Science.gov

Sample records for bumps precision extraction

  1. Procedures For Making Precision CH Bumps On Capsules

    SciTech Connect

    Letts, S; Fearon, E; Buckley, S; Klingmann, J; Cook, B

    2004-11-10

    Recently we were asked to produce target capsules with bumps on the surface. The bumps were to test the effects of fill tubes in future targets. The bumps desired were to be Gaussian in shape and from 60 to 40 {micro}m in diameter and from 1 to 6 {micro}m high. The capsules had a nominal diameter of 500 {micro}m. The approach we used was to align a precision aperture to the capsule and coat through the aperture onto the capsule surface using plasma polymer coating. The bumps were characterized using optical microscopy, Wyko interferometry, and AFM sphere mapping.

  2. NSRL Extraction Bump Control in the Booster

    SciTech Connect

    Brennan,L.

    2008-10-01

    Due to inadequacies in the user interface of the booster orbit control system, a number of new tools were developed. The first priority was an accurate calculation of the winding currents given specific displacements at each extraction septa. Next, the physical limits of the power supplies ({+-}600 amps) needed to be taken into account. In light of this limit, a system is developed that indicates to the user what the allowed values of one bump parameter are once the other two have been specified. Finally, techniques are developed to account for the orbit behavior once power supplies are requested to exceed their {+-}600 amp limit. This includes a recalculation of bump parameters and a calculation of the amplitude of the residuals. Following this, possible areas for further development are outlined. These techniques were computationally developed in Mathematica and tested in the Methodical Accelerator Design (MAD) program before they were implemented into the control system. At the end, a description of the implementation of these techniques in a new interface is described. This includes a depiction of the appearance and functionality of the graphical user interface, a description of the input and output flow, and an outline of how each important calculation is performed.

  3. Apparatus for Precise Indium-Bump Bonding of Microchips

    NASA Technical Reports Server (NTRS)

    Wild, Larry; Mulder, Jerry; Alvarado, Nicholas

    2005-01-01

    An improved apparatus has been designed and built for use in precise positioning and pressing of a microchip onto a substrate (which could, optionally, be another microchip) for the purpose of indium-bump bonding. The apparatus (see figure) includes the following: A stereomicroscope, A stage for precise positioning of the microchip in rotation angle (theta) about the nominally vertical pressing axis and in translation along two nominally horizontal coordinate axes (x and y), and An actuator system that causes a bonding tip to press the microchip against the substrate with a precisely controlled force. In operation, the microscope and the stage are used to position the microchip under the bonding tip and to align the indium bumps on the chip and the substrate, then the actuator system is used to apply a prescribed bonding force for a prescribed time. The improved apparatus supplants a partly similar prior apparatus that operated with less precision and repeatability, producing inconsistent and unreliable bonds. Results of the use of the prior apparatus included broken microchips, uneven bonds, and bonds characterized, variously, by overcompression or undercompression. In that apparatus, the bonding force was generated and controlled by use of a micrometer head positioned over the center of a spring-loaded scale, and the force was applied to the microchip via the scale, which was equipped for digital readout of the force. The inconsistency of results was attributed to the following causes: It was not possible to control the bonding force with sufficient precision or repeatability. Particularly troublesome was the inability to control the force at levels less than the weight of 150 g. Excessive compliance in the spring-loaded scale, combined with deviations from parallelarity of the substrate and bonding-tip surfaces, gave rise to nonuniformity in the pressure applied to the microchip, thereby generating excessive stresses and deformations in the microchip. In the

  4. Controlling coal mine bumps

    SciTech Connect

    Goode, C.A.; Campoli, A.A.; Zona, A.

    1984-10-01

    A coal bump or burst is defined as the instantaneous violent failure of a coal pillar(s) from overstress. The causes of coal bumps are not well understood, even though minor disturbances are a daily occurrence in bump prone seams. Lack of knowledge about coal bumps coupled with questionable mining practices can create disastrous consequences. Much of the early work on bumps was documented by US Bureau of Mines (BOM) researchers and operators of mines prone to bumps. In 1954 the BOM published Bulletin 535, This study compares recent events with those findings and suggests measures that can be taken to minimize the potential occurrence and severity of coal bumps.

  5. Creep characterization of solder bumps using nanoindentation

    NASA Astrophysics Data System (ADS)

    Du, Yingjie; Liu, Xiao Hu; Fu, Boshen; Shaw, Thomas M.; Lu, Minhua; Wassick, Thomas A.; Bonilla, Griselda; Lu, Hongbing

    2016-10-01

    Current nanoindentation techniques for the measurement of creep properties are applicable to viscoplastic materials with negligible elastic deformations. A new technique for characterization of creep behavior is needed for situations where the elastic deformation plays a significant role. In this paper, the effect of elastic deformation on the determination of creep parameters using nanoindentation with a self-similar nanoindenter tip is evaluated using finite element analysis (FEA). It is found that the creep exponent measured from nanoindentation without taking into account of the contribution of elastic deformation tends to be higher than the actual value. An effective correction method is developed to consider the elastic deformation in the calculation of creep parameters. FEA shows that this method provides accurate creep exponent. The creep parameters, namely the creep exponent and activation energy, were measured for three types of reflowed solder bumps using the nanoindentation method. The measured parameters were verified using FEA. The results show that the new correction approach allows extraction of creep parameters with precision from nanoindentation data.

  6. Optimization of Indium Bump Morphology for Improved Flip Chip Devices

    NASA Technical Reports Server (NTRS)

    Jones, Todd J.; Nikzad, Shouleh; Cunningham, Thomas J.; Blazejewski, Edward; Dickie, Matthew R.; Hoenk, Michael E.; Greer, Harold F.

    2011-01-01

    Flip-chip hybridization, also known as bump bonding, is a packaging technique for microelectronic devices that directly connects an active element or detector to a substrate readout face-to-face, eliminating the need for wire bonding. In order to make conductive links between the two parts, a solder material is used between the bond pads on each side. Solder bumps, composed of indium metal, are typically deposited by thermal evaporation onto the active regions of the device and substrate. While indium bump technology has been a part of the electronic interconnect process field for many years and has been extensively employed in the infrared imager industry, obtaining a reliable, high-yield process for high-density patterns of bumps can be quite difficult. Under the right conditions, a moderate hydrogen plasma exposure can raise the temperature of the indium bump to the point where it can flow. This flow can result in a desirable shape where indium will efficiently wet the metal contact pad to provide good electrical contact to the underlying readout or imager circuit. However, it is extremely important to carefully control this process as the intensity of the hydrogen plasma treatment dramatically affects the indium bump morphology. To ensure the fine-tuning of this reflow process, it is necessary to have realtime feedback on the status of the bumps. With an appropriately placed viewport in a plasma chamber, one can image a small field (a square of approximately 5 millimeters on each side) of the bumps (10-20 microns in size) during the hydrogen plasma reflow process. By monitoring the shape of the bumps in real time using a video camera mounted to a telescoping 12 magnifying zoom lens and associated optical elements, an engineer can precisely determine when the reflow of the bumps has occurred, and can shut off the plasma before evaporation or de-wetting takes place.

  7. Precision of the CAESAR scan-extracted measurements.

    PubMed

    Robinette, Kathleen M; Daanen, Hein A M

    2006-05-01

    Three-dimensional (3D) body scanners are increasingly used to derive 1D body dimensions from 3D whole body scans for instance, as input for clothing grading systems to make made-to-measure clothing or for width and depth dimensions of a seated workstation. In this study, the precision of the scanner-derived 1D dimensions from the CAESAR survey, a multinational anthropometric survey, was investigated. Two combinations of scanning teams with 3D whole body scanners were compared, one called the US Team and the other the Dutch Team. Twenty subjects were measured three times by one scanner and one team, and three times by the other combination. The subjects were marked prior to scanning using small dots, and the linear distances between the dots were calculated after processing the scans. The mean absolute difference (MAD) of the repetitions was calculated and this was compared to reported acceptable errors in manual measurements from the US Army's ANSUR survey when similar measurements were available. In addition, the coefficient of variation (CV) was calculated for all measurements. The results indicate that the CAESAR scan-extracted measurements are highly reproducible; for most measures the MAD is less than 5mm. In addition, more than 93% of the MAD values for CAESAR are significantly smaller than the ANSUR survey acceptable errors. Therefore, it is concluded that the type of scan-extracted measures used in CAESAR are as good as or better than comparable manual measurements. Scan-extracted measurements that do not use markers or are not straight-line distances are not represented here and additional studies would be needed to verify their precision.

  8. Study of bump bonding technology

    SciTech Connect

    Selcuk Cihangir et al.

    2003-10-17

    Pixel detectors proposed for the new generation of hadron collider experiments will use bump-bonding technology based on either indium or Pb/Sn solder to connect the front-end readout chips to the silicon pixel sensors. We have previously reported large-scale tests of the yield using both indium and Pb/Sn solder bump [1]. The conclusion is that both seem to be viable for pixel detectors. We have also carried out studies of various effects (e.g. storage over long period, effect of heating and cooling, and radiation) on both types of bump bonds using daisy-chained parts on a small scale [2], [3]. Overall, these tests showed little changes in the integrity of the bump connections. Nevertheless, questions still remain on the long-term reliability of the bumps due to thermal cycle effects, attachment to a substrate with a different coefficient of thermal expansion (CTE), and radiation.

  9. The bumps on the hippocampus

    NASA Astrophysics Data System (ADS)

    Gao, Yi; Ver Hoef, Lawrence

    2016-03-01

    The hippocampus has been the focus of more imaging research than any other subcortical structure in the human brain. However a feature that has been almost universally overlooked are the bumpy ridges on the inferior aspect of the hippocampus, which we refer to as hippocampal dentation. These bumps arise from folds in the CA1 layer of Ammon's horn. Similar to the folding of the cerebral cortex, hippocampal dentation allows for greater surface area in a confined space. However, while quantitative studies of radiologic brain images have been advancing for decades, examining numerous approaches to hippocampal segmentation and morphology analysis, virtually all published 3D renderings of the hippocampus show the under surface to be quite smooth or mildly irregular; we have rarely seen the characteristic bumpy structure in the reconstructed 3D scene, one exception being the 9.4T postmortem study. This is presumably due to the fact that, based on our experience with high resolution images, there is a dramatic degree of variability in hippocampal dentation between individuals from very smooth to highly dentated. An apparent question is, does this indicate that this specific morphological signature can only be captured using expensive ultra-high field techniques? Or, is such information buried in the data we commonly acquire, awaiting a computation technique that can extract and render it clearly? In this study, we propose a super-resolution technique that captures the fine scale morphometric features of the hippocampus based on common T1-weighted 3T MR images.

  10. Beam Based Calibration of Slow Orbit Bump in the NSLS Booster

    SciTech Connect

    Yang, X.; Shaftan, T.; Rose, J.

    2009-05-04

    The orbit bumps in NSLS booster are used to move the beam orbit within 2mm of the extraction septum aperture on a time scale of millisecond at extraction in order to reduce the requirement on the amplitude of the fast extraction kicker. This may cause charge losses since before extraction, the beam stays on the distorted orbit for thousands of revolutions. In order to find the optimal orbit bump setpoint, which brings the maximum distortion at the extraction position and minimum distortions everywhere else, we developed an extraction model and performed an experiment to validate it. Afterwards, the model was applied to optimize the extraction process.

  11. Using active thermography and modified SVM for intelligent diagnosis of solder bumps

    NASA Astrophysics Data System (ADS)

    Wei, Wei; Wei, Li; Nie, Lei; Su, Lei; Lu, Xiangning

    2015-09-01

    Solder bump technology has been used extensively in microelectronic packaging. But defect inspection becomes increasingly difficult due to the decrease of solder bumps in dimension and pitch. To overcome the shortages of traditional methods, we have developed an intelligent system using the active thermography for defects inspection of the solder bumps. A modified support vector machine (M-SVM) was investigated to solve the problem of small sample size in solder bumps classification. The chip SFA1 and SFA2 were chosen as the test vehicles. Captured thermal images were preprocessed using the improved wiener filter and moving average technique to remove the peak noise. The principal component analysis (PCA) algorithm was then adopted to reconstruct the thermal image, in which the hot spots were segmented. The statistical features corresponding to every solder bump were extracted and input into the M-SVM for solder bumps classification. The defective bumps w distinguished from the good bumps, which proves that the intelligent system using the modified SVM is effective for defects inspection in microelectronic packages.

  12. Condensation on Slippery Asymmetric Bumps

    NASA Astrophysics Data System (ADS)

    Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna

    Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.

  13. Condensation on Slippery Asymmetric Bumps

    NASA Astrophysics Data System (ADS)

    Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna

    2016-11-01

    Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.

  14. Process for Patterning Indium for Bump Bonding

    NASA Technical Reports Server (NTRS)

    Denis, Kevin

    2012-01-01

    An innovation was created for the Cosmology Large Angular Scale Surveyor for integration of low-temperature detector chips with a silicon backshort and a silicon photonic choke through flipchip bonding. Indium bumps are typically patterned using liftoff processes, which require thick resist. In some applications, it is necessary to locate the bumps close to high-aspect-ratio structures such as wafer through-holes. In those cases, liftoff processes are challenging, and require complicated and time-consuming spray coating technology if the high-aspect-ratio structures are delineated prior to the indium bump process. Alternatively, processing the indium bumps first is limited by compatibility of the indium with subsequent processing. The present invention allows for locating bumps arbitrarily close to multiple-level high-aspect-ratio structures, and for indium bumps to be formed without liftoff resist. The process uses the poor step coverage of indium deposited on a silicon wafer that has been previously etched to delineate the location of the indium bumps. The silicon pattern can be processed through standard lithography prior to adding the high-aspect-ratio structures. Typically, high-aspectratio structures require a thick resist layer so this layer can easily cover the silicon topography. For multiple levels of topography, the silicon can be easily conformally coated through standard processes. A blanket layer of indium is then deposited onto the full wafer; bump bonding only occurs at the high points of the topography.

  15. Haglund syndrome with pump bump.

    PubMed

    Kucuksen, Sami; Karahan, Ali Yavuz; Erol, Kemal

    2012-01-01

    Haglund's syndrome, which is an inflammation of the bursa and a bony enlargement on the back of the heel that most often leads to painful bursitis, is a rare cause of retrocalcaneal pain. The clinical diagnosis is often confusing as the clinical picture may mimic other causes of hindfoot pain such as isolated retrocalcaneal bursitis or hindfoot involvement from more systemic disorders such as seronegative spondyloarthropathies (Reiter's syndrome, ankylosing spondylitis) or rheumatoid arthritis. This report is of a 60-year-old woman with a painful swelling of the right heel, who was diagnosed with Haglund syndrome. The characteristic clinical photograph (showing the prominent 'pump bump'), radiographical and magnetic resonance imaging features are presented.

  16. Condensation on slippery asymmetric bumps.

    PubMed

    Park, Kyoo-Chul; Kim, Philseok; Grinthal, Alison; He, Neil; Fox, David; Weaver, James C; Aizenberg, Joanna

    2016-03-03

    Controlling dropwise condensation is fundamental to water-harvesting systems, desalination, thermal power generation, air conditioning, distillation towers, and numerous other applications. For any of these, it is essential to design surfaces that enable droplets to grow rapidly and to be shed as quickly as possible. However, approaches based on microscale, nanoscale or molecular-scale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach--based on principles derived from Namib desert beetles, cacti, and pitcher plants--that synergistically combines these aspects of condensation and substantially outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bumpy surface geometry in promoting condensation, and using theoretical modelling, we show how to maximize vapour diffusion fluxat the apex of convex millimetric bumps by optimizing the radius of curvature and cross-sectional shape. Integrating this apex geometry with a widening slope, analogous to cactus spines, directly couples facilitated droplet growth with fast directional transport, by creating a free-energy profile that drives the droplet down the slope before its growth rate can decrease. This coupling is further enhanced by a slippery, pitcher-plant-inspired nanocoating that facilitates feedback between coalescence-driven growth and capillary-driven motion on the way down. Bumps that are rationally designed to integrate these mechanisms are able to grow and transport large droplets even against gravity and overcome the effect of an unfavourable temperature gradient. We further observe an unprecedented sixfold-higher exponent of growth rate, faster onset, higher steady-state turnover rate, and a greater volume of water collected compared to other surfaces. We envision that this fundamental understanding and rational design strategy can be

  17. Condensation on slippery asymmetric bumps

    NASA Astrophysics Data System (ADS)

    Park, Kyoo-Chul; Kim, Philseok; Grinthal, Alison; He, Neil; Fox, David; Weaver, James C.; Aizenberg, Joanna

    2016-03-01

    Controlling dropwise condensation is fundamental to water-harvesting systems, desalination, thermal power generation, air conditioning, distillation towers, and numerous other applications. For any of these, it is essential to design surfaces that enable droplets to grow rapidly and to be shed as quickly as possible. However, approaches based on microscale, nanoscale or molecular-scale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach—based on principles derived from Namib desert beetles, cacti, and pitcher plants—that synergistically combines these aspects of condensation and substantially outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle’s bumpy surface geometry in promoting condensation, and using theoretical modelling, we show how to maximize vapour diffusion fluxat the apex of convex millimetric bumps by optimizing the radius of curvature and cross-sectional shape. Integrating this apex geometry with a widening slope, analogous to cactus spines, directly couples facilitated droplet growth with fast directional transport, by creating a free-energy profile that drives the droplet down the slope before its growth rate can decrease. This coupling is further enhanced by a slippery, pitcher-plant-inspired nanocoating that facilitates feedback between coalescence-driven growth and capillary-driven motion on the way down. Bumps that are rationally designed to integrate these mechanisms are able to grow and transport large droplets even against gravity and overcome the effect of an unfavourable temperature gradient. We further observe an unprecedented sixfold-higher exponent of growth rate, faster onset, higher steady-state turnover rate, and a greater volume of water collected compared to other surfaces. We envision that this fundamental understanding and rational design strategy can be

  18. High-precision simulation of slow-extraction spill from a hadrontherapy synchrotron

    NASA Astrophysics Data System (ADS)

    Méot, F.

    2008-10-01

    This report reviews the reconstruction, by means of multiturn, stepwise ray-tracing, of a slow-extracted particle beam from a synchrotron. The goal is to show that very precise descriptions of the transverse beam densities and the slow-spill intensity, which are crucial parameters in hadrontherapy, can be obtained in this way.

  19. Precision and Selection of Extraction Methods of Aphelenchid Nematodes from Maritime Pine Wood, Pinus pinaster L.

    PubMed Central

    Penas, Ana C.; DIias, Luis S.; Mota, Manuel M.

    2002-01-01

    Four extraction methods for Bursaphelenchus xylophilus and other aphelenchid nematodes were compared on the number of nematodes per gram recovered, and on the precision of the mean number of nematodes per gram of pine wood. The number of nematodes per gram recovered by each method, in addition to its inherent shortcomings when the actual number of nematodes is unknown, failed to provide clear rankings among the extraction methods. The precision of the mean number of nematodes per gram did provide clear guidelines for selection. Selection of the method may be based on prior knowledge about the range of nematodes to be expected or the independence of precision from the mean number of nematodes. PMID:19265909

  20. TRACKING TESTS FOR THE SNS FAST INJECTION BUMP POWER SUPPLY

    SciTech Connect

    ENG,W.CUTLER,R.DEWAN,S.ET AL.

    2004-07-05

    The tracking requirement of the SNS Fast Injection Bump power supplies is described. In addition to the usual tracking between the load current and the input reference of a power supply, these power supplies must also track between pairs of units under slightly different loads. This paper describes the use of a current-null test to measure tracking performances. For the actual tests, a single dummy magnet load was used to measure the tracking between the first two production units at the manufacturer's facility. Using the Yokogawa WE7000 waveform. PC-based measurement instrument, input and output waveforms are digitized and stored in data files. A program written for this application is then used to extract data from these files to construct, analyze the waveforms and characterize the power supply performance. Results of the measurements of two SNS Fast Injection Bump power supplies will be presented in this paper.

  1. Single Bump on a Shell Fabrication

    SciTech Connect

    Cook, R C

    2004-02-17

    At this morning's fill-tube surrogate working group meeting we tentatively decided on a single bump on a shell for the single March shot. This memo shows the calculations needed as background to fabricate such a bump by depositing an appropriate sized drop of polystyrene solution (i.e. the glue) to a shell as discussed in this mornings meeting. While writing this I had another idea for fabricating a bump, which I quickly outlined at the end of this memo. I am distributing this calculation primarily so that group members can quickly check the calculations and ideas and if without error to provide a framework for initial fabrication efforts.

  2. Bumps in Small-World Networks

    PubMed Central

    Laing, Carlo R.

    2016-01-01

    We consider a network of coupled excitatory and inhibitory theta neurons which is capable of supporting stable spatially-localized “bump” solutions. We randomly add long-range and simultaneously remove short-range connections within the network to form a small-world network and investigate the effects of this rewiring on the existence and stability of the bump solution. We consider two limits in which continuum equations can be derived; bump solutions are fixed points of these equations. We can thus use standard numerical bifurcation analysis to determine the stability of these bumps and to follow them as parameters (such as rewiring probabilities) are varied. We find that under some rewiring schemes bumps are quite robust, whereas in other schemes they can become unstable via Hopf bifurcation or even be destroyed in saddle-node bifurcations. PMID:27378897

  3. Computer tomography-based precision inspection and shape extraction using facet model

    NASA Astrophysics Data System (ADS)

    Wang, Wenjian; Wu, Xiaogu; Wee, William G.

    2000-01-01

    We apply the facet mode to extract edge and surface information from computed tomography (CT) images for precision inspection and shape extraction. First we explore the application of the facet model in a 3D filter design. A 3D directional-derivative-based surface detector is developed to extract surface points from the CT images. Subpixel accuracy is achieved by locating the zeros of the 3D second directional derivative along the estimated gradient direction. Then we develop a precision inspection system to take turbine blade wall width measurements from CT images and compare them to the corresponding optical measurements. Least mean squares methods are used to enhance prediction accuracy with the adaptive property of increasing accuracy when additional variable data are available. The system accuracy is within 3 mil. Unverified measurements are adjusted based on the verified measurements, and experiments show increasing accuracy of the adjusted measurements as additional verified measurements are available. Also, quantitative analysis of a trapezoid-shaped workpiece is performed. The results indicate that the CT system performance is affected by the structure and size of a workpiece. We also present an algorithm to extract 3D shapes from detected surface points interactively and use them for visual inspection.

  4. Precise on-machine extraction of the surface normal vector using an eddy current sensor array

    NASA Astrophysics Data System (ADS)

    Wang, Yongqing; Lian, Meng; Liu, Haibo; Ying, Yangwei; Sheng, Xianjun

    2016-11-01

    To satisfy the requirements of on-machine measurement of the surface normal during complex surface manufacturing, a highly robust normal vector extraction method using an Eddy current (EC) displacement sensor array is developed, the output of which is almost unaffected by surface brightness, machining coolant and environmental noise. A precise normal vector extraction model based on a triangular-distributed EC sensor array is first established. Calibration of the effects of object surface inclination and coupling interference on measurement results, and the relative position of EC sensors, is involved. A novel apparatus employing three EC sensors and a force transducer was designed, which can be easily integrated into the computer numerical control (CNC) machine tool spindle and/or robot terminal execution. Finally, to test the validity and practicability of the proposed method, typical experiments were conducted with specified testing pieces using the developed approach and system, such as an inclined plane and cylindrical and spherical surfaces.

  5. Good Teaching: The Goose Bump Response.

    ERIC Educational Resources Information Center

    Ricciotti, Joseph A.

    1988-01-01

    Teachers who can trigger the "goose bump" response have probably mastered the fine art of teaching. Such teachers are enthusiastic, excited about their subject matter, and genuinely care about their students. When "artistic" teachers manifest glaring teaching deficiencies, the sensitive principal overlooks these flaws or handles them without…

  6. Defect Inspection of Flip Chip Solder Bumps Using an Ultrasonic Transducer

    PubMed Central

    Su, Lei; Shi, Tielin; Xu, Zhensong; Lu, Xiangning; Liao, Guanglan

    2013-01-01

    Surface mount technology has spurred a rapid decrease in the size of electronic packages, where solder bump inspection of surface mount packages is crucial in the electronics manufacturing industry. In this study we demonstrate the feasibility of using a 230 MHz ultrasonic transducer for nondestructive flip chip testing. The reflected time domain signal was captured when the transducer scanning the flip chip, and the image of the flip chip was generated by scanning acoustic microscopy. Normalized cross-correlation was used to locate the center of solder bumps for segmenting the flip chip image. Then five features were extracted from the signals and images. The support vector machine was adopted to process the five features for classification and recognition. The results show the feasibility of this approach with high recognition rate, proving that defect inspection of flip chip solder bumps using the ultrasonic transducer has high potential in microelectronics packaging.

  7. THE ACS LCID PROJECT. IV. DETECTION OF THE RED GIANT BRANCH BUMP IN ISOLATED GALAXIES OF THE LOCAL GROUP

    SciTech Connect

    Monelli, M.; Hidalgo, S. L; Aparicio, A.; Gallart, C.; Cassisi, S.; Bernard, E. J.; Skillman, E. D. E-mail: carme@iac.e E-mail: shidalgo@iac.e E-mail: ejb@roe.ac.u

    2010-08-01

    We report the detection and analysis of the red giant branch (RGB) luminosity function bump in a sample of isolated dwarf galaxies in the Local Group. We have designed a new analysis approach comparing the observed color-magnitude diagrams (CMDs) with theoretical best-fit CMDs derived from precise estimates of the star formation histories of each galaxy. This analysis is based on studying the difference between the V magnitude of the RGB bump and the horizontal branch at the level of the RR Lyrae instability strip ({Delta}V {sup bump}{sub HB}) and we discuss here a technique for reliably measuring this quantity in complex stellar systems. By using this approach, we find that the difference between the observed and predicted values of {Delta}V {sup bump}{sub HB} is +0.13 {+-} 0.14 mag. This is smaller, by about a factor of 2, than the well-known discrepancy between theory and observation at low metallicity commonly derived for Galactic globular clusters (GCs). This result is confirmed by a comparison between the adopted theoretical framework and empirical estimates of the {Delta}V {sup bump}{sub HB} parameter for both a large database of Galactic GCs and for four other dwarf spheroidal galaxies for which this estimate is available in the literature. We also investigate the strength of the RGB bump feature (R{sub bump}), and find very good agreement between the observed and theoretically predicted R{sub bump} values. This agreement supports the reliability of the evolutionary lifetimes predicted by theoretical models of the evolution of low-mass stars.

  8. Structure of Three-Dimensional Separated Flow on Symmetric Bumps

    DTIC Science & Technology

    2005-11-30

    7300 and of thickness 6 over 2 circular based axisymmetric bumps of height H = 6 and 26 and one rectangular based symmetric bump of H = 26. LDV data...8217 v’) Re,, Reynolds number based on bump height, II / 1 , Reo, Momentum thickness Reynolds number. U,, 0 / m’ S Skewness, / (u )’ 1/S Reynolds stresses...analysis and the critical point saddle, node and focus theory which arc based on flow visualization ([Delery. 1992; Hunt et al.. 1978: Tobak and Peake

  9. A novel method for direct solder bump pull testing using lead-free solders

    NASA Astrophysics Data System (ADS)

    Turner, Gregory Alan

    This thesis focuses on the design, fabrication, and evaluation of a new method for testing the adhesion strength of lead-free solders, named the Isotraction Bump Pull method (IBP). In order to develop a direct solder joint-strength testing method that did not require customization for different solder types, bump sizes, specific equipment, or trial-and-error, a combination of two widely used and accepted standards was created. First, solder bumps were made from three types of lead free solder were generated on untreated copper PCB substrates using an in-house fabricated solder bump-on-demand generator, Following this, the newly developed method made use of a polymer epoxy to encapsulate the solder bumps that could then be tested under tension using a high precision universal vertical load machine. The tests produced repeatable and predictable results for each of the three alloys tested that were in agreement with the relative behavior of the same alloys using other testing methods in the literature. The median peak stress at failure for the three solders tested were 2020.52 psi, 940.57 psi, and 2781.0 psi, and were within one standard deviation of the of all data collected for each solder. The assumptions in this work that brittle fracture occurred through the Intermetallic Compound layer (IMC) were validated with the use of Energy-Dispersive X-Ray Spectrometry and high magnification of the fractured surface of both newly exposed sides of the test specimens. Following this, an examination of the process to apply the results from the tensile tests into standard material science equations for the fracture of the systems was performed..

  10. Cascading reminiscence bumps in popular music.

    PubMed

    Krumhansl, Carol Lynne; Zupnick, Justin Adam

    2013-10-01

    Autobiographical memories are disproportionately recalled for events in late adolescence and early adulthood, a phenomenon called the reminiscence bump. Previous studies on music have found autobiographical memories and life-long preferences for music from this period. In the present study, we probed young adults' personal memories associated with top hits over 5-and-a-half decades, as well as the context of their memories and their recognition of, preference for, quality judgments of, and emotional reactions to that music. All these measures showed the typical increase for music released during the two decades of their lives. Unexpectedly, we found that the same measures peaked for the music of participants' parents' generation. This finding points to the impact of music in childhood and suggests that these results reflect the prevalence of music in the home environment. An earlier peak occurred for 1960s music, which may be explained by its quality or by its transmission through two generations. We refer to this pattern of musical cultural transmission over generations as cascading reminiscence bumps.

  11. Two-Step Plasma Process for Cleaning Indium Bonding Bumps

    NASA Technical Reports Server (NTRS)

    Greer, Harold F.; Vasquez, Richard P.; Jones, Todd J.; Hoenk, Michael E.; Dickie, Matthew R.; Nikzad, Shouleh

    2009-01-01

    A two-step plasma process has been developed as a means of removing surface oxide layers from indium bumps used in flip-chip hybridization (bump bonding) of integrated circuits. The two-step plasma process makes it possible to remove surface indium oxide, without incurring the adverse effects of the acid etching process.

  12. Parametric study of pulsed thermal bumps in supersonic boundary layer

    NASA Astrophysics Data System (ADS)

    Yan, H.; Gaitonde, D.

    2011-09-01

    A three-dimensional numerical study is performed to explore the effect of pulsed spanwise-periodic surface thermal perturbation (also denoted as thermal bump) in a Mach 1.5 flat plate laminar boundary layer. A high-resolution upwind-biased Roe method is used with the compressive Van Leer harmonic limiter on a suitably refined mesh. The dependence of flow stability characteristics on the variation of thermal bump geometry (shape and dimension) and pulsing properties (disturbance amplitude and frequency) is assessed. It is shown that the finite-span thermal bumps generate streamwise vortices. When the thermal bump is pulsed, vortex shedding is observed, and the streamwise vorticity grows with the downstream distance. Analysis of the integrated disturbance energy indicates that the streamwise kinetic disturbance energy dominates over those associated with other two velocity and thermodynamic components. Immediately downstream of the bump, the dominant frequency corresponds to that of the imposed excitation while higher harmonic components are observed farther downstream. An analysis of parametric variation of bump shape and dimension indicates that finite bump span is important in injecting three dimensionality and that the rectangular shape results in faster disturbance growth than the circular one. The study also concludes that disturbance growth is non-linear with bump temperature and has a strong connection with pulsing frequency.

  13. The Physics of Bump Drafting in Car Racing

    ERIC Educational Resources Information Center

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-01-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

  14. Bump Bonding Using Metal-Coated Carbon Nanotubes

    NASA Technical Reports Server (NTRS)

    Lamb, James L.; Dickie, Matthew R.; Kowalczyk, Robert S.; Liao, Anna; Bronikowski, Michael J.

    2012-01-01

    Bump bonding hybridization techniques use arrays of indium bumps to electrically and mechanically join two chips together. Surface-tension issues limit bump sizes to roughly as wide as they are high. Pitches are limited to 50 microns with bumps only 8-14 microns high on each wafer. A new process uses oriented carbon nanotubes (CNTs) with a metal (indium) in a wicking process using capillary actions to increase the aspect ratio and pitch density of the connections for bump bonding hybridizations. It merges the properties of the CNTs and the metal bumps, providing enhanced material performance parameters. By merging the bumps with narrow and long CNTs oriented in the vertical direction, higher aspect ratios can be obtained if the metal can be made to wick. Possible aspect ratios increase from 1:1 to 20:1 for most applications, and to 100:1 for some applications. Possible pitch density increases of a factor of 10 are possible. Standard capillary theory would not normally allow indium or most other metals to be drawn into the oriented CNTs, because they are non-wetting. However, capillary action can be induced through the ability to fabricate oriented CNT bundles to desired spacings, and the use of deposition techniques and temperature to control the size and mobility of the liquid metal streams and associated reservoirs. This hybridization of two technologies (indium bumps and CNTs) may also provide for some additional benefits such as improved thermal management and possible current density increases.

  15. Bump in the blue axion isocurvature spectrum

    NASA Astrophysics Data System (ADS)

    Chung, Daniel J. H.; Upadhye, Amol

    2017-01-01

    Blue axion isocurvature perturbations are both theoretically well motivated and interesting from a detectability perspective. These power spectra generically have a break from the blue region to a flat region. Previous investigations of the power spectra were analytic, which left a gap in the predicted spectrum in the break region due to the nonapplicability of the used analytic techniques. We therefore compute the isocurvature spectrum numerically for an explicit supersymmetric axion model. We find a bump that enhances the isocurvature signal for this class of scenarios. A fitting function of three parameters is constructed that fits the spectrum well for the particular axion model we study. This fitting function should be useful for blue isocurvature signal hunting in data and making experimental sensitivity forecasts.

  16. Low-cost bump bonding activities at CERN

    NASA Astrophysics Data System (ADS)

    Vähänen, S.; Tick, T.; Campbell, M.

    2010-11-01

    Conventional bumping processes used in the fabrication of hybrid pixel detectors for High Energy Physics (HEP) experiments use electroplating for Under Bump Metallization (UBM) and solder bump deposition. This process is laborious, involves time consuming photolithography and can only be performed using whole wafers. Electroplating has been found to be expensive when used for the low volumes which are typical of HEP experiments. In the low-cost bump bonding development work, electroless deposition technology of UBM is studied as an alternative to the electroplating process in the bump size / pitch window beginning from 20 μm / 50 μm. Electroless UBM deposition used in combination with solder transfer techniques has the potential to significantly lower the cost of wafer bumping without requiring increased wafer volumes. A test vehicle design of sensor and readout chip, having daisy chains and Kelvin bump structures, was created to characterize the flip chip process with electroless UBM. Two batches of test vehicle wafers were manufactured with different bump pad metallization. Batch #1 had AlSi(1%) metallization, which is similar to the one used on sensor wafers, and Batch #2 had AlSi(2%)Cu(1%) metallization, which is very similar to the one used on readout wafers. Electroless UBMs were deposited on both wafer batches. In addition, electroplated Ni UBM and SnPb solder bumps were grown on the test sensor wafers. Test assemblies were made by flip chip bonding the solder-bumped test sensors against the test readout chips with electroless UBMs. Electrical yields and individual joint resistances were measured from assemblies, and the results were compared to a well known reference technique based on electroplated solder bumps structures on both chips. The electroless UBMs deposited on AlSi(2%)Cu(1%) metallization showed excellent electrical yields and small tolerances in individual joint resistance. The results from the UBMs deposited on AlSi(1%) metallization were non

  17. Stellar acoustics. I - Adiabatic pulse propagation and modal resonance in polytropic models of bump Cepheids

    NASA Astrophysics Data System (ADS)

    Whitney, C. A.

    1983-11-01

    An understanding of the Hertzsprung progression among bump Cepheids is sought in a dualistic viewpoint which combines the idea of propagating pulse echoes with that of modal resonance. Attention is focused on the spherically symmetric pulses that can be regenerated once per cycle if their round trip propagation time equals the period of the overall pulsation. The acoustic properties of polytropic models reveal that the conditions for such reinforcement are likely to be met in models for which the periods of the fundamental and the second overtone pulsation are in the ratio 2:1. Systematic departures from precise resonance may be responsible for the Hertzsprung progression.

  18. Precise Evaluation of Leaked Information with Secure Randomness Extraction in the Presence of Quantum Attacker

    NASA Astrophysics Data System (ADS)

    Hayashi, Masahito

    2015-01-01

    We treat secret key extraction when the eavesdropper has correlated quantum states. We propose quantum privacy amplification theorems different from Renner's, which are based on quantum conditional Rényi entropy of order 1 + s. Using those theorems, we derive an exponential rate of decrease for leaked information and the asymptotic equivocation rate, which have not been derived hitherto in the quantum setting.

  19. On the accuracy and precision of numerical waveforms: effect of waveform extraction methodology

    NASA Astrophysics Data System (ADS)

    Chu, Tony; Fong, Heather; Kumar, Prayush; Pfeiffer, Harald P.; Boyle, Michael; Hemberger, Daniel A.; Kidder, Lawrence E.; Scheel, Mark A.; Szilagyi, Bela

    2016-08-01

    We present a new set of 95 numerical relativity simulations of non-precessing binary black holes (BBHs). The simulations sample comprehensively both black-hole spins up to spin magnitude of 0.9, and cover mass ratios 1-3. The simulations cover on average 24 inspiral orbits, plus merger and ringdown, with low initial orbital eccentricities e\\lt {10}-4. A subset of the simulations extends the coverage of non-spinning BBHs up to mass ratio q = 10. Gravitational waveforms at asymptotic infinity are computed with two independent techniques: extrapolation and Cauchy characteristic extraction. An error analysis based on noise-weighted inner products is performed. We find that numerical truncation error, error due to gravitational wave extraction, and errors due to the Fourier transformation of signals with finite length of the numerical waveforms are of similar magnitude, with gravitational wave extraction errors dominating at noise-weighted mismatches of ˜ 3× {10}-4. This set of waveforms will serve to validate and improve aligned-spin waveform models for gravitational wave science.

  20. Towards Evidence-based Precision Medicine: Extracting Population Information from Biomedical Text using Binary Classifiers and Syntactic Patterns

    PubMed Central

    Raja, Kalpana; Dasot, Naman; Goyal, Pawan; Jonnalagadda, Siddhartha R

    2016-01-01

    Precision Medicine is an emerging approach for prevention and treatment of disease that considers individual variability in genes, environment, and lifestyle for each person. The dissemination of individualized evidence by automatically identifying population information in literature is a key for evidence-based precision medicine at the point-of-care. We propose a hybrid approach using natural language processing techniques to automatically extract the population information from biomedical literature. Our approach first implements a binary classifier to classify sentences with or without population information. A rule-based system based on syntactic-tree regular expressions is then applied to sentences containing population information to extract the population named entities. The proposed two-stage approach achieved an F-score of 0.81 using a MaxEnt classifier and the rule- based system, and an F-score of 0.87 using a Nai've-Bayes classifier and the rule-based system, and performed relatively well compared to many existing systems. The system and evaluation dataset is being released as open source. PMID:27570671

  1. Extracting Accurate and Precise Topography from Lroc Narrow Angle Camera Stereo Observations

    NASA Astrophysics Data System (ADS)

    Henriksen, M. R.; Manheim, M. R.; Speyerer, E. J.; Robinson, M. S.; LROC Team

    2016-06-01

    The Lunar Reconnaissance Orbiter Camera (LROC) includes two identical Narrow Angle Cameras (NAC) that acquire meter scale imaging. Stereo observations are acquired by imaging from two or more orbits, including at least one off-nadir slew. Digital terrain models (DTMs) generated from the stereo observations are controlled to Lunar Orbiter Laser Altimeter (LOLA) elevation profiles. With current processing methods, digital terrain models (DTM) have absolute accuracies commensurate than the uncertainties of the LOLA profiles (~10 m horizontally and ~1 m vertically) and relative horizontal and vertical precisions better than the pixel scale of the DTMs (2 to 5 m). The NAC stereo pairs and derived DTMs represent an invaluable tool for science and exploration purposes. We computed slope statistics from 81 highland and 31 mare DTMs across a range of baselines. Overlapping DTMs of single stereo sets were also combined to form larger area DTM mosaics, enabling detailed characterization of large geomorphic features and providing a key resource for future exploration planning. Currently, two percent of the lunar surface is imaged in NAC stereo and continued acquisition of stereo observations will serve to strengthen our knowledge of the Moon and geologic processes that occur on all the terrestrial planets.

  2. AstroImageJ: Image Processing and Photometric Extraction for Ultra-precise Astronomical Light Curves

    NASA Astrophysics Data System (ADS)

    Collins, Karen A.; Kielkopf, John F.; Stassun, Keivan G.; Hessman, Frederic V.

    2017-02-01

    ImageJ is a graphical user interface (GUI) driven, public domain, Java-based, software package for general image processing traditionally used mainly in life sciences fields. The image processing capabilities of ImageJ are useful and extendable to other scientific fields. Here we present AstroImageJ (AIJ), which provides an astronomy specific image display environment and tools for astronomy specific image calibration and data reduction. Although AIJ maintains the general purpose image processing capabilities of ImageJ, AIJ is streamlined for time-series differential photometry, light curve detrending and fitting, and light curve plotting, especially for applications requiring ultra-precise light curves (e.g., exoplanet transits). AIJ reads and writes standard Flexible Image Transport System (FITS) files, as well as other common image formats, provides FITS header viewing and editing, and is World Coordinate System aware, including an automated interface to the astrometry.net web portal for plate solving images. AIJ provides research grade image calibration and analysis tools with a GUI driven approach, and easily installed cross-platform compatibility. It enables new users, even at the level of undergraduate student, high school student, or amateur astronomer, to quickly start processing, modeling, and plotting astronomical image data with one tightly integrated software package.

  3. Extracting accurate and precise topography from LROC narrow angle camera stereo observations

    NASA Astrophysics Data System (ADS)

    Henriksen, M. R.; Manheim, M. R.; Burns, K. N.; Seymour, P.; Speyerer, E. J.; Deran, A.; Boyd, A. K.; Howington-Kraus, E.; Rosiek, M. R.; Archinal, B. A.; Robinson, M. S.

    2017-02-01

    The Lunar Reconnaissance Orbiter Camera (LROC) includes two identical Narrow Angle Cameras (NAC) that each provide 0.5 to 2.0 m scale images of the lunar surface. Although not designed as a stereo system, LROC can acquire NAC stereo observations over two or more orbits using at least one off-nadir slew. Digital terrain models (DTMs) are generated from sets of stereo images and registered to profiles from the Lunar Orbiter Laser Altimeter (LOLA) to improve absolute accuracy. With current processing methods, DTMs have absolute accuracies better than the uncertainties of the LOLA profiles and relative vertical and horizontal precisions less than the pixel scale of the DTMs (2-5 m). We computed slope statistics from 81 highland and 31 mare DTMs across a range of baselines. For a baseline of 15 m the highland mean slope parameters are: median = 9.1°, mean = 11.0°, standard deviation = 7.0°. For the mare the mean slope parameters are: median = 3.5°, mean = 4.9°, standard deviation = 4.5°. The slope values for the highland terrain are steeper than previously reported, likely due to a bias in targeting of the NAC DTMs toward higher relief features in the highland terrain. Overlapping DTMs of single stereo sets were also combined to form larger area DTM mosaics that enable detailed characterization of large geomorphic features. From one DTM mosaic we mapped a large viscous flow related to the Orientale basin ejecta and estimated its thickness and volume to exceed 300 m and 500 km3, respectively. Despite its ∼3.8 billion year age the flow still exhibits unconfined margin slopes above 30°, in some cases exceeding the angle of repose, consistent with deposition of material rich in impact melt. We show that the NAC stereo pairs and derived DTMs represent an invaluable tool for science and exploration purposes. At this date about 2% of the lunar surface is imaged in high-resolution stereo, and continued acquisition of stereo observations will serve to strengthen our

  4. New pulsed orbit bump magnets for the Fermilab Booster Synchrotron

    SciTech Connect

    Lackey, J.R.; Carson, J.A.; Ginsburg, C.M.; Glass, H.D.; Harding, D.J.; Kashikhin, V.S.; Makarov, A.; Prebys, E.J.; /Fermilab

    2005-05-01

    The beam from the Fermilab Linac is injected onto a bump in the closed orbit of the Booster Synchrotron where a carbon foil strips the electrons from the Linac's negative ion hydrogen beam. Although the Booster itself runs at 15 Hz, heat dissipation in the orbit bump magnets has been one limitation to the fraction of the cycles that can be used for beam. New 0.28 T pulsed dipole magnets have been constructed that will fit into the same space as the old ones, run at the full repetition rate of the Booster, and provide a larger bump to allow a cleaner injection orbit. The new magnets use a ferrite in the yoke rather than laminated steel.

  5. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    SciTech Connect

    Adams, T.; Batra, P.; Bugel, Leonard G.; Camilleri, Leslie Loris; Conrad, Janet Marie; de Gouvea, A.; Fisher, Peter H.; Formaggio, Joseph Angelo; Jenkins, J.; Karagiorgi, Georgia S.; Kobilarcik, T.R.; /Fermilab /Texas U.

    2009-06-01

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDFs). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parameterized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of 'Beyond the Standard Model' physics.

  6. Full waveform inversion with an auxiliary bump functional

    NASA Astrophysics Data System (ADS)

    Bharadwaj, Pawan; Mulder, Wim; Drijkoningen, Guy

    2016-08-01

    Least-squares inversion of seismic arrivals can provide remarkably detailed models of the Earth's subsurface. However, cycle skipping associated with these oscillatory arrivals is the main cause for local minima in the least-squares objective function. Therefore, it is often difficult for descent methods to converge to the solution without an accurate initial large-scale velocity estimate. The low frequencies in the arrivals, needed to update the large-scale components in the velocity model, are usually unreliable or absent. To overcome this difficulty, we propose a multi-objective inversion scheme that uses the conventional least-squares functional along with an auxiliary data-domain objective. As the auxiliary objective effectively replaces the seismic arrivals by bumps, we call it the bump functional. The bump functional minimization can be made far less sensitive to cycle skipping and can deal with multiple arrivals in the data. However, it can only be used as an auxiliary objective since it usually does not provide a unique model after minimization even when the regularized-least-squares functional has a unique global minimum and hence a unique solution. The role of the bump functional during the multi-objective inversion is to guide the optimization towards the global minimum by pulling the trapped solution out of the local minima associated with the least-squares functional whenever necessary. The computational complexity of the bump functional is equivalent to that of the least-squares functional. In this paper, we describe various characteristics of the bump functional using simple and illustrative numerical examples. We also demonstrate the effectiveness of the proposed multi-objective inversion scheme by considering more realistic examples. These include synthetic and field data from a cross-well experiment, surface-seismic synthetic data with reflections and synthetic data with refracted arrivals at long offsets.

  7. Growth Characteristics Downstream of a Shallow Bump: Computation and Experiment

    NASA Technical Reports Server (NTRS)

    Joslin, Ronald D.; Grosch, Chester E.

    1996-01-01

    Measurements of the velocity field created by a shallow bump on a wall revealed that an energy peak in the spanwise spectrum associated with the driver decays and an initially small-amplitude secondary mode rapidly grows with distance downstream of the bump. Linear theories could not provide an explanation for this growing mode. The present Navier-Stokes simulation replicates and confirms the experimental results. Insight into the structure of the flow was obtained from a study of the results of the calculations and is presented.

  8. The Influence of Road Bumps Characteristics on the Chaotic Vibration of a Nonlinear Full-Vehicle Model with Driver

    NASA Astrophysics Data System (ADS)

    Fakhraei, J.; Khanlo, H. M.; Ghayour, M.; Faramarzi, Kh.

    In this paper, the chaotic behavior of a ground vehicle system with driver subjected to road disturbances is studied and the relationship between the nonlinear vibration of the vehicle and ride comfort is evaluated. The vehicle system is modeled as fully nonlinear with seven degrees of freedom and an additional degree of freedom for driver (8-DOF). The excitation force is the road irregularities that are assumed as road speed control bumps. The sinusoidal, consecutive half-sine and dented-rectangular waveforms are considered to simulate the road speed control bumps. The nonlinearities of the system are due to the nonlinear springs and dampers that are used in the suspension system and tires. The governing differential equations are extracted under Newton-Euler laws and solved via numerical methods. The chaotic behaviors were studied in more detail with special techniques such as bifurcation diagrams, phase plane portrait, Poincaré map and Lyapunov exponents. The ride comfort was evaluated as the RMS value of the vertical displacement of the vehicle body and driver. Firstly, the effect of amplitude (height) and frequency (vehicle’s speed) of these speed control bumps on chaotic vibrations of vehicle are studied. The obtained results show that various forms of vibrations, such as periodic, subharmonic and chaotic vibrations, can be detected in the system behavior with the change of the height and frequency of speed control bumps and present different types of strange attractors in the vehicle with and without driver. Then, the influence of nonlinear vibration on ride comfort and the relationship between chaotic vibrations of the vehicle and driving comfort are investigated. The results of analyzing the RMS diagrams reveal that the chaotic behaviors can directly affect the driving comfort and lead to the driver’s comfort being reduced. The obtained results can be used in the design of vehicle and road bumps pavement.

  9. Actinic characterization of EUV bump-type phase defects

    SciTech Connect

    Goldberg, Kenneth A.; Mochi, Iacopo; Liang, Ted

    2011-01-10

    Despite tremendous progress and learning with EUV lithography, quantitative experimental information about the severity of point-like phase defects remains in short supply. We present a study of measured, EUV aerial images from a series of well-characterized, open-field, bump-type programmed phase defects, created on a substrate before multilayer deposition.

  10. Numerical characterization of bump formation in the runaway electron tail

    NASA Astrophysics Data System (ADS)

    Decker, J.; Hirvijoki, E.; Embreus, O.; Peysson, Y.; Stahl, A.; Pusztai, I.; Fülöp, T.

    2016-02-01

    Runaway electrons are generated in a magnetized plasma when the parallel electric field exceeds a critical value. For such electrons with energies typically reaching tens of MeV, the Abraham-Lorentz-Dirac (ALD) radiation force, in reaction to the synchrotron emission, is significant and can be the dominant process limiting electron acceleration. The effect of the ALD force on runaway electron dynamics in a homogeneous plasma is investigated using the relativistic finite-difference Fokker-Planck codes LUKE (Decker and Peysson 2004 Report EUR-CEA-FC-1736, Euratom-CEA), and CODE (Landreman et al 2014 Comput. Phys. Commun. 185 847). The time evolution of the distribution function is analyzed as a function of the relevant parameters: parallel electric field, background magnetic field, and effective charge. Under the action of the ALD force, we find that runaway electrons are subject to an energy limit, and that the electron distribution evolves towards a steady-state. In addition, a bump is formed in the tail of the electron distribution function if the electric field is sufficiently strong. The mechanisms leading to the bump formation and energy limit involve both the parallel and perpendicular momentum dynamics; they are described in detail. An estimate for the bump location in momentum space is derived. We observe that the energy of runaway electrons in the bump increases with the electric field amplitude, while the population increases with the bulk electron temperature. The presence of the bump divides the electron distribution into a runaway beam and a bulk population. This mechanism may give rise to beam-plasma types of instabilities that could, in turn, pump energy from runaway electrons and alter their confinement.

  11. Reliability Investigations on SnAg Bumps on Substrate Pads with Different Pad Finish

    SciTech Connect

    Bauer, R.; Ebersberger, B.; Kupfer, C.; Alexa, L.

    2006-02-07

    SnAg solder bump is one bump type which is used to replace eutectic SnPb bumps. In this work tests have been done to characterize the reliability properties of this bump type. Electromigration (EM) tests, which were accelerated by high current and high temperature and high temperature storage (HTS) tests were performed. It was found that the reliability properties are sensitive to the material combinations in the interconnect stack. The interconnect stack includes substrate pad, pad finish, bump, underbump metallization (UBM) and the chip pad. Therefore separate test groups for SnAg bumps on Cu substrate pads with organic solderability preservative (OSP) finish and the identical bumps on pads with Ni/Au finish were used. In this paper the reliability test results and the corresponding failure analysis are presented. Some explanations about the differences in formation of intermetallic compounds (IMCs) are given.

  12. Bump formation in a binary attractor neural network

    SciTech Connect

    Koroutchev, Kostadin; Korutcheva, Elka

    2006-02-15

    The conditions for the formation of local bumps in the activity of binary attractor neural networks with spatially dependent connectivity are investigated. We show that these formations are observed when asymmetry between the activity during the retrieval and learning is imposed. An analytical approximation for the order parameters is derived. The corresponding phase diagram shows a relatively large and stable region where this effect is observed, although critical storage and information capacities drastically decrease inside that region. We demonstrate that the stability of the network, when starting from the bump formation, is larger than the stability when starting even from the whole pattern. Finally, we show a very good agreement between the analytical results and the simulations performed for different topologies of the network.

  13. [Application of bump texture mapping in block mapping].

    PubMed

    Zhang, Jie; Cheng, Bin; Wang, Xiaoming; Zhou, Jingtao

    2014-08-01

    With the progresses of the research on "Digital Human", more and more information has been needed for the setting up of the three-dimensional digital models of human organs. In the present paper, based on the method of block mapping with a normal-style bump mapping method, we normalized the vector of the surface of the models, computed offset of the texture coordinates and added to them. The projection of the coordinates to the tangential space complemented the disturbance to the vector of models' surface. The method was proposed with bump texture mapping on the surface of the biological models of organs to improve the impression of the visualization of the organ models and to enhance the sense of reality of the models.

  14. Characterization of indium and solder bump bonding for pixel detectors

    SciTech Connect

    Selcuk Cihangir and Simon Kwan

    2000-09-28

    A review of different bump-bonding processes used for pixel detectors is given. A large scale test on daisy-chained components from two vendors has been carried out at Fermilab to characterize the yield of these processes. The vendors are Advanced Interconnect Technology Ltd. (AIT) of Hong Kong and MCNC in North Carolina, US. The results from this test are presented and technical challenges encountered are discussed.

  15. Electromigration of composite Sn-Ag-Cu solder bumps

    NASA Astrophysics Data System (ADS)

    Sharma, Ashutosh; Xu, Di Erick; Chow, Jasper; Mayer, Michael; Sohn, Heung-Rak; Jung, Jae Pil

    2015-11-01

    This study investigates the electromigration (EM) behavior of lead free Sn-Ag-Cu (SAC) solder alloys that were reinforced with different types of nanoparticles [Copper-coated carbon nanotubes (Cu/CNT), La2O3, Graphene, SiC, and ZrO2]. The composite solders were bumped on a Cu substrate at 220°C, and the resistance of the bumped solders was measured using a four wire setup. Current aging was carried out for 4 hours at a temperature of 160°C, and an increase in resistance was noted during this time. Of all the composite solders that were studied, La2O3 and SiC reinforced SAC solders exhibited the smallest resistances after current aging. However, the rate of change in the resistance at room temperature was lower for the SiC-reinforced SAC solder. The SAC and Graphene reinforced SAC solder bumps completely failed within 15 - 20 min of these tests. The SiC nanoparticles were reported to possibly entrap the SAC atoms better than other nanoparticles with a lower rate of EM. [Figure not available: see fulltext.

  16. The reminiscence bump in autobiographical memory and for public events: A comparison across different cueing methods.

    PubMed

    Koppel, Jonathan; Berntsen, Dorthe

    2016-01-01

    The reminiscence bump has been found for both autobiographical memories and memories of public events. However, there have been few comparisons of the bump across each type of event. In the current study, therefore, we compared the bump for autobiographical memories versus the bump for memories of public events. We did so between-subjects, through two cueing methods administered within-subjects, the cue word method and the important memories method. For word-cued memories, we found a similar bump from ages 5 to 19 for both types of memories. However, the bump was more pronounced for autobiographical memories. For most important memories, we found a bump from ages 20 to 29 in autobiographical memory, but little discernible age pattern for public events. Rather, specific public events (e.g., the Fall of the Berlin Wall) dominated recall, producing a chronological distribution characterised by spikes in citations according to the years these events occurred. Follow-up analyses suggested that the bump in most important autobiographical memories was a function of the cultural life script. Our findings did not yield support for any of the dominant existing accounts of the bump as underlying the bump in word-cued memories.

  17. A study of thermal cycling and radiation effects on indium and solder bump bonding

    SciTech Connect

    Selcuk Cihangir et al.

