA) confirmed ERP results and provided some more insights into the dynamics of face recognition as the N170 differential effect appeared to be related to a first transitory phase (transitory bump of decoding power) starting at around 140 ms, which returned to baseline afterwards. This bump of activity was henceforth followed by an increase of decoding power starting around 200 ms after stimulus onset. Overall, our results suggest that rather than a simple single-process, familiarity for faces may rely on a cascade of neural processes, including a coarse and fast stage starting at 140 ms and a more refined but slower stage occurring after 200 ms. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dynamics of feature categorization.

PubMed

Martí, Daniel; Rinzel, John

2013-01-01

In visual and auditory scenes, we are able to identify shared features among sensory objects and group them according to their similarity. This grouping is preattentive and fast and is thought of as an elementary form of categorization by which objects sharing similar features are clustered in some abstract perceptual space. It is unclear what neuronal mechanisms underlie this fast categorization. Here we propose a neuromechanistic model of fast feature categorization based on the framework of continuous attractor networks. The mechanism for category formation does not rely on learning and is based on biologically plausible assumptions, for example, the existence of populations of neurons tuned to feature values, feature-specific interactions, and subthreshold-evoked responses upon the presentation of single objects. When the network is presented with a sequence of stimuli characterized by some feature, the network sums the evoked responses and provides a running estimate of the distribution of features in the input stream. If the distribution of features is structured into different components or peaks (i.e., is multimodal), recurrent excitation amplifies the response of activated neurons, and categories are singled out as emerging localized patterns of elevated neuronal activity (bumps), centered at the centroid of each cluster. The emergence of bump states through sequential, subthreshold activation and the dependence on input statistics is a novel application of attractor networks. We show that the extraction and representation of multiple categories are facilitated by the rich attractor structure of the network, which can sustain multiple stable activity patterns for a robust range of connectivity parameters compatible with cortical physiology.

How can individual differences in autobiographical memory distributions of older adults be explained?

PubMed

Wolf, Tabea; Zimprich, Daniel

2016-10-01

The reminiscence bump phenomenon has frequently been reported for the recall of autobiographical memories. The present study complements previous research by examining individual differences in the distribution of word-cued autobiographical memories. More importantly, we introduce predictor variables that might account for individual differences in the mean (location) and the standard deviation (scale) of individual memory distributions. All variables were derived from different theoretical accounts for the reminiscence bump phenomenon. We used a mixed location-scale logitnormal model, to analyse the 4602 autobiographical memories reported by 118 older participants. Results show reliable individual differences in the location and the scale. After controlling for age and gender, individual proportions of first-time experiences and individual proportions of positive memories, as well as the ratings on Openness to new Experiences and Self-Concept Clarity accounted for 29% of individual differences in location and 42% of individual differences in scale of autobiographical memory distributions. Results dovetail with a life-story account for the reminiscence bump which integrates central components of previous accounts.

Running bumps from stealth bosons

NASA Astrophysics Data System (ADS)

Aguilar-Saavedra, J. A.

2018-03-01

For the `stealth bosons' S, light boosted particles with a decay S → A A → q \\bar{q} q \\bar{q} into four quarks and reconstructed as a single fat jet, the groomed jet mass has a strong correlation with groomed jet substructure variables. Consequently, the jet mass distribution is strongly affected by the jet substructure selection cuts when applied on the groomed jet. We illustrate this fact by recasting a CMS search for low-mass dijet resonances and show a few representative examples. The mass distributions exhibit narrow and wide bumps at several locations in the 100-300 GeV range, between the masses of the daughter particles A and the parent particle S, depending on the jet substructure selection. This striking observation introduces several caveats when interpreting and comparing experimental results, for the case of non-standard signatures. The possibility that a single boosted particle decaying hadronically produces multiple bumps, at quite different jet masses, and depending on the event selection, brings the anomaly chasing game to the next level.

Germanium ``hexa'' detector: production and testing

NASA Astrophysics Data System (ADS)

Sarajlić, M.; Pennicard, D.; Smoljanin, S.; Hirsemann, H.; Struth, B.; Fritzsch, T.; Rothermund, M.; Zuvic, M.; Lampert, M. O.; Askar, M.; Graafsma, H.

2017-01-01

Here we present new result on the testing of a Germanium sensor for X-ray radiation. The system is made of 3 × 2 Medipix3RX chips, bump-bonded to a monolithic sensor, and is called ``hexa''. Its dimensions are 45 × 30 mm2 and the sensor thickness was 1.5 mm. The total number of the pixels is 393216 in the matrix 768 × 512 with pixel pitch 55 μ m. Medipix3RX read-out chip provides photon counting read-out with single photon sensitivity. The sensor is cooled to -126°C and noise levels together with flat field response are measured. For -200 V polarization bias, leakage current was 4.4 mA (3.2 μ A/mm2). Due to higher leakage around 2.5% of all pixels stay non-responsive. More than 99% of all pixels are bump bonded correctly. In this paper we present the experimental set-up, threshold equalization procedure, image acquisition and the technique for bump bond quality estimate.

Biomimetic Water-Collecting Fabric with Light-Induced Superhydrophilic Bumps.

PubMed

Wang, Yuanfeng; Wang, Xiaowen; Lai, Chuilin; Hu, Huawen; Kong, Yeeyee; Fei, Bin; Xin, John H

2016-02-10

To develop an efficient water-collecting surface that integrates both fast water-capturing and easy drainage properties is of high current interest for addressing global water issues. In this work, a superhydrophobic surface was fabricated on cotton fabric via manipulation of both the surface roughness and surface energy. This was followed by a subsequent spray coating of TiO2 nanosol that created light-induced superhydrophilic bumps with a unique raised structure as a result of the interfacial tension of the TiO2 nanosol sprayed on the superhydrophobic fiber surface. These raised TiO2 bumps induce both a wettability gradient and a shape gradient, synergistically accelerating water coalescence and water collection. The in-depth study revealed that the quantity and the distribution of the TiO2 had a significant impact on the final water collection efficiency. This inexpensive and facilely fabricated fabric biomimicks the desert beetle's back and spider silk, which are capable of fog harvesting without additional energy consumption.

Cascading reminiscence bumps in popular music.

PubMed

Krumhansl, Carol Lynne; Zupnick, Justin Adam

2013-10-01

Autobiographical memories are disproportionately recalled for events in late adolescence and early adulthood, a phenomenon called the reminiscence bump. Previous studies on music have found autobiographical memories and life-long preferences for music from this period. In the present study, we probed young adults' personal memories associated with top hits over 5-and-a-half decades, as well as the context of their memories and their recognition of, preference for, quality judgments of, and emotional reactions to that music. All these measures showed the typical increase for music released during the two decades of their lives. Unexpectedly, we found that the same measures peaked for the music of participants' parents' generation. This finding points to the impact of music in childhood and suggests that these results reflect the prevalence of music in the home environment. An earlier peak occurred for 1960s music, which may be explained by its quality or by its transmission through two generations. We refer to this pattern of musical cultural transmission over generations as cascading reminiscence bumps.

Ultraviolet Imaging Telescope images of the reflection nebula NGC 7023 - Derivation of ultraviolet scattering properties of dust grains

NASA Technical Reports Server (NTRS)

Witt, Adolf N.; Petersohn, Jens K.; Bohlin, Ralph C.; O'Connell, Robert W.; Roberts, Morton S.; Smith, Andrew M.; Stecher, Theodore P.

1992-01-01

The Ultraviolet Imaging Telescope as part of the Astro-1 mission, was used to obtain high-resolution surface brightness distribution data in six ultraviolet wavelength bands for the bright reflection nebula NGC 7023. From the quantitative comparison of the measured surface brightness gradients ratios of nebular to stellar flux, and detail radial surface brightness profiles with corresponding data from the visible, two major conclusions results: (1) the scattering in the near- and far-ultraviolet in this nebula is more strongly forward-directed than in the visible; (2) the dust albedo in the ultraviolet for wavelengths not less than 140 nm is identical to that in the visible, with the exception of the 220 nm bump in the extinction curve. In the wavelengths region of the bump, the albedo is reduced by 25 to 30 percent in comparison with wavelengths regions both shorter and longer. This lower albedo is expected, if the bump is a pure absorption feature.

Infrared-Bolometer Arrays with Reflective Backshorts

NASA Technical Reports Server (NTRS)

Miller, Timothy M.; Abrahams, John; Allen, Christine A.

2011-01-01

Integrated circuits that incorporate square arrays of superconducting-transition- edge bolometers with optically reflective backshorts are being developed for use in image sensors in the spectral range from far infrared to millimeter wavelengths. To maximize the optical efficiency (and, thus, sensitivity) of such a sensor at a specific wavelength, resonant optical structures are created by placing the backshorts at a quarter wavelength behind the bolometer plane. The bolometer and backshort arrays are fabricated separately, then integrated to form a single unit denoted a backshort-under-grid (BUG) bolometer array. In a subsequent fabrication step, the BUG bolometer array is connected, by use of single-sided indium bump bonding, to a readout device that comprises mostly a superconducting quantum interference device (SQUID) multiplexer circuit. The resulting sensor unit comprising the BUG bolometer array and the readout device is operated at a temperature below 1 K. The concept of increasing optical efficiency by use of backshorts at a quarter wavelength behind the bolometers is not new. Instead, the novelty of the present development lies mainly in several features of the design of the BUG bolometer array and the fabrication sequence used to implement the design. Prior to joining with the backshort array, the bolometer array comprises, more specifically, a square grid of free-standing molybdenum/gold superconducting-transition-edge bolometer elements on a 1.4- m-thick top layer of silicon that is part of a silicon support frame made from a silicon-on-insulator wafer. The backshort array is fabricated separately as a frame structure that includes support beams and contains a correspond - ing grid of optically reflective patches on a single-crystal silicon substrate. The process used to fabricate the bolometer array includes standard patterning and etching steps that result in the formation of deep notches in the silicon support frame. These notches are designed to interlock with the support beams on the backshort-array structure to provide structural support and precise relative positioning. The backshort-array structure is inserted in the silicon support frame behind the bolometer array, and the notches in the frame serve to receive the support beams of the backshort-array structure and thus determine the distance between the backshort and bolometer planes. The depth of the notches and, thus, the distance between the backshort and bolometer planes, can be tailored to a value between 25 to 300 m adjusting only a few process steps. The backshort array is designed so as not to interfere with the placement of indium bumps for subsequent indium bump-bonding to the multiplexing readout circuitry

Local sparse bump hunting reveals molecular heterogeneity of colon tumors‡

PubMed Central

Dazard, Jean-Eudes; Rao, J. Sunil; Markowitz, Sanford

2013-01-01

The question of molecular heterogeneity and of tumoral phenotype in cancer remains unresolved. To understand the underlying molecular basis of this phenomenon, we analyzed genome-wide expression data of colon cancer metastasis samples, as these tumors are the most advanced and hence would be anticipated to be the most likely heterogeneous group of tumors, potentially exhibiting the maximum amount of genetic heterogeneity. Casting a statistical net around such a complex problem proves difficult because of the high dimensionality and multi-collinearity of the gene expression space, combined with the fact that genes act in concert with one another and that not all genes surveyed might be involved. We devise a strategy to identify distinct subgroups of samples and determine the genetic/molecular signature that defines them. This involves use of the local sparse bump hunting algorithm, which provides a much more optimal and biologically faithful transformed space within which to search for bumps. In addition, thanks to the variable selection feature of the algorithm, we derived a novel sparse gene expression signature, which appears to divide all colon cancer patients into two populations: a population whose expression pattern can be molecularly encompassed within the bump and an outlier population that cannot be. Although all patients within any given stage of the disease, including the metastatic group, appear clinically homogeneous, our procedure revealed two subgroups in each stage with distinct genetic/molecular profiles. We also discuss implications of such a finding in terms of early detection, diagnosis and prognosis. PMID:22052459

Enigmatic Extinction: An Investigation of the 2175Å Extinction Bump in M101

NASA Astrophysics Data System (ADS)

Danowski, Meredith E.; Cook, Timothy; Gordon, Karl D.; Chakrabarti, Supriya; Lawton, Brandon L.; Misselt, Karl A.

2014-06-01

Evidence from studies of starburst galaxies indicates that active formation of high mass stars modifies the UV dust extinction curve as seen by a lack of the characteristic 2175Å bump. For over 45 years, the source of the 2175Å extinction feature has yet to be positively identified. Small aromatic/PAH grains are suggested as a leading contender in dust grain models. The face-on spiral galaxy M101 is an ideal laboratory for the study of dust, with many well-studied HII regions and a steep metallicity and ionization gradient.The Interstellar Medium Absorption Gradient Experiment Rocket (IMAGER) probes the correlation between dust extinction, and the metallicity and radiation environment in M101 at ultraviolet wavelengths. IMAGER simultaneously images M101 in three 400Å-wide bandpasses, measuring the apparent strength of the 2175Å bump and the UV continuum.Combining data from IMAGER with high S/N far- and near- UV observations from the MAMA detectors on the Hubble STIS instrument, we examine the apparent strength of the 2175Å bump in HII regions of M101. With additional infrared data from Spitzer, the DIRTY radiative transfer model, and stellar evolution models, we probe the correlation between the 2175Å feature and the aromatic/PAH features across HII regions of varying metallicity and radiation field hardness. The results of this experiment will directly impact our understanding of the nature of dust and our ability to accurately account for the effects of dust on observations at all redshifts.

Modification of Bushing Test Rig and Research of Variable Inlet Guide Vane Bushings For Further Development of PM304 Bushings

NASA Technical Reports Server (NTRS)

Yanke, Anne

2004-01-01

PS304 is a high temperature solid lubricant coating comprised of a nickel-chrome binder, chrome oxide hardener, barium-calcium fluoride high temperature lubricant, and silver as the low temperature lubricant. This coating is used to lubricate Oil-Free Foil Air Bearings as they experience friction and wear during start up and shut down. The coating deposition process begins with undercutting the shaft. This area is then sandblasted to provide a rough surface for the coating to adhere to. The coating powder is then sent through the plasma spray gun and a reasonably thick layer is applied to the undercut area of the shaft. The coating is then ground down even with the surface of the shaft and gets a nice polished finish. The foil air bearings use the solid lubricant, as mentioned above, during start up and shut down. During normal operating conditions, generally above 2000RPM, the bearings utilize air as their lubricant. Foil air bearings are comprised of a thin top foil and a corrugated bump foil. They have an interference fit with the shaft before operation. As the air gets "trapped" between the top foil and the shaft, it presses the top foil against the bump foil, in turn compressing the bumps. As the bumps compress, it allows for the air to separate the top foil from the shaft, therefore, utilizing the trapped air as its lubricant.

What Do We Know About the Ultraviolet Extinction Curve, Fifty Years After the Discovery of the Bump?

NASA Astrophysics Data System (ADS)

Clayton, Geoffrey C.

2012-05-01

It is almost 50 years since Ted Stecher reported the discovery of the 2175 A bump, and almost 25 years since CCM characterized the UV extinction curve as a one-parameter function of R(V), the ratio of total-to-selective extinction. Great strides have been made since then in laboratory, theory, and observation but many questions still remain. The bump is still an unidentified feature, and CCM is not a reliable guide to the wavelength dependence of dust extinction beyond the Milky Way. In fact, the average extinction curve of SMC dust, which has little or no evidence for a 2175 A bump, may be more common in extragalactic environments than Milky Way type dust. The UV extinction curve has been extended to the Lyman limit without any sign in a turnover in the far-UV rise. The old standbys, silicates, graphite, amorphous carbon, and PAH's are still the go-to grain types. But many questions remain about how global properties such as metallicity may lead to large variations in the extinction properties from one galaxy to another. Also of great interest is how dust grains are created, evolve and are destroyed, and in particular, what fraction comes from sources such as evolved stars and supernovae, and what fraction is grown in the ISM. I plan to summarize the role of laboratory and theory can play in better understanding the interstellar dust grains responsible UV extinction.

Subsonic structure and optically thick winds from Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Grassitelli, L.; Langer, N.; Grin, N. J.; Mackey, J.; Bestenlehner, J. M.; Gräfener, G.

2018-06-01

Mass loss by stellar wind is a key agent in the evolution and spectroscopic appearance of massive main sequence and post-main sequence stars. In Wolf-Rayet stars the winds can be so dense and so optically thick that the photosphere appears in the highly supersonic part of the outflow, veiling the underlying subsonic part of the star, and leaving the initial acceleration of the wind inaccessible to observations. Here we investigate the conditions and the structure of the subsonic part of the outflow of Galactic Wolf-Rayet stars, in particular of the WNE subclass; our focus is on the conditions at the sonic point of their winds. We compute 1D hydrodynamic stellar structure models for massive helium stars adopting outer boundaries at the sonic point. We find that the outflows of our models are accelerated to supersonic velocities by the radiative force from opacity bumps either at temperatures of the order of 200 kK by the iron opacity bump or of the order of 50 kK by the helium-II opacity bump. For a given mass-loss rate, the diffusion approximation for radiative energy transport allows us to define the temperature gradient based purely on the local thermodynamic conditions. For a given mass-loss rate, this implies that the conditions in the subsonic part of the outflow are independent from the detailed physical conditions in the supersonic part. Stellar atmosphere calculations can therefore adopt our hydrodynamic models as ab initio input for the subsonic structure. The close proximity to the Eddington limit at the sonic point allows us to construct a sonic HR diagram, relating the sonic point temperature to the luminosity-to-mass ratio and the stellar mass-loss rate, thereby constraining the sonic point conditions, the subsonic structure, and the stellar wind mass-loss rates of WNE stars from observations. The minimum stellar wind mass-loss rate necessary to have the flow accelerated to supersonic velocities by the iron opacity bump is derived. A comparison of the observed parameters of Galactic WNE stars to this minimum mass-loss rate indicates that these stars have their winds launched to supersonic velocities by the radiation pressure arising from the iron opacity bump. Conversely, stellar models which do not show transonic flows from the iron opacity bump form low-density extended envelopes. We derive an analytic criterion for the appearance of envelope inflation and of a density inversion in the outer sub-photospheric layers.

Precision spectroscopy of the 2S-4P transition in atomic hydrogen

NASA Astrophysics Data System (ADS)

Maisenbacher, Lothar; Beyer, Axel; Matveev, Arthur; Grinin, Alexey; Pohl, Randolf; Khabarova, Ksenia; Kolachevsky, Nikolai; Hänsch, Theodor W.; Udem, Thomas

2017-04-01

Precision measurements of atomic hydrogen have long been successfully used to extract fundamental constants and to test bound-state QED. However, both these applications are limited by measurements of hydrogen lines other than the very precisely known 1S-2S transition. Moreover, the proton r.m.s.charge radius rp extracted from electronic hydrogen measurements currently disagrees by 4 σ with the much more precise value extracted from muonic hydrogen spectroscopy. We have measured the 2S-4P transition in atomic hydrogen using a cryogenic beam of hydrogen atoms optically excited to the initial 2S state. The first order Doppler shift of the one-photon 2S-4P transition is suppressed by actively stabilized counter-propagating laser beams and time-of-flight resolved detection. Quantum interference between excitation paths can lead to significant line distortions in our system. We use an experimentally verified, simple line shape model to take these distortions into account. With this, we can extract a new value for rp and the Rydberg constant R∞ with comparable accuracy as the combined previous H world data.

Experimental Studies on the Effects of Thermal Bumps in the Flow-Field around a Flat Plate using a Hypersonic Wind Tunnel

DTIC Science & Technology

2012-07-01

Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) 12 July 2012 2. REPORT TYPE Final Report 3. DATES COVERED...From – To) 1 October 2008 – 31 January 2012 4. TITLE AND SUBTITLE Experimental Studies on the Effects of Thermal Bumps in the Flow-Field around a

On the Existence of Positive Solutions of Semilinear Elliptic Equations.

DTIC Science & Technology

1981-04-01

vt I (0 < p < q < r,0< c <’<) I / -30- OIL - 111.2. Bumps and the shape of the nonlinearity: We want, in this section, to show how bumps or some...8l P L LONS DAAG29-80-C-0041 UNCLASSI RC-TSR-2209wL Eh|IEIIEEEEEEE EElhlEEEEEEEEE I IEEEEIIEEEII ARC echncajSummary Repprt # 2209 QON THE EXISTENCE OF...35P30 Key Words: Semilinear equations, positive solutions, topological degree, bifurcation Work Unit Number I - Applied Analysis *Laboratoire

Short medial approach harvesting of hamstring tendons.

PubMed

Lanternier, H; de Cussac, J B; Collet, T

2016-04-01

Harvesting the hamstring tendons for anterior cruciate ligament reconstruction is not straightforward to perform or to teach: the incision is small, the work-space is narrow and the surgeon's tactile feedback using the stripper is difficult to explain to juniors. The purpose of this short note is to describe a reliable means of harvesting the semitendinosus, gracilis or both. Patient and tourniquet positioning, instrumentation and landmarks are detailed; then the 6 steps (speed-bump 1, speed-bump 2, bubble, hook, expansions, stripper) are explained. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Search For ɛ-Bound Nuclei

NASA Astrophysics Data System (ADS)

Machner, H.

2011-10-01

The η meson can be bound to atomic nuclei. Experimental search is discussed in the form of final state interaction for the reactions dp→3Heη and dd→4Heη. For the latter case tensor polarized deuterons were used in order to extract the s-wave strength. For both reactions complex scattering lengths are deduced: In a two-nucleon transfer reaction under quasi-free conditions, p27Al→3HeX, was investigated. The system X can be the bound 25Mg⊗η at rest. When a possible decay of an intermediate N*(1535) is required, a highly significant bump shows up in the missing mass spectrum. The data give for a bound state a binding energy of 13.3±1.6 MeV and a width of σ = 4.4±1.3 MeV.

Stochastic, adaptive sampling of information by microvilli in fly photoreceptors.

PubMed

Song, Zhuoyi; Postma, Marten; Billings, Stephen A; Coca, Daniel; Hardie, Roger C; Juusola, Mikko

2012-08-07

In fly photoreceptors, light is focused onto a photosensitive waveguide, the rhabdomere, consisting of tens of thousands of microvilli. Each microvillus is capable of generating elementary responses, quantum bumps, in response to single photons using a stochastically operating phototransduction cascade. Whereas much is known about the cascade reactions, less is known about how the concerted action of the microvilli population encodes light changes into neural information and how the ultrastructure and biochemical machinery of photoreceptors of flies and other insects evolved in relation to the information sampling and processing they perform. We generated biophysically realistic fly photoreceptor models, which accurately simulate the encoding of visual information. By comparing stochastic simulations with single cell recordings from Drosophila photoreceptors, we show how adaptive sampling by 30,000 microvilli captures the temporal structure of natural contrast changes. Following each bump, individual microvilli are rendered briefly (~100-200 ms) refractory, thereby reducing quantum efficiency with increasing intensity. The refractory period opposes saturation, dynamically and stochastically adjusting availability of microvilli (bump production rate: sample rate), whereas intracellular calcium and voltage adapt bump amplitude and waveform (sample size). These adapting sampling principles result in robust encoding of natural light changes, which both approximates perceptual contrast constancy and enhances novel events under different light conditions, and predict information processing across a range of species with different visual ecologies. These results clarify why fly photoreceptors are structured the way they are and function as they do, linking sensory information to sensory evolution and revealing benefits of stochasticity for neural information processing. Copyright © 2012 Elsevier Ltd. All rights reserved.

Descemet Stripping Automated Endothelial Keratoplasty for Failed Penetrating Keratoplasty: Influence of the Graft-Host Junction on the Graft Survival Rate.

PubMed

Omoto, Takashi; Sakisaka, Toshihiro; Toyono, Tetsuya; Yoshida, Junko; Shirakawa, Rika; Miyai, Takashi; Yamagami, Satoru; Usui, Tomohiko

2018-04-01

To investigate the clinical results of Descemet stripping automated endothelial keratoplasty (DSAEK) for failed penetrating keratoplasty (PK) and the influence of the graft-host junction (GHJ) on the graft survival rate. Data were retrospectively collected on patient demographics, visual outcomes, complications, and graft survival rate for 17 eyes of 16 patients who underwent DSAEK for failed PK. The graft survival rate was compared between the eyes when divided into a bump group and a well-aligned group according to the shape of the GHJ detected on anterior segment optical coherence tomography. The most common indication for initial PK was bullous keratopathy after glaucoma surgery (35.3%). Seven eyes (41.2%) were classified into the bump group and 10 eyes (58.8%) into the well-aligned group. The mean best-ever documented visual acuity (BDVA) after DSAEK was 0.33 logMAR. Postoperatively, almost 70% of eyes achieved a BDVA that was within 0.2 logMAR of their preoperative BDVA. Graft detachment occurred in 29.4% of eyes and primary graft failure in 17.6%. All primary failures occurred in the bump group. The cumulative graft survival rate was 82.3% at 1 year, 73.2% at 2 years, and 58.6% at 3 years. Graft failure was more likely in eyes in the bump group than in those in the well-aligned group (P = 0.037, Wilcoxon test). DSAEK for failed PK had a favorable outcome in this study. However, the GHJ should be assessed carefully before performing the procedure.

Patterned Polymer Coatings Increase the Efficiency of Dew Harvesting.

PubMed

Al-Khayat, Omar; Hong, Jun Ki; Beck, David M; Minett, Andrew I; Neto, Chiara

2017-04-19

Micropatterned polymer surfaces, possessing both topographical and chemical characteristics, were prepared on three-dimensional copper tubes and used to capture atmospheric water. The micropatterns mimic the structure on the back of a desert beetle that condenses water from the air in a very dry environment. The patterned coatings were prepared by the dewetting of thin films of poly-4-vinylpyridine (P4VP) on top of polystyrene films (PS) films, upon solvent annealing, and consist of raised hydrophilic bumps on a hydrophobic background. The size and density distribution of the hydrophilic bumps could be tuned widely by adjusting the initial thickness of the P4VP films: the diameter of the produced bumps and their height could be varied by almost 2 orders of magnitude (1-80 μm and 40-9000 nm, respectively), and their distribution density could be varied by 5 orders of magnitude. Under low subcooling conditions (3 °C), the highest rate of water condensation was measured on the largest (80 μm diameter) hydrophilic bumps and was found to be 57% higher than that on flat hydrophobic films. These subcooling conditions are achieved spontaneously in dew formation, by passive radiative cooling of a surface exposed to the night sky. In effect, the pattern would result in a larger number of dewy nights than a flat hydrophobic surface and therefore increases water capture efficiency. Our approach is suited to fabrication on a large scale, to enable the use of the patterned coatings for water collection with no external input of energy.

Stochastic, Adaptive Sampling of Information by Microvilli in Fly Photoreceptors

PubMed Central

Song, Zhuoyi; Postma, Marten; Billings, Stephen A.; Coca, Daniel; Hardie, Roger C.; Juusola, Mikko

2012-01-01

Summary Background In fly photoreceptors, light is focused onto a photosensitive waveguide, the rhabdomere, consisting of tens of thousands of microvilli. Each microvillus is capable of generating elementary responses, quantum bumps, in response to single photons using a stochastically operating phototransduction cascade. Whereas much is known about the cascade reactions, less is known about how the concerted action of the microvilli population encodes light changes into neural information and how the ultrastructure and biochemical machinery of photoreceptors of flies and other insects evolved in relation to the information sampling and processing they perform. Results We generated biophysically realistic fly photoreceptor models, which accurately simulate the encoding of visual information. By comparing stochastic simulations with single cell recordings from Drosophila photoreceptors, we show how adaptive sampling by 30,000 microvilli captures the temporal structure of natural contrast changes. Following each bump, individual microvilli are rendered briefly (∼100–200 ms) refractory, thereby reducing quantum efficiency with increasing intensity. The refractory period opposes saturation, dynamically and stochastically adjusting availability of microvilli (bump production rate: sample rate), whereas intracellular calcium and voltage adapt bump amplitude and waveform (sample size). These adapting sampling principles result in robust encoding of natural light changes, which both approximates perceptual contrast constancy and enhances novel events under different light conditions, and predict information processing across a range of species with different visual ecologies. Conclusions These results clarify why fly photoreceptors are structured the way they are and function as they do, linking sensory information to sensory evolution and revealing benefits of stochasticity for neural information processing. PMID:22704990

Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors

PubMed Central

Chu, Brian; Liu, Che-Hsiung; Sengupta, Sukanya; Gupta, Amit; Raghu, Padinjat

2013-01-01

Absolute visual thresholds are limited by “dark noise,” which in Drosophila photoreceptors is dominated by brief (∼10 ms), small (∼2 pA) inward current events, occurring at ∼2/s, believed to reflect spontaneous G protein activations. These dark events were increased in rate and amplitude by a point mutation in myosin III (NINAC), which disrupts its interaction with the scaffolding protein, INAD. This phenotype mimics that previously described in null mutants of ninaC (no inactivation no afterpotential; encoding myosin III) and an associated protein, retinophilin (rtp). Dark noise was similarly increased in heterozygote mutants of diacylglycerol kinase (rdgA/+). Dark noise in ninaC, rtp, and rdgA/+ mutants was greatly suppressed by mutations of the Gq α-subunit (Gαq) and the major light-sensitive channel (trp) but not rhodopsin. ninaC, rtp, and rdgA/+ mutations also all facilitated residual light responses in Gαq and PLC hypomorphs. Raising cytosolic Ca2+ in the submicromolar range increased dark noise, facilitated activation of transient receptor potential (TRP) channels by exogenous agonist, and again facilitated light responses in Gαq hypomorphs. Our results indicate that RTP, NINAC, INAD, and diacylglycerol kinase, together with a Ca2+-dependent threshold, share common roles in suppressing dark noise and regulating quantum bump generation; consequently, most spontaneous G protein activations fail to generate dark events under normal conditions. By contrast, quantum bump generation is reliable but delayed until sufficient G proteins and PLC are activated to overcome threshold, thereby ensuring generation of full-size bumps with high quantum efficiency. PMID:23365183

Self-sustained oscillations with acoustic feedback in flows over a backward-facing step with a small upstream step

NASA Astrophysics Data System (ADS)

Yokoyama, Hiroshi; Tsukamoto, Yuichi; Kato, Chisachi; Iida, Akiyoshi

2007-10-01

Self-sustained oscillations with acoustic feedback take place in a flow over a two-dimensional two-step configuration: a small forward-backward facing step, which we hereafter call a bump, and a relatively large backward-facing step (backstep). These oscillations can radiate intense tonal sound and fatigue nearby components of industrial products. We clarify the mechanism of these oscillations by directly solving the compressible Navier-Stokes equations. The results show that vortices are shed from the leading edge of the bump and acoustic waves are radiated when these vortices pass the trailing edge of the backstep. The radiated compression waves shed new vortices by stretching the vortex formed by the flow separation at the leading edge of the bump, thereby forming a feedback loop. We propose a formula based on a detailed investigation of the phase relationship between the vortices and the acoustic waves for predicting the frequencies of the tonal sound. The frequencies predicted by this formula are in good agreement with those measured in the experiments we performed.

Dropwise condensation on hydrophobic bumps and dimples

NASA Astrophysics Data System (ADS)

Yao, Yuehan; Aizenberg, Joanna; Park, Kyoo-Chul

2018-04-01

Surface topography plays an important role in promoting or suppressing localized condensation. In this work, we study the growth of water droplets on hydrophobic convex surface textures such as bumps and concave surface textures such as dimples with a millimeter scale radius of curvature. We analyze the spatio-temporal droplet size distribution under a supersaturation condition created by keeping the uniform surface temperature below the dew point and show its relationship with the sign and magnitude of the surface curvature. In particular, in contrast to the well-known capillary condensation effect, we report an unexpectedly less favorable condensation on smaller, millimeter-scale dimples where the capillary condensation effect is negligible. To explain these experimental results, we numerically calculated the diffusion flux of water vapor around the surface textures, showing that its magnitude is higher on bumps and lower on dimples compared to a flat surface. We envision that our understanding of millimetric surface topography can be applied to improve the energy efficiency of condensation in applications such as water harvesting, heating, ventilation, and air conditioning systems for buildings and transportation, heat exchangers, thermal desalination plants, and fuel processing systems.

R package PRIMsrc: Bump Hunting by Patient Rule Induction Method for Survival, Regression and Classification

PubMed Central

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

2015-01-01

PRIMsrc is a novel implementation of a non-parametric bump hunting procedure, based on the Patient Rule Induction Method (PRIM), offering a unified treatment of outcome variables, including censored time-to-event (Survival), continuous (Regression) and discrete (Classification) responses. To fit the model, it uses a recursive peeling procedure with specific peeling criteria and stopping rules depending on the response. To validate the model, it provides an objective function based on prediction-error or other specific statistic, as well as two alternative cross-validation techniques, adapted to the task of decision-rule making and estimation in the three types of settings. PRIMsrc comes as an open source R package, including at this point: (i) a main function for fitting a Survival Bump Hunting model with various options allowing cross-validated model selection to control model size (#covariates) and model complexity (#peeling steps) and generation of cross-validated end-point estimates; (ii) parallel computing; (iii) various S3-generic and specific plotting functions for data visualization, diagnostic, prediction, summary and display of results. It is available on CRAN and GitHub. PMID:26798326

Experimental study of the energy dependence of the total cross section for the 6He + natSi and 9Li + natSi reactions

NASA Astrophysics Data System (ADS)

Sobolev, Yu. G.; Penionzhkevich, Yu. E.; Aznabaev, D.; Zemlyanaya, E. V.; Ivanov, M. P.; Kabdrakhimova, G. D.; Kabyshev, A. M.; Knyazev, A. G.; Kugler, A.; Lashmanov, N. A.; Lukyanov, K. V.; Maj, A.; Maslov, V. A.; Mendibayev, K.; Skobelev, N. K.; Slepnev, R. S.; Smirnov, V. V.; Testov, D.

2017-11-01

New experimental measurements of the total reaction cross sections for the 6He + natSi and 9Li + natSi processes in the energy range of 5 to 40 A MeV are presented. A modified transmission method based on high-efficiency detection of prompt n-γ radiation has been used in the experiment. A bump is observed for the first time in the energy dependence σR( E) at E ˜ 10-30 A MeV for the 9Li + natSi reaction, and existence of the bump in σR( E) at E ˜ 10-20 A MeV first observed in the standard transmission experiments is experimentally confirmed for the 6He + natSi reaction. Theoretical analysis of the measured 6He + natSi and 9Li + natSi reaction cross sections is performed within the microscopic double folding model. Disagreement is observed between the experimental and theoretical cross sections in the region of the bump at the energies of 10 to 20 A MeV, which requires further study.

First demonstration of the fast-to-slow corrector current shift in the NSLS-II storage ring

NASA Astrophysics Data System (ADS)

Yang, Xi; Tian, Yuke; Yu, Li Hua; Smaluk, Victor

2018-04-01

To realize the full benefits of the high brightness and ultra-small beam sizes of NSLS-II, it is essential that the photon beams are exceedingly stable. In the circumstances of implementing local bumps, changing ID gaps, and long term drifting, the fast orbit feedback (FOFB) requires shifting the fast corrector strengths to the slow correctors to prevent the fast corrector saturation and to make the beam orbit stable in the sub-micron level. As the result, a reliable and precise technique of fast-to-slow corrector strength shift has been developed and tested at NSLS-II. This technique is based on the fast corrector response to the slow corrector change when the FOFB is on. In this article, the shift technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented. The maximum fast corrector current was reduced from greater than 0.45 A to less than 0.04 A with the orbit perturbation within ±1 μm.

Formation of halloysite from feldspar: Low temperature, artificial weathering versus natural weathering

USGS Publications Warehouse

Parham, Walter E.

1969-01-01

Weathering products formed on surfaces of both potassium and plagioclase feldspar (An70), which were continuously leached in a Soxhlet extraction apparatus for 140 days with 7.21 of distilled water per day at a temperature of approximately 78°C, are morphologically identical to natural products developed on potassium feldspars weathered under conditions of good drainage in the humid tropics. The new products, which first appear as tiny bumps on the feldspar surface, start to develop mainly at exposed edges but also at apparently random sites on flat cleavage surfaces. As weathering continues, the bumps grow outward from the feldspar surface to form tapered projections, which then develop into wide-based thin films or sheets. The thin sheets of many projections merge laterally to form one continuous flame-shaped sheet. The sheets formed on potassium feldspars may then roll to form tubes that are inclined at a high angle to the feldspar surface. Etch pits of triangular outline on the artificially weathered potassium feldspars serve as sites for development of continuous, non-rolled, hollow tubes. It is inferred from its morphology that this weathering product is halloysite or its primitive form. The product of naturally weathered potassium feldspars is halloysite . 4H2O.The flame-shaped films or sheets formed on artificially weathered plagioclase feldspar do not develop into hollow tubes, but instead give rise to a platy mineral that is most probably boehmite. These plates form within the flame-shaped films, and with continued weathering are released as the film deteriorates. There is no indication from this experiment that platy pseudohexagonal kaolinite forms from any of these minerals under the initial stage of weathering.

Semiautomated solid-phase extraction manifold with a solvent-level sensor.

PubMed

Orlando, R M; Rath, S; Rohwedder, J J R

2013-11-15

A semiautomated solid-phase extraction manifold for multiple extractions is presented. The manifold utilizes commercial solid-phase syringe cartridges and automatically introduces and elutes all the solvents during the extraction, reducing the typical workload and stress of the analyst. The manifold consists of a peristaltic pump with solenoid valves in a flow circuit that contains transmissive photomicrosensors. The photomicrosensors were used to control the solvent dispenser and the solvent level inside the cartridge. As solvent-level sensors, the photomicrosensors determined the exact time the solvent reached the top frit to avoid sorbent drying and accurately perform the solvent exchange. The repeatability of the manifold to introduce a particular volume of solvent into the cartridges was measured, and the precisions were between 0.05 and 2.89% (RSD). To evaluate the manifold, the amount of two fluoroquinolones in a fortified blank milk sample was determined. The results of the intra- and inter-day precision of multiple extractions from the fortified milk samples resulted in precisions better than 9.0% (RSD) and confirmed that the arrangement of the semiautomated manifold could adequately be used in solid-phase extraction with commercial cartridges. Copyright © 2013 Elsevier B.V. All rights reserved.

Numerical studies of nonspherical carbon combustion models

NASA Astrophysics Data System (ADS)

Mueller, E.; Arnett, W. D.

1982-10-01

First results of axisymmetric numerical studies of the final evolution of degenerate C + O cores are reported. The two-dimensional convective flow is treated without a phenomenological theory of convection. The computations show that, in the beginning, the nuclear burning propagates slowly outward from the center of the star in a spherical combustion front. Small-scale eddies form, giving rise to bumps in the front. The bumps grow into blobs and eventually into fingers, which steadily elongate relative to the rest of the combustion front. This behavior is not well described by either the detonation or deflagration models, being more complex than either.

Interpretation of OAO-2 ultraviolet light curves of beta Doradus

NASA Technical Reports Server (NTRS)

Hutchinson, J. L.; Lillie, C. F.; Hill, S. J.

1975-01-01

Middle-ultraviolet light curves of beta Doradus, obtained by OAO-2, are presented along with other evidence indicating that the small additional bumps observed on the rising branches of these curves have their origin in shock-wave phenomena in the upper atmosphere of this classical Cepheid. A simple piston-driven spherical hydrodynamic model of the atmosphere is developed to explain the bumps, and the calculations are compared with observations. The model is found to be consistent with the shapes of the light curves as well as with measurements of the H-alpha radial velocities.

Topographic coupling of surface and internal Kelvin waves. [of ocean

NASA Technical Reports Server (NTRS)

Chao, S.-Y.

1980-01-01

An analysis is presented for computing the diffraction of barotropic Kelvin waves by a localized topographical irregularity on flat-bottom ocean with an arbitrary vertical stratification. It was shown that all baroclinic Kelvin waves will be generated downstream of the bump, with the first baroclinic mode having the largest amplitude. The Poincare waves predominate in the lowest modes, and are more directionally anisotropic. It was concluded that baroclinic Poincare waves radiating offshore from the bump topography could contribute to the internal wave field in the open ocean and provide an alternative mechanism to dissipate the barotropic tides.

Flexure Bearing Reduces Startup Friction

NASA Technical Reports Server (NTRS)

Clingman, W. Dean

1991-01-01

Design concept for ball bearing incorporates small pieces of shim stock, wire spokes like those in bicycle wheels, or other flexing elements to reduce both stiction and friction slope. In flexure bearing, flexing elements placed between outer race of ball bearing and outer ring. Elements flex when ball bearings encounter small frictional-torque "bumps" or even larger ones when bearing balls encounter buildups of grease on inner or outer race. Flexure of elements reduce high friction slopes of "bumps", helping to keep torque between outer ring and inner race low and more nearly constant. Concept intended for bearings in gimbals on laser and/or antenna mirrors.

Gamma ray astronomy and black hole astrophysics

NASA Technical Reports Server (NTRS)

Liang, Edison P.

1990-01-01

The study of soft gamma emissions from black-hole candidates is identified as an important element in understanding black-hole phenomena ranging from stellar-mass black holes to AGNs. The spectra of Cyg X-1 and observations of the Galactic Center are emphasized, since thermal origins and MeV gamma-ray bumps are evident and suggest a thermal-pair cloud picture. MeV gamma-ray observations are suggested for studying black hole astrophysics such as the theorized escaping pair wind, the anticorrelation between the MeV gamma bump and the soft continuum, and the relationship between source compactness and temperature.

Decoding Mode-mixing in Black-hole Merger Ringdown

NASA Technical Reports Server (NTRS)

Kelly, Bernard J.; Baker, John G.

2013-01-01

Optimal extraction of information from gravitational-wave observations of binary black-hole coalescences requires detailed knowledge of the waveforms. Current approaches for representing waveform information are based on spin-weighted spherical harmonic decomposition. Higher-order harmonic modes carrying a few percent of the total power output near merger can supply information critical to determining intrinsic and extrinsic parameters of the binary. One obstacle to constructing a full multi-mode template of merger waveforms is the apparently complicated behavior of some of these modes; instead of settling down to a simple quasinormal frequency with decaying amplitude, some |m| = modes show periodic bumps characteristic of mode-mixing. We analyze the strongest of these modes the anomalous (3, 2) harmonic mode measured in a set of binary black-hole merger waveform simulations, and show that to leading order, they are due to a mismatch between the spherical harmonic basis used for extraction in 3D numerical relativity simulations, and the spheroidal harmonics adapted to the perturbation theory of Kerr black holes. Other causes of mode-mixing arising from gauge ambiguities and physical properties of the quasinormal ringdown modes are also considered and found to be small for the waveforms studied here.

