76 FR 70046 - Airworthiness Directives; Eurocopter France Model AS350B, B1, B2, B3, BA, C, D, and D1; and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-10

... Airworthiness Directives; Eurocopter France Model AS350B, B1, B2, B3, BA, C, D, and D1; and AS355E, F, F1, F2, N... France (Eurocopter) Model AS350B, B1, B2, B3, BA, C, D, and D1 helicopters; and Model AS355E, F, F1, F2... (AD 2003- 22-06), for Eurocopter Model AS350B, B1, B2, B3, BA, C, D, and D1; and Model AS355E, F, F1...

47 CFR 80.205 - Bandwidths.

Code of Federal Regulations, 2010 CFR

2010-10-01

... frequency deviation for F3E or G3E emission is as follows: (1) 5 kHz in the 72.0-73.0 MHz, 75.4-76.0 MHz and... 12 16K0A2D 20.0 A3E 6K00A3E 8.0 A3N 2 2K66A3N 2.8 A3X 3 3K20A3X 25.0 F1B 4 280HF1B 0.3 F1B 5 300HF1B 0.5 F1B 6 16KOF1B 20.0 F1C 2K80F1C 3.0 F1D 12 16K0F1D 20.0 F2B 6 16KOF2B 20.0 F2C 7 16KOF2C 20.0 F2D...

The Ratio of Estimated Average Glucose to Fasting Plasma Glucose Level Is Superior to Glycated Albumin, Hemoglobin A1c, Fructosamine, and GA/A1c Ratio for Assessing β-Cell Function in Childhood Diabetes

PubMed Central

Lee, Ji Eun; Lee, Ji Woo; Fujii, Tatsuyoshi; Fujii, Noriyoshi; Choi, Jong Weon

2014-01-01

Objective. This study investigated the use of the estimated average glucose to fasting plasma glucose ratio (eAG/fPG ratio) to screen for β-cell function in pediatric diabetes. Methods. Glycated hemoglobin (HbA1c), glycated albumin (GA), fructosamine, insulin, and C-peptide levels were measured. The ratio of GA to HbA1c (GA/A1c ratio) was calculated, and the homeostasis model assessment of β-cell function (HOMA-β) was determined. Results. Median values of C-peptide, insulin, and HOMA-β levels were significantly higher in patients with an increased eAG/fPG ratio than in those with a decreased eAG/fPG ratio. C-peptide and HOMA-β levels were more closely correlated with the eAG/fPG ratio than with GA, HbA1c, the GA/A1c ratio, and fructosamine. In contrast, body mass index was significantly associated with GA, GA/A1c ratio, and fructosamine, but not with the eAG/fPG ratio and HbA1c levels. To test the diagnostic accuracies of the eAG/fPG ratio for identifying HOMA-β > 30.0% in patients with type 2 diabetes, the area under the ROC curve of the eAG/fPG ratio was significantly larger than that of the GA/A1c ratio [0.877 (95% CI, 0.780–0.942) versus 0.775 (95% CI, 0.664–0.865), P = 0.039]. Conclusions. A measurement of the eAG/fPG ratio may provide helpful information for assessing β-cell function in pediatric patients with diabetes. PMID:25013775

Magainin 2a - Induced Permeabilization of Phospholipid Vesicles

DTIC Science & Technology

1991-01-02

flJ ə) fl) C rH -H 0) E M D e t e 1 0 0 % • 43 • fl) J3 0 C3...fl) +) ft-H to U4 EH RJ OP 43 o 4J H -H IS *M 0 0 fl) c to 0 • H O 4J O -H in 73 TJ h RJ 0 MH >t 43 fl) to TJ flj fl) fl) C...r H - H F r e t e r m O fl) VD TJ tp to G rt •rH r% f o l l o w : f 6 C F 1 O 43 0) to T J flJ fl) fl) C rH •H fl) E Ul

Molecular Biology of STLV-III and HTLV-IV

DTIC Science & Technology

1990-08-22

8217 AT( ACCA CTCAT.(3CA 5 Ci.T G,- .... ; . , P P, ( L D O S H s v H I -U" G r L "S " V " " , 3 E E 7 ’ T - ’ ’ ’ TJ - " t f? I f T G A- C-. C .T ’ CA8C P...R S N T V K N S D’ . Y S T m 2: G ! Y ’) V V G v I L L R 7 V T Y I’ ,9 M 3: i E F M C f7 E e I V C? iT C? e S . (N*’ 1 . Flist 5At(3CTAGC’’TAATGrAG

A Hybrid Approach for Fault Detection in Autonomous Physical Agents

DTIC Science & Technology

2014-05-01

r l e c c f t d f a d c r r r t m e o i m s f U m d o s a u v c o t c r c t a c u n b S...escription e a set of attrib d, heading, pi et of values for alue assigned to t i s 1 l m a o p a r tr l c tr w o t n data H & ow detection mode roach is...dete Note that any ch can be used t e an autonomou e SFDD

Department of Defense Youth Poll Wave 10 - December 2005. Overview Report

DTIC Science & Technology

2006-07-01

Fishbein , M . & Ajzen , I . (1975). Belief, attitude, intention and behavior: An introduction to theory...a n d E x p e c t e d O u t c o m e s A s s o c ia t e d w it h M il i t a r y S e r v ic e I n f lu e n c e r s M i l i t a r y B e l ie...f s a n d Y o u t h M o t iv a t io n t o C o m p ly Y o u t h A t t i t u d e s N o r m s Y o u t h C o n f id e n c e in S u c c e s

The Effect of Strakes on Vortical Flows Applied to Aircraft.

DTIC Science & Technology

1984-03-31

ORDONEZ 31 NRR 84 UNCLASSIFIED VK! PR-1983 22 EOARD-TR-94-14 RFOSR-83-8i26 F /G 2014 ML _mhhhhhmhhmml Iommomom Ilffffffffffff Big I. ’z.’ MICROCOPY...dS - f dS (1) ’A This equation does not take into account the effect of pressure gradients between the control surfaces. The total head formula is...000 E+0 C’_. 3C’’)C .r.,E+ 02 0, 15C’C’C ’E+ (2 - . 129704E-12 -C’. 120900E- 12 0. 250’)’OE+02 1’ 5 f ’ 0CCE+ 02 -0 176122E+02 -0. 194824E+00 0. 2rQCQ

Excess electron is trapped in a large single molecular cage C60F60.

PubMed

Wang, Yin-Feng; Li, Zhi-Ru; Wu, Di; Sun, Chia-Chung; Gu, Feng-Long

2010-01-15

A new kind of solvated electron systems, sphere-shaped e(-)@C60F60 (I(h)) and capsule-shaped e(-)@C60F60 (D6h), in contrast to the endohedral complex M@C60, is represented at the B3LYP/6-31G(d) + dBF (diffusive basis functions) density functional theory. It is proven, by examining the singly occupied molecular orbital (SOMO) and the spin density map of e(-)@C60F60, that the excess electron is indeed encapsulated inside the C60F60 cage. The shape of the electron cloud in SOMO matches with the shape of C60F60 cage. These cage-like single molecular solvated electrons have considerably large vertical electron detachment energies VDE of 4.95 (I(h)) and 4.67 eV (D6h) at B3LYP/6-31+G(3df) + dBF level compared to the VDE of 3.2 eV for an electron in bulk water (Coe et al., Int Rev Phys Chem 2001, 20, 33) and that of 3.66 eV for e(-)@C20F20 (Irikura, J Phys Chem A 2008, 112, 983), which shows their higher stability. The VDE of the sphere-shaped e(-)@C60F60 (I(h)) is greater than that of the capsule-shaped e(-)@C60F60 (D6h), indicating that the excess electron prefers to reside in the cage with the higher symmetry to form the more stable solvated electron. It is also noticed that the cage size [7.994 (I(h)), 5.714 and 9.978 A (D6h) in diameter] is much larger than that (2.826 A) of (H2O)20- dodecahedral cluster (Khan, Chem Phys Lett 2005, 401, 85). Copyright 2009 Wiley Periodicals, Inc.

NAVAIR - U.S. Navy Naval Air Systems Command - Navy and Marine Corps

Science.gov Websites

FOIA Aircraft & Weapons Fixed Wing AV-8B C-2 C-9 C-12 C-20 C-26 C-37 / C-38 C-40 C-130 E-2 E-6B EA -6B EA-18G F-5 F-16 F-35 F/A-18 P-3 P-8 Trainers UC-35 Specialized and Proven Aircraft Rotorcraft H-1 H-53 H-60 V-22 Presidential Helicopter Trainers Specialized and Proven Aircraft Weapons AARGM

Correlating Temporal Rules to Time-Series Data With Rule-Based Intuition

DTIC Science & Technology

2010-03-01

t i m e o b j e c t and r e t u r n s True ( i n r u l e ) or F a l s e ( n o t i n r u l e ) . Des ign : r u l e l i s t − an a r r a y t h...e . d a t e o b j e c t s . ””” def i n i t ( s e l f , name , days , i g n o r e y e a r =True ) : s e l f . name = name s e l f . days = days 49 s...a l . tm wday == 6 r u l e l i s t . append ( Sunday ( ) ) c l a s s J a n u a r y ( TimeRule ) : ””” I s True i f i t i s January

Exercise Dread Night: Using Allied Medical Publication-8(C) to Estimate Chemical, Biological, Radiological, and Nuclear (CBRN) Casualties

DTIC Science & Technology

2010-08-01

I N S T I T U T E F O R D E F E N S E A N A LY S E S IDA Document D-4130 August 2010 Exercise “Dread Night”: Using Allied Medical Publication-8(C...scientific and technical expertise, and conduct related research on other national challenges. I N S T I T U T E F O R D E F E N S E A N A LY S E...insult can be simply postulated, but it can also be calculated using the methodology described in AMedP-8(C). The latter approach was the one taken in

Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation

PubMed Central

Yang, Shu; Wu, Bo; Sun, Haimei; Ji, Fengqing; Sun, Tingyi; Zhao, Yan; Zhou, Deshan

2015-01-01

Tumour suppressor miR-34c deficiency resulted from hyper-methylation in its promoter is believed to be one of the main causes of colorectal cancer (CRC). Till date, miR-34c has been validated as a direct target of p53; but previous evidence suggested other transcription factor(s) must be involved in miR-34c transcription. In the present study, we in the first place identified a core promoter region (−1118 to −883 bp) of pre-miR-34c which was embedded within a hyper-methylated CpG island. Secondly, E2F1 promoted miR-34c transcription by physical interaction with the miR-34c promoter at site −897 to −889 bp. The transcriptional activating effect of E2F1 on miR-34c was in a p53 independent manner but profoundly promoted in the presence of p53 with exposure to 5-aza-2′-deoxycytidine (DAC). Thirdly, stem cell factor (SCF), a miR-34c target, was specifically reduced upon an introduction of E2F1 which lead to suppression of CRC cell proliferation. The E2F1-suppressed cell proliferation was partially abrogated by additional miR-34c inhibitor, indicating that the anti-proliferation effect of E2F1 was probably through activating miR-34c-SCF axis. Finally, SCF/KIT signalling increased E2F1 production by reducing its proteosomal degradation dependent on PI3K/Akt-GSK3β pathway. In conclusion, our results suggested the existence of E2F1-miR-34c-SCF negative feedback loop which was interrupted by the hyper-methylation of miR-34c promoter in CRC cells and increased cell proliferation. PMID:26704889

A simple method relating specific rate constants k(E,J) and Thermally averaged rate constants k(infinity)(T) of unimolecular bond fission and the reverse barrierless association reactions.

PubMed

Troe, J; Ushakov, V G

2006-06-01

This work describes a simple method linking specific rate constants k(E,J) of bond fission reactions AB --> A + B with thermally averaged capture rate constants k(cap)(T) of the reverse barrierless combination reactions A + B --> AB (or the corresponding high-pressure dissociation or recombination rate constants k(infinity)(T)). Practical applications are given for ionic and neutral reaction systems. The method, in the first stage, requires a phase-space theoretical treatment with the most realistic minimum energy path potential available, either from reduced dimensionality ab initio or from model calculations of the potential, providing the centrifugal barriers E(0)(J). The effects of the anisotropy of the potential afterward are expressed in terms of specific and thermal rigidity factors f(rigid)(E,J) and f(rigid)(T), respectively. Simple relationships provide a link between f(rigid)(E,J) and f(rigid)(T) where J is an average value of J related to J(max)(E), i.e., the maximum J value compatible with E > or = E0(J), and f(rigid)(E,J) applies to the transitional modes. Methods for constructing f(rigid)(E,J) from f(rigid)(E,J) are also described. The derived relationships are adaptable and can be used on that level of information which is available either from more detailed theoretical calculations or from limited experimental information on specific or thermally averaged rate constants. The examples used for illustration are the systems C6H6+ <==> C6H5+ + H, C8H10+ --> C7H7+ + CH3, n-C9H12+ <==> C7H7+ + C2H5, n-C10H14+ <==> C7H7+ + C3H7, HO2 <==> H + O2, HO2 <==> HO + O, and H2O2 <==> 2HO.

Correlation between the conformational states of F1-ATPase as determined from its crystal structure and single-molecule rotation

PubMed Central

Okuno, Daichi; Fujisawa, Ryo; Iino, Ryota; Hirono-Hara, Yoko; Imamura, Hiromi; Noji, Hiroyuki

2008-01-01

F1-ATPase is a rotary molecular motor driven by ATP hydrolysis that rotates the γ-subunit against the α3β3 ring. The crystal structures of F1, which provide the structural basis for the catalysis mechanism, have shown essentially 1 stable conformational state. In contrast, single-molecule studies have revealed that F1 has 2 stable conformational states: ATP-binding dwell state and catalytic dwell state. Although structural and single-molecule studies are crucial for the understanding of the molecular mechanism of F1, it remains unclear as to which catalytic state the crystal structure represents. To address this issue, we introduced cysteine residues at βE391 and γR84 of F1 from thermophilic Bacillus PS3. In the crystal structures of the mitochondrial F1, the corresponding residues in the ADP-bound β (βDP) and γ were in direct contact. The βE190D mutation was additionally introduced into the β to slow ATP hydrolysis. By incorporating a single copy of the mutant β-subunit, the chimera F1, α3β2β(E190D/E391C)γ(R84C), was prepared. In single-molecule rotation assay, chimera F1 showed a catalytic dwell pause in every turn because of the slowed ATP hydrolysis of β(E190D/E391C). When the mutant β and γ were cross-linked through a disulfide bond between βE391C and γR84C, F1 paused the rotation at the catalytic dwell angle of β(E190D/E391C), indicating that the crystal structure represents the catalytic dwell state and that βDP is the catalytically active form. The former point was again confirmed in experiments where F1 rotation was inhibited by adenosine-5′-(β,γ-imino)-triphosphate and/or azide, the most commonly used inhibitors for the crystallization of F1. PMID:19075235

Brief Report: Efficacy and Safety of Switching to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide (E/C/F/TAF) in Virologically Suppressed Women.

PubMed

Hodder, Sally; Squires, Kathleen; Kityo, Cissy; Hagins, Debbie; Avihingsanon, Anchalee; Kido, Anna; Jiang, Shuping; Kulkarni, Rima; Cheng, Andrew; Cao, Huyen

2018-06-01

The integrase inhibitor regimen [elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (TDF)] demonstrated superior efficacy when compared with a protease inhibitor regimen [ritonavir-boosted atazanavir (ATV + RTV) and FTC/TDF] in 575 treatment-naive women at week 48. We investigated the efficacy, safety, and tolerability of switching to a TAF-based, single-tablet regimen containing elvitegravir, cobicistat, FTC, and tenofovir alafenamide (E/C/F/TAF) versus remaining on ATV + RTV plus FTC/TDF. After completing the initial randomized, blinded phase, virologically suppressed (HIV-1 RNA <50 copies/mL) women on ATV + RTV plus FTC/TDF were rerandomized (3:1) to receive open-label E/C/F/TAF versus remaining on their current regimen. The primary end point was proportion of participants with plasma HIV-1 RNA <50 copies per milliliter at week 48 (U.S. FDA snapshot algorithm), with a prespecified noninferiority margin of 12%. Safety [adverse events (AEs)] and tolerability were also assessed. Of 575 women originally randomized and treated in the blinded phase, 159 were rerandomized to switch to E/C/F/TAF and 53 to remain on ATV + RTV plus FTC/TDF. At week 48, virologic suppression was maintained in 150 (94%) of women on E/C/F/TAF and 46 (87%) on ATV + RTV plus FTC/TDF [difference 7.5% (95% confidence interval -1.2% to 19.4%)], demonstrating noninferiority of E/C/F/TAF to ATV + RTV and FTC/TDF. Incidence of AEs was similar between groups; study drug-related AEs were more common with E/C/F/TAF (11% versus 4%). Switching to E/C/F/TAF was noninferior to continuing ATV + RTV plus FTC/TDF in maintaining virologic suppression and was well tolerated at 48 weeks.

Three - Dimensional Image Generation from an Aerial Photograph.

DTIC Science & Technology

1987-09-01

through 183 of the terrain model. To verify that this set of elevation points would appear like the desired reference image, a line drawing illustrated in...see iF. Fc -.:: ~e parameters PHV ~Anglea ir ratla-’s 1f: ~e2-a: :.s Ange i 8rramLiar t 7 :’aF the gec sctarg, Iar c~t-at2-s sLdstem. t" at -~2 S a C...d--ata p01nts. -a n1g .~tles -3. :a1 et ro~.tlnes -~ f.Pot-’-ie par-ameters ENCM: The dr-crn-at=7 cFf th7e aFfF --e ~.F-.rct icns perFforret Ccnst

Aircraft Landing Dynamic Analysis. Volume 1. Equations of Motion

DTIC Science & Technology

1987-11-09

aQh Xp* (WB 1I H 3 Hh pg esd r f, d X, r B dIp ~ b X aH Hf (a, B + b B 3 b) + F d el 1N + b 60 The fB 2 equation is fBEB N G B f2B (M )CS a 1, N ] B...1 a a TBB (A s a’ Ga 3bg a=I a ah a C + F Hb ( B/eB ) B d 6be d H c + e TBg C l e H e 3 Hh Pg esdr x f ?Hd (a r + b XBr) 8 s ) H 3 f TB 1 b VB BY + g...nondecreasing on [a,b] then f is g integrable on [a,b] (Reference (3)). This is denoted by Jb f dg. In the special case where g = I (the identity

A Trapped Mercury 199 Ion Frequency Standard

DTIC Science & Technology

1981-12-01

ing resul t t h a t could possibly be explained by a for tu i t ious cancel la t ion of t w o e f f ec t s : t h e second order doppler...h a t t h e helium cooling is e f f ec t ive . O the r e f f e c t s of t he helium include nar rower l ines and a la rger s ignal indicat...Desaintfuscien, K. Barjllet, J . Viennet, P. Pet i t , and C. Audoin, Appl. Phys. 24, 107 (1981). 4. R, Ifflaender and G. Werth; Metrologia 13, 167 (1977

Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Big Bear. Volume IV.

DTIC Science & Technology

1980-02-01

C to~~~ II qo 3 4 .. ..N~ V. ...... .V . .N N . .S ... .V .fI . i 0 Wi . .... . 53 .O .00... 0--N. .. ZZ W. I -. 0 -z J~~D &Z av F - -q qWe at s-a...q .a1 2c z oft ew dw- lp- eE- W - 0- fP- M .. 1 ,1e mc VftWU 00, 0%0 0000 - P-PtftoO. -%ffE Uqvv 4i . qwE ft . 04W -f ewF-0 wa rnm~~t.- tol Uw0 f E0

Dynamics of the C/H and C/F exchanges in the reaction of 3P carbon atoms with vinyl fluoride

NASA Astrophysics Data System (ADS)

Lee, Shih-Huang; Chen, Wei-Kan; Chin, Chih-Hao; Huang, Wen-Jian

2013-08-01

Two product channels C3H2F + H and C3H3 + F were identified in the reaction of C(3P) atoms with vinyl fluoride (C2H3F) at collision energy 3.7 kcal mol-1 in a crossed molecular-beam apparatus using selective photoionization. Time-of-flight (TOF) spectra of products C3H2F and C3H3 were measured at 12-16 laboratory angles as well as a TOF spectrum of atomic F, a counter part of C3H3, was recorded at single laboratory angle. From the best simulation of product TOF spectra, translational-energy distributions at seven scattering angles and a nearly isotropic (forward and backward peaked) angular distribution were derivable for exit channel C3H2F + H (C3H3 + F) that has average kinetic-energy release of 14.5 (4.9) kcal mol-1. Products C3H2F + H and C3H3 + F were estimated to have a branching ratio of ˜53:47. Furthermore, TOF spectra and photoionization spectra of products C3H2F and C3H3 were measured at laboratory angle 62° with photoionization energy ranging from 7 eV to 11.6 eV. The appearance of TOF spectra is insensitive to photon energy, implying that only single species overwhelmingly contributes to products C3H2F and C3H3. HCCCHF (H2CCCH) was identified as the dominant species based on the measured ionization threshold of 8.3 ± 0.2 (8.6 ± 0.2) eV and the maximal translational-energy release. The C/H and C/F exchange mechanisms are stated.

The National Shipbuilding Research Program. REAPS 5th Annual Technical Symposium Proceedings. Proceedings of the REAPS Technical Symposium (5th) Held in St. Louis, Missouri in June 27-28, 1978

DTIC Science & Technology

1978-06-01

computer systems is their continual i n c o r p o r a t i o n o f a d d i t i o n a l f u n c t i o n s . Figure 2 represents this... o u t t h i s , on ly pa r t i a l ad hoc so lu t ions can be found. ( R e f e r e n c e 8 )- 4 3 WORLIMIDE SHIPBUILDING COMPUTER SYSTEMS ARE...and which i s ine f f i c i en t to support manually. Before in tegra t ion , th i s da ta f low requ i res manua l ( o r pe rhaps

Ex vivo inhibition of Clostridium botulinum neurotoxin types B, C, E, and F by small molecular weight inhibitors.

PubMed

Montgomery, Vicki A; Ahmed, S Ashraf; Olson, Mark A; Mizanur, Rahman M; Stafford, Robert G; Roxas-Duncan, Virginia I; Smith, Leonard A

2015-05-01

Two small molecular weight inhibitors, compounds CB7969312 and CB7967495, that displayed inhibition of botulinum neurotoxin serotype A in a previous study, were evaluated for inhibition of botulinum neurotoxin serotypes B, C, E, and F. The small molecular weight inhibitors were assessed by molecular modeling, UPLC-based peptide cleavage assay; and an ex vivo assay, the mouse phrenic nerve - hemidiaphragm assay (MPNHDA). While both compounds were inhibitors of botulinum neurotoxin (BoNT) serotypes B, C, and F in the MPNHDA, compound CB7969312 was effective at lower molar concentrations than compound CB7967495. However, compound CB7967495 was significantly more effective at preventing BoNTE intoxication than compound CB7969312. In the UPLC-based peptide cleavage assay, CB7969312 was also more effective against LcC. Both compounds inhibited BoNTE, but not BoNTF, LcE, or LcF in the UPLC-based peptide cleavage assay. Molecular modeling studies predicted that both compounds would be effective inhibitors of BoNTs B, C, E, and F. But CB7967495 was predicted to be a more effective inhibitor of the four serotypes (B, C, E, and F) than CB7969312. This is the first report of a small molecular weight compound that inhibits serotypes B, C, E, and F in the ex vivo assay. Published by Elsevier Ltd.

The pulmonary mesenchymal tissue layer is defective in an in vitro recombinant model of nitrofen-induced lung hypoplasia.

PubMed

van Loenhout, Rhiannon B; Tseu, Irene; Fox, Emily K; Huang, Zhen; Tibboel, Dick; Post, Martin; Keijzer, Richard

2012-01-01

Despite modern treatments, congenital diaphragmatic hernia (CDH) remains associated with variable survival and significant morbidity. The associated pulmonary hypoplasia is a major determinant of outcome. To develop better treatments, improved comprehension of the pathogenesis of lung hypoplasia is warranted. We developed an in vitro cell recombinant model to mimic pulmonary hypoplasia and specifically to investigate epithelial-mesenchymal interactions and to decipher which tissue layer is primarily defective in nitrofen-induced CDH-associated lung hypoplasia. Epithelial cells (E) and fibroblasts (F) were isolated from E19 control ((C)) and nitrofen-induced hypoplastic rat lungs ((N)). Cells were recombined and cultured as either homotypic [(F(C))(E(C)) and (F(N))(E(N))] or heterotypic [(F(C))(E(N)) and (F(N))(E(C))] recombinants. Recombinants containing F(N) fibroblasts had a thickened fibroblast tissue layer and there were fewer organized alveolar-like epithelial structures compared with those in control (F(C))(E(C)) recombinants. These F(N) recombinants exhibited a decrease in terminal deoxynucleotidyl transferase dUTP nick end labeling and cleaved caspase-3 positive cells. Cell proliferation was arrested in recombinants containing F(N) fibroblasts, which also exhibited increased p27(Kip1) and p57(Kip2) expression. In conclusion, fibroblasts, and not epithelial cells, appear to be the defective cell type in nitrofen-induced hypoplastic lungs due to a decreased ability to undergo apoptosis and maintain overall proliferation. This may explain the characteristic pulmonary interstitial thickening and hypoplasia observed in both nitrofen-induced hypoplastic lungs as well as human hypoplastic CDH lungs. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

An Experimental Investigation of Techniques to Suppress Edgetones from Perforated Wind Tunnel Walls

DTIC Science & Technology

1975-08-01

s e e m i t t e d by the p e r f o r a t e d wa l l s h a s b e e n u n d e r s t udy f o r s e v e r a l y e a r s at AEDC. A r e c e...ld at low supe r son i c speeds . Actual s amples of pe r fo ra t ed walls f r o m the t h ree t r a n s o n i c tunnels were t es ted...c t i o n flow and wal l angle that gave a r e a s o n a b l y f la t axia l Mach n u m b e r d i s t r i b u t i o n t h roughou t the

Some constructions on total labelling of m triangles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voon, Chen Huey, E-mail: chenhv@utar.edu.my; Hui, Liew How, E-mail: liewhh@utar.edu.my; How, Yim Kheng, E-mail: tidusyimhome@hotmail.com

2016-06-02

Let mK{sub 3} = (V{sub m}, E{sub m}) be a finite disconnected graph consisting of m disjoint triangles K{sub 3}, where V{sub m} is the set of vertices, E{sub m} is the set of edges and both V{sub m} and E{sub m} are of the same size 3m. A total labelling of mK{sub 3} is a function f which maps the elements in V{sub m} and E{sub m} to positive integer values, i.e. f : V{sub m} ∪ E{sub m} → {1, 2, 3,···}. Let c be a positive integer. A triangle is said have a c-Erdősian triangle labelling ifmore » it is a total labelling f : V{sub m} ∪ E{sub m} → {c, c + 1, ···, c + 6m − 1} such that f (x) + f (y) = f (xy) for any x, y ∈ V{sub m} and an edge xy ∈ E{sub m} joining them. In order to find all the c-Erdősian triangle labelling, a straightforward is to use the exhaustive search. However, the exhaustive search is only able to find c-Erdősian triangle labelling for m ≤ 5 due to combinatorial explosion. By studying the constant sum of vertex labels, we propose a strong permutation approach, which allows us to generate a certain classes of c-Erdősian triangle labelling up until m = 8.« less

7 CFR 271.8 - Information collection/recordkeeping-OMB assigned control numbers.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) 0584-0124 273.11 (a), (b), (c), (d), (e), (f), (h) 0584-0064 273.11 (g) 0584-0334 273.11 (i) (1)-(4... 273.18 (i) 0584-0053 273.21 (a), (c), (e), (f), (g), (h), (i), (j), (m), (p), (q) 0584-0064 274.1 (c...), (h) 0584-0083 278.1 (a), (b), (l) 0584-0008 278.1 (e), (f) 0584-0064 278.4 (b), (c) 0584-0085 278.5...

Shape Representation in V4: Investigating Position-Specific Tuning for Boundary Confirmation with the Standard Model of Object Recognition

DTIC Science & Technology

2004-11-01

s s a c h u s e t t s i n s t ...i t u t e o f t e c h n o l o g y, c a m b r i d g e , m a 0 2 1 3 9 u s a — w w w . c s a i l . m i t . e d u m a ss a c h u se t t s i n...st i t u t e o f t e c h n o l o g y — co m p u t e r sc i e n ce a n d a r t i f ic ia l i n t e l l ig e n ce l a b o ra t o r y

Understanding behavior under nonverbal transitive-inference procedures: Stimulus-control-topography analyses.

PubMed

Galizio, Ann; Doughty, Adam H; Williams, Dean C; Saunders, Kathryn J

2017-07-01

Following training with verbal stimulus relations involving A is greater than B and B is greater than C, verbally-competent individuals reliably select A>C when asked "which is greater, A or C?" (i.e., verbal transitive inference). This result is easy to interpret. Nonhuman animals and humans with and without intellectual disabilities have been exposed to nonverbal transitive-inference procedures involving trained arbitrary stimulus relations. Following the training of A+B-, B+C-, C+D-, and D+E-, B reliably is selected over D (i.e., nonverbal transitive inference). Such findings are more challenging to interpret. The present research explored accounts of nonverbal transitive inference based in transitive inference per se, reinforcement, such as value-transfer theory, and operant stimulus control. In Experiment 1, college students selected B>G following the training of A+B-, B+C-, C+D-///E+F-, F+G-, and G+H- (where///signifies the omission of D+E-). In Experiment 2, college students selected B>G following the training of A+B-, B+C-, C+D-///E+F-, F+G-, and G+X- (where X refers to 10 stimuli that alternated across trials). In Experiment 3, college students selected G>B following the training of Y+B-, B+C-, C+D-///E+F-, F+G-, and G+X- (where Y and X refer to 10 stimuli, respectively, that alternated across trials). These findings are discussed in the context of operant stimulus control by offering an approach based in stimulus B typically acquiring only a select stimulus control topography. Copyright © 2017 Elsevier B.V. All rights reserved.

Finite Element Program for Calculating Flows in Turbomachines with Results for NASA Task-1 Compressor.

DTIC Science & Technology

1982-10-01

CR !PT Jr,4 CF THE FUPEP ELiAEN5 + f ,, 4, S**444444**44*4*4*444++ 44 4.+414++++++4++ + +++4+++44 f 44*4* ++ +444. + 172 FILE: IdES!’ GEN FC4TRAN Al...CLCC-(-"II e(1) 21...X’) STE’T ST’ICT *SSICT 179 FILE: PESI- GEN FCRTPAN Al NAVNL POSTGRAOLATE SCHO󈧣 70C CCITTNJUE P~lUPN C *****+*+*+4*+ *.4+..*4.4...PEtC IN fCCiNFC7Iv1TY IPATP:X, Lr..%L NdCDE NLVhJ3E S STAPT AT ELVEPTIS i.;PIi iR!G~e r~ fANC LC,.% IND) TAV -QSi Mih. C REIC IN 11-E FLEPOENT TypE

47 CFR 95.633 - Emission bandwidth.

Code of Federal Regulations, 2011 CFR

2011-10-01

... is 4 kHz. The authorized bandwidth for emission type A1D or A3E is 8 kHz. The authorized bandwidth for emission type F1D, G1D, F3E or G3E is 20 kHz. (b) The authorized bandwidth for any emission type transmitted by an R/C transmitter is 8 kHz. (c) The authorized bandwidth for emission type F3E or F2D...

47 CFR 95.633 - Emission bandwidth.

Code of Federal Regulations, 2014 CFR

2014-10-01

... is 4 kHz. The authorized bandwidth for emission type A1D or A3E is 8 kHz. The authorized bandwidth for emission type F1D, G1D, F3E or G3E is 20 kHz. (b) The authorized bandwidth for any emission type transmitted by an R/C transmitter is 8 kHz. (c) The authorized bandwidth for emission type F3E or F2D...

47 CFR 95.633 - Emission bandwidth.

Code of Federal Regulations, 2010 CFR

2010-10-01

... is 4 kHz. The authorized bandwidth for emission type A1D or A3E is 8 kHz. The authorized bandwidth for emission type F1D, G1D, F3E or G3E is 20 kHz. (b) The authorized bandwidth for any emission type transmitted by an R/C transmitter is 8 kHz. (c) The authorized bandwidth for emission type F3E or F2D...

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (Daubert Industries, Inc.-Gaylord Industries, Inc.)

DTIC Science & Technology

1993-01-01

a0 m~ ar (0 - a 0 a4 04 H50 4 a 4 C-1 am a C3 L) 0ý an 0 a n c Za4 00 C.ým 4Lo j I N O Nol 0IS)0 cl r- m - anNe t"I ý ý Ll2 an N -z Do~ acca -fN- 0a’J...c to aQ Coo," I "o o) " ’ mC, ,I e nnI to a) ammc)oc Il I I L) o c wo x I Ca u m2 a. U r-7f cc ~ nl.< C0C) -*4~-0na-ao " 0 ELI ao (v acCa ’’ a~al~ nal...Fw IE~ 1. E F1 F4 o F. c4I F 4 F OF. F7 )I - F ~-4 .F 4 F 41) w 10 A F F W)( o4 v7- m ’mo7 l T =444 45 o o .7 c> S . o Lc4 mo - 04 NNr a)0 lo 7 1 7 o

77 FR 29904 - Approval and Promulgation of Implementation Plans; Oregon: Infrastructure Requirements for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

...: (A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M). DATES: This action is effective... elements for the 1997 8-hour ozone NAAQS: (A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M... 1997 ozone NAAQS: (A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), (M). EPA is taking no...

Bi-Spectral Method for Radar Target Recognition

DTIC Science & Technology

2006-12-01

θazimuth=60° and ϕelevation=30° with HV Polarization....................................53 Figure 50 Comparison of Radar Range Profile with Actual...radar systems. A comparison of the NCTR techniques and their relative advantages and disadvantages in target recognition performance is presented. 8...32 f fR i R R c c f fi R R i R R c c A e A e A e ψ ψ π ψ ψ π ψ ψ π ψ ψ

Hazardous Chemical Pump Tests.

DTIC Science & Technology

1980-07-01

hydraulic flow rate is the product of the pump speed and the pump displacement. The pump displacement for each respective pump was constant throughout...speed - rpm T - torque - ft lbs 7= 3.1416 By substituting the product of pump speed and pump displacement for the hydraulic flow rate (Q=NO) in the above...FF:iipr’: iL 40 H FLUID F-’UMPED; FPl H FVIi T’E1l ’HJO I...S Lu FL: H KFITE C F~~:ri FIGURE 2 CC E MT 2, Fi C F . c ;E’C F11 *:;_cl PF fog O ~ \\ 4 1

Joint Force Quarterly. Number 21, Spring 1999

DTIC Science & Technology

1999-03-01

T H E J O I N T W O R L D 113 Doctrine ■ O F F T H E S H E L F 115 Mahan’s Blindness and Brilliance: A Review Essay...er ) U . S . A ir Fo rc e (J oe B el a) 2d M ar in e D iv is io n, C om ba t C am er a (J ac ob A . F ul le r) Marines in Norway for Battle...98. 2d M ar in e D iv is

Condition Based Maintenance Technology Impacts Study for the Military Land Environment

DTIC Science & Technology

2014-08-01

3a, 2g 3b,3m,3j,3e,3d,3f,3a,3c,3i 3c,3d,3h,3n 3d,3h 3e,3k,3i 3f,3h UNCLASSIFIED DSTO-RR-0404 UNCLASSIFIED 158 3g ,3c 3h,4b 3i,3m,3j,CBM...3e -> 3k 3i Egress of 2: 3n -> 3h 4b Egress of 2: 3k -> 3j 5c Egress of 2: 4d -> 3g 3c Egress of 1: 3a -> 2g Egress of 1: 1b -> 2g Egress...Ingress+Egress of 8: 2d 3b 3g 4d 4f -> 3c -> 3d 3h 3n Ingress+Egress of 7: 1b 2e 3a -> 2g -> 3b 2e 2c 2f Ingress+Egress of 7: 2a 2d 6b 6c -> 2b -> 3a

Effect of vitamins C and E on biomarkers of oxidative stress in nonsmokers

PubMed Central

Block, Gladys; Jensen, Christopher D.; Morrow, Jason D.; Holland, Nina; Norkus, Edward P.; Milne, Ginger L.; Hudes, Mark; Dalvi, Tapashi B.; Crawford, Patricia B.; Fung, Ellen B.; Schumacher, Laurie; Harmatz, Paul

2009-01-01

Background Oxidative stress is elevated in obesity, and may be a major mechanism for obesity-related diseases. Methods Nonsmokers (n=396) were randomized to 1000 mg/day vitamin C, 800 IU/day vitamin E, or placebo, for two months. Treatment effect was examined in multiple regression analyses using an intention-to-treat approach. Results Vitamin C (p=0.001) and vitamin E (p=0.043) reduced plasma F2-isoprostanes. In the overall sample, changes from baseline were +6.8%, −10.6%, and −3.9% for placebo, vitamin C, and vitamin E groups, respectively. However, a significant interaction with baseline F2-isoprostane was found. When baseline F2-isoprostane was > 50 μg/mL, vitamin C reduced F2-isoprostane by 22% (p=0.01). Vitamin E reduced it by 9.8% (p=0.46). Below that cut-point, neither treatment produced further reductions. F2-isoprostane > 50 μg/mL was strongly associated with obesity, and was present in 42% of the sample. Change in malondialdehyde concentration was minimal. Discussion These findings suggest a role for vitamin C in reducing lipid peroxidation. Future research on effects of vitamins C or E on plasma F2-isoprostane should limit participants to those with baseline levels > 50 μg/mL. Further studies are needed to establish whether treatment with vitamins C or E in persons with concentrations above that cut-point could slow the development of cardiovascular disease. PMID:18455517

Design Calculations 105’ MLW Structure East Coast Air Combat Maneuvering Range Offshore Kitty Hawk, North Carolina. Volume 1.

DTIC Science & Technology

1976-09-01

of C0 Ca 0 C2 00 ao C 00 CC C3C Q0 C. -f fta -i ft z CI, av CI" O am ame m m f m fmA ’am fu CIn I a l C l Al C l C l C "l C. C lo a D Ti C 5...i 11116 .~4 U-----------V V 3P*Pf .. - 3 F F II $~~Nc~A -1C) a - e v I F. 4.9 za A All - 3. tn 1f0 ow a :Fd ’m I-. m fu 11% 0 fmd fl Ml In -f 0. C...A l -,- 󈧋 - P e- 0 V.. :p ~ AE~ 0 Z 0 u ’ -A - f 1 va- ftA ’I za - .0J2 11 1 2- 0 S1 155wk3inP63 n!N VS 2iOiI 󈧎 -01L 41 1%3 c4 In . * g 11A sraC a

MATREX Simulation Architecture

DTIC Science & Technology

2008-03-10

r e S u p p o r t M i n e s , C o u n t e r m i n e s U n m a n n e d S y s t e m s L o g...i s t i c s N e t w o r k e d E f f e c t s C o m m a n d & C o n t r o l C o n s i s t e n t & H i g h - R e s M i s s i l e M o d e...l i n g C o n s i s t

Affordability of Defense Acquisition Programs

DTIC Science & Technology

2015-02-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Paper P-5243 Redacted February 2015 Affordability of Defense Acquisition Programs...Gene H. Porter, Project Leader Kathleen M. Conley C. Vance Gordon R . Royce Kneece, Jr. Brian Q. Rieksts Alan H. Shaw David M. Tate INSTITUTE FOR DEFENSE...Kathleen M. Conley C. Vance Gordon R . Royce Kneece, Jr. Brian Q. Rieksts Alan H. Shaw David M. Tate I N S T I T U T E F O R D E F E N S E A N A L Y S E

Personality and Politics: The Untold Story of Robert S. McNamara and Curtis E. Lemay

DTIC Science & Technology

2012-06-01

James H. Douglas, Jr . F.F. Everest William C. Garland Harry E. Goldsworthy Brian S. Gunderson Ernest C. Hardin, Jr . Michael J. Ingelido Leon W...Schriever Alton D. Slay Frederick H. Smith F.H. Smith, Jr . Guyford H. Steven Maxwell D. Taylor John W. Vogt Adriel N. Williams E.M. Zuckert...of Oahu, Hawaii. 22 Curtis E. LeMay Oral History Interview conducted by Edgar F. Puryear, Jr . 17

FORCEnet Net Centric Architecture - A Standards View

DTIC Science & Technology

2006-06-01

SHARED SERVICES NETWORKING/COMMUNICATIONS STORAGE COMPUTING PLATFORM DATA INTERCHANGE/INTEGRATION DATA MANAGEMENT APPLICATION...R V I C E P L A T F O R M S E R V I C E F R A M E W O R K USER-FACING SERVICES SHARED SERVICES NETWORKING/COMMUNICATIONS STORAGE COMPUTING PLATFORM...E F R A M E W O R K USER-FACING SERVICES SHARED SERVICES NETWORKING/COMMUNICATIONS STORAGE COMPUTING PLATFORM DATA INTERCHANGE/INTEGRATION

Organizational Diagnosis: A Review and a Proposed Method

DTIC Science & Technology

1974-09-01

r IL YC I . I I I.j .. L 0 ie k.. LJt’IJ1, I C 10 k II I 63 , IIV. II I7 L ls L If e L-ue .J *7 C I 64 F2 C .1 F1 .1I 2Is 30a nI j1 ,33...L,. Ii 68 V.p In I? W.’ 1rvI ý I 4 VIi . 1 U.1,.1o. vi le . r : Wi It IC Lt’ ’ ofI -!Z 0’ c .. *’ .fNNN" f.,(4%ZI0CN Ii VI %j I Z.Z U, IJ 4-I4-. e A c ...FZ4WW4 i ,. e . I. 4:. Il L Ir -7, e %nI: I -IL, I r ,I . c ’ ’D

Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern

DOE Office of Scientific and Technical Information (OSTI.GOV)

El Tayebi, H.M.; Omar, K.; Hegy, S.

2013-05-10

Highlights: •The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. •E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. •miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. •miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. •miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In thismore » study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.« less

Rare emergence of drug resistance in HIV-1 treatment-naïve patients after 48 weeks of treatment with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide.

PubMed

Margot, Nicolas A; Kitrinos, Kathryn M; Fordyce, Marshall; McCallister, Scott; Miller, Michael D; Callebaut, Christian

2016-03-01

Tenofovir alafenamide (TAF), a novel prodrug of the NtRTI tenofovir (TFV), delivers TFV-diphosphate (TFV-DP) to target cells more efficiently than the current prodrug, tenofovir disoproxil fumarate (TDF), with a 90% reduction in TFV plasma exposure. TAF, within the fixed dose combination of elvitegravir /cobicistat / emtricitabine (FTC)/TAF (E/C/F/TAF), has been evaluated in one Phase 2 and two Phase 3 randomized, double-blinded studies in HIV-infected treatment-naive patients, comparing E/C/F/TAF to E/C/F/TDF. In these studies, the TAF-containing group demonstrated non-inferior efficacy to the TDF-containing comparator group with 91.9% of E/C/F/TAF patients having <50 copies/mL of HIV-1 RNA at week 48. An integrated resistance analysis across these three studies was conducted, including HIV-1 genotypic analysis at screening, and genotypic/phenotypic analysis for patients with HIV-1 RNA>400 copies/mL at virologic failure. Pre-existing primary resistance-associated mutations (RAMs) were observed at screening among the 1903 randomized and treated patients: 7.5% had NRTI-RAMs, 18.2% had NNRTI-RAMs, and 3.4% had primary PI-RAMs. Pre-treatment RAMs did not influence treatment response at Week 48. In the E/C/F/TAF group, resistance development was rare; seven patients (0.7%, 7/978) developed NRTI-RAMs, five of whom (0.5%, 5/978) also developed primary INSTI-RAMs. In the E/C/F/TDF group, resistance development was also rare; seven patients (0.8%, 7/925) developed NRTI-RAMs, four of whom (0.4%, 4/925) also developed primary INSTI-RAMs. An additional analysis by deep sequencing in virologic failures revealed minimal differences compared to population sequencing. Overall, resistance development was rare in E/C/F/TAF-treated patients, and the pattern of emergent mutations was similar to E/C/F/TDF.

Proceedings of Advanced Planning Briefing for Industry. Part 1

DTIC Science & Technology

1965-12-01

t h e flow o f in format ion and i d e a s must be both t o you and from you. We thus welcome t h e oppo r tun i t y o f p r e sen t i...megawatt, l i g h t wa te r moderated and c o o l e d , h i g h l y e n r i c h e d uranium , the rmal t y p e t h a t i s c o n s t a n t l y...a l s . Our c u r r e n t programs i n b e r y l l i u m and i n uranium have n o t t h e e x t e n s i v e - n e s s o f t h e e a r l i

Dover AFB Delaware. Revised Uniform Summary of Surface Weather Observations. Parts A-F

DTIC Science & Technology

1974-08-07

8217 C IN @1 iN 2,2 71 SE 5, _ I _____. ws . 2,. A,’ , S _____ __ . _____ ____Sw . , 2, - :j ih , I. I I 12 .. SSWA NABE O2 .O 1.4 a CIO.S921 0 soi 4... SY HrsOMthTprat u MMA c Pe. H. AFD573 t ) 91660R 77 0 41 0 2-408b- 0_F_32_F_67_F73_F _8__F_ 93_ _ol I’- a ii-E 29(,06 899 3*CE/MA296.C4.19 -4- -E _1

Regulatory and structural properties differentiating the chromosomal and the bacteriophage-associated Escherichia coli O157:H7 Cu, Zn superoxide dismutases.

PubMed

D'Orazio, Melania; Scotti, Raffaella; Nicolini, Laura; Cervoni, Laura; Rotilio, Giuseppe; Battistoni, Andrea; Gabbianelli, Roberta

2008-10-01

Highly virulent enterohemorrhagic Escherichia coli O157:H7 strains possess three sodC genes encoding for periplasmic Cu, Zn superoxide dismutases: sodC, which is identical to the gene present in non-pathogenic E. coli strains, and sodC-F1 and sodC-F2, two nearly identical genes located within lambdoid prophage sequences. The significance of this apparent sodC redundancy in E. coli O157:H7 has not yet been investigated. We report that strains deleted of one or more sodC genes are less resistant than the wild type strain to a challenge with hydrogen peroxide, thus confirming their involvement in the bacterial antioxidant apparatus. To understand if the different sodC genes have truly overlapping functions, we have carried out a comparison of the functional, structural and regulatory properties of the various E. coli O157:H7 SodC enzymes. We have found that the chromosomal and prophagic sodC genes are differentially regulated in vitro. sodC is exclusively expressed in aerobic cultures grown to the stationary phase. In contrast, sodC-F1 and sodC-F2 are expressed also in the logarithmic phase and in anaerobic cultures. Moreover, the abundance of SodC-F1/SodC-F2 increases with respect to that of SodC in bacteria recovered from infected Caco-2 cells, suggesting higher expression/stability of SodC-F1/SodC-F2 in intracellular environments. This observation correlates with the properties of the proteins. In fact, monomeric SodC and dimeric SodC-F1/SodC-F2 are characterized by sharp differences in catalytic activity, metal affinity, protease resistance and stability. Our data show that the chromosomal and bacteriophage-associated E. coli O157:H7 sodC genes have different regulatory properties and encode for proteins with distinct structural/functional features, suggesting that they likely play distinctive roles in bacterial protection from reactive oxygen species. In particular, dimeric SodC-F1 and SodC-F2 possess physico-chemical properties which make these enzymes more suitable than SodC to resist the harsh environmental conditions which are encountered by bacteria within the infected host.

Broadband Two-Photon Absorption Characteristics of Highly Photostable Fluorenyl-Dicyanoethylenylated [60] Fullerene Dyads (Postprint)

DTIC Science & Technology

2016-05-14

practical use. It is crucial since a i 1. ( ) i it il tauto eri resonances at the bridging C61Hα- [ ( ) ] t t f - j t - ( ) f ll r l s - r ri e si i l... i , lea i t t e f r ati f a f ll -c j ate f r f 6 acce t r ( ) a r ( ), as arke in purple. This resulted in an extended A–D conjugation length a d...absorbing properties. Scheme 1. Synthesis of C60(>CPAF-Cn) 1-Cn (n = 4, 9, 12, or 18) dyads. Reagents and conditions: i . C60, DBU, toluene, rt, 5.0 h; ii

76 FR 56130 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... NAAQS dated October 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M...), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions thereof. DATES: Written..., K, L, M. November 30, 2007 G April 3, 2008 A, B, C, D(ii), E, F, G, H, J, K, L, M. April 16, 2010 G...

76 FR 47062 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions... CAA section 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions... sections 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions thereof...

Elliptic Integrals in the Minkowski Plane

DTIC Science & Technology

1991-05-09

factorial Pochhammer notation F(a + k) (a)k - (a) Let F(a, b , c denote the hypergeometric function. Assume c - a - b = d , where d is a positive...integer. Then in a neighborhood of C = 1 , ((d) F(a+ b+d) d-1 (a)n (b)n )n(22) F(a , b , a + b + d , () = E~ )rb+ 0-’)n( ) r(a +d) r(b +d) n =O0( ’d’ n...axes a , b and eccentriaty e = c where c = Ta2 - b2 . Let P denote one of the foci of the ellipse. Then (26) 1 1 1 2 and(26) ar+(K, P) 2 -er F(- 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blackfield, Donald T.; Poole, Brian R.

N2F is a C/C++ code used to calculate the far zone electromagnetic (EM) field, given E and H near zone field data. The method used by N2F can be found in Ref. 1 and 2. N2F determines the far field E Φ and E θ in spherical coordinates for near zone data calculated in either Cartesian or Cylindrical geometry.

U.S. EPA, Pesticide Product Label, GOWAN PROMETRYNE 4L, 02/02/1990

EPA Pesticide Factsheets

2011-04-21

... l·to'"TI('''· I' t..'('lr::'· t-!!') tI-( f;~1 ~rFt Sl·.4~~f" P"'c' ,~ : _'" _ 1't,..."i(C orr'" C'''f'' po:: ... 1,'1'~"". 0' f ",~"'tt:: ~~, l"eC" .... ... l ; . " . ~IOO"'I,so"d DOM'''''f' ...

Nonlinear Burning Stability of Solid Propellants.

DTIC Science & Technology

1983-12-31

de f()dO dX dO dX - dx d o d do d 20"--- - f( e ) 2- dX dX dX dX2 Therefore, the steady thermal profile for the same nondimensio- nal temperature...PF ,) C ( e ) de -H )-(1-r )Fo+q (0 gis 0 -C c o out s At the crossing of qg,s(P,R) with qg,s(P,Fo,®_ ), steady solutions R(P, Fo,1 ) vs qg,s are singled...PAGE (Wbrm Dets Entered) Is.-7 *0*" UNCLASSIFIED . " E C U R ITV C L A S S IF IC A T IO N O F T 0 IS P A G rwhI e D o ra E m, -- 20. Continued

Detection of Translational Equivalence

DTIC Science & Technology

2001-05-01

13L_6�4 1 5 68739 :;pE6 9 C:@O7365 H8735$:XF87fES>132�E6T9:> :;9`?�C:’¿ � dTÀÄE~;W9C:’> M739 E1)132x9C:@1 65$:;9;H�8;9 >ES6...Y47 @O4 HR@O739 :<JH8;-E65�7c<RAT6873eE~4ÈF> 1 5 > 73e’e?E65�9 :4C6RE~Q$H: `®�CREO;EO;’�:;9 EP@P@SH8;9 > M739 :<­�TAY736�: U873e’FR

Worldwide U.S. Active Duty Military Deaths. Alphabetical Index by Name, 1 October 1979 Through 30 September 1994

DTIC Science & Technology

1994-09-30

DE LME NDO G E R A R D O MAR I GZA A I R F O R C E D E LMUNDO L I LY F E D E R I S NAVY D E LOACH B O B B Y D E A N A I R F ORCE D E LOGE B...YAN LAMON EAR LE JAME S ARTHUR EAR LEY KEN W EAR LEY R OB E R T WI L L IAM J R EAR LS M I CHAE L G EAR LS OMAR DALE EAR LY BE N JAMIN J R...8 9 B R OOK LYN E 0 4 2 2 F e b 8 2 KEN TON E 0 7 14 D e c 9 1 R OCKH I L L 0 0 2 1 4 J u l 8 1 T E XAS C I T Y E 0 6 24 Oc t 7 9

78 FR 49116 - Airworthiness Directives; Eurocopter France Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

..., B2, B3, BA, C, D, and D1 helicopters; and Model AS355E, F, F1, F2, N, and NP helicopters. The... certain Eurocopter Model AS350B, B1, B2, B3, BA, C, D, and D1 and Model AS355E, F, F1, F2, N, and NP... pilot if certain regulatory recordkeeping requirements are met. As such, AD 2011-22-05 currently...

49 CFR 173.52 - Classification codes and compatibility groups of explosives.

Code of Federal Regulations, 2013 CFR

2013-10-01

... or hypergolic liquid) E 1.1E1.2E 1.4E Article containing a secondary detonating explosive substance....1E 1.1F 1.1G 1.1J 1.1L 9 1.2 1.2B 1.2C 1.2D 1.2E 1.2F 1.2G 1.2H 1.2J 1.2K 1.2L 10 1.3 1.3C 1.3F 1.3G...

Nernst and Seebeck effects in HgTe/CdTe topological insulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yuan; Song, Juntao; Li, Yu-Xian, E-mail: yxli@mail.hebtu.edu.cn

2015-03-28

The Seebeck and Nernst effects in HgTe/CdTe quantum wells are studied using the tight-binding Hamiltonian and the nonequilibrium Green's function method. The Seebeck coefficient, S{sub c}, and the Nernst coefficient, N{sub c}, oscillate as a function of E{sub F}, where E{sub F} is the Fermi energy. The Seebeck coefficient shows peaks when the Fermi energy crosses the discrete transverse channels, and the height of the nth peak of the S{sub c} is [ln2/(1/2 +|n|)] for E{sub F} > 0. For the case E{sub F} < 0, the values of the peaks are negative, but the absolute values of the first five peaks are themore » same as those for E{sub F} > 0. The 6th peak of S{sub c} reaches the value [ln2/1.35] due to a higher density of states. When a magnetic field is applied, the Nernst coefficient appears. However, the values of the peaks for N{sub c} are all positive. For a weak magnetic field, the temperature suppresses the oscillation of the Seebeck and Nernst coefficients but increases their magnitude. For a large magnetic field, because of the highly degenerate Landau levels, the peaks of the Seebeck coefficient at position E{sub F}=−12, 10, 28meV, and Nernst coefficient at E{sub F}=−7, 10meV are robust against the temperature.« less

75 FR 22508 - Airworthiness Directives; Eurocopter France Model AS350B, BA, B1, B2, B3, C, D, and D1; AS 355E...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... Airworthiness Directives; Eurocopter France Model AS350B, BA, B1, B2, B3, C, D, and D1; AS 355E, F, F1, F2, N... (b) None. Applicability (c) This AD applies to Model AS350B, BA, B1, B2, B3, C, D and D1; and AS 355E..., both dated November 16, 2005, is approved by the Director of the Federal Register as of May 14, 2010...

Is the F-35B the Right Fit for the MAGTF?

DTIC Science & Technology

2012-05-01

F-35C Lightning II, consolidating three separate models of tactical aircraft into a fifth generation strike fighter. The F-35 provides "Day One...current replacement solution for the Marine Corps is the F-35B and F-35C Lightning II, consolidating three separate models of tactical aircraft into a...66.9 million. This aircraft has been operationally tested and is a familiar model of aircraft to the Marine Corps (see Appendix E). The F/A-18E or F

A Manual for the Prediction of Blast and Fragment Loadings on Structures

DTIC Science & Technology

1981-08-15

ives , assembles exp los ives components i n t o assemblies , does more i n s p e c t i o n s , and f i n a l l y packages and s h i p s t h...4100, Los Alamos S c i e n t i f i c Laboratory, Un ive r s i ty of C a l i f o r n i a , Los Alamos , New Mexico, February 1970. 4.29 " I n t e...Massachusetts I n s t i t u t e of Technology, 1976. B- 7 Bdzi l , J. B. and Davis, W. C., "Time-Dependent Detonat ions," J.A-5926-MS, Los Alamos S c i

Confirmatory Analytic Tests of Three Causal Models Relating Job Perceptions to Job Satisfaction.

DTIC Science & Technology

1984-12-01

Perceptions ~Job SatisfactionD I~i- Confirmatory Analysi s Precognitive Postcognitive L ft A e S T R A f T I ( C O n" " n ," , V fV f f vv r e # d o i t c e...in the causal order, and job perceptions and job satisfaction are reciprocally related; (b) a precognitive -recursive model in which job perceptions...occur after job satisfaction in the causal order and are effects but not causes of job satisfaction; and (c) a precognitive DD FOR 1473 EDITION 01O NOV

Fiscal Year 2010 Budget Request. Summary Justification

DTIC Science & Technology

2009-05-01

FISCAL YEAR 2010 BUDGET REQUEST S U M M A R Y J U S T I F I C A T I O N • M A Y 2 0 0 9 U N I T E D S T A T E S D E P A R T M E N T O F D...E F E N S E Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average...Justification 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

HasF, a TolC-homolog of Serratia marcescens, is involved in energy-dependent efflux.

