Sample records for c11 c12 c44

  1. Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake.

    PubMed

    Sun, Peng; Antoun, Joseph; Lin, Dao-Hong; Yue, Peng; Gotlinger, Katherine H; Capdevila, Jorge; Wang, Wen-Hui

    2012-02-01

    The aim of this study is to test whether the Cyp2c44 epoxygenase-dependent metabolism of arachidonic acid prevents the hypertensive effect of a high K (HK) intake by inhibiting the epithelial sodium channel (ENaC) activity. A HK intake elevated Cyp2c44 mRNA expression and 11,12-epoxyeicosatrienoic acid levels in the cortical collecting duct in Cyp2c44(+/+) mice (wild-type [wt]). However, an HK intake failed to increase 11,12-epoxyeicosatrienoic acid formation in the cortical collecting ducts of Cyp2c44(-/-) mice. Moreover, increasing K intake enhanced arachidonic acid-induced inhibition of ENaC in the wt but not in Cyp2c44(-/-) mice. In contrast, 11,12-epoxyeicosatrienoic acid, a Cyp2c44 metabolite, inhibited ENaC in the wt and Cyp2c44(-/-) mice. The notion that Cyp2c44 is the epoxygenase responsible for mediating the inhibitory effects of arachidonic acid on ENaC is further suggested by the observation that inhibiting Cyp-epoxygenase increased the whole-cell Na currents in principal cells of wt but not in Cyp2c44(-/-) mice. Feeding mice with an HK diet raised the systemic blood pressures of Cyp2c44(-/-) mice but was without an effect on wt mice. Moreover, application of amiloride abolished the HK-induced hypertension in Cyp2c44(-/-) mice. The HK-induced hypertension of Cyp2c44(-/-) mice was accompanied by decreasing 24-hour urinary Na excretion and increasing the plasma Na concentration, and the effects were absent in wt mice. In contrast, disruption of the Cyp2c44 gene did not alter K excretion. We conclude that Cyp2c44 epoxygenase mediates the inhibitory effect of arachidonic acid on ENaC and that Cyp2c44 functions as an HK-inducible antihypertensive enzyme responsible for inhibiting ENaC activity and Na absorption in the aldosterone-sensitive distal nephron.

  2. Room temperature elastic properties of Rh-based alloys studied by surface Brillouin scattering

    NASA Astrophysics Data System (ADS)

    Sumanya, C.; Mathe, B. A.; Comins, J. D.; Every, A. G.; Osawa, M.; Harada, H.

    2014-10-01

    Platinum metal group alloys are promising materials for use in a new generation of gas turbine engines owing to their excellent high-temperature properties. In the present work, room temperature elastic properties of single crystals of Rh3Nb and Rh3Zr are investigated. Surface Brillouin scattering spectra for a range of wave vector directions on the (001) surface have been acquired in order to determine the angular variation of the velocities of the Rayleigh and pseudo-surface acoustic waves and that of the longitudinal lateral wave (LLW) threshold within the Lamb shoulder. The elastic stiffness constants C11, C12, and C44 of these cubic crystal specimens have been derived using two approaches: the first involving the least-squares fit of the combined measured wave velocity data to calculated values and the second an analytical approach using the Rayleigh velocities in the [100] and [110] directions and LLW velocity in the [100] direction, and extracting the elastic stiffness constants from the secular equations for these velocities. Results from the two methods are in good agreement and are for Rh3Nb, C11 = 368 ± 3, C12 = 186 ± 5, and C44 = 161 ± 3 in GPa; and for Rh3Zr, C11 = 329 ± 4, C12 = 185 ± 6, and C44 = 145 ± 4 in GPa.

  3. Generation and performance of special quasirandom structures for studying the elastic properties of random alloys: Application to Al-Ti

    NASA Astrophysics Data System (ADS)

    von Pezold, Johann; Dick, Alexey; Friák, Martin; Neugebauer, Jörg

    2010-03-01

    The performance of special-quasirandom structures (SQSs) for the description of elastic properties of random alloys was evaluated. A set of system-independent 32-atom-fcc SQS spanning the entire concentration range was generated and used to determine C11 , C12 , and C44 of binary random substitutional AlTi alloys. The elastic properties of these alloys could be described using the set of SQS with an accuracy comparable to the accuracy achievable by statistical sampling of the configurational space of 3×3×3 (108 atom, C44 ) and 4×4×4 (256 atom, C11 and C12 ) fcc supercells, irrespective of the impurity concentration. The smaller system size makes the proposed SQS ideal candidates for the ab initio determination of the elastic constants of random substitutional alloys. The set of optimized SQS is provided.

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwarz, R.B.; Bach, H.T.; Harms, U.