    2001-09-12

    The BTeV hybrid pixel detector is constructed of readout chips and sensor arrays which are developed separately. The detector is assembled by flip-chip mating of the two parts. This method requires the availability of highly reliable, reasonably low cost fine-pitch flip-chip attachment technology. We have tested the quality of two bump-bonding technologies; indium bumps (by Advanced Interconnect Technology Ltd. (AIT) of Hong Kong) and fluxless solder bumps (by MCNC in North Carolina, USA). The results have been presented elsewhere[1]. In this paper we describe tests we performed to further evaluate these technologies. We subjected 15 indium bump-bonded and 15 fluxless solder bump-bonded dummy detectors through a thermal cycle and then a dose of radiation to observe the effects of cooling, heating and radiation on bump-bonds.

  18. Aqueous-based thick photoresist removal for bumping applications

    NASA Astrophysics Data System (ADS)

    Moore, John C.; Brewer, Alex J.; Law, Alman; Pettit, Jared M.

    2015-03-01

    Cleaning processes account for over 25% of processing in microelectronic manufacturing [1], suggesting electronics to be one of the most chemical intensive markets in commerce. Industry roadmaps exist to reduce chemical exposure, usage, and waste [2]. Companies are encouraged to create a safer working environment, or green factory, and ultimately become certified similar to LEED in the building industry [3]. A significant step in this direction is the integration of aqueous-based photoresist (PR) strippers which eliminate regulatory risks and cut costs by over 50%. One of the largest organic solvent usages is based upon thick PR removal during bumping processes [4-6]. Using market projections and the benefits of recycling, it is estimated that over 1,000 metric tons (mt) of residuals originating from bumping processes are incinerated or sent to a landfill. Aqueous-based stripping would eliminate this disposal while also reducing the daily risks to workers and added permitting costs. Positive-tone PR dissolves in aqueous strippers while negative-tone systems are lifted-off from the substrate, bumps, pillars, and redistribution layers (RDL). While the wafers are further processed and rinsed, the lifted-off PR is pumped from the tank, collected onto a filter, and periodically back-flushed to the trash. The PR solids become a non-hazardous plastic waste while the liquids are mixed with the developer stream, neutralized, filtered, and in most cases, disposed to the sewer. Regardless of PR thickness, removal processes may be tuned to perform in <15min, performing at rates nearly 10X faster than solvents with higher bath lives. A balanced formula is safe for metals, dielectrics, and may be customized to any fab.

  19. The role of UV bump in line emission

    NASA Astrophysics Data System (ADS)

    Zheng, Wei; Luc, Binette; Fang, Li-Zhi

    1992-05-01

    It is suggested that the UV bump which the low-ionization lines of the Seyfert galaxy Fairall 9 follow has a shape more complicated than a simple blackbody curve and has a rather steep drop around 30 eV. The degree of luminosity dependence of the equivalent width of Ly-alpha, semiforbidden Si IV, and C IV is inversely correlated with an individual emission line's ionization level. This explains why only the C IV equivalent width exhibits a significant luminosity dependence (the Baldwin effect).

  20. Analysis of Power Generating Speed Bumps Made of Concrete Foam Composite

    NASA Astrophysics Data System (ADS)

    Syam, B.; Muttaqin, M.; Hastrino, D.; Sebayang, A.; Basuki, W. S.; Sabri, M.; Abda, S.

    2017-03-01

    This paper discusses the analysis of speed bump made of concrete foam composite which is used to generate electrical power. Speed bumps are designed to decelerate the speed of vehicles before passing through toll gates, public areas, or any other safety purposes. In Indonesia a speed bump should be designed in the accordance with KM Menhub 3 year 1994. In this research, the speed bump was manufactured with dimensions and geometry comply to the regulation mentioned above. Concrete foam composite speed bumps were used due to its light weight and relatively strong to receive vertical forces from the tyres of vehicles passing over the bumps. The reinforcement materials are processed from empty fruit bunch of oil palm. The materials were subjected to various tests to obtain its physical and mechanical properties. To analyze the structure stability of the speed bumps some models were analyzed using a FEM-based numerical softwares. It was obtained that the speed bumps coupled with polymeric composite bar (3 inches in diameter) are significantly reduce the radial stresses. In addition, the speed bumps equipped with polymeric composite casing or steel casing are also suitable for use as part of system components in producing electrical energy.

  1. Effectiveness of Emittance Bumps in the NLC and US Cold LC Main Linear Accelerators (LCC-0138)

    SciTech Connect

    Tenenbaum, P

    2004-05-13

    We report on a series of studies on the effectiveness of closed orbit bumps in the linacs of the NLC and the USColdLC. In the first study, emittance dilutions of a pure-wakefield or pure-dispersion character are introduced in each linac, and a set of emittance bumps is tested to determine the most effective bump location in the linac, and the net effectiveness. In the second study, a more realistic set of dilutions are introduced and the wakefield bumps used in the first study are applied.

  2. Electronic simulation of the supported liquid membrane in electromembrane extraction systems: Improvement of the extraction by precise periodical reversing of the field polarity.

    PubMed

    Moazami, Hamid Reza; Nojavan, Saeed; Zahedi, Pegah; Davarani, Saied Saeed Hosseiny

    2014-09-02

    In order to understand the limitations of electromebrane extraction procedure better, a simple equivalent circuit has been proposed for a supported liquid membrane consisting of a resistor and a low leakage capacitor in series. To verify the equivalent circuit, it was subjected to a simulated periodical polarity changing potential and the resulting time variation of the current was compared with that of a real electromembrane extraction system. The results showed a good agreement between the simulated current patterns and those of the real ones. In order to investigate the impact of various limiting factors, the corresponding values of the equivalent circuit were estimated for a real electromembrane extraction system and were attributed to the physical parameters of the extraction system. A dual charge transfer mechanism was proposed for electromembrane extraction by combining general migration equation and fundamental aspects derived from the simulation. Dual mechanism comprises a current dependent contribution of analyte in total current and could support the possibility of an improvement in performance of an electromembrane extraction by application of an asymmetric polarity changing potential. The optimization of frequency and duty cycle of the asymmetric polarity exchanging potential resulted in a higher recovery (2.17 times greater) in comparison with the conventional electromebrane extraction. The simulation also provided more quantitative approaches toward the investigation of the mechanism of extraction and contribution of different limiting factors in electromembrane extraction. Results showed that the buildup of the double layer is the main limiting factor and the Joule heating has lesser impact on the performance of an electromebrane extraction system.

  3. Sensory feedback in a bump attractor model of path integration.

    PubMed

    Poll, Daniel B; Nguyen, Khanh; Kilpatrick, Zachary P

    2016-04-01

    Mammalian spatial navigation systems utilize several different sensory information channels. This information is converted into a neural code that represents the animal's current position in space by engaging place cell, grid cell, and head direction cell networks. In particular, sensory landmark (allothetic) cues can be utilized in concert with an animal's knowledge of its own velocity (idiothetic) cues to generate a more accurate representation of position than path integration provides on its own (Battaglia et al. The Journal of Neuroscience 24(19):4541-4550 (2004)). We develop a computational model that merges path integration with feedback from external sensory cues that provide a reliable representation of spatial position along an annular track. Starting with a continuous bump attractor model, we explore the impact of synaptic spatial asymmetry and heterogeneity, which disrupt the position code of the path integration process. We use asymptotic analysis to reduce the bump attractor model to a single scalar equation whose potential represents the impact of asymmetry and heterogeneity. Such imperfections cause errors to build up when the network performs path integration, but these errors can be corrected by an external control signal representing the effects of sensory cues. We demonstrate that there is an optimal strength and decay rate of the control signal when cues appear either periodically or randomly. A similar analysis is performed when errors in path integration arise from dynamic noise fluctuations. Again, there is an optimal strength and decay of discrete control that minimizes the path integration error.

  4. Experimental and modeling study of the flow over a skewed bump

    NASA Astrophysics Data System (ADS)

    Ching, David S.; Elkins, Christopher J.; Eaton, John K.

    2016-11-01

    Three-dimensional separated flows can be very sensitive to geometry and inlet conditions, such that a small change in the geometry or the upstream boundary layer could cause the flow structure to change drastically. This study examines the geometric sensitivity of a skewed bump with axis ratio 4/3 by changing the angle of the bump with respect to the flow. The three-dimensional, three-component mean velocity field was acquired using Magnetic Resonance Velocimetry (MRV) for several bump angles. The flow is dominated by large coherent vortices in the wake. For a symmetric case, two counter-rotating vortices exist in the wake, but when the bump is skewed relative to the oncoming flow one vortex structure is much stronger and overwhelms the other vortex. A comparison to RANS simulations found that the RANS simulations predict the velocity fields with reasonable accuracy within the separation bubble, but are very inaccurate downstream of reattachment. Using a time-resolved MRV sequence, the shedding frequency of the wake was determined for two bump angles. Hot-wire anemometry confirmed the shedding frequencies found from the MRV data and observed that the shedding frequency is sensitive to the bump angle at low bump angles, but is insensitive at high bump angles. Funding provided by the Office of Naval Research.

  5. Study of indium and solder bumps for the BTeV Pixel Detector

    SciTech Connect

    Simon W Kwan et al.

    2003-11-05

    The pixel detector proposed for the BTeV experiment at the Fermilab Tevatron will use bump-bonding technology based on either Indium or Pb/Sn solder to connect the front-end readout chips to the silicon pixel sensors. We have studied the strength of the bumps by visual inspection of the bumps bonding silicon sensor modules to dummy chips made out of glass. The studies were done before and after thermal cycles, exposed to intense irradiation, and with the assemblies glued to a graphite substrate. We have also carried out studies on effects of temperature changes on both types of bump bonds by observing the responses of single-chip pixel detectors to an Sr{sup 90} source. We report the results from these studies and our plan to measure the effect of cryogenic temperatures on the bumps.

  6. Waves, bumps, and patterns in neural field theories.

    PubMed

    Coombes, S

    2005-08-01

    Neural field models of firing rate activity have had a major impact in helping to develop an understanding of the dynamics seen in brain slice preparations. These models typically take the form of integro-differential equations. Their non-local nature has led to the development of a set of analytical and numerical tools for the study of waves, bumps and patterns, based around natural extensions of those used for local differential equation models. In this paper we present a review of such techniques and show how recent advances have opened the way for future studies of neural fields in both one and two dimensions that can incorporate realistic forms of axo-dendritic interactions and the slow intrinsic currents that underlie bursting behaviour in single neurons.

  7. Bumps, witches and bouncing beams: lab investigations of internal waves

    NASA Astrophysics Data System (ADS)

    Peacock, Thomas; Balmforth, Neil; Tabaei, Ali

    2005-11-01

    There is a great, ongoing effort to better understand the processes surrounding internal wave generation, propagation and dissipation in the oceans. To contribute to this effort, we are in the process of establishing a state-of-the-art experimental facility. The facility, based around the digital schlieren method, is designed to investigate both linear and non-linear phenomena in a laboratory setting. We here report the latest experimental results concerning tidal conversion by typical topographic features, such as a Gaussian bump and a knife-edge. The quantitative results compare very well with theoretical predictions developed from the classic work of Bell and Hurley, and more recent analysis of subcritical topography by Balmforth et al. In addition, we present more details on recently published results concerning the nonlinear generation of second-harmonic wavebeams at reflecting boundaries.

  8. A gas chromatography/pyrolysis/isotope ratio mass spectrometry system for high-precision deltaD measurements of atmospheric methane extracted from ice cores.

    PubMed

    Bock, Michael; Schmitt, Jochen; Behrens, Melanie; Möller, Lars; Schneider, Robert; Sapart, Celia; Fischer, Hubertus

    2010-03-15

    Air enclosures in polar ice cores represent the only direct paleoatmospheric archive. Analysis of the entrapped air provides clues to the climate system of the past in decadal to centennial resolution. A wealth of information has been gained from measurements of concentrations of greenhouse gases; however, little is known about their isotopic composition. In particular, stable isotopologues (deltaD and delta(13)C) of methane (CH(4)) record valuable information on its global cycle as the different sources exhibit distinct carbon and hydrogen isotopic composition. However, CH(4) isotope analysis is limited by the large sample size required and the demanding analysis as high precision is required. Here we present a highly automated, high-precision online gas chromatography/pyrolysis/isotope ratio monitoring mass spectrometry (GC/P/irmMS) technique for the analysis of deltaD(CH(4)). It includes gas extraction from ice, preconcentration, gas chromatographic separation and pyrolysis of CH(4) from roughly 500 g of ice with CH(4) concentrations as low as 350 ppbv. Ice samples with approximately 40 mL air and only approximately 1 nmol CH(4) can be measured with a precision of 3.4 per thousand. The precision for 65 mL air samples with recent atmospheric concentration is 1.5 per thousand. The CH(4) concentration can be obtained along with isotope data which is crucial for reporting ice core data on matched time scales and enables us to detect flaws in the measurement procedure. Custom-made script-based processing of MS raw and peak data enhance the system's performance with respect to stability, peak size dependency, hence precision and accuracy and last but not least time requirement.

  9. A precise extraction of the induced polarization in the 4He(e,e'p)3H reaction

    SciTech Connect

    S.P. Malace, M. Paolone, S. Strauch

    2011-01-01

    We measured with unprecedented precision the induced polarization Py in 4He(e,e'p)3H at Q^2 = 0.8 (GeV/c)^2 and 1.3 (GeV/c)^2. The induced polarization is indicative of reaction-mechanism effects beyond the impulse approximation. Our results are in agreement with a relativistic distorted-wave impulse approximation calculation but are over-estimated by a calculation with strong charge-exchange effects. Our data are used to constrain the strength of the spin independent charge-exchange term in the latter calculation.

  10. A study of thermal cycling and radiation effects on indium and solder bump bonds

    SciTech Connect

    Simon Kwan et al.

    2001-12-11

    The BTeV hybrid pixel detector is constructed of readout chips and sensor arrays which are developed separately. The detector is assembled by flip-chip mating of the two parts. This method requires the availability of highly reliable, reasonably low cost fine-pitch flip-chip attachment technology. We have tested the quality of two bump-bonding technologies; indium bumps (by Advanced Interconnect Technology Ltd. (AIT) of Hong Kong) and fluxless solder bumps (by MCNC in North Carolina, USA). The results have been presented elsewhere [1]. In this paper we describe tests we performed to further evaluate these technologies. We subjected 15 indium bump-bonded and 15 fluxless solder bump-bonded dummy detectors through a thermal cycle and then a dose of radiation to observe the effects of cooling, heating and radiation on bump-bonds. We also exercised the processes of HDI mounting and wire bonding to some of the dummy detectors to see the effect of these processes on bump bonds.

  11. Low-cost bump-bonding processes for high energy physics pixel detectors

    NASA Astrophysics Data System (ADS)

    Caselle, M.; Blank, T.; Colombo, F.; Dierlamm, A.; Husemann, U.; Kudella, S.; Weber, M.

    2016-01-01

    In the next generation of collider experiments detectors will be challenged by unprecedented particle fluxes. Thus large detector arrays of highly pixelated detectors with minimal dead area will be required at reasonable costs. Bump-bonding of pixel detectors has been shown to be a major cost-driver. KIT is one of five production centers of the CMS barrel pixel detector for the Phase I Upgrade. In this contribution the SnPb bump-bonding process and the production yield is reported. In parallel to the production of the new CMS pixel detector, several alternatives to the expensive photolithography electroplating/electroless metal deposition technologies are developing. Recent progress and challenges faced in the development of bump-bonding technology based on gold-stud bonding by thin (15 μm) gold wire is presented. This technique allows producing metal bumps with diameters down to 30 μm without using photolithography processes, which are typically required to provide suitable under bump metallization. The short setup time for the bumping process makes gold-stud bump-bonding highly attractive (and affordable) for the flip-chipping of single prototype ICs, which is the main limitation of the current photolithography processes.

  12. Precision measurement of the ratio B(t→Wb)/B(t→Wq) and extraction of V(tb).

    PubMed

    Abazov, V M; Abbott, B; Acharya, B S; Adams, M; Adams, T; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Aoki, M; Arov, M; Askew, A; Åsman, B; Atramentov, O; Avila, C; BackusMayes, J; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, S; Barberis, E; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bazterra, V; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Blazey, G; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brandt, O; Brock, R; Brooijmans, G; Bross, A; Brown, D; Brown, J; Bu, X B; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Calpas, B; Camacho-Pérez, E; Carrasco-Lizarraga, M A; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Chen, G; Chevalier-Théry, S; Cho, D K; Cho, S W; Choi, S; Choudhary, B; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Croc, A; Cutts, D; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Deterre, C; DeVaughan, K; Diehl, H T; Diesburg, M; Ding, P F; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duggan, D; Duperrin, A; Dutt, S; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Evans, H; Evdokimov, A; Evdokimov, V N; Facini, G; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fuess, S; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geng, W; Gerbaudo, D; Gerber, C E; Gershtein, Y; Ginther, G; Golovanov, G; Goussiou, A; Grannis, P D; Greder, S; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guillemin, T; Guo, F; Gutierrez, G; Gutierrez, P; Haas, A; Hagopian, S; Haley, J; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Head, T; Hebbeker, T; Hedin, D; Hegab, H; Heinson, A P; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hoang, T; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hubacek, Z; Huske, N; Hynek, V; Iashvili, I; Ilchenko, Y; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jamin, D; Jayasinghe, A; Jesik, R; Johns, K; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Joshi, J; Jung, A W; Juste, A; Kaadze, K; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y N; Kirby, M H; Kohli, J M; Kozelov, A V; Kraus, J; Kulikov, S; Kumar, A; Kupco, A; Kurča, T; Kuzmin, V A; Kvita, J; Lammers, S; Landsberg, G; Lebrun, P; Lee, H S; Lee, S W; Lee, W M; Lellouch, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Lopes de Sa, R; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Madar, R; Magaña-Villalba, R; Malik, S; Malyshev, V L; Maravin, Y; Martínez-Ortega, J; McCarthy, R; McGivern, C L; Meijer, M M; Melnitchouk, A; Menezes, D; Mercadante, P G; Merkin, M; Meyer, A; Meyer, J; Miconi, F; Mondal, N K; Muanza, G S; Mulhearn, M; Nagy, E; Naimuddin, M; Narain, M; Nayyar, R; Neal, H A; Negret, J P; Neustroev, P; Novaes, S F; Nunnemann, T; Obrant, G; Orduna, J; Osman, N; Osta, J; Otero y Garzón, G J; Padilla, M; Pal, A; Parashar, N; Parihar, V; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Penning, B; Perfilov, M; Peters, K; Peters, Y; Petridis, K; Petrillo, G; Pétroff, P; Piegaia, R; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Polozov, P; Popov, A V; Prewitt, M; Price, D; Prokopenko, N; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rangel, M S; Ranjan, K; Ratoff, P N; Razumov, I; Renkel, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Rominsky, M; Ross, A; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Salcido, P; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Santos, A S; Savage, G; Sawyer, L; Scanlon, T; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shary, V; Shchukin, A A; Shivpuri, R K; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Smith, K J; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Soustruznik, K; Stark, J; Stolin, V; Stoyanova, D A; Strauss, M; Strom, D; Stutte, L; Suter, L; Svoisky, P; Takahashi, M; Tanasijczuk, A; Taylor, W; Titov, M; Tokmenin, V V; Tsai, Y-T; Tsybychev, D; Tuchming, B; Tully, C; Uvarov, L; Uvarov, S; Uzunyan, S; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vesterinen, M; Vilanova, D; Vokac, P; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, M; Welty-Rieger, L; White, A; Wicke, D; Williams, M R J; Wilson, G W; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Ye, Z; Yin, H; Yip, K; Youn, S W; Yu, J; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L

    2011-09-16

    We present a measurement of the ratio of top quark branching fractions R=B(t→Wb)/B(t→Wq), where q can be a d, s, or b quark, in the lepton+jets and dilepton tt final states. The measurement uses data from 5.4 fb(-1) of pp collisions collected with the D0 detector at the Fermilab Tevatron Collider. We measure R=0.90±0.04, and we extract the Cabibbo-Kobayashi-Maskawa (CKM) matrix element |V(tb)| as |V(tb)|=0.95±0.02, assuming unitarity of the 3×3 CKM matrix.

  13. Precise determination of the deuteron spin structure at low to moderate Q2 with CLAS and extraction of the neutron contribution

    DOE PAGES

    Guler, N.; Fersch, R. G.; Kuhn, S. E.; ...

    2015-11-02

    In this study, we present the final results for the deuteron spin structure functions obtained from the full data set collected with Jefferson Lab's CLAS in 2000-2001. Polarized electrons with energies of 1.6, 2.5, 4.2 and 5.8 GeV were scattered from deuteron (15ND3) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double spin asymmetry, the virtual photon absorption asymmetry Ad1 and the polarized structure function gd1 were extracted over a wide kinematic range (0.05 GeV2 < Q2 < 5 GeV2 and 0.9 GeV < W < 3 GeV). We use an unfolding procedure andmore » a parametrization of the corresponding proton results to extract from these data the polarized structure functions An1 and g1n of the (bound) neutron, which are so far unknown in the resonance region, W < 2 GeV. We compare our final results, including several moments of the deuteron and neutron spin structure functions, with various theoretical models and expectations as well as parametrizations of the world data. The unprecedented precision and dense kinematic coverage of these data can aid in future extractions of polarized parton distributions, tests of perturbative QCD predictions for the quark polarization at large x, a better understanding of quark-hadron duality, and more precise values for higher-twist matrix elements in the framework of the Operator Product Expansion.« less

  14. Precise determination of the deuteron spin structure at low to moderate Q2 with CLAS and extraction of the neutron contribution

    NASA Astrophysics Data System (ADS)

    Guler, N.; Fersch, R. G.; Kuhn, S. E.; Bosted, P.; Griffioen, K. A.; Keith, C.; Minehart, R.; Prok, Y.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Crabb, D.; Crede, V.; D'Angelo, A.; Dashyan, N.; Deur, A.; Djalali, C.; Dodge, G. E.; Dupre, R.; Alaoui, A. El; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Garillon, B.; Garçon, M.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hughes, S. M.; Hyde, C. E.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Livingston, K.; Lu, H. Y.; Mayer, M.; MacGregor, I. J. D.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Movsisyan, A.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Simonyan, A.; Skorodumina, Iu.; Sokhan, D.; Sparveris, N.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Voutier, E.; Walford, N. K.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

    2015-11-01

    We present the final results for the deuteron spin structure functions obtained from the full data set collected in 2000-2001 with Jefferson Lab's continuous electron beam accelerator facility (CEBAF) using the CEBAF large acceptance spectrometer (CLAS). Polarized electrons with energies of 1.6, 2.5, 4.2, and 5.8 GeV were scattered from deuteron (15ND3 ) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double-spin asymmetry, the virtual photon absorption asymmetry A1d and the polarized structure function g1d were extracted over a wide kinematic range (0.05 GeV2extract from these data the polarized structure functions A1n and g1n of the (bound) neutron, which are so far unknown in the resonance region, W <2 GeV. We compare our final results, including several moments of the deuteron and neutron spin structure functions, with various theoretical models and expectations, as well as parametrizations of the world data. The unprecedented precision and dense kinematic coverage of these data can aid in future extractions of polarized parton distributions, tests of perturbative QCD predictions for the quark polarization at large x , a better understanding of quark-hadron duality, and more precise values for higher-twist matrix elements in the framework of the operator product expansion.

  15. COMPARISON OF OFF-LINE IR BUMP AND ACTION-ANGLE KICK MINIMIZATION.

    SciTech Connect

    LUO, Y.; PILAT, F.; PTITSYN, V.; TRBOJEVIC, D.; WEI, J.

    2005-05-16

    The interaction region bump (IR bump) nonlinear correction method has been used for the sextupole and octupole field error on-line corrections in the Relativistic Heavy Ion Collider (RHIC) . Some differences were found for the sextupole and octupole corrector strengths between the on-line IR bump correction and the predictions from the action-angle kick minimization. In this article, we compare the corrector strengths from these two methods based on the RHIC Blue ring lattice with the IR nonlinear modeling. The comparison confirms the differences between resulting corrector strengths. And the reason for the differences is found and discussed.

  16. Growth of silicon bump induced by swift heavy ion at the silicon oxide-silicon interface

    SciTech Connect

    Carlotti, J.-F.; Touboul, A.D.; Ramonda, M.; Caussanel, M.; Guasch, C.; Bonnet, J.; Gasiot, J.

    2006-01-23

    Thin silicon oxide layers on silicon substrates are investigated by scanning probe microscopy before and after irradiation with 210 MeV Au+ ions. After irradiation and complete chemical etching of the silicon oxide layer, silicon bumps grown on the silicon surface are observed. It is shown that each impinging ion induces one silicon bump at the interface. This observation is consistent with the thermal spike theory. Ion energy loss is transferred to the oxide and induces local melting. Silicon-bump formation is favored when the oxide and oxide-silicon interface are silicon rich.

  17. The velocity field created by a shallow bump in a boundary layer

    NASA Technical Reports Server (NTRS)

    Gaster, Michael; Grosch, Chester E.; Jackson, Thomas L.

    1994-01-01

    We report the results of measurements of the disturbance velocity field generated in a boundary layer by a shallow three-dimensional bump oscillating at a very low frequency on the surface of a flat plate. Profiles of the mean velocity, the disturbance velocity at the fundamental frequency and at the first harmonic are presented. These profiles were measured both upstream and downstream of the oscillating bump. Measurements of the disturbance velocity were also made at various spanwise and downstream locations at a fixed distance from the boundary of one displacement thickness. Finally, the spanwise spectrum of the disturbances at three locations downstream of the bump are presented.

  18. Measurement of the ratio σ{tt}/σ{Z/γ{*}→ll} and precise extraction of the tt cross section.

    PubMed

    Aaltonen, T; Adelman, J; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; d'Errico, M; Di Canto, A; di Giovanni, G P; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Dube, S; Ebina, K; Elagin, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Hughes, R E; Hurwitz, M; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Lovas, L; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramanov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Simonenko, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Suh, J S; Sukhanov, A; Suslov, I; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wolfe, H; Wright, T; Wu, X; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhang, X; Zheng, Y; Zucchelli, S

    2010-07-02

    We report a measurement of the ratio of the tt to Z/γ{*} production cross sections in sqrt[s]=1.96  TeV pp collisions using data corresponding to an integrated luminosity of up to 4.6  fb{-1}, collected by the CDF II detector. The tt cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ{*}→ll cross section predicted by the standard model, the extracted tt cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σ{tt}=7.70±0.52  pb, for a top-quark mass of 172.5  GeV/c{2}.

  19. Strongly interacting bumps for the Schroedinger-Newton equations

    SciTech Connect

    Wei Juncheng; Winter, Matthias

    2009-01-15

    We study concentrated bound states of the Schroedinger-Newton equations h{sup 2}{delta}{psi}-E(x){psi}+U{psi}=0, {psi}>0, x(set-membership sign)R{sup 3}; {delta}U+(1/2)|{psi}|{sup 2}=0, x(set-membership sign)R{sup 3}; {psi}(x){yields}0, U(x){yields}0 as |x|{yields}{infinity}. Moroz et al. [''An analytical approach to the Schroedinger-Newton equations,'' Nonlinearity 12, 201 (1999)] proved the existence and uniqueness of ground states of {delta}{psi}-{psi}+U{psi}=0, {psi}>0, x(set-membership sign)R{sup 3}; {delta}U+(1/2)|{psi}|{sup 2}=0, x(set-membership sign)R{sup 3}; {psi}(x){yields}0, U(x){yields}0 as |x|{yields}{infinity}. We first prove that the linearized operator around the unique ground state radial solution ({psi}{sub 0},U{sub 0}) with {psi}{sub 0}(r)=(Ae{sup -r}/r)(1+o(1)) as r=|x|{yields}{infinity}, U{sub 0}(r)=(B/r)(1+o(1)) as r=|x|{yields}{infinity} for some A,B>0 has a kernel whose dimension is exactly 3 (corresponding to the translational modes). Using this result we further show that if for some positive integer K the points P{sub i}(set-membership sign)R{sup 3}, i=1,2...,K, with P{sub i}{ne}P{sub j} for i{ne}j are all local minimum or local maximum or nondegenerate critical points of E(P), then for h small enough there exist solutions of the Schroedinger-Newton equations with K bumps which concentrate at P{sub i}. We also prove that given a local maximum point P{sub 0} of E(P) there exists a solution with K bumps which all concentrate at P{sub 0} and whose distances to P{sub 0} are at least O(h{sup 1/3})

  20. Recent Advances in Understanding the Reminiscence Bump: The Importance of Cues in Guiding Recall from Autobiographical Memory.

    PubMed

    Koppel, Jonathan; Rubin, David C

    2016-04-01

    The reminiscence bump is the increased proportion of autobiographical memories from youth and early adulthood observed in adults over 40. It is one of the most robust findings in autobiographical memory research. Although described as a single period of increased memories, a recent meta-analysis which reported the beginning and ending ages of the bump from individual studies found that different classes of cues produce distinct bumps that vary in size and temporal location. The bump obtained in response to cue words is both smaller and located earlier in the lifespan than the bump obtained when important memories are requested. The bump obtained in response to odor cues is even earlier. This variation in the size and location of the reminiscence bump argues for theories based primarily on retrieval rather than encoding and retention, which most current theories stress. Furthermore, it points to the need to develop theories of autobiographical memory that account for this flexibility in the memories retrieved.

  1. Franz Joseph Gall and music: the faculty and the bump.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking.

  2. Bump hunting in LHC t t ¯ events

    NASA Astrophysics Data System (ADS)

    Czakon, Michal; Heymes, David; Mitov, Alexander

    2016-12-01

    We demonstrate that a purposefully normalized next-to-next-to-leading-order mt t ¯ differential spectrum can have very small theoretical uncertainty and, in particular, a small sensitivity to the top quark mass. Such an observable can thus be a very effective bump-hunting tool for resonances decaying to t t ¯ events during LHC run II and beyond. To illustrate how the approach works, we concentrate on one specific example of current interest, namely, the possible 750 GeV digamma excess resonance Φ . Considering only theoretical uncertainties, we demonstrate that it is possible to distinguish p p →Φ →t t ¯ signals studied in the recent literature [Hespel, Maltoni, and Vryonidou, J. High Energy Phys. 10 (2016) 016, 10.1007/JHEP10(2016)016] from the pure Standard Model background with very high significance. Alternatively, in the case of nonobservation, a strong upper limit on the decay rate Φ →t t ¯ can be placed.

  3. Evaluation of advanced microelectronic fluxless solder-bump contacts for hybrid microcircuits

    NASA Technical Reports Server (NTRS)

    Mandal, R. P.

    1976-01-01

    Technology for interconnecting monolithic integrated circuit chips with other components is investigated. The advantages and disadvantages of the current flip-chip approach as compared to other interconnection methods are outlined. A fluxless solder-bump contact technology is evaluated. Multiple solder-bump contacts were formed on silicon integrated circuit chips. The solder-bumps, comprised of a rigid nickel under layer and a compliant solder overlayer, were electroformed onto gold device pads with the aid of thick dry film photomasks. Different solder alloys and the use of conductive epoxy for bonding were explored. Fluxless solder-bump bond quality and reliability were evaluated by measuring the effects of centrifuge, thermal cycling, and high temperature storage on bond visual characteristics, bond electrical continuity, and bond shear tests. The applicability and suitability of this technology for hybrid microelectronic packaging is discussed.

  4. IPUMS-International High Precision Population Census Microdata Samples: Balancing the Privacy-Quality Tradeoff by Means of Restricted Access Extracts

    PubMed Central

    McCaa, Robert; Ruggles, Steven; Davern, Michael; Swenson, Tami; Palipudi, Krishna Mohan

    2016-01-01

    A breakthrough in the tradeoff between privacy and data quality has been achieved for restricted access to population census microdata samples. The IPUMS-International website, as of June 2006, offers integrated microdata for 47 censuses, totaling more than 140 million person records, with 13 countries represented. Over the next four years, the global collaboratory led by the Minnesota Population Center, with major funding by the United States National Science Foundation and the National Institutes of Health, will disseminate samples for more than 100 additional censuses. The statistical authorities of more than 50 countries have already entrusted microdata to the project under a uniform memorandum of understanding which permits researchers to obtain custom extracts without charge and to analyze the microdata using their own hardware and software. This paper describes the disclosure control methods used by the IPUMS initiative to protect privacy and to provide access to high precision census microdata samples.

  5. Planning and drilling geothermal energy extraction hole EE-2: a precisely oriented and deviated hole in hot granitic rock

    SciTech Connect

    Helmick, C.; Koczan, S.; Pettitt, R.

    1982-04-01

    During the preceding work (Phase I) of the Hot Dry Rock (HDR) Geothermal Energy Project at Fenton Hill, two holes were drilled to a depth of nearly 3048 m (10,000 ft) and connected by a vertical hydraulic fracture. In this phase, water was pumped through the underground reservoir for approximately 417 days, producing an energy equivalent of 3 to 5 MW(t). Energy Extraction Hole No. 2 (EE-2) is the first of two deep holes that will be used in the Engineering-Resource Development System (Phase II) of the ongoing HDR Project of the Los Alamos National Laboratory. This phase of the work consists of drilling two parallel boreholes, inclined in their lower, open-hole sections at 35/sup 0/ to the vertical and separated by a vertical distance of 366 m (1200 ft) between the inclined parts of the drill holes. The holes will be connected by a series of vertical, hydraulically produced fractures in the Precambrian granitic rock complex. EE-2 was drilled to a depth of 4660 m (15,289 ft), where the bottom-hole temperature is approximately 320/sup 0/C (608/sup 0/F). Directional drilling techniques were used to control the azimuth and deviation of the hole. Upgrading of the temperature capability of existing hardware, and development of new equipment was necessary to complete the drilling of the hole in the extremely hot, hard, and abrasive granitic formation. The drilling history and the problems with bits, directional tools, tubular goods, cementing, and logging are described. A discussion of the problems and recommendations for overcoming them are also presented.

  6. Multi-bump solutions in a neural field model with external inputs

    NASA Astrophysics Data System (ADS)

    Ferreira, Flora; Erlhagen, Wolfram; Bicho, Estela

    2016-07-01

    We study the conditions for the formation of multiple regions of high activity or "bumps" in a one-dimensional, homogeneous neural field with localized inputs. Stable multi-bump solutions of the integro-differential equation have been proposed as a model of a neural population representation of remembered external stimuli. We apply a class of oscillatory coupling functions and first derive criteria to the input width and distance, which relate to the synaptic couplings that guarantee the existence and stability of one and two regions of high activity. These input-induced patterns are attracted by the corresponding stable one-bump and two-bump solutions when the input is removed. We then extend our analytical and numerical investigation to N-bump solutions showing that the constraints on the input shape derived for the two-bump case can be exploited to generate a memory of N > 2 localized inputs. We discuss the pattern formation process when either the conditions on the input shape are violated or when the spatial ranges of the excitatory and inhibitory connections are changed. An important aspect for applications is that the theoretical findings allow us to determine for a given coupling function the maximum number of localized inputs that can be stored in a given finite interval.

  7. Composition of structural carbohydrates in biomass: precision of a liquid chromatography method using a neutral detergent extraction and a charged aerosol detector.

    PubMed

    Godin, Bruno; Agneessens, Richard; Gerin, Patrick A; Delcarte, Jérôme

    2011-09-30

    We adapted and optimized a method to quantify the cellulose, hemicellulose, xylan, arabinan, mannan, galactan contents in lignocellulosic biomass. This method is based on a neutral detergent extraction (NDE) of the interfering biomass components, followed by a sulfuric acid hydrolysis (SAH) of the structural polysaccharides, and a liquid chromatography with charged aerosol detection (LC-CAD) to analyze the released monosaccharides. The first step of this NDE-SAH-LC-CAD method aims at removing all compounds that interfere with the subsequent sulphuric acid hydrolysis or with the subsequent chromatographic quantification of the cellulosic and hemicellulosic monosaccharides. This step includes starch hydrolysis with an analytical thermostable α-amylase followed by an extraction of soluble compounds by a Van Soest neutral detergent solution (NDE). The aim of this paper was to assess the precision of this method when choosing fiber sorghum (Sorghum bicolor (L.) Moench), tall fescue (Festuca arundinacea Schreb.) and fiber hemp (Cannabis sativa L.) as representative lignocellulosic biomass. The cellulose content of fiber sorghum, tall fescue and fiber hemp determined by the NDE-SAH-LC-CAD method were 28.7 ± 1.0, 29.7 ± 1.0 and 43.6 ± 1.2g/100g dry matter, respectively, and their hemicellulose content were 18.6 ± 0.5, 16.5 ± 0.5 and 14.5 ± 0.2g/100g dry matter, respectively. Cellulose, mannan and galactan contents were higher in fiber hemp (dicotyledon) as compared to tall fescue and fiber sorghum (monocotyledons). The xylan, arabinan and total hemicellulose contents were higher in tall fescue and fiber sorghum as compared to fiber hemp. The precision of the NDE-SAH-LC-CAD method was better for polysaccharide concentration levels above 1g/100g dry matter. Galactan analysis offered a lower precision, due to a lower CAD response intensity to galactose as compared to the other monosaccharides. The dispersions of the results (expanded uncertainty) of the NDE

  8. Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study.

    PubMed

    Strach, Beata; Wyska, Elżbieta; Pociecha, Krzysztof; Krupa, Anna; Jachowicz, Renata

    2015-10-01

    A sensitive HPLC method was developed and validated for the determination of sildenafil concentrations in rat plasma (200 μL) using a liquid-liquid extraction procedure and paroxetine as an internal standard. In order to eliminate interferences and improve the peak shape, a back-extraction into an acidic solution was utilized. Chromatographic separation was achieved on a cyanopropyl bonded-phase column with a mobile phase composed of 50 m m potassium dihydrogen phosphate buffer (pH 4.5) and acetonitrile (75:25, v/v), pumped at the flow rate of 1 mL/min. A UV detector was set at 230 nm. A calibration curve was constructed within a concentration range from 10 to 1500 ng/mL. The limit of detection was 5 ng/mL. The inter- and intra-day precisions of the assay were in the ranges 2.91-7.33 and 2.61-6.18%, respectively, and the accuracies for inter- and intra-day runs were within 0.14-3.92 and 0.44-2.96%, respectively. The recovery of sildenafil was 85.22 ± 4.54%. Tests confirmed the stability of sildenafil in plasma during three freeze-thaw cycles and during long-term storage at -20 and -80°C for up to 2 months. The proposed method was successfully applied to a pharmacokinetic study in rats.

  9. Inelastic deuteron scattering in the Coulomb nuclear interference region: Procedures for estimating the precision of the extracted B(E2) and B(IS2) values

    SciTech Connect

    Duarte, J.L.; Ukita, G.M.; Borello-Lewin, T.; Horodynski-Matsushigue, L.B.; Gomes, L.C.

    1997-10-01

    Taking {sup 94}Mo(d,d{sup {prime}}){sup 94}Mo(2{sub 1}{sup +}) at 13.2 MeV incident energy as an example, a discussion is made about the influence of known experimental uncertainties in the primary data on the precision of the B(E2) and B(IS2) values, extracted in Coulomb-nuclear interference (CNI) measurements in a correlated way. The reflexes of judicious variations of three optical model parameters (around the global prescription) on the extracted values are also examined. The good quality of the data obtained with the S. Paulo Pelletron-Enge-Spectrograph facility is shown to allow for a 2{endash}3{percent} statistical uncertainty level for these quantities, within a distorted-wave Born approximation-deformed optical model approach. The accuracy of relative values of the ratio B(E2)/B(IS2), which may be linked to the ratio of proton to neutron quadrupole moments, is argued to be of similar order. {copyright} {ital 1997} {ital The American Physical Society}

  10. The σ-bump in elliptical galaxies - a signature of major mergers?

    NASA Astrophysics Data System (ADS)

    Schauer, Anna T. P.; Schulze, Felix; Remus, Rhea-Silvia; Burkert, Andreas

    2017-03-01

    The stellar radial velocity dispersion profiles of elliptical galaxies can be well described by a power-law σ(r)~r -β. We analyze a set of elliptical galaxies formed by major mergers of isolated disk galaxies with mass ratios of 1:1 and 3:1 for several orbital configurations (Johansson et al. 2009). The galaxies in our sample show a deviation from the power-law at 1 - 3R eff, which we term the σ-bump (Schauer et al. 2014). This feature is most prominent in remnants of 1:1 mergers and weakens for remnants of mergers with smaller mass ratios, indicating that the σ-bump is a signature of an equal mass merger. The σ-bump does not vanish with time but stays constant once it has formed, in contrast to shells. It can be seen under all projections, making it an observable feature in the outskirts of elliptical galaxies. We indeed identify three possible σ-bump candidates in the sample of 12 SLUGGS-survey ellipticals studied by Pota et al. (2013), who use globular clusters as tracers for the outer stellar halos (see Schauer et al. 2014, for more details). For further comparisons, we here provide for the first time a two dimensional map of the velocity dispersion of one simulated σ-bump galaxy, to identify the σ-bump in observations of kinematic maps out to several R eff. The σ-bump appears as a global ring-like feature if seen face-on and as an extended box-like feature in its edge-on projection.

  11. Development of an Indium bump bond process for silicon pixel detectors at PSI

    NASA Astrophysics Data System (ADS)

    Broennimann, Ch.; Glaus, F.; Gobrecht, J.; Heising, S.; Horisberger, M.; Horisberger, R.; Kästli, H. C.; Lehmann, J.; Rohe, T.; Streuli, S.

    2006-09-01

    The hybrid pixel detectors used in the high-energy physics experiments currently under construction use a vertical connection technique, the so-called bump bonding. As the pitch below 100 μm, required in these applications, cannot be fulfilled with standard industrial processes (e.g. the IBM C4 process), an in-house bump bond process using reflowed indium bumps was developed at PSI as part of the R&D for the CMS-pixel detector. The bump deposition on the sensor is performed in two subsequent lift-off steps. As the first photolithographic step a thin under bump metalization (UBM) is sputtered onto bump pads. It is wettable by indium and defines the diameter of the bump. The indium is evaporated via a second photolithographic step with larger openings and is reflowed afterwards. The height of the balls is defined by the volume of the indium. On the readout chip only one photolithographic step is carried out to deposit the UBM and a thin indium layer for better adhesion. After mating both parts a second reflow is performed for self-alignment and obtaining high mechanical strength. For the placement of the chips a manual and an automatic machine were constructed. The former is very flexible in handling different chip and module geometries but has a limited throughput while the latter features a much higher grade of automatization and is therefore much more suited for producing hundreds of modules with a well-defined geometry. The reliability of this process was proven by the successful construction of the PILATUS detector. The construction of PILATUS 6M (60 modules) and the CMS pixel barrel (roughly 800 modules) has started in early 2006.

  12. Stress investigation on the rolling tires across the speed bump using finite element method

    NASA Astrophysics Data System (ADS)

    Hidayat, Royan; Pranoto, Sarwo Edy; Tauviqirrahman, Mohammad; Bayuseno, Athanasius P.

    2016-04-01

    The interaction between road surface and tire on a vehicle may strongly determine the vehicle's stability. This study was conducted to find out the stress distribution as a result of pressure on the tires rolling across the speed bumps. This study used Abaqus software to simulate the movement of the tire, which rolls across the speed bump to determine the stress distribution that may occur. The tire component material used was a full path rubber on a speed bump. For the boundary conditions of the study, it was assumed that the tires had load variations as much as 2 kN, 6 kN, 10 kN, as well as pressure variations as much as 17 Psi, 30 Psi, 40 Psi. The tires were then rolled 8 km/h crossing the speed bump. Modeling speed bumps also varied i.e. the first variation of speed bumps that have a height of 50 mm with a width of 250 mm, the second variation of height 75 mm with a width of 300 mm, and a third variation of height 100 mm with a width of 400 mm. The simulation was done by giving the tire pressures as much as 17 Psi, 30 Psi, 40 Psi and loads as much as 2 kN, 6 kN, 10 kN. Further, the tires were rolled three times. It was rolled crossing the first speed bump, the second, and the third, respectively. Results showed stress distribution's fig and graphs. From the analysis results and simulation, it was shown that the greater the load received by the tires, the higher stress they produced.

  13. Pulse Propagation Characteristics of a Multi-layered Printed Circuit Board with a Via and a Bump

    NASA Astrophysics Data System (ADS)

    Kobayashi, Daisuke; Furukawa, Shinichi; Hinata, Takashi

    In this paper, we numerically analyze the transient response of pulse propagation in a multi-layered printed circuit board with a via and a bump. FDTD method is used for our models. It is found from numerical results that; (1) Even if the lengths of the striplines are equal, pulse waveforms passed through a via and a bump are different according to the direction of the striplines. (2) The propagating pulses are influenced by the pad size connecting the bump rather than the bump size. (3) For the model consisted of a via and a bump pulse distortion of responses are substantially improved, if the smaller bump part (including pads) can be designed.

  14. Extraction of CO2 from air samples for isotopic analysis and limits to ultra high precision delta18O determination in CO2 gas.

    PubMed

    Werner, R A; Rothe, M; Brand, W A

    2001-01-01

    be as long as 20 min for high precision delta18O measurements. The presence of traces of air in almost all CO2 gases that we analyzed was another major source of error. Nitrogen and oxygen in the ion source of our mass spectrometer (MAT 252, Finnigan MAT, Bremen, Germany) give rise to the production of NO2 at the hot tungsten filament. NO2+ is isobaric with C16O18O+ (m/z 46) and interferes with the delta18O measurement. Trace amounts of air are present in CO2 extracted cryogenically from air at -196 degrees C. This air, trapped at the cold surface, cannot be pumped away quantitatively. The amount of air present depends on the surface structure and, hence, the alteration of the measured delta18O value varies with the surface conditions. For automated high precision measurement of the isotopic composition of CO2 of air samples stored in glass flasks an extraction interface ('BGC-AirTrap') was developed which allows 18 analyses (including standards) per day to be made. For our reference CO2-in-air, stored in high pressure cylinders, the long term (>9 months) single sample precision was 0.012 per thousand for delta13C and 0.019 per thousand for delta18O.

  15. Enhanced heat transfer surface for cast-in-bump-covered cooling surfaces and methods of enhancing heat transfer

    DOEpatents

    Chiu, Rong-Shi Paul; Hasz, Wayne Charles; Johnson, Robert Alan; Lee, Ching-Pang; Abuaf, Nesim

    2002-01-01

    An annular turbine shroud separates a hot gas path from a cooling plenum containing a cooling medium. Bumps are cast in the surface on the cooling side of the shroud. A surface coating overlies the cooling side surface of the shroud, including the bumps, and contains cooling enhancement material. The surface area ratio of the cooling side of the shroud with the bumps and coating is in excess of a surface area ratio of the cooling side surface with bumps without the coating to afford increased heat transfer across the element relative to the heat transfer across the element without the coating.

  16. DIAGNOSTICS ON THE SOURCE PROPERTIES OF A TYPE II RADIO BURST WITH SPECTRAL BUMPS

    SciTech Connect

    Feng, S. W.; Chen, Y.; Kong, X. L.; Li, G.; Song, H. Q.; Feng, X. S.; Guo, Fan

    2013-04-10

    In recent studies, we proposed that source properties of type II radio bursts can be inferred through a causal relationship between the special shape of the type II dynamic spectrum (e.g., bump or break) and simultaneous extreme ultraviolet (EUV)/white light imaging observations (e.g., CME-shock crossing streamer structures). As a further extension of these studies, in this paper we examine the coronal mass ejection (CME) event on 2007 December 31 associated with a multiple type II radio burst. We identify the presence of two spectral bump features on the observed dynamic spectrum. By combining observational analyses of the radio spectral observations and the EUV-white light imaging data, we conclude that the two spectral bumps result from a CME-shock propagating across dense streamers on the southern and northern sides of the CME. It is inferred that the corresponding two type II emissions originate separately from the two CME-shock flanks where the shock geometries are likely quasi-perpendicular or oblique. Since the emission lanes are bumped as a whole within a relatively short time, it suggests that the type II radio bursts with bumps of this study are emitted from spatially confined sources (with a projected lateral dimension smaller than 0.05-0.1 R{sub Sun} at a fundamental frequency level of 20-30 MHz).

  17. Application of robust color composite fringe in flip-chip solder bump 3-D measurement

    NASA Astrophysics Data System (ADS)

    Kuo, Chung-Feng Jeffrey; Wu, Han-Cheng

    2017-04-01

    This study developed a 3-D measurement system based on flip-chip solder bump, used fringes with different modulation intensities in color channels, in order to produce color composite fringe with robustness, and proposed a multi-channel composite phase unwrapping algorithm, which uses fringe modulation weights of different channels to recombine the phase information for better measurement accuracy and stability. The experimental results showed that the average measurement accuracy is 0.43μm and the standard deviation is 1.38 μm. The results thus proved that the proposed 3-D measurement system is effective in measuring a plane with a height of 50 μm. In the flip-chip solder bump measuring experiment, different fringe modulation configurations were tested to overcome the problem of reflective coefficient between the flip-chip base board and the solder bump. The proposed system has a good measurement results and robust stability in the solder bump measurement, and can be used for the measurement of 3-D information for micron flip-chip solder bump application.

  18. Life scripts for emotionally charged autobiographical memories: A cultural explanation of the reminiscence bump.

    PubMed

    Haque, Shamsul; Hasking, Penelope A

    2010-10-01

    Two studies examined the ability of the life script account to explain the reminiscence bump for emotionally charged autobiographical memories among Malaysian participants. In Study 1 volunteers, aged 50-90 years, participated in a two-phased task. In the first phase, participants estimated the timing of 11 life events (both positive and negative) that may occur in a prototypical life course within their own culture. Two weeks later the participants retrieved the same set of events from their lives and reported how old they were when those events occurred. In the second study 92 undergraduate students produced life scripts for the same 11 events. The findings revealed reminiscence bumps in both life script and retrieval curves for the memories judged happiest, most important, most in love, and most jealous. A reminiscence bump was also noted for success, although this was later in the lifespan than other reminiscence bumps. It was suggested that the life scripts can be used as an alternative account for the reminiscence bump, for highly positive and occasionally for negative autobiographical memories.

  19. On the Application of Contour Bumps for Transonic Drag Reduction(Invited)

    NASA Technical Reports Server (NTRS)

    Milholen, William E., II; Owens, Lewis R.

    2005-01-01

    The effect of discrete contour bumps on reducing the transonic drag at off-design conditions on an airfoil have been examined. The research focused on fully-turbulent flow conditions, at a realistic flight chord Reynolds number of 30 million. State-of-the-art computational fluid dynamics methods were used to design a new baseline airfoil, and a family of fixed contour bumps. The new configurations were experimentally evaluated in the 0.3-m Transonic Cryogenic Tunnel at the NASA Langley Research center, which utilizes an adaptive wall test section to minimize wall interference. The computational study showed that transonic drag reduction, on the order of 12% - 15%, was possible using a surface contour bump to spread a normal shock wave. The computational study also indicated that the divergence drag Mach number was increased for the contour bump applications. Preliminary analysis of the experimental data showed a similar contour bump effect, but this data needed to be further analyzed for residual wall interference corrections.

  20. A gas chromatography/combustion/isotope ratio mass spectrometry system for high-precision delta13C measurements of atmospheric methane extracted from ice core samples.

    PubMed

    Behrens, Melanie; Schmitt, Jochen; Richter, Klaus-Uwe; Bock, Michael; Richter, Ulrike C; Levin, Ingeborg; Fischer, Hubertus

    2008-10-01

    Past atmospheric composition can be reconstructed by the analysis of air enclosures in polar ice cores which archive ancient air in decadal to centennial resolution. Due to the different carbon isotopic signatures of different methane sources high-precision measurements of delta13CH4 in ice cores provide clues about the global methane cycle in the past. We developed a highly automated (continuous-flow) gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS) technique for ice core samples of approximately 200 g. The methane is melt-extracted using a purge-and-trap method, then separated from the main air constituents, combusted and measured as CO2 by a conventional isotope ratio mass spectrometer. One CO2 working standard, one CH4 and two air reference gases are used to identify potential sources of isotope fractionation within the entire sample preparation process and to enhance the stability, reproducibility and accuracy of the measurement. After correction for gravitational fractionation, pre-industrial air samples from Greenland ice (1831 +/- 40 years) show a delta13C(VPDB) of -49.54 +/- 0.13 per thousand and Antarctic samples (1530 +/- 25 years) show a delta13C(VPDB) of -48.00 +/- 0.12 per thousand in good agreement with published data.

  1. A 90 GHz Amplifier Assembled Using a Bump-Bonded InP-Based HEMT

    NASA Technical Reports Server (NTRS)

    Pinsukanjana, Paul R.; Samoska, Lorene A.; Gaier, Todd C.; Smith, R. Peter; Ksendzov, Alexander; Fitzsimmons, Michael J.; Martin, Suzanne C.

    1998-01-01

    We report on the performance of a novel W-band amplifier fabricated utilizing very compact bump bonds. We bump-bonded a high-speed, low-noise InP high electron mobility transistor (HEMT) onto a separately fabricated passive circuit having a GaAs substrate. The compact bumps and small chip size were used for efficient coupling and maximum circuit design flexibility. This new quasi-monolithic millimeter-wave integrated circuit (Q-MMIC) amplifier exhibits a peak gain of 5.8 dB at approx. 90 GHz and a 3 dB bandwidth of greater than 25%. To our knowledge, this is the highest frequency amplifier assembled using bump-bonded technology. Our bump-bonding technique is a useful alternative to the high cost of monolithic millimeter-wave integrated circuits (MMIC's). Effects of the bumps on the circuit appear to be minimal. We used the simple matching circuit for demonstrating the technology - future circuits would have all of the elements (resistors, via holes, bias lines, etc.) included 'in conventional MMIC's. Our design in different from other investigators' efforts in that the bumps are only 8 microns thick by 15 microns wide. The bump sizes were sufficiently small that the devices, originally designed for W-band hybrid circuits, could be bonded without alteration. Figure 3 shows the measured and simulated magnitude of S-parameters from 85-120 GHz, of the InP HEMT bump-bonded to the low noise amplifier (LNA) passive. The maximum gain is 5.8 dB at approx. 90 GHz, and gain extends to 117 GHz. Measurement of a single device (without matching networks) shows approx. 1 dB of gain at 90 GHz. The measured gain of the amplifier agrees well with the design in the center of the measurement band, and the agreement falls off at the band edges. Since no accommodation for the bump-bonding parasitics was made in the design, the result implies that the parasitic elements associated with the bonding itself do not dominate the performance of the LNA circuit. It should be noted that this

  2. Imaging of lumps and bumps in pediatric patients: an algorithm for appropriate imaging and pictorial review.

    PubMed

    Morrow, Michael S; Oliveira, Amy M

    2014-08-01

    Superficial lumps and bumps are a common presenting complaint in the pediatric patient population. Although encountered frequently, the path to a definitive diagnosis is not always a straightforward one. Imaging offers a valuable tool to aid in this diagnostic challenge. Radiologists must be familiar with pediatric lumps and bumps, their imaging characteristics, and the best way to further evaluate challenging clinical presentations. This will not only allow the radiologist to serve as a valuable asset to the treating physician in choosing the most appropriate imaging modality but also help in accurate diagnosis, all while ensuring the "image gently" principle. An algorithm for imaging in the pediatric patient with lumps and bumps has been presented in this article and a few example entities along with their imaging findings have also been reviewed.

  3. Numerical simulation of bump-on-tail instability with source and sink

    SciTech Connect

    Berk, H.L.; Pekker, M.; Breizman, B.N. |

    1995-02-01

    This paper presents results of the simulations of the bump-on-tail instability with a weak source and sink. This problem has been posed as a paradigm for the important problem in controlled fusion, that of the unstable excitation of Alfven waves in a tokamak by resonant energetic alpha particles. The source of alpha particles is the controlled fusion reaction produced by the background plasma and the sink is the collisional transport processes that slow down or scatter the energetic particles. The mathematical techniques that are needed to address this applied problem can be demonstrated in the much simpler bump-on-tail problem, which is explained in this paper.