PubMed

Kumar, Ayush; Worobec, Elizabeth A

2005-06-01

A tolC-like gene (hasF) was identified upon scanning the incomplete database of the S. marcescens genome. This gene was amplified using PCR and cloned in the pUC18 vector to yield pUCHF. Sequencing of the S. marcescens tolC-like hasF gene and subsequent amino acid sequence prediction revealed approximately 80% amino acid homology with the Escherichia coli TolC. A tolC-deficient strain of E. coli (BL923) containing pUCHF/hasF was analyzed for susceptibility to fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), chloramphenicol, sodium dodecyl sulfate (SDS), and ethidium bromide. Antibiotic susceptibility assays of the E. coli tolC-deficient mutant BL923 demonstrated a 64-fold increase in resistance to SDS and ethidium bromide upon introduction of the S. marcescens tolC-like hasF gene. No change was observed for susceptibility to fluoroquinolones and chloramphenicol. Ethidium bromide accumulation assays performed using E. coli BL923:pUCHF established the role of the S. marcescens hasF gene product in proton gradient-dependent efflux.

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (Bituminous Paving, Inc.-Datum Maching Services, Inc.)

DTIC Science & Technology

1993-01-01

Fa U ~ 4 0 F0 co00 F 0~ 0~~~ z CC FF; F F (0 FEFn E3 >w 40 pa P4 PO FPi 40~~ ~ 0 HC F F 0 Z 4 F < OF C Z N N z w to F3 C) i3Z 0 CO Q F. 0 r. F0 0 4h...3331*7.30-.4 0 ~ ~ ~ ~ ~ ~ ~ ~ a m x3 Fx3. (󈧥- F3 3 0 (3 .~0 IHC ~ - r 2 00 0.00 F ’> F .0-.. 0co 33.. 13 F 0 1 ~ CO F- 3 F - 2431~~~~~~~~~~~ U)4X 0o F...0( F3 00 0 n ;r3 000 r0o ( -- N r.’- m -- a, m w "D 00 N C> (n0r 0 0) 0 0 , ~ 1 (0.5 0 4CNC, i n ) ~ 04 3 I- F I~~~~C C,) F 0 0o’e

Thermal Properties of Mineralized and Non Mineralized Type I Collagen in Bone

DTIC Science & Technology

2002-04-01

Heredial, E. Villarreal", J. Ocotldn-Flores2, A. L. Gomez-Cortes’, F. J. Aranda-Manteca 5, E. Orozco’ and L. Bucio’. lInstituto de Fisica , UNAM, Ciudad... Investigaciones en Materiales, UNAM, Ciudad Universitaria, Coyoacan. C.P. 04510. Mexico. D.F.41nstituto de Investigaciones Antropologicas, UNAM...Universitaria, Coyoacan. C.P. 01000, Mexico. D.F.2Centro de -instrumentos, UNAM, Ciudad Universitaria, Coyoacan. C.P. 04510. Mexico. D.F.3Instituto de

Automation of the Marine Corps Planning Process

DTIC Science & Technology

2014-06-01

I & IV P ro b le m Fr am in g C h ap te r II  JT C W  C P O F  IO Sv 1 C O A D e ve lo p m e n t C O A W ar -G am e C O A C o m p...S  JA D IC S  P SS -S O F  St ri ke Li n k  C ID N E  IO Sv 2  IO Sv 3  M ar in e Li n k Command & Control C h ap te r II I

Regular Inversion of the Divergence Operator with Dirichlet Boundary Conditions on a Polygon,

DTIC Science & Technology

1987-04-01

E c- xC 0 Czt C- -- &C -nC CL C~ E C - U U C U C0 V C ( C CC C L 6- - C C- 1 -CLL r = .c L C A C *C CCC F 4 C CC> C C 4D C3 1 ZC -’ c OC.LL fUC I...Iil Moreover by Lemmna 2.1, there is a single cons aiit C such that IIIIIPpV Chi 1 /, p e < CII, 1 2/P p. holds for all such 9. Thus / . af l( I-,0)1

Defense Logistics Agency Disposition Services Needs to Improve Demilitarization Program Self-Assessment Evaluations - Redacted

DTIC Science & Technology

2016-12-20

Program Self -Assessment Evaluations I N T E G R I T Y  E F F I C I E N C Y  A C C O U N T A B I L I T Y  E X C E L L E N C E Mission Our mission...Project No. D2016-D000RD-0057.000) │ i Results in Brief Defense Logistics Agency Disposition Services Needs to Improve Demilitarization Program Self ...mutilation contractor3 in Holbrook, New York, the two sites we visited. However, for self -assessment evaluations4 at three DLA Centralized

75 FR 31340 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-03

... 1997 PM 2.5 NAAQS, dated October 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K... made such findings for the 1997 8- hour ozone NAAQS on March 27, 2008 (73 FR 16205) and on October 22... December 13, 2007 A, B, C, D(ii), E, F, A, B, C, D(ii), E, F, G, H, J, K, L, M. G, H, J, K, L, M. March 12...

75 FR 27510 - Approval and Promulgation of Air Quality Implementation Plans; State of West Virginia; Section...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

... 1997 PM 2.5 NAAQS dated October 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K... 16205) and on October 22, 2008 (73 FR 62902) for the 1997 PM 2.5 NAAQS. These completeness findings did....5 2006 PM2.5 December 3, 2007 A, C, D(ii), E, F, G, J, K, L. April 3, 2008 A, C, D(ii), E, F, J, L...

Survey of Laser-Produced Pressure and Impulse Data

DTIC Science & Technology

1988-01-01

Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA C02 Wavelength: 10.6 pm Pulse energy: to...Mecanique des Fluides de Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA CO2 Wavelength...34 Authors : C.L. Bohn, M.D. Stephen, F. Eng, J.C. Souders, G.A. Brost , T.F. Deaton, B.W. Duvall, and J.T. Tinsley Citation: "Mechanical coupling of an

New species of Cenozoic benthic foraminifera from the former British Petroleum micropalaeontology collection

NASA Astrophysics Data System (ADS)

Fox, Lyndsey R.; Stukins, Stephen; Hill, Tom; Bailey, Haydon

2018-01-01

This paper describes four new Cenozoic, deep-water benthic foraminifera from the reference collections at the Natural History Museum in London. The focus is on selected calcareous taxa that are of stratigraphical and/or palaeoecological significance for academic and industrial-related activities. Alabamina heyae (urn:lsid:zoobank.org:act:1E8A66E9-1F4C-4B61-BA97-6E0ECCD0173E), Nonion cepa (urn:lsid:zoobank.org:act:9F36350A-1E49-4D69-B2CC-C83F343E2952), Uvigerina kingi (urn:lsid:zoobank.org:act:C36C89C2-2E65-4FF6-9368-C169B4591995) and Lenticulina stewarti (urn:lsid:zoobank.org:act:485AE871-CECA-44E8-ABD1-BAE2961FFD59) are described with new illustrations. Their biostratigraphic and palaeoecological significance is briefly discussed.

Limit Cycle Solutions of Reaction-Diffusion Equations.

DTIC Science & Technology

1980-06-01

simply matching terms of o(.En), the essential factor in obtaining -OLIveLgence is to mix O(- n -1 ) and O(Cn ) terms. The remainder of this section...determine vn we mix up the terms of the second system, defining vn by: dv0 - I I[ K- I-F(Uo)]V0 - I F (uo)F Uo) , (3.4b) dvn0 (E K F’(u )v0 I FF...0). Substitution of 00 u ’Zi-F- c(aO)E into g =0 gives and c(c() kfc ( CP): 3< 40’ from which cQO() > I b(ool for all 0( follows, giving a majorant

Maneuvering Aerothermal Technology (MAT) Program. A Method for Coupled Three-Dimensional Inviscid and Integral Boundary Layer Calculations

DTIC Science & Technology

1982-05-01

impervious, flat plate. The friction coefficient and Stanton number for laminar flow are: 0.245 (4.24) 2 e 27. I. V C , tD 0.22 (4.25) and for...A I0 I iISl~i Ai i iI# 2.- cIC ,C ,c c , C ;C - 0Ki of IWc -K.lm0. wowFC 0p-- U. 4~~.0 w mN N a’ IN g e.F .0 f cfýN@-,4 a No pc c % 2 C-, r-’, 4F -6

Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer.

PubMed

Duska, L R; Hamblin, M R; Bamberg, M P; Hasan, T

1997-01-01

The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab')2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab')2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. OC125F(ab')2 gave highest tissue values of 125I, followed by cationic OC125F(ab')2 PIC; other species were much lower. The amounts of c(e6) delivered per gram of tumour were much higher for cationic OC125F(ab')2 PIC than for other species. The results indicate that cationic charge stimulates the endocytosis and lysosomal degradation of the OC125F(ab')2-pl-c(e6) that has bound to the i.p. tumour. Positively charged PICs may have applications in the i.p. photoimmunotherapy of minimal residual ovarian cancer.

Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter.

PubMed Central

Jansen-Durr, P; Wintzerith, M; Reimund, B; Hauss, C; Kédinger, C

1990-01-01

EIa-dependent transactivation of the adenovirus EIIa early (EIIaE) promoter is correlated with the activation of the cellular transcription factor E2F. In this study we identified a cellular protein, C alpha, that is distinct from E2F and that binds two sites in the EIIaE promoter, one of which overlaps with the proximal E2F binding site of the EIIaE promoter. The possible involvement of C alpha in the EIa responsiveness of this promoter is discussed. Images PMID:2139142

Mutations of Electrons as Constituents of Hadrons

NASA Astrophysics Data System (ADS)

Driscoll, R. B.

1997-04-01

Conjecture (C) 1: Coulomb-charged constituents of electron (e) are attracted to its barycentre by lepto-strong force F=K/r^2+f; f is stably perturbative for r < the "radius" of e. An exterior magnetic field (MF) with gradient (G) secularly perturbs the eccentricities but not the energies of the constituents' orbits, changing the spin (s) and magnetic moment (μ) of e. (C) 2: F coheres two or more e's dynamically with r approximately equal to the "radius" of e. The resulting MF and G at each e oscillate. Stable values of s and μ result for each e which differs from the atomic values. Binding energies change the masses of the e's. A hadron results. (C) 3: An e similarly may bind to a proton to form a Rutherford- Santilli neutron. The proton is negligibly mutated.(References: H. Dehmelt, Science 247, 539 (1990); T.E. Phipps, Jr., Heretical Verities (Classic Non-fiction Library, Urbana, 1986); R.M. Santilli, Hadronic Mechanics (Ukrainian Academy of Sciences, Kiev, 1995 and 1996), 3 volumes.)

Spectroscopic characterization, antimicrobial activity and molecular docking study of novel azo-imine functionalized sulphamethoxazoles

NASA Astrophysics Data System (ADS)

Sahu, Nilima; Mondal, Sudipa; Naskar, Kaushik; Mahapatra, Ananya Das; Gupta, Suvroma; Slawin, Alexandra M. Z.; Chattopadhyay, Debprasad; Sinha, Chittaranjan

2018-03-01

[SMXsbnd Ndbnd Nsbnd C6H3sbnd (p-OH)(msbnd CHO)] (1) reacts with ArNH2 to synthesize Schiff bases, [SMXsbnd Ndbnd Nsbnd C6H3sbnd (psbnd OH)(msbnd HCdbnd Nsbnd Ar)] (Ar = sbnd C6H5 (2a), sbnd C6H4sbnd psbnd CH3 (2b), sbnd C6H4sbnd psbnd OCH3 (2c), sbnd C6H4sbnd psbnd Cl (2d), sbnd C6H4sbnd psbnd NO2 (2e), sbnd C10H7 (2f)) and the products have been assessed for antibacterial properties against Gram positive bacteria, B. subtillis: IC50 (μg/ml): 39.2 (1), 60.1 (2a), 64.0 (2b), 85.6 (2c), 55.1 (2d), 88.4 (2e) and 65.1 (2f); and Gram negative bacteria, E. coli: IC50 (μg/ml): 159.0 (1), 151.4 (2a), 155.3 (2b), 140 (2c), 156.0 (2d), 153.5 (2e) and 157 (2f). The cell line toxicity (Vero cells) has also been evaluated with these compounds and EC50 (μg/ml) values are 129.9 (1), 74.2 (2a) and 93.0 (2b), 191.9 (2c), 99.1 (2d), 93.2 (2e) and 62.0 (2f). The anti-viral efficiency against harpies virus (HSVsbnd 1F ATCC-733) infection demonstrates that the compound 1 has highest selectivity index (CC50/EC50), 5.06 than the compounds 2a-f (CC50/EC50: 1.18 (2a), 1.42 (2b), 3.50 (2c), 1.45 (2d), 1.58 (2e), 1.29 (2f)). The compounds have been spectroscopically characterized and the structural confirmation has been established in one case by single crystal X-ray diffraction studies of 2c. In silico Molecular Docking study has been done using optimized geometries of the compounds to search the most favored binding mode of these drugs and hence useful to explain their competitive drug efficiency.

Annual Trauma Anesthesia and Critical Care Symposium (6th) Held in Baltimore, MD on 20-23 May 1993

DTIC Science & Technology

1993-10-01

increasing intracranial pressure, and increased metabolic demand (e.g. seizures or fever ), however, may be attenuated with appropriate care. In...Dyspnea C. Cyanosis D. Headache E. Irritability F. Confusion G. Tachycardia S H. Pyrexia I. Petechial Rash VII. Clinical Findings (Severe F.E.S.) A...Frank Pulmonary Edema B. Convulsions/Coma C. ECG Showing Right Heart Strain D. Pyrexia E. Petechial Hemorrhage F. Jaundice G. Renal Impairment S O

Comparison of three dimeric 18F-AlF-NOTA-RGD tracers.

PubMed

Guo, Jinxia; Lang, Lixin; Hu, Shuo; Guo, Ning; Zhu, Lei; Sun, Zhongchan; Ma, Ying; Kiesewetter, Dale O; Niu, Gang; Xie, Qingguo; Chen, Xiaoyuan

2014-04-01

RGD peptide-based radiotracers are well established as integrin αvβ3 imaging probes to evaluate tumor angiogenesis or tissue remodeling after ischemia or infarction. In order to optimize the labeling process and pharmacokinetics of the imaging probes, we synthesized three dimeric RGD peptides with or without PEGylation and performed in vivo screening. Radiolabeling was achieved through the reaction of F-18 aluminum-fluoride complex with the cyclic chelator, 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). Three imaging probes were synthesized as (18)F-AlF-NOTA-E[c(RGDfK)]2, (18)F-AlF-NOTA-PEG4-E[c(RGDfK)]2, and (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2. The receptor binding affinity was determined by competitive cell binding assay, and the stability was evaluated by mouse serum incubation. Tumor uptake and whole body distribution of the three tracers were compared through direct tissue sampling and PET quantification of U87MG tumor-bearing mice. All three compounds remained intact after 120 min incubation with mouse serum. They all had a rapid and relatively high tracer uptake in U87MG tumors with good target-to-background ratios. Compared with the other two tracers, (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2 had the highest tumor uptake and the lowest accumulation in the liver. The integrin receptor specificity was confirmed by co-injection of unlabeled dimeric RGD peptide. The rapid one-step radiolabeling strategy by the complexation of (18)F-aluminum fluoride with NOTA-peptide conjugates was successfully applied to synthesize three dimeric RGD peptides. Among the three probes developed, (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2 with relatively low liver uptake and high tumor accumulation appears to be a promising candidate for further translational research.

Approximate Analysis of an Unreliable M/M/2 Retrial Queue

DTIC Science & Technology

2007-03-01

F ’ corresponds to p_6|i 44 F =m^2*x^2*( l +2* a +2*m+2*x)/Den; 45 46 %Stores the above probabilities into a vector 47 CondProb = [ A B C D E F ]; 48...53 LambdaHat = x*qf*B + ( l *qa+2*x*qf)* C + ( l *qa+x*qf)*D + l *qa* F ; 54 %The ’death’ rate 55 ThetaHat = theta*( A + B + E); 56 %The level of the orbit is...2 + λ + g , (4.2) where g = λ3 2 + 3λ + 2θ · F ( a + 1, b + 1, c + 1; λ 2 ) F

[Morphologic changes in cultures of different tissues exposed to the toxins of C1. perfringens types B, C, E and F].

PubMed

Ermakova, M P; Zemlianitskaia, E P

1975-11-01

There were revealed morphological peculiarities of the action of C1. perfringens toxins, types B, C, D, E and F on the cultures of fibroblasts of chick embryo, amniotic cells and intestinal tissue. The toxin type B was characterized by a marked vocuolization of the cell cytoplasm; the action of the toxin of type C was expressed in the swelling of the nuclei and the lysis of the chromatine substance, the toxin of type E casued kariorhexis, and the toxin of type F--hyperchromatosis of the nuclei. All the cultures proved to be insensitive to the toxin of type D. Peculiarity of the morphological affection of the cells permitted to differentiate toxin of type B in the cultures of the fibroblasts of chick embryo, whereas the toxins of types C, E and F--in the cultures of the amniotic cells under control of the reaction of neutralization with the homologous antitoxic sera.

Thermophysical and radiation properties of high-temperature C4F8-CO2 mixtures to replace SF6 in high-voltage circuit breakers

NASA Astrophysics Data System (ADS)

Zhong, Linlin; Cressault, Yann; Teulet, Philippe

2018-03-01

C4F8-CO2 mixtures are one of the potential substitutes to SF6 in high-voltage circuit breakers. However, the arc quenching ability of C4F8-CO2 mixtures is still unknown. In order to provide the necessary basic data for the further investigation of arc quenching performance, the compositions, thermodynamic properties, transport coefficients, and net emission coefficients (NEC) of various C4F8-CO2 mixtures are calculated at temperatures of 300-30 000 K in this work. The thermodynamic properties are presented as the product of mass density and specific heat, i.e., ρCp. The transport coefficients include electrical conductivity, viscosity, and thermal conductivity. The atomic and molecular radiation are both taken into account in the calculation of NEC. The comparison of the properties between SF6 and C4F8-CO2 mixtures is also discussed to find their differences. The results of compositions show that C4F8-CO2 mixtures have a distinctive advantage over other alternative gases e.g., CF3I and C3F8, because the dissociative product (i.e., C4F6) of C4F8 at low temperatures has a very high dielectric strength. This is good for an arc quenching medium to endure the arc recovery phase. Compared with SF6, C4F8-CO2 mixtures present lower ρCp at temperatures below 2800 K and larger thermal conductivity above 2800 K. Based on the position of peaks in thermal conductivity, we predict that the cooling of C4F8-CO2 arc will be slowed down at higher temperatures than that of SF6 arc. It is also found that the mixing of CO2 shows slight effects on the electrical conductivity and NEC of C4F8-CO2 mixtures.

Development of Specialized Equipment to Measure Piezoelectric Coefficients of Polymer Piezoelectric Materials,

DTIC Science & Technology

1980-02-22

definition g.l = (Voc/t)(F/wt) = field/stress 2. C =KT K 1E w/t (parallel plate capacitdnce formula) ’. VL = Voc Cx’/CL for CL > Cx 4.v g/wF Kt Eoewlt...V = (g3 1 /w)F 2. V L =(Cg/c,.v oc 3. V =(Cg/CL)(g31/w)F 4. Vstd = "d3 3"/C std F 5. V L/ Vst d = (C /C ) (g ’)(C /"d " )Sg L 31 std 33 01. 6. R (in...34 and the second T " e’hicial Note No. 1 - Theory of the use of Channel Products (’DT (X() d., meteor to measure d31 direct.]y on Piezoelect.rlc Ceramic

Heat Transfer and Thermal Stability of Alternative Aircraft Fuels. Volume 2. Appendices.

DTIC Science & Technology

1983-11-01

eoea a aS mOOaeO 0OO eoO eoo oee I:pp ’D ed.V 5 0-4 * ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ OC Cd Fr .04F-V4,FFq.CdSIF0ddF-0-.VW4 o0 F- 01 w* .40 v A4F -C 4...oo a oft oees 0 e s sD1 .ees,, a r . .4.%44Zci.4 por.. 0 -~~~C vi 9 1oN,.ee~ * 0 0 a 0a a g 0l as e Cc,. a aa C. Ca 0 C, 0 c,0 c 00 0 011a 00 I 0 .0

The Colletotrichum acutatum species complex

PubMed Central

Damm, U.; Cannon, P.F.; Woudenberg, J.H.C.; Crous, P.W.

2012-01-01

Colletotrichum acutatum is known as an important anthracnose pathogen of a wide range of host plants worldwide. Numerous studies have reported subgroups within the C. acutatum species complex. Multilocus molecular phylogenetic analysis (ITS, ACT, TUB2, CHS-1, GAPDH, HIS3) of 331 strains previously identified as C. acutatum and other related taxa, including strains from numerous hosts with wide geographic distributions, confirmed the molecular groups previously recognised and identified a series of novel taxa. Thirty-one species are accepted, of which 21 have not previously been recognised. Colletotrichum orchidophilum clusters basal to the C. acutatum species complex. There is a high phenotypic diversity within this complex, and some of the species appear to have preferences to specific hosts or geographical regions. Others appear to be plurivorous and are present in multiple regions. In this study, only C. salicis and C. rhombiforme formed sexual morphs in culture, although sexual morphs have been described from other taxa (especially as laboratory crosses), and there is evidence of hybridisation between different species. One species with similar morphology to C. acutatum but not belonging to this species complex was also described here as new, namely C. pseudoacutatum. Taxonomic novelties: New combinations - Colletotrichum limetticola (R.E. Clausen) Damm, P.F. Cannon & Crous, C. lupini (Bondar) Damm, P.F. Cannon & Crous, C. salicis (Fuckel) Damm, P.F. Cannon & Crous. New species - C. acerbum Damm, P.F. Cannon & Crous, C. australe Damm, P.F. Cannon & Crous, C. brisbanense Damm, P.F. Cannon & Crous, C. cosmi Damm, P.F. Cannon & Crous, C. costaricense Damm, P.F. Cannon & Crous, C. cuscutae Damm, P.F. Cannon & Crous, C. guajavae Damm, P.F. Cannon & Crous, C. indonesiense Damm, P.F. Cannon & Crous, C. johnstonii Damm, P.F. Cannon & Crous, C. kinghornii Damm, P.F. Cannon & Crous, C. laticiphilum Damm, P.F. Cannon & Crous, C. melonis Damm, P.F. Cannon & Crous, C. orchidophilum Damm, P.F. Cannon & Crous, C. paxtonii Damm, P.F. Cannon & Crous, C. pseudoacutatum Damm, P.F. Cannon & Crous C. pyricola Damm, P.F. Cannon & Crous, C. rhombiforme Damm, P.F. Cannon & Crous, C. scovillei Damm, P.F. Cannon & Crous, C. sloanei Damm, P.F. Cannon & Crous, C. tamarilloi Damm, P.F. Cannon & Crous, C. walleri Damm, P.F. Cannon & Crous. Typifications: Epitypifications - C. acutatum J.H. Simmonds, C. limetticola (R.E. Clausen) Damm, P.F. Cannon & Crous, C. nymphaeae (Pass.) Aa, C. phormii (Henn.) D.F. Farr & Rossman, C. salicis (Fuckel) Damm, P.F. Cannon & Crous. Lectotypifications - C. nymphaeae (Pass.) Aa, C. orchidearum Allesch. PMID:23136458

U.S. Army Military Surface Deployment and Distribution Command Needs to Improve its Oversight of Labor Detention Charges at Military Ocean Terminal Sunny Point

DTIC Science & Technology

2016-03-16

whistleblower protection, please see the inside back cover. I N T E G R I T Y  E F F I C I E N C Y  A C C O U N T A B I L I T Y  E X C E L L...USTRANSCOM United States Transportation Command Whistleblower Protection U.S. Department of Defense The Whistleblower Protection Enhancement Act of...2012 requires the Inspector General to designate a Whistleblower Protection Ombudsman to educate agency employees about prohibitions on retaliation

Electron impact elastic and excitation cross-sections of the isomers of C4F6 molecule for plasma modeling

NASA Astrophysics Data System (ADS)

Gupta, Dhanoj; Song, Mi-Young; Baluja, K. L.; Choi, Heechol; Yoon, Jung-Sik

2018-06-01

We report the calculations of elastic (along with its symmetry components) and electronic excitation cross sections by electron impact of the three isomers of C4F6, namely, hexafluoro-1,3-butadiene (1,3-C4F6), hexafluoro-2-butyne (2-C4F6), and hexafluorocyclobutene (c-C4F6) belonging to the point groups C2, D3d, and C2v, respectively, using the R-matrix approach. The electron energy range is from 0.01 eV to 12 eV. We have employed the cc-pVTZ basis set for C and F atoms to generate self-consistent field molecular orbitals to construct the target states for all the isomers included in our calculations. All the target states are constructed by including correlation effects in a configuration interaction (CI) approach. The target properties such as vertical excitation energies and dipole moment of all the isomers are in reasonable agreement with the literature values. Differences in the cross sections of these isomers are strongly influenced by the effect of correlation and polarization effects and their geometrical extent. We have included the ground state and many excited states of each isomer in the trial wave function of the entire scattering system. The resulting elastic cross sections are compared with the available experimental results. The agreement is reasonably good for energies above 5 eV. The shape resonances detected at 2.57, 2.95, and 3.20 eV for c-C4F6, 1,3-C4F6, and 2-C4F6 isomers are associated with the negative anion formation of C3F3- as observed in the mass spectrometry experiments. We have also performed 1-state CI calculation for all the isomers that include only the correlated ground state. The position of resonances shifts to lower energies as the number of target states is increased compared to 1-state calculation for all the isomers. The elastic cross section for 2-C4F6 isomer is larger than the other isomers because of its larger spatial extent. The present cross section data are important for plasma simulation and modeling, especially related to fluorocarbon plasma.

(H, Li)Br and LiOH Solvation Bonding Dynamics: Molecular Nonbond Interactions and Solute Extraordinary Capabilities.

PubMed

Sun, Chang Q; Chen, Jiasheng; Gong, Yinyan; Zhang, Xi; Huang, Yongli

2018-01-25

We resolved the O:H-O bond transition from the mode of ordinary water to its hydration in terms of its phonon stiffness (vibration frequency shift Δω), order of fluctuation (line width), and number fraction (phonon abundance), f x (C) = N hyd /N total . The f x (C) follows f H (C) = 0, f Li (C) ∝ f OH (C) ∝ C, and f Br (C) ∝ 1 - exp(-C/C 0 ) toward saturation with C being the solute concentration. The invariant df x (C)/dC suggests that the solute forms a constantly sized hydration droplet without responding to interference of other ions because its hydrating H 2 O dipoles fully screen its electric field. However, the number inadequacy of the highly ordered hydration H 2 O dipoles partially screens the large Br - . The Br - then interacts repulsively with other Br - anions, which weakens its electric field and the f Br (C) approaches saturation at higher solute concentration. The consistency in the concentration trend of the f LiBr (C), the Jones-Dole viscosity η(C), and the surface stress of LiBr solution clarifies their common origin of ionic polarization. The resultant energy of the solvent H-O exothermic elongation by O: ⇔ :O repulsion and the solute H-O endothermic contraction by bond-order deficiency heats up the LiOH solution. An estimation of at least 0.15 eV (160% of the O:H cohesive energy of 0.1 eV) suggests that the H-O elongation is the main source heating up the solution, while the molecular motion, structure fluctuation, or even evaporation dissipates energy caped at 0.1 eV.

Premalignant Genetic and Epigenetic Alterations in Tubal Epithelium from Women with BRCA1 Mutations

DTIC Science & Technology

2010-10-14

Homo sapiens , clone IMAGE:5590287, mRNA Unknown 1.8 .0044 3.0...RT-PCR W T -F T B 1- F T B 1 C an ce r 0 2 4 6 8 10 R el at iv e Q u an ti fi ca ti o n CDKN1C Array W T -F T B 1- F T B 1 C an ce r 0 100 200 300...S p o t In te n si ty CDKN1C RT-PCR W T -F T B 1- F T B 1 C an ce r 0.0 0.2 0.4 0.6 0.8 R el at iv e Q u an ti fi ca ti o n CYP3A5 Array W T

(DURIP) MIMO Radar Testbed for Waveform Adaptive Sensing Research

DTIC Science & Technology

2015-06-17

OH 43210 -1016 31-Aug...Ohio State University Columbus, OH Foreword Microwave radar systems are crucial components of any standoff sensor system due to their all-weather...976LP 3E E N 1 R D 2 R E F 3 V R X 4 HV 5 N/C1 6 N/C2 7 N/C3 8 N /C 4 9 N /C 5 10 V R 11 N /C 6 12 N/C7 13 N/ C8 14 VDD 15 N/C9 16 GND_2 17 C 9 10uF C

Experimental and Theoretical Studies of High Power Plasma Filled Backward Wave Oscillators

DTIC Science & Technology

1991-02-01

excitation and amplification plasma may have a phase velocity vph ,, - c, allowing it of electromagnetic waves. This last area has been referred to be more...and (5): e x p lic i t f o r m ir f 12 ( + A f / f , 12 ) ] ( f=f(cosL,G) (2) Vph Cos_ I(B 2 -4C&f) _2-B]I2C), (4) where f is the frequency of the

The Mira Variable S Orionis: Relationships Between the Photosphere, Molecular Layer, Dust Shell, and SiO Maser Shell at 4 Epochs

DTIC Science & Technology

2007-01-01

C ., Gray, M. D., Humphreys, E. M. L ., Braithwaite, M. F ., & Field, D. 1995, A & A , 302, 797 Feast, M. W., Glass, I. S., Whitelock, P. A ., & Catchpole... C ., Bester, M., Degiacomi, C . G., Greenhill, L . J., & Townes, C . H. 1994, AJ, 107, 1469 Desmurs, J. F ., Bujarrabal, V., Colomer, F ., & Alcolea, J...2003, Proc. SPIE, 4838, 89 Gray, M. D., & Humphreys, E. M. L . 2000, New Astron., 5, 155 Haniff, C . A ., Scholz, M., & Tuthill,

Cross sections for electron collision with difluoroacetylene

NASA Astrophysics Data System (ADS)

Gupta, Dhanoj; Choi, Heechol; Kwon, Deuk-Chul; Yoon, Jung-Sik; Antony, Bobby; Song, Mi-Young

2017-04-01

We report a detailed calculation of total elastic, differential elastic, momentum transfer and electronic excitation for electron impact on difluoroacetylene (C2F2) molecules using the R-matrix method at low energies. After testing many target models, the final results are reported for the target model that gave the best target properties and predicted the lowest value of the shape resonance. The shape resonance is detected at 5.86 eV and 6.49 eV with the close-coupling and static exchange models due to 2Πg (2B2g, 2B3g) states. We observed that the effect of polarization becomes prominent at low energies below 4 eV, decreasing the magnitude of the elastic cross section systematically as it increases for C2F2. We have also computed elastic cross sections for C2H2, C2F4 and C2H4 with a similar model and compared with the experimental data for these molecules along with C2F2. General agreement is found in terms of the shape and nature of the cross section. Such a comparison shows the reliability of the present method for obtaining the cross section for C2F2. The calculation of elastic scattering cross section is extended to higher energies up to 5 keV using the spherical complex optical potential method. The two methods are found to be consistent, merging at around 12 eV for the elastic scattering cross section. Finally we report the total ionization cross section using the binary encounter Bethe method for C2F2. The perfluorination effect in the shape and magnitude of the elastic, momentum transfer and ionization cross sections when compared with C2H2 showed a similar trend to that in the C2H4-C2F4 and C6H6-C6F6 systems. The cross-section data reported in this article could be an important input for the development of a C2F2 plasma model for selective etching of Si/SiO2 in the semiconductor industry.

Proceedings of the International Conference on the Numerical Simulation of Plasmas (14th) Held in Annapolis, Maryland on September 3-6, 1991

DTIC Science & Technology

1991-01-01

2 - tý a .5 .= . A ’. 2 0’.. o SS ’.. . t I -. .5 :. C, 0 Oý 0 r go %C a -0 c SS 2L 2E "t-iocogo" 0 IS F6 a c So a,, 3 IL So E 2 Q Qo’ V E r r 0c c...4 ar 0 -C ’ aCCa 0 W. , US w .2 00 ~ i; E 2 ~ . o.Z-. - w a~C -0 e0 E4 Em 12 *U - -.E 2 c - act , 0 3 2. , =- b ! .. E0 E 2- ccZZ cT, w~. ýt 0 w C...00 o- c 00 F6 ~ -02 C -4 a. 71 if )A 1 G a -2 - a d= . Cc 00 -V -0 0 P- . -- Z - 2 - q 0 0J2 2 a c x -a WO.~. 0 C;W n-a- - 0 1 o ao RR 0 if * . -I

Tripolar Stability: The Future of Nuclear Relations Among the United States, Russia, and China

DTIC Science & Technology

2002-09-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S D E F E N S E T H R E A T R E D U C T I O N A G E N C Y Tripolar Stability: The Future of... Tripolar Stability: The Future of Nuclear Relations Among the United States, Russia, and China Brad Roberts PREFACE Since the creation of the...here were first sketched out in a symposium convened at IDA on July 28 on nuclear tripolarity , where thoughtful presentations were made on facets

Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer.

PubMed Central

Duska, L. R.; Hamblin, M. R.; Bamberg, M. P.; Hasan, T.

1997-01-01

The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab')2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab')2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. OC125F(ab')2 gave highest tissue values of 125I, followed by cationic OC125F(ab')2 PIC; other species were much lower. The amounts of c(e6) delivered per gram of tumour were much higher for cationic OC125F(ab')2 PIC than for other species. The results indicate that cationic charge stimulates the endocytosis and lysosomal degradation of the OC125F(ab')2-pl-c(e6) that has bound to the i.p. tumour. Positively charged PICs may have applications in the i.p. photoimmunotherapy of minimal residual ovarian cancer. PMID:9062404

Proton NMR studies of the electronic structure of ZrH/sub x/

NASA Technical Reports Server (NTRS)

Attalla, A.; Bowman, R. C., Jr.; Craft, B. D.; Venturini, E. L.; Rhim, W. K.

1982-01-01

The proton spin lattice relaxation times and Knight shifts were measured in f.c.c. (delta-phase) and f.c.t. (epsilon-phase) ZrH/sub x/ for 1.5 or = to x or = to 2.0. Both parameters indicate that N(E/sub F/) is very dependent upon hydrogen content with a maximum occurring at ZrH1 83. This behavior is ascribed to modifications in N(E/sub F/) through a fcc/fct distortion in ZrH/sub x/ associated with a Jahn-Teller effect.

CONUS (Continental United States) Omega/VLF Data Collection: Flight Test.

DTIC Science & Technology

1983-12-01

ET AL. DEC 83 UNCLASSIFIED DOT/ FR /P-83/35 DOT-FRI-S-C-i80 F/G 17/7 ? mEEEEEEEEEoiE mEEEEEmongooEE EEEEEEEEEEmhEE EhhhEEEEEEEEEE EEEEEEEEEomhhEE...Florida 33406 M T p fR p r e ei dC w 12. Sp..-.; e Hom e and Address FI A R..EPOR Department of Transportation Federal Aviation Administration 1 . 800...PDocssory Unit .413 9.MIIIU L . .N-iply et rRgt M IFISI/WL E IIE WTWAT/o) Eastor ost or e bankd dgendnt ponthe llos fr atmatc squetialselctin o 1 F

Effectiveness of Incendiary Ammunition Against Aircraft Fuel Tanks

DTIC Science & Technology

1948-10-05

r ker~e::le fillei ranks, Fer lhese figures, aU funcUoning t>Srf:Jraticne were c.;:mstdered for projectiles :m- pcting en previot :.Sly ur.Car.::aged... weight in u:-.fts of lCOJ grair.s wf"’ filler weight in units C: 100 grains As a typical example 3f the use of the formula, ccmsider the T36E2" CaL...0,60 rouaC str!k!ng at 2100 f:.jsec. ?:J.e p:-cjectile weight is l: 50 grair.s and t~e fUler weight is 92 grains. Tte !::•:-mula yidds "𔃺.80 The

Role of C-Terminal Cysteine Residues of Aspergillus fumigatus Allergen Asp f 4 in Immunoglobulin E Binding

PubMed Central

Ramachandran, Harikrishnan; Banerjee, Banani; Greenberger, Paul A.; Kelly, Kevin J.; Fink, Jordan N.; Kurup, Viswanath P.

2004-01-01

Among the several allergens cloned and expressed from Aspergillus fumigatus, Asp f 4 is a major one associated with allergic bronchopulmonary aspergillosis (ABPA). The structure-function relationship of allergens is important in understanding the immunopathogenesis, diagnosis, and treatment of allergic diseases. These include the epitopes, conformational or linear, deletion of the N or C terminus or both N and C termini, and glycosylation or nonglycosylation, all of which affect immune responses. Similarly, the role of cysteine residues present in allergens may yield useful information regarding the conformational structure of allergens and the immunoglobulin E (IgE) epitope interaction. Such information may help in developing new strategies towards immunotherapy. In order to define the role of cysteine in the interaction of the antibody with Asp f 4, we have constructed mutants by selectively deleting cysteine residues from the C-terminal region of the Asp f 4. Immunological evaluation of these engineered recombinant constructs was conducted by using sera from patients with ABPA, Aspergillus skin test-positive asthmatics, and healthy controls. The results demonstrate strong IgE binding with Asp f 4 and two truncated mutants, Asp f 41-234 (amino acids [aa] 1 to 234) and Asp f 41-241 (aa 1 to 241), while another mutant, Asp f 41-196 (aa 1 to 196), showed reactivity with fewer patients. The result suggests that deletion of cysteines and the alteration of IgE epitopes at the C-terminal end resulted in conformational changes, which may have a potential role in the immunomodulation of the disease. PMID:15013973

Simulation of Critical Materials Resource Strategies. Volume 2. Appendix D - Data Base through Scenario 23.

DTIC Science & Technology

1983-09-13

4 T .. . 7 8 , -t I j: S" VA 4 ~ 0 7 C ) I* C S. 0 7 W-ei 9It 9. 0 T./COEF 0. 1333 C) 13:: 0 121) 0 5 3-: 0...a: ,-’:, .uIr.re’.l I ,:, !, IIF,,;r.,:’,e~ f cc,,trllir A R : i,:, of -,ny ot.le-r Media t’-di~ a 1-, or, 2 3 4 5 6. 7 8 3 0 S-.r OEF 0. O’° ).-. 0...F - - COMMOD I TY (U’ 1TS- ) (UilT .3.) f % L ATED ORMP’eFT. At.ITY r; :- - - FALT F:. 4 E-: - 4 7 402 5 8 . 5 3413. 1 7 A ’C EL 2n -, -- ". . ’

High-level ab initio predictions for the ionization energy, bond dissociation energies, and heats of formations of iron carbide (FeC) and its cation (FeC+).

PubMed

Lau, Kai-Chung; Chang, Yih-Chung; Lam, Chow-Shing; Ng, C Y

2009-12-31

The ionization energy (IE) of FeC and the 0 K bond dissociation energies (D(0)) and the heats of formation at 0 K (DeltaH(o)(f0)) and 298 K (DeltaH(o)(f298)) for FeC and FeC(+) are predicted by the single-reference wave function based CCSDTQ(Full)/CBS approach, which involves the approximation to the complete basis set (CBS) limit at the coupled cluster level up to full quadruple excitations. The zero-point vibrational energy (ZPVE) correction, the core-valence electronic corrections (up to CCSDT level), spin-orbit couplings, and relativistic effects (up to CCSDTQ level) are included in the calculations. The present calculations provide the correct symmetry predictions for the ground states of FeC and FeC(+) to be (3)Delta and (2)Delta, respectively. We have also examined the theoretical harmonic vibrational frequencies of FeC/FeC(+) at the ROHF-UCCSD(T) and UHF-UCCSD(T) levels. While the UHF-UCCSD(T) harmonic frequencies are in good agreement with the experimental measurements, the ROHF-UCCSD(T) yields significantly higher harmonic frequency predictions for FeC/FeC(+). The CCSDTQ(Full)/CBS IE(FeC) = 7.565 eV is found to compare favorably with the experimental IE value of 7.59318 +/- 0.00006 eV, suggesting that the single-reference-based coupled cluster theory is capable of providing reliable IE prediction for FeC, despite its multireference character. The CCSDTQ(Full)/CBS D(0)(Fe(+)-C) and D(0)(Fe-C) give the prediction of D(0)(Fe(+)-C) - D(0)(Fe-C) = 0.334 eV, which is consistent with the experimental determination of 0.3094 +/- 0.0001 eV. The D(0) calculations also support the experimental D(0)(Fe(+)-C) = 4.1 +/- 0.3 eV and D(0)(Fe-C) = 3.8 +/- 0.3 eV determined by the previous ion photodissociation study. The present calculations also provide the DeltaH(o)(f0)(DeltaH(o)(f298)) predictions for FeC/FeC(+). The analysis of the correction terms in these calculations shows that the core-valence and valence-valence electronic correlations beyond CCSD(T) wave function and the relativistic effects make significant contributions to the calculated thermochemical properties of FeC/FeC(+). For the experimental D(0) and DeltaH(o)(f0) values of FeC/FeC(+), which are not known to high precision, we recommend the CCSDTQ(Full)/CBS predictions [D(0)(Fe-C) = 3.778 eV, D(0)(Fe(+)-C) = 4.112 eV, DeltaH(o)(f0)(FeC) = 760.8 kJ/mol and DeltaH(o)(f0)(FeC(+)) = 1490.6 kJ/mol] based on the ZPVE corrections using the experimental vibrational frequencies of FeC and FeC(+).

Rotation of Subunits During Catalysis by Escherichia coli F_1-ATPase

NASA Astrophysics Data System (ADS)

Duncan, Thomas M.; Bulygin, Vladimir V.; Zhou, Yuantai; Hutcheon, Marcus L.; Cross, Richard L.

1995-11-01

During oxidative and photo-phosphorylation, F_0F_1-ATP synthases couple the movement of protons down an electrochemical gradient to the synthesis of ATP. One proposed mechanistic feature that has remained speculative is that this coupling process requires the rotation of subunits within F_0F_1. Guided by a recent, high-resolution structure for bovine F_1 [Abrahams, J. P., Leslie, A. G., Lutter, R. & Walker, J. E. (1994) Nature (London) 370, 621-628], we have developed a critical test for rotation of the central γ subunit relative to the three catalytic β subunits in soluble F_1 from Escherichia coli. In the bovine F_1 structure, a specific point of contact between the γ subunit and one of the three catalytic β subunits includes positioning of the homolog of E. coli γ-subunit C87 (γC87) close to the β-subunit 380DELSEED386 sequence. A βD380C mutation allowed us to induce formation of a specific disulfide bond between β and γC87 in soluble E. coli F_1. Formation of the crosslink inactivated βD380C-F_1, and reduction restored full activity. Using a dissociation/reassembly approach with crosslinked βD380C-F_1, we incorporated radiolabeled β subunits into the two noncrosslinked β-subunit positions of F_1. After reduction of the initial nonradio-active β-γ crosslink, only exposure to conditions for catalytic turnover results in similar reactivities of unlabeled and radiolabeled β subunits with γC87 upon reoxidation. The results demonstrate that γ subunit rotates relative to the β subunits during catalysis.

40 CFR 52.173 - Visibility protection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2... the State regulation is disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E.... 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2), (H), (I)(1...

40 CFR 52.173 - Visibility protection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2... the State regulation is disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E.... 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2), (H), (I)(1...

40 CFR 52.173 - Visibility protection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2... the State regulation is disapproved; (iii) Reg. 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E.... 19.1505 (A)(1) and (2), (B), (C), (D)(1) and (2), (E), (F)(1) and (2), (G)(1) and (2), (H), (I)(1...

A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125

PubMed Central

Bijlmakers, Marie-José; Teixeira, João M. C.; Boer, Roeland; Mayzel, Maxim; Puig-Sàrries, Pilar; Karlsson, Göran; Coll, Miquel; Pons, Miquel; Crosas, Bernat

2016-01-01

The activity of RING ubiquitin ligases (E3s) depends on an interaction between the RING domain and ubiquitin conjugating enzymes (E2), but posttranslational events or additional structural elements, yet largely undefined, are frequently required to enhance or regulate activity. Here, we show for the ubiquitin ligase RNF125 that, in addition to the RING domain, a C2HC Zn finger (ZnF) is crucial for activity, and a short linker sequence (Li2120-128) enhances activity. The contribution of these regions was first shown with truncated proteins, and the essential role of the ZnF was confirmed with mutations at the Zn chelating Cys residues. Using NMR, we established that the C2HC ZnF/Li2120-128 region is crucial for binding of the RING domain to the E2 UbcH5a. The partial X-ray structure of RNF125 revealed the presence of extensive intramolecular interactions between the RING and C2HC ZnF. A mutation at one of the contact residues in the C2HC ZnF, a highly conserved M112, resulted in the loss of ubiquitin ligase activity. Thus, we identified the structural basis for an essential role of the C2HC ZnF and conclude that this domain stabilizes the RING domain, and is therefore required for binding of RNF125 to an E2. PMID:27411375

Dynamics of δ-dopant redistribution during heterostructure growth

NASA Astrophysics Data System (ADS)

Pankratov, E. L.

2007-06-01

It has recently been shown that growth of a multilayer structure with one or more delta-layers at high temperature leads to spreading and asymmetrization of the dopant distribution [see, for example, E.F.J. Schubert, Vac. Sci. Technol. A. 8, 2980 (1990), A.M. Nazmul, S. Sugahara, M. Tanaka, J. Crystal Growth 251, 303 (2003); R.C. Newman, M.J. Ashwin, M.R. Fahy, L. Hart, S.N. Holmes, C. Roberts, X. Zhang, Phys. Rev. B 54, 8769 (1996); E.F. Schubert, J.M. Kuo, R.F. Kopf, H.S. Luftman, L.C. Hopkins, N.J. Sauer, J. Appl. Phys. 67, 1969 (1990); P.M. Zagwijn, J.F. van der Veen, E. Vlieg, A.H. Reader, D.J. Gravesteijn, J. Appl. Phys. 78, 4933 (1995); W.S. Hobson, S.J. Pearton, E.F. Schubert, G. Cabaniss, Appl. Phys. Lett. 55, 1546 (1989); Delta Doping of Semiconductors, edited by E.F. Schubert (Cambridge University Press, Cambridge, 1996); Yu.N. Drozdov, N.B. Baidus', B.N. Zvonkov, M.N. Drozdov, O.I. Khrykin, V.I. Shashkin, Semiconductors 37, 194 (2003); E. Skuras, A.R. Long, B. Vogele, M.C. Holland, C.R. Stanley, E.A. Johnson, M. van der Burgt, H. Yaguchi, J. Singleton, Phys. Rev. B 59, 10712 (1999); G. Li, C. Jagadish, Solid-State Electronics 41, 1207 (1997)]. In this work analytical and numerical analysis of dopant dynamics in a delta-doped area of a multilayer structure has been accomplished using Fick's second law. Some reasons for asymmetrization of a delta-dopant distribution are illustrated. The spreading of a delta-layer has been estimated using example materials of a multilayer structure, a delta-layer and an overlayer.

Corrosion of Metals and Alloys in the Deep Ocean

DTIC Science & Technology

1976-02-01

ilicr I c.ir of c,\\poi54trc in scaIwa;ter. 4 50 4,, ( , iiC 4I. l ’ t l ’ ’𔃾 F -- .=.= - ---------- .P. Lii 51 5. 2 ff.. I- EDx airliisois jify: 53 t~.1...000000000 .5 ______ WWW ztzNO Nz ~ _ ffz z O’f - - - - - -- -. - 6 CL A -~W xxmw CL. Z5- y L0.YC 6 .a .cc 0 m % f E E 0" lr~ ______t q f! lin It l l t" ~t...o, -- . = - -- - .- - s : fr -’_ - = 3,; - - ? . -- -_ = r . - ,.- -r r - , "_ - 1 - - - ---. v - i r ¢. .- . *i". € z ,.- - - C / ; " ,t J

Absorption Analysis Applied to Neutrons in a Thermal Column

DTIC Science & Technology

1960-11-01

determined experimentally, 4’ . can be obtained from the inverse transform of A(B). The desired quantity, f (E) , is then obtained by use of Eq. (7); f(E-dE...where a and d were found to be 16. 76 and 0. 0256, respectively. This transform is also found in Table 1. The inverse transform of Eq. (20) is 2:d-e...yielded this fit was [b F-b fx -ax] T(x)--.e 1.1 Equation 1. 1 yielded the inverse transform , Ŕ when (I-a)(0 S(71) =, b e[b4c- c(2-a)- 4(Z-a)] 1.2 e

Proposed Department of Defense Policy on Air Installations Compatible Use Zones

DTIC Science & Technology

1973-06-01

34 F-3 HIOHT MOW • 1! F-100 afterburner 2A B-52H military 2C-5 ! F-101 F-6 C/KC-135A... afterburner F-6 F-89 MONT MOW 10 F-8 F-94 F-ll T-38 B^7 military 2D A-5 B-58 military mONT MOW • HMNT MOUP * F-SO...imlitarv 2B-5 F S4F F MG F-104 military 2A-5 F-10« F-86E, F. H F-4B. C " F-86V \\ F-K HMNT MOW 4 B-67 F-3 afterburner

[Extracellular fluid, plasma and interstitial volume in cirrhotic patients without clinical edema or ascites].

PubMed

Noguera Viñas, E C; Hames, W; Mothe, G; Barrionuevo, M P

1989-01-01

Extracellular fluid volume (E.C.F.) and plasma volume (P.V.), were measured with sodium sulfate labeled with 35I and 131I human serum albumin, respectively, by the dilution technique in control subjects and in cirrhotic patients without clinical ascites or edema, renal or hepatic failure, gastrointestinal bleeding or diuretics. Results are expressed as mean +/- DS in both ml/m2 and ml/kg. In normal subjects E.C.F. (n = 8) was 7,533 +/- 817 ml/m2 (201.3 +/- 182 ml/kg), P.V. (n = 11) 1,767 +/- 337 ml/m2 (47.2 +/- 9.3 ml/kg), and interstitial fluid (I.S.F.) (n = 7) 5,758 +/- 851 ml/m2 (Table 2). In cirrhotic patients E.C.F. (n = 11) was 10,318 +/- 2,980 ml/m2 (261.7 +/- 76.8 ml/kg), P.V. (n = 12) 2,649 +/- 558 ml/m2 (67.7 +/- 15.6 ml/kg) and I.S.F. (n = 11) 7,866 +/- 2,987 ml/m2 (Table 3). Cirrhotic patients compared with normal subjects have hypervolemia due to a significant E.C.F. and P.V. expansion (p less than 0.02 and less than 0.001 respectively) (Fig. 1). Reasons for E.C.F. and P.V. abnormalities in cirrhotic patients may reflect urinary sodium retention related to portal hipertension which stimulates aldosterone release or enhanced renal tubular sensitivity to the hormone. However, it is also possible that these patients, in the presence of hypoalbuminemia (Table 1), have no clinical edema or ascites due to increased glomerular filtration, suppressed release of vasopressin, increased natriuretic factor, and urinary prostaglandin excretion, in response to the intravascular expansion, all of which increased solute and water delivery to the distal nephron and improved renal water excretion. We conclude that in our clinical experience cirrhotic patients without ascites or edema have hypervolemia because of a disturbance in E.C.F.

Water Quality Management Studies, Alabama River, R. E. ’Bob’ Woodruff, William ’Bill’ Dannelly and Claiborne Lakes - August-December 1977.

DTIC Science & Technology

1983-03-01

AS RlIVE A MILE 306 - - HO(, ARM SlY A l FIE M 300 51Hp#F N WAS I f DISC"ARGE Ru29 2704-" R Milk 2 AND 9bVEL 08KIHATSO 3r AI DISARtE R IA AL272 HOIG f...VZ TF (OIt.CHARCfE* RivCP Mid ?Ř ANC) 2WA RESP9C1,VELY OAONTGOe.ERY AL RVF MAIL( 285: ’NfOANCL.V-4F ;PFi A’ N. I E R MILE "U- 16 6 6 A A w- 0 .A...RIVENA M:f .F ’, 1 t50 X10 MILLERS FERRYI (rC AND DAMRIVERF Mr f 1 BF AFIU CREF. RVf P MILEF 12.3 PURFSdfY CREE RIVER MiIF III/ 90 (,LAISOPNE LOC(-K AND

EnviroAtlas Tree Cover Configuration and Connectivity, Water Background Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The 1-meter resolution tree cover configuration and connectivity map categorizes tree cover into structural elements (e.g. core, edge, connector, etc.). Source imagery varies by community. For specific information about methods and accuracy of each community's tree cover configuration and connectivity classification, consult their individual metadata records: Austin, TX (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B29D2B039-905C-4825-B0B4-9315122D6A9F%7D); Cleveland, OH (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B03cd54e1-4328-402e-ba75-e198ea9fbdc7%7D); Des Moines, IA (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B350A83E6-10A2-4D5D-97E6-F7F368D268BB%7D); Durham, NC (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BC337BA5F-8275-4BA8-9647-F63C443F317D%7D); Fresno, CA (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B84B98749-9C1C-4679-AE24-9B9C0998EBA5%7D); Green Bay, WI (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B69E48A44-3D30-4E84-A764-38FBDCCAC3D0%7D); Memphis, TN (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BB7313ADA-04F7-4D80-ABBA-77E753AAD002%7D); Milwaukee, WI (https://edg.epa.gov/metadata/catalog/search/resource/details.page?u

Velocity and Attenuation Profiles in the Monterey Deep-Sea Fan

DTIC Science & Technology

1987-12-01

a. 11 o n i n and depth. Sol ’^ a 11 e i"i u a 11 o >) a i::> 1 n Ci sediment for each of the f i...i. n c t ion o f f r e q u e n c; y...estimate of sea floor depth was obtained from an oceano - graphic map of the Monterey fan (’Oceanographic Data of the Monterey Deep Sea Fan’, 1st

Update of Aircraft Profile Data for the Integrated Noise Model Computer Program. Volume 1. Final Report

DTIC Science & Technology

1992-03-01

general aviation 53 Cop. Fleet 1985 BUSINESS JET 1i F turbojet & turbofan 55 Gates LEAR 25 CJ610-8 1 E,F 54 Gates LEAR 36 TFE731 -2 3 E,F...Cessna CI1 3 TFE731 -3-1005 3 * E,F 60 Mitsubishi MU300-10 J3I1D-4 3 E,F 58 Canadair CL600 ALFSO2L 3 E, 61 Canadair CL601 CF34-3A 3 E,F 62 Israel A/C ASIRA...1125 TFE731 -3A 3 EF S.. ... .. ... ... .. . .. ... .............. - - - - - - - - - - - - - - - --I.....- -- --- -- - - -------.-- -- - - -- - 4

Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sunita,S.; Zhenxing, H.; Swaathi, J.

2006-01-01

Pseudouridine synthases catalyze the isomerization of uridine to pseudouridine ({psi}) in rRNA and tRNA. The pseudouridine synthase RluF from Escherichia coli (E.C. 4.2.1.70) modifies U2604 in 23S rRNA, and belongs to a large family of pseudouridine synthases present in all kingdoms of life. Here we report the domain architecture and crystal structure of the catalytic domain of E. coli RluF at 2.6 Angstroms resolution. Limited proteolysis, mass spectrometry and N-terminal sequencing indicate that RluF has a distinct domain architecture, with the catalytic domain flanked at the N and C termini by additional domains connected to it by flexible linkers. Themore » structure of the catalytic domain of RluF is similar to those of RsuA and TruB. RluF is a member of the RsuA sequence family of {psi}-synthases, along with RluB and RluE. Structural comparison of RluF with its closest structural homologues, RsuA and TruB, suggests possible functional roles for the N-terminal and C-terminal domains of RluF.« less

Energetic Diagrams and Structural Properties of Monohaloacetylenes HC≡CX (X = F, Cl, Br).

PubMed

Khiri, D; Hochlaf, M; Chambaud, G

2016-08-04

Highly correlated electronic wave functions within the Multi Reference Configuration Interaction (MRCI) approach are used to study the stability and the formation processes of the monohaloacetylenes HCCX and monohalovinylidenes C2HX (X = F, Cl, Br) in their electronic ground state. These tetra-atomics can be formed through the reaction of triatomic fragments C2F, C2Cl, and C2Br with a hydrogen atom or of C2H with halogen atoms via barrierless reactions, whereas the reactions between the diatomics [C2 + HX] need to overcome barriers of 1.70, 0.89, and 0.58 eV for X = F, Cl, and Br. It is found that the linear HCCX isomers, in singlet symmetry, are more stable than the singlet C2HX iso-forms by 1.995, 2.083, and 1.958 eV for X = F, Cl, and Br. The very small isomerization barriers from iso to linear forms are calculated 0.067, 0.044, and 0.100 eV for F, Cl, and Br systems. The dissociation energies of the HCCX systems (without ZPE corrections), resulting from the breaking of the CX bond, are calculated to be 5.647, 4.691, and 4.129 eV for X = F, Cl, Br, respectively. At the equilibrium geometry of the X(1)Σ(+) state of HCCX, the vertical excitation energies in singlet and triplet symmetries are all larger than the respective dissociation energies. Stable excited states are found only as (3)A', (3)A″, and (1)A″ monohalovinylidene structures.