    We used a resonant-ultrasound-spectroscopy technique to measure the three independent elastic constants of PdH{sub x}, PdD{sub x}, and PdT{sub x} single crystals at 300 K. For 0.1x0.62 our PdH{sub x} crystals are two-phase mixtures of coherent {alpha} and {beta} hydride phases. For increasing x in this range, C{sub 44} decreases monotonically whereas C'=12(C11-C12) has a concave parabolic dependence. This difference is because C' is softened by an anelastic relaxation resulting from acoustic-stress-induced changes in the shape of the coherent lenticular-shape precipitates ({beta}-hydride precipitates in {alpha}-hydride matrix and {alpha}-hydride precipitates in {beta}-hydride matrix). In the {beta}-phase C' and C{sub 44} decreasemore » with increasing hydrogen (or deuterium or tritium) content. Furthermore, C' exhibits a strong isotope effect whereas C{sub 44} does not. This effect is attributed to differences in the excitation of optical phonons in Pd-H, Pd-D and Pd-T.« less

  5. Gamma rays from the de-excitation of C-12 resonance 15.11 MeV and C-12 resonance 4.44 MeV as probes of energetic particle spectra

    NASA Technical Reports Server (NTRS)

    Crannell, C. J.; Crannell, H.; Ramaty, R.

    1977-01-01

    The flux of 15.11 MeV gamma rays relative to the flux 4.44 MeV gamma rays was calculated from measured cross sections for excitation of the corresponding states of C-12 and from experimental determinations of the branching ratios for direct de-excitation of these states to the ground state. Because of the difference in threshold energies for excitation of these two levels, the relative intensities in the two lines are particularly sensitive to the spectral distribution of energetic particles which excite the corresponding nuclear levels. For both solar and cosmic emission, the observability of the 15.11 MeV line is expected to be enhances by low source-background continuum in this energy range.

  6. Static and vibrational properties of equiatomic Na-based binary alloys

    NASA Astrophysics Data System (ADS)

    Vora, Aditya M.

    2007-09-01

    The computations of the static and vibrational properties of four equiatomic Na-based binary alloys viz. Na0.5Li0.5, Na0.5K0.5, Na0.5Rb0.5 and Na0.5Cs0.5, to second order in local model potential is discussed in terms of real-space sum of Born von Karman central force constants. The local field correlation functions due to Hartree (H), Ichimaru Utsumi (IU) and Sarkar et al. (S) are used to investigate the influence of the screening effects on the aforesaid properties. Results for the lattice constants C11, C12, C44, C12 C44, C12/C44 and bulk modulus B obtained using the H-local field correction function have higher values in comparison with the results obtained for the same properties using IU- and S-local field correction functions. The results for the Shear modulus (C‧), deviation from Cauchy's relation, Poisson's ratio σ, Young modulus Y, propagation velocity of elastic waves, phonon dispersion curves and degree of anisotropy A are highly appreciable for the four equiatomic Na-based binary alloys.

  7. Elastic constants and pressure derivative of elastic constants of Si1-xGex solid solution

    NASA Astrophysics Data System (ADS)

    Jivani, A. R.; Baria, J. K.; Vyas, P. S.; Jani, A. R.

    2013-02-01

    Elastic properties of Si1-xGex solid solution with arbitrary (atomic) concentration (x) are studied using the pseudo-alloy atom model based on the pseudopotential theory and on the higher-order perturbation scheme with the application of our own proposed model potential. We have used local-field correction function proposed by Sarkar et al to study Si-Ge system. The Elastic constants and pressure derivatives of elastic constants of the solid solution is investigated with different concentration x of Ge. It is found in the present study that the calculated numerical values of the aforesaid physical properties of Si-Ge system are function of x. The elastic constants (C11, C12 and C44) decrease linearly with increase in concentration x and pressure derivative of elastic constants (C11, C12 and C44) increase with the concentration x of Ge. This study provides better set of theoretical results for such solid solution for further comparison either with theoretical or experimental results.

  8. Cocrystallization of adamantane-1,3-dicarboxylic acid and 4,4'-bipyridine.

    PubMed

    Pan, Yue; Li, Kunhao; Bi, Wenhua; Li, Jing

    2008-02-01

    The cocrystallization of adamantane-1,3-dicarboxylic acid (adc) and 4,4'-bipyridine (4,4'-bpy) yields a unique 1:1 cocrystal, C(12)H(16)O(4).C(10)H(8)N(2), in the C2/c space group, with half of each molecule in the asymmetric unit. The mid-point of the central C-C bond of the 4,4'-bpy molecule rests on a center of inversion, while the adc molecule straddles a twofold rotation axis that passes through two of the adamantyl C atoms. The constituents of this cocrystal are joined by hydrogen bonds, the stronger of which are O-H...N hydrogen bonds [O...N = 2.6801 (17) A] and the weaker of which are C-H...O hydrogen bonds [C...O = 3.367 (2) A]. Alternate adc and 4,4'-bpy molecules engage in these hydrogen bonds to form zigzag chains. In turn, these chains are linked through pi-pi interactions along the c axis to generate two-dimensional layers. These layers are neatly packed into a stable crystalline three-dimensional form via weak C-H...O hydrogen bonds [C...O = 3.2744 (19) A] and van der Waals attractions.