  4. Trapping saturation of the bump-on-tail instability and electrostatic harmonic excitation in earth's foreshock

    NASA Technical Reports Server (NTRS)

    Klimas, Alexander J.

    1990-01-01

    The Vlasov simulation is used to examine the trapping saturation of the bump-on-tail instability both with and without mode-mode coupling and subsequent harmonic excitation. It is found that adding the pumped harmonic modes leads to a significant difference in the behavior of the phase-space distribution function near the unstable bump at the saturation time of the instability. The pumped modes permit rapid plateau formation on the space-averaged velocity distribution, in effect preventing the onset of the quasi-linear velocity-diffusion saturation mechanism.

  5. The effect of dilution and the use of a post-extraction nucleic acid purification column on the accuracy, precision, and inhibition of environmental DNA samples

    USGS Publications Warehouse

    Mckee, Anna M.; Spear, Stephen F.; Pierson, Todd W.

    2015-01-01

    Isolation of environmental DNA (eDNA) is an increasingly common method for detecting presence and assessing relative abundance of rare or elusive species in aquatic systems via the isolation of DNA from environmental samples and the amplification of species-specific sequences using quantitative PCR (qPCR). Co-extracted substances that inhibit qPCR can lead to inaccurate results and subsequent misinterpretation about a species’ status in the tested system. We tested three treatments (5-fold and 10-fold dilutions, and spin-column purification) for reducing qPCR inhibition from 21 partially and fully inhibited eDNA samples collected from coastal plain wetlands and mountain headwater streams in the southeastern USA. All treatments reduced the concentration of DNA in the samples. However, column purified samples retained the greatest sensitivity. For stream samples, all three treatments effectively reduced qPCR inhibition. However, for wetland samples, the 5-fold dilution was less effective than other treatments. Quantitative PCR results for column purified samples were more precise than the 5-fold and 10-fold dilutions by 2.2× and 3.7×, respectively. Column purified samples consistently underestimated qPCR-based DNA concentrations by approximately 25%, whereas the directional bias in qPCR-based DNA concentration estimates differed between stream and wetland samples for both dilution treatments. While the directional bias of qPCR-based DNA concentration estimates differed among treatments and locations, the magnitude of inaccuracy did not. Our results suggest that 10-fold dilution and column purification effectively reduce qPCR inhibition in mountain headwater stream and coastal plain wetland eDNA samples, and if applied to all samples in a study, column purification may provide the most accurate relative qPCR-based DNA concentrations estimates while retaining the greatest assay sensitivity.

  6. Precision Measurement.

    ERIC Educational Resources Information Center

    Radius, Marcie; And Others

    The manual provides information for precision measurement (counting of movements per minute of a chosen activity) of achievement in special education students. Initial sections give guidelines for the teacher, parent, and student to follow for various methods of charting behavior. It is explained that precision measurement is a way to measure the…

  7. Method to Improve Indium Bump Bonding via Indium Oxide Removal Using a Multi-Step Plasma Process

    NASA Technical Reports Server (NTRS)

    Greer, H. Frank (Inventor); Jones, Todd J. (Inventor); Vasquez, Richard P. (Inventor); Hoenk, Michael E. (Inventor); Dickie, Matthew R. (Inventor); Nikzad, Shouleh (Inventor)

    2012-01-01

    A process for removing indium oxide from indium bumps in a flip-chip structure to reduce contact resistance, by a multi-step plasma treatment. A first plasma treatment of the indium bumps with an argon, methane and hydrogen plasma reduces indium oxide, and a second plasma treatment with an argon and hydrogen plasma removes residual organics. The multi-step plasma process for removing indium oxide from the indium bumps is more effective in reducing the oxide, and yet does not require the use of halogens, does not change the bump morphology, does not attack the bond pad material or under-bump metallization layers, and creates no new mechanisms for open circuits.

  8. Microstructure of lead-free solder bumps using laser reflow soldering

    NASA Astrophysics Data System (ADS)

    Nishikawa, Hiroshi; Iwata, Noriya; Kubota, Shinya

    2014-08-01

    Compared with conventional reflow soldering using a furnace, laser reflow soldering brings advantages such as localized heating, rapid rise and fall in temperature, non-contact soldering and the fact that it is an easily automated process. In this study, to elucidate the characteristics of laser reflow soldering, we investigated the microstructures of a Sn-Ag-Cu solder bump and a Sn-Bi solder bump on a Cu pad after reflow and aging. In the as-soldered condition, we found obvious microstructural refinement and a thin intermetallic compound (IMC) layer at the interface for both the Sn-Ag-Cu solder bump and the Sn-Bi solder bump using laser reflow soldering. Also, during isothermal aging, the total thickness of the IMC layer increased, and a distinct second layer was observed at the interface between the Cu pad and the first layer, regardless of the soldering method. In particular, the growth of the IMC layer was faster in the case of the laser reflow soldering than in the case of the conventional reflow soldering.

  9. Qualification test report bump protection hat (subassembly of T020/M509 head protective assembly)

    NASA Technical Reports Server (NTRS)

    Willis, D. B.

    1972-01-01

    The bump protection hat (BPH) was subjected to impact testing in which it underwent three impacts at 35 foot-pounds of energy. The impacts generated stress cracks, but no penetration. All impacts resulted in deflections of less than one-half inch. It was shown that the BPH is qualified for Skylab and the rescue vehicle.

  10. Photogrammetric 3d Acquisition and Analysis of Medicamentous Induced Pilomotor Reflex ("goose Bumps")

    NASA Astrophysics Data System (ADS)

    Schneider, D.; Hecht, A.

    2016-06-01

    In a current study at the University Hospital Dresden, Department of Neurology, the autonomous function of nerve fibres of the human skin is investigated. For this purpose, a specific medicament is applied on a small area of the skin of a test person which results in a local reaction (goose bumps). Based on the extent of the area, where the stimulation of the nerve fibres is visible, it can be concluded how the nerve function of the skin works. The aim of the investigation described in the paper is to generate 3D data of these goose bumps. Therefore, the paper analyses and compares different photogrammetric surface measurement techniques in regard to their suitability for the 3D acquisition of silicone imprints of the human skin. Furthermore, an appropriate processing procedure for analysing the recorded point cloud data is developed and presented. It was experimentally proven that by using (low-cost) photogrammetric techniques medicamentous induced goose bumps can be acquired in three dimensions and can be analysed almost fully automatically from the perspective of medical research questions. The relative accuracy was determined with 1% (RMSE) of the area resp. the volume of an individual goose bump.

  11. Precision Medicine

    PubMed Central

    Cholerton, Brenna; Larson, Eric B.; Quinn, Joseph F.; Zabetian, Cyrus P.; Mata, Ignacio F.; Keene, C. Dirk; Flanagan, Margaret; Crane, Paul K.; Grabowski, Thomas J.; Montine, Kathleen S.; Montine, Thomas J.

    2017-01-01

    Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease. PMID:26724389

  12. Precision metrology.

    PubMed

    Jiang, X; Whitehouse, D J

    2012-08-28

    This article is a summary of the Satellite Meeting, which followed on from the Discussion Meeting at the Royal Society on 'Ultra-precision engineering: from physics to manufacture', held at the Kavli Royal Society International Centre, Chicheley Hall, Buckinghamshire, UK. The meeting was restricted to 18 invited experts in various aspects of precision metrology from academics from the UK and Sweden, Government Institutes from the UK and Germany and global aerospace industries. It examined and identified metrology problem areas that are, or may be, limiting future developments in precision engineering and, in particular, metrology. The Satellite Meeting was intended to produce a vision that will inspire academia and industry to address the solutions of those open-ended problems identified. The discussion covered three areas, namely the function of engineering parts, their measurement and their manufacture, as well as their interactions.

  13. Enigmatic extinction: An investigation of the 2175 A extinction bump in M101, the Pinwheel Galaxy

    NASA Astrophysics Data System (ADS)

    Danowski, Meredith Elaine

    Dust is a critical component of the universe, affecting energy flow and the dynamics of star and planetary disk evolution. The light we measure when observing the universe is absorbed and scattered (extinguished) by dust. Studies indicate that active formation of high mass stars modifies the ultraviolet (UV) dust extinction curve, removing the characteristic bump at 2175 A. For a half century, the source of this bump has not been positively identified. Dust grain models suggest that a leading contender is polycyclic aromatic hydrocarbons. The spiral galaxy M101 is an ideal laboratory, with many HII regions, plus steep metallicity and ionization gradients. The role of environment in this enigmatic "bump-less'' extinction was investigated in M101 with observations from both a sounding rocket mission and the Hubble Space Telescope (HST).. The Interstellar Absorption Gradient Experiment Rocket (IMAGER) mission was designed to probe the correlations between dust extinction and environment through photometric observations of the apparent strengths of the 2175 A bump and UV continuum in M101. IMAGER flew and collected data on November 21, 2012. Although in-flight anomalies caused significant cross-talk, the mission demonstrated the feasibility of simultaneous imaging in three medium-width UV bands. With angular resolution poorer than one arcminute in all bands, and inadequate signal in the field-of-view, these data proved unsuitable for aperture photometry. This analysis method cannot be used with these data to draw conclusions about the correlations between environment and ultraviolet extinction. Spectroscopic observations were performed with the Space Telescope Imaging Spectrograph (STIS) instrument aboard the HST. With additional data from the Spitzer Space Telescope, and radiative transfer and stellar evolution models, the correlation between the bump and the aromatic features was probed across HII regions spanning wide ranges of metallicity and radiation field

  14. Light curves for bump Cepheids computed with a dynamically zoned pulsation code

    NASA Astrophysics Data System (ADS)

    Adams, T. F.; Castor, J. I.; Davis, C. G.

    1980-05-01

    The dynamically zoned pulsation code developed by Castor, Davis, and Davison was used to recalculate the Goddard model and to calculate three other Cepheid models with the same period (9.8 days). This family of models shows how the bumps and other features of the light and velocity curves change as the mass is varied at constant period. The use of a code that is capable of producing reliable light curves demonstrates that the light and velocity curves for 9.8 day Cepheid models with standard homogeneous compositions do not show bumps like those that are observed unless the mass is significantly lower than the 'evolutionary mass.' The light and velocity curves for the Goddard model presented here are similar to those computed independently by Fischel, Sparks, and Karp. They should be useful as standards for future investigators.

  15. Design, modeling and test of a novel speed bump energy harvester

    NASA Astrophysics Data System (ADS)

    Todaria, Prakhar; Wang, Lirong; Pandey, Abhishek; O'Connor, James; McAvoy, David; Harrigan, Terence; Chernow, Barbara; Zuo, Lei

    2015-04-01

    Speed bumps are commonly used to control the traffic speed and to ensure the safety of pedestrians. This paper proposes a novel speed bump energy harvester (SBEH), which can generate large-scale electrical energy up to several hundred watts when the vehicle drives on it. A unique design of the motion mechanism allows the up-and-down pulse motion to drive the generator into unidirectional rotation, yielding time times more energy than the traditional design. Along with the validation of energy harvesting, this paper also addresses the advantages of this motion mechanism over the traditional design, using physical modeling and simulation. Up to 200 watts electrical peak power in one phase of three-phase generator during in-field test can be regenerated when a sedan passage car passes through the SBEH prototype at 2 km/h.

  16. CFD-Predicted Tile Heating Bump Factors Due to Tile Overlay Repairs

    NASA Technical Reports Server (NTRS)

    Lessard, Victor R.

    2006-01-01

    A Computational Fluid Dynamics investigation of the Orbiter's Tile Overlay Repair (TOR) is performed to assess the aeroheating Damage Assessment Team's (DAT) existing heating correlation method for protuberance interference heating on the surrounding thermal protection system. Aerothermodynamic heating analyses are performed for TORs at the design reference damage locations body points 1800 and 1075 for a Mach 17.9 and a=39deg STS-107 flight trajectory point with laminar flow. Six different cases are considered. The computed peak heating bump factor on the surrounding tiles are below the DAT's heating bump factor values for smooth tile cases. However, for the uneven tiles cases the peak interference heating is shown to be considerably higher than the existing correlation prediction.

  17. Room-Temperature Cu Microjoining with Ultrasonic Bonding of Cone-Shaped Bump

    NASA Astrophysics Data System (ADS)

    Qiu, Lijing; Ikeda, Akihiro; Noda, Kazuhiro; Nakai, Seiya; Asano, Tanemasa

    2013-04-01

    Room-temperature Cu-Cu bonding was realized by applying ultrasonic vibration together with compression force to the bonding of a cone-shaped bump. The size of the bump was about 10 µm. The connection pitch was 20 µm. Mechanical characterization showed that the bonding strength increases with vibration amplitude and depends on the thickness of the counter electrode made of Cu. The thickness dependence of the bonding strength was found to be caused by an increase in the surface roughness of the counter electrode. It was shown that the bonding strength meets the requirement from application to products. Electrical characterization using a daisy-chain connection test demonstrated that more than 10,000 pins on a chip can be connected with a sufficiently low resistance.

  18. Light curves for bump Cepheids computed with a dynamically zoned pulsation code

    NASA Technical Reports Server (NTRS)

    Adams, T. F.; Castor, J. I.; Davis, C. G.

    1980-01-01

    The dynamically zoned pulsation code developed by Castor, Davis, and Davison was used to recalculate the Goddard model and to calculate three other Cepheid models with the same period (9.8 days). This family of models shows how the bumps and other features of the light and velocity curves change as the mass is varied at constant period. The use of a code that is capable of producing reliable light curves demonstrates that the light and velocity curves for 9.8 day Cepheid models with standard homogeneous compositions do not show bumps like those that are observed unless the mass is significantly lower than the 'evolutionary mass.' The light and velocity curves for the Goddard model presented here are similar to those computed independently by Fischel, Sparks, and Karp. They should be useful as standards for future investigators.

  19. Multipole error analysis using local 3-bump orbit data in Fermilab Recycler

    SciTech Connect

    Yang, M.J.; Xiao, M.; /Fermilab

    2005-05-01

    The magnetic harmonic errors of the Fermilab Recycler ring were examined using circulating beam data taken with closed local orbit bumps. Data was first parsed into harmonic orbits of first, second, and third order. Each of which was analyzed for sources of magnetic errors of corresponding order. This study was made possible only with the incredible resolution of a new BPM system that was commissioned after June of 2003.

  20. Effect of overshooting mixing below the base of the convective envelope on the RGB bump

    NASA Astrophysics Data System (ADS)

    Li, Yan

    2015-08-01

    When a low mass star evolves up along the red giant branch (RGB), it will develop much more extensive convection in its envelope. Such envelope convection penetrates rapidly inward into the stellar interior, and finally results in a composition discontinuity when it develops into the chemical gradient region. Subsequently, when the out-moving hydrogen burning-shell encounters the newly-formed composition discontinuity, the star will develops the so-called RGB bump on the HR diagram. Therefore, comparisons of characteristics of the RGB bump are crucial for the overshooting mixing below the base of the stellar convective envelope.In order to treat overshooting convection below the base of the convective envelope, we used the k-omega model of Li (2012) in RGB models of a 1Msun star. We solved equations of the k-omega model in the stellar envelope, and then found that the turbulent kinetic energy and the frequency of turbulence decay in the overshooting region according approximately to power laws of pressure. The decaying indices are found to be sensitive to the parameters of the k-omega model. We adopted a modified overshooting mixing model of Zhang (2013) to investigate the overshooting mixing below the base of the convection zone. We found that the RGB bump appears at a significantly lower luminosity when using the k-omega model than when using the standard mixing-length theory, and its duration is also considerably reduced. Due to extra dredge-up effect of the overshooting mixing, we obtained a little hotter red giant branch using the k-omega model than the one using the standard MLT. We found that the position and duration of the RGB bump sensitively depend on the decaying law of turbulence in the overshooting region. These predictions could be good candidates for asteroseismology of RGB stars.

  1. Blue wings and bumps via Fermi-like acceleration of Ly α photons across shocks

    NASA Astrophysics Data System (ADS)

    Chung, Andrew S.; Dijkstra, Mark; Ciardi, Benedetta; Gronke, Max

    2016-01-01

    We explore the impact of Fermi-like acceleration of Lyman α (Ly α) photons across shock fronts on the observed Ly α spectral line shape. We first confirm the result of Neufeld & McKee (1988) that this mechanism gives rise to extended blue wings which may have been observed in some radio galaxies. Our Monte Carlo radiative transfer calculations further show that in a minor modification of the shell model, in which we add an additional static shell of hydrogen, this process can naturally explain the small blue bumps observed in a subset of Ly α-emitting galaxies, which have been difficult to explain with conventional shell models. Blue bumps can be produced with an additional column density of static hydrogen as small as N^static_{H I} ≪ N^shell_{H I}, and typically occur at roughly the outflow velocity of the shell. In our model the spectra of so-called blue-bump objects might reflect an evolutionary stage in which the outflows regulating the escape of Ly α photons are still engulfed within a static interstellar medium.

  2. Precision translator

    DOEpatents

    Reedy, Robert P.; Crawford, Daniel W.

    1984-01-01

    A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

  3. Precision translator

    DOEpatents

    Reedy, R.P.; Crawford, D.W.

    1982-03-09

    A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

  4. Experiments to measure ablative Richtmyer-Meshkov growth of Gaussian bumps in plastic capsules

    SciTech Connect

    Loomis, Eric; Batha, Steve; Sedillo, Tom; Evans, Scott; Sorce, Chuck; Landen, Otto; Braun, Dave

    2010-06-02

    Growth of hydrodynamic instabilities at the interfaces of inertial confinement fusion capsules (ICF) due to ablator and fuel non-uniformities have been of primary concern to the ICF program since its inception. To achieve thermonuclear ignition at Megajoule class laser systems such as the NIF, targets must be designed for high implosion velocities, which requires higher in-flight aspect ratios (IFAR) and diminished shell stability. Controlling capsule perturbations is thus of the utmost importance. Recent simulations have shown that features on the outer surface of an ICF capsule as small as 10 microns wide and 100's of nanometers tall such as bumps, divots, or even dust particles can profoundly impact capsule performance by leading to material jetting or mix into the hotspot. Recent x-ray images of implosions on the NIF may be evidence of such mixing. Unfortunately, our ability to accurately predict these effects is uncertain due to disagreement between equation of state (EOS) models. In light of this, we have begun a campaign to measure the growth of isolated defects (Gaussian bumps) due to ablative Richtmyer-Meshkov in CH capsules to validate these models. The platform that has been developed uses halfraums with radiation temperatures near 75 eV (Rev. 4 foot-level) driven by 15-20 beams from the Omega laser (Laboratory for Laser Energetics, University of Rochester, NY), which sends a ~2.5 Mbar shock into a planar CH foil. Gaussian-shaped bumps (20 microns wide, 4-7 microns tall) are deposited onto the ablation side of the target. On-axis radiography with a saran (Cl Heα - 2.8 keV) backlighter is used to measure bump evolution prior to shock breakout. Shock speed measurements will also be made with Omega's active shock breakout (ASBO) and streaked optical pyrometery (SOP) diagnostics in conjunction with filtered x-ray photodiode arrays (DANTE) to determine drive conditions in the target. These data will be used to discriminate between EOS models so

  5. Effects of PCB Pad Metal Finishes on the Cu-Pillar/Sn-Ag Micro Bump Joint Reliability of Chip-on-Board (COB) Assembly

    NASA Astrophysics Data System (ADS)

    Kim, Youngsoon; Lee, Seyong; Shin, Ji-won; Paik, Kyung-Wook

    2016-06-01

    While solder bumps have been used as the bump structure to form the interconnection during the last few decades, the continuing scaling down of devices has led to a change in the bump structure to Cu-pillar/Sn-Ag micro-bumps. Cu-pillar/Sn-Ag micro-bump interconnections differ from conventional solder bump interconnections in terms of their assembly processing and reliability. A thermo-compression bonding method with pre-applied b-stage non-conductive films has been adopted to form solder joints between Cu pillar/Sn-Ag micro bumps and printed circuit board vehicles, using various pad metal finishes. As a result, various interfacial inter-metallic compounds (IMCs) reactions and stress concentrations occur at the Cu pillar/Sn-Ag micro bumps joints. Therefore, it is necessary to investigate the influence of pad metal finishes on the structural reliability of fine pitch Cu pillar/Sn-Ag micro bumps flip chip packaging. In this study, four different pad surface finishes (Thin Ni ENEPIG, OSP, ENEPIG, ENIG) were evaluated in terms of their interconnection reliability by thermal cycle (T/C) test up to 2000 cycles at temperatures ranging from -55°C to 125°C and high-temperature storage test up to 1000 h at 150°C. The contact resistances of the Cu pillar/Sn-Ag micro bump showed significant differences after the T/C reliability test in the following order: thin Ni ENEPIG > OSP > ENEPIG where the thin Ni ENEPIG pad metal finish provided the best Cu pillar/Sn-Ag micro bump interconnection in terms of bump joint reliability. Various IMCs formed between the bump joint areas can account for the main failure mechanism.

  6. HUBBLE SPACE TELESCOPE MORPHOLOGIES OF z {approx} 2 DUST-OBSCURED GALAXIES. II. BUMP SOURCES

    SciTech Connect

    Bussmann, R. S.; Dey, Arjun; Lotz, J.; Jannuzi, B. T.; Armus, L.; Desai, V.; Soifer, B. T.; Brown, M. J. I.; Eisenhardt, P.; Higdon, J.; Higdon, S.; Le Floc'h, E.; Melbourne, J.; Weedman, D.

    2011-05-20

    We present Hubble Space Telescope imaging of 22 ultra-luminous infrared galaxies (ULIRGs) at z {approx} 2 with extremely red R - [24] colors (called dust-obscured galaxies, or DOGs) which have a local maximum in their spectral energy distribution (SED) at rest-frame 1.6 {mu}m associated with stellar emission. These sources, which we call 'bump DOGs', have star formation rates (SFRs) of 400-4000 M{sub sun} yr{sup -1} and have redshifts derived from mid-IR spectra which show strong polycyclic aromatic hydrocarbon emission-a sign of vigorous ongoing star formation. Using a uniform morphological analysis, we look for quantifiable differences between bump DOGs, power-law DOGs (Spitzer-selected ULIRGs with mid-IR SEDs dominated by a power law and spectral features that are more typical of obscured active galactic nuclei than starbursts), submillimeter-selected galaxies, and other less-reddened ULIRGs from the Spitzer Extragalactic First Look Survey. Bump DOGs are larger than power-law DOGs (median Petrosian radius of 8.4 {+-} 2.7 kpc versus 5.5 {+-} 2.3 kpc) and exhibit more diffuse and irregular morphologies (median M{sub 20} of -1.08 {+-} 0.05 versus -1.48 {+-} 0.05). These trends are qualitatively consistent with expectations from simulations of major mergers in which merging systems during the peak SFR period evolve from M{sub 20} = -1.0 to M{sub 20} = -1.7. Less-obscured ULIRGs (i.e., non-DOGs) tend to have more regular, centrally peaked, single-object morphologies rather than diffuse and irregular morphologies. This distinction in morphologies may imply that less-obscured ULIRGs sample the merger near the end of the peak SFR period. Alternatively, it may indicate that the intense star formation in these less-obscured ULIRGs is not the result of a recent major merger.

  7. Eyelid bump

    MedlinePlus

    ... cause trouble with your vision. If you have blepharitis , you are more likely to get styes. Other ... you are prone to getting styes or have blepharitis, it may help to carefully clean off excess ...

  8. An assessment of the potential for a steam bump in Hanford Waste Tank 241-C-106

    SciTech Connect

    Bander, T.J.; Crea, B.

    1994-09-28

    This document is a preliminary assessment of the potential for a ``steam bump`` in Tank 241-C-106. The assessment is based on currently available data from significant transients which occurred in Tank C-106. Recommendations are made for additional data needs to clarify the current behavior of this tank. General criteria are provided for making decisions on removing or returning to work restrictions on Tank Farm operations. Also provided are additional actions which should be taken on C-106 to manage tank heat removal.

  9. Interpretation of the gamma-ray bump from Cygnus X-1

    NASA Technical Reports Server (NTRS)

    Liang, Edison P.; Dermer, Charles D.

    1988-01-01

    The strong 0.5-2 MeV gamma-ray bump of Cyg X-1 recently reported by HEAO 3 observers can be interpreted self-consistently as the emission from a hot (kT of about 400 keV) pair-dominated plasma. The emission region parameters are uniquely determined by the spectral fit and observed luminosity via the pair-balance condition, suggesting that the gamma rays are produced in the inner region of the accretion flow at the expense of the normal power-law hard X-rays.

  10. Unsteady features of the flow on a bump in transonic environment

    NASA Astrophysics Data System (ADS)

    Budovsky, A. D.; Sidorenko, A. A.; Polivanov, P. A.; Vishnyakov, O. I.; Maslov, A. A.

    2016-10-01

    The study deals with experimental investigation of unsteady features of separated flow on a profiled bump in transonic environment. The experiments were conducted in T-325 wind tunnel of ITAM for the following flow conditions: P0 = 1 bar, T0 = 291 K. The base flow around the model was studied by schlieren visualization, steady and unsteady wall pressure measurements and PIV. The experimentally data obtained using PIV are analyzed by Proper Orthogonal Decomposition (POD) technique to investigate the underlying unsteady flow organization, as revealed by the POD eigenmodes. The data obtained show that flow pulsations revealed upstream and downstream of shock wave are correlated and interconnected.

  11. Precise Extraction of the Neutron Magnetic Form Factor from Quasi-elastic 3He(pol)(e(pol),e') at Q^2 = 0.1-0.6 (GeV/c)^2

    SciTech Connect

    Jens-ole Hansen; Brian Anderson; Leonard Auerbach; Todd Averett; William Bertozzi; Tim Black; John Calarco; Lawrence Cardman; Gordon Cates; Zhengwei Chai; Jiang-Ping Chen; Seonho Choi; Eugene Chudakov; Steve Churchwell; G Corrado; Christopher Crawford; Daniel Dale; Alexandre Deur; Pibero Djawotho; Dipangkar Dutta; John Finn; Haiyan Gao; Ronald Gilman; Oleksandr Glamazdin; Charles Glashausser; Walter Gloeckle; Jacek Golak; Javier Gomez; Viktor Gorbenko; F. Hersman; Douglas Higinbotham; Richard Holmes; Calvin Howell; Emlyn Hughes; Thomas Humensky; Sebastien Incerti; Piotr Zolnierczuk; Cornelis De Jager; John Jensen; Xiaodong Jiang; Cathleen Jones; Mark Jones; R Kahl; H Kamada; A Kievsky; Ioannis Kominis; Wolfgang Korsch; Kevin Kramer; Gerfried Kumbartzki; Michael Kuss; Enkeleida Lakuriqi; Meihua Liang; Nilanga Liyanage; John LeRose; Sergey Malov; Demetrius Margaziotis; Jeffery Martin; Kathy McCormick; Robert McKeown; Kevin McIlhany; Zein-Eddine Meziani; Robert Michaels; Greg Miller; Joseph Mitchell; Sirish Nanda; Emanuele Pace; Tina Pavlin; Gerassimos Petratos; Roman Pomatsalyuk; David Pripstein; David Prout; Ronald Ransome; Yves Roblin; Marat Rvachev; Giovanni Salme; Michael Schnee; Charles Seely; Taeksu Shin; Karl Slifer; Paul Souder; Steffen Strauch; Riad Suleiman; Mark Sutter; Bryan Tipton; Luminita Todor; M Viviani; Branislav Vlahovic; John Watson; Claude Williamson; H Witala; Bogdan Wojtsekhowski; Feng Xiong; Wang Xu; Jen-chuan Yeh

    2006-05-05

    We have measured the transverse asymmetry A{sub T'} in the quasi-elastic {sup 3}/rvec He/(/rvec e/,e') process with high precision at Q{sup 2}-values from 0.1 to 0.6 (GeV/c){sup 2}. The neutron magnetic form factor G{sub M}{sup n} was extracted at Q{sup 2}-values of 0.1 and 0.2 (GeV/c){sup 2} using a non-relativistic Faddeev calculation which includes both final-state interactions (FSI) and meson-exchange currents (MEC). Theoretical uncertainties due to the FSI and MEC effects were constrained with a precision measurement of the spin-dependent asymmetry in the threshold region of {sup 3}/rvec He/(/rvec e/,e'). We also extracted the neutron magnetic form factor G{sub M}{sup n} at Q{sup 2}-values of 0.3 to 0.6 (GeV/c){sup 2} based on Plane Wave Impulse Approximation calculations.

  12. Precise determination of the deuteron spin structure at low to moderate Q2 with CLAS and extraction of the neutron contribution

    SciTech Connect

    Guler, N.; Fersch, R. G.; Kuhn, S. E.; Bosted, P.; Griffioen, K. A.; Keith, C.; Minehart, R.; Prok, Y.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Crabb, D.; Crede, V.; D'Angelo, A.; Dashyan, N.; Deur, A.; Djalali, C.; Dodge, G. E.; Dupre, R.; Alaoui, A. El; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Garillon, B.; Garçon, M.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hughes, S. M.; Hyde, C. E.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Livingston, K.; Lu, H. Y.; Mayer, M.; MacGregor, I. J. D.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Movsisyan, A.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Simonyan, A.; Skorodumina, Iu.; Sokhan, D.; Sparveris, N.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Voutier, E.; Walford, N. K.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2015-11-02

    In this study, we present the final results for the deuteron spin structure functions obtained from the full data set collected with Jefferson Lab's CLAS in 2000-2001. Polarized electrons with energies of 1.6, 2.5, 4.2 and 5.8 GeV were scattered from deuteron (15ND3) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double spin asymmetry, the virtual photon absorption asymmetry Ad1 and the polarized structure function gd1 were extracted over a wide kinematic range (0.05 GeV2 < Q2 < 5 GeV2 and 0.9 GeV < W < 3 GeV). We use an unfolding procedure and a parametrization of the corresponding proton results to extract from these data the polarized structure functions An1 and g1n of the (bound) neutron, which are so far unknown in the resonance region, W < 2 GeV. We compare our final results, including several moments of the deuteron and neutron spin structure functions, with various theoretical models and expectations as well as parametrizations of the world data. The unprecedented precision and dense kinematic coverage of these data can aid in future extractions of polarized parton distributions, tests of perturbative QCD predictions for the quark polarization at large x, a better understanding of quark-hadron duality, and more precise values for higher-twist matrix elements in the framework of the Operator Product Expansion.

  13. Initial test results of the Los Alamos proton-storage-ring bump-magnet system

    SciTech Connect

    Rose, C.R.; Barlow, D.B.; Redd, D.B.

    1997-09-01

    An upgrade program for increasing the stored beam current in the LANSCE Proton Storage is presently under way. Part of the upgrade effort has been to design, specify, and add four bump-magnet/modulator systems to the ring. This paper describes the initial test results of the first bump-magnet/modulator system. The paper begins with an overview of the pulsed-power system including important specifications of the modulator, magnet, cabling, and control system. In the main portion of the paper, waveforms and test data are included showing the accuracy, repeatability, and stability of the magnet-current pulses. These magnet pulses are programmable both in rise and fall time as well as in amplitude. The amplitude can be set between 50 and 300 A, the rise-time is fixed at 1 ms, and the linear fall-time can be varied between 500 {mu}s and 1500 {mu}s. Other issues such as loading effects and power dissipation in the magnet-bore beamtube are examined and reported.

  14. R package PRIMsrc: Bump Hunting by Patient Rule Induction Method for Survival, Regression and Classification.

    PubMed

    Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J Sunil

    2015-08-01

    PRIMsrc is a novel implementation of a non-parametric bump hunting procedure, based on the Patient Rule Induction Method (PRIM), offering a unified treatment of outcome variables, including censored time-to-event (Survival), continuous (Regression) and discrete (Classification) responses. To fit the model, it uses a recursive peeling procedure with specific peeling criteria and stopping rules depending on the response. To validate the model, it provides an objective function based on prediction-error or other specific statistic, as well as two alternative cross-validation techniques, adapted to the task of decision-rule making and estimation in the three types of settings. PRIMsrc comes as an open source R package, including at this point: (i) a main function for fitting a Survival Bump Hunting model with various options allowing cross-validated model selection to control model size (#covariates) and model complexity (#peeling steps) and generation of cross-validated end-point estimates; (ii) parallel computing; (iii) various S3-generic and specific plotting functions for data visualization, diagnostic, prediction, summary and display of results. It is available on CRAN and GitHub.

  15. Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

    SciTech Connect

    Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.; Hollenbeck, Scott

    2015-01-27

    We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The method consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.

  16. Miniaturization of Micro-Solder Bumps and Effect of IMC on Stress Distribution

    NASA Astrophysics Data System (ADS)

    Choudhury, Soud Farhan; Ladani, Leila

    2016-07-01

    As the joints become smaller in more advanced packages and devices, intermetallic (IMCs) volume ratio increases, which significantly impacts the overall mechanical behavior of joints. The existence of only a few grains of Sn (Tin) and IMC materials results in anisotropic elastic and plastic behavior which is not detectable using conventional finite element (FE) simulation with average properties for polycrystalline material. In this study, crystal plasticity finite element (CPFE) simulation is used to model the whole joint including copper, Sn solder and Cu6Sn5 IMC material. Experimental lap-shear test results for solder joints from the literature were used to validate the models. A comparative analysis between traditional FE, CPFE and experiments was conducted. The CPFE model was able to correlate the experiments more closely compared to traditional FE analysis because of its ability to capture micro-mechanical anisotropic behavior. Further analysis was conducted to evaluate the effect of IMC thickness on stress distribution in micro-bumps using a systematic numerical experiment with IMC thickness ranging from 0% to 80%. The analysis was conducted on micro-bumps with single crystal Sn and bicrystal Sn. The overall stress distribution and shear deformation changes as the IMC thickness increases. The model with higher IMC thickness shows a stiffer shear response, and provides a higher shear yield strength.

  17. R package PRIMsrc: Bump Hunting by Patient Rule Induction Method for Survival, Regression and Classification

    PubMed Central

    Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

    2015-01-01

    PRIMsrc is a novel implementation of a non-parametric bump hunting procedure, based on the Patient Rule Induction Method (PRIM), offering a unified treatment of outcome variables, including censored time-to-event (Survival), continuous (Regression) and discrete (Classification) responses. To fit the model, it uses a recursive peeling procedure with specific peeling criteria and stopping rules depending on the response. To validate the model, it provides an objective function based on prediction-error or other specific statistic, as well as two alternative cross-validation techniques, adapted to the task of decision-rule making and estimation in the three types of settings. PRIMsrc comes as an open source R package, including at this point: (i) a main function for fitting a Survival Bump Hunting model with various options allowing cross-validated model selection to control model size (#covariates) and model complexity (#peeling steps) and generation of cross-validated end-point estimates; (ii) parallel computing; (iii) various S3-generic and specific plotting functions for data visualization, diagnostic, prediction, summary and display of results. It is available on CRAN and GitHub. PMID:26798326

  18. Biomimetic Water-Collecting Fabric with Light-Induced Superhydrophilic Bumps.

    PubMed

    Wang, Yuanfeng; Wang, Xiaowen; Lai, Chuilin; Hu, Huawen; Kong, Yeeyee; Fei, Bin; Xin, John H

    2016-02-10

    To develop an efficient water-collecting surface that integrates both fast water-capturing and easy drainage properties is of high current interest for addressing global water issues. In this work, a superhydrophobic surface was fabricated on cotton fabric via manipulation of both the surface roughness and surface energy. This was followed by a subsequent spray coating of TiO2 nanosol that created light-induced superhydrophilic bumps with a unique raised structure as a result of the interfacial tension of the TiO2 nanosol sprayed on the superhydrophobic fiber surface. These raised TiO2 bumps induce both a wettability gradient and a shape gradient, synergistically accelerating water coalescence and water collection. The in-depth study revealed that the quantity and the distribution of the TiO2 had a significant impact on the final water collection efficiency. This inexpensive and facilely fabricated fabric biomimicks the desert beetle's back and spider silk, which are capable of fog harvesting without additional energy consumption.

  19. Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing.

    PubMed

    Jankovic, John; Zontek, Tracy L; Ogle, Burton R; Hollenbeck, Scott

    2015-01-01

    The calibration records of two direct reading instruments designated as condensation particle counters were examined to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. Both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Therefore, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The method consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. The bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.

  20. Viscoplasticity Behavior of a Solder Joint on a Drilled Cu Pillar Bump Under Thermal Cycling Using FEA

    NASA Astrophysics Data System (ADS)

    Kwon, Yong-Hyuk; Bang, Hee-Seon; Bang, Han-Sur

    2017-02-01

    Although the copper (Cu) pillar bump (CPB) was developed in accordance with recent trends of miniaturized, multifunctional, and high-performance technology, its thermomechanical reliability remains in question. Accordingly, a hole was drilled into a CPB to increase its thermomechanical reliability, and the viscoplasticity behaviors of the two structures were subsequently compared through finite element analysis. In particular, this study applied the Anand model, which addresses both plastic strain and creep strain, as well as a submodeling technique to increase the accuracy of the analysis and decrease the analysis time. In addition, this study confirmed the superiority of the thermomechanical reliability of drilled Cu pillar bump through a hysteresis loop, which showed the equivalent stress versus equivalent inelastic strain of the solder joint interfaces. Moreover, the study compared the inelastic strain energy density values. The results demonstrated that the drilled copper pillar bump does indeed have a smaller inelastic range and a lower inelastic strain energy density.

  1. Measurement of the Ratio σtt¯/σZ/γ*→ll and Precise Extraction of the tt¯ Cross Section

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Beecher, D.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Calancha, C.; Camarda, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Chung, K.; Chung, W. H.; Chung, Y. S.; Chwalek, T.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Crescioli, F.; Cuenca Almenar, C.; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lorenzo, G.; Dell'Orso, M.; Deluca, C.; Demortier, L.; Deng, J.; Deninno, M.; D'Errico, M.; di Canto, A.; di Giovanni, G. P.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Dorigo, T.; Dube, S.; Ebina, K.; Elagin, A.; Erbacher, R.; Errede, D.; Errede, S.; Ershaidat, N.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Frank, M. J.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerdes, D.; Gessler, A.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; Guimaraes da Costa, J.; Gunay-Unalan, Z.; Haber, C.; Hahn, S. R.; Halkiadakis, E.; Han, B.-Y.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harr, R. F.; Hartz, M.; Hatakeyama, K.; Hays, C.; Heck, M.; Heinrich, J.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Hughes, R. E.; Hurwitz, M.; Husemann, U.; Hussein, M.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jha, M. K.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Ketchum, W.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, H. W.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kuhr, T.; Kulkarni, N. P.; Kurata, M.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, E.; Lee, H. S.; Lee, J. S.; Lee, S. W.; Leone, S.; Lewis, J. D.; Lin, C.-J.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, T.; Lockyer, N. S.; Loginov, A.; Lovas, L.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Mastrandrea, P.; Mathis, M.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzione, A.; Mesropian, C.; Miao, T.; Mietlicki, D.; Miladinovic, N.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moed, S.; Moggi, N.; Mondragon, M. N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlock, J.; Movilla Fernandez, P.; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Neubauer, M. S.; Neubauer, S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Osterberg, K.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramanov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Peiffer, T.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Potamianos, K.; Poukhov, O.; Prokoshin, F.; Pronko, A.; Ptohos, F.; Pueschel, E.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Renton, P.; Renz, M.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Rutherford, B.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Santi, L.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, A.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sforza, F.; Sfyrla, A.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shiraishi, S.; Shochet, M.; Shon, Y.; Shreyber, I.; Simonenko, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soha, A.; Somalwar, S.; Sorin, V.; Squillacioti, P.; Stanitzki, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Strycker, G. L.; Suh, J. S.; Sukhanov, A.; Suslov, I.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thome, J.; Thompson, G. A.; Thomson, E.; Tipton, P.; Ttito-Guzmán, P.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Tourneur, S.; Trovato, M.; Tsai, S.-Y.; Tu, Y.; Turini, N.; Ukegawa, F.; Uozumi, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Vidal, M.; Vila, I.; Vilar, R.; Vogel, M.; Volobouev, I.; Volpi, G.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner, W.; Wagner-Kuhr, J.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Weinelt, J.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Wilbur, S.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wolfe, H.; Wright, T.; Wu, X.; Würthwein, F.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanetti, A.; Zeng, Y.; Zhang, X.; Zheng, Y.; Zucchelli, S.; CDF Collaboration

    2010-07-01

    We report a measurement of the ratio of the tt¯ to Z/γ* production cross sections in s=1.96TeV pp¯ collisions using data corresponding to an integrated luminosity of up to 4.6fb-1, collected by the CDF II detector. The tt¯ cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ*→ll cross section predicted by the standard model, the extracted tt¯ cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σtt¯=7.70±0.52pb, for a top-quark mass of 172.5GeV/c2.

  2. Ultra-fast Movies Resolve Ultra-short Pulse Laser Ablation and Bump Formation on Thin Molybdenum Films

    NASA Astrophysics Data System (ADS)

    Domke, Matthias; Rapp, Stephan; Huber, Heinz

    For the monolithic serial interconnection of CIS thin film solar cells, 470 nm molybdenum films on glass substrates must be separated galvanically. The single pulse ablation with a 660 fs laser at a wavelength of 1053 nm is investigated in a fluence regime from 0.5 to 5.0 J/cm2. At fluences above 2.0 J/cm2 bump and jet formation can be observed that could be used for creating microstructures. For the investigation of the underlying mechanisms of the laser ablation process itself as well as of the bump or jet formation, pump probe microscopy is utilized to resolve the transient ablation behavior.

  3. Histochemical technique: a general method for quantitative enzyme assays of single cell extracts with a time resolution of seconds and a reading precision of femtomoles

    SciTech Connect

    Outlaw, W.H. Jr.; Springer, S.A.; Tarczynski, M.C.

    1985-03-01

    Biochemists who study single cells have been constrained by the lack of a general methodology of high time resolution and high measurement sensitivity for quantitatively assaying enzyme activities using natural substrates in solution. The methods the authors describe will remove this limitation. In brief, nanogram tissue samples are dissected from frozen-dried tissue. The samples are extracted in microdroplets of assay cocktail. The enzyme activity, indicated fluorometrically by the oxidation/reduction of NAD(P), is followed in real time on a computer display. With these methods, assays of pyruvate orthophosphate dikinase on samples enriched in bundlesheath cells and mesophyll cells of Flaveria brownii yielded the predictable results. Assays of this enzyme in guard cells dissected from Vicia faba leaflets gave results like those recently reported by another laboratory for protoplasts derived from these cells. The results of assays by this method and by enzymic cycling for NAD(P) triose-P dehydrogenase were comparable. Phosphoenolpyruvate carboxylase, the most extensively studied enzyme activity, was present at high levels in guard cells, which has been demonstrated previously in other reports based on diverse assay approaches.

  4. Development of a reliable analytical method for the precise extractive spectrophotometric determination of osmium(VIII) with 2-nitrobenzaldehydethiocarbohydrazone: Analysis of alloys and real sample

    NASA Astrophysics Data System (ADS)

    Zanje, Sunil B.; Kokare, Arjun N.; Suryavanshi, Vishal J.; Waghmode, Duryodhan P.; Joshi, Sunil S.; Anuse, Mansing A.

    2016-12-01

    The proposed method demonstrates that the osmium(VIII) forms complex with 2-NBATCH from 0.8 mol L- 1 HCl at room temperature. The complex formed was extracted in 10 mL of chloroform with a 5 min equilibration time. The absorbance of the red colored complex was measured at 440 nm against the reagent blank. The Beer's law was obeyed in the range of 5-25 μg mL- 1, the optimum concentration range was 10-20 μg mL- 1 of osmium(VIII) as evaluated by Ringbom's plot. Molar absorptivity and Sandell's sensitivity of osmium(VIII)-2NBATCH complex in chloroform is 8.94 × 103 L mol- 1 cm- 1 and 0.021 μg cm- 2, respectively. The composition of osmium(VIII)-2NBATCH complex was 1:2 investigated from Job's method of continuous variation, Mole ratio method and slope ratio method. The interference of diverse ions was studied and masking agents were used wherever necessary. The present method was successfully applied for determination of osmium(VIII) from binary, ternary and synthetic mixtures corresponding to alloys and real samples. The validity of the method was confirmed by finding the relative standard deviation for five determinations which was 0.29%.

  5. Development of a reliable analytical method for the precise extractive spectrophotometric determination of osmium(VIII) with 2-nitrobenzaldehydethiocarbohydrazone: Analysis of alloys and real sample.

    PubMed

    Zanje, Sunil B; Kokare, Arjun N; Suryavanshi, Vishal J; Waghmode, Duryodhan P; Joshi, Sunil S; Anuse, Mansing A

    2016-12-05

    The proposed method demonstrates that the osmium(VIII) forms complex with 2-NBATCH from 0.8molL(-1) HCl at room temperature. The complex formed was extracted in 10mL of chloroform with a 5min equilibration time. The absorbance of the red colored complex was measured at 440nm against the reagent blank. The Beer's law was obeyed in the range of 5-25μgmL(-1), the optimum concentration range was 10-20μgmL(-1) of osmium(VIII) as evaluated by Ringbom's plot. Molar absorptivity and Sandell's sensitivity of osmium(VIII)-2NBATCH complex in chloroform is 8.94×10(3)Lmol(-1)cm(-1) and 0.021μgcm(-2), respectively. The composition of osmium(VIII)-2NBATCH complex was 1:2 investigated from Job's method of continuous variation, Mole ratio method and slope ratio method. The interference of diverse ions was studied and masking agents were used wherever necessary. The present method was successfully applied for determination of osmium(VIII) from binary, ternary and synthetic mixtures corresponding to alloys and real samples. The validity of the method was confirmed by finding the relative standard deviation for five determinations which was 0.29%.

  6. First Measurement of the Ratio sigma_(t-tbar) / sigma_(Z/\\gamma*->ll) and Precise Extraction of the t-tbar Cross Section

    SciTech Connect

    Aaltonen, T.; Adelman, J.; Alvarez Gonzalez, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; /Waseda U. /Dubna, JINR

    2010-04-01

    We report a measurement of the ratio of the t{bar t} to Z/{gamma}* production cross sections in {radical}s = 1.96 TeV p{bar p} collisions using data corresponding to an integrated luminosity of up to 4.6 fb{sup -1}, collected by the CDF II detector. The t{bar t} cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/{gamma}* {yields} ll cross section predicted by the standard model, the extracted t{bar t} cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result {sigma}{sub t{bar t}} = 7.70 {+-} 0.52 pb, for a top-quark mass of 172.5 GeV/c{sup 2}.

  7. Solderjet Bumping as a Versatile Tool for the Integration of Piezoelectric Deformable Mirrors

    NASA Astrophysics Data System (ADS)

    Burkhardt, Thomas; Goy, Matthias; Hornaff, Marcel; Appelfelder, Michael; Reinlein, Claudia

    A deformable mirror (DM) is a device that aims to compensate laser-induced mirror deformation and thermal lensing in the optical system. The mounting of membrane based DM with screen-printed actuators is crucial, as stress may deform the membrane and change their characteristics (shape, piezoelectric deflection, natural frequency). We present the laser-based Solderjet Bumping (SJB) technique to assemble mounts for piezoelectric-activated DM. The discussed polymer-free joining offers advantages, such as improved temporal stability and low outgassing, over adhesive bonding. We evaluate the optimum number of solder joints with respect to resonance behavior by finite elements analysis and experimental measurements. Long-term evaluation over a period of more than four years shows no significant change of resonance behavior. Thus, we prove the SJB bonding technique to be stable for dynamic applications over several years, and consider it a versatile tool for integration of DM.

  8. Interfacial Reaction Characteristics of Au Stud/Sn/Cu Pillar Bump During Annealing and Current Stressing.

    PubMed

    Kim, Jun-Beom; Lee, Byeong-Rok; Kim, Sung-Hyuk; Park, Jong-Myeong; Park, Young-Bae

    2015-11-01

    In this work, intermetallic compound (IMC) growth behavior in Au stud/Sn/Cu pillar bumps was investigated under annealing and current stressing conditions. AuSn2 and AuSn4 IMCs formed at the interface between the Au studs and Sn after bonding. The AuSn2 phase grew significantly as the stressing time increased, causing micro-voids to form near the (Cu, Au)6Sn5, AuSn2 and AuSn4 IMC interfaces. The interfacial reactions resulting from current stressing took place quicker than observed for pure annealing. The apparent activation energies for the growth of the AuSn2 phase during annealing and current stressing were 0.52 eV and 0.47 eV, respectively, which may be closely related to the acceleration of the interfacial reaction by electron wind forces during current stressing.

  9. Nonuniqueness and multi-bump solutions in parabolic problems with the p-Laplacian

    NASA Astrophysics Data System (ADS)

    Benedikt, Jiří; Girg, Petr; Kotrla, Lukáš; Takáč, Peter

    2016-01-01

    The validity of the weak and strong comparison principles for degenerate parabolic partial differential equations with the p-Laplace operator Δp is investigated for p > 2. This problem is reduced to the comparison of the trivial solution (≡0, by hypothesis) with a nontrivial nonnegative solution u (x , t). The problem is closely related also to the question of uniqueness of a nonnegative solution via the weak comparison principle. In this article, realistic counterexamples to the uniqueness of a nonnegative solution, the weak comparison principle, and the strong maximum principle are constructed with a nonsmooth reaction function that satisfies neither a Lipschitz nor an Osgood standard "uniqueness" condition. Nonnegative multi-bump solutions with spatially disconnected compact supports and zero initial data are constructed between sub- and supersolutions that have supports of the same type.

  10. Recent versus Remote: Flashbulb Memory for 9/11 and Self-Selected Events from the Reminiscence Bump

    ERIC Educational Resources Information Center

    Denver, Jenny Y.; Lane, Sean M.; Cherry, Katie E.

    2010-01-01

    In two related studies, we examined flashbulb memories acquired from different points in the lifespan in younger and older adults. When asked to remember flashbulb memories from their lives, older adults were most likely to recall events from the reminiscence bump (Study 1A). In Study 1B, younger and older adults recalled 9/11 and a personal…

  11. The effect of intermetallic compound morphology on Cu diffusion in Sn-Ag and Sn-Pb solder bump on the Ni/Cu Under-bump metallization

    NASA Astrophysics Data System (ADS)

    Jang, Guh-Yaw; Duh, Jenq-Gong

    2005-01-01

    The eutectic Sn-Ag solder alloy is one of the candidates for the Pb-free solder, and Sn-Pb solder alloys are still widely used in today’s electronic packages. In this tudy, the interfacial reaction in the eutectic Sn-Ag and Sn-Pb solder joints was investigated with an assembly of a solder/Ni/Cu/Ti/Si3N4/Si multilayer structures. In the Sn-3.5Ag solder joints reflowed at 260°C, only the (Ni1-x,Cux)3Sn4 intermetallic compound (IMC) formed at the solder/Ni interface. For the Sn-37Pb solder reflowed at 225°C for one to ten cycles, only the (Ni1-x,Cux)3Sn4 IMC formed between the solder and the Ni/Cu under-bump metallization (UBM). Nevertheless, the (Cu1-y,Niy)6Sn5 IMC was observed in joints reflowed at 245°C after five cycles and at 265°C after three cycles. With the aid of microstructure evolution, quantitative analysis, and elemental distribution between the solder and Ni/Cu UBM, it was revealed that Cu content in the solder near the solder/IMC interface played an important role in the formation of the (Cu1-y,Niy)6Sn5 IMC. In addition, the diffusion behavior of Cu in eutectic Sn-Ag and Sn-Pb solders with the Ni/Cu UBM were probed and discussed. The atomic flux of Cu diffused through Ni was evaluated by detailed quantitative analysis in an electron probe microanalyzer (EPMA). During reflow, the atomic flux of Cu was on the order of 1016-1017 atoms/cm2sec in both the eutectic Sn-Ag and Sn-Pb systems.

  12. Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

    DOE PAGES

    Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.; ...

    2015-01-27

    We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The methodmore » consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.« less

  13. Iron Opacity Bump Changes the Stability and Structure of Accretion Disks in Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Jiang, Yan-Fei; Davis, Shane W.; Stone, James M.

    2016-08-01

    Accretion disks around supermassive black holes have regions where the Rosseland mean opacity can be larger than the electron scattering opacity due to the large number of bound-bound transitions in iron. We study the effects of this iron opacity “bump” on the thermal stability and vertical structure of radiation-pressure-dominated accretion disks, utilizing three-dimensional radiation magnetohydrodynamic (MHD) simulations in the local shearing box approximation. The simulations self-consistently calculate the heating due to MHD turbulence caused by magneto-rotational instability and radiative cooling by using the radiative transfer module based on a variable Eddington tensor in Athena. For a 5 × 108 solar mass black hole with ˜3% of the Eddington luminosity, a model including the iron opacity bump maintains its structure for more than 10 thermal times without showing significant signs of thermal runaway. In contrast, if only electron scattering and free-free opacity are included as in the standard thin disk model, the disk collapses on the thermal timescale. The difference is caused by a combination of (1) an anti-correlation between the total optical depth and the midplane pressure, and (2) enhanced vertical advective energy transport. These results suggest that the iron opacity bump may have a strong impact on the stability and structure of active galactic nucleus (AGN) accretion disks, and may contribute to a dependence of AGN properties on metallicity. Since this opacity is relevant primarily in UV emitting regions of the flow, it may help to explain discrepancies between observation and theory that are unique to AGNs.

  14. Cross-validation and Peeling Strategies for Survival Bump Hunting using Recursive Peeling Methods

    PubMed Central

    Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

    2015-01-01

    We introduce a framework to build a survival/risk bump hunting model with a censored time-to-event response. Our Survival Bump Hunting (SBH) method is based on a recursive peeling procedure that uses a specific survival peeling criterion derived from non/semi-parametric statistics such as the hazards-ratio, the log-rank test or the Nelson--Aalen estimator. To optimize the tuning parameter of the model and validate it, we introduce an objective function based on survival or prediction-error statistics, such as the log-rank test and the concordance error rate. We also describe two alternative cross-validation techniques adapted to the joint task of decision-rule making by recursive peeling and survival estimation. Numerical analyses show the importance of replicated cross-validation and the differences between criteria and techniques in both low and high-dimensional settings. Although several non-parametric survival models exist, none addresses the problem of directly identifying local extrema. We show how SBH efficiently estimates extreme survival/risk subgroups unlike other models. This provides an insight into the behavior of commonly used models and suggests alternatives to be adopted in practice. Finally, our SBH framework was applied to a clinical dataset. In it, we identified subsets of patients characterized by clinical and demographic covariates with a distinct extreme survival outcome, for which tailored medical interventions could be made. An R package PRIMsrc (Patient Rule Induction Method in Survival, Regression and Classification settings) is available on CRAN (Comprehensive R Archive Network) and GitHub. PMID:27034730

  15. Bump evolution driven by the x-ray ablation Richtmyer-Meshkov effect in plastic inertial confinement fusion Ablators

    NASA Astrophysics Data System (ADS)

    Loomis, Eric; Braun, Dave; Batha, Steven H.; Landen, Otto L.

    2013-11-01

    Growth of hydrodynamic instabilities at the interfaces of inertial confinement fusion capsules (ICF) due to ablator and fuel non-uniformities are a primary concern for the ICF program. Recently, observed jetting and parasitic mix into the fuel were attributed to isolated defects on the outer surface of the capsule. Strategies for mitigation of these defects exist, however, they require reduced uncertainties in Equation of State (EOS) models prior to invoking them. In light of this, we have begun a campaign to measure the growth of isolated defects (bumps) due to x-ray ablation Richtmyer-Meshkov in plastic ablators to validate these models. Experiments used hohlraums with radiation temperatures near 70 eV driven by 15 beams from the Omega laser (Laboratory for Laser Energetics, University of Rochester, NY), which sent a ˜1.25Mbar shock into a planar CH target placed over one laser entrance hole. Targets consisted of 2-D arrays of quasi-gaussian bumps (10 microns tall, 34 microns FWHM) deposited on the surface facing into the hohlraum. On-axis radiography with a saran (Cl Heα - 2.76keV) backlighter was used to measure bump evolution prior to shock breakout. Shock speed measurements were also performed to determine target conditions. Simulations using the LEOS 5310 and SESAME 7592 models required the simulated laser power be turned down to 80 and 88%, respectively to match observed shock speeds. Both LEOS 5310 and SESAME 7592 simulations agreed with measured bump areal densities out to 6 ns where ablative RM oscillations were observed in previous laser-driven experiments, but did not occur in the x-ray driven case. The QEOS model, conversely, over predicted shock speeds and under predicted areal density in the bump.