Electrically Tunable g Factors in Quantum Dot Molecular Spin States

DTIC Science & Technology

2006-11-10

Electrically Tunable g Factors in Quantum Dot Molecular Spin States M. F. Doty,1,* M. Scheibner,1 I. V. Ponomarev,1 E. A. Stinaff,1 A. S . Bracker,1 V...L. Korenev ,2 T. L. Reinecke,1 and D. Gammon1 1Naval Research Laboratory, Washington, D.C. 20375, USA 2A.F. Ioffe Physical Technical Institute, St...on the applied electric field (F). PRL 97, 197202 (2006) P H Y S I C A L R E V I E W L E T T E R S week ending 10 NOVEMBER 2006 0031-9007=06=97(19

Thalmann Algorithm Decompression Table Generation Software Design Document

DTIC Science & Technology

2010-09-01

Undersea and Hyperbaric Medical Society for seawater at 4ºC.12 With this latter unrounded value...LA S TO P/ D IN C ) M IR E F = M (IR EF ,ID X ) R G I = (M IR EF – (P IN F+ 1. 0) )/N G R U M O D E ≥ 2 30 0 Y E S Le tte r g ro up : P R E F...Kensington, MD: Undersea and Hyperbaric Medical Society, 2002), pp. 118–136. 13. H. D. Van Liew, “Pressure Conversion Table,” Undersea

RADHOT: A Radiation Hydrodynamics Code for Weapon Effects Calculation.

DTIC Science & Technology

1981-03-01

h4A ( :: [ l), t.110 )" *- 7470 -C - C... C LUMI1LTI A F ’ :: ISUfI ----- --------------- 7480= P2 GM I ’: ;,,l. II 7490C:, A ......... ’ R..E I:I ’ S...AD-AlO 637 AIR FORCE INST OF TECH WRIGHTPATTERSON AFL O SCHOOETC F /8 12/ RADHOT: A RADIATION HYDRODYNAMICS CODE FOR WEAPON EFFECTS CALCU--ETC(U...change of internal energy due to radiation atj rad F monochromatic flux V F -, F inward and outward-going monochromatic fluxes at Va cell boundary F -, F1

Mechanism and influencing factors on critical pulse width of oil-immersed polymer insulators under short pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Liang, E-mail: zhaoliang@ninit.ac.cn; Li, Rui; Zheng, Lei

2015-04-15

The critical pulse width (τ{sub c}) is a pulse width at which the surface flashover threshold (E{sub f}) is equal to the bulk breakdown threshold (E{sub BD}) for liquid-polymer composite insulation systems, which is discovered by Zhao et al. [Annual Report Conference on Electrical Insulation and Dielectric Phenomena (IEEE Dielectrics and Electrical Insulation Society, Shenzhen, China, 2013), Vol. 2, pp. 854–857]. In this paper, the mechanism of τ{sub c} is interpreted in perspective of the threshold and the time delay (t{sub d}) of surface flashover and bulk breakdown, respectively. It is found that two changes appear as the pulse widthmore » decreases which are responsible for the existence of τ{sub c}: (1) E{sub BD} is lower than E{sub f}; (2) t{sub d} of bulk breakdown is shorter than t{sub d} of surface flashover. In addition, factors which have influences on τ{sub c} are investigated, such as the dielectric type, the insulation length, the dielectric thickness, the dielectrics configuration, the pulse number, and the liquid purity. These influences of factors are generalized as three types if τ{sub c} is expected to increase: (1) factors causing E{sub BD} to decrease, such as increasing the pulse number or employing a dielectric of lower E{sub BD}; (2) factors causing E{sub f} to increase, such as complicating the insulator's configuration or increasing the liquid purity; (3) factors causing E{sub BD} and E{sub f} to increase together, but E{sub f} increases faster than E{sub BD}, such as decreasing the dielectric thickness or the insulation length. With the data in references, all the three cases are verified experimentally. In the end, a general method based on τ{sub c} for solid insulation design is presented and the significance of τ{sub c} on solid insulation design and on solid demolition are discussed.« less

Proposed Revisions to MIL-F-8785C Related to Flight Safety of Augmented Aircraft. Volume 2. Appendices A through F, References

DTIC Science & Technology

1982-04-01

for Step 6h Command - Configuration FO, Fl, F6 , F4, F2 .................................................. ....... 309 C-15 Frequency Response of e/Fs...Configuration FO, Fl, F6 , F4, F2.. 312 C-16 Time History for Step Sh Command - Configuration L21, L71, L72, L73...505 T= 2 sec 2 F4 .465 4 sec F6 .453 6 sEc where F indicates unaugmented F-1l1A and the number following F indicates T2 in sec, except 0 : stable, 1

An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply

DTIC Science & Technology

2007-05-01

Marcantonio , Ph.D. Research Associate Dorothy...SB *pɘ.05 0 2 0 4 0 6 0 8 0 5 :1 1 0 :1 20 :1 E:T Ratio % S p e c i f i c L y s i s 100 101 102 103 104 FL2-Height Human Endoglin C o u n t s A B...Fig3. Cytotoxicity assay of breast cancer specific CTL. 0 5000 10000 15000 F l u o r e s c e i n l e v e l s / g HuEGEmpty Vector SB * *pɘ.005 B

Technology Insertion (TI)/Industrial Process Improvement (IPI). Task Order no. 1 (Misc Manufacturing). Book 1. Database Documentation Book for OO-ALC MANPWW (Overview Layouts)

DTIC Science & Technology

1989-12-15

0cQa 0 0 c 3oc 0040 - a ’A 9 . 1.. 1. Xew ft Mft OW so P% ^ t W%ft44 #4 A5 fW 0UA4N PA5 pml p" vq PI 0% P, PS t~00aa cacao 0 0310 a a 0 aC a a a 0 cc...e POVW4 /7. 411A4FI(I M6IC 6f w A24p az of CeIMS! &F /We/~ TO M&,f S/RZ-J /’ 1.1. NAZIS 7e P6’s’I r#e L ,?CZ-A%’ de Z.eCf 1S 4/ DO AV07R/AA~flS1~ dE ...aT Des siD F/m r IT /al was £141 Z AIII:. ?DEV UUOVCl ME? 74D OW 3PERVOCrA? $ Adz 7rNS7L OFF/CE Z~t ict,. A cAW IeAO of*’ wMM j#ft’ff NIrAZr Mra X4FF

Military Standard Generators Prototype Modifications. Volume 2. 30 kW DoD Generator Set

DTIC Science & Technology

1988-03-31

GE14 SET S,./14 KZO 5EJ41 70 KM,,*68 ý0 GEN S¢ET SIRN tɘ 5841 C 1 EXHAUST ± 484.71 DEG. F C I EXHAUST ± 545. 67 DEG. F C 2 EXHAUST 2 473.2-9 DEG. F...584t ý󈧣 Kid.- N Z GE14 SET SoN K20 584 ±i EXHAUST ± 85.64 bEG. F C. EXHAUST 1 062.12 DEG. F C 2 EXHAUSIT 2 75854 PEG.F C 2 EXHAUST 2 7M2± DEG. F c 7...E: 2ŗ GE14 . UVLT. P.RG. 78. 165 DEIG. F AL". C 23 GEN. UDLT. RIG. 69..945 DEG. F AL? C: 24 r:D[4TROL PANEL 68S.7 35% DEG. F ALM! C 24 CO4TRTOL PANEL

It’s Your Career - Get Involved and Give It all You Got,

DTIC Science & Technology

1985-04-01

SSS) the z-, 1 1 e,es of FtiE. s- ... t+ P23. c’-aCJ. s ,-u f, r - arc t- rt .I th sI.r I ar r, th,- -ds F ac’rri 1 -shmen t . Ser or Is-Ts s. r...Fcrn’ "I F- f 7r , I nll :j H-r-ni In ’ 1 Pci Ia leq- pc +’ N-’’i rl + rfre Z, aca r Plec ,eP P’,,.al s r-sr c ,zr C,-. l qe ,-, P-ir I -’rn a._r ,-sj-aF...who enters his/her current base three times. That’s where the officer is’ Checking the box "Desire to remain at current station" will let the

Receptor Structure for F1C Fimbriae of Uropathogenic Escherichia coli

PubMed Central

Khan, A. Salam; Kniep, Bernhard; Oelschlaeger, Tobias A.; Van Die, Irma; Korhonen, Timo; Hacker, Jörg

2000-01-01

F1C fimbriae are correlated with uropathogenic Escherichia coli strains. Although F1C fimbriae mediate binding to kidney tubular cells, their receptor is not known. In this paper, we demonstrate for the first time specific carbohydrate residues as receptor structure for F1C-fimbria-expressing E. coli. The binding of the F1C fimbriated recombinant E. coli strain HB101(pPIL110-54) and purified F1C fimbriae to reference glycolipids of different carbohydrate compositions was evaluated by using thin-layer chromatography (TLC) overlay and solid-phase binding assays. TLC fimbrial overlay analysis revealed the binding ability of purified F1C fimbriae only to glucosylceramide (GlcCer), β1-linked galactosylceramide 2 (GalCer2) with nonhydroxy fatty acids, lactosylceramide, globotriaosylceramide, paragloboside (nLc4Cer), lactotriaosylceramide, gangliotriaosylceramide (asialo-GM2 [GgO3Cer]) and gangliotetraosylceramide (asialo-GM1 [GgO4Cer]). The binding of purified F1C fimbriae as well as F1C fimbriated recombinant E. coli strain HB101(pPIL110-54) was optimal to microtiter plates coated with asialo-GM2 (GgO3Cer). The bacterial interaction with asialo-GM1 (GgO4Cer) and asialo-GM2 (GgO3Cer) was strongly inhibited only by disaccharide GalNAcβ1-4Galβ linked to bovine serum albumin. We observed no binding to globotetraosylceramide or Forssman antigen (Gb5Cer) glycosphingolipids or to sialic-acid-containing gangliosides. It was demonstrated that the presence of a GalCer or GlcCer residue alone is not sufficient for optimal binding, and additional carbohydrate residues are required for high-affinity adherence. Indeed, the binding efficiency of F1C fimbriated recombinant bacteria increased by 19-fold when disaccharide sequence GalNAcβ1-4Galβ is linked to glucosylceramide as in asialo-GM2 (GgO3Cer). Thus, it is suggested that the disaccharide sequence GalNAcβ1-4Galβ of asialo-GM2 (GgO3Cer) which is positioned internally in asialo-GM1 (GgO4Cer) is the high-affinity binding epitope for the F1C fimbriae of uropathogenic E. coli. PMID:10816509

State Space Methods in Multidimensional Digital Signal Processing

DTIC Science & Technology

1991-01-01

2-D finite difference equation with quarter-plane support is given by [1]. Li L-2 Ll L2 g (nln2) =E E Zb(jl,j2)f(n,-j, n 2 -j 2 ) - E a(jl,j2) g (n, - j...B2 [ g (n , n2)] = [C1 C2 1 Sq’(n nl2) ]+ D [f (ni, n 2 )] (2.2) Roesser’s state space model is based upon assigning state variables to the output of...QH(n - 1,n2) + [ B1 [f(nl,n2)]Qv(ni, n2) I A3 A411 Qv(nl, n2 -1 1 B2 [ g (n 1 ,n 2 )] = [C1 C 2] Q(n - n) + D[f(nin 2 )] (2.5) I Qv(ni,n2- 1) 1 In this

The First Class Questionnaire, Class of 1981

DTIC Science & Technology

1981-06-01

Classroom instruction 16.8 13.4 16.9 E. Cadet coaches 6.3 7.2 7.2 F. Other: __18.8 13.4 13.9 20. In my opinion, for me to improve my writing skills aL West...D. Other Ladets 16.9 17.8 16.0 E. My Company Tactical Officer 0.5 0.9 0 F. Other Staff & Faculty members such as instructors, sponsors, coaches 14.4...important -6 6& B. Major importance f3 C- I-Portant -71i5 .. Mie importance 14 E. importance 39 F Not applicable l.i- 716 (53C). Cadet Leadership Training

Computer Programs for Calculating Partially Cavitating Blunt Trailing Edged Cascade Flows in Nonlinear Theory.

DTIC Science & Technology

1980-01-01

I may $Vs ssauS@.. UNCLASSIFIED ’-X SINPIT CL6*41P-41 Iam Op THIS IAGr (Whom DAmOKo" UNCLASSIFIED -. j=U C%.A * CATO OIP I Thsa ,aOCett Di e Eee , 20...necessary only 6E13.6 if IFLAG = 1; SXSI(I), I =-1,6 correspond to b, c, f, A, a2 , and E . Values for SXSI(I) must be arbitrarily assumed and tried to...length ( = zc in Figure 1). 28 SXSI(I),I= 1,7 This card is necessary only 7F10.7 if IFLAG = 1; SXSI(I), I = 1, 7 correspond to b, c, f, A, o2’ a, and E . 0

DOE Research and Development Accomplishments Site Index (A-Z)

Science.gov Websites

dropdown arrow Site Map A-Z Index Menu Synopsis A - Z Index A B C D E F G H I J K L M N O P Q R S T U V W X Buckminsterfullerene Curl Smalley Buckyball Curl Smalley TOP A B C D E F G H I J K L M N O P Q R S T U V W X Y Z C transcription Dresselhaus, Mildred (Millie) Drosophila dynamics TOP A B C D E F G H I J K L M N O P Q R S T U V

East Coast Air Combat Maneuvering Range (EC/ACMR) Ocean Tower Construction Completion Report.

DTIC Science & Technology

1978-03-01

c)D Sa con itionS.r n lectricaldes St rm oactlvtto ~Utost 311fa :... ea rjn d~ ,Rjon,&gj B. ADMIN a m . cu a C. OPERATIONS: O;erations at Tower F3 ...nections. D. EQUIP STATUS - NONE E. LOGISTICS - NONE F. TRAINING NONE C. SAFETY - NO ACCIDENTS H. t,.EDICAL- NO INJURIES 1. ,ORALE- Nigh ad Tower f3 ...74. .-- Y .~lile B-. driven 59 ftv/5 6 0, 060, and 040 haieers; AV B,"F - e driven 57 ft w/5 6 0 and 040 hammers; AV BPP 82 v/540. Total weather time

Programma Conoscenza: Psycho-Educational, Integrated and Evolved Treatment for Cocaine Addiction

ERIC Educational Resources Information Center

Leonardi, Andrea; Fioravanti, Paolo; Scavelli, Sonia; Velicogna, Francesco

2009-01-01

The 2005 EMCDDA (European Monitoring Centre for Drugs and Drug Addiction, Annual report 2005: the state of the drugs problem in Europe, from http://ar2005.emcdda.europa.eu/en/home-en.html?CFID=5556438&CFTOKEN=9393b63b806e64c7-FB015A79-E157-F9DE-99626FADD9F4C983&jsessionid=2e30185a01447c413a1e) annual report remarks the dearth of options…

On P2 ⋄ Pn -supermagic labeling of edge corona product of cycle and path graph

NASA Astrophysics Data System (ADS)

Yulianto, R.; Martini, Titin S.

2018-04-01

A simple graph G = (V, E) admits a H-covering, where H is subgraph of G, if every edge in E belongs to a subgraph of G isomorphic to H. Graph G is H-magic if there is a total labeling f:V(G)\\cup E(G)\\to 1,2,\\ldots,|V(G)|+|E(G)|, such that each subgraph {H}{\\prime }=({V}{\\prime },{E}{\\prime }) of G isomorphic to H and satisfying f{({H}{\\prime })}=def{\\sum }\\upsilon \\in {V{\\prime }}f(\\upsilon )+{\\sum }e\\in {E{\\prime }}f(e)=m(f) where m(f) is a constant magic sum. Additionaly, G admits H-supermagic if f(V)=1,2,\\ldots,|V|. The edge corona {C}n \\diamond {P}n of Cn and Pn is defined as the graph obtained by taking one copy of Cn and n copies of Pn , and then joining two end-vertices of the i-th edge of Cn to every vertex in the i-th copy of Pn . This research aim is to find H-supermagic covering on an edge corona product of cycle and path graph {C}n \\diamond {P}n where H is {P}2 \\diamond {P}n. We use k-balanced multiset to solve our reserarch. Here, we find that an edge corona product of cycle and path graph {C}n \\diamond {P}n is {P}2 \\diamond {P}n supermagic for n > 3.

HESCOMP. The Helicopter Sizing and Performance Computer Program. User’s Manual. Revision 2.

DTIC Science & Technology

1979-10-01

uruieGlwChr)Pr f7 GO TO4100 ja I IDS CXS!G-CXS!GL* (1 CXS!G;I.CXS!G ~~~~ IF.X.T I X. NE. 0) jrWRTEi6.q90u IF XOL2MT(I)- CXS!G/CTPSL XCT2ILq II CTPSL 660...1 AO F ( F7 ~ ~ ~ 1 -I-3weN C3 77 C e0uffM~m1~asa~Y ~ rC -13 cS., 1 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ G 7CI4I*11t~~l~ I TI.V’,ITt- Figure 4-62. PARA Function, Flow...7-255 L C4SA. a ACA ANA ACCA I r- I r4. .m Q. . 7.f kJim p41 oml Ni Nii ’e N~6 a. aQa OL a -0 c .. -7 4.;- C~ 4c>.Q a,1 ci ~ ~ % a cam p- F. . a a a

Theory of Guided Acoustic Waves in Piezoelectric Solids.

DTIC Science & Technology

1979-07-01

would not be possible without Mike. I thank Laura Ruggieri for her patient and skillful typing of the manuscript. I would also like to thank Susan...anisotropic onizoeectr4c. solids [ 2 j. The b undary conditions are incorporated into rhe acoustic field equations using position -dependent material...x 2 ) = F " (:7) (2.3a) 2 L 7 where F denotes any of the material constants p, C, e or E of the sub- strate. F is its position -dependent value, e(x2

Investigation of Fire-Vulnerability-Reduction Effectiveness of Fire-Resistant Diesel Fuel in Armored Vehicular Fuel Tanks

DTIC Science & Technology

1980-09-30

Aberdeen Proving Ground, Maryland, September 1976. 2. Weatherford, W.D., Jr., Fodor, G.E., Naegeli , D.W., Owens, E.C., Wright, B.R., and Schaekel, F.W...Weatherford, W.I)., Jr., Fodor, G.E., Naegeli , D.W., Owens, E.C., Wright, B.R., and Schaekel, F.W., "Development of Army Fire-Resistant Diesel Fuel," Interim

United States Air Force Health Care Provider Practices: Skin Testing for Mycobacterium Tuberculosis

DTIC Science & Technology

1997-04-03

first, with 16 possible correct answers, was calculated using the formula: Total score = a + b + c + d + e + f +g + h + i + j-i-k + l + m + n + o + p...In The Literature 32 F . Gaps In Knowledge 34 Xlll CHAPTER THREE: METHODOLOGY A . Introduction 36 B. Research Design and Procedures 36 C . Research...The second, with 10 possible correct responses, was calculated using the formula: Total score = a + b + c + d + e + f +g + h + i+ j . The reasons for

Observation of Thermal Electron Detachment from Cyclo-C4F8 in FALP experiments

DTIC Science & Technology

1994-01-01

Maxwell- Boltzmann distri- electron affinity of C6 F6 was thought to be in bution of internal energy among the cyclo- the neighborhood of 1 eV, but...is not known but may be unimolecular rate for thermal electron detach- estimated as 0.63 eV from the results of the ment from C 6 F6 in the...delivery via SAL (Surface Air Lift) mail is ensured: Argentina, Australia, Brazil, Canada, Horg Kong, India, Israel, Japan, Malaysia , Mexico, New

19 CFR 356.8 - Continued suspension of liquidation.

Code of Federal Regulations, 2010 CFR

2010-04-01

...), (E), (F), or (G) of the Act (19 U.S.C. 1677(9)(C), (D), (E), (F) and (G)), may request continued... review that was a party to the proceeding, as described in section 771(9)(A) of the Act (19 U.S.C. 1677(9... Act (19 U.S.C. 1516a(a)(2)(B)(iii) and (vi)) and involving free trade area country merchandise, the...

19 CFR 356.8 - Continued suspension of liquidation.

Code of Federal Regulations, 2014 CFR

2014-04-01

...), (E), (F), or (G) of the Act (19 U.S.C. 1677(9)(C), (D), (E), (F) and (G)), may request continued... review that was a party to the proceeding, as described in section 771(9)(A) of the Act (19 U.S.C. 1677(9... Act (19 U.S.C. 1516a(a)(2)(B)(iii) and (vi)) and involving free trade area country merchandise, the...

19 CFR 356.8 - Continued suspension of liquidation.

Code of Federal Regulations, 2011 CFR

2011-04-01

...), (E), (F), or (G) of the Act (19 U.S.C. 1677(9)(C), (D), (E), (F) and (G)), may request continued... review that was a party to the proceeding, as described in section 771(9)(A) of the Act (19 U.S.C. 1677(9... Act (19 U.S.C. 1516a(a)(2)(B)(iii) and (vi)) and involving free trade area country merchandise, the...

Measuring Nigrescence Attitudes in School-Aged Adolescents

ERIC Educational Resources Information Center

Gardner-Kitt, Donna L.; Worrell, Frank C.

2007-01-01

In this study, we examined the reliability and validity of Cross Racial Identity Scale (CRIS; Vandiver, B. J., Cross Jr., W. E., Fhagen-Smith, P. E., Worrell, F. C., Swim, J. K., & Caldwell, L. D. (2000). "The Cross Racial Identity Scale." Unpublished scale; Worrell, F. C., Vandiver, B. J., & Cross Jr., W. E., (2004). "The Cross Racial Identity…

Air Force Office of Scientific Research Technical Report Summaries: October - December 1990

DTIC Science & Technology

1990-12-01

0 LOU L.4-OC) -C @ LO -cc 0t 00rz @ < w4 MO0). LI £41- a.) @ CCw ULf f> <. 03 :-3 f3 - - -I CU -- (c IL (P C a 0- . 4~-C i0L C w PA 0.V a)V 3T a - 0 0...u40) u 0 4, th-- E Uw)Z IX 0 CL W L E tw>-’I> C - u Li L (U Q)0 (0 00. L W C Z h 0 Z - 4-+ - .n W 0)Cf04 V 4- ) C <ZOZ 0 I 4- L u’,’m W 3-- ACCa )- >4...0).---0cC) E ZZ- 3 0- C -’ a) 0--)4- C4 W 0> f3 L ML >,U - O0in 3: CID Lu L r C L. (ALiIA 4- w oWM--- U Mw I X I- >- 11 Z M U LA- u a) m mm a)4) cii

Radome Boresight Error Assessment and Systems Evaluation Test Chamber Improvements.

DTIC Science & Technology

1983-04-01

OFFICIAL DEPARTMENT OF THE ARMY POSITION UNLESS SO DESIG- NATED BY OTHER AUTHORIZED DOCUMENTS. TRADE NAMES USE OF TRADE NAMES OR MANUFACTURERS IN THIS REPORT...SUFFE RAEC~I A:AHGtil E" 7WT1- ELI1: *LCPT I 61 INt F: EtF OFRZA ILITH E1C1 FANGLE ANGLEo ELAN:l E,-’ u TtlFE -+1’) *LOCRTION IN F’:-:E:U.F OFR

Final Report on Contract F49620-85-C-0026. Volume 1.

DTIC Science & Technology

1987-05-01

RFOSR-TR-S?-1349-VOL-1 UNCLMSSIFIED F40-BS-C46F/ 20/4 L E.EEEEEEEEE.E. 0 0 ’El..... oso - ~L.0 3 111IL25 . MJCROC(OP RESOLUTION TEST CHARI WiloUiAl SURIAU...Yakhot, R. Panda , U. Frisch, and R.H. Kraichnan, Weak Interactions and Local Order in Strong Turbulence, Phys. Rev. Let. (1986) submitted. -3- V. Yakhot

Jahn-Teller effect on the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) clusters embedded into SrF 2 crystals

NASA Astrophysics Data System (ADS)

Ulanov, V. A.; Zhiteitcev, E. R.; Varlamov, A. G.

2007-07-01

By means of EPR method the associative [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers were revealed in the fluorite type SrF 2:Ti and SrF 2:Ni crystals grown by Bridgman method in helium atmosphere containing some amount of a fluorine gas. It was found that at low temperatures the local structures of these associative centers were exposed to a static rhombic distortion. The reasons of such distortions were accounted for by the assumption that the E ⊗ ( b1 + b2) vibronic interaction became effective due to that the ground orbital states of the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers occurred to be doubly degenerated.

Evaluating the Effectiveness of Air Force Foundational Cyberspace Training

DTIC Science & Technology

2012-06-14

fileticket=zAcDCP6H2T4%3d&tabid=56&mid=415 (accessed 25 May 2012). VIT .1 Vita . U N I T E D S T A T E S A I R F O R C E MAJOR APRIL...as of May 2012) VIT .2 . U N I T E D S T A T E S A I R F O R C E MAJOR APRIL L. WIMMER ASSIGNMENTS 1. September 2000

F-16 Pilot Media Selection

DTIC Science & Technology

1981-03-01

sweep wLS1vaTI GrJAVA-M*- .~--- ’- - - -t------ 7EOA FFM 𔃼t ee.W?mv ~.L: 1.7.5.4/2n C.AMM~AT!: L’sftle MIMI I-- itlm . z4 ~~~as~e;.~~ i c’.1~te1...ac~e I C-s.met~ I £’A.F- ivsa ~ta I ~ acca az~Y I I tc~ ~t I tca± - e~aec N .x-c, ; cnar. ~ ;zar~a I ~i~; EC~I~ a c2r..1C:%ttI I ~t7!fl - -- rr..r

Process Characterization of Electrical Discharge Machining of Highly Doped Silicon

DTIC Science & Technology

2012-06-01

EEE .! E# EEE @! E#EEEI! E#EEEJ! E# EE "! E# EE ".! E# EE "@! E# EE "I! E# EE "J! $L! $U! 07$(L<--B(L$B(F-O(D1$(ZL]\\(E[( GMU! GML! 64... EE ! LFE# EE ! L@F# EE ! L@E# EE ! L<F# EE ! L<E# EE ! L.F# EE ! &*6)! M! NDO! D! %A! DP! N5P! /G! G! LY > (Z B ; [( G&’=41416(D1ɟ$(H&%&C-$-%( IEFG(N.76=416(LY...roughing experiment. Surface roughness measurements ranged from just over 24

BIA AND DOD SCHOOLS: Student Achievement and Other Characteristics Often Differ from Public Schools

DTIC Science & Technology

2001-09-01

access GAO reports on the Internet, send an e - mail message with “info” in the body to: Info@www.gao.gov or visit GAO’s World Wide Web home page at...may have more than one school. A F R I C A E U R O P E A T L A N T I C O C E A N Page 8 GAO-01-934 BIA and DOD Schools Figure 3: Locations of DOD...A S I A P A C I F I C O C E A N Page 9 GAO-01-934 BIA and DOD Schools Figure 4: Locations of DOD Domestic and Cuba Schools in School Year 1999–2000

Planning, Programming, and Budgeting System (PPBS)/Multi-year Programming: Reading Guide

DTIC Science & Technology

2010-09-01

51 B -4 Potter, Barry H ., and Jack Diamond. Guidelines for Public Expenditure...IS PA GE 1 9 b . TE LE P H ON E N U M B E R ( I n c l u d e A r e a C o d e ) U U U ...I N S T I T U T E F O R D E F E N S E A N A LY S E S IDA Document D-4057 Log: H 10-000982 September 2010 Planning, Programming, and Budgeting

Identification of surface-exposed domains on the reducing side of photosystem I

NASA Technical Reports Server (NTRS)

Xu, Q.; Guikema, J. A.; Chitnis, P. R.; Spooner, B. S. (Principal Investigator)

1994-01-01

Photosystem I (PSI) is a multisubunit enzyme that catalyzes the light-driven oxidation of plastocyanin or cytochrome c6 and the concomitant photoreduction of ferredoxin or flavodoxin. To identify the surface-exposed domains in PSI of the cyanobacterium Synechocystis sp. PCC 6803, we mapped the regions in PsaE, PsaD, and PsaF that are accessible to proteases and N-hydroxysuccinimidobiotin (NHS-biotin). Upon exposure of PSI complexes to a low concentration of endoproteinase glutamic acid (Glu)-C, PsaE was cleaved to 7.1- and 6.6-kD N-terminal fragments without significant cleavage of other subunits. Glu63 and Glu67, located near the C terminus of PsaE, were the most likely cleavage sites. At higher protease concentrations, the PsaE fragments were further cleaved and an N-terminal 9.8-kD PsaD fragment accumulated, demonstrating the accessibility of Glu residue(s) in the C-terminal domain of PsaD to the protease. Besides these major, primary cleavage products, several secondary cleavage sites on PsaD, PsaE, and PsaF were also identified. PsaF resisted proteolysis when PsaD and PsaE were intact. Glu88 and Glu124 of PsaF became susceptible to endoproteinase Glu-C upon extensive cleavage of PsaD and PsaE. Modification of PSI proteins with NHS-biotin and subsequent cleavage by endoproteinase Glu-C or thermolysin showed that the intact PsaE and PsaD, but not their major degradation products lacking C-terminal domains, were heavily biotinylated. Therefore, lysine-74 at the C terminus of PsaE was accessible for biotinylation. Similarly, lysine-107, or lysine-118, or both in PsaD could be modified by NHS-biotin.

Analysis of electronic parameters and frequency-dependent properties of Au/NiO/ n-GaN heterojunctions

NASA Astrophysics Data System (ADS)

Reddy, Varra Niteesh; Padma, R.; Gunasekhar, K. R.

2018-01-01

The electrical and frequency-dependent properties of ten Au/NiO/ n-GaN heterojunctions fabricated with similar conditions are assessed by I-V, C-V, and G-V measurement methods. In addition, C-f and G-f measurements are conducted in the frequency range of 1 kHz-1 MHz. The electronic parameters are changed from junction to junction even if they are fabricated in the similar way. The calculated barrier height and ideality factor values are fitted by the Gaussian distribution function. Statistical analysis of the data provides the mean barrier height and ideality factor values of 0.84 eV and 2.70 for the heterojunction. Besides, the mean barrier height ( V b), donor concentration ( N d), space charge layer width ( W D), and Fermi level ( E F) are determined from the C-V data and the corresponding values are 1.30 eV, 2.00 × 1017 cm-3, 8.222 × 10-6 cm, and 0.018 eV, respectively. The interface state density ( N SS) and relaxation time (τ) are assessed from C-f and G-f measurements. Moreover, the dielectric constant ( ɛ'), dielectric loss ( ɛ″), tangent loss (tan δ), and electrical conductivity ( σ ac) are determined from C-f and G-f data in the frequency range of 1 kHz-1 MHz with various biases (0.1-0.6 V). ɛ' and ɛ″ are decreased with increasing frequency.

Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

PubMed

Li, Wenji; Su, Zheng-Yuan; Guo, Yue; Zhang, Chengyue; Wu, Renyi; Gao, Linbo; Zheng, Xi; Du, Zhi-Yun; Zhang, Kun; Kong, Ah-Ng

2018-02-19

The carcinogenesis of prostate cancer (PCa) in TRAMP model is highly correlated with hypermethylation in the promoter region of Nrf2 and the accompanying reduced transcription of Nrf2 and its regulated detoxifying genes. We aimed to investigate the effects of (3E,5E)-3,5-bis-(3,4,5-trimethoxybenzylidene)-tetrahydro-thiopyran-4-one (F10) and (3E,5E)-3,5-bis-(3,4,5-trimethoxy-benzylidene)-tetrahydropyran-4-one (E10), two synthetic curcumin derivatives, on restoring Nrf2 activity in TRAMP C1 cells. HepG2-C8 cells transfected with an antioxidant-response element (ARE)-luciferase vector were treated with F10, E10, curcumin, and sulforaphane (SFN) to compare their effects on Nrf2-ARE pathways. We performed real-time quantitative PCR and Western blotting to investigate the effects of F10 and E10 on Nrf2, correlated phase II detoxification genes. We also measured expression and activity of DNMTand HDAC enzymes. Enrichment of H3K27me3 on the promoter region of Nrf2 was explored with a chromatin immunoprecipitation (ChIP) assay. Methylation of the CpG region in Nrf2 promoter was doubly examined by bisulfite genomic sequencing (BGS) and methylation DNA immunoprecipitation (MeDIP). Compared with curcumin and SFN, F10 is more potent in activating Nrf2-ARE pathways. Both F10 and E10 enhanced level of Nrf2 and the correlated phase II detoxifying genes. BGS and MeDIP assays indicated that F10 but not E10 hypomethylated the Nrf2 promoter. F10 also downregulated the protein level of DNMT1, DNMT3a, DNMT3b, HDAC1, HDAC4, and HDAC7 and the activity of DNMTs and HDACs. F10 but not E10 effectively reduced the accumulation of H3k27me3 on the promoter of Nrf2. F10 and E10 can activate the Nrf2-ARE pathway and increase the level of Nrf2 and correlated phase II detoxification genes. The reactivation effect on Nrf2 by F10 in TRAMP C1 may come from demethylation, decrease of HDACs, and inhibition of H3k27me3 accumulation.

Missile Facilities (WS-133B, WS-133A/M) Career Ladder, AFSCs 44530G, 44550G, and 44570G.

DTIC Science & Technology

1981-05-01

or more C1C)(,L)CT V )(,- 17. To vhat base are you assigned? Choose only one response. 1. Ellsworth AFB (Wing 2)E l -2. F. E. Warren AFB (Wing 5) 3...AD-A117 454 AIR FORC.E OCCUPATIONAL MEASUREMENT CENTER RANDOLPH AFB TX F/A 5/9MISILE FACILITIES MWS 1338. VS 133A/M) CAREER LADDER, AFSCS 44--ETCr~gn...OCCUPATIONAL MEASUREMENT CENTER S.,RANDOLPH AFB , TEXAS 78148 I_--- 82 07 06 255 PRIVACY ACT STATEMENT I c~c~c~ AUTHORITY: 5 Usc Sec 301, E09397, and AER 35-2

Synthesis, characterization and cytotoxic activity of substituted benzyl iminoether Pt(II) complexes of the type cis- and trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-R}2] (R=Me, OMe, F). X-ray structure of trans-[PtCl2{E-N(H)=C(OMe)CH2-C6H4-p-F}2].

PubMed

Mazzega Sbovata, Silvia; Bettio, Frazia; Marzano, Christine; Tassan, Augusto; Mozzon, Mirto; Bertani, Roberta; Benetollo, Franco; Michelin, Rino A

2008-04-01

New substituted benzyl iminoether derivatives of the type cis- and trans-[PtCl(2){E-N(H)C(OMe)CH(2)-C(6)H(4)-p-R}(2)] (R=Me (1a, 2a), OMe (3a, 4a), F (5a, 6a)) have been synthesized and characterized by elemental analyses, FT-IR spectroscopy and NMR techniques. The iminoether ligands are in the E configuration, which is stable in solution and in the solid state, as confirmed by the (1)H NMR data. Complex trans-[PtCl(2){E-N(H)C(OMe)CH(2)-C(6)H(4)-p-F}(2)] (6a) was also characterized by an X-ray diffraction study. Complexes 1a-6a have been tested against a panel of human tumor cell lines in order to evaluate their cytotoxic activity. cis-Isomers were significant more potent than the corresponding trans-isomers against all tumor cell lines tested; moreover, complexes 1a and 5a showed IC(50) values from about 2-fold to 6-fold lower than those exhibited by cisplatin, used as reference platinum anticancer drug.

Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds

PubMed Central

Makhanova, Natalia; Morgan, Andrew P.; Kayashima, Yukako; Makhanov, Andrei; Hiller, Sylvia; Zhilicheva, Svetlana; Xu, Longquan; Pardo-Manuel de Villena, Fernando; Maeda, Nobuyo

2017-01-01

Quantitative trait locus (QTL) analyses of intercross populations between widely used mouse inbred strains provide a powerful approach for uncovering genetic factors that influence susceptibility to atherosclerosis. Epistatic interactions are common in complex phenotypes and depend on genetic backgrounds. To dissect genetic architecture of atherosclerosis, we analyzed F2 progeny from a cross between apolipoprotein E-null mice on DBA/2J (DBA-apoE) and C57BL/6J (B6-apoE) genetic backgrounds and compared the results with those from two previous F2 crosses of apolipoprotein E-null mice on 129S6/SvEvTac (129-apoE) and DBA-apoE backgrounds, and B6-apoE and 129-apoE backgrounds. In these round-robin crosses, in which each parental strain was crossed with two others, large-effect QTLs are expected to be detectable at least in two crosses. On the other hand, observation of QTLs in one cross only may indicate epistasis and/or absence of statistical power. For atherosclerosis at the aortic arch, Aath4 on chromosome (Chr)2:66 cM follows the first pattern, with significant QTL peaks in (DBAx129)F2 and (B6xDBA)F2 mice but not in (B6x129)F2 mice. We conclude that genetic variants unique to DBA/2J at Aath4 confer susceptibility to atherosclerosis at the aortic arch. A similar pattern was observed for Aath5 on chr10:35 cM, verifying that the variants unique to DBA/2J at this locus protect against arch plaque development. However, multiple loci, including Aath1 (Chr1:49 cM), and Aath2 (Chr1:70 cM) follow the second type of pattern, showing significant peaks in only one of the three crosses (B6-apoE x 129-apoE). As for atherosclerosis at aortic root, the majority of QTLs, including Ath29 (Chr9:33 cM), Ath44 (Chr1:68 cM) and Ath45 (Chr2:83 cM), was also inconsistent, being significant in only one of the three crosses. Only the QTL on Chr7:37 cM was consistently suggestive in two of the three crosses. Thus QTL analysis of round-robin crosses revealed the genetic architecture of atherosclerosis. PMID:28837567

Composite Reliability Enhancement via Preloading.

DTIC Science & Technology

1987-06-01

LEAF’ 1150 FI’-,F "OATA REHD" 1160 E. EEF 11 0 RETUPN 2000 Id’’E 1- 4 2010 C LEAR ’? [C ’ "’ SAE C OPL I i t CE FILE" _i.’u D I ’-F’ 2020 DEP0,7’ KiP...CRFERTE N..H.26 41 AS.CIGN# I TO ’.t 41Th PRINT# I H; .E0,S.G1.K 4140 FOR I=1 TO N 415. ’ PPINT# I ; F’l I) D 1 4 1 i, NEXT I 4170 A’:’,SIGN# I TO .1 4150

Processings of Conference on Dynamics of Precision Gun Weapons (1st), held at Rock Island, Illinois, on January 26-27, 1977

DTIC Science & Technology

1977-02-18

Ji+ k’ W", 0 where T DIO 0 T 1tor _2 f \\ - + _3 Pz~ -dt - t f [2\\1O m+l/ ab + b Jb d and (26) T 3 (T z) i )F k j [2 (f 0i + x ~ A 1 Jd t ,., The terms...I 6b7 + A2 (0+)6 ( bjb 3 ) ItO )T Df + x AT 6b dt The end and jump conditions for A and A are 1 2 1 - A(tl 0 -) = 0 2 [Xi(tlO-) fi(tlO-)] = 0i=l...00 0 c’) 0 C’) 00 c’) 9: IAH HI ON co 0’ c a, - H 0 0 0 0 0H C1 H 0 0 000 0 Z F4 HH o 0 U C4 0 0 ’z AH H I U) -E- z 0 H ~P4 E-4 0 H H C4 C4 14 C4 C w

Canada’s First National Interoperability Baseline Assessment: CPRC 91052 Project Study

DTIC Science & Technology

2012-03-01

Time and Leadership. 33 Y on ge S t ., S ui te 4 20 , T or on to , O nt ar io C an ad a, M 5E 1 G 4 #91052 T A B L E O F C O N T E N T ...28  Essential Guidance 30   #91052 L I S T O F F I G U R E S P 1 Demographics...30 #91052 1 I N T H I S S T U D Y M e t h o d o l o g y This study was based on a web survey of 105

Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin.

PubMed

Sun, Xujuan; Wei, Bin; Liu, Shuqing; Guo, Chunmei; Wu, Na; Liu, Qinlong; Sun, Ming-Zhong

2016-12-01

Annexin A5 (Anxa5) is associated with the progression of some cancers, while its role and regulation mechanism in tumor lymphatic metastasis is rarely reported. This study aims to investigate the influence of Anxa5 knockdown on the malignant behaviours of murine hepatocarcinoma Hca-F cell line with high lymph node metastatic (LNM) potential and the underlying regulation mechanism. RNA interfering was performed to silence Anxa5 in Hca-F. Monoclonal shRNA-Anxa5- Hca-F cells were obtained via G418 screening by limited dilution method. Quantitative real-time RT-PCR (qRT-PCR) and Western blotting (WB) were applied to measure Anxa5 expression levels. CCK-8, Boyden transwell-chamber and in situ LN adhesion assays were performed to explore the effects of Anxa5 on the proliferation, migration, invasion and adhesion capacities of Hca-F. WB and qRT-PCR were used to detect the level changes of key molecules in corresponding signal pathways. We obtained two monoclonal shRNA-Anxa5-transfected Hca-F cell lines with stable knockdowns of Anxa5. Anxa5 knockdown resulted in significantly reduced proliferation, migration, invasion and in situ LN adhesion potentials of Hca-F in proportion to its knockdown extent. Anxa5 downregulation enhanced E-cadherin levels in Hca-F. Moreover, Anxa5 affected Hca-F behaviours specifically via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) instead of p38MAPK/c-Jun, Jnk/c-Jun and AKT/c-Jun pathways. Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells via ERK2/c-Jun/p-c-Jun(Ser73) and ERK2/E-cadherin pathways. It is an important molecule in metastasis (especially LNM) and a potential therapeutic target for hepatocarcinoma. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Resource Recovery Technology Application Document.

DTIC Science & Technology

1982-06-01

B-6 Electrostatic Precipitator (APC-C) ......................B-1O Venturi Scrubber (APC D) B-15 C Combustion Equipment (CE) C-1 Modular... Scrubber APC-D P. 1 of 4 CONTROLIII COMPONENT DESCRIPTION Types Available - Competing Components Type a. Venturi e. Moving bed Venturi b. Flooded disc f...Clean Gas to Demister (Used Separate Liquid from Gas Stream) / F C Scrubber Wall Liquid Inlet D Scrubber Liquid at Venturi Throat Inlet B E Venturi

A Comparison of Positive Outcome Expectancies: A Review of the Theories of M. F. Scheier, C. S. Carver, M. E. P. Seligman, and C. R. Snyder.

ERIC Educational Resources Information Center

Bird, William A.

Research has shown that optimistic and pessimistic outcome expectancy evaluations are associated with adaptive and maladaptive levels of psychological functioning, physical wellness, and health recovery issues. The research of M. F. Scheier, C. S. Carver, M. E. P. Seligman, and C. R. Snyder supports the hypothesis that elevated optimism or…

Remotely Manned Undersea Work Systems at Naval Ocean Systems Center (NOSC).

DTIC Science & Technology

1978-04-15

is applied to provide the most e t’t icient operations by best combining the coiupk-I mentar y characteristics of each of the subsystems. The tasks de ...i n de ’ s~ ~1 ~‘i s\\ s t e m s am cbo U o~% ~: SI •~R t I I ‘ to f ind lost it em s , locate wor k s i t C s , and sur\\ e\\ 5 e , t f l O t Ii , I...t l e i f l isis i t h i .i ‘se ’. l r c hl ‘.d l l i , i i , it will p m ism de ’ t a r ge ’t it le ’ i i t u f i ea — t i on , ,IS would a t e

Growth of YBCO Thin Films on TiN(001) and CeO2-Coated TiN Surfaces

DTIC Science & Technology

2012-02-01

Paranthaman, E.D. Specht , D.M. Kroeger, D.K. Christen, Q. He, B. Saffian, F.A. List, D.F. Lee, P.M. Martin, C.E. Klabunde, E. Hatfield, V.K. Sikka...Appl. Phys. Lett. 69 (1996) 1795. [4] M. Paranthaman, A. Goyal, F.A. List, E.D. Specht , D.F. Lee, P.M. Martin, Q. He, D.K. Christen, D.P. Norton, J.D

The Sixth Rochester Conference on Coherence and Quantum Optics

DTIC Science & Technology

1990-11-01

0CO~ EZE3:d5 : L4 .jLU 00 Oic C) - .E V c0) Z L Fr 0 0(C F)f C0L0E J0 0J a ==2 <U .- C ) c W CCyC C< CU)L Z) 2 C) 0 ~ ()A, 0 co .2 CL Cl 2 WW2 i oa...Instabilities and Chaos in infrared Gas Lasers with Saturable Absorber" P5 S.V. LAWANDE, Q.V. LAWANDE and B.N. JAGATAP (Bhabha Atomic Research Centre, Bombay

Microwave Acoustics Handbook. Volume 4. Bulk Wave Velocities-Numerical Data.

DTIC Science & Technology

1980-06-01

p .00 * a* *~ Ol r4 000a1 .C e e0 0 C ~ armC aeC PSFCU NU . FPS WF w N C ’O’ w N 0 0 It1 P SNF .4.64 *.4 F7 N P C L *- P U NF L 6 .184 * ff .UULUFUJ...1010 10 7.7.N𔃽f3.7.s 34.3.3.3.3 U5 IL I 4 0 * 0t * t ** * t ** *7 * * . A 7)..00a00UN03 . f7 ) UN7.030*4 30 .4 *000 4m 0 M 3.0 030a. w tr 300a, a,7M 7... acca :00 C0 0 0 w l . r C O r . C t. . C=c c t r a r a e C N .4 *0 NNONU’ C’ 0’C N 4* P 00£.4.40 N 40’ N NU . 4w C N ’ O . N 4 N C ’t C U lo. ’ U

10 CFR 51.101 - Limitations on actions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Limitations on actions. 51.101 Section 51.101 Energy... case of an application covered by §§ 30.32(f), 40.31(f), 50.10(c), 70.21(f), or §§ 72.16 and 72.34 of...(e), 50.10 (c) and (e), 70.23(a)(7) or § 72.40(b) of this chapter, as appropriate. (b) While work on...

75 FR 38603 - Qualification of Drivers; Exemption Renewals; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... James C. Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W...

49 CFR 173.52 - Classification codes and compatibility groups of explosives.

Code of Federal Regulations, 2012 CFR

2012-10-01

... or hypergolic liquid) E 1.1E1.2E 1.4E Article containing a secondary detonating explosive substance...-S 1.1 1.1A 1.1B 1.1C 1.1D 1.1E 1.1F 1.1G 1.1J 1.1L 9 1.2 1.2B 1.2C 1.2D 1.2E 1.2F 1.2G 1.2H 1.2J 1...

Gray AAF/Fort Lewis, Washington. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-12-14

each of more than 15,000 reporting stations around the world. This is the provenance of the number (e.g., HSC 999999) which will appear on future OL-A...CEILING VERSUS VISIBILITY2 .’ " ., ’LC.’ - -.SA\\H VERSUS A’ AAV /FT L5W S .f 73-! ’E GE F Q E N y OF $C’<,>1F - PO.’ -O’ L OBSER, ATON’ :j - . 2 .3 2...3ś o --:---- .. 609- - . . ; L. _ _ cL AL CLT’MAT’LOCY PRANCH L -- "TAC PSYCHROMETRIC SUMMARY A: TH7’ SERVICE/MA: 74- 7, . AAV AA /F T LEk!S kA

Application of LEED (trademark) and SPiRiT to a Proposed Building Design

DTIC Science & Technology

2003-03-01

TOTAL AREA S CAT ARLOC INSTALLATION NO CODE C QTY UM OCPD F CODE 1) 24004 Aberdeen Provi E1890...ARLOC INSTALLATION NO CODE C QTY UM OCPD F CODE 1) 24004 Aberdeen Provi E3832 31010 P 13,000 SF 13,000 R

DoD Components Did Not Properly Use the Acquisition and Cross Service Agreement Automated Tracking and Reporting System

DTIC Science & Technology

2016-03-24

field. For more information about whistleblower protection, please see the inside back cover. I N T E G R I T Y  E F F I C I E N C Y  A C C O U N T...Services OIG Office of Inspector General OIR Operation Inherent Resolve Whistleblower Protection U.S. Department of Defense The Whistleblower Protection...Enhancement Act of 2012 requires the Inspector General to designate a Whistleblower Protection Ombudsman to educate agency employees about prohibitions

An Analysis of Success in Systems Program Management.

DTIC Science & Technology

1981-02-27

D’Neill Lt en. Edmund F. O’Connor Lt :en. john B. Hudson I t. Cen. Robert T. Marsh ’t. ’-en. Rotert C . Mathis It. Cen. Z.eorge H. 2yivester...Snaveiy Lt. Gen. Harry E. Goldsworthy Lt. Gen. Robert C . Ruegg Lt. Gen. Thomas P. Gerrity OSD/DDR&E Dr. m.J. Perry Dr. M. Currie Dr. John Foster OSD/PA&E...UNCLASSIFIED NI*2 fflfflfllfllflfflfEEhEhEEE El/llEEEEEl/E- EEEEEE/I/I- mE....-.I/1 Report F33615-8 - C -5184.11 rmi AN ANALYSIS OF SUCCESS IN SYSTEMS

EnviroAtlas Estimated Percent Tree Cover Along Walkable Roads Web Service

EPA Pesticide Factsheets

This EnviroAtlas dataset estimates tree cover along walkable roads. The road width is estimated for each road and percent tree cover is calculated in a 8.5 meter strip beginning at the estimated road edge. Percent tree cover is calculated for each block between road intersections. Tree cover provides valuable benefits to neighborhood residents and walkers by providing shade, improved aesthetics, and outdoor gathering spaces. For specific information about each community's Estimated Percent Tree Cover Along Walkable Roads layer, consult their individual metadata records: Austin, TX (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B4876FD99-C14A-464A-9E31-5CB5F2225687%7D); Cleveland, OH (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B28e3f937-6f22-45c5-98cf-1707b0fc92df%7D); Des Moines, IA (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7B09FE7D60-B636-405C-BB07-68147DFE8CAF%7D); Durham, NC (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BF341A26B-4972-4C6B-B675-9B5E02F4F25F%7D); Fresno, CA (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BB71334B9-C53A-4674-A739-1031969E5163%7D); Green Bay, WI (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BB9AFEBED-9C29-4DB0-8B54-0CAF58BE5A2D%7D); Memphis, TN (https://edg.epa.gov/metadata/catalog/search/resource/details.page?uuid=%7BBE552E7A-A789-4AA9-ADF9-234109C6517E%7D); Mi

Taking Proof based Verified Computation a Few Steps Closer to Practicality (extended version)

DTIC Science & Technology

2012-06-27

general s2 + s, in general V’s per-instance CPU costs Issue commit queries (e + 2c) · n/β (e + 2c) · n/β Process commit responses d d Issue PCP...size (# of instances) (§2.3) e: cost of encrypting an element in F d : cost of decrypting an encrypted element f : cost of multiplying in F h: cost of...domain D (such as the integers, Z, or the rationals, Q) to equivalent constraints over a finite field, the programmer or compiler performs 3We suspect

Simplification to single-tablet regimen of elvitegravir, cobicistat, emtricitabine, tenofovir DF from multi-tablet ritonavir-boosted protease inhibitor plus coformulated emtricitabine and tenofovir DF regimens: week 96 results of STRATEGY-PI.

PubMed

Arribas, Jose R; DeJesus, Edwin; van Lunzen, Jan; Zurawski, Christine; Doroana, Manuela; Towner, William; Lazzarin, Adriano; Nelson, Mark; McColl, Damian; Andreatta, Kristen; Swamy, Raji; Szwarcberg, Javier; Nguyen, Thai

2017-05-01

Antiretroviral therapy (ART) simplification to a single-tablet regimen can benefit HIV-1-infected, virologically suppressed, individuals on ART composed of multiple pills. We assessed long-term efficacy and safety of switching to co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (E/C/F/TDF) from multi-tablet ritonavir-boosted protease inhibitor (PI + RTV) plus F/TDF (TVD) regimens. STRATEGY-PI was a 96-week, phase 3b, randomized (2:1), open-label, non-inferiority study examining the efficacy, safety, and tolerability of switching to E/C/F/TDF from PI + RTV + TVD regimens in virologically suppressed individuals (HIV-1 RNA <50 copies/mL). Participants were randomized to switch to E/C/F/TDF (switch group) or to continue their PI + RTV + TVD regimens (no-switch group). Eligibility criteria included no resistance to F/TDF or history of virologic failure, and estimated creatinine clearance ≥70 mL/min. At week 96, 87% (252/290) of switch and 70% (97/139) of no-switch participants maintained HIV-1 RNA <50 copies/mL (difference: 17%, 95% CI 8.7-26.0%, p < 0.001). Superiority of the switch to E/C/F/TDF vs. no-switch was due to a smaller proportion of both virologic failures (switch, 1% [3/290]; no-switch, 6% [8/139]) and discontinuations for non-virologic reasons (switch, 11% [31/290]; no-switch, 24% [33/139]). No treatment-emergent resistance was observed in switch subjects with virologic failure. Discontinuation rates from adverse events were 3% in both groups (9/293, switch; 4/140, no-switch). Switching from PI + RTV + TVD to E/C/F/TDF was associated with significant improvements in patient-reported outcomes related to gastrointestinal symptoms (nausea and bloating). E/C/F/TDF is a safe, effective long-term alternative to multi-tablet PI + RTV + TVD-based regimens in virologically suppressed, HIV-1-infected adults, and improves patient-reported gastrointestinal symptoms.

Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones.

PubMed

Simunovic, Vesna; Müller, Rolf

2007-07-23

It has been proposed that two acyl carrier proteins (ACPs)-TaB and TaE--and two 3-hydroxy-3-methylglutaryl synthases (HMGSs)--TaC and TaF--could constitute two functional ACP-HMGS pairs (TaB/TaC and TaE/TaF) responsible for the incorporation of acetate and propionate units into the myxovirescin A scaffold, leading to the formation of beta-methyl and beta-ethyl groups, respectively. It has been suggested that three more proteins--TaX and TaY, which are members of the superfamily of enoyl-CoA hydratases (ECHs), and a variant ketosynthase (KS) TaK--are shared between two ACP-HMGS pairs, to give the complete set of enzymes required to perform the beta-alkylations. The beta-methyl branch is presumably further hydroxylated (by TaH) and methylated to produce the methoxymethyl group observed in myxovirescin A. To substantiate this hypothesis, a series of gene-deletion mutants were created, and the effects of these mutations on myxovirescin production were examined. As predicted, DeltataB and DeltataE ACP mutants revealed similar phenotypes to their associated HMGS mutants DeltataC and DeltataF, respectively, thus providing direct evidence for the role of TaE/TaF in the formation of the beta-ethyl branch and implying a role for TaB/TaC in the formation of the beta-methyl group. Production of myxovirescin A was dramatically reduced in a DeltataK mutant and abolished in both the DeltataX and the DeltataY mutant backgrounds. Analysis of a DeltataH mutant confirmed the role of the cytochrome P450 TaH in hydroxylation of the beta-methyl group. Taken together, these experiments support a model in which the discrete ACPs TaB and TaE are compatible only with their associated HMGSs TaC and TaF, respectively, and function in a substrate-specific manner. Both TaB and TaC are essential for myxovirescin production, and the TaB/TaC pair can rescue antibiotic production in the absence of either TaE or TaF. Finally, the reduced level of myxovirescin production in the DeltataE mutant, relative to the DeltataF strain, suggests an additional function of the TaE ACP.

Accretion-powered Compact Binaries

NASA Astrophysics Data System (ADS)

Mauche, Christopher W.