Extracting Date/Time Expressions in Super-Function Based Japanese-English Machine Translation

NASA Astrophysics Data System (ADS)

Sasayama, Manabu; Kuroiwa, Shingo; Ren, Fuji

Super-Function Based Machine Translation(SFBMT) which is a type of Example-Based Machine Translation has a feature which makes it possible to expand the coverage of examples by changing nouns into variables, however, there were problems extracting entire date/time expressions containing parts-of-speech other than nouns, because only nouns/numbers were changed into variables. We describe a method for extracting date/time expressions for SFBMT. SFBMT uses noun determination rules to extract nouns and a bilingual dictionary to obtain correspondence of the extracted nouns between the source and the target languages. In this method, we add a rule to extract date/time expressions and then extract date/time expressions from a Japanese-English bilingual corpus. The evaluation results shows that the precision of this method for Japanese sentences is 96.7%, with a recall of 98.2% and the precision for English sentences is 94.7%, with a recall of 92.7%.

Lensing corrections to features in the angular two-point correlation function and power spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

LoVerde, Marilena; Department of Physics, Columbia University, New York, New York 10027; Hui, Lam

2008-01-15

It is well known that magnification bias, the modulation of galaxy or quasar source counts by gravitational lensing, can change the observed angular correlation function. We investigate magnification-induced changes to the shape of the observed correlation function w({theta}), and the angular power spectrum C{sub l}, paying special attention to the matter-radiation equality peak and the baryon wiggles. Lensing effectively mixes the correlation function of the source galaxies with that of the matter correlation at the lower redshifts of the lenses distorting the observed correlation function. We quantify how the lensing corrections depend on the width of the selection function, themore » galaxy bias b, and the number count slope s. The lensing correction increases with redshift and larger corrections are present for sources with steep number count slopes and/or broad redshift distributions. The most drastic changes to C{sub l} occur for measurements at high redshifts (z > or approx. 1.5) and low multipole moment (l < or approx. 100). For the source distributions we consider, magnification bias can shift the location of the matter-radiation equality scale by 1%-6% at z{approx}1.5 and by z{approx}3.5 the shift can be as large as 30%. The baryon bump in {theta}{sup 2}w({theta}) is shifted by < or approx. 1% and the width is typically increased by {approx}10%. Shifts of > or approx. 0.5% and broadening > or approx. 20% occur only for very broad selection functions and/or galaxies with (5s-2)/b > or approx. 2. However, near the baryon bump the magnification correction is not constant but is a gently varying function which depends on the source population. Depending on how the w({theta}) data is fitted, this correction may need to be accounted for when using the baryon acoustic scale for precision cosmology.« less

Results from the NA62 Gigatracker Prototype: A Low-Mass and sub-ns Time Resolution Silicon Pixel Detector

NASA Astrophysics Data System (ADS)

Fiorini, M.; Rinella, G. Aglieri; Carassiti, V.; Ceccucci, A.; Gil, E. Cortina; Ramusino, A. Cotta; Dellacasa, G.; Garbolino, S.; Jarron, P.; Kaplon, J.; Kluge, A.; Marchetto, F.; Mapelli, A.; Martin, E.; Mazza, G.; Morel, M.; Noy, M.; Nuessle, G.; Petagna, P.; Petrucci, F.; Perktold, L.; Riedler, P.; Rivetti, A.; Statera, M.; Velghe, B.

The Gigatracker (GTK) is a hybrid silicon pixel detector developed for NA62, the experiment aimed at studying ultra-rare kaon decays at the CERN SPS. Three GTK stations will provide precise momentum and angular measurements on every track of the high intensity NA62 hadron beam with a time-tagging resolution of 150 ps. Multiple scattering and hadronic interactions of beam particles in the GTK have to be minimized to keep background events at acceptable levels, hence the total material budget is fixed to 0.5% X0 per station. In addition the calculated fluence for 100 days of running is 2×1014 1 MeV neq/cm2, comparable to the one expected for the inner trackers of LHC detectors in 10 years of operation. These requirements pose challenges for the development of an efficient and low-mass cooling system, to be operated in vacuum, and on the thinning of read-out chips to 100 μm or less. The most challenging requirement is represented by the time resolution, which can be achieved by carefully compensating for the discriminator time-walk. For this purpose, two complementary read-out architectures have been designed and produced as small-scale prototypes: the first is based on the use of a Time-over-Threshold circuit followed by a TDC shared by a group of pixels, while the other uses a constant-fraction discriminator followed by an on-pixel TDC. The readout pixel ASICs are produced in 130 nm IBM CMOS technology and bump-bonded to 200 μm thick silicon sensors. The Gigatracker detector system is described with particular emphasis on recent experimental results obtained from laboratory and beam tests of prototype bump-bonded assemblies, which show a time resolution of less than 200 ps for single hits.

An air-pressure-free elastomeric valve for integrated nucleic acid analysis by capillary electrophoresis

NASA Astrophysics Data System (ADS)

Jung, Wooseok; Barrett, Matthew; Brooks, Carla; Rivera, Andrew; Birdsell, Dawn N.; Wagner, David M.; Zenhausern, Frederic

2015-12-01

We present a new elastomeric valve for integrated nucleic acid analysis by capillary electrophoresis. The valve functions include metering to capture a designated volume of biological sample into a polymerase chain reaction (PCR) chamber, sealing to preserve the sample during PCR cycling, and transfer of the PCR-products and on-chip formamide post-processing for the analysis of DNA fragments by capillary gel electrophoresis. This new valve differs from prior art polydimethylsiloxane (PDMS) valves in that the valve is not actuated externally by air-pressure or vacuum so that it simplifies a DNA analysis system by eliminating the need for an air-pressure or vacuum source, and off-cartridge solenoid valves, control circuit boards and software. Instead, the new valve is actuated by a thermal cycling peltier assembly integrated within the hardware instrument that tightly comes in contact with a microfluidic cartridge for thermal activation during PCR, so that it spontaneously closes the valve without an additional actuator system. The valve has bumps in the designated locations so that it has a self-alignment that does not require precise alignment of a valve actuator. Moreover, the thickness of the new valve is around 600 μm with an additional bump height of 400 μm so that it is easy to handle and very feasible to fabricate by injection molding compared to other PDMS valves whose thicknesses are around 30-100 μm. The new valve provided over 95% of metering performance in filling the fixed volume of the PCR chamber, preserved over 97% of the sample volume during PCR, and showed very comparable capillary electrophoresis peak heights to the benchtop assay tube controls with very consistent transfer volume of the PCR-product and on-chip formamide. The new valve can perform a core function for integrated nucleic acid analysis by capillary electrophoresis.

Trend Extraction in Functional Data of Amplitudes of R and T Waves in Exercise Electrocardiogram

NASA Astrophysics Data System (ADS)

Cammarota, Camillo; Curione, Mario

The amplitudes of R and T waves of the electrocardiogram (ECG) recorded during the exercise test show both large inter- and intra-individual variability in response to stress. We analyze a dataset of 65 normal subjects undergoing ambulatory test. We model the dataset of R and T series in the framework of functional data, assuming that the individual series are realizations of a non-stationary process, centered at the population trend. We test the time variability of this trend computing a simultaneous confidence band and the zero crossing of its derivative. The analysis shows that the amplitudes of the R and T waves have opposite responses to stress, consisting respectively in a bump and a dip at the early recovery stage. Our findings support the existence of a relationship between R and T wave amplitudes and respectively diastolic and systolic ventricular volumes.

Second Iteration of Photogrammetric Pipeline to Enhance the Accuracy of Image Pose Estimation

NASA Astrophysics Data System (ADS)

Nguyen, T. G.; Pierrot-Deseilligny, M.; Muller, J.-M.; Thom, C.

2017-05-01

In classical photogrammetric processing pipeline, the automatic tie point extraction plays a key role in the quality of achieved results. The image tie points are crucial to pose estimation and have a significant influence on the precision of calculated orientation parameters. Therefore, both relative and absolute orientations of the 3D model can be affected. By improving the precision of image tie point measurement, one can enhance the quality of image orientation. The quality of image tie points is under the influence of several factors such as the multiplicity, the measurement precision and the distribution in 2D images as well as in 3D scenes. In complex acquisition scenarios such as indoor applications and oblique aerial images, tie point extraction is limited while only image information can be exploited. Hence, we propose here a method which improves the precision of pose estimation in complex scenarios by adding a second iteration to the classical processing pipeline. The result of a first iteration is used as a priori information to guide the extraction of new tie points with better quality. Evaluated with multiple case studies, the proposed method shows its validity and its high potiential for precision improvement.

An experimental investigation on the thermal field of overlapping layers in laser-assisted tape winding process

NASA Astrophysics Data System (ADS)

Hosseini, S. M. A.; Baran, I.; Akkerman, R.

2018-05-01

The laser-assisted tape winding (LATW) is an automated process for manufacturing fiber-reinforced thermoplastic tubular products, such as pipes and pressure vessels. Multi-physical phenomena such as heat transfer, mechanical bonding, phase changes and solid mechanics take place during the process. These phenomena need to be understood and described well for an improved product reliability. Temperature is one of the important parameters in this process to control and optimize the product quality which can be employed in an intelligent model-based inline control system. The incoming tape can overlap with the already wounded layer during the process based on the lay-up configuration. In this situation, the incoming tape can step-on or step-off to an already deposited layer/laminate. During the overlapping, the part temperature changes due to the variation of the geometry caused by previously deposited layer, i.e. a bump geometry. In order to qualify the temperature behavior at the bump regions, an experimental set up is designed on a flat laminate. Artificial bumps/steps are formed on the laminate with various thicknesses and fiber orientations. As the laser head experiences the step-on and step-off, the IR (Infra-Red) camera and the embedded thermocouples measure the temperature on the surface and inside the laminate, respectively. During the step-on, a small drop in temperature is observed while in step-off a higher peak in temperature is observed. It can be concluded that the change in the temperature during overlapping is due to the change in laser incident angle made by the bump geometry. The effect of the step thickness on the temperature peak is quantified and found to be significant.

Radiation Belt Electron Energy Spectra Characterization and Evolution Based on the Van Allen Probes Measurements

NASA Astrophysics Data System (ADS)

Zhao, H.; Baker, D. N.; Jaynes, A. N.; Li, X.; Kanekal, S. G.; Blum, L. W.; Schiller, Q. A.; Leonard, T. W.; Elkington, S. R.

2017-12-01

The electron energy spectra, as an important characteristic of radiation belt electrons, provide valuable information on the physical mechanisms affecting different electron populations. Based on the measurements of 30 keV - 10 MeV electrons from MagEIS and REPT instruments on the Van Allen Probes, case studies and statistical analysis of the radiation belt electron energy spectra characterization and evolution have been performed. Generally the radiation belt electron energy spectra can be represented by one of the three types of distributions: exponential, power law, and bump-on-tail. Statistical analysis shows that the exponential spectra are usually dominant in the outer radiation belt; as the geomagnetic storms occur, energy spectra in the outer belt soften at first due to injection of lower-energy electrons and loss of higher-energy electrons, and gradually get harder due to loss of lower-energy electrons and delayed enhancement of higher energy electron fluxes. Power law spectra generally dominate the inner belt and higher L region (L>6) during injections. Bump-on-tail spectra commonly exist inside the plasmasphere following the geomagnetic storms and/or the compression of plasmasphere, while the energy of flux maxima is usually 1.8 MeV as the bump-on-tail spectra form and gradually moves to higher energies as the spectra evolve, with the ratio of flux maxima to minima up to >10. Detailed event study indicates that the appearance of bump-on-tail spectra are mainly due to energy-dependent losses caused by the plasmaspheric hiss wave scattering, while the disappearance of these spectra can be attributed to fast flux enhancements of lower-energy electrons during storms.

Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment.

PubMed

Keegan, Ronan M; McNicholas, Stuart J; Thomas, Jens M H; Simpkin, Adam J; Simkovic, Felix; Uski, Ville; Ballard, Charles C; Winn, Martyn D; Wilson, Keith S; Rigden, Daniel J

2018-03-01

Increasing sophistication in molecular-replacement (MR) software and the rapid expansion of the PDB in recent years have allowed the technique to become the dominant method for determining the phases of a target structure in macromolecular X-ray crystallography. In addition, improvements in bioinformatic techniques for finding suitable homologous structures for use as MR search models, combined with developments in refinement and model-building techniques, have pushed the applicability of MR to lower sequence identities and made weak MR solutions more amenable to refinement and improvement. MrBUMP is a CCP4 pipeline which automates all stages of the MR procedure. Its scope covers everything from the sourcing and preparation of suitable search models right through to rebuilding of the positioned search model. Recent improvements to the pipeline include the adoption of more sensitive bioinformatic tools for sourcing search models, enhanced model-preparation techniques including better ensembling of homologues, and the use of phase improvement and model building on the resulting solution. The pipeline has also been deployed as an online service through CCP4 online, which allows its users to exploit large bioinformatic databases and coarse-grained parallelism to speed up the determination of a possible solution. Finally, the molecular-graphics application CCP4mg has been combined with MrBUMP to provide an interactive visual aid to the user during the process of selecting and manipulating search models for use in MR. Here, these developments in MrBUMP are described with a case study to explore how some of the enhancements to the pipeline and to CCP4mg can help to solve a difficult case.

Aqueous-based thick photoresist removal for bumping applications

NASA Astrophysics Data System (ADS)

Moore, John C.; Brewer, Alex J.; Law, Alman; Pettit, Jared M.

2015-03-01

Cleaning processes account for over 25% of processing in microelectronic manufacturing [1], suggesting electronics to be one of the most chemical intensive markets in commerce. Industry roadmaps exist to reduce chemical exposure, usage, and waste [2]. Companies are encouraged to create a safer working environment, or green factory, and ultimately become certified similar to LEED in the building industry [3]. A significant step in this direction is the integration of aqueous-based photoresist (PR) strippers which eliminate regulatory risks and cut costs by over 50%. One of the largest organic solvent usages is based upon thick PR removal during bumping processes [4-6]. Using market projections and the benefits of recycling, it is estimated that over 1,000 metric tons (mt) of residuals originating from bumping processes are incinerated or sent to a landfill. Aqueous-based stripping would eliminate this disposal while also reducing the daily risks to workers and added permitting costs. Positive-tone PR dissolves in aqueous strippers while negative-tone systems are lifted-off from the substrate, bumps, pillars, and redistribution layers (RDL). While the wafers are further processed and rinsed, the lifted-off PR is pumped from the tank, collected onto a filter, and periodically back-flushed to the trash. The PR solids become a non-hazardous plastic waste while the liquids are mixed with the developer stream, neutralized, filtered, and in most cases, disposed to the sewer. Regardless of PR thickness, removal processes may be tuned to perform in <15min, performing at rates nearly 10X faster than solvents with higher bath lives. A balanced formula is safe for metals, dielectrics, and may be customized to any fab.

Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment

PubMed Central

Keegan, Ronan M.; McNicholas, Stuart J.; Thomas, Jens M. H.; Simpkin, Adam J.; Uski, Ville; Ballard, Charles C.

2018-01-01

Increasing sophistication in molecular-replacement (MR) software and the rapid expansion of the PDB in recent years have allowed the technique to become the dominant method for determining the phases of a target structure in macromolecular X-ray crystallography. In addition, improvements in bioinformatic techniques for finding suitable homologous structures for use as MR search models, combined with developments in refinement and model-building techniques, have pushed the applicability of MR to lower sequence identities and made weak MR solutions more amenable to refinement and improvement. MrBUMP is a CCP4 pipeline which automates all stages of the MR procedure. Its scope covers everything from the sourcing and preparation of suitable search models right through to rebuilding of the positioned search model. Recent improvements to the pipeline include the adoption of more sensitive bioinformatic tools for sourcing search models, enhanced model-preparation techniques including better ensembling of homologues, and the use of phase improvement and model building on the resulting solution. The pipeline has also been deployed as an online service through CCP4 online, which allows its users to exploit large bioinformatic databases and coarse-grained parallelism to speed up the determination of a possible solution. Finally, the molecular-graphics application CCP4mg has been combined with MrBUMP to provide an interactive visual aid to the user during the process of selecting and manipulating search models for use in MR. Here, these developments in MrBUMP are described with a case study to explore how some of the enhancements to the pipeline and to CCP4mg can help to solve a difficult case. PMID:29533225

Feature extraction for document text using Latent Dirichlet Allocation

NASA Astrophysics Data System (ADS)

Prihatini, P. M.; Suryawan, I. K.; Mandia, IN

2018-01-01

Feature extraction is one of stages in the information retrieval system that used to extract the unique feature values of a text document. The process of feature extraction can be done by several methods, one of which is Latent Dirichlet Allocation. However, researches related to text feature extraction using Latent Dirichlet Allocation method are rarely found for Indonesian text. Therefore, through this research, a text feature extraction will be implemented for Indonesian text. The research method consists of data acquisition, text pre-processing, initialization, topic sampling and evaluation. The evaluation is done by comparing Precision, Recall and F-Measure value between Latent Dirichlet Allocation and Term Frequency Inverse Document Frequency KMeans which commonly used for feature extraction. The evaluation results show that Precision, Recall and F-Measure value of Latent Dirichlet Allocation method is higher than Term Frequency Inverse Document Frequency KMeans method. This shows that Latent Dirichlet Allocation method is able to extract features and cluster Indonesian text better than Term Frequency Inverse Document Frequency KMeans method.

Unsteady features of the flow on a bump in transonic environment

NASA Astrophysics Data System (ADS)

Budovsky, A. D.; Sidorenko, A. A.; Polivanov, P. A.; Vishnyakov, O. I.; Maslov, A. A.

2016-10-01

The study deals with experimental investigation of unsteady features of separated flow on a profiled bump in transonic environment. The experiments were conducted in T-325 wind tunnel of ITAM for the following flow conditions: P0 = 1 bar, T0 = 291 K. The base flow around the model was studied by schlieren visualization, steady and unsteady wall pressure measurements and PIV. The experimentally data obtained using PIV are analyzed by Proper Orthogonal Decomposition (POD) technique to investigate the underlying unsteady flow organization, as revealed by the POD eigenmodes. The data obtained show that flow pulsations revealed upstream and downstream of shock wave are correlated and interconnected.

PROBING ELECTRON-CAPTURE SUPERNOVAE: X-RAY BINARIES IN STARBURSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linden, T.; Sepinsky, J. F.; Kalogera, V.

We develop population models of high-mass X-ray binaries (HMXBs) formed after bursts of star formation and we investigate the effect of electron-capture supernovae (ECS) of massive ONeMg white dwarfs and the hypothesis that ECS events are associated with typically low supernova kicks imparted to the nascent neutron stars. We identify an interesting ECS bump in the time evolution of HMXB numbers; this bump is caused by significantly increased production of wind-fed HMXBs 20-60 Myr post-starburst. The amplitude and age extent of the ECS bump depend on the strength of ECS kicks and the mass range of ECS progenitors. We alsomore » find that ECS-HMXBs form through a specific evolutionary channel that is expected to lead to binaries with Be donors in wide orbits. These characteristics, along with their sensitivity to ECS properties, provide us with an intriguing opportunity to probe ECS physics and progenitors through studies of starbursts of different ages. Specifically, the case of the Small Magellanic Cloud, with a significant observed population of Be-HMXBs and starburst activity 30-60 Myr ago, arises as a promising laboratory for understanding the role of ECS in neutron star formation.« less

Multiple Fingers - One Gestalt.

PubMed

Lezkan, Alexandra; Manuel, Steven G; Colgate, J Edward; Klatzky, Roberta L; Peshkin, Michael A; Drewing, Knut

2016-01-01

The Gestalt theory of perception offered principles by which distributed visual sensations are combined into a structured experience ("Gestalt"). We demonstrate conditions whereby haptic sensations at two fingertips are integrated in the perception of a single object. When virtual bumps were presented simultaneously to the right hand's thumb and index finger during lateral arm movements, participants reported perceiving a single bump. A discrimination task measured the bump's perceived location and perceptual reliability (assessed by differential thresholds) for four finger configurations, which varied in their adherence to the Gestalt principles of proximity (small versus large finger separation) and synchrony (virtual spring to link movements of the two fingers versus no spring). According to models of integration, reliability should increase with the degree to which multi-finger cues integrate into a unified percept. Differential thresholds were smaller in the virtual-spring condition (synchrony) than when fingers were unlinked. Additionally, in the condition with reduced synchrony, greater proximity led to lower differential thresholds. Thus, with greater adherence to Gestalt principles, thresholds approached values predicted for optimal integration. We conclude that the Gestalt principles of synchrony and proximity apply to haptic perception of surface properties and that these principles can interact to promote multi-finger integration.

Adaptations for vision in dim light: impulse responses and bumps in nocturnal spider photoreceptor cells (Cupiennius salei Keys).

PubMed

Pirhofer-Walzl, Karin; Warrant, Eric; Barth, Friedrich G

2007-10-01

The photoreceptor cells of the nocturnal spider Cupiennius salei were investigated by intracellular electrophysiology. (1) The responses of photoreceptor cells of posterior median (PM) and anterior median (AM) eyes to short (2 ms) light pulses showed long integration times in the dark-adapted and shorter integration times in the light-adapted state. (2) At very low light intensities, the photoreceptors responded to single photons with discrete potentials, called bumps, of high amplitude (2-20 mV). When measured in profoundly dark-adapted photoreceptor cells of the PM eyes these bumps showed an integration time of 128 +/- 35 ms (n = 7) whereas in dark-adapted photoreceptor cells of AM eyes the integration time was 84 +/- 13 ms (n = 8), indicating that the AM eyes are intrinsically faster than the PM eyes. (3) Long integration times, which improve visual reliability in dim light, and large responses to single photons in the dark-adapted state, contribute to a high visual sensitivity in Cupiennius at night. This conclusion is underlined by a calculation of sensitivity that accounts for both anatomical and physiological characteristics of the eye.

Expanding Medicaid Access without Expanding Medicaid: Why Did Some Nonexpansion States Continue the Primary Care Fee Bump?

PubMed

Wilk, Adam S; Evans, Leigh C; Jones, David K

2018-02-01

Six states that have rejected the Patient Protection and Affordable Care Act's (ACA) Medicaid expansion nonetheless extended the primary care "fee bump," by which the federal government increased Medicaid fees for primary care services up to 100 percent of Medicare fees during 2013-14. We conducted semistructured interviews with leaders in five of these states, as well as in three comparison states, to examine why they would continue a provision of the ACA that moderately expands access at significant state expense while rejecting the expansion and its large federal match, focusing on relevant economic, political, and procedural factors. We found that fee bump extension proposals were more successful where they were dissociated from major national policy debates, actionable with the input of relatively few stakeholder entities, and well aligned with preexisting policy-making structures and decision trends. Republican proposals to cap or reduce federal funding for Medicaid, if enacted, would compel states to contain program costs. In this context, states' established decision-making processes for updating Medicaid fee schedules, which we elucidate in this study, may shape the future of the Medicaid program. Copyright © 2018 by Duke University Press 2018.

Can the bump in the composite spectrum of GRB 910503 be an emission line feature of gamma-ray bursts?

NASA Astrophysics Data System (ADS)

Qin, Yi-Ping; Zhang, Fu-Wen

2005-12-01

Appearing in the composite spectral data of BATSE, EGRET and COMPTEL for GRB 910503, there is a bump at around 1600 keV. We perform a statistical analysis on the spectral data, trying to find out if the bump could be accounted for by a blue-shifted and significantly broadened rest frame line due to the Doppler effect of an expanding fireball surface. We made an F-test and adopted previously proposed criteria. The study reveals that the criteria are well satisfied and the feature can be interpreted as the blue shifted 6.4 keV line. From the fit with this line taken into account, we find the Lorentz factor of this source to be Γ = 116+9-9 (at the 68% confident level, triangleχ2 = 1) and the rest frame spectral peak energy to be E0,p = 2.96+0.24-0.18 keV. Although the existence of the emission line feature requires other independent tests to confirm, the analysis suggests that it is feasible to detect emission line features in the high energy range of GRB spectra when taking into account the Doppler effect of fireball expansion.

Supercritical fluid extraction of 13-cis retinoic acid and its photoisomers from selected pharmaceutical dosage forms.

PubMed

Simmons, B R; Chukwumerije, O; Stewart, J T

1997-11-01

13-Cis retinoic acid (Accutane) was extracted from a cream, gel, capsule and beadlet dosage from using supercritical carbon dioxide modified with 5% methanol as the mobile phase. The pump pressure and the extraction chamber and restrictor temperature were experimentally optimized at 325 atm and 45 degrees C, respectively. A 2.5-min static and 5-min dynamic extraction time were used. The supercritical fluid extraction (SFE) eluent was trapped in methanol, injected into the high-performance liquid chromatographic (HPLC) system, and quantitated by ultraviolet detection at 360 nm. Application of the SFE method to spiked placebo dosage forms gave 13-cis retinoic acid recoveries of 98.8, 98.9, 98.8 and 100% for the cream, gel, capsule and beadlet, respectively, with R.S.D.s in the range 0.6-0.9% (n = 4). Inter-day percent error and precision of the extraction were 1.1-2.0 and 0.2-2.4% (n = 3), respectively, and intra-day percent error and precision were 1.0-3.0 and 0.3-2.1% (n = 8), respectively. Percent error and precision data for spiked celite samples in the 0.05-1.0 microgram ml-1 range were 0.59-4.75 and 1.8-2.1% (n = 3), respectively. The extraction method was applied to commercial 13-cis retinoic acid dosage forms and the results compared to unextracted samples. Linear regression analysis of concentration versus peak height gave a correlation coefficient of 0.9991 with a slope of 7.468 and a y-intercept of 0.1923. The percent error and precision data were 1.3-5.3 and 0.2-1.5% (n = 4), respectively. The photoisomers of 13-cis retinoic acid were also extracted with the method and recoveries of 90.4-92.4% with R.S.D.s of 1.5-3.4% were obtained (n = 4).

Antisolar differential rotation with surface lithium enrichment on the single K-giant V1192 Orionis

NASA Astrophysics Data System (ADS)

Kővári, Zs.; Strassmeier, K. G.; Carroll, T. A.; Oláh, K.; Kriskovics, L.; Kővári, E.; Kovács, O.; Vida, K.; Granzer, T.; Weber, M.

2017-10-01

Context. Stars with about 1-2 solar masses at the red giant branch (RGB) represent an intriguing period of stellar evolution, I.e. when the convective envelope interacts with the fast-rotating core. During these mixing episodes freshly synthesized lithium can come up to the stellar surface along with high angular momentum material. This high angular momentum may alter the surface rotation pattern. Aims: The single rapidly rotating K-giant V1192 Ori is revisited to determine its surface differential rotation, lithium abundance, and basic stellar properties such as a precise rotation period. The aim is to independently verify the antisolar differential rotation of the star and possibly find a connection to the surface lithium abundance. Methods: We applied time-series Doppler imaging to a new multi-epoch data set. Altogether we reconstructed 11 Doppler images from spectroscopic data collected with the STELLA robotic telescope between 2007-2016. We used our inversion code iMap to reconstruct all stellar surface maps. We extracted the differential rotation from these images by tracing systematic spot migration as a function of stellar latitude from consecutive image cross-correlations. Results: The position of V1192 Ori in the Hertzsprung-Russell diagram suggests that the star is in the helium core-burning phase just leaving the RGB bump. We measure A(Li)NLTE = 1.27, I.e. a value close to the anticipated transition value of 1.5 from Li-normal to Li-rich giants. Doppler images reveal extended dark areas arranged quasi-evenly along an equatorial belt. No cool polar spot is found during the investigated epoch. Spot displacements clearly suggest antisolar surface differential rotation with α = - 0.11 ± 0.02 shear coefficient. Conclusions: The surface Li enrichment and the peculiar surface rotation pattern may indicate a common origin. Based on data obtained with the STELLA robotic observatory in Tenerife, an AIP facility jointly operated by AIP and IAC.

Figure Text Extraction in Biomedical Literature

PubMed Central

Kim, Daehyun; Yu, Hong

2011-01-01

Background Figures are ubiquitous in biomedical full-text articles, and they represent important biomedical knowledge. However, the sheer volume of biomedical publications has made it necessary to develop computational approaches for accessing figures. Therefore, we are developing the Biomedical Figure Search engine (http://figuresearch.askHERMES.org) to allow bioscientists to access figures efficiently. Since text frequently appears in figures, automatically extracting such text may assist the task of mining information from figures. Little research, however, has been conducted exploring text extraction from biomedical figures. Methodology We first evaluated an off-the-shelf Optical Character Recognition (OCR) tool on its ability to extract text from figures appearing in biomedical full-text articles. We then developed a Figure Text Extraction Tool (FigTExT) to improve the performance of the OCR tool for figure text extraction through the use of three innovative components: image preprocessing, character recognition, and text correction. We first developed image preprocessing to enhance image quality and to improve text localization. Then we adapted the off-the-shelf OCR tool on the improved text localization for character recognition. Finally, we developed and evaluated a novel text correction framework by taking advantage of figure-specific lexicons. Results/Conclusions The evaluation on 382 figures (9,643 figure texts in total) randomly selected from PubMed Central full-text articles shows that FigTExT performed with 84% precision, 98% recall, and 90% F1-score for text localization and with 62.5% precision, 51.0% recall and 56.2% F1-score for figure text extraction. When limiting figure texts to those judged by domain experts to be important content, FigTExT performed with 87.3% precision, 68.8% recall, and 77% F1-score. FigTExT significantly improved the performance of the off-the-shelf OCR tool we used, which on its own performed with 36.6% precision, 19.3% recall, and 25.3% F1-score for text extraction. In addition, our results show that FigTExT can extract texts that do not appear in figure captions or other associated text, further suggesting the potential utility of FigTExT for improving figure search. PMID:21249186

Figure text extraction in biomedical literature.

PubMed

Kim, Daehyun; Yu, Hong

2011-01-13

Figures are ubiquitous in biomedical full-text articles, and they represent important biomedical knowledge. However, the sheer volume of biomedical publications has made it necessary to develop computational approaches for accessing figures. Therefore, we are developing the Biomedical Figure Search engine (http://figuresearch.askHERMES.org) to allow bioscientists to access figures efficiently. Since text frequently appears in figures, automatically extracting such text may assist the task of mining information from figures. Little research, however, has been conducted exploring text extraction from biomedical figures. We first evaluated an off-the-shelf Optical Character Recognition (OCR) tool on its ability to extract text from figures appearing in biomedical full-text articles. We then developed a Figure Text Extraction Tool (FigTExT) to improve the performance of the OCR tool for figure text extraction through the use of three innovative components: image preprocessing, character recognition, and text correction. We first developed image preprocessing to enhance image quality and to improve text localization. Then we adapted the off-the-shelf OCR tool on the improved text localization for character recognition. Finally, we developed and evaluated a novel text correction framework by taking advantage of figure-specific lexicons. The evaluation on 382 figures (9,643 figure texts in total) randomly selected from PubMed Central full-text articles shows that FigTExT performed with 84% precision, 98% recall, and 90% F1-score for text localization and with 62.5% precision, 51.0% recall and 56.2% F1-score for figure text extraction. When limiting figure texts to those judged by domain experts to be important content, FigTExT performed with 87.3% precision, 68.8% recall, and 77% F1-score. FigTExT significantly improved the performance of the off-the-shelf OCR tool we used, which on its own performed with 36.6% precision, 19.3% recall, and 25.3% F1-score for text extraction. In addition, our results show that FigTExT can extract texts that do not appear in figure captions or other associated text, further suggesting the potential utility of FigTExT for improving figure search.

Optimisation and validation of the microwave-assisted extraction of phenolic compounds from rice grains.

PubMed

Setyaningsih, W; Saputro, I E; Palma, M; Barroso, C G

2015-02-15

A new microwave-assisted extraction (MAE) method has been investigated for the extraction of phenolic compounds from rice grains. The experimental conditions studied included temperature (125-175°C), microwave power (500-1000W), time (5-15min), solvent (10-90% EtOAc in MeOH) and solvent-to-sample ratio (10:1 to 20:1). The extraction variables were optimised by the response surface methodology. Extraction temperature and solvent were found to have a highly significant effect on the response value (p<0.0005) and the extraction time also had a significant effect (p<0.05). The optimised MAE conditions were as follows: extraction temperature 185°C, microwave power 1000W, extraction time 20min, solvent 100% MeOH, and solvent-to-sample ratio 10:1. The developed method had a high precision (in terms of CV: 5.3% for repeatability and 5.5% for intermediate precision). Finally, the new method was applied to real samples in order to investigate the presence of phenolic compounds in a wide variety of rice grains. Copyright © 2014 Elsevier Ltd. All rights reserved.

Unified, flavor symmetric explanation for the tt asymmetry and Wjj excess at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Ann E.; Roy, Tuhin S.; Okui, Takemichi

2011-11-01

We present a simple, perturbative, and renormalizable model with a flavor symmetry which can explain both the tt forward-backward asymmetry and the bump feature present in the dijet mass distribution of the W+jj sample in the range 120-160 GeV that was recently reported by the CDF collaboration. The flavor symmetry not only ensures the flavor/CP safety of the model, but also relates the two anomalies unambiguously. It predicts a comparable forward-backward asymmetry in cc. The forward-backward asymmetry in bb is, however, small. A bump in the dijet mass distribution in Z+jj sample is also predicted but with a suppressed crossmore » section.« less

Fast, High-Precision Readout Circuit for Detector Arrays

NASA Technical Reports Server (NTRS)

Rider, David M.; Hancock, Bruce R.; Key, Richard W.; Cunningham, Thomas J.; Wrigley, Chris J.; Seshadri, Suresh; Sander, Stanley P.; Blavier, Jean-Francois L.

2013-01-01

The GEO-CAPE mission described in NASA's Earth Science and Applications Decadal Survey requires high spatial, temporal, and spectral resolution measurements to monitor and characterize the rapidly changing chemistry of the troposphere over North and South Americas. High-frame-rate focal plane arrays (FPAs) with many pixels are needed to enable such measurements. A high-throughput digital detector readout integrated circuit (ROIC) that meets the GEO-CAPE FPA needs has been developed, fabricated, and tested. The ROIC is based on an innovative charge integrating, fast, high-precision analog-to-digital circuit that is built into each pixel. The 128×128-pixel ROIC digitizes all 16,384 pixels simultaneously at frame rates up to 16 kHz to provide a completely digital output on a single integrated circuit at an unprecedented rate of 262 million pixels per second. The approach eliminates the need for off focal plane electronics, greatly reducing volume, mass, and power compared to conventional FPA implementations. A focal plane based on this ROIC will require less than 2 W of power on a 1×1-cm integrated circuit. The ROIC is fabricated of silicon using CMOS technology. It is designed to be indium bump bonded to a variety of detector materials including silicon PIN diodes, indium antimonide (InSb), indium gallium arsenide (In- GaAs), and mercury cadmium telluride (HgCdTe) detector arrays to provide coverage over a broad spectral range in the infrared, visible, and ultraviolet spectral ranges.

In situ Orbit Extraction from Live, High Precision Collisionless Simulations of Systems Formed by Cold Collapse

NASA Astrophysics Data System (ADS)

Noriega-Mendoza, H.; Aguilar, L. A.

2018-04-01

We performed high precision, N-body simulations of the cold collapse of initially spherical, collisionless systems using the GYRFALCON code of Dehnen (2000). The collapses produce very prolate spheroidal configurations. After the collapse, the systems are simulated for 85 and 170 half-mass radius dynamical timescales, during which energy conservation is better than 0.005%. We use this period to extract individual particle orbits directly from the simulations. We then use the TAXON code of Carpintero and Aguilar (1998) to classify 1 to 1.5% of the extracted orbits from our final, relaxed configurations: less than 15% are chaotic orbits, 30% are box orbits and 60% are tube orbits (long and short axis). Our goal has been to prove that direct orbit extraction is feasible, and that there is no need to "freeze" the final N-body system configuration to extract a time-independent potential.

High recall document content extraction

NASA Astrophysics Data System (ADS)

An, Chang; Baird, Henry S.

2011-01-01

We report methodologies for computing high-recall masks for document image content extraction, that is, the location and segmentation of regions containing handwriting, machine-printed text, photographs, blank space, etc. The resulting segmentation is pixel-accurate, which accommodates arbitrary zone shapes (not merely rectangles). We describe experiments showing that iterated classifiers can increase recall of all content types, with little loss of precision. We also introduce two methodological enhancements: (1) a multi-stage voting rule; and (2) a scoring policy that views blank pixels as a "don't care" class with other content classes. These enhancements improve both recall and precision, achieving at least 89% recall and at least 87% precision among three content types: machine-print, handwriting, and photo.

Miniaturization of Micro-Solder Bumps and Effect of IMC on Stress Distribution

NASA Astrophysics Data System (ADS)

Choudhury, Soud Farhan; Ladani, Leila

2016-07-01

As the joints become smaller in more advanced packages and devices, intermetallic (IMCs) volume ratio increases, which significantly impacts the overall mechanical behavior of joints. The existence of only a few grains of Sn (Tin) and IMC materials results in anisotropic elastic and plastic behavior which is not detectable using conventional finite element (FE) simulation with average properties for polycrystalline material. In this study, crystal plasticity finite element (CPFE) simulation is used to model the whole joint including copper, Sn solder and Cu6Sn5 IMC material. Experimental lap-shear test results for solder joints from the literature were used to validate the models. A comparative analysis between traditional FE, CPFE and experiments was conducted. The CPFE model was able to correlate the experiments more closely compared to traditional FE analysis because of its ability to capture micro-mechanical anisotropic behavior. Further analysis was conducted to evaluate the effect of IMC thickness on stress distribution in micro-bumps using a systematic numerical experiment with IMC thickness ranging from 0% to 80%. The analysis was conducted on micro-bumps with single crystal Sn and bicrystal Sn. The overall stress distribution and shear deformation changes as the IMC thickness increases. The model with higher IMC thickness shows a stiffer shear response, and provides a higher shear yield strength.

Soldering-induced Cu diffusion and intermetallic compound formation between Ni/Cu under bump metallization and SnPb flip-chip solder bumps

NASA Astrophysics Data System (ADS)

Huang, Chien-Sheng; Jang, Guh-Yaw; Duh, Jenq-Gong

2004-04-01

Nickel-based under bump metallization (UBM) has been widely used as a diffusion barrier to prevent the rapid reaction between the Cu conductor and Sn-based solders. In this study, joints with and without solder after heat treatments were employed to evaluate the diffusion behavior of Cu in the 63Sn-37Pb/Ni/Cu/Ti/Si3N4/Si multilayer structure. The atomic flux of Cu diffused through Ni was evaluated from the concentration profiles of Cu in solder joints. During reflow, the atomic flux of Cu was on the order of 1015-1016 atoms/cm2s. However, in the assembly without solder, no Cu was detected on the surface of Ni even after ten cycles of reflow. The diffusion behavior of Cu during heat treatments was studied, and the soldering-process-induced Cu diffusion through Ni metallization was characterized. In addition, the effect of Cu content in the solder near the solder/intermetallic compound (IMC) interface on interfacial reactions between the solder and the Ni/Cu UBM was also discussed. It is evident that the (Cu,Ni)6Sn5 IMC might form as the concentration of Cu in the Sn-Cu-Ni alloy exceeds 0.6 wt.%.

Condensation on Slippery Asymmetric Bumps

NASA Astrophysics Data System (ADS)

Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna

Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.

Condensation on Slippery Asymmetric Bumps

NASA Astrophysics Data System (ADS)

Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna

2016-11-01

Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.

Indium-bump-free antimonide superlattice membrane detectors on silicon substrates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zamiri, M., E-mail: mzamiri@chtm.unm.edu, E-mail: skrishna@chtm.unm.edu; Klein, B.; Schuler-Sandy, T.

2016-02-29

We present an approach to realize antimonide superlattices on silicon substrates without using conventional Indium-bump hybridization. In this approach, PIN superlattices are grown on top of a 60 nm Al{sub 0.6}Ga{sub 0.4}Sb sacrificial layer on a GaSb host substrate. Following the growth, the individual pixels are transferred using our epitaxial-lift off technique, which consists of a wet-etch to undercut the pixels followed by a dry-stamp process to transfer the pixels to a silicon substrate prepared with a gold layer. Structural and optical characterization of the transferred pixels was done using an optical microscope, scanning electron microscopy, and photoluminescence. The interface betweenmore » the transferred pixels and the new substrate was abrupt, and no significant degradation in the optical quality was observed. An Indium-bump-free membrane detector was then fabricated using this approach. Spectral response measurements provided a 100% cut-off wavelength of 4.3 μm at 77 K. The performance of the membrane detector was compared to a control detector on the as-grown substrate. The membrane detector was limited by surface leakage current. The proposed approach could pave the way for wafer-level integration of photonic detectors on silicon substrates, which could dramatically reduce the cost of these detectors.« less

Distributions of p-values smaller than .05 in psychology: what is going on?

PubMed Central

van Aert, Robbie C.M.; Nuijten, Michèle B.; Wicherts, Jelte M.; van Assen, Marcel A.L.M.

2016-01-01

Previous studies provided mixed findings on pecularities in p-value distributions in psychology. This paper examined 258,050 test results across 30,710 articles from eight high impact journals to investigate the existence of a peculiar prevalence of p-values just below .05 (i.e., a bump) in the psychological literature, and a potential increase thereof over time. We indeed found evidence for a bump just below .05 in the distribution of exactly reported p-values in the journals Developmental Psychology, Journal of Applied Psychology, and Journal of Personality and Social Psychology, but the bump did not increase over the years and disappeared when using recalculated p-values. We found clear and direct evidence for the QRP “incorrect rounding of p-value” (John, Loewenstein & Prelec, 2012) in all psychology journals. Finally, we also investigated monotonic excess of p-values, an effect of certain QRPs that has been neglected in previous research, and developed two measures to detect this by modeling the distributions of statistically significant p-values. Using simulations and applying the two measures to the retrieved test results, we argue that, although one of the measures suggests the use of QRPs in psychology, it is difficult to draw general conclusions concerning QRPs based on modeling of p-value distributions. PMID:27077017

Precision probes of QCD at high energies

NASA Astrophysics Data System (ADS)

Alioli, Simone; Farina, Marco; Pappadopulo, Duccio; Ruderman, Joshua T.

2017-07-01

New physics, that is too heavy to be produced directly, can leave measurable imprints on the tails of kinematic distributions at the LHC. We use energetic QCD processes to perform novel measurements of the Standard Model (SM) Effective Field Theory. We show that the dijet invariant mass spectrum, and the inclusive jet transverse momentum spectrum, are sensitive to a dimension 6 operator that modifies the gluon propagator at high energies. The dominant effect is constructive or destructive interference with SM jet production. We compare differential next-to-leading order predictions from POWHEG to public 7 TeV jet data, including scale, PDF, and experimental uncertainties and their respective correlations. We constrain a New Physics (NP) scale of 3.5 TeV with current data. We project the reach of future 13 and 100 TeV measurements, which we estimate to be sensitive to NP scales of 8 and 60 TeV, respectively. As an application, we apply our bounds to constrain heavy vector octet colorons that couple to the QCD current. We project that effective operators will surpass bump hunts, in terms of coloron mass reach, even for sequential couplings.

First demonstration of the fast-to-slow corrector current shift in the NSLS-II storage ring

DOE PAGES

Yang, Xi; Tian, Yuke; Yu, Li Hua; ...