  9. Piezo-Hall effect and fundamental piezo-Hall coefficients of single crystal n-type 3C-SiC(100) with low carrier concentration

    NASA Astrophysics Data System (ADS)

    Qamar, Afzaal; Dao, Dzung Viet; Dinh, Toan; Iacopi, Alan; Walker, Glenn; Phan, Hoang-Phuong; Hold, Leonie; Dimitrijev, Sima

    2017-04-01

    This article reports the results on the piezo-Hall effect in single crystal n-type 3C-SiC(100) having a low carrier concentration. The effect of the crystallographic orientation on the piezo-Hall effect has been investigated by applying stress to the Hall devices fabricated in different crystallographic directions. Single crystal n-type 3C-SiC(100) and 3C-SiC(111) were grown by low pressure chemical vapor deposition at 1250 °C. Fundamental piezo-Hall coefficients were obtained using the piezo-Hall effect measurements as P11 = (-29 ± 1.3) × 10-11 Pa-1, P12 = (11.06 ± 0.5)× 10-11 Pa-1, and P44 = (-3.4 ± 0.7) × 10-11 Pa-1. It has been observed that the piezo-Hall coefficients of n-type 3C-SiC(100) show a completely different behavior as compared to that of p-type 3C-SiC.

  10. Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis.

    PubMed

    Fang, F; Pan, J; Su, G H; Xu, L X; Li, G; Li, Z H; Zhao, H; Wang, J

    2015-11-30

    Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal-ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Significant associations between ADH1C *1/*2 poly-morphism and pancreatitis risk were observed in both overall meta-analysis for 12 vs 22 (OR = 1.53, 95%CI = 1.12-2.10) and 11 + 12 vs 22 (OR = 1.44, 95%CI = 1.07-1.95), and the chronic alcoholic pancre-atitis subgroup for 12 vs 22 (OR = 1.64, 95%CI = 1.17-2.29) and 11 + 12 vs 22 (OR = 1.53, 95%CI = 1.11-2.11). Significant pancreatitis risk variation was also detected in Caucasians for 11 + 12 vs 22 (OR = 1.45, 95%CI = 1.07-1.98). In conclusion, the ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk, particularly chronic alcoholic pancreatitis risk, with the *1 allele functioning as a risk factor.

  11. Synthesis of [11C]Am80 via Novel Pd(0)-Mediated Rapid [11C]Carbonylation Using Arylboronate and [11C]Carbon Monoxide

    PubMed Central

    2012-01-01

    11C-labeled methylbenzoates [11C]4a–d were synthesized using Pd(0)-mediated rapid cross-coupling reactions employing [11C]carbon monoxide and arylboronic acid neopentyl glycol esters 3a–d under atmospheric pressure in methanol–dimethylformamide (MeOH–DMF), in radiochemical yields of 12 ± 5–26 ± 13% (decay-corrected based on [11C]O). The reaction conditions were highly favorable for the synthesis of [11C]Am80 ([11C]2) and [11C]methyl 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoate ([11C]2-Me) using 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzamide (5), both of which produced a decay-corrected radiochemical yield (RCY) of 26 ± 13%, with >99% radiochemical purity and an average specific radioactivity of 44 GBq/μmol. The yields of [11C]4a, [11C]2-Me, and [11C]2 were improved by the use of a 2-fold excess of the solvents and reagents under the same conditions to give respective yields of 66 ± 8, 65 ± 7, and 48 ± 2%. PMID:24900383

  12. Synthesis of [(11)C]Am80 via Novel Pd(0)-Mediated Rapid [(11)C]Carbonylation Using Arylboronate and [(11)C]Carbon Monoxide.

    PubMed

    Takashima-Hirano, Misato; Ishii, Hideki; Suzuki, Masaaki

    2012-10-11

    (11)C-labeled methylbenzoates [(11)C]4a-d were synthesized using Pd(0)-mediated rapid cross-coupling reactions employing [(11)C]carbon monoxide and arylboronic acid neopentyl glycol esters 3a-d under atmospheric pressure in methanol-dimethylformamide (MeOH-DMF), in radiochemical yields of 12 ± 5-26 ± 13% (decay-corrected based on [(11)C]O). The reaction conditions were highly favorable for the synthesis of [(11)C]Am80 ([(11)C]2) and [(11)C]methyl 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoate ([(11)C]2-Me) using 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzamide (5), both of which produced a decay-corrected radiochemical yield (RCY) of 26 ± 13%, with >99% radiochemical purity and an average specific radioactivity of 44 GBq/μmol. The yields of [(11)C]4a, [(11)C]2-Me, and [(11)C]2 were improved by the use of a 2-fold excess of the solvents and reagents under the same conditions to give respective yields of 66 ± 8, 65 ± 7, and 48 ± 2%.