2003-12-01

Preface; The workshop logo; A short history of the CV workshop F. A. Córdova; Part I. Observations: 1. Low mass x-ray binaries A. P. Cowley, P. C. Schmidtke, D. Crampton, J. B. Hutchings, C. A. Haswell, E. L. Robinson, K. D. Horne, H. M. Johnston, S. R. Kulkarni, S. Kitamoto, X. Han, R. M. Hjellming, R. M. Wagner, S. L. Morris, P. Hertz, A. N. Parmar, L. Stella, P. Giommi, P. J. Callanan, T. Naylor, P. A. Charles, C. D. Bailyn, J. N. Imamura, T. Steiman-Cameron, J. Kristian, J. Middleditch, L. Angelini and J. P. Noris; 2. Nonmagnetic cataclysmic variables R. S. Polidan, C. W. Mauche, R. A. Wade, R. H. Kaitchuck, E. M. Schlegel, P. A. Hantzios, R. C. Smith, J. H. Wood, F. Hessman, A. Fiedler, D. H. P. Jones, J. Casares, P. A. Charles, J. van Paradijs, E. Harlaftis, T. Naylor, G. Sonneborn, B. J. M. Hassall, K. Horne, C. A. la Dous, A. W. Shafter, N. A. Hawkins, D. A. H. Buckley, D. J. Sullivan, F. V. Hessman, V. S. Dhillon, T. R. Marsh, J. Singh, S. Seetha, F. Giovannelli, A. Bianchini, E. M. Sion, D. J. Mullan, H. L. Shipman, G. Machin, P. J. Callanan, S. B. Howell, P. Szkody, E. M. Schlegel and R. F. Webbink; 3. Magnetic cataclysmic variables C. Hellier, K. O. Mason, C. W. Mauche, G. S. Miller, J. C. Raymond, F. K. Lamb, J. Patterson, A. J. Norton, M. G. Watson, A. R. King, I. M. McHardy, H. Lehto, J. P. Osborne, E. L. Robinson, A. W. Shafter, S. Balachandran, S. R. Rosen, J. Krautter, W. Buchholz, D. A. H. Buckley, I. R. Tuoly, D. Crampton, B. Warner, R. M. Prestage, B. N. Ashoka, M. Mouchet, J. M. Bonnet-Bidaud, J. M. Hameury, P. Szkody, P. Garnavich, S. Howell, T. Kii, M. Cropper, K. Mason, J. Bailey, D. T. Wickramasinghe, L. Ferrario, K. Beuermann, A. D. Schwope, H.-C. Thomas, S. Jordan, J. Schachter, A. V. Filippenko, S. M. Kahn, F. B. S. Paerels, K. Mukai, M. L. Edgar, S. Larsson, R. F. Jameson, A. R. King, A. Silber, R. Remillard, H. Bradt, M. Ishida, T. Ohashi and G. D. Schmidt; Part II. Accretion Theory: 4. Nonmagnetic W. Kley, F. Geyer, H. Herold, H. Ruder, R. Whitehurst, A. King, J. C. Wheeler, S. Mineshige, M. Huang, S. W. Kim, Y. Tuchman, T. R. Kallman and J. A. Woods; 5. Magnetic M. T. Wolff, J. N. Imamura, K. S. Wood, J. H. Gardner, S. J. Litchfield, J. J. Brainerd, G. Chanmugan, K. Wu, J. Frank, T. Hanawa, K. Hirotani and N. Kawai; Part III. Novae S. Starrfield, R. M. Hjellming, A. B. Tomaney, A. W. Shafter, A. Cassatella, P. L. Selvelli, R. Gilmozzi, A. Bianchini, M. Friedjung, H. Ritter, M. J. Politano, M. Livio, R. F. Webbink, K. Horne, W. F. Welsh, R. A. Wade, J. Krauttler, M. A. J. Snijders, N. Vogt, L. H. Barrera, H. Barwig, K.-H Mantel, R. Gilmozzi, A. Shankar, A. Burkert, J. W. Truran and J. Hayes: Part IV. Evolution I. Iben Jr, M. S. Hjellming, R. E. Taam, M. Politano, F. D'Antona, I. Mazzitelli, H. Ritter, J. M. Hameury, A. R. King, J. P. Lasota, R. Popham, R. Narayan, J. Isern, J. Laybay, R. Canal, D. García, A. S. Fruchter, S. R. Kulkarni, R. W. Romani, A. Ray, W. Kluzniak, S. Miyaji and G. Chanmugam; Subject index; Star index.

Final Environmental Assessment for Proposed Airspace Changes for Paradise East and Paradise West Military Operations Areas (MOAs) at Mountain Home Air Force Base (MHAFB) Idaho

DTIC Science & Technology

2010-03-29

IR FO R C E\\ 32 99 91 AI R SP A C E EA \\G IS \\M X D \\F IG U R E- A LT ER N AT IV E A. M X D M KO U BE K...basis. BO I \\\\O W L\\ PR O J\\ M O U N TA IN H O M EA IR FO R C E\\ 32 99 91 AI R SP A C E EA \\G IS \\M X D \\F IG U R E- A LT ER N AT IV E B. M X D M KO...MTR. MTR segments are identified and charted as either IR routes (IFR) or VR routes

Exploring the Integration of COSYSMO with a Model-Based Systems Engineering Methodology in Early Trade Space Analytics and Decisions

DTIC Science & Technology

2016-06-01

UAV system but had a larger scope. The publishing timeline for the second UAV model and this thesis ...r l o g i c a l ) t h a t can be used t o d e s c r i b e a p a r t o f t h e model . < / d e s c r i p t i o n > 7 <h idden> f a l s e < / h idden...July). Program manager e -tool kit: Hierarchy of models and simulations . [Online]. Available: https://acc.dau.mil/CommunityBrowser.aspx?id= 294530

Severe Weather Guide - Mediterranean Ports. 2. Naples

DTIC Science & Technology

1988-01-01

Include Security Classification) S^ere Weather Guide - Mediterranean Ports - 2. Naples (U) ? SONAi <^UTHOR(S) .■/ L,^glebretson, Ronald E. (LCDR...AN ( j. ) HIJ-H F’B (2i 040200 ■ CI ’ 3) (U) C A (b) o I..; i E W C E A F’ P L. IC A T.[ G N Ei IN ! E R N...threatened try actual or -forecast 51 r D n q w i n d s , n i g n a e a s , r s s t r i c t e d v i s i D1111 y o i- thunderstcjrms m the port

The Effects of Hub Drag, Solidity, Dual Rotation, and Number of Blades upon the Efficiency of High-Pitch Propellers

DTIC Science & Technology

1941-10-01

obJectivos. Pr.w eiited i n t h ” s rcpoi-t are thc ? rc.,:iG.tn of thesc? experiments wh’ch i , c e cslri-ied ou t f o r t h e K.WA i n t n...r shroude slig"lt1y overlapped thc spinners, clc3rcd them radially b) 0.05 inch an< t e rn ina te3 2.2 inches a f t of the ;:.me of ro?a t ion...o adinit t;ie c i r c u l a r Slade shanks and the Si i t ts of t h e blades tovched thc spimiers when scc a t iargs a q l e s . (Sce f i g

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 85. Part 5 (Seaward Construction - Zytron Corporation).

DTIC Science & Technology

1985-01-01

4𔃺 00 1.C~ f6 Ln N a do00 0 wa n a L 00 43n 0) -ci e4 N1 C14 00 a ~. OD.4 , c I LL. z :i% -4- j i - 0) r -- - 0 I 0 0 00 N oc 0)) co 0)01 00 0 0 ~ J...0 1 1. F6 O. II -F- . I- I .- I I. .C. . . . . . . . . "A6%4 % UU- W4 w CL8 8:0 I 4 I Wt C V 08 I 8 I I e Cl dc m I ) I I Coc (D 0 C nI 4 ( a (4t 4...tLI 0 Z am a - o -4 I I,- - a4 C 0 C-4- acca a O-c 0)( C -. Na( an1 c . -.4 N. Nm ca ’. -. %--ca4-4 0 - a E I Ua an .0- 4 C r- Na C)G I-0C 0 0 0’ 0 ) 0

Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acids.

PubMed

Jackson, Kim G; Wolstencroft, Emma J; Bateman, Paul A; Yaqoob, Parveen; Williams, Christine M

2005-01-01

Although there is considerable interest in the postprandial events involved in the absorption of dietary fats and the subsequent metabolism of diet-derived triacylglycerol-rich lipoproteins, little is known about the effects of meal fatty acids on the composition of these particles. We examined the effect of meal fatty acids on the lipid and apolipoprotein contents of triacylglycerol-rich lipoproteins. Ten normolipidemic men received in random order a mixed meal containing 50 g of a mixture of palm oil and cocoa butter [rich in saturated fatty acids (SFAs)], safflower oil [n-6 polyunsaturated fatty acids (PUFAs)], or olive oil [monounsaturated fatty acids (MUFAs)] on 3 occasions. Fasting and postprandial apolipoproteins B-48, B-100, E, C-II, and C-III and lipids (triacylglycerol and cholesterol) were measured in plasma fractions with Svedberg flotation rates (S(f)) >400, S(f) 60-400, and S(f) 20-60. Calculation of the composition of the triacylglycerol-rich lipoproteins (expressed per mole of apolipoprotein B) showed notable differences in the lipid and apolipoprotein contents of the SFA-enriched particles in the S(f) > 400 and S(f) 60-400 fractions. After the SFA meal, triacylglycerol-rich lipoproteins in these fractions showed significantly greater amounts of triacylglycerol and of apolipoproteins C-II (S(f) 60-400 fraction only), C-III, and E than were found after the MUFA meal (P < 0.02) and more cholesterol, apolipoprotein C-III (S(f) > 400 fraction only), and apolipoprotein E than after the PUFA meal (P < 0.02). Differences in the composition of S(f) > 400 and S(f) 60-400 triacylglycerol-rich lipoproteins formed after saturated compared with unsaturated fatty acid-rich meals may explain differences in the metabolic handling of dietary fats.

31 CFR 315.32 - Series A, B, C, D, F, G, J, and K bonds.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Series A, B, C, D, F, G, J, and K.... SAVINGS BONDS, SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES Interest § 315.32 Series A, B, C, D, F, G, J, and K bonds. All bonds of these series have matured and no longer earn interest. ...

31 CFR 315.32 - Series A, B, C, D, F, G, J, and K bonds.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Series A, B, C, D, F, G, J, and K.... SAVINGS BONDS, SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES Interest § 315.32 Series A, B, C, D, F, G, J, and K bonds. All bonds of these series have matured and no longer earn interest. ...

31 CFR 315.32 - Series A, B, C, D, F, G, J, and K bonds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Series A, B, C, D, F, G, J, and K.... SAVINGS BONDS, SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES Interest § 315.32 Series A, B, C, D, F, G, J, and K bonds. All bonds of these series have matured and no longer earn interest. ...

Application of Future State Decision Making in the Eagle Combat Model

DTIC Science & Technology

1990-09-01

not reflect the official policy or position of the Department of Defense or the U.S. Government. 1 7 Cosati Codes 18 S:iDj,.ct Terms (continue on... cncd 30 40 co el C14N- LI)I E- . IC041 00 E E. C) CD 0 06. 4104 xd- .r - 1 w a S.CL U.~- 0 S.31 Cl- w cu N ~ ~ -.- - f Lin EEn LM 0f CCN. ’C4 0 4-it 0

U.S. EPA, Pesticide Product Label, PENNINGTON SEVIN BRAND CARBARYL INSECTICIDE GRANULES, 06/02/1992

EPA Pesticide Factsheets

2011-04-21

f¥Y' 19 .5 '{I 'I of - j() z",;,,JMl ~ - .: it F..~:I J- VLSL'Lii.~::> d_ (----eEED ~~ :rC"~~., f 'M .... DlUolA".® - 11. ~~~~ G-~:z cT •• L--F .... ~S ...

The Defense Logistics Agency Properly Awarded Power Purchase Agreements and the Army Obtained Fair Market Value for Leases Supporting Power Purchase Agreements

DTIC Science & Technology

2016-09-28

Fair Market Value for Leases Supporting Power Purchase Agreements I N T E G R I T Y  E F F I C I E N C Y  A C C O U N T A B I L I T Y  E X... Market Value for Leases Supporting Power Purchase Agreements Visit us at www.dodig.mil September 28, 2016 Objective We determined whether the...Department of the Army properly awarded and obtained fair market value for leases supporting energy production projects. We conducted this audit in

The Radar Cross Sections of Hayes TRX-11, TPT-5A and TPT-5l Towed Targets

DTIC Science & Technology

1992-08-01

Cl~~~~~ C C’ tV e mata a-- e- acCA C C, ’aC ’.’. - Caý C I ’. Cl CA w t Cl- - - -- - - - - - -- - ,C -r laCa - - - wC 7 A;’ Va -.- C- ae o 0’ -CC Cln...ATF (2 copies) SPARES (6 COPIES) TOTAL (47 COPIES) k: I. 11 DE-P~a•AK-6EN7 OF !)F’ý.A;CEt PAGE C ia•%•,S F1 ( A’I!O \\ UNACLASSIFIED.O DOCUMENT CONTROL

An Expert System Decision Aid for a Command, Control and Communications Operator.

DTIC Science & Technology

1985-12-01

34ET F.:E310N INJ) IF LN’ HLC T 2=.,69 LN’ HLaaOi’=1 L N ’-: H L I-T’ T THEN (TaETa RE’ION ’WES); rIF LNI- HLa .1 3 -, ~~L N L: H L C-1 N G3 > 19...HY’OTF:AN:.:FEF: ’ T) Ru n:Ur i:- ’[ - _ N R: E -]; 0-L YV ED ’ .’qT C-I P ). " I F B27 : B,:ar d E ’N1iIB [F: K.= 2 GETPROP E’ENTMT1TCH ’ P2CONFIDENC:E

Topics in Multivariate Approximation Theory.

DTIC Science & Technology

1982-05-01

once that a continuous function f can be approximated from Sa :o span (N3 )B63 to within *(f, 131 ), with 13 t- sup3 e3 dian PS The simple approximation...N(C) 3- U P s P3AC 0 0 ) . Then, as in Lebesgue’s inequality, we could conclude that f - Qf - f-p - Q(f-p) , for all p e k k therefore I(f-0f) JCI 4 I

Empirical Characterization of Unconstrained Tape Spring Deployment Dynamics

DTIC Science & Technology

2012-03-22

1 ) ∗ s (2 ) ∗c (3 ) , −s (1 ) ∗c (3 )+c (1 ) ∗ s (2 ) ∗ s (3 ) , c (1 ) ∗c (2 ) ; . . . ] ∗ ( data ’ ) ) ’ ; % o r i g i n a l f ormu la t ion : 1...data ’ ) ) ’ ; 756 % o r i g i n a l f ormu la t ion : 1−2−3 % the t a=ang l e s ; % gdata = ( ( [ 1 , 0 , 0 ; 0 , cos ( t h e t a (1) ) ,− s

The Solar Mass Ejection Imager (SMEI) Space Experiment

DTIC Science & Technology

2015-01-30

Price, S., Radick, R. R., Sagalyn, R., Sinclair, D., Simnett, G. M., Eyles, C. J ., Cooke, M. P., Tappin, S. J ., Kuchar, T ., Mizuno, D. R., Webb, D. F...207. [3] Kaiser, M. L., Kucera, T . A., Davila, J . M., St. Cyr, O. C., Guhathakurta, M., and Christian, E., “The STEREO Mission: An Introduction...D. F., Mizuno, D. R., Buffington, A., Cooke, M. P., Eyles, C. J ., Fry, C. D., Gentile, L. C., Hick, P. P., Holladay, P. E., Howard, T . A., Hewitt

Theoretical and Numerical Analysis for Non-Linear Interface Problems

DTIC Science & Technology

2007-04-19

Report 17 . LIMITATION OF ABSTRACT SAR 15. NUMBER OF PAGES 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 5c. PROGRAM ELEMENT NUMBER 5b...8217$94ZY.4,;X/,)@4P*<I $𔃽AC+4)@4&@C+&[CE*]\\_^ \\_`<ab#^c5J$’&+&+$’*.3%&d4&@(-421$e/’>f$𔃽gC+"% 4Ph =42097%&R*,I/,B8CE*.5J/<CE$𔃻 Ci/,)@:.42C )@41

Installation Restoration Program. Phase 2. Confirmation/Quantification Stage 1. US Air Force Plant Number 42, Palmdale, California. Volume 2.

DTIC Science & Technology

1987-02-20

Dnor:)c7i’,orotneane .0i fN D____ __I______ C,-icniorcetnyene 0.10 N:DO.02 ____ ____ ____ I n1 ic o cni e -i - ---ii 1- - - 1 Di c roreae_____...n -c 0a r~e~n’ 0.010 NDɘ.010 _____ --- H I().01-0 1z0 0 c ND 7*, 5 was nUJVC.. ceteize ; the _ _ limit__ of deec iofrhiaalsi i _____ ,a t- s-Ie...PASADENA CALIF 20 FEB 87 U N LASF IE F31615-84-D -448 2 F/G 24/7 M N1 . - 1111_1 % . .- 1511 1*% EncineerinQ Science Page 11 ANALYTICAL RESULTS SUMMARY

THE ROLE OF THE RETINOBLASTOMA/E2F1 TUMOR SUPPRESSOR PATHWAY IN THE LESION RECOGNITION STEP OF NUCLEOTIDE EXCISION REPAIR

PubMed Central

Lin, Patrick S.; McPherson, Lisa A.; Chen, Aubrey Y.; Sage, Julien; Ford, James M.

2009-01-01

The retinoblastoma Rb/E2F tumor suppressor pathway plays a major role in the regulation of mammalian cell cycle progression. The pRb protein, along with closely related proteins p107 and p130, exerts its anti-proliferative effects by binding to the E2F family of transcription factors known to regulate essential genes throughout the cell cycle. We sought to investigate the role of the Rb/E2F1 pathway in the lesion recognition step of nucleotide excision repair (NER) in mouse embryonic fibroblasts (MEFs). Rb−/−;p107−/−;p130−/− MEFs repaired both cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PPs) at higher efficiency than did wildtype cells following UV-C irradiation. The expression of damaged DNA binding gene DDB2 involved in the DNA lesion recognition step was elevated in the Rb family-deficient MEFs. To determine if the enhanced DNA repair in the absence of the Rb gene family is due to the derepression of E2F1, we assayed the ability of E2F1-deficient cells to repair damaged DNA and demonstrated that E2F1−/− MEFs are impaired for the removal of both CPDs and 6-4PPs. Furthermore, wildtype cells induced a higher expression of DDB2 and xeroderma pigmentosum gene XPC transcript levels than did E2F1−/− cells following UV-C irradiation. Using an E2F SiteScan algorithm, we uncovered a putative E2F-responsive element in the XPC promoter upstream of the transcription start site. We showed with chromatin immunoprecipitation assays the binding of E2F1 to the XPC promoter in a UV-dependent manner, suggesting that E2F1 is a transcriptional regulator of XPC. Our study identifies a novel E2F1 gene target and further supports the growing body of evidence that the Rb/E2F1 tumor suppressor pathway is involved in the regulation of the DNA lesion recognition step of nucleotide excision repair. PMID:19376752

Identification, cloning, and characterization of a major cat flea salivary allergen (Cte f 1).

PubMed

McDermott, M J; Weber, E; Hunter, S; Stedman, K E; Best, E; Frank, G R; Wang, R; Escudero, J; Kuner, J; McCall, C

2000-05-01

An 18 kDa protein isolated from saliva of the cat flea, Ctenocephalides felis, elicits a positive intradermal skin test (IDST) in 100 and 80% of experimental and clinical flea allergic dogs, respectively. Using solid-phase enzyme-linked immuno assay (ELISA), this protein detected IgE in 100 and 80% of experimental and clinical flea allergic dogs, respectively. A cDNA (pFSI) encoding a full-length Cte f 1 protein was isolated from a C. felis salivary gland cDNA library, using a combination of PCR and hybridization screening. This cDNA is 658 bp in length, and contains an open reading frame of 528 bp. The open reading frame encodes a protein of 176 amino acids, consisting of an 18 amino acid signal sequence and a 158 amino acid mature protein. The calculated molecular weight and pI of the mature protein are 18106 Da and 9.3, respectively. The protein, named Cte f 1, is the first novel major allergen described for canine flea allergy. Recombinant Cte f 1 (rCte f 1) was expressed in Escherichia coli, Pichia pastoris and baculovirus infected Trichoplusia ni cells. Approximately, 90% of the rCte f 1 expressed in E. coli accumulated in insoluble inclusion bodies, which could be refolded to a soluble mixture of disulfide isomers with partial IgE binding activity. Small quantities of an apparently correctly refolded form of rCte f 1, which had IgE binding activity equal to the native antigen, was isolated from the soluble fraction of E. coli cells. However, P. pastoris and baculovirus infected insect cells expressed and secreted a fully processed, correctly refolded and fully active form of rCte f 1. Mass spectrometry analysis of the active forms of rCte f 1confirmed that eight intact disulfide bonds were present, matching the number observed in the native allergen. The relative ability of rCte f 1 to bind IgE in the serum of flea allergic animals, produced in these three expression systems, matched that of the native allergen. Competition ELISA demonstrated that approximately 90% of the specific IgE binding to native Cte f 1 could be blocked by the different forms of rCte f 1.

Range Finding 14-Day and 90-Day Subchronic Feeding Studies with N,N-Dipropylcyclohexanecarboxamide in Rats. Phase 4.

DTIC Science & Technology

1986-12-01

Y CLS$1F-.AT N OF THIS...1 MN cD jO 0 -O Ocn00 ~ c" W) 400’ rno n + a9 .9 .i , vi 4 -W cm C44. y c 000 CD %D 1% CD-. U 4 CnN C! - N ON N N TV o 00 e~. r, ML 4r WL ne 0...to N D N4 ’aN N " Nf Y N Nm 00 1C’ bq D Wc iG f". rC W C4 No N N D On ’-0 0 0 f" .4l cc W.4 LoP doE N 04 In Ins. +. V. 0 0 fn 10 C Go 0D C 00’ 4o

Jupiter

NASA Astrophysics Data System (ADS)

Bagenal, Fran; Dowling, Timothy E.; McKinnon, William B.

2007-03-01

Preface; 1. Introduction F. Bagenal, T. E. Dowling and W. B. McKinnon; 2. The origin of Jupiter J. I. Lunine, A. Corandini, D. Gautier, T. C. Owen and G. Wuchterl; 3. The interior of Jupiter T. Guillot, D. J. Stevenson, W. B. Hubbard and D. Saumon; 4. The composition of the atmosphere of Jupiter F. W. Taylor, S. K. Atreya, Th. Encrenaz, D. M. Hunten, P. G. J. Irwin and T. C. Owen; 5. Jovian clouds and haze R. A. West, K. H. Baines, A. J. Friedson, D. Banfield, B. Ragent and F. W. Taylor; 6. Dynamics of Jupiter's atmosphere A. P. Ingersoll, T. E. Dowling, P. J. Gierasch, G. S. Orton, P. L. Read, A. Sánchez-Lavega, A. P. Showman, A. A. Simon-Miller and A. R. Vasavada; 7. The stratosphere of Jupiter J. I. Moses, T. Fouchet, R. V. Yelle, A. J. Friedson, G. S. Orton, B. Bézard, P. Drossart, G. R. Gladstone, T. Kostiuk and T. A. Livengood; 8. Lessons from Shoemaker-Levy 9 about Jupiter and planetary impacts J. Harrington, I. de Pater, S. H. Brecht, D. Deming, V. Meadows, K. Zahnle and P. D. Nicholson; 9. Jupiter's thermosphere and ionosphere R. V. Yelle and S. Miller; 10. Jovian dust: streams, clouds and rings H. Krüger, M. Horányi, A. V. Krivov and A. L. Graps; 11. Jupiter's ring-moon system J. A. Burns, D. P. Simonelli, M. R. Showalter, D. P. Hamilton, C. C. Porco, H. Throop and L. W. Esposito; 12. Jupiter's outer satellites and trojans D. C. Jewitt, S. Sheppard and C. Porco; 13. Interior composition, structure and dynamics of the Galilean satellites G. Schubert, J. D. Anderson, T. Spohn and W. B. McKinnon; 14. The lithosphere and surface of Io A. S. McEwen, L. P. Keszthelyi, R. Lopes, P. M. Schenk and J. R. Spencer; 15. Geology of Europa R. Greeley, C. F. Chyba, J. W. Head III, T. B. McCord, W. B. McKinnon, R. T. Pappalardo and P. Figueredo; 16. Geology of Ganymede R. T. Pappalardo, G. C. Collins, J. W. Head III, P. Helfenstein, T. B. McCord, J. M. Moore, L. M. Procktor, P. M. Shenk and J. R. Spencer; 17. Callisto J. M. Moore, C. R. Chapman. E. B. Bierhaus, R. Greeley, F. C. Chuang, J. Klemaszewski, R. N. Clark, J. B. Dalton, C. A. Hibbitts, P. M. Schenk, J. R. Spencer and R. Wagner; 18. Ages and interiors: the cratering record of the Galilean satellites P. M. Schenk, C. R. Chapman, K. Zahnle and J. M. Moore; 19. Satellite atmospheres M. A. McGrath, E. Lellouch, D. F. Strobel, P. D. Feldman and R. E. Johnson; 20. Radiation effects on the surfaces of the Galilean satellites R. E. Johnson, R. W. Carlson, J. F. Cooper, C. Paranicas, M. H. Moore and M. C. Wong; 21. Magnetospheric interactions with satellites M. G. Kivelson, F. Bagenal, W. S. Kurth, F. M. Neubauer, C. Paranicas and J. Saur; 22. Plasma interactions of Io with its plasma torus J. Saur, F. M. Neubauer, J. E. P. Connerney, P. Zarka and M. G. Kivelson; 23. The Io neutral clouds and plasma torus N. Thomas, F. Bagenal, T. W. Hill and J. K. Wilson; 24. The configuration of Jupiter's magnetosphere K. K. Khurana, M. G. Kivelson, V. M. Vasyliunas, N. Krupp, J. Woch, A. Lagg, B. H. Mauk and W. S. Kurth; 25. Dynamics of the Jovian magnetosphere N. Krupp, V. M. Vasyliunas, J. Woch, A. Lagg, K. K. Khurana, M. G. Kivelson, B. H. Mauk, E. C. Roelof, D. J. Williams, S. M. Krimigis, W. S. Kurth, L. A. Frank and W. R. Paterson; 26. Jupiter's Aurora J. T. Clarke, D. Grodent, S. W. H. Cowley, E. J. Bunce, P. Zarka, J. E. P. Connerney and T. Satoh; 27. Jupiter's inner radiation belts S. J. Bolton, R. M. Thorne, S. Bourdarie, I. de Pater and B. Mauk; Appendix 1. Maps and spectra of Jupiter and the Galilean satellites J. R. Spencer, R. W. Carlson, T. L. Becker and J. S. Blue; Appendix 2. Planetary parameters J. W. Weiss; Index.

Crystal structure and Hirshfeld surface analysis of (2E,2'E)-3,3'-(1,4-phenyl-ene)bis-[1-(2,4-di-fluoro-phen-yl)prop-2-en-1-one].

PubMed

Kwong, Huey Chong; Sim, Aijia; Chidan Kumar, C S; Then, Li Yee; Win, Yip-Foo; Quah, Ching Kheng; Naveen, S; Warad, Ismail

2017-12-01

The asymmetric unit of the title compound, C 24 H 14 F 4 O 2 , comprises of one and a half mol-ecules; the half-mol-ecule is completed by crystallographic inversion symmetry. In the crystal, mol-ecules are linked into a three-dimensional network by C-H⋯F and C-H⋯O hydrogen bonds. Some of the C-H⋯F links are unusually short (< 2.20 Å). Hirshfeld surface analyses ( d norm surfaces and two-dimensional fingerprint plots) for the title compound are presented and discussed.

20 CFR 903.8 - Exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following provisions: subsections (c)(3), (d)(1), (2), (3) and (4), (e)(1), (c)(4)(G), (H) and (I), and (f... of 1974 creates several methods by which individuals may learn of and obtain records containing... investigating such individuals; subsections (d)(1), (e)(4)(H) and (f)(2), (3) and (5) establish the ability of...

Atomic Engineering of Superconductors by Design

DTIC Science & Technology

2014-10-23

Kumah, J. H. Ngai, E. D. Specht , D. A. Arena, F. J. Walker, C. H. Ahn. Phase diagram of compressively strained nickelate thin films, Applied Physics...1940 (2014)10.1002/adma.201304256). 3. A. S. Disa, D. P. Kumah, J. H. Ngai, E. D. Specht , D. A. Arena, F. J. Walker, C. H. Ahn, Phase diagram of

Thin-ice Arctic Acoustic Window (THAAW)

DTIC Science & Technology

2014-09-30

NewYork), pp. 11–37. Mikhalevsky, P. N., Sagen, H., Worcester, P. F., Baggeroer, A. B., Orcutt, J. A., Moore, S. E., Lee, C. M., Vigness -Raposa, K. J...P. F., Baggeroer, A. B., Orcutt, J. A., Moore, S. E., Lee, C. M., Vigness -Raposa, K. J., Freitag, L., Arrott, M., Atakan, K., Beszczynska-Moeller, A

Brief Report: Randomized, Double-Blind Comparison of Tenofovir Alafenamide (TAF) vs Tenofovir Disoproxil Fumarate (TDF), Each Coformulated With Elvitegravir, Cobicistat, and Emtricitabine (E/C/F) for Initial HIV-1 Treatment: Week 144 Results.

PubMed

Arribas, José R; Thompson, Melanie; Sax, Paul E; Haas, Bernhard; McDonald, Cheryl; Wohl, David A; DeJesus, Edwin; Clarke, Amanda E; Guo, Susan; Wang, Hui; Callebaut, Christian; Plummer, Andrew; Cheng, Andrew; Das, Moupali; McCallister, Scott

2017-06-01

In 2 double-blind phase 3 trials, 1733 antiretroviral-naive adults were randomized to tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF), each coformulated with elvitegravir/cobicistat/emtricitabine (E/C/F). At 144 weeks, TAF was superior to TDF in virologic efficacy, with 84.2% vs 80.0% having HIV-1 RNA <50 copies/mL (difference 4.2%; 95% confidence interval: 0.6% to 7.8%). TAF had less impact than TDF on bone mineral density and renal biomarkers. No participants on TAF had renal-related discontinuations vs 12 on TDF (P < 0.001), with no cases of proximal tubulopathy for TAF vs 4 for TDF. There were greater increases in lipids with TAF vs TDF, with no difference in the total cholesterol to high-density lipoprotein ratio. For initial HIV therapy, E/C/F/TAF is superior to E/C/F/TDF in efficacy and bone and renal safety.

Performance of Solid Fuel Ramjet Guided Projectile for USN 5 inch/54 Caliber Gun System

DTIC Science & Technology

1982-03-01

porn .62040.5#01 0.5’)’ ’V 0. SI:1:,3.)~󈨞 13’ 0 0. ?l04 13..1270 0.1 P’E 02 0.?V: 04 1. 21.1?04 95f t 1jfl 0. %1:1 F1’.0Ol’C)1.3 ~ 0 to 11 j :.b17...34 - 0..’’ f: fILFI Dog 0 A OV~AL V STgpi0quATlF SUM1W1.40 Mo 022o-op0.13f-0 .6?r-z 012?-ot .61T.4 FTtPR ENS A NfAVAL POTP~J~ E~li AGr Dal rC

76 FR 51438 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... Rule 17f-2(e) (17 CFR 240.17f-2(e)) under the Securities Exchange Act of 1934 (15 U.S.C. 78a et seq.). Rule 17f-2(e) requires members of national securities exchanges, brokers, dealers, registered transfer... SECURITIES AND EXCHANGE COMMISSION Submission for OMB Review; Comment Request Upon Written Request...

U.S. EPA, Pesticide Product Label, SHACKLE HERBICIDE, 10/31/1988

EPA Pesticide Factsheets

2011-04-14

... IS! ,l,Ro....\\ flOMR 6!DS IQ(tS SH~.j'3~ fI \\,j S ~.l..l'S A',) sr-uJ PH,l''''' 1 j.'; tP,·'o Fe~:I t~~ e~~ 'e (,Jt.I!f btf)f'e I.$. ~it~ ~ P';;

8111/8116 Security Police Staff Officers 8121/8124 Security Police Officers AFSC: 81XX

DTIC Science & Technology

1992-02-01

c 6I4 .1 4 6 5 . 5 6 -6 0 m 0 60 . 0.. C afa 0 -6 0 1 0 .4 L 0 CL & f6 C 6.4 6%. 4 040E .~ ~ a 0 0.41.ft i 0 a 0w m a 2m 2 0 0. Mv 0U 4 0. L.~ 0 0ty...m ~ SC 6& Ct D0 CC Z~C)d Ř-66 64 I Ř.64C0 Ř E~ L 𔄀 6660 LO U64 W . .0 C 𔄀 -4 0L 6 0 L 1- 4 0ŘC C #.4 f6 ൶ 0 151 6W ~ )d6I.ILC E 11 .4 6.4...L - - R~ . ( *U # ACCa .4 % 40 a - 4- 1 4 4-L 0 *-46.40 50 a .40C CL 0 Ŕ 1 0. 0 OUUCC>CU.U0C4-LSa LC .CaC CW~ift-4C .4,4f L .4 -S(( a-..CA a COC *-. 4

Investigations of electron attachment to the perfluorocarbon molecules c-C4F8, 2-C4F8, 1,3 C4F6, and c-C5F8

NASA Astrophysics Data System (ADS)

Feil, Stefan; Märk, Tilmann D.; Mauracher, Andreas; Scheier, Paul; Mayhew, Chris A.

2008-11-01

Non-dissociative and dissociative electron attachment to a series of gas-phase perfluorocarbons (PFCs), namely octafluorocyclobutane, c-C4F8, octafluorobut-2-ene (perfluoro-2-butene), 2-C4F8, hexafluorobuta-1,3-diene (1,3 perfluorobutadiene), 1,3 C4F6, and octafluorocyclopentene (perfluorocyclopentene), c-C5F8, of importance to technological plasmas, have been investigated using two different, but complimentary, instruments available in Innsbruck over the electron energy range 0-20 eV. Anion yields as a function of electron energy have been recorded, with the positions and intensities of the electron attachment resonances being determined. One of these instruments is a double focusing sector field mass spectrometer (VG-ZAB-2SEQ), which has been used for measurements requiring high sensitivity and for obtaining accurate relative anion yields. It has also been used to determine the electron detachment lifetimes of the parent anions under various accelerating voltages, and these results are also presented. The second instrument (CELIA) is a trochoidal electron monochromator coupled to a quadrupole mass filter with a pulse counting system for detecting product anionic species. This provides a much higher energy resolution than the VG-ZAB, which makes it a better instrument to investigate narrow energy resonances close to 0 eV. The results of anion yields, peak positions and the relative intensities presented in this paper are compared with previous data of electron attachment to the above PFCs, including investigations by Professor Eugen Illenberger.

National Dam Safety Program. Lake Wanda Dam (NJ00510), Hudson River Basin, Tributary to Wawayanda Creek, Sussex County, New Jersey. Phase 1 Inspection Report.

DTIC Science & Technology

1980-03-01

8217 7rA’Al’A𔄀 /O’ 3 4 5 $-eS 7W# 55 Af1--7;72 6 10 12 - . . . . . ... . . . . . .’ . . .. 13 l 14 15 £ F6 3I f’f . 16 A6 18 19 200 _.._. . . . .. . . . 21’ 22...191, ~ C! . .. .. C.C C C L. C . C W .C . . . .C .C . . . .C .C . . . . .C . C . C C. . C . C 4 4 . . . a CC aa acca a aa aa C C

The evolution of flaring and non-flaring active regions

NASA Astrophysics Data System (ADS)

Kilcik, A.; Yurchyshyn, V.; Sahin, S.; Sarp, V.; Obridko, V.; Ozguc, A.; Rozelot, J. P.

2018-06-01

According to the modified Zurich classification, sunspot groups are classified into seven different classes (A, B, C, D, E, F and H) based on their morphology and evolution. In this classification, classes A and B, which are small groups, describe the beginning of sunspot evolution, while classes D, E and F describe the large and evolved groups. Class C describes the middle phase of sunspot evolution and the class H describes the end of sunspot evolution. Here, we compare the lifetime and temporal evolution of flaring and non-flaring active regions (ARs), and the flaring effect on ARs in these groups in detail for the last two solar cycles (1996 through 2016). Our main findings are as follows: (i) Flaring sunspot groups have longer lifetimes than non-flaring ones. (ii) Most of the class A, B and C flaring ARs rapidly evolve to higher classes, while this is not applicable for non-flaring ARs. More than 50 per cent of the flaring A, B and C groups changed morphologically, while the remaining D, E, F and H groups did not change remarkably after the flare activity. (iii) 75 per cent of all flaring sunspot groups are large and complex. (iv) There is a significant increase in the sunspot group area in classes A, B, C, D and H after flaring activity. In contrast, the sunspot group area of classes E and F decreased. The sunspot counts of classes D, E and F decreased as well, while classes A, B, C and H showed an increase.

All Prime Contract Awards by State or Country, Place, and Contractor. Part 9 (Annville, Kentucky-Crofton, Maryland)

DTIC Science & Technology

1990-01-01

4.44c V c- U CU4 0 1.- (A 0.0 a* .W - 0. i- -4 C10t- (D I M 6 l UN W 0 >. GN C4 i ae ad )-4N0C, D,0 P. f6 MŔ R~ = 1- (0 00 .8 (A Q 0 0 Zococ3- 00cv I...In 0 P.- CM -4 0 -4 ’I- U u I 000 Go I -16 OC) f6 ’ -4 0A 0 CN - Ll.UC I oo r WNI 00 0 16060 I toN 4: N f 0 L I. I OP.- U -4 -. 4.4 -4 .4.4 .- 46. 4...00 "M M 0i 201(f 1 E00 -4 N)x 0 0 0 Q 0x- 0 0 F6 . Co C4- NI- al 2 0 Wi U) ~ ~ 1. C.) ai a 1 I0 04 N U)N-mN-NN -. 0-4- 1- 4 1.( 4-4 4 (Y00 0 ) -e4 n N

Flight Evaluation of a Linear Optical Displacement Transducer.

DTIC Science & Technology

1983-05-01

2 EDB 2 I’s A 3 %-M . I f I Add AcŘI’s ABA te 2 I A-# A Add .16 .C..v ACCA #852 2993 2 A95 25394 3 A 1..C -A ADC CS 2 2 09 3 2 E9S5 2 F9 4 3 I...Q.. -lit w CJ0 al Lf O CD 40 0n 1 C L. z u 1u wuW L f)f- .) f3 )w003 *92 Ic Qc -I CL 0l a L&cI a I-m L mumKcd-U< -M =unju a racv 0 CM CY- 00C)C)c M4 w4

Collaborative Investigations of Shallow Water Optics Problems

DTIC Science & Technology

2004-12-01

Appendix E. Reprint of Radiative transfer equation inversion: Theory and shape factor models for retrieval of oceanic inherent optical properties, by F ...4829-4834. 5 Hoge, F . E., P. E. Lyon, C. D. Mobley, and L. K. Sundman, 2003. Radiative transfer equation inversion: Theory and shape factor models for...multilinear regression algorithms for the inversion of synthetic ocean colour spectra,, Int. J. Remote Sensing, 25(21), 4829-4834. Hoge, F . E., P. E. Lyon

A Randomized, Open-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIV-1-Infected Adults

PubMed Central

Tebas, Pablo; Gallant, Joel; Wilkin, Timothy; Cheng, Andrew; Yan, Mingjin; Zhong, Lijie; Callebaut, Christian; Custodio, Joseph M.; Fordyce, Marshall W.; Das, Moupali; McCallister, Scott

2017-01-01

Background: HIV-infected, treatment-experienced adults with a history of prior resistance and regimen failure can be virologically suppressed but may require multitablet regimens associated with lower adherence and potential resistance development. Methods: We enrolled HIV-infected, virologically suppressed adults with 2-class to 3-class drug resistance and at least 2 prior regimen failures into this phase 3, open-label, randomized study. The primary endpoint was the percentage of participants with HIV-1 RNA <50 copies per milliliter at week 24 [Food and Drug Administration (FDA) snapshot algorithm]. Results: For 135 participants [elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) plus darunavir (DRV), n = 89; baseline regimen, n = 46], most of whom were taking a median of 5 tablets/d, simplification to E/C/F/TAF plus DRV was noninferior to continuation of baseline regimens at week 24 (plasma HIV-1 RNA <50 copies per milliliter: 96.6% vs. 91.3%, difference 5.3%, 95.001% CI: −3.4% to 17.4%). E/C/F/TAF plus DRV met prespecified criteria for noninferiority and superiority at week 48 for the same outcome. E/C/F/TAF plus DRV was well tolerated and had an improved renal safety profile compared with baseline regimens, with statistically significant differences between groups in quantitative total proteinuria and markers of proximal tubular proteinuria. Compared with baseline regimens, participants who switched to E/C/F/TAF plus DRV reported higher mean treatment satisfaction scale total scores and fewer days with missed doses. Conclusions: This study demonstrated that regimen simplification from a 5-tablet regimen to the 2-tablet, once-daily combination of E/C/F/TAF plus DRV has durable maintenance of virologic suppression and improvements in specific markers of renal safety. Such a strategy may lead to greater adherence and improved quality of life. PMID:27753684

Cytogenetic mapping of the Muller F element genes in Drosophila willistoni group.

PubMed

Pita, Sebastián; Panzera, Yanina; Lúcia da Silva Valente, Vera; de Melo, Zilpa das Graças Silva; Garcia, Carolina; Garcia, Ana Cristina Lauer; Montes, Martín Alejandro; Rohde, Claudia

2014-10-01

Comparative genomics in Drosophila began in 1940, when Muller stated that the ancestral haploid karyotype of this genus is constituted by five acrocentric chromosomes and one dot chromosome, named A to F elements. In some species of the willistoni group such as Drosophila willistoni and D. insularis, the F element, instead of a dot chromosome, has been incorporated into the E element, forming chromosome III (E + F fusion). The aim of this study was to investigate the scope of the E + F fusion in the willistoni group, evaluating six other species. Fluorescent in situ hybridization was used to locate two genes of the F element previously studied-cubitus interruptus (ci) and eyeless (ey)-in species of the willistoni and bocainensis subgroups. Moreover, polytene chromosome photomaps corresponding to the F element (basal portion of chromosome III) were constructed for each species studied. In D. willistoni, D. paulistorum and D. equinoxialis, the ci gene was located in subSectction 78B and the ey gene in 78C. In D. tropicalis, ci was located in subSection 76B and ey in 76C. In species of the bocainensis subgroup, ci and ey were localized, respectively, at subsections 76B and 76C in D. nebulosa and D. capricorni, and 76A and 76C in D. fumipennis. Despite the differences in the subsection numbers, all species showed the same position for ci and ey. The results confirm the synteny of E + F fusion in willistoni and bocainensis subgroups, and allow estimating the occurrence of this event at 15 Mya, at least.

Detail of plaque beneath column on the south parapet at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of plaque beneath column on the south parapet at the west end of the bridge. The plaque reads “1914; Mayor E.J. Drussel; Councilmen E.S. Henry, E.F. Hogan, R.P. Lamdin, C.F. Ross, J.H. Shuppert; Leonard & Day, Engineers; C.H. Gildersleeve, Builder.” - First Street Bridge, Spanning Napa River at First Street between Soscol Avenue & Juarez Street, Napa, Napa County, CA

Research on Fire-Resistant Diesel Fuel.

DTIC Science & Technology

1981-12-01

1[ >1 1? 1F RESEARCH ON FIRE-RESISTANT DIESEL FUEL INTERIM REPORT AFLRL No. 145 By W.D. Weatherford, Jr. G.E. Fodor M.D. Kanakia D.W. Naegeli B.R...GRANT NUMBER(S) W.D. Weatherford, Jr., G.E. Fodor, DAAK7O-80-C-OOO1 M.D. Kanakia, D.W. Naegeli , B.R. Wright (AFLRL) DAAK7O-82-C-OOO1 andF.W...Filters in Fuel Systems of U.S. Army Vehicles I:I , i , , , =- 111 REFERENCES 1. Weatherford, W.D., Jr. Fodor, G.E., Naegeli , D.W., Owens, E.C., Wright

Reforming the Joint Chiefs of Staff.

DTIC Science & Technology

1983-08-01

i . 1. 1 e, * vJ. r ŗi. - .- F-S.., Ar;:it:d ’t i . i . A i r For -::. r ic c.r .m’, I 蟙 a...understandi rig of Lhe Is i ev c:i. tt i on c-f u?e i r -. i t L jon,, Wi thoh U t he benef it of a hi t:or i c.- 1 n-Ii :z I s, there i s a tendency...by criticez- of t. he JCS L i gl IDre t s or i . gi i al purpose& and 1 i mi tat i ons. e r

Molecular characterization of a 40 kDa OmpC-like porin from Serratia marcescens.

PubMed

Hutsul, J A; Worobec, E

1994-02-01

An oligonucleotide that encodes the N-terminal portion of a 41 kDa porin of Serratia marcescens was used to probe S. marcescens UOC-51 genomic DNA. An 11 kb EcoRI fragment which hybridized with the oligonucleotide was subcloned into Escherichia coli, examined for expression, and sequenced. The product expressed by the cloned gene was 40 kDa. The nucleotide sequence has an ORF of 1.13 kb. When the deduced amino acid sequence was aligned and compared to other enterobacterial porins the cloned S. marcescens porin most closely resembled E. coli OmpC. Although we did not detect osmoregulation or thermoregulation of any porins in S. marcescens UOC-51, sequences analogous to the E. coli osmoregulator OmpR-binding regions are seen upstream to the cloned gene. We examined the regulation of the S. marcescens porin in E. coli and found that its expression increased in a high salt environment. A micF gene, whose transcriptional product functions to inhibit synthesis of OmpF by hybridizing with the ompF transcript, was also seen upstream of the S. marcescens ompC. An alignment with the E. coli micF gene revealed that the functional region of the S. marcescens micF gene is conserved. Based on the results obtained we have determined that S. marcescens UOC-51 produces a 40 kDa porin similar to the E. coli OmpC porin.

Automated cGMP-compliant radiosynthesis of [18 F]-(E)-PSS232 for brain PET imaging of metabotropic glutamate receptor subtype 5.

PubMed

Park, Jun Young; Son, Jeongmin; Yun, Mijin; Ametamey, Simon M; Chun, Joong-Hyun

2018-01-01

(E)-3-(Pyridin-2-yl ethynyl)cyclohex-2-enone O-(3-(2-[ 18 F]-fluoroethoxy)propyl) oxime ([ 18 F]-(E)-PSS232, [ 18 F]2a) is a recently developed radiotracer that can be used to visualize metabotropic glutamate receptor subtype 5 (mGlu 5 ) in vivo. The mGlu 5 has become an attractive therapeutic and diagnostic target owing to its role in many neuropsychiatric disorders. Several carbon-11-labeled and fluorine-18-labeled radiotracers have been developed to measure mGlu 5 receptor occupancy in the human brain. The radiotracer [ 18 F]2a, which is used as an analogue for [ 11 C]ABP688 ([ 11 C]1) and has a longer physical half-life, is a selective radiotracer that exhibits high binding affinity for mGlu 5 . Herein, we report the fully automated radiosynthesis of [ 18 F]2a using a commercial GE TRACERlab™ FX- FN synthesizer for routine production and distribution to nearby satellite clinics. Nucleophilic substitution of the corresponding mesylate precursor with cyclotron-produced [ 18 F]fluoride ion at 100°C in dimethyl sulfoxide (DMSO), followed by high-performance liquid chromatography (HPLC) purification and formulation, readily provided [ 18 F]2a with a radiochemical yield of 40 ± 2% (decay corrected, n = 5) at the end of synthesis. Radiochemical purity for the [ 18 F]-(E)-conformer was greater than 95%. Molar activity was determined to be 63.6 ± 9.6 GBq/μmol (n = 5), and the overall synthesis time was 70 minutes. Copyright © 2017 John Wiley & Sons, Ltd.

Temperature sensing in Yersinia pestis: regulation of yopE transcription by lcrF.

PubMed Central

Hoe, N P; Minion, F C; Goguen, J D

1992-01-01

In Escherichia coli, a yopE::lacZ fusion was found to be regulated by temperature in the presence of the cloned BamHI G fragment of Yersinia pestis plasmid pCD1, which contains the lcrF locus. Increasing the copy number of lcrF relative to that of the yopE reporter had a negligible effect on the induction ratio (26 versus 37 degrees C) but caused large reductions in the absolute levels of yopE transcription. We localized the lcrF gene by monitoring the induction phenotype of BamHI G deletion derivatives. Sequencing revealed an open reading frame capable of encoding a protein of 30.8 kDa. A protein product of this size was detected in a T7 expression system, and LcrF-dependent yopE-specific DNA binding activity was observed. As expected, LcrF exhibited 98% homology to VirF of Yersinia enterocolitica and significant homology to the carboxy termini of other members of the AraC family of transcriptional regulatory proteins. These proteins could be divided into two classes according to function: those regulating operons involved in catabolism of carbon and energy sources and those involved in regulating virulence genes. lcrF::lacZ transcriptional fusions were constructed and analyzed in Y. pestis and E. coli. The activity of the fusions was not affected by the native pCD1 virulence plasmid, an intact lcrF gene, or temperature. Thus, induction of lcrF transcription is not essential for temperature-dependent activation of yopE transcription. A portion of LcrF was found associated with the membrane fraction in E. coli; however, pulse-chase experiments indicated that this result is an artifact of fractionation. Images PMID:1624422

Soil contamination with olive mill wastes negatively affects microbial communities, invertebrates and plants.

PubMed

Hentati, Olfa; Oliveira, Vanessa; Sena, Clara; Bouji, Mohamed Seddik Mahmoud; Wali, Ahmed; Ksibi, Mohamed

2016-10-01

The aim of the present study was to evaluate the ecotoxicological effects of olive mill waste (OMW) on soil habitat function. To this end, soil samples from OMW evaporating ponds (S1-S5) located at Agareb (Sfax, Tunisia) and a reference soil (R) were collected. The effects of OMW on the springtails Folsomia candida (F.c.), the earthworm species Eisenia fetida (E.f.), Enchytraeus crypticus (E.c.) reproduction and on the soil living microbial communities were investigated. E.f. reproduction and tomato growth assays were performed in the reference soil amended with 0.43 to 7.60 % (w OMW /w ref-soil ) mass ratios of dried OMW. Changes in microbial function diversity were explored using sole-carbon-source utilization profiles (BiologEcoPlates ® ). E.f. absolutely avoided (100 %) the most polluted soil (S4) while the F.c. moderately avoided (37.5 ± 7.5 %) the same soil. E.c. reproduction in S4 was significantly lower than in S1, S2, S3 and S5, and was the highest in R soil. Estimated effect concentration EC 50 for juveniles' production by E.f., and for tomato fresh weight and chlorophyll content were 0.138, 0.6 and 1.13 %, respectively. Community level physiological profiles (CLPPs) were remarkably different in R and S4 and a higher similarity was observed between soils S1, S2, S3 and S5. Principal component analysis (PCA) revealed that differences between soil microbial functional diversity were mainly due to high polyphenol concentrations, while the salinity negatively affected E.c. reproduction in OMW contaminated soils. These results clearly reflect the high toxicity of dried OMW when added to agricultural soils, causing severe threats to terrestrial ecosystem functions and services provided by invertebrates and microbial communities.

Energy Savings Opportunity Survey (ESOS) of Schofield Barracks Family Housing, Areas A, D, E, F, I, J, K-1. Volume 1

DTIC Science & Technology

1992-09-09

Q ^ C. DESIGN COST £|0*7o) j O .?>?, D. ENERGY CREDIT CALC (1A+1B+1CJX.9 j 3 3j / Lf C. SALVAGE VALUE OF EXISTING EQUIPMENT...BY INVESTMFNT COSTS A. CONSTRUCTION COST ß. SIOH CS-S^O C. DESIGN COST £ 10*7»^ Ü. ENERGY CREDIT CALC (1A*1B+1C)X.9 E. SALVAGE VALUE OF...COST B. SIOH CS-S^O C. DESIGN COST ( lo7o") Ü. ENERGY CREDIT CALC (1A+IB+1C)X.9 E. SALVAGE VALUE OF EXISTING EQUIPMENT F. TOTAL INVESTMENT (ID-IE

Painful Charcot-Marie-Tooth neuropathy type 2E/1F due to a novel NEFL mutation.

PubMed

Doppler, Kathrin; Kunstmann, Erdmute; Krüger, Stefan; Sommer, Claudia

2017-05-01

Charcot-Marie-Tooth neuropathy (CMT) 2E/1F is caused by mutations in the neurofilament light-chain polypeptide (NEFL) gene. Giant axons are a histological hallmark frequently seen in nerves of patients with CMT2E. We describe the case of a 43-year-old patient with a painful, predominantly sensory neuropathy. The patient's sural nerve biopsy showed multiple giant axons. Genetic sequencing of the NEFL gene revealed that the patient was heterozygous for an altered sequence of the gene, c.816C>G, p.Asn272Lys, which has not yet been described in CMT2E/1F. In contrast to other cases of CMT2E/1F, where motor symptoms are predominant, pain was the most disabling symptom in this patient. Muscle Nerve 55: 752-755, 2017. © 2016 Wiley Periodicals, Inc.

cDNA cloning and immunological characterization of a newly identified enolase allergen from Penicillium citrinum and Aspergillus fumigatus.

PubMed

Lai, Hsiu-Yu; Tam, Ming F; Tang, Ren-Bin; Chou, Hong; Chang, Ching-Yun; Tsai, Jaw-Ji; Shen, Horng-Der

2002-03-01

Penicillium citrinum and Aspergillus fumigatus are prevalent indoor airborne fungal species that have been implicated in human respiratory allergic disorders. It is important to understand the allergenic profile of these fungal species. The purpose of the present study is to characterize a newly identified enolase allergen from P. citrinum and A. fumigatus. Fungal proteins were separated by two-dimensional (2D) gel electrophoresis and blotted onto polyvinylidene difluoride membranes. Protein spots that reacted with IgE antibodies in serum samples from asthmatic patients were identified and the N-terminal amino acid sequences were determined by Edman degradation. The peptide sequences obtained were utilized in cloning the cDNA of the allergen genes by reverse transcriptase-polymerase chain reaction and the 5'- and 3'-rapid amplification cDNA end reactions. Our results from 2D immunoblotting identified a 47-kD IgE-reactive component in the extracts of P. citrinum and A. fumigatus. The N-terminal amino acid sequences of the 47-kD proteins are homologous to those of fungal enolases. The corresponding enolase cDNA from P. citrinum contains 1,552 bp and encodes a protein of 438 residues. In A. fumigatus, the isolated enolase cDNA has 1,649 bp and contains a 438-amino acid open reading frame. The deduced amino acid sequences of these two enolases have 94% identity. These enolases from P. citrinum and A. fumigatus were expressed in Escherichia coli as a His-tagged protein and designated as rPen c 22 and rAsp f 22, respectively. Sera from 7 (30%) of the 23 Penicillium-sensitized asthmatic patients showed IgE binding to the 47-kD P. citrinum component (Pen c 22) and rPen c 22. In addition, six of seven Pen c 22-positive serum samples have IgE immunoblot reactivity to the 47-kD A. fumigatus component (Asp f 22) and rAsp f 22. A polyclonal rabbit antiserum generated against the N-terminal peptide of Pen c 22 can react with Pen c 22, rPen c 22, Asp f 22 and rAsp f 22. In addition, the presence of IgE cross-reactivity between rPen c 22 and rAsp f 22 and between enolases from A. fumigatus and Alternaria alternata was also detected by immunoblot inhibition. These results demonstrated that a novel enolase allergen from P. citrinum (Pen c 22) and A. fumigatus (Asp f 22) was identified. In addition, IgE cross-reactivity between enolase allergens from A. fumigatus and P. citrinum and between enolases from A. fumigatus and A. alternata was also detected. Results obtained provide more information on fungal enolase allergens. Copyright 2002 S. Karger AG, Basel

The role of the hippocampus in transitive inference

PubMed Central

Zalesak, Martin; Heckers, Stephan

2009-01-01

Transitive inference (TI) is the ability to infer the relationship between items (e.g., A>C) after having learned a set of premise pairs (e.g., A>B and B>C). Previous studies in humans have identified a distributed neural network, including cortex, hippocampus, and thalamus, during TI judgments. We studied two aspects of TI using fMRI of subjects who had acquired the 6-item sequence (A>B>C>D>E>F) of visual stimuli. First, the identification of novel pairs not containing end items (i.e., B>D, C>E, B>E) was associated with greater left hippocampal activation when compared to the identification of novel pairs containing end items A and F. This demonstrates that the identification of stimulus pairs requiring the flexible representation of a sequence is associated with hippocampal activation. Second, for the three novel pairs devoid of end items we found greater right hippocampal activation for pairs B>D and C>E compared with pair B>E. This indicates that TI decisions on pairs derived from more adjacent items in the sequence are associated with greater hippocampal activation. Hippocampal activation thus scales with the degree of relational processing necessary for TI judgments. Both findings confirm a role of the hippocampus in transitive inference in humans. PMID:19216061

Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells.

PubMed

Reifenberger, Matthew S; Yu, Ling; Bao, Hui-Fang; Duke, Billie Jeanne; Liu, Bing-Chen; Ma, He-Ping; Alli, Ahmed A; Eaton, Douglas C; Alli, Abdel A

2014-07-01

Numerous reports have linked cytoskeleton-associated proteins with the regulation of epithelial Na(+) channel (ENaC) activity. The purpose of the present study was to determine the effect of actin cytoskeleton disruption by cytochalasin E on ENaC activity in Xenopus 2F3 cells. Here, we show that cytochalasin E treatment for 60 min can disrupt the integrity of the actin cytoskeleton in cultured Xenopus 2F3 cells. We show using single channel patch-clamp experiments and measurements of short-circuit current that ENaC activity, but not its density, is altered by cytochalasin E-induced disruption of the cytoskeleton. In nontreated cells, 8 of 33 patches (24%) had no measurable ENaC activity, whereas in cytochalasin E-treated cells, 17 of 32 patches (53%) had no activity. Analysis of those patches that did contain ENaC activity showed channel open probability significantly decreased from 0.081 ± 0.01 in nontreated cells to 0.043 ± 0.01 in cells treated with cytochalasin E. Transepithelial current from mpkCCD cells treated with cytochalasin E, cytochalasin D, or latrunculin B for 60 min was decreased compared with vehicle-treated cells. The subcellular expression of fodrin changed significantly, and several protein elements of the cytoskeleton decreased at least twofold after 60 min of cytochalasin E treatment. Cytochalasin E treatment disrupted the association between ENaC and myristoylated alanine-rich C-kinase substrate. The results presented here suggest disruption of the actin cytoskeleton by different compounds can attenuate ENaC activity through a mechanism involving changes in the subcellular expression of fodrin, several elements of the cytoskeleton, and destabilization of the ENaC-myristoylated alanine-rich C-kinase substrate complex. Copyright © 2014 the American Physiological Society.

Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells

PubMed Central

Reifenberger, Matthew S.; Yu, Ling; Bao, Hui-Fang; Duke, Billie Jeanne; Liu, Bing-Chen; Ma, He-Ping; Eaton, Douglas C.; Alli, Abdel A.

2014-01-01

Numerous reports have linked cytoskeleton-associated proteins with the regulation of epithelial Na+ channel (ENaC) activity. The purpose of the present study was to determine the effect of actin cytoskeleton disruption by cytochalasin E on ENaC activity in Xenopus 2F3 cells. Here, we show that cytochalasin E treatment for 60 min can disrupt the integrity of the actin cytoskeleton in cultured Xenopus 2F3 cells. We show using single channel patch-clamp experiments and measurements of short-circuit current that ENaC activity, but not its density, is altered by cytochalasin E-induced disruption of the cytoskeleton. In nontreated cells, 8 of 33 patches (24%) had no measurable ENaC activity, whereas in cytochalasin E-treated cells, 17 of 32 patches (53%) had no activity. Analysis of those patches that did contain ENaC activity showed channel open probability significantly decreased from 0.081 ± 0.01 in nontreated cells to 0.043 ± 0.01 in cells treated with cytochalasin E. Transepithelial current from mpkCCD cells treated with cytochalasin E, cytochalasin D, or latrunculin B for 60 min was decreased compared with vehicle-treated cells. The subcellular expression of fodrin changed significantly, and several protein elements of the cytoskeleton decreased at least twofold after 60 min of cytochalasin E treatment. Cytochalasin E treatment disrupted the association between ENaC and myristoylated alanine-rich C-kinase substrate. The results presented here suggest disruption of the actin cytoskeleton by different compounds can attenuate ENaC activity through a mechanism involving changes in the subcellular expression of fodrin, several elements of the cytoskeleton, and destabilization of the ENaC-myristoylated alanine-rich C-kinase substrate complex. PMID:24829507

U.S. EPA, Pesticide Product Label, PURITY BACTERIOSTATIC WATER TREATMENT UNIT,MODEL 514C.C., 09/10/1982

EPA Pesticide Factsheets

2011-04-21

... [ .... EEO PL"',lI.', Pl:>1S:. .. · nAG.',EEJ A€~f)EA~''''ETTlE RE::'f-o':'::l P,G'.H:JR;)S",lhPEt. ... ','.! Pf" g':-'" iI~~~ 2.- ~~. I.~r 0" S' l_t e I.l'l ~aM;: .I.,. ...

48 CFR 1827.302 - Policy. (NASA supplements paragraphs (a), (b), (c), (d), (e), (f), (g), and (i)).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. (NASA supplements paragraphs (a), (b), (c), (d), (e), (f), (g), and (i)). 1827.302 Section 1827.302 Federal Acquisition... the performance of experimental, developmental, or research work with a small business firm or a...

Mooring Operations for Thin-Ice Arctic Acoustic Window (THAAW) Project

DTIC Science & Technology

2015-05-20

Moore, S. E., Lee, C. M., Vigness -Raposa, K. J., Freitag, L., Arrott, M., Atakan, K., Beszczynska-Möller, A., Duda, T. F., Dushaw, B. D., Gascard, J...PUBLICATIONS AND PRESENTATIONS Mikhalevsky, P. N., Sagen, H., Worcester, P. F., Baggeroer, A. B., Orcutt, J., Moore, S. E., Lee, C. M., Vigness -Raposa, K. J

U.S. EPA, Pesticide Product Label, WORKHOURSE SAPSTAIN AND MOLD CONTROL PRODUCT, 02/19/2008

EPA Pesticide Factsheets

2011-04-21

... ' the .R,~lstrat~~C;~t:'ISlori prior., t9,,4!le ,0f.me!~~~U,,'cornrr'erc~. ,In a~¥ cOir~~r&rdenc~i~n ttils'product alw.aY,Sr~f!ilr,to~~,;~eE;P~~~ . 'y ", ...

Camp Casey, Tongduchon, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1981-02-10

76.,a41 7S.4 ?R.4’ 7B.q. .4 . I 78.uf 7-.t- . .I 2 V_𔃻 77.71 77.71 72.2 f6 . I 7 -.. 4 78. . ,= , 9Ss 7. 7. ’ 7 .Z 7 7 79.Z 79.2 79.1-3; 77. 7 79.a: 75...cof-. .4r E0C >j a- -- =* C.j C . = ± (i3e!’ afl o oc- g Nta.. a .o.r3azdflloD2Coa.aoc a- f~ie~~z. n.!. G a 4 . ACca . . rx Co.--&Z3Er,0C i1DaI Da...6-=.1 66.4 ;-’ -0 o-b 915 c.01 is 99.2i 90.7 99.7 9 9. 1 99.7s. JO 200 1 5 01 6 ,. 1 66.4! .69 F6 . 1 ? 1 .61 976.1if 97.r1 99. 1 9gs 999 .39 a c .3 c

High Resolution Transmission Measurements of the Atmosphere in the Infrared.

DTIC Science & Technology

1978-04-28

modifications to the various spect rorn et r ic installations , cu r r en t l y operated to obtain very hi g h resolution solar spectra in the in f r a...record the solar spectrum in the ~‘. 3000 to ~ 10 , 000 A reg ion , has also been equipped with an InSb detector to recorc various series of spectra near...in~ s c o n c e r n i n & HF , HC 1, also met hy l-ch lor ide (CH 3C1), e t c . . . L t h e r s tudies oased on our i n f r a r e d solar ou se

A Study of Normal Shock-Wave Turbulent Boundary-Layer Interactions at Mach Numbers of 1.3, 1.4 and 1.5.

DTIC Science & Technology

1982-10-01

Veigas 13used a third technique which was to hold the normal shock wave steady in a supersonic tube by the adjustment of a conical choke downstream of...the equilibrium functioii E (equation (3) as tie eqoi ihri:’ fl -it I lows of East, Sawyer and Nash 2 8 . Although the maximum values of ti wakce :, i...f.. ..l.. .. .. ..t.. fl iC!alaCC CCCCCCCCt t CCCCCifllt CCCCCCCCit C C--- ---- -- C A CCC5C tCC C NC C - f CC1S $ C C A * E~ - - C 2

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (International Const. Co. Ltd.-McKay Communications)

DTIC Science & Technology

1993-01-01

a4 a -- 0 a ,r 00 a.H Va CO u 0 0~ a. a . a 404~~ x- 4z. . . a a a. a~~~c. a WOw C6 Cr a D 00 - aa a a a3 a . Ca.~ ~ 0 acca rI a. az 0-. a 0 a 0 aD...4Ed V-4E ) F .4 ~ F 0.4 00. F4C n- F EL F: F3. xL O F-F,-.1~~~~F o)40 F en0 F (F 1. F 0 4 4 4 4 41 F6 F6 F8 a F6. 6 a 444~ F) 44 F) 4 0 4~~~ ccFF 0

Identifying the Flow Physics and Modeling Transient Forces on Two-Dimensional Wings

DTIC Science & Technology

2016-09-02

MODELS USING EDMD (a) ( b ) (c) (d) ( e ) (f) (g) (h... Model EDMD Model , β = 0.5 EDMD Model , optimal β ( b ) Model order 5 10 15 20 25 L im it c y c le f re q u e n c y 0.12 0.125 0.13 0.135 0.14 0.145...GP and EDMD nonlinear models in predicting the evolution of POD coefficients for transitional flow past a cylinder, showing (a) time evolution and ( b

Reliability Test and Evaluation of MIL-M-38510 Linear Microcircuits

DTIC Science & Technology

1979-07-01

KIKLMNALL V ;ILI,, IN AuAI? 0. LXCLs’.SIV. AuAI2 GROWTH DJURING BOWIN)G A. 0111N PIN I OR 3 102000 1@6 6.2 3 . B1•’• EN fITENRNAL IEA C. MIECHANICAL...JC U- 0 CDI 0 09 c C L C4 C" CA .-. 0. C IN U- Ci3 e 0. .-4 CD C5 0c oc i en 0c, O~ - LUi C. co m 0 (0F59 TABLE F8- 3 - IB VcM = OV) HISTORY OF THE...F64 Gl through G4 LIST OF FIGURES FIGURE PAGE 1 LINEAR MICROCIRCUIT TEST PROGRAM .......... ............... 3 2 ACCELERATED LIFE TEST BIAS CIRCUITS

Determination of size and sign of hetero-nuclear coupling constants from 2D 19F-13C correlation spectra.

PubMed

Ampt, Kirsten A M; Aspers, Ruud L E G; Dvortsak, Peter; van der Werf, Ramon M; Wijmenga, Sybren S; Jaeger, Martin

2012-02-01

Fluorinated organic compounds have become increasingly important within the polymer and the pharmaceutical industry as well as for clinical applications. For the structural elucidation of such compounds, NMR experiments with fluorine detection are of great value due to the favorable NMR properties of the fluorine nucleus. For the investigation of three fluorinated compounds, triple resonance 2D HSQC and HMBC experiments were adopted to fluorine detection with carbon and/or proton decoupling to yield F-C, F-C{H}, F-C{C(acq)} and F-C{H,C(acq)} variants. Analysis of E.COSY type cross-peak patterns in the F-C correlation spectra led, apart from the chemical shift assignments, to determination of size and signs of the J(CH), J(CF), and J(HF) coupling constants. In addition, the fully coupled F-C HMQC spectrum of steroid 1 was interpreted in terms of E.COSY type patterns. This example shows how coupling constants due to different nuclei can be determined together with their relative signs from a single spectrum. The analysis of cross-peak patterns, as presented here, not only provides relatively straightforward routes to the determination of size and sign of hetero-nuclear J-couplings in fluorinated compounds, it also provides new and easy ways for the determination of residual dipolar couplings and thus for structure elucidation. The examples and results presented in this study may contribute to a better interpretation and understanding of various F-C correlation experiments and thereby stimulate their utilization. Copyright © 2011 Elsevier Inc. All rights reserved.

Dissecting the Molecular Mechanism of RhoC GTPase Expression in the Normal and Malignant Breast

DTIC Science & Technology

2011-09-01

and cancer. Nature reviews 2, 133-142. Valastyan, S., Reinhardt, F ., Benaich, N., Calogrias, D., Szasz, A.M., Wang, Z.C., Brock, J.E., Richardson...prostate cancer progression. Cancer cell 17, 443-454.   R ho C F IS H Normal SUM149 SUM190A Figure 1 75 75 75 0 0 0 0 200 R ea ds (R P K M ) R...RhoC A B C D Figure 3 0 5 10 15 20 25 HME MCF7 SUM149 MDA-MB-231 Fo ld E nr ic hm en t o f p 65 B in di ng p65 (-2834) p65 (-2259) p65 (-6) A B

77 FR 1656 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, R...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

...-0117; Airspace Docket No. 09-AGL-31] RIN 2120-AI92 Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND AGENCY: Federal Aviation... Restricted Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND (76 FR 72869...

46 CFR 164.023-5 - Performance; standard thread.

Code of Federal Regulations, 2011 CFR

2011-10-01

... specification Material Type Class Ticket No. or size range V-T-285E Polyester I or II 1 E, F, FF. V-T-295E Nylon I or II A E, F, FF. MIL-T-43624A Polyester 24 through 12. MIL-T-43548C Polyester covered only 24...

46 CFR 164.023-5 - Performance; standard thread.

Code of Federal Regulations, 2010 CFR

2010-10-01

... specification Material Type Class Ticket No. or size range V-T-285E Polyester I or II 1 E, F, FF. V-T-295E Nylon I or II A E, F, FF. MIL-T-43624A Polyester 24 through 12. MIL-T-43548C Polyester covered only 24...

Avionics Interface Data Summaries: A-10A, EF-111A, F-4E, F-4G, F-15A, F- 16A, F-111A, F-111E, F-111F, RF-4C

DTIC Science & Technology

1979-10-01

AIRCRAFT Flight Control ASA-32( ) Flight Director Computer TBD (Same as non -ARN-101 equipped F-4E aircraft) Air Data Computer CPK-92/A24G-34 Attitude...below. A two-inch separation between cable types is arbitrarily set as a minimum design goal. 3.2.6.4.1 Power and Control Circuits. Roucing and channel...plan in accordance with MIL-STD-461A(3) shall be the controlling document for EMIC design . 3.2.7.1 Design Reuire-nents. The generation of and suscepti

Preparation & characterization of SiO{sub 2} interface layer by dip coating technique on carbon fibre for C{sub f}/SiC composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Kundan, E-mail: kundanemails@gmail.com; Centre for Nanotechnology, Central University of Jharkhand, Ratu-Lohardaga Road, Brambe, Ranchi-835205 INDIA; Jariwala, C., E-mail: chetan@ipr.res.in

Carbon fibres (C{sub f}) are one of the most important reinforced materials for ceramic matrix composites such as C{sub f} - SiC composites and they are generally sought for high temperature applications in as space application, nuclear reactor and automobile industries. But the major problem arise when C{sub f} reinforced composites exposed to high temperature in an oxidizing environment, C{sub f} react with oxygen and burnt away. In present work, we have studied the effect of silica (SiO{sub 2}) coating as a protective coating on C{sub f} for the C{sub f} / SiC composites. The silica solution prepared by themore » sol-gel process and coating on C{sub f} is done by dip coating technique with varying the withdrawing speed i.e. 2, 5, 8 mm/s with fixed dipping cycle (3 Nos.). The uniform silica coating on the C{sub f} is shown by the Scanning Electron Microscope (SEM) analysis. The tensile test shows the increase in tensile strength with respect to increase in withdrawing speed. The isothermal oxidation analysis confirmed enhancement of oxidation resistance of silica coated C{sub f} as compared tothe uncoated C{sub f}.« less

Improved Mechanical Properties and Ozone Resistance of Radiation Cured SBR

DTIC Science & Technology

1991-08-01

c ) n i.rmed and...ro L 9L or; < K C F 0 0F 0 Ii\\ N C C ).- 0 E 0 -o - -,-,° 0 0 . .. . .... _>. >, ŔGZ r -,’oo-00"- -- - - ’Iv ! [" -, 1 r ,G , -" ’-A o, o 0 0 0 0 /- 0...rad. 25 TABLE 5 -8O ZO N E RESIST .AN C TEST FO R SA M PLES PR EPA R ED BY INDUSTR’Ai- PARTICIPANTS Ozone Resistance"I Formulation No. Of No. Of

U.S. EPA, Pesticide Product Label, , 07/16/1984

EPA Pesticide Factsheets

2011-04-13

... A t • .." L..~r · ... ho ." sl,cs to I'O'~' "_'1' ': ~~ _~;' [ • 1/.1',1,.,\\ . I~'e rrvH ct ·.ll~ a perm,1 .0 .... 'f" C; '.J f- 11 l' ~ .. ' J~ •..• fJ\\.. If ~ .... C1 .. t 10 RellA ...

Product Stochastic Measures, Multiple Stochastic Integrals and Their Extensions to Nuclear Space Valued Processes.

DTIC Science & Technology

1985-06-01

8217 - - - .-. ’ - - ’. : - . L - • • - . " -" 21 where the supremum is taken over all finite partitions (A.) of Aointo dis - joint sets Ac C A 0and all...1 Afm (t) = Z aT 1A (t) • j=lJ j n then from (2.3.2) and the definition of sv( e Xi;A) i n 2 ni,": II~~1f A / mr(t-- di * X. (t) II Hen = II j~ l a’m...n and -fT fd 12 M(. Ci 2 Et 11 11 (lf(C k))e = lim ED iml j1 l 4 n = lir exp( fn f 2 di ) = exp(f f2d) < L.n -Ko T UTT. i= l which shows (a). Let 1,E2

Krüppel-like factor 1 mutations and expression of hemoglobins F and A2 in homozygous hemoglobin E syndrome.

PubMed

Tepakhan, Wanicha; Yamsri, Supawadee; Fucharoen, Goonnapa; Sanchaisuriya, Kanokwan; Fucharoen, Supan

2015-07-01

The basis for variability of hemoglobin (Hb) F in homozygous Hb E disease is not well understood. We have examined multiple mutations of the Krüppel-like factor 1 (KLF1) gene; an erythroid specific transcription factor and determined their associations with Hbs F and A2 expression in homozygous Hb E. Four KLF1 mutations including G176AfsX179, T334R, R238H, and -154 (C-T) were screened using specific PCR assays on 461 subjects with homozygous Hb E and 100 normal controls. None of these four mutations were observed in 100 normal controls. Among 461 subjects with homozygous Hb E, 306 had high (≥5 %) and 155 had low (<5 %) Hb F. DNA analysis identified the KLF1 mutations in 35 cases of the former group with high Hb F, including the G176AfsX179 mutation (17/306 = 5.6 %), T334R mutation (9/306 = 2.9 %), -154 (C-T) mutation (7/306 = 2.3 %), and R328H mutation (2/306 = 0.7 %). Only two subjects in the latter group with low Hb F carried the G176AfsX179 and -154 (C-T) mutations. Significant higher Hb A2 level was observed in those of homozygous Hb E with the G176AfsX179 mutation as compared to those without KLF1 mutations. These results indicate that KLF1 is among the genetic factors associated with increased Hbs F and A2, and in combination with other factors could explain the variabilities of these Hb expression in Hb E syndrome.

Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients.

PubMed

Lucas, C M; Harris, R J; Holcroft, A K; Scott, L J; Carmell, N; McDonald, E; Polydoros, F; Clark, R E

2015-07-01

High cancerous inhibitor of PP2A (CIP2A) protein levels at diagnosis of chronic myeloid leukaemia (CML) are predictive of disease progression in imatinib-treated patients. It is not known whether this is true in patients treated with second generation tyrosine kinase inhibitors (2G TKI) from diagnosis, and whether 2G TKIs modulate the CIP2A pathway. Here, we show that patients with high diagnostic CIP2A levels who receive a 2G TKI do not progress, unlike those treated with imatinib (P=<0.0001). 2G TKIs induce more potent suppression of CIP2A and c-Myc than imatinib. The transcription factor E2F1 is elevated in high CIP2A patients and following 1 month of in vivo treatment 2G TKIs suppress E2F1 and reduce CIP2A; these effects are not seen with imatinib. Silencing of CIP2A, c-Myc or E2F1 in K562 cells or CML CD34+ cells reactivates PP2A leading to BCR-ABL suppression. CIP2A increases proliferation and this is only reduced by 2G TKIs. Patients with high CIP2A levels should be offered 2G TKI treatment in preference to imatinib. 2G TKIs disrupt the CIP2A/c-Myc/E2F1 positive feedback loop, leading to lower disease progression risk. The data supports the view that CIP2A inhibits PP2Ac, stabilising E2F1, creating a CIP2A/c-Myc/E2F1 positive feedback loop, which imatinib cannot overcome.

CdiA Effectors from Uropathogenic Escherichia coli Use Heterotrimeric Osmoporins as Receptors to Recognize Target Bacteria

PubMed Central

Beck, Christina M.; Willett, Julia L. E.; Kim, Jeff J.; Low, David A.; Hayes, Christopher S.

2016-01-01

Many Gram-negative bacterial pathogens express contact-dependent growth inhibition (CDI) systems that promote cell-cell interaction. CDI+ bacteria express surface CdiA effector proteins, which transfer their C-terminal toxin domains into susceptible target cells upon binding to specific receptors. CDI+ cells also produce immunity proteins that neutralize the toxin domains delivered from neighboring siblings. Here, we show that CdiAEC536 from uropathogenic Escherichia coli 536 (EC536) uses OmpC and OmpF as receptors to recognize target bacteria. E. coli mutants lacking either ompF or ompC are resistant to CDIEC536-mediated growth inhibition, and both porins are required for target-cell adhesion to inhibitors that express CdiAEC536. Experiments with single-chain OmpF fusions indicate that the CdiAEC536 receptor is heterotrimeric OmpC-OmpF. Because the OmpC and OmpF porins are under selective pressure from bacteriophages and host immune systems, their surface-exposed loops vary between E. coli isolates. OmpC polymorphism has a significant impact on CDIEC536 mediated competition, with many E. coli isolates expressing alleles that are not recognized by CdiAEC536. Analyses of recombinant OmpC chimeras suggest that extracellular loops L4 and L5 are important recognition epitopes for CdiAEC536. Loops L4 and L5 also account for much of the sequence variability between E. coli OmpC proteins, raising the possibility that CDI contributes to the selective pressure driving OmpC diversification. We find that the most efficient CdiAEC536 receptors are encoded by isolates that carry the same cdi gene cluster as E. coli 536. Thus, it appears that CdiA effectors often bind preferentially to "self" receptors, thereby promoting interactions between sibling cells. As a consequence, these effector proteins cannot recognize nor suppress the growth of many potential competitors. These findings suggest that self-recognition and kin selection are important functions of CDI. PMID:27723824

CF3+ fragmentation by electron impact ionization of perfluoro-propyl-vinyl-ethers, C5F10O, in gas phase

NASA Astrophysics Data System (ADS)

Kondo, Yusuke; Ishikawa, Kenji; Hayashi, Toshio; Miyawaki, Yudai; Takeda, Keigo; Kondo, Hiroki; Sekine, Makoto; Hori, Masaru

2015-04-01

The gas phase fragmentations of perfluoro-propyl-vinyl ether (PPVE, C5F10O) are studied experimentally. Dominant fragmentations of PPVE are found to be the result of a dissociative ionization reaction, i.e., CF3+ via direct bond cleavage, and C2F3O- and C3F7O- via electron attachment. Regardless of the appearance energy of around 14.5 eV for the dissociative ionization of CF3+, the observed ion efficiency for the CF3+ ion was extremely large the order of 10-20 cm-2, compared with only 10-21 cm-2 for the other channels. PPVE characteristically generated CF3+ as the largest abundant ion are advantageous for use of feedstock gases in plasma etching processes.

Magnetohydrodynamic and Paramagnetic Phenomena in Electrochemistry with Diamagnetic and Ferromagnetic Millielectrodes

NASA Technical Reports Server (NTRS)

Leventis, Nicholas; Dass, Amala

2004-01-01

There are three kinds of body forces operating in electrolytic solutions in the magnetic field: the magnetohydrodynamic force F(sub B) (=i x B), the F(sub delB) force (approximately B(raised dot)gradB) and the F(sub delC) force (approximately |B|(sup 2)gradC). These three forces manifest themselves differently, depending on the experimental conditions. Thus, diamagnetic disc millielectrodes (e.g., Au) with their plane parallel to the flux density of the homogeneous magnetic field of an electromagnet yield convective behavior analogous to that observed with rotating electrodes; that response is controlled by F(sub B). The same electrodes placed in the inhomogeneous field of a strong permanent magnet yield also convective behavior that is controlled by both F(sub B) and F(sub delB). Finally, similarly sized millielectrodes made of permanent magnets (e.g., Au-coated Nd-Fe-B discs) yield diffusion-controlled behavior at conditions where a gold disc electrode shows behavior dominated by density gradient driven natural convection; in this case the predominant forces are both F(sub delB) and F(sub delC). Under open circuit conditions, ferromagnetic (i.e., magnetizable) millielectrodes (Co, Fe, Ni) dipped in corrosive solutions and placed in homogeneous magnetic fields yield mass-transfer phenomena that seem to be controlled by magnetophoresis.

In situ earthworm breeding in orchards significantly improves the growth, quality and yield of papaya (Carica papaya L.)

PubMed Central

Xiang, Huimin; Guo, Lei; Zhao, Benliang

2016-01-01

The aim of this study was to compare the effects of four fertilizer applications—control (C), chemical fertilizer (F), compost (O), and in situ earthworm breeding (E)—on the growth, quality and yield of papaya (Carica papaya L.). In this study, 5 g plant−1 urea (CH4N2O, %N = 46.3%) and 100 g plant−1 microelement fertilizer was applied to each treatment. The fertilizer applications of these four treatments are different from each other. The results showed that the E treatment had the highest growth parameters over the whole growth period. At 127 days after transplantation, the order of plant heights from greatest to smallest was E > F > O > C, and the stem diameters were E > F > O > C, with significant differences between all treatments. Soluble-solid, sugar, vitamin C, and protein content significantly increased in the E treatment. In addition, the total acid and the electrical conductivity of the fruit significantly decreased in the E treatment. Fruit firmness clearly increased in the O treatment, and decreased in the F treatment. The fresh individual fruit weights, fruit numbers, and total yields were greatly improved in the F and E treatments, and the total yield of the E treatment was higher than that in the F treatment. In conclusion, the in situ earthworm breeding treatment performed better than conventional compost and chemical fertilizer treatments. Furthermore, in situ earthworm breeding may be a potential organic fertilizer application in orchards because it not only improves the fruit quality and yield but also reduces the amount of organic wastes from agriculture as a result of the activities of earthworms. PMID:27994969

78 FR 8223 - Proposed Collection; Comment Request for Form 8879-C and Form 8879-I

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Form 8879-C, IRS e-file Signature Authorization for Form 1120, and Form 8879-I, IRS e-file Signature...: IRS e-file Signature Authorization for Form 1120; IRS e-file Signature Authorization for Form 1120-F. OMB Number: 1545-1864. Form Number: 8879-C; 8879-I. Abstract: The Form 8879-C, IRS e-file Signature...

Testing of Fire Fighting Foam.

DTIC Science & Technology

1980-11-01

for Fresh and Sea Water ( MIL - F - 24385 ); -(C) Underwriters Laboratories Inc. S andard for Air Foam Equipment and Liquid Con- centrates (UL162);4D...C. Test Facilities 6 D. Test Procedures 7 III. Results of Tests A. FRN-1007 33 B. MIL - F - 24385 34 C. UL 162 34 D. O- F -555C 35 E. Foam Quality 35 IV...1 gpm) H N-heptane in. inch (25.4 mm = 1 in.) ipm liters per minute M Motor Octane Rating MIL MIL - F - 24385 Test Method NFPA National Fire Protection

Combining Symbolic Computation and Theorem Proving: Some Problems of Ramanujan

DTIC Science & Technology

1994-01-01

1994 CMU-CS--94- 103 ¶ DTIC MAY 0e o99 c -rnepe Combining symbolic computation and theorem proving: some problems of Ramanujan Edmund Clarke Xudong Zhao...Research and Development Center, Aeronautical Systems Division (AFSC), U.S. Air Force, Wright-Patterson AFB, Ohio 45433-6543 under Contract F33615-90- C ...Availability Codes n n = f Avail and Ior7. k= f(k) = _L k~of(nk Dist Special 8. =I f (k + c ) =_k=,+ I f (k) A .[ 3. List of problems The list of challenge

Responses of Cholinergic and Noncholinergic Renshaw Cell Receptors After Acute and Chronic Exposure to Anticholinesterases.

DTIC Science & Technology

1983-07-01

SECURITY CLASSIFICATION OF THIS PAGEMten. Deae Eneered; WILIM . ANMEER . . A .- M P D t JIG3.9) 0D O R E P O S E.O AHL N R M YC A N D I N C L I N I R...ESA C A N S H AWE V E L L E PT O R N AH ANes, Iowa 5A0011 AF ROCTE AD HROIC SEOSRE TAN TIONETES ( U.S. ARY ANNAL RSUARY RN EO NTCMMN Fort Detrick...supramaximal antidromic ventral root stimulation (fig. 23a-f), with less effect on frequency of the discharge. As seen in figure 23 (a,b,c, cf. d, e ,f

Risk Factors for Chorioamnion Infection and Adverse Pregnancy Outcome Among Active-Duty Military women and Dependent Women

DTIC Science & Technology

1998-10-01

0 00 012 IIOTI -- 00 0 Z 0 0 REFERENCES 1. McGann, E. F., Winchester, M. I., Carter, D . P ., Martin, J. N., Jr., Bass, D ., Morrison, J. C. Factors...Women: 1982-1992. 0a014 14. Magann, E. F., Winchester, M. I., Carter, D . P ., Martin, J. N., Jr., Bass, D ., and Morrison, J. C. Factors adversely...D ZHI CE) 10T CD ZC I eC-) 3Z co 00 000 CD CD) z_ < zll CD 1a 1 1 S C) I 1 icD=---I i !! Iz .i 3, z6 z,- !0 D Iz~=3 S--I_ 11001D The current C

Structures and electron affinities of the di-arsenic fluorides As2Fn/As2Fn- (n=1-8).

PubMed

Kasalová, Veronika; Schaefer, Henry F

2005-04-15

Developments in the preparation of new materials for microelectronics are focusing new attention on molecular systems incorporating several arsenic atoms. A systematic investigation of the As2Fn/As2Fn- systems was carried out using Density Functional Theory methods and a DZP++ quality basis set. Global and low-lying local geometric minima and relative energies are discussed and compared. The three types of neutral-anion separations reported in this work are: the adiabatic electron affinity (EAad), the vertical electron affinity (EAvert), and the vertical detachment energy (VDE). Harmonic vibrational frequencies pertaining to the global minimum for each compound are reported. From the first four studied species (As2Fn, n=1-4), all neutral molecules and their anions are shown to be stable with respect to As-As bond breaking. The neutral As2F molecule and its anion are predicted to have Cs symmetry. We find the trans F-As-As-F isomer of C2h symmetry and a pyramidalized vinylidene-like As-As-F2- isomer of Cs symmetry to be the global minima for the As2F2 and As2F2- species, respectively. The lowest lying minima of As2F3 and As2F3- are vinyl radical-like structures F-As-As-F2 of Cs symmetry. The neutral As2F4 global minimum is a trans-bent (like Si2H4) F2-As-As-F2 isomer of C2 symmetry, while its anion is predicted to have an unusual fluorine-bridged (C(1)) structure. The global minima of the neutral As2Fn species, n=5-8, are weakly bound complexes, held together by dipole-dipole interactions. All such structures have the AsFm-AsFn form, where (m,n) is (2,3) for As2F5, (3,3) for As2F6, (4,3) for As2F7), and (5,3) for As2F8. For As2F8 the beautiful pentavalent F4As-AsF4 structure (analogous to the stable AsF5 molecule) lies about 30 kcal/mol above the AsF3 . . . AsF5 complex. The stability of AsF(5) depends crucially on the strong As-F bonds, and replacing one of these with an As-As bond (in F4As-AsF4) has a very negative impact on the molecule's stability. The anions As2Fn-, n=5-8, are shown to be stable with respect to the As-As bond breaking, and we predict that all of them have fluorine-bridged or fluorine-linked structures. The zero-point vibrational energy corrected adiabatic electron affinities are predicted to be 2.28 eV (As2F), 1.95 eV (As2F2), 2.39 eV (As2F3), 1.71 eV (As2F4), 2.72 eV (As2F5), 1.79 eV (As2F6), 5.26 eV (As2F7), and 3.40 eV (As2F8) from the BHLYP method. Vertical detachment energies are rather large, especially for species with fluorine-bridged global minima, having values up to 6.45 eV (As2F7, BHLYP).

Shorter contributions to general geology, 1917

USGS Publications Warehouse

White, David

1918-01-01

A. Baked shale and slag formed by the burning of coal beds / G.S. Rogers B. The Newington moraine, Maine, New Hampshire, and Massachusetts / F.J. Katz and Arthur Keith C.A comparison of Paleozoic sections in southern New Mexico / N.H. Darton D. Wasatch fossils in so-called Fort Union beds of the Powder River Basin, Wyo., and their bearing on the stratigraphy of the region / C.H. Wegemann E. Geologic history indicated by the fossiliferous deposits of the Wilcox group at Meridian, Miss. / E.W. Berry F.A fossil flora from the Frontier formation of southwestern Wyoming / F.H. Knowlton G. The stratigraphic position and faunal associates of the orbitoid Foraminifera of the genus Orthophragmina from Georgia and Florida / C.W. Cooke G. Orbitoid Foraminifera of the genus Orthophragmina from Georgia and Florida / J.A. Cushman H. The Pliocene history of northern and central Mississippi / E.W. Shaw I. Stratigraphy in northwestern Maine and southeastern New Hampshire / F.J. Katz J. The Flaxville gravel and its relation to other terrace gravels of the northern Great Plains / A.J. Collier K. The Helderberg limestone of central Pennsylvania / J.B. Reeside L. Stratigraphy of the Hanna Basin, Wyo. / C.F. Bowen

An Examination of Alternative Forms of Fit in Contingency Theory.

DTIC Science & Technology

1984-11-01

r , ’D 0 0 cc . . Go s 0% %0 ON 0% 1 0 )134 0 0 %0 % 0 0n% 0 co -% 0 𔃺 4: w~ N - N N C C .) C -7 9 0 E .4 0- ’A P- 0 P-o 0IT -%0 0 ( 04 - w0 ’ ~ 0 AP...STRATEOIC - MANAGEMENT RESEARCH CENTER DTIC E L F C 7 f: I lubh rt I I I Itanplirc lofaittatvot I’ubli Att air" ,i apartmn~art t Ag~riutal & Applied...designs of context ( e a MANOVA or regression should result in environment, tecAnology equations on performance lower performance. r size)

Independent Evaluation Plan (IEP) for Sealed Nickel-Cadmium (NICAD) Battery Support.

DTIC Science & Technology

1982-09-07

L C , L .. A C P CC FT N _ C_ V" //ATCD-F A/- T -C !S// / , ....C ALSA/CLA . " A ’ T LEE VA f/ TCL -CFu// RU’ TF H A’/ , C .F r RUCL 4T3/Z DFC .0COM...RUCLEJA/C ZFrUSA*TC FT EU STIS VA / /A TSP-C ’// RUC XU A/ n R U 7A ".1COM R SA A L /ORCPM -H3 S/ OR CIP1- TD I/ X r A𔃽E C2 ?-UWTROA UNCLAS PULJkFUA/C :R

Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy

DTIC Science & Technology

2006-05-01

2005, 7, 493-500. (30) Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E.; Lindahl, T.; Barnes...Cell Biol. 2005, 7, 493–500. 31. Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E

14 CFR 33.93 - Teardown inspection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... completing the endurance testing of § 33.87 (b), (c), (d), (e), or (g) of this part, each engine must be...) After completing the endurance testing of § 33.87(f), each engine must be completely disassembled, and... endurance testing of §§ 33.87 (b), (c), (d), or (e) of this part, and followed by the testing of § 33.87(f...

14 CFR 33.93 - Teardown inspection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... completing the endurance testing of § 33.87 (b), (c), (d), (e), or (g) of this part, each engine must be...) After completing the endurance testing of § 33.87(f), each engine must be completely disassembled, and... endurance testing of §§ 33.87 (b), (c), (d), or (e) of this part, and followed by the testing of § 33.87(f...

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place. Part 3 (E&E Reisen - Hiawatha Rubber Co)

DTIC Science & Technology

1990-01-01

w ui 3j W3A b a w ww w w u i U j L A u a w Wa 4*to a o a N C4 anL (a "Cc cm em an a aD a A a GOO F6 46 404 S. >0 I.J man com 04 R 12 CM e4cc ~ m I...I WC: I co r aCCa 001 I-I 0. 0 NCJ o #1.U0 1-- 44 4 -4W C )C (JN -4~y 001 4 4 1I~ C’I1- mmcoco 44 I I. 4 C . a I- U. >- -4.- 010 00 - 1 . Za -C 4 vm...6W1-6z x. z-z- U~.L 4c -C I.--.4- z~L L W~mm 09~ ac -4- U..CI -I io ACLZ 0 U 3 0 0 (0 62 0 z I. zzz (A 6 000 Csd 314" 6 6 CA (ft 4.WU U . U A F4 F6 I I

Using Tryptophan Mutants To Probe the Structural and Functional Status of BsSCO, a Copper Binding, Cytochrome c Oxidase Assembly Protein from Bacillus subtilis.

PubMed

Hussain, Shina; Andrews, Diann; Hill, Bruce C

2017-12-05

The synthesis of cytochrome c oxidase protein from Bacillus subtilis (i.e., BsSCO) binds copper with picomolar affinity, which increases the protein's melting temperature (i.e., T M ) by 20 °C. Here two native tryptophans (i.e., W36 and W101) are identified as major contributors to BsSCO's structural form, and their contributions to the stability, intrinsic fluorescence, and copper binding properties of BsSCO are explored. Single mutations of tryptophan to phenylalanine decrease the T M by 10 °C and the folding free energy by 3-4 kcal/mol. A more severe change to alanine (i.e., W36A BsSCO) decreases the T M by 20 °C and the stability by 9 kcal/mol. However, these mutants bind copper with high affinity and assemble cytochrome c oxidase in vivo. Replacing phenylalanine at a position near (∼5 Å) the copper binding site with tryptophan (i.e., F42W) increases the T M of apo-BsSCO by 3 °C but diminishes the effect of copper binding. When both native tryptophans are changed to alanine, apo-BsSCO is unfolded in vitro and is not functional in cytochrome c oxidase assembly in vivo. A double-mutant of BsSCO in which W36A is combined with F42W exhibits a form of metastability. Apo-W36A/F42W BsSCO melts at 37 °C, which upon binding of copper shifts to 65 °C. B. subtilis expressing W36A/F42W BsSCO and grown at 37 °C does not assemble cytochrome c oxidase. However, when these cells are cooled to 25 °C, cytochrome c oxidase activity is recovered. Our results illustrate the subtle relationship between the structural stability and functional properties of BsSCO in the assembly of cytochrome c oxidase.

Advanced Motor-Controller Development.

DTIC Science & Technology

1983-06-22

OUTPUTS: 16 BIT PROE:UCT IN ACCA , FiCC:B Oi:t2 -* 0011: 0172 B:7 .04E SIFY STA A MCAN:,* SF,-’E MULTIPLICAND 001t4 0175 iF CLF: A INIT RESUI_I_T AOll5...OL-:t41) 04: ELSE ACCA IS UNC:HANGED 0-142 01SF ::,A 0CI CLAMP 0’Fi A #0 TEST SIGN OF A C0It 0l91 E’E: fBM I C.LIPI EBRFNCH IF NEG 01t4 4 : : 001,15 19...ELSE S.:ET ACCA =-ACCB:1B TQJ5. 01 .’ NEG B .ESTOPE ACCE: 01155 C. l1’-9 E -9 PTI RETUR’N Al? I .9~~ _________ . .... ... | |- - - - . . rjOt :E

Final Remedial Investigation/Baseline Risk Assessment for the Ravines and Beach Area Study of the Surplus Operable Unit, Fort Sheridan, Illinois. Volume 1: RI Text and RI Appendices A-I.

DTIC Science & Technology

1998-04-13

f73o* ^V^^- l^-J&4-g>- «Ajjv»^*^Y gvrg-ft^i Q^r-^vj-eJl -^TVYN ffa 3c 4*> lඑ^=> -£=r~. cgyjv-p f...fvvo H’fefat. l°3> A 13,o — £.3’ fW=> {vfi- ffa ^ os-iC 6 lza/1 *2- r^5^ to/»e(%L C83’ ISTR/METHOD: 8 jPS-g- |17^ I a«, IT N^T K... BBP -Beplieatt MST-bsmmeat

Application of Acoustic Signal Processing Techniques to Seismic Data.

DTIC Science & Technology

1977-06-30

Sr(U So 9RU FEND LOA SUNIT STA PLC3 LOA I STA OLC4 F A FORRE-C ;3f F’RARD I REC9; T9 3ET PAST T-4E E24F LIZE 2 0’ LC3 r ZE 0 PLC4 t~zs 0 FEND STZ 3AKSCN...0)0.4 E 4.1 33 Ŕ. 37.0 12-46-22.9 1?-34-07 .1 M VMiHM ,P1W LJ 31 wEST ER"’ %EDITEPRANFAN AqPA 301 ALBANIA P62 1220 F2 6P 2 2? 243990 al.0 N 20.4 E

Lasers and Optics

DTIC Science & Technology

2013-03-05

AFRL:! ... J ,, 4 DISTRIBUTION A: Approved for public release; distribution is unlimited. • High Average Power Solid-State Lasers • Ceramic Solid...Stanford Romain Gaume – U.C.F. DISTRIBUTION A: Approved for public release; distribution is unlimited. 11 DISTRIBUTION A: Approved for public...Ceramics Robert Byer - Stanford Romain Gaume – U.C.F. 12 0 5 10 15 900 1000 1100 1200 1300 1400 1500 1600 1700 A b s o rp ti o n C o e ff ic e in

Effect of ethanol on the gelation of aqueous solutions of Pluronic F127.

PubMed

Chaibundit, Chiraphon; Ricardo, Nágila M P S; Ricardo, Nádja M P S; Muryn, Christopher A; Madec, Marie-Beatrice; Yeates, Stephen G; Booth, Colin

2010-11-01

In dilute aqueous solution unimers of copolymer F127 (E(98)P(67)E(98)) associate to form micelles, and in more concentrated solution micelles pack to form high-modulus gels. Cosolvents are known to affect these processes, and ethanol/water mixtures have been of particular interest. Dynamic light scattering from dilute solutions was used to confirm micellization, but major attention was directed towards the gels. Visual observation of mobility (tube inversion) was used to detect gel formation, oscillatory rheometry to confirm gel formation and provide values of the elastic moduli over a wide temperature range, and small-angle X-ray scattering to determine gel structure. The solvents were limited to 10, 20 and 30 wt.% ethanol/water. Critical concentrations for gel formation were similar for 10 and 20 wt.% ethanol/water but were significantly increased for 30 wt.% ethanol/water, e.g. at T=45 degrees C from c approximately 15 wt.% to c approximately 28 wt.%. The elastic moduli reached maximum values at T approximately 50 degrees C: e.g. G' approximately 25 kPa for 25 wt.% F127 in 10 and 20 wt.% ethanol/water and a similar value for 30 wt.% F127 in 30 wt.% ethanol/water. Hard gels of 30 and 35 wt.% F127 in ethanol/water at 25 and 40 degrees C had the body-centered cubic (bcc) structure. Copyright 2010 Elsevier Inc. All rights reserved.

The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: cloning, production, and purification of active enzymes.

PubMed

Azzolina, B A; Yuan, X; Anderson, M S; El-Sherbeini, M

2001-04-01

We have cloned the Pseudomonas aeruginosa cell wall biosynthesis and cell division gene cluster that corresponds to the mra operon in the 2-min region of the Escherichia coli chromosome. The organization of the two chromosomal regions in P. aeruginosa and E. coli is remarkably similar with the following gene order: pbp3/pbpB, murE, murF, mraY, murD, ftsW, murG, murC, ddlB, ftsQ, ftsA, ftsZ, and envA/LpxC. All of the above P. aeruginosa genes are transcribed from the same strand of DNA with very small, if any, intragenic regions, indicating that these genes may constitute a single operon. All five amino acid ligases, MurC, MurD, MurE, MurF, and DdlB, in addition to MurG and MraY were cloned in expression vectors. The four recombinant P. aeruginosa Mur ligases, MurC, MurD, MurE, and MurF were overproduced in E. coli and purified as active enzymes. Copyright 2001 Academic Press.

Synthesis and Structural Characterization of New High-Valent Inorganic Fluorine Compounds and their Oxidizing Properties. Volume 3

DTIC Science & Technology

1992-02-01

COMPOUNDS AND T•EIR OXIDIZING PROPERTIES: VOLUME 3. Prof. G.J. Schrobilgen DTI.DTIC_* Mc Mastf-• University f ELECTE Department of Chemistry JUN 16...STRUCTURAL CHARACTERIZATION OF NEW HIGH- C - F49620-87-C-0049 VALENT INORGANIC FLUORINE COMPOUNDS AND THEIR OXIDIZING PR- 5730 PROPERTIES TA- 007C S6...fluorine, oxidizers of Neon, Krypton. Argon, and Xenon have been synthesized and characterized. KrF+ and ),eF+ caticmns have been made with neutral

Genetics Home Reference: short QT syndrome

MedlinePlus

... on PubMed Central Gaita F, Giustetto C, Bianchi F, Wolpert C, Schimpf R, Riccardi R, Grossi S, Richiardi E, Borggrefe M. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003 Aug 26;108(8):965-70. Epub 2003 ... P, Dalmasso P, Borggrefe M, Gaita F. Long-term follow-up of patients with short ...

Word Frequency Analysis. MOS: 51C. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

FF-TCR1NG I RESTS 2 RESULT I RESJLTS I VETA I NS 3 it 0Up N I R~vERS-1L. I F E VtS ZNG I PEVELVIKG MOS WORDo LISTINGASCENDIIG SECUEME C.ATE 93259 t39...1 0 J CACCUPULATEG 1 J fiCID I * ?L4CoS 1 j & T.CrC$S 2 0 J tAnJUSTASLE I J rC.Ff ER 8 J E .11:-COflOITIOING 5 *J CALL 1 0 J LALLOM I J (A~LLOW~S 4 *J...ALCMj 3 *J &:.L" VS 1 0 3 12 0 j ...’Jo I *J W Git Z I ., 1 4 J fNVIL I ’ . lUV I J E C.PPEAJRS I I J E .*,PL! CATION 2 2 C. PPLY I 3 C.;PPPtovEo a 3

Knowledge Based Concepts and Artificial Intelligence: Applications to Guidance and Control.

DTIC Science & Technology

1987-08-01

S tC* I it t r,, h syste t reason bout te aa lbe t m orsm l Ai, , eptW*- iip - Iil" n tI , and the n ob ain th "est s lut on co sis en wih ht a~a la ...f CE C- flEcflCE co0 m E ’?- MCD.- CD . -V E .UEE M4)c > 1 1 > * EO- EN >’? CI-E ’k EC Cw 0?0 0C O C -5? M’ D- W La LEE JOC -EE) C LEV . 3 -C 3LE3UmV...while he is, troublehoomig the circuit I)F-)AI I is a winking proiotrrlt’ Iha will be esreided \\,i hln the IMR( -\\l I icril S,,csln- ctlop ilnt en

The STRONG STAR Multidisciplinary PTSD Research Consortium

DTIC Science & Technology

2012-09-01

used to determine GR levels. The A450 values for each t h d a a b t ( T g b a c c u r p c i e t s e a c F C b l p r p C r a a i M. K. Green et al...Neuropsychology 9:118–125. Valle M, Mayo W, Dellu F, Moal ML, Simon H, Maccari S (1997) Prenatal stress induces high anxiety and postnatal handling in- duces...June 2012 Accepted 16 July 2012 Keywords: PTSD Stress Coping style Anxiety HPA-axis a b s t r a c t Exposure to psychological

Final Environmental Assessment/Overseas Environmental Assessment Joint Strile Fighter System Development and Demonstration Developmental Test Program

DTIC Science & Technology

2007-01-01

tte r t es t a...ct iv iti es . Pr op os ed p er fo rm an ce te st s w ou ld c oi nc id e w ith F Q , f lu tte r, hi gh A ng le -o f- A tta ck ( A oA ), an...cl os el y in te gr at ed w ith th e FQ , f lu tte r, an d hi gh A oA te st s a nd w ou ld g en er al ly p ro ce ed in c on ce rt

24 CFR 16.15 - Specific exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

...), (e)(1), (e)(4) (G), (H), (I), and (f). This exemption allows the Department to withhold records... under 5 U.S.C. 552(k)(5) from the requirements of 5 U.S.C. 552a (c)(3), (d), (e)(1), (e)(4), (G), (H... subsection (e)(1) because it is often impossible to determine relevance or necessity of information in pre...

Pressures on DoD’s Budget Over the Next Decade

DTIC Science & Technology

2016-11-16

Congressional Budget Office Pressures on DoD’s Budget Over the Next Decade Presentation at the Professional Services Council 2016 Vision Federal...E Outline • Fiscal Situation • Implications of Budget Control Act • Internal Pressures on DoD’s Budget 2C O N G R E S S I O N A L B U D G E T O F F...I C E Deficits or Surpluses Under CBO’s Baseline for FY 2016 CBO’s Baseline Projection Source: Congressional Budget Office, An Update to the

Systems Defense Games: Colonel Blotto, Command and Control

DTIC Science & Technology

1978-03-30

problems.* 2. SYST ~~EAS ? FRAI.217- E AX,, 2Z1E C4AE:7T :~C~ At. n-person game in coalitional form is described by a chara•ý•,r- i.s•;. fzr..’icn v...be described es (1) €,: - I-7 S b P l. .’[:, j ,- , S I Consider the 3-person game with a characteristic function as follows* Shapley (1959). e *The... game . Specifically, assume that t& e same outcome function f(-,’) de- scribes thesituationatall n targets (battlefields), and further assume that f Is

Transformation of arachidonate into 6-oxoprostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 by sheep lung microsomal fraction.

PubMed Central

Tai, H H; Yuan, B; Wu, A T

1978-01-01

In the presence of haemoglobin and isoproterenol, the microsomal fraction of sheep lung catalysed the conversion of arachidonate predominantly into thromboxane B2 and to a lesser extent into 6-oxoprostaglandin F1alpha. Very little prostaglandin E2 and prostaglandin F2alpha were formed. If reduced glutathione was added in combination with haemoglobin and isoproterenol, the synthesis of prostaglandin E2 was favoured over that of thromboxane B2 and 6-oxoprostaglandin F1alpha. The identities of these products were confirmed by t.l.c. and by combined g.l.c.-mass spectrometry. These results indicate that microsomal fraction of sheep lung possesses active prostaglandin synthase, prostacyclin synthase and thromboxane synthase activities. PMID:637853

TAP II Beamforming System Software Final Report

DTIC Science & Technology

1977-05-01

3.0 IBM TAPE FORMATS......... ............. -1 • 3 . 2 C om p le x C o e f f ic i e n t 8 . *.. . o t... . . . . . . .. . . . . . . . 3 - 5 :i • 3.3...parameters. Output to the line - printer and CRT are inhibited, but the IBM tapes are written. d Li UNCLASSIFIED CONFIDENTIALI A2 2.5 (C) EDITING (U...t• •• ", .. . .. . ..•" ;"• :, • .••.•-. ~ ., ~ ,., ,~.’ " ’t••. •± CONFIDENTIAL LI 3.0 (C) IBM TAPE FORMATS (U) .B 3.1 (U) GENERAL

Dynamics of Radiation and Atoms in Ultrahigh Intensity Laser Fields

DTIC Science & Technology

2013-12-31

Rob Mitchell, N. Ekanayake, A. Watts, S. White , Rob Sauer, L. Howard, M. Videtto, C. Mancuso, S. Wells, T. Stanev, B. Wen, M. Decamp, B. Walker, Sasi...Chen, Z. Bond, A. Loether, L. E. Howard, Y. Gao, S. LeMar, S. White , A. Watts, B. C. Walker, M. F. DeCamp. Reconstructing longitudinal strain pulses...Ekanayake, A.M. Watts, S.L. White , Rob Sauer, L.E. Howard, M. Videtto, C. Mancuso, S.J. Wells, T. Stanev, B.L. Wen, M.F. Decamp, and B.C. Walker. Ionization

National Dam Safety Program. Jacksons Pond Dam (NJ00771), Arthurkill River Basin, Rahway River, Union County, New Jersey. Phase I Inspection Report.

DTIC Science & Technology

1981-08-01

previouuly mentioned, bedrock in the area consists of red shale and sandstone of Triassic age . -2 SI 1.3 Pertinent Data a. Drainage Area 40 square miles b...COyP rFEONII NowTO \\ ASCU ~T - .LA1LP1?, F NAINLPOGA FISPCINO NNFDDM ~coeiEI laic- it leF~IN Ipo l ii m8I,_ -QA I EV APPENDIX 1 CHECK LIST VISUAL...a r.f ,i 13 14 TS C910C. 41,0-1 S70~ m f"", S C~ tec,( (Caed 3 /e-a2~V ’U0 16 r67 (k~otc ,yrude iVLAOti & L1Away k I 3 eř A.A 17 19 Or(CL age

Host control of plasmid replication: requirement for the sigma factor sigma 32 in transcription of mini-F replication initiator gene.

PubMed Central

Wada, C; Imai, M; Yura, T

1987-01-01

Replication of F factor or mini-F plasmid is strongly inhibited in the rpoH (htpR) mutants of Escherichia coli deficient in the sigma factor (sigma 32) known to be required for heat shock gene expression. Transcription of the mini-F repE gene encoding a replication initiator protein (E protein) was examined by operon fusion and by direct determination of repE mRNA. The synthesis rate and the level of repE mRNA were found to increase transiently upon temperature upshift (30 degrees C to 42 degrees C) in wild-type cells but to decrease rapidly in the rpoH mutants. Thus sigma 32 appeared to be directly involved in transcription of repE whose product, E protein, in turn activates DNA replication from the mini-F ori2 region. This scheme of host-controlled plasmid replication is further supported by the analysis of transcription in vitro: RNA synthesis can be initiated from the repE promoter by a minor form of RNA polymerase containing sigma 32 but not by the major polymerase containing the normal sigma factor sigma 70. The sigma 32-mediated transcription from the repE promoter is strongly inhibited by the E protein. We conclude that transcription of the mini-F repE gene is mediated by the host transcription factor sigma 32 and is negatively controlled by its own product. Images PMID:2447584

RPSL1D (A One-Dimensional Version of REPSIL).

DTIC Science & Technology

1982-11-01

PROGRAM FOR RPSL1D ....... ..................... 97 E . EXAMPLES ........... ............................ .105 F. SOME ALTERNATE USER SUBROUTINES...of these have been incorporated into RPSLID, as tabu- lated in Appendix C, and others discussed in Section 5 and Appendices E and F may be useful in...replace them with copies of user subroutines listed in Appendices E and F, or replace them with his own subroutines. For some particular applications it

Three-Dimensional Propagation and Scattering Around a Conical Seamount

DTIC Science & Technology

2007-06-01

s) Td . I or, 71 IT +~ f E [ai’D+l + 153j n 1JDJ+Iil (rj) r7 1 ql(Z)Xpij+l[, = ZL ,i2nH1., (,)+ 1, ,, )1 k --f , 1(z) Mll qjk)I,p4z)d1. (4.45) 102...F,t )-I (DH-ljC,,,+’. flj + Ihj ,Cb+’DfIIlj ) f + (Fj) -’ (DIlh,,C a+ lj 7’+1 -, !/,.-fI/’jiC+1lDjJ I) b-’,,+ REJ+ 1 anj+ 1 + Jl R3r, ’ 1,(4|.55...80 , li ,c൓ 400 400 ; :l 200 I/10 0 0 200 -400 -400 -00fO d00 50 50 (a) Td Los, dg) C-SNAP J 0 7 - os s (M), C-SNAP Jx 33 12012 600 110 600 110 400

20 CFR 903.8 - Exemptions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... records only where appropriate from the following provisions: sections (c)(3); (d); (e)(1); (e)(4)(G), (e)(4)(H), and (e)(4)(I); and (f) of 5 U.S.C. 552a. (c) Reasons for claimed exemptions: (1) The Privacy Act of 1974 creates several methods by which individuals may learn of and obtain records containing...

Electro-Spark Deposited Coatings for Replacement of Chrome Electroplating

DTIC Science & Technology

2005-06-01

2.6 0.4 2.2 Thickness uniformity (A-F) 2.8/0.8 2.8/0.8 6.3/0 6.5/0.4 2 to 0 3.9/0.4 Coating integrity (A-F) A A- F C - D A- Defects/mm F D + F D + F B...or width of the wear scar (cm), h is the height or depth of the wear scar (cm), and c is the circumference of the wear scar (cm) where c = "rrd, and d ...inerS4C *2 Panelb MHC583010 -,,IN 3 4853 0.42 roiness 1)N32-15m x c -e sca. 3) &wN x Deb 1nQ withn sar Dein HxW 1).057n*~ 3)211200 12 ve 2 Panl 2 EJC .5 D

Fuel Property Effects on Diesel Engine and Gas Turbine Combustor Performance.

DTIC Science & Technology

1981-11-01

REPORT AFLRL No. 149 By A.F. Montemayor D.W. Naegeli -* L.G. Dodge E.C. Owens J.N. Bowden U.S. Army Fuels and Lubricants Research Laboratory Southwest...6800-120/ 1 7 AUTHOR18) S. CONTRACT ORt GRANT NUMBER(a) A.F. Vmotemeyor E. C. Owens DMA7-8O-C-0001 D. W. Naegeli J.N. Bowden DAAK70-82-C-OOO1 L.G...Acquisition Magazine, 18-20, September-October 1980. 5. Noses, C.A. and Naegeli , D.W., "Fuel Property Effects on Combustor Performance," ASME 79-GT-178

Report of the Defense Science Board Task Force on Year 2000.