2018-04-01

In order to realize the full benefits of the high brightness and ultra-small beam sizes of NSLS-II, it is essential that the photon beams are exceedingly stable. In the circumstances of implementing local bumps, changing ID gaps, and long term drifting, the fast orbit feedback (FOFB) requires shifting the fast corrector strengths to the slow correctors to prevent the fast corrector saturation and to make the beam orbit stable in the sub-micron level. As the result, a reliable and precise technique of fast-to-slow corrector strength shift has been developed and tested at NSLS-II. This technique is based on the fastmore » corrector response to the slow corrector change when the FOFB is on. In this article, the shift technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented. The maximum fast corrector current was reduced from greater than 0.45 A to less than 0.04 A with the orbit perturbation within ±1 μm.« less

First demonstration of the fast-to-slow corrector current shift in the NSLS-II storage ring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xi; Tian, Yuke; Yu, Li Hua

In order to realize the full benefits of the high brightness and ultra-small beam sizes of NSLS-II, it is essential that the photon beams are exceedingly stable. In the circumstances of implementing local bumps, changing ID gaps, and long term drifting, the fast orbit feedback (FOFB) requires shifting the fast corrector strengths to the slow correctors to prevent the fast corrector saturation and to make the beam orbit stable in the sub-micron level. As the result, a reliable and precise technique of fast-to-slow corrector strength shift has been developed and tested at NSLS-II. This technique is based on the fastmore » corrector response to the slow corrector change when the FOFB is on. In this article, the shift technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented. The maximum fast corrector current was reduced from greater than 0.45 A to less than 0.04 A with the orbit perturbation within ±1 μm.« less

Dust in the small Magellanic cloud. 1: Interstellar polarization and extinction data

NASA Technical Reports Server (NTRS)

Magalhaes, A. M.; Rodrigues, C. V.; Coyne, C. V.; Piirola, V.

1996-01-01

The typical extinction curve for the Small Magellanic Cloud (SMC), in contrast to that for the Galaxy, has no bump at 2175 A and has a steeper rise into the far ultraviolet. For the Galaxy the interpretation of the extinction and, therefore, the dust content of the interstellar medium has been greatly assisted by measurements of the wavelength dependence of the polarization. For the SMC no such measurements existed. Therefore, to further elucidate the dust properties in the SMC we have for the first time measured linear polarization with five colors in the optical region of the spectrum for a sample of reddened stars. For two of these stars, for which there were no existing UV spectrophotometric measurements, but for which we measured a relatively large polarization, we have also obtained data from the International Ultraviolet Explorer (IUE) in order to study the extinction. We also attempt to correlate the SMC extinction and polarization data. The main results are: the wavelength of maximum polarization, lambda(sub max), in the SMC is typically smaller than that in the Galaxy; however, AZC 456, which shows the UV extinction bump, has a lambda(sub max) typical of that in the Galaxy, but its polarization curve is narrower and its bump is shifted to shorter wavelengths as compared to the Galaxy; and from an analysis of both the extinction and polarization data it appears that the SMC has typically smaller grains than those in the Galaxy. The absence of the extinction bump in the SMC has generally been thought to imply a lower carbon abundance in the SMC compared to the Galaxy. We interpret our results to mean that te size distribution of the interstellar grains, and not only the carbon abundance, is different in the SMC as compared to the Galaxy. In Paper 2 we present dust model fits to these observations.

HUBBLE SPACE TELESCOPE MORPHOLOGIES OF z {approx} 2 DUST-OBSCURED GALAXIES. II. BUMP SOURCES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bussmann, R. S.; Dey, Arjun; Lotz, J.

We present Hubble Space Telescope imaging of 22 ultra-luminous infrared galaxies (ULIRGs) at z {approx} 2 with extremely red R - [24] colors (called dust-obscured galaxies, or DOGs) which have a local maximum in their spectral energy distribution (SED) at rest-frame 1.6 {mu}m associated with stellar emission. These sources, which we call 'bump DOGs', have star formation rates (SFRs) of 400-4000 M{sub sun} yr{sup -1} and have redshifts derived from mid-IR spectra which show strong polycyclic aromatic hydrocarbon emission-a sign of vigorous ongoing star formation. Using a uniform morphological analysis, we look for quantifiable differences between bump DOGs, power-law DOGsmore » (Spitzer-selected ULIRGs with mid-IR SEDs dominated by a power law and spectral features that are more typical of obscured active galactic nuclei than starbursts), submillimeter-selected galaxies, and other less-reddened ULIRGs from the Spitzer Extragalactic First Look Survey. Bump DOGs are larger than power-law DOGs (median Petrosian radius of 8.4 {+-} 2.7 kpc versus 5.5 {+-} 2.3 kpc) and exhibit more diffuse and irregular morphologies (median M{sub 20} of -1.08 {+-} 0.05 versus -1.48 {+-} 0.05). These trends are qualitatively consistent with expectations from simulations of major mergers in which merging systems during the peak SFR period evolve from M{sub 20} = -1.0 to M{sub 20} = -1.7. Less-obscured ULIRGs (i.e., non-DOGs) tend to have more regular, centrally peaked, single-object morphologies rather than diffuse and irregular morphologies. This distinction in morphologies may imply that less-obscured ULIRGs sample the merger near the end of the peak SFR period. Alternatively, it may indicate that the intense star formation in these less-obscured ULIRGs is not the result of a recent major merger.« less

Deep Photometry of GRB 041006 Afterglow: Hypernova Bump at Redshift z = 0.716

NASA Astrophysics Data System (ADS)

Stanek, K. Z.; Garnavich, P. M.; Nutzman, P. A.; Hartman, J. D.; Garg, A.; Adelberger, K.; Berlind, P.; Bonanos, A. Z.; Calkins, M. L.; Challis, P.; Gaudi, B. S.; Holman, M. J.; Kirshner, R. P.; McLeod, B. A.; Osip, D.; Pimenova, T.; Reiprich, T. H.; Romanishin, W.; Spahr, T.; Tegler, S. C.; Zhao, X.

2005-06-01

We present deep optical photometry of the afterglow of gamma-ray burst (GRB) 041006 and its associated hypernova obtained over 65 days after detection (55 R-band epochs on 10 different nights). Our early data (t<4 days) joined with published GCN data indicate a steepening decay, approaching Fν~t-0.6 at early times (t<<1 day) and Fν~t-1.3 at late times. The break at tb=0.16+/-0.04 days is the earliest reported jet break among all GRB afterglows. During our first night, we obtained 39 exposures spanning 2.15 hr from 0.62 to 0.71 days after the burst that reveal a smooth afterglow, with an rms deviation of 0.024 mag from the local power-law fit, consistent with photometric errors. After t~4 days, the decay slows considerably, and the light curve remains approximately flat at R~24 mag for a month before decaying by another magnitude to reach R~25 mag 2 months after the burst. This ``bump'' is well fit by a k-corrected light curve of supernova SN 1998bw, but only if stretched by a factor of 1.38 in time. In comparison with the other GRB-related SN bumps, GRB 041006 stakes out new parameter space for GRBs/SNe, with a very bright and significantly stretched late-time SN light curve. Within a small sample of fairly well observed GRB/SN bumps, we see a hint of a possible correlation between their peak luminosity and their ``stretch factor,'' broadly similar to the well-studied Phillips relation for the Type Ia supernovae. Based on data from the MMT Observatory 6.5 m telescope, the 1.8 m Vatican Advanced Technology Telescope, the Magellan 6.5 m Baade and Clay telescopes, and the Keck II 10 m telescope.

The bumpy light curve of Type IIn supernova iPTF13z over 3 years

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nyholm, A.; Sollerman, J.; Taddia, F.

A core-collapse (CC) supernova (SN) of Type IIn is dominated by the interaction of SN ejecta with the circumstellar medium (CSM). Some SNe IIn (e.g. SN 2006jd) have episodes of re-brightening ("bumps") in their light curves. We present iPTF13z, a Type IIn SN discovered on 2013 February 1 by the intermediate Palomar Transient Factory (iPTF). This SN showed at least five bumps in its declining light curve between 130 and 750 days after discovery. We analyse this peculiar behaviour and try to infer the properties of the CSM, of the SN explosion, and the nature of the progenitor star. Wemore » obtained multi-band optical photometry for over 1000 days after discovery with the P48 and P60 telescopes at Palomar Observatory. We obtained low-resolution optical spectra during the same period. We did an archival search for progenitor outbursts. We analyse the photometry and the spectra, and compare iPTF13z to other SNe IIn. In particular we derive absolute magnitudes, colours, a pseudo-bolometric light curve, and the velocities of the different components of the spectral lines. A simple analytical model is used to estimate the properties of the CSM. iPTF13z had a light curve peaking at M r ≤ 18.3 mag. The five bumps during its decline phase had amplitudes ranging from 0.4 to 0.9 mag and durations between 20 and 120 days. The most prominent bumps appeared in all the different optical bands, when covered. The spectra of this SN showed typical SN IIn characteristics, with emission lines of Hα (with broad component FWHM ~ 10 3 - 10 4 km s -1 and narrow component FWHM ~ 10 2 km s -1 ) and He i, but also with Fe ii, Ca ii, Na i D and Hβ P Cygni profiles (with velocities of ~ 10 3 km s -1). A pre-explosion outburst was identified lasting ≳ 50 days, with M r ≤ 15 mag around 210 days before discovery. Large, variable progenitor mass-loss rates (≳ 0.01M ⊙ yr -1) and CSM densities (10 -16 g cm -3) are derived. The SN was hosted by a metal-poor dwarf galaxy at redshift z = 0.0328. We suggest that the light curve bumps of iPTF13z arose from SN ejecta interacting with denser regions in the CSM, possibly produced by the eruptions of a luminous blue variable progenitor star.« less

A simple crunching of the AGS 'bare' machine ORM data - February 2007 - to extract some aspects of AGS transverse coupling at injection and extraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahrens, L.

2010-11-01

The objective of this note is to (once again) explore the AGS 'ORM' (orbit response matrix) data taken (by Operations) early during the 2007 run with an AGS bare machine and gold beam. Indeed the present motivation is to extract as much information about the AGS inherent transverse coupling as possible - from general arguments and the copious ORM data. And taking this one step further, (though not accomplished yet) the goal really should be to tell the model how to describe this coupling. 'Bare' as used here means the AGS with no quadrupole, sextupole or octupole magnets powered. Onlymore » the main (combined-function) magnet string and dipole bumps necessary to optimize beam survival are powered. 'ORM data' means the systematic recording of the equilibrium orbit beam position monitor response to powering individual dipole corrector magnets. The 'matrix' results from looking at the effect of each of the (12 superperiods X 4 dipoles per superperiod) 'kicks' on each of the (12 X 6) pick up electrodes (pues) in each transverse plane. So then we have two (48 X 72) matrices of numbers from the ORM data. (Though 'pue' usually refers to the hardware in the vacuum chamber and 'bpm' to the beam position monitoring system, the two labels will be used casually here.) The exercise is carried out at two magnet rigidities, injection (AGS field {approx}434 Gauss) and extraction to RHIC ({approx}9730 Gauss), - a ratio of rigidities of about 22.4. Since we stick with a bare machine, we are also stuck with the bare tunes which means the tunes are rather close together and near 8.75. Injection: (h,v) {approx} (8.73, 8.76).« less

Total flavonoids content in the raw material and aqueous extractives from Bauhinia monandra Kurz (Caesalpiniaceae).

PubMed

Fernandes, Ana Josane Dantas; Ferreira, Magda Rhayanny Assunção; Randau, Karina Perrelli; de Souza, Tatiane Pereira; Soares, Luiz Alberto Lira

2012-01-01

The aim of this work was to evaluate the spectrophotometric methodology for determining the total flavonoid content (TFC) in herbal drug and derived products from Bauhinia monandra Kurz. Several analytical parameters from this method grounded on the complex formed between flavonoids and AlCl₃ were evaluated such as herbal amount (0.25 to 1.25 g); solvent composition (ethanol 40 to 80%, v/v); as well as the reaction time and AlCl₃ concentration (2 to 9%, w/v). The method was adjusted to aqueous extractives and its performance studied through precision, linearity and preliminary robustness. The results showed an important dependence of the method response from reaction time, AlCl₃ concentration, sample amount, and solvent mixture. After choosing the optimized condition, the method was applied for the matrixes (herbal material and extractives), showing precision lower than 5% (for both parameters repeatability and intermediate precision), coefficient of determination higher than 0.99, and no important influence could be observed for slight variations from wavelength or AlCl₃ concentration. Thus, it could be concluded that the evaluated analytical procedure was suitable to quantify the total flavonoid content in raw material and aqueous extractives from leaves of B. monandra.

Automatic extraction of relations between medical concepts in clinical texts

PubMed Central

Harabagiu, Sanda; Roberts, Kirk

2011-01-01

Objective A supervised machine learning approach to discover relations between medical problems, treatments, and tests mentioned in electronic medical records. Materials and methods A single support vector machine classifier was used to identify relations between concepts and to assign their semantic type. Several resources such as Wikipedia, WordNet, General Inquirer, and a relation similarity metric inform the classifier. Results The techniques reported in this paper were evaluated in the 2010 i2b2 Challenge and obtained the highest F1 score for the relation extraction task. When gold standard data for concepts and assertions were available, F1 was 73.7, precision was 72.0, and recall was 75.3. F1 is defined as 2*Precision*Recall/(Precision+Recall). Alternatively, when concepts and assertions were discovered automatically, F1 was 48.4, precision was 57.6, and recall was 41.7. Discussion Although a rich set of features was developed for the classifiers presented in this paper, little knowledge mining was performed from medical ontologies such as those found in UMLS. Future studies should incorporate features extracted from such knowledge sources, which we expect to further improve the results. Moreover, each relation discovery was treated independently. Joint classification of relations may further improve the quality of results. Also, joint learning of the discovery of concepts, assertions, and relations may also improve the results of automatic relation extraction. Conclusion Lexical and contextual features proved to be very important in relation extraction from medical texts. When they are not available to the classifier, the F1 score decreases by 3.7%. In addition, features based on similarity contribute to a decrease of 1.1% when they are not available. PMID:21846787

Heroin: MedlinePlus Health Topic

MedlinePlus

... flashes with goose bumps. NIH: National Institute on Drug Abuse Start Here DrugFacts: Heroin (National Institute on Drug Abuse) Also in Spanish Heroin (Drug Enforcement Administration) Heroin ( ...

High-frequency internal waves and thick bottom mixed layers observed by gliders in the Gulf Stream

NASA Astrophysics Data System (ADS)

Todd, Robert E.

2017-06-01

Autonomous underwater gliders are conducting high-resolution surveys within the Gulf Stream along the U.S. East Coast. Glider surveys reveal two mechanisms by which energy is extracted from the Gulf Stream as it flows over the Blake Plateau, a portion of the outer continental shelf between Florida and North Carolina where bottom depths are less than 1000 m. Internal waves with vertical velocities exceeding 0.1 m s-1 and frequencies just below the local buoyancy frequency are routinely found over the Blake Plateau, particularly near the Charleston Bump, a prominent topographic feature. These waves are likely internal lee waves generated by the subinertial Gulf Stream flow over the irregular bathymetry of the outer continental shelf. Bottom mixed layers with O(100) m thickness are also frequently encountered; these thick bottom mixed layers likely form in the lee of topography due to enhanced turbulence generated by O(1) m s-1 near-bottom flows.

Low-temperature specific heat of the quasi-two-dimensional charge-density wave compound KMo6O17

NASA Astrophysics Data System (ADS)

Wang, Junfeng; Xiong, Rui; Yin, Di; Li, Changzhen; Tang, Zheng; Wang, Ququan; Shi, Jing; Wang, Yue; Wen, Haihu

2006-05-01

Low temperature specific heat (Cp) of quasi-two-dimensional charge-density wave (CDW) compound KMo6O17 has been studied by a relaxation method from 2to48K under zero and 12T magnetic fields. The results show that no specific heat anomaly is found at 16K under both zero and 12T magnetic fields, although an anomaly is clearly observed in the resistivity and magnetoresistance measurements. From the data between 2 and 4K , the density of states at Fermi level is estimated as 0.2eV-1permolecule and the Debye temperature is extracted to be 418K . A bump appearing in Cp/T3 is found between 4 and 48K centered around 12.5-15K , indicating that the phason excitations contribute to the total specific heat similarly as in quasi-one-dimensional CDW conductors. Using a modified Debye model, a pinning frequency of 0.73THz for KMo6O17 is estimated from the phason contribution.

Extracting Related Words from Anchor Text Clusters by Focusing on the Page Designer's Intention

NASA Astrophysics Data System (ADS)

Liu, Jianquan; Chen, Hanxiong; Furuse, Kazutaka; Ohbo, Nobuo

Approaches for extracting related words (terms) by co-occurrence work poorly sometimes. Two words frequently co-occurring in the same documents are considered related. However, they may not relate at all because they would have no common meanings nor similar semantics. We address this problem by considering the page designer’s intention and propose a new model to extract related words. Our approach is based on the idea that the web page designers usually make the correlative hyperlinks appear in close zone on the browser. We developed a browser-based crawler to collect “geographically” near hyperlinks, then by clustering these hyperlinks based on their pixel coordinates, we extract related words which can well reflect the designer’s intention. Experimental results show that our method can represent the intention of the web page designer in extremely high precision. Moreover, the experiments indicate that our extracting method can obtain related words in a high average precision.

Dynamics and Afterglow Light Curves of Gamma-Ray Burst Blast Waves Encountering a Density Bump or Void

NASA Astrophysics Data System (ADS)

Uhm, Z. Lucas; Zhang, Bing

2014-07-01

We investigate the dynamics and afterglow light curves of gamma-ray burst blast waves that encounter various density structures (such as bumps, voids, or steps) in the surrounding ambient medium. We present and explain the characteristic response features that each type of density structure in the medium leaves on the forward shock (FS) and reverse shock (RS) dynamics for blast waves with either a long-lived or short-lived RS. We show that when the ambient medium density drops, the blast waves exhibit in some cases a period of an actual acceleration (even during their deceleration stage) due to adiabatic cooling of blast waves. Comparing numerical examples that have different shapes of bumps or voids, we propose a number of consistency tests that must be satisfied by correct modeling of blast waves. Our model results successfully pass these tests. Employing a Lagrangian description of blast waves, we perform a sophisticated calculation of afterglow emission. We show that as a response to density structures in the ambient medium, the RS light curves produce more significant variations than the FS light curves. Some observed features (such as rebrightenings, dips, or slow wiggles) can be more easily explained within the RS model. We also discuss the origin of these different features imprinted on the FS and RS light curves.

Search for the Antineutrino rest mass in the tritium beta decay

NASA Astrophysics Data System (ADS)

Lobashev, V. M.

Status and results of the tritium beta spectrum measurement on the “Troitsk ν-mass” set-up are discussed. Measurements carried out in 1994 to 1997 provided the lowest upper limit for electron antineutrino rest mass in the direct kinematics approach. Analysis of the spectrum revealed a narrow (less than 5 eV wide) bump-like structure located 5 to 12 eV below the end point with integral intensity ∼ 7·10 -11 of the total decay rate. A specific feature of this structure proved to be a drift of the position of the bump during 3 years of measurement. No other visible anomalies in the measured part of the spectrum were found after introduction of a correction for an effect of electron trapping in the source. After accounting for the bump, the shape of the whole measured part of the beta spectrum agrees with zero mν2, thus eliminating the problem of “negative mν2”. The combined result of the 94 and 96 runs without the 97 run data is: m ν2=1.5±5.9 stat±3.6 syst{eV 2}/{C 4} From here most conservative limit for the neutrino mass is: m ν < 3.8 {eV}/{c 2} at 95 % C.L. A new type of differential spectrometer, based on adiabatisity principle is proposed.

ARE ULTRA-LONG GAMMA-RAY BURSTS CAUSED BY BLUE SUPERGIANT COLLAPSARS, NEWBORN MAGNETARS, OR WHITE DWARF TIDAL DISRUPTION EVENTS?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ioka, Kunihito; Hotokezaka, Kenta; Piran, Tsvi, E-mail: kunihito.ioka@yukawa.kyoto-u.ac.jp

Ultra-long gamma-ray bursts (ulGRBs) are a new population of GRBs with extreme durations of ∼10{sup 4} s. Leading candidates for their origin are blue supergiant collapsars, magnetars, and white dwarf tidal disruption events (WD-TDEs) caused by massive black holes (BHs). Recent observations of supernova-like (SN-like) bumps associated with ulGRBs challenged both the WD-TDE and the blue supergiant models because of the detection of SNe and the absence of hydrogen lines, respectively. We propose that WD-TDEs can accommodate the observed SN-like bumps if the fallback WD matter releases energy into the unbound WD ejecta. The observed ejecta energy, luminosity, and velocitymore » are explained by the gravitational energy, Eddington luminosity, and escape velocity of the formed accretion disk, respectively. We also show that the observed X-rays can ionize the ejecta, eliminating lines. The SN-like light curves (SN 2011kl) for the ulGRB 111209A are consistent with all three models, although a magnetar model is unnatural because the spin-down time required to power the SN-like bump is a hundred times longer than the GRB. Our results imply that TDEs are a possible energy source for SN-like events in general and for ulGRBs in particular.« less

Fluid aspects of electron streaming instability in electron-ion plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jao, C.-S.; Hau, L.-N.; Department of Physics, National Central University, Jhongli, Taiwan

2014-02-15

Electrons streaming in a background electron and ion plasma may lead to the formation of electrostatic solitary wave (ESW) and hole structure which have been observed in various space plasma environments. Past studies on the formation of ESW are mostly based on the particle simulations due to the necessity of incorporating particle's trapping effects. In this study, the fluid aspects and thermodynamics of streaming instabilities in electron-ion plasmas including bi-streaming and bump-on-tail instabilities are addressed based on the comparison between fluid theory and the results from particle-in-cell simulations. The energy closure adopted in the fluid model is the polytropic lawmore » of d(pρ{sup −γ})/dt=0 with γ being a free parameter. Two unstable modes are identified for the bump-on-tail instability and the growth rates as well as the dispersion relation of the streaming instabilities derived from the linear theory are found to be in good agreement with the particle simulations for both bi-streaming and bump-on-tail instabilities. At the nonlinear saturation, 70% of the electrons are trapped inside the potential well for the drift velocity being 20 times of the thermal velocity and the pρ{sup −γ} value is significantly increased. Effects of ion to electron mass ratio on the linear fluid theory and nonlinear simulations are also examined.« less

Spatial Convergence of Three Dimensional Turbulent Flows

NASA Technical Reports Server (NTRS)

Park, Michael A.; Anderson, W. Kyle

2016-01-01

Finite-volume and finite-element schemes, both implemented within the FUN3D flow solver, are evaluated for several test cases described on the Turbulence-Modeling Resource (TMR) web site. The cases include subsonic flow over a hemisphere cylinder, subsonic flow over a swept bump configuration, and supersonic flow in a square duct. The finite- volume and finite-element schemes are both used to obtain solutions for the first two cases, whereas only the finite-volume scheme is used for the supersonic duct. For the hemisphere cylinder, finite-element solutions obtained on tetrahedral meshes are compared with finite- volume solutions on mixed-element meshes. For the swept bump, finite-volume solutions have been obtained for both hexahedral and tetrahedral meshes and are compared with finite-element solutions obtained on tetrahedral meshes. For the hemisphere cylinder and the swept bump, solutions are obtained on a series of meshes with varying grid density and comparisons are made between drag coefficients, pressure distributions, velocity profiles, and profiles of the turbulence working variable. The square duct shows small variation due to element type or the spatial accuracy of turbulence model convection. It is demonstrated that the finite-element scheme on tetrahedral meshes yields similar accuracy as the finite- volume scheme on mixed-element and hexahedral grids, and demonstrates less sensitivity to the mesh topology (biased tetrahedral grids) than the finite-volume scheme.

Dynamics and afterglow light curves of gamma-ray burst blast waves encountering a density bump or void

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uhm, Z. Lucas; Zhang, Bing, E-mail: uhm@pku.edu.cn, E-mail: zhang@physics.unlv.edu

2014-07-01

We investigate the dynamics and afterglow light curves of gamma-ray burst blast waves that encounter various density structures (such as bumps, voids, or steps) in the surrounding ambient medium. We present and explain the characteristic response features that each type of density structure in the medium leaves on the forward shock (FS) and reverse shock (RS) dynamics for blast waves with either a long-lived or short-lived RS. We show that when the ambient medium density drops, the blast waves exhibit in some cases a period of an actual acceleration (even during their deceleration stage) due to adiabatic cooling of blastmore » waves. Comparing numerical examples that have different shapes of bumps or voids, we propose a number of consistency tests that must be satisfied by correct modeling of blast waves. Our model results successfully pass these tests. Employing a Lagrangian description of blast waves, we perform a sophisticated calculation of afterglow emission. We show that as a response to density structures in the ambient medium, the RS light curves produce more significant variations than the FS light curves. Some observed features (such as rebrightenings, dips, or slow wiggles) can be more easily explained within the RS model. We also discuss the origin of these different features imprinted on the FS and RS light curves.« less

Effects of structural and chemical disorders on the vis/UV spectra of carbonaceous interstellar grains

NASA Astrophysics Data System (ADS)

Papoular, Robert J.; Yuan, Shengjun; Roldán, Rafael; Katsnelson, Mikhail I.; Papoular, Renaud

2013-07-01

The recent spectacular progress in the experimental and theoretical understanding of graphene, the basic constituent of graphite, is applied here to compute, from first principles, the ultraviolet extinction of nanoparticles made of stacks of graphene layers. The theory also covers cases where graphene is affected by structural, chemical or orientation disorder, each disorder type being quantitatively defined by a single parameter. The extinction bumps carried by such model materials are found to have positions and widths falling in the same range as the known astronomical 2175 Å features: as the disorder parameter increases, the bump width increases from 0.85 to 2.5 μm-1, while its peak position shifts from 4.65 to 4.75 μm-1. Moderate degrees of disorder are enough to cover the range of widths of the vast majority of observed bumps (0.75 to 1.3 μm-1). Higher degrees account for outliers, also observed in the sky. The introduction of structural or chemical disorder amounts to changing the initial sp2 bondings into sp3 or sp1, so the optical properties of the model material become similar to those of the more or less amorphous carbon-rich materials studied in the laboratory: a-C, a-C:H, HAC, ACH, coals, etc. The present treatment thus bridges gaps between physically different model materials.

The role of visuohaptic experience in visually perceived depth.

PubMed

Ho, Yun-Xian; Serwe, Sascha; Trommershäuser, Julia; Maloney, Laurence T; Landy, Michael S

2009-06-01

Berkeley suggested that "touch educates vision," that is, haptic input may be used to calibrate visual cues to improve visual estimation of properties of the world. Here, we test whether haptic input may be used to "miseducate" vision, causing observers to rely more heavily on misleading visual cues. Human subjects compared the depth of two cylindrical bumps illuminated by light sources located at different positions relative to the surface. As in previous work using judgments of surface roughness, we find that observers judge bumps to have greater depth when the light source is located eccentric to the surface normal (i.e., when shadows are more salient). Following several sessions of visual judgments of depth, subjects then underwent visuohaptic training in which haptic feedback was artificially correlated with the "pseudocue" of shadow size and artificially decorrelated with disparity and texture. Although there were large individual differences, almost all observers demonstrated integration of haptic cues during visuohaptic training. For some observers, subsequent visual judgments of bump depth were unaffected by the training. However, for 5 of 12 observers, training significantly increased the weight given to pseudocues, causing subsequent visual estimates of shape to be less veridical. We conclude that haptic information can be used to reweight visual cues, putting more weight on misleading pseudocues, even when more trustworthy visual cues are available in the scene.

Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography

NASA Astrophysics Data System (ADS)

Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

2015-04-01

We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). In this paper, we propose a method for extraction of the specific eccrine sweat gland by means of the connected component extraction process and the adaptive threshold method, where the en face OCT images are constructed by the swept-source OCT. In the experiment, we demonstrate precise measurement of the volume of the sweat gland in response to the external stimulus.

Precise calibration of pupil images in pyramid wavefront sensor.

PubMed

Liu, Yong; Mu, Quanquan; Cao, Zhaoliang; Hu, Lifa; Yang, Chengliang; Xuan, Li

2017-04-20

The pyramid wavefront sensor (PWFS) is a novel wavefront sensor with several inspiring advantages compared with Shack-Hartmann wavefront sensors. The PWFS uses four pupil images to calculate the local tilt of the incoming wavefront. Pupil images are conjugated with a telescope pupil so that each pixel in the pupil image is diffraction-limited by the telescope pupil diameter, thus the sensing error of the PWFS is much lower than that of the Shack-Hartmann sensor and is related to the extraction and alignment accuracy of pupil images. However, precise extraction of these images is difficult to conduct in practice. Aiming at improving the sensing accuracy, we analyzed the physical model of calibration of a PWFS and put forward an extraction algorithm. The process was verified via a closed-loop correction experiment. The results showed that the sensing accuracy of the PWFS increased after applying the calibration and extraction method.

Comparison of four extraction/methylation analytical methods to measure fatty acid composition by gas chromatography in meat.

PubMed

Juárez, M; Polvillo, O; Contò, M; Ficco, A; Ballico, S; Failla, S

2008-05-09

Four different extraction-derivatization methods commonly used for fatty acid analysis in meat (in situ or one-step method, saponification method, classic method and a combination of classic extraction and saponification derivatization) were tested. The in situ method had low recovery and variation. The saponification method showed the best balance between recovery, precision, repeatability and reproducibility. The classic method had high recovery and acceptable variation values, except for the polyunsaturated fatty acids, showing higher variation than the former methods. The combination of extraction and methylation steps had great recovery values, but the precision, repeatability and reproducibility were not acceptable. Therefore the saponification method would be more convenient for polyunsaturated fatty acid analysis, whereas the in situ method would be an alternative for fast analysis. However the classic method would be the method of choice for the determination of the different lipid classes.

Using Mobile Laser Scanning Data for Features Extraction of High Accuracy Driving Maps

NASA Astrophysics Data System (ADS)

Yang, Bisheng; Liu, Yuan; Liang, Fuxun; Dong, Zhen

2016-06-01

High Accuracy Driving Maps (HADMs) are the core component of Intelligent Drive Assistant Systems (IDAS), which can effectively reduce the traffic accidents due to human error and provide more comfortable driving experiences. Vehicle-based mobile laser scanning (MLS) systems provide an efficient solution to rapidly capture three-dimensional (3D) point clouds of road environments with high flexibility and precision. This paper proposes a novel method to extract road features (e.g., road surfaces, road boundaries, road markings, buildings, guardrails, street lamps, traffic signs, roadside-trees, power lines, vehicles and so on) for HADMs in highway environment. Quantitative evaluations show that the proposed algorithm attains an average precision and recall in terms of 90.6% and 91.2% in extracting road features. Results demonstrate the efficiencies and feasibilities of the proposed method for extraction of road features for HADMs.

Optics measurement and correction for the Relativistic Heavy Ion Collider

NASA Astrophysics Data System (ADS)

Shen, Xiaozhe

The quality of beam optics is of great importance for the performance of a high energy accelerator like the Relativistic Heavy Ion Collider (RHIC). The turn-by-turn (TBT) beam position monitor (BPM) data can be used to derive beam optics. However, the accuracy of the derived beam optics is often limited by the performance and imperfections of instruments as well as measurement methods and conditions. Therefore, a robust and model-independent data analysis method is highly desired to extract noise-free information from TBT BPM data. As a robust signal-processing technique, an independent component analysis (ICA) algorithm called second order blind identification (SOBI) has been proven to be particularly efficient in extracting physical beam signals from TBT BPM data even in the presence of instrument's noise and error. We applied the SOBI ICA algorithm to RHIC during the 2013 polarized proton operation to extract accurate linear optics from TBT BPM data of AC dipole driven coherent beam oscillation. From the same data, a first systematic estimation of RHIC BPM noise performance was also obtained by the SOBI ICA algorithm, and showed a good agreement with the RHIC BPM configurations. Based on the accurate linear optics measurement, a beta-beat response matrix correction method and a scheme of using horizontal closed orbit bumps at sextupoles for arc beta-beat correction were successfully applied to reach a record-low beam optics error at RHIC. This thesis presents principles of the SOBI ICA algorithm and theory as well as experimental results of optics measurement and correction at RHIC.

Hives (Urticaria)

MedlinePlus

... look like tiny little spots, blotches, or large connected bumps. Individual hives can last anywhere from a ... cold or place a sandbag or other heavy object on your thighs to see if the pressure ...

7 CFR 51.3154 - Well formed.

Code of Federal Regulations, 2010 CFR

2010-01-01

... FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) United States... has the shape characteristic of the variety and that bumps or other roughness do not materially...

Genital Warts

MedlinePlus

... transmitted disease (STD) caused by the human papillomavirus (HPV). The warts usually appear as a small bump ... completely eliminate, the risk of catching or spreading HPV. The most reliable way to avoid infection is ...

Bidirectional reflection functions from surface bump maps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabral, B.; Max, N.; Springmeyer, R.

1987-04-29

The Torrance-Sparrow model for calculating bidirectional reflection functions contains a geometrical attenuation factor to account for shadowing and occlusions in a hypothetical distribution of grooves on a rough surface. Using an efficient table-based method for determining the shadows and occlusions, we calculate the geometric attenuation factor for surfaces defined by a specific table of bump heights. Diffuse and glossy specular reflection of the environment can be handled in a unified manner by using an integral of the bidirectional reflection function times the environmental illumination, over the hemisphere of solid angle above a surface. We present a method of estimating themore » integral, by expanding the bidirectional reflection coefficient in spherical harmonics, and show how the coefficients in this expansion can be determined efficiently by reorganizing our geometric attenuation calculation.« less

Cruise tap versus handshake: using common sense to reduce hand contamination and germ transmission on cruise ships.

PubMed

Dahl, Eilif

2016-01-01

A firm handshake is a widely used greeting, but contaminated fingers and palms can also transfer bacteria and virus. Hand sanitation is important to prevent spreading of contagious diseases, but to wash hands properly takes too much time to ensure satisfactory compliance. Banning the handshake from health care settings has been proposed, but an alternative, less contagious form of greeting must be substituted. Cruise ships are particular vulnerable to infectious diseases that are transferred from person to person. The fist bump, common in some subcultures, has become increasing popular as the greeting-of-choice on smaller cruise vessels. To further reduce the contact area, a modification of the fist bump, the 'cruise tap', where only two knuckles briefly touch each other, is recommended.

Improved Reliability of SiC Pressure Sensors for Long Term High Temperature Applications

NASA Technical Reports Server (NTRS)

Okojie, R. S.; Nguyen, V.; Savrun, E.; Lukco, D.

2011-01-01

We report advancement in the reliability of silicon carbide pressure sensors operating at 600 C for extended periods. The large temporal drifts in zero pressure offset voltage at 600 C observed previously were significantly suppressed to allow improved reliable operation. This improvement was the result of further enhancement of the electrical and mechanical integrity of the bondpad/contact metallization, and the introduction of studded bump bonding on the pad. The stud bump contact promoted strong adhesion between the Au bond pad and the Au die-attach. The changes in the zero offset voltage and bridge resistance over time at temperature were explained by the microstructure and phase changes within the contact metallization, that were analyzed with Auger electron spectroscopy (AES) and field emission scanning electron microscopy (FE-SEM).

Expressions for the spherical-wave-structure function based on a bump spectrum model for the index of refraction

NASA Astrophysics Data System (ADS)

Richardson, Christina E.; Andrews, Larry C.

1991-07-01

New spectra models have recently been developed for the spatial power spectra of temperature and refractive index fluctuations in the atmospheric boundary layer showing the characteristic 'bump' just prior to the dissipation ranges. Theoretical work involving these new models has led to new expressions for the phase structure function associated with a plane optical wave, although most experimental work has involved spherical waves. Following techniques similar to those used for the plane wave analysis, new expressions valid in geometrical and diffraction regimes are developed here for the phase structure function of a spherical optical wave propagating through clear-air atmospheric turbulence. Useful asymptotic formulas for small separation distances and the inertial subrange are derived from these general expressions.

A review on solder reflow and flux application for flip chip

NASA Astrophysics Data System (ADS)

Suppiah, Sarveshvaran; Ong, Nestor Rubio; Sauli, Zaliman; Sarukunaselan, Karunavani; Alcain, Jesselyn Barro; Visvanathan, Susthitha Menon; Retnasamy, Vithyacharan

2017-09-01

This paper encompassed of the evolution and key findings, critical technical challenges, solutions and bonding equipment of solder reflow in flip chip bonding. Upon scrutinizing researches done by others, it can be deduced that peak temperature, time above liquidus, soak temperature, soak time, cooling rate and reflow environment played a vital role in achieving the desired bonding profile. In addition, flux is also needed with the purpose of removing oxides/contaminations on bump surface as well as to promote wetting of solder balls. Electromigration and warpage are the two main challenges faced by solder reflow process which can be overcome by the advancement in under bump metallization (UBM) and substrate technology. The review is ended with a brief description of the current equipment used in solder reflow process.

The bumpy light curve of Type IIn supernova iPTF13z over 3 years

NASA Astrophysics Data System (ADS)

Nyholm, A.; Sollerman, J.; Taddia, F.; Fremling, C.; Moriya, T. J.; Ofek, E. O.; Gal-Yam, A.; De Cia, A.; Roy, R.; Kasliwal, M. M.; Cao, Y.; Nugent, P. E.; Masci, F. J.

2017-08-01

A core-collapse (CC) supernova (SN) of Type IIn is dominated by the interaction of SN ejecta with the circumstellar medium (CSM). Some SNe IIn (e.g. SN 2006jd) have episodes of re-brightening ("bumps") in their light curves. We present iPTF13z, a Type IIn SN discovered on 2013 February 1 by the intermediate Palomar Transient Factory (iPTF). This SN showed at least five bumps in its declining light curve between 130 and 750 days after discovery. We analyse this peculiar behaviour and try to infer the properties of the CSM, of the SN explosion, and the nature of the progenitor star. We obtained multi-band optical photometry for over 1000 days after discovery with the P48 and P60 telescopes at Palomar Observatory. We obtained low-resolution optical spectra during the same period. We did an archival search for progenitor outbursts. We analyse the photometry and the spectra, and compare iPTF13z to other SNe IIn. In particular we derive absolute magnitudes, colours, a pseudo-bolometric light curve, and the velocities of the different components of the spectral lines. A simple analytical model is used to estimate the properties of the CSM. iPTF13z had a light curve peaking at Mr ≲ - 18.3 mag. The five bumps during its decline phase had amplitudes ranging from 0.4 to 0.9 mag and durations between 20 and 120 days. The most prominent bumps appeared in all the different optical bands, when covered. The spectra of this SN showed typical SN IIn characteristics, with emission lines of Hα (with broad component FWHM 103 - 104 km s-1 and narrow component FWHM 102 km s-1) and He I, but also with Fe II, Ca II, Na I D and Hβ P Cygni profiles (with velocities of 103km s-1). A pre-explosion outburst was identified lasting ≳ 50 days, with Mr ≈ - 15 mag around 210 days before discovery. Large, variable progenitor mass-loss rates (≳0.01M⊙ yr-1) and CSM densities (≳10-16 g cm-3) are derived. The SN was hosted by a metal-poor dwarf galaxy at redshift z = 0.0328. We suggest that the light curve bumps of iPTF13z arose from SN ejecta interacting with denser regions in the CSM, possibly produced by the eruptions of a luminous blue variable progenitor star. Full Tables A.2, A.3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/605/A6

Simultaneous Determination of Crypto-Chlorogenic Acid, Isoquercetin, and Astragalin Contents in Moringa oleifera Leaf Extracts by TLC-Densitometric Method.

PubMed

Vongsak, Boonyadist; Sithisarn, Pongtip; Gritsanapan, Wandee

2013-01-01

Moringa oleifera Lamarck (Moringaceae) is used as a multipurpose medicinal plant for the treatment of various diseases. Isoquercetin, astragalin, and crypto-chlorogenic acid have been previously found to be major active components in the leaves of this plant. In this study, a thin-layer-chromatography (TLC-)densitometric method was developed and validated for simultaneous quantification of these major components in the 70% ethanolic extracts of M. oleifera leaves collected from 12 locations. The average amounts of crypto-chlorogenic acid, isoquercetin, and astragalin were found to be 0.0473, 0.0427, and 0.0534% dry weight, respectively. The method was validated for linearity, precision, accuracy, limit of detection, limit of quantitation, and robustness. The linearity was obtained in the range of 100-500 ng/spot with a correlation coefficient (r) over 0.9961. Intraday and interday precisions demonstrated relative standard deviations of less than 5%. The accuracy of the method was confirmed by determining the recovery. The average recoveries of each component from the extracts were in the range of 98.28 to 99.65%. Additionally, the leaves from Chiang Mai province contained the highest amounts of all active components. The proposed TLC-densitometric method was simple, accurate, precise, and cost-effective for routine quality controlling of M. oleifera leaf extracts.

Total Flavonoids Content in the Raw Material and Aqueous Extractives from Bauhinia monandra Kurz (Caesalpiniaceae)

PubMed Central

Fernandes, Ana Josane Dantas; Ferreira, Magda Rhayanny Assunção; Randau, Karina Perrelli; de Souza, Tatiane Pereira; Soares, Luiz Alberto Lira

2012-01-01

The aim of this work was to evaluate the spectrophotometric methodology for determining the total flavonoid content (TFC) in herbal drug and derived products from Bauhinia monandra Kurz. Several analytical parameters from this method grounded on the complex formed between flavonoids and AlCl3 were evaluated such as herbal amount (0.25 to 1.25 g); solvent composition (ethanol 40 to 80%, v/v); as well as the reaction time and AlCl3 concentration (2 to 9%, w/v). The method was adjusted to aqueous extractives and its performance studied through precision, linearity and preliminary robustness. The results showed an important dependence of the method response from reaction time, AlCl3 concentration, sample amount, and solvent mixture. After choosing the optimized condition, the method was applied for the matrixes (herbal material and extractives), showing precision lower than 5% (for both parameters repeatability and intermediate precision), coefficient of determination higher than 0.99, and no important influence could be observed for slight variations from wavelength or AlCl3 concentration. Thus, it could be concluded that the evaluated analytical procedure was suitable to quantify the total flavonoid content in raw material and aqueous extractives from leaves of B. monandra. PMID:22701375

Hives (Urticaria) (For Parents)

MedlinePlus

... look like tiny little spots, blotches, or large connected bumps. Individual hives can last anywhere from a ... cold or place a sandbag or other heavy object on the thighs to see if the pressure ...

Babies and heat rashes

MedlinePlus

... occurs in babies when the pores of the sweat glands become blocked. This happens most often when ... weather is hot or humid. As your infant sweats, little red bumps, and possibly tiny blisters, form ...