  16. Precision powder feeder

    DOEpatents

    Schlienger, M. Eric; Schmale, David T.; Oliver, Michael S.

    2001-07-10

    A new class of precision powder feeders is disclosed. These feeders provide a precision flow of a wide range of powdered materials, while remaining robust against jamming or damage. These feeders can be precisely controlled by feedback mechanisms.

  17. NEOS Data and the Origin of the 5 MeV Bump in the Reactor Antineutrino Spectrum

    NASA Astrophysics Data System (ADS)

    Huber, Patrick

    2017-01-01

    We perform a combined analysis of recent NEOS and Daya Bay data on the reactor antineutrino spectrum. This analysis includes approximately 1.5 million antineutrino events, which is the largest neutrino event sample analyzed to date. We use a double ratio which cancels flux model dependence and related uncertainties as well as the effects of the detector response model. We find at 3-4 standard deviation significance level, that plutonium-239 and plutonium-241 are disfavored as the single source for the so-called 5 MeV bump. This analysis method has general applicability and, in particular, with higher statistics data sets, will be able to shed significant light on the issue of the bump. With some caveats, this should also allow us to improve the sensitivity for sterile neutrino searches in NEOS.

  18. Using a shock control bump to improve the performance of an axial compressor blade section

    NASA Astrophysics Data System (ADS)

    Mazaheri, K.; Khatibirad, S.

    2017-03-01

    Here, we use numerical analysis to study the effects of a shock control bump (SCB) on the performance of a transonic axial compressor blade section and to optimize its shape and location to improve the compressor performance. A section of the NASA rotor 67 blade is used for this study. Two Bézier curves, each consisting of seven control points, are used to model the suction and pressure surfaces of the blade section. The SCB is modeled with the Hicks-Henne function and, using five design parameters, is added to the suction side. The total pressure loss through a cascade of blade sections is selected as the cost function. A continuous adjoint optimization method is used along with a RANS solver to find a new blade section shape. A grid independence study is performed, and all optimization and flow solver algorithms are validated. Two single-point optimizations are performed in the design condition and in an off-design condition. It is shown that both optimized shapes have overall better performance for both on-design and off-design conditions. An analysis is given regarding how the SCB has changed the wave structure between blade sections resulting in a more favorable flow pattern.

  19. A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.

    PubMed

    Castellanos-Gonzalez, Alejandro; Sparks, Hayley; Nava, Samantha; Huang, Wenlin; Zhang, Zhongsheng; Rivas, Kasey; Hulverson, Matthew A; Barrett, Lynn K; Ojo, Kayode K; Fan, Erkang; Van Voorhis, Wesley C; White, Arthur Clinton

    2016-12-15

    Cryptosporidium is recognized as one of the main causes of childhood diarrhea worldwide. However, the current treatment for cryptosporidiosis is suboptimal. Calcium flux is essential for entry in apicomplexan parasites. Calcium-dependent protein kinases (CDPKs) are distinct from protein kinases of mammals, and the CDPK1 of the apicomplexan Cryptosporidium lack side chains that typically block a hydrophobic pocket in protein kinases. We exploited this to develop bumped kinase inhibitors (BKIs) that selectively target CDPK1. We have shown that several BKIs of Cryptosporidium CDPK1 potently reduce enzymatic activity and decrease parasite numbers when tested in vitro. In the present work, we studied the anticryptosporidial activity of BKI-1517, a novel BKI. The half maximal effective concentration for Cryptosporidium parvum in HCT-8 cells was determined to be approximately 50 nM. Silencing experiments of CDPK1 suggest that BKI-1517 acts on CDPK1 as its primary target. In a mouse model of chronic infection, 5 of 6 SCID/beige mice (83.3%) were cured after treatment with a single daily dose of 120 mg/kg BKI-1517. No side effects were observed. These data support advancing BKI-1517 as a lead compound for drug development for cryptosporidiosis.

  20. Does recall of a past music event invoke a reminiscence bump in young adults?

    PubMed

    Schubert, Emery

    2016-08-01

    Many studies of the reminiscence bump (RB) in music invoke memories from different autobiographical times by using stimulus specific prompts (SSPs). This study investigated the utility of a non-SSP paradigm to determine whether the RB would emerge when participants were asked to recall a single memorable musical event from "a time long ago". The presence of a RB in response to music has not been obtained in such a manner for younger participants. Eighty-eight 20-22 year olds reported music episodes that peaked when their autobiographical age was 13-14 years. Self-selected stimuli included a range of musical styles, including classical and non-Western pop forms, such as J-pop and K-pop, as well as generational pop music, such as the Beatles. However, most participants reported pop/rock music that was contemporaneous with encoding age, providing support for the utility of published SSP paradigms using pop music. Implications for and limitations of SSP paradigms are discussed. Participants were also asked to relate the selected musical piece to current musical tastes. Most participants liked the music that they selected, with many continuing to like the music, but most also reported a general broadening of their taste, consistent with developmental literature on open-earedness.

  1. An analysis of reservoir storage contents for the proposed enlargement of Bumping Lake in Washington

    USGS Publications Warehouse

    Bartells, John H.

    1981-01-01

    Monthend contents of the proposed Bumping Lake enlargement in Washington were determined for the period 1917-73 by using the historic streamflow record as a basis for inflow to the reservoir and imposing certain operational requirements on reservoir releases. The operational requirements used were those set forth in the Environmental Statement that was prepared for the project by the U.S. Water and Power Resources Service (formerly the U.S. Bureau of Reclamation). The computations show that after starting with an empty reservoir on October 1, 1917, the 458,000 acre-feet capacity of the enlarged lake could be nearly full (384,000 acre-feet) on November 30, 1925, which is the starting scenario given in the Environmental Statement. From 1925 to 1973 the computations compare favorably with those shown in the Environmental Statement, with minor differences due to releases of fish enhancement water. In all cases studied, all fishwater requirements and all existing irrigation requirements were met, and generally from 30,000 to 90,000 acre-feet of extra irrigation water could be available in most years. (USGS)

  2. A Tale of Two Mysteries in Interstellar Astrophysics: The 2175 Å Extinction Bump and Diffuse Interstellar Bands

    NASA Astrophysics Data System (ADS)

    Xiang, F. Y.; Li, Aigen; Zhong, J. X.

    2011-06-01

    The diffuse interstellar bands (DIBs) are ubiquitous absorption spectral features arising from the tenuous material in the space between stars—the interstellar medium (ISM). Since their first detection nearly nine decades ago, over 400 DIBs have been observed in the visible and near-infrared wavelength range in both the Milky Way and external galaxies, both nearby and distant. However, the identity of the species responsible for these bands remains as one of the most enigmatic mysteries in astrophysics. An equally mysterious interstellar spectral signature is the 2175 Å extinction bump, the strongest absorption feature observed in the ISM. Its carrier also remains unclear since its first detection 46 years ago. Polycyclic aromatic hydrocarbon (PAH) molecules have long been proposed as a candidate for DIBs as their electronic transitions occur in the wavelength range where DIBs are often found. In recent years, the 2175 Å extinction bump is also often attributed to the π-π* transition in PAHs. If PAHs are indeed responsible for both the 2175 Å extinction feature and DIBs, their strengths may correlate. We perform an extensive literature search for lines of sight for which both the 2175 Å extinction feature and DIBs have been measured. Unfortunately, we found no correlation between the strength of the 2175 Å feature and the equivalent widths of the strongest DIBs. A possible explanation might be that DIBs are produced by small free gas-phase PAH molecules and ions, while the 2175 Å bump is mainly from large PAHs or PAH clusters in condensed phase so that there is no tight correlation between DIBs and the 2175 Å bump.

  3. Blue supergiant model for ultra-long gamma-ray burst with superluminous-supernova-like bump

    SciTech Connect

    Nakauchi, Daisuke; Nakamura, Takashi; Kashiyama, Kazumi; Suwa, Yudai

    2013-11-20

    Long gamma-ray bursts (LGRBs) have a typical duration of ∼30 s, and some of them are associated with hypernovae, such as Type Ic SN 1998bw. Wolf-Rayet stars are the most plausible LGRB progenitors, since the free fall time of the envelope is consistent with the duration, and the natural outcome of the progenitor is a Type Ic SN. While a new population of ultra-long GRBs (ULGRBs), GRB 111209A, GRB 101225A, and GRB 121027A, has a duration of ∼10{sup 4} s, two of them are accompanied by superluminous-supernova-like (SLSN-like) bumps, which are ≲ 10 times brighter than typical hypernovae. Wolf-Rayet progenitors cannot explain ULGRBs because of durations that are too long and SN-like bumps that are too bright. A blue supergiant (BSG) progenitor model, however, can explain the duration of ULGRBs. Moreover, SLSN-like bumps can be attributed to the so-called cocoon fireball photospheric emissions (CFPEs). Since a large cocoon is inevitably produced during the relativistic jet piercing though the BSG envelope, this component can be smoking gun evidence of the BSG model for ULGRBs. In this paper, we examine u-, g-, r-, i-, and J-band light curves of three ULGRBs and demonstrate that they can be fitted quite well by our BSG model with the appropriate choices of the jet opening angle and the number density of the ambient gas. In addition, we predict that for 121027A, SLSN-like bump could have been observed for ∼20-80 days after the burst. We also propose that some SLSNe might be CFPEs of off-axis ULGRBs without visible prompt emissions.

  4. A TALE OF TWO MYSTERIES IN INTERSTELLAR ASTROPHYSICS: THE 2175 A EXTINCTION BUMP AND DIFFUSE INTERSTELLAR BANDS

    SciTech Connect

    Xiang, F. Y.; Zhong, J. X.; Li Aigen E-mail: lia@missouri.edu

    2011-06-01

    The diffuse interstellar bands (DIBs) are ubiquitous absorption spectral features arising from the tenuous material in the space between stars-the interstellar medium (ISM). Since their first detection nearly nine decades ago, over 400 DIBs have been observed in the visible and near-infrared wavelength range in both the Milky Way and external galaxies, both nearby and distant. However, the identity of the species responsible for these bands remains as one of the most enigmatic mysteries in astrophysics. An equally mysterious interstellar spectral signature is the 2175 A extinction bump, the strongest absorption feature observed in the ISM. Its carrier also remains unclear since its first detection 46 years ago. Polycyclic aromatic hydrocarbon (PAH) molecules have long been proposed as a candidate for DIBs as their electronic transitions occur in the wavelength range where DIBs are often found. In recent years, the 2175 A extinction bump is also often attributed to the {pi}-{pi}* transition in PAHs. If PAHs are indeed responsible for both the 2175 A extinction feature and DIBs, their strengths may correlate. We perform an extensive literature search for lines of sight for which both the 2175 A extinction feature and DIBs have been measured. Unfortunately, we found no correlation between the strength of the 2175 A feature and the equivalent widths of the strongest DIBs. A possible explanation might be that DIBs are produced by small free gas-phase PAH molecules and ions, while the 2175 A bump is mainly from large PAHs or PAH clusters in condensed phase so that there is no tight correlation between DIBs and the 2175 A bump.

  5. Improving Touschek lifetime in ultralow-emittance lattices through systematic application of successive closed vertical dispersion bumps

    NASA Astrophysics Data System (ADS)

    Breunlin, J.; Leemann, S. C.; Andersson, Å.

    2016-06-01

    In present ultralow-emittance storage ring designs the emittance coupling required for the production of vertically diffraction-limited synchrotron radiation in the hard x-ray regime is achieved and in many cases surpassed by a correction of the orbit and the linear optics alone. However, operating with a vertical emittance lower than required is disadvantageous, since it decreases Touschek lifetime and reduces brightness due to the transverse emittance increase from intrabeam scattering. In this paper we present a scheme consisting of closed vertical dispersion bumps successively excited in each arc of the storage ring by skew quadrupoles that couple horizontal dispersion into the vertical plane to a desired level and thereby raise the vertical emittance in a controlled fashion. A systematic approach to vertical dispersion bumps has been developed that suppresses dispersion and betatron coupling in the straight sections in order to maintain a small projected emittance for insertion devices. In this way, beam lifetime can be significantly increased without negatively impacting insertion device source properties and hence brightness. Using simulation results for the MAX IV 3 GeV storage ring including magnet and alignment imperfections we demonstrate that Touschek lifetime can be increased by more than a factor 2 by adjusting the vertical emittance from 1.3 pm rad (after orbit correction) to 8 pm rad (after application of dispersion bumps) using two to three independent skew quadrupole families all the while ensuring deviations from design optics are restrained to a minimum.

  6. Parasitic slow extraction of extremely weak beam from a high-intensity proton rapid cycling synchrotron

    NASA Astrophysics Data System (ADS)

    Zou, Ye; Tang, Jingyu; Yang, Zheng; Jing, Hantao

    2014-02-01

    This paper proposes a novel method to extract extremely weak beam from a high-intensity proton rapid cycling synchrotron (RCS) in the parasitic mode, while maintaining the normal fast extraction. The usual slow extraction method from a synchrotron by employing third-order resonance cannot be applied in a high-intensity RCS due to a very short flat-top at the extraction energy and the strict control on beam loss. The proposed parasitic slow extraction method moves the beam to scrape a scattering foil prior to the fast beam extraction by employing either a local orbit bump or momentum deviation or their combination, so that the halo part of the beam will be scattered. A part of the scattered particles will be extracted from the RCS and guided to the experimental area. The slow extraction process can last about a few milliseconds before the beam is extracted by the fast extraction system. The method has been applied to the RCS of China Spallation Neutron Source. With 1.6 GeV in the extraction energy, 62.5 μA in the average current and 25 Hz in the repetition rate for the RCS, the proton intensity by the slow extraction method can be up to 2×104 protons per cycle or 5×105 protons per second. The extracted beam has also a good time structure of approximately uniform in a spill which is required for many applications such as detector tests. Detailed studies including the scattering effect in the foil, the local orbit bump by the bump magnets and dispersive orbit bump by modifying the RF pattern, the multi-particle simulations by ORBIT and TURTLE codes, and some technical features for the extraction magnets are presented.

  7. Control of flow separation on a contour bump by jets in a Mach 1.9 free-stream: An experimental study

    NASA Astrophysics Data System (ADS)

    Lo, Kin Hing; Zare-Behtash, Hossein; Kontis, Konstantinos

    2016-09-01

    Flow separation control over a three-dimensional contour bump using jet in a Mach 1.9 supersonic free-stream has been experimentally investigated using a transonic/supersonic wind tunnel. Jet total pressure in the range of 0-4 bar was blowing at the valley of the contour bump. Schlieren photography, surface oil flow visualisation and particle image velocimetry measurements were employed for flow visualisation and diagnostics. Experimental results show that blowing jet at the valley of the contour bump can hinder the formation and distort the spanwise vortices. The blowing jet can also reduce the extent of flow separation appears downstream of the bump crest. It was observed that this approach of flow control is more effective when high jet total pressure is employed. It is believed that a pressure gradient is generated as a result of the interaction between the flow downstream of the bump crest and the jet induced shock leads to the downwards flow motion around the bump valley.

  8. Coal mine bumps as related to geologic features in the northern part of the Sunnyside District, Carbon County, Utah

    USGS Publications Warehouse

    Osterwald, Frank W.; Dunrud, C. Richard; Collins, Donley S.

    1993-01-01

    Coal mine bumps, which are violent, spontaneous, and often catastrophic disruptions of coal and rock, were common in the Sunnyside coal mining district, Utah, before the introduction of protective-engineering methods, modern room-and-pillar retreat mining with continuous mining machines, and particularly modern longwall mining. The coal at Sunnyside, when stressed during mining, fails continuously with many popping, snapping, and banging noises. Although most of the bumps are beneficial because they make mining easier, many of the large ones are dangerous and in the past caused injuries and fatalities, particularly with room- and-pillar mining methods used in the early mining operations. Geologic mapping of underground mine openings revealed many types of deformational features, some pre-mine and some post-mine in age. Stresses resulting from mining are concentrated near the mine openings; if openings are driven at large angles to small pre-mine deformational features, particularly shatter zones in coal, abnormal stress buildups may occur and violent bumps may result. Other geologic features, such as ripple marks, oriented sand grains, intertongued rock contacts, trace fossils, and load casts, also influence the occurrence of bumps by impeding slip of coal and rocks along bedding planes. The stress field in the coal also varies markedly because of the rough ridge and canyon topography. These features may allow excessively large stress components to accumulate. At many places, the stresses that contribute to deformation and failures of mine openings are oriented horizontally. The stratigraphy of the rocks immediately above and below the mined coal bed strongly influences the deformation of the mine openings in response to stress accumulations. Triaxial compressive testing of coal from the Sunnyside No.1 and No.3 Mines indicates that the strength of the coal increases several times as the confining (lateral) stress is increased. Strengths of cores cut from single

  9. Orbit Distortions and Bumps in the PEP-II LER Ring

    SciTech Connect

    Decker, Franz-Josef

    2002-08-13

    The PEP-II B-factory has already achieved twice the design daily-integrated luminosity. This is even more remarkable when looking at the beam orbits, especially in the low energy ring (LER). Orbit oscillations with an amplitude of 7 mm have grown over the years. Four attempts to steer them down resulted in a much lower luminosity and were therefore backed out. Finally, in August of 2001, the main part of the ring (5/6) could be steered flat, while keeping the sixth where the interaction region (IR) is located untouched. This resulted in a lower global dispersion and more luminosity. Since then the orbit is flat to 0.5 mm (slowly increasing to 2-3 mm), except in the IR where about four oscillations on each side of the interaction point reach peaks of 7-9 mm. This area is highly coupled by skew quadrupoles, which are compensating the effects of the BaBar solenoid field. The region also has strong sextupoles. In order to attack the remaining orbit excursions one at a time, an orbit bump program has been extended to handle coupled regions, by closing the oscillations in the other plane. Due to the big oscillations the beam is often close to the walls generating beam loss and reducing the lifetime. An interesting observation occurred a few times when the high-current LER beam was pulled away from the wall. The size of the LER or its tune appeared to have changed since the colliding beam started to blow up the high energy beam implying a decrease in the size of the LER beam. This was in a linear region so the effect has to come from unknown field errors, or more likely it is an effect of the high-current beam with its surrounding either electron cloud or wakefields.

  10. Critical Steady Surface Waves of Idea Fluid over a Bump with Surface Tension

    NASA Astrophysics Data System (ADS)

    Choi, Jeongwhan; Lee, Sangwon; Kim, Joonkyoung; Whang, Sungim

    2016-11-01

    The paper deals with steady forced surface waves propagating on a two-dimensional incompressible and inviscid fluid with a small bump placed on a rigid flat bottom. If the surface tension coefficient T on the free surface is not zero and the wave is moving with a constant speed C, the wave motion is determined by two non-dimensional constants, F = √ gh and I = T / (ρgh 2) , where g is the gravity constant and h is the height of the fluid at infinity. It has been known that F = 1 and t = 1/3 are the critical values of F and t, respectively. In the critical case F = 1 + λ 1 ɛ 2 and t = 1/3 + t1 ɛ with ɛ > 0 a small parameter, a time-dependent forced Kawahara (F-Kawahara)equation is derived to model the wave propagation on the free surface and the steady F-Kawahara equation is studied both theoretically and merically. It is shown that the steady F-Kawahara equation has many different kinds of one and multi-hump solutions when t1 and λ 1 vary. In particular, for a fixed t 1, there is a λ 0 < 0 such that if λ 1 < λ 0 , two one-hump steady solutions can be obtained, one with small amplitude and the other with large amplitude. By using the unsteady F-Kawahara equation, it appears that the small one-hump solution is stable while the large one is nstable. In addition, two-hump solutions are unstable.

  11. The Bump Hunting by the Decision Tree with the Genetic Algorithm

    NASA Astrophysics Data System (ADS)

    Hirose, Hideo

    In difficult classification problems of the z-dimensional points into two groups giving 0-1 responses due to the messy data structure, it is more favorable to search for the denser regions for the response 1 points than to find the boundaries to separate the two groups. For such problems which can often be seen in customer databases, we have developed a bump hunting method using probabilistic and statistical methods as shown in the previous study. By specifying a pureness rate in advance, a maximum capture rate will be obtained. In finding the maximum capture rate, we have used the decision tree method combined with the genetic algorithm. Then, a trade-off curve between the pureness rate and the capture rate can be constructed. However, such a trade-off curve could be optimistic if the training data set alone is used. Therefore, we should be careful in assessing the accuracy of the tradeoff curve. Using the accuracy evaluation procedures such as the cross validation or the bootstrapped hold-out method combined with the training and test data sets, we have shown that the actually applicable trade-off curve can be obtained. We have also shown that an attainable upper bound trade-off curve can be estimated by using the extreme-value statistics because the genetic algorithm provides many local maxima of the capture rates with different initial values. We have constructed the three kinds of trade-off curves; the first is the curve obtained by using the training data; the second is the return capture rate curve obtained by using the extreme-value statistics; the last is the curve obtained by using the test data. These three are indispensable like the Trinity to comprehend the whole figure of the trade-off curve between the pureness rate and the capture rate. This paper deals with the behavior of the trade-off curve from a statistical viewpoint.

  12. Precise Countersinking Tool

    NASA Technical Reports Server (NTRS)

    Jenkins, Eric S.; Smith, William N.

    1992-01-01

    Tool countersinks holes precisely with only portable drill; does not require costly machine tool. Replaceable pilot stub aligns axis of tool with centerline of hole. Ensures precise cut even with imprecise drill. Designed for relatively low cutting speeds.

  13. Precision agricultural systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision agriculture is a new farming practice that has been developing since late 1980s. It has been variously referred to as precision farming, prescription farming, site-specific crop management, to name but a few. There are numerous definitions for precision agriculture, but the central concept...

  14. Bumps on the managed care road: the search for an alternative model to reduce collisions between HMOs, physicians, and patients.

    PubMed

    Reece, R L

    2000-01-01

    Managed care is experiencing political, litigious, and financial bumps on the road. There are various reasons for this bumpy ride: out-of-control costs, prescription drug expense, negative media reports, public revolt at denials of care or limited access to specialists, bad physician relations, patients' rights legislation, dropping health maintenance organization (HMO) stock prices, the ripple effect of the Harvard Pilgrim bankruptcy, and threat of massive litigation against HMOs. Two reasons not often mentioned, but explored in this article, are the orthodox managed care's flawed market model and lack of enough understanding of physician culture and emerging consumer trends to effectively address these two key constituencies.

  15. Thermal cycling reliability of Cu/SnAg double-bump flip chip assemblies for 100 μm pitch applications

    NASA Astrophysics Data System (ADS)

    Son, Ho-Young; Kim, Ilho; Lee, Soon-Bok; Jung, Gi-Jo; Park, Byung-Jin; Paik, Kyung-Wook

    2009-01-01

    A thick Cu column based double-bump flip chip structure is one of the promising alternatives for fine pitch flip chip applications. In this study, the thermal cycling (T/C) reliability of Cu/SnAg double-bump flip chip assemblies was investigated, and the failure mechanism was analyzed through the correlation of T/C test and the finite element analysis (FEA) results. After 1000 thermal cycles, T/C failures occurred at some Cu/SnAg bumps located at the edge and corner of chips. Scanning acoustic microscope analysis and scanning electron microscope observations indicated that the failure site was the Cu column/Si chip interface. It was identified by a FEA where the maximum stress concentration was located during T/C. During T/C, the Al pad between the Si chip and a Cu column bump was displaced due to thermomechanical stress. Based on the low cycle fatigue model, the accumulation of equivalent plastic strain resulted in thermal fatigue deformation of the Cu column bumps and ultimately reduced the thermal cycling lifetime. The maximum equivalent plastic strains of some bumps at the chip edge increased with an increased number of thermal cycles. However, equivalent plastic strains of the inner bumps did not increase regardless of the number of thermal cycles. In addition, the z-directional normal plastic strain ɛ22 was determined to be compressive and was a dominant component causing the plastic deformation of Cu/SnAg double bumps. As the number of thermal cycles increased, normal plastic strains in the perpendicular direction to the Si chip and shear strains were accumulated on the Cu column bumps at the chip edge at low temperature region. Thus it was found that the Al pad at the Si chip/Cu column interface underwent thermal fatigue deformation by compressive normal strain and the contact loss by displacement failure of the Al pad, the main T/C failure mode of the Cu/SnAg flip chip assembly, then occurred at the Si chip/Cu column interface shear strain deformation

  16. Precision performance lamp technology

    NASA Astrophysics Data System (ADS)

    Bell, Dean A.; Kiesa, James E.; Dean, Raymond A.

    1997-09-01

    A principal function of a lamp is to produce light output with designated spectra, intensity, and/or geometric radiation patterns. The function of a precision performance lamp is to go beyond these parameters and into the precision repeatability of performance. All lamps are not equal. There are a variety of incandescent lamps, from the vacuum incandescent indictor lamp to the precision lamp of a blood analyzer. In the past the definition of a precision lamp was described in terms of wattage, light center length (LCL), filament position, and/or spot alignment. This paper presents a new view of precision lamps through the discussion of a new segment of lamp design, which we term precision performance lamps. The definition of precision performance lamps will include (must include) the factors of a precision lamp. But what makes a precision lamp a precision performance lamp is the manner in which the design factors of amperage, mscp (mean spherical candlepower), efficacy (lumens/watt), life, not considered individually but rather considered collectively. There is a statistical bias in a precision performance lamp for each of these factors; taken individually and as a whole. When properly considered the results can be dramatic to the system design engineer, system production manage and the system end-user. It can be shown that for the lamp user, the use of precision performance lamps can translate to: (1) ease of system design, (2) simplification of electronics, (3) superior signal to noise ratios, (4) higher manufacturing yields, (5) lower system costs, (6) better product performance. The factors mentioned above are described along with their interdependent relationships. It is statistically shown how the benefits listed above are achievable. Examples are provided to illustrate how proper attention to precision performance lamp characteristics actually aid in system product design and manufacturing to build and market more, market acceptable product products in the

  17. [Precision and personalized medicine].

    PubMed

    Sipka, Sándor

    2016-10-01

    The author describes the concept of "personalized medicine" and the newly introduced "precision medicine". "Precision medicine" applies the terms of "phenotype", "endotype" and "biomarker" in order to characterize more precisely the various diseases. Using "biomarkers" the homogeneous type of a disease (a "phenotype") can be divided into subgroups called "endotypes" requiring different forms of treatment and financing. The good results of "precision medicine" have become especially apparent in relation with allergic and autoimmune diseases. The application of this new way of thinking is going to be necessary in Hungary, too, in the near future for participants, controllers and financing boards of healthcare. Orv. Hetil., 2016, 157(44), 1739-1741.

  18. Precision positioning device

    DOEpatents

    McInroy, John E.

    2005-01-18

    A precision positioning device is provided. The precision positioning device comprises a precision measuring/vibration isolation mechanism. A first plate is provided with the precision measuring mean secured to the first plate. A second plate is secured to the first plate. A third plate is secured to the second plate with the first plate being positioned between the second plate and the third plate. A fourth plate is secured to the third plate with the second plate being positioned between the third plate and the fourth plate. An adjusting mechanism for adjusting the position of the first plate, the second plate, the third plate, and the fourth plate relative to each other.

  19. Dynamics and afterglow light curves of gamma-ray burst blast waves encountering a density bump or void

    SciTech Connect

    Uhm, Z. Lucas; Zhang, Bing E-mail: zhang@physics.unlv.edu

    2014-07-01

    We investigate the dynamics and afterglow light curves of gamma-ray burst blast waves that encounter various density structures (such as bumps, voids, or steps) in the surrounding ambient medium. We present and explain the characteristic response features that each type of density structure in the medium leaves on the forward shock (FS) and reverse shock (RS) dynamics for blast waves with either a long-lived or short-lived RS. We show that when the ambient medium density drops, the blast waves exhibit in some cases a period of an actual acceleration (even during their deceleration stage) due to adiabatic cooling of blast waves. Comparing numerical examples that have different shapes of bumps or voids, we propose a number of consistency tests that must be satisfied by correct modeling of blast waves. Our model results successfully pass these tests. Employing a Lagrangian description of blast waves, we perform a sophisticated calculation of afterglow emission. We show that as a response to density structures in the ambient medium, the RS light curves produce more significant variations than the FS light curves. Some observed features (such as rebrightenings, dips, or slow wiggles) can be more easily explained within the RS model. We also discuss the origin of these different features imprinted on the FS and RS light curves.

  20. The reminiscence bump without memories: The distribution of imagined word-cued and important autobiographical memories in a hypothetical 70-year-old.

    PubMed

    Koppel, Jonathan; Berntsen, Dorthe

    2016-08-01

    The reminiscence bump is the disproportionate number of autobiographical memories dating from adolescence and early adulthood. It has often been ascribed to a consolidation of the mature self in the period covered by the bump. Here we stripped away factors relating to the characteristics of autobiographical memories per se, most notably factors that aid in their encoding or retention, by asking students to generate imagined word-cued and imagined 'most important' autobiographical memories of a hypothetical, prototypical 70-year-old of their own culture and gender. We compared the distribution of these fictional memories with the distributions of actual word-cued and most important autobiographical memories in a sample of 61-70-year-olds. We found a striking similarity between the temporal distributions of the imagined memories and the actual memories. These results suggest that the reminiscence bump is largely driven by constructive, schematic factors at retrieval, thereby challenging most existing theoretical accounts.

  1. Precision enhancement of pavement roughness localization with connected vehicles

    NASA Astrophysics Data System (ADS)

    Bridgelall, R.; Huang, Y.; Zhang, Z.; Deng, F.

    2016-02-01

    Transportation agencies rely on the accurate localization and reporting of roadway anomalies that could pose serious hazards to the traveling public. However, the cost and technical limitations of present methods prevent their scaling to all roadways. Connected vehicles with on-board accelerometers and conventional geospatial position receivers offer an attractive alternative because of their potential to monitor all roadways in real-time. The conventional global positioning system is ubiquitous and essentially free to use but it produces impractically large position errors. This study evaluated the improvement in precision achievable by augmenting the conventional geo-fence system with a standard speed bump or an existing anomaly at a pre-determined position to establish a reference inertial marker. The speed sensor subsequently generates position tags for the remaining inertial samples by computing their path distances relative to the reference position. The error model and a case study using smartphones to emulate connected vehicles revealed that the precision in localization improves from tens of metres to sub-centimetre levels, and the accuracy of measuring localized roughness more than doubles. The research results demonstrate that transportation agencies will benefit from using the connected vehicle method to achieve precision and accuracy levels that are comparable to existing laser-based inertial profilers.

  2. Void Evolution in Sub-100-Micron Sn-Ag Solder Bumps during Multi-reflow and Aging and its Effects on Bonding Reliability

    NASA Astrophysics Data System (ADS)

    Lin, Xiaoqin; Luo, Le

    2008-03-01

    The evolution of voids in the interfacial region of electroplated Sn-3.0Ag solder bumps on electroplated Cu and its effects on bonding reliability were studied. Results show that volume shrinkage resulted in void formation during multi-reflow, while the Kirkendall effect led to void formation during aging. A thick η-phase and voids at the boundaries among Cu6Sn5 grains promoted the void growth in the ɛ-phase. Though the formation of voids had a trivial weakening effect on the shear strength of the solder joints, the voids were a threat to the bonding reliability of solder bumps.

  3. Precision antenna reflector structures

    NASA Technical Reports Server (NTRS)

    Hedgepeth, J. M.

    1985-01-01

    The assembly of the Large Precise Reflector Infrared Telescope is detailed. Also given are the specifications for the Aft Cargo Carrier and the Large Precision Reflector structure. Packaging concepts and options, stowage depth and support truss geometry are also considered. An example of a construction scenario is given.

  4. Precision Optics Curriculum.

    ERIC Educational Resources Information Center

    Reid, Robert L.; And Others

    This guide outlines the competency-based, two-year precision optics curriculum that the American Precision Optics Manufacturers Association has proposed to fill the void that it suggests will soon exist as many of the master opticians currently employed retire. The model, which closely resembles the old European apprenticeship model, calls for 300…

  5. Precision volume measurement system.

    SciTech Connect

    Fischer, Erin E.; Shugard, Andrew D.

    2004-11-01

    A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.

  6. Precision liquid level sensor

    DOEpatents

    Field, M.E.; Sullivan, W.H.

    A precision liquid level sensor utilizes a balanced bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge.

  7. Optimetrics for Precise Navigation

    NASA Technical Reports Server (NTRS)

    Yang, Guangning; Heckler, Gregory; Gramling, Cheryl

    2017-01-01

    Optimetrics for Precise Navigation will be implemented on existing optical communication links. The ranging and Doppler measurements are conducted over communication data frame and clock. The measurement accuracy is two orders of magnitude better than TDRSS. It also has other advantages of: The high optical carrier frequency enables: (1) Immunity from ionosphere and interplanetary Plasma noise floor, which is a performance limitation for RF tracking; and (2) High antenna gain reduces terminal size and volume, enables high precision tracking in Cubesat, and in deep space smallsat. High Optical Pointing Precision provides: (a) spacecraft orientation, (b) Minimal additional hardware to implement Precise Optimetrics over optical comm link; and (c) Continuous optical carrier phase measurement will enable the system presented here to accept future optical frequency standard with much higher clock accuracy.

  8. Precision Measurement in Biology

    NASA Astrophysics Data System (ADS)

    Quake, Stephen

    Is biology a quantitative science like physics? I will discuss the role of precision measurement in both physics and biology, and argue that in fact both fields can be tied together by the use and consequences of precision measurement. The elementary quanta of biology are twofold: the macromolecule and the cell. Cells are the fundamental unit of life, and macromolecules are the fundamental elements of the cell. I will describe how precision measurements have been used to explore the basic properties of these quanta, and more generally how the quest for higher precision almost inevitably leads to the development of new technologies, which in turn catalyze further scientific discovery. In the 21st century, there are no remaining experimental barriers to biology becoming a truly quantitative and mathematical science.

  9. Precision displacement reference system

    DOEpatents

    Bieg, Lothar F.; Dubois, Robert R.; Strother, Jerry D.

    2000-02-22

    A precision displacement reference system is described, which enables real time accountability over the applied displacement feedback system to precision machine tools, positioning mechanisms, motion devices, and related operations. As independent measurements of tool location is taken by a displacement feedback system, a rotating reference disk compares feedback counts with performed motion. These measurements are compared to characterize and analyze real time mechanical and control performance during operation.

  10. Recent versus remote: flashbulb memory for 9/11 and self-selected events from the reminiscence bump.

    PubMed

    Denver, Jenny Y; Lane, Sean M; Cherry, Katie E

    2010-01-01

    In two related studies, we examined flashbulb memories acquired from different points in the lifespan in younger and older adults. When asked to remember flashbulb memories from their lives, older adults were most likely to recall events from the reminiscence bump (Study 1A). In Study 1B, younger and older adults recalled 9/11 and a personal flashbulb event that occurred between ages 10 and 30. Older adults' memories of a recent event (9/11) were less likely than younger adults' to be classified as flashbulb memories; however, when memories were examined in their entirety, these age-related declines disappeared. Older adults' memories for a remote flashbulb event appeared to be quite similar, if not more detailed than their memories for the recent event, suggesting that remote flashbulb memories are relatively stable over time. Implications of these data for current views of flashbulb memory in late adulthood are discussed.

  11. Precision medicine in cardiology.

    PubMed

    Antman, Elliott M; Loscalzo, Joseph

    2016-10-01

    The cardiovascular research and clinical communities are ideally positioned to address the epidemic of noncommunicable causes of death, as well as advance our understanding of human health and disease, through the development and implementation of precision medicine. New tools will be needed for describing the cardiovascular health status of individuals and populations, including 'omic' data, exposome and social determinants of health, the microbiome, behaviours and motivations, patient-generated data, and the array of data in electronic medical records. Cardiovascular specialists can build on their experience and use precision medicine to facilitate discovery science and improve the efficiency of clinical research, with the goal of providing more precise information to improve the health of individuals and populations. Overcoming the barriers to implementing precision medicine will require addressing a range of technical and sociopolitical issues. Health care under precision medicine will become a more integrated, dynamic system, in which patients are no longer a passive entity on whom measurements are made, but instead are central stakeholders who contribute data and participate actively in shared decision-making. Many traditionally defined diseases have common mechanisms; therefore, elimination of a siloed approach to medicine will ultimately pave the path to the creation of a universal precision medicine environment.

  12. Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

    NASA Astrophysics Data System (ADS)

    Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

    2011-01-01

    The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

  13. Estimating sparse precision matrices

    NASA Astrophysics Data System (ADS)

    Padmanabhan, Nikhil; White, Martin; Zhou, Harrison H.; O'Connell, Ross

    2016-08-01

    We apply a method recently introduced to the statistical literature to directly estimate the precision matrix from an ensemble of samples drawn from a corresponding Gaussian distribution. Motivated by the observation that cosmological precision matrices are often approximately sparse, the method allows one to exploit this sparsity of the precision matrix to more quickly converge to an asymptotic 1/sqrt{N_sim} rate while simultaneously providing an error model for all of the terms. Such an estimate can be used as the starting point for further regularization efforts which can improve upon the 1/sqrt{N_sim} limit above, and incorporating such additional steps is straightforward within this framework. We demonstrate the technique with toy models and with an example motivated by large-scale structure two-point analysis, showing significant improvements in the rate of convergence. For the large-scale structure example, we find errors on the precision matrix which are factors of 5 smaller than for the sample precision matrix for thousands of simulations or, alternatively, convergence to the same error level with more than an order of magnitude fewer simulations.

  14. Precision QCD measurements at HERA

    NASA Astrophysics Data System (ADS)

    Pirumov, Hayk

    2014-11-01

    A review of recent experimental results on perturbative QCD from the HERA experiments H1 and ZEUS is presented. All inclusive deep inelastic cross sections measured by the H1 and ZEUS collaborations in neutral and charged current unpolarised ep scattering are combined. They span six orders of magnitude in negative four-momentum-transfer squared, Q2, and in Bjorken x. This data set is used as the sole input to NLO and NNLO QCD analyses to determine new sets of parton distributions, HERAPDF2.0, with small experimental uncertainties and an estimate of model and parametrisation uncertainties. Also shown are new results on inclusive jet, dijet and trijet differential cross sections measured in neutral current deep inelastic scattering. The precision jet data is used to extract the strong coupling αs at NLO with small experimental errors.

  15. Precision Muonium Spectroscopy

    NASA Astrophysics Data System (ADS)

    Jungmann, Klaus P.

    2016-09-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 µs. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular ground state hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular quantum electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  16. How Physics Got Precise

    SciTech Connect

    Kleppner, Daniel

    2005-01-19

    Although the ancients knew the length of the year to about ten parts per million, it was not until the end of the 19th century that precision measurements came to play a defining role in physics. Eventually such measurements made it possible to replace human-made artifacts for the standards of length and time with natural standards. For a new generation of atomic clocks, time keeping could be so precise that the effects of the local gravitational potentials on the clock rates would be important. This would force us to re-introduce an artifact into the definition of the second - the location of the primary clock. I will describe some of the events in the history of precision measurements that have led us to this pleasing conundrum, and some of the unexpected uses of atomic clocks today.

  17. Precision gap particle separator

    DOEpatents

    Benett, William J.; Miles, Robin; Jones, II., Leslie M.; Stockton, Cheryl

    2004-06-08

    A system for separating particles entrained in a fluid includes a base with a first channel and a second channel. A precision gap connects the first channel and the second channel. The precision gap is of a size that allows small particles to pass from the first channel into the second channel and prevents large particles from the first channel into the second channel. A cover is positioned over the base unit, the first channel, the precision gap, and the second channel. An port directs the fluid containing the entrained particles into the first channel. An output port directs the large particles out of the first channel. A port connected to the second channel directs the small particles out of the second channel.

  18. Precision electron polarimetry

    SciTech Connect

    Chudakov, Eugene A.

    2013-11-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. M{\\o}ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at ~300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100\\%-polarized electron target for M{\\o}ller polarimetry.

  19. Precision electron polarimetry

    NASA Astrophysics Data System (ADS)

    Chudakov, E.

    2013-11-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. Mo/ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at 300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100%-polarized electron target for Mo/ller polarimetry.

  20. Precision electron polarimetry

    SciTech Connect

    Chudakov, E.

    2013-11-07

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. Mo/ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at 300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100%-polarized electron target for Mo/ller polarimetry.

  1. Precision manometer gauge

    DOEpatents

    McPherson, M.J.; Bellman, R.A.

    1982-09-27

    A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

  2. Precision manometer gauge

    DOEpatents

    McPherson, Malcolm J.; Bellman, Robert A.

    1984-01-01

    A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

  3. Precision Heating Process

    NASA Technical Reports Server (NTRS)

    1992-01-01

    A heat sealing process was developed by SEBRA based on technology that originated in work with NASA's Jet Propulsion Laboratory. The project involved connecting and transferring blood and fluids between sterile plastic containers while maintaining a closed system. SEBRA markets the PIRF Process to manufacturers of medical catheters. It is a precisely controlled method of heating thermoplastic materials in a mold to form or weld catheters and other products. The process offers advantages in fast, precise welding or shape forming of catheters as well as applications in a variety of other industries.

  4. Teaching with Precision.

    ERIC Educational Resources Information Center

    Raybould, Ted; Solity, Jonathan

    1982-01-01

    Use of precision teaching principles with learning problem students involves five steps: specifying performance, recording daily behavior, charting daily behavior, recording the teaching approach, and analyzing data. The approach has been successfully implemented through consultation of school psychologists in Walsall, England. (CL)

  5. Precision bolometer bridge

    NASA Technical Reports Server (NTRS)

    White, D. R.

    1968-01-01

    Prototype precision bolometer calibration bridge is manually balanced device for indicating dc bias and balance with either dc or ac power. An external galvanometer is used with the bridge for null indication, and the circuitry monitors voltage and current simultaneously without adapters in testing 100 and 200 ohm thin film bolometers.

  6. Precision liquid level sensor

    DOEpatents

    Field, M.E.; Sullivan, W.H.

    1985-01-29

    A precision liquid level sensor utilizes a balanced R. F. bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge. 2 figs.

  7. Precision liquid level sensor

    DOEpatents

    Field, Michael E.; Sullivan, William H.

    1985-01-01

    A precision liquid level sensor utilizes a balanced R. F. bridge, each arm including an air dielectric line. Changes in liquid level along one air dielectric line imbalance the bridge and create a voltage which is directly measurable across the bridge.

  8. Possibility of high efficient beam extraction from the CERN SPS with a bent crystal. Simulation results

    NASA Astrophysics Data System (ADS)

    Scandale, W.; Kovalenko, A. D.; Taratin, A. M.

    2017-03-01

    The extraction of the SPS beam of 270 GeV/c protons assisted by a bent crystal was studied by simulation. Two methods for delivering the SPS beam onto a crystal were considered: transverse diffusion and orbit bump of the beam. It was shown that the main condition for high efficient beam extraction with a bent crystal, which is a small divergence of the incident beam, can be fulfilled. Extraction efficiency up to 99% can be reached for both methods of the beam delivering. The irradiation of the electrostatic septum wires during the beam extraction can be considerably reduced.

  9. A passion for precision

    ScienceCinema

    None

    2016-07-12

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  10. A passion for precision

    SciTech Connect

    2010-05-19

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  11. Precision disablement aiming system

    SciTech Connect

    Monda, Mark J.; Hobart, Clinton G.; Gladwell, Thomas Scott

    2016-02-16

    A disrupter to a target may be precisely aimed by positioning a radiation source to direct radiation towards the target, and a detector is positioned to detect radiation that passes through the target. An aiming device is positioned between the radiation source and the target, wherein a mechanical feature of the aiming device is superimposed on the target in a captured radiographic image. The location of the aiming device in the radiographic image is used to aim a disrupter towards the target.

  12. Ultra-Precision Optics

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Under a Joint Sponsored Research Agreement with Goddard Space Flight Center, SEMATECH, Inc., the Silicon Valley Group, Inc. and Tinsley Laboratories, known as SVG-Tinsley, developed an Ultra-Precision Optics Manufacturing System for space and microlithographic applications. Continuing improvements in optics manufacture will be able to meet unique NASA requirements and the production needs of the lithography industry for many years to come.

  13. Precision laser aiming system

    DOEpatents

    Ahrens, Brandon R.; Todd, Steven N.

    2009-04-28

    A precision laser aiming system comprises a disrupter tool, a reflector, and a laser fixture. The disrupter tool, the reflector and the laser fixture are configurable for iterative alignment and aiming toward an explosive device threat. The invention enables a disrupter to be quickly and accurately set up, aligned, and aimed in order to render safe or to disrupt a target from a standoff position.

  14. GOCE Precise Science Orbits

    NASA Astrophysics Data System (ADS)

    Bock, Heike; Jäggi, Adrian; Meyer, Ulrich; Beutler, Gerhard; Heinze, Markus; Hugentobler, Urs

    GOCE (Gravity field and steady-state Ocean Circulation Explorer), as the first ESA (European Space Agency) Earth Explorer Core Mission, is dedicated for gravity field recovery of unprece-dented accuracy using data from the gradiometer, its primary science instrument. Data from the secondary instrument, the 12-channel dual-frequency GPS (Global Positioning System) receiver, is used for precise orbit determination of the satellite. These orbits are used to accu-rately geolocate the gradiometer observations and to provide complementary information for the long-wavelength part of the gravity field. A precise science orbit (PSO) product is provided by the GOCE High-Level Processing Facility (HPF) with a precision of about 2 cm and a 1-week latency. The reduced-dynamic and kinematic orbit determination strategies for the PSO product are presented together with results of about one year of data. The focus is on the improvement achieved by the use of empirically derived azimuth-and elevation-dependent variations of the phase center of the GOCE GPS antenna. The orbits are validated with satellite laser ranging (SLR) measurements.

  15. Beam-Based Alignment of the NLC Main Linac, Part Two: Dispersion-Free Steering and Dispersion Bumps(LCC-0071)

    SciTech Connect

    Tenenbaum, P

    2003-11-06

    The standard prescription for NLC main linac steering assumes that the RMS offset between a quad's magnetic center and the corresponding BPM's electrical center can be determined at the level of a micron. This is a fearsome requirement, and will be particularly difficult to achieve if hybrid iron/permanent magnet quads are used in the main linac. As an alternative, the Dispersion Free Steering (DFS) [1] algorithm is adapted to the NLC main linac environment; the DFS algorithm does not require knowledge of the quad-BPM offsets. The results of simulation studies of this adaptation are presented. In addition, the use of closed orbit bumps to globally correct dispersive emittance growth is considered. The studies indicate that DFS can be used successfully in the NLC main linac environment, and that dispersion bumps are a useful addition to the linac steering ''toolbox,'' regardless of the main algorithm selected.

  16. X-ray bumps, iron K-alpha lines, and X-ray suppression by obscuring tori in Seyfert galaxies

    NASA Technical Reports Server (NTRS)

    Krolik, Julian H.; Madau, Piero; Zycki, Piotr T.

    1994-01-01

    We investigate the X-ray spectral properties of unobscured type 1 and obscured type 2 Seyferts as predicted by the unified Seyfert scheme. We consider the reprocessing of X-ray photons by photoelectric absorption, iron fluorescence, and Compton downscattering in the obscuring tori surrounding these active nuclei, and compute by Monte Carlo methods the reprocessed spectra as a function of the viewing angle. Depending on the optical depth and shape of the torus, and on the viewing angle, the X-ray flux can be suppressed by substantial factors when our line of sight is obscured. We show that an immediate consequence of the existence of an obscuring thick torus is the production in the spectra of type 1 Seyfert galaxies of a bump in the continuum above 10-20 keV and an Fe K-alpha line with significant equivalent width. In those type 2 Seyferts for which the hard X-ray spectrum has been substantially suppressed, the equivalent width of the Fe K-alpha line in the transmitted spectrum can be very large.

  17. Elliptically polarised soft x-rays produced using a local bump in MAX II - Characterisation of the degree of polarisation

    SciTech Connect

    Dunn, J. Hunter; LeBlanc, G.; Andersson, A.; Lindgren, L.-J.; Hahlin, A.; Karis, O.; Arvanitis, D.

    2004-05-12

    MAX-lab has introduced a local perturbation to the electron orbit of the MAX II storage ring, providing users at the SX700 monochromator beam line, D1011, with elliptically polarised soft x-rays. This is achieved by using corrector magnets to send the electron orbit on an ascending or descending trajectory through the dipole magnet source. This simple 'bump' approach has many advantages over and above insertion device based solutions. To illustrate the potential of the approach, the degree of circular polarisation, Pc, has both been calculated and measured. The calculation was made by applying the Stokes formalism to the intensities given by the standard dipole emission formula. Experimentally Pc was characterised using x-ray magnetic circular dichroism measurements. In such experiments magnetic contrast scales directly proportional to Pc. Using a 25 atomic layer bcc Fe film deposited on the Cu(100) surface as a calibration standard the spin moment, ms, was determined. By comparing the values of ms obtained here with those reported earlier, the degree of circular polarisation could be estimated. At {approx} 715 eV the calculated and measured values of Pc are 0.93 and 0.85, respectively.

  18. Experimental Studies on the Effects of Thermal Bumps in the Flow-Field around a Flat Plate using a Hypersonic Wind Tunnel

    DTIC Science & Technology

    2012-07-01

    and stagnation pressure losses associated with heating . An increase of 11% mass flow rate is estimated from the CFD results by energy deposition of 2...diameter to simulate the thermal bump. Quantitative heat transfer measurements were performed using IR-thermography. The surface pressure...of heat flux calculation based on the surface temperature history is given. The theoretical predictions of heat transfer coefficient over the flat

  19. Mean-time-to-failure study of flip chip solder joints on Cu/Ni(V)/Al thin-film under-bump-metallization

    NASA Astrophysics Data System (ADS)

    Choi, W. J.; Yeh, E. C. C.; Tu, K. N.

    2003-11-01

    Electromigration of eutectic SnPb flip chip solder joints and their mean-time-to-failure (MTTF) have been studied in the temperature range of 100 to 140 °C with current densities of 1.9 to 2.75×104 A/cm2. In these joints, the under-bump-metallization (UBM) on the chip side is a multilayer thin film of Al/Ni(V)/Cu, and the metallic bond-pad on the substrate side is a very thick, electroless Ni layer covered with 30 nm of Au. When stressed at the higher current densities, the MTTF was found to decrease much faster than what is expected from the published Black's equation. The failure occurred by interfacial void propagation at the cathode side, and it is due to current crowding near the contact interface between the solder bump and the thin-film UBM. The current crowding is confirmed by a simulation of current distribution in the solder joint. Besides the interfacial void formation, the intermetallic compounds formed on the UBM as well as the Ni(V) film in the UBM have been found to dissolve completely into the solder bump during electromigration. Therefore, the electromigation failure is a combination of the interfacial void formation and the loss of UBM. Similar findings in eutectic SnAgCu flip chip solder joints have also been obtained and compared.

  20. The application of the gradient-based adjoint multi-point optimization of single and double shock control bumps for transonic airfoils

    NASA Astrophysics Data System (ADS)

    Mazaheri, K.; Nejati, A.; Chaharlang Kiani, K.; Taheri, R.

    2016-07-01

    A shock control bump (SCB) is a flow control method that uses local small deformations in a flexible wing surface to considerably reduce the strength of shock waves and the resulting wave drag in transonic flows. Most of the reported research is devoted to optimization in a single flow condition. Here, we have used a multi-point adjoint optimization scheme to optimize shape and location of the SCB. Practically, this introduces transonic airfoils equipped with the SCB that are simultaneously optimized for different off-design transonic flight conditions. Here, we use this optimization algorithm to enhance and optimize the performance of SCBs in two benchmark airfoils, i.e., RAE-2822 and NACA-64-A010, over a wide range of off-design Mach numbers. All results are compared with the usual single-point optimization. We use numerical simulation of the turbulent viscous flow and a gradient-based adjoint algorithm to find the optimum location and shape of the SCB. We show that the application of SCBs may increase the aerodynamic performance of an RAE-2822 airfoil by 21.9 and by 22.8 % for a NACA-64-A010 airfoil compared to the no-bump design in a particular flight condition. We have also investigated the simultaneous usage of two bumps for the upper and the lower surfaces of the airfoil. This has resulted in a 26.1 % improvement for the RAE-2822 compared to the clean airfoil in one flight condition.

  1. USING THE 1.6 {mu}m BUMP TO STUDY REST-FRAME NEAR-INFRARED-SELECTED GALAXIES AT REDSHIFT 2

    SciTech Connect

    Sorba, Robert; Sawicki, Marcin

    2010-10-01

    We explore the feasibility and limitations of using the 1.6 {mu}m bump as a photometric redshift indicator and selection technique, and use it to study the rest-frame H-band galaxy luminosity and stellar mass functions (SMFs) at redshift z {approx} 2. We use publicly available Spitzer/IRAC images in the GOODS fields and find that color selection in the IRAC bandpasses alone is comparable in completeness and contamination to BzK selection. We find that the shape of the 1.6 {mu}m bump is robust, and photometric redshifts are not greatly affected by choice of model parameters. Comparison with spectroscopic redshifts shows photometric redshifts to be reliable. We create a rest-frame NIR-selected catalog of galaxies at z {approx} 2 and construct a galaxy SMF. Comparisons with other SMFs at approximately the same redshift but determined using shorter wavelengths show good agreement. This agreement suggests that selection at bluer wavelengths does not miss a significant amount of stellar mass in passive galaxies. Comparison with SMFs at other redshifts shows evidence for the downsizing scenario of galaxy evolution. We conclude by pointing out the potential for using the 1.6 {mu}m bump technique to select high-redshift galaxies with the JWST, whose {lambda}>0.6 {mu}m coverage will not be well suited to selecting galaxies using techniques that require imaging at shorter wavelengths.

  2. Laser generation of elliptical nanometre and sub-nanometre bump arrays on NiP/Al data storage disks and their effect on stiction performance.

    PubMed

    Pena, A A; Wang, Z B; Zhang, J; Wu, N E; Li, L

    2011-09-07

    Elliptical nano-bumps on nickel-phosphorus coated aluminium (NiP/Al) hard disks were fabricated by a laser texturing system (maximum power 8 W, maximum frequency 300 kHz). By carefully selecting the level of laser power attenuation and defocus offset distance, bump height can be controlled below 6 nm and down to the sub-nanometre scale. This type of laser-induced texture (elliptical shape) on a disk surface is expected to provide better control of the stiction force along with the smallest separation distance between the head slider and the disk. Quantitative modelling based on the classical Hertzian theory for elliptic contacts has been carried out with the purpose of predicting the stiction behaviour of the presented elliptical shaped sub-10 nm bumps. It has been found that an elliptical shape not only reduces the overall stiction performance of the laser texturing zone (LZT) compared to the conventional circular shape but also extends the occurrence of the 'stiction wall' towards the sub-10 nm regime for ultra-low-glide applications.

  3. IS THE LATE NEAR-INFRARED BUMP IN SHORT-HARD GRB 130603B DUE TO THE LI-PACZYNSKI KILONOVA?

    SciTech Connect

    Jin, Zhi-Ping; Fan, Yi-Zhong; Wei, Da-Ming; Xu, Dong; Wu, Xue-Feng

    2013-09-20

    Short-hard gamma-ray bursts (GRBs) are widely believed to be produced by the merger of two binary compact objects, specifically by two neutron stars or by a neutron star orbiting a black hole. According to the Li-Paczynski kilonova model, the merger would launch sub-relativistic ejecta and a near-infrared/optical transient would then occur, lasting up to days, which is powered by the radioactive decay of heavy elements synthesized in the ejecta. The detection of a late bump using the Hubble Space Telescope (HST) in the near-infrared afterglow light curve of the short-hard GRB 130603B is indeed consistent with such a model. However, as shown in this Letter, the limited HST near-infrared light curve behavior can also be interpreted as the synchrotron radiation of the external shock driven by a wide mildly relativistic outflow. In such a scenario, the radio emission is expected to peak with a flux of ∼100 μJy, which is detectable for current radio arrays. Hence, the radio afterglow data can provide complementary evidence on the nature of the bump in GRB 130603B. It is worth noting that good spectroscopy during the bump phase in short-hard bursts can test the validity of either model above, analogous to spectroscopy of broad-lined Type Ic supernova in long-soft GRBs.