DTIC Science & Technology

1998-04-01

Reagan 11:45 ASD (C3I) Mr. Tony Valletta , Acting ASDfC3!) 12:15 Lunch 12:45 Patriot Mr. Dean Mullis 1:45 F-15E Col Richard Bowman, F-15 Program...Financial Operations, Logistics, Transportation Adjourn Mr. Tony Valletta , Acting ASDfC31) Mr. Tom Backman Mr. Jack Winters Col Rounce and Maj...Coffee/ Tea 8:30 Chairman’s time 9:00 Task Force Discussions 10:15 C3I Update Tony Valletta , Actg. ASDfC3!) 11:00 J-6V 11:45 Lunch 12:15 Navy E

Model Selection and Accounting for Model Uncertainty in Graphical Models Using OCCAM’s Window

DTIC Science & Technology

1991-07-22

mental work; C, strenuous physical work; D, systolic blood pressure: E. ratio of 13 and Qt proteins; F, family anamnesis of coronary heart disease...of F, family anamnesis . The models are shown in Figure 4. 12 Table 1: Risk factors for Coronary lfeart Disea:W B No Yes A No Yes No Yes F E D C...a link from smoking (A) to systolic blood pressure (D). There is decisive evidence in favour of the marginal independence of family anamnesis of

Substituent Effects In a Series of 1,7-C60(RF)2 Compounds (RF = CF3, C2F5, n-C3F7, i-C3F7, n-C4F9, s-C4F9, n-C8F17): Electron Affinities, Reduction Potentials, and E(LUMO) Values Are Not Always Correlated

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuvychko, Igor V.; Whitaker, James B.; Larson, Bryon W.

Substituent effects are of paramount importance in virtually all fields of fundamental and applied chemistry. Classical and modern examples can be found in organic chemistry (Hammett parameters and Charton steric parameters), inorganic chemistry (trans effect and trans influence), organometallic chemistry (phosphine cone angles), physical chemistry (linear free energy relationships and DFT), biochemistry (protein tertiary structure), medicinal chemistry (SAR maps and BioMAP analysis), polymer chemistry (nonlinear optical and permeation properties and glass transition temperatures), and materials chemistry (stability and luminescent properties of electroluminescent devices and light-to-power conversion efficiencies of fullerene-derivative-based OPV devices).

Changes of blood levels of several hormones, catecholamines, prostaglandins, electrolytes and cAMP in man during emotional stress.

PubMed

Tigranian, R A; Orloff, L L; Kalita, N F; Davydova, N A; Pavlova, E A

1980-01-01

The levels of several hormones (ACTH, GH, TSH, FSH, LH, parathyroid hormone--PTH, insulin, thyroxine--T4, triiodothyronine--T3, cortisol, testosterone, aldosterone, renin), catecholamines (epinephrine, norepinephrine, dopamin), prostaglandins (F1 alpha, F2 alpha, A + E), electrolytes (Na, K, Ca, Mg), cAMP and glucose in blood were measured before and immediately after the examination in 15 male students aged 28 to 35 years. Simultaneously the blood pressure was measured and hemodynamic measures were registered with the aid of echocardiography. A remarkable increase of catecholamines, ACTH, renin, T3, PTH, cAMP, PG F1 alpha, PG F2 alpha and Ca was found before the examination together with the increase of blood pressure. After the examination the levels of catecholamines, renin, aldosterone, T3, PTH, GH, FSH, LH, testosterone, PG A + E, glucose and Ca were found to be increased, while these of insulin, Na, PG F1 alpha, PG F2 alpha were decreased. The decrease of blood pressure was also found.

Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging.

PubMed

Leyton, Julius; Lockley, Michelle; Aerts, Joeri L; Baird, Sarah K; Aboagye, Eric O; Lemoine, Nicholas R; McNeish, Iain A

2006-09-15

The adenoviral E1A CR2 mutant dl922-947 has potent activity in ovarian cancer. We have used Renilla luciferase bioluminescence imaging to monitor viral E1A expression and replication and [18F]fluorothymidine positron emission tomography ([18F]FLT-PET) to quantify the activity of dl922-947 in vivo. We created dlCR2 Ren, with the same E1A CR2 deletion as dl922-947 and the luciferase gene from Renilla reniformis downstream of E1. Light emitted from s.c. and i.p. IGROV1 ovarian carcinoma xenografts was measured following treatment with dlCR2 Ren. Mice bearing s.c. IGROV1 xenografts were injected with 2.96 to 3.7 MBq of [18F]FLT 48 and 168 hours following i.t. injection of dl922-947 or control virus Ad LM-X. The presence of Renilla luciferase in dlCR2 Ren did not reduce in vitro nor in vivo potency compared with dl922-947. Light emission correlated closely with E1A expression in vitro and peaked 48 hours after dlCR2 Ren injection in both s.c. and i.p. IGROV1 xenografts. It diminished by 168 hours in s.c. tumors but persisted for at least 2 weeks in i.p. models. Normalized tumor [18F]FLT uptake at 60 minutes (NUV60), fractional retention, and area under radioactivity curve all decreased marginally 48 hours after dl922-947 treatment and significantly at 168 hours compared with controls. There was a close linear correlation between NUV60 and both tumor proliferation (Ki67 labeling index) and thymidine kinase 1 expression. Renilla luciferase bioluminescence and [18F]FLT-PET imaging are capable of quantifying the activity and effectiveness of E1A CR2-deleted adenoviral mutants in ovarian cancer.

Cancer Localization in the Prostate with F-18 Fluorocholine Position Emission Tomography

DTIC Science & Technology

2008-01-01

R , Ward E, Murray T , Xu J, Thun MJ. Cancer statistics, 2007. CA...2007. 8 C C S F I l p m p t f a i l z i m m * † ‡ § S A 4 ancer Imaging With Fluorine-18–Labeled holine Derivatives andi A. Kwee, MD,*,† Timothy R ...prostate cancer imaging. v i s f b t r h i K n u f t B l t i m i F s i b a d i s w l l o t c p P i p w t h d p 422 S.A. Kwee

Evaluation of the Defense Agencies Law Enforcement Divisions Compliance with the Lautenberg Amendment Requirements and Implementing Guidance

DTIC Science & Technology

2016-02-23

Coverage During the last 5 years, the DoD Inspector General (IG) issued one report discussing the Lautenberg Amendment . Unrestricted DoD IG reports can be...Enforcement Divisions’ Compliance with the Lautenberg Amendment Requirements and Implementing Guidance I N T E G R I T Y  E F F I C I E N C Y...Evaluation of the Defense Agencies’ Law Enforcement Divisions’ Compliance with the Lautenberg Amendment Requirements and Implementing Guidance February 23

Polymer Engineering: Polymeric and Molecular Electronic, Dielectric and Optical Properties for Device Applications,

DTIC Science & Technology

1985-01-01

Lida ii v n I has(-* two decenerat-k:<ite ’riAJ uts lctrical codcto canan ’ 111 ’ l f organics ’w’ith rinci er jfrnp 1m sate The mca I isc diopant...mtma eim letona ta 3-ari ant i II eUl c ain g- -o,- sipstifIir~atE * ’ ivan :’ ftI~ivme ad) lifolen in2~fitif tot-- devie /ffla .flalf f.(cC rea i:-i

Service Academy 2006 Gender Relations Survey: Administration, Datasets, and Codebook

DTIC Science & Technology

2006-07-01

you without your consent Someone repeatedly showed you pornographic materials, even after you asked him/her not to Considered neither sexual...consent? 1 2 3 4 c. Someone repeatedly showed you pornographic materials, even after you asked him/her not to? 1 2 3...SC006C 6c. Know- Pornographic materials SC006D 6d. Know-Rumors about your sex beh Know-Little drunk, forced sex SC006E 6e. SC006F 6f. Know-Ruin

Deriving Link Travel-Time Distributions via Stochastic Speed Processes

DTIC Science & Technology

2004-02-01

general, an exact expression for the inverse transform is available when Equation (9) is a vector of rational functions in both of the complex variables...Otherwise, recovery of the original function is accom- plished through the inverse transform f t= 1 2(j ∫ c+j c−j estf ∗s ds (13) which is usually...given by f x t = f ∗s1 s2 = ∫ 0 ∫ 0 e−s1x+s2tf x t dx dt (14) with inverse transform f x t = 1 4(2 ∫ c1+j c1−j ∫ c2+j c2−j e

Assessment of Chemical Solution Synthesis and Properties of Gd2Zr2O7 Thin Films as Buffer Layers for Second-Generation High-Temperature Superconductor Wires (Postprint)

DTIC Science & Technology

2012-02-01

AC05-00OR22725. REFERENCES 1. D.P. Norton, A. Goyal, J.D. Budai, D.K. Christen, D.M. Kroeger, E.D. Specht , Q. He, B. Saffian, M. Paranthaman, C.E...critical current density. Science 274, 755 (1996). 2. A. Goyal, D.P. Norton, J.D. Budai, M. Paranthaman, E.D. Specht , D.M. Kroeger, D.K. Christen, Q...D.K. Christen, M. Paranthaman, E.D. Specht , J.D. Budai, Q. He, B. Saffian, F.A. List, D.F. Lee, E. Hatfield, P.M. Martin, C.E. Klabunde, J. Mathis

C_7F_16/He rf plasma CVD of a-C:F films

NASA Astrophysics Data System (ADS)

Hokoi, Kohji; Akazawa, Masamichi; Sugawara, Hirotake; Sakai, Yosuke

2000-10-01

Fluorinated carbon is one of the most promissing materials with low dielectric constant ɛr and high dielectric strength V_b. We have deposited a-C:F films by rf (13.56 MHz) plasma enhanced CVD method using the following liquid materials; C_7F_16, (C_3F_7)_3N/(C_4F_9)_3N and C_8F_18/C_8F_16O.(C. P. Lungu et al.), Jpn. J. Appl. Phys. 38, L1544--6 (1999) The films showed ɛr values in a range of 1.9--3.0 and V_b>2 MV/cm. In this work, we added He (3 Pa) to C_7F_16 (60 Pa) plasmas, expecting that He atoms in the metastable excited state (He*, 19.8 eV) would promote C_7F_16 decomposition in gas phase or activation of the film surface during deposition. The films with the thickness up to 2300 nm were deposited on unheated Si substrate with an rf power of 100 W. The deposition rate derived from the film thickness measurement by SEM and ellipsometry was about 230 nm/min. This value is roughly two times as large as that of the films deposited by C_7F_16 (60 Pa) plasmas without He. We discuss the mechanism that leads to such a significant increase in the deposition rate.

In-Situ Approach to Introduce Flux Pinning in YBCO (Postprint)

DTIC Science & Technology

2012-02-01

Malozemoff, N. Nguyen, E. Siegal, D. Buczek, J. Lynch, J. Scudiere, M. Rupich, A. Goyal, E.D. Specht , P. Martin, and M. Paranthaman, Supercond. Sci...Peterson, L. Stan, and L.A. Emmert, Physica C. 382,43-47 (2002). [10] A. Goyal, D.F. Lee, F.A. List, E.D. Specht , R. Feenstra, M. Paranthaman, X. Cui, S.W...Gapud, M. Varela, M. Paranthaman, A. 0. Ijaduola, E.D. Specht , J.R. Thompson, O.K. Christen, S.J. Pennycook, and F.A. List, Supercond. Sci. Techno

MILES Pressure/Seismic Response Engineering Development of MILES Test Fixture.

DTIC Science & Technology

1980-08-01

A t ditioti td t’,i o, ,,[ ’ or 44 : t 󈧗’) .0 4 ::: r-C Irr 419: 0,11 5 E+ I-E Mrl;A D ATA FAE’SUL 420: t’:r = I t,. 444: t =t tt1l N # ’’ f t o...3 17 T PA II C E R. TD ES T 58: 2 ;.rt . PI’ MERSUFEP! F112: A.ILE70 ,""",蘇_-244 EtIT": 113: [e 47it -𔄁 t+ 13 -.7!1 end 5’?: l+ " ’:;.,r...34calculate "TRANSPOSI TIOS distonce bet.ee 455: for C.=1 to ’ 4t tde n transposition T-2 416: test defe s = td deviation 456: if abs(L[C+ 4ts":477: if E

Identification and expression of an allergen Asp f 13 from Aspergillus fumigatus and epitope mapping using human IgE antibodies and rabbit polyclonal antibodies.

PubMed Central

Chow, L P; Liu, S L; Yu, C J; Liao, H K; Tsai, J J; Tang, T K

2000-01-01

The Aspergillus genus of fungi is known to be one of the most prevalent aeroallergens. On two-dimensional immunoblotting using patients' sera containing IgE specific for Asp f 13, an allergen with a molecular mass of 33 kDa and a pI of 6.2 was identified. This allergen was also present in A. fumigatus culture filtrates. Furthermore, the sequence of the Asp f 13 cDNA was identical to that for alkaline protease isolated from A. fumigatus and showed 42-49% identity of amino acids with two proteases from P. cyclopium and T. album and with the Pen c 1 allergen from P. citrinum. Asp f 13 coding sequences were expressed in Escherichia coli as a [His](6)-tagged fusion protein which was purified by Ni(2+)-chelate affinity chromatography. Recombinant Asp f 13 was recognized by rabbit polyclonal antibodies against Asp f 13 and by IgE antibodies from subject allergic to A. fumigatus. To identify and characterize the linear epitopes of this allergen, a combination of chemical and enzymatic cleavage and immunoblotting techniques, with subsequent N-terminal sequencing and mass spectrometry, were performed. At least 13 different linear epitopes reacting with the rabbit anti-Asp f 13 antiserum were identified, located throughout the entire molecule. In contrast, IgE from A. fumigatus-sensitive patients bound to three immunodominant epitopes at the C-terminal of the protein. PMID:10677362

U.S. EPA, Pesticide Product Label, UNICORN MULTI-PURPOSE HOUSE & GARDEN INSECT KILLER, 11/06/1996

EPA Pesticide Factsheets

2011-04-21

) f=;:==U~'S~'~O~~~:~i~~~~O~~~f;l~p~~·~~e~i~~~~~e~~; r~~0J~~ams~At~G;:~cY~q==3==-1~::'~ fD ...

Thermodynamics of Supercooled and Glassy Water

NASA Astrophysics Data System (ADS)

Debenedetti, Pablo G.

1998-03-01

The behavior of metastable water at low temperatures is unusual. The isothermal compressibility, the isobaric heat capacity, and the magnitude of the thermal expansion coefficient increase sharply upon supercooling, and structural relaxation becomes extremely sluggish at temperatures far above the glass transition(Angell, C.A., Annu. Rev. Phys. Chem., 34, 593, 1983)(Debenedetti, P.G., Metastable Liquids. Concepts and Principles, Princeton University Press, 1996). Water has two distinct glassy phases, low- and high-density amorphous ice (LDA, HDA). The transition between LDA and HDA is accompanied by sharp volume and enthalpy changes, and appears to be first-order(Mishima, O., L.D.Calvert, and E. Whalley, Nature, 314, 76, 1985)(Mishima, O., J. Chem. Phys., 100, 5910, 1994). The understanding of these observations in terms of an underlying global phase behavior remains incomplete(Speedy, R.J., J. Phys. Chem., 86, 982, 1982)(Poole, P.H., F. Sciortino, U. Essman, and H.E. Stanley, Nature, 360, 324, 1992)(Sastry, S., P.G. Debenedetti, F. Sciortino, and H.E. Stanley, Phys. Rev. E, 53, 6144, 1996)(Tanaka, H., Nature, 380, 328, 1996)(Xie, Y., K.F. Ludwig, G. Morales, D.E. Hare, and C.M. Sorensen, Phys. Rev. Lett., 71, 2050, 1993). Microscopic theories and computer simulations suggest several scenarios that can reproduce some experimental observations. Interesting and novel ideas have resulted from this body of theoretical work, such as the possibility of liquid-liquid immiscibility in a pure substance(Poole, P.H., F.Sciortino, T.Grande, H.E. Stanley, and C.A. Angell, Phys. Rev. Lett., 73, 1632, 1994)(Roberts, C.J., and P.G. Debenedetti, J. Chem. Phys., 105, 658, 1996)(Roberts, C.J., P.G. Debenedetti, and A.Z. Panagiotopoulos, Phys. Rev. Lett., 77, 4386, 1996)(Harrington, S., R. Zhang, P.H. Poole, F. Sciortino, and H.E. Stanley, Phys. Rev. Lett., 78, 2409, 1997). In this talk I will review the experimental facts, discuss their theoretical interpretation, and identify key unanswered questions.

The Effect of Comparatively-Framed versus Similarity-Framed E-Cigarette and Snus Print Ads on Young Adults’ Ad and Product Perceptions

PubMed Central

Banerjee, Smita C.; Greene, Kathryn; Li, Yuelin; Ostroff, Jamie S.

2016-01-01

Objectives This study examined the effects of comparative-framing [C-F; ads highlighting differences between the advertised product and conventional cigarettes and/or smokeless tobacco products] versus similarity-framing (S-F; ads highlighting congruence with conventional cigarettes and/or smokeless tobacco products) in e-cigarette and snus ads on young adult smokers’ and non-smokers’ ad- and product-related perceptions. Methods One thousand fifty one (1,051) young adults (18–24 years; 76% women; 50% smokers) from existing consumer panels were recruited in a within-subjects quasi-experiment. Each participant viewed 4 online advertisements, varied by tobacco product type (e-cigarette or snus) and ad framing (C-F or S-F). The dependent measures for this study were ad-related (ad perceptions, ad credibility) and product-related perceptions (absolute and comparative risk perceptions, product appeal, and product use intentions). Results Former and current smokers rated C-F ads as more persuasive than S-F ads, as evidenced by favorable ad perceptions and high product use intentions. Former and current smokers also rated e-cigarette ads with more favorable ad perceptions, low absolute and comparative risk perceptions, high product appeal, and high product use intentions as compared to snus ads. However, the effect sizes of the significant differences are less than.2, indicating small magnitude of difference between the study variables. Conclusions Unless FDA regulates e-cig and snus advertising, there is a potential of decreasing risk perceptions and increasing use of e-cigs among young adults. Further research on implicit/explicit comparative claims in e-cigarettes and snus advertisements that encourage risk misperceptions is recommended. PMID:28042597

The Effect of Comparatively-Framed versus Similarity-Framed E-Cigarette and Snus Print Ads on Young Adults' Ad and Product Perceptions.

PubMed

Banerjee, Smita C; Greene, Kathryn; Li, Yuelin; Ostroff, Jamie S

2016-07-01

This study examined the effects of comparative-framing [C-F; ads highlighting differences between the advertised product and conventional cigarettes and/or smokeless tobacco products] versus similarity-framing (S-F; ads highlighting congruence with conventional cigarettes and/or smokeless tobacco products) in e-cigarette and snus ads on young adult smokers' and non-smokers' ad- and product-related perceptions. One thousand fifty one (1,051) young adults (18-24 years; 76% women; 50% smokers) from existing consumer panels were recruited in a within-subjects quasi-experiment. Each participant viewed 4 online advertisements, varied by tobacco product type (e-cigarette or snus) and ad framing (C-F or S-F). The dependent measures for this study were ad-related (ad perceptions, ad credibility) and product-related perceptions (absolute and comparative risk perceptions, product appeal, and product use intentions). Former and current smokers rated C-F ads as more persuasive than S-F ads, as evidenced by favorable ad perceptions and high product use intentions. Former and current smokers also rated e-cigarette ads with more favorable ad perceptions, low absolute and comparative risk perceptions, high product appeal, and high product use intentions as compared to snus ads. However, the effect sizes of the significant differences are less than.2, indicating small magnitude of difference between the study variables. Unless FDA regulates e-cig and snus advertising, there is a potential of decreasing risk perceptions and increasing use of e-cigs among young adults. Further research on implicit/explicit comparative claims in e-cigarettes and snus advertisements that encourage risk misperceptions is recommended.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 16. (Robert E. Rivera Const. Co.-Singapore Aircraft Industries)

DTIC Science & Technology

1989-01-01

E 0 , f- ~ - el 2.0 >f ~~.- 0 V?0 ) *-’Q) Q: Z 10 1Z o Oc 4V cc o S7 - L E) o 0 0 a) .97 -L ) U c c r_ In CL M) E2 -4 CL W) > V a) C. L- L. - C V...4 -140)(m0)) 00000000000000000 ))))))))))))))) 11 a)1 W-4N,41 I N -IN m Go00 0000* 400000000000000000000000O0000000 II El W-40 1102 42 02222Z...34 :: mmmmmmimmcl3mmmmmmmm m commmmm U-4 zzzzzzzzzzzzzzzzz z zzzzzz M-4c,)O:: in m in m m o 0 0 In In In In In In In on In In U") In In en CY) U) In W W) 9) U"I M-4" " C14

Staffing Cyber Operations (Briefing Charts)

DTIC Science & Technology

2015-05-01

Ti tle 1 0 m is si on s  N o tim e to b ui ld th is re qu ire m en t i n th e P O M – R eq ui re m...o r f ro m a co or di na te d m ili ta ry o pe ra tio n of w hi ch th at a ct c on st itu te s an in te gr al p ar t  B el lig er en t...U se d C A P E F C oM To ol ; a dj us te d so m e fa ct or s  S ub st itu

Service Members in School: Military Veterans’ Experiences Using the Post-9/11 GI Bill and Pursuing Postsecondary Education

DTIC Science & Technology

2010-11-01

for Education, for the American Council on Education S E R V I C E M E M B E R S I N S C H O O L Military Veterans’ Experiences Using the Post...69 Appendix E : Focus Group Demographic Information Sheet . . . . . . . . . . . . . . 71 Appendix F: Interview Protocol for Non...Student Survey . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 S E R V I C E M E M B E R S I N S C H O O L i i i C

Boston Harbor, Massachusetts Feasibility Report for Debris Removal. Volume 2. Part A-Debris Inventory. Summary Sheets. Part B - Land Enhancement. Summary Sheets. Revision.

DTIC Science & Technology

1980-05-01

Holand -American line to Rotterdam, the Havana line to Havana, the American-Indian line from Calcutta, the China-Japan line from Yokohama and the Clay... f1 ) >i ’(D C 4- -𔃾 C - C) cc- 0i.L 0f 0’~ 44 U))v) 0 ~~5,~0 P) j ~ UCC 4-) .) - 0 ’ ~ 0 0~ 4-’ C)’C 0 00D fU LO. 00 C -H 𔃺*.4 Q ) U)j 0E . 00.3q C

U.S. EPA, Pesticide Product Label, MISTY GENERAL PURPOSE FLYING INSECT KILLER, 10/04/1995

EPA Pesticide Factsheets

2011-04-19

... f"!',lI,a! aI!rflllon INHALATION, f'c'·"',r wl,,,, to fIC~'l JI' r ... oj 3 N:I!'on~ PI'll~.'lnI n'sr"'~lfJ(' nm"'~tlon Sy ... 1 h'c! or' '!'(I '","' 1' ~~' .1",,~ e,,:., 1' !'lr I fen 1.1"" '.11 ...

M-X Environmental Technical Report. Socioeconomic Impact Estimates for Texas ROI Counties. Detailed Tables.

DTIC Science & Technology

1980-12-22

C LC0 a F L(i :> I c,. r- DC -0. _j- F 0> FL F . >m xz_ v Fj j . Z Z’- >0 D 14 4 iCC Li CO 04F _j- 4 .C(nm bC 4. u o 0j l 0 <--- m xcw -n Z 0 .j F -j... lC0 0 - (- rd WIj -I IOO 0- D 0 Id0 In miL r0 m Ii Qi W. Q N _j n z w < I S-i < N Iu m I I N jw > -N Ni Ih Ij j> L n -j> E r I ’ -I aIi ’ It 0 I ) x

Topics in Optical Materials and Device Research - II. Volume I.

DTIC Science & Technology

1982-01-01

Reflectometry Nicolet Optical Waveguide Computer Wavelength Multiplexing Silicon C it --l Pulse Generator CDSilicon Nitride 8 rystal-Growth Mechanism...expression for the power lost due to transition radiation will be given by SPTZ t) LA- L E- F, Q (18) -- 42 . c ; os )a -, - )(a+L - ~ O ~ o ~/-/3)CL - C /(d...IKe r1 ) J y 0 aJ., - C ,,-- O --) f2¢.,+-,) .T,,.,,() ,.(;,_, - LJ i (_1,,,, J _f-a.) - ao ,."T, (,) ,, ~Ca-)] (Al) / " 00,2 (fvid. = - L .z , ) (-1

Fluorine-Labeling as a Diagnostic for Thiol-Ligand and Gold Nanocluster Self-Assembly

DTIC Science & Technology

2009-01-01

A . Chandekar, S. K. Sengupta, C . M. F . Barry, J. L . Mead and J. E. Whitten...of O ( a factor up to 2.4) relative to its C:O:S:F composition remained although the relative compositions of C , S and F were consistent with the 6:2:1...and 2-prop- anol followed by a UV-ozone treatment (Samco International, Inc., Model UV-1 UV-Ozone stripper/cleaner) of 12 min at 150 C with a 0.50 L

[Homology analysis of the extended-V region of the surface proteins in different serotype Streptococcus mutans].

PubMed

He, Kui-Fang; Liu, Jian-Guo; Liu, Tian-Jia; Yang, De-Qin; Zhuang, Heng; Li, Song

2006-08-01

To analysis the homology among the extended-V region of the surface proteins in different serotype Streptococcus mutans (c, f, d, g) and to find out it's significance in anti-caries vaccine. The DNA of the bacteria (standarded serotype c, d, f, g and partial serotype c clinicals) was extracted and the extended-V region (SrV+, 1 384-2 514 bp) was amplified using polymerase chain reaction (PCR). Then the products were assessed using restriction fragment length polymorphism (RFLP) by endonuclease Dde I. The genotypings were sequenced and analysised using the program of BLAST on NCBI Gene Bank database. About 1.13 kb fragments were produced both in serotype c and f, the serotype d and g were failed. The RFLP results showed that five different patterns(A, B, C, D, E) among the 117 PCR products were reveled by Dde I. The ration of the genotypings A and B were the most among the strains, the C was lower, the D and E respectively was 1 and 3 strains per genotype. OMZ175 (serotype f) was belong to B genotype. Selected one of the A, B, C genotypings to sequenced and blasted. Then the results of the blastn showed that the identities of the gene sequence were 92%-98% between the serotype c and serotype f, part sequence of the serotype g was homology with the SrV+ of the serotype c, the protein sequence among serotype c, d, f, g were 77%-82%. It is reasonable to use some putative pipetides to study the anti-caries vaccine among the extended-V regions of the surface proteins in different serotype (c, d, f, g) in S. mutans.

Pulsewidth Modulated Speed Control of Brushless DC Motors.

DTIC Science & Technology

1984-09-01

sped acca - racy of the motoc is defined as tne difference Letweer the maximum and mir.imum motor speed divided by the commai. =e/ s~eed. TABLE I Motor...TO = .OOC C L N I5 THE SYvSTEM ELECTRICAL TIME CONSTANT lN = INCIC/RES F6 (1.c/FREcj D C/100. lIME =Ph 71ME2 l .CiFJREQ PMs C C EO IS THE BACK EtMF C...iu-8.2 J WR ITE (b , -0 I rI M 50 FGRM AT 11 ) t’I1N: 0,Fl 0 3,v ItM : a F10..3) WRITE (6t CC) IAV,IRMS 100 f -.FM tT 1 Xj IAV = ’ ,F 8.4,, v I11RMS F6

Non-Classical NF-kappaB Forms and Bcl-3 in Breast Cancer Development and Resistance to Cancer Therapy

DTIC Science & Technology

2006-06-01

Shores, E.W., Epstein, S., Grinberg, A., Tran, T., Shacter, E., Leonardi , A., Anver, M., et al. 1997. Critical roles for the Bcl-3 oncopro- tein in T...Leukemia 17: 1349–1356. Viatour, P., Dejardin, E., Warnier, M., Lair, F., Claudio , E., Bu- reau, F., Marine, J.C., Merville, M.P., Maurer, U., Green...Wessells, J., Baer, M., Young, H.A., Claudio , E., Brown, K., Siebenlist, U., and Johnson, P.F. 2004. BCL-3 and NF-B p50 attenuate

Mitigation of Confined Explosion Effects by Placing Water in Proximity of Explosives

DTIC Science & Technology

1992-08-01

fo rced conc re t e wa l l s and equlpment door; a s loped , f r a n g i b l e , cor ruga ted metal roof; and a smal l a t t ached s t r...r b lanket a re shown i n F igure 1. b. Replace t h e e x i s t i n g cor ruga ted metal roof wi th a p r e c a s t , R/concrete roo f

Purification and biochemical characterization of Mur ligases from Staphylococcus aureus.

PubMed

Patin, Delphine; Boniface, Audrey; Kovač, Andreja; Hervé, Mireille; Dementin, Sébastien; Barreteau, Hélène; Mengin-Lecreulx, Dominique; Blanot, Didier

2010-12-01

The Mur ligases (MurC, MurD, MurE and MurF) catalyze the stepwise synthesis of the UDP-N-acetylmuramoyl-pentapeptide precursor of peptidoglycan. The murC, murD, murE and murF genes from Staphylococcus aureus, a major pathogen, were cloned and the corresponding proteins were overproduced in Escherichia coli and purified as His(6)-tagged forms. Their biochemical properties were investigated and compared to those of the E. coli enzymes. Staphylococcal MurC accepted L-Ala, L-Ser and Gly as substrates, as the E. coli enzyme does, with a strong preference for L-Ala. S. aureus MurE was very specific for L-lysine and in particular did not accept meso-diaminopimelic acid as a substrate. This mirrors the E. coli MurE specificity, for which meso-diaminopimelic acid is the preferred substrate and L-lysine a very poor one. S. aureus MurF appeared less specific and accepted both forms (L-lysine and meso-diaminopimelic acid) of UDP-MurNAc-tripeptide, as the E. coli MurF does. The inverse and strict substrate specificities of the two MurE orthologues is thus responsible for the presence of exclusively meso-diaminopimelic acid and L-lysine at the third position of the peptide in the peptidoglycans of E. coli and S. aureus, respectively. The specific activities of the four Mur ligases were also determined in crude extracts of S. aureus and compared to cell requirements for peptidoglycan biosynthesis. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Using a modified Marcus model to analyze the Brønsted correlation of gas-phase reactions of the deprotonation of para-substituted toluenes by CH2Cl-, H(O)C-, CH3O-, H(F)N-, NH2C≡C-, and CH3C≡C- anions

NASA Astrophysics Data System (ADS)

Romanskii, I. A.

2017-10-01

Ab initio calculations of the energy parameters for a series of gas-phase reactions of the deprotonation of para-substituted toluenes (OH, CH3, H, Cl, NC, CN, and NO2 substituents) by CH2Cl-, H(O)C-, CH3O-, H(F)N-, NH2C≡C-, and CH3C≡C- anions (the conjugated acids are chloromethane (CH3Cl), formaldehyde (H2CO), methanol (CH3OH), fluoroamine (NH2F), aminoacetylene (NH2C≡CH), and methylacetylene (CH3C≡CH), respectively) is performed using a technique of intramolecular reorganization proposed earlier. The equilibrium ( E a eq) and nonequilibrium ( E a neq ) contributions to energy of activation E a are found for distance Q(C…B) = 3.0 Å (where C and B are the central atoms of the acid and base). At this value of Q, the tunneling mechanism of proton transfer predominates. The results from calculations, together with similar data obtained earlier for reactions of the deprotonation of toluenes by CH2CN- anions, are considered from the viewpoint of the harmonic Marcus model. It is found that in the graph Δ E 0 - E a neq (where Δ E 0 is the internal energy of the reaction (for a collision complex)), the points for five reaction series with C-bases fall on the same quadratic (within the -11 to 12 kcal/mol range of Δ E 0) curve; the second curve, which includes points for the series with N- and O-bases (OCH3 - and H(F)N-) is shifted below the first curve by 1.5 kcal/mol. For most reaction series (except the one with the strongest bases, CH2Cl- and H(O)C-), the curvature and slope of graph Δ E 0 - E a neq are in agreement with the theory. The correlations of energies E a neq , E a eq, E a, and Δ E 0 with the energy of reaction Δ E 00 are satisfactorily described by quadratic equations as well. Differences between the structures of bases are reflected most by energy E a eq and the height of the proton tunneling barrier in the activated complex (AC) E b. For the series of reactions of toluene with a set of bases, graphs Δ E 00 - E a eq and Δ E 0 - E b show good linear correlation between the values (opposite in sign) of departures from straight lines drawn through the points for two C-bases of the same type (CH2Cl- and CH2CN-).

Synthesis and structure of the first discrete dinuclear cationic aluminum complexes.

PubMed

Wang, Xingbao; Dorcet, Vincent; Luo, Yi; Carpentier, Jean-Francois; Kirillov, Evgueni

2016-08-02

The reactions of the charge neutral dinuclear aluminum tetraalkyl complexes of di-Schiff base ligands, i.e. [AlMe2{ON}-R-{ON}AlMe2] (1a, R = 1,3-propylene; 1b, R = 1,3-cyclohexylene) with B(C6F5)3 and [H(Et2O)2](+)[H2N{B(C6F5)3}2](-) were investigated. When B(C6F5)3 was used as the cationizing agent (1 or 2 equiv. vs. Al), only monocationic dinuclear complexes [2a,b]+[MeB(C6F5)3]- were obtained. In contrast, with [H(Et2O)2](+)[H2N{B(C6F5)3}2](-), both mixed-dicationic [3a,b·(OEt2)2]2+[MeB(C6F5)3]-[H2N{B(C6F5)3}2]- and homo-dicationic [3a,b·(OEt2)2]2+[H2N{B(C6F5)3}2]-2 ion-pairs were prepared. All cationic complexes were characterized by (1)H, (13)C, (19)F and (11)B NMR spectroscopy, and an X-ray diffraction study was performed for [3b·(OEt2)2]2+[H2N{B(C6F5)3}2]-2.

30 CFR 902.15 - Approval of Alaska regulatory program amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

...), .185(a)(3), (4), (5), .207(c)(5)(C), .213(g), (h), .323(a) through (d), .325(b), (c), (d)(1), (2), (3...), .349(2)(A), .353(a)(1), (2), (3), .371(d)(1) through (4), .373(b), (c), (d), .375(b), (e) through (h...), .491(a), (1), (6), (7), (8), (c)(4) through (8), (e), (f), .901(e), .907(c) through (h), (j). December...

30 CFR 902.15 - Approval of Alaska regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), .185(a)(3), (4), (5), .207(c)(5)(C), .213(g), (h), .323(a) through (d), .325(b), (c), (d)(1), (2), (3...), .349(2)(A), .353(a)(1), (2), (3), .371(d)(1) through (4), .373(b), (c), (d), .375(b), (e) through (h...), .491(a), (1), (6), (7), (8), (c)(4) through (8), (e), (f), .901(e), .907(c) through (h), (j). December...

Integrated Computer-Aided Manufacturing (ICAM) Architecture. Part 3. Volume 8. Technology Transfer.

DTIC Science & Technology

1983-09-01

AN’c MOp C O M P E T I T I V E D O S : 7 : .. .F ,- .,, Y T .. FINANCIAL RISK . "ON THE GO.ERM’" I2K_ IF, PROVIDES jNC-1.1,"L. TO-F, .NAKLS. ANC EIKN...RECENTLY, HO1WEVEP, :-XERNAL AND INTERNAL ENVIRONMENTAL PRESSURES HAVE FOCUSED; 7H GENERAL MANAGER’S AND HIS TOP FUNCTIONAL zTAF F’ S ATTENTION ON THE...SYSTieM DneFINITlO MEHOD Le He ~~~~h C~IDEF MEHDLGAIIAE etTERlog wNDElSTaDilG, tinTndaayisohhepolm COMMUNIATION, AN ANALYIS OF ESOLUTION. THE DENSIN IS

Analysis of Algorithms Predicting Blood: Air and Tissue: Blood Partition Coefficient from Solvent Partition Coefficients for Use in Complex Mixture Physiological Based Pharmacokinetic/Pharmacodynamic Modeling

DTIC Science & Technology

2004-03-01

8217)~)a EA~U M) 12. Cu 05 𔃺 ). C C a) a’r - (a 04 W- a’ En a 0 4) 0X0 a’ 1 En I W M*E .x 0 a 00o0 0 CLu 0 n4~) 0 S 5 cc 02. 0 3 02 0 0 0 0~ ~> CDL- F5 ...0 E E 0 0 0 E0 0 0 0 0 0 0 0 F5 Fn i Fn Fn Fn Fn Fn in Fn Fn Fn #AC U C U C U C C U C U () C) C C C C CC C C CC C C1 o) t_- c) c c o t)O L- C14- ) CD...a a W 4 0 0 Mu CD EL a..M C 0 -am- o uWMWWZZM W IL IL WWWWIM:Ma 0- Il (L(LWW WWI w t I 0) 0 a) a000) 0 C0 0r0 CcC_ C C C acCa .03 0 03 03 2 M 2

Lethality of home-style dehydrator processes against Escherichia coli O157:H7 and salmonella serovars in the manufacture of ground-and-formed beef jerky and the potential for using a pathogen surrogate in process validation.

PubMed

Borowski, A G; Ingham, S C; Ingham, B H

2009-10-01

Ground-and-formed beef jerky can be made easily at home with ground beef and kits that include spice, cure, and jerky-forming equipment. Ground beef poses inherent risks of illness due to Escherichia coli O157:H7 and Salmonella contamination, making adequate pathogen lethality important in jerky manufacturing. We evaluated the effectiveness of drying regimes at eliminating E. coli O157:H7 and Salmonella in seasoned ground-and-formed beef jerky manufactured with three home-style dehydrators and one small commercial unit. Inoculated jerky strips were dried for up to 12 or 24 h in a home-style or the commercial unit, respectively, with target drying temperatures ranging from 51.7 degrees C (125 degrees F) to 71.1 degrees C (160 degrees F). Pathogen lethality varied with seasoning, temperature, and drying time (n = 288 samples). Lethality against E. coli O157:H7 ranged from 1.5 log CFU (Jerky Xpress, 57.2 degrees C [135 degrees F], 4 h) to 6.4 log CFU (Gardenmaster, 68.3 degrees C [155 degrees F], 12 h), and varied with seasoning. Lethality against Salmonella ranged from 1.7 log CFU (Jerky Xpress, 57.2 degrees C [135 degrees F], 4 h) to 6.0 log CFU (Gardenmaster, 68.3 degrees C [155 degrees F], 12 h), and also varied with seasoning. There was a > or =5-log CFU reduction in both pathogens in 0, 10, and 27 % of samples at 4, 8, and 12 h, respectively. Heating jerky for 10 min at 135 degrees C (275 degrees F) 4 or 6 h postdrying increased lethality, on average, 2.99 log CFU for Salmonella and 3.02 log CFU for E. coli O157:H7. The use of a lactic acid bacterium culture (Pediococcus spp.) as a pathogen surrogate accurately predicted safety in 28 % of samples containing E. coli O157:H7 and 78% of Salmonella-inoculated samples.

Coder’s Manual: A Guide to TEPIAC Documentation.

DTIC Science & Technology

1977-07-01

Po Polonium Am Americium Hg Mercury Pr Praseodymium *Ar Argon (Hydrargyrum) Pt Platinum (also A) Ho Holmium Pu Plutonium *As Arsenic *1 Iodine Ra...Er 20 3 208 D ChD2 110 F F 2 Fe (FeF 21 209 E C 6H1 5ErO1 2S 3[Er(C 2 HSO 4)3] III G GaO4P [GaPO4] 210 F CH3 F 112 H 1iNO 212 G C8 H20Ge [Ge(C 2 H 5...Fluidity, 69 Heat conductance (contact), 62 Fluidized bed, 27 Heat conduction, 57 Fluorescence, 125 Heat conductivity, 57 Food products, 31 Heat content

Waterborne Commerce of the United States, Calendar Year 1982. Part 2. Waterways and Harbors, Gulf Coast, Mississippi River System and Antilles.

DTIC Science & Technology

1984-07-01

PRACTICABLE. THE COPY FURNISHED TO DTIC CONTAINED A SIGNIFICANT NUMBER OF PAGES WHICH DO NOT REPRODUCE LEGIBLY. ". * e ...CW July 1984 % 13. NUMBER OF PAGES• % ~~Forrestal Bldg, Stop 391 , RR E "’-虗 O Tn314 IS..nDECA IA T1ON/DDCNRAD4 1NG -% .M IOR.IN(; G ENpC3Y NAME...joK C) 1 -z $1N CL i5 - C0 -’ IN~ 0 0 Lj -f z 2 10 2 4b. La I \\ ~ E LsJ . ~’ %Q~f %V7 ~, z - %.at 0 - . V Q iJ A E / I 41 r-- 11 ;,4. 4 LLE 0c 01 q CLI

BciD Is a Radical S-Adenosyl-l-methionine (SAM) Enzyme That Completes Bacteriochlorophyllide e Biosynthesis by Oxidizing a Methyl Group into a Formyl Group at C-7.

PubMed

Thweatt, Jennifer L; Ferlez, Bryan H; Golbeck, John H; Bryant, Donald A

2017-01-27

Green bacteria are chlorophotorophs that synthesize bacteriochlorophyll (BChl) c, d, or e, which assemble into supramolecular, nanotubular structures in large light-harvesting structures called chlorosomes. The biosynthetic pathways of these chlorophylls are known except for one reaction. Null mutants of bciD, which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BChl e but accumulate BChl c; however, it is unknown whether BciD is sufficient to convert BChl c (or its precursor, bacteriochlorophyllide (BChlide) c) into BChl e (or BChlide e). To determine the function of BciD, we expressed the bciD gene of Chlorobaculum limnaeum strain DSMZ 1677 T in Escherichia coli and purified the enzyme under anoxic conditions. Electron paramagnetic resonance spectroscopy of BciD indicated that it contains a single [4Fe-4S] cluster. In assays containing SAM, BChlide c or d, and sodium dithionite, BciD catalyzed the conversion of SAM into 5'-deoxyadenosine and BChlide c or d into BChlide e or f, respectively. Our analyses also identified intermediates that are proposed to be 7 1 -OH-BChlide c and d Thus, BciD is a radical SAM enzyme that converts the methyl group of BChlide c or d into the formyl group of BChlide e or f This probably occurs by a mechanism involving consecutive hydroxylation reactions of the C-7 methyl group to form a geminal diol intermediate, which spontaneously dehydrates to produce the final products, BChlide e or BChlide f The demonstration that BciD is sufficient to catalyze the conversion of BChlide c into BChlide e completes the biosynthetic pathways for all "Chlorobium chlorophylls." © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

The Numerical Calculation of Traveling Wave Solutions of Nonlinear Parabolic Equations on the Line.

DTIC Science & Technology

1984-02-01

kc(i~~ +’~ which can be rewrittenw W (T is) Ic (sic) - (+ Using the convolution formulas and the expression for the inverse transform of-I (se e.g...2i 2f 1 2 c) + 4f1 1- f 3] 1 We now have: f ) (0,0,4) ; (2.17) f2 3(U) (0,0,0*) x 3 -, (0,,) . 3u ’ The inverse transform of (2.15) is given by: E

A single-molecule diode

NASA Astrophysics Data System (ADS)

Elbing, Mark; Ochs, Rolf; Koentopp, Max; Fischer, Matthias; von Hänisch, Carsten; Weigend, Florian; Evers, Ferdinand; Weber, Heiko B.; Mayor, Marcel

2005-06-01

We have designed and synthesized a molecular rod that consists of two weakly coupled electronic π -systems with mutually shifted energy levels. The asymmetry thus implied manifests itself in a current-voltage characteristic with pronounced dependence on the sign of the bias voltage, which makes the molecule a prototype for a molecular diode. The individual molecules were immobilized by sulfur-gold bonds between both electrodes of a mechanically controlled break junction, and their electronic transport properties have been investigated. The results indeed show diode-like current-voltage characteristics. In contrast to that, control experiments with symmetric molecular rods consisting of two identical π -systems did not show significant asymmetries in the transport properties. To investigate the underlying transport mechanism, phenomenological arguments are combined with calculations based on density functional theory. The theoretical analysis suggests that the bias dependence of the polarizability of the molecule feeds back into the current leading to an asymmetric shape of the current-voltage characteristics, similar to the phenomena in a semiconductor diode. Author contributions: F.E., H.B.W., and M.M. designed research; M.E., R.O., M.K., M.F., F.E., H.B.W., and M.M. performed research; M.E., R.O., M.K., M.F., C.v.H., F.W., F.E., H.B.W., and M.M. contributed new reagents/analytic tools; M.E., R.O., M.K., C.v.H., F.E., H.B.W., and M.M. analyzed data; and F.E., H.B.W., and M.M. wrote the paper.This paper was submitted directly (Track II) to the PNAS office.Abbreviations: A, acceptor; D, donor; MCB, mechanically controlled break junction.Data deposition: The atomic coordinates have been deposited in the Cambridge Structural Database, Cambridge Crystallographic Data Centre, Cambridge CB2 1EZ, United Kingdom (CSD reference no. 241632).

CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes

PubMed Central

Singh, Randeep K.; Dagnino, Lina

2017-01-01

The E2F1 transcription factor plays key roles in skin homeostasis. In the epidermis, E2F1 expression is essential for normal proliferation of undifferentiated keratinocytes, regeneration after injury and DNA repair following UV radiation-induced photodamage. Abnormal E2F1 expression promotes nonmelanoma skin carcinoma. In addition, E2F1 must be downregulated for proper keratinocyte differentiation, but the relevant mechanisms involved remain poorly understood. We show that differentiation signals induce a series of post-translational modifications in E2F1 that are jointly required for its downregulation. Analysis of the structural determinants that govern these processes revealed a central role for S403 and T433. In particular, substitution of these two amino acid residues with non-phosphorylatable alanine (E2F1 ST/A) interferes with E2F1 nuclear export, K11- and K48-linked polyubiquitylation and degradation in differentiated keratinocytes. In contrast, replacement of S403 and T433 with phosphomimetic aspartic acid to generate a pseudophosphorylated E2F1 mutant protein (E2F1 ST/D) generates a protein that is regulated in a manner indistinguishable from that of wild type E2F1. Cdh1 is an activating cofactor that interacts with the anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, promoting proteasomal degradation of various substrates. We found that Cdh1 associates with E2F1 in keratinocytes. Inhibition or RNAi-mediated silencing of Cdh1 prevents E2F1 degradation in response to differentiation signals. Our results reveal novel regulatory mechanisms that jointly modulate post-translational modifications and downregulation of E2F1, which are necessary for proper epidermal keratinocyte differentiation. PMID:27903963

CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.

PubMed

Singh, Randeep K; Dagnino, Lina

2017-01-17

The E2F1 transcription factor plays key roles in skin homeostasis. In the epidermis, E2F1 expression is essential for normal proliferation of undifferentiated keratinocytes, regeneration after injury and DNA repair following UV radiation-induced photodamage. Abnormal E2F1 expression promotes nonmelanoma skin carcinoma. In addition, E2F1 must be downregulated for proper keratinocyte differentiation, but the relevant mechanisms involved remain poorly understood. We show that differentiation signals induce a series of post-translational modifications in E2F1 that are jointly required for its downregulation. Analysis of the structural determinants that govern these processes revealed a central role for S403 and T433. In particular, substitution of these two amino acid residues with non-phosphorylatable alanine (E2F1 ST/A) interferes with E2F1 nuclear export, K11- and K48-linked polyubiquitylation and degradation in differentiated keratinocytes. In contrast, replacement of S403 and T433 with phosphomimetic aspartic acid to generate a pseudophosphorylated E2F1 mutant protein (E2F1 ST/D) generates a protein that is regulated in a manner indistinguishable from that of wild type E2F1. Cdh1 is an activating cofactor that interacts with the anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, promoting proteasomal degradation of various substrates. We found that Cdh1 associates with E2F1 in keratinocytes. Inhibition or RNAi-mediated silencing of Cdh1 prevents E2F1 degradation in response to differentiation signals. Our results reveal novel regulatory mechanisms that jointly modulate post-translational modifications and downregulation of E2F1, which are necessary for proper epidermal keratinocyte differentiation.

11 CFR 112.1 - Requests for advisory opinions (2 U.S.C. 437f(a)(1)).

Code of Federal Regulations, 2010 CFR

2010-01-01

... situation, or regarding the activities of third parties, do not qualify as advisory opinion requests. (c... Election Commission, Office of General Counsel, 999 E Street, NW., Washington, DC 20463. (f) Upon receipt...

Analysis and Interpretation of Current Measurements from the Beaufort Sea.

DTIC Science & Technology

1984-04-01

U D U) f Um cEkd& ~r3 d spot Ii.’ CfC ry4 0I 7D Co F- (I Lw r U)) 3UV ~~i(MC d U), F- U) H- 0 LL m U utaw02 sinLvdiE3.L (MM5A) an& N, p. - n - U.o CD~ u...U). rlb C.) w (f) td AD-R145 197 ANALYSIS AND INTERPRETATION OF CURRENT MEASUREMENTS 4/6 FROM THE BEAUFORT SEA(U) DOBROCKY SEATECH LTD SIDNEY7

Inclusion of Minority Patients in Breast Cancer Clinical Trials: The Role of the Clinical Trial Environment

DTIC Science & Technology

2010-05-01

physical environment and the social environment surrounding clinical trials. Task 6: Identify Breast Cancer Physicians in California, Florida...any of the following languages with your patients? a. Spanish b. Chinese ( Cantonese or Mandarin) c. Tagalog d. Vietnamese e. Korean f...Spanish b. Chinese ( Cantonese or Mandarin) c. Tagalog d. Vietnamese e. Korean f. Russian g. Other language(s) Yes No 1

On Predicting the Crystal Structure of Energetic Materials From Quantum Mechanics

DTIC Science & Technology

2008-12-01

DE ABSTRACT A quantum-mechanically-based potential energy function that describes interactions of dimers of the explosive ...method is capable of producing force fields for interactions of the molecular crystalline explosive RDX, and appears to be suitable to enable reliable...Ridge, TN. Byrd, E.F.C., Scuseria, G.E., Chabalowski, C.F., 2004: “An ab initio study of solid nitromethane , HMX, RDX and CL20: Successes and

78 FR 24985 - Amendment of Restricted Areas R-6703A, B, C, D; and Establishment of Restricted Areas R-6703E, F...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...-0371; Airspace Docket No. 12-ANM-14] RIN 2120-AA66 Amendment of Restricted Areas R-6703A, B, C, D; and Establishment of Restricted Areas R-6703E, F, G, H, I, and J; WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies the internal boundaries of R-6703 by further...

76 FR 20237 - Approval and Promulgation of Air Quality Implementation Plans; District of Columbia; Section 110...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... 1997 PM 2.5 NAAQS dated October 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K...), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M) necessary to implement, maintain, and... September 22, 2008 addressed the section 110(a)(2) requirements for the 1997 PM 2.5 NAAQS; and the submittal...

DNA fingerprinting of isolates of Streptococcus mutans by pulsed-field gel electrophoresis.

PubMed

Mineyama, R; Yoshino, S; Maeda, N

2007-01-01

Forty isolates and five standard laboratory strains, representing serotypes c, e and f of Streptococcus mutans were analyzed by pulsed-field gel electrophoresis (PFGE) after digestion of the genomic DNA with BssH II. The digestion patterns of standard laboratory strains were characteristic of serotypes c, e and f. Serotypes c and f generated diagnostic DNA fragments of approximately 145 kbp and of approximately 130-175 kbp in length, respectively. Serotype e generated a ladder of at least 14 fragments of 15-155 kbp in length. The digestion patterns of isolates were essentially similar to those of the standard laboratory strains. The patterns of almost all isolates obtained from a single individual were identical, but patterns of a few different types were also observed among isolates obtained from two individuals. Digestion with BssH II revealed differences among isolates obtained from different individuals. We used differences in banding patterns among isolates to construct a dendrogram. The dendrogram included two major clusters, one that consisted of isolates of serotypes c and f, and an other that consisted of isolates of serotype e. Our results indicate that BssH II is a useful enzyme for distinguishing among isolates of S. mutans and that digestion patterns obtained by PFGE can be used for chromosomal DNA fingerprinting.

Determination of the Rapid Quenching Rates of Excited State F-Centers by OH(-) Defects in KC1.

DTIC Science & Technology

1986-08-29

M. A. E - eDr. George E. Walrafen Departme f Chemistry Department of Chemistry Univ ty of California Howard University . Angeles, California 90024...Wilson Department of Chemistry Chemistry Department Howard University University of California Washington, D.C. 20059 La Jolla, California 92093 Dr. M. S

Development of a Piezoelectric Polymer Film Pressure Transducer for Low Frequency and Dynamic Pressure Measurement

DTIC Science & Technology

1990-12-01

Sample LOTUS 123 Cell Formulas for Reducing Reset Data A2: 0.0008 B2: 0.564 C2: -2.501 02: (A1-$A$1) E2: (@IF(@ABS(C2)>2,@TRUE,@FALSE)=1) F2: (@IF(E2...9 F14: (@IF( El4 =1,0,0.951*C14)) H14: (G14- 12 .492*D14) A15: 0.0034 B15: -0.248 015: 0.033 D15: (A14-$A$l) G15: @IF(El5=O, (F15+$G$1 1), (($G$1 1+Gl4...data corrected for rise rate and zero mean. I I F-4 I LOTUS 123 Cell Formulas Used to Reconstruct the Sine Data Al: 0.00324 Bi: -0.01 Cl: -0.14 D1: (Al

Toxicity Determinations for Five Energetic Materials, Weathered and Aged in Soil, to the Collembolan Folsomia Candida

DTIC Science & Technology

2015-03-01

polypropylene ...ai n in g A C N - E x tr ac ta b le (F in al /I n it ia l) In it ia l A n al y si s2 (m g /k g ) F in al A n al y si s3 (m g /k g...R em ai n in g A C N - E x tr ac ta b le (F in al /I n it ia l) In it ia l A n al y si s2 (m g /k g ) F in al A n al y si s3 (m g /k

Analysis and Forecasting of Operating and Support Costs for F-16 C/D

DTIC Science & Technology

2006-06-01

Wydra,” F-16 Oferta Offsetowa,” [in Polish] Wiraże, no. 3 (2003...the country spending money on purchases in the public sector. This is one method for promoting economic growth.25 All offset agreements between the...Zdzislaw Wydra, ”F-16 Oferta Offsetowa,” [in Polish] Wiraże, no. 3 (2003), http://www.czasopismawlop.mil.pl/wiraze/w_numerzew/archiwumw/3-2003/f16o.htm

Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols.

PubMed

Nihei, Takashi; Yokotani, Saya; Ishihara, Takashi; Konno, Tsutomu

2014-02-14

Highly nucleophilic (Z)- or (E)-α-fluoroalkenylchromium species could be generated in a stereoselective manner via C-F bond activation of CBrF2-containing molecules, and they reacted smoothly with various aldehydes to give (E)- or (Z)-β-fluoroallylic alcohol derivatives in high yields, respectively.

Coumarin based colorimetric and fluorescence on-off chemosensor for F-, CN- and Cu2 + ions

NASA Astrophysics Data System (ADS)

Roy, Debashis; Chakraborty, Arijit; Ghosh, Rina

2018-02-01

(E)-4-Chloro-3-[{2-(4-nitrophenyl)hydrazono}methyl]-2H-chromen-2-one (C), a coumarin derivative has been studied toward its ion sensing properties for F-, CN- and Cu2 +. A proton-transfer mechanism for F- sensing has been deduced with the help of 1H NMR titration alongwith from the changes in the absorption and emission spectra of C in the presence of F-. C formed 1:1 stoichiometric complex with each of these analytes. Sensing of C toward Cu2 + is poor, but interestingly in the presence of F- or CN- the sensing ability of Cu2 + gets enhanced many folds, and C can act as F- or CN- mediated off-on sensor for Cu2 +. Moreover, colorimetric strip (pre-coated with the coumarin derived compound) tests for F- and CN- from their DMSO solution at high temperature ( 100 °C) opens up the door for easiest naked eye recognition and distinction of these ions, and also for naked-eye detection of F- and CN- from its aqueous solution at high temperature ( 100 °C).

Bisphosphonate-ciprofloxacin bound to Skelite is a prototype for enhancing experimental local antibiotic delivery to injured bone.

PubMed

Buxton, T B; Walsh, D S; Harvey, S B; McPherson, J C; Hartmann, J F; Plowman, K M

2004-09-01

The risk of osteomyelitis after open bone fracture may be reduced by locally applied antibiotics. ENC-41-HP (E41), which comprises ciprofloxacin linked to a 'bone seeking' bisphosphonate, loaded on to carrier Skelite calcium phosphate granules (E41-Skelite) has favourable in vitro characteristics for application to wounded bone. This study assessed E41-Skelite in a rat model of acute tibial osteomyelitis. Mechanically induced tibial troughs were contaminated with approximately log10 4 colony forming units (c.f.u.) of Staphylococcus aureus (Cowan 1 strain) 'resistant' to E41 (minimum inhibitory concentration 8-16 microg/ml), lavaged and packed with Skelite alone, or with E41-Skelite slurry. Animals were killed at 24 h (n = 62), 72 h (n = 46) or 14 days (n = 12), and each tibia was assessed for S. aureus load (c.f.u./g tibia) and histological appearance (14 days only). At 24 and 72 h, the tibias of rats treated with E41-Skelite (n = 54) had a significantly lower mean (s.e.m.) load of S. aureus than animals that received Skelite alone (n = 54): log10 3.6(0.2) versus 6.4(0.1) c.f.u./g respectively at 24 h (P < 0.001, Mann-Whitney rank sum test) and log10 4.4(0.2) versus 6.6(0.1) c.f.u./g at 72 h (P < 0.001). At 14 days, E41-Skelite-treated tibias had fewer bacteria, no signs of osteomyelitis and histological signs of healing. E41-Skelite, a prototype granulated topical antibiotic delivery system, reduced the development of infection in experimental bone wounds. Copyright 2004 British Journal of Surgery Society Ltd.