Effects of ice shelf basal melt variability on evolution of Thwaites Glacier

NASA Astrophysics Data System (ADS)

Hoffman, M. J.; Fyke, J. G.; Price, S. F.; Asay-Davis, X.; Perego, M.

2017-12-01

Theory, modeling, and observations indicate that marine ice sheets on a retrograde bed, including Thwaites Glacier, Antarctica, are only conditionally stable. Previous modeling studies have shown that rapid, unstable retreat can occur when steady ice-shelf basal melting causes the grounding line to retreat past restraining bedrock bumps. Here we explore the initiation and evolution of unstable retreat of Thwaites Glacier when the ice-shelf basal melt forcing includes temporal variability mimicking realistic climate variability. We use the three-dimensional, higher-order Model for Prediction Across Scales-Land Ice (MPASLI) model forced with an ice shelf basal melt parameterization derived from previous coupled ice sheet/ocean simulations. We add sinusoidal temporal variability to the melt parameterization that represents shoaling and deepening of Circumpolar Deep Water. We perform an ensemble of 250 year duration simulations with different values for the amplitude, period, and phase of the variability. Preliminary results suggest that, overall, variability leads to slower grounding line retreat and less mass loss than steady simulations. Short period (2 yr) variability leads to similar results as steady forcing, whereas decadal variability can result in up to one-third less mass loss. Differences in phase lead to a large range in mass loss/grounding line retreat, but it is always less than the steady forcing. The timing of ungrounding from each restraining bedrock bump, which is strongly affected by the melt variability, is the rate limiting factor, and variability-driven delays in ungrounding at each bump accumulate. Grounding line retreat in the regions between bedrock bumps is relatively unaffected by ice shelf melt variability. While the results are sensitive to the form of the melt parameterization and its variability, we conclude that decadal period ice shelf melt variability could potentially delay marine ice sheet instability by up to many decades. However, it does not alter the eventual mass loss and sea level rise at centennial scales. The potential differences are significant enough to highlight the need for further observations to constrain the amplitude and period of the modes of climate and ocean variability relevant to Antarctic ice shelf melting.

Blood pressure self-monitoring in pregnancy (BuMP) feasibility study; a qualitative analysis of women's experiences of self-monitoring.

PubMed

Hinton, Lisa; Tucker, Katherine L; Greenfield, Sheila M; Hodgkinson, James A; Mackillop, Lucy; McCourt, Christine; Carver, Trisha; Crawford, Carole; Glogowska, Margaret; Locock, Louise; Selwood, Mary; Taylor, Kathryn S; McManus, Richard J

2017-12-19

Hypertensive disorders in pregnancy are a leading cause of maternal and fetal morbidity worldwide. Raised blood pressure (BP) affects 10% of pregnancies worldwide, of which almost half develop pre-eclampsia. The proportion of pregnant women who have risk factors for pre-eclampsia (such as pre-existing hypertension, obesity and advanced maternal age) is increasing. Pre-eclampsia can manifest itself before women experience symptoms and can develop between antenatal visits. Incentives to improve early detection of gestational hypertensive disorders are therefore strong and self-monitoring of blood pressure (SMBP) in pregnancy might be one means to achieve this, whilst improving women's involvement in antenatal care. The Blood Pressure Self-Monitoring in Pregnancy (BuMP) study aimed to evaluate the feasibility and acceptability of SMBP in pregnancy. To understand women's experiences of SMBP during pregnancy, we undertook a qualitative study embedded within the BuMP observational feasibility study. Women who were at higher risk of developing hypertension and/or pre-eclampsia were invited to take part in a study using SMBP and also invited to take part in an interview. Semi-structured interviews were conducted at the women's homes in Oxfordshire and Birmingham with women who were self-monitoring their BP as part of the BuMP feasibility study in 2014. Interviews were conducted by a qualitative researcher and transcribed verbatim. A framework approach was used for analysis. Fifteen women agreed to be interviewed. Respondents reported general willingness to engage with monitoring their own BP, feeling that it could reduce anxiety around their health during pregnancy, particularly if they had previous experience of raised BP or pre-eclampsia. They felt able to incorporate self-monitoring into their weekly routines, although this was harder post-partum. Self-monitoring of BP made them more aware of the risks of hypertension and pre-eclampsia in pregnancy. Feelings of reassurance and empowerment were commonly reported by the women in our sample. SMBP in pregnancy was both acceptable and feasible to women in this small pilot study.

Automated concept-level information extraction to reduce the need for custom software and rules development.

PubMed

D'Avolio, Leonard W; Nguyen, Thien M; Goryachev, Sergey; Fiore, Louis D

2011-01-01

Despite at least 40 years of promising empirical performance, very few clinical natural language processing (NLP) or information extraction systems currently contribute to medical science or care. The authors address this gap by reducing the need for custom software and rules development with a graphical user interface-driven, highly generalizable approach to concept-level retrieval. A 'learn by example' approach combines features derived from open-source NLP pipelines with open-source machine learning classifiers to automatically and iteratively evaluate top-performing configurations. The Fourth i2b2/VA Shared Task Challenge's concept extraction task provided the data sets and metrics used to evaluate performance. Top F-measure scores for each of the tasks were medical problems (0.83), treatments (0.82), and tests (0.83). Recall lagged precision in all experiments. Precision was near or above 0.90 in all tasks. Discussion With no customization for the tasks and less than 5 min of end-user time to configure and launch each experiment, the average F-measure was 0.83, one point behind the mean F-measure of the 22 entrants in the competition. Strong precision scores indicate the potential of applying the approach for more specific clinical information extraction tasks. There was not one best configuration, supporting an iterative approach to model creation. Acceptable levels of performance can be achieved using fully automated and generalizable approaches to concept-level information extraction. The described implementation and related documentation is available for download.

Determination of Total Biotin by Liquid Chromatography Coupled with Immunoaffinity Column Cleanup Extraction: Multilaboratory Testing, Final Action 2016.02.

PubMed

Joseph, George; Devi, Ranjani; Marley, Elaine C; Leeman, David

2018-05-01

Single- and multilaboratory testing data have provided systematic scientific evidence that a simple, selective, accurate, and precise method can be used as a potential candidate reference method for dispute resolution in determining total biotin in all forms of infant, adult, and/or pediatric formula. Using LC coupled with immunoaffinity column cleanup extraction, the method fully meets the intended purpose and applicability statement in AOAC Standard Method Performance Requirement 2014.005. The method was applied to a cross-section of infant formula and adult nutritional matrixes, and acceptable precision and accuracy were established. The analytical platform is inexpensive, and the method can be used in almost any laboratory worldwide with basic facilities. The immunoaffinity column cleanup extraction is the key step to successful analysis.

Quantitative assessment of tumour extraction from dermoscopy images and evaluation of computer-based extraction methods for an automatic melanoma diagnostic system.

PubMed

Iyatomi, Hitoshi; Oka, Hiroshi; Saito, Masataka; Miyake, Ayako; Kimoto, Masayuki; Yamagami, Jun; Kobayashi, Seiichiro; Tanikawa, Akiko; Hagiwara, Masafumi; Ogawa, Koichi; Argenziano, Giuseppe; Soyer, H Peter; Tanaka, Masaru

2006-04-01

The aims of this study were to provide a quantitative assessment of the tumour area extracted by dermatologists and to evaluate computer-based methods from dermoscopy images for refining a computer-based melanoma diagnostic system. Dermoscopic images of 188 Clark naevi, 56 Reed naevi and 75 melanomas were examined. Five dermatologists manually drew the border of each lesion with a tablet computer. The inter-observer variability was evaluated and the standard tumour area (STA) for each dermoscopy image was defined. Manual extractions by 10 non-medical individuals and by two computer-based methods were evaluated with STA-based assessment criteria: precision and recall. Our new computer-based method introduced the region-growing approach in order to yield results close to those obtained by dermatologists. The effectiveness of our extraction method with regard to diagnostic accuracy was evaluated. Two linear classifiers were built using the results of conventional and new computer-based tumour area extraction methods. The final diagnostic accuracy was evaluated by drawing the receiver operating curve (ROC) of each classifier, and the area under each ROC was evaluated. The standard deviations of the tumour area extracted by five dermatologists and 10 non-medical individuals were 8.9% and 10.7%, respectively. After assessment of the extraction results by dermatologists, the STA was defined as the area that was selected by more than two dermatologists. Dermatologists selected the melanoma area with statistically smaller divergence than that of Clark naevus or Reed naevus (P = 0.05). By contrast, non-medical individuals did not show this difference. Our new computer-based extraction algorithm showed superior performance (precision, 94.1%; recall, 95.3%) to the conventional thresholding method (precision, 99.5%; recall, 87.6%). These results indicate that our new algorithm extracted a tumour area close to that obtained by dermatologists and, in particular, the border part of the tumour was adequately extracted. With this refinement, the area under the ROC increased from 0.795 to 0.875 and the diagnostic accuracy showed an increase of approximately 20% in specificity when the sensitivity was 80%. It can be concluded that our computer-based tumour extraction algorithm extracted almost the same area as that obtained by dermatologists and provided improved computer-based diagnostic accuracy.

Fine-grained information extraction from German transthoracic echocardiography reports.

PubMed

Toepfer, Martin; Corovic, Hamo; Fette, Georg; Klügl, Peter; Störk, Stefan; Puppe, Frank

2015-11-12

Information extraction techniques that get structured representations out of unstructured data make a large amount of clinically relevant information about patients accessible for semantic applications. These methods typically rely on standardized terminologies that guide this process. Many languages and clinical domains, however, lack appropriate resources and tools, as well as evaluations of their applications, especially if detailed conceptualizations of the domain are required. For instance, German transthoracic echocardiography reports have not been targeted sufficiently before, despite of their importance for clinical trials. This work therefore aimed at development and evaluation of an information extraction component with a fine-grained terminology that enables to recognize almost all relevant information stated in German transthoracic echocardiography reports at the University Hospital of Würzburg. A domain expert validated and iteratively refined an automatically inferred base terminology. The terminology was used by an ontology-driven information extraction system that outputs attribute value pairs. The final component has been mapped to the central elements of a standardized terminology, and it has been evaluated according to documents with different layouts. The final system achieved state-of-the-art precision (micro average.996) and recall (micro average.961) on 100 test documents that represent more than 90 % of all reports. In particular, principal aspects as defined in a standardized external terminology were recognized with f 1=.989 (micro average) and f 1=.963 (macro average). As a result of keyword matching and restraint concept extraction, the system obtained high precision also on unstructured or exceptionally short documents, and documents with uncommon layout. The developed terminology and the proposed information extraction system allow to extract fine-grained information from German semi-structured transthoracic echocardiography reports with very high precision and high recall on the majority of documents at the University Hospital of Würzburg. Extracted results populate a clinical data warehouse which supports clinical research.

A subtle calculation method for nanoparticle’s molar extinction coefficient: The gift from discrete protein-nanoparticle system on agarose gel electrophoresis

NASA Astrophysics Data System (ADS)

Zhong, Ruibo; Yuan, Ming; Gao, Haiyang; Bai, Zhijun; Guo, Jun; Zhao, Xinmin; Zhang, Feng

2016-03-01

Discrete biomolecule-nanoparticle (NP) conjugates play paramount roles in nanofabrication, in which the key is to get the precise molar extinction coefficient of NPs. By making best use of the gift from a specific separation phenomenon of agarose gel electrophoresis (GE), amphiphilic polymer coated NP with exact number of bovine serum albumin (BSA) proteins can be extracted and further experimentally employed to precisely calculate the molar extinction coefficient of the NPs. This method could further benefit the evaluation and extraction of any other dual-component NP-containing bio-conjugates.

Extraction efficiency and implications for absolute quantitation of propranolol in mouse brain, liver and kidney thin tissue sections using droplet-based liquid microjunction surface sampling-HPLC ESI-MS/MS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kertesz, Vilmos; Weiskittel, Taylor M.; Vavek, Marissa

Currently, absolute quantitation aspects of droplet-based surface sampling for thin tissue analysis using a fully automated autosampler/HPLC-ESI-MS/MS system are not fully evaluated. Knowledge of extraction efficiency and its reproducibility is required to judge the potential of the method for absolute quantitation of analytes from thin tissue sections. Methods: Adjacent thin tissue sections of propranolol dosed mouse brain (10- μm-thick), kidney (10- μm-thick) and liver (8-, 10-, 16- and 24- μm-thick) were obtained. Absolute concentration of propranolol was determined in tissue punches from serial sections using standard bulk tissue extraction protocols and subsequent HPLC separations and tandem mass spectrometric analysis. Thesemore » values were used to determine propranolol extraction efficiency from the tissues with the droplet-based surface sampling approach. Results: Extraction efficiency of propranolol using 10- μm-thick brain, kidney and liver thin tissues using droplet-based surface sampling varied between ~45-63%. Extraction efficiency decreased from ~65% to ~36% with liver thickness increasing from 8 μm to 24 μm. Randomly selecting half of the samples as standards, precision and accuracy of propranolol concentrations obtained for the other half of samples as quality control metrics were determined. Resulting precision ( ±15%) and accuracy ( ±3%) values, respectively, were within acceptable limits. In conclusion, comparative quantitation of adjacent mouse thin tissue sections of different organs and of various thicknesses by droplet-based surface sampling and by bulk extraction of tissue punches showed that extraction efficiency was incomplete using the former method, and that it depended on the organ and tissue thickness. However, once extraction efficiency was determined and applied, the droplet-based approach provided the required quantitation accuracy and precision for assay validations. Furthermore, this means that once the extraction efficiency was calibrated for a given tissue type and drug, the droplet-based approach provides a non-labor intensive and high-throughput means to acquire spatially resolved quantitative analysis of multiple samples of the same type.« less

Extraction efficiency and implications for absolute quantitation of propranolol in mouse brain, liver and kidney thin tissue sections using droplet-based liquid microjunction surface sampling-HPLC ESI-MS/MS

DOE PAGES

Kertesz, Vilmos; Weiskittel, Taylor M.; Vavek, Marissa; ...

2016-06-22

Currently, absolute quantitation aspects of droplet-based surface sampling for thin tissue analysis using a fully automated autosampler/HPLC-ESI-MS/MS system are not fully evaluated. Knowledge of extraction efficiency and its reproducibility is required to judge the potential of the method for absolute quantitation of analytes from thin tissue sections. Methods: Adjacent thin tissue sections of propranolol dosed mouse brain (10- μm-thick), kidney (10- μm-thick) and liver (8-, 10-, 16- and 24- μm-thick) were obtained. Absolute concentration of propranolol was determined in tissue punches from serial sections using standard bulk tissue extraction protocols and subsequent HPLC separations and tandem mass spectrometric analysis. Thesemore » values were used to determine propranolol extraction efficiency from the tissues with the droplet-based surface sampling approach. Results: Extraction efficiency of propranolol using 10- μm-thick brain, kidney and liver thin tissues using droplet-based surface sampling varied between ~45-63%. Extraction efficiency decreased from ~65% to ~36% with liver thickness increasing from 8 μm to 24 μm. Randomly selecting half of the samples as standards, precision and accuracy of propranolol concentrations obtained for the other half of samples as quality control metrics were determined. Resulting precision ( ±15%) and accuracy ( ±3%) values, respectively, were within acceptable limits. In conclusion, comparative quantitation of adjacent mouse thin tissue sections of different organs and of various thicknesses by droplet-based surface sampling and by bulk extraction of tissue punches showed that extraction efficiency was incomplete using the former method, and that it depended on the organ and tissue thickness. However, once extraction efficiency was determined and applied, the droplet-based approach provided the required quantitation accuracy and precision for assay validations. Furthermore, this means that once the extraction efficiency was calibrated for a given tissue type and drug, the droplet-based approach provides a non-labor intensive and high-throughput means to acquire spatially resolved quantitative analysis of multiple samples of the same type.« less

Determination of ketamine and its main metabolites by liquid chromatography coupled to tandem mass spectrometry in pig plasma: Comparison of extraction methods.

PubMed

Ramiole, Cindy; D'Hayer, Benoit; Boudy, Vincent; Legagneux, Josette; Fonsart, Julien; Houzé, Pascal

2017-11-30

A rapid, sensitive and specific liquid chromatography coupled to tandem mass spectrometry method was developed for the simultaneous quantification pig plasma of ketamine and its two principal metabolites, norketamine and dehydronorketamine. Three extraction procoles were assessed including acetonitrile precipitation, Oase™ microplate extraction, and liquid-liquid extraction. Oase™ microplate extraction induced no significant matrix effect, important signal/noise ratio and good recoveries, ranging from 82 to 87% for the considered compounds. Using this extraction procedure, the assay was linear in the dynamic range 10-3000ng/mL (R 2 >0.99) regardless of the analytes. Intra- and inter-day accuracies were less than 12% for all compounds and intra- and inter-day precisions expressed as RSD were within <9.9%. Samples were stable in different storage conditions. High ketamine, norketamine and dehydronorketamine concentrations up to 15,000ng/mL can be determined with good precision using appropriate sample dilution. The assay was successfully applied to pig plasma samples to determine the pharmacokinetics of ketamine and the consecutive metabolites after buccal administration of a 4mg/kg ketamine base solutions. Copyright © 2017 Elsevier B.V. All rights reserved.

Cognition-Based Approaches for High-Precision Text Mining

ERIC Educational Resources Information Center

Shannon, George John

2017-01-01

This research improves the precision of information extraction from free-form text via the use of cognitive-based approaches to natural language processing (NLP). Cognitive-based approaches are an important, and relatively new, area of research in NLP and search, as well as linguistics. Cognitive approaches enable significant improvements in both…

Traumatic Brain Injury (TBI) in Kids

MedlinePlus

... Information Share Facebook Twitter Pinterest Email Print Traumatic Brain Injury (TBI): Condition Information What is TBI? TBI ... external force that affects the functioning of the brain. It can be caused by a bump or ...

Poison Ivy/Oak/Sumac

MedlinePlus

... burning, or blistering. Severe, widespread rashes require medical treatment. Signs and Symptoms an itchy red rash that appears within 4 hours to 4 days after touching the plant oil blisters that ooze clear fluid bumps and ...

Traumatic Brain Injury

MedlinePlus

Traumatic brain injury (TBI) happens when a bump, blow, jolt, or other head injury causes damage to the brain. Every year, millions of people in the U.S. suffer brain injuries. More than half are bad enough that ...

Microfabricated Electrical Connector for Atomic Force Microscopy Probes with Integrated Sensor/Actuator

NASA Astrophysics Data System (ADS)

Akiyama, Terunobu; Staufer, Urs; Rooij, Nico F. de

2002-06-01

A microfabricated, electrical connector is proposed for facilitating the mounting of atomic force microscopy (AFM) probes, which have an integrated sensor and/or actuator. Only a base chip, which acts as a socket, is permanently fixed onto a printed circuit board and electronically connected by standard wire bonding. The AFM chip, the “plug”, is flipped onto the base chip and pressed from the backside by a spring. Electrical contact with the eventual stress sensors, capacitive or piezoelectric sensor/actuators, is provided by contact bumps. These bumps of about 8 μm height are placed onto the base chip. They touch the pads on the AFM chip that were originally foreseen to be for wire bonding and thus provide the electrical contact. This connector schema was successfully used to register AFM images with piezoresistive cantilevers.

Detonative propagation and accelerative expansion of the Crab Nebula shock front.

PubMed

Gao, Yang; Law, Chung K

2011-10-21

The accelerative expansion of the Crab Nebula's outer envelope is a mystery in dynamics, as a conventional expanding blast wave decelerates when bumping into the surrounding interstellar medium. Here we show that the strong relativistic pulsar wind bumping into its surrounding nebula induces energy-generating processes and initiates a detonation wave that propagates outward to form the current outer edge, namely, the shock front, of the nebula. The resulting detonation wave, with a reactive downstream, then provides the needed power to maintain propagation of the shock front. Furthermore, relaxation of the curvature-induced reduction of the propagation velocity from the initial state of formation to the asymptotic, planar state of Chapman-Jouguet propagation explains the observed accelerative expansion. Potential richness in incorporating reactive fronts in the description of various astronomical phenomena is expected. © 2011 American Physical Society

Equations of motion of the lunar roving vehicle.

NASA Technical Reports Server (NTRS)

Kaufman, S.

1973-01-01

Equations of motion have been formulated for a four-wheel vehicle as it traverses a terrain characterized by slopes, craters, bumps, washboards, or a power spectrum. Independent suspension and electric motor propulsion are considered. These equations were programmed on the UNIVAC 1108 digital computer. Results are given for the steerability of the Lunar Roving Vehicle (LRV) which was found to be satisfactory for normal operating speeds and turning radii. The vehicle was also found to be satisfactory against overturning in both the pitch and roll mode, and results are presented for various speeds as the LRV engages a bump on meter in diameter and of varying heights. Speed, power consumption, and load characteristics are presented for the LRV traversing a simulated lunar soil at full throttle. Comparisons are given against data compiled from the Apollo 15 mission.

Precision probes of QCD at high energies

DOE PAGES

Alioli, Simone; Farina, Marco; Pappadopulo, Duccio; ...

2017-07-20

New physics, that is too heavy to be produced directly, can leave measurable imprints on the tails of kinematic distributions at the LHC.We use energetic QCD processes to perform novel measurements of the Standard Model (SM) Effective Field Theory. We show that the dijet invariant mass spectrum, and the inclusive jet transverse momentum spectrum, are sensitive to a dimension 6 operator that modifies the gluon propagator at high energies. The dominant effect is constructive or destructive interference with SM jet production. Here, we compare differential next-to-leading order predictions from POWHEG to public 7TeV jet data, including scale, PDF, and experimentalmore » uncertainties and their respective correlations. Furthermore, we constrain a New Physics (NP) scale of 3.5TeV with current data. We project the reach of future 13 and 100TeV measurements, which we estimate to be sensitive to NP scales of 8 and 60TeV, respectively. As an application, we apply our bounds to constrain heavy vector octet colorons that couple to the QCD current. We conclude that effective operators will surpass bump hunts, in terms of coloron mass reach, even for sequential couplings.« less

Perspective on the Cosmic-ray Electron Spectrum above TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Kun; Wang, Bing-Bing; Bi, Xiao-Jun

2017-02-20

The AMS-02 has measured the cosmic-ray electron (plus positron) spectrum up to ∼TeV with unprecedented precision. The spectrum can be well described by a power law without any obvious features above 10 GeV. The satellite instrument Dark Matter Particle Explorer (DAMPE), which was launched a year ago, will measure the electron spectrum up to 10 TeV with high-energy resolution. The cosmic electrons beyond TeV may be attributed to few local cosmic-ray sources, such as supernova remnants. Therefore, spectral features, such as cut-off and bumps, can be expected at high energies. In this work, we provide a careful study on themore » perspective of the electron spectrum beyond TeV. We first examine our astrophysical source models on the latest leptonic data of AMS-02 to give a self-consistent picture. Then we focus on the discussion about the candidate sources, which could be electron contributors above TeV. Depending on the properties of the local sources (especially on the nature of Vela), DAMPE may detect interesting features in the electron spectrum above TeV in the future.« less

NASA Tech Briefs, June 2009

NASA Technical Reports Server (NTRS)

2009-01-01

Topics covered include: Device for Measuring Low Flow Speed in a Duct, Measuring Thermal Conductivity of a Small Insulation Sample, Alignment Jig for the Precise Measurement of THz Radiation, Autoignition Chamber for Remote Testing of Pyrotechnic Devices, Microwave Power Combiners for Signals of Arbitrary Amplitude, Synthetic Foveal Imaging Technology, Airborne Antenna System for Minimum-Cycle-Slip GPS Reception, Improved Starting Materials for Back-Illuminated Imagers, Multi-Modulator for Bandwidth-Efficient Communication, Some Improvements in Utilization of Flash Memory Devices, GPS/MEMS IMU/Microprocessor Board for Navigation, T/R Multi-Chip MMIC Modules for 150 GHz, Pneumatic Haptic Interfaces, Device Acquires and Retains Rock or Ice Samples, Cryogenic Feedthrough Test Rig, Improved Assembly for Gas Shielding During Welding or Brazing, Two-Step Plasma Process for Cleaning Indium Bonding Bumps, Tool for Crimping Flexible Circuit Leads, Yb14MnSb11 as a High-Efficiency Thermoelectric Material, Polyimide-Foam/Aerogel Composites for Thermal Insulation, Converting CSV Files to RKSML Files, Service Management Database for DSN Equipment, Chemochromic Hydrogen Leak Detectors, Compatibility of Segments of Thermoelectric Generators, Complementary Barrier Infrared Detector, JPL Greenland Moulin Exploration Probe, Ultra-Lightweight Self-Deployable Nanocomposite Structure for Habitat Applications, and Room-Temperature Ionic Liquids for Electrochemical Capacitors.

Direct /sup 125/I-radioligand assays for serum progesterone compared with assays involving extraction of serum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratcliffe, W.A.; Corrie, J.E.; Dalziel, A.H.

1982-06-01

Researchers compared two direct radioimmunoassays for progesterone in 50 microL of unextracted serum or plasma with assays involving extraction of serum. The direct assays include the use of either danazol at pH 7.4 or 8-anilino-1-naphthalenesulfonic acid at pH 4.0 to displace progesterone from serum binding-proteins. Progesterone is then assayed by using an antiserum to a progesterone 11 alpha hemisuccinyl conjugate and the radioligand /sup 125/I-labeled progesterone 11 alpha-glucuronyl tyramine, with separation by double-antibody techniques. Direct assays with either displacing agent gave good analytical recovery of progesterone added to human serum, and progesterone values for patients' specimens correlated well (r greatermore » than 0.96) with results of assays involving extraction of serum. Precision was similar with each displacing agent over the working range 2.5-100 nmol/L and superior to that of extraction assays. Researchers conclude that these direct assays of progesterone are analytically valid and more robust, precise, and technically convenient than many conventional methods involving extraction of serum.« less

Direct /sup 125/I-radioligand assays for serum progesterone compared with assays involving extraction of serum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratcliffe, W.A.; Corrie, J.E.T.; Dalziel, A.H.

1982-06-01

Two direct radioimmunoassays for progesterone in 50 ..mu..L of unextracted serum or plasma with assays involving extraction of serum were compared. The direct assays include the use of either danazol at pH 7.4 or 8-anilino-1-naphthalenesulfonic acid at pH 4.0 to displace progesterone from serum binding-proteins. Progesterone is then assayed by using an antiserum to a progesterone 11..cap alpha..-hemisuccinyl conjugate and the radioligand /sup 125/I-labeled progesterone 11..cap alpha..-glucuronyl tyramine, with separation by double-antibody techniques. Direct assays with either displacing agent gave good analytical recovery of progesterone added to human serum, and progesterone values for patients' specimens correlated well (r > 0.96)more » with results of assays involving extraction of serum. Precision was similar with each displacing agent over the working range 2.5-100 nmol/L and superior to that of extraction assays. We conclude that these direct assays of progesterone are analytically valid and more robust, precise, and technically convenient than many conventional methods involving extraction of serum.« less

SHARDS: constraints on the dust attenuation law of star-forming galaxies at z ˜ 2

NASA Astrophysics Data System (ADS)

Tress, Mónica; Mármol-Queraltó, Esther; Ferreras, Ignacio; Pérez-González, Pablo G.; Barro, Guillermo; Pampliega, Belén Alcalde; Cava, Antonio; Domínguez-Sánchez, Helena; Eliche-Moral, Carmen; Espino-Briones, Néstor; Esquej, Pilar; Hernán-Caballero, Antonio; Rodighiero, Giulia; Rodriguez-Muñoz, Lucía

2018-04-01

We make use of the Survey of High-z Absorption Red and Dead Sources, an ultradeep (<26.5AB) galaxy survey that provides optical photospectra at resolution R ˜ 50, via medium-band filters (FWHM ˜ 150 Å). This data set is combined with ancillary optical and NIR fluxes to constrain the dust attenuation law in the rest-frame NUV region of star-forming galaxies within the redshift window 1.5 < z < 3. We focus on the NUV bump strength (B) and the total-to-selective extinction ratio (RV), targeting a sample of 1753 galaxies. By comparing the data with a set of population synthesis models coupled to a parametric dust attenuation law, we constrain RV and B, as well as the colour excess, E(B - V). We find a correlation between RV and B, which can be interpreted either as a result of the grain size distribution, or a variation of the dust geometry among galaxies. According to the former, small dust grains are associated with a stronger NUV bump. The latter would lead to a range of clumpiness in the distribution of dust within the interstellar medium of star-forming galaxies. The observed wide range of NUV bump strengths can lead to a systematic in the interpretation of the UV slope β typically used to characterize the dust content. In this study, we quantify these variations, concluding that the effects are Δβ ˜ 0.4.

Reconstruction of primordial tensor power spectra from B -mode polarization of the cosmic microwave background

NASA Astrophysics Data System (ADS)

Hiramatsu, Takashi; Komatsu, Eiichiro; Hazumi, Masashi; Sasaki, Misao

2018-06-01

Given observations of the B -mode polarization power spectrum of the cosmic microwave background (CMB), we can reconstruct power spectra of primordial tensor modes from the early Universe without assuming their functional form such as a power-law spectrum. The shape of the reconstructed spectra can then be used to probe the origin of tensor modes in a model-independent manner. We use the Fisher matrix to calculate the covariance matrix of tensor power spectra reconstructed in bins. We find that the power spectra are best reconstructed at wave numbers in the vicinity of k ≈6 ×10-4 and 5 ×10-3 Mpc-1 , which correspond to the "reionization bump" at ℓ≲6 and "recombination bump" at ℓ≈80 of the CMB B -mode power spectrum, respectively. The error bar between these two wave numbers is larger because of the lack of the signal between the reionization and recombination bumps. The error bars increase sharply toward smaller (larger) wave numbers because of the cosmic variance (CMB lensing and instrumental noise). To demonstrate the utility of the reconstructed power spectra, we investigate whether we can distinguish between various sources of tensor modes including those from the vacuum metric fluctuation and SU(2) gauge fields during single-field slow-roll inflation, open inflation, and massive gravity inflation. The results depend on the model parameters, but we find that future CMB experiments are sensitive to differences in these models. We make our calculation tool available online.

Sensory feedback in a bump attractor model of path integration.

PubMed

Poll, Daniel B; Nguyen, Khanh; Kilpatrick, Zachary P

2016-04-01

Mammalian spatial navigation systems utilize several different sensory information channels. This information is converted into a neural code that represents the animal's current position in space by engaging place cell, grid cell, and head direction cell networks. In particular, sensory landmark (allothetic) cues can be utilized in concert with an animal's knowledge of its own velocity (idiothetic) cues to generate a more accurate representation of position than path integration provides on its own (Battaglia et al. The Journal of Neuroscience 24(19):4541-4550 (2004)). We develop a computational model that merges path integration with feedback from external sensory cues that provide a reliable representation of spatial position along an annular track. Starting with a continuous bump attractor model, we explore the impact of synaptic spatial asymmetry and heterogeneity, which disrupt the position code of the path integration process. We use asymptotic analysis to reduce the bump attractor model to a single scalar equation whose potential represents the impact of asymmetry and heterogeneity. Such imperfections cause errors to build up when the network performs path integration, but these errors can be corrected by an external control signal representing the effects of sensory cues. We demonstrate that there is an optimal strength and decay rate of the control signal when cues appear either periodically or randomly. A similar analysis is performed when errors in path integration arise from dynamic noise fluctuations. Again, there is an optimal strength and decay of discrete control that minimizes the path integration error.

Extraction of CYP chemical interactions from biomedical literature using natural language processing methods.

PubMed

Jiao, Dazhi; Wild, David J

2009-02-01

This paper proposes a system that automatically extracts CYP protein and chemical interactions from journal article abstracts, using natural language processing (NLP) and text mining methods. In our system, we employ a maximum entropy based learning method, using results from syntactic, semantic, and lexical analysis of texts. We first present our system architecture and then discuss the data set for training our machine learning based models and the methods in building components in our system, such as part of speech (POS) tagging, Named Entity Recognition (NER), dependency parsing, and relation extraction. An evaluation of the system is conducted at the end, yielding very promising results: The POS, dependency parsing, and NER components in our system have achieved a very high level of accuracy as measured by precision, ranging from 85.9% to 98.5%, and the precision and the recall of the interaction extraction component are 76.0% and 82.6%, and for the overall system are 68.4% and 72.2%, respectively.

Automated detection of lung nodules with three-dimensional convolutional neural networks

NASA Astrophysics Data System (ADS)

Pérez, Gustavo; Arbeláez, Pablo

2017-11-01

Lung cancer is the cancer type with highest mortality rate worldwide. It has been shown that early detection with computer tomography (CT) scans can reduce deaths caused by this disease. Manual detection of cancer nodules is costly and time-consuming. We present a general framework for the detection of nodules in lung CT images. Our method consists of the pre-processing of a patient's CT with filtering and lung extraction from the entire volume using a previously calculated mask for each patient. From the extracted lungs, we perform a candidate generation stage using morphological operations, followed by the training of a three-dimensional convolutional neural network for feature representation and classification of extracted candidates for false positive reduction. We perform experiments on the publicly available LIDC-IDRI dataset. Our candidate extraction approach is effective to produce precise candidates with a recall of 99.6%. In addition, false positive reduction stage manages to successfully classify candidates and increases precision by a factor of 7.000.

Determination of ractopamine in pig hair using liquid chromatography with tandem mass spectrometric detection.

PubMed

Wu, Junlin; Liu, Xiaoyun; Peng, Yunping

2014-01-01

A quantitative analytical procedure for the determination of ractopamine in pig hair has been developed and validated. The hair samples were washed and incubated at 75°C with isoxuprine and hair extraction buffer. The drug present was quantified using mixed solid-phase extraction and liquid chromatography with tandem mass spectrometric detection. The limit of quantization (LOQ) was 10pg/mg and the intra-day precision at 25pg/mg and 750pg/mg was 0.49% and 2.8% respectively. Inter-day precision was 0.88% and 3.52% at the same concentrations. The hair extraction percentage recovery at 25pg/mg and 50ng/mL was 99.47% and 103.83% respectively. The extraction percentage recovery at 25pg/mg and 50ng/mg was 93.52% and 100.26% respectively. Our results showed that ractopamine residues persist in hair in 24days of withdrawal and also showed the possibility to test ractopamine from pig hair samples. Copyright © 2014 Elsevier Inc. All rights reserved.

Cluster Headache

MedlinePlus

... after a head injury, even if it's a minor fall or bump, especially if it worsens A sudden, severe headache unlike any you've had A headache that worsens over days and changes in pattern Causes The exact cause of cluster ...

Block the Buzzing, Bites, and Bumps: Preventing Mosquito-Borne Illnesses

MedlinePlus

... Ten Mosquito Facts West Nile Virus Dengue Fever Malaria Zika Virus Infection Zika Virus Information and Resources References The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a ...

Genetics Home Reference: autosomal recessive hypotrichosis

MedlinePlus

... Autosomal recessive hypotrichosis is a condition that affects hair growth. People with this condition have sparse hair ( hypotrichosis ) ... erosions) on the scalp. In areas of poor hair growth, they may also develop bumps called hyperkeratotic follicular ...

Implementation impacts : volume 3, summer 2014.

DOT National Transportation Integrated Search

2014-01-01

Summary of research projects at the Louisiana Transportation Research Center. Projects in this issue include: Edge Lines Reduce the : Number of Crashes on : Rural Two-lane Highways; New Approach Slab Design Decreases Bridge Bumps : in the Road;...

Simultaneous Determination of Crypto-Chlorogenic Acid, Isoquercetin, and Astragalin Contents in Moringa oleifera Leaf Extracts by TLC-Densitometric Method

PubMed Central

Vongsak, Boonyadist; Sithisarn, Pongtip; Gritsanapan, Wandee

2013-01-01

Moringa oleifera Lamarck (Moringaceae) is used as a multipurpose medicinal plant for the treatment of various diseases. Isoquercetin, astragalin, and crypto-chlorogenic acid have been previously found to be major active components in the leaves of this plant. In this study, a thin-layer-chromatography (TLC-)densitometric method was developed and validated for simultaneous quantification of these major components in the 70% ethanolic extracts of M. oleifera leaves collected from 12 locations. The average amounts of crypto-chlorogenic acid, isoquercetin, and astragalin were found to be 0.0473, 0.0427, and 0.0534% dry weight, respectively. The method was validated for linearity, precision, accuracy, limit of detection, limit of quantitation, and robustness. The linearity was obtained in the range of 100–500 ng/spot with a correlation coefficient (r) over 0.9961. Intraday and interday precisions demonstrated relative standard deviations of less than 5%. The accuracy of the method was confirmed by determining the recovery. The average recoveries of each component from the extracts were in the range of 98.28 to 99.65%. Additionally, the leaves from Chiang Mai province contained the highest amounts of all active components. The proposed TLC-densitometric method was simple, accurate, precise, and cost-effective for routine quality controlling of M. oleifera leaf extracts. PMID:23533530

Unsupervised Extraction of Diagnosis Codes from EMRs Using Knowledge-Based and Extractive Text Summarization Techniques

PubMed Central

Kavuluru, Ramakanth; Han, Sifei; Harris, Daniel

2017-01-01

Diagnosis codes are extracted from medical records for billing and reimbursement and for secondary uses such as quality control and cohort identification. In the US, these codes come from the standard terminology ICD-9-CM derived from the international classification of diseases (ICD). ICD-9 codes are generally extracted by trained human coders by reading all artifacts available in a patient’s medical record following specific coding guidelines. To assist coders in this manual process, this paper proposes an unsupervised ensemble approach to automatically extract ICD-9 diagnosis codes from textual narratives included in electronic medical records (EMRs). Earlier attempts on automatic extraction focused on individual documents such as radiology reports and discharge summaries. Here we use a more realistic dataset and extract ICD-9 codes from EMRs of 1000 inpatient visits at the University of Kentucky Medical Center. Using named entity recognition (NER), graph-based concept-mapping of medical concepts, and extractive text summarization techniques, we achieve an example based average recall of 0.42 with average precision 0.47; compared with a baseline of using only NER, we notice a 12% improvement in recall with the graph-based approach and a 7% improvement in precision using the extractive text summarization approach. Although diagnosis codes are complex concepts often expressed in text with significant long range non-local dependencies, our present work shows the potential of unsupervised methods in extracting a portion of codes. As such, our findings are especially relevant for code extraction tasks where obtaining large amounts of training data is difficult. PMID:28748227

[Determination of four bisphenolic compounds in drinking water by liquid chromatography-tandem mass spectrometry].

PubMed

Hu, Xiaojian; Zhang, Haijing; Wang, Xiaohong; Ding, Changming; Lin, Shaobin

2015-05-01

To simultaneously determine the four bisphenolic compounds (bisphenol F, bisphenol A, tetrachlorobisphenol A and tetrabromobisphenol A) in drinking water by liquid chromatography tandem mass spectrometry. 200 ml water sample was extracted by solid-phase extraction, eluted with methanol and analyzed by liquid chromatography tandem mass spectrometry under the MRM mode. The separation was carried out on a T3 column (2.1 mm x 150 mm, 3 μm). The limits of detection for the four bisphenolic compounds were in the range of 0.20 - 5.5 ng/L. The mean recoveries at the two spiked levels were 87.1% - 109.0% with the intra-day precision between 6.3% - 12.4% and inter-day precision between 4.5% - 15.4%. The method was applied for determination of 15 water samples. The method was sensitive, precise and accurate.

Estimation of L-dopa from Mucuna pruriens LINN and formulations containing M. pruriens by HPTLC method.

PubMed

Modi, Ketan Pravinbhai; Patel, Natvarlal Manilal; Goyal, Ramesh Kishorilal

2008-03-01

A selective, precise, and accurate high-performance thin-layer chromatographic (HPTLC) method has been developed for the analysis of L-dopa in Mucuna pruriens seed extract and its formulations. The method involves densitometric evaluation of L-dopa after resolving it by HPTLC on silica gel plates with n-butanol-acetic acid-water (4.0+1.0+1.0, v/v) as the mobile phase. Densitometric analysis of L-dopa was carried out in the absorbance mode at 280 nm. The relationship between the concentration of L-dopa and corresponding peak areas was found to be linear in the range of 100 to 1200 ng/spot. The method was validated for precision (inter and intraday), repeatability, and accuracy. Mean recovery was 100.30%. The relative standard deviation (RSD) values of the precision were found to be in the range 0.64-1.52%. In conclusion, the proposed TLC method was found to be precise, specific and accurate and can be used for identification and quantitative determination of L-dopa in herbal extract and its formulations.

Web-Based Urban Metabolic Mapping for Bangalore, India

NASA Astrophysics Data System (ADS)

Mehta, V. K.; Kemp-Benedict, E.; Wang, G.; Malghan, D.

2012-12-01

Cities are like living entities, needing a continuous throughput of resources and energy for survival and growth, creating waste in the process. This paper documents the Bangalore Urban Mapping Project: an initiative that uses this metabolic concept [1],[2]. to inform comprehensive planning in the rapidly growing software capital of Bangalore city in India. Focusing on demographic growth, and water supply and consumption in its first phase, a web-based geo-portal has been developed for two purposes - interactive information communication and delivery, and online planning in the water supply sector. The application, titled Bangalore Urban Mapping Project (BUMP) is built on a free and open source web GIS stack consisting of a Postgis database, PHP, OpenLayers, and Apache Web Server deployed on a 64-bit Ubuntu Linux server platform. The interactive planning portion of the application allows BUMP users to build, run and visualize demographic growth, water supply, and growth scenarios on the browser. Application logic is written in PHP to connect the many components of the interactive application, which is available on the BUMP website (http://www.seimapping.org/bump/index.php). It relies on AJAX to fetch layer data from the server and render the layer using OpenLayers on the fly. This allows users to view multiple layers at the same time without refreshing the page. Data is packed in GeoJSON format and is compressed to reduce traffic. The information communication portion of the application provides thematic representation of each of twenty different map layers, graphical and tabular summaries of demographic and water data that are presented dynamically using Javascript libraries including the Google Chart API. The application also uses other common Javascript libraries/plug-ins, like jQuery, jQuery UI, qTip, to ease the development and to ensure cross-browser compatibility. The planning portion of the platform allows the user to interact with a scenario explorer through which key aspects of the city's growth, water demand, and supply infrastructure can be entered. This drives a water resources model built on the Water Evaluation And Planning (www.weap21.org) software platform [3] running on a server, that returns key results to the browser. The paper concludes with plans for future development of BUMP, which include crowd-sourcing of water demand and groundwater information, in the face of a critical knowledge gap on both the demand and supply side of the water sector in Indian cities. [1] Newman, P.W.G., 1999. Sustainability and cities: extending the metabolism model. Landscape and urban planning 44, 219-226. [2] Sieferle, R.P., 2011. Cultural Evolution and Social Metabolism. Geografiska Annaler: Series B, Human Geography [3] 93, 315-324. Yates, D., Sieber, J., Purkey, D., Huber-Lee, A., 2005. WEAP21—A Demand-, Priority-, and Preference-Driven Water Planning Model. Water International 30, 487-500.