  4. Fast, High-Precision Readout Circuit for Detector Arrays

    NASA Technical Reports Server (NTRS)

    Rider, David M.; Hancock, Bruce R.; Key, Richard W.; Cunningham, Thomas J.; Wrigley, Chris J.; Seshadri, Suresh; Sander, Stanley P.; Blavier, Jean-Francois L.

    2013-01-01

    The GEO-CAPE mission described in NASA's Earth Science and Applications Decadal Survey requires high spatial, temporal, and spectral resolution measurements to monitor and characterize the rapidly changing chemistry of the troposphere over North and South Americas. High-frame-rate focal plane arrays (FPAs) with many pixels are needed to enable such measurements. A high-throughput digital detector readout integrated circuit (ROIC) that meets the GEO-CAPE FPA needs has been developed, fabricated, and tested. The ROIC is based on an innovative charge integrating, fast, high-precision analog-to-digital circuit that is built into each pixel. The 128×128-pixel ROIC digitizes all 16,384 pixels simultaneously at frame rates up to 16 kHz to provide a completely digital output on a single integrated circuit at an unprecedented rate of 262 million pixels per second. The approach eliminates the need for off focal plane electronics, greatly reducing volume, mass, and power compared to conventional FPA implementations. A focal plane based on this ROIC will require less than 2 W of power on a 1×1-cm integrated circuit. The ROIC is fabricated of silicon using CMOS technology. It is designed to be indium bump bonded to a variety of detector materials including silicon PIN diodes, indium antimonide (InSb), indium gallium arsenide (In- GaAs), and mercury cadmium telluride (HgCdTe) detector arrays to provide coverage over a broad spectral range in the infrared, visible, and ultraviolet spectral ranges.

  5. Instrument Attitude Precision Control

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan

    2004-01-01

    A novel approach is presented in this paper to analyze attitude precision and control for an instrument gimbaled to a spacecraft subject to an internal disturbance caused by a moving component inside the instrument. Nonlinear differential equations of motion for some sample cases are derived and solved analytically to gain insight into the influence of the disturbance on the attitude pointing error. A simple control law is developed to eliminate the instrument pointing error caused by the internal disturbance. Several cases are presented to demonstrate and verify the concept presented in this paper.

  6. Precise Measurement for Manufacturing

    NASA Technical Reports Server (NTRS)

    2003-01-01

    A metrology instrument known as PhaseCam supports a wide range of applications, from testing large optics to controlling factory production processes. This dynamic interferometer system enables precise measurement of three-dimensional surfaces in the manufacturing industry, delivering speed and high-resolution accuracy in even the most challenging environments.Compact and reliable, PhaseCam enables users to make interferometric measurements right on the factory floor. The system can be configured for many different applications, including mirror phasing, vacuum/cryogenic testing, motion/modal analysis, and flow visualization.

  7. Precision Robotic Assembly Machine

    ScienceCinema

    None

    2016-07-12

    The world's largest laser system is the National Ignition Facility (NIF), located at Lawrence Livermore National Laboratory. NIF's 192 laser beams are amplified to extremely high energy, and then focused onto a tiny target about the size of a BB, containing frozen hydrogen gas. The target must be perfectly machined to incredibly demanding specifications. The Laboratory's scientists and engineers have developed a device called the "Precision Robotic Assembly Machine" for this purpose. Its unique design won a prestigious R&D-100 award from R&D Magazine.

  8. Precision electroweak measurements

    SciTech Connect

    Demarteau, M.

    1996-11-01

    Recent electroweak precision measurements fro {ital e}{sup +}{ital e}{sup -} and {ital p{anti p}} colliders are presented. Some emphasis is placed on the recent developments in the heavy flavor sector. The measurements are compared to predictions from the Standard Model of electroweak interactions. All results are found to be consistent with the Standard Model. The indirect constraint on the top quark mass from all measurements is in excellent agreement with the direct {ital m{sub t}} measurements. Using the world`s electroweak data in conjunction with the current measurement of the top quark mass, the constraints on the Higgs` mass are discussed.

  9. Precision Joining Center

    SciTech Connect

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  10. Precision flyer initiator

    DOEpatents

    Frank, A.M.; Lee, R.S.

    1998-05-26

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or ``flyer`` is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices. 10 figs.

  11. Precision flyer initiator

    DOEpatents

    Frank, Alan M.; Lee, Ronald S.

    1998-01-01

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or "flyer" is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices.

  12. Ultra Precision Machining.

    DTIC Science & Technology

    1985-12-01

    literature review has turned up very little information . One citation (Nanometer Positioning Characteristics of Closed Looped Differential Hydro or Aerostatic... systems provide information that allows sources to be distinguished and noise extracted from signals. The latter has been done by Chaturvedi and Thomas...the accessability and the friendliness of information to the operator. These areas are summarized below in this order with sensing, actuation, and

  13. Probing active-edge silicon sensors using a high precision telescope

    NASA Astrophysics Data System (ADS)

    Akiba, K.; Artuso, M.; van Beveren, V.; van Beuzekom, M.; Boterenbrood, H.; Buytaert, J.; Collins, P.; Dumps, R.; van der Heijden, B.; Hombach, C.; Hynds, D.; Hsu, D.; John, M.; Koffeman, E.; Leflat, A.; Li, Y.; Longstaff, I.; Morton, A.; Pérez Trigo, E.; Plackett, R.; Reid, M. M.; Rodríguez Perez, P.; Schindler, H.; Tsopelas, P.; Vázquez Sierra, C.; Wysokiński, M.

    2015-03-01

    The performance of prototype active-edge VTT sensors bump-bonded to the Timepix ASIC is presented. Non-irradiated sensors of thicknesses 100-200 μm and pixel-to-edge distances of 50 μm and 100 μm were probed with a beam of charged hadrons with sub-pixel precision using the Timepix telescope assembled at the SPS at CERN. The sensors are shown to be highly efficient up to a few micrometers from the physical edge of the sensor. The distortion of the electric field lines at the edge of the sensors is studied by reconstructing the streamlines of the electric field using two-pixel clusters. These results are supported by TCAD simulations. The reconstructed streamlines are used to study the field distortion as a function of the bias voltage and to apply corrections to the cluster positions at the edge.

  14. An Extended Keyword Extraction Method

    NASA Astrophysics Data System (ADS)

    Hong, Bao; Zhen, Deng

    Among numerous Chinese keyword extraction methods, Chinese characteristics were shortly considered. This phenomenon going against the precision enhancement of the Chinese keyword extraction. An extended term frequency based method(Extended TF) is proposed in this paper which combined Chinese linguistic characteristics with basic TF method. Unary, binary and ternary grammars for the candidate keyword extraction as well as other linguistic features were all taken into account. The method establishes classification model using support vector machine. Tests show that the proposed extraction method improved key words precision and recall rate significantly. We applied the key words extracted by the extended TF method into the text file classification. Results show that the key words extracted by the proposed method contributed greatly to raising the precision of text file classification.

  15. Precision Medicine in Cancer Treatment

    Cancer.gov

    Precision medicine helps doctors select cancer treatments that are most likely to help patients based on a genetic understanding of their disease. Learn about the promise of precision medicine and the role it plays in cancer treatment.

  16. Precision Joining Center

    NASA Technical Reports Server (NTRS)

    Powell, John W.

    1991-01-01

    The establishment of a Precision Joining Center (PJC) is proposed. The PJC will be a cooperatively operated center with participation from U.S. private industry, the Colorado School of Mines, and various government agencies, including the Department of Energy's Nuclear Weapons Complex (NWC). The PJC's primary mission will be as a training center for advanced joining technologies. This will accomplish the following objectives: (1) it will provide an effective mechanism to transfer joining technology from the NWC to private industry; (2) it will provide a center for testing new joining processes for the NWC and private industry; and (3) it will provide highly trained personnel to support advance joining processes for the NWC and private industry.

  17. Precision spectroscopy of Helium

    SciTech Connect

    Cancio, P.; Giusfredi, G.; Mazzotti, D.; De Natale, P.; De Mauro, C.; Krachmalnicoff, V.; Inguscio, M.

    2005-05-05

    Accurate Quantum-Electrodynamics (QED) tests of the simplest bound three body atomic system are performed by precise laser spectroscopic measurements in atomic Helium. In this paper, we present a review of measurements between triplet states at 1083 nm (23S-23P) and at 389 nm (23S-33P). In 4He, such data have been used to measure the fine structure of the triplet P levels and, then, to determine the fine structure constant when compared with equally accurate theoretical calculations. Moreover, the absolute frequencies of the optical transitions have been used for Lamb-shift determinations of the levels involved with unprecedented accuracy. Finally, determination of the He isotopes nuclear structure and, in particular, a measurement of the nuclear charge radius, are performed by using hyperfine structure and isotope-shift measurements.

  18. Precision Spectroscopy of Tellurium

    NASA Astrophysics Data System (ADS)

    Coker, J.; Furneaux, J. E.

    2013-06-01

    Tellurium (Te_2) is widely used as a frequency reference, largely due to the fact that it has an optical transition roughly every 2-3 GHz throughout a large portion of the visible spectrum. Although a standard atlas encompassing over 5200 cm^{-1} already exists [1], Doppler broadening present in that work buries a significant portion of the features [2]. More recent studies of Te_2 exist which do not exhibit Doppler broadening, such as Refs. [3-5], and each covers different parts of the spectrum. This work adds to that knowledge a few hundred transitions in the vicinity of 444 nm, measured with high precision in order to improve measurement of the spectroscopic constants of Te_2's excited states. Using a Fabry Perot cavity in a shock-absorbing, temperature and pressure regulated chamber, locked to a Zeeman stabilized HeNe laser, we measure changes in frequency of our diode laser to ˜1 MHz precision. This diode laser is scanned over 1000 GHz for use in a saturated-absorption spectroscopy cell filled with Te_2 vapor. Details of the cavity and its short and long-term stability are discussed, as well as spectroscopic properties of Te_2. References: J. Cariou, and P. Luc, Atlas du spectre d'absorption de la molecule de tellure, Laboratoire Aime-Cotton (1980). J. Coker et al., J. Opt. Soc. Am. B {28}, 2934 (2011). J. Verges et al., Physica Scripta {25}, 338 (1982). Ph. Courteille et al., Appl. Phys. B {59}, 187 (1994) T.J. Scholl et al., J. Opt. Soc. Am. B {22}, 1128 (2005).

  19. Mathematics for modern precision engineering.

    PubMed

    Scott, Paul J; Forbes, Alistair B

    2012-08-28

    The aim of precision engineering is the accurate control of geometry. For this reason, mathematics has a long association with precision engineering: from the calculation and correction of angular scales used in surveying and astronomical instrumentation to statistical averaging techniques used to increase precision. This study illustrates the enabling role the mathematical sciences are playing in precision engineering: modelling physical processes, instruments and complex geometries, statistical characterization of metrology systems and error compensation.

  20. Precision cosmological parameter estimation

    NASA Astrophysics Data System (ADS)

    Fendt, William Ashton, Jr.

    2009-09-01

    Experimental efforts of the last few decades have brought. a golden age to mankind's endeavor to understand tine physical properties of the Universe throughout its history. Recent measurements of the cosmic microwave background (CMB) provide strong confirmation of the standard big bang paradigm, as well as introducing new mysteries, to unexplained by current physical models. In the following decades. even more ambitious scientific endeavours will begin to shed light on the new physics by looking at the detailed structure of the Universe both at very early and recent times. Modern data has allowed us to begins to test inflationary models of the early Universe, and the near future will bring higher precision data and much stronger tests. Cracking the codes hidden in these cosmological observables is a difficult and computationally intensive problem. The challenges will continue to increase as future experiments bring larger and more precise data sets. Because of the complexity of the problem, we are forced to use approximate techniques and make simplifying assumptions to ease the computational workload. While this has been reasonably sufficient until now, hints of the limitations of our techniques have begun to come to light. For example, the likelihood approximation used for analysis of CMB data from the Wilkinson Microwave Anistropy Probe (WMAP) satellite was shown to have short falls, leading to pre-emptive conclusions drawn about current cosmological theories. Also it can he shown that an approximate method used by all current analysis codes to describe the recombination history of the Universe will not be sufficiently accurate for future experiments. With a new CMB satellite scheduled for launch in the coming months, it is vital that we develop techniques to improve the analysis of cosmological data. This work develops a novel technique of both avoiding the use of approximate computational codes as well as allowing the application of new, more precise analysis

  1. Precise measurement of planeness.

    PubMed

    Schulz, G; Schwider, J

    1967-06-01

    Interference methods are reviewed-particularly those developed at the German Academy of Sciences in Berlin-with which the deviations of an optically flat surface from the ideal plane can be measured with a high degree of exactness. One aid to achieve this is the relative methods which measure the differences in planeness between two surfaces. These are then used in the absolute methods which determine the absolute planeness of a surface. This absolute determination can be effected in connection with a liquid surface, or (as done by the authors) only by suitable evaluation of relative measurements between unknown plates in various positional combinations. Experimentally, one uses two- or multiple-beam interference fringes of equal thickness(1) or of equal inclination. The fringes are observed visually, scanned, or photographed, and in part several wavelengths or curves of equal density (Aquidensiten) are employed. The survey also brings the following new methods: a relative method, where, with the aid of fringes of superposition, the fringe separation is subdivided equidistantly thus achieving an increase of measuring precision, and an absolute method which determines the deviations of a surface from ideal planeness along arbitrary central sections, without a liquid surface, from four relative interference photographs.

  2. Prompt and Precise Prototyping

    NASA Technical Reports Server (NTRS)

    2003-01-01

    For Sanders Design International, Inc., of Wilton, New Hampshire, every passing second between the concept and realization of a product is essential to succeed in the rapid prototyping industry where amongst heavy competition, faster time-to-market means more business. To separate itself from its rivals, Sanders Design aligned with NASA's Marshall Space Flight Center to develop what it considers to be the most accurate rapid prototyping machine for fabrication of extremely precise tooling prototypes. The company's Rapid ToolMaker System has revolutionized production of high quality, small-to-medium sized prototype patterns and tooling molds with an exactness that surpasses that of computer numerically-controlled (CNC) machining devices. Created with funding and support from Marshall under a Small Business Innovation Research (SBIR) contract, the Rapid ToolMaker is a dual-use technology with applications in both commercial and military aerospace fields. The advanced technology provides cost savings in the design and manufacturing of automotive, electronic, and medical parts, as well as in other areas of consumer interest, such as jewelry and toys. For aerospace applications, the Rapid ToolMaker enables fabrication of high-quality turbine and compressor blades for jet engines on unmanned air vehicles, aircraft, and missiles.

  3. Arrival Metering Precision Study

    NASA Technical Reports Server (NTRS)

    Prevot, Thomas; Mercer, Joey; Homola, Jeffrey; Hunt, Sarah; Gomez, Ashley; Bienert, Nancy; Omar, Faisal; Kraut, Joshua; Brasil, Connie; Wu, Minghong, G.

    2015-01-01

    This paper describes the background, method and results of the Arrival Metering Precision Study (AMPS) conducted in the Airspace Operations Laboratory at NASA Ames Research Center in May 2014. The simulation study measured delivery accuracy, flight efficiency, controller workload, and acceptability of time-based metering operations to a meter fix at the terminal area boundary for different resolution levels of metering delay times displayed to the air traffic controllers and different levels of airspeed information made available to the Time-Based Flow Management (TBFM) system computing the delay. The results show that the resolution of the delay countdown timer (DCT) on the controllers display has a significant impact on the delivery accuracy at the meter fix. Using the 10 seconds rounded and 1 minute rounded DCT resolutions resulted in more accurate delivery than 1 minute truncated and were preferred by the controllers. Using the speeds the controllers entered into the fourth line of the data tag to update the delay computation in TBFM in high and low altitude sectors increased air traffic control efficiency and reduced fuel burn for arriving aircraft during time based metering.

  4. Precise Truss Assembly using Commodity Parts and Low Precision Welding

    NASA Technical Reports Server (NTRS)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, William R.; Correll, Nikolaus

    2013-01-01

    We describe an Intelligent Precision Jigging Robot (IPJR), which allows high precision assembly of commodity parts with low-precision bonding. We present preliminary experiments in 2D that are motivated by the problem of assembling a space telescope optical bench on orbit using inexpensive, stock hardware and low-precision welding. An IPJR is a robot that acts as the precise "jigging", holding parts of a local assembly site in place while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (in this case, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. We report the challenges of designing the IPJR hardware and software, analyze the error in assembly, document the test results over several experiments including a large-scale ring structure, and describe future work to implement the IPJR in 3D and with micron precision.

  5. Precise Truss Assembly Using Commodity Parts and Low Precision Welding

    NASA Technical Reports Server (NTRS)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, W. R.; Correll, Nikolaus

    2014-01-01

    Hardware and software design and system integration for an intelligent precision jigging robot (IPJR), which allows high precision assembly using commodity parts and low-precision bonding, is described. Preliminary 2D experiments that are motivated by the problem of assembling space telescope optical benches and very large manipulators on orbit using inexpensive, stock hardware and low-precision welding are also described. An IPJR is a robot that acts as the precise "jigging", holding parts of a local structure assembly site in place, while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (for this prototype, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. The analysis of the assembly error and the results of building a square structure and a ring structure are discussed. Options for future work, to extend the IPJR paradigm to building in 3D structures at micron precision are also summarized.

  6. [Precision nutrition in the era of precision medicine].

    PubMed

    Chen, P Z; Wang, H

    2016-12-06

    Precision medicine has been increasingly incorporated into clinical practice and is enabling a new era for disease prevention and treatment. As an important constituent of precision medicine, precision nutrition has also been drawing more attention during physical examinations. The main aim of precision nutrition is to provide safe and efficient intervention methods for disease treatment and management, through fully considering the genetics, lifestyle (dietary, exercise and lifestyle choices), metabolic status, gut microbiota and physiological status (nutrient level and disease status) of individuals. Three major components should be considered in precision nutrition, including individual criteria for sufficient nutritional status, biomarker monitoring or techniques for nutrient detection and the applicable therapeutic or intervention methods. It was suggested that, in clinical practice, many inherited and chronic metabolic diseases might be prevented or managed through precision nutritional intervention. For generally healthy populations, because lifestyles, dietary factors, genetic factors and environmental exposures vary among individuals, precision nutrition is warranted to improve their physical activity and reduce disease risks. In summary, research and practice is leading toward precision nutrition becoming an integral constituent of clinical nutrition and disease prevention in the era of precision medicine.

  7. Transient Superstrong Coronal Lines and Broad Bumps in the Galaxy SDSS J074820.67+471214.3

    NASA Astrophysics Data System (ADS)

    Wang, Ting-Gui; Zhou, Hong-Yan; Wang, Li-Fan; Lu, Hong-Lin; Xu, Dawei

    2011-10-01

    Variable superstrong coronal emission lines were observed in the spectrum of one galaxy, SDSS J095209.56+214313.3, and their enigmatic origin remains controversial. In this paper, we report the detection of variable broad emission bumps reminiscent of a supernova (SN) II-Plateau spectra taken a few days after the shock breakout in a second galaxy with variable superstrong coronal lines, SDSS J074820.67+471214.3. The coronal line spectrum shows unprecedentedly high ionization with superstrong [Fe X]λ6376, [Fe XI]λ7894, [Fe XIV]λ5304, [S XII]λ7612, and [Ar XIV]λ4414, but without detectable optical [Fe VII] line emission. The coronal line luminosities are similar to those observed in bright Seyfert galaxies and 20 times more luminous than those reported in the hottest Type IIn SN 2005ip inferred from its strong coronal lines. The coronal lines (σ ~ 120-240 km s-1) are much broader than the narrow emission lines (σ ~ 40 km s-1) from the star-forming regions in the galaxy, but are nearly at the same systematic redshift. We also detected a variable non-stellar continuum emission from its Sloan Digital Sky Survey spectroscopy and Galaxy Evolution Explorer photometry. In the follow-up spectra taken 4-5 years later, the coronal lines, SN-like feature, and non-stellar continuum disappeared, while the [O III]λ5007 intensity increased by a factor of about 10. Our analysis suggests that the coronal line region should be at least 10 light days in size and should be powered either by a steady ionizing source with a soft X-ray luminosity of at least a few 1042 erg s-1 or by a very luminous soft X-ray outburst. These findings can be more naturally explained by a star tidally disrupted by the central black hole than by an SN explosion. The similarity of the coronal line variability trend observed in the two galaxies suggests that the two transient events have the same origin, with SDSS J074820.67+471214.3 being caught at an earlier stage by the spectroscopic observation.

  8. DISCOVERY OF A RICH CLUSTER AT z = 1.63 USING THE REST-FRAME 1.6 {mu}m 'STELLAR BUMP SEQUENCE' METHOD

    SciTech Connect

    Muzzin, Adam; Hoekstra, Henk; Wilson, Gillian; Demarco, Ricardo; Nantais, Julie; Lidman, Chris; Yee, H. K. C.; Rettura, Alessandro

    2013-04-10

    We present a new two-color algorithm, the 'Stellar Bump Sequence' (SBS), that is optimized for robustly identifying candidate high-redshift galaxy clusters in combined wide-field optical and mid-infrared (MIR) data. The SBS algorithm is a fusion of the well-tested cluster red-sequence method of Gladders and Yee with the MIR 3.6 {mu}m-4.5 {mu}m cluster detection method developed by Papovich. As with the cluster red-sequence method, the SBS identifies candidate overdensities within 3.6 {mu}m-4.5 {mu}m color slices, which are the equivalent of a rest-frame 1.6 {mu}m stellar bump 'red-sequence'. In addition to employing the MIR colors of galaxies, the SBS algorithm incorporates an optical/MIR (z'-3.6 {mu}m) color cut. This cut effectively eliminates foreground 0.2 1.0 galaxies and add noise when searching for high-redshift galaxy overdensities. We demonstrate using the z {approx} 1 GCLASS cluster sample that similar to the red sequence, the stellar bump sequence appears to be a ubiquitous feature of high-redshift clusters, and that within that sample the color of the stellar bump sequence increases monotonically with redshift and provides photometric redshifts accurate to {Delta}z = 0.05. We apply the SBS method in the XMM-LSS SWIRE field and show that it robustly recovers the majority of confirmed optical, MIR, and X-ray-selected clusters at z > 1.0 in that field. Lastly, we present confirmation of SpARCS J022427-032354 at z = 1.63, a new cluster detected with the method and confirmed with 12 high-confidence spectroscopic redshifts obtained using FORS2 on the Very Large Telescope. We conclude with a discussion of future prospects for using the algorithm.

  9. Sfermion precision measurements at a linear collider

    SciTech Connect

    A. Freitas et al.

    2003-09-25

    At future e{sup +}e{sup -} linear colliders, the event rates and clean signals of scalar fermion production--in particular for the scalar leptons--allow very precise measurements of their masses and couplings and the determination of their quantum numbers. Various methods are proposed for extracting these parameters from the data at the sfermion thresholds and in the continuum. At the same time, NLO radiative corrections and non-zero width effects have been calculated in order to match the experimental accuracy. The substantial mixing expected for the third generation sfermions opens up additional opportunities. Techniques are presented for determining potential CP-violating phases and for extracting tan {beta} from the stau sector, in particular at high values. The consequences of possible large mass differences in the stop and sbottom system are explored in dedicated analyses.

  10. Apparatus Makes Precisely Saturated Solutions

    NASA Technical Reports Server (NTRS)

    Pusey, Marc L.

    1989-01-01

    Simple laboratory apparatus establishes equilibrium conditions of temperature and concentration in solutions for use in precise measurements of saturation conditions. With equipment typical measurement of saturation concentration of protein in solution established and measured within about 24 hours. Precisely saturated solution made by passing solvent or solution slowly along column packed with solute at precisely controlled temperature. If necessary, flow stopped for experimentally determined interval to allow equilibrium to be established in column.

  11. Precision Astronomy with Imperfect Deep Depletion CCDs

    NASA Astrophysics Data System (ADS)

    Stubbs, Christopher; LSST Sensor Team; PanSTARRS Team

    2014-01-01

    While thick CCDs do provide definite advantages in terms of increased quantum efficiency at wavelengths 700 nm<λ < 1.1 microns and reduced fringing from atmospheric emission lines, these devices also exhibit undesirable features that pose a challenge to precision determination of the positions, fluxes, and shapes of astronomical objects, and for the precision extraction of features in astronomical spectra. For example, the assumptions of a perfectly rectilinear pixel grid and of an intensity-independent point spread function become increasingly invalid as we push to higher precision measurements. Many of the effects seen in these devices arise from lateral electrical fields within the detector, that produce charge transport anomalies that have been previously misinterpreted as quantum efficiency variations. Performing simplistic flat-fielding therefore introduces systematic errors in the image processing pipeline. One measurement challenge we face is devising a combination of calibration methods and algorithms that can distinguish genuine quantum efficiency variations from charge transport effects. These device imperfections also confront spectroscopic applications, such as line centroid determination for precision radial velocity studies. Given the scientific benefits of improving both the precision and accuracy of astronomical measurements, we need to identify, characterize, and overcome these various detector artifacts. In retrospect, many of the detector features first identified in thick CCDs also afflict measurements made with more traditional CCD detectors, albeit often at a reduced level since the photocharge is subject to the perturbing influence of lateral electric fields for a shorter time interval. I provide a qualitative overview of the physical effects we think are responsible for the observed device properties, and provide some perspective for the work that lies ahead.

  12. Precision measurements of linear scattering density using muon tomography

    NASA Astrophysics Data System (ADS)

    Åström, E.; Bonomi, G.; Calliari, I.; Calvini, P.; Checchia, P.; Donzella, A.; Faraci, E.; Forsberg, F.; Gonella, F.; Hu, X.; Klinger, J.; Sundqvist Ökvist, L.; Pagano, D.; Rigoni, A.; Ramous, E.; Urbani, M.; Vanini, S.; Zenoni, A.; Zumerle, G.

    2016-07-01

    We demonstrate that muon tomography can be used to precisely measure the properties of various materials. The materials which have been considered have been extracted from an experimental blast furnace, including carbon (coke) and iron oxides, for which measurements of the linear scattering density relative to the mass density have been performed with an absolute precision of 10%. We report the procedures that are used in order to obtain such precision, and a discussion is presented to address the expected performance of the technique when applied to heavier materials. The results we obtain do not depend on the specific type of material considered and therefore they can be extended to any application.

  13. Centroid precision and orientation precision of planar localization microscopy.

    PubMed

    McGray, C; Copeland, C R; Stavis, S M; Geist, J

    2016-09-01

    The concept of localization precision, which is essential to localization microscopy, is formally extended from optical point sources to microscopic rigid bodies. Measurement functions are presented to calculate the planar pose and motion of microscopic rigid bodies from localization microscopy data. Physical lower bounds on the associated uncertainties - termed centroid precision and orientation precision - are derived analytically in terms of the characteristics of the optical measurement system and validated numerically by Monte Carlo simulations. The practical utility of these expressions is demonstrated experimentally by an analysis of the motion of a microelectromechanical goniometer indicated by a sparse constellation of fluorescent nanoparticles. Centroid precision and orientation precision, as developed here, are useful concepts due to the generality of the expressions and the widespread interest in localization microscopy for super-resolution imaging and particle tracking.

  14. More Questions on Precision Teaching.

    ERIC Educational Resources Information Center

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Precision teaching can accelerate basic skills progress of special needs children. Issues discussed include using probes as performance tests, charting daily progress, using the charted data to modify teaching methods, determining appropriate age levels, assessing the number of students to be precision taught, and carefully allocating time. (JDD)

  15. Precision of the CAESAR Scan-Extracted Measurements

    DTIC Science & Technology

    2006-05-01

    left 283.0 26.9 1.8 280.4 57.1 2.7 Elbow height, sitting (comfortable), right 276.8 34.4 2.1 280.3 40.8 2.3 Femoral epicondyle , lateral, left to...height 7 2.4* 0.34 2.9* 0.32 Chest height 11 4.5* 0.49 4.7* 0,65 Elbow height, standing, left 5.2 0.99 6.8 0.69 Elbow height, standing, right 6.9 1.04 7.3...Acromial height, sitting (comfortable), right 9 5.4* 0.73 6.2* 1.24 Bi-lateral femoral epicondyle breadth, sitting 16.6 3.10 17.4 2.85 (comfortable) Bi

  16. Precision optical navigation guidance system

    NASA Astrophysics Data System (ADS)

    Starodubov, D.; McCormick, K.; Nolan, P.; Johnson, D.; Dellosa, M.; Volfson, L.; Fallahpour, A.; Willner, A.

    2016-05-01

    We present the new precision optical navigation guidance system approach that provides continuous, high quality range and bearing data to fixed wing aircraft during landing approach to an aircraft carrier. The system uses infrared optical communications to measure range between ship and aircraft with accuracy and precision better than 1 meter at ranges more than 7.5 km. The innovative receiver design measures bearing from aircraft to ship with accuracy and precision better than 0.5 mRad. The system provides real-time range and bearing updates to multiple aircraft at rates up to several kHz, and duplex data transmission between ship and aircraft.

  17. Origin and history of the Charleston Bump - Geological formations, currents, bottom conditions, and their relationship to wreckfish habitats on the Blake Plateau

    USGS Publications Warehouse

    Popenoe, P.; Manheim, F. T.

    2001-01-01

    The Charleston Bump is a structural and topographic high on the northern Blake Plateau that overlies a seaward offset of the edge of continental crust. The feature causes the bottom to shoal and deflects the Gulf Stream offshore, causing an intensification of bottom currents. The area has been swept by strong currents since late Cretaceous time, but the strongest currents have occurred in the Neogene (last ???25 million years). Nondepositional conditions prevail at present, but erosion of the bottom is checked where the bottom is armored by a hard surficial layer of phosphorite pavement. The phosphorite pavements were formed by re-cementation of eroded residues of phosphorite-rich sediments of early-Neogene age. In some places there are multiple pavements separated by poorly lithified sediments. Submersible observations indicate that the south, or current-facing flank of the Charleston Bump has several deep (>100 m) scour depressions, the southern flanks of which form cliffs characterized by ledges and overhangs. In other areas discrete layers of older Paleogene rocks have been partly eroded away, leaving cliff-like steps of 5 m or more relief. Conglomeratic phosphorite pavement layers up to 1 m thick armor most of the bottom. Where breached by scour, these pavements form both low-relief ledges and rock piles. These features form a reef-like environment of caves and overhangs utilized by wreckfish Polyprion americanus and barrelfish Hyperoglyphe perciformis as shelter from the current and as staging areas to prey on passing schools of squid. Wreckfish and other large fish were often localized in rugged bottom habitat, including caves and other shelter areas. We observed wreckfish darting from shelters to feed on passing schools of squid. Present and past observations, are consistent with the concept that impingement of the Gulf Stream at the Charleston Bump compresses midwater fauna from much thicker water layers, providing food for a flourishing big-fish fauna

  18. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  19. Precision radiotherapy for brain tumors

    PubMed Central

    Yan, Ying; Guo, Zhanwen; Zhang, Haibo; Wang, Ning; Xu, Ying

    2012-01-01

    OBJECTIVE: Precision radiotherapy plays an important role in the management of brain tumors. This study aimed to identify global research trends in precision radiotherapy for brain tumors using a bibliometric analysis of the Web of Science. DATA RETRIEVAL: We performed a bibliometric analysis of data retrievals for precision radiotherapy for brain tumors containing the key words cerebral tumor, brain tumor, intensity-modulated radiotherapy, stereotactic body radiation therapy, stereotactic ablative radiotherapy, imaging-guided radiotherapy, dose-guided radiotherapy, stereotactic brachytherapy, and stereotactic radiotherapy using the Web of Science. SELECTION CRITERIA: Inclusion criteria: (a) peer-reviewed articles on precision radiotherapy for brain tumors which were published and indexed in the Web of Science; (b) type of articles: original research articles and reviews; (c) year of publication: 2002-2011. Exclusion criteria: (a) articles that required manual searching or telephone access; (b) Corrected papers or book chapters. MAIN OUTCOME MEASURES: (1) Annual publication output; (2) distribution according to country; (3) distribution according to institution; (4) top cited publications; (5) distribution according to journals; and (6) comparison of study results on precision radiotherapy for brain tumors. RESULTS: The stereotactic radiotherapy, intensity-modulated radiotherapy, and imaging-guided radiotherapy are three major methods of precision radiotherapy for brain tumors. There were 260 research articles addressing precision radiotherapy for brain tumors found within the Web of Science. The USA published the most papers on precision radiotherapy for brain tumors, followed by Germany and France. European Synchrotron Radiation Facility, German Cancer Research Center and Heidelberg University were the most prolific research institutes for publications on precision radiotherapy for brain tumors. Among the top 13 research institutes publishing in this field, seven

  20. Precision Timed Infrastructure: Design Challenges

    DTIC Science & Technology

    2013-09-19

    recognized the need to precisely model and control time. Mod- elica [30], Simulink [28], and Ptolemy II [12] can precisely model time in both physical and...languages have different ways of expressing computations and timing constraints [5]. For instance, Mod- elica [30], Simulink [28], Giotto [17], Ptolemy ...Languages Intermediate Languages Assembly Languages Modelica Ptolemy IIGiotto and E machine Modelyze PRET Compilation Hide machine dependent details

  1. Precision GPS ephemerides and baselines

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Based on the research, the area of precise ephemerides for GPS satellites, the following observations can be made pertaining to the status and future work needed regarding orbit accuracy. There are several aspects which need to be addressed in discussing determination of precise orbits, such as force models, kinematic models, measurement models, data reduction/estimation methods, etc. Although each one of these aspects was studied at CSR in research efforts, only points pertaining to the force modeling aspect are addressed.

  2. Fundamental Physics and Precision Measurements

    NASA Astrophysics Data System (ADS)

    Hänsch, T. W.

    2006-11-01

    "Very high precision physics has always appealed to me. The steady improvement in technologies that afford higher and higher precision has been a regular source of excitement and challenge during my career. In science, as in most things, whenever one looks at something more closely, new aspects almost always come into play …" With these word from the book "How the Laser happened", Charles H. Townes expresses a passion for precision that is now shared by many scientists. Masers and lasers have become indispensible tools for precision measurements. During the past few years, the advent of femtosecond laser frequency comb synthesizers has revolutionized the art of directly comparing optical and microwave frequencies. Inspired by the needs of precision laser spectroscopy of the simple hydrogen atom, such frequency combs are now enabling ultra-precise spectroscopy over wide spectral ranges. Recent laboratory experiments are already setting stringent limits for possible slow variations of fundamental constants. Laser frequency combs also provide the long missing clockwork for optical atomic clocks that may ultimately reach a precision of parts in 1018 and beyond. Such tools will open intriguing new opportunities for fundamental experiments including new tests of special and general relativity. In the future, frequency comb techniques may be extended into the extreme ultraviolet and soft xray regime, opening a vast new spectral territory to precision measurements. Frequency combs have also become a key tool for the emerging new field of attosecond science, since they can control the electric field of ultrashort laser pulses on an unprecedented time scale. The biggest surprise in these endeavours would be if we found no surprise.

  3. High-precision opto-mechanical lens system for space applications assembled by innovative local soldering technique

    NASA Astrophysics Data System (ADS)

    Ribes, P.; Koechlin, C.; Burkhardt, T.; Hornaff, M.; Burkhardt, D.; Kamm, A.; Gramens, S.; Beckert, E.; Fiault, G.; Eberhardt, R.; Tünnermann, A.

    2016-02-01

    Solder joining using metallic solder alloys is an alternative to adhesive bonding. Laser-based soldering processes are especially well suited for the joining of optical components made of fragile and brittle materials such as glasses, ceramics and optical crystals. This is due to a localized and minimized input of thermal energy. Solderjet bumping technology has been used to assemble a lens mount breadboard taking as input specifications the requirements found for the optical beam expander for the European Space Agency (ESA) EarthCare Mission. The silica lens and a titanium barrel have been designed and assembled with this technology in order to withstand the stringent mission demands; handling high mechanical and thermal loads without losing its optical performances. Finally a high-precision opto-mechanical lens mount has been assembled with a minimal localized stress (<1 MPa) showing outstanding performances in terms of wave-front error measurements and beam depolarization ratio before and after environmental tests.

  4. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition

    PubMed Central

    2015-01-01

    We describe new synthetic routes developed toward a range of substituted analogues of bromo and extra-terminal (BET) bromodomain inhibitors I-BET762/JQ1 based on the triazolo-benzodiazepine scaffold. These new routes allow for the derivatization of the methoxyphenyl and chlorophenyl rings, in addition to the diazepine ternary center and the side chain methylene moiety. Substitution at the level of the side chain methylene afforded compounds targeting specifically and potently engineered BET bromodomains designed as part of a bump and hole approach. We further demonstrate that marked selectivity for the second over the first bromodomain can be achieved with an indole derivative that exploits differential interaction with an aspartate/histidine conservative substitution on the BC loop of BET bromodomains. PMID:26367539

  5. LATE TIME MULTI-WAVELENGTH OBSERVATIONS OF SWIFT J1644+5734: A LUMINOUS OPTICAL/IR BUMP AND QUIESCENT X-RAY EMISSION

    SciTech Connect

    Levan, A. J.; Brown, G. C.; Lyman, J. D.; Stanway, E. R.; Tanvir, N. R.; Page, K. L.; O’Brien, P. T.; Wiersema, K.; Metzger, B. D.; Cenko, S. B.; Fruchter, A. S.; Perley, D. A.; Bloom, J. S.

    2016-03-01

    We present late time multi-wavelength observations of Swift J1644+57, suggested to be a relativistic tidal disruption flare (TDF). Our observations extend to >4 years from discovery and show that 1.4 years after outburst the relativistic jet switched off on a timescale less than tens of days, corresponding to a power-law decay faster than t{sup −70}. Beyond this point weak X-rays continue to be detected at an approximately constant luminosity of L{sub X} ∼ 5 × 10{sup 42} erg s{sup −1} and are marginally inconsistent with a continuing decay of t{sup −5/3}, similar to that seen prior to the switch-off. Host photometry enables us to infer a black hole mass of M{sub BH} = 3 × 10{sup 6} M{sub ⊙}, consistent with the late time X-ray luminosity arising from sub-Eddington accretion onto the black hole in the form of either an unusually optically faint active galactic nucleus or a slowly varying phase of the transient. Optical/IR observations show a clear bump in the light curve at timescales of 30–50 days, with a peak magnitude (corrected for host galaxy extinction) of M{sub R} ∼ −22 to −23. The luminosity of the bump is significantly higher than seen in other, non-relativistic TDFs and does not match any re-brightening seen at X-ray or radio wavelengths. Its luminosity, light curve shape, and spectrum are broadly similar to those seen in superluminous supervnovae, although subject to large uncertainties in the correction of the significant host extinction. We discuss these observations in the context of both TDF and massive star origins for Swift J1644+5734 and other candidate relativistic tidal flares.

  6. Chip to Chip Bonding Using Cu Bumps Capped with Thin Sn Layers and the Effect of Microstructure on the Shear Strength of Joints

    NASA Astrophysics Data System (ADS)

    Kim, Yang Ho; Ma, Sung Woo; Kim, Young-Ho

    2014-09-01

    Chip to chip bonding techniques using Cu bumps capped with thin solder layers have been frequently applied to 3D chip stacking technology. We studied the effect of joint microstructure on shear strength. Joints were formed by joining Sn/Cu bumps on a Si die and Sn/Cu layers on another Si die at 245-330°C using a thermo-compression bonder. Three different types of microstructures were fabricated in the joints by controlling the bonding temperature and time, (1) a Sn-rich phase with a Cu6Sn5 phase at the Cu interfaces, (2) a Cu6Sn5 phase in the interior with a Cu3Sn phase at the Cu interfaces, and (3) one single Cu3Sn phase throughout the whole joint. The joint having a single Cu3Sn phase had the highest shear strength. Specimens were aged up to 2000 h at 150°C and 180°C. During aging, the microstructures of all joints were transformed in a single Cu3Sn phase. The shear strength of the joints was very sensitive to the formation of Cu3Sn and microvoids. Microvoids formed in the solder joints with a Cu6Sn5 phase with and without a Sn-rich phase during aging and decreased the shear strength of the joints. Conversely, aging did not induce the formation of microvoids in the joints which originally had only a Cu3Sn phase and the shear strength was not decreased.

  7. Late Time Multi-wavelength Observations of Swift J1644+5734: A Luminous Optical/IR Bump and Quiescent X-Ray Emission

    NASA Astrophysics Data System (ADS)

    Levan, A. J.; Tanvir, N. R.; Brown, G. C.; Metzger, B. D.; Page, K. L.; Cenko, S. B.; O'Brien, P. T.; Lyman, J. D.; Wiersema, K.; Stanway, E. R.; Fruchter, A. S.; Perley, D. A.; Bloom, J. S.

    2016-03-01

    We present late time multi-wavelength observations of Swift J1644+57, suggested to be a relativistic tidal disruption flare (TDF). Our observations extend to >4 years from discovery and show that 1.4 years after outburst the relativistic jet switched off on a timescale less than tens of days, corresponding to a power-law decay faster than t-70. Beyond this point weak X-rays continue to be detected at an approximately constant luminosity of LX ˜ 5 × 1042 erg s-1 and are marginally inconsistent with a continuing decay of t-5/3, similar to that seen prior to the switch-off. Host photometry enables us to infer a black hole mass of MBH = 3 × 106 M⊙, consistent with the late time X-ray luminosity arising from sub-Eddington accretion onto the black hole in the form of either an unusually optically faint active galactic nucleus or a slowly varying phase of the transient. Optical/IR observations show a clear bump in the light curve at timescales of 30-50 days, with a peak magnitude (corrected for host galaxy extinction) of MR ˜ -22 to -23. The luminosity of the bump is significantly higher than seen in other, non-relativistic TDFs and does not match any re-brightening seen at X-ray or radio wavelengths. Its luminosity, light curve shape, and spectrum are broadly similar to those seen in superluminous supervnovae, although subject to large uncertainties in the correction of the significant host extinction. We discuss these observations in the context of both TDF and massive star origins for Swift J1644+5734 and other candidate relativistic tidal flares.

  8. Precise Near-Infrared Radial Velocities

    NASA Astrophysics Data System (ADS)

    Plavchan, Peter; Gao, P.; Bottom, M.; Davison, C.; Mills, S.; Ciardi, D. R.; Brinkworth, C.; Tanner, A. M.; Beichman, C. A.; Catanzarite, J.; Crawford, S.; Wallace, J.; Mennesson, B.; Johnson, J. A.; White, R. J.; Anglada-Escudé, G.; von Braun, K.; Walp, B.; Vasisht, G.; Kane, S. R.; Prato, L. A.; NIRRVs

    2014-01-01

    We present precise radial velocity time-series from a 2.3 micron pilot survey to detect exoplanets around red, low mass, and young stars. We use the CSHELL spectrograph with an isotopic methane absorption gas cell for common optical path relative wavelength calibration at the NASA InfraRed Telescope Facility. We present an overview of our Nelder-Mead simplex optimization pipeline for extracting radial velocities. We will also present first light data at 1.6 microns from a near-infrared fiber scrambler used in tandem with our gas cell and CSHELL at IRTF. The fiber scrambler makes use of non-circular core fibers to stabilize the illumination of the slit and echelle grating against changes in seeing, focus, guiding and other sources of systematic radial velocity noise, complementing the wavelength calibration of a gas cell.

  9. Precision atomic gravimeter based on Bragg diffraction

    NASA Astrophysics Data System (ADS)

    Altin, P. A.; Johnsson, M. T.; Negnevitsky, V.; Dennis, G. R.; Anderson, R. P.; Debs, J. E.; Szigeti, S. S.; Hardman, K. S.; Bennetts, S.; McDonald, G. D.; Turner, L. D.; Close, J. D.; Robins, N. P.

    2013-02-01

    We present a precision gravimeter based on coherent Bragg diffraction of freely falling cold atoms. Traditionally, atomic gravimeters have used stimulated Raman transitions to separate clouds in momentum space by driving transitions between two internal atomic states. Bragg interferometers utilize only a single internal state, and can therefore be less susceptible to environmental perturbations. Here we show that atoms extracted from a magneto-optical trap using an accelerating optical lattice are a suitable source for a Bragg atom interferometer, allowing efficient beamsplitting and subsequent separation of momentum states for detection. Despite the inherently multi-state nature of atom diffraction, we are able to build a Mach-Zehnder interferometer using Bragg scattering which achieves a sensitivity to the gravitational acceleration of Δg/g = 2.7 × 10-9 with an integration time of 1000 s. The device can also be converted to a gravity gradiometer by a simple modification of the light pulse sequence.

  10. High Precision Photometry for the K2 Mission

    NASA Astrophysics Data System (ADS)

    Huang, Xu; Soares-Furtado, Melinda; Penev, Kaloyan; Hartman, Joel; Bakos, Gaspar; Bhatti, Waqas; Domsa, Istvan; de Val-Borro, Miguel

    2015-12-01

    The two reaction wheel K2 mission brings new challenges for the data reduction processes. We developed a reduction pipeline for extracting high precision photometry from the K2 dataset and we use this pipeline to generate light curves for the K2 Campaign 0 super-stamps and K2 Campaign 1 target pixel dataset. Key to our reduction technique is the derivation of global astrometric solutions from the target stamps from which accurate centroids are passed on for high precision photometry extraction. We also implemented the image subtraction method to reduce the K2 Campaign 0 super-stamps containing open clusters M35 and NGC2158. We extract target light curvesfor sources from a combined UCAC4 and EPIC catalogue -- this includes not only primary targets of the K2 Mission, but also other stars that happen to fall on the pixel stamps. Our astrometric solutions achieve a median residual of ~0.127". For bright stars, our best 6.5 hour precision for raw light curves is ~20 parts per million (ppm). For our detrended light curves, the best 6.5 hour precision achieved is ~15 ppm. We show that our detrended light curves have fewer systematic effects (or trends, or red-noise) than light curves produced by other groups from the same observations. We highlight the measurements of rotation curves using the K2 light curves of stars within open cluster M35 and NGC2158.

  11. Precise Orbit Determination for ALOS

    NASA Technical Reports Server (NTRS)

    Nakamura, Ryo; Nakamura, Shinichi; Kudo, Nobuo; Katagiri, Seiji

    2007-01-01

    The Advanced Land Observing Satellite (ALOS) has been developed to contribute to the fields of mapping, precise regional land coverage observation, disaster monitoring, and resource surveying. Because the mounted sensors need high geometrical accuracy, precise orbit determination for ALOS is essential for satisfying the mission objectives. So ALOS mounts a GPS receiver and a Laser Reflector (LR) for Satellite Laser Ranging (SLR). This paper deals with the precise orbit determination experiments for ALOS using Global and High Accuracy Trajectory determination System (GUTS) and the evaluation of the orbit determination accuracy by SLR data. The results show that, even though the GPS receiver loses lock of GPS signals more frequently than expected, GPS-based orbit is consistent with SLR-based orbit. And considering the 1 sigma error, orbit determination accuracy of a few decimeters (peak-to-peak) was achieved.

  12. Precision cleaning apparatus and method

    DOEpatents

    Schneider, T.W.; Frye, G.C.; Martin, S.J.

    1998-01-13

    A precision cleaning apparatus and method are disclosed. The precision cleaning apparatus includes a cleaning monitor further comprising an acoustic wave cleaning sensor such as a quartz crystal microbalance (QCM), a flexural plate wave (FPW) sensor, a shear horizontal acoustic plate mode (SH--APM) sensor, or a shear horizontal surface acoustic wave (SH--SAW) sensor; and measurement means connectable to the sensor for measuring in-situ one or more electrical response characteristics that vary in response to removal of one or more contaminants from the sensor and a workpiece located adjacent to the sensor during cleaning. Methods are disclosed for precision cleaning of one or more contaminants from a surface of the workpiece by means of the cleaning monitor that determines a state of cleanliness and any residual contamination that may be present after cleaning; and also for determining an effectiveness of a cleaning medium for removing one or more contaminants from a workpiece. 11 figs.

  13. Precision cleaning apparatus and method

    DOEpatents

    Schneider, Thomas W.; Frye, Gregory C.; Martin, Stephen J.

    1998-01-01

    A precision cleaning apparatus and method. The precision cleaning apparatus includes a cleaning monitor further comprising an acoustic wave cleaning sensor such as a quartz crystal microbalance (QCM), a flexural plate wave (FPW) sensor, a shear horizontal acoustic plate mode (SH--APM) sensor, or a shear horizontal surface acoustic wave (SH--SAW) sensor; and measurement means connectable to the sensor for measuring in-situ one or more electrical response characteristics that vary in response to removal of one or more contaminants from the sensor and a workpiece located adjacent to the sensor during cleaning. Methods are disclosed for precision cleaning of one or more contaminants from a surface of the workpiece by means of the cleaning monitor that determines a state of cleanliness and any residual contamination that may be present after cleaning; and also for determining an effectiveness of a cleaning medium for removing one or more contaminants from a workpiece.

  14. A precision mechanical nerve stimulator

    NASA Technical Reports Server (NTRS)

    Tcheng, Ping; Supplee, Frank H., Jr.; Prass, Richard L.

    1988-01-01

    An electromechanical device, used to apply and monitor stimulating pulses to a mammalian motor nerve, has been successfully developed at NASA Langley Research Center. Two existing force transducers, a flight skin friction balance and a miniature skin friction balance which were designed for making aerodynamic drag measurements, were modified and incorporated to form this precision instrument. The nerve stimulator is a type one servomechanism capable of applying and monitoring stimulating pulses of 0 to 10 grams with a precision of better than +/- 0.05 grams. Additionally, the device can be independently used to apply stimulating pulses by displacing the nerve from 0 to 0.25 mm with a precision of better than +/- 0.001 mm while measuring the level of the load applied.

  15. Precision-guaranteed quantum metrology

    NASA Astrophysics Data System (ADS)

    Sugiyama, Takanori

    2015-04-01

    Quantum metrology is a general term for methods to precisely estimate the value of an unknown parameter by actively using quantum resources. In particular, some classes of entangled states can be used to significantly suppress the estimation error. Here we derive a formula for rigorously evaluating an upper bound for the estimation error in a general setting of quantum metrology with arbitrary finite data sets. Unlike in the standard approach, where lower bounds for the error are evaluated in an ideal setting with almost infinite data, our method rigorously guarantees the estimation precision in realistic settings with finite data. We also prove that our upper bound shows the Heisenberg limit scaling whenever the linearized uncertainty, which is a popular benchmark in the standard approach, shows it. As an example, we apply our result to a Ramsey interferometer, and numerically show that the upper bound can exhibit the quantum enhancement of precision for finite data.

  16. Kinematic precision of gear trains

    NASA Technical Reports Server (NTRS)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1982-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory.

  17. Kinematic precision of gear trains

    NASA Technical Reports Server (NTRS)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1983-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory. Previously announced in STAR as N82-32733

  18. Precision Multiband Photometry with a DSLR Camera

    NASA Astrophysics Data System (ADS)

    Zhang, M.; Bakos, G. Á.; Penev, K.; Csubry, Z.; Hartman, J. D.; Bhatti, W.; de Val-Borro, M.

    2016-03-01

    Ground-based exoplanet surveys such as SuperWASP, HAT Network of Telescopes (HATNet), and KELT have discovered close to two hundred transiting extrasolar planets in the past several years. The strategy of these surveys is to look at a large field of view and measure the brightnesses of its bright stars to around half a percent per point precision, which is adequate for detecting hot Jupiters. Typically, these surveys use CCD detectors to achieve high precision photometry. These CCDS, however, are expensive relative to other consumer-grade optical imaging devices, such as digital single-lens reflex cameras (DSLRs). We look at the possibility of using a DSLR camera for precision photometry. Specifically, we used a Canon EOS 60D camera that records light in three colors simultaneously. The DSLR was integrated into the HATNet survey and collected observations for a month, after which photometry was extracted for 6600 stars in a selected stellar field. We found that the DSLR achieves a best-case median absolute deviation of 4.6 mmag per 180 s exposure when the DSLR color channels are combined, and 1000 stars are measured to better than 10 mmag (1%). Also, we achieve 10 mmag or better photometry in the individual colors. This is good enough to detect transiting hot Jupiters. We performed a candidate search on all stars and found four candidates, one of which is KELT-3b, the only known transiting hot Jupiter in our selected field. We conclude that the Canon 60D is a cheap, lightweight device capable of useful photometry in multiple colors.

  19. Precision processing of earth image data

    NASA Technical Reports Server (NTRS)

    Bernstein, R.; Stierhoff, G. C.

    1976-01-01

    Precise corrections of Landsat data are useful for generating land-use maps, detecting various crops and determining their acreage, and detecting changes. The paper discusses computer processing and visualization techniques for Landsat data so that users can get more information from the imagery. The elementary unit of data in each band of each scene is the integrated value of intensity of reflected light detected in the field of view by each sensor. To develop the basic mathematical approach for precision correction of the data, differences between positions of ground control points on the reference map and the observed control points in the scene are used to evaluate the coefficients of cubic time functions of roll, pitch, and yaw, and a linear time function of altitude deviation from normal height above local earth's surface. The resultant equation, termed a mapping function, corrects the warped data image into one that approximates the reference map. Applications are discussed relative to shade prints, extraction of road features, and atlas of cities.

  20. Precision protection through indirect correlations

    SciTech Connect

    Jin, Yao

    2016-04-15

    The dynamics of the quantum Fisher information of the parameters of the initial atomic state is studied, in the framework of open quantum systems, for a pair of static two-level atoms coupled to a bath of fluctuating vacuum scalar fields. Our results show that the correlations between the two atoms as well as the precision limit in quantum metrology are determined by the separation between the two atoms. Remarkably, when the separation between the two atoms approaches zero, the quantum Fisher information, thus the precision limit of the estimation of the parameters of the initial atomic state will be survived from the vacuum fluctuations after long time evolution.

  1. Precision Manipulation with Cooperative Robots

    NASA Technical Reports Server (NTRS)

    Stroupe, Ashley; Huntsberger, Terry; Okon, Avi; Aghzarian, Hrand

    2005-01-01

    This work addresses several challenges of cooperative transportThis work addresses several challenges of cooperative transport and precision manipulation. Precision manipulation requires a rigid grasp, which places a hard constraint on the relative rover formation that must be accommodated, even though the rovers cannot directly observe their relative poses. Additionally, rovers must jointly select appropriate actions based on all available sensor information. Lastly, rovers cannot act on independent sensor information, but must fuse information to move jointly; the methods for fusing information must be determined.

  2. Microbiopsy/precision cutting devices

    DOEpatents

    Krulevitch, Peter A.; Lee, Abraham P.; Northrup, M. Allen; Benett, William J.

    1999-01-01

    Devices for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways 1) intravascularly, 2) extravascularly, 3) by vessel puncture, and 4) externally. Additionally, the devices may be used in precision surgical cutting.

  3. Microbiopsy/precision cutting devices

    DOEpatents

    Krulevitch, P.A.; Lee, A.P.; Northrup, M.A.; Benett, W.J.

    1999-07-27

    Devices are disclosed for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways (1) intravascularly, (2) extravascularly, (3) by vessel puncture, and (4) externally. Additionally, the devices may be used in precision surgical cutting. 6 figs.