STM study of C60F18 high dipole moment molecules on Au(111)

NASA Astrophysics Data System (ADS)

Bairagi, K.; Bellec, A.; Chumakov, R. G.; Menshikov, K. A.; Lagoute, J.; Chacon, C.; Girard, Y.; Rousset, S.; Repain, V.; Lebedev, A. M.; Sukhanov, L. P.; Svechnikov, N. Yu.; Stankevich, V. G.

2015-11-01

Scanning tunneling microscopy and spectroscopy studies of C60F18 molecules deposited on Au(111) are reported and compared to C60 molecules both at liquid helium temperature and room temperature (RT). Whereas adsorption and electronic properties of C60F18 single molecules were studied at low temperature (LT), self-assemblies were investigated at RT. In both cases, the fluorine atoms of the C60F18 molecules are pointed towards the surface. Individual C60F18 molecules on Au(111) have a HOMO-LUMO gap of 2.9 eV. The self-assembled islands exhibit a close-packed hexagonal lattice with amorphous borders. The comparison with C60 molecules clearly demonstrates the influence of the C60F18 electric dipole moment (EDM) on the electronic properties of single molecules and on the thermodynamics of self-assembled islands. Besides, the apparent height value of a separate molecule increases in a self-assembly environment as a result of a depolarization phenomenon.

Apprentice Class Graduates

NASA Image and Video Library

1960-05-14

Apprentice Class Graduates: 32 Apprentice Greaduates: Ivan E. Albertson, Colossie N. Batts, Billy W. Beasley, John H. Belveal, Ernest R. Dunnigan, Durwood W. Davis, Charles E. Drummond, John R.Ellingsworth, Jr., Hugh D. Fitzgerald, Ernest A. Gurganus, Joseph R. Guy, William C. Henley,Jr., Richard N. Hill, Hiram R. Hogge, Jr., James D. Holt, James L. Hudgins, Robert F. Macklin, Roy W. Mason, Clyde J. May,Roger N. Messier, William C. Moughon, William S. Pillow, Wayne R. Posey, Mark E. Price, John W. Schwartz, Herbert F. Shackleford, John W. Simpson,John B. Slight, Cecil W. Stephens, Richard K. Stoops, John W. Sundy, Dave, E. Williams.

Modeling and Simulation of Ceramic Arrays to Improve Ballaistic Performance

DTIC Science & Technology

2013-09-01

2219 , 2000. -Boundary conditions were modified in order to achieve better...a . 3 0) E o 0 da tio n im en ts ■ co nd iti tt er d a al ys is i at e ri al If- sy m m pt h o f P ge ts w it c CD in g S P...H M od el v al i< D oP e xp er 22 19 ,2 00 0 CO 0 ■o > C 0 3 "E rt h er a n ec t o f m (0 CD £ IQ J2. 0) ■Q E CO 3 o

Type 1 Hot Corrosion Furnace Testing and Evaluation.

DTIC Science & Technology

1982-10-01

Mixed Temperature Mode Burner Rig Test, Aprigliano, L. F., pp. 6-7, September 1980. 18. Giggins, C. S. and Pettit, F. S ., op . cit. 19. David W. Taylor...X. and Duhl, D. N., op. cit. 24. Green, K. A. and Nichols, E. S ., op . cit. 25. Aprigliano, L. F., op. cit. 26. Green, K. A. and Nichols, E. S ., op . cit

Electron Collision Shift of the Lyman-Alpha Line in H and He+

DTIC Science & Technology

1988-09-09

K ’ O iA ONA ’F’ )E i CE ’ O...ViDshing ton, DC 20375-5000 ’,.- K ..r, ’ 5 SO/I Ni, Sr. O (c), S VBO 9 ""Cl( ’/ N S’$ , N’ Dr. (A -i N VhF ()R(,A l ,’A 0ON (if apph(able) Office of...defined by c ~n C k CL SI~p ppkpppp, a n e k C L S p p pkp p p p S kp ( k ) momentum of the colliding electron before (after) the collision, L S =

Morphologic characterization of the patent ductus arteriosus in the premature infant and the choice of transcatheter occlusion device.

PubMed

Philip, Ranjit; Waller, B Rush; Agrawal, Vijaykumar; Wright, Dena; Arevalo, Alejandro; Zurakowski, David; Sathanandam, Shyam

2016-02-01

The aim of this study was to describe and differentiate the morphology of patent ductus arteriosus (PDA) seen in children born prematurely from other PDA types. PDAs are currently classified as types A-E using the Krichenko's classification. Children born prematurely with a PDA morphology that did not fit this classification were described as Type F PDA. A review of 100 consecutive children who underwent transcatheter device closure of PDA was performed. The diameter and length (L) of the PDA and the device diameter (D) were indexed to the descending aorta (DA) diameter. Comparison of 26 Type F PDAs was performed against, 29 Type A, 7 Type C and 32 Type E PDAs. Children with Type F PDAs (median 27.5 weeks gestation) were younger during the device occlusion compared with types A, C, and E (median age: 6 vs. 32, 11, and 42 months; P = 0.002). Type F PDAs were longer and larger, requiring a relatively large device for occlusion than types A, C, and E (Mean L/DA: 1.88 vs. 0.9, 1.21, and 0.89, P ≤ 0.01 and Mean D/DA: 1.04 vs. 0.46, 0.87, and 0.34, P ≤0.01). The Amplatzer vascular plug-II (AVP-II) was preferred for occlusion of Type F PDAs (85%; P <0.001). Children born prematurely have relatively larger and longer PDAs. These "fetal type PDAs" are best classified separately. We propose to classify them as Type F PDAs to add to types A-E currently in use. The AVP-II was effective in occluding Type F PDAs. © 2015 Wiley Periodicals, Inc.

Experimental and DFT Studies of the Electron-Withdrawing Ability of Perfluoroalkyl (R F) Groups: Electron Affinities of PAH(R F) n Increase Significantly with Increasing R F Chain Length

DOE Office of Scientific and Technical Information (OSTI.GOV)

San, Long K.; Spisak, Sarah N.; Dubceac, Cristina

Two series of aromatic compounds with perfluoroalkyl (RF) groups of increasing length, 1,3,5,7-naphthalene(RF)4 and 1,3,5,7,9-corannulene(RF)5, have been prepared and their electronic properties studied by low-temperature PES (i.e., gas-phase electron affinity (EA) measurements). These and many related compounds were also studied by DFT calculations. The data demonstrate unambiguously that the electron-withdrawing ability of RF substituents increases significantly and uniformly from CF3 to C2F5 to n-C3F7 to n-C4F9.

Experimental and DFT Studies of the Electron-Withdrawing Ability of Perfluoroalkyl (R-F) Groups: Electron Affinities of PAH(R-F)(n) Increase Significantly with Increasing R-F Chain Length

DOE Office of Scientific and Technical Information (OSTI.GOV)

San, Long K.; Spisak, Sarah N.; Dubceac, Cristina

2018-01-26

Two series of aromatic compounds with perfluoroalkyl (RF) groups of increasing length, 1,3,5,7-naphthalene(RF)4 and 1,3,5,7,9-corannulene(RF)5, have been prepared and their electronic properties studied by low-temperature PES (i.e., gas-phase electron affinity (EA) measurements). These and many related compounds were also studied by DFT calculations. The data demonstrate unambiguously that the electron-withdrawing ability of RF substituents increases significantly and uniformly from CF3 to C2F5 to n-C3F7 to n-C4F9.

78 FR 33357 - Takes of Marine Mammals Incidental to Specified Activities; Taking Marine Mammals Incidental to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-04

...) Program. Multiple munitions (bombs, missiles, and gunner rounds) and aircraft would be used to meet the... with Munitions specific munitions) GBU-10 laser-guided Mk-84 bomb F-16C fighter aircraft. GBU-24 laser-guided Mk-84 bomb F-16C+ fighter aircraft. GBU-31 Joint Direct Attack Munition, F-15E fighter aircraft...

Air Force Office of Scientific Research (AFOSR) Technical Report Summaries. Third Quarter (CY).

DTIC Science & Technology

1984-10-01

Iy ?A ’ C .- * tD ’ 0 ~ E 0 41 3nv *i ; I-t u s4*Cw I *0 *L4 . 0 0u -C 0.0 -Az Z%- LL C .I ;; L’v > . --.0 g L’ a LC - L . L! >LI in 06 i E c) I i I...a) In~~~ 111C 0 .I Cto 01 04 4 C U)0 C4 0 0f 0 - I- m 0~ tD X*~ 4** L* C4 0.*aOC n L, .4 1’X ’ 01- 0 0)4 40’ EC M L. (. L1t- CO f 0o Si 04 l 11111...lx 0- 03 0E i( Vu ox ’- 0 I 0IJ. L. .59 M SE 0 i 0 SEh*~~~U hi4 . . td I IA. 2 4, 0 C3 StL 0 an C 64(4 0 0- m *0 0 ScSt h Im 0 m- 0 0-L- SE E, 0x V.C a

Modular Air Defense Effectiveness Model, Program Documentation and User’s Guide. Volume II. MADEM Programmer Manual.

DTIC Science & Technology

1980-01-31

Nuclear Agency 13 NUMFIER OF PAGES Washington, D.C. 20305 534 14 MONITORING AGENCY NAME 8 ADDRESS(,! itI(reI t &,n, ( f n ... o.I.n. Offi,e) 15...Initialization 13 3. Storage Management 13 4. Event Control 14 E. Diagnostics 17 1. Debug Routines 17 2. Data Structure Display Routines 19 F . Software...Structures 71 1. Player Lists 72 2. C2 Trees 78 3. Passive Target List 86 F . RED Structures 89 1. Red Theater Commander 90 2. Potential Target List 98 3

Powered Conveyor System for Tray Pack. Short Term Project No. 1

DTIC Science & Technology

1991-08-28

responsibilities are de- scribed in the Technical and Cost Proposals for STP # 1 . 3.0 Short Term Project Activities 3.1 Technology Review & Preliminary...I - ------- F f~/ AD-A241 562: CMBAT RATION TECHNOLOGY DEMONSTRATION (CRAMTD) PtIwered onveyor Systein fbrfray Ph&k Short Tenn Piject # 1 -, TNAL...REPORT’ A ~~~STP Results and Acmolislssents (Odober 1989to~~ 1 91 Rpe ar.o.CRAMTDSlP #.L rR.-LO q~eO~4DTI.’ cRAi.4m CwcE~rA NO. DLA90088D-033 g ELECTb f C

Molecular Genetic and Gene Therapy Studies of the Musculoskeletal System

DTIC Science & Technology

2004-10-01

H3023F07 Cct5 GO:0006457 protein folding H3023D07 D630041 K24Rik GO:0006464 protein modification H3066E06 C430014H23Rik GO:0006468 protein amino acid ...phosphorylation H3057F01 Csnkle GO:0006468 protein amino acid phosphorylation H3063A08 Lgmn GO:0006508 proteolysis and peptidolysis H3048C09 Fbxl12 GO...H3001E07 0.45 UNKNOWN H3057F01 Csnkle 0.44 Mus musculus casein circadian kinase 1, epsilon rhythm(GO:0007623);protein (Csnkle), mRNA amino acid

One-pot formation of 1,3,4-oxadiazol-2(3H)-ones and dibenzo[c,e]azepines by concomitant cathodic reduction of diazonium salts and phenanthrenequinones.

PubMed

Batanero, Belen; Barba, Fructuoso; Martin, Avelino

2013-09-20

The one-pot concomitant electrochemical reduction of phenanthrenequinones (1, 2) and arenediazonium salts (3a-f) led to the formation of 1,3,4-oxadiazol-2(3H)-ones (4a-f, 5a) and dibenzo[c,e]azepines (6a-f) when N-methylformamide was used as the solvent. A new pathway, different from those previously described with other aprotic solvents, is proposed. The experimental data support a radical mechanism for the electrochemical process followed by an internal rearrangement to give the products.

A synthetic mechano-growth factor E peptide promotes rat tenocyte migration by lessening cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signaling pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Bingyu; Luo, Qing, E-mail: qing.luo@cqu.edu.cn; Mao, Xinjian

Tendon injuries are common in sports and are frequent reasons for orthopedic consultations. The management of damaged tendons is one of the most challenging problems in orthopedics. Mechano-growth factor (MGF), a recently discovered growth repair factor, plays positive roles in tissue repair through the improvement of cell proliferation and migration and the protection of cells against injury-induced apoptosis. However, it remains unclear whether MGF has the potential to accelerate tendon repair. We used a scratch wound assay in this study to demonstrate that MGF-C25E (a synthetic mechano-growth factor E peptide) promotes the migration of rat tenocytes and that this promotionmore » is accompanied by an elevation in the expression of the following signaling molecules: focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1/2). Inhibitors of the FAK and ERK1/2 pathways inhibited the MGF-C25E-induced tenocyte migration, indicating that MGF-C25E promotes tenocyte migration through the FAK-ERK1/2 signaling pathway. The analysis of the mechanical properties showed that the Young's modulus of tenocytes was decreased through treatment of MGF-C25E, and an obvious formation of pseudopodia and F-actin was observed in MGF-C25E-treated tenocytes. The inhibition of the FAK or ERK1/2 signals restored the decrease in Young's modulus and inhibited the formation of pseudopodia and F-actin. Overall, our study demonstrated that MGF-C25E promotes rat tenocyte migration by lessening cell stiffness and increasing pseudopodia formation via the FAK-ERK1/2 signaling pathway. - Highlights: • Mechano-growth factor E peptide (MGF-C25E) promotes migration of rat tenocytes. • MGF-C25E activates the FAK-ERK1/2 pathway in rat tenocytes. • MGF-C25E induces the actin remodeling and the formation of pseudopodia, and decreases the stiffness in rat tenocytes. • MGF-C25E promotes tenocyte migration via altering stiffness and forming pseudopodia by the activation of the FAK-ERK1/2 pathway.« less

Fire Incident Reporting Manual

DTIC Science & Technology

1984-02-01

Purpose 1-1 B. Scope 1-1 C. Procedures 1-1 D. Exclusions 1-3 E . Preparation 1-3 F. Information Requirements 1-4 CHAPTER 2 - INSTRUCTIONS FOR PREPARING DoD...Structure and Fire Data 2-16 4. Section D - Fire Protection Facilities (In Structures Only) 2-28 5. Section E - Losses 2-30 6. Section F - Times (24...Activities Program," February 21, 1976 ( e ) National Fire Protection Association (NFPA) Standard 901, "Uniform Coding for Fire Protection," 1976 (f) NFPA

Direct Energy Conversion Literature Abstracts

DTIC Science & Technology

1963-12-01

as the temperature rises through -35 C. nonalkali glass containing Fe oxide. The For all high-purity specimens this thermal e.m.f. and the contact...potentiometer at >3000. is affected very little by variations in The thermal e.m.f. of nonalkali glass the interstitial impurities nitrogen and...by changes The thermal e.m.f. depends on the com- in grain size. The results are considered position of the glass and varies from 0.55 in terms of

CCAAT/enhancer-binding protein beta inhibits proliferation in monocytic cells by affecting the retinoblastoma protein/E2F/cyclin E pathway but is not directly required for macrophage morphology.

PubMed

Gutsch, Romina; Kandemir, Judith D; Pietsch, Daniel; Cappello, Christian; Meyer, Johann; Simanowski, Kathrin; Huber, René; Brand, Korbinian

2011-07-01

Monocytic differentiation is orchestrated by complex networks that are not fully understood. This study further elucidates the involvement of transcription factor CCAAT/enhancer-binding protein β (C/EBPβ). Initially, we demonstrated a marked increase in nuclear C/EBPβ-liver-enriched activating protein* (LAP*)/liver-enriched activating protein (LAP) levels and LAP/liver-enriched inhibiting protein (LIP) ratios in phorbol 12-myristate 13-acetate (PMA)-treated differentiating THP-1 premonocytic cells accompanied by reduced proliferation. To directly study C/EBPβ effects on monocytic cells, we generated novel THP-1-derived (low endogenous C/EBPβ) cell lines stably overexpressing C/EBPβ isoforms. Most importantly, cells predominantly overexpressing LAP* (C/EBPβ-long), but not those overexpressing LIP (C/EBPβ-short), exhibited a reduced proliferation, with no effect on morphology. PMA-induced inhibition of proliferation was attenuated in C/EBPβ-short cells. In C/EBPβ(WT) macrophage-like cells (high endogenous C/EBPβ), we measured a reduced proliferation/cycling index compared with C/EBPβ(KO). The typical macrophage morphology was only observed in C/EBPβ(WT), whereas C/EBPβ(KO) stayed round. C/EBPα did not compensate for C/EBPβ effects on proliferation/morphology. Serum reduction, an independent approach known to inhibit proliferation, induced macrophage morphology in C/EBPβ(KO) macrophage-like cells but not THP-1. In PMA-treated THP-1 and C/EBPβ-long cells, a reduced phosphorylation of cell cycle repressor retinoblastoma was found. In addition, C/EBPβ-long cells showed reduced c-Myc expression accompanied by increased CDK inhibitor p27 and reduced cyclin D1 levels. Finally, C/EBPβ-long and C/EBPβ(WT) cells exhibited low E2F1 and cyclin E levels, and C/EBPβ overexpression was found to inhibit cyclin E1 promoter-dependent transcription. Our results suggest that C/EBPβ reduces monocytic proliferation by affecting the retinoblastoma/E2F/cyclin E pathway and that it may contribute to, but is not directly required for, macrophage morphology. Inhibition of proliferation by C/EBPβ may be important for coordinated monocytic differentiation.

Introduction to Some Fundamental Concepts of General Relativity and to Their Required Use in Some Modern Timekeeping Systems

DTIC Science & Technology

1981-12-01

t e d Riemann Curvature Wnsor and R i s the Curva ture ~ c 2 l ) a r . I n 1917, Karl Schwarzschi ld s o l v e d t h e s e e q u a t i o n...tu re of time a l o n e . I t is t h e Schwarzschild met r ic t h a t leads t o the famous concept n f t h e black h o l e . This is a...01 Well, it can: 2 m - I - - - - - 0 r c 2 Figure 2 4 One calls t h i s va lue of r t h e Schwarzschild b d l u s and o f t e n

Expression of galectin-3, cytokeratin 19, neural cell adhesion molecule and E-cadhedrin in certain variants of papillary thyroid carcinoma.

PubMed

Laco, J; Ryska, A; Cáp, J; Celakovský, P

2008-10-01

The immunohistochemical expression of galectin-3 (Gal3), cytokeratin 19 (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) was evaluated to assess their use in diagnostics of papillary thyroid carcinoma (PTC). A total of 84 PTCs - 36 classical variants (cPTCs), 26 follicular variants (fPTCs), and 22 papillary microcarcinomas (mPTCs) were studied. Expression of Gal3 was found in 36/36 (100%) cPTCs, 24/26 (92%) fPTCs, and 19/22 (86%) mPTCs. CK19 expression was detected in 34/36 (94%) cPTCs, 17/26 (65%) fPTCs, and 13/22 (59%) mPTCs. Expression of NCAM was seen in 5/36 (14%) cPTCs, 7/26 (27%) fPTCs, and 9/22 (41%) mPTCs. Ecad expression was found in 23/36 (64%) cPTCs, 17/26 (65%) fPTCs, and 18/22 (82%) mPTCs. A significant difference in CK19 expression was observed between cPTC and both fPTC and mPTC (p < 0.001). Furthermore, extrathyroid tumor spread significantly correlated with both level of CK19 expression and loss of Ecad expression (p = 0.001, p = 0.04). Our findings suggest that Gal3 and CK19 are useful markers for PTC, although decreased CK19 expression in mPTC and fPTC must be considered. Furthermore, CK19 and Ecad may play a role in extrathyroid tumor spread.

Compositions, thermodynamic properties, and transport coefficients of high-temperature C5F10O mixed with CO2 and O2 as substitutes for SF6 to reduce global warming potential

NASA Astrophysics Data System (ADS)

Zhong, Linlin; Rong, Mingzhe; Wang, Xiaohua; Wu, Junhui; Han, Guiquan; Han, Guohui; Lu, Yanhui; Yang, Aijun; Wu, Yi

2017-07-01

C5F10O has recently been found to be a very promising alternative to SF6. This paper is devoted to the investigation of compositions, thermodynamic properties, and transport coefficients of high-temperature C5F10O mixed with CO2 and O2. Firstly, the partition functions and enthalpies of formation for a few molecules (CxFy and CxFyO) which are likely to exist in the mixtures, are calculated based on the G4(MP2) theory. The isomers of the above molecules are selected according to their Gibbs energy. The compositions of C5F10O-CO2-O2 mixtures are then determined using the minimization of the Gibbs free energy. Next, the thermodynamic properties (mass density, specific enthalpy, and specific heat) are derived from the previously calculated compositions. Lastly, the transport coefficients (electrical conductivity, viscosity, and thermal conductivity) are calculated based on Chapman-Enskog method. It is found that, as an arc quenching gas, C5F10O could not recombine into itself with the temperature decreasing down to room temperature after the arc extinction. Besides, the key species at room temperature are always CF4, CO2, and C4F6 if graphite is not considered. When taken into account, graphite will replace C4F6 as one of the dominate particles. The mixing of CO2 with C5F10O plasma significantly affects the thermodynamic properties (e.g. vanishing and/or shifting of the peaks in specific heat) and transport coefficients (e.g. reducing viscosity and changing the number of peaks in thermal conductivity), while the addition of O2 with C5F10O-CO2 mixtures has no remarkable influence on both thermodynamic and transport properties.

75 FR 52060 - Qualification of Drivers; Exemption Renewals; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

...., Delmas C. Bergdoll, Kenneth J. Bernard, Allen G. Bors, Brad T. Braegger, Michael C. Branham, John E. Breslin, Trixie L. Brown, Raymond L. Brush, Scott F. Chalfant, Leroy A. Chambers, Harvis P. Cosby, Rodney... L. Tysseling, Kenneth E. Walker and Richard G. Wendt. In accordance with 49 U.S.C. 31136(e) and...

Total reaction cross sections of electronic state-specified transition metal cations: V + +C2H6, C3H8, and C2H4 at 0.2 eV

NASA Astrophysics Data System (ADS)

Sanders, Lary; Hanton, Scott D.; Weisshaar, James C.

1990-03-01

We describe a crossed beam experiment which measures total cross sections for reaction of electronic state-specified V+ with small hydrocarbons at well-defined collision energy E=0.2 eV. The V+ state distribution created at each ionizing wavelength is directly measured by angle-integrated photoelectron spectroscopy (preceding paper). Reactant and product ions are collected and analyzed by pulsed time-of-flight mass spectrometry following a reaction time of 6 μs. Tests of the performance of the apparatus are described in detail. Our experiment defines the reactant V+ electronic state distribution and the collision energy much more precisely than previous work. For all three hydrocarbons C2H6, C3H8, and C2H4, H2 elimination products dominate at 0.2 eV. We observe a dramatic dependence of cross section on the V+ electronic term. The second excited term 3d34s(3F) is more reactive than either lower energy quintet term 3d4(5D) or 3d34s(5F) by a factor of ≥270, 80, and ≥6 for the C2H6, C3H8, and C2H4 reactions, respectively. The 3d34s(3F) reaction cross sections at 0.2 eV are 20±11 Å2, 37±19 Å2, and 2.7±1.6 Å2, respectively, compared with Langevin cross sections of ˜80 Å2. For the C2H6 and C3H8 reactions, cross sections are independent of initial spin-orbit level J within the 3F term to the limits of our accuracy. Comparison with earlier work by Armentrout and co-workers shows that electronic excitation to d3s(3F) is far more effective at promoting H2 elimination than addition of the same total kinetic energy to reactants. Electron spin is clearly a key determinant of V+ reactivity with small hydrocarbons. We suggest that triplet V+ reacts much more efficiently than quintet V+ because of its ability to conserve total electron spin along paths to insertion in a C-H bond of the hydrocarbon.

National Program for Inspection of Non-Federal Dams. Addison Pond Dam (CT 00245), Connecticut River Basin, Glastonbury, Connecticut. Phase I Inspection Report.

DTIC Science & Technology

1981-04-01

43 696 NTIONAL FRUW FO1 INSPECTION OF NQN-FERINL HAlS in1 ADDISON PON DAN (CT.. (U) CORPS OF ENGINEERS WLTINN ANLAD I IUCLASSIFIED F/0 1311±3...S ThS A, - 7~c~ C. FA A -:Loo T A-r’o N= ,o AT/ Pip, : Eo 0-’Z’ A --’ * 5’so’ -A90/4 E~ \\ s ~c Ac F P4 A- , -S- ST~fA~~ 4!5-0- 55 /A3960O 0Q A C.-F A

Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells.

PubMed

Kobayashi, Masakatsu; Taniura, Hideo; Yoshikawa, Kazuaki

2002-11-01

Necdin is expressed predominantly in postmitotic neurons, and ectopic expression of this protein strongly suppresses cell growth. Necdin has been implicated in the pathogenesis of Prader-Willi syndrome, a human neurodevelopmental disorder associated with genomic imprinting. Here we demonstrate that ectopic expression of necdin induces a neuronal phenotype in neuroblastoma cells. Necdin was undetectable in mouse neuroblastoma N1E-115 cells under undifferentiated and differentiated conditions. N1E-115 cells transfected with necdin cDNA showed morphological differentiation such as neurite outgrowth and expression of the synaptic marker proteins synaptotagmin and synaptophysin. In addition, Western blot analysis of the retinoblastoma protein (Rb) family members Rb, p130, and p107 revealed that necdin cDNA transfectants contained an increased level of p130 and a reduced level of p107, a pattern seen in differentiated G(0) cells. The transcription factors E2F1 and E2F4 physically interacted with necdin via their carboxyl-terminal transactivation domains, but only E2F1 abrogated necdin-induced growth arrest and neurite outgrowth of neuroblastoma cells. Overexpression of E2F1 in differentiated N1E-115 cells induced apoptosis, which was antagonized by co-expression of necdin. These results suggest that necdin promotes the differentiation and survival of neurons through its antagonistic interactions with E2F1.

Flight Problems, Problems in Starting Service,

DTIC Science & Technology

1977-01-03

h i l e a t the same time preserving hi gh f l i g h t r egu la r i t~ l e a d s to t h e fa c t t h a t the t e c h n i cal s t a r t i n g... assembl ies and pa r t s of the a i r c r a f t d~ein the previous flight (R R ), the p r o b a b i l i t y of4pr esence in the landing airport of an...of the assemblies , sets and blocks /P.- can be exchange d in a single hour in case of defects. Furthermore , in the newly constructed L-lOll

Response Protocol Toolbox: Planning for and Responding to Drinking Water Contamination Threats and Incidents. Response Guidelines

DTIC Science & Technology

2004-08-01

sp ec if ic ra d io n u cl id es 9 0 0 S er ie s 3 2 In te ri m F in al – A u g u st 2 0 0 4 R E S...in je ct io n , h ea d sp ac e S ee M o d u le 4 A n a ly si s: G C /M S , G C , H P L C , L C -M S U n k n o w n in o rg an ic s 1 L...er f o r th e m et er o r k it u se d d u ri n g s

Stimulated electromagnetic emission and plasma line during pump wave frequency stepping near 4th electron gyroharmonic at HAARP

NASA Astrophysics Data System (ADS)

Grach, Savely; Sergeev, Evgeny; Shindin, Alexey; Mishin, Evgeny; Watkins, Brenton

Concurrent observations of stimulated (secondary) electromagnetic emissions (SEE) and incoherent plasma line (PL) backscatter from the MUIR radar during HF pumping of the ionosphere by the HAARP heating facility (62.4(°) °N, 145.15(°) W, magnetic inclination α = 75.8^circ) with the pump wave (PW) frequency sweeps about the fourth electron gyroharmonic (4f_c) are presented. The PW frequency f0 was changed every 0.2 s in a 1-kHz step, i.e. with the rate of r_{f_0}=5 kHz/s. PW was transmitted at the magnetic zenith (MZ). Prior to sweeping, PW was transmitted continuously (CW) during 2 min at f_0 = 5730 kHz <4f_c to create the “preconditioned” ionosphere with small-scale magnetic field-aligned irregularities. During CW pumping, a typical SEE spectrum for f_0<4f_c, containing the prominent downshifted maxiμm (DM) shifted by Delta f_{DM} = f_{DM}-f_0approx-9 kHz, developed in 5-10 s after PW turn on. The PL echoes were observed during 2-3 s from the range dsim 220 km corresponding to the altitude slightly above PW reflection height. After sim5 s the PL echoes descended to dsim 210-212 km corresponding to the height h = d / (sinalpha) by sim 7 km below the height where f_0 = 4f_c. During frequency sweeps, two upshifted features appeared in the SEE spectrum for f_0> 4f_c, namely BUM_S and BUM_D. The former (stationary broad upshifted maxiμm) peaks at Delta f_{BUMs} approx f0 - nfc (d) + 15-20 kHz and is a typical SEE spectral feature. The latter, the dynamic BUM_D at smaller Delta f, is observed only at high pump powers (ERP=1.7 GW) and corresponds to artificial descending plasma layers created in the F-region ionosphere [1]. In the experiment in question, the BUM_D was present for f_0> f^*, where f^* was 5805-5815 kHz during stepping up and sim 10 kHz less for stepping down, and located 8-10 km below the background F-layer. The miniμm DM which indicated that f_0=4f_c=f_{uh} in the background ionospheric plasma, was sim 5760 kHz. The PL was observed only for f_0< f^* and mainly from altitudes h where f_0 <4f_c. The height h decreased with increasing f_0 in accordance with the altitude dependence 4f_c(h), the difference Delta f_g = f_0 - 4f_c was kept constant during either sweeping up [-(4-8 kHz)] or sweeping down [-(18-22 kHz)]. This corresponds to the difference between the altitude where f_0=4f_c and the PL generation altitude by Delta h sim 1.5-3 km and 7-8 km, respectively. During stepping up, the PL was observed also from the ranges where f_0 > 4f_c. In this case we obtained Delta f_g sim 8-13 kHz corresponding to Delta h sim - 4 km. The PL has never been observed for f_0>f^*$. \\ 1. Sergeev E., Grach S., et al. //Phys. Rev. Lett., 110 (2013), 065002.

The Defense Policy of the Soviet Union

DTIC Science & Technology

1989-08-01

aims, the probable methods of waging armed combat, the tasks to be performed by the Armed Forces, and the measures required for the all-around social ...organ that exercises ultimate decisional authority on all issues of consequence in the Soviet Union. This small body, whose exact size varies slightly...attit) T. Y P E O F E P O R T & M P f tI O C O V E R C O The Defense Policy of the Soviet Union interim 4. PERFORMING ORG. AEPOA1 44juaER 7. Aurimom

75 FR 30051 - Alaska Native Claims Selection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [F-14989-B, F-14989-C, F-14989-E2, F-14989-G2, F-14989-K2, F-14989-L2; LLAK965000-L14100000-KC0000-P] Alaska Native Claims Selection AGENCY: Bureau of Land Management, Interior. ACTION: Notice of decision approving lands for conveyance. SUMMARY: As...

Novel molecular targets for kRAS downregulation: promoter G-quadruplexes

DTIC Science & Technology

2016-11-01

conditions, and described the structure as having mixed parallel/anti-parallel loops of lengths 2:8:10 in the 5’-3’ direction. Using selective small...and anti-parallel loop directionality of lengths 4:10:8 in the 5’–3’ direction, three tetrads stacked, and involving guanines in runs B, C, E, and F...a tri-stacked structure incorporating runs B, C, E and F with intervening loops of 2, 10, and 8 bases in the 5’–3’ direction. G = black circles, C

Studies of the Origin and Evolution of Ionospheric Irregularities and Their Effects on AF Systems

DTIC Science & Technology

2008-06-30

34The JB2006 empirical thermospheric density model," by B . R. Bowman, W. K . Tobiska, F. A. Marcos, and C. E. Valladares, J. Atm. and Solar-Terr...during the super geomagnetic storm on 20 November 2003, Ann. Geophys, 25, 863-873, 2007. Bowman, B . R., W. K . Tobiska, F. A. Marcos, and C. E...at middle and equatorial latitudes, J. Geophys. Res., 106, 30,389. Devasia, C. V., N. Jyoti, K . S. V. Subbarao , K . S. Viswanathan, D. Tiwari, and R

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 2 (B502-J066)

DTIC Science & Technology

1990-01-01

U 0 V ) V ( w~~~~ ae a11 - 4 W 4 0~~~~ a a4 " A 0 1> z~~~~ a. a0 4 0 4 1 4 ,0 4 - 4a%- %. 0 4a4 t4 i acca Lu awHIu 0a 0 0 0 Iw awa In InI I IK t0 n 4...f0 <z 1. 0 m) 1-4 w 0 .0 0 ) 0 w ’ -J z U) 1-- -- &a x -- m < I z w z 0 F- or. o LU c-c, J O "I- "I- 11-1 0 F1 {A - " " :)ix [ I-- . U H E (. 0 ’ C3...I Ir 10 0 10 - U I I CO F1 4 04 U 40 40 IWI O 4 -~ ~ ~ OF- ~ 1 Z E c’) a Sc 0 00 -4 𔃺 0 U) SO (a e UL N 4 q 0 -4 1 -tr N (0 0) r, (a L0 m w) m 0 -t

FAA Air Traffic Activity

DTIC Science & Technology

1992-09-01

d, 0 U 0 E-4- 1-4 p/7. .4 H, , , I I F T 1 1 I1 - - B1 -4 c nI a W I~ 0" Q o6 0G 0 00 24 Q N~nIn 1--- U 00 :C% F’-4 -. 07 ;T4 LIn E1-6 TABLE 1-5 30...0 RUGBY ................................... ........................... ND N ZMP 43 0 0 42 1 RUSHFORD MUNICIPAL ..................... MN N ZMP 1 0 0

Solid State Research, 1975:3

DTIC Science & Technology

1975-08-15

Heckscher T. F. Deutsch H. Kildal D. L. Spears I. Melngailis T. C. Haiman P. L. Kelley R. S. Eng D. L. Spears H. R. Fetterman H. R... Fetterman H. R. Schlossberg* W. E. Barch 1975 International IEEE/APS Symposium and USNC/URSI Meeting, Urbana, Illinois, 4 June 1975 * Author not...ft. Chinn, S. R. Del-eo, ft. E. Deutsch, T. F. Fetterman , II. R. Hancock, R. C. II. Ileckscher, Kildal, II. Larsen, D. M. Mandel, P

Molecular Determinants for Antibody Binding on Group 1 House Dust Mite Allergens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chruszcz, Maksymilian; Pomés, Anna; Glesner, Jill

2012-07-11

House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE responses in 80% of mite-allergic subjects and have proinflammatory properties. Their antigenic structure is unknown. Here, we present crystal structures of natural Der p 1 and Der f 1 in complex with a monoclonal antibody, 4C1, which binds to a unique cross-reactive epitope on both allergens associated with IgE recognition. The 4C1 epitope is formed by almost identical amino acid sequences and contact residues. Mutations of the contactmore » residues abrogate mAb 4C1 binding and reduce IgE antibody binding. These surface-exposed residues are molecular targets that can be exploited for development of recombinant allergen vaccines.« less

Systems Engineering Measurement Primer

DTIC Science & Technology

1998-03-01

Schermerhorn , R ., “Determining metrics for...maintenance process. 12 S e l e c t a n d S p e c i f y M e a s u r e s a n d I n d i c a t o r s C o l l e c t D a t a C a l c u l a t e I n d i c a...t o r s A n a l y z e t h e M e a s u r e s o r I n d i c a t o r s R e p o r t a n d U s e t h e R e s u l t s Issues Goals Risks A

Organization of photosystem I polypeptides examined by chemical cross-linking

NASA Technical Reports Server (NTRS)

Armbrust, T. S.; Chitnis, P. R.; Guikema, J. A.; Spooner, B. S. (Principal Investigator)

1996-01-01

Photosystem I from the cyanobacterium Synechocystis sp. PCC 6803 was examined using the chemical cross-linkers glutaraldehyde and N-ethyl-1-3-[3-(dimethylamino)propyl]carbodiimide to investigate the organization of the polypeptide subunits. Thylakoid membranes and photosystem I, which was isolated by Triton X-100 fractionation, were treated with cross-linking reagents and were resolved using a Tricine/urea low-molecular-weight resolution gel system. Subunit-specific antibodies and western blotting analysis were used to identify the components of cross-linked species. These analyses identified glutaraldehyde-dependent cross-linking products composed of small amounts of PsaD and PsaC, PsaC and PsaE, and PsaE and PsaF. The novel cross-link between PsaE and PsaF was also observed following treatment with N-ethyl-1-3-[3-(dimethylamino)propyl]carbodiimide. These cross-linking results suggest a structural interaction between PsaE and PsaF and predict a transmembrane topology for PsaF.

Investigation of a Cesium Raman Time/Frequency Standard

DTIC Science & Technology

1991-12-01

0. 1 4 XZ E(r, t) = ’h/(El(r)exp(- iwlt ) + c.c.) 0 + ’/,(E 2(r)exp(- iw.2t) + c.c.). (2) - /2 eAll remaining notations are defined in Table 1. By...h P - P33 Rabi frequency for 3-2 transition 92 = 623 E2 )/h [ [r Rotating-wave (a~~012 = P12 exp(- iwlt ) S 0 0i 2Ra 1 1f2sRotating-wav e a,3 2 e p(-i

Development of an EEG Artifact Correction Device

DTIC Science & Technology

1990-04-16

30424, 30273, 30117, 29956, 29791 0544 8573077354729071 272 DCW 29621, 29447, 29268, 29085, 28898, 28706 0550 5E6F966EC960F86C 273 DCW 28510, 28310...29621, - 29791 0688 FC8A588ABF892889 303 DCW -29956, -30117, -30273, -30424, -30571, -30714 06C4 7C87F7867786FB85 304 DCW -30852, -30985, -31113...313 DCW -31113, -30985, -30852, -30714, -30571, -30424 073C BF895B8AFC8AA18B 314 DCW -30273, -30117, -29956, - 29791 , -29621, -29447 0748

Effects of Al content and annealing on the phases formation, lattice parameters, and magnetization of A lxF e2B2 (x =1.0 ,1.1 ,1.2 ) alloys

NASA Astrophysics Data System (ADS)

Levin, E. M.; Jensen, B. A.; Barua, R.; Lejeune, B.; Howard, A.; McCallum, R. W.; Kramer, M. J.; Lewis, L. H.

2018-03-01

AlF e2B2 is a ferromagnet with the Curie temperature around 300 K and has the potential to be an outstanding rare-earth free candidate for magnetocaloric applications. However, samples prepared from the melt contain additional phases which affect the functional response of the AlF e2B2 phase. We report on the effects of Al content in samples with the initial (nominal) composition of A lxF e2B2 , where x =1.0 , 1.1, and 1.2 prepared by arc-melting followed by suction casting and annealing. The as-cast A lxF e2B2 alloys contain AlF e2B2 as well as additional phases, including the primary solidifying FeB and A l13F e4 compounds, which are ferromagnetic and paramagnetic, respectively, at 300 K. The presence of these phases makes it difficult to extract the intrinsic magnetic properties of AlF e2B2 phase. Annealing of A lxF e2B2 alloys at 1040 °C for 3 days allows for reaction of the FeB with A l13F e4 to form the AlF e2B2 phase, significantly reduces the amount of additional phases, and results in nearly pure AlF e2B2 phase as confirmed with XRD, magnetization, scanning electron microscopy, and electronic transport. The values of the magnetization, effective magnetic moment per Fe atom, specific heat capacity, electrical resistivity, and Seebeck coefficient for the AlF e2B2 compound have been established.

U.S. EPA, Pesticide Product Label, GRASLAN BRUSH BULLETS 125, 01/13/1983

EPA Pesticide Factsheets

2011-04-14

... r!af"S ;'OP', f· q"l ClnA~LAN E·l.~'" t~~. etc; ':" ·l::n ..... f;' "'J'-o( ~ ,': f:f Il{'f '1"'0 ~"!~.J,ll '''''d. c'aT'1 Ol.! "n rr',:'e Ina"'':O \\.")R",S'-A~. BII.~" t~" j'::;' ...

Analysis of hRad1, a Human G2 Checkpoint Control Gene

DTIC Science & Technology

2002-03-01

kinases chk1(+) and cds1(+). Genetics, 1999. 152(4): p. 1501-12. 39. Fritz , E., A.A. Friedl, R.M. Zwacka, F. Eckardt-Schupp, and M.S. Meyn, The yeast...Schiripo, M.M. Jorczak, D.C. Sgroi, J.E. Garber, F.P. Li, K.E. Nichols, J.M. Varley, A.K. Godwin, K.M. Shannon, E. Harlow, and D.A. Haber

Developing Treatment, Treatment Validation, and Treatment Scope in the Setting of an Autism Clinical Trial

DTIC Science & Technology

2013-06-01

neurodevelopmental disorders 3(2): 132-143. Buyske, S., T. A. Williams, A. E. Mars, E. S. Stenroos, S. X. Ming, R. Wang, M. Sreenath, M. F. Factura , C. Reddy, G. H...Gastroenterol Nutr. Williams, T. A., A. E. Mars, S. G. Buyske, E. S. Stenroos, R. Wang, M. F. Factura -Santiago, G. H. Lambert and W. G. Johnson (2007

Inter-serotype comparison of polysaccharides produced by extracellular enzymes from Streptococcus mutans.

PubMed

Yakushiji, T; Inoue, M; Koga, T

1984-04-15

The biochemical and morphological characteristics of polysaccharides synthesized from sucrose by extracellular enzymes from D-glucose-grown Streptococcus mutans representing serotypes a-g were compared. The polysaccharides synthesized by the enzymes from serotypes a, d, and g formed visible aggregates and firmly adhered to glass surfaces, whereas those formed by the enzymes from serotypes b, c, e, and f floated homogeneously and were poorly adherent. The enzymes of serotypes a, d, and g produced large amounts of water-insoluble polysaccharides (IPs, D-glucans), and those of serotypes b, c, e, and f water-soluble polysaccharides (SPs, D-glucans and D- fructans ). As compared with the IPs of serotypes b, c, e, and f, the IPs of serotypes a, d, and g (a) contained a higher proportion of (1----3)-alpha-D-glucosidic linkages and alpha-D-(1----3,6) branch linkages; (b) showed higher susceptibility to (1----3)-alpha-D-glucanase (serotype a excepted) and lower (1----6)-alpha-D-glucanase sensitivity; (c) contained larger amounts of high-molecular-weight fractions; (d) showed higher intrinsic viscosities (serotype b excepted); and (e) had lower S. mutans cell-agglutination activities. On electron-microscope observation, the IPs of all serotypes showed two fibrillar components; a double-stranded fibril, with short, fluffy protrusions extending out of its periphery, and a fine, single-stranded fibril. Thus, the serotypes could be divided into two major groups: a, d, and g; and b, c, e, and f. No similar grouping of serotypes was indicated by the chemical and morphological properties of SPs.

Identification of a Cullin5-ElonginB-ElonginC E3 complex in degradation of feline immunodeficiency virus Vif-mediated feline APOBEC3 proteins.

PubMed

Wang, Jiawen; Zhang, Wenyan; Lv, Mingyu; Zuo, Tao; Kong, Wei; Yu, Xianghui

2011-12-01

Various feline APOBEC3 (fA3) proteins exhibit broad antiviral activities against a wide range of viruses, such as feline immunodeficiency virus (FIV), feline foamy virus (FFV), and feline leukemia virus (FeLV), as well as those of other species. This activity can be counteracted by the FIV Vif protein, but the mechanism by which FIV Vif suppresses fA3s is unknown. In the present study, we demonstrated that FIV Vif could act via a proteasome-dependent pathway to overcome fA3s. FIV Vif interacted with feline cellular proteins Cullin5 (Cul5), ElonginB, and ElonginC to form an E3 complex to induce degradation of fA3s. Both the dominant-negative Cul5 mutant and a C-terminal hydrophilic replacement ElonginC mutant potently disrupted the FIV Vif activity against fA3s. Furthermore, we identified a BC-box motif in FIV Vif that was essential for the recruitment of E3 ubiquitin ligase and also required for FIV Vif-mediated degradation of fA3s. Moreover, despite the lack of either a Cul5-box or a HCCH zinc-binding motif, FIV Vif specifically selected Cul5. Therefore, FIV Vif may interact with Cul5 via a novel mechanism. These finding imply that SOCS proteins may possess distinct mechanisms to bind Cul5 during formation of the Elongin-Cullin-SOCS box complex.

The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal.

PubMed

Wang, Xiangyu; Du, Yanli; Hua, Ying; Fu, Muqing; Niu, Cong; Zhang, Bao; Zhao, Wei; Zhang, Qiwei; Wan, Chengsong

2017-01-01

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, Δ espF ), N-terminal sequence (219 bp, Δ espF N ), and C-terminal sequence (528 bp, Δ espF C ) separately using the pKD46-mediated λ Red homologous recombination system. Then, we built the corresponding complementation strains, namely, Δ espF/pespF , Δ espF N /pespF N , and Δ espF C /pespF C by overlap PCR, which were used in infecting HT-29 cells and BALB/C mice. The level of reactive oxygen species, cell apoptosis, mitochondrial trans-membrane potential, inflammatory factors, transepithelial electrical resistance (TER), and animal mortality were evaluated by DCFH-DA, double staining of Annexin V-FITC/PI, JC-1 staining, ELISA kit, and a mouse assay. The wild-type (WT), Δ espF , Δ espF/pespF , Δ espF C , Δ espF C /pespF C , Δ espF N , and Δ espF N /pespF N groups exhibited apoptotic rates of 68.3, 27.9, 64.9, 65.7, 73.4, 41.3, and 35.3% respectively, and mean TNF-α expression levels of 428 pg/mL, 342, 466, 446, 381, 383, and 374 pg/mL, respectively. In addition, the apoptotic rates and TNF-α levels of the WT, Δ espF/pespF , and Δ espF C were significantly higher than that of Δ espF , Δ espF N , Δ espF C /pespF C , and Δ espF N /pespF N group ( p < 0.05). The N-terminal of EspF resulted in an increase in the number of apoptotic cells, TNF-α secretion, ROS generation, mitochondria apoptosis, and pathogenicity in BalB/c mice. In conclusion, the N-terminal domain of the Enterohemorrhagic E. coli O157:H7 EspF more strongly promotes apoptosis and inflammation than the C-terminal domain.

Unification of Electromagnetic Specifications and Standards. Part 2. Recommendations for Revisions of Existing Practices

DTIC Science & Technology

1983-02-28

tire, .v ,.,, DNA 5433F-2 I 1 UNIFICATION OF ELECTROMAGNETIC -’, SPECIFICATIONS AND STANDARDS Part Ih: Recommendations for Revisions of Existing...ADDRESSEE IS NO LONGER EMPLOYED BY" "• YOUR ORGANIZATION. ... : 1 ,S ::! ,.S ., UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When D.e. 6.e1e..c...REPORT DOCUMENTATION PAGE BEFORE COMPETISRM 1 . REPORT NUMBER 2. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER DNA 5433F-2 1 /f9 I;’,71 4. TITLE

The INTERLISP Virtual Machine Specification,

DTIC Science & Technology

1976-09-01

typescript ” files. t h i n _ r b is. f i les contain -sung all ofthen i n n _ p m_ n_ b n_ u n _ l~m m : t tm , u i n _ :- , u - n_ h i On s w i t h...nm _ sIn _ c d of a File N~n _ mune ) n_ n _ u u ’J t b - s e nann_e of tb;e current , - typescript file (i f n _ n _ n _ n y). The conrespondunmg f

Inhibition of cholinesterase activity by extracts, fractions and compounds from Calceolaria talcana and C. integrifolia (Calceolariaceae: Scrophulariaceae).

PubMed

Cespedes, Carlos L; Muñoz, Evelyn; Salazar, Juan R; Yamaguchi, Lydia; Werner, Enrique; Alarcon, Julio; Kubo, Isao

2013-12-01

Extracts, fractions and compounds from Calceolaria talcana and C. integrifolia exhibited strong inhibitory effects of the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes using the in vitro Ellman's method. The most active samples were from the ethyl acetate extract, which caused a mixed-type inhibition against AChE (69.8% and 79.5% at 100 and 200 μg/ml, respectively) and against BChE (98.5% and 99.8% at 100 and 200 μg/ml, respectively) and its major components verbascoside 8 (50.9% and 70.0% at 200 μg/ml, against AChE and BChE, respectively), martynoside 9, and fraction F-7 (which corresponds to a mixture of 8, 9, and other phenylethanoids and phenolics that remain unidentified) (80.2% and 85.3% at 100 and 200 μg/ml, against AChE, respectively and 99.1% and 99.7% at 100 and 200 μg/ml, against BChE, respectively) inhibited the acetylcholinesterase enzyme competitively. The most polar fraction F-5 from n-hexane extract (a mixture of naphthoquinones: 2-hydroxy-3-(1,1-dimethylallyl-1,4-naphthoquinone) 6, α-dunnione 7 and other polar compounds that remain unidentified) showed a mixed-type inhibition (71.5% and 72.1% against AChE and BChE at 200 μg/ml, respectively). Finally, the methanol-soluble residue presented a complex, mixed-type inhibition (39.9% and 67.9% against AChE and BChE at 200 μg/ml, respectively). The mixture F-3 with diterpenes was obtained from the n-hexane extract: (1,10-cyclopropyl-9-epi-ent-isopimarol) 1, 19-α-hydroxy-abietatriene 2, and F-4 a mixture of triterpenes α-lupeol 3, β-sitosterol 4, ursolic acid 5 together with a complex mixture of terpenes that did not show activity. In summary, extracts and natural compounds from C. talcana and C. integrifolia were isolated, identified and characterized as cholinesterase inhibitors.

Alternative Sigma Factors SigF, SigE, and SigG Are Essential for Sporulation in Clostridium botulinum ATCC 3502

PubMed Central

Kirk, David G.; Zhang, Zhen; Korkeala, Hannu

2014-01-01

Clostridium botulinum produces heat-resistant endospores that may germinate and outgrow into neurotoxic cultures in foods. Sporulation is regulated by the transcription factor Spo0A and the alternative sigma factors SigF, SigE, SigG, and SigK in most spore formers studied to date. We constructed mutants of sigF, sigE, and sigG in C. botulinum ATCC 3502 and used quantitative reverse transcriptase PCR and electron microscopy to assess their expression of the sporulation pathway on transcriptional and morphological levels. In all three mutants the expression of spo0A was disrupted. The sigF and sigE mutants failed to induce sigG and sigK beyond exponential-phase levels and halted sporulation during asymmetric cell division. In the sigG mutant, peak transcription of sigE was delayed and sigK levels remained lower than that in the parent strain. The sigG mutant forespore was engulfed by the mother cell and possessed a spore coat but no peptidoglycan cortex. The findings suggest that SigF and SigE of C. botulinum ATCC 3502 are essential for early sporulation and late-stage induction of sigK, whereas SigG is essential for spore cortex formation but not for coat formation, as opposed to previous observations in B. subtilis sigG mutants. Our findings add to a growing body of evidence that regulation of sporulation in C. botulinum ATCC 3502, and among the clostridia, differs from the B. subtilis model. PMID:24928875

Uniform sparse bounds for discrete quadratic phase Hilbert transforms

NASA Astrophysics Data System (ADS)

Kesler, Robert; Arias, Darío Mena

2017-09-01

For each α \\in T consider the discrete quadratic phase Hilbert transform acting on finitely supported functions f : Z → C according to H^{α }f(n):= \\sum _{m ≠ 0} e^{iα m^2} f(n - m)/m. We prove that, uniformly in α \\in T , there is a sparse bound for the bilinear form < H^{α } f , g > for every pair of finitely supported functions f,g : Z→ C . The sparse bound implies several mapping properties such as weighted inequalities in an intersection of Muckenhoupt and reverse Hölder classes.

[Experimental study on avascular necrosis of femoral head in chickens induced by different glucocorticoides].

PubMed

Xiao, Chun-Sheng; Lin, Na; Lin, Shi-Fu; Wan, Rong; Chen, Wei-Heng

2010-03-01

To study the effects of Methylprednisolone and Dexamethasone on the avascular necrosis of femoral head in chickens. Thirty-six chickens were randomly divided into 6 groups (n = 6): control group (group A), Methylprednisolone low dose group (group B), Methylprednisolone large dose group (group C), small dose Dexamethasone and horse serum group (group D), middle dose Dexamethasone and horse serum group (group E), and Dexamethasone large dose group (group F). On the 6th and 12th weeks, blood samples were obtained to determine the level of total cholesterol triglyeride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). On the 12th week, femoral heads were taken off. Paraffin tissue sections were prepared to detect histopathologic change with hematoxylin and eosin staining. On the 6th week, compared with group A, the level of CHO increased significantly in group C and group F (P < 0.05), and TG increased in group B, C and group E, while HDL decreased in group B, C and group E. On the 12th week, the level of TG and CHO increased in group B, C, E and group F, and HDL decreased in group C, D and group E (P < 0.05). LDL was not detected in most chickens. The ratio of empty lacuna was higher in group C and group E compared with those of the control group (P < 0.05). Methylprednisolone is easier to induce osteonecrosis of femoral head than Dexamethasone. The condition of metabolic disorder in blood may be the basic pathomechanism of steroid-induced necrosis of femoral head.

Measurement of the longitudinal, transverse, and longitudinal-transverse structure functions in the {sup 2}H({ital e},{ital e}{prime}{ital p}){ital n} reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jordan, D.; McIlvain, T.; Alarcon, R.

1996-03-01

We have separated the longitudinal ({ital f}{sub 00}), transverse ({ital f}{sub 11}), and longitudinal-transverse interference ({ital f}{sub 01}) structure functions in the {sup 2}H({ital e},{ital e}{prime}{ital p}){ital n} reaction at {ital q}{searrow}{parallel}{approx_equal} 400 MeV/{ital c} and {omega}{approx_equal}110 MeV. A nonrelativistic calculation which includes effects due to final state interactions, meson exchange currents, and isobar configurations agrees with the measured {ital f}{sub 11} and {ital f}{sub 01} but overpredicts {ital f}{sub 00} by 25{percent} (2{sigma}). The data are also compared to the results of previous structure function measurements. {copyright} {ital 1996 The American Physical Society.}

Chemical Reactions at the Au/InP Interface.

DTIC Science & Technology

1986-10-15

Chye , et al., 6 using various forms of photoemission spectroscopy and ion-depth profiling techniques, found that extremely thin Au films 3 interacted...Appl. Phys. 50, 1445 (1979). 6) P.W. ChYe , I. Lindau, P. Pianetta, Ci’!. Garner, C.Y. Su and W.E. Spicer, Physical Review B, 19, 5545 (1978). 7) R.F.C...Brilison, C.F. Brucker, A.D. Katnani, N.G. Stoffel, and G. Margaritondo, J.Vac.Soi Technol., 19, 661 (1981). 13) 1. Caznlibel, A.K. Chin , F. Eruanis

Selection of Dimensions for an Anthropometric Data Base. Volume 2. Dimension Evaluation Sheets

DTIC Science & Technology

1986-05-30

RATING IN D IS: This dimension has not been identified as being useful for engineering anthropometry . F. RACE SENSITIVE? YES F-i NO Ffl GENDER SENSITIVE...SENSITIVE? YES NO[ Xl IN WHAT WAY? G. REPRODUCIBILITY: A f-W B [] C E-1 IF B OR C, THE PROBLEM IS: H. PARTICULARLY SENSITIVE FO: identification of...Marginal VALUE FOR A U.S. ARMY ANTHROPOMETRIC DATA BASE. D. REASON FOR RATING IN C ISf there is no engineering anthropometry application for this

Determination of the equation parameters of carbon flow curves and estimated carbon flow and CO2 emissions from broiler production.

PubMed

Henn, J D; Bockor, L; Borille, R; Coldebella, A; Ribeiro, A M L; Kessler, A M

2015-09-01

The objective of this study was to determine the equation parameters of carbon (i.e., C) flow curves and to estimate C flow and carbon dioxide (i.e., CO2) emissions from the production of 1- to 49-day-old broilers from different genetic strains. In total, 384 1-day-old chicks were used, distributed into 4 groups: high-performance males (Cobb-M) and females (Cobb-F), and intermediate-performance males (C44-M) and females (C44-F), with 6 replicates/treatment according to a completely randomized study design. Carbon intake and retention were calculated based on diet and body C composition, and expired C was stoichiometrically estimated as digestible C intake-C retention-C in the urine. Litter C emission was estimated as initial litter C+C in the excreta-final litter C. Carbon flow curves were determined fitting data by nonlinear regression using the Gompertz function. Expired CO2 was calculated based on expired C. The applied nonlinear model presented goodness-of-fit for all responses (R2>0.99). Carbon dioxide production was highly correlated with growth rate. At 42 d age, CO2 expiration (g/bird) was 3,384.4 for Cobb-M, 2,947.9 for Cobb-F, 2,512.5 for C44-M, and 2185.1 for C44-F. Age also significantly affected CO2 production: to achieve 2.0 kg BW, CO2 expiration (g/bird) was 1,794.3 for Cobb-M, 2,016.5 for Cobb-F, 2617.7 for C44-M, and 3,092.3 for C44-F. The obtained equations present high predictability to estimate individual CO2 emissions in strains of Cobb and C44 broilers of any weight, or age, reared between 1 and 49 d age. © 2015 Poultry Science Association Inc.