Determination of perfluorinated compounds in fish fillet homogenates: method validation and application to fillet homogenates from the Mississippi River.

PubMed

Malinsky, Michelle Duval; Jacoby, Cliffton B; Reagen, William K

2011-01-10

We report herein a simple protein precipitation extraction-liquid chromatography tandem mass spectrometry (LC/MS/MS) method, validation, and application for the analysis of perfluorinated carboxylic acids (C7-C12), perfluorinated sulfonic acids (C4, C6, and C8), and perfluorooctane sulfonamide (FOSA) in fish fillet tissue. The method combines a rapid homogenization and protein precipitation tissue extraction procedure using stable-isotope internal standard (IS) calibration. Method validation in bluegill (Lepomis macrochirus) fillet tissue evaluated the following: (1) method accuracy and precision in both extracted matrix-matched calibration and solvent (unextracted) calibration, (2) quantitation of mixed branched and linear isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) with linear isomer calibration, (3) quantitation of low level (ppb) perfluorinated compounds (PFCs) in the presence of high level (ppm) PFOS, and (4) specificity from matrix interferences. Both calibration techniques produced method accuracy of at least 100±13% with a precision (%RSD) ≤18% for all target analytes. Method accuracy and precision results for fillet samples from nine different fish species taken from the Mississippi River in 2008 and 2009 are also presented. Copyright © 2010 Elsevier B.V. All rights reserved.

Quantitative analysis of three chiral pesticide enantiomers by high-performance column liquid chromatography.

PubMed

Wang, Peng; Liu, Donghui; Gu, Xu; Jiang, Shuren; Zhou, Zhiqiang

2008-01-01

Methods for the enantiomeric quantitative determination of 3 chiral pesticides, paclobutrazol, myclobutanil, and uniconazole, and their residues in soil and water are reported. An effective chiral high-performance liquid chromatographic (HPLC)-UV method using an amylose-tris(3,5-dimethylphenylcarbamate; AD) column was developed for resolving the enantiomers and quantitative determination. The enantiomers were identified by a circular dichroism detector. Validation involved complete resolution of each of the 2 enantiomers, plus determination of linearity, precision, and limit of detection (LOD). The pesticide enantiomers were isolated by solvent extraction from soil and C18 solid-phase extraction from water. The 2 enantiomers of the 3 pesticides could be completely separated on the AD column using n-hexane isopropanol mobile phase. The linearity and precision results indicated that the method was reliable for the quantitative analysis of the enantiomers. LODs were 0.025, 0.05, and 0.05 mg/kg for each enantiomer of paclobutrazol, myclobutanil, and uniconazole, respectively. Recovery and precision data showed that the pretreatment procedures were satisfactory for enantiomer extraction and cleanup. This method can be used for optical purity determination of technical material and analysis of environmental residues.

Tick Talk: Block Tick Bites and Lyme Disease

MedlinePlus

... Subscribe May 2014 Print this issue Tick Talk Block Tick Bites and Lyme Disease En español Send ... Health Researchers Examine the Structure of Zika Virus Block the Buzzing, Bites, and Bumps Wise Choices To ...

Latex Allergy

MedlinePlus

... the material touches the skin. This is called contact dermatitis. Red, itchy bumps or blisters usually appear within ... powdered gloves are used and avoid all direct contact with latex. ... to get a skin rash reaction to latex, latex gloves made without additional ...

Eyelid bump

MedlinePlus

... 423. Review Date 8/20/2016 Updated by: Franklin W. Lusby, MD, ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Eyelid Disorders Read more ...

The influence of dynamical friction and mean motion resonances on terrestrial planet growth

NASA Astrophysics Data System (ADS)

Wallace, Spencer Clark; Quinn, Thomas R.

2018-04-01

We present a set of high-resolution direct N-body simulations of planetesimal coagulation at 1 AU. We follow the evolution of of 1 million planetesimals in a ring though the runaway and oligarchic growth phases. During oligarchic growth, the size frequency distribution (SFD) of planetesimals develops a bump at intermediate masses, which we argue is due to dynamical friction acting through mean motion resonances, heating the low mass planetesimals and inhibiting their growth. This feature is similar to the bump seen in the SFD of asteroid belt and Kuiper belt objects and we argue that a careful treatment of the dynamics of planetesimal interactions is required in order to adequately explain the observed SFD. Although our model does not account for fragmentation, our results show that a similar feature can be produced without it, which is in contention with previous studies.

Comparative pulsation calculations with OP and OPAL opacities

NASA Technical Reports Server (NTRS)

Kanbur, Shashi M.; Simon, Norman R.

1994-01-01

Comparative linear nonadiabatic pulsation calculations are presented using the OPAL and Opacity Project opacities. The two sets of opacities include effects due to intermediate coupling and fine structure as well as new abundances. We used two mass luminosity (M-L) relations, one standard (BIT), and one employing substantial convective core overshoot (COV). The two sets of opacities cannot be differentiated on the basis of the stellar pulsation calculations presented here. The BIT relation can model the beat and bump Cepheids with masses between 4 and 7 solar mass, while if the overshoot relation is used, masses between 2 and 6 solar mass are required. In the RR Lyrae regime, we find the inferred masses of globular cluster RRd stars to be little influenced by the choice of OPAL or OP. Finally, the limited modeling we have done is not able to constrain the Cepheid M-L relation based upon period ratios observed in the beat and bump stars.

Simulation studies of plasma waves in the electron foreshock - The generation of downshifted oscillations

NASA Technical Reports Server (NTRS)

Dum, C. T.

1990-01-01

The generation of waves with frequencies downshifted from the plasma frequency, as observed in the electron foreshock, is analyzed by particle simulation. Wave excitation differs fundamentally from the familiar excitation of the plasma eigenmodes by a gentle bump-on-tail electron distribution. Beam modes are destabilized by resonant interaction with bulk electrons, provided the beam velocity spread is very small. These modes are stabilized, starting with the higher frequencies, as the beam is broadened and slowed down by the interaction with the wave spectrum. Initially a very cold beam is also capable of exciting frequencies considerably above the plasma frequency, but such oscillations are quickly stabilized. Low-frequency modes persist for a long time, until the bump in the electron distribution is completely 'ironed' out. This diffusion process also is quite different from the familiar case of well-separated beam and bulk electrons. A quantitative analysis of these processes is carried out.

Decapsulation Method for Flip Chips with Ceramics in Microelectronic Packaging

NASA Astrophysics Data System (ADS)

Shih, T. I.; Duh, J. G.

2008-06-01

The decapsulation of flip chips bonded to ceramic substrates is a challenging task in the packaging industry owing to the vulnerability of the chip surface during the process. In conventional methods, such as manual grinding and polishing, the solder bumps are easily damaged during the removal of underfill, and the thin chip may even be crushed due to mechanical stress. An efficient and reliable decapsulation method consisting of thermal and chemical processes was developed in this study. The surface quality of chips after solder removal is satisfactory for the existing solder rework procedure as well as for die-level failure analysis. The innovative processes included heat-sink and ceramic substrate removal, solder bump separation, and solder residue cleaning from the chip surface. In the last stage, particular temperatures were selected for the removal of eutectic Pb-Sn, high-lead, and lead-free solders considering their respective melting points.

Sequential shrink photolithography for plastic microlens arrays

NASA Astrophysics Data System (ADS)

Dyer, David; Shreim, Samir; Jayadev, Shreshta; Lew, Valerie; Botvinick, Elliot; Khine, Michelle

2011-07-01

Endeavoring to push the boundaries of microfabrication with shrinkable polymers, we have developed a sequential shrink photolithography process. We demonstrate the utility of this approach by rapidly fabricating plastic microlens arrays. First, we create a mask out of the children's toy Shrinky Dinks by simply printing dots using a standard desktop printer. Upon retraction of this pre-stressed thermoplastic sheet, the dots shrink to a fraction of their original size, which we then lithographically transfer onto photoresist-coated commodity shrink wrap film. This shrink film reduces in area by 95% when briefly heated, creating smooth convex photoresist bumps down to 30 µm. Taken together, this sequential shrink process provides a complete process to create microlenses, with an almost 99% reduction in area from the original pattern size. Finally, with a lithography molding step, we emboss these bumps into optical grade plastics such as cyclic olefin copolymer for functional microlens arrays.

Application of I-structure though-glass interconnect filled with submicron gold particles to a hermetic sealing device

NASA Astrophysics Data System (ADS)

Nomura, Kazuya; Okada, Akiko; Shoji, Shuichi; Ogashiwa, Toshinori; Mizuno, Jun

2016-10-01

We propose hermetic sealing of a glass-to-glass structure with an I-structure through-glass interconnect via (TGV) filled with submicron Au particles. The top and bottom bumps and the TGV were formed by a simple filling process with a bump-patterned dry film resist. The sealing devices consisting of two glass substrates were bonded via Au interlayers. Vacuum ultraviolet irradiation in the presence of oxygen gas (VUV/O3) pretreatment was used for low-temperature Au-Au bonding at 200 °C. The bonded samples showed He leakage rates of less than 1.3  ×  10-9 Pa m3 s-1. The cross-sectional scanning electron microscope images of the fabricated I-structure TGV showed perfect adhesion between the I-structure TGV and glass substrate. These results indicate that the proposed I-structure TGV is suitable for hermetic sealing devices.

Feeling socially powerless makes you more prone to bumping into things on the right and induces leftward line bisection error.

PubMed

Wilkinson, David; Guinote, Ana; Weick, Mario; Molinari, Rosanna; Graham, Kylee

2010-12-01

Social power affects the manner in which people view themselves and act toward others, a finding that has attracted broad interest from the social and political sciences. However, there has been little interest from those within cognitive neuroscience. Here, we demonstrate that the effects of power extend beyond social interaction and invoke elementary spatial biases in behavior consistent with preferential hemispheric activation. In particular, participants who felt relatively powerless, compared with those who felt more powerful, were more likely to bisect horizontal lines to the left of center, and bump into the right-hand (as opposed to the left-hand) side when walking through a narrow passage. These results suggest that power induces hemispheric differences in visuomotor behavior, indicating that this ubiquitous phenomenon affects not only how we interact with one another, but also how we interact with the physical world.

Method to simulate and analyse induced stresses for laser crystal packaging technologies.

PubMed

Ribes-Pleguezuelo, Pol; Zhang, Site; Beckert, Erik; Eberhardt, Ramona; Wyrowski, Frank; Tünnermann, Andreas

2017-03-20

A method to simulate induced stresses for a laser crystal packaging technique and the consequent study of birefringent effects inside the laser cavities has been developed. The method has been implemented by thermo-mechanical simulations implemented with ANSYS 17.0. ANSYS results were later imported in VirtualLab Fusion software where input/output beams in terms of wavelengths and polarization were analysed. The study has been built in the context of a low-stress soldering technique implemented for glass or crystal optics packaging's called the solderjet bumping technique. The outcome of the analysis showed almost no difference between the input and output laser beams for the laser cavity constructed with an yttrium aluminum garnet active laser crystal, a second harmonic generator beta-barium borate, and the output laser mirror made of fused silica assembled by the low-stress solderjet bumping technique.

Sequential shrink photolithography for plastic microlens arrays.

PubMed

Dyer, David; Shreim, Samir; Jayadev, Shreshta; Lew, Valerie; Botvinick, Elliot; Khine, Michelle

2011-07-18

Endeavoring to push the boundaries of microfabrication with shrinkable polymers, we have developed a sequential shrink photolithography process. We demonstrate the utility of this approach by rapidly fabricating plastic microlens arrays. First, we create a mask out of the children's toy Shrinky Dinks by simply printing dots using a standard desktop printer. Upon retraction of this pre-stressed thermoplastic sheet, the dots shrink to a fraction of their original size, which we then lithographically transfer onto photoresist-coated commodity shrink wrap film. This shrink film reduces in area by 95% when briefly heated, creating smooth convex photoresist bumps down to 30 µm. Taken together, this sequential shrink process provides a complete process to create microlenses, with an almost 99% reduction in area from the original pattern size. Finally, with a lithography molding step, we emboss these bumps into optical grade plastics such as cyclic olefin copolymer for functional microlens arrays.

Sequential shrink photolithography for plastic microlens arrays

PubMed Central

Dyer, David; Shreim, Samir; Jayadev, Shreshta; Lew, Valerie; Botvinick, Elliot; Khine, Michelle

2011-01-01

Endeavoring to push the boundaries of microfabrication with shrinkable polymers, we have developed a sequential shrink photolithography process. We demonstrate the utility of this approach by rapidly fabricating plastic microlens arrays. First, we create a mask out of the children’s toy Shrinky Dinks by simply printing dots using a standard desktop printer. Upon retraction of this pre-stressed thermoplastic sheet, the dots shrink to a fraction of their original size, which we then lithographically transfer onto photoresist-coated commodity shrink wrap film. This shrink film reduces in area by 95% when briefly heated, creating smooth convex photoresist bumps down to 30 µm. Taken together, this sequential shrink process provides a complete process to create microlenses, with an almost 99% reduction in area from the original pattern size. Finally, with a lithography molding step, we emboss these bumps into optical grade plastics such as cyclic olefin copolymer for functional microlens arrays. PMID:21863126

Sonography of pediatric superficial lumps and bumps: illustrative examples from head to toe.

PubMed

Bansal, Anmol Gupta; Rosenberg, Henrietta Kotlus

2017-08-01

Superficial lumps and bumps are extremely common in children, and the vast majority ultimately prove to be benign. Duplex/color Doppler ultrasound (US) has emerged as the first-line imaging modality for the evaluation of these superficial pediatric masses because it provides a means for rapid acquisition of information including size, shape, location, internal content and vascularity. More important, it does so without utilizing radiation, iodinated contrast material or sedation/anesthesia. In this review, we present the sonographic findings of a variety of cases ranging from head to toe that are either uncommonly seen or were diagnosed in an atypical fashion (i.e. ultrasound). In situations where the lesion is too deep, hyperechoic or large to be fully assessed within the field of view or if malignancy is suspected, then additional cross-sectional imaging is warranted for further evaluation.

A comparison of the aerodynamic characteristics at transonic speeds of four wing-fuselage configurations as determined from different test techniques, 4 October 1960

NASA Technical Reports Server (NTRS)

Donlan, C. J.; Myers, B. C., II; Mattson, A. T.

1976-01-01

The high speed aerodynamic characteristics of a family of four wing-fuselage configurations of 0, 35, 45, and 60 deg sweepback were determined from transonic bump model tests that were conducted in the Langley high speed 7 by 10 foot tunnel; sting supported model tests were conducted in the Langley 8 foot high speed tunnel and in the Langley high speed 7 by 10 foot tunnel, and rocket model tests were conducted by the Langley Pilotless Aircraft Research Division. A complementary study of the effect of Mach number gradients and streamline curvature on bump results is also included. The qualitative data obtained from the various test facilities for the wing-fuselage configurations were in essential agreement as regards the relative effects of sweepback and Mach number except for drag at zero lift. Quantitatively, important differences were present.

Saturation of the junction voltage in GaN-based laser diodes

NASA Astrophysics Data System (ADS)

Feng, M. X.; Liu, J. P.; Zhang, S. M.; Liu, Z. S.; Jiang, D. S.; Li, Z. C.; Wang, F.; Li, D. Y.; Zhang, L. Q.; Wang, H.; Yang, H.

2013-05-01

Saturation of the junction voltage in GaN-based laser diodes (LDs) is studied. It is found that there is a bump above the lasing transition in the I(dV/dI)-I curve, instead of a dip as that for GaAs-based LDs. The bump in I(dV/dI)-I curve moves to higher currents along with the lasing threshold. A model considering ambipolar conduction and electron overflow into p-AlGaN cladding layer due to poor carrier confinement in active region is used to explain the anomaly. The characteristic temperature of GaN-based LD is obtained by fitting threshold currents determined from I(dV/dI)-I curves. Moreover, it is found that GaN-based LDs show characteristics with a nonlinear series resistance, which may be due to the electron overflow into p-AlGaN cladding layer and the enhanced activation of Mg acceptors.

The effects on cruise drag of installing long-duct refan-engine nacelles on the McDonnell Douglas DC-8-50 and -61

NASA Technical Reports Server (NTRS)

Callaghan, J. T.; Donelson, J. E.; Morelli, J. P.

1973-01-01

A high-speed wind tunnel test was conducted to determine the effect on cruise performance of installing long-duct refan-engine nacelles on the DC-8-50 and -61 models. Drag data and wing/pylon/nacelle channel pressure data are presented. At a typical cruise condition there exists a very small interference drag penalty of less than one-percent of total cruise data for the Refan installation. Pressure data indicate that some supersonic flow is present in the inboard channel of the inboard refan nacelle installation, but it is not sufficient to cause any wave drag on boundary layer separation. One pylon modification, which takes the form of pylon bumps, was tested. It resulted in a drag penalty, because its design goal of eliminating shock-related interference drag was not required and the bump thus became a source of additional parasite drag.

On-road anomaly detection by multimodal sensor analysis and multimedia processing

NASA Astrophysics Data System (ADS)

Orhan, Fatih; Eren, P. E.

2014-03-01

The use of smartphones in Intelligent Transportation Systems is gaining popularity, yet many challenges exist in developing functional applications. Due to the dynamic nature of transportation, vehicular social applications face complexities such as developing robust sensor management, performing signal and image processing tasks, and sharing information among users. This study utilizes a multimodal sensor analysis framework which enables the analysis of sensors in multimodal aspect. It also provides plugin-based analyzing interfaces to develop sensor and image processing based applications, and connects its users via a centralized application as well as to social networks to facilitate communication and socialization. With the usage of this framework, an on-road anomaly detector is being developed and tested. The detector utilizes the sensors of a mobile device and is able to identify anomalies such as hard brake, pothole crossing, and speed bump crossing. Upon such detection, the video portion containing the anomaly is automatically extracted in order to enable further image processing analysis. The detection results are shared on a central portal application for online traffic condition monitoring.

SHiP: a new facility with a dedicated detector for studying tau neutrino properties

NASA Astrophysics Data System (ADS)

Komatsu, M.; SHiP Collaboration

2017-06-01

SHiP (Search for Hidden Particles) is a new general purpose fixed target facility at the CERN SPS accelerator, with the aim of search for New Physics which has small coupling with standard particles by searching for long lived beyond standard model particles with masses below a few GeV/c2. The SHiP facility is a high intensity beam bump, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 ×1020 pot in 5 years. A dedicated detector, based on the OPERA-like ECC (Emulsion Cloud Chamber), will provide tau and anti-tau neutrino detection capability to study ντ and ν‾τ cross-sections with a statistics a few 100 times larger than the DONUT experiment. Moreover, the structure functions F4 and F5 which is only accessible by tau neutrino interactions can be measured first time. SHiP is the unique chance to study tau and anti tau neutrino properties.

Doppler extraction with a digital VCO

NASA Technical Reports Server (NTRS)

Starner, E. R.; Nossen, E. J.

1977-01-01

Digitally controlled oscillator in phased-locked loop may be useful for data communications systems, or may be modified to serve as information extraction component of microwave or optical system for collision avoidance or automatic braking. Instrument is frequency-synthesizing device with output specified precisely by digital number programmed into frequency register.

Fast-adapting mechanoreceptors are important for force control in precision grip but not for sensorimotor memory.

PubMed

Park, Susanna B; Davare, Marco; Falla, Marika; Kennedy, William R; Selim, Mona M; Wendelschafer-Crabb, Gwen; Koltzenburg, Martin

2016-06-01

Sensory feedback from cutaneous mechanoreceptors in the fingertips is important in effective object manipulation, allowing appropriate scaling of grip and load forces during precision grip. However, the role of mechanoreceptor subtypes in these tasks remains incompletely understood. To address this issue, psychophysical tasks that may specifically assess function of type I fast-adapting (FAI) and slowly adapting (SAI) mechanoreceptors were used with object manipulation experiments to examine the regulation of grip force control in an experimental model of graded reduction in tactile sensitivity (healthy volunteers wearing 2 layers of latex gloves). With gloves, tactile sensitivity decreased significantly from 1.9 ± 0.4 to 12.3 ± 2.2 μm in the Bumps task assessing function of FAI afferents but not in a grating orientation task assessing SAI afferents (1.6 ± 0.1 to 1.8 ± 0.2 mm). Six axis force/torque sensors measured peak grip (PGF) and load (PLF) forces generated by the fingertips during a grip-lift task. With gloves there was a significant increase of PGF (14 ± 6%), PLF (17 ± 5%), and grip and load force rates (26 ± 8%, 20 ± 8%). A variable-weight series task was used to examine sensorimotor memory. There was a 20% increase in PGF when the lift of a light object was preceded by a heavy relative to a light object. This relationship was not significantly altered when lifting with gloves, suggesting that the addition of gloves did not change sensorimotor memory effects. We conclude that FAI fibers may be important for the online force scaling but not for the buildup of a sensorimotor memory. Copyright © 2016 the American Physiological Society.

Phosphorus Concentrations in Sequentially Fractionated Soil Samples as Affected by Digestion Methods

PubMed Central

do Nascimento, Carlos A. C.; Pagliari, Paulo H.; Schmitt, Djalma; He, Zhongqi; Waldrip, Heidi

2015-01-01

Sequential fractionation has helped improving our understanding of the lability and bioavailability of P in soil. Nevertheless, there have been no reports on how manipulation of the different fractions prior to analyses affects the total P (TP) concentrations measured. This study investigated the effects of sample digestion, filtration, and acidification on the TP concentrations determined by ICP-OES in 20 soil samples. Total P in extracts were either determined without digestion by ICP-OES, or ICP-OES following block digestion, or autoclave digestion. The effects of sample filtration, and acidification on undigested alkaline extracts prior to ICP-OES were also evaluated. Results showed that, TP concentrations were greatest in the block-digested extracts, though the variability introduced by the block-digestion was the highest. Acidification of NaHCO3 extracts resulted in lower TP concentrations, while acidification of NaOH randomly increased or decreased TP concentrations. The precision observed with ICP-OES of undigested extracts suggests this should be the preferred method for TP determination in sequentially extracted samples. Thus, observations reported in this work would be helpful in appropriate sample handling for P determination, thereby improving the precision of P determination. The results are also useful for literature data comparison and discussion when there are differences in sample treatments. PMID:26647644

Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.

We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The methodmore » consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.« less

Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

DOE PAGES

Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.; ...

2015-01-27

We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The methodmore » consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.« less

Random Photon Absorption Model Elucidates How Early Gain Control in Fly Photoreceptors Arises from Quantal Sampling

PubMed Central

Song, Zhuoyi; Zhou, Yu; Juusola, Mikko

2016-01-01

Many diurnal photoreceptors encode vast real-world light changes effectively, but how this performance originates from photon sampling is unclear. A 4-module biophysically-realistic fly photoreceptor model, in which information capture is limited by the number of its sampling units (microvilli) and their photon-hit recovery time (refractoriness), can accurately simulate real recordings and their information content. However, sublinear summation in quantum bump production (quantum-gain-nonlinearity) may also cause adaptation by reducing the bump/photon gain when multiple photons hit the same microvillus simultaneously. Here, we use a Random Photon Absorption Model (RandPAM), which is the 1st module of the 4-module fly photoreceptor model, to quantify the contribution of quantum-gain-nonlinearity in light adaptation. We show how quantum-gain-nonlinearity already results from photon sampling alone. In the extreme case, when two or more simultaneous photon-hits reduce to a single sublinear value, quantum-gain-nonlinearity is preset before the phototransduction reactions adapt the quantum bump waveform. However, the contribution of quantum-gain-nonlinearity in light adaptation depends upon the likelihood of multi-photon-hits, which is strictly determined by the number of microvilli and light intensity. Specifically, its contribution to light-adaptation is marginal (≤ 1%) in fly photoreceptors with many thousands of microvilli, because the probability of simultaneous multi-photon-hits on any one microvillus is low even during daylight conditions. However, in cells with fewer sampling units, the impact of quantum-gain-nonlinearity increases with brightening light. PMID:27445779

Cross-validation and Peeling Strategies for Survival Bump Hunting using Recursive Peeling Methods

PubMed Central

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

2015-01-01

We introduce a framework to build a survival/risk bump hunting model with a censored time-to-event response. Our Survival Bump Hunting (SBH) method is based on a recursive peeling procedure that uses a specific survival peeling criterion derived from non/semi-parametric statistics such as the hazards-ratio, the log-rank test or the Nelson--Aalen estimator. To optimize the tuning parameter of the model and validate it, we introduce an objective function based on survival or prediction-error statistics, such as the log-rank test and the concordance error rate. We also describe two alternative cross-validation techniques adapted to the joint task of decision-rule making by recursive peeling and survival estimation. Numerical analyses show the importance of replicated cross-validation and the differences between criteria and techniques in both low and high-dimensional settings. Although several non-parametric survival models exist, none addresses the problem of directly identifying local extrema. We show how SBH efficiently estimates extreme survival/risk subgroups unlike other models. This provides an insight into the behavior of commonly used models and suggests alternatives to be adopted in practice. Finally, our SBH framework was applied to a clinical dataset. In it, we identified subsets of patients characterized by clinical and demographic covariates with a distinct extreme survival outcome, for which tailored medical interventions could be made. An R package PRIMsrc (Patient Rule Induction Method in Survival, Regression and Classification settings) is available on CRAN (Comprehensive R Archive Network) and GitHub. PMID:27034730

Computational Aerothermodynamic Assessment of Space Shuttle Orbiter Tile Damage: Open Cavities

NASA Technical Reports Server (NTRS)

Pulsonetti, Maria; Wood, William

2005-01-01

Computational aerothermodynamic simulations of Orbiter windside tile damage in flight were performed in support of the Space Shuttle Return-to-Flight effort. The simulations were performed for both hypervelocity flight and low-enthalpy wind tunnel conditions and contributed to the Return-to-Flight program by providing information to support a variety of damage scenario analyses. Computations at flight conditions were performed at or very near the peak heating trajectory point for multiple damage scenarios involving damage windside acreage reaction cured glass (RCG) coated silica tile(s). The cavities formed by the missing tile examined in this study were relatively short leading to flow features which indicated open cavity behavior. Results of the computations indicated elevated heating bump factor levels predicted for flight over the predictions for wind tunnel conditions. The peak heating bump factors, defined as the local heating to a reference value upstream of the cavity, on the cavity floor for flight simulation were 67% larger than the peak wind tunnel simulation value. On the downstream face of the cavity the flight simulation values were 60% larger than the wind tunnel simulation values. On the outer mold line (OML) downstream of the cavity, the flight values are about 20% larger than the wind tunnel simulation values. The higher heating bump factors observed in the flight simulations were due to the larger driving potential in terms of energy entering the cavity for the flight simulations. This is evidenced by the larger rate of increase in the total enthalpy through the boundary layer prior to the cavity for the flight simulation.

Extraction of the neutron magnetic form factor from quasielastic 3He→(e→,e') at Q2=0.1-0.6(GeV/c)2

NASA Astrophysics Data System (ADS)

Anderson, B.; Auberbach, L.; Averett, T.; Bertozzi, W.; Black, T.; Calarco, J.; Cardman, L.; Cates, G. D.; Chai, Z. W.; Chen, J. P.; Choi, Seonho; Chudakov, E.; Churchwell, S.; Corrado, G. S.; Crawford, C.; Dale, D.; Deur, A.; Djawotho, P.; Dutta, D.; Finn, J. M.; Gao, H.; Gilman, R.; Glamazdin, A. V.; Glashausser, C.; Glöckle, W.; Golak, J.; Gomez, J.; Gorbenko, V. G.; Hansen, J.-O.; Hersman, F. W.; Higinbotham, D. W.; Holmes, R.; Howell, C. R.; Hughes, E.; Humensky, B.; Incerti, S.; Jager, C. W. De; Jensen, J. S.; Jiang, X.; Jones, C. E.; Jones, M.; Kahl, R.; Kamada, H.; Kievsky, A.; Kominis, I.; Korsch, W.; Kramer, K.; Kumbartzki, G.; Kuss, M.; Lakuriqi, E.; Liang, M.; Liyanage, N.; Lerose, J.; Malov, S.; Margaziotis, D. J.; Martin, J. W.; McCormick, K.; McKeown, R. D.; McIlhany, K.; Meziani, Z.-E.; Michaels, R.; Miller, G. W.; Mitchell, J.; Nanda, S.; Pace, E.; Pavlin, T.; Petratos, G. G.; Pomatsalyuk, R. I.; Pripstein, D.; Prout, D.; Ransome, R. D.; Roblin, Y.; Rvachev, M.; Saha, A.; Salmè, G.; Schnee, M.; Seely, J.; Shin, T.; Slifer, K.; Souder, P. A.; Strauch, S.; Suleiman, R.; Sutter, M.; Tipton, B.; Todor, L.; Viviani, M.; Vlahovic, B.; Watson, J.; Williamson, C. F.; Witała, H.; Wojtsekhowski, B.; Xiong, F.; Xu, W.; Yeh, J.; Żołnierczuk, P.

2007-03-01

We have measured the transverse asymmetry AT' in the quasielastic 3He→(e→,e') process with high precision at Q2 values from 0.1 to 0.6(GeV/c)2. The neutron magnetic form factor GMn was extracted at Q2 values of 0.1 and 0.2(GeV/c)2 using a nonrelativistic Faddeev calculation which includes both final-state interactions (FSI) and meson-exchange currents (MEC). Theoretical uncertainties due to the FSI and MEC effects were constrained with a precision measurement of the spin-dependent asymmetry in the threshold region of 3He→(e→,e'). We also extracted the neutron magnetic form factor GMn at Q2 values of 0.3 to 0.6(GeV/c)2 based on plane wave impulse approximation calculations.

A new method for stable lead isotope extraction from seawater.

PubMed

Zurbrick, Cheryl M; Gallon, Céline; Flegal, A Russell

2013-10-24

A new technique for stable lead (Pb) isotope extraction from seawater is established using Toyopearl AF-Chelate 650M(®) resin (Tosoh Bioscience LLC). This new method is advantageous because it is semi-automated and relatively fast; in addition it introduces a relatively low blank by minimizing the volume of chemicals used in the extraction. Subsequent analyses by HR ICP-MS have a good relative external precision (2σ) of 3.5‰ for (206)Pb/(207)Pb, while analyses by MC-ICP-MS have a better relative external precision of 0.6‰. However, Pb sample concentrations limit MC-ICP-MS analyses to (206)Pb, (207)Pb, and (208)Pb. The method was validated by processing the common Pb isotope reference material NIST SRM-981 and several GEOTRACES intercalibration samples, followed by analyses by HR ICP-MS, all of which showed good agreement with previously reported values. Copyright © 2013 Elsevier B.V. All rights reserved.

Integral bridge abutment-to-approach slab connection.

DOT National Transportation Integrated Search

2008-06-01

The Iowa Department of Transportation has long recognized that approach slab pavements of integral abutment bridges are prone to settlement and cracking, which manifests as the "bump at the end of the bridge". A commonly recommended solution is to in...

CVD diamond pixel detectors for LHC experiments

NASA Astrophysics Data System (ADS)

Wedenig, R.; Adam, W.; Bauer, C.; Berdermann, E.; Bergonzo, P.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; van Eijk, B.; Fallou, A.; Fizzotti, F.; Foulon, F.; Friedl, M.; Gan, K. K.; Gheeraert, E.; Grigoriev, E.; Hallewell, G.; Hall-Wilton, R.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Karl, C.; Kass, R.; Knöpfle, K. T.; Krammer, M.; Logiudice, A.; Lu, R.; Manfredi, P. F.; Manfredotti, C.; Marshall, R. D.; Meier, D.; Mishina, M.; Oh, A.; Pan, L. S.; Palmieri, V. G.; Pernicka, M.; Peitz, A.; Pirollo, S.; Polesello, P.; Pretzl, K.; Procario, M.; Re, V.; Riester, J. L.; Roe, S.; Roff, D.; Rudge, A.; Runolfsson, O.; Russ, J.; Schnetzer, S.; Sciortino, S.; Speziali, V.; Stelzer, H.; Stone, R.; Suter, B.; Tapper, R. J.; Tesarek, R.; Trawick, M.; Trischuk, W.; Vittone, E.; Wagner, A.; Walsh, A. M.; Weilhammer, P.; White, C.; Zeuner, W.; Ziock, H.; Zoeller, M.; Blanquart, L.; Breugnion, P.; Charles, E.; Ciocio, A.; Clemens, J. C.; Dao, K.; Einsweiler, K.; Fasching, D.; Fischer, P.; Joshi, A.; Keil, M.; Klasen, V.; Kleinfelder, S.; Laugier, D.; Meuser, S.; Milgrome, O.; Mouthuy, T.; Richardson, J.; Sinervo, P.; Treis, J.; Wermes, N.; RD42 Collaboration

1999-08-01

This paper reviews the development of CVD diamond pixel detectors. The preparation of the diamond pixel sensors for bump-bonding to the pixel readout electronics for the LHC and the results from beam tests carried out at CERN are described.

The rideability of a deflected bridge approach slab : research project capsule.

DOT National Transportation Integrated Search

2011-08-01

The Localized Roughness Index (LRI) is a parameter that was developed at the Louisiana : Transportation Research Center (LTRC) to quantify localized pavement distresses, such as : pavement surface dips and bumps, concrete slab joint faulting, bridge-...

A Snapshot of the Continuous Emission of the Active Galactic Nucleus in NGC 3783 from Gamma-Ray to Radio Wavelengths

NASA Technical Reports Server (NTRS)

Alloin, D.; Santos-Lleo, M.; Peterson, B. M.; Wamsteker, W.; Altieri, B.; Brinkmann, W.; Clavel, J.; Crenshaw, D. M.; George, I. M.; Glass, I. S.;

Confidence regions for neutrino oscillation parameters from double-Chooz data

NASA Astrophysics Data System (ADS)

Vargas Perez, B.; García-Ravelo, J.; Tun, Dionisio; Garcia Bello, Jorge; Escamilla Roa, Jesús

2018-05-01

In this work, an independent and detailed statistical analysis of the double-Chooz experiment is performed. In order to have a thorough understanding of the implications of the double-Chooz data on both oscillation parameters sin2(2 θ13) and Δ m312, we decided to analyze the data corresponding to the Far detector, with no additional restriction. This differs from previous analyses, which only aim to estimate the mixing angle θ13, without mentioning the effects on Δ m312. By doing this, confidence regions and best fit values are obtained for (sin2(2 θ13),Δ m312). This analysis yields an out-of-order Δ m312 minimum, which has already been mentioned in previous works, and it is corrected with the inclusion of additional restrictions. With such restrictions it is obtained that sin2(2 θ13)=0.08 4-0.028+0.030 and Δ m312=2.44 4-0.215+0.187×10-3 eV2/c4 . Our analysis allows us to study the effects of the so-called "spectral bump" around 5 MeV; it is observed that a variation of this spectral bump may be able to move the Δ m312 best fit value, in such a way that Δ m312 takes the order of magnitude of the MINOS value. In other words, if we allow the variation of the spectral bump, then we may be able to determine both oscillation parameters using Far detector data only, with no further restrictions from other experiments. Finally, and with the intention of understanding the effects of the preliminary Near detector data, we performed two different analyses, aiming to eliminate the effects of the energy bump. As a consequence, it is found that unlike the Far detector analysis, the Near detector data may be able to fully determine both oscillation parameters by itself, resulting in sin2(2 θ13)=0.095 ±0.053 and Δ m312=2.6 3-1.15+0.98×10-3 eV2/c4 . The later analyses represent an improvement with respect to previous works, where additional constraints for Δ m312 were necessary.

Electromigration and thermomigration in lead-free tin-silver-copper and eutectic tin-lead flip chip solder joints

NASA Astrophysics Data System (ADS)

Ou Yang, Fan-Yi

Phase separation and microstructure change of eutectic SnPb and SnAgCu flip chip solder joint were investigated under thermomigration, electromigration, stressmigration and the combination of these effects. Different morphological behaviors under DC and AC electromigration were seen. Phase separation with Pb rich phase migration to the anode was observed when current density is below 1.6 x 104 A/cm2 at 100°C. For some cases, phase separation of Pb-rich phase and Su-rich phase as well as refinement of lamellar microstructure has also been observed. We propose that the refinement is due to recrystallization. On the other hand, time-dependent melting of eutectic SnPb flip chip solder joints has been observed to occur frequently with current density above 1.6 x 104 A/cm 2at 100°C. It has been found that it is due to joule heating of the on-chip Al interconnects. We found that electromigration has especially generated voids at the anode of the Al. This damage has greatly increased the resistance of the Al, which produces the heat needed to melt the solder joint. Owing to the line-to-bump configuration in flip chip solder joints, current crowding occurs when electrons enters into or exits from the solder bump. At the cathode contact, current crowding induced pancake-type void formation was observed widely. Furthermore, at the anode contact, we note that hillock or whisker forms. The cross-sectioned surface in SnPb showed dimple and bulge after electromigration, while that of SnAgCu remained flat. The difference is due to a larger back stress in the SnAgCu, consequently electromigration in SnAgCu is slower than that in SnPb. For thermomigration in eutectic SnPb flip chip solder joints, phase separation of Sn and Pb occurred, with Pb moving to the cold end. Both Sn and Pb have a stepwise concentration profile across solder bump. Refinement of lamellar microstructure was observed, indicating recrystallization. Also, thermomigration in eutectic SnAgCu flip chip solder joint were presented. It seems that vacancy flux plays a dominant role in thermomigration in Pb-free solder bumps; voids formed on the cold end and Sn moved to the hot end.

Generating disease-pertinent treatment vocabularies from MEDLINE citations.

PubMed

Wang, Liqin; Del Fiol, Guilherme; Bray, Bruce E; Haug, Peter J

2017-01-01

Healthcare communities have identified a significant need for disease-specific information. Disease-specific ontologies are useful in assisting the retrieval of disease-relevant information from various sources. However, building these ontologies is labor intensive. Our goal is to develop a system for an automated generation of disease-pertinent concepts from a popular knowledge resource for the building of disease-specific ontologies. A pipeline system was developed with an initial focus of generating disease-specific treatment vocabularies. It was comprised of the components of disease-specific citation retrieval, predication extraction, treatment predication extraction, treatment concept extraction, and relevance ranking. A semantic schema was developed to support the extraction of treatment predications and concepts. Four ranking approaches (i.e., occurrence, interest, degree centrality, and weighted degree centrality) were proposed to measure the relevance of treatment concepts to the disease of interest. We measured the performance of four ranks in terms of the mean precision at the top 100 concepts with five diseases, as well as the precision-recall curves against two reference vocabularies. The performance of the system was also compared to two baseline approaches. The pipeline system achieved a mean precision of 0.80 for the top 100 concepts with the ranking by interest. There were no significant different among the four ranks (p=0.53). However, the pipeline-based system had significantly better performance than the two baselines. The pipeline system can be useful for an automated generation of disease-relevant treatment concepts from the biomedical literature. Copyright © 2016 Elsevier Inc. All rights reserved.

Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry.

PubMed

Eichhold, Thomas H; McCauley-Myers, David L; Khambe, Deepa A; Thompson, Gary A; Hoke, Steven H

2007-01-17

A method for the simultaneous determination of dextromethorphan (DEX), dextrorphan (DET), and guaifenesin (GG) in human plasma was developed, validated, and applied to determine plasma concentrations of these compounds in samples from six clinical pharmacokinetic (PK) studies. Semi-automated liquid handling systems were used to perform the majority of the sample manipulation including liquid/liquid extraction (LLE) of the analytes from human plasma. Stable-isotope-labeled analogues were utilized as internal standards (ISTDs) for each analyte to facilitate accurate and precise quantification. Extracts were analyzed using gradient liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Use of semi-automated LLE with LC-MS/MS proved to be a very rugged and reliable approach for analysis of more than 6200 clinical study samples. The lower limit of quantification was validated at 0.010, 0.010, and 1.0 ng/mL of plasma for DEX, DET, and GG, respectively. Accuracy and precision of quality control (QC) samples for all three analytes met FDA Guidance criteria of +/-15% for average QC accuracy with coefficients of variation less than 15%. Data from the thorough evaluation of the method during development, validation, and application are presented to characterize selectivity, linearity, over-range sample analysis, accuracy, precision, autosampler carry-over, ruggedness, extraction efficiency, ionization suppression, and stability. Pharmacokinetic data are also provided to illustrate improvements in systemic drug and metabolite concentration-time profiles that were achieved by formulation optimization.

Precise measurement of instantaneous volume of eccrine sweat gland in mental sweating by optical coherence tomography

NASA Astrophysics Data System (ADS)

Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

2015-03-01

We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). We propose a method for extraction of the target eccrine sweat gland by use of the connected component extraction process and the adaptive threshold method, where the en-face OCT images are constructed by the SS-OCT. Furthermore, we demonstrate precise measurement of instantaneous volume of the sweat gland in response to the external stimulus. The dynamic change of instantaneous volume of eccrine sweat gland in mental sweating is performed by this method during the period of 300 sec with the frame intervals of 3.23 sec.

The Science and Art of Eyebrow Transplantation by Follicular Unit Extraction

PubMed Central

Gupta, Jyoti; Kumar, Amrendra; Chouhan, Kavish; Ariganesh, C; Nandal, Vinay

2017-01-01

Eyebrows constitute a very important and prominent feature of the face. With growing information, eyebrow transplant has become a popular procedure. However, though it is a small area it requires a lot of precision and knowledge regarding anatomy, designing of brows, extraction and implantation technique. This article gives a comprehensive view regarding eyebrow transplant with special emphasis on follicular unit extraction technique, which has become the most popular technique. PMID:28852290

Determination of copper by isotopic dilution.

PubMed

Faquim, E S; Munita, C S

1994-01-01

A rapid and selective method was used for the determination of copper by isotopic dilution employing substoichiometric extraction with dithizone in carbon tetrachloride. The appropriate pH range for the substoichiometric extraction was 2-7. In the analysis, even a large excess of elements forming extractable complexes with dithizone does not interfere. The accuracy and precision of the method were evaluated. The method has been applied to analysis of reference materials, wheat flour, wine, and beer.

Vertical Corner Feature Based Precise Vehicle Localization Using 3D LIDAR in Urban Area

PubMed Central

Im, Jun-Hyuck; Im, Sung-Hyuck; Jee, Gyu-In

2016-01-01

Tall buildings are concentrated in urban areas. The outer walls of buildings are vertically erected to the ground and almost flat. Therefore, the vertical corners that meet the vertical planes are present everywhere in urban areas. These corners act as convenient landmarks, which can be extracted by using the light detection and ranging (LIDAR) sensor. A vertical corner feature based precise vehicle localization method is proposed in this paper and implemented using 3D LIDAR (Velodyne HDL-32E). The vehicle motion is predicted by accumulating the pose increment output from the iterative closest point (ICP) algorithm based on the geometric relations between the scan data of the 3D LIDAR. The vertical corner is extracted using the proposed corner extraction method. The vehicle position is then corrected by matching the prebuilt corner map with the extracted corner. The experiment was carried out in the Gangnam area of Seoul, South Korea. In the experimental results, the maximum horizontal position error is about 0.46 m and the 2D Root Mean Square (RMS) horizontal error is about 0.138 m. PMID:27517936

Laboratory testing of precast paving notch system.