  4. PRECISION RADIAL VELOCITIES WITH CSHELL

    SciTech Connect

    Crockett, Christopher J.; Prato, L.; Mahmud, Naved I.; Johns-Krull, Christopher M.; Jaffe, Daniel T.; Beichman, Charles A. E-mail: lprato@lowell.edu E-mail: cmj@rice.edu

    2011-07-10

    Radial velocity (RV) identification of extrasolar planets has historically been dominated by optical surveys. Interest in expanding exoplanet searches to M dwarfs and young stars, however, has motivated a push to improve the precision of near-infrared RV techniques. We present our methodology for achieving 58 m s{sup -1} precision in the K band on the M0 dwarf GJ 281 using the CSHELL spectrograph at the 3 m NASA Infrared Telescope Facility. We also demonstrate our ability to recover the known 4 M{sub JUP} exoplanet Gl 86 b and discuss the implications for success in detecting planets around 1-3 Myr old T Tauri stars.

  5. Precision agriculture and food security.

    PubMed

    Gebbers, Robin; Adamchuk, Viacheslav I

    2010-02-12

    Precision agriculture comprises a set of technologies that combines sensors, information systems, enhanced machinery, and informed management to optimize production by accounting for variability and uncertainties within agricultural systems. Adapting production inputs site-specifically within a field and individually for each animal allows better use of resources to maintain the quality of the environment while improving the sustainability of the food supply. Precision agriculture provides a means to monitor the food production chain and manage both the quantity and quality of agricultural produce.

  6. Sensor fusion for precision agriculture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Information-based management of crop production systems known as precision agriculture relies on different sensor technologies aimed at characterization of spatial heterogeneity of a cropping environment. Remote and proximal sensing systems have been deployed to obtain high-resolution data pertainin...

  7. Drilling Precise Orifices and Slots

    NASA Technical Reports Server (NTRS)

    Richards, C. W.; Seidler, J. E.

    1983-01-01

    Reaction control thrustor injector requires precisely machined orifices and slots. Tooling setup consists of rotary table, numerical control system and torque sensitive drill press. Components used to drill oxidizer orifices. Electric discharge machine drills fuel-feed orifices. Device automates production of identical parts so several are completed in less time than previously.

  8. Precision Teaching ... and All That!

    ERIC Educational Resources Information Center

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Two proponents of the precision teaching approach to teaching the handicapped discuss such principles as: the problem of partial application of the method; relationship to behaviorism; relationship to experiential learning; and the importance of fluency in task performance, mastery learning, and recordkeeping. (DB)

  9. Precision Machining Technology. Curriculum Guide.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This curriculum guide was developed from a Technical Committee Report prepared with the assistance of industry personnel and containing a Task List which is the basis of the guide. It presents competency-based program standards for courses in precision machining technology and is part of the Idaho Vocational Curriculum Guide Project, a cooperative…

  10. Precision GPS ephemerides and baselines

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The emphasis of this grant was focused on precision ephemerides for the Global Positioning System (GPS) satellites for geodynamics applications. During the period of this grant, major activities were in the areas of thermal force modeling, numerical integration accuracy improvement for eclipsing satellites, analysis of GIG '91 campaign data, and the Southwest Pacific campaign data analysis.

  11. Cushing's disease: towards precision medicine.

    PubMed

    Kaiser, Ursula B

    2015-06-01

    The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.

  12. Precision Efficacy Analysis for Regression.

    ERIC Educational Resources Information Center

    Brooks, Gordon P.

    When multiple linear regression is used to develop a prediction model, sample size must be large enough to ensure stable coefficients. If the derivation sample size is inadequate, the model may not predict well for future subjects. The precision efficacy analysis for regression (PEAR) method uses a cross- validity approach to select sample sizes…

  13. Precision Cleaning - Path to Premier

    NASA Technical Reports Server (NTRS)

    Mackler, Scott E.

    2008-01-01

    ITT Space Systems Division s new Precision Cleaning facility provides critical cleaning and packaging of aerospace flight hardware and optical payloads to meet customer performance requirements. The Precision Cleaning Path to Premier Project was a 2007 capital project and is a key element in the approved Premier Resource Management - Integrated Supply Chain Footprint Optimization Project. Formerly precision cleaning was located offsite in a leased building. A new facility equipped with modern precision cleaning equipment including advanced process analytical technology and improved capabilities was designed and built after outsourcing solutions were investigated and found lacking in ability to meet quality specifications and schedule needs. SSD cleans parts that can range in size from a single threaded fastener all the way up to large composite structures. Materials that can be processed include optics, composites, metals and various high performance coatings. We are required to provide verification to our customers that we have met their particulate and molecular cleanliness requirements and we have that analytical capability in this new facility. The new facility footprint is approximately half the size of the former leased operation and provides double the amount of throughput. Process improvements and new cleaning equipment are projected to increase 1st pass yield from 78% to 98% avoiding $300K+/yr in rework costs. Cost avoidance of $350K/yr will result from elimination of rent, IT services, transportation, and decreased utility costs. Savings due to reduced staff expected to net $4-500K/yr.

  14. 76 FR 35024 - Precision Dynamics Corporation San Fernando, CA; Precision Dynamics Corporation, Also Known as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Employment and Training Administration Precision Dynamics Corporation San Fernando, CA; Precision Dynamics... for Worker Adjustment Assistance on January 28, 2011, applicable to workers of Precision Dynamics... the subject firm. The Valencia, California location of Precision Dynamics Corporation, also known...

  15. Beyond precision surgery: Molecularly motivated precision care for gastric cancer.

    PubMed

    Choi, Y Y; Cheong, J-H

    2017-03-01

    Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite the high disease prevalence, gastric cancer research has not gained much attention. Recently, genome-scale technology has made it possible to explore the characteristics of gastric cancer at the molecular level. Accordingly, gastric cancer can be classified into molecular subtypes that convey more detailed information of tumor than histopathological characteristics, and these subtypes are associated with clinical outcomes. Furthermore, this molecular knowledge helps to identify new actionable targets and develop novel therapeutic strategies. To advance the concept of precision patient care in the clinic, patient-derived xenograft (PDX) models have recently been developed. PDX models not only represent histology and genomic features, but also predict responsiveness to investigational drugs in patient tumors. Molecularly curated PDX cohorts will be instrumental in hypothesis generation, biomarker discovery, and drug screening and testing in proof-of-concept preclinical trials for precision therapy. In the era of precision medicine, molecularly tailored therapeutic strategies should be individualized for cancer patients. To improve the overall clinical outcome, a multimodal approach is indispensable for advanced cancer patients. Careful, oncological principle-based surgery, combined with a molecularly guided multidisciplinary approach, will open new horizons in surgical oncology.

  16. Precision Rosenbluth measurement of the proton elastic form factors

    SciTech Connect

    I. A. Qattan; J. Arrington; R. E. Segel; X. Zheng; K. Aniol; O. K. Baker; R. Beams; E. J. Brash; J. Calarco; A. Camsonne; J.-P. Chen; M. E. Christy; D. Dutta; R. Ent; S. Frullani; D. Gaskell; O. Gayou; R. Gilman; C. Glashausser; K. Hafidi; J.-O. Hansen; D. W. Higinbotham; W. Hinton; R. J. Holt; G. M. Huber; H. Ibrahim; L. Jisonna; M. K. Jones; C. E. Keppel; E. Kinney; G. J. Kumbartzki; A. Lung; D. J. Margaziotis; K. McCormick; D. Meekins; R. Michaels; P. Monaghan; P. Moussiegt; L. Pentchev; C. Perdrisat; V. Punjabi; R. Ransome; J. Reinhold; B. Reitz; A. Saha; A. Sarty; E. C. Schulte; K. Slifer; P. Solvignon; V. Sulkosky; K. Wijesooriya; B. Zeidman

    2004-10-01

    We report the results of a new Rosenbluth measurement of the proton form factors at Q{sup 2} values of 2.64, 3.20 and 4.10 GeV{sup 2}. Cross sections were determined by detecting the recoiling proton in contrast to previous measurements in which the scattered electron was detected. At each Q{sup 2}, relative cross sections were determined to better than 1%. The measurement focused on the extraction of G{sub E}/G{sub M} which was determined to 4-8% and found to approximate form factor scaling, i.e. {mu}{sub p}G{sub E} {approx} G{sub M}. These results are consistent with and much more precise than previous Rosenbluth extractions. However, they are inconsistent with recent polarization transfer measurements of comparable precision, implying a systematic difference between the two techniques.

  17. Green Solvents for Precision Cleaning

    NASA Technical Reports Server (NTRS)

    Grandelli, Heather; Maloney, Phillip; DeVor, Robert; Surma, Jan; Hintze, Paul

    2013-01-01

    Aerospace machinery used in liquid oxygen (LOX) fuel systems must be precision cleaned to achieve a very low level of non-volatile residue (< 1 mg0.1 m2), especially flammable residue. Traditionally chlorofluorocarbons (CFCs) have been used in the precision cleaning of LOX systems, specifically CFC 113 (C2Cl3F3). CFCs have been known to cause the depletion of ozone and in 1987, were banned by the Montreal Protocol due to health, safety and environmental concerns. This has now led to the development of new processes in the precision cleaning of aerospace components. An ideal solvent-replacement is non-flammable, environmentally benign, non-corrosive, inexpensive, effective and evaporates completely, leaving no residue. Highlighted is a green precision cleaning process, which is contaminant removal using supercritical carbon dioxide as the environmentally benign solvent. In this process, the contaminant is dissolved in carbon dioxide, and the parts are recovered at the end of the cleaning process completely dry and ready for use. Typical contaminants of aerospace components include hydrocarbon greases, hydraulic fluids, silicone fluids and greases, fluorocarbon fluids and greases and fingerprint oil. Metallic aerospace components range from small nuts and bolts to much larger parts, such as butterfly valves 18 in diameter. A fluorinated grease, Krytox, is investigated as a model contaminant in these preliminary studies, and aluminum coupons are employed as a model aerospace component. Preliminary studies are presented in which the experimental parameters are optimized for removal of Krytox from aluminum coupons in a stirred-batch process. The experimental conditions investigated are temperature, pressure, exposure time and impeller speed. Temperatures of 308 - 423 K, pressures in the range of 8.3 - 41.4 MPa, exposure times between 5 - 60 min and impeller speeds of 0 - 1000 rpm were investigated. Preliminary results showed up to 86 cleaning efficiency with the

  18. Method for grinding precision components

    DOEpatents

    Ramanath, Srinivasan; Kuo, Shih Yee; Williston, William H.; Buljan, Sergej-Tomislav

    2000-01-01

    A method for precision cylindrical grinding of hard brittle materials, such as ceramics or glass and composites comprising ceramics or glass, provides material removal rates as high as 19-380 cm.sup.3 /min/cm. The abrasive tools used in the method comprise a strong, light weight wheel core bonded to a continuous rim of abrasive segments containing superabrasive grain in a dense metal bond matrix.

  19. Method for grinding precision components

    SciTech Connect

    Ramanath, S.; Kuo, S.Y.; Williston, W.H.; Buljan, S.T.

    2000-02-01

    A method for precision cylindrical grinding of hard brittle materials, such as ceramics or glass and composites comprising ceramics or glass, provides material removal rates as high as 19--380 cm{sup 3}/min/cm. The abrasive tools used in the method comprise a strong, light weight wheel core bonded to a continuous rim of abrasive segments containing superabrasive grain in a dense metal bond matrix.

  20. Precision linear ramp function generator

    DOEpatents

    Jatko, W.B.; McNeilly, D.R.; Thacker, L.H.

    1984-08-01

    A ramp function generator is provided which produces a precise linear ramp function which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  1. High precision triangular waveform generator

    DOEpatents

    Mueller, Theodore R.

    1983-01-01

    An ultra-linear ramp generator having separately programmable ascending and descending ramp rates and voltages is provided. Two constant current sources provide the ramp through an integrator. Switching of the current at current source inputs rather than at the integrator input eliminates switching transients and contributes to the waveform precision. The triangular waveforms produced by the waveform generator are characterized by accurate reproduction and low drift over periods of several hours. The ascending and descending slopes are independently selectable.

  2. Precision linear ramp function generator

    DOEpatents

    Jatko, W. Bruce; McNeilly, David R.; Thacker, Louis H.

    1986-01-01

    A ramp function generator is provided which produces a precise linear ramp unction which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  3. Precision optical metrology without lasers

    NASA Astrophysics Data System (ADS)

    Bergmann, Ralf B.; Burke, Jan; Falldorf, Claas

    2015-07-01

    Optical metrology is a key technique when it comes to precise and fast measurement with a resolution down to the micrometer or even nanometer regime. The choice of a particular optical metrology technique and the quality of results depends on sample parameters such as size, geometry and surface roughness as well as user requirements such as resolution, measurement time and robustness. Interferometry-based techniques are well known for their low measurement uncertainty in the nm range, but usually require careful isolation against vibration and a laser source that often needs shielding for reasons of eye-safety. In this paper, we concentrate on high precision optical metrology without lasers by using the gradient based measurement technique of deflectometry and the finite difference based technique of shear interferometry. Careful calibration of deflectometry systems allows one to investigate virtually all kinds of reflecting surfaces including aspheres or free-form surfaces with measurement uncertainties below the μm level. Computational Shear Interferometry (CoSI) allows us to combine interferometric accuracy and the possibility to use cheap and eye-safe low-brilliance light sources such as e.g. fiber coupled LEDs or even liquid crystal displays. We use CoSI e.g. for quantitative phase contrast imaging in microscopy. We highlight the advantages of both methods, discuss their transfer functions and present results on the precision of both techniques.

  4. Do not let precision medicine be kidnapped.

    PubMed

    Yang, Zhiping

    2015-12-01

    Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

  5. Precision radiometric surface temperature (PRST) sensor

    NASA Astrophysics Data System (ADS)

    Daly, James T.; Roberts, Carson; Bodkin, Andrew; Sundberg, Robert; Beaven, Scott; Weinheimer, Jeffrey

    2013-05-01

    There is a need for a Precision Radiometric Surface Temperature (PRST) measurement capability that can achieve noncontact profiling of a sample's surface temperature when heated dynamically during laser processing, aerothermal heating or metal cutting/machining. Target surface temperature maps within and near the heated spot provide critical quantitative diagnostic data for laser-target coupling effectiveness and laser damage assessment. In the case of metal cutting, this type of measurement provides information on plastic deformation in the primary shear zone where the cutting tool is in contact with the workpiece. The challenge in these cases is to measure the temperature of a target while its surface's temperature and emissivity are changing rapidly and with incomplete knowledge of how the emissivity and surface texture (scattering) changes with temperature. Bodkin Design and Engineering, LLC (BDandE), with partners Spectral Sciences, Inc. (SSI) and Space Computer Corporation (SCC), has developed a PRST Sensor that is based on a hyperspectral MWIR imager spanning the wavelength range 2-5 μm and providing a hyperspectral datacube of 20-24 wavelengths at 60 Hz frame rate or faster. This imager is integrated with software and algorithms to extract surface temperature from radiometric measurements over the range from ambient to 2000K with a precision of 20K, even without a priori knowledge of the target's emissivity and even as the target emissivity may be changing with time and temperature. In this paper, we will present a description of the PRST system as well as laser heating test results which show the PRST system mapping target surface temperatures in the range 600-2600K on a variety of materials.

  6. In situ heating transmission electron microscopy observation of nanoeutectic lamellar structure in Sn-Ag-Cu alloy on Au under-bump metallization.

    PubMed

    Seo, Jong-Hyun; Yoon, Sang-Won; Kim, Kyou-Hyun; Chang, Hye-Jung; Lee, Kon-Bae; Seong, Tae-Yeon; Fleury, Eric; Ahn, Jae-Pyoung

    2013-08-01

    We investigated the microstructural evolution of Sn(96.4)Ag(2.8)Cu(0.8) solder through in situ heating transmission electron microscopy observations. As-soldered bump consisted of seven layers, containing the nanoeutectic lamella structure of AuSn and Au₅Sn phases, and the polygonal grains of AuSn₂ and AuSn₄, on Au-plated Cu bond pads. Here, we found that there are two nanoeutectic lamellar layers with lamella spacing of 40 and 250 nm. By in situ heating above 140°C, the nanoeutectic lamella of AuSn and Au₅Sn was decomposed with structural degradation by sphering and coarsening processes of the lamellar interface. At the third layer neighboring to the lamella layer, on the other hand, Au₅Sn particles with a zig-zag shape in AuSn matrix became spherical and were finally dissipated in order to minimize the interface energy between two phases. In the other layers except both lamella layers, polycrystal grains of AuSn₂ and AuSn₄ grew by normal grain growth during in situ heating. The high interface energy of nanoeutectic lamella and polygonal nanograins, which are formed by rapid solidification, acted as a principal driving force on the microstructural change during the in situ heating.

  7. High Dust Depletion in two Intervening Quasar Absorption Line Systems with the 2175 Å Extinction Bump at z ~ 1.4

    NASA Astrophysics Data System (ADS)

    Jiang, Peng; Ge, Jian; Prochaska, J. Xavier; Wang, Junfeng; Zhou, Hongyan; Wang, Tinggui

    2010-12-01

    We present the column densities of heavy elements and dust depletion studies in two strong Mg II absorption systems at z ~ 1.4 displaying the 2175 Å dust extinction feature. Column densities are measured from low-ionization absorption lines using an Apparent Optical Depth Method on the Keck/ESI spectra. We find that the dust depletion patterns resemble that of cold diffuse clouds in the Milky Way (MW). The values, [Fe/Zn] ≈-1.5 and [Si/Zn]<-0.67, are among the highest dust depletion measured for quasar absorption line systems. In another 2175 Å absorber at z = 1.64 toward the quasar SDSS J160457.50+220300.5, Noterdaeme et al. reported a similar dust depletion measurement ([Fe/Zn] = -1.47 and [Si/Zn] = -1.07) and detected C I and CO absorption lines on its VLT/UVES spectrum. We conclude that heavy dust depletion (i.e., a characteristic of cold dense clouds in MW) is required to produce a pronounced 2175 Å extinction bump. The data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

  8. Weak soft X-ray excesses need not result from the high-frequency tail of the optical/ultraviolet bump in active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Czerny, Bozena; Zycki, Piotr T.

    1994-01-01

    The broad-band ROSAT/EXOSAT X-ray spectra of six Seyfert 1 galaxies are fitted by a model consisting of a direct power law and a component due to reflection/reprocessing from a partially ionized, optically thick medium. The reflected spectrum contains emission features from various elements in the soft X-ray range. In all objects but one (Mrk 335), the fit is satisfactory, and no additional soft X-ray excess is required by the data. This means that in most sources there is no need for the thermal 'big blue bumps' to extend into soft X-rays, and the soft X-ray excesses reported previously can be explained by reflection/reprocessing. Satisfactory fits are obtained for a medium ionized by a source radiating at less than or approximately 15% of the Eddington rate. The fits require that the reflection is enhanced relative to an isotropically emitting source above a flat disk. The necessary high effectiveness of reflection in the soft X-ray band requires strong soft thermal flux dominating over hard X-rays.

  9. Axion Bounds from Precision Cosmology

    SciTech Connect

    Raffelt, G. G.; Hamann, J.; Hannestad, S.; Mirizzi, A.; Wong, Y. Y. Y.

    2010-08-30

    Depending on their mass, axions produced in the early universe can leave different imprints in cosmic structures. If axions have masses in the eV-range, they contribute a hot dark matter fraction, allowing one to constrain m{sub a} in analogy to neutrinos. In the more favored scenario where axions play the role of cold dark matter and if reheating after inflation does not restore the Peccei-Quinn symmetry, the axion field provides isocurvature fluctuations that are severely constrained by precision cosmology. There remains a small sliver in parameter space where isocurvature fluctuations could still show up in future probes.

  10. Precision alignment and mounting apparatus

    NASA Technical Reports Server (NTRS)

    Preston, Dennis R. (Inventor)

    1993-01-01

    An alignment and mounting apparatus for mounting two modules (10,12) includes a first portion having a cylindrical alignment pin (16) projecting normal to a module surface, a second portion having a three-stage alignment guide (18) including a shoehorn flange (34), a Y-slot (42) and a V-block (22) which sequentially guide the alignment pin (16) with successively finer precision and a third portion in the form of a spring-loaded captive fastener (20) for connecting the two modules after alignment is achieved.

  11. Precision Measurement Of Corneal Topography

    NASA Astrophysics Data System (ADS)

    Yoder, Paul R.; Macri, Timothy F.; Telfair, William B.; Bennett, Peter S.; Martin, Clifford A.; Warner, John W.

    1989-05-01

    We describe a new electro-optical device being developed to provide precise measurements of the three-dimensional topography of the human cornea. This device, called a digital keratoscope, is intended primarily for use in preparing for and determining the effect of corneal surgery procedures such as laser refractive keratectomy, radial keratotomy or corneal transplant on the refractive power of the cornea. It also may serve as an aid in prescribing contact lenses. The basic design features of the hardware and of the associated computer software are discussed, the means for alignment and calibration are described and typical results are given.

  12. Precision ozone vapor pressure measurements

    NASA Technical Reports Server (NTRS)

    Hanson, D.; Mauersberger, K.

    1985-01-01

    The vapor pressure above liquid ozone has been measured with a high accuracy over a temperature range of 85 to 95 K. At the boiling point of liquid argon (87.3 K) an ozone vapor pressure of 0.0403 Torr was obtained with an accuracy of + or - 0.7 percent. A least square fit of the data provided the Clausius-Clapeyron equation for liquid ozone; a latent heat of 82.7 cal/g was calculated. High-precision vapor pressure data are expected to aid research in atmospheric ozone measurements and in many laboratory ozone studies such as measurements of cross sections and reaction rates.

  13. Antihydrogen production and precision experiments

    SciTech Connect

    Nieto, M.M.; Goldman, T.; Holzscheiter, M.H.

    1996-12-31

    The study of CPT invariance with the highest achievable precision in all particle sectors is of fundamental importance for physics. Equally important is the question of the gravitational acceleration of antimatter. In recent years, impressive progress has been achieved in capturing antiprotons in specially designed Penning traps, in cooling them to energies of a few milli-electron volts, and in storing them for hours in a small volume of space. Positrons have been accumulated in large numbers in similar traps, and low energy positron or positronium beams have been generated. Finally, steady progress has been made in trapping and cooling neutral atoms. Thus the ingredients to form antihydrogen at rest are at hand. Once antihydrogen atoms have been captured at low energy, spectroscopic methods can be applied to interrogate their atomic structure with extremely high precision and compare it to its normal matter counterpart, the hydrogen atom. Especially the 1S-2S transition, with a lifetime of the excited state of 122 msec and thereby a natural linewidth of 5 parts in 10{sup 16}, offers in principle the possibility to directly compare matter and antimatter properties at a level of 1 part in 10{sup 16}.

  14. Automatic precision measurement of spectrograms.

    PubMed

    Palmer, B A; Sansonetti, C J; Andrew, K L

    1978-08-01

    A fully automatic comparator has been designed and implemented to determine precision wavelengths from high-resolution spectrograms. The accuracy attained is superior to that of an experienced operator using a semiautomatic comparator with a photoelectric setting device. The system consists of a comparator, slightly modified for simultaneous data acquisition from two parallel scans of the spectrogram, interfaced to a minicomputer. The software which controls the system embodies three innovations of special interest. (1) Data acquired from two parallel scans are compared and used to separate unknown from standard lines, to eliminate spurious lines, to identify blends of unknown with standard lines, to improve the accuracy of the measured positions, and to flag lines which require special examination. (2) Two classes of lines are automatically recognized and appropriate line finding methods are applied to each. This provides precision measurement for both simple and complex line profiles. (3) Wavelength determination using a least-squares fitted grating equation is supported in addition to polynomial interpolation. This is most useful in spectral regions with sparsely distributed standards. The principles and implementation of these techniques are fully described.

  15. Precision Measurements in 37K

    NASA Astrophysics Data System (ADS)

    Anholm, Melissa; Ashery, Daniel; Behling, Spencer; Fenker, Benjamin; Melconian, Dan; Mehlman, Michael; Behr, John; Gorelov, Alexandre; Olchanski, Konstantin; Preston, Claire; Warner, Claire; Gwinner, Gerald

    2015-10-01

    We have performed precision measurements of the kinematics of the daughter particles in the decay of 37K. This isotope decays by β+ emission in a mixed Fermi/Gamow-Teller transition to its isobaric analog, 37Ar. Because the higher-order standard model corrections to this decay process are well understood, it is an ideal candidate for for improving constraints on interactions beyond the standard model. Our setup utilizes a magneto-optical trap to confine and cool samples of 37K, which are then spin-polarized by optical pumping. This allows us to perform measurements on both polarized and unpolarized nuclei, which is valuable for a complete understanding of systematic effects. Precision measurements of this decay are expected to be sensitive to the presence of right-handed vector currents, as well as a linear combination of scalar and tensor currents. Progress towards a final result is presented here. Support provided by: NSERC, NRC through TRIUMF, DOE ER40773, Early Career ER41747, Israel Science Foundation.

  16. Precision metrology using weak measurements.

    PubMed

    Zhang, Lijian; Datta, Animesh; Walmsley, Ian A

    2015-05-29

    Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.

  17. Helium 3 neutron precision polarimetry

    NASA Astrophysics Data System (ADS)

    Menard, Christopher

    2009-10-01

    Measuring neutron polarization to a high degree of precision is critical for the next generation of neutron decay correlation experiments. Polarized neutrons are also used in experiments to probe the hadronic weak interaction which contributes a small portion (˜10-7) of the force between nucleons. Using a beam of cold neutrons at Los Alamos Neutron Science Center (LANSCE), we polarized neutrons and measured their absolute polarization to ˜0.1%. Neutrons were polarized by passing them through a ^3He spin filter, relying on the maximally spin dependent 3He neutron absorption cross section. The neutron polarization can be determined by measuring the wavelength-dependent neutron transmission through the ^3He cell. An independent measurement of the neutron polarization was also obtained by passing the polarized beam through an RF spin flipper and a second polarized ^3He cell, used as an analyzer. To measure the efficiency of the spin flipper, the same measurements were made after reversing the ^3He polarization in the polarizer by using NMR techniques (adiabatic fast passage). We will show the consistency of these two measurements and the resulting precision of neutron polarimetry using these techniques.

  18. Precision Environmental Radiation Monitoring System

    SciTech Connect

    Vladimir Popov, Pavel Degtiarenko

    2010-07-01

    A new precision low-level environmental radiation monitoring system has been developed and tested at Jefferson Lab. This system provides environmental radiation measurements with accuracy and stability of the order of 1 nGy/h in an hour, roughly corresponding to approximately 1% of the natural cosmic background at the sea level. Advanced electronic front-end has been designed and produced for use with the industry-standard High Pressure Ionization Chamber detector hardware. A new highly sensitive readout electronic circuit was designed to measure charge from the virtually suspended ionization chamber ion collecting electrode. New signal processing technique and dedicated data acquisition were tested together with the new readout. The designed system enabled data collection in a remote Linux-operated computer workstation, which was connected to the detectors using a standard telephone cable line. The data acquisition system algorithm is built around the continuously running 24-bit resolution 192 kHz data sampling analog to digital convertor. The major features of the design include: extremely low leakage current in the input circuit, true charge integrating mode operation, and relatively fast response to the intermediate radiation change. These features allow operating of the device as an environmental radiation monitor, at the perimeters of the radiation-generating installations in densely populated areas, like in other monitoring and security applications requiring high precision and long-term stability. Initial system evaluation results are presented.

  19. Precision Mass Measurements at CARIBU

    NASA Astrophysics Data System (ADS)

    Lascar, D.; van Schelt, J.; Savard, G.; Caldwell, S.; Chaudhuri, A.; Clark, J. A.; Levand, A. F.; Li, G.; Sternberg, M.; Sun, T.; Zabransky, B. J.; Segel, R.; Sharma, K.

    2010-02-01

    Neutron separation energies (Sn) are essential inputs to models of explosive r-process nucleosynthesis. However, for nuclei farther from stability, the precision of Sn decreases as production decreases and observation of those nuclei become more difficult. Many of the most critical inputs to the models are based on extrapolations from measurements of masses closer to stability than the predicted r-process path. Measuring masses that approach and lie on the predicted r-process path will further constrain the systematic uncertainties in these extrapolated values. The Canadian Penning Trap Mass Spectrometer (CPT) at Argonne National Laboratory (ANL) has measured the masses of more than 160 nuclei to high precision. A recent move to the CAlifornium Rare Isotope Breeder Upgrade (CARIBU) at ANL has given the CPT unique access to weakly produced nuclei that cannot be easily reached via proton induced fission of ^238U. CARIBU will eventually use a 1 Ci source of ^252Cf to produce these nuclei. Installation of the CPT at CARIBU as well as the first CPT mass measurements of neutron rich nuclei at CARIBU will be discussed. )

  20. High-precision photometry for K2 Campaign 1

    NASA Astrophysics Data System (ADS)

    Huang, C. X.; Penev, K.; Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Domsa, I.; de Val-Borro, M.

    2015-12-01

    The two reaction wheel K2 mission promises and has delivered new discoveries in the stellar and exoplanet fields. However, due to the loss of accurate pointing, it also brings new challenges for the data reduction processes. In this paper, we describe a new reduction pipeline for extracting high-precision photometry from the K2 data set, and present public light curves for the K2 Campaign 1 target pixel data set. Key to our reduction is the derivation of global astrometric solutions from the target stamps, from which accurate centroids are passed on for high-precision photometry extraction. We extract target light curves for sources from a combined UCAC4 and EPIC catalogue - this includes not only primary targets of the K2 campaign 1, but also any other stars that happen to fall on the pixel stamps. We provide the raw light curves, and the products of various detrending processes aimed at removing different types of systematics. Our astrometric solutions achieve a median residual of ˜0.127 arcsec. For bright stars, our best 6.5 h precision for raw light curves is ˜20 parts per million (ppm). For our detrended light curves, the best 6.5 h precision achieved is ˜15 ppm. We show that our detrended light curves have fewer systematic effects (or trends, or red-noise) than light curves produced by other groups from the same observations. Example light curves of transiting planets and a Cepheid variable candidate, are also presented. We make all light curves public, including the raw and detrended photometry, at http://k2.hatsurveys.org.

  1. The AGS new fast extraction system for the g-2 experiment and RHIC injection

    SciTech Connect

    Tanaka, M.; Lee, Y.Y.

    1991-01-01

    The AGS requires a new fast extraction beam (NewFEB) system for the muon g-2 experiment and the Relativistic Heavy Ion Collider (RHIC). The proposed NewFEB system will consist of a new fast multi-pulsing kicker placed at straight section G10 and an ejector septum magnet at H10, together will local orbit bumps generated by powering backleg windings on the AGS main magnets. The new system is capable of performing single bunch multiple extraction as often as every 8 ms up to 12 times per AGS cycle, in addition to the standard single turn fast extraction. The conceptual design of the NewFEB system will be discussed. 3 refs., 3 figs., 1 tab.

  2. The Quantitative Imaging Network in Precision Medicine

    PubMed Central

    Nordstrom, Robert J.

    2017-01-01

    Precision medicine is a healthcare model that seeks to incorporate a wealth of patient information to identify and classify disease progression and to provide tailored therapeutic solutions for individual patients. Interventions are based on knowledge of molecular and mechanistic causes, pathogenesis and pathology of disease. Individual characteristics of the patients are then used to select appropriate healthcare options. Imaging is playing an increasingly important role in identifying relevant characteristics that help to stratify patients for different interventions. However, lack of standards, limitations in image-processing interoperability, and errors in data collection can limit the applicability of imaging in clinical decision support. Quantitative imaging is the attempt to extract reliable, numerical information from images to eliminate qualitative judgments and errors for providing accurate measures of tumor response to therapy or for predicting future response. This issue of Tomography reports quantitative imaging developments made by several members of the National Cancer Institute Quantitative Imaging Network, a program dedicated to the promotion of quantitative imaging methods for clinical decision support. PMID:28083563

  3. The Precision Field Lysimeter Concept

    NASA Astrophysics Data System (ADS)

    Fank, J.

    2009-04-01

    The understanding and interpretation of leaching processes have improved significantly during the past decades. Unlike laboratory experiments, which are mostly performed under very controlled conditions (e.g. homogeneous, uniform packing of pre-treated test material, saturated steady-state flow conditions, and controlled uniform hydraulic conditions), lysimeter experiments generally simulate actual field conditions. Lysimeters may be classified according to different criteria such as type of soil block used (monolithic or reconstructed), drainage (drainage by gravity or vacuum or a water table may be maintained), or weighing or non-weighing lysimeters. In 2004 experimental investigations have been set up to assess the impact of different farming systems on groundwater quality of the shallow floodplain aquifer of the river Mur in Wagna (Styria, Austria). The sediment is characterized by a thin layer (30 - 100 cm) of sandy Dystric Cambisol and underlying gravel and sand. Three precisely weighing equilibrium tension block lysimeters have been installed in agricultural test fields to compare water flow and solute transport under (i) organic farming, (ii) conventional low input farming and (iii) extensification by mulching grass. Specific monitoring equipment is used to reduce the well known shortcomings of lysimeter investigations: The lysimeter core is excavated as an undisturbed monolithic block (circular, 1 m2 surface area, 2 m depth) to prevent destruction of the natural soil structure, and pore system. Tracing experiments have been achieved to investigate the occurrence of artificial preferential flow and transport along the walls of the lysimeters. The results show that such effects can be neglected. Precisely weighing load cells are used to constantly determine the weight loss of the lysimeter due to evaporation and transpiration and to measure different forms of precipitation. The accuracy of the weighing apparatus is 0.05 kg, or 0.05 mm water equivalent

  4. Precision grip and Parkinson's disease.

    PubMed

    Fellows, S J; Noth, J; Schwarz, M

    1998-09-01

    In order to investigate sensorimotor processing and force development in Parkinson's disease, 16 patients, four patients with hemiparkinsonism and 12 age-matched normal subjects were assessed during lifting and holding of an object in a precision grip between thumb and forefinger, or holding the object in this grip at a fixed height above a table. In the former case, object loading could be changed between lifts without warning. In the latter case, unexpected step load changes to the object were applied to the object with a torque motor. All procedures could be applied with or without visual control of the hand and the object. Normal subjects lifted an unpredictable load employing the grip force parameters used in the preceding lift. If a load change was encountered, the parameters became adapted to the new conditions during the lift, modulating grip forces to match the loading. Parkinsonian patients retained this strategy and the ability to regulate grip forces according to load. Under all conditions, however, parkinsonian subjects developed abnormally high grip forces in both the lift and the hold phase, although the ratio of these forces remained normal. Lifting height was normal in parkinsonian subjects, but the duration of the lifting task was significantly prolonged, due to a marked slowing in the rate of grip force development in the lead-up to object lift-off and to prolongation of the movement phase. Forewarning of object loading, with or without visual control, did not reduce timing deficits or improve the rate of grip force development. However, it did allow parkinsonian subjects to reduce the safety margin significantly. Responses to step load changes imposed during holding without visual control showed minor abnormalities in the parkinsonian patients: onset latencies and EMG activity in the first dorsal interosseus and thenar muscles were normal up to 140 ms after displacement. Subsequent EMG activity in the first dorsal interosseus remained largely

  5. Using hyperspectral data in precision farming applications

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision farming practices such as variable rate applications of fertilizer and agricultural chemicals require accurate field variability mapping. This chapter investigated the value of hyperspectral remote sensing in providing useful information for five applications of precision farming: (a) Soil...

  6. Role of telecommunications in precision agriculture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision agriculture has been made possible by the confluence of several technologies: geographic positioning systems, geographic information systems, image analysis software, low-cost microcomputer-based variable rate controller/recorders, and precision tractor guidance systems. While these techn...

  7. Precision cosmology and the landscape

    SciTech Connect

    Bousso, Raphael; Bousso, Raphael

    2006-10-01

    After reviewing the cosmological constant problem -- why is Lambda not huge? -- I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments.

  8. RaDARSAT precision transponder

    NASA Astrophysics Data System (ADS)

    Hawkins, R. K.; Teany, L. D.; Srivastava, S.; Tam, S. Y. K.

    1997-05-01

    This paper describes the set of four RADARSAT Precision Transponders (RPTs) developed for the Canadian Space Agency for the calibration and qualification of the spaceborne Synthetic Aperture Radar (SAR) carried on the Canadian remote sensing satellite known as RADARSAT, launched in November, 1995. The transponder system block diagram, RF diagram, and specification development are described, as well as the overall program which gives the transponder function in the calibration program for RADARSAT. The transponders are deployed at four strategically situated sites across Canada: Fredericton, NB; Ottawa, Ont.; Prince Albert, Sask.; and Resolute, NWT. Some details of the sites and their sensor visitation characteristics are given. Also provided are some early results showing the use and performance of the transponders using ERS-1/2 and RADARSAT.

  9. System for precise position registration

    DOEpatents

    Sundelin, Ronald M.; Wang, Tong

    2005-11-22

    An apparatus for enabling accurate retaining of a precise position, such as for reacquisition of a microscopic spot or feature having a size of 0.1 mm or less, on broad-area surfaces after non-in situ processing. The apparatus includes a sample and sample holder. The sample holder includes a base and three support posts. Two of the support posts interact with a cylindrical hole and a U-groove in the sample to establish location of one point on the sample and a line through the sample. Simultaneous contact of the third support post with the surface of the sample defines a plane through the sample. All points of the sample are therefore uniquely defined by the sample and sample holder. The position registration system of the current invention provides accuracy, as measured in x, y repeatability, of at least 140 .mu.m.

  10. Precision moisture generation and measurement.

    SciTech Connect

    Thornberg, Steven Michael; White, Michael I.; Irwin, Adriane Nadine

    2010-03-01

    In many industrial processes, gaseous moisture is undesirable as it can lead to metal corrosion, polymer degradation, and other materials aging processes. However, generating and measuring precise moisture concentrations is challenging due to the need to cover a broad concentration range (parts-per-billion to percent) and the affinity of moisture to a wide range surfaces and materials. This document will discuss the techniques employed by the Mass Spectrometry Laboratory of the Materials Reliability Department at Sandia National Laboratories to generate and measure known gaseous moisture concentrations. This document highlights the use of a chilled mirror and primary standard humidity generator for the characterization of aluminum oxide moisture sensors. The data presented shows an excellent correlation in frost point measured between the two instruments, and thus provides an accurate and reliable platform for characterizing moisture sensors and performing other moisture related experiments.

  11. Ultrasonic precision optical grinding technology

    NASA Astrophysics Data System (ADS)

    Cahill, Michael J.; Bechtold, Michael J.; Fess, Edward; Wolfs, Frank L.; Bechtold, Rob

    2015-10-01

    As optical geometries become more precise and complex and a wider range of materials are used, the processes used for manufacturing become more critical. As the preparatory stage for polishing, this is especially true for grinding. Slow processing speeds, accelerated tool wear, and poor surface quality are often detriments in manufacturing glass and hard ceramics. The quality of the ground surface greatly influences the polishing process and the resulting finished product. Through extensive research and development, OptiPro Systems has introduced an ultrasonic assisted grinding technology, OptiSonic, which has numerous advantages over traditional grinding processes. OptiSonic utilizes a custom tool holder designed to produce oscillations in line with the rotating spindle. A newly developed software package called IntelliSonic is integral to this platform. IntelliSonic automatically characterizes the tool and continuously optimizes the output frequency for optimal cutting while in contact with the part. This helps maintain a highly consistent process under changing load conditions for a more accurate surface. Utilizing a wide variety of instruments, test have proven to show a reduction in tool wear and increase in surface quality while allowing processing speeds to be increased. OptiSonic has proven to be an enabling technology to overcome the difficulties seen in grinding of glass and hard optical ceramics. OptiSonic has demonstrated numerous advantages over the standard CNC grinding process. Advantages are evident in reduced tool wear, better surface quality, and reduced cycle times due to increased feed rates. These benefits can be seen over numerous applications within the precision optics industry.

  12. Precision grinding process development for brittle materials

    SciTech Connect

    Blaedel, K L; Davis, P J; Piscotty, M A

    1999-04-01

    High performance, brittle materials are the materials of choice for many of today's engineering applications. This paper describes three separate precision grinding processes developed at Lawrence Liver-more National Laboratory to machine precision ceramic components. Included in the discussion of the precision processes is a variety of grinding wheel dressing, truing and profiling techniques.

  13. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Precision attachment. 872.3165 Section 872.3165...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75...

  14. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Precision attachment. 872.3165 Section 872.3165...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75...

  15. Precision Farming and Conservation Advances Agricultural Sustainability

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To many, Precision Farming, more formally termed Precision Agriculture, seems like an oxymoron. Yet site-specific management makes sense to an exponentially growing number of farmers. So where is Precision Farming headed? The short answer is that it is being extended from a focus on crop productio...

  16. Precision of multi-frequency electronic apex locators.

    PubMed

    George, Roy

    2016-09-01

    Data sourcesCochrane Central Register of Controlled Trials, Medline, Embase and Scopus databases.Study selectionStudies that reported the precision of electronic apex locators (EALs) in locating the apical constriction (AC) in primary root canal treatment of human teeth compared with a histologic evaluation of the AC were considered.Data extraction and synthesisData were extracted and quality assessed independently by two reviewers.ResultsTen studies were included, reporting on 1105 EAL measurements. Seven studies were considered to be at high risk of bias and three at low risk. Four different EALs were evaluated; Root ZX (J Morita, Tokyo, Japan), Justy II (Hager & Werken GmbH & Co, Duisburg, Germany), Endy 5000 (Loser Co, Leverkusen, Germany) and Endox (Lysis Co, Milan, Italy). Three EALs, Root ZX, Justy II and Endy 5000 were more accurate than the Endox in determining the distance between the file tip and the apical constriction. Pulp status was only available for 194 (17.55%) of the measurements. The status of the pulp (vital or necrotic) had no significant effect on precision.ConclusionsThe precision of electronic working length measurement depends on the device used and the type of irrigation and is not influenced by the status of the pulp tissue.

  17. In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

    PubMed Central

    Winzer, Pablo; Müller, Joachim; Aguado-Martínez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K.; Fan, Erkang; Maly, Dustin J.; Van Voorhis, Wesley C.

    2015-01-01

    We report on the in vitro effects of the bumped kinase inhibitor 1294 (BKI-1294) in cultures of virulent Neospora caninum isolates Nc-Liverpool (Nc-Liv) and Nc-Spain7 and in two strains of Toxoplasma gondii (RH and ME49), all grown in human foreskin fibroblasts. In these parasites, BKI-1294 acted with 50% inhibitory concentrations (IC50s) ranging from 20 nM (T. gondii RH) to 360 nM (N. caninum Nc-Liv), and exposure of intracellular stages to 1294 led to the nondisjunction of newly formed tachyzoites, resulting in the formation of multinucleated complexes similar to complexes previously observed in BKI-1294-treated N. caninum beta-galactosidase-expressing parasites. However, such complexes were not seen in a transgenic T. gondii strain that expressed CDPK1 harboring a mutation (G to M) in the gatekeeper residue. In T. gondii ME49 and N. caninum Nc-Liv, exposure of cultures to BKI-1294 resulted in the elevated expression of mRNA coding for the bradyzoite marker BAG1. Unlike in bradyzoites, SAG1 expression was not repressed. Immunofluorescence also showed that these multinucleated complexes expressed SAG1 and BAG1 and the monoclonal antibody CC2, which binds to a yet unidentified bradyzoite antigen, also exhibited increased labeling. In a pregnant mouse model, BKI-1294 efficiently inhibited vertical transmission in BALB/c mice experimentally infected with one of the two virulent isolates Nc-Liv or Nc-Spain7, demonstrating proof of concept that this compound protected offspring from vertical transmission and disease. The observed deregulated antigen expression effect may enhance the immune response during BKI-1294 therapy and will be the subject of future studies. PMID:26248379

  18. Precision Adjustable Liquid Regulator (ALR)

    NASA Astrophysics Data System (ADS)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  19. EXPRES: the EXtreme PREcision Spectrograph at the Discovery Channel Telescope

    NASA Astrophysics Data System (ADS)

    Fischer, Debra; Jurgenson, Colby; McCracken, Tyler; Sawyer, David; Blackman, Ryan; Szymkowiak, Andrew E.

    2017-01-01

    In 2017, we will commission EXPRES at the DCT to carry out a high precision radial velocity planet search. The instrument has a resolution of R=150,000 and spans a wavelength range from 390 - 680 nm. There are several features designed to ensure high fidelity spectra: a well scrambled fiber coupling, vibration isolation, a vacuum enclosure to maintain temperature stability to better than 1 mK and pressure stability better than 1 mTorr. The spectrometer has a unique flat-fielding system and a wavelength-dependent exposure meter. The laser frequency comb provides wavelength precision better than 5 cm/s and the overall instrumental error budget is 17 cm/s for a single observation. The fully characterized CCD detector has 9-micron pixels and a 10K by 10K format. The instrument will be commissioned for facility use with a fully automated extraction and Doppler analysis pipeline.This instrument and our analytial techniques aim to push the experiemental frontier on extreme Doppler precision toward 10 cm/s. Progress on RV precision is critical for measuring masses of exoplanets so that we can derive densities for small transiting planets and interpret the spectra of exoplanet atmospheres. We will carry out a survey of 50 bright stars in the first year after commissioning EXPRES.

  20. The Age of Precision Cosmology

    NASA Technical Reports Server (NTRS)

    Chuss, David T.

    2012-01-01

    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  1. High precision redundant robotic manipulator

    DOEpatents

    Young, Kar-Keung David

    1998-01-01

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degreed of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns.

  2. Precise quantification of nanoparticle internalization.

    PubMed

    Gottstein, Claudia; Wu, Guohui; Wong, Benjamin J; Zasadzinski, Joseph Anthony

    2013-06-25

    Nanoparticles have opened new exciting avenues for both diagnostic and therapeutic applications in human disease, and targeted nanoparticles are increasingly used as specific drug delivery vehicles. The precise quantification of nanoparticle internalization is of importance to measure the impact of physical and chemical properties on the uptake of nanoparticles into target cells or into cells responsible for rapid clearance. Internalization of nanoparticles has been measured by various techniques, but comparability of data between different laboratories is impeded by lack of a generally accepted standardized assay. Furthermore, the distinction between associated and internalized particles has been a challenge for many years, although this distinction is critical for most research questions. Previously used methods to verify intracellular location are typically not quantitative and do not lend themselves to high-throughput analysis. Here, we developed a mathematical model which integrates the data from high-throughput flow cytometry measurements with data from quantitative confocal microscopy. The generic method described here will be a useful tool in biomedical nanotechnology studies. The method was then applied to measure the impact of surface coatings of vesosomes on their internalization by cells of the reticuloendothelial system (RES). RES cells are responsible for rapid clearance of nanoparticles, and the resulting fast blood clearance is one of the major challenges in biomedical applications of nanoparticles. Coating of vesosomes with long chain polyethylene glycol showed a trend for lower internalization by RES cells.

  3. High precision redundant robotic manipulator

    DOEpatents

    Young, K.K.D.

    1998-09-22

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space is disclosed. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degrees of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns. 3 figs.

  4. PRECISION TIME-DELAY GENERATOR

    DOEpatents

    Carr, B.J.; Peckham, V.D.

    1959-06-16

    A precision time-delay generator circuit with low jitter is described. The first thyratron has a series resonant circuit and a diode which is connected to the second thyratron. The first thyratron is triggered at the begin-ning of a time delay and a capacitor is discharged through the first thyratron and the diode, thereby, triggering the second thyratron. (T.R.H.) l6l9O The instrument described can measure pressures between sea level and 300,000 ft. The pressure- sensing transducer of the instrument is a small cylindrical tube with a thin foil of titanium-tritium fastened around the inside of the tube. Output is a digital signal which can be used for storage or telemetering more conveniently than an analog signal. (W.D.M.) l6l9l An experimental study was made on rolling contacts in the temperature range of 550 to 1000 deg F. Variables such as material composition, hardness, and operating conditions were investigated in a rolling test stand. Ball bearing tests were run to determine the effect of design parameters, bearing materials, lubricants, and operating conditions. (auth)

  5. Control of precision pointing system

    NASA Astrophysics Data System (ADS)

    Gu, Zheng

    Distributed-parameter modeling of tube with moving mass using Magnetic Compressional Damping Treatment (MCDT) is developed. Hamilton's principle is utilized to develop the model and boundary condition of a tube with moving mass using MCDT. Based on the electromagnetic theory, the relation between the generated magnet force of the actuator (MCDT) and the control current is determined. A stable control strategy is developed to damp out the vibration of the tube with moving mass using MCDT system. The fundamental characteristics of an active and a passive version of the Magnetic Compressional Damping Treatment (MCDT) are investigated by the finite element method. The damping characteristics of tube/MCDT system are modeled by Golla-Hughes-McTavish (GHM) method in order to predict the tube response in the time domain. The numerical results are verified through experimentation using a cantilevered tube treated with MCDT at the free end. The tube vibration due to an internally moving load is controlled by the MCDT using a deflection feedback controller. Close agreement is obtained between theory and experiments. The effectiveness of the MCDT in attenuating structural vibration of the tube has also been clearly demonstrated in the time and frequency domains. The developed theoretical and experimental techniques present invaluable tools for designing and predicting the performance of precision pointing tubes different damping treatments when subjected to moving loads.

  6. Precision of circular systematic sampling.

    PubMed

    Cruz-Orive, L M; Gual-Arnau, X

    2002-09-01

    In design stereology, many estimators require isotropic orientation of a test probe relative to the object in order to attain unbiasedness. In such cases, systematic sampling of orientations becomes imperative on grounds of efficiency and practical applicability. For instance, the planar nucleator and the vertical rotator imply systematic sampling on the circle, whereas the Buffon-Steinhaus method to estimate curve length in the plane, or the vertical designs to estimate surface area and curve length, imply systematic sampling on the semicircle. This leads to the need for predicting the precision of systematic sampling on the circle and the semicircle from a single sample. There are two main prediction approaches, namely the classical one of G. Matheron for non-necessarily periodic measurement functions, and a recent approach based on a global symmetric model of the covariogram, more specific for periodic measurement functions. The latter approach seems at least as satisfactory as the former for small sample sizes, and it is developed here incorporating local errors. Detailed examples illustrating common stereological tools are included.

  7. Ultra-precision positioning assembly

    DOEpatents

    Montesanti, Richard C.; Locke, Stanley F.; Thompson, Samuel L.

    2002-01-01

    An apparatus and method is disclosed for ultra-precision positioning. A slide base provides a foundational support. A slide plate moves with respect to the slide base along a first geometric axis. Either a ball-screw or a piezoelectric actuator working separate or in conjunction displaces the slide plate with respect to the slide base along the first geometric axis. A linking device directs a primary force vector into a center-line of the ball-screw. The linking device consists of a first link which directs a first portion of the primary force vector to an apex point, located along the center-line of the ball-screw, and a second link for directing a second portion of the primary force vector to the apex point. A set of rails, oriented substantially parallel to the center-line of the ball-screw, direct movement of the slide plate with respect to the slide base along the first geometric axis and are positioned such that the apex point falls within a geometric plane formed by the rails. The slide base, the slide plate, the ball-screw, and the linking device together form a slide assembly. Multiple slide assemblies can be distributed about a platform. In such a configuration, the platform may be raised and lowered, or tipped and tilted by jointly or independently displacing the slide plates.

  8. Scoring of precision spur gears

    SciTech Connect

    Budinski, K.G. )

    1994-09-01

    A group of manufacturing machines employed precision spur gears as the timing mechanism for machine operations. These machines had worked successfully for about ten years with little or no problems with gear wear or deterioration. When new machines were brought on line with recently made gears there were immediate problems with gear tooth scoring. A laboratory study was conducted to determine if metallurgical conditions were related to the gear scoring. Recent gears were made from a modification of the alloy used in early gears. The new alloy has been modified to make it more resistant to softening in coating operations. Reciprocating wear tests and galling tests were conducted to compare the tribological characteristics of the old and new gear steels. It was determined that the threshold galling stress of the gear steels was strongly dependent on the hardness. The reciprocating wear tests indicated that the wear resistance was affected by the volume fraction of hard phases in the steels. The recommended short-term solution was to alter the tempering procedure for the steel to keep Rockwell C hardness above 60; the long-term solution was to change the gear material and lubrication.

  9. High Precision Measurement of the ^19Ne Lifetime

    NASA Astrophysics Data System (ADS)

    Broussard, Leah; Back, H. O.; Boswell, M. S.; Crowell, A. S.; Howell, C. R.; Kidd, M. F.; Pattie, R. W., Jr.; Young, A. R.; Dendooven, P. G.; Giri, G. S.; van der Hoek, D. J.; Jungmann, K.; Kruithof, W. L.; Onderwater, C. J. G.; Santra, B.; Shidling, P. D.; Sohani, M.; Versolota, O. O.; Willmann, L.; Wilschut, H. W.

    2009-10-01

    Recently, a rigorous review of the T=12 mirror transitions has identified several systems which can contribute to high precision tests exploring deviations from the Standard Model's description of the electroweak interaction. Arguably, one of the best candidates is the &+circ; decay of ^19Ne to ^19F. In this system, the main contribution to the uncertainty of extracted Standard Model parameters is due to the measured value of the lifetime of the decay. In March 2009, a high precision measurement of the lifetime of ^19Ne was made by a collaboration between the Triangle Universities Nuclear Laboratory (TUNL) and the Kernfysisch Versneller Instituut (KVI) at the Trapped Radioactive Isotopes: Microlaboratories for Fundamental Physics (Triμp) facility. An overview of the experiment and preliminary results will be presented.

  10. Report of the Working Group on precision measurements

    SciTech Connect

    Raymond L. Brock et al.

    2001-10-03

    Precision measurements of electroweak quantities are carried out to test the Standard Model (SM). In particular, measurements of the top quark mass, m{sub top}, when combined with precise measurements of the W mass, M{sub W}, and the weak mixing angle, sin{sup 2} {bar {theta}}{sub W}, make it possible to derive indirect constraints on the Higgs boson mass, M{sub H}, via top quark and Higgs boson electroweak radiative corrections to M{sub W}. Comparison of these constraints on M{sub H} with the mass obtained from direct observation of the Higgs boson in future collider experiments will be an important test of the SM. In this report, the prospects for measuring the W parameters (mass and width) and the weak mixing angle in Run II are discussed, and a program for extracting the probability distribution function of M{sub H} is described.

  11. Future paradigms for precision oncology.

    PubMed

    Klement, Giannoula Lakka; Arkun, Knarik; Valik, Dalibor; Roffidal, Tina; Hashemi, Ali; Klement, Christos; Carmassi, Paolo; Rietman, Edward; Slaby, Ondrej; Mazanek, Pavel; Mudry, Peter; Kovacs, Gabor; Kiss, Csongor; Norga, Koen; Konstantinov, Dobrin; André, Nicolas; Slavc, Irene; van Den Berg, Henk; Kolenova, Alexandra; Kren, Leos; Tuma, Jiri; Skotakova, Jarmila; Sterba, Jaroslav

    2016-07-19

    Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments problematic. The conventional diagnostic categories, while necessary for care, thwart the use of molecular information for treatment as molecular characteristics cross tissue types.This is compounded by the struggle to keep abreast the scientific advances made in all fields of science, and by the enormous challenge to organize, cross-reference, and apply molecular data for patient benefit. In order to supplement the site-specific, histology-driven diagnosis with genomic, proteomic and metabolomics information, a paradigm shift in diagnosis and treatment of patients is required.While most physicians are open and keen to use the emerging data for therapy, even those versed in molecular therapeutics are overwhelmed with the amount of available data. It is not surprising that even though The Human Genome Project was completed thirteen years ago, our patients have not benefited from the information. Physicians cannot, and should not be asked to process the gigabytes of genomic and proteomic information on their own in order to provide patients with safe therapies. The following consensus summary identifies the needed for practice changes, proposes potential solutions to the present crisis of informational overload, suggests ways of providing physicians with the tools necessary for interpreting patient specific molecular profiles, and facilitates the implementation of quantitative precision medicine. It also provides two case studies where this approach has been used.