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

Measurement of Compression Factor and Error Sensitivity Factor of Facsimile Coding Techniques Submitted to the CCITT By Great Britain and the Federal Republic of Germany

DTIC Science & Technology

1979-10-01

D CD I- l M C’ m (’-01 V-~ "r c ml C- 00 0 v ~ ~ v V. v vCvq; o LO tol vo oo Co Lo 0 tD CI C CO U) 0 -4 l m1C’ .4oC cn z m’N t’l - ccC l m Z o .- 4C t...00013 IrTA 11 F j~)f~, I)~ l53 t.l .. AsOOM lf DATA CJ-3.(to S.1)sCODE(29 591)vCO0E(3s 5o11/ 49 b#ZOOOB/ 00013 DATA COJE(A. 69l)oC30E(29 691)*CCDE-(39...nn~i-,, ~.2 2-LCJM - 1 A, A -AI .DREfr Td ~ 92It 61 - ff~ *CTABLEW(16).CSTART(16).STBUF(1728JSrRUN(1728) 00004i C0MMOC4.E4iAY /ERROR S( 25001 00004

Fragmentation patterns of multicharged C60r+ (r=3-5) studied with well-controlled internal excitation energy

NASA Astrophysics Data System (ADS)

Martin, S.; Chen, L.; Salmoun, A.; Li, B.; Bernard, J.; Brédy, R.

2008-04-01

We have studied the relaxation of triply charged C60 obtained in collisions F2++C60→F-+C603+∗ at low impact energy (E=6.8keV) . Depending on the excitation energy, these initial parent ions decay following a variety of channels, such as thermal electronic ionization, evaporation of C2 units, asymmetrical fission, and multifragmentation. Using a recently developed experimental method, named collision-induced dissociation under energy control, we were able to measure the energy deposited in C603+∗ for each collision event and to obtain an excitation energy profile of the parent ions associated with each decay channel. In our chosen observation time scale of the order of 1μs , evaporations and asymmetrical fissions of C603+,4+ occur when the internal energy is in the range from 40 to 100 eV. The multifragmentation becomes dominant for multicharged C604+,5+ parent ions from 100 to 210 eV. In the case of C604+ , the multifragmentation channel is opened at low energy (40 eV). Therefore, in the energy range 40-100 eV, the asymmetrical fission, evaporation, and multifragmentation channels are in competition.

Cluster of Genes That Encode Positive and Negative Elements Influencing Filament Length in a Heterocyst-Forming Cyanobacterium

PubMed Central

Merino-Puerto, Victoria; Herrero, Antonia

2013-01-01

The filamentous, heterocyst-forming cyanobacteria perform oxygenic photosynthesis in vegetative cells and nitrogen fixation in heterocysts, and their filaments can be hundreds of cells long. In the model heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120, the genes in the fraC-fraD-fraE operon are required for filament integrity mainly under conditions of nitrogen deprivation. The fraC operon transcript partially overlaps gene all2395, which lies in the opposite DNA strand and ends 1 bp beyond fraE. Gene all2395 produces transcripts of 1.35 kb (major transcript) and 2.2 kb (minor transcript) that overlap fraE and whose expression is dependent on the N-control transcription factor NtcA. Insertion of a gene cassette containing transcriptional terminators between fraE and all2395 prevented production of the antisense RNAs and resulted in an increased length of the cyanobacterial filaments. Deletion of all2395 resulted in a larger increase of filament length and in impaired growth, mainly under N2-fixing conditions and specifically on solid medium. We denote all2395 the fraF gene, which encodes a protein restricting filament length. A FraF-green fluorescent protein (GFP) fusion protein accumulated significantly in heterocysts. Similar to some heterocyst differentiation-related proteins such as HglK, HetL, and PatL, FraF is a pentapeptide repeat protein. We conclude that the fraC-fraD-fraE←fraF gene cluster (where the arrow indicates a change in orientation), in which cis antisense RNAs are produced, regulates morphology by encoding proteins that influence positively (FraC, FraD, FraE) or negatively (FraF) the length of the filament mainly under conditions of nitrogen deprivation. This gene cluster is often conserved in heterocyst-forming cyanobacteria. PMID:23813733

Coexistence of ferromagnetism and unconventional spin-glass freezing in the site-disordered kagome ferrite SrS n2F e4O11

NASA Astrophysics Data System (ADS)

Shlyk, L.; Strobel, S.; Farmer, B.; De Long, L. E.; Niewa, R.

2018-02-01

Single-crystal x-ray diffraction refinements indicate SrS n2F e4O11 crystallizes in the hexagonal R -type ferrite structure with noncentrosymmetric space group P 63m c and lattice parameters a =5.9541 (2 )Å , c =13.5761 (5 )Å , Z =2 (R (F )=0.034 ). Octahedrally coordinated 2 a [M (1) and M (1a)] and 6 c sites [M (2 )] have random, mixed occupation by Sn and Fe; whereas the tetrahedrally coordinated 2 b sites [Fe(3) and Fe(3a)] are exclusively occupied by Fe, whose displacement from the ideal position with trigonal-bipyramidal coordination causes the loss of inversion symmetry. Our dc and ac magnetization data indicate SrS n2F e4O11 single crystals undergo a ferro- or ferri-magnetic transition below a temperature TC=630 K with very low coercive fields μoHc ⊥=0.27 Oe and μoHc ∥=1.5 Oe at 300 K, for applied field perpendicular and parallel to the c axis, respectively. The value for TC is exceptionally high, and the coercive fields exceptionally low, among the known R-type ferrites. Time-dependent dc magnetization and frequency-dependent ac magnetization data indicate the onset of short-range, spin-glass freezing below Tf=35.8 K , which results from crystallographic disorder of magnetic F e3 + and nonmagnetic S n4 + ions on a frustrated Kagome sublattice. Anomalous ac susceptibility and thermomagnetic relaxation behavior in the short-range-ordered state differs from that of conventional spin glasses. Optical measurements in the ultraviolet to visible frequency range in a diffuse reflectance geometry indicate an overall optical band gap of 0.8 eV, consistent with observed semiconducting properties.

Protection with Recombinant Clostridium botulinum C1 and D Binding Domain Subunit (Hc) Vaccines Against C and D Neurotoxins

DTIC Science & Technology

2007-03-16

A p o p f b a © K 1 c s r h a d t f f r i 0 d Vaccine 25 (2007) 4273–4282 Protection with recombinant Clostridium botulinum C1 and D binding domain...reserved. r-bindin s r t r w i t l s eywords: Botulinum neurotoxin subtypes; Recombinant vaccine; Recepto . Introduction Botulism is the collective term...amedd.army.mil (L.A. Smith). e c t B i T c s 264-410X/$ – see front matter © 2007 Elsevier Ltd. All rights reserved. oi:10.1016/j.vaccine

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

PubMed Central

Bandara, L R; Buck, V M; Zamanian, M; Johnston, L H; La Thangue, N B

1993-01-01

It is widely believed that the cellular transcription factor DRTF1/E2F integrates cell cycle events with the transcription apparatus because during cell cycle progression in mammalian cells it interacts with molecules that are important regulators of cellular proliferation, such as the retinoblastoma tumour suppressor gene product (pRb), p107, cyclins and cyclin-dependent kinases. Thus, pRb, which negatively regulates early cell cycle progression and is frequently mutated in tumour cells, and the Rb-related protein p107, bind to and repress the transcriptional activity of DRTF1/E2F. Viral oncoproteins, such as adenovirus E1a and SV40 large T antigen, overcome such repression by sequestering pRb and p107 and in so doing are likely to activate genes regulated by DRTF1/E2F, such as cdc2, c-myc and DHFR. Two sequence-specific DNA binding proteins, E2F-1 and DP-1, which bind to the E2F site, contain a small region of similarity. The functional relationship between them has, however, been unclear. We report here that DP-1 and E2F-1 exist in a DNA binding complex in vivo and that they bind efficiently and preferentially as a heterodimer to the E2F site. Moreover, studies in yeast and Drosophila cells indicate that DP-1 and E2F-1 interact synergistically in E2F site-dependent transcriptional activation. Images PMID:8223441

Large springs in the United States

USGS Publications Warehouse

Meinzer, Oscar Edward

1927-01-01

What are the largest springs in the United States, how much water do they discharge, and what geologic conditions produce them are questions of much popular interest and considerable scientific and economic importance. Yet the information in regard to large springs has been so widely scattered and so difficult to interpret that most people have only very vague notions on the subject. The present paper is in a sense a by-product of a more comprehensive investigation of the origin, discharge, and quantity of ground water in the United States. It has, however, required, extensive search for data and critical analysis of the data that were obtained. The task would have been virtually impossible except for the hearty cooperation of the district engineers and other members of the water- resources branch of the Geological Survey, who are really coauthors of this paper. I wish to acknowledge especially the help of Kirk Bryan, G. C. Stevens, W. E. Hall, W. E. King, E. L. Williams, H. C. Beckman, C. E. Ellsworth, C. E. McCashin, C. G. Paulsen, W. G. Hoyt, H. T. Stearns, H. D. McGlashan, R. C. Briggs, F. F. Henshaw, W. A. Lamb, G. M. Hall, E. C. LaRue, and A. B. Purton

Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG

PubMed Central

Sun, Ping; Tropea, Joseph E.; Austin, Brian P.; Cherry, Scott; Waugh, David S.

2008-01-01

Summary The plague-causing bacterium Yersinia pestis utilizes a Type III Secretion System (T3SS) to deliver effector proteins into mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. Effector proteins are injected through a hollow needle structure composed of the protein YscF. YscG and YscE act as "chaperones" to prevent premature polymerization of YscF in the cytosol of the bacterium prior to assembly of the needle. Here, we report the crystal structure of the YscEFG protein complex at 1.8 Å resolution. Overall, the structure is similar to that of the analogous PscEFG complex from the Pseudomonas aeruginosa T3SS, but there are noteworthy differences. The structure confirms that, like PscG, YscG is a member of the tetratricopeptide repeat (TPR) family of proteins. YscG binds tightly to the C-terminal half of YscF, implying that it is this region of YscF that controls its polymerization into the needle structure. YscE interacts with the N-terminal TPR motif of YscG but makes very little direct contact with YscF. Its function may be to stabilize the structure of YscG and/or to participate in recruiting the complex to the secretion apparatus. No electron density could be observed for the N-terminal 49 residues of YscF. This and additional evidence suggest that the N-terminus of YscF is disordered in the complex with YscE and YscG. As expected, conserved residues in the C-terminal half of YscF mediate important intra- and intermolecular interactions in the complex. Moreover, the phenotypes of some previously characterized mutations in the C-terminal half of YscF can be rationalized in terms of the structure of the heterotrimeric YscEFG complex. PMID:18281060

Structural Characterization of the Yersinia pestis Type III Secretion System Needle Protein YscF in Complex with Its Heterodimeric Chaperone YscE/YscG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Ping; Tropea, Joseph E.; Austin, Brian P.

2008-05-03

The plague-causing bacterium Yersinia pestis utilizes a type III secretion system to deliver effector proteins into mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. Effector proteins are injected through a hollow needle structure composed of the protein YscF. YscG and YscE act as 'chaperones' to prevent premature polymerization of YscF in the cytosol of the bacterium prior to assembly of the needle. Here, we report the crystal structure of the YscEFG protein complex at 1.8 {angstrom} resolution. Overall, the structure is similar to that of the analogous PscEFG complex from the Pseudomonasmore » aeruginosa type III secretion system, but there are noteworthy differences. The structure confirms that, like PscG, YscG is a member of the tetratricopeptide repeat family of proteins. YscG binds tightly to the C-terminal half of YscF, implying that it is this region of YscF that controls its polymerization into the needle structure. YscE interacts with the N-terminal tetratricopeptide repeat motif of YscG but makes very little direct contact with YscF. Its function may be to stabilize the structure of YscG and/or to participate in recruiting the complex to the secretion apparatus. No electron density could be observed for the 49 N-terminal residues of YscF. This and additional evidence suggest that the N-terminus of YscF is disordered in the complex with YscE and YscG. As expected, conserved residues in the C-terminal half of YscF mediate important intra- and intermolecular interactions in the complex. Moreover, the phenotypes of some previously characterized mutations in the C-terminal half of YscF can be rationalized in terms of the structure of the heterotrimeric YscEFG complex.« less

Energy correction factors of LiF powder TLDs irradiated in high-energy electron beams and applied to mailed dosimetry for quality assurance networks.

PubMed

Marre, D; Ferreira, I H; Bridier, A; Björeland, A; Svensson, H; Dutreix, A; Chavaudra, J

2000-12-01

Absorbed dose determination with thermoluminescent dosimeters (TLDs) generally relies on calibration in 60Co gamma-ray reference beams. The energy correction factor fCo(E) for electron beams takes into account the difference between the response of the TLD in the beam of energy E and in the 60Co gamma-ray beam. In this work, fCo(E) was evaluated for an LiF powder irradiated in electron beams of 6 to 20 MeV (Varian 2300C/D) and 10 to 50 MeV (Racetrack MM50), and its variation with electron energy, TLD size and nature of the surrounding medium was also studied for LiF powder. The results have been applied to the ESTRO-EQUAL mailed dosimetry quality assurance network. Monte Carlo calculations (EGS4, PENELOPE) and experiments have been performed for the LiF powder (rho = 1.4 g cm3) (DTL937, Philitech, France), read on a home made reader and a PCL3 automatic reader (Fimel, France). The TLDs were calibrated using Fricke dosimetry and compared with three ionization chambers (NE2571, NACP02, ROOS). The combined uncertainties in the experimental fCo(E) factors determined in this work are less than about 0.4% (1 SD), which is appreciably smaller than the uncertainties up to 1.4% (1 SD) reported for other calculated values in the literature. Concerning the Varian 2300C/D beams, the measured fCo(E) values decrease from 1.065 to 1.049 +/- 0.004 (1 SD) when the energy at depth in water increases from 2.6 to 14.1 MeV; the agreement with Monte Carlo calculations is better than 0.5%. For the Racetrack MM50 pulsed-scanned beams, the average experimental value of fCo(E) is 1.071 +/- 0.005 (1 SD) for a mean electron energy at depth Ez ranging from 4.3 to 36.3 MeV: fCo(E) is up to 2% higher for the MM50 beams than for the 2300C/D beams in the range of the tested energies. The energy correction factor for LiF powder (3 mm diameter and 15 mm length) varies with beam quality and type (pulsed or pulsed-scanning), cavity size and nature of the surrounding medium. The fCo(E) values obtained for the LiF powder (3 mm diameter and 15 mm length) irradiated in water, have been applied to the EQUAL external audit network, leading to a good agreement between stated and measured doses, with a mean value of 1.002 +/- 0.022 (1 SD), for 170 beam outputs checked (36 electron beam energies) in 13 'reference' radiotherapy centres in Europe. Such fCo(E) data improve the accuracy of the absorbed dose TLD determination in electron beams, justifying their use for quality control in radiotherapy.

A Method of Characteristics Computer Program for Three-Dimensional Supersonic Internal Flows

DTIC Science & Technology

1979-01-01

t s a r e i n good a g r e e m e n t w i t h t h e r e s u l t s f r o m a w e l l - e s t a b l i s h e d c o m p u t e r p r o g r a m...of the Lockheed axlsymmetrlc MOC computer program (Ref. 6) which Is well verified and widely used. The results from the two programs are in good ...F ( INE IGHoEOe 2) RETURN 99 CON’f |NUE VlR[ TE( 61 7) STOP END CALL RNEXG CALL REAONE 54 AEDC-TR-78-68 21 SUSROUTI NE NEIGH

The ionic track in the F1-ATPase from the thermophilic Bacillus PS3.

PubMed

Bandyopadhyay, Sanjay; Allison, William S

2004-03-09

Only beta-beta cross-links form when the alpha(3)(betaE(395)C)(3)gammaK(36)C (MF(1) residue numbers) double mutant subcomplex of TF(1), the F(1)-ATPase from the thermophilic Bacillus PS3, is slowly inactivated with CuCl(2) in the presence or absence of MgATP. The same slow rate of inactivation and extent of beta-beta cross-linking occur upon treatment of the alpha(3)(betaE(395)C)(3)gamma single mutant subcomplex with CuCl(2) under the same conditions. In contrast, the alpha(3)(betaE(395)C)(3)gammaR(33)C and alpha(3)(betaE(395)C)(3)gammaR(75)C double mutant subcomplexes of TF(1) are rapidly inactivated by CuCl(2) under the same conditions that is accompanied by complete beta-gamma cross-linking. The ATPase activity of each mutant enzyme containing the betaE(395)C substitution is stimulated to a much greater extent by the nonionic detergent lauryldimethylamine oxide (LDAO) than wild-type enzyme, whereas the ATPase activities of the gammaR(33)C, gammaK(36)C, and gammaR(75)C single mutants are stimulated to about the same extent as wild-type enzyme by LDAO. This indicates that the E(395)C substitution in the (394)DELSEED(400) segment of beta subunits increases propensity of the enzyme to entrap inhibitory MgADP in a catalytic site during turnover. These results are discussed in perspective with (i) the ionic track predicted from molecular dynamics simulations to operate during energy-driven ATP synthesis by MF(1), the F(1)-ATPase from bovine heart mitochondria [Ma, J., Flynn, T. C., Cui, Q., Leslie, A. G. W., Walker, J. E., and Karplus, M. (2002) Structure 10, 921-931]; and (ii) the possibility that the betaE(395)C substitution might induce a global effect that alters affinity of noncatalytic sites for nucleotides or alters communication between noncatalytic sites and catalytic sites during ATP hydrolysis.

Integration of the Trivariate Normal Distribution Over an Offset Sphere and an Inverse Problem

DTIC Science & Technology

1988-02-01

i.e., S ; (x - H)2 + (y - K)2 + (z - L)2 - R2 • (3) The kill probability P is then given by fL+R .K+Y CH +X P= JL-RJK+Y fHXF(x,y,z,u,v,w) dx dy dz, (4...7838 IF A*E9*E9>3.28E-3 THEN 8855 7835 C=.5-Y+.5 7848 W=(.5-SQR(Y)*(.5+(.5-Y/3))/Spi )’C 7845 U=1’A 7858 Z=SQR(Z+Z) 7855 IF Lə THEN Z=-Z 7868 IF I>=2

The Relativistic Solar Proton Event of 11 June 1991

DTIC Science & Technology

1993-01-01

A D-A 78 6 2 ATON ~ t ~e~~orForm Approved ""MB No 0, ,0188 u~ii..iuuum ii~uu u~i o zj r~1 cmments rojaraing’ -ts ouc~er *ýtjm.,te )-, ther 3ýo’ ) s...8217L1G..4f~i ,,4eC~ j . rt ’Cr ntorr-jriop6#norr jE tr~ 4Orq , ?left~f ,n IIIIIIIIIIII| |I I II ~~e-Gr .... ýC •O . ....... Ŕ .... %8...Apatity, Russia and Mawson , Antarctica recorded an - 7 percent increase while stations viewing in the probable "reverse" direction such as Tixie Bay

Enhanced vector borne disease surveillance of California Culex mosquito populations reveals spatial and species-specific barriers of infection.

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanderNoot, Victoria A.; Curtis, Deanna Joy; Koh, Chung-Yan

Monitor i ng in f ectio n s in v ect o rs su c h as m osquit o es, s a nd fl i es, tsetse fl i es, a nd ticks to i denti f y hu m a n path o gens m a y s e r v e as a n ear l y w arn i ng det e ction system t o dir e ct loc a l g o v er n ment dise a se pr e v en t i v e m easu r e s . Onemore » major hurdle i n de t ection is the abi l i t y to scre e n l arge n u mbers of v e c t ors for h uman patho g ens w i thout t h e u s e of ge n o t y pe - s p ecific m o lecu l ar tec h nique s . N e x t genera t ion s equ e nc i ng (NG S ) pr o v i des a n unbi a sed p latfo r m capab l e of identi f y i ng k n o w n a n d unk n o w n p ath o ge n s circula t ing w i thin a v e ctor p opul a tion, but utili z ing t h is te c h nolo g y i s tim e - con s u ming a n d cos t l y for v ecto r -b o rne disease su r v e illan c e pr o gra m s. T o addr e s s this w e d e v e lop e d cos t -eff e ct i v e Ilumina(r) R NA- S eq l i bra r y p r epara t ion m e thodol o gies i n con j u n ction w i t h an automa t ed c ompu t at i onal a n a l y sis pipel i n e to ch a racter i ze t h e microbial popula t ions c ircula t i n g in Cu l e x m o squit o e s (Cul e x qui n quef a s c iatu s , C ul e x quinq u efasc i atus / pip i ens co m pl e x h y bri d s, and C u l e x ta r salis ) t hroug h out Californ i a. W e assembled 2 0 n o vel a n d w e l l -do c ume n ted a r b o v i ruses repres e nting mem b e rs of B u n y a v ir i da e , F l a v i virid a e, If a virida e , Meson i v i rida e , Nid o v iri d ae, O rtho m y x o virid a e, Pa r v o v iri d ae, Re o virid a e, R h a b d o v i rid a e, T y m o v iri d ae, a s w ell as s e v e r al u n assi g n e d v irus e s . In addit i o n, w e m app e d mRNA s pecies to d i vergent s peci e s of t r y panos o ma a nd pl a s modium eu k a r yotic parasit e s and cha r a c terized t he p r oka r yot i c microb i al c o mposit i on to i d enti f y bacteri a l tran s c r ipts der i v ed from wolba c hia, clo s tridi u m, m y c oplas m a, fusoba c terium and c am p y l o bacter bac t er i al spec i e s . W e utilized the s e mic r obial transcri p tomes pre s e nt in g e ogra p hical l y defined Cul e x po p ul a tions to defi n e spatial and m osqui t o specie s -spec i fic ba r r iers of i n fecti o n. T he v i r ome and microbi o me c o mpos i tion id e ntified in e ach mosqui t o p o ol pr o v i ded suf f icient resolut i on to dete r m i ne both the mosq u ito species and the g e o graphic regi o n in Californ i a w h e re t h e mosqui t o po o l orig i n ated. T his d a ta pr o v i des ins i ght in t o the compl e x i t y of microb i al spec i es cir c ulati n g in med i cal l y i mport a nt Culex mosqui t oes a nd t h eir potent i al im p act o n t he tran s missi o n of v ector-b o rne human / veter i na r y p a t hogens in C a liforn i a.« less

Molecular Dynamics Simulations of Hugoniot Relations for Poly[methyl methacrylate

DTIC Science & Technology

2011-11-01

A Method for Atomistic Simulations of Shocked Materials. Physical Review E 2000, 63, 016121. 5. Plimpton , S . Fast Parallel Algorithms for Short...5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Tanya L. Chantawansri, Edward F. C. Byrd, Betsy M. Rice, and Jan W. Andzelm 5d. PROJECT NUMBER 5e. TASK...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: RDRL-WMM-G Aberdeen

Biomechanical and Biochemical Cellular Response Due to Shock Waves

DTIC Science & Technology

2008-12-01

112, 1183-1195. Yen, C.-F., 2008, US Army Reserach Laboratory. Zhong, P., I. Cioanta, F. H. Cocks, and G. M. Preminger, 1997: Inertial cavitation...2940-2950. Zhong, P., H. F. Lin, X. F. Xi, S. L. Zhu, and E. S. Bhogte, 1999: Shock wave-inertial microbubble interaction: Methodology

Archeological Excavations at Two Prehistoric Campsites Near Keystone Dam, El Paso, Texas.

DTIC Science & Technology

1985-07-19

LA Cl) en n en eneM 260 E-a~ 4) V I-II 1-44- 060 0 C.L 0 0. 0. U . 0 0 c 4-. 4-1 b ) 4- 0 0)b Z- c. Vd c*1. ) 1- . - -c*1 -* -4 *d d-,I -bo~ -I . as4...2 17n33w 4 1 2311 flk 3 17n33w 0 2 2017 f1k 2 17n33w 5 5 2326 fUk 3 10sl4w 5 2 2017 f1k 3 17n33w 5 4 2328 fUk 2 10sl4w 7 2 2018 flk 3 17n33w 6 1

30 CFR 943.15 - Approval of Texas regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), (f), .195(a); 785.200(a), (b), (c), (f) through (i); 786.216(p); 788.230(a)(4), (5), (6); 788.232(c...), (4), (b); .129, (a), (b), (1), (3); 780.141(g), (h); .142(b)(11), (c), (d), .146 (a) through (e...; 12.77; 12.111(1)(H); 12.112(b)(4); 12.113(a); 12.118(a) and (c); 12.151(a)(2); 12.158(a) and (c); 12...

The Comanche and the Albatross: About Our Neck Was Hung

DTIC Science & Technology

2014-06-01

aircraft .22 F-35 research, development, test, and evaluation funds are left intact for systems migration and maintenance of the aircraft already...and EPAWSS. c The F-15G (called EF-15E by Boeing) moves the EW systems from the EA-18G to the F-15E+. d New-build aircraft were priced for both...fighter fleet with the F-35A. This stealthy aircraft pos-sessed advanced technology and was no more expensive than the aircraft it was designed to

Study of Helicopter Roll Control Effectiveness Criteria.

DTIC Science & Technology

1986-04-01

a EE-E~Cd -P1 P1P1 1CP m0 cd 2 c. .4 .0 . l 0- P1 1. -P 4-NC4 aV .4 0 0 0 0 .’C d d0 df ’Sasg.- oala 8isaaaa 000000 4 Ip~ ~ W, . . 1 o5i 0~ 16a !1...0nemeee erm~ Cal S-!1 4 !1 14 C !V : - ro0 I 0 010 mm a, ma "O acaro . r * za * An PO U n249X rc W ti C! e4! 19 40: t rIet m1! C4 F. 2 ~ee i mIon f I e...Copability 20 - -80 -60 -40 -20 20 40 60 80 BANK ANGLE CHANGE, Ave (dog) IID. Sw -40 -60 HUD Tracking Pilot Wilson Configuration I -80 - Run B83

National Dam Inspection Program. Perrins Marsh Dam (NDI I.D. PA-0886, DER I.D. 066-005), Susquehanna River Basin Whitelock Creek, Wyoming County, Pennsylvania. Phase I Inspection Report,

DTIC Science & Technology

1981-01-01

4c sw- 0mr- w <L -- 0 I- 0. .1 I0 W ’- -o’ -3 w XLW 8 0 WW 4CFO .-. .- -4 >(lJ K 0 E-#F-0 c...2 -. 4-; In cnz KW cc 8 0 0 I f4 (z~ 0- 0- 0- -- .10 ’ 4c 0z J It’ 00 it w .C 0 W 040 ~񕋘 LL. i ao0000 11.4 Or. z ZOO 3- LCW J- zw a J Cz 4 WW L...a* o darDf Ma r, in ori~e s.Vsaa rsnre (’,. mi ,-te ~ b . C, ."s ...... .- - - - ln,V,,i:e, .’ ,. . "(’ hrm ,..,o lrda hind ’ ,++r!l, hert.

Negative Declaration of Environmental Effects of Leith Creek Scotland County, North Carolina, Flood Control Project.

DTIC Science & Technology

1977-01-01

area is limited to that 1.97 mile portion of Leith Creek between Gill Street and the L & S Railroad just above State Road . 1645 ( Fertilizer Plant...yj0 U.L e QC e kt V C S L-Co L. U’L -Lb’L r C, CL :, IUI -j.’ y( auo intcet -Ui p o v Id ia q ’:F cc~ Lc s ;It uet ’c C 4 a ’iC 0 dis"tLssed the Le~f...34 - Sites and Methods of more fill due to the access required than the Disposal proposed action. Pumping of the excavated mate- rial is possible

Vapor-Liquid Equilibrium in the Mixture 1,1-Difluoroethane C2H4F2 + C4H8 2-Methylpropene (EVLM1131, LB5730_E)

NASA Astrophysics Data System (ADS)

Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Vapor-Liquid Equilibrium in the Mixture 1,1-Difluoroethane C2H4F2 + C4H8 2-Methylpropene (EVLM1131, LB5730_E)' providing data from direct measurement of pressure and mole fraction in vapor phase at variable mole fraction in liquid phase and constant temperature.

Improving Cancer Detection and Dose Efficiency in Dedicated Breast Cancer CT

DTIC Science & Technology

2011-02-01

17. A. E. Burgess, F. L. Jacobson, and P. F. Judy , “ Human observer detection experiments with mammograms and power-law noise,” Med. Phys., Vol. 28...Jacobson F L and Judy P F 2001 Human observer detection experiments with mammograms and power-law noise Med. Phys. 28 419–37 Crawford C R and Kak A C 1979...anthropomorphic head phantom was designed for realistically simulating human head [12], it features not only a natural human skeleton but also contrast

77 FR 74472 - Application to Export Electric Energy; Energia Renovable S.C., LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

... Renovable S.C., LLC AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Energia Renovable S.C., LLC (Energia Renovable) has applied for authority to transmit....C. 7151(b), 7172(f)) and require authorization under section 202(e) of the FPA (16 U.S.C.824a(e...

United States Air Force Statistical Digest, Fiscal Year 1961. Sixteenth Edition

DTIC Science & Technology

1961-09-30

E __ _ SUBJECT: Public Release Approval Request I...for 1945-2005 (Please include page count) A UTHORIORGANIZA TION: ____ ----"""SA’-"F’-’-~""M"-’-"C~ E __ _ PRESENTATION TO: General Public DATE: As...34"C t=€~dC( 16 (Print Reviewer’S Name/duty title/phone numbyr) ;::" - e -. (fv ~ 1\\ :;’" e c ŕ-0 I"’ rt ~ D5 I\\P/I-+O (:c, 17 -5 GOO .J REPl:Y

Applicability of SREM to the Verification of Management Information System Software Requirements. Volume II.

DTIC Science & Technology

1981-04-30

f --tlu Final-Report: Applicability of SREM to the Verification of Management Information System Software Requirements, wtch was prepared for the Army...MA _________ TO ________ UTA 1ASE ___________ StMZ25. 70.aC. .. 3CA, c(ie m(Sl f :~ rin I : ruq in SBII Z tSI. M 4.7/.3 69.9 . MA S U/WA0 1.241.5 96.8...IR.D iTEM B-2 C4 .4 . I.I z- 0 44 f - U l c- I ao V. a, I. vv!N0 ~ q * a - i= - a ~ ePcu m ~ bft 0 = z z z z z Uz 4 P4 -F5 zz - -4 zzz z C6 z c. 0. 4 4 v

Novel Compounds from Shark and Stingray Epidermal Mucus With Antimicrobial Activity Against Wound Infection Pathogens

DTIC Science & Technology

2013-03-01

530-E6 MSSA, MRSA, E. coli, VRE, E. faecalis, B. subtilis 530-E7 MSSA, MRSA, E. coli, VRE, E. faecalis, B. subtilis B. anthracis, Micrococcus sp...530-E10 MSSA, MRSA, E. coli, VRE, E. faecalis, B. subtilis Micrococcus sp. 530-A5 VRE 530-B12 VRE 530-C12 VRE B. anthracis 530-D12 VRE 530-E12...VRE Micrococcus sp. 530-F11 VRE Micrococcus sp. 530-F12 VRE Enterococcus. faecium Figure 9. Pathogen overlay assay plates showing

U.S. EPA, Pesticide Product Label, RANGE CATTLE LIVESTOCK & SHEEP DIP CONCENTRATE, 03/02/1984

EPA Pesticide Factsheets

2011-04-21

... CiSDc~e of in a ~an,tdr.f ~arCf1:1 )r lnc~'1erd~~cn, crt 1~ d~~owe~:'/ sta~e ~nc :oca1 aLJt~ori~ies. ~~ :urp~~c. :; Jur··~~, s:a, :~~ ~f ;~~~e. ...

Word Criticality Analysis. MOS: 05C. Skill Levels 1 & 2.

DTIC Science & Technology

1981-09-01

selected by subject matter/job experts knowledgeable in their NOS. The vocabulary set used as the basis for critical word analysis was the Vord...reports completed last (i.e., dated Jan-Mar 82). 3. Word Criticality Index: The following 5 point rating scale was used by a team of up to 3 subject...r- V, w-. U =* IV - .0~~~~~9 IN’ N .1 0 0f 4rlfC f U’.*.ffi" 9.~ ~ ’ r. L . VN 0, m 4’ f’l M 0 (.f, rnV 0.i3 C.. ~,’ efl CG if r 0.9-p C an SIN W’i I

The Mechanism of Action of Unique Small Molecules that Inhibit the Pim Protein Kinase Blocking Prostate Cancer Cell Growth

DTIC Science & Technology

2010-05-01

shown. (E) Cap-dependent ( gray bars) and IRES-dependent (black bars) translation in MEFs as measured by Renilla and Firefly luciferase activities...AGC ATC AAC C; EPHA2-R, GTG ACC TCG TAC TTC CAC ACT C. HER3-F, CGA TGC TGA GAA CCA ATA CCA G; HER3-R, ATA GCC TGT CAC TTC TCG AAT C. INSR-F, GGA AGT...TAC GTC TGA TTC GAG G; INSR-R, TGA GTG ATG GTG AGG TTG TG. IGF1R-F, CCT GCA CAA CTC CAT CTT CGT G; IGF1R-R, CGG TGA TGT TGT AGG TGT CTG C. EGFR-F

RAF Woodbridge, UK. Revised Uniform Summary of Surface Weather Observations. Parts A-F.

DTIC Science & Technology

1988-02-01

LOPFILt I ?CKS AL L AVAI L A L c i tiATI(NS 6 "LK~ ISCL UC tS -’ CUPLY OO-rVATT! n Ns lP AP C %’ P 4r L(CEL) IIN LOLIIMSS E(-7 3, 1.4 F LLMS I / I... P "A121 N S Aw 51,0 TO 595b IR 012,1 91v S I ( . .0C . .c 3.2 3. 7. 1 3. . 3 03-G5 I .: e9.9 95. ’.0 .3 !5 06OA-0. 3 7.4 4. 33. I 2ŕ.. 19. z3 09-11...Pt:C 4 -: ION1h: S57 I fAIN FRINU SNO. A Of MOOL I % ,) HOURS IT4S LO p kAI N O HAIL !ITH ft LIAR LU. iNu 7iC A’ItH03 57:10: (LST I u’I ZLL L UI SLEET

Novel Preclinical Testing Strategies for Treatment of Metastatic Pheochromocytoma

DTIC Science & Technology

2015-11-01

Girma M. Woldemichael b, Carole Sourbier c, Martin J. Lizak d, James F. Powers e, Arthur S. Tischler e, Karel Pacak a a Program in Reproductive... Petra Bullova, Svenja Nölting, Hana Turkova, James F. Powers, Qingsong Liu, Sylvie Guichard, Arthur S. Tischler, Ashley B. Grossman, and Karel Pacak

Statistical Reproducibility of the Dynamic and Static Fatigue Experiments.

DTIC Science & Technology

1980-10-01

82171a no 3 a s d e te rm-,I n ed7 from t Ynamic ’ra-,4-e 2x oe r imen. Figure 2. T-he c oeffic 4e nt o - v arari an ( C . o f .4eib L’ sIatce --ar a-:e...e rc lecnnique to aeterr-ine zne v~iidit of the assumptions. - .2 Static Fatioue Static -aticue tests entai- , the reDeatec measuremen- c - azure ...ress -ance ncreased, anc- tec.-ease: zs n :El ~ c a -amet: -7 4creas2c. -o r a ze sac, nC~e 3Es3 ra-.<e ~ D 3 s ar, c a s n amD-e , s e : ) rrc uCb c 0

Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary.

PubMed

Puangsombat, Kanithaporn; Smith, J Scott

2010-03-01

Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature. Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side. Five rosemary extracts extracted with different solvents were used in this study: extract 100W (100% water), 10E (10% ethanol), 20E (20% ethanol), 30E (30% ethanol), and 40E (40% ethanol). The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified. All of the patties contained 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts. All rosemary extracts significantly decreased the levels of MeIQx and PhIP at both cooking conditions. When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation. Rosemary extract 20E showed the greatest inhibition of MeIQx (up to 91.7%) and PhIP (up to 85.3%). The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay. Rosemary extract 10E and 20E contain a mixture of rosmarinic acid, carnosol, and carnosic acid. It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.

[Electrogastrography and gastric emptying in non organic dyspepsia].

PubMed

López Gastón, A R; López De Luise, G A; Sarmiento, A

1996-01-01

Electrogastrography allows to determinate the dominant frequency of gastric E.C.A. (electrical control activity). The aim was to investigate the gastric E.C.A. in a population of patients suffering from non-organic dispepsia (N.O.D.). Eighteen controls (9 males, 9 females, mean age 46.4 years old, SEM 3.72, range 24-72) and 52 dyspeptic patients (18 males, 34 females, mean age 54.19 years old, SEM 2.38, range 17-86) were studied. Two skin surface electrodes Ag-2ClAg were placed on epigastric area following a probabilistic antral axe. Reference electrode was placed on the right quadrant skin. In 5 patients, recordings with needle and cutaneous electrode were compared. Analogic waves were filtered, digitalized and processed. Signals were analyzed using F.F.T. (Fast Fourier Transformated) Only the predominant frequency in each block was considered, and percentage of total abnormalities on total recording time lesser than 2 c.p.m. or more than 4 c.p.m. was accepted. Recording were taken in fast time during 30 minutes, and 30 minutes after a meal containing 230 Cal. Running spectral analysis with F.F.T. In 43 non-selected patients the gastric emptying time of a mixed meal marked with 99 Tc in the solid phase was studied. 60.45% showed delayed gastric emptying. Mean of fast E.C.A. was 2.99 c.p.m. in controls, Vs 3.34 c.p.m. in dispeptic patients (p > 0.001). In the post-prandial period, mean of E.C.A. was 3.53 c.p.m. in N.O.D., and these differences were not significatives ("t", NS). 22% of controls showed isolated periods of tachygastria, but never more than 8% of the total recording time. It was seen seven six and forty five percent of arrhythmias were observed (71.15% tachygastria, 4.76% bradygastria, and 19.23% mixed) during post prandial recording in N.O.D. 48% of tachygastrias were between the range 30-60% of the time recording. Ninety six and one percent of patients with abnormal gastric emptying had gastric arrhythmias (0.05 > p > 0.02) Vs 50% in patients with normal gastric emptying. Needle recording increased about 200-300% the signal power. It would be the better choice in cases of hairy abdominal skin. a) More than 76% of patients with N.O.D. had abnormal recording of E.C.A. beyond these observed in controls; b) tachygastria was the more frequent abnormality observed; c) the more severe clinical cases were associated with bradygastria; d) No association between symptoms and abnormal gastric emptying was found; e) E.G.G. abnormalities were seen in 96% of patients with abnormal gastric emptying, Vs 50% in normal gastric emptying; f) Needle electrodes let a better recording of E.G.G. signal; g) No association was found between abnormalities in gastric emptying and/or E.G.G., and clinical subtypes of Dyspepsia.

Two new γ chain variants: Hb F-Augusta GA [(G)γ59(E3)Lys → Arg; HBG2: c.179A > G] and Hb F-Port Royal-II [(A)γ125(H3)Glu → Ala; HBG1: c.377A > C].

PubMed

Kutlar, Ferdane; Ameri, Afshin; Patel, Niren H; Zhuang, Lina; Johnson, Lee E; Cheng, Michael L; Kutlar, Abdullah

2014-01-01

The total number of hemoglobin (Hb) variants so far reported to the HbVar database is 1598 (April 9 2014) and 130 of them are fetal Hb variants. Fetal Hb are categorized as two different subunits, (G)γ- and (A)γ-globin chains, and γ chain variants can be observed in both subunits. There are 72 (G)γ- and 58 (A)γ-globin chain variants. Most of them are clinically silent and detected during newborn screening programs in the USA and outside the USA. In this report, we discuss the molecular characteristics and diagnostic difficulties of two new γ-globin chain variants found in an African American baby with no clinical symptoms. One is a new (G)γ-globin chain variant, Hb F-Augusta GA [(G)γ59(E3)Lys → Arg; HBG2: c.179A > G] and the other one is Hb F-Port Royal-II [(A)γ125(H3)Glu → Ala; HBG1: c.377A > C].

20. 'Erection Plan, Renewal of Bridge 210 C over Sacramento ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. 'Erection Plan, Renewal of Bridge 210 C over Sacramento River near Tehama, Calif., 3 140'-0' S. T. Riveted Thru Truss Spans, 17'-9' C. to C. Trusses, 31'-0' C. To C. Chords. U.S.S. P. Co. Pacific Coast Dept., Order No. SF 604, Southern Pacific Co., Order No. 51168-P-38428, 1925 Specifications, Scale in. ft., American Bridge Co., Ambridge Plant, Dwgs. made at Ambridge No. 5 in charge of Reehl, Detailed by W.F.R., Date, Checked by L.A.E., Date 1/5/29, Fld. conn. chk. by ENN, Date 3/9/29, Order No. F5659, Sheet No. E3.' - Southern Pacific Railroad Shasta Route, Bridge No. 210.52, Milepost 210.52, Tehama, Tehama County, CA

Velocity of Ejection of Meteor Particle from the Nucleus of Comets

NASA Astrophysics Data System (ADS)

Safarov, Abduljalol; Ibadinov, Khursand

2016-07-01

The time and velocity of dust particles of anomalous tail of comets was determine. Velocity ejection of dust particles from the nuclei of comets C/1851 U1, C/1877 G1, C/1921 E1, C/1925 V1, C/1962 C1, C/1969 T1, C/1975 V2, 2P/1924 and 26P/1927 F1 reaching up to 0.4 km/s can be attributed to the removal of large dust particles from the surface of the icy nucleus of comet sublimating molecules. In comets C/1823 Y1, C/1844 Y1, C/1882 R1, C/1883 D1, C/1888 R1, C/1892 E1, D/1894 F1, C/1910 A1, C/1921 E1, C/1922 U1, C/1930 D1, C/1930 O1, C/1931 P1, C/1932 M1, C/1935 A1, C/1954 O1, C/1961 O1, C/1963 A1, C/1968 H1, C/1973 E1, C/1980 P1, C/1984 N2, C/1987 P1, C/1995 O1, C/1999 H1, C/1999 T2, C/1999 S4, C/2002 T7, C/2004 F4, C/2004 Q2, 6P/1950, 7P/1869 G1, 7P/1933, 10P/1930, 19P/1918, 34P/1938 J1, 35P/1939, 67P/1982, 73P/1930 J1, 96P/1986 J1 and 109P/1862 O1 ejection velocity (up to a few km/s) of the particles of anomalous tail from the nuclei significantly exceed the thermal velocity of the molecules sublimating ice nuclei. Such velocity may be explained by the removal of particles from the surface of the nucleus after the collision of the comet nucleus with meteoroids

JAL (RH48) blood group antigen: serologic observations

PubMed Central

Lomas-Francis, Christine; Alcantara, Denden; Westhoff, Connie; Uehlinger, Joan; Valvasori, Marilia; Castilho, Lillian; Reid, Marion E.

2009-01-01

BACKGROUND JAL (RH48) is a low-prevalence antigen in the Rh blood group system and anti-JAL has caused hemolytic disease of the newborn. JAL is associated with either a haplotype carrying depressed C and e antigens or one carrying depressed c and e antigens. Blood samples from JAL+ people were tested, published serologic findings were confirmed, serologic studies were extended to include expression of other Rh antigens, and the antibody specificities produced by three sensitized JAL+ probands are reported. STUDY DESIGN AND METHODS Red blood cell (RBC) samples from 17 (12 probands) JAL+ persons were tested by hemagglutination using standard methods. RESULTS RBCs from both the Caucasian JAL+ probands had the (C)(e) haplotype and weakened C, e, hrB, and hrS antigens. JAL+ samples from black persons had the (c)(e) haplotype and expressed weakened c, e, f, V, VS, hrB, and hrS antigens. Plasma from three sensitized c+e+ JAL+ probands contained alloanti-c, alloanti-e, or alloantibody of apparent anti-Rh17 specificity. This study shows that this alloanti-Rh17–like antibody recognizes the high-prevalence antigen antithetical to JAL that has been named CEST. CONCLUSIONS The presence of the JAL antigen has a quantitative (weakening) effect on the expression of C, e, hrB, and hrS antigens in Caucasian persons and of c, e, f, V, VS, hrB, and hrS antigens in people of black African ancestry. A qualitative effect also was demonstrated by the presence of alloanti-c or alloanti-e in the plasma of two transfused c+e+ patients and by an antibody (anti-CEST) that recognizes the high-prevalence antigen antithetical to JAL. PMID:19192256

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gendron, Frederic; Fleischauer, Valerie R.; Duignan, Thomas J.

Here, we present a combined ab initio theoretical and experimental study of the magnetic circular dichroism (MCD) spectrum of the octahedral UCl 6- complex ion in the UV-Vis spectral region. The ground state is an orbitally non-degenerate doublet E 5/2u and the MCD is a $C$-term spectrum caused by spin–orbit coupling. Calculations of the electronic spectrum at various levels of theory indicate that differential dynamic electron correlation has a strong influence on the energies of the dipole-allowed transitions and the envelope of the MCD spectrum. The experimentally observed bands are assigned to dipole-allowed ligand-to-metal charge transfer into the 5f shell,more » and 5f to 6d transitions. Charge transfer excitations into the U 6d shell appear at much higher energies. The MCD-allowed transitions can be assigned via their signs of the $C$-terms: Under O h double group symmetry, E 5/2u → E 5/2g transitions have negative $C$-terms whereas E 5/2u → F 3/2g transitions have positive $C$-terms if the ground state g-factor is negative, as it is the case for UCl 6-.« less

Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated allergic response in RBL‑2H3 cells.

PubMed

Yoo, Jae-Myung; Yang, Ju Hye; Yang, Hye Jin; Cho, Won-Kyung; Ma, Jin Yeul

2016-02-01

Arctium lappa fruit has been used in traditional medicine, and it is known to exert beneficial effects, such as antioxidant, anti-inflammatory and anticancer effects. However, the effects of the Arctium lappa fruit on the allergic response remain unknown. In this study, we evaluated the anti-allergic effects of Arctium lappa fruit extract (AFE) and its fermented form (F-AFE) using immunoglobulin E (IgE)-activated RBL‑2H3 cells. To investigate the anti-allergic effects of AFE or F-AFE, we examined the release of β-hexosaminidase, a key biomarker of degranulation during an allergic reaction, and the production of pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) in the cells treated with or without the above-mentioned extracts. AFE weakly inhibited the release of β-hexosaminidase, whereas F-AFE significantly suppressed the release of β-hexosaminidase in a dose-dependent manner. Consistently, F-AFE suppressed the production of TNF-α and PGE2 in a dose-dependent manner. F-AFE exerted an inhibitory effect on the production of β-hexosaminidase, TNF-α and PGE2 with an IC50 value of 30.73, 46.96 and 36.27 µg/ml, respectively. Furthermore, F-AFE inhibited the phosphorylation of Lyn, Fyn and Syk, which are involved in the FcεRI signaling pathway, that of phosphoinositide phospholipase C (PLC)γ1/2 and protein kinase C (PKC)δ, which are associated with the degranulation process, as well as that of extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase 1/2 (JNK), p38 and Akt, which are associated with cytokine expression. In the late phase, F-AFE partially suppressed the phosphorylation of cytosolic phospholipase A2 (cPLA2), but not the expression of cyclooxygenase (COX)-2. To compare and identify the major components of the two extracts, we used high-performance liquid chromatography. The levels of arctigenin, one of the major compounds, were elevated 6-fold in F-AFE compared with AFE, whereas the levels of arctiin, an arctigenin glycoside, were decreased in F-AFE by approximately 57.40%. These results suggest that arctigenin plays an important role in the anti-allergic effects of F-AFE. Taken together, F-AFE containing anti-allergic phytochemicals, including arctigenin, inhibited the activation of the FcεRI receptor induced by the antigen‑IgE complex. Such effects may provide further information for the development of a phytomedicine for allergic diseases.

Molecular analysis of the genes involved in the biosynthesis of serotype specific polysaccharide in the novel serotype k strains of Streptococcus mutans.

PubMed

Nomura, R; Nakano, K; Ooshima, T

2005-10-01

We previously reported the new serotype k of Streptococcus mutans, which, compared to serotypes c, e, and f, features a drastic reduction in the length of the glucose side chain linked to the rhamnose backbone of the serotype specific polysaccharide. The 5' region of the rgpF gene of serotype k strains contains a distinctive nucleotide sequence, which suggests that an alteration of the rgpF gene in serotype k strains may explain the shortened glucose side chain. However, in the present study, expression of the rgpF gene of MT8148 (serotype c) in serotype k isolates was not found to lead to serotype conversion. Furthermore, mRNA expression of rgpE, known to be associated with glucose side chain formation, was not detected in any of the tested serotype k isolates with an RT-PCR method. The nucleotide alignment of all genes known to be involved in the biosynthesis of serotype specific polysaccharide in serotype k strains was shown to be quite similar to that of serotype c strains, as compared to serotype e and f strains, especially in the region downstream of rgpF. Our results indicate that the common characteristics of serotype k isolates may be caused by a lack of expression of the gene involved in glucose side chain formation.

The Primacy of Depth in Visual Perception.

DTIC Science & Technology

1981-11-01

formulated an 4 - 1I hvothesis known as the "Adjacency principle ", which asserts, in effect. that the interaction among objects in visual snace is an inverse...f e r e f f e c o t u r s Le h r r t u e d 21 N= 5 SUBJECTS INDUCTION DISPARITY = 50 MIN Ŕ-1 STANDARD ERROR1.0- z 0. 9 - 0 o-8 Ld 0.7- LL_ z 0.6- 0 0...DISTRIBUTION LIST OS Department of the Navy CDR Paul R. Chatelier Physiology & Neuro Biology Program Office of the Deputy Under Secretary Code 441B of

Air Cushion Equipment Transporter (ACET) Testing. Volume 2.

DTIC Science & Technology

1986-10-01

m: lllllhllllEEE 1.0. 1-2-5 w lw w w w w -- * e %. f~n4% AD-A188 369 AFWAL-TR-86-3088 VOLUME 11 AIR CUSHION EQ~UIPuMNT TRNSPO’jRTERi (ACET) TESTING T.D... E . COLCLOUGH, J Chief Vehicle E eupment Division .. If your address has changed, if you wish to be removed from our mailing list, or if the addressee...and ZIP CodeI 10. SOURCE OF FUNDING NOS. PROGRAM PROJECT TASK WORK UNIT ELEMENT NO. NO NO NO II TITLE (includ. Securito C f e ,,n 62201F 2402 01 34 12

A review of variant hemoglobins interfering with hemoglobin A1c measurement.

PubMed

Little, Randie R; Roberts, William L

2009-05-01

Hemoglobin A1c (HbA1c) is used routinely to monitor long-term glycemic control in people with diabetes mellitus, as HbA1c is related directly to risks for diabetic complications. The accuracy of HbA1c methods can be affected adversely by the presence of hemoglobin (Hb) variants or elevated levels of fetal hemoglobin (HbF). The effect of each variant or elevated HbF must be examined with each specific method. The most common Hb variants worldwide are HbS, HbE, HbC, and HbD. All of these Hb variants have single amino acid substitutions in the Hb beta chain. HbF is the major hemoglobin during intrauterine life; by the end of the first year, HbF falls to values close to adult levels of approximately 1%. However, elevated HbF levels can occur in certain pathologic conditions or with hereditary persistence of fetal hemoglobin. In a series of publications over the past several years, the effects of these four most common Hb variants and elevated HbF have been described. There are clinically significant interferences with some methods for each of these variants. A summary is given showing which methods are affected by the presence of the heterozygous variants S, E, C, and D and elevated HbF. Methods are divided by type (immunoassay, ion-exchange high-performance liquid chromatography, boronate affinity, other) with an indication of whether the result is artificially increased or decreased by the presence of a Hb variant. Laboratorians should be aware of the limitations of their method with respect to these interferences. 2009 Diabetes Technology Society.

Comprehensive Review of the Future Role of the Reserve Component. Volume 1. Executive Summary and Main Report

DTIC Science & Technology

2011-04-05

C t r Source Integrated Security Posture Defense Planning Scenario April 2008 28 Using selected DoD planning scenarios8 that cover the...Military Sourcing for DoD Humanitarian Crisis Response D C R Mil t r S r i 1. AC primary source for DoD response 2. Some pre-planned RC required...immediately 3. Most RC follow on CRISIS + 30 DAYS Days N o ti o n a l P e rc e n t o f T o ta l F o rc e President Invokes PRC

Diphoton resonance in F-theory inspired flipped SO(10)

NASA Astrophysics Data System (ADS)

Leontaris, George K.; Shafi, Qaisar

2016-10-01

Motivated by the di-photon excess at 750 GeV reported by the ATLAS and CMS experiments, we present an F-theory inspired flipped SO(10) model embedded in E_6. The low energy spectrum includes the three MSSM chiral families, vector-like colour triplets, several pairs of charged SU(2)_L singlet fields (E^c, bar{E}^c), as well as MSSM singlets, one or more of which could contribute to the di-photon resonance. A total decay width in the multi-GeV range can arise from couplings involving the singlet and MSSM fields.

Higher-dimensional attractors with absolutely continuous invariant probability

NASA Astrophysics Data System (ADS)

Bocker, Carlos; Bortolotti, Ricardo

2018-05-01

Consider a dynamical system given by , where E is a linear expanding map of , C is a linear contracting map of and f is in . We provide sufficient conditions for E that imply the existence of an open set of pairs for which the corresponding dynamic T admits a unique absolutely continuous invariant probability. A geometrical characteristic of transversality between self-intersections of images of is present in the dynamic of the maps in . In addition, we give a condition between E and C under which it is possible to perturb f to obtain a pair in .

Field Demonstration for P-D-680 Solvent Replacement (Part II)

DTIC Science & Technology

1998-05-12

jo \\ Ji o < s NJ £. ° 8? Q- 3* £?. «" «< o Ö- 8" 03 O C O ~ e O 3 re *i re re w8 g 3 2> 8 = er ^ o 3 ^ fS Ni O...34 3 3. 3. n_ £ 2. O 2- e. re Z. 2 3 v! 3 oso,o,<f)( ji «s S?3re-t930.Q3^. «o.03rt3-3c"o=; 1 » < 3 -•■n O -t33^c«^3ga3 re...soWfirtH T^ skd uiEita, ox^fifk^. 4. KrflTjTS, SAFETY 0? ALTERATIVE F-D-S80 SOLVENT Have you, cr did you have knowledge of ethers

The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron.

PubMed

Reiber, Kathrin; Reeves, Emer P; Neville, Claire M; Winkler, Robert; Gebhardt, Peter; Kavanagh, Kevin; Doyle, Sean

2005-07-01

Three non-ribosomal peptide synthetase genes, termed sidD, sidC and sidE, have been identified in Aspergillus fumigatus. Gene expression analysis by RT-PCR confirms that expression of both sidD and C was reduced by up to 90% under iron-replete conditions indicative of a likely role in siderophore biosynthesis. SidE expression was less sensitive to iron levels. In addition, two proteins purified from mycelia grown under iron-limiting conditions corresponded to SidD ( approximately 200 kDa) and SidC (496 kDa) as determined by MALDI ToF peptide mass fingerprinting and MALDI LIFT-ToF/ToF. Siderophore synthetases are unique in bacteria and fungi and represent an attractive target for antimicrobial chemotherapy.

Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency: two pathogenic mutations, V133E and C456F, in Japanese siblings.

PubMed

Song, X Q; Fukao, T; Watanabe, H; Shintaku, H; Hirayama, K; Kassovska-Bratinova, S; Kondo, N; Mitchell, G A

1998-01-01

Succinyl-CoA:3-ketoacid CoA transferase (SCOT; EC 2.8.3.5; locus symbol OXCT) is the key enzyme of ketone body utilization. Hereditary SCOT deficiency (MIM 245050) causes episodes of severe ketoacidosis. We developed a transient expression system for mutant SCOT cDNAs, using immortalized SCOT-deficient fibroblasts. This paper describes and characterizes three missense mutations in two SCOT-deficient siblings from Japan. They are genetic compounds who inherited the mutation C456F (c1367 G-->T) from their mother. Their paternal allele contains two mutations in cis, T58M (c173 C-->T) and V133E (c398T-->A). Expression of SCOT cDNAs containing either V133E or C456F produces no detectable SCOT activity, whereas T58M is functionally neutral. T58M is a rare sequence variant not detected in 100 control Japanese alleles. In fibroblasts from the proband (GS02), in whom immunoblot demonstrated no detectable SCOT peptide, we measured an apparent residual SCOT activity of 20-35%. We hypothesize that the high residual SCOT activity in homogenates may be an artifact caused by use of the substrate, acetoacetyl-CoA by other enzymes. Expression of mutant SCOT cDNAs more accurately reflects the residual activity of SCOT than do currently available assays in cell or tissue homogenates.