DOT National Transportation Integrated Search

2008-02-01

Bridge approach pavement settlement and the resulting formation of bumps at the end : of bridges is a recurring problem on a number of Iowa bridges. One of the contributing : factors in this settlement is failure of the bridge paving notch. A p...

Tribology: Diamonds are forever - or are they?

NASA Astrophysics Data System (ADS)

Fineberg, Jay

2011-01-01

The friction and wear of materials is part of our everyday experience, and yet these processes are not well understood. The example of diamond highlights wear processes that result from bumping atoms, showing that the devil is indeed in the details.

Impact of a smoothness incentive.

DOT National Transportation Integrated Search

2006-01-01

Smoothness, the absence of bumps and dips in the riding surface of a pavement, improves the quality of the ride and is believed to prolong the life of the pavement. This research addressed the impact of potential pay adjustments for smoothness on mai...

Educational Computing Course. [SITE 2001 Section].

ERIC Educational Resources Information Center

Bump, Wren, Ed.

This document contains the following papers on the educational computing course from the SITE (Society for Information Technology & Teacher Education) 2001 conference: "Using a Flexible Format To Create a Constructivist Learning Environment in the Educational Computing Course" (Wren M. Bump); "Technological Diversity: Managing…

Betwixt and Between: Academic Women in Transition

ERIC Educational Resources Information Center

Bosetti, Lynn; Kawalilak, Colleen; Patterson, Peggy

2008-01-01

University culture is increasingly being influenced by globalization, competition, the commercialization of research, and external demands for accountability. Corporate managerial practices that value individualism and productivity bump up against more democratic and collaborative practices inherent in the traditional academic culture and…

Field demonstration of new bridge approach slab designs and performance.

DOT National Transportation Integrated Search

2014-06-01

The Louisiana Department of Transportation and Development (DOTD) has initiated a major effort to minimize the bridge end bump problem associated : with differential settlement. As a result, a new design for the approach slab was proposed, which requ...

Vortices Bump into a Hot Spot in Jupiter Atmosphere

NASA Image and Video Library

2013-03-14

In this series of images from NASA Cassini spacecraft, a dark, rectangular hot spot interacts with a line of vortices that approaches from on the upper-right side. The interaction distorts the shape of the hot spot, leaving it diminished.

First Aid: Falls

MedlinePlus

... Folleto de instructiones: Caídas (Falls) With all the running, climbing, and exploring kids do, it's no surprise that falls are common. Although many result in mild bumps, cuts, and bruises, some can cause serious injuries that need immediate medical attention. What to Do ...

Inadequacy, Impurity and Infidelity; Modifying the Modified Brendel Alpha-Cellulose Extraction Method for Resinous Woods in Stable Isotope Dendroclimatology

NASA Astrophysics Data System (ADS)

Brookman, T. H.; Whittaker, T. E.; King, P. L.; Horton, T. W.

2011-12-01

Stable isotope dendroclimatology is a burgeoning field in palaeoclimate science due to its unique potential to contribute (sub)annually resolved climate records, over millennial timescales, to the terrestrial palaeoclimate record. Until recently the time intensive methods precluded long-term climate reconstructions. Advances in continuous-flow mass spectrometry and isolation methods for α-cellulose (ideal for palaeoclimate studies as, unlike other wood components, it retains its initial isotopic composition) have made long-term, calendar dated palaeoclimate reconstructions a viable proposition. The Modified Brendel (mBrendel) α-cellulose extraction method is a fast, cost-effective way of preparing whole-wood samples for stable oxygen and carbon isotope analysis. However, resinous woods often yield incompletely processed α-cellulose using the standard mBrendel approach. As climate signals may be recorded by small (<1%) isotopic shifts it is important to investigate if incomplete processing affects the accuracy and precision of tree-ring isotopic records. In an effort to address this methodological issue, we investigated three highly resinous woods: kauri (Agathis australis), ponderosa pine (Pinus ponderosa) and huon pine (Lagarastrobus franklinii). Samples of each species were treated with 16 iterations of the mBrendel, varying reaction temperature, time and reagent volumes. Products were investigated using microscopic and bulk transmission Fourier Transform infrared spectroscopy (FITR) to reveal variations in the level of processing; poorly-digested fibres display a peak at 1520cm-1 suggesting residual lignin and a peak at ~1600cm-1 in some samples suggests retained resin. Despite the different levels of purity, replicate analyses of samples processed by high temperature digestion yielded consistent δ18O within and between experiments. All α-cellulose samples were 5-7% enriched compared to the whole-wood, suggesting that even incomplete processing at high temperature can provide acceptable δ18O analytical external precision. For kauri, short, lower temperature extractions produced α-cellulose with δ18O consistently ~1% lower than longer, higher temperature kauri experiments. These findings suggest that temperature and time are significant variables that influence the analytical precision of α-cellulose stable isotope analysis and that resinous hardwoods (e.g. kauri) may require longer and/or hotter digestions than softwoods. The effects of mBrendel variants on the carbon isotope ratio precision of α-cellulose extracts will also be presented. Our findings indicate that the standard mBrendel α-cellulose extraction method may not fully remove lignins and resins depending on the type of wood being analysed. Residual impurities can decrease analytical precision and accuracy. Fortunately, FTIR analysis prior to isotopic analysis is a relatively fast and cost effective way to determine α-cellulose extract purity, ultimately improving the data quality, accuracy and utility of tree-ring based stable isotopic climate records.

Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry.

PubMed

Xue, Y J; Pursley, Janice; Arnold, Mark

2007-04-11

BMS-299897 is a gamma-secretase inhibitor that is being developed for the treatment of Alzheimer's disease. Liquid-liquid extraction (LLE), chromatographic/tandem mass spectrometry (LC/MS/MS) methods have been developed and validated for the quantitation of BMS-299897 in human plasma and cerebrospinal fluid (CSF). Both methods utilized (13)C6-BMS-299897, the stable label isotope analog, as the internal standard. For the human plasma extraction method, two incubation steps were required after the addition of 5 mM ammonium acetate and the internal standard in acetonitrile to release the analyte bound to proteins prior to LLE with toluene. For the human CSF extraction method, after the addition of 0.5 N HCl and the internal standard, CSF samples were extracted with toluene and no incubation was required. The organic layers obtained from both extraction methods were removed and evaporated to dryness. The residues were reconstituted and injected into the LC/MS/MS system. Chromatographic separation was achieved isocratically on a MetaChem C18 Hypersil BDS column (2.0 mm x 50 mm, 3 microm). The mobile phase contained 10 mM ammonium acetate pH 5 and acetonitrile. Detection was by negative ion electrospray tandem mass spectrometry. The standard curves ranged from 1 to 1000 ng/ml for human plasma and 0.25-100 ng/ml for human CSF. Both standard curves were fitted to a 1/x weighted quadratic regression model. For both methods, the intra-assay precision was within 8.2% CV, the inter-assay precision was within 5.4% CV, and assay accuracy was within +/-7.4% of the nominal values. The validation and sample analysis results demonstrated that both methods had acceptable precision and accuracy across the calibration ranges.

Simultaneous extraction of polycyclic aromatic hydrocarbons through the complete dissolution of solid biological samples in sodium hydroxide/urea/thiourea aqueous solution.

PubMed

Mohammad, Sedigheh Ale; Ghanemi, Kamal; Larki, Arash

2016-12-09

In order to precisely and simultaneously extract polycyclic aromatic hydrocarbons (PAHs) for measurement using a high performance liquid chromatography-fluorescence detector (HPLC-FL), a novel sample preparation method was developed. This method is based on the complete and fast dissolution of biological samples in a new non-alcoholic alkaline medium. A solution composed of NaOH/urea/thiourea at an optimized ratio was used for complete dissolution of approximately 0.25g dried fish samples within 20min. The proposed method was conducted at 10°C and under atmospheric pressure to obtain a stable and highly homogeneous solution, without the need for microwaves or any other apparatus. This process operates at considerably lower temperature than conventional methods and provides an opportunity to simultaneously extract the target analytes from their matrices by adding the extracting solvent in the initial steps of the dissolution; this process greatly reduced the time of analysis and the loss of analytes via vaporization. Several key parameters were identified and their effects on precision and extraction recoveries were investigated. Linearity over a calibration range of 1.0-100 and 2.5-100ngg -1 was achieved, with high coefficients of determination (r 2 ) ranging between 0.9987 and 0.9998. Based on relative standard deviations (n=5), the intra-day and inter-day precisions of the spiked PAHs were found to be better than 3.1% and 3.2%, respectively, at a concentration level of 25ngg -1 . The recoveries of PAH from spiked marine fish tissues and shrimp samples were in the range of 90.6%-100.4%. The spiked samples were also treated with the alcoholic alkaline and Soxhlet extraction methods in order to provide a comparison. Copyright © 2016 Elsevier B.V. All rights reserved.

Ionic liquids intercalated in montmorillonite as the sorptive phase for the extraction of low-polarity organic compounds from water by rotating-disk sorptive extraction.

PubMed

Fiscal-Ladino, Jhon A; Obando-Ceballos, Mónica; Rosero-Moreano, Milton; Montaño, Diego F; Cardona, Wilson; Giraldo, Luis F; Richter, Pablo

2017-02-08

Montmorillonite (MMT) clays were modified by the intercalation into their galleries of ionic liquids (IL) based on imidazolium quaternary ammonium salts. This new eco-materials exhibited good features for use as a sorptive phase in the extraction of low-polarity analytes from aqueous samples. Spectroscopic analyses of the modified clays were conducted and revealed an increase in the basal spacing and a shifting of the reflection plane towards lower values as a consequence of the effective intercalation of organic cations into the MMT structure. The novel sorbent developed herein was assayed as the sorptive phase in rotating-disk sorptive extraction (RDSE), using polychlorinated biphenyls (PCBs), representative of low-polarity pollutants, as model analytes. The final determination was made by gas chromatography with electron capture detection. Among the synthetized sorptive phases, the selected system for analytical purposes consisted of MMT modified with the 1-hexadecyl-3-methylimidazolium bromide (HDMIM-Br) IL. Satisfactory analytical features were achieved using a sample volume of 5 mL: the relative recoveries from a wastewater sample were higher than 80%, the detection limits were between 3 ng L -1 and 43 ng L -1 , the precision (within-run precision) expressed as the relative standard deviation ranged from 2% to 24%, and the enrichment factors ranged between 18 and 28. Using RDSE, the extraction efficiency achieved for the selected MMT-HDMIM-Br phase was compared with other commercial solid phases/supports, such as polypropylene, polypropylene with 1-octanol (as a supported liquid membrane), octadecyl (C18) and octyl (C8), and showed the highest response for all the studied analytes. Under the optimized extraction conditions, this new device was applied in the analysis of the influent of a wastewater treatment plant in Santiago (Chile), demonstrating its applicability through the good recoveries and precision achieved with real samples. Copyright © 2016 Elsevier B.V. All rights reserved.

Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS).

PubMed

Xu, Rong; Wang, Quanqiu

2014-02-01

Targeted drugs dramatically improve the treatment outcomes in cancer patients; however, these innovative drugs are often associated with unexpectedly high cardiovascular toxicity. Currently, cardiovascular safety represents both a challenging issue for drug developers, regulators, researchers, and clinicians and a concern for patients. While FDA drug labels have captured many of these events, spontaneous reporting systems are a main source for post-marketing drug safety surveillance in 'real-world' (outside of clinical trials) cancer patients. In this study, we present approaches to extracting, prioritizing, filtering, and confirming cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS). The dataset includes records of 4,285,097 patients from FAERS. We first extracted drug-cardiovascular event (drug-CV) pairs from FAERS through named entity recognition and mapping processes. We then compared six ranking algorithms in prioritizing true positive signals among extracted pairs using known drug-CV pairs derived from FDA drug labels. We also developed three filtering algorithms to further improve precision. Finally, we manually validated extracted drug-CV pairs using 21 million published MEDLINE records. We extracted a total of 11,173 drug-CV pairs from FAERS. We showed that ranking by frequency is significantly more effective than by the five standard signal detection methods (246% improvement in precision for top-ranked pairs). The filtering algorithm we developed further improved overall precision by 91.3%. By manual curation using literature evidence, we show that about 51.9% of the 617 drug-CV pairs that appeared in both FAERS and MEDLINE sentences are true positives. In addition, 80.6% of these positive pairs have not been captured by FDA drug labeling. The unique drug-CV association dataset that we created based on FAERS could facilitate our understanding and prediction of cardiotoxic events associated with targeted cancer drugs. Copyright © 2013 Elsevier Inc. All rights reserved.

Automation of ⁹⁹Tc extraction by LOV prior ICP-MS detection: application to environmental samples.

PubMed

Rodríguez, Rogelio; Leal, Luz; Miranda, Silvia; Ferrer, Laura; Avivar, Jessica; García, Ariel; Cerdà, Víctor

2015-02-01

A new, fast, automated and inexpensive sample pre-treatment method for (99)Tc determination by inductively coupled plasma-mass spectrometry (ICP-MS) detection is presented. The miniaturized approach is based on a lab-on-valve (LOV) system, allowing automatic separation and preconcentration of (99)Tc. Selectivity is provided by the solid phase extraction system used (TEVA resin) which retains selectively pertechnetate ion in diluted nitric acid solution. The proposed system has some advantages such as minimization of sample handling, reduction of reagents volume, improvement of intermediate precision and sample throughput, offering a significant decrease of both time and cost per analysis in comparison to other flow techniques and batch methods. The proposed LOV system has been successfully applied to different samples of environmental interest (water and soil) with satisfactory recoveries, between 94% and 98%. The detection limit (LOD) of the developed method is 0.005 ng. The high durability of the resin and its low amount (32 mg), its good intermediate precision (RSD 3.8%) and repeatability (RSD 2%) and its high extraction frequency (up to 5 h(-1)) makes this method an inexpensive, high precision and fast tool for monitoring (99)Tc in environmental samples. Copyright © 2014 Elsevier B.V. All rights reserved.

Identification of cultivated land using remote sensing images based on object-oriented artificial bee colony algorithm

NASA Astrophysics Data System (ADS)

Li, Nan; Zhu, Xiufang

2017-04-01

Cultivated land resources is the key to ensure food security. Timely and accurate access to cultivated land information is conducive to a scientific planning of food production and management policies. The GaoFen 1 (GF-1) images have high spatial resolution and abundant texture information and thus can be used to identify fragmentized cultivated land. In this paper, an object-oriented artificial bee colony algorithm was proposed for extracting cultivated land from GF-1 images. Firstly, the GF-1 image was segmented by eCognition software and some samples from the segments were manually identified into 2 types (cultivated land and non-cultivated land). Secondly, the artificial bee colony (ABC) algorithm was used to search for classification rules based on the spectral and texture information extracted from the image objects. Finally, the extracted classification rules were used to identify the cultivated land area on the image. The experiment was carried out in Hongze area, Jiangsu Province using wide field-of-view sensor on the GF-1 satellite image. The total precision of classification result was 94.95%, and the precision of cultivated land was 92.85%. The results show that the object-oriented ABC algorithm can overcome the defect of insufficient spectral information in GF-1 images and obtain high precision in cultivated identification.

Process for preparing energetic materials

DOEpatents

Simpson, Randall L [Livermore, CA; Lee, Ronald S [Livermore, CA; Tillotson, Thomas M [Tracy, CA; Hrubesh, Lawrence W [Pleasanton, CA; Swansiger, Rosalind W [Livermore, CA; Fox, Glenn A [Livermore, CA

2011-12-13

Sol-gel chemistry is used for the preparation of energetic materials (explosives, propellants and pyrotechnics) with improved homogeneity, and/or which can be cast to near-net shape, and/or made into precision molding powders. The sol-gel method is a synthetic chemical process where reactive monomers are mixed into a solution, polymerization occurs leading to a highly cross-linked three dimensional solid network resulting in a gel. The energetic materials can be incorporated during the formation of the solution or during the gel stage of the process. The composition, pore, and primary particle sizes, gel time, surface areas, and density may be tailored and controlled by the solution chemistry. The gel is then dried using supercritical extraction to produce a highly porous low density aerogel or by controlled slow evaporation to produce a xerogel. Applying stress during the extraction phase can result in high density materials. Thus, the sol-gel method can be used for precision detonator explosive manufacturing as well as producing precision explosives, propellants, and pyrotechnics, along with high power composite energetic materials.

Sol-Gel Manufactured Energetic Materials

DOEpatents

Simpson, Randall L.; Lee, Ronald S.; Tillotson, Thomas M.; Hrubesh, Lawrence W.; Swansiger, Rosalind W.; Fox, Glenn A.

2005-05-17

Sol-gel chemistry is used for the preparation of energetic materials (explosives, propellants and pyrotechnics) with improved homogeneity, and/or which can be cast to near-net shape, and/or made into precision molding powders. The sol-gel method is a synthetic chemical process where reactive monomers are mixed into a solution, polymerization occurs leading to a highly cross-linked three dimensional solid network resulting in a gel. The energetic materials can be incorporated during the formation of the solution or during the gel stage of the process. The composition, pore, and primary particle sizes, gel time, surface areas, and density may be tailored and controlled by the solution chemistry. The gel is then dried using supercritical extraction to produce a highly porous low density aerogel or by controlled slow evaporation to produce a xerogel. Applying stress during the extraction phase can result in high density materials. Thus, the sol-gel method can be used for precision detonator explosive manufacturing as well as producing precision explosives, propellants, and pyrotechnics, along with high power composite energetic materials.

Sol-gel manufactured energetic materials

DOEpatents

Simpson, Randall L.; Lee, Ronald S.; Tillotson, Thomas M.; Hrubesh, Lawrence W.; Swansiger, Rosalind W.; Fox, Glenn A.

2003-12-23

Sol-gel chemistry is used for the preparation of energetic materials (explosives, propellants and pyrotechnics) with improved homogeneity, and/or which can be cast to near-net shape, and/or made into precision molding powders. The sol-gel method is a synthetic chemical process where reactive monomers are mixed into a solution, polymerization occurs leading to a highly cross-linked three dimensional solid network resulting in a gel. The energetic materials can be incorporated during the formation of the solution or during the gel stage of the process. The composition, pore, and primary particle sizes, gel time, surface areas, and density may be tailored and controlled by the solution chemistry. The gel is then dried using supercritical extraction to produce a highly porous low density aerogel or by controlled slow evaporation to produce a xerogel. Applying stress during the extraction phase can result in high density materials. Thus, the sol-gel method can be used for precision detonator explosive manufacturing as well as producing precision explosives, propellants, and pyrotechnics, along with high power composite energetic materials.

PrecisePrimer: an easy-to-use web server for designing PCR primers for DNA library cloning and DNA shuffling.

PubMed

Pauthenier, Cyrille; Faulon, Jean-Loup

2014-07-01

PrecisePrimer is a web-based primer design software made to assist experimentalists in any repetitive primer design task such as preparing, cloning and shuffling DNA libraries. Unlike other popular primer design tools, it is conceived to generate primer libraries with popular PCR polymerase buffers proposed as pre-set options. PrecisePrimer is also meant to design primers in batches, such as for DNA libraries creation of DNA shuffling experiments and to have the simplest interface possible. It integrates the most up-to-date melting temperature algorithms validated with experimental data, and cross validated with other computational tools. We generated a library of primers for the extraction and cloning of 61 genes from yeast DNA genomic extract using default parameters. All primer pairs efficiently amplified their target without any optimization of the PCR conditions. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Automated encoding of clinical documents based on natural language processing.

PubMed

Friedman, Carol; Shagina, Lyudmila; Lussier, Yves; Hripcsak, George

2004-01-01

The aim of this study was to develop a method based on natural language processing (NLP) that automatically maps an entire clinical document to codes with modifiers and to quantitatively evaluate the method. An existing NLP system, MedLEE, was adapted to automatically generate codes. The method involves matching of structured output generated by MedLEE consisting of findings and modifiers to obtain the most specific code. Recall and precision applied to Unified Medical Language System (UMLS) coding were evaluated in two separate studies. Recall was measured using a test set of 150 randomly selected sentences, which were processed using MedLEE. Results were compared with a reference standard determined manually by seven experts. Precision was measured using a second test set of 150 randomly selected sentences from which UMLS codes were automatically generated by the method and then validated by experts. Recall of the system for UMLS coding of all terms was .77 (95% CI.72-.81), and for coding terms that had corresponding UMLS codes recall was .83 (.79-.87). Recall of the system for extracting all terms was .84 (.81-.88). Recall of the experts ranged from .69 to .91 for extracting terms. The precision of the system was .89 (.87-.91), and precision of the experts ranged from .61 to .91. Extraction of relevant clinical information and UMLS coding were accomplished using a method based on NLP. The method appeared to be comparable to or better than six experts. The advantage of the method is that it maps text to codes along with other related information, rendering the coded output suitable for effective retrieval.

Ultrasound-Assisted Extraction of Stilbenes from Grape Canes.

PubMed

Piñeiro, Zulema; Marrufo-Curtido, Almudena; Serrano, Maria Jose; Palma, Miguel

2016-06-16

An analytical ultrasound-assisted extraction (UAE) method has been optimized and validated for the rapid extraction of stilbenes from grape canes. The influence of sample pre-treatment (oven or freeze-drying) and several extraction variables (solvent, sample-solvent ratio and extraction time between others) on the extraction process were analyzed. The new method allowed the main stilbenes in grape canes to be extracted in just 10 min, with an extraction temperature of 75 °C and 60% ethanol in water as the extraction solvent. Validation of the extraction method was based on analytical properties. The resulting RSDs (n = 5) for interday/intraday precision were less than 10%. Furthermore, the method was successfully applied in the analysis of 20 different grape cane samples. The result showed that grape cane byproducts are potentially sources of bioactive compounds of interest for pharmaceutical and food industries.

Binder-Grade Bumping and High Binder Content to Improve Performance of RAP-RAS Mixtures : Final Report : SPR 797

DOT National Transportation Integrated Search

2018-01-01

Connected vehicle mobility applications are commonly referred to as dynamic mobility applications (DMAs). DMAs seek to fully leverage frequently collected and rapidly disseminated multi-source data gathered from connected travelers, vehicles, and inf...

Red in the Face: Understanding Rosacea

MedlinePlus

... sometimes-painful bumps. Inflamed eyes or eyelids. Swollen, red, bumpy nose, especially in men. Links Fast Facts about Rosacea Questions and Answers about Rosacea NIH Office of Communications and Public Liaison Building 31, Room 5B52 Bethesda, MD 20892-2094 nihnewsinhealth@od.nih. ...

Alternative and cost-effective bridge approach slabs.

DOT National Transportation Integrated Search

2010-10-01

The primary objectives of the proposed project are to investigate the causes for any bumps at the end of the bridge approach slab : and to develop remedial measures or alternative designs for a replacement. It is clear that the problem stems from geo...

5 CFR 351.701 - Assignment involving displacement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Assignment involving displacement. 351.701 Section 351.701 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.701 Assignment involving displacement. (a...

5 CFR 351.701 - Assignment involving displacement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Assignment involving displacement. 351.701 Section 351.701 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.701 Assignment involving displacement. (a...

5 CFR 351.701 - Assignment involving displacement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Assignment involving displacement. 351.701 Section 351.701 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.701 Assignment involving displacement. (a...

5 CFR 351.701 - Assignment involving displacement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Assignment involving displacement. 351.701 Section 351.701 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.701 Assignment involving displacement. (a...

5 CFR 351.701 - Assignment involving displacement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Assignment involving displacement. 351.701 Section 351.701 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.701 Assignment involving displacement. (a...

Applied approach slab settlement research, design/construction : final report.

DOT National Transportation Integrated Search

2013-08-01

Approach embankment settlement is a pervasive problem in Oklahoma and many other states. The bump and/or abrupt slope change poses a danger to traffic and can cause increased dynamic loads on the bridge. Frequent and costly maintenance may be needed ...

Identification and evaluation of pavement-bridge interface ride quality improvement and corrective strategies.

DOT National Transportation Integrated Search

2011-01-01

Bridge owners have long recognized that the approach pavement at bridges is prone to exhibiting both settlement and : cracking, which manifest as the bump at the end of the bridge. This deterioration requires considerable on-going : maintenance...

FHWA LTPP Guidelines for Measuring Bridge Approach Transitions Using Inertial Profilers

DOT National Transportation Integrated Search

2016-12-01

The bump at the end of the bridge has long been studied for highways and railways, yet experts from across the transportation industry continue to identify it as one of the most prevalent substructure factors affecting bridge performance. Often, ride...

Comparison of solvent extraction and solid-phase extraction for the determination of polychlorinated biphenyls in transformer oil.

PubMed

Mahindrakar, A N; Chandra, S; Shinde, L P

2014-01-01

Solid-phase extraction (SPE) of nine polychlorinated biphenyls (PCBs) from transformer oil samples was evaluated using octadecyl (CI8)-bonded porous silica. The efficiency of SPE of these PCBs was compared with those obtained by solvent extraction with DMSO and hexane. Average recoveries exceeding 95% for these PCBs were obtained via the SPE method using small cartridges containing 100mg of 40 pm CI8-bonded porous silica. The average recovery by solvent extraction with DMSO and hexane exceeded 83%. It was concluded that the recoveries and precision for the solvent extraction of PCBs were poorer than those for the SPE. Copyright © 2013 Elsevier Ltd. All rights reserved.

Determination of acetanilide herbicides in cereal crops using accelerated solvent extraction, solid-phase extraction and gas chromatography-electron capture detector.

PubMed

Zhang, Yaping; Yang, Jun; Shi, Ronghua; Su, Qingde; Yao, Li; Li, Panpan

2011-07-01

A method was developed to determine eight acetanilide herbicides from cereal crops based on accelerated solvent extraction (ASE) and solid-phase extraction (SPE) followed by gas chromatography-electron capture detector (GC-ECD) analysis. During the ASE process, the effect of four parameters (temperature, static time, static cycles and solvent) on the extraction efficiency was considered and compared with shake-flask extraction method. After extraction with ASE, four SPE tubes (graphitic carbon black/primary secondary amine (GCB/PSA), GCB, Florisil and alumina-N) were assayed for comparison to obtain the best clean-up efficiency. The results show that GCB/PSA cartridge gave the best recoveries and cleanest chromatograms. The analytical process was validated by the analysis of spiked blank samples. Performance characteristics such as linearity, limit of detection (LOD), limit of quantitation (LOQ), precision and recovery were studied. At 0.05 mg/kg spiked level, recoveries and precision values for rice, wheat and maize were 82.3-115.8 and 1.1-13.6%, respectively. For all the herbicides, LOD and LOQ ranged from 0.8 to 1.7 μg/kg and from 2.4 to 5.3 μg/kg, respectively. The proposed analytical methodology was applied for the analysis of the targets in samples; only three herbicides, propyzamid, metolachlor and diflufenican, were detected in two samples. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Performance of a 512 x 512 Gated CMOS Imager with a 250 ps Exposure Time

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teruya, A T; Moody, J D; Hsing, W W

2012-10-01

We describe the performance of a 512x512 gated CMOS read out integrated circuit (ROIC) with a 250 ps exposure time. A low-skew, H-tree trigger distribution system is used to locally generate individual pixel gates in each 8x8 neighborhood of the ROIC. The temporal width of the gate is voltage controlled and user selectable via a precision potentiometer. The gating implementation was first validated in optical tests of a 64x64 pixel prototype ROIC developed as a proof-of-concept during the early phases of the development program. The layout of the H-Tree addresses each quadrant of the ROIC independently and admits operation ofmore » the ROIC in two modes. If “common mode” triggering is used, the camera provides a single 512x512 image. If independent triggers are used, the camera can provide up to four 256x256 images with a frame separation set by the trigger intervals. The ROIC design includes small (sub-pixel) optical photodiode structures to allow test and characterization of the ROIC using optical sources prior to bump bonding. Reported test results were obtained using short pulse, second harmonic Ti:Sapphire laser systems operating at λ~ 400 nm at sub-ps pulse widths.« less

The effect of intermetallic compound morphology on Cu diffusion in Sn-Ag and Sn-Pb solder bump on the Ni/Cu Under-bump metallization

NASA Astrophysics Data System (ADS)

Jang, Guh-Yaw; Duh, Jenq-Gong

2005-01-01

The eutectic Sn-Ag solder alloy is one of the candidates for the Pb-free solder, and Sn-Pb solder alloys are still widely used in today’s electronic packages. In this tudy, the interfacial reaction in the eutectic Sn-Ag and Sn-Pb solder joints was investigated with an assembly of a solder/Ni/Cu/Ti/Si3N4/Si multilayer structures. In the Sn-3.5Ag solder joints reflowed at 260°C, only the (Ni1-x,Cux)3Sn4 intermetallic compound (IMC) formed at the solder/Ni interface. For the Sn-37Pb solder reflowed at 225°C for one to ten cycles, only the (Ni1-x,Cux)3Sn4 IMC formed between the solder and the Ni/Cu under-bump metallization (UBM). Nevertheless, the (Cu1-y,Niy)6Sn5 IMC was observed in joints reflowed at 245°C after five cycles and at 265°C after three cycles. With the aid of microstructure evolution, quantitative analysis, and elemental distribution between the solder and Ni/Cu UBM, it was revealed that Cu content in the solder near the solder/IMC interface played an important role in the formation of the (Cu1-y,Niy)6Sn5 IMC. In addition, the diffusion behavior of Cu in eutectic Sn-Ag and Sn-Pb solders with the Ni/Cu UBM were probed and discussed. The atomic flux of Cu diffused through Ni was evaluated by detailed quantitative analysis in an electron probe microanalyzer (EPMA). During reflow, the atomic flux of Cu was on the order of 1016-1017 atoms/cm2sec in both the eutectic Sn-Ag and Sn-Pb systems.

Artificial plasma cusp generated by upper hybrid instabilities in HF heating experiments at HAARP

NASA Astrophysics Data System (ADS)

Kuo, Spencer; Snyder, Arnold

2013-05-01

High Frequency Active Auroral Research Program digisonde was operated in a fast mode to record ionospheric modifications by the HF heating wave. With the O mode heater of 3.2 MHz turned on for 2 min, significant virtual height spread was observed in the heater off ionograms, acquired beginning the moment the heater turned off. Moreover, there is a noticeable bump in the virtual height spread of the ionogram trace that appears next to the plasma frequency (~ 2.88 MHz) of the upper hybrid resonance layer of the HF heating wave. The enhanced spread and the bump disappear in the subsequent heater off ionograms recorded 1 min later. The height distribution of the ionosphere in the spread situation indicates that both electron density and temperature increases exceed 10% over a large altitude region (> 30 km) from below to above the upper hybrid resonance layer. This "mini cusp" (bump) is similar to the cusp occurring in daytime ionograms at the F1-F2 layer transition, indicating that there is a small ledge in the density profile reminiscent of F1-F2 layer transitions. Two parametric processes exciting upper hybrid waves as the sidebands by the HF heating waves are studied. Field-aligned purely growing mode and lower hybrid wave are the respective decay modes. The excited upper hybrid and lower hybrid waves introduce the anomalous electron heating which results in the ionization enhancement and localized density ledge. The large-scale density irregularities formed in the heat flow, together with the density irregularities formed through the parametric instability, give rise to the enhanced virtual height spread. The results of upper hybrid instability analysis are also applied to explain the descending feature in the development of the artificial ionization layers observed in electron cyclotron harmonic resonance heating experiments.

Global view of the E region irregularity and convection velocities in the high-latitude Southern Hemisphere

NASA Astrophysics Data System (ADS)

Forsythe, Victoriya V.; Makarevich, Roman A.

2017-02-01

Occurrence of the E region plasma irregularities is investigated using two Super Dual Auroral Radar Network (SuperDARN) South Pole (SPS) and Zhongshan (ZHO) radars that sample the same magnetic latitude deep within the high-latitude plasma convection pattern but from two opposite directions. It is shown that the SPS and ZHO velocity distributions and their variations with the magnetic local time are different, with each distribution being asymmetric; i.e., a particular velocity polarity is predominant. This asymmetry in the E region velocity distribution is associated with the bump-on-tail of the distribution near the nominal ion acoustic speed Cs that is most likely due to the Farley-Buneman instability (FBI) echoes or an inflection point of the distribution below nominal Cs that is most likely due to the gradient drift instability echoes. In contrast, the distribution of the convection velocity component was found to be symmetric, i.e., with no bump-on-tail or an inflection point, but with a bias (i.e., uniform shift) toward a particular polarity. It is demonstrated that the asymmetry in the convection pattern between the eastward and westward zonal components is unexpectedly strong, with the westward zonal component being predominant, especially at lower latitudes, while also exhibiting a strong interplanetary magnetic field By dependence. The observations are consistent with the notion that the asymmetry in the E region velocity distribution is highly sensitive to the bias in the convection component caused by the zonal convection component asymmetry and that the bump-on-tail or inflection point features may also depend on the irregularity height and the presence of strong density gradients modifying the FBI threshold value.

Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

NASA Astrophysics Data System (ADS)

Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

2011-01-01

The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

Late Time Multi-wavelength Observations of Swift J1644+5734: A Luminous Optical/IR Bump and Quiescent X-Ray Emission

NASA Astrophysics Data System (ADS)

Levan, A. J.; Tanvir, N. R.; Brown, G. C.; Metzger, B. D.; Page, K. L.; Cenko, S. B.; O'Brien, P. T.; Lyman, J. D.; Wiersema, K.; Stanway, E. R.; Fruchter, A. S.; Perley, D. A.; Bloom, J. S.

2016-03-01

We present late time multi-wavelength observations of Swift J1644+57, suggested to be a relativistic tidal disruption flare (TDF). Our observations extend to >4 years from discovery and show that 1.4 years after outburst the relativistic jet switched off on a timescale less than tens of days, corresponding to a power-law decay faster than t-70. Beyond this point weak X-rays continue to be detected at an approximately constant luminosity of LX ˜ 5 × 1042 erg s-1 and are marginally inconsistent with a continuing decay of t-5/3, similar to that seen prior to the switch-off. Host photometry enables us to infer a black hole mass of MBH = 3 × 106 M⊙, consistent with the late time X-ray luminosity arising from sub-Eddington accretion onto the black hole in the form of either an unusually optically faint active galactic nucleus or a slowly varying phase of the transient. Optical/IR observations show a clear bump in the light curve at timescales of 30-50 days, with a peak magnitude (corrected for host galaxy extinction) of MR ˜ -22 to -23. The luminosity of the bump is significantly higher than seen in other, non-relativistic TDFs and does not match any re-brightening seen at X-ray or radio wavelengths. Its luminosity, light curve shape, and spectrum are broadly similar to those seen in superluminous supervnovae, although subject to large uncertainties in the correction of the significant host extinction. We discuss these observations in the context of both TDF and massive star origins for Swift J1644+5734 and other candidate relativistic tidal flares.

Condensation on slippery asymmetric bumps

NASA Astrophysics Data System (ADS)

Park, Kyoo-Chul; Kim, Philseok; Grinthal, Alison; He, Neil; Fox, David; Weaver, James C.; Aizenberg, Joanna

2016-03-01

Controlling dropwise condensation is fundamental to water-harvesting systems, desalination, thermal power generation, air conditioning, distillation towers, and numerous other applications. For any of these, it is essential to design surfaces that enable droplets to grow rapidly and to be shed as quickly as possible. However, approaches based on microscale, nanoscale or molecular-scale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach—based on principles derived from Namib desert beetles, cacti, and pitcher plants—that synergistically combines these aspects of condensation and substantially outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle’s bumpy surface geometry in promoting condensation, and using theoretical modelling, we show how to maximize vapour diffusion fluxat the apex of convex millimetric bumps by optimizing the radius of curvature and cross-sectional shape. Integrating this apex geometry with a widening slope, analogous to cactus spines, directly couples facilitated droplet growth with fast directional transport, by creating a free-energy profile that drives the droplet down the slope before its growth rate can decrease. This coupling is further enhanced by a slippery, pitcher-plant-inspired nanocoating that facilitates feedback between coalescence-driven growth and capillary-driven motion on the way down. Bumps that are rationally designed to integrate these mechanisms are able to grow and transport large droplets even against gravity and overcome the effect of an unfavourable temperature gradient. We further observe an unprecedented sixfold-higher exponent of growth rate, faster onset, higher steady-state turnover rate, and a greater volume of water collected compared to other surfaces. We envision that this fundamental understanding and rational design strategy can be applied to a wide range of water-harvesting and phase-change heat-transfer applications.

Accident risk associated with smartphone addiction: A study on university students in Korea.

PubMed

Kim, Hye-Jin; Min, Jin-Young; Kim, Hyun-Jin; Min, Kyoung-Bok

2017-12-01

Background and aims The smartphone is one of the most popular devices, with the average smartphone usage at 162 min/day and the average length of phone usage at 15.79 hr/week. Although significant concerns have been made about the health effects of smartphone addiction, the relationship between smartphone addiction and accidents has rarely been studied. We examined the association between smartphone addiction and accidents among South Korean university students. Methods A total of 608 college students completed an online survey that included their experience of accidents (total number; traffic accidents; falls/slips; bumps/collisions; being trapped in the subway, impalement, cuts, and exit wounds; and burns or electric shocks), their use of smartphone, the type of smartphone content they most frequently used, and other variables of interests. Smartphone addiction was estimated using Smartphone Addiction Proneness Scale, a standardized measure developed by the National Institution in Korea. Results Compared with normal users, participants who were addicted to smartphones were more likely to have experienced any accidents (OR = 1.90, 95% CI: 1.26-2.86), falling from height/slipping (OR = 2.08, 95% CI: 1.10-3.91), and bumps/collisions (OR = 1.83, 95% CI: 1.16-2.87). The proportion of participants who used their smartphones mainly for entertainment was significantly high in both the accident (38.76%) and smartphone addiction (36.40%) groups. Discussion and conclusions We suggest that smartphone addiction was significantly associated with total accident, falling/slipping, and bumps/collisions. This finding highlighted the need for increased awareness of the risk of accidents with smartphone addiction.

Multiwavelength Study of Quiescent States of Mrk 421 with Unprecedented Hard X-Ray Coverage Provided by NuSTAR in 2013

NASA Technical Reports Server (NTRS)

Balokovic, M.; Paneque, D.; Madejski, G.; Chiang, J.; Furniss, A.; Ajello, M.; Alexander, D. M.; Barret, D.; Blandford, R. D.; Boggs, S. E.;

Reliability and Characteristics of Wafer-Level Chip-Scale Packages under Current Stress

NASA Astrophysics Data System (ADS)

Chen, Po-Ying; Kung, Heng-Yu; Lai, Yi-Shao; Hsiung Tsai, Ming; Yeh, Wen-Kuan

2008-02-01

In this work, we present a novel approach and method for elucidating the characteristics of wafer-level chip-scale packages (WLCSPs) for electromigration (EM) tests. The die in WLCSP was directly attached to the substrate via a soldered interconnect. The shrinking of the area of the die that is available for power, and the solder bump also shrinks the volume and increases the density of electrons for interconnect efficiency. The bump current density now approaches to 106 A/cm2, at which point the EM becomes a significant reliability issue. As known, the EM failure depends on numerous factors, including the working temperature and the under bump metallization (UBM) thickness. A new interconnection geometry is adopted extensively with moderate success in overcoming larger mismatches between the displacements of components during current and temperature changes. Both environments and testing parameters for WLCSP are increasingly demanded. Although failure mechanisms are considered to have been eliminated or at least made manageable, new package technologies are again challenging its process, integrity and reliability. WLCSP technology was developed to eliminate the need for encapsulation to ensure compatibility with smart-mount technology (SMT). The package has good handing properties but is now facing serious reliability problems. In this work, we investigated the reliability of a WLCSP subjected to different accelerated current stressing conditions at a fixed ambient temperature of 125 °C. A very strong correlation exists between the mean time to failure (MTTF) of the WLCSP test vehicle and the mean current density that is carried by a solder joint. A series of current densities were applied to the WLCSP architecture; Black's power law was employed in a failure mode simulation. Additionally, scanning electron microscopy (SEM) was adopted to determine the differences existing between high- and low-current-density failure modes.

Extraction optimization and UHPLC method development for determination of the 20-hydroxyecdysone in Sida tuberculata leaves.

PubMed

da Rosa, Hemerson S; Koetz, Mariana; Santos, Marí Castro; Jandrey, Elisa Helena Farias; Folmer, Vanderlei; Henriques, Amélia Teresinha; Mendez, Andreas Sebastian Loureiro

2018-04-01

Sida tuberculata (ST) is a Malvaceae species widely distributed in Southern Brazil. In traditional medicine, ST has been employed as hypoglycemic, hypocholesterolemic, anti-inflammatory and antimicrobial. Additionally, this species is chemically characterized by flavonoids, alkaloids and phytoecdysteroids mainly. The present work aimed to optimize the extractive technique and to validate an UHPLC method for the determination of 20-hydroxyecdsone (20HE) in the ST leaves. Box-Behnken Design (BBD) was used in method optimization. The extractive methods tested were: static and dynamic maceration, ultrasound, ultra-turrax and reflux. In the Box-Behnken three parameters were evaluated in three levels (-1, 0, +1), particle size, time and plant:solvent ratio. In validation method, the parameters of selectivity, specificity, linearity, limits of detection and quantification (LOD, LOQ), precision, accuracy and robustness were evaluated. The results indicate static maceration as better technique to obtain 20HE peak area in ST extract. The optimal extraction from surface response methodology was achieved with the parameters granulometry of 710 nm, 9 days of maceration and plant:solvent ratio 1:54 (w/v). The UHPLC-PDA analytical developed method showed full viability of performance, proving to be selective, linear, precise, accurate and robust for 20HE detection in ST leaves. The average content of 20HE was 0.56% per dry extract. Thus, the optimization of extractive method in ST leaves increased the concentration of 20HE in crude extract, and a reliable method was successfully developed according to validation requirements and in agreement with current legislation. Copyright © 2018 Elsevier Inc. All rights reserved.

Development of an improved sample preparation platform for acidic endogenous hormones in plant tissues using electromembrane extraction.