  12. Precision laser automatic tracking system.

    PubMed

    Lucy, R F; Peters, C J; McGann, E J; Lang, K T

    1966-04-01

    A precision laser tracker has been constructed and tested that is capable of tracking a low-acceleration target to an accuracy of about 25 microrad root mean square. In tracking high-acceleration targets, the error is directly proportional to the angular acceleration. For an angular acceleration of 0.6 rad/sec(2), the measured tracking error was about 0.1 mrad. The basic components in this tracker, similar in configuration to a heliostat, are a laser and an image dissector, which are mounted on a stationary frame, and a servocontrolled tracking mirror. The daytime sensitivity of this system is approximately 3 x 10(-10) W/m(2); the ultimate nighttime sensitivity is approximately 3 x 10(-14) W/m(2). Experimental tests were performed to evaluate both dynamic characteristics of this system and the system sensitivity. Dynamic performance of the system was obtained, using a small rocket covered with retroreflective material launched at an acceleration of about 13 g at a point 204 m from the tracker. The daytime sensitivity of the system was checked, using an efficient retroreflector mounted on a light aircraft. This aircraft was tracked out to a maximum range of 15 km, which checked the daytime sensitivity of the system measured by other means. The system also has been used to track passively stars and the Echo I satellite. Also, the system tracked passively a +7.5 magnitude star, and the signal-to-noise ratio in this experiment indicates that it should be possible to track a + 12.5 magnitude star.

  13. Future paradigms for precision oncology

    PubMed Central

    Klement, Giannoula Lakka; Arkun, Knarik; Valik, Dalibor; Roffidal, Tina; Hashemi, Ali; Klement, Christos; Carmassi, Paolo; Rietman, Edward; Slaby, Ondrej; Mazanek, Pavel; Mudry, Peter; Kovacs, Gabor; Kiss, Csongor; Norga, Koen; Konstantinov, Dobrin; André, Nicolas; Slavc, Irene; van Den Berg, Henk; Kolenova, Alexandra; Kren, Leos; Tuma, Jiri; Skotakova, Jarmila; Sterba, Jaroslav

    2016-01-01

    Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments problematic. The conventional diagnostic categories, while necessary for care, thwart the use of molecular information for treatment as molecular characteristics cross tissue types. This is compounded by the struggle to keep abreast the scientific advances made in all fields of science, and by the enormous challenge to organize, cross-reference, and apply molecular data for patient benefit. In order to supplement the site-specific, histology-driven diagnosis with genomic, proteomic and metabolomics information, a paradigm shift in diagnosis and treatment of patients is required. While most physicians are open and keen to use the emerging data for therapy, even those versed in molecular therapeutics are overwhelmed with the amount of available data. It is not surprising that even though The Human Genome Project was completed thirteen years ago, our patients have not benefited from the information. Physicians cannot, and should not be asked to process the gigabytes of genomic and proteomic information on their own in order to provide patients with safe therapies. The following consensus summary identifies the needed for practice changes, proposes potential solutions to the present crisis of informational overload, suggests ways of providing physicians with the tools necessary for interpreting patient specific molecular profiles, and facilitates the implementation of quantitative precision medicine. It also provides two case studies where this approach has been used. PMID:27223079

  14. Shuttle orbit IMU alignment. Single-precision computation error

    NASA Technical Reports Server (NTRS)

    Mcclain, C. R.

    1980-01-01

    The source of computational error in the inertial measurement unit (IMU) onorbit alignment software was investigated. Simulation runs were made on the IBM 360/70 computer with the IMU orbit alignment software coded in hal/s. The results indicate that for small IMU misalignment angles (less than 600 arc seconds), single precision computations in combination with the arc cosine method of eigen rotation angle extraction introduces an additional misalignment error of up to 230 arc seconds per axis. Use of the arc sine method, however, produced negligible misalignment error. As a result of this study, the arc sine method was recommended for use in the IMU onorbit alignment software.

  15. Precise digital demodulation for fiber optic interferometer sensors

    NASA Astrophysics Data System (ADS)

    Medvedev, Andrei; Berezhnoi, Andrei; Kudryashov, Aleksei; Liokumovich, Leonid

    2016-03-01

    Different methods are used in the interferometer sensors for target signal extraction. Digital technologies provide new opportunities for precise signal detection. We have developed the principle of signal demodulation using an additional harmonic phase modulation and digital signal processing. The principle allows implementation of processing algorithms using different ratios between modulation and discretization frequencies. The expressions allowing calculation of the phase difference using the inverse trigonometric functions were derived. The method was realized in LabVIEW programming environment and was demonstrated for various signal shapes.

  16. High precision measurement of the proton charge radius: The PRad experiment

    SciTech Connect

    Meziane, Mehdi

    2013-11-01

    The recent high precision measurements of the proton charge radius performed at PSI from muonic hydrogen Lamb shift puzzled the hadronic physics community. A value of 0.8418 {+-} 0.0007 fm was extracted which is 7{sigma} smaller than the previous determinations obtained from electron-proton scattering experiments and based on precision spectroscopy of electronic hydrogen. An additional extraction of the proton charge radius from electron scattering at Mainz is also in good agreement with these "electronic" determinations. An independent measurement of the proton charge radius from unpolarized elastic ep scattering using a magnetic spectrometer free method was proposed and fully approved at Jefferson Laboratory in June 2012. This novel technique uses the high precision calorimeter HyCal and a windowless hydrogen gas target which makes possible the extraction of the charge radius at very forward angles and thus very low momentum transfer Q{sup 2} up to 10{sup -4} (GeV/c){sup 2} with an unprecedented sub-percent precision for this type of experiment. In this paper, after a review of the recent progress on the proton charge radius extraction and the new high precision experiment PRad will be presented.

  17. High precision measurement of the proton charge radius: The PRad experiment

    SciTech Connect

    Meziane, Mehdi; Collaboration: PRad Collaboration

    2013-11-07

    The recent high precision measurements of the proton charge radius performed at PSI from muonic hydrogen Lamb shift puzzled the hadronic physics community. A value of 0.8418 ± 0.0007 fm was extracted which is 7σ smaller than the previous determinations obtained from electron-proton scattering experiments and based on precision spectroscopy of electronic hydrogen. An additional extraction of the proton charge radius from electron scattering at Mainz is also in good agreement with these 'electronic' determinations. An independent measurement of the proton charge radius from unpolarized elastic ep scattering using a magnetic spectrometer free method was proposed and fully approved at Jefferson Laboratory in June 2012. This novel technique uses the high precision calorimeter HyCal and a windowless hydrogen gas target which makes possible the extraction of the charge radius at very forward angles and thus very low momentum transfer Q{sup 2} up to 10{sup −4} (GeV/c){sup 2} with an unprecedented sub-percent precision for this type of experiment. In this paper, after a review of the recent progress on the proton charge radius extraction and the new high precision experiment PRad will be presented.

  18. Precision Medicine, Cardiovascular Disease and Hunting Elephants.

    PubMed

    Joyner, Michael J

    2016-01-01

    Precision medicine postulates improved prediction, prevention, diagnosis and treatment of disease based on patient specific factors especially DNA sequence (i.e., gene) variants. Ideas related to precision medicine stem from the much anticipated "genetic revolution in medicine" arising seamlessly from the human genome project (HGP). In this essay I deconstruct the concept of precision medicine and raise questions about the validity of the paradigm in general and its application to cardiovascular disease. Thus far precision medicine has underperformed based on the vision promulgated by enthusiasts. While niche successes for precision medicine are likely, the promises of broad based transformation should be viewed with skepticism. Open discussion and debate related to precision medicine are urgently needed to avoid misapplication of resources, hype, iatrogenic interventions, and distraction from established approaches with ongoing utility. Failure to engage in such debate will lead to negative unintended consequences from a revolution that might never come.

  19. High precision modeling for fundamental physics experiments

    NASA Astrophysics Data System (ADS)

    Rievers, Benny; Nesemann, Leo; Costea, Adrian; Andres, Michael; Stephan, Ernst P.; Laemmerzahl, Claus

    With growing experimental accuracies and high precision requirements for fundamental physics space missions the needs for accurate numerical modeling techniques are increasing. Motivated by the challenge of length stability in cavities and optical resonators we propose the develop-ment of a high precision modeling tool for the simulation of thermomechanical effects up to a numerical precision of 10-20 . Exemplary calculations for simplified test cases demonstrate the general feasibility of high precision calculations and point out the high complexity of the task. A tool for high precision analysis of complex geometries will have to use new data types, advanced FE solver routines and implement new methods for the evaluation of numerical precision.

  20. [Progress in precision medicine: a scientific perspective].

    PubMed

    Wang, B; Li, L M

    2017-01-10

    Precision medicine is a new strategy for disease prevention and treatment by taking into account differences in genetics, environment and lifestyles among individuals and making precise diseases classification and diagnosis, which can provide patients with personalized, targeted prevention and treatment. Large-scale population cohort studies are fundamental for precision medicine research, and could produce best evidence for precision medicine practices. Current criticisms on precision medicine mainly focus on the very small proportion of benefited patients, the neglect of social determinants for health, and the possible waste of limited medical resources. In spite of this, precision medicine is still a most hopeful research area, and would become a health care practice model in the future.

  1. Say No to Speed Bumps!

    ERIC Educational Resources Information Center

    Brannon, Sian

    2010-01-01

    No matter how cutting edge (and nicely funded) one's library is, there is always something cooler and more efficient on the horizon. Granted, not all new technology may be necessary in the library. But chances are one is going to want to get something--RFID (radio frequency identification), text reference, downloadable content, gaming,…

  2. Toward precise pulmonary nodule descriptors for nodule type classification.

    PubMed

    Farag, Amal; Elhabian, Shireen; Graham, James; Farag, Aly; Falk, Robert

    2010-01-01

    A framework for nodule feature-based extraction is presented to classify lung nodules in low-dose CT slices (LDCT) into four categories: juxta, well-circumscribed, vascularized and pleural-tail, based on the extracted information. The Scale Invariant Feature Transform (SIFT) and an adaptation to Daugman's Iris Recognition algorithm are used for analysis. The SIFT descriptor results are projected to lower-dimensional subspaces using PCA and LDA. Complex Gabor wavelet nodule response obtained from an adopted Daugman Iris Recognition algorithm revealed improvements from the original Daugman binary iris code. This showed that binarized nodule responses (codes) are inadequate for classification since nodules lack texture concentration as seen in the iris, while the SIFT algorithm projected using PCA showed robustness and precision in classification.

  3. Fluid extraction

    DOEpatents

    Wai, Chien M.; Laintz, Kenneth E.

    1999-01-01

    A method of extracting metalloid and metal species from a solid or liquid material by exposing the material to a supercritical fluid solvent containing a chelating agent is described. The chelating agent forms chelates that are soluble in the supercritical fluid to allow removal of the species from the material. In preferred embodiments, the extraction solvent is supercritical carbon dioxide and the chelating agent is a fluorinated .beta.-diketone. In especially preferred embodiments the extraction solvent is supercritical carbon dioxide, and the chelating agent comprises a fluorinated .beta.-diketone and a trialkyl phosphate, or a fluorinated .beta.-diketone and a trialkylphosphine oxide. Although a trialkyl phosphate can extract lanthanides and actinides from acidic solutions, a binary mixture comprising a fluorinated .beta.-diketone and a trialkyl phosphate or a trialkylphosphine oxide tends to enhance the extraction efficiencies for actinides and lanthanides. The method provides an environmentally benign process for removing contaminants from industrial waste without using acids or biologically harmful solvents. The method is particularly useful for extracting actinides and lanthanides from acidic solutions. The chelate and supercritical fluid can be regenerated, and the contaminant species recovered, to provide an economic, efficient process.

  4. Toward precision medicine in neurological diseases.

    PubMed

    Tan, Lin; Jiang, Teng; Tan, Lan; Yu, Jin-Tai

    2016-03-01

    Technological development has paved the way for accelerated genomic discovery and is bringing precision medicine into view. The goal of precision medicine is to deliver optimally targeted and timed interventions tailored to an individual's molecular drivers of disease. Neurological diseases are promisingly suited models for precision medicine because of the rapidly expanding genetic knowledge base, phenotypic classification, the development of biomarkers and the potential modifying treatments. Moving forward, it is crucial that through these integrated research platforms to provide analysis both for accurate personal genome analysis and gene and drug discovery. Here we describe our vision of how precision medicine can bring greater clarity to the clinical and biological complexity of neurological diseases.

  5. Precision injection molding of freeform optics

    NASA Astrophysics Data System (ADS)

    Fang, Fengzhou; Zhang, Nan; Zhang, Xiaodong

    2016-08-01

    Precision injection molding is the most efficient mass production technology for manufacturing plastic optics. Applications of plastic optics in field of imaging, illumination, and concentration demonstrate a variety of complex surface forms, developing from conventional plano and spherical surfaces to aspheric and freeform surfaces. It requires high optical quality with high form accuracy and lower residual stresses, which challenges both optical tool inserts machining and precision injection molding process. The present paper reviews recent progress in mold tool machining and precision injection molding, with more emphasis on precision injection molding. The challenges and future development trend are also discussed.

  6. Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

    2015-04-01

    We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). In this paper, we propose a method for extraction of the specific eccrine sweat gland by means of the connected component extraction process and the adaptive threshold method, where the en face OCT images are constructed by the swept-source OCT. In the experiment, we demonstrate precise measurement of the volume of the sweat gland in response to the external stimulus.

  7. Precision constraints on extra fermion generations.

    PubMed

    Erler, Jens; Langacker, Paul

    2010-07-16

    There has been recent renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak precision constraints, in particular, in the interpretation of several of the low energy experiments. We summarize the various motivations for extra families and analyze them in view of the latest electroweak precision data.

  8. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Precision attachment. 872.3165 Section 872.3165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75...

  9. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Precision attachment. 872.3165 Section 872.3165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75...

  10. Ultra-precision processes for optics manufacturing

    NASA Technical Reports Server (NTRS)

    Martin, William R.

    1991-01-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  11. Ultra-precision processes for optics manufacturing

    NASA Astrophysics Data System (ADS)

    Martin, William R.

    1991-12-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  12. Visual thread quality for precision miniature mechanisms

    SciTech Connect

    Gillespie, L.K.

    1981-04-01

    Threaded features have eight visual appearance factors which can affect their function in precision miniature mechanisms. The Bendix practice in deburring, finishing, and accepting these conditions on miniature threads is described as is their impact in assemblies of precision miniature electromechanical assemblies.

  13. Remote sensing applications to precision farming

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Traditional mechanized agriculture treats large fields with uniform agronomic practices. Precision agriculture/precision farming brings a new concept to manage in-field variability with variable rate application of fertilizers and pesticides, site-specific water management, as well as planting, etc....

  14. Precision Photometry of Long Period Variable Stars

    NASA Astrophysics Data System (ADS)

    Mais, D. E.; Bhatia, A.; Stencel, R. E.; Richards, D.

    2004-05-01

    Recently, evidence has been accumulating to suggest that Mira variables may go through flare up stages which result in brightening on the order of several tenths of a magnitude or more, and may last hours to days in length (Schaefer 1991, Maffei and Tosti 1995 and de Laverny 1998). Very little is known about these events, indeed it is not clear that these events are real. If they are real events, the spectroscopic changes, which occur during these flare-up episodes, remain relatively unexplored. This project was initiated in order to monitor a group of program stars of these classes in the V and R photometric bands in the hopes of "catching" some of these stars during these flare ups, thus offering confirmation to their reality and to be able to conduct spectral analysis of the flare-ups in real time and compare these spectra to the non-flare spectra. During the course of the past year, nearly 98 program stars have been monitored to address the potential flare up episodes. These include 25 M-type, 16-S type and 57 C-type Mira's. However, this more careful monitoring appears to not detect comparable behavior in similar stars near their minimum light, but rather exhibits a "Cepheid bump-like" phenomenon in several cases after minimum light, typically around phase 0.6-0.8 (cf. Melikian, 1999). Interpretation as an intermittent overtone pulsation is provided, and its effect on dust production discussed. We acknowledge support from the estate of William Herschel Womble, for the University of Denver astronomers participating in this effort.

  15. Space Technology 7 Disturbance Reduction System - precision control flight Validation

    NASA Technical Reports Server (NTRS)

    Carmain, Andrew J.; Dunn, Charles; Folkner, William; Hruby, Vlad; Spence, Doug; O'Donnell, James; Markley, Landis; Maghami, Peiman; Hsu, Oscar; Demmons, N.; Roy, T.; Gasdaska, C.; Young, J.; Connolly, W.; McCormick, R.; Gasdaska, C.

    2005-01-01

    The NASA New Millennium Program Space Technology 7 (ST7) project will validate technology for precision spacecraft control. The Disturbance Reduction System (DRS) will be part of the European Space Agency's LISA Pathfinder project. The DRS will control the position of the spacecraft relative to a reference to an accuracy of one nanometer over time scales of several thousand seconds. To perform the control, the spacecraft will use a new colloid thruster technology. The thrusters will operate over the range of 5 to 30 micro-Newtons with precision of 0.1 micro- Newton. The thrust will be generated by using a high electric field to extract charged droplets of a conducting colloid fluid and accelerating them with a precisely adjustable voltage. The control reference will be provided by the European LISA Technology Package, which will include two nearly freefloating test masses. The test mass positions and orientations will be measured using a capacitance bridge. The test mass position and attitude will be adjustable using electrostatically applied forces and torques. The DRS will control the spacecraft position with respect to one test mass while minimizing disturbances on the second test mass. The dynamic control system will cover eighteen degrees of freedom: six for each of the test masses and six for the spacecraft. After launch in late 2009 to a low Earth orbit, the LISA Pathfinder spacecraft will be maneuvered to a halo orbit about the Earth-Sun L1 Lagrange point for operations.

  16. Improve Radial Velocity Precision with Better Data Analysis Tools

    NASA Astrophysics Data System (ADS)

    Xuesong Wang, Sharon; Wright, Jason; Zhao, Ming

    2015-12-01

    The synergy between Kepler and the ground-based radial velocity (RV) surveys have made numerous discoveries of low-mass exoplanets, opening the age of Earth analogs. However, Earth analogs such as Kepler 452-b require a much higher RV precision ( ~ 10 cm/s) than the achievable with current instruments (~ 1 m/s) and understanding of stellar photosphere. This presentation will cover some of the instrumental and data issues that are currently hindering us from achieving the sub 1 m/s precision, as well as remedies and ways forward with future RV instruments. Highlights of our work include: (1) how telluric contamination affects RV precision and how to "telluric-proof" a Doppler pipeline; (2) how errors in the deconvolved stellar reference spectrum can mimic the signal of a super-Earth on a ~1 year orbit; (3) the battle with imperfections in the iodine reference spectra and how an ultra-high resolution (R ~ 500,000) echelle spectrum can help; (4) and a new RV extraction code in Python which incorporates MCMC and Gaussian Processes. This research is based on radial velocity data taken with iodine cell calibrators using Keck/HIRES and HET/HRS.

  17. Extractant composition

    DOEpatents

    Smith, Barbara F.; Jarvinen, Gordon D.; Ryan, Robert R.

    1990-01-01

    An organic extracting solution useful for separating elements of the actinide series of the periodic table from elements of the lanthanide series, where both are in trivalent form. The extracting solution consists of a primary ligand and a secondary ligand, preferably in an organic solvent. The primary ligand is a substituted monothio-1,3-dicarbonyl, which includes a substituted 4-acyl-2-pyrazolin-5-thione, such as 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT). The secondary ligand is a substituted phosphine oxide, such as trioctylphosphine oxide (TOPO).

  18. Statistical behavior analysis and precision optimization for the laser stripe center detector based on Steger's algorithm.

    PubMed

    Qi, Li; Zhang, Yixin; Zhang, Xuping; Wang, Shun; Xie, Fei

    2013-06-03

    Triangulation laser range scanning, which has been wildly used in various applications, can reconstruct the 3D geometric of the object with high precision by processing the image of laser stripe. The unbiased line extractor proposed by Steger is one of the most commonly used algorithms in laser stripe center extraction for its precision and robustness. Therefore, it is of great significance to assess the statistical performance of the Steger method when it is applied on laser stripe with Gaussian intensity profile. In this paper, a statistical behavior analysis for the laser stripe center extractor based on Steger method has been carried out. Relationships between center extraction precision, image quality and stripe characteristics have been examined analytically. Optimal scale of Gaussian smoothing kernel can be determined for each laser stripe image to achieve the highest precision according to the derived formula. Flexible three-step noise estimation procedure has been proposed to evaluate the center extraction precision of a typical triangulation laser scanning system by simply referring to the acquired images. The validity of our analysis has been verified by experiments on both artificial and natural images.

  19. Extractable resources

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The use of information from space systems in the operation of extractive industries, particularly in exploration for mineral and fuel resources was reviewed. Conclusions and recommendations reported are based on the fundamental premise that survival of modern industrial society requires a continuing secure flow of resources for energy, construction and manufacturing, and for use as plant foods.

  20. The Too-Much-Precision Effect.

    PubMed

    Loschelder, David D; Friese, Malte; Schaerer, Michael; Galinsky, Adam D

    2016-12-01

    Past research has suggested a fundamental principle of price precision: The more precise an opening price, the more it anchors counteroffers. The present research challenges this principle by demonstrating a too-much-precision effect. Five experiments (involving 1,320 experts and amateurs in real-estate, jewelry, car, and human-resources negotiations) showed that increasing the precision of an opening offer had positive linear effects for amateurs but inverted-U-shaped effects for experts. Anchor precision backfired because experts saw too much precision as reflecting a lack of competence. This negative effect held unless first movers gave rationales that boosted experts' perception of their competence. Statistical mediation and experimental moderation established the critical role of competence attributions. This research disentangles competing theoretical accounts (attribution of competence vs. scale granularity) and qualifies two putative truisms: that anchors affect experts and amateurs equally, and that more precise prices are linearly more potent anchors. The results refine current theoretical understanding of anchoring and have significant implications for everyday life.

  1. Toward precision medicine in Alzheimer's disease.

    PubMed

    Reitz, Christiane

    2016-03-01

    In Western societies, Alzheimer's disease (AD) is the most common form of dementia and the sixth leading cause of death. In recent years, the concept of precision medicine, an approach for disease prevention and treatment that is personalized to an individual's specific pattern of genetic variability, environment and lifestyle factors, has emerged. While for some diseases, in particular select cancers and a few monogenetic disorders such as cystic fibrosis, significant advances in precision medicine have been made over the past years, for most other diseases precision medicine is only in its beginning. To advance the application of precision medicine to a wider spectrum of disorders, governments around the world are starting to launch Precision Medicine Initiatives, major efforts to generate the extensive scientific knowledge needed to integrate the model of precision medicine into every day clinical practice. In this article we summarize the state of precision medicine in AD, review major obstacles in its development, and discuss its benefits in this highly prevalent, clinically and pathologically complex disease.

  2. [Precision Nursing: Individual-Based Knowledge Translation].

    PubMed

    Chiang, Li-Chi; Yeh, Mei-Ling; Su, Sui-Lung

    2016-12-01

    U.S. President Obama announced a new era of precision medicine in the Precision Medicine Initiative (PMI). This initiative aims to accelerate the progress of personalized medicine in light of individual requirements for prevention and treatment in order to improve the state of individual and public health. The recent and dramatic development of large-scale biologic databases (such as the human genome sequence), powerful methods for characterizing patients (such as genomics, microbiome, diverse biomarkers, and even pharmacogenomics), and computational tools for analyzing big data are maximizing the potential benefits of precision medicine. Nursing science should follow and keep pace with this trend in order to develop empirical knowledge and expertise in the area of personalized nursing care. Nursing scientists must encourage, examine, and put into practice innovative research on precision nursing in order to provide evidence-based guidance to clinical practice. The applications in personalized precision nursing care include: explanations of personalized information such as the results of genetic testing; patient advocacy and support; anticipation of results and treatment; ongoing chronic monitoring; and support for shared decision-making throughout the disease trajectory. Further, attention must focus on the family and the ethical implications of taking a personalized approach to care. Nurses will need to embrace the paradigm shift to precision nursing and work collaboratively across disciplines to provide the optimal personalized care to patients. If realized, the full potential of precision nursing will provide the best chance for good health for all.

  3. Precision half-life measurement of 17F

    NASA Astrophysics Data System (ADS)

    Brodeur, M.; Nicoloff, C.; Ahn, T.; Allen, J.; Bardayan, D. W.; Becchetti, F. D.; Gupta, Y. K.; Hall, M. R.; Hall, O.; Hu, J.; Kelly, J. M.; Kolata, J. J.; Long, J.; O'Malley, P.; Schultz, B. E.

    2016-02-01

    Background: The precise determination of f t values for superallowed mixed transitions between mirror nuclide are gaining attention as they could provide an avenue to test the theoretical corrections used to extract the Vu d matrix element from superallowed pure Fermi transitions. The 17F decay is particularly interesting as it proceeds completely to the ground state of 17O, removing the need for branching ratio measurements. The dominant uncertainty on the f t value of the 17F mirror transition stems from a number of conflicting half-life measurements. Purpose: A precision half-life measurement of 17F was performed and compared to previous results. Methods: The life-time was determined from the β counting of implanted 17F on a Ta foil that was removed from the beam for counting. The 17F beam was produced by transfers reaction and separated by the TwinSol facility of the Nuclear Science Laboratory of the University of Notre Dame. Results: The measured value of t1/2 new=64.402 (42) s is in agreement with several past measurements and represents one of the most precise measurements to date. In anticipation of future measurements of the correlation parameters for the decay and using the new world average t1/2 world=64.398 (61) s, we present a new estimate of the mixing ratio ρ for the mixed transition as well as the correlation parameters based on assuming Standard Model validity. Conclusions: The relative uncertainty on the new world average for the half-life is dominated by the large χ2=31 of the existing measurements. More precision measurements with different systematics are needed to remedy to the situation.

  4. Mixed-Precision Spectral Deferred Correction: Preprint

    SciTech Connect

    Grout, Ray W. S.

    2015-09-02

    Convergence of spectral deferred correction (SDC), where low-order time integration methods are used to construct higher-order methods through iterative refinement, can be accelerated in terms of computational effort by using mixed-precision methods. Using ideas from multi-level SDC (in turn based on FAS multigrid ideas), some of the SDC correction sweeps can use function values computed in reduced precision without adversely impacting the accuracy of the final solution. This is particularly beneficial for the performance of combustion solvers such as S3D [6] which require double precision accuracy but are performance limited by the cost of data motion.

  5. The forthcoming era of precision medicine.

    PubMed

    Gamulin, Stjepan

    2016-11-01

    The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application. The implementation of precision medicine in health care requires the coordinated efforts of all health care stakeholders (the biomedical community, government, regulatory bodies, patients' groups). Particularly, translational research with the integration of genomic and comprehensive data from all levels of the organism ("big data"), development of bioinformatics platforms enabling network analysis of disease etiopathogenesis, development of a legislative framework for handling personal data, and new paradigms of medical education are necessary for successful application of the concept of precision medicine in health care.

  6. Precision measurement for particle physics and cosmology

    NASA Astrophysics Data System (ADS)

    Graham, Peter

    2017-01-01

    Axions and other light particles are strongly motivated. For example, the axion is the crucial element in the recently proposed solution to the hierarchy problem using dynamical relaxation in the early universe. However, such particles are challenging to search for experimentally. Precision measurement technologies such as atom interferometry, nuclear magnetic resonance, high precision magnetometry, and torsion balances allow novel, highly sensitive experiments for direct detection of such light dark matter and of gravitational waves. Thus precision measurement technologies open new avenues for probing the origin and composition of the universe.

  7. Methods for high precision 14C AMS measurement of atmospheric CO2 at LLNL

    SciTech Connect

    Graven, H D; Guilderson, T P; Keeling, R F

    2006-10-18

    Development of {sup 14}C analysis with precision better than 2{per_thousand} has the potential to expand the utility of {sup 14}CO{sub 2} measurements for carbon cycle investigations as atmospheric gradients currently approach traditional measurement precision of 2-5{per_thousand}. The AMS facility at the Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, produces high and stable beam currents that enable efficient acquisition times for large numbers of {sup 14}C counts. One million {sup 14}C atoms can be detected in approximately 25 minutes, suggesting that near 1{per_thousand} counting precision is economically feasible at LLNL. The overall uncertainty in measured values is ultimately determined by the variation between measured ratios in several sputtering periods of the same sample and by the reproducibility of replicate samples. Experiments on the collection of one million counts on replicate samples of CO{sub 2} extracted from a whole air cylinder show a standard deviation of 1.7{per_thousand} in 36 samples measured over several wheels. This precision may be limited by the reproducibility of Oxalic Acid I standard samples, which is considerably poorer. We outline the procedures for high-precision sample handling and analysis that have enabled reproducibility in the cylinder extraction samples at the <2{per_thousand} level and describe future directions to continue increasing measurement precision at LLNL.

  8. Precision mechatronics based on high-precision measuring and positioning systems and machines

    NASA Astrophysics Data System (ADS)

    Jäger, Gerd; Manske, Eberhard; Hausotte, Tino; Mastylo, Rostyslav; Dorozhovets, Natalja; Hofmann, Norbert

    2007-06-01

    Precision mechatronics is defined in the paper as the science and engineering of a new generation of high precision systems and machines. Nanomeasuring and nanopositioning engineering represents important fields of precision mechatronics. The nanometrology is described as the today's limit of the precision engineering. The problem, how to design nanopositioning machines with uncertainties as small as possible will be discussed. The integration of several optical and tactile nanoprobes makes the 3D-nanopositioning machine suitable for various tasks, such as long range scanning probe microscopy, mask and wafer inspection, nanotribology, nanoindentation, free form surface measurement as well as measurement of microoptics, precision molds, microgears, ring gauges and small holes.

  9. Precision controllability of the F-15 airplane

    NASA Technical Reports Server (NTRS)

    Sisk, T. R.; Matheny, N. W.

    1979-01-01

    A flying qualities evaluation conducted on a preproduction F-15 airplane permitted an assessment to be made of its precision controllability in the high subsonic and low transonic flight regime over the allowable angle of attack range. Precision controllability, or gunsight tracking, studies were conducted in windup turn maneuvers with the gunsight in the caged pipper mode and depressed 70 mils. This evaluation showed the F-15 airplane to experience severe buffet and mild-to-moderate wing rock at the higher angles of attack. It showed the F-15 airplane radial tracking precision to vary from approximately 6 to 20 mils over the load factor range tested. Tracking in the presence of wing rock essentially doubled the radial tracking error generated at the lower angles of attack. The stability augmentation system affected the tracking precision of the F-15 airplane more than it did that of previous aircraft studied.

  10. 21 CFR 872.3165 - Precision attachment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75 percent or greater gold and metals of the platinum group intended for use in prosthetic dentistry...

  11. Courseware Review: Vernier Software: Precision Timer II.

    ERIC Educational Resources Information Center

    Park, John C.

    1988-01-01

    Reviews "Vernier Software: Precision Timer II" for high school through college mechanics. Introduces 14 different modes including pulse time, pendulum timer, bouncer timer, gate timer, collision timers, and stroke calibration. Provides two typical displays and ratings of the software. (YP)

  12. Prospects for Precision Neutrino Cross Section Measurements

    SciTech Connect

    Harris, Deborah A.

    2016-01-28

    The need for precision cross section measurements is more urgent now than ever before, given the central role neutrino oscillation measurements play in the field of particle physics. The definition of precision is something worth considering, however. In order to build the best model for an oscillation experiment, cross section measurements should span a broad range of energies, neutrino interaction channels, and target nuclei. Precision might better be defined not in the final uncertainty associated with any one measurement but rather with the breadth of measurements that are available to constrain models. Current experience shows that models are better constrained by 10 measurements across different processes and energies with 10% uncertainties than by one measurement of one process on one nucleus with a 1% uncertainty. This article describes the current status of and future prospects for the field of precision cross section measurements considering the metric of how many processes, energies, and nuclei have been studied.

  13. Nucleon measurements at the precision frontier

    SciTech Connect

    Carlson, Carl E.

    2013-11-07

    We comment on nucleon measurements at the precision frontier. As examples of what can be learned, we concentrate on three topics, which are parity violating scattering experiments, the proton radius puzzle, and the symbiosis between nuclear and atomic physics.

  14. Toward precision medicine in neurological diseases

    PubMed Central

    Tan, Lin; Jiang, Teng

    2016-01-01

    Technological development has paved the way for accelerated genomic discovery and is bringing precision medicine into view. The goal of precision medicine is to deliver optimally targeted and timed interventions tailored to an individual’s molecular drivers of disease. Neurological diseases are promisingly suited models for precision medicine because of the rapidly expanding genetic knowledge base, phenotypic classification, the development of biomarkers and the potential modifying treatments. Moving forward, it is crucial that through these integrated research platforms to provide analysis both for accurate personal genome analysis and gene and drug discovery. Here we describe our vision of how precision medicine can bring greater clarity to the clinical and biological complexity of neurological diseases. PMID:27127757

  15. Precision Engineering within the National Ignition Campaign

    SciTech Connect

    Taylor, J S; Carlisle, K; Klingmann, J L; Geraghty, P; Saito, T T; Montesanti, R C

    2010-02-17

    In this very brief talk, we'll discuss how precision engineering impacts 4 key areas of NIF: (1) Diamond turning of KDP crystals; (2) Mitigation of laser damage on optics; (3) Alignment of lasers, targets, diagnostics; (4) Target fabrication.

  16. The role of precise time in IFF

    NASA Technical Reports Server (NTRS)

    Bridge, W. M.

    1982-01-01

    The application of precise time to the identification of friend or foe (IFF) problem is discussed. The simple concept of knowing when to expect each signal is exploited in a variety of ways to achieve an IFF system which is hard to detect, minimally exploitable and difficult to jam. Precise clocks are the backbone of the concept and the various candidates for this role are discussed. The compact rubidium-controlled oscillator is the only practical candidate.

  17. Towards precision spectroscopy of baryonic resonances

    DOE PAGES

    Doring, Michael; Mai, Maxim; Ronchen, Deborah

    2017-01-26

    Recent progress in baryon spectroscopy is reviewed. In a common effort, various groups have analyzed a set of new high-precision polarization observables from ELSA. The Julich-Bonn group has finalized the analysis of pion-induced meson-baryon production, the potoproduction of pions and eta mesons, and (almost) the KΛ final state. Lastly, as data become preciser, statistical aspects in the analysis of excited baryons become increasingly relevant and several advances in this direction are proposed.

  18. Precise predictions for slepton pair production

    SciTech Connect

    Ayres Freitas; Andreas von Manteuffel

    2002-11-07

    At a future linear collider, the masses and couplings of scalar leptons can be measured with high accuracy, thus requiring precise theoretical predictions for the relevant processes. In this work, after a discussion of the expected experimental precision, the complete one-loop corrections to smuon and selectron pair production in the MSSM are presented and the effect of different contributions in the result is analyzed.

  19. A path to precision in the ICU.

    PubMed

    Maslove, David M; Lamontagne, Francois; Marshall, John C; Heyland, Daren K

    2017-04-03

    Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justifications for the adoption of a precision approach to research and practice. Inherently protean diseases states such as sepsis and acute respiratory distress syndrome have manifestations that are physiologically and anatomically diffuse, and that fluctuate over short periods of time. This leads to considerable heterogeneity among patients, and conditions in which a "one size fits all" approach to therapy can lead to widely divergent results. Current ICU therapy can thus be seen as imprecise, with the potential to realize substantial gains from the adoption of precision medicine approaches. A number of challenges still face the development and adoption of precision critical care, a transition that may occur incrementally rather than wholesale. This article describes a few concrete approaches to addressing these challenges.First, novel clinical trial designs, including registry randomized controlled trials and platform trials, suggest ways in which conventional trials can be adapted to better accommodate the physiologic heterogeneity of critical illness. Second, beyond the "omics" technologies already synonymous with precision medicine, the data-rich environment of the ICU can generate complex physiologic signatures that could fuel precision-minded research and practice. Third, the role of computing infrastructure and modern informatics methods will be central to the pursuit of precision medicine in the ICU, necessitating close collaboration with data scientists. As work toward precision critical care continues, small proof-of-concept studies may prove useful in highlighting the potential of this approach.

  20. High-precision arithmetic in mathematical physics

    DOE PAGES

    Bailey, David H.; Borwein, Jonathan M.

    2015-05-12

    For many scientific calculations, particularly those involving empirical data, IEEE 32-bit floating-point arithmetic produces results of sufficient accuracy, while for other applications IEEE 64-bit floating-point is more appropriate. But for some very demanding applications, even higher levels of precision are often required. Furthermore, this article discusses the challenge of high-precision computation, in the context of mathematical physics, and highlights what facilities are required to support future computation, in light of emerging developments in computer architecture.

  1. Principles of precision medicine in stroke.

    PubMed

    Hinman, Jason D; Rost, Natalia S; Leung, Thomas W; Montaner, Joan; Muir, Keith W; Brown, Scott; Arenillas, Juan F; Feldmann, Edward; Liebeskind, David S

    2017-01-01

    The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health. Existing data may be leveraged with novel technologies, informatics and practical clinical paradigms to apply these principles in stroke and realise the promise of precision medicine. Importantly, precision medicine in stroke will only be realised once efforts to collect, value and synthesise the wealth of data collected in clinical trials and routine care starts. Stroke theranostics, the ultimate vision of synchronising tailored therapeutic strategies based on specific diagnostic data, demand cerebrovascular expertise on big data approaches to clinically relevant paradigms. This review considers such challenges and delineates the principles on a roadmap for rational application of precision medicine to stroke and cerebrovascular health.

  2. Platform Precision Autopilot Overview and Mission Performance

    NASA Technical Reports Server (NTRS)

    Strovers, Brian K.; Lee, James A.

    2009-01-01

    The Platform Precision Autopilot is an instrument landing system-interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Unmanned Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

  3. The Paradox of Abstraction: Precision Versus Concreteness.

    PubMed

    Iliev, Rumen; Axelrod, Robert

    2016-11-22

    We introduce a novel measure of abstractness based on the amount of information of a concept computed from its position in a semantic taxonomy. We refer to this measure as precision. We propose two alternative ways to measure precision, one based on the path length from a concept to the root of the taxonomic tree, and another one based on the number of direct and indirect descendants. Since more information implies greater processing load, we hypothesize that nouns higher in precision will have a processing disadvantage in a lexical decision task. We contrast precision to concreteness, a common measure of abstractness based on the proportion of sensory-based information associated with a concept. Since concreteness facilitates cognitive processing, we predict that while both concreteness and precision are measures of abstractness, they will have opposite effects on performance. In two studies we found empirical support for our hypothesis. Precision and concreteness had opposite effects on latency and accuracy in a lexical decision task, and these opposite effects were observable while controlling for word length, word frequency, affective content and semantic diversity. Our results support the view that concepts organization includes amodal semantic structures which are independent of sensory information. They also suggest that we should distinguish between sensory-based and amount-of-information-based abstractness.

  4. Toward precision medicine in Parkinson's disease.

    PubMed

    Bu, Lu-Lu; Yang, Ke; Xiong, Wei-Xi; Liu, Feng-Tao; Anderson, Boyd; Wang, Ye; Wang, Jian

    2016-01-01

    Precision medicine refers to an innovative approach selected for disease prevention and health promotion according to the individual characteristics of each patient. The goal of precision medicine is to formulate prevention and treatment strategies based on each individual with novel physiological and pathological insights into a certain disease. A multidimensional data-driven approach is about to upgrade "precision medicine" to a higher level of greater individualization in healthcare, a shift towards the treatment of individual patients rather than treating a certain disease including Parkinson's disease (PD). As one of the most common neurodegenerative diseases, PD is a lifelong chronic disease with clinical and pathophysiologic complexity, currently it is treatable but neither preventable nor curable. At its advanced stage, PD is associated with devastating chronic complications including both motor dysfunction and non-motor symptoms which impose an immense burden on the life quality of patients. Advances in computational approaches provide opportunity to establish the patient's personalized disease data at the multidimensional levels, which finally meeting the need for the current concept of precision medicine via achieving the minimal side effects and maximal benefits individually. Hence, in this review, we focus on highlighting the perspectives of precision medicine in PD based on multi-dimensional information about OMICS, molecular imaging, deep brain stimulation (DBS) and wearable sensors. Precision medicine in PD is expected to integrate the best evidence-based knowledge to individualize optimal management in future health care for those with PD.

  5. Precision oncology: origins, optimism, and potential.

    PubMed

    Prasad, Vinay; Fojo, Tito; Brada, Michael

    2016-02-01

    Imatinib, the first and arguably the best targeted therapy, became the springboard for developing drugs aimed at molecular targets deemed crucial to tumours. As this development unfolded, a revolution in the speed and cost of genetic sequencing occurred. The result--an armamentarium of drugs and an array of molecular targets--set the stage for precision oncology, a hypothesis that cancer treatment could be markedly improved if therapies were guided by a tumour's genomic alterations. Drawing lessons from the biological basis of cancer and recent empirical investigations, we take a more measured view of precision oncology's promise. Ultimately, the promise is not our concern, but the threshold at which we declare success. We review reports of precision oncology alongside those of precision diagnostics and novel radiotherapy approaches. Although confirmatory evidence is scarce, these interventions have been widely endorsed. We conclude that the current path will probably not be successful or, at a minimum, will have to undergo substantive adjustments before it can be successful. For the sake of patients with cancer, we hope one form of precision oncology will deliver on its promise. However, until confirmatory studies are completed, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing.

  6. Precision diabetes: learning from monogenic diabetes.

    PubMed

    Hattersley, Andrew T; Patel, Kashyap A

    2017-05-01

    The precision medicine approach of tailoring treatment to the individual characteristics of each patient or subgroup has been a great success in monogenic diabetes subtypes, MODY and neonatal diabetes. This review examines what has led to the success of a precision medicine approach in monogenic diabetes (precision diabetes) and outlines possible implications for type 2 diabetes. For monogenic diabetes, the molecular genetics can define discrete aetiological subtypes that have profound implications on diabetes treatment and can predict future development of associated clinical features, allowing early preventative or supportive treatment. In contrast, type 2 diabetes has overlapping polygenic susceptibility and underlying aetiologies, making it difficult to define discrete clinical subtypes with a dramatic implication for treatment. The implementation of precision medicine in neonatal diabetes was simple and rapid as it was based on single clinical criteria (diagnosed <6 months of age). In contrast, in MODY it was more complex and slow because of the lack of single criteria to identify patients, but it was greatly assisted by the development of a diagnostic probability calculator and associated smartphone app. Experience in monogenic diabetes suggests that successful adoption of a precision diabetes approach in type 2 diabetes will require simple, quick, easily accessible stratification that is based on a combination of routine clinical data, rather than relying on newer technologies. Analysing existing clinical data from routine clinical practice and trials may provide early success for precision medicine in type 2 diabetes.

  7. URANIUM EXTRACTION

    DOEpatents

    Harrington, C.D.; Opie, J.V.

    1958-07-01

    The recovery of uranium values from uranium ore such as pitchblende is described. The ore is first dissolved in nitric acid, and a water soluble nitrate is added as a salting out agent. The resulting feed solution is then contacted with diethyl ether, whereby the bulk of the uranyl nitrate and a portion of the impurities are taken up by the ether. This acid ether extract is then separated from the aqueous raffinate, and contacted with water causing back extractioa of the uranyl nitrate and impurities into the water to form a crude liquor. After separation from the ether extract, this crude liquor is heated to about 118 deg C to obtain molten uranyl nitrate hexahydratc. After being slightly cooled the uranyl nitrate hexahydrate is contacted with acid free diethyl ether whereby the bulk of the uranyl nitrate is dissolved into the ethcr to form a neutral ether solution while most of the impurities remain in the aqueous waste. After separation from the aqueous waste, the resultant ether solution is washed with about l0% of its volume of water to free it of any dissolved impurities and is then contacted with at least one half its volume of water whereby the uranyl nitrate is extracted into the water to form an aqueous product solution.

  8. Doppler extraction with a digital VCO

    NASA Technical Reports Server (NTRS)

    Starner, E. R.; Nossen, E. J.

    1977-01-01

    Digitally controlled oscillator in phased-locked loop may be useful for data communications systems, or may be modified to serve as information extraction component of microwave or optical system for collision avoidance or automatic braking. Instrument is frequency-synthesizing device with output specified precisely by digital number programmed into frequency register.

  9. Contrasting Extraction Types.

    ERIC Educational Resources Information Center

    Postal, Paul M.

    1994-01-01

    This paper grounds a novel typology yielding three major types of English (L(eft)-extraction, defined by their relationship to resumptive pronouns (RPs): (1) B-extractions, which require RPs in their extraction sites, (2) A1-extractions, which allow RPs in their extraction sites, and (3) A2-extractions, which forbid RPs in their extraction sites.…

  10. Conducting Precision Medicine Research with African Americans

    PubMed Central

    Halbert, Chanita Hughes; McDonald, Jasmine; Vadaparampil, Susan; Rice, LaShanta; Jefferson, Melanie

    2016-01-01

    Importance Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. Objective It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Design, Setting, Participants Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Main Outcome Measure Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. Results One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). Conclusion and Relevance African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities. PMID:27441706

  11. Principles and techniques for designing precision machines

    SciTech Connect

    Hale, Layton Carter

    1999-02-01

    This thesis is written to advance the reader's knowledge of precision-engineering principles and their application to designing machines that achieve both sufficient precision and minimum cost. It provides the concepts and tools necessary for the engineer to create new precision machine designs. Four case studies demonstrate the principles and showcase approaches and solutions to specific problems that generally have wider applications. These come from projects at the Lawrence Livermore National Laboratory in which the author participated: the Large Optics Diamond Turning Machine, Accuracy Enhancement of High- Productivity Machine Tools, the National Ignition Facility, and Extreme Ultraviolet Lithography. Although broad in scope, the topics go into sufficient depth to be useful to practicing precision engineers and often fulfill more academic ambitions. The thesis begins with a chapter that presents significant principles and fundamental knowledge from the Precision Engineering literature. Following this is a chapter that presents engineering design techniques that are general and not specific to precision machines. All subsequent chapters cover specific aspects of precision machine design. The first of these is Structural Design, guidelines and analysis techniques for achieving independently stiff machine structures. The next chapter addresses dynamic stiffness by presenting several techniques for Deterministic Damping, damping designs that can be analyzed and optimized with predictive results. Several chapters present a main thrust of the thesis, Exact-Constraint Design. A main contribution is a generalized modeling approach developed through the course of creating several unique designs. The final chapter is the primary case study of the thesis, the Conceptual Design of a Horizontal Machining Center.

  12. Motor cortical function and the precision grip.

    PubMed

    Geevasinga, Nimeshan; Menon, Parvathi; Kiernan, Matthew C; Vucic, Steve

    2014-12-01

    While task-dependent changes in motor cortical outputs have been previously reported, the issue of whether such changes are specific for complex hand tasks remains unresolved. The aim of the present study was to determine whether cortical inhibitory tone and cortical output were greater during precision grip and power grip. Motor cortex excitability was undertaken by using the transcranial magnetic stimulation threshold tracking technique in 15 healthy subjects. The motor-evoked potential (MEP) responses were recorded over the abductor pollicis brevis (APB), with the hand in the following positions: (1) rest, (2) precision grip and (3) power grip. The MEP amplitude (MEP amplitude REST 23.6 ± 3.3%; MEP amplitude PRECISION GRIP 35.2 ± 5.6%; MEP amplitude POWER GRIP 19.6 ± 3.4%, F = 2.4, P < 0.001) and stimulus-response gradient (SLOPEREST 0.06 ± 0.01; SLOPEPRCISION GRIP 0.15 ± 0.04; SLOPE POWER GRIP 0.07 ± 0.01, P < 0.05) were significantly increased during precision grip. Short interval intracortical inhibition (SICI) was significantly reduced during the precision grip (SICI REST 15.0 ± 2.3%; SICI PRECISION GRIP 9.7 ± 1.5%, SICI POWER GRIP 15.9 ± 2.7%, F = 2.6, P < 0.05). The present study suggests that changes in motor cortex excitability are specific for precision grip, with functional coupling of descending corticospinal pathways controlling thumb and finger movements potentially forming the basis of these cortical changes.

  13. Apparatus for precision micromachining with lasers

    DOEpatents

    Chang, J.J.; Dragon, E.P.; Warner, B.E.

    1998-04-28

    A new material processing apparatus using a short-pulsed, high-repetition-rate visible laser for precision micromachining utilizes a near diffraction limited laser, a high-speed precision two-axis tilt-mirror for steering the laser beam, an optical system for either focusing or imaging the laser beam on the part, and a part holder that may consist of a cover plate and a back plate. The system is generally useful for precision drilling, cutting, milling and polishing of metals and ceramics, and has broad application in manufacturing precision components. Precision machining has been demonstrated through percussion drilling and trepanning using this system. With a 30 W copper vapor laser running at multi-kHz pulse repetition frequency, straight parallel holes with size varying from 500 microns to less than 25 microns and with aspect ratios up to 1:40 have been consistently drilled with good surface finish on a variety of metals. Micromilling and microdrilling on ceramics using a 250 W copper vapor laser have also been demonstrated with good results. Materialographic sections of machined parts show little (submicron scale) recast layer and heat affected zone. 1 fig.

  14. Apparatus for precision micromachining with lasers

    DOEpatents

    Chang, Jim J.; Dragon, Ernest P.; Warner, Bruce E.

    1998-01-01

    A new material processing apparatus using a short-pulsed, high-repetition-rate visible laser for precision micromachining utilizes a near diffraction limited laser, a high-speed precision two-axis tilt-mirror for steering the laser beam, an optical system for either focusing or imaging the laser beam on the part, and a part holder that may consist of a cover plate and a back plate. The system is generally useful for precision drilling, cutting, milling and polishing of metals and ceramics, and has broad application in manufacturing precision components. Precision machining has been demonstrated through percussion drilling and trepanning using this system. With a 30 W copper vapor laser running at multi-kHz pulse repetition frequency, straight parallel holes with size varying from 500 microns to less than 25 microns and with aspect ratios up to 1:40 have been consistently drilled with good surface finish on a variety of metals. Micromilling and microdrilling on ceramics using a 250 W copper vapor laser have also been demonstrated with good results. Materialogroaphic sections of machined parts show little (submicron scale) recast layer and heat affected zone.

  15. Precision distances with spiral galaxy apparent diameters

    NASA Astrophysics Data System (ADS)

    Steer, Ian

    2016-01-01

    Spiral galaxy diameters offer the oldest extragalactic distance indicator known. Although outdated and hitherto imprecise, two spiral diameter-based distance indicators applied in the 1980s can be tested, calibrated, and re-established for precision era use, based on abundant redshift-independent distances data available in NED-D. Indicator one employs the largest Giant Spiral Galaxies, which have an absolute isophotal major diameter of ~70 +/- 10 kpc, offering standard ruler-based distances with <10% precision. Indicator two employs the diameter-magnitude relation for spirals in general, as a secondary indicator, offering ~20% precision. The ruler-based indicator is the only indicator with <10% precision able to independently calibrate type Ia supernovae-based distances at cosmological distances. The secondary-based indicator is the only indicator with 20% precision applicable to more galaxies than in current Tully-Fisher surveys. The primary indicator gives researchers a new tool to confirm or refute if, as currently believed, universal expansion is accelerating. The secondary indicator gives researchers a new path toward acquiring a more complete 3D picture of the local universe and potentially, because the majority of galaxies in the universe are spirals, the distant universe.

  16. Toward Precision Healthcare: Context and Mathematical Challenges

    PubMed Central

    Colijn, Caroline; Jones, Nick; Johnston, Iain G.; Yaliraki, Sophia; Barahona, Mauricio

    2017-01-01

    Precision medicine refers to the idea of delivering the right treatment to the right patient at the right time, usually with a focus on a data-centered approach to this task. In this perspective piece, we use the term “precision healthcare” to describe the development of precision approaches that bridge from the individual to the population, taking advantage of individual-level data, but also taking the social context into account. These problems give rise to a broad spectrum of technical, scientific, policy, ethical and social challenges, and new mathematical techniques will be required to meet them. To ensure that the science underpinning “precision” is robust, interpretable and well-suited to meet the policy, ethical and social questions that such approaches raise, the mathematical methods for data analysis should be transparent, robust, and able to adapt to errors and uncertainties. In particular, precision methodologies should capture the complexity of data, yet produce tractable descriptions at the relevant resolution while preserving intelligibility and traceability, so that they can be used by practitioners to aid decision-making. Through several case studies in this domain of precision healthcare, we argue that this vision requires the development of new mathematical frameworks, both in modeling and in data analysis and interpretation. PMID:28377724

  17. High-precision laser machining of ceramics

    NASA Astrophysics Data System (ADS)

    Toenshoff, Hans K.; von Alvensleben, Ferdinand; Graumann, Christoph; Willmann, Guido

    1998-09-01

    The increasing demand for highly developed ceramic materials for various applications calls for innovative machining technologies yielding high accuracy and efficiency. Associated problems with conventional, i.e. mechanical methods, are unacceptable tool wear as well as force induced damages on ceramic components. Furthermore, the established grinding techniques often meet their limits if accurate complex 2D or 3D structures are required. In contrast to insufficient mechanical processes, UV-laser precision machining of ceramics offers not only a valuable technological alternative but a considerable economical aspect as well. In particular, excimer lasers provide a multitude of advantages for applications in high precision and micro technology. Within the UV wavelength range and pulses emitted in the nano-second region, minimal thermal effects on ceramics and polymers are observed. Thus, the ablation geometry can be controlled precisely in the lateral and vertical directions. In this paper, the excimer laser machining technology developed at the Laser Zentrum Hannover is explained. Representing current and future industrial applications, examinations concerning the precision cutting of alumina (Al2O3), and HF-composite materials, the ablation of ferrite ceramics for precision inductors and the structuring of SiC sealing and bearing rings are presented.

  18. Precise timing when hitting falling balls

    PubMed Central

    Brenner, Eli; Driesen, Ben; Smeets, Jeroen B. J.

    2014-01-01

    People are extremely good at hitting falling balls with a baseball bat. Despite the ball's constant acceleration, they have been reported to time hits with a standard deviation of only about 7 ms. To examine how people achieve such precision, we compared performance when there were no added restrictions, with performance when looking with one eye, when vision was blurred, and when various parts of the ball's trajectory were hidden from view. We also examined how the size of the ball and varying the height from which it was dropped influenced temporal precision. Temporal precision did not become worse when vision was blurred, when the ball was smaller, or when balls falling from different heights were randomly interleaved. The disadvantage of closing one eye did not exceed expectations from removing one of two independent estimates. Precision was higher for slower balls, but only if the ball being slower meant that one saw it longer before the hit. It was particularly important to see the ball while swinging the bat. Together, these findings suggest that people time their hits so precisely by using the changing elevation throughout the swing to adjust the bat's movement to that of the ball. PMID:24904380

  19. Stability precision dynamic testing system on artillery

    NASA Astrophysics Data System (ADS)

    Wang, Chunyan; Li, Bo

    2014-12-01

    Dynamic feature of Weapon equipments is one of important performance index for evaluating the performance of the whole weapon system. The construction of target range in our country in fire control dynamic testing is relatively backward; therefore, it has greatly influenced the evaluation on the fire control system. In order to solve this problem, it's urgent to develop a new testing instrument so as to adjust to the armament research process and promote weapon system working more efficiently and thereby meeting the needs of modernization in national defense. This paper proposes a new measure which is used to test the stability precision of the fire control system, and it is installed on the moving base. Using the method, we develop a testing system which can test the stability precision of the fire control system and achieve a high precision results after testing. The innovation of the system is we can receive the image not only by CCD, but our eyes. It also adopts digital image-forming and image processing technique for real-time measurement and storing of the target information; it simultaneously adopts the method adjusting the platform and the corresponding fixture mounted on a sample to measure the stable precision and the precision of corner of stabilizator. In this paper, we make a description on the construction of the system and the idea of the designing of the optical system. Finally, we introduce the actual application of the system and testing results.