PubMed

Suh, Joon Hyuk; Han, Sang Beom; Wang, Yu

2018-02-02

Despite their importance in pivotal signaling pathways due to trace quantities and complex matrices, the analysis of plant hormones is a challenge. Here, to improve this issue, we present an electromembrane extraction technology combined with liquid chromatography-tandem mass spectrometry for determination of acidic plant hormones including jasmonic acid, abscisic acid, salicylic acid, benzoic acid, gibberellic acid and gibberellin A 4 in plant tissues. Factors influencing extraction efficiency, such as voltage, extraction time and stirring rate were optimized using a design of experiments. Analytical performance was evaluated in terms of specificity, linearity, limit of quantification, precision, accuracy, recovery and repeatability. The results showed good linearity (r 2  > 0.995), precision and acceptable accuracy. The limit of quantification ranged from 0.1 to 10 ng mL -1 , and the recoveries were 34.6-50.3%. The developed method was applied in citrus leaf samples, showing better clean-up efficiency, as well as higher sensitivity compared to a previous method using liquid-liquid extraction. Organic solvent consumption was minimized during the process, making it an appealing method. More noteworthy, electromembrane extraction has been scarcely applied to plant tissues, and this is the first time that major plant hormones were extracted using this technology, with high sensitivity and selectivity. Taken together, this work gives not only a novel sample preparation platform using an electric field for plant hormones, but also a good example of extracting complex plant tissues in a simple and effective way. Copyright © 2017 Elsevier B.V. All rights reserved.

Method 1664: N-hexane extractable material (hem) and silica gel treated n-hexane extractable material (SGT-HEM) by extraction and gravimetry (oil and grease and total petroleum hydrocarbons), April 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Method 1664 was developed by the United States Environmental Protection Agency Office of Science and Technology to replace previously used gravimetric procedures that employed Freon-113, a Class I CFC, as the extraction solvent for the determination of oil and grease and petroleum hydrocarbons. Method 1664 is a performance-based method applicable to aqueous matrices that requires the use of n-hexane as the extraction solvent and gravimetry as the determinative technique. In addition, QC procedures designed to monitor precision and accuracy have been incorporated into Method 1664.

Automatic exudate detection by fusing multiple active contours and regionwise classification.

PubMed

Harangi, Balazs; Hajdu, Andras

2014-11-01

In this paper, we propose a method for the automatic detection of exudates in digital fundus images. Our approach can be divided into three stages: candidate extraction, precise contour segmentation and the labeling of candidates as true or false exudates. For candidate detection, we borrow a grayscale morphology-based method to identify possible regions containing these bright lesions. Then, to extract the precise boundary of the candidates, we introduce a complex active contour-based method. Namely, to increase the accuracy of segmentation, we extract additional possible contours by taking advantage of the diverse behavior of different pre-processing methods. After selecting an appropriate combination of the extracted contours, a region-wise classifier is applied to remove the false exudate candidates. For this task, we consider several region-based features, and extract an appropriate feature subset to train a Naïve-Bayes classifier optimized further by an adaptive boosting technique. Regarding experimental studies, the method was tested on publicly available databases both to measure the accuracy of the segmentation of exudate regions and to recognize their presence at image-level. In a proper quantitative evaluation on publicly available datasets the proposed approach outperformed several state-of-the-art exudate detector algorithms. Copyright © 2014 Elsevier Ltd. All rights reserved.

Rapid determination of alkaloids in Macleaya cordata using ionic liquid extraction followed by multiple reaction monitoring UPLC-MS/MS analysis.

PubMed

Li, Linqiu; Huang, Mingyuan; Shao, Junli; Lin, Bokun; Shen, Qing

2017-02-20

The ultrasonic-assisted extraction (UAE) and ionic liquid based dispersive liquid-liquid microextraction (IL-DLLME) have been successfully applied in extracting of six alkaloids from M. cordata. 1-hexyl-3-methylimidazolium tetrafluoroborate ([C 6 MIM][BF 4 ]) aqueous solution was used as extraction solvent. The target analytes in raw material were deposited into a single drop of 1-hexyl-3-methylimidazolium hexafluorophosphate ([C 6 MIM][PF 6 ]), which was in situ formed by mixing [C 6 MIM][BF 4 ] and potassium hexafluorophosphate ([K][PF 6 ]. Afterwards, the extract was analyzed by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) in multiple-reaction monitoring (MRM) mode. The proposed method was fully validated in terms of linearity (0.9983-0.9992), LOD (0.080ngmL -1 ), LOQ (0.25ngmL -1 ), intra-day precision (<5.46%), inter-day precision (<6.36%), and recovery (86.42-112.48%). The results indicate that the approach of combining IL-DLLME with UPLC-MS/MS is powerful and practical for analyzing alkaloids in M. cordata., and it also has great potential for comprehensive quality control of other herbal medicines. Copyright © 2016 Elsevier B.V. All rights reserved.

Quantitative determination of methamphetamine in oral fluid by liquid-liquid extraction and gas chromatography/mass spectrometry.

PubMed

Bahmanabadi, L; Akhgari, M; Jokar, F; Sadeghi, H B

2017-02-01

Methamphetamine abuse is one of the most medical and social problems many countries face. In spite of the ban on the use of methamphetamine, it is widely available in Iran's drug black market. There are many analytical methods for the detection of methamphetamine in biological specimen. Oral fluid has become a popular specimen to test for the presence of methamphetamine. The purpose of the present study was to develop a method for the extraction and detection of methamphetamine in oral fluid samples using liquid-liquid extraction (LLE) and gas chromatography/mass spectrometry (GC/MS) methods. An analytical study was designed in that blank and 50 authentic oral fluid samples were collected to be first extracted by LLE and subsequently analysed by GC/MS. The method was fully validated and showed an excellent intra- and inter-assay precision (reflex sympathetic dystrophy ˂ 10%) for external quality control samples. Recovery with LLE methods was 96%. Limit of detection and limit of quantitation were 5 and 15 ng/mL, respectively. The method showed high selectivity, no additional peak due to interfering substances in samples was observed. The introduced method was sensitive, accurate and precise enough for the extraction of methamphetamine from oral fluid samples in forensic toxicology laboratories.

[Medical imaging in tumor precision medicine: opportunities and challenges].

PubMed

Xu, Jingjing; Tan, Yanbin; Zhang, Minming

2017-05-25

Tumor precision medicine is an emerging approach for tumor diagnosis, treatment and prevention, which takes account of individual variability of environment, lifestyle and genetic information. Tumor precision medicine is built up on the medical imaging innovations developed during the past decades, including the new hardware, new imaging agents, standardized protocols, image analysis and multimodal imaging fusion technology. Also the development of automated and reproducible analysis algorithm has extracted large amount of information from image-based features. With the continuous development and mining of tumor clinical and imaging databases, the radiogenomics, radiomics and artificial intelligence have been flourishing. Therefore, these new technological advances bring new opportunities and challenges to the application of imaging in tumor precision medicine.

Precision measurements of linear scattering density using muon tomography

NASA Astrophysics Data System (ADS)

Åström, E.; Bonomi, G.; Calliari, I.; Calvini, P.; Checchia, P.; Donzella, A.; Faraci, E.; Forsberg, F.; Gonella, F.; Hu, X.; Klinger, J.; Sundqvist Ökvist, L.; Pagano, D.; Rigoni, A.; Ramous, E.; Urbani, M.; Vanini, S.; Zenoni, A.; Zumerle, G.

2016-07-01

We demonstrate that muon tomography can be used to precisely measure the properties of various materials. The materials which have been considered have been extracted from an experimental blast furnace, including carbon (coke) and iron oxides, for which measurements of the linear scattering density relative to the mass density have been performed with an absolute precision of 10%. We report the procedures that are used in order to obtain such precision, and a discussion is presented to address the expected performance of the technique when applied to heavier materials. The results we obtain do not depend on the specific type of material considered and therefore they can be extended to any application.

Improvement of the lipophilic-oxygen radical absorbance capacity (L-ORAC) method and single-laboratory validation.

PubMed

Watanabe, Jun; Oki, Tomoyuki; Takebayashi, Jun; Yamasaki, Koji; Takano-Ishikawa, Yuko; Hino, Akihiro; Yasui, Akemi

2013-01-01

We improved the procedure for lipophilic-oxygen radical absorbance capacity (L-ORAC) measurement for better repeatability and intermediate precision. A sealing film was placed on the assay plate, and glass vials and microdispensers equipped with glass capillaries were used. The antioxidant capacities of food extracts can be evaluated by this method with nearly the same precision as antioxidant solutions.

Large-scale extraction of accurate drug-disease treatment pairs from biomedical literature for drug repurposing

PubMed Central

2013-01-01

Background A large-scale, highly accurate, machine-understandable drug-disease treatment relationship knowledge base is important for computational approaches to drug repurposing. The large body of published biomedical research articles and clinical case reports available on MEDLINE is a rich source of FDA-approved drug-disease indication as well as drug-repurposing knowledge that is crucial for applying FDA-approved drugs for new diseases. However, much of this information is buried in free text and not captured in any existing databases. The goal of this study is to extract a large number of accurate drug-disease treatment pairs from published literature. Results In this study, we developed a simple but highly accurate pattern-learning approach to extract treatment-specific drug-disease pairs from 20 million biomedical abstracts available on MEDLINE. We extracted a total of 34,305 unique drug-disease treatment pairs, the majority of which are not included in existing structured databases. Our algorithm achieved a precision of 0.904 and a recall of 0.131 in extracting all pairs, and a precision of 0.904 and a recall of 0.842 in extracting frequent pairs. In addition, we have shown that the extracted pairs strongly correlate with both drug target genes and therapeutic classes, therefore may have high potential in drug discovery. Conclusions We demonstrated that our simple pattern-learning relationship extraction algorithm is able to accurately extract many drug-disease pairs from the free text of biomedical literature that are not captured in structured databases. The large-scale, accurate, machine-understandable drug-disease treatment knowledge base that is resultant of our study, in combination with pairs from structured databases, will have high potential in computational drug repurposing tasks. PMID:23742147

Combining automatic table classification and relationship extraction in extracting anticancer drug-side effect pairs from full-text articles.

PubMed

Xu, Rong; Wang, QuanQiu

2015-02-01

Anticancer drug-associated side effect knowledge often exists in multiple heterogeneous and complementary data sources. A comprehensive anticancer drug-side effect (drug-SE) relationship knowledge base is important for computation-based drug target discovery, drug toxicity predication and drug repositioning. In this study, we present a two-step approach by combining table classification and relationship extraction to extract drug-SE pairs from a large number of high-profile oncological full-text articles. The data consists of 31,255 tables downloaded from the Journal of Oncology (JCO). We first trained a statistical classifier to classify tables into SE-related and -unrelated categories. We then extracted drug-SE pairs from SE-related tables. We compared drug side effect knowledge extracted from JCO tables to that derived from FDA drug labels. Finally, we systematically analyzed relationships between anti-cancer drug-associated side effects and drug-associated gene targets, metabolism genes, and disease indications. The statistical table classifier is effective in classifying tables into SE-related and -unrelated (precision: 0.711; recall: 0.941; F1: 0.810). We extracted a total of 26,918 drug-SE pairs from SE-related tables with a precision of 0.605, a recall of 0.460, and a F1 of 0.520. Drug-SE pairs extracted from JCO tables is largely complementary to those derived from FDA drug labels; as many as 84.7% of the pairs extracted from JCO tables have not been included a side effect database constructed from FDA drug labels. Side effects associated with anticancer drugs positively correlate with drug target genes, drug metabolism genes, and disease indications. Copyright © 2014 Elsevier Inc. All rights reserved.

Characterization of modified allergen extracts by in vitro beta-hexosaminidase release from rat basophils.

PubMed

Gehlhar, Kirsten; Peters, Marcus; Brockmann, Kirsten; van Schijndel, Hans; Bufe, Albrecht

2005-04-01

To date, there is no well-established test available that can be used to measure functional properties of modified allergens (allergoids). Due to the cross-linking process, the IgE-binding capacity of the allergens, normally necessary for their characterization, is lost. The aim of this study was to test whether the rat basophilic leukaemia (RBL) cell assay (beta-hexosaminidase release by rat basophils upon allergen stimulation) can be adopted to characterize allergoids and to evaluate the assay for testing allergoids and native allergens as well. Mice were immunized with native and modified Phleumpratense extracts in the presence of alum. Their sera were used to sensitize RBL-2H3 cells and measure basophil stimulation induced by different allergen extracts in the presence or absence of various additives. Sera containing specific IgE against both extract formulations were obtained. Native as well as modified extracts induced dose-dependent beta-hexosaminidase release from RBL cells. Both extracts were used to evaluate the characteristics of the assay, which showed high precision. Storage conditions were chosen to enhance extract degradation, which could be read directly from the altered stimulatory capacity of the extracts. Additives turned out to have diverse effects on the assay, whereas phenol had no measurable effect, alum had an inhibitory effect and glycerol elevated basophil activation. For the first time, a reliable, precise in vitro assay is available that is able to directly measure the properties of modified allergen extracts after their production process. The test is well evaluated and its advantages and limitations are discussed in this report. Copyright (c) 2005 S. Karger AG, Basel

Capabilities and limitations of dispersive liquid-liquid microextraction with solidification of floating organic drop for the extraction of organic pollutants from water samples.

PubMed

Vera-Avila, Luz E; Rojo-Portillo, Tania; Covarrubias-Herrera, Rosario; Peña-Alvarez, Araceli

2013-12-17

Dispersive liquid-liquid microextraction with solidification of floating organic drop (DLLME-SFO) is one of the most interesting sample preparation techniques developed in recent years. Although several applications have been reported, the potentiality and limitations of this simple and rapid extraction technique have not been made sufficiently explicit. In this work, the extraction efficiency of DLLME-SFO for pollutants from different chemical families was determined. Studied compounds include: 10 polycyclic aromatic hydrocarbons, 5 pesticides (chlorophenoxy herbicides and DDT), 8 phenols and 6 sulfonamides, thus, covering a large range of polarity and hydrophobicity (LogKow 0-7, overall). After optimization of extraction conditions using 1-dodecanol as extractant, the procedure was applied for extraction of each family from 10-mL spiked water samples, only adjusting sample pH as required. Absolute recoveries for pollutants with LogKow 3-7 were >70% and recovery values within this group (18 compounds) were independent of structure or hydrophobicity; the precision of recovery was very acceptable (RSD<12%) and linear behavior was observed in the studied concentration range (r(2)>0.995). Extraction recoveries for pollutants with LogKow 1.46-2.8 were in the range 13-62%, directly depending on individual LogKow values; however, good linearity (r(2)>0.993) and precision (RSD<6.5%) were also demonstrated for these polar solutes, despite recovery level. DLLME-SFO with 1-dodecanol completely failed for extraction of compounds with LogKow≤1 (sulfa drugs), other more polar extraction solvents (ionic liquids) should be explored for highly hydrophilic pollutants. Copyright © 2013 Elsevier B.V. All rights reserved.

Precise determination of the deuteron spin structure at low to moderate Q2 with CLAS and extraction of the neutron contribution

NASA Astrophysics Data System (ADS)

Guler, N.; Fersch, R. G.; Kuhn, S. E.; Bosted, P.; Griffioen, K. A.; Keith, C.; Minehart, R.; Prok, Y.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Crabb, D.; Crede, V.; D'Angelo, A.; Dashyan, N.; Deur, A.; Djalali, C.; Dodge, G. E.; Dupre, R.; Alaoui, A. El; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Garillon, B.; Garçon, M.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hughes, S. M.; Hyde, C. E.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Livingston, K.; Lu, H. Y.; Mayer, M.; MacGregor, I. J. D.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Movsisyan, A.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Simonyan, A.; Skorodumina, Iu.; Sokhan, D.; Sparveris, N.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Voutier, E.; Walford, N. K.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

2015-11-01

We present the final results for the deuteron spin structure functions obtained from the full data set collected in 2000-2001 with Jefferson Lab's continuous electron beam accelerator facility (CEBAF) using the CEBAF large acceptance spectrometer (CLAS). Polarized electrons with energies of 1.6, 2.5, 4.2, and 5.8 GeV were scattered from deuteron (15ND3 ) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double-spin asymmetry, the virtual photon absorption asymmetry A1d and the polarized structure function g1d were extracted over a wide kinematic range (0.05 GeV2

Authentication of Piper betle L. folium and quantification of their antifungal-activity.

PubMed

Wirasuta, I Made Agus Gelgel; Srinadi, I Gusti Ayu Made; Dwidasmara, Ida Bagus Gede; Ardiyanti, Ni Luh Putu Putri; Trisnadewi, I Gusti Ayu Arya; Paramita, Ni Luh Putu Vidya

2017-07-01

The TLC profiles of intra- and inter-day precision for Piper betle L . (PBL) folium methanol extract was studied for their peak marker recognition and identification. The Numerical chromatographic parameters (NCPs) of the peak markers, the hierarchical clustering analysis (HCA) and the principal component analysis (PCA) were applied to authenticate the PBL. folium extract from other Piper species folium extract and to ensure the antifungal activity quality of the PBL essential oil. The spotted extract was developed with the mobile phase of toluene: ethyl acetate; 93:7, (v/v). The eluted plate was viewed with the TLC-Visualizer, scanned under absorption and fluorescent mode detection, and on each sample the in-situ UV spectra were recorded between 190 to 400 nm. The NCPs profiles of intra- and inter-day precision results offered multi-dimensional chromatogram fingerprints for better marker peak pattern recognition and identification. Using the r -value fingerprints data series generated with this method allowed more precise discrimination the PBL. from other Piper species compared to the marker peak area fingerprint method. The cosine pair comparison was a simple method for authentication of two different fingerprints. The ward linkage clustering and the pair cross-correlation comparison were better chemometric methods to determine the consistency peak area ratio between fingerprints. The first component PCA-loading values of peak marker area fingerprints were correlated linearly to both the bio-marker concentration as well as the antifungal activity. This relationship could be used to control the quality and pharmacological potency. This simple method was developed for the authentication and quantification of herbal medicine.

Precise determination of the deuteron spin structure at low to moderate Q 2 with CLAS and extraction of the neutron contribution

DOE PAGES

Guler, N.; Fersch, R. G.; Kuhn, S. E.; ...

2015-11-02

In this study, we present the final results for the deuteron spin structure functions obtained from the full data set collected with Jefferson Lab's CLAS in 2000-2001. Polarized electrons with energies of 1.6, 2.5, 4.2 and 5.8 GeV were scattered from deuteron ( 15ND 3) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double spin asymmetry, the virtual photon absorption asymmetry A d 1 and the polarized structure function g d 1 were extracted over a wide kinematic range (0.05 GeV2 < Q2 < 5 GeV2 and 0.9 GeV < W < 3 GeV).more » We use an unfolding procedure and a parametrization of the corresponding proton results to extract from these data the polarized structure functions A n 1 and g 1 n of the (bound) neutron, which are so far unknown in the resonance region, W < 2 GeV. We compare our final results, including several moments of the deuteron and neutron spin structure functions, with various theoretical models and expectations as well as parametrizations of the world data. The unprecedented precision and dense kinematic coverage of these data can aid in future extractions of polarized parton distributions, tests of perturbative QCD predictions for the quark polarization at large x, a better understanding of quark-hadron duality, and more precise values for higher-twist matrix elements in the framework of the Operator Product Expansion.« less

Using Natural Language Processing to Extract Abnormal Results From Cancer Screening Reports.

PubMed

Moore, Carlton R; Farrag, Ashraf; Ashkin, Evan

2017-09-01

Numerous studies show that follow-up of abnormal cancer screening results, such as mammography and Papanicolaou (Pap) smears, is frequently not performed in a timely manner. A contributing factor is that abnormal results may go unrecognized because they are buried in free-text documents in electronic medical records (EMRs), and, as a result, patients are lost to follow-up. By identifying abnormal results from free-text reports in EMRs and generating alerts to clinicians, natural language processing (NLP) technology has the potential for improving patient care. The goal of the current study was to evaluate the performance of NLP software for extracting abnormal results from free-text mammography and Pap smear reports stored in an EMR. A sample of 421 and 500 free-text mammography and Pap reports, respectively, were manually reviewed by a physician, and the results were categorized for each report. We tested the performance of NLP to extract results from the reports. The 2 assessments (criterion standard versus NLP) were compared to determine the precision, recall, and accuracy of NLP. When NLP was compared with manual review for mammography reports, the results were as follows: precision, 98% (96%-99%); recall, 100% (98%-100%); and accuracy, 98% (96%-99%). For Pap smear reports, the precision, recall, and accuracy of NLP were all 100%. Our study developed NLP models that accurately extract abnormal results from mammography and Pap smear reports. Plans include using NLP technology to generate real-time alerts and reminders for providers to facilitate timely follow-up of abnormal results.

Mummies, Vampires and Things That Go Bump in the Night.

ERIC Educational Resources Information Center

McCormack, Bunnie

1994-01-01

Describes two interdisciplinary programs developed for middle school students that focus on mummies and vampires and include social studies, art, language arts, creative dramatics, and media production skills. Content, multimedia, new and interesting information, and student participation are emphasized. (11 references) (LRW)

Revised Reynolds Stress and Triple Product Models

NASA Technical Reports Server (NTRS)

Olsen, Michael E.; Lillard, Randolph P.

2017-01-01

Revised versions of Lag methodology Reynolds-stress and triple product models are applied to accepted test cases to assess the improvement, or lack thereof, in the prediction capability of the models. The Bachalo-Johnson bump flow is shown as an example for this abstract submission.

Identification and evaluation of pavement-bridge interface ride quality improvement and corrective strategies : executive summary report.

DOT National Transportation Integrated Search

2011-01-01

Bridge owners have long recognized that the approach pavement at bridges is prone to exhibiting both : settlement and cracking, which manifest as the bump at the end of the bridge. This deterioration : requires considerable on-going maintenance...

Field demonstration of new bridge approach slab designs and performance : [tech summary].

DOT National Transportation Integrated Search

2014-06-01

The Louisiana Department of Transportation and Development (DOTD) has launched a major e ort to solve : the bridge bump problem by changing the design of approach slabs where di erential settlement is expected. : The objective is to nd a fe...

Geopolitical and strategic aspects of present and future use of nuclear energy

NASA Astrophysics Data System (ADS)

Blix, Hans

2012-06-01

Nuclear power is at a bump in the road - not at the end of the road. We must promote further safe development. Nuclear weapons are obsolescent. The Cold War is over and further détente will lead to disarmament.

Characterization of low temperature Cu/In bonding for fine-pitch interconnects in three-dimensional integration

NASA Astrophysics Data System (ADS)

Panchenko, Iuliana; Bickel, Steffen; Meyer, Jörg; Mueller, Maik; Wolf, Jürgen M.

2018-02-01

This study presents the results for Cu/In bonding based on the solid-liquid interdiffusion (SLID) principle for fine-pitch interconnects in three-dimensional integration. The microbumps were fabricated on Si wafers (55 µm pitch, 25 µm top bump diameter, 35 µm bottom bump diameter). In was electroplated directly on Cu only on the top die microbumps. Two different In thicknesses were manufactured (3 and 5 µm). The interconnects were successfully fabricated at a bonding temperature of 170 °C. High temperature storage was carried out at 150 and 200 °C for different times between 2 and 72 h directly after the interconnect formation in order to investigate the temperature stability. The microstructure was analyzed by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The intermetallic compound (IMC) found in the microbumps after electroplating was CuIn2. The intermetallic interlayer consists of Cu11In9 and a thin layer of Cu2In after bonding and isothermal storage.

Bump hunting in LHC t t ¯ events

NASA Astrophysics Data System (ADS)

Czakon, Michal; Heymes, David; Mitov, Alexander

2016-12-01

We demonstrate that a purposefully normalized next-to-next-to-leading-order mt t ¯ differential spectrum can have very small theoretical uncertainty and, in particular, a small sensitivity to the top quark mass. Such an observable can thus be a very effective bump-hunting tool for resonances decaying to t t ¯ events during LHC run II and beyond. To illustrate how the approach works, we concentrate on one specific example of current interest, namely, the possible 750 GeV digamma excess resonance Φ . Considering only theoretical uncertainties, we demonstrate that it is possible to distinguish p p →Φ →t t ¯ signals studied in the recent literature [Hespel, Maltoni, and Vryonidou, J. High Energy Phys. 10 (2016) 016, 10.1007/JHEP10(2016)016] from the pure Standard Model background with very high significance. Alternatively, in the case of nonobservation, a strong upper limit on the decay rate Φ →t t ¯ can be placed.

PROBING THE ROLE OF CARBON IN ULTRAVIOLET EXTINCTION ALONG GALACTIC SIGHT LINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parvathi, V. S.; Babu, B. R. S.; Sofia, U. J.

2012-11-20

We report previously undetermined interstellar gas and dust-phase carbon abundances along 15 Galactic sight lines based on archival data of the strong 1334.5323 A transition observed with the Space Telescope Imaging Spectrograph. These are combined with previously reported carbon measurements along six sight lines to produce a complete sample of interstellar C II measurements determined with the 1334 A transition. Our data set includes a variety of Galactic disk environments characterized by different extinctions and samples paths ranging over three orders of magnitude in average density of hydrogen ((n(H))). Our data support the idea that dust, specifically carbon-based grains, aremore » processed in the neutral interstellar medium. We, however, do not find that the abundance of carbon in dust or the grain-size distribution is related to the strength of the 2175 A bump. This is surprising, given that many current models have polycyclic aromatic hydrocarbons as the bump-producing dust.« less

Optimization of the multi-turn injection efficiency for a medical synchrotron

NASA Astrophysics Data System (ADS)

Kim, J.; Yoon, M.; Yim, H.

2016-09-01

We present a method for optimizing the multi-turn injection efficiency for a medical synchrotron. We show that for a given injection energy, the injection efficiency can be greatly enhanced by choosing transverse tunes appropriately and by optimizing the injection bump and the number of turns required for beam injection. We verify our study by applying the method to the Korea Heavy Ion Medical Accelerator (KHIMA) synchrotron which is currently being built at the campus of Dongnam Institute of Radiological and Medical Sciences (DIRAMS) in Busan, Korea. First the frequency map analysis was performed with the help of the ELEGANT and the ACCSIM codes. The tunes that yielded good injection efficiency were then selected. With these tunes, the injection bump and the number of turns required for injection were then optimized by tracking a number of particles for up to one thousand turns after injection, beyond which no further beam loss occurred. Results for the optimization of the injection efficiency for proton ions are presented.

Reconciling Models of Luminous Blazars with Magnetic Fluxes Determined by Radio Core-shift Measurements

NASA Astrophysics Data System (ADS)

Nalewajko, Krzysztof; Sikora, Marek; Begelman, Mitchell C.

2014-11-01

Estimates of magnetic field strength in relativistic jets of active galactic nuclei, obtained by measuring the frequency-dependent radio core location, imply that the total magnetic fluxes in those jets are consistent with the predictions of the magnetically arrested disk (MAD) scenario of jet formation. On the other hand, the magnetic field strength determines the luminosity of the synchrotron radiation, which forms the low-energy bump of the observed blazar spectral energy distribution (SED). The SEDs of the most powerful blazars are strongly dominated by the high-energy bump, which is most likely due to the external radiation Compton mechanism. This high Compton dominance may be difficult to reconcile with the MAD scenario, unless (1) the geometry of external radiation sources (broad-line region, hot-dust torus) is quasi-spherical rather than flat, or (2) most gamma-ray radiation is produced in jet regions of low magnetization, e.g., in magnetic reconnection layers or in fast jet spines.

Geodesic acoustic mode driven by energetic particles with bump-on-tail distribution

NASA Astrophysics Data System (ADS)

Ren, Haijun; Wang, Hao

2018-04-01

Energetic-particle-driven geodesic acoustic mode (EGAM) is analytically investigated by adopting the bump-on-tail distribution for energetic particles (EPs), which is created by the fact that the charge exchange time (τcx ) is sufficiently shorter than the slowing down time (τsl ). The dispersion relation is derived in the use of gyro-kinetic equations. Due to the finite ratio of the critical energy and the initial energy of EPs, defined as τc , the dispersion relation is numerically evaluated and the effect of finite τc is examined. Following relative simulation and experimental work, we specifically considered two cases: τsl/τcx = 3.4 and τsl/τcx = 20.4 . The pitch angle is shown to significantly enhance the growth rate and meanwhile, the real frequency is dramatically decreased with increasing pitch angle. The excitation of high-frequency EGAM is found, and this is consistent with both the experiment and the simulation. The number density effect of energetic particles, represented by \

Investigation of stickiness influence in the anomalous transport and diffusion for a non-dissipative Fermi-Ulam model

NASA Astrophysics Data System (ADS)

Livorati, André L. P.; Palmero, Matheus S.; Díaz-I, Gabriel; Dettmann, Carl P.; Caldas, Iberê L.; Leonel, Edson D.

2018-02-01

We study the dynamics of an ensemble of non interacting particles constrained by two infinitely heavy walls, where one of them is moving periodically in time, while the other is fixed. The system presents mixed dynamics, where the accessible region for the particle to diffuse chaotically is bordered by an invariant spanning curve. Statistical analysis for the root mean square velocity, considering high and low velocity ensembles, leads the dynamics to the same steady state plateau for long times. A transport investigation of the dynamics via escape basins reveals that depending of the initial velocity ensemble, the decay rates of the survival probability present different shapes and bumps, in a mix of exponential, power law and stretched exponential decays. After an analysis of step-size averages, we found that the stable manifolds play the role of a preferential path for faster escape, being responsible for the bumps and different shapes of the survival probability.

RECONCILING MODELS OF LUMINOUS BLAZARS WITH MAGNETIC FLUXES DETERMINED BY RADIO CORE-SHIFT MEASUREMENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nalewajko, Krzysztof; Begelman, Mitchell C.; Sikora, Marek, E-mail: knalew@stanford.edu

2014-11-20

Estimates of magnetic field strength in relativistic jets of active galactic nuclei, obtained by measuring the frequency-dependent radio core location, imply that the total magnetic fluxes in those jets are consistent with the predictions of the magnetically arrested disk (MAD) scenario of jet formation. On the other hand, the magnetic field strength determines the luminosity of the synchrotron radiation, which forms the low-energy bump of the observed blazar spectral energy distribution (SED). The SEDs of the most powerful blazars are strongly dominated by the high-energy bump, which is most likely due to the external radiation Compton mechanism. This high Comptonmore » dominance may be difficult to reconcile with the MAD scenario, unless (1) the geometry of external radiation sources (broad-line region, hot-dust torus) is quasi-spherical rather than flat, or (2) most gamma-ray radiation is produced in jet regions of low magnetization, e.g., in magnetic reconnection layers or in fast jet spines.« less

A possible macronova in the late afterglow of the long-short burst GRB 060614.

PubMed

Yang, Bin; Jin, Zhi-Ping; Li, Xiang; Covino, Stefano; Zheng, Xian-Zhong; Hotokezaka, Kenta; Fan, Yi-Zhong; Piran, Tsvi; Wei, Da-Ming

2015-06-11

Long-duration (>2 s) γ-ray bursts that are believed to originate from the death of massive stars are expected to be accompanied by supernovae. GRB 060614, that lasted 102 s, lacks a supernova-like emission down to very stringent limits and its physical origin is still debated. Here we report the discovery of near-infrared bump that is significantly above the regular decaying afterglow. This red bump is inconsistent with even the weakest known supernova. However, it can arise from a Li-Paczyński macronova--the radioactive decay of debris following a compact binary merger. If this interpretation is correct, GRB 060614 arose from a compact binary merger rather than from the death of a massive star and it was a site of a significant production of heavy r-process elements. The significant ejected mass favours a black hole-neutron star merger but a double neutron star merger cannot be ruled out.

Integrating Multiple On-line Knowledge Bases for Disease-Lab Test Relation Extraction.

PubMed

Zhang, Yaoyun; Soysal, Ergin; Moon, Sungrim; Wang, Jingqi; Tao, Cui; Xu, Hua

2015-01-01

A computable knowledge base containing relations between diseases and lab tests would be a great resource for many biomedical informatics applications. This paper describes our initial step towards establishing a comprehensive knowledge base of disease and lab tests relations utilizing three public on-line resources. LabTestsOnline, MedlinePlus and Wikipedia are integrated to create a freely available, computable disease-lab test knowledgebase. Disease and lab test concepts are identified using MetaMap and relations between diseases and lab tests are determined based on source-specific rules. Experimental results demonstrate a high precision for relation extraction, with Wikipedia achieving the highest precision of 87%. Combining the three sources reached a recall of 51.40%, when compared with a subset of disease-lab test relations extracted from a reference book. Moreover, we found additional disease-lab test relations from on-line resources, indicating they are complementary to existing reference books for building a comprehensive disease and lab test relation knowledge base.

Autonomous celestial navigation based on Earth ultraviolet radiance and fast gradient statistic feature extraction

NASA Astrophysics Data System (ADS)

Lu, Shan; Zhang, Hanmo

2016-01-01

To meet the requirement of autonomous orbit determination, this paper proposes a fast curve fitting method based on earth ultraviolet features to obtain accurate earth vector direction, in order to achieve the high precision autonomous navigation. Firstly, combining the stable characters of earth ultraviolet radiance and the use of transmission model software of atmospheric radiation, the paper simulates earth ultraviolet radiation model on different time and chooses the proper observation band. Then the fast improved edge extracting method combined Sobel operator and local binary pattern (LBP) is utilized, which can both eliminate noises efficiently and extract earth ultraviolet limb features accurately. And earth's centroid locations on simulated images are estimated via the least square fitting method using part of the limb edges. Taken advantage of the estimated earth vector direction and earth distance, Extended Kalman Filter (EKF) is applied to realize the autonomous navigation finally. Experiment results indicate the proposed method can achieve a sub-pixel earth centroid location estimation and extremely enhance autonomous celestial navigation precision.

Precise on-machine extraction of the surface normal vector using an eddy current sensor array

NASA Astrophysics Data System (ADS)

Wang, Yongqing; Lian, Meng; Liu, Haibo; Ying, Yangwei; Sheng, Xianjun

2016-11-01

To satisfy the requirements of on-machine measurement of the surface normal during complex surface manufacturing, a highly robust normal vector extraction method using an Eddy current (EC) displacement sensor array is developed, the output of which is almost unaffected by surface brightness, machining coolant and environmental noise. A precise normal vector extraction model based on a triangular-distributed EC sensor array is first established. Calibration of the effects of object surface inclination and coupling interference on measurement results, and the relative position of EC sensors, is involved. A novel apparatus employing three EC sensors and a force transducer was designed, which can be easily integrated into the computer numerical control (CNC) machine tool spindle and/or robot terminal execution. Finally, to test the validity and practicability of the proposed method, typical experiments were conducted with specified testing pieces using the developed approach and system, such as an inclined plane and cylindrical and spherical surfaces.

Development of a screening method for the determination of forty-nine priority pollutants in soil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kiang, P.H.T.

1985-01-01

An extraction procedure followed by capillary GC-MS analysis was used to determine soil pollutants. Dual pH solutions with methylene chloride were used as extraction solvent system. Both base/neutral and acidic fractions were analyzed on the same fused silica 30 meter SPB-1 (SE-30) column. A GC-FID with a 60 meter wide-bore SPB-1 glass capillary column was used for quantitative analysis due to its larger sample capacity and higher sensitivity. The precision and accuracy for 5.1 ppm (51 ..mu..g/10 g) concentration in zero soil was less than 25% RSD. A headspace technique was also developed for the determination of volatile compounds. Themore » same instrumental conditions and columns were used as in the extraction procedure. The precision and accuracy for 3 grams soil sample spiked with 5.1 ppm (52 ..mu..g/10 mL) pollutant mixture in a 20 mL vial was less than 3% RSD.« less

Determination of rifampicin in human plasma by high-performance liquid chromatography coupled with ultraviolet detection after automatized solid-liquid extraction.

PubMed

Louveau, B; Fernandez, C; Zahr, N; Sauvageon-Martre, H; Maslanka, P; Faure, P; Mourah, S; Goldwirt, L

2016-12-01

A precise and accurate high-performance liquid chromatography (HPLC) quantification method of rifampicin in human plasma was developed and validated using ultraviolet detection after an automatized solid-phase extraction. The method was validated with respect to selectivity, extraction recovery, linearity, intra- and inter-day precision, accuracy, lower limit of quantification and stability. Chromatographic separation was performed on a Chromolith RP 8 column using a mixture of 0.05 m acetate buffer pH 5.7-acetonitrile (35:65, v/v) as mobile phase. The compounds were detected at a wavelength of 335 nm with a lower limit of quantification of 0.05 mg/L in human plasma. Retention times for rifampicin and 6,7-dimethyl-2,3-di(2-pyridyl) quinoxaline used as internal standard were respectively 3.77 and 4.81 min. This robust and exact method was successfully applied in routine for therapeutic drug monitoring in patients treated with rifampicin. Copyright © 2016 John Wiley & Sons, Ltd.

Validation of quantitative method for azoxystrobin residues in green beans and peas.

PubMed

Abdelraheem, Ehab M H; Hassan, Sayed M; Arief, Mohamed M H; Mohammad, Somaia G

2015-09-01

This study presents a method validation for extraction and quantitative analysis of azoxystrobin residues in green beans and peas using HPLC-UV and the results confirmed by GC-MS. The employed method involved initial extraction with acetonitrile after the addition of salts (magnesium sulfate and sodium chloride), followed by a cleanup step by activated neutral carbon. Validation parameters; linearity, matrix effect, LOQ, specificity, trueness and repeatability precision were attained. The spiking levels for the trueness and the precision experiments were (0.1, 0.5, 3 mg/kg). For HPLC-UV analysis, mean recoveries ranged between 83.69% to 91.58% and 81.99% to 107.85% for green beans and peas, respectively. For GC-MS analysis, mean recoveries ranged from 76.29% to 94.56% and 80.77% to 100.91% for green beans and peas, respectively. According to these results, the method has been proven to be efficient for extraction and determination of azoxystrobin residues in green beans and peas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Last Glacial Maximum Salinity Reconstruction

NASA Astrophysics Data System (ADS)

Homola, K.; Spivack, A. J.

2016-12-01

It has been previously demonstrated that salinity can be reconstructed from sediment porewater. The goal of our study is to reconstruct high precision salinity during the Last Glacial Maximum (LGM). Salinity is usually determined at high precision via conductivity, which requires a larger volume of water than can be extracted from a sediment core, or via chloride titration, which yields lower than ideal precision. It has been demonstrated for water column samples that high precision density measurements can be used to determine salinity at the precision of a conductivity measurement using the equation of state of seawater. However, water column seawater has a relatively constant composition, in contrast to porewater, where variations from standard seawater composition occur. These deviations, which affect the equation of state, must be corrected for through precise measurements of each ion's concentration and knowledge of apparent partial molar density in seawater. We have developed a density-based method for determining porewater salinity that requires only 5 mL of sample, achieving density precisions of 10-6 g/mL. We have applied this method to porewater samples extracted from long cores collected along a N-S transect across the western North Atlantic (R/V Knorr cruise KN223). Density was determined to a precision of 2.3x10-6 g/mL, which translates to salinity uncertainty of 0.002 gms/kg if the effect of differences in composition is well constrained. Concentrations of anions (Cl-, and SO4-2) and cations (Na+, Mg+, Ca+2, and K+) were measured. To correct salinities at the precision required to unravel LGM Meridional Overturning Circulation, our ion precisions must be better than 0.1% for SO4-/Cl- and Mg+/Na+, and 0.4% for Ca+/Na+, and K+/Na+. Alkalinity, pH and Dissolved Inorganic Carbon of the porewater were determined to precisions better than 4% when ratioed to Cl-, and used to calculate HCO3-, and CO3-2. Apparent partial molar densities in seawater were determined experimentally. We compare the high precision salinity profiles determined using our new method to profiles determined from the traditional chloride titrations of parallel samples. Our technique provides a more accurate reconstruction of past salinity, informing questions of water mass composition and distribution during the LGM.

METHOD 544. DETERMINATION OF MICROCYSTINS AND NODULARIN IN DRINKING WATER BY SOLID PHASE EXTRACTION AND LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY (LC/MS/MS)

EPA Science Inventory

Method 544 is an accurate and precise analytical method to determine six microcystins (including MC-LR) and nodularin in drinking water using solid phase extraction and liquid chromatography tandem mass spectrometry (SPE-LC/MS/MS). The advantage of this SPE-LC/MS/MS is its sensi...

Investigating crack sealant performance and causes of bumps in new hot mix asphalt overlays over crack sealants.

DOT National Transportation Integrated Search

2011-07-01

This final report is intended to provide information regarding the performance of crack sealants supplied and installed by : three manufacturers for experimental use in a three-year evaluation of in-service pavements on three Colorado highways. : In ...

Short-term crack sealant performance and reducing bumps and transverse cracking in new hot mix asphalt overlays over crack sealants.

DOT National Transportation Integrated Search

2009-11-01

This interim report is intended to provide preliminary information regarding the performance of crack sealants produced by three : manufacturers during a two-year period in service in three pavements in Colorado. In addition, preliminary conclusions ...

Physics in a Bouncing Car.

ERIC Educational Resources Information Center

Bartlett, Albert A.

1984-01-01

Defines frame of reference for the analysis of motion in a moving car, discussing the interaction of the car body, the seat springs, and the passenger when the car goes over a bump. Provides a related, but more advanced, problem with the motion of cars involving angular acceleration. (JM)

Origin and history of the Charleston Bump - Geological formations, currents, bottom conditions, and their relationship to wreckfish habitats on the Blake Plateau

USGS Publications Warehouse

Popenoe, P.; Manheim, F.T.

2001-01-01

The Charleston Bump is a structural and topographic high on the northern Blake Plateau that overlies a seaward offset of the edge of continental crust. The feature causes the bottom to shoal and deflects the Gulf Stream offshore, causing an intensification of bottom currents. The area has been swept by strong currents since late Cretaceous time, but the strongest currents have occurred in the Neogene (last ???25 million years). Nondepositional conditions prevail at present, but erosion of the bottom is checked where the bottom is armored by a hard surficial layer of phosphorite pavement. The phosphorite pavements were formed by re-cementation of eroded residues of phosphorite-rich sediments of early-Neogene age. In some places there are multiple pavements separated by poorly lithified sediments. Submersible observations indicate that the south, or current-facing flank of the Charleston Bump has several deep (>100 m) scour depressions, the southern flanks of which form cliffs characterized by ledges and overhangs. In other areas discrete layers of older Paleogene rocks have been partly eroded away, leaving cliff-like steps of 5 m or more relief. Conglomeratic phosphorite pavement layers up to 1 m thick armor most of the bottom. Where breached by scour, these pavements form both low-relief ledges and rock piles. These features form a reef-like environment of caves and overhangs utilized by wreckfish Polyprion americanus and barrelfish Hyperoglyphe perciformis as shelter from the current and as staging areas to prey on passing schools of squid. Wreckfish and other large fish were often localized in rugged bottom habitat, including caves and other shelter areas. We observed wreckfish darting from shelters to feed on passing schools of squid. Present and past observations, are consistent with the concept that impingement of the Gulf Stream at the Charleston Bump compresses midwater fauna from much thicker water layers, providing food for a flourishing big-fish fauna. During our dives we noted currents often exceeding 1 knot, and ranging to 2.4 knots. Evidence of fossil, manganese-iron-encrusted megaripples suggest even greater current regimes in the past. Investigation of the site of an earlier report of possible freshwater discharge failed to find any evidence of a closed sinkhole or freshwater discharge. Rather, we concluded that the apparent loss of buoyancy experienced by the submarine was probably caused by downward-directed eddy currents generated by currents sweeping across the pavement/void interface of a more than 100-m high cliff 3 km south of the reported location.