  20. Aging affects neural precision of speech encoding

    PubMed Central

    Anderson, Samira; Parbery-Clark, Alexandra; White-Schwoch, Travis; Kraus, Nina

    2012-01-01

    Older adults frequently report they can hear what is said but cannot understand the meaning, especially in noise. This difficulty may arise from the inability to process rapidly changing elements of speech. Aging is accompanied by a general slowing of neural processing and decreased neural inhibition, both of which likely interfere with temporal processing in auditory and other sensory domains. Age-related reductions in inhibitory neurotransmitter levels and delayed neural recovery can contribute to decreases in the auditory system’s temporal precision. Decreased precision may lead to neural timing delays, reductions in neural response magnitude, and a disadvantage in processing the rapid acoustic changes in speech. The auditory brainstem response (ABR), a scalp-recorded electrical potential, is known for its ability to capture precise neural synchrony within subcortical auditory nuclei; therefore, we hypothesized that a loss of temporal precision results in subcortical timing delays and decreases in response consistency and magnitude. To assess this hypothesis, we recorded ABRs to the speech syllable /da/ in normal hearing younger (ages 18 to 30) and older adult humans (60 to 67). Older adults had delayed ABRs, especially in response to the rapidly changing formant transition, and greater response variability. We also found that older adults had decreased phase locking and smaller response magnitudes than younger adults. Taken together, our results support the theory that older adults have a loss of temporal precision in subcortical encoding of sound, which may account, at least in part, for their difficulties with speech perception. PMID:23055485

  1. Precise determination of the unperturbed 8B neutrino spectrum.

    PubMed

    Roger, T; Büscher, J; Bastin, B; Kirsebom, O S; Raabe, R; Alcorta, M; Äystö, J; Borge, M J G; Carmona-Gallardo, M; Cocolios, T E; Cruz, J; Dendooven, P; Fraile, L M; Fynbo, H O U; Galaviz, D; Gasques, L R; Giri, G S; Huyse, M; Hyldegaard, S; Jungmann, K; Kruithof, W L; Lantz, M; Perea, A; Riisager, K; Saastamoinen, A; Santra, B; Shidling, P D; Sohani, M; Sørensen, A J; Tengblad, O; Traykov, E; van der Hoek, D J; Van Duppen, P; Versolato, O O; Wilschut, H W

    2012-04-20

    A measurement of the final state distribution of the (8)B β decay, obtained by implanting a (8)B beam in a double-sided silicon strip detector, is reported here. The present spectrum is consistent with a recent independent precise measurement performed by our collaboration at the IGISOL facility, Jyväskylä [O. S. Kirsebom et al., Phys. Rev. C 83, 065802 (2011)]. It shows discrepancies with previously measured spectra, leading to differences in the derived neutrino spectrum. Thanks to a low detection threshold, the neutrino spectrum is for the first time directly extracted from the measured final state distribution, thus avoiding the uncertainties related to the extrapolation of R-matrix fits. Combined with the IGISOL data, this leads to an improvement of the overall errors and the extension of the neutrino spectrum at high energy. The new unperturbed neutrino spectrum represents a benchmark for future measurements of the solar neutrino flux as a function of energy.

  2. Converting Human Proteins into Precision Polymer Therapeutics.

    PubMed

    Boldt, Felix; Liu, Weina; Wu, Yuzhou; Weil, Tanja

    2016-01-01

    Cells as the smallest unit of life rely on precise macromolecules and programmable supramolecular interactions to accomplish the various vital functions. To translate such strategies to precisely control architectures and interactions into the synthetic world represents an exciting endeavor. Polymers with distinct structures, sequences and architectures are still challenging to achieve. However, in particular for biomedical applications, reproducible synthesis, narrow dispersities, tunable functionalities and additionally biocompatibility of the polymeric materials are crucial. Polymers derived from protein precursors provide many advantages of proteins such as precise monomer sequences and contour lengths, biodegradability and multiple functionalities, which can be synergistically combined with the valuable features of synthetic polymers e.g. stability, tunable solubility and molecular weights. The resulting polymeric biohybrid materials offer many applications ranging from drug delivery to biosensing and therapeutic hydrogels. This minireview summarizes the most recent advances in this field.

  3. High precision phase-shifting electron holography

    PubMed

    Yamamoto; Kawajiri; Tanji; Hibino; Hirayama

    2000-01-01

    Today's information-oriented society requires high density and high quality magnetic recording media. The quantitative observation of fine magnetic structures by electron holography is greatly anticipated in the development of such new recording materials. However, the magnetic fields around particles <50 nm have not been observed, because the fields are too weak to observe in the usual way. Here we present a highly precise phase measurement technique: improved phase-shifting electron holography. Using this method, the electric field around a charged polystyrene latex particle (100 nm in diameter) and the magnetic field around iron particles (30 nm in diameter) are observed precisely. A precision of the reconstructed phase image of 2pi/300 rad is achieved in the image of the latex particle.

  4. High-Precision Computation and Mathematical Physics

    SciTech Connect

    Bailey, David H.; Borwein, Jonathan M.

    2008-11-03

    At the present time, IEEE 64-bit floating-point arithmetic is sufficiently accurate for most scientific applications. However, for a rapidly growing body of important scientific computing applications, a higher level of numeric precision is required. Such calculations are facilitated by high-precision software packages that include high-level language translation modules to minimize the conversion effort. This paper presents a survey of recent applications of these techniques and provides some analysis of their numerical requirements. These applications include supernova simulations, climate modeling, planetary orbit calculations, Coulomb n-body atomic systems, scattering amplitudes of quarks, gluons and bosons, nonlinear oscillator theory, Ising theory, quantum field theory and experimental mathematics. We conclude that high-precision arithmetic facilities are now an indispensable component of a modern large-scale scientific computing environment.

  5. Isara 400 ultra-precision CMM

    NASA Astrophysics Data System (ADS)

    Spaan, H. A. M.; Widdershoven, I.

    2011-10-01

    This paper presents the realization of the Isara 400 ultra-precision 3D coordinate measuring machine, which features a measuring volume of 400 × 400 × 100 mm and a traceable measurement uncertainty better than 50 nm. In order to achieve these challenging specifications, specific calibration strategies need to be applied, such as the calibration of the system's mirror table. In addition, a newly developed ultra-precision tactile probe system is described, featuring a probe tip radius of 35 μm results of the 3D sensitivity calibration of this probe are presented. Finally, results are presented measuring a full hemisphere in 3D of a SiN ultra precision master ball, resulting in a repeatability of 7.9 nm rms.

  6. High precision Woelter optic calibration facility

    SciTech Connect

    Morales, R.I.; Remington, B.A.; Schwinn, T. )

    1995-01-01

    We have developed an off-line facility for very precise characterization of the reflectance and spatial resolution of the grazing incidence Woelter type I x-ray optics used at Nova. The primary component of the facility is a new, very versatile, high brightness x-ray source consisting of a focused DC electron beam incident onto a precision manipulated target-pinhole array. The data are recorded with a selection of detectors. For imaging measurements we use direct exposure x-ray film modules or an x-ray charge-coupled device camera. For energy-resolved reflectance measurements, we use lithium drifted silicon detectors and a proportional counter. An [ital in] [ital situ] laser alignment system allows precise location and rapid periodic alignment verification of the x-ray point source, the statically mounted Woelter optic, and the chosen detector.

  7. Precision guided firearms: disruptive small arms technology

    NASA Astrophysics Data System (ADS)

    Boyd, Bret; Lupher, John

    2013-05-01

    Precision Guided Firearms (PGFs) employ target tracking, a Heads-Up Display, and advanced fire control technology to amplify shooting precision at long range by eliminating the most common sources of shooter error, including aim, trigger jerk, and shot setup miscalculation. Regardless of skill level or experience, PGFs significantly increase first shot success probability when compared to traditional technology, even at extreme ranges of 1,200 yards or more. More than just a scope, PGFs are fully integrated systems based on standard caliber bolt action or semi-automatic rifles with a Networked Tracking Scope, Guided Trigger and precision conventional ammunition. Onboard wireless technology allows PGFs to connect with local and wide area networks to deliver voice, video and data to mobile devices and various communication networks. These technologies allow shooters to be more accurate, engage multiple targets at unknown ranges quickly, track and engage moving targets, and communicate via command and control networks.

  8. [On Chinese medicine quality precision in expectation].

    PubMed

    Shi, Ren-bing; Wang, Yong-yan; Lv, Song-tao

    2015-09-01

    According to the correlative analyses on Chinese medicine essence, dosage forms and quality control level, it expounds the precise concept of Chinese medicine, and its quality advantages and characteristics in this paper, furthermore discusses how to achieve the ideal drugs and Chinese medicine quality precision in expectation. Base on the Chinese medicine essence, using the concept of nature medicine and its drug system to construct Chinese medicine effective material basis and its drugs, with the correlative analyses of whole view and reductionism, the problems of uncertainty quality of original natural medicinal resources and preparations may well be solved, and further with the macroscopic to microcosmic construction of drug system, the precision in expectations of Chinese medicine quality and higher production lever may well be achieved.

  9. Superallowed nuclear beta decay: Precision measurements for basic physics

    NASA Astrophysics Data System (ADS)

    Hardy, J. C.

    2012-11-01

    For 60 years, superallowed 0+→0+ nuclear beta decay has been used to probe the weak interaction, currently verifying the conservation of the vector current (CVC) to high precision (±0.01%) and anchoring the most demanding available test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix (±0.06%), a fundamental pillar of the electroweak standard model. Each superallowed transition is characterized by its ft-value, a result obtained from three measured quantities: the total decay energy of the transition, its branching ratio, and the half-life of the parent state. Today's data set is composed of some 150 independent measurements of 13 separate superallowed transitions covering a wide range of parent nuclei from 10C to 74Rb. Excellent consistency among the average results for all 13 transitions - a prediction of CVC - also confirms the validity of the small transition-dependent theoretical corrections that have been applied to account for isospin symmetry breaking. With CVC consistency established, the value of the vector coupling constant, GV, has been extracted from the data and used to determine the top left element of the CKM matrix, Vud. With this result the top-row unitarity test of the CKM matrix yields the value 0.99995(61), a result that sets a tight limit on possible new physics beyond the standard model. To have any impact on these fundamental weak-interaction tests, any measurement must be made with a precision of 0.1% or better - a substantial experimental challenge well beyond the requirements of most nuclear physics measurements. I overview the current state of the field and outline some of the requirements that need to be met by experimentalists if they aim to make measurements with this high level of precision.

  10. Superallowed nuclear beta decay: Precision measurements for basic physics

    SciTech Connect

    Hardy, J. C.

    2012-11-20

    For 60 years, superallowed 0{sup +}{yields}0{sup +} nuclear beta decay has been used to probe the weak interaction, currently verifying the conservation of the vector current (CVC) to high precision ({+-}0.01%) and anchoring the most demanding available test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix ({+-}0.06%), a fundamental pillar of the electroweak standard model. Each superallowed transition is characterized by its ft-value, a result obtained from three measured quantities: the total decay energy of the transition, its branching ratio, and the half-life of the parent state. Today's data set is composed of some 150 independent measurements of 13 separate superallowed transitions covering a wide range of parent nuclei from {sup 10}C to {sup 74}Rb. Excellent consistency among the average results for all 13 transitions - a prediction of CVC - also confirms the validity of the small transition-dependent theoretical corrections that have been applied to account for isospin symmetry breaking. With CVC consistency established, the value of the vector coupling constant, G{sub V}, has been extracted from the data and used to determine the top left element of the CKM matrix, V{sub ud}. With this result the top-row unitarity test of the CKM matrix yields the value 0.99995(61), a result that sets a tight limit on possible new physics beyond the standard model. To have any impact on these fundamental weak-interaction tests, any measurement must be made with a precision of 0.1% or better - a substantial experimental challenge well beyond the requirements of most nuclear physics measurements. I overview the current state of the field and outline some of the requirements that need to be met by experimentalists if they aim to make measurements with this high level of precision.

  11. Precision top-quark mass measurement at CDF.

    PubMed

    Aaltonen, T; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'Orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

    2012-10-12

    We present a precision measurement of the top-quark mass using the full sample of Tevatron √s = 1.96 TeV proton-antiproton collisions collected by the CDF II detector, corresponding to an integrated luminosity of 8.7 fb(-1). Using a sample of tt¯ candidate events decaying into the lepton+jets channel, we obtain distributions of the top-quark masses and the invariant mass of two jets from the W boson decays from data. We then compare these distributions to templates derived from signal and background samples to extract the top-quark mass and the energy scale of the calorimeter jets with in situ calibration. The likelihood fit of the templates from signal and background events to the data yields the single most-precise measurement of the top-quark mass, M(top)=172.85±0.71(stat)±0.85(syst) GeV/c(2).

  12. Precision cosmology, Accuracy cosmology and Statistical cosmology

    NASA Astrophysics Data System (ADS)

    Verde, Licia

    2014-05-01

    The avalanche of data over the past 10-20 years has propelled cosmology into the ``precision era''. The next challenge cosmology has to meet is to enter the era of accuracy. Because of the intrinsic nature of studying the Cosmos and the sheer amount of data available now and coming soon, the only way to meet this challenge is by developing suitable and specific statistical techniques. The road from precision Cosmology to accurate Cosmology goes through statistical Cosmology. I will outline some open challenges and discuss some specific examples.

  13. Precision Editing of Large Animal Genomes

    PubMed Central

    Tan, Wenfang (Spring); Carlson, Daniel F.; Walton, Mark W.; Fahrenkrug, Scott C.; Hackett, Perry B.

    2013-01-01

    Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies. PMID:23084873

  14. Fundamental Limits of Scintillation Detector Timing Precision

    PubMed Central

    Derenzo, Stephen E.; Choong, Woon-Seng; Moses, William W.

    2014-01-01

    In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu2SiO5:Ce and LaBr3:Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10,000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A−1/2 more than any other factor, we tabulated the parameter B, where R = BA−1/2. An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10,000 photoelectrons/ns. A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10,000 photoelectrons/ns. PMID:24874216

  15. Precision Crystal Calorimeters in High Energy Physics

    ScienceCinema

    Ren-Yuan Zhu

    2016-07-12

    Precision crystal calorimeters traditionally play an important role in high energy physics experiments. In the last two decades, it faces a challenge to maintain its precision in a hostile radiation environment. This paper reviews the performance of crystal calorimeters constructed for high energy physics experiments and the progress achieved in understanding crystal’s radiation damage as well as in developing high quality scintillating crystals for particle physics. Potential applications of new generation scintillating crystals of high density and high light yield, such as LSO and LYSO, in particle physics experiments is also discussed.

  16. Precise Applications Of The Global Positioning System

    NASA Technical Reports Server (NTRS)

    Lichten, Stephen M.

    1992-01-01

    Report represents overview of Global Positioning System (GPS). Emphasizes those aspects of theory, history, and status of GPS pertaining to potential utility for highly precise scientific measurements. Current and anticipated applications include measurements of crustal motions in seismically active regions of Earth, measurements of rate of rotation of Earth and orientation of poles, tracking of non-GPS spacecraft in orbit around Earth, surveying, measurements of radio-signal-propagation delays, determinations of coordinates of ground stations, and transfer of precise time signals worldwide.

  17. Precision genetic engineering in large mammals.

    PubMed

    Garrels, Wiebke; Ivics, Zoltan; Kues, Wilfried A

    2012-07-01

    Precision genetic engineering based on stable chromosomal insertion of exogenous DNA in the genomes of large mammals is immensely important for the development of improved biomedical models, pharmaceutical research and an accelerated breeding progress. Precision genetic engineering requires (i) a known locus of genomic integration, (ii) a defined status of foreign DNA, (iii) that transgene expression is unaffected by neighbouring chromosomal sequences, (iv) endogenous genes are not mutated and (v) no unwanted DNA sequences are present. Recently, advanced molecular techniques exploiting exogenous enzymes have opened the possibilities for more sophisticated genetic engineering. Here, we critically review current developments of enzyme-catalysed approaches for targeted transgenesis in large mammals.

  18. High precision detector robot arm system

    DOEpatents

    Shu, Deming; Chu, Yong

    2017-01-31

    A method and high precision robot arm system are provided, for example, for X-ray nanodiffraction with an X-ray nanoprobe. The robot arm system includes duo-vertical-stages and a kinematic linkage system. A two-dimensional (2D) vertical plane ultra-precision robot arm supporting an X-ray detector provides positioning and manipulating of the X-ray detector. A vertical support for the 2D vertical plane robot arm includes spaced apart rails respectively engaging a first bearing structure and a second bearing structure carried by the 2D vertical plane robot arm.

  19. Precision medicine: what's all the fuss about?

    PubMed

    Barker, Richard

    2016-01-01

    Precision medicine is now recognized globally as a major new era in medicine. It is being driven by advances in genomics and other 'omics' but also by the desire on the part of both health systems and governments to offer more targeted and cost-effective care. However, it faces a number of challenges, from the economics of developing more expensive companion diagnostics to the need to educate patients and the public on the advantages for them. New models of both R&D and care delivery are needed to capture the scientific, clinical and economic benefits of precision medicine.

  20. Precision genomic medicine in cystic fibrosis

    PubMed Central

    Chang, Eugene H.; Zabner, Joseph

    2015-01-01

    The successful application of precision genomic medicine requires an understanding of how a person’s genome can influence their disease phenotype and how medical therapies can provide personalized therapy to one’s genotype. In this review, we highlight advances in precision genomic medicine in cystic fibrosis (CF), a classic autosomal recessive genetic disorder. We discuss genotype-phenotype correlations in CF, genetic and environmental modifiers of disease, and pharmacogenetic therapies that target specific genetic mutations thereby addressing the primary defect of cystic fibrosis. PMID:26073768

  1. Research on high-precision laser displacement sensor-based error compensation model

    NASA Astrophysics Data System (ADS)

    Zhang, Zhifeng; Zhai, Yusheng; Su, Zhan; Qiao, Lin; Tang, Yiming; Wang, Xinjie; Su, Yuling; Song, Zhijun

    2015-08-01

    The triangulation measurement is a kind of active vision measurement. The laser triangulation displacement is widely used with advantages of non-contact, high precision, high sensitivity. The measuring error will increase with the nonlinear and noise disturbance when sensors work in large distance. The paper introduces the principle of laser triangulation measurement and analyzes the measuring error and establishes the compensation error. Spot centroid is extracted with digital image processing technology to increase noise-signal ratio. Results of simulation and experiment show the method can meet requirement of large distance and high precision.

  2. NCI and the Precision Medicine Initiative®

    Cancer.gov

    NCI's activities related to precision medicine focuses on new and expanded precision medicine clinical trials; mechanisms to overcome drug resistance to cancer treatments; and developing a shared digital repository of precision medicine trials data.

  3. Precision Medicine In Action | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine In Action Past Issues / Fall 2015 Table of ... Dishman "I am totally motivated to support precision medicine because I am one of the early prototype ...

  4. Supercritical carbon dioxide extraction for PCBS in lake sediments

    SciTech Connect

    Reilly, L.A.; Leddy, D.G.

    1996-10-01

    Supercritical fluid extraction (SFE) with CO{sub 2} of freshwater sediments spiked with selected PCB congeners has been studied at MTU for several years in order to determine the best experimental conditions for analysis. Soxhlet extraction has been used as the method for comparison. The bases for comparison are time requirements, equipment and supply costs, percent recoveries, precision, limit of detection, accuracy and sample size. Results show that SFE yields quantitative recoveries of the PCB cogeners analyzed and is comparable to Soxhlet extraction. Extraction efficiencies are found to be especially dependent on the extraction temperature.

  5. Optical Aperture Synthesis Object's Information Extracting Based on Wavelet Denoising

    NASA Astrophysics Data System (ADS)

    Fan, W. J.; Lu, Y.

    2006-10-01

    Wavelet denoising is studied to improve OAS(optical aperture synthesis) object's Fourier information extracting. Translation invariance wavelet denoising based on Donoho wavelet soft threshold denoising is researched to remove Pseudo-Gibbs in wavelet soft threshold image. OAS object's information extracting based on translation invariance wavelet denoising is studied. The study shows that wavelet threshold denoising can improve the precision and the repetition of object's information extracting from interferogram, and the translation invariance wavelet denoising information extracting is better than soft threshold wavelet denoising information extracting.

  6. Excalibur Precision 155mm Projectiles (Excalibur)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-366 Excalibur Precision 155mm Projectiles (Excalibur) As of FY 2017 President’s Budget...Program Office Estimate RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be

  7. Precision controllability of the YF-17 airplane

    NASA Technical Reports Server (NTRS)

    Sisk, T. R.; Mataeny, N. W.

    1980-01-01

    A flying qualities evaluation conducted on the YF-17 airplane permitted assessment of its precision controllability in the transonic flight regime over the allowable angle of attack range. The precision controllability (tailchase tracking) study was conducted in constant-g and windup turn tracking maneuvers with the command augmentation system (CAS) on, automatic maneuver flaps, and the caged pipper gunsight depressed 70 mils. This study showed that the YF-17 airplane tracks essentially as well at 7 g's to 8 g's as earlier fighters did at 4 g's to 5 g's before they encountered wing rock. The pilots considered the YF-17 airplane one of the best tracking airplanes they had flown. Wing rock at the higher angles of attack degraded tracking precision, and lack of control harmony made precision controllability more difficult. The revised automatic maneuver flap schedule incorporated in the airplane at the time of the tests did not appear to be optimum. The largest tracking errors and greatest pilot workload occurred at high normal load factors at low angles of attack. The pilots reported that the high-g maneuvers caused some tunnel vision and that they found it difficult to think clearly after repeated maneuvers.

  8. High precision, rapid laser hole drilling

    DOEpatents

    Chang, Jim J.; Friedman, Herbert W.; Comaskey, Brian J.

    2007-03-20

    A laser system produces a first laser beam for rapidly removing the bulk of material in an area to form a ragged hole. The laser system produces a second laser beam for accurately cleaning up the ragged hole so that the final hole has dimensions of high precision.

  9. High precision, rapid laser hole drilling

    DOEpatents

    Chang, Jim J.; Friedman, Herbert W.; Comaskey, Brian J.

    2005-03-08

    A laser system produces a first laser beam for rapidly removing the bulk of material in an area to form a ragged hole. The laser system produces a second laser beam for accurately cleaning up the ragged hole so that the final hole has dimensions of high precision.

  10. Precise Electrochemical Drilling of Repeated Deep Holes

    NASA Technical Reports Server (NTRS)

    Kincheloe, J. P.

    1985-01-01

    Tooling enables maintenance of close tolerances. Tooling includes guide that holds electrochemical drilling electrodes in proper relative alinement and guide-positioning fixture clamps directly on reference surfaces of strut. High precision achieved by positioning tooling anew on each strut before drilling: Tolerances of (0.008 mm) maintained in some details.

  11. High precision, rapid laser hole drilling

    DOEpatents

    Chang, Jim J.; Friedman, Herbert W.; Comaskey, Brian J.

    2013-04-02

    A laser system produces a first laser beam for rapidly removing the bulk of material in an area to form a ragged hole. The laser system produces a second laser beam for accurately cleaning up the ragged hole so that the final hole has dimensions of high precision.

  12. High precision measurements in crustal dynamic studies

    NASA Technical Reports Server (NTRS)

    Wyatt, F.; Berger, J.

    1984-01-01

    The development of high-precision instrumentation for monitoring benchmark stability and evaluating coseismic strain and tilt signals is reviewed. Laser strainmeter and tilt observations are presented. Examples of coseismic deformation in several geographic locations are given. Evidence suggests that the Earth undergoes elastic response to abrupt faulting.

  13. Precise Interval Timer for Software Defined Radio

    NASA Technical Reports Server (NTRS)

    Pozhidaev, Aleksey (Inventor)

    2014-01-01

    A precise digital fractional interval timer for software defined radios which vary their waveform on a packet-by-packet basis. The timer allows for variable length in the preamble of the RF packet and allows to adjust boundaries of the TDMA (Time Division Multiple Access) Slots of the receiver of an SDR based on the reception of the RF packet of interest.

  14. High-Precision Photometry with the RCT

    NASA Astrophysics Data System (ADS)

    Everett, M.; Howell, S.; Davis, D.; McGruder, C. H., III; Gelderman, R.; Guinan, E.; Mattox, J. R.; Walter, D. K.

    2003-05-01

    We plan to conduct a high-precision photometric search for transitting extra-solar planets using the refurbished 1.3 m (50 inch) Robotically-Controlled Telescope (RCT) at Kitt Peak. The photometric capabilities and extra-solar planet search strategy for the RCT are discussed. Refurbishment of the RCT has been made possible by NASA grant NAG58762.

  15. Precision Machining Technologies. Occupational Competency Analysis Profile.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Vocational Instructional Materials Lab.

    This Occupational Competency Analysis Profile (OCAP), which is one of a series of OCAPs developed to identify the skills that Ohio employers deem necessary to entering a given occupation/occupational area, lists the occupational, academic, and employability skills required of individuals entering the occupation of precision machinist. The…

  16. High Precision Pressure Measurement with a Funnel

    ERIC Educational Resources Information Center

    Lopez-Arias, T.; Gratton, L. M.; Oss, S.

    2008-01-01

    A simple experimental device for high precision differential pressure measurements is presented. Its working mechanism recalls that of a hydraulic press, where pressure is supplied by insufflating air under a funnel. As an application, we measure air pressure inside a soap bubble. The soap bubble is inflated and connected to a funnel which is…

  17. Sensing technologies for precision specialty crop production

    Technology Transfer Automated Retrieval System (TEKTRAN)

    With the advances in electronic and information technologies, various sensing systems have been developed for specialty crop production around the world. Accurate information concerning the spatial variability within fields is very important for precision farming of specialty crops. However, this va...

  18. Precision Metal Fabrication. Florida Vocational Program Guide.

    ERIC Educational Resources Information Center

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This guide identifies considerations in the organization, operation, and evaluation of secondary and postsecondary vocational education programs. It contains both a vocational program guide and Career Merit Achievement Plan (Career MAP) for precision metal fabrication. The guide contains the following sections: occupational description; program…

  19. Precision agriculture: Data to knowledge decision

    Technology Transfer Automated Retrieval System (TEKTRAN)

    From the development of the first viable variable-rate fertilizer systems in the upper Midwest USA, precision agriculture is now about two decades old. In that time, new technologies have come into play, but the overall goal of using spatial data to create actionable knowledge that can then be used ...

  20. Precision CW laser automatic tracking system investigated

    NASA Technical Reports Server (NTRS)

    Lang, K. T.; Lucy, R. F.; Mcgann, E. J.; Peters, C. J.

    1966-01-01

    Precision laser tracker capable of tracking a low acceleration target to an accuracy of about 20 microradians rms is being constructed and tested. This laser tracking has the advantage of discriminating against other optical sources and the capability of simultaneously measuring range.

  1. Precise Fabrication of Electromagnetic-Levitation Coils

    NASA Technical Reports Server (NTRS)

    Ethridge, E.; Curreri, P.; Theiss, J.; Abbaschian, G.

    1985-01-01

    Winding copper tubing on jig ensures reproducible performance. Sequence of steps insures consistent fabrication of levitation-and-melting coils. New method enables technician to produce eight coils per day, 95 percent of them acceptable. Method employs precise step-by-step procedure on specially designed wrapping and winding jig.

  2. Automated Inspection And Precise Grinding Of Gears

    NASA Technical Reports Server (NTRS)

    Frint, Harold; Glasow, Warren

    1995-01-01

    Method of precise grinding of spiral bevel gears involves automated inspection of gear-tooth surfaces followed by adjustments of machine-tool settings to minimize differences between actual and nominal surfaces. Similar to method described in "Computerized Inspection of Gear-Tooth Surfaces" (LEW-15736). Yields gears of higher quality, with significant reduction in manufacturing and inspection time.

  3. Precision and Recall in Title Keyword Searches.

    ERIC Educational Resources Information Center

    McJunkin, Monica Cahill

    This study examines precision and recall for title and keyword searches performed in the "FirstSearch" WorldCat database when keywords are used with and without adjacency of terms specified. A random sample of 68 titles in economics were searched in the OCLC (Online Computer Library Center) Online Union Catalog in order to obtain their…

  4. 40 CFR 75.41 - Precision criteria.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... collect and analyze data according to the following requirements: (1) Data from the alternative monitoring...) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.41 Precision criteria. (a) Data collection... described in this section. The t-test shall be performed only on sample data at the normal operating...

  5. 40 CFR 75.41 - Precision criteria.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... collect and analyze data according to the following requirements: (1) Data from the alternative monitoring...) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.41 Precision criteria. (a) Data collection... described in this section. The t-test shall be performed only on sample data at the normal operating...

  6. 40 CFR 75.41 - Precision criteria.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... collect and analyze data according to the following requirements: (1) Data from the alternative monitoring...) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.41 Precision criteria. (a) Data collection... described in this section. The t-test shall be performed only on sample data at the normal operating...

  7. Precision Machining Technology. Technical Committee Report.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This Technical Committee Report prepared by industry representatives in Idaho lists the skills currently necessary for an employee in that state to obtain a job in precision machining technology, retain a job once hired, and advance in that occupational field. (Task lists are grouped according to duty areas generally used in industry settings, and…

  8. Fundamental constants: The teamwork of precision

    NASA Astrophysics Data System (ADS)

    Myers, Edmund G.

    2014-02-01

    A new value for the atomic mass of the electron is a link in a chain of measurements that will enable a test of the standard model of particle physics with better than part-per-trillion precision. See Letter p.467

  9. Bullet trajectory reconstruction - Methods, accuracy and precision.

    PubMed

    Mattijssen, Erwin J A T; Kerkhoff, Wim

    2016-05-01

    Based on the spatial relation between a primary and secondary bullet defect or on the shape and dimensions of the primary bullet defect, a bullet's trajectory prior to impact can be estimated for a shooting scene reconstruction. The accuracy and precision of the estimated trajectories will vary depending on variables such as, the applied method of reconstruction, the (true) angle of incidence, the properties of the target material and the properties of the bullet upon impact. This study focused on the accuracy and precision of estimated bullet trajectories when different variants of the probing method, ellipse method, and lead-in method are applied on bullet defects resulting from shots at various angles of incidence on drywall, MDF and sheet metal. The results show that in most situations the best performance (accuracy and precision) is seen when the probing method is applied. Only for the lowest angles of incidence the performance was better when either the ellipse or lead-in method was applied. The data provided in this paper can be used to select the appropriate method(s) for reconstruction and to correct for systematic errors (accuracy) and to provide a value of the precision, by means of a confidence interval of the specific measurement.

  10. Calculation of Geometric Dilution of Precision

    NASA Astrophysics Data System (ADS)

    Zhu, Jijie

    1992-07-01

    In this short communication, a very simple closed-form formula for the calculation of the Geometric Dilution of Precision (GDOP) in Global Positioning System (GPS) navigation and in Global Navigation Satellite System (GLONASS) navigation is presented, which requires less than 40 multiplications.

  11. Precision aligned split V-block

    DOEpatents

    George, Irwin S.

    1984-01-01

    A precision aligned split V-block for holding a workpiece during a milling operation having an expandable frame for allowing various sized workpieces to be accommodated, is easily secured directly to the mill table and having key lugs in one base of the split V-block that assures constant alignment.

  12. Precise Sealing of Fused-Quartz Ampoules

    NASA Technical Reports Server (NTRS)

    Debnan, W. J. J.; Clark, I. O.

    1982-01-01

    New technique rapidly evacuates and seals fused-quartz ampoule with precise clearance over contents without appreciably thinning ampoule walls. Quartz plug is lowered into working section of ampoule after ampoule has been evacuated. Plug is then fused to ampoule walls, forming vacuum seal. New technique maintains wall strength and pumping speed.

  13. Bringing Precision Medicine to Community Oncologists.

    PubMed

    2017-01-01

    Quest Diagnostics has teamed up with Memorial Sloan Kettering Cancer Center and IBM Watson Health to offer IBM Watson Genomics to its network of community cancer centers and hospitals. This new service aims to advance precision medicine by combining genomic tumor sequencing with the power of cognitive computing.

  14. Formulas for Precise Transverse Mercator Projection

    NASA Technical Reports Server (NTRS)

    Wallis, D. E.

    1983-01-01

    Transverse mercator projection, surface of Earth or other spheroid is mapped onto cylinder tangent at meridian of longitude. New method performs mapping by means of mathematical series in which higher order terms correct for deviation from exact sphericity. New method yields precise geodetic maps.

  15. Precision orbit determination of altimetric satellites

    NASA Technical Reports Server (NTRS)

    Shum, C. K.; Ries, John C.; Tapley, Byron D.

    1994-01-01

    The ability to determine accurate global sea level variations is important to both detection and understanding of changes in climate patterns. Sea level variability occurs over a wide spectrum of temporal and spatial scales, and precise global measurements are only recently possible with the advent of spaceborne satellite radar altimetry missions. One of the inherent requirements for accurate determination of absolute sea surface topography is that the altimetric satellite orbits be computed with sub-decimeter accuracy within a well defined terrestrial reference frame. SLR tracking in support of precision orbit determination of altimetric satellites is significant. Recent examples are the use of SLR as the primary tracking systems for TOPEX/Poseidon and for ERS-1 precision orbit determination. The current radial orbit accuracy for TOPEX/Poseidon is estimated to be around 3-4 cm, with geographically correlated orbit errors around 2 cm. The significance of the SLR tracking system is its ability to allow altimetric satellites to obtain absolute sea level measurements and thereby provide a link to other altimetry measurement systems for long-term sea level studies. SLR tracking allows the production of precise orbits which are well centered in an accurate terrestrial reference frame. With proper calibration of the radar altimeter, these precise orbits, along with the altimeter measurements, provide long term absolute sea level measurements. The U.S. Navy's Geosat mission is equipped with only Doppler beacons and lacks laser retroreflectors. However, its orbits, and even the Geosat orbits computed using the available full 40-station Tranet tracking network, yield orbits with significant north-south shifts with respect to the IERS terrestrial reference frame. The resulting Geosat sea surface topography will be tilted accordingly, making interpretation of long-term sea level variability studies difficult.

  16. Precision of Four Acoustic Bone Measurement Devices

    NASA Technical Reports Server (NTRS)

    Miller, Christopher; Rianon, Nahid; Feiveson, Alan; Shackelford, Linda; LeBlanc, Adrian

    2000-01-01

    Though many studies have quantified the precision of various acoustic bone measurement devices, it is difficult to directly compare the results among the studies, because they used disparate subject pools, did not specify the estimation methodology, or did not use consistent definitions for various precision characteristics. In this study, we used a repeated measures design protocol to directly determine the precision characteristics of four acoustic bone measurement devices: the Mechanical Response Tissue Analyzer (MRTA), the UBA-575+, the SoundScan 2000 (S2000), and the Sahara Ultrasound Bone Analyzer. Ten men and ten women were scanned on all four devices by two different operators at five discrete time points: Week 1, Week 2, Week 3, Month 3 and Month 6. The percent coefficient of variation (%CV) and standardized coefficient of variation were computed for the following precision characteristics: interoperator effect, operator-subject interaction, short-term error variance, and long-term drift. The MRTA had high interoperator errors for its ulnar and tibial stiffness measures and a large long-term drift in its tibial stiffness measurement. The UBA-575+ exhibited large short-term error variances and long-term drift for all three of its measurements. The S2000's tibial speed of sound measurement showed a high short-term error variance and a significant operator-subject interaction but very good values (less than 1%) for the other precision characteristics. The Sahara seemed to have the best overall performance, but was hampered by a large %CV for short-term error variance in its broadband ultrasound attenuation measure.

  17. Precision of Four Acoustic Bone Measurement Devices

    NASA Technical Reports Server (NTRS)

    Miller, Christopher; Feiveson, Alan H.; Shackelford, Linda; Rianon, Nahida; LeBlanc, Adrian

    2000-01-01

    Though many studies have quantified the precision of various acoustic bone measurement devices, it is difficult to directly compare the results among the studies, because they used disparate subject pools, did not specify the estimation methodology, or did not use consistent definitions for various precision characteristics. In this study, we used a repeated measures design protocol to directly determine the precision characteristics of four acoustic bone measurement devices: the Mechanical Response Tissue Analyzer (MRTA), the UBA-575+, the SoundScan 2000 (S2000), and the Sahara Ultrasound Done Analyzer. Ten men and ten women were scanned on all four devices by two different operators at five discrete time points: Week 1, Week 2, Week 3, Month 3 and Month 6. The percent coefficient of variation (%CV) and standardized coefficient of variation were computed for the following precision characteristics: interoperator effect, operator-subject interaction, short-term error variance, and long-term drift, The MRTA had high interoperator errors for its ulnar and tibial stiffness measures and a large long-term drift in its tibial stiffness measurement. The UBA-575+ exhibited large short-term error variances and long-term drift for all three of its measurements. The S2000's tibial speed of sound measurement showed a high short-term error variance and a significant operator-subject interaction but very good values ( < 1%) for the other precision characteristics. The Sahara seemed to have the best overall performance, but was hampered by a large %CV for short-term error variance in its broadband ultrasound attenuation measure.

  18. Fiber Scrambling for High Precision Spectrographs

    NASA Astrophysics Data System (ADS)

    Kaplan, Zachary; Spronck, J. F. P.; Fischer, D.

    2011-05-01

    The detection of Earth-like exoplanets with the radial velocity method requires extreme Doppler precision and long-term stability in order to measure tiny reflex velocities in the host star. Recent planet searches have led to the detection of so called "super-Earths” (up to a few Earth masses) that induce radial velocity changes of about 1 m/s. However, the detection of true Earth analogs requires a precision of 10 cm/s. One of the largest factors limiting Doppler precision is variation in the Point Spread Function (PSF) from observation to observation due to changes in the illumination of the slit and spectrograph optics. Thus, this stability has become a focus of current instrumentation work. Fiber optics have been used since the 1980's to couple telescopes to high-precision spectrographs, initially for simpler mechanical design and control. However, fiber optics are also naturally efficient scramblers. Scrambling refers to a fiber's ability to produce an output beam independent of input. Our research is focused on characterizing the scrambling properties of several types of fibers, including circular, square and octagonal fibers. By measuring the intensity distribution after the fiber as a function of input beam position, we can simulate guiding errors that occur at an observatory. Through this, we can determine which fibers produce the most uniform outputs for the severest guiding errors, improving the PSF and allowing sub-m/s precision. However, extensive testing of fibers of supposedly identical core diameter, length and shape from the same manufacturer has revealed the "personality” of individual fibers. Personality describes differing intensity patterns for supposedly duplicate fibers illuminated identically. Here, we present our results on scrambling characterization as a function of fiber type, while studying individual fiber personality.

  19. Application of machine vision based measurement in precise assembly of miniature parts

    NASA Astrophysics Data System (ADS)

    Zhu, Cui; Wang, Xiaodong; Zhang, Xiwen; Wang, Lin; Luo, Yi

    2010-08-01

    In manufacturing of precise miniature devices, automatic assembly is the trend to replace manual work for better quality and higher yield. Precise measurement is a critical issue during assembly process because the parts are often complicated and quite different in size, shapes, surface condition, etc. The position and orientation error must be determined precisely before assembly. In the developed automatic assembly system, microscopic machine vision and precise linear stages were integrated in the measurement system for higher detection resolution and larger measurement range in working space. As to the extract of contour of parts with different surface condition, dynamic illumination control and different combination of feature detection algorithms were applied. The errors brought by non-perpendicularity among precision linear stages were compensated and the movement errors were reduced with effective measurement strategy. The measuring accuracy was validated with a special fabricated precise template. Assembly tests were done with the developed system and results indicate that the required position and orientation accuracy can be met successfully and consequently the assembly task can be fulfilled.

  20. Precise radial velocities in the near infrared

    NASA Astrophysics Data System (ADS)

    Redman, Stephen L.

    Since the first detection of a planet outside our Solar System byWolszczan & Frail (1992), over 500 exoplanets have been found to date2, none of which resemble the Earth. Most of these planets were discovered by measuring the radial velocity (hereafter, RV) of the host star, which wobbles under the gravitational influence of any existing planetary companions. However, this method has yet to achieve the sub-m/s precision necessary to detect an Earth-mass planet in the Habitable Zone (the region around a star that can support liquid water; hereafter, HZ) (Kasting et al. 1993) around a Solar-type star. Even though Kepler (Borucki et al. 2010) has announced several Earth-sized HZ candidates, these targets will be exceptionally difficult to confirm with current astrophysical spectrographs (Borucki et al. 2011). The fastest way to discover and confirm potentiallyhabitable Earth-mass planets is to observe stars with lower masses - in particular, late M dwarfs. While M dwarfs are readily abundant, comprising some 70% of the local stellar population, their low optical luminosity presents a formidable challenge to current optical RV instruments. By observing in the near-infrared (hereafter, NIR), where the flux from M dwarfs peaks, we can potentially reach low RV precisions with significantly less telescope time than would be required by a comparable optical instrument. However, NIR precision RV measurements are a relatively new idea and replete with challenges: IR arrays, unlike CCDs, are sensitive to the thermal background; modal noise is a bigger issue in the NIR than in the optical; and the NIR currently lacks the calibration sources like the very successful thorium-argon (hereafter, ThAr) hollow-cathode lamp and Iodine gas cell of the optical. The PSU Pathfinder (hereafter, Pathfinder) was designed to explore these technical issues with the intention of mitigating these problems for future NIR high-resolution spectrographs, such as the Habitable-Zone Planet Finder (HZPF

  1. Precise measurement of instantaneous volume of eccrine sweat gland in mental sweating by optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

    2015-03-01

    We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). We propose a method for extraction of the target eccrine sweat gland by use of the connected component extraction process and the adaptive threshold method, where the en-face OCT images are constructed by the SS-OCT. Furthermore, we demonstrate precise measurement of instantaneous volume of the sweat gland in response to the external stimulus. The dynamic change of instantaneous volume of eccrine sweat gland in mental sweating is performed by this method during the period of 300 sec with the frame intervals of 3.23 sec.

  2. A Radiometer for Precision Coherent Radiation Measurements

    PubMed Central

    Thomas, Douglas B.; Zalewski, Edward F.

    1992-01-01

    A radiometer has been designed for precision colierent radiation measurements and tested for long-term repeatability at wavelengths of 488 and 633 nm. The radiometer consists of a pn silicon photodiode maintained in a nitrogen atmosphere with a quartz window designed to eliminate interference problems. Ratio measurements between the radiometer and an absolute type detector were made over a period of 215 d. At 0.5 mW, the standard deviations were 0.008% and 0.009% at 488 and 633 nm, respectively. The maximum deviations from the mean were 0.016% and 0.015% at the respective wavelengths. Measurements were also made on the radiometer with respect to angular and spatial uniformity and linearity. The high precision, simplicity, and portability of the radiometer suggest it for use as a transfer standard for radiometric measurements. PMID:28053435

  3. Precisely Timing Dissipative Quantum Information Processing

    NASA Astrophysics Data System (ADS)

    Kastoryano, M. J.; Wolf, M. M.; Eisert, J.

    2013-03-01

    Dissipative engineering constitutes a framework within which quantum information processing protocols are powered by system-environment interaction rather than by unitary dynamics alone. This framework embraces noise as a resource and, consequently, offers a number of advantages compared to one based on unitary dynamics alone, e.g., that the protocols are typically independent of the initial state of the system. However, the time independent nature of this scheme makes it difficult to imagine precisely timed sequential operations, conditional measurements, or error correction. In this work, we provide a path around these challenges, by introducing basic dissipative gadgets which allow us to precisely initiate, trigger, and time dissipative operations while keeping the system Liouvillian time independent. These gadgets open up novel perspectives for thinking of timed dissipative quantum information processing. As an example, we sketch how measurement-based computation can be simulated in the dissipative setting.

  4. Precisely timing dissipative quantum information processing.

    PubMed

    Kastoryano, M J; Wolf, M M; Eisert, J

    2013-03-15

    Dissipative engineering constitutes a framework within which quantum information processing protocols are powered by system-environment interaction rather than by unitary dynamics alone. This framework embraces noise as a resource and, consequently, offers a number of advantages compared to one based on unitary dynamics alone, e.g., that the protocols are typically independent of the initial state of the system. However, the time independent nature of this scheme makes it difficult to imagine precisely timed sequential operations, conditional measurements, or error correction. In this work, we provide a path around these challenges, by introducing basic dissipative gadgets which allow us to precisely initiate, trigger, and time dissipative operations while keeping the system Liouvillian time independent. These gadgets open up novel perspectives for thinking of timed dissipative quantum information processing. As an example, we sketch how measurement-based computation can be simulated in the dissipative setting.

  5. High precision tracking method for solar telescopes

    NASA Astrophysics Data System (ADS)

    Guo, Jingjing; Yang, Yunfei; Feng, Song; Ji, Kanfan; Lin, Jiaben; Zeng, Zhen; Wang, Bingxiang

    2016-07-01

    A high-precision real-time tracking method for solar telescopes was introduced in this paper based on the barycenter of full-disk solar images algorithm. To make sure the calculation was accurate and reliable, a series of strictly logic limits were set, such as setting gray threshold, judging the displacement of the barycenter and measuring the deviation from a perfect disk. A closed-loop control system was designed in the method. We located the barycenter of the full-disk images which recorded by large array CCD image sensor in real time and eliminate noise caused by bad weather, such as clouds and fog. The displacement of the barycenter was analyzed and transferred into control signal drove the motor to adjust the axis of telescope. An Ethernet interface was also provided for remote control. In the observation, the precision of this new method was better than 1″/30 minutes.

  6. Mobile Robotic Teams Applied to Precision Agriculture

    SciTech Connect

    Anderson, Matthew Oley; Kinoshita, Robert Arthur; Mckay, Mark D; Willis, Walter David; Gunderson, R.W.; Flann, N.S.

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University’s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in realtime. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  7. Mobile Robotic Teams Applied to Precision Agriculture

    SciTech Connect

    M.D. McKay; M.O. Anderson; N.S. Flann; R.A. Kinoshita; R.W. Gunderson; W.D. Willis

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University�s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in real-time. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  8. A primer on precision medicine informatics.

    PubMed

    Sboner, Andrea; Elemento, Olivier

    2016-01-01

    In this review, we describe key components of a computational infrastructure for a precision medicine program that is based on clinical-grade genomic sequencing. Specific aspects covered in this review include software components and hardware infrastructure, reporting, integration into Electronic Health Records for routine clinical use and regulatory aspects. We emphasize informatics components related to reproducibility and reliability in genomic testing, regulatory compliance, traceability and documentation of processes, integration into clinical workflows, privacy requirements, prioritization and interpretation of results to report based on clinical needs, rapidly evolving knowledge base of genomic alterations and clinical treatments and return of results in a timely and predictable fashion. We also seek to differentiate between the use of precision medicine in germline and cancer.

  9. Precision medicine--delivering the goods?

    PubMed

    Peer, Dan

    2014-09-28

    Personalized (or precision) medicine aims to individualize therapeutic interventions, based on OMICS data such as genomics, proteomics, metabolomics etc', profiling together with histopathological insights to the type, stage, and the grade of the disease, as well as on the potential response of a particular patient to a particular treatment regimen. With next generation sequencing technologies, it is now possible to identify all germline variants of an individual in an affordable cost and thus paving the way for clinicians to provide healthcare from an individual perspective. In this special issue of Cancer Letters termed "Trends in Personalized Cancer Research" we bring together physicians and scientists summarizing the state-of-the-art in precision medicine from hematological malignancies and solid tumors with the current gold standard diagnostic and therapy to basic and translational research utilizing nanotechnology and RNA interference strategies for future personalized theranostics in oncology.

  10. Precision medicine for acute myeloid leukemia.

    PubMed

    Lai, Catherine; Karp, Judith E; Hourigan, Christopher S

    2016-01-01

    The goal of precision medicine is to personalize therapy based on individual patient variation, to correctly select the right treatment, for the right patient, at the right time. Acute myeloid leukemia (AML) is a heterogeneous collection of myeloid malignancies with diverse genetic etiology and the potential for intra-patient clonal evolution over time. We discuss here how the precision medicine paradigm might be applied to the care of AML patients by focusing on the potential roles of targeting therapy by patient-specific somatic mutations and aberrant pathways, ex-vivo drug sensitivity and resistance testing, high sensitivity measurements of residual disease burden and biology along with potential clinical trial and regulatory constraints.

  11. Precise adaptation in chemotaxis through ``assistance neighborhoods"

    NASA Astrophysics Data System (ADS)

    Endres, Robert; Wingreen, Ned

    2006-03-01

    The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals over a broad range of ambient concentrations. Key to this sensitivity is an adaptation system that relies on methylation and demethylation/deamidation of specific modification sites of the chemoreceptors by the enzymes CheR and CheB, respectively. These enzymes can access 5-7 receptors once tethered to a particular receptor. Based on these ``assistance neighborhoods'', we present a model for precise adaptation of mixed clusters of two-state chemoreceptors. In agreement with experiment the response of adapted cells to addition/removal of attractant scales with the free-energy change at fixed ligand affinity. Our model further predicts two possible limits of precise adaptation: either the response to further addition of attractant stops through saturation of the receptors, or receptors fully methylate before they saturate and therefore stop adapting.

  12. Precise Masses of Young Stars in Taurus

    NASA Astrophysics Data System (ADS)

    Schaefer, Gail

    2011-08-01

    We propose to continue mapping the orbits of young stars in the Taurus star forming region using adaptive optics imaging at Keck. We are near our goal of measuring the masses of the binary components in Elias 12N and NTT 045251+3016 to better than 5-10%. This level of precision is important to validate and distinguish among theoretical calculations of pre-main-sequence evolution. We have reached this point thanks to consistent assignments of time. In 2011B, we expect to obtain high precision measurements of these binaries at orbital phases that were not well-sampled previously, leading to improvements in the dynamical masses. The proposed observations will also enable us to map the orbits for recently resolved systems at small separations (HBC 351, HBC 360/361) and lay critical groundwork for the longer period binaries in our sample.

  13. Precise time dissemination via portable atomic clocks

    NASA Technical Reports Server (NTRS)

    Putkovich, K.

    1982-01-01

    The most precise operational method of time dissemination over long distances presently available to the Precise Time and Time Interval (PTTI) community of users is by means of portable atomic clocks. The Global Positioning System (GPS), the latest system showing promise of replacing portable clocks for global PTTI dissemination, was evaluated. Although GPS has the technical capability of providing superior world-wide dissemination, the question of present cost and future accessibility may require a continued reliance on portable clocks for a number of years. For these reasons a study of portable clock operations as they are carried out today was made. The portable clock system that was utilized by the U.S. Naval Observatory (NAVOBSY) in the global synchronization of clocks over the past 17 years is described and the concepts on which it is based are explained. Some of its capabilities and limitations are also discussed.

  14. Precision Medicine for Acute Myeloid Leukemia

    PubMed Central

    Lai, Catherine; Karp, Judith E.; Hourigan, Christopher S.

    2016-01-01

    The goal of precision medicine is to personalize therapy based on individual patient variation, to correctly select the right treatment, for the right patient, at the right time. Acute myeloid leukemia (AML) is a heterogeneous collection of myeloid malignancies with diverse genetic etiology and the potential for intra-patient clonal evolution over time. We discuss here how the precision medicine paradigm might be applied to the care of AML patients by focusing on the potential roles of targeting therapy by patient-specific somatic mutations and aberrant pathways, ex-vivo drug sensitivity and resistance testing, high sensitivity measurements of residual disease burden and biology along with potential clinical trial and regulatory constraints. PMID:26514194

  15. Improved precision-guaranteed quantum tomography

    NASA Astrophysics Data System (ADS)

    Sugiyama, Takanori

    Quantum tomography is one of the standard tool in current quantum information experiments for verifying that a state/process/measurement prepared in the lab is close to an ideal target. Precision-guaranteed quantum tomography (Sugiyama, Turner, Murao, PRL 111, 160406 2013) gives rigorous error bars on a result estimated from arbitrary finite data sets from any given informationally complete tomography experiments. The rigorous error bars were derived with a real-valued concentration inequality called Hoeffding's inequality. In this talk, with a vector-valued concentration inequality, we provide an improved version of the error bars of precision-guaranteed quantum tomography. We examine the new error bars for specific cases of multi-qubit systems and numerically show that the degree of improvement becomes large as the dimension of the system increases. Supported by JSPS Research Fellowships for Young Scientists H27-276 and JSPS Postdoctoral Fellowships for Research Abroad H25-32.

  16. Geostatistics, remote sensing and precision farming.

    PubMed

    Mulla, D J

    1997-01-01

    Precision farming is possible today because of advances in farming technology, procedures for mapping and interpolating spatial patterns, and geographic information systems for overlaying and interpreting several soil, landscape and crop attributes. The key component of precision farming is the map showing spatial patterns in field characteristics. Obtaining information for this map is often achieved by soil sampling. This approach, however, can be cost-prohibitive for grain crops. Soil sampling strategies can be simplified by use of auxiliary data provided by satellite or aerial photo imagery. This paper describes geostatistical methods for estimating spatial patterns in soil organic matter, soil test phosphorus and wheat grain yield from a combination of Thematic Mapper imaging and soil sampling.

  17. Advanced composite materials for precision segmented reflectors

    NASA Technical Reports Server (NTRS)

    Stein, Bland A.; Bowles, David E.

    1988-01-01

    The objective in the NASA Precision Segmented Reflector (PSR) project is to develop new composite material concepts for highly stable and durable reflectors with precision surfaces. The project focuses on alternate material concepts such as the development of new low coefficient of thermal expansion resins as matrices for graphite fiber reinforced composites, quartz fiber reinforced epoxies, and graphite reinforced glass. Low residual stress fabrication methods will be developed. When coupon specimens of these new material concepts have demonstrated the required surface accuracies and resistance to thermal distortion and microcracking, reflector panels will be fabricated and tested in simulated space environments. An important part of the program is the analytical modeling of environmental stability of these new composite materials concepts through constitutive equation development, modeling of microdamage in the composite matrix, and prediction of long term stability (including viscoelasticity). These analyses include both closed form and finite element solutions at the micro and macro levels.

  18. Portable high precision pressure transducer system

    DOEpatents

    Piper, T.C.; Morgan, J.P.; Marchant, N.J.; Bolton, S.M.

    1994-04-26

    A high precision pressure transducer system is described for checking the reliability of a second pressure transducer system used to monitor the level of a fluid confined in a holding tank. Since the response of the pressure transducer is temperature sensitive, it is continually housed in an battery powered oven which is configured to provide a temperature stable environment at specified temperature for an extended period of time. Further, a high precision temperature stabilized oscillator and counter are coupled to a single board computer to accurately determine the pressure transducer oscillation frequency and convert it to an applied pressure. All of the components are powered by the batteries which during periods of availability of line power are charged by an on board battery charger. The pressure readings outputs are transmitted to a line printer and a vacuum fluorescent display. 2 figures.

  19. Portable high precision pressure transducer system

    DOEpatents

    Piper, Thomas C.; Morgan, John P.; Marchant, Norman J.; Bolton, Steven M.

    1994-01-01

    A high precision pressure transducer system for checking the reliability of a second pressure transducer system used to monitor the level of a fluid confined in a holding tank. Since the response of the pressure transducer is temperature sensitive, it is continually housed in an battery powered oven which is configured to provide a temperature stable environment at specified temperature for an extended period of time. Further, a high precision temperature stabilized oscillator and counter are coupled to a single board computer to accurately determine the pressure transducer oscillation frequency and convert it to an applied pressure. All of the components are powered by the batteries which during periods of availability of line power are charged by an on board battery charger. The pressure readings outputs are transmitted to a line printer and a vacuum florescent display.

  20. Imaging Instrumentation and Techniques for Precision Radiotherapy

    NASA Astrophysics Data System (ADS)

    Parodi, Katia; Parodi, Katia; Thieke, Christian; Thieke, Christian

    Over the last decade, several technological advances have considerably improved the achievable precision of dose delivery in radiation therapy. Clinical exploitation of the superior tumor-dose conformality offered by modern radiotherapy techniques like intensity-modulated radiotherapy and ion beam therapy requires morphological and functional assessment of the tumor during the entire therapy chain from treatment planning to beam application and treatment response evaluation. This chapter will address the main rationale and role of imaging in state-of-the-art external beam radiotherapy. Moreover, it will present the status of novel imaging instrumentation and techniques being nowadays introduced in clinical use or still under development for image guidance and, ultimately, dose guidance of precision radiotherapy.