Spatiotemporal modelling of groundwater extraction in semi-arid central Queensland, Australia

NASA Astrophysics Data System (ADS)

Keir, Greg; Bulovic, Nevenka; McIntyre, Neil

2016-04-01

The semi-arid Surat Basin in central Queensland, Australia, forms part of the Great Artesian Basin, a groundwater resource of national significance. While this area relies heavily on groundwater supply bores to sustain agricultural industries and rural life in general, measurement of groundwater extraction rates is very limited. Consequently, regional groundwater extraction rates are not well known, which may have implications for regional numerical groundwater modelling. However, flows from a small number of bores are metered, and less precise anecdotal estimates of extraction are increasingly available. There is also an increasing number of other spatiotemporal datasets which may help predict extraction rates (e.g. rainfall, temperature, soils, stocking rates etc.). These can be used to construct spatial multivariate regression models to estimate extraction. The data exhibit complicated statistical features, such as zero-valued observations, non-Gaussianity, and non-stationarity, which limit the use of many classical estimation techniques, such as kriging. As well, water extraction histories may exhibit temporal autocorrelation. To account for these features, we employ a separable space-time model to predict bore extraction rates using the R-INLA package for computationally efficient Bayesian inference. A joint approach is used to model both the probability (using a binomial likelihood) and magnitude (using a gamma likelihood) of extraction. The correlation between extraction rates in space and time is modelled using a Gaussian Markov Random Field (GMRF) with a Matérn spatial covariance function which can evolve over time according to an autoregressive model. To reduce computational burden, we allow the GMRF to be evaluated at a relatively coarse temporal resolution, while still allowing predictions to be made at arbitrarily small time scales. We describe the process of model selection and inference using an information criterion approach, and present some preliminary results from the study area. We conclude by discussing issues related with upscaling of the modelling approach to the entire basin, including merging of extraction rate observations with different precision, temporal resolution, and even potentially different likelihoods.

Thermodynamic Bounds on Precision in Ballistic Multiterminal Transport

NASA Astrophysics Data System (ADS)

Brandner, Kay; Hanazato, Taro; Saito, Keiji

2018-03-01

For classical ballistic transport in a multiterminal geometry, we derive a universal trade-off relation between total dissipation and the precision, at which particles are extracted from individual reservoirs. Remarkably, this bound becomes significantly weaker in the presence of a magnetic field breaking time-reversal symmetry. By working out an explicit model for chiral transport enforced by a strong magnetic field, we show that our bounds are tight. Beyond the classical regime, we find that, in quantum systems far from equilibrium, the correlated exchange of particles makes it possible to exponentially reduce the thermodynamic cost of precision.

Reverse phase HPLC method for detection and quantification of lupin seed γ-conglutin.

PubMed

Mane, Sharmilee; Bringans, Scott; Johnson, Stuart; Pareek, Vishnu; Utikar, Ranjeet

2017-09-15

A simple, selective and accurate reverse phase HPLC method was developed for detection and quantitation of γ-conglutin from lupin seed extract. A linear gradient of water and acetonitrile containing trifluoroacetic acid (TFA) on a reverse phase column (Agilent Zorbax 300SB C-18), with a flow rate of 0.8ml/min was able to produce a sharp and symmetric peak of γ-conglutin with a retention time at 29.16min. The identity of γ-conglutin in the peak was confirmed by mass spectrometry (MS/MS identification) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. The data obtained from MS/MS analysis was matched against the specified database to obtain the exact match for the protein of interest. The proposed method was validated in terms of specificity, linearity, sensitivity, precision, recovery and accuracy. The analytical parameters revealed that the validated method was capable of selectively performing a good chromatographic separation of γ-conglutin from the lupin seed extract with no interference of the matrix. The detection and quantitation limit of γ-conglutin were found to be 2.68μg/ml and 8.12μg/ml respectively. The accuracy (precision and recovery) analysis of the method was conducted under repeatable conditions on different days. Intra-day and inter-day precision values less than 0.5% and recovery greater than 97% indicated high precision and accuracy of the method for analysis of γ-conglutin. The method validation findings were reproducible and can be successfully applied for routine analysis of γ-conglutin from lupin seed extract. Copyright © 2017 Elsevier B.V. All rights reserved.

Automatical and accurate segmentation of cerebral tissues in fMRI dataset with combination of image processing and deep learning

NASA Astrophysics Data System (ADS)

Kong, Zhenglun; Luo, Junyi; Xu, Shengpu; Li, Ting

2018-02-01

Image segmentation plays an important role in medical science. One application is multimodality imaging, especially the fusion of structural imaging with functional imaging, which includes CT, MRI and new types of imaging technology such as optical imaging to obtain functional images. The fusion process require precisely extracted structural information, in order to register the image to it. Here we used image enhancement, morphometry methods to extract the accurate contours of different tissues such as skull, cerebrospinal fluid (CSF), grey matter (GM) and white matter (WM) on 5 fMRI head image datasets. Then we utilized convolutional neural network to realize automatic segmentation of images in deep learning way. Such approach greatly reduced the processing time compared to manual and semi-automatic segmentation and is of great importance in improving speed and accuracy as more and more samples being learned. The contours of the borders of different tissues on all images were accurately extracted and 3D visualized. This can be used in low-level light therapy and optical simulation software such as MCVM. We obtained a precise three-dimensional distribution of brain, which offered doctors and researchers quantitative volume data and detailed morphological characterization for personal precise medicine of Cerebral atrophy/expansion. We hope this technique can bring convenience to visualization medical and personalized medicine.

Performance testing of NIOSH Method 5524/ASTM Method D-7049-04, for determination of metalworking fluids.

PubMed

Glaser, Robert; Kurimo, Robert; Shulman, Stanley

2007-08-01

A performance test of NIOSH Method 5524/ASTM Method D-7049-04 for analysis of metalworking fluids (MWF) was conducted. These methods involve determination of the total and extractable weights of MWF samples; extractions are performed using a ternary blend of toluene:dichloromethane:methanol and a binary blend of methanol:water. Six laboratories participated in this study. A preliminary analysis of 20 blank samples was made to familiarize the laboratories with the procedure(s) and to estimate the methods' limits of detection/quantitation (LODs/LOQs). Synthetically generated samples of a semisynthetic MWF aerosol were then collected on tared polytetrafluoroethylene (PTFE) filters and analyzed according to the methods by all participants. Sample masses deposited (approximately 400-500 micro g) corresponded to amounts expected in an 8-hr shift at the NIOSH recommended exposure levels (REL) of 0.4 mg/m(3) (thoracic) and 0.5 mg/m(3) (total particulate). The generator output was monitored with a calibrated laser particle counter. One laboratory significantly underreported the sampled masses relative to the other five labs. A follow-up study compared only gravimetric results of this laboratory with those of two other labs. In the preliminary analysis of blanks; the average LOQs were 0.094 mg for the total weight analysis and 0.136 mg for the extracted weight analyses. For the six-lab study, the average LOQs were 0.064 mg for the total weight analyses and 0.067 mg for the extracted weight analyses. Using ASTM conventions, h and k statistics were computed to determine the degree of consistency of each laboratory with the others. One laboratory experienced problems with precision but not bias. The precision estimates for the remaining five labs were not different statistically (alpha = 0.005) for either the total or extractable weights. For all six labs, the average fraction extracted was > or =0.94 (CV = 0.025). Pooled estimates of the total coefficients of variation of analysis were 0.13 for the total weight samples and 0.13 for the extracted weight samples. An overall method bias of -5% was determined by comparing the overall mean concentration reported by the participants to that determined by the particle counter. In the three-lab follow-up study, the nonconsistent lab reported results that were unbiased but statistically less precise than the others; the average LOQ was 0.133 mg for the total weight analyses. It is concluded that aerosolized MWF sampled at concentrations corresponding to either of the NIOSH RELs can generally be shipped unrefrigerated, stored refrigerated up to 7 days, and then analyzed quantitatively and precisely for MWF using the NIOSH/ASTM procedures.

Algorithms and semantic infrastructure for mutation impact extraction and grounding.

PubMed

Laurila, Jonas B; Naderi, Nona; Witte, René; Riazanov, Alexandre; Kouznetsov, Alexandre; Baker, Christopher J O

2010-12-02

Mutation impact extraction is a hitherto unaccomplished task in state of the art mutation extraction systems. Protein mutations and their impacts on protein properties are hidden in scientific literature, making them poorly accessible for protein engineers and inaccessible for phenotype-prediction systems that currently depend on manually curated genomic variation databases. We present the first rule-based approach for the extraction of mutation impacts on protein properties, categorizing their directionality as positive, negative or neutral. Furthermore protein and mutation mentions are grounded to their respective UniProtKB IDs and selected protein properties, namely protein functions to concepts found in the Gene Ontology. The extracted entities are populated to an OWL-DL Mutation Impact ontology facilitating complex querying for mutation impacts using SPARQL. We illustrate retrieval of proteins and mutant sequences for a given direction of impact on specific protein properties. Moreover we provide programmatic access to the data through semantic web services using the SADI (Semantic Automated Discovery and Integration) framework. We address the problem of access to legacy mutation data in unstructured form through the creation of novel mutation impact extraction methods which are evaluated on a corpus of full-text articles on haloalkane dehalogenases, tagged by domain experts. Our approaches show state of the art levels of precision and recall for Mutation Grounding and respectable level of precision but lower recall for the task of Mutant-Impact relation extraction. The system is deployed using text mining and semantic web technologies with the goal of publishing to a broad spectrum of consumers.

Fast microwave-assisted extraction of rotenone for its quantification in seeds of yam bean (Pachyrhizus sp.).

PubMed

Lautié, Emmanuelle; Rasse, Catherine; Rozet, Eric; Mourgues, Claire; Vanhelleputte, Jean-Paul; Quetin-Leclercq, Joëlle

2013-02-01

The aim of this study was to find if fast microwave-assisted extraction could be an alternative to the conventional Soxhlet extraction for the quantification of rotenone in yam bean seeds by SPE and HPLC-UV. For this purpose, an experimental design was used to determine the optimal conditions of the microwave extraction. Then the values of the quantification on three accessions from two different species of yam bean seeds were compared using the two different kinds of extraction. A microwave extraction of 11 min at 55°C using methanol/dichloromethane (50:50) allowed rotenone extraction either equivalently or more efficiently than the 8-h-Soxhlet extraction method and was less sensitive to moisture content. The selectivity, precision, trueness, accuracy, and limit of quantification of the method with microwave extraction were also demonstrated. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abbreviation definition identification based on automatic precision estimates.

PubMed

Sohn, Sunghwan; Comeau, Donald C; Kim, Won; Wilbur, W John

2008-09-25

The rapid growth of biomedical literature presents challenges for automatic text processing, and one of the challenges is abbreviation identification. The presence of unrecognized abbreviations in text hinders indexing algorithms and adversely affects information retrieval and extraction. Automatic abbreviation definition identification can help resolve these issues. However, abbreviations and their definitions identified by an automatic process are of uncertain validity. Due to the size of databases such as MEDLINE only a small fraction of abbreviation-definition pairs can be examined manually. An automatic way to estimate the accuracy of abbreviation-definition pairs extracted from text is needed. In this paper we propose an abbreviation definition identification algorithm that employs a variety of strategies to identify the most probable abbreviation definition. In addition our algorithm produces an accuracy estimate, pseudo-precision, for each strategy without using a human-judged gold standard. The pseudo-precisions determine the order in which the algorithm applies the strategies in seeking to identify the definition of an abbreviation. On the Medstract corpus our algorithm produced 97% precision and 85% recall which is higher than previously reported results. We also annotated 1250 randomly selected MEDLINE records as a gold standard. On this set we achieved 96.5% precision and 83.2% recall. This compares favourably with the well known Schwartz and Hearst algorithm. We developed an algorithm for abbreviation identification that uses a variety of strategies to identify the most probable definition for an abbreviation and also produces an estimated accuracy of the result. This process is purely automatic.

Simple, fast and reliable liquid chromatographic and spectrophotometric methods for the determination of theophylline in urine, saliva and plasma samples.

PubMed

Charehsaz, Mohammad; Gürbay, Aylin; Aydin, Ahmet; Sahin, Gönül

2014-01-01

In this study, a high-performance liquid chromatographic method (HPLC) and UV spectrophotometric method were developed, validated and applied for the determination of theophylline in biological fluids. Liquid- liquid extraction is performed for isolation of the drug and elimination of plasma and saliva interferences. Urine samples were applied without any extraction. The chromatographic separation was achieved on a C18 column by using 60:40 methanol:water as mobile phase under isocratic conditions at a flow rate of 0.75 mL/min with UV detection at 280 nm in HPLC method. UV spectrophotometric analysis was performed at 275 nm. the limit of quantification: 1.1 µg/mL for urine, 1.9 µg/mL for saliva, 3.1 µg/mL for plasma; recovery: 94.85% for plasma, 100.45% for saliva, 101.39% for urine; intra-day precision: 0.22-2.33%, inter-day precision: 3.17-13.12%. Spectrophotometric analysis results were as follows: the limit of quantitation: 5.23 µg/mL for plasma, 8.7 µg/mL for urine; recovery: 98.27% for plasma, 95.25% for urine; intra-day precision: 2.37 - 3.00%, inter-day precision: 5.43-7.91%. It can be concluded that this validated HPLC method is easy, precise, accurate, sensitive and selective for determination of theophylline in biological samples. Also spectrophotometric analysis can be used where it can be applicable.

Determination of cadmium in sediments by diluted HCI extraction and isotope dilution ICP-MS.

PubMed

Terán-Baamonde, Javier; Soto-Ferreiro, Rosa-María; Carlosena, Alatzne; Andrade, José-Manuel; Prada, Darío

2018-08-15

Isotope dilution ICP-MS is proposed to measure the mass fraction of Cd extracted by diluted HCl in marine sediments, using a fast and simple extraction procedure based on ultrasonic probe agitation. The 111 Cd isotope was added before the extraction to achieve isotope equilibration with native Cd solubilized from the sample. The parameters affecting trueness and precision of isotope ratio measurements were evaluated carefully and subsequently corrected in order to minimize errors; they were: detector dead time, spectral interferences, mass discrimination factor and optimum sample/spike ratio. The mass fraction of Cd extracted was compared with the sum of the certified contents of the three steps of the sequential extraction procedure of the Standards, Measurements and Testing Programme (SM&T) analysing the BCR 701 sediment to validate the method. The certified and measured values agreed, giving a measured / certified mass fraction ratio of 1.05. Further, the extraction procedure itself was studied by adding the enriched isotope after the extraction step, which allowed verifying that analyte losses occurred during this process. Two additional reference sediments with certified total cadmium contents were also analysed. The method provided very good precision (0.9%, RSD) and a low detection limit, 1.8 ng g -1 . The procedural uncertainty budget was estimated following the EURACHEM Guide by means of the 'GUM Workbench' software, obtaining a relative expanded uncertainty of 1.5%. The procedure was applied to determine the bioaccessible mass fraction of Cd in sediments from two environmentally and economically important areas of Galicia (rias of Arousa and Vigo, NW of Spain). Copyright © 2018 Elsevier B.V. All rights reserved.

Comparison of ASE and SFE with Soxhlet, Sonication, and Methanolic Saponification Extractions for the Determination of Organic Micropollutants in Marine Particulate Matter.

PubMed

Heemken, O P; Theobald, N; Wenclawiak, B W

1997-06-01

The methods of accelerated solvent extraction (ASE) and supercritical fluid extraction (SFE) of polycyclic aromatic hydrocarbons (PAHs), aliphatic hydrocarbons, and chlorinated hydrocarbons from marine samples were investigated. The results of extractions of a certified sediment and four samples of suspended particulate matter (SPM) were compared to classical Soxhlet (SOX), ultrasonication (USE), and methanolic saponification extraction (MSE) methods. The recovery data, including precision and systematic deviations of each method, were evaluated statistically. It was found that recoveries and precision of ASE and SFE compared well with the other methods investigated. Using SFE, the average recoveries of PAHs in three different samples ranged from 96 to 105%, for ASE the recoveries were in the range of 97-108% compared to the reference methods. Compared to the certified values of sediment HS-6, the average recoveries of SFE and ASE were 87 and 88%, most compounds being within the limits of confidence. Also, for alkanes the average recoveries by SFE and ASE were equal to the results obtained by SOX, USE, and MSE. In the case of SFE, the recoveries were in the range 93-115%, and ASE achieved recoveries of 94-107% as compared to the other methods. For ASE and SFE, the influence of water on the extraction efficiency was examined. While the natural water content of the SPM sample (56 wt %) led to insufficient recoveries in ASE and SFE, quantitative extractions were achieved in SFE after addition of anhydrous sodium sulfate to the sample. Finally, ASE was applied to SPM-loaded filter candles whereby a mixture of n-hexane/acetone as extraction solvent allowed the simultaneous determination of PAHs, alkanes, and chlorinated hydrocarbons.

Unlocking echocardiogram measurements for heart disease research through natural language processing.

PubMed

Patterson, Olga V; Freiberg, Matthew S; Skanderson, Melissa; J Fodeh, Samah; Brandt, Cynthia A; DuVall, Scott L

2017-06-12

In order to investigate the mechanisms of cardiovascular disease in HIV infected and uninfected patients, an analysis of echocardiogram reports is required for a large longitudinal multi-center study. A natural language processing system using a dictionary lookup, rules, and patterns was developed to extract heart function measurements that are typically recorded in echocardiogram reports as measurement-value pairs. Curated semantic bootstrapping was used to create a custom dictionary that extends existing terminologies based on terms that actually appear in the medical record. A novel disambiguation method based on semantic constraints was created to identify and discard erroneous alternative definitions of the measurement terms. The system was built utilizing a scalable framework, making it available for processing large datasets. The system was developed for and validated on notes from three sources: general clinic notes, echocardiogram reports, and radiology reports. The system achieved F-scores of 0.872, 0.844, and 0.877 with precision of 0.936, 0.982, and 0.969 for each dataset respectively averaged across all extracted values. Left ventricular ejection fraction (LVEF) is the most frequently extracted measurement. The precision of extraction of the LVEF measure ranged from 0.968 to 1.0 across different document types. This system illustrates the feasibility and effectiveness of a large-scale information extraction on clinical data. New clinical questions can be addressed in the domain of heart failure using retrospective clinical data analysis because key heart function measurements can be successfully extracted using natural language processing.

A linguistic rule-based approach to extract drug-drug interactions from pharmacological documents.

PubMed

Segura-Bedmar, Isabel; Martínez, Paloma; de Pablo-Sánchez, César

2011-03-29

A drug-drug interaction (DDI) occurs when one drug influences the level or activity of another drug. The increasing volume of the scientific literature overwhelms health care professionals trying to be kept up-to-date with all published studies on DDI. This paper describes a hybrid linguistic approach to DDI extraction that combines shallow parsing and syntactic simplification with pattern matching. Appositions and coordinate structures are interpreted based on shallow syntactic parsing provided by the UMLS MetaMap tool (MMTx). Subsequently, complex and compound sentences are broken down into clauses from which simple sentences are generated by a set of simplification rules. A pharmacist defined a set of domain-specific lexical patterns to capture the most common expressions of DDI in texts. These lexical patterns are matched with the generated sentences in order to extract DDIs. We have performed different experiments to analyze the performance of the different processes. The lexical patterns achieve a reasonable precision (67.30%), but very low recall (14.07%). The inclusion of appositions and coordinate structures helps to improve the recall (25.70%), however, precision is lower (48.69%). The detection of clauses does not improve the performance. Information Extraction (IE) techniques can provide an interesting way of reducing the time spent by health care professionals on reviewing the literature. Nevertheless, no approach has been carried out to extract DDI from texts. To the best of our knowledge, this work proposes the first integral solution for the automatic extraction of DDI from biomedical texts.

Development of a simultaneous multiple solid-phase microextraction-single shot-gas chromatography/mass spectrometry method and application to aroma profile analysis of commercial coffee.

PubMed

Lee, Changgook; Lee, Younghoon; Lee, Jae-Gon; Buglass, Alan J

2013-06-21

A simultaneous multiple solid-phase microextraction-single shot-gas chromatography mass spectrometry (smSPME-ss-GC/MS) method has been developed for headspace analysis. Up to four fibers (50/30 μm DVB/CAR/PDMS) were used simultaneously for the extraction of aroma components from the headspace of a single sample chamber in order to increase sensitivity of aroma extraction. To avoid peak broadening and to maximize resolution, a simple cryofocusing technique was adopted during sequential thermal desorption of multiple SPME fibers prior to a 'single shot' chromatographic run. The method was developed and validated on a model flavor mixture, containing 81 known pure components. With the conditions of 10 min of incubation and 30 min of extraction at 50 °C, single, dual, triple and quadruple SPME extractions were compared. The increase in total peak area with increase in the number of fibers showed good linearity (R(2)=0.9917) and the mean precision was 12.0% (RSD) for the total peak sum, with quadruple simultaneous SPME extraction. Using a real sample such as commercial coffee granules, aroma profile analysis was conducted using single, dual, triple and quadruple SPME fibers. The increase in total peak intensity again showed good linearity with increase in the number of SPME fibers used (R(2)=0.9992) and the precision of quadruple SPME extraction was 9.9% (RSD) for the total peak sum. Copyright © 2013 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Mingjian; Zhang, Jie; Feng, Cong

Here, one of the biggest concerns associated with integrating a large amount of renewable energy into the power grid is the ability to handle large ramps in the renewable power output. For the sake of system reliability and economics, it is essential for power system operators to better understand the ramping features of renewable, load, and netload. An optimized swinging door algorithm (OpSDA) is used and extended to accurately and efficiently detect ramping events. For wind power ramps detection, a process of merging 'bumps' (that have a different changing direction) into adjacent ramping segments is included to improve the performancemore » of the OpSDA method. For solar ramps detection, ramping events that occur in both clear-sky and measured (or forecasted) solar power are removed to account for the diurnal pattern of solar generation. Ramping features are extracted and extensively compared between load and netload under different renewable penetration levels (9.77%, 15.85%, and 51.38%). Comparison results show that (i) netload ramp events with shorter durations and smaller magnitudes occur more frequently when renewable penetration level increases, and the total number of ramping events also increases; and (ii) different ramping characteristics are observed in load and netload even with a low renewable penetration level.« less

Getting Goose Bumps about Teaching Evolution

ERIC Educational Resources Information Center

Foster, Collin

2014-01-01

Evolution offers an intellectually satisfying and extremely well-supported explanation for the diversity of life in the natural world, its similarities and differences, how changes occur and how new life forms have developed. There are plenty of reasons to anticipate the teaching of evolution with exhilaration. In recent years, the issue of…

Things That Go "Bump": in the Virtual Night.

ERIC Educational Resources Information Center

Fore, Julie A.

1997-01-01

Introduces concepts of server security and includes articles and sidebars of firsthand accounts of consequences of not devoting enough time to security measures. Outlines the following factors to consider when evaluating a server's risk potential: confidentiality/reproducibility of the data; complexity of the system; backup system and hardware…

The rideability of a deflected bridge approach slab (LTRC project 02-2GT continuation : phase II) : [tech summary].

DOT National Transportation Integrated Search

2014-10-01

DOTD has made attempts to use the standard international roughness index (IRI) to index bridge bumps. However, it was : discovered that IRI has problems indexing localized roughness. A research e ort was undertaken to investigate if there might : ...

Make It Stretch

ERIC Educational Resources Information Center

Ramaswami, Rama

2008-01-01

A K-12 educator traveling down the information superhighway will likely to hit some speed bumps. The biggest of those will be a lack of money. While legislators proclaim the need for 21st-century skills in education, federal funding for technology--the underwriter of those skills--is shrinking. According to the 2008 "National Trends"…

Moving toward a Culture of Inquiry

ERIC Educational Resources Information Center

Martin, Ralph

2010-01-01

In this paper, the author aims to share some of the efforts, successes, challenges and lessons learned over approximately two decades of professional development projects both large and small. In retrospect the author contends that efforts toward change, improvement and advancement were always bumping against culture. So, this address attempts to…

7 CFR 51.3154 - Well formed.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Well formed. 51.3154 Section 51.3154 Agriculture..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Nectarines Definitions § 51.3154 Well formed. “Well formed” means that the nectarine has the shape characteristic of the variety and that bumps or...

7 CFR 51.3154 - Well formed.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Well formed. 51.3154 Section 51.3154 Agriculture..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Nectarines Definitions § 51.3154 Well formed. “Well formed” means that the nectarine has the shape characteristic of the variety and that bumps or...

Say No to Speed Bumps!

ERIC Educational Resources Information Center

Brannon, Sian

2010-01-01

No matter how cutting edge (and nicely funded) one's library is, there is always something cooler and more efficient on the horizon. Granted, not all new technology may be necessary in the library. But chances are one is going to want to get something--RFID (radio frequency identification), text reference, downloadable content, gaming,…

75 FR 41921 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

... Confirmed Space AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation... Title: Report of passengers Denied Confirmed Space. Form No.: Form 251. Type Of Review: Re-instatement..., travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

77 FR 33808 - Agency Information Collection; Activity Under OMB Review: Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of.... SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0018 Title: Report of Passengers Denied Confirmed Space. Form... quarterly, travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

75 FR 21717 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of.... Title: Report of Passengers Denied Confirmed Space. Form No: BTS Form 251. Type of Review: Extension of..., travelers and travel agents can select carriers with lower incidences of bumping passengers. This...

49 CFR 219.5 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of being an employee for purposes of 49 U.S.C. 21106.) For the purposes of pre-employment testing..., or impact with a deliberately-placed obstruction such as a bumping post. The following are not impact..., selects that entity for performing tests under this part, or has a standing contractual relationship with...

49 CFR 219.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of being an employee for purposes of 49 U.S.C. 21106.) For the purposes of pre-employment testing..., or impact with a deliberately-placed obstruction such as a bumping post. The following are not impact..., selects that entity for performing tests under this part, or has a standing contractual relationship with...

49 CFR 219.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of being an employee for purposes of 49 U.S.C. 21106.) For the purposes of pre-employment testing..., or impact with a deliberately-placed obstruction such as a bumping post. The following are not impact..., selects that entity for performing tests under this part, or has a standing contractual relationship with...

Bumps in the Road: Expecting More Than Points on a Chart

ERIC Educational Resources Information Center

Hedrick, Wanda B.

2007-01-01

The behaviorist theory encourages educators to use rewards as teaching strategies. Extrinsic rewards eventually reduce intrinsic motivation, cheapen value and love of learning, give the wrong messages, and create an escalating no-win game. Three significant principles of motivation particularly important in fostering internal motivation for…

Autobiographical Memory from a Life Span Perspective

ERIC Educational Resources Information Center

Schroots, Johannes J. F.; van Dijkum, Cor; Assink, Marian H. J.

2004-01-01

This comparative study (i.e., three age groups, three measures) explores the distribution of retrospective and prospective autobiographical memory data across the lifespan, in particular the bump pattern of disproportionally higher recall of memories from the ages 10 to 30, as generally observed in older age groups, in conjunction with the…

Lumps, Bumps, and Things that Go Itch in Your Office!

ERIC Educational Resources Information Center

McLeod, Renee P.

2004-01-01

This article presents a short case presentation and differential diagnosis of impetigo, a common, contagious, superficial skin infection that is produced by streptococci, staphylococci, or a combination of both bacteria. There are two different clinical presentations: (1) bullous impetigo; and (2) nonbullous impetigo. For years, it was thought…

Small Colleges Expect Slight Enrollment Bump This Fall

ERIC Educational Resources Information Center

Beja, Marc

2009-01-01

Despite the continuing economic slump, enrollment at private, nonprofit colleges is expected to increase slightly this fall compared with last year, according to a report to be released this week by the National Association of Independent Colleges and Universities. Undergraduate enrollment is anticipated to grow by 0.2 percent, with combined…

Determination of d-limonene in adipose tissue by gas chromatography-mass spectrometry

PubMed Central

Miller, Jessica A.; Hakim, Iman A.; Thomson, Cynthia; Thompson, Patricia; Chow, H-H. Sherry

2008-01-01

We developed a novel method for analyzing d-limonene levels in adipose tissue. Fat samples were subjected to saponification followed by solvent extraction. d-Limonene in the sample extract was analyzed using gas chromatography-mass spectrometry (GC-MS) with selected ion monitoring. Linear calibration curves were established over the mass range of 79.0-2,529 ng d-limonene per 0.1 grams of adipose tissue. Satisfactory within day precision (RSD 6.7 to 9.6%) and accuracy (% difference of −2.7 to 3.8%) and between day precision (RSD 6.0 to 10.7%) and accuracy (% difference of 1.8 to 2.6%) were achieved. The assay was successfully applied to human fat biopsy samples from a d-limonene feeding trial. PMID:18571481

A cautionary tale: The Coulomb modified ANC for the 1/2+ 2 state in 17O

NASA Astrophysics Data System (ADS)

Keeley, N.; Kemper, K. W.; Rusek, K.

2018-05-01

We discuss the impact of the uncertainty (± 8 keV) in the excitation energy of the astrophysically important 6.356 MeV 1/2+2 state of 17O on the precision with which the Coulomb reduced ANC (\\widetilde{C}) for the < ^{17}O (1/2^+_2) | {}^{13}C + α> overlap can be extracted from direct reaction data. We find a linear dependence of \\widetilde{C}2 on the binding energy, the value extracted varying by a factor of 4 over the range E_{ex} = 6.356-6.348 MeV. This represents an intrinsic limit on the precision with which \\widetilde{C}2 can be determined which cannot be improved unless or until the uncertainty in E_{ex} is reduced.

Precision Measurement of the Neutron Twist-3 Matrix Element dn2: Probing Color Forces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Posik, Matthew; Flay, David; Parno, Diana

2014-07-01

Double-spin asymmetries and absolute cross sections were measured at large Bjorken x (0.25 lte x lte 0.90), in both the deep-inelastic and resonance regions, by scattering longitudinally polarized electrons at beam energies of 4.7 and 5.9 GeV from a transversely and longitudinally polarized 3He target. In this dedicated experiment, the spin structure function g2 on 3He was determined with precision at large x, and the neutron twist-three matrix element dn2 was measured at ?Q2? of 3.21 and 4.32 GeV2/c2, with an absolute precision of about 10?5. Our results are found to be in agreement with lattice QCD calculations and resolvemore » the disagreement found with previous data at ?Q2?= 5 GeV2/c2. Combining dn2 and a newly extracted twist-four matrix element, fn2, the average neutron color electric and magnetic forces were extracted and found to be of opposite sign and about 60 MeV/fm in magnitude.« less

A rapid assay for the simultaneous determination of nicotine, cocaine and metabolites in meconium using disposable pipette extraction and gas chromatography-mass spectrometry (GC-MS).

PubMed

Mozaner Bordin, Dayanne C; Alves, Marcela N R; Cabrices, Oscar G; de Campos, Eduardo G; De Martinis, Bruno Spinosa

2014-01-01

Drug abuse by pregnant women is considered a serious public health problem worldwide. Meconium is the first excretion in newborns and has been used as an alternative matrix to evaluate in utero drug exposure. Solid phase extraction (SPE) is widely employed to prepare and clean up samples in the field of forensic analysis. Most SPE products require large volumes of solvent, which culminates in longer sample processing times and increased cost per sample. Disposable pipette extraction (DPX) tips have been used as an alternative to traditional SPE cartridges. They combine efficient and rapid extraction with reduced solvent consumption. The purpose of this study was to develop and validate a method to determine nicotine, cotinine, cocaine, benzoylecgonine, cocaethylene and methyl ester anhydroecgonine in meconium using DPX and gas chromatography-mass spectrometry (GC-MS). Validation results indicated that extraction efficiency ranged 50-98%, accuracy 92-106%, intra-assay precision 4-12% and inter-assay precision 6-12%. Linear calibration curves resulted in R(2) values >0.99, limits of detection ranged from 2.5 to 15 ng/g and the limit of quantitation from 10 to 20 ng/g. The DPX-GC-MS method was shown to selectively analyze trace concentrations of drugs in meconium samples. Finally, the developed and validated method was applied to 50 meconium samples.

Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS.

PubMed

Masters, Andrea R; McCoy, Michael; Jones, David R; Desta, Zeruesenay

2016-03-15

Bupropion metabolites formed via oxidation and reduction exhibit pharmacological activity, but little is known regarding their stereoselective disposition. A novel stereoselective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to separate and quantify enantiomers of bupropion, 4-hydroxybupropion, and erythro- and threo-dihydrobupropion. Liquid-liquid extraction was implemented to extract all analytes from 50 μL human plasma. Acetaminophen (APAP) was used as an internal standard. The analytes were separated on a Lux 3 μ Cellulose-3 250×4.6 mm column by methanol: acetonitrile: ammonium bicarbonate: ammonium hydroxide gradient elution and monitored using an ABSciex 5500 QTRAP triple-quadrupole mass spectrometer equipped with electrospray ionization probe in positive mode. Extraction efficiency for all analytes was ≥70%. The stability at a single non-extracted concentration for over 48 h at ambient temperature resulted in less than 9.8% variability for all analytes. The limit of quantification (LOQ) for enantiomers of bupropion and 4-hydroxybupropion was 0.3 ng/mL, while the LOQ for enantiomers of erythro- and threo-hydrobupropion was 0.15 ng/mL. The intra-day precision and accuracy estimates for enantiomers of bupropion and its metabolites ranged from 3.4% to 15.4% and from 80.6% to 97.8%, respectively, while the inter-day precision and accuracy ranged from 6.1% to 19.9% and from 88.5% to 99.9%, respectively. The current method was successfully implemented to determine the stereoselective pharmacokinetics of bupropion and its metabolites in 3 healthy volunteers administered a single 100mg oral dose of racemic bupropion. This novel, accurate, and precise HPLC-MS/MS method should enhance further research into bupropion stereoselective metabolism and drug interactions. Copyright © 2016 Elsevier B.V. All rights reserved.

Automated Information Extraction on Treatment and Prognosis for Non-Small Cell Lung Cancer Radiotherapy Patients: Clinical Study.

PubMed

Zheng, Shuai; Jabbour, Salma K; O'Reilly, Shannon E; Lu, James J; Dong, Lihua; Ding, Lijuan; Xiao, Ying; Yue, Ning; Wang, Fusheng; Zou, Wei

2018-02-01

In outcome studies of oncology patients undergoing radiation, researchers extract valuable information from medical records generated before, during, and after radiotherapy visits, such as survival data, toxicities, and complications. Clinical studies rely heavily on these data to correlate the treatment regimen with the prognosis to develop evidence-based radiation therapy paradigms. These data are available mainly in forms of narrative texts or table formats with heterogeneous vocabularies. Manual extraction of the related information from these data can be time consuming and labor intensive, which is not ideal for large studies. The objective of this study was to adapt the interactive information extraction platform Information and Data Extraction using Adaptive Learning (IDEAL-X) to extract treatment and prognosis data for patients with locally advanced or inoperable non-small cell lung cancer (NSCLC). We transformed patient treatment and prognosis documents into normalized structured forms using the IDEAL-X system for easy data navigation. The adaptive learning and user-customized controlled toxicity vocabularies were applied to extract categorized treatment and prognosis data, so as to generate structured output. In total, we extracted data from 261 treatment and prognosis documents relating to 50 patients, with overall precision and recall more than 93% and 83%, respectively. For toxicity information extractions, which are important to study patient posttreatment side effects and quality of life, the precision and recall achieved 95.7% and 94.5% respectively. The IDEAL-X system is capable of extracting study data regarding NSCLC chemoradiation patients with significant accuracy and effectiveness, and therefore can be used in large-scale radiotherapy clinical data studies. ©Shuai Zheng, Salma K Jabbour, Shannon E O'Reilly, James J Lu, Lihua Dong, Lijuan Ding, Ying Xiao, Ning Yue, Fusheng Wang, Wei Zou. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 01.02.2018.

Electrothermal atomisation atomic absorption conditions and matrix modifications for determining antimony, arsenic, bismuth, cadmium, gallium, gold, indium, lead, molybdenum, palladium, platinum, selenium, silver, tellurium, thallium and tin following back-extraction of organic aminohalide extracts

USGS Publications Warehouse

Clark, J.R.

1986-01-01

A multi-element organic-extraction and back-extraction procedure, that had been developed previously to eliminate matrix interferences in the determination of a large number of trace elements in complex materials such as geological samples, produced organic and aqueous solutions that were complex. Electrothermal atomisation atomic absorption conditions and matrix modifications have been developed for 13 of the extracted elements (Ag, As, Au, Bi, Cd, Ga, In, Pb, Sb, Se, Sn, Te and Tl) that enhance sensitivity, alleviate problems resulting from the complex solutions and produce acceptable precision. Platinum, Pd and Mo can be determined without matrix modification directly on the original unstripped extracts.

Analysis of drugs in human tissues by supercritical fluid extraction/immunoassay

NASA Astrophysics Data System (ADS)

Furton, Kenneth G.; Sabucedo, Alberta; Rein, Joseph; Hearn, W. L.

1997-02-01

A rapid, readily automated method has been developed for the quantitative analysis of phenobarbital from human liver tissues based on supercritical carbon dioxide extraction followed by fluorescence enzyme immunoassay. The method developed significantly reduces sample handling and utilizes the entire liver homogenate. The current method yields comparable recoveries and precision and does not require the use of an internal standard, although traditional GC/MS confirmation can still be performed on sample extracts. Additionally, the proposed method uses non-toxic, inexpensive carbon dioxide, thus eliminating the use of halogenated organic solvents.

An Improved Method of AGM for High Precision Geolocation of SAR Images

NASA Astrophysics Data System (ADS)

Zhou, G.; He, C.; Yue, T.; Huang, W.; Huang, Y.; Li, X.; Chen, Y.

2018-05-01

In order to take full advantage of SAR images, it is necessary to obtain the high precision location of the image. During the geometric correction process of images, to ensure the accuracy of image geometric correction and extract the effective mapping information from the images, precise image geolocation is important. This paper presents an improved analytical geolocation method (IAGM) that determine the high precision geolocation of each pixel in a digital SAR image. This method is based on analytical geolocation method (AGM) proposed by X. K. Yuan aiming at realizing the solution of RD model. Tests will be conducted using RADARSAT-2 SAR image. Comparing the predicted feature geolocation with the position as determined by high precision orthophoto, results indicate an accuracy of 50m is attainable with this method. Error sources will be analyzed and some recommendations about improving image location accuracy in future spaceborne SAR's will be given.

Precise Near IR Radial Velocity First Light Observations With iSHELL

NASA Astrophysics Data System (ADS)

Cale, Bryson L.; Plavchan, Peter; Gagné, Jonathan; Gao, Peter; Nishimoto, America; Tanner, Angelle; Walp, Bernie; Brinkworth, Carolyn; Johnson, John Asher; Vasisht, Gautam

2018-01-01

We present our current progress on obtaining precise radial velocities with the new iSHELL spectrograph at NASA's Infrared Telescope Facility. To obtain precise RV's, we use a methane isotopologue absorption gas cell in the calibration unit. Over the past year, we've collected 3-12 epochs of 17 bright G, K, and M dwarfs at a high SNR. By focusing on late type type stars, we obtain relatively higher SNR in the near infrared. We've successfully updated both our spectral and RV extraction pipelines, with a few exceptions. Inherent to the iSHELL data is a wavelength dependent fringing component, which must be incorporated into our model to obtain adequate RV precision. With iSHELL's predecessor, CSHELL, we obtained a precision of 3 m/s on the bright M giant SV Peg. With further progress on our fringing and telluric models, we hope to obtain a precision of <3 m/s with iSHELL, sufficient to detect terrestrial planets in the habitable zone of nearby M dwarfs.

Precision Medicine and Men's Health.

PubMed

Mata, Douglas A; Katchi, Farhan M; Ramasamy, Ranjith

2017-07-01

Precision medicine can greatly benefit men's health by helping to prevent, diagnose, and treat prostate cancer, benign prostatic hyperplasia, infertility, hypogonadism, and erectile dysfunction. For example, precision medicine can facilitate the selection of men at high risk for prostate cancer for targeted prostate-specific antigen screening and chemoprevention administration, as well as assist in identifying men who are resistant to medical therapy for prostatic hyperplasia, who may instead require surgery. Precision medicine-trained clinicians can also let couples know whether their specific cause of infertility should be bypassed by sperm extraction and in vitro fertilization to prevent abnormalities in their offspring. Though precision medicine's role in the management of hypogonadism has yet to be defined, it could be used to identify biomarkers associated with individual patients' responses to treatment so that appropriate therapy can be prescribed. Last, precision medicine can improve erectile dysfunction treatment by identifying genetic polymorphisms that regulate response to medical therapies and by aiding in the selection of patients for further cardiovascular disease screening.

Convolutional neural network for road extraction

NASA Astrophysics Data System (ADS)

Li, Junping; Ding, Yazhou; Feng, Fajie; Xiong, Baoyu; Cui, Weihong

2017-11-01

In this paper, the convolution neural network with large block input and small block output was used to extract road. To reflect the complex road characteristics in the study area, a deep convolution neural network VGG19 was conducted for road extraction. Based on the analysis of the characteristics of different sizes of input block, output block and the extraction effect, the votes of deep convolutional neural networks was used as the final road prediction. The study image was from GF-2 panchromatic and multi-spectral fusion in Yinchuan. The precision of road extraction was 91%. The experiments showed that model averaging can improve the accuracy to some extent. At the same time, this paper gave some advice about the choice of input block size and output block size.

Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery.

PubMed

Gonzalez, Graciela H; Tahsin, Tasnia; Goodale, Britton C; Greene, Anna C; Greene, Casey S

2016-01-01

Precision medicine will revolutionize the way we treat and prevent disease. A major barrier to the implementation of precision medicine that clinicians and translational scientists face is understanding the underlying mechanisms of disease. We are starting to address this challenge through automatic approaches for information extraction, representation and analysis. Recent advances in text and data mining have been applied to a broad spectrum of key biomedical questions in genomics, pharmacogenomics and other fields. We present an overview of the fundamental methods for text and data mining, as well as recent advances and emerging applications toward precision medicine. © The Author 2015. Published by Oxford University Press.

Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery

PubMed Central

Gonzalez, Graciela H.; Tahsin, Tasnia; Goodale, Britton C.; Greene, Anna C.

2016-01-01

Precision medicine will revolutionize the way we treat and prevent disease. A major barrier to the implementation of precision medicine that clinicians and translational scientists face is understanding the underlying mechanisms of disease. We are starting to address this challenge through automatic approaches for information extraction, representation and analysis. Recent advances in text and data mining have been applied to a broad spectrum of key biomedical questions in genomics, pharmacogenomics and other fields. We present an overview of the fundamental methods for text and data mining, as well as recent advances and emerging applications toward precision medicine. PMID:26420781