  13. Elastic Constants of Solids and Fluids with Initial Pressure via a Unified Approach Based on Equations-of-State

    NASA Technical Reports Server (NTRS)

    Cantrell, John H.

    2014-01-01

    The second and third-order Brugger elastic constants are obtained for liquids and ideal gases having an initial hydrostatic pressure p(sub 1). For liquids the second-order elastic constants are C(sub 11) = A + p(sub 1), C(sub 12) = A -- p(sub 1), and the third-order constants are C(sub 111) = --(B + 5A + 3p(sub 1)), C(sub 112) = --(B + A -- p(sub 1)), and C(sub 123) = A -- B -- p1, where A and B are the Beyer expansion coefficients in the liquid equation of state. For ideal gases the second order constants are C(sub 11) = p(sub 1)gamma + p9sub 1), C(sub 12) = p(sub 1)gamma -- p(sub 1), and the third-order constants are C(sub 111) = p(sub 1)(gamma(2) + 4gamma + 3), C(sub 112) = --p(sub 1)(gamma(2) -- 1), and C(sub 123) = --p(sub 1) (gamma(2) -- 2gamma + 1), where gamma is the ratio of specific heats. The inequality of C(sub 11) and C(sub 12) results in a nonzero shear constant C(sub 44) = (1/2)(C(sub 11) C(sub 12)) = p(sub 1) for both liquids and gases. For water at standard temperature and pressure the ratio of terms p1/A contributing to the second-order constants is approximately 4.3 x 10(-5). For atmospheric gases the ratio of corresponding terms is approximately 0.7. Analytical expressions that include initial stresses are derived for the material 'nonlinearity parameters' associated with harmonic generation and acoustoelasticity for fluids and solids of arbitrary crystal symmetry. The expressions are used to validate the relationships for the elastic constants of fluids.

  14. 26 CFR 44.4412-1 - Registration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... receive wagers. As to a change of address, see § 44.4905-2. (c) Time and place for filing Form 11-C. For... return on Form 11-C. For provisions relating to the general requirement for filing a return, see § 44.6011(a)-1. (b) Information to be reported on Form 11-C. (1) Every person required to make a return on...

  15. Test of parameter-free local pseudopotential for the study of dynamical elastic constants - Cu as a prototype

    NASA Astrophysics Data System (ADS)

    Bhatia, K. G.; Vyas, S. M.; Patel, A. B.; Bhatt, N. K.; Vyas, P. R.; Gohel, V. B.

    2018-05-01

    Using parameter-free (first principles local) pseudopotential, in the present communication we have calculated dynamical elastic constants (C11, C12 and C44), bulk modulus (B), shear modulus (µp), Young's modulus (Y) and Poisson's ratio (σ) in long wavelength limit. Our computed results are well agreed for C44 and B with experiment and with other theoretical results obtained within framework of second order perturbation pseudopotential theory. From the present study we conclude that pseudopotential used contain s-p hybridization and no extra term is required to account core-core repulsion.

  16. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 8. (General Contractor, Inc.-H and H Industrial Instruments)

    DTIC Science & Technology

    1989-01-01

    4C>Qa0 QQ aQD1> 4 0-4 - 4 - 4-o4 - 4 - 4->Q0 o00 > > > Cell . 0c4 IC1 l’(0< 40 I O O O O O O O O O O O O O O O O O O O (n3IU 1 m C𔃾 11.0 C3 xO O O O O...In it el4 យ C-4 il.J 4 44 4 4 4 44 4 4 4 X"""NI (D00)0) 000 (0 (04C) 1 U0I co-4 1I N4 4 4 4 4 44 4 4 4 r44 QNO 40 m NQ Is .1 II 0-4 11 0 0 0 0 00 0 0...C C II C0 1- 0 1- 11 to I MN 11 - 1-4 iil Wcs n z 2 i Z - I WNC 110010>C 20 C O>l 0 a 2 - 0- Oil El4 eJ 1140 1- 0 C’ I-i-i c Il linN - I it4 ". z - I

  17. Allatoona Lake Destratification Equipment Test Appendix C: Operational and Water Quality Data 1970

    DTIC Science & Technology

    1971-02-01

    K PN 1%1 %NVNNN .4. - ~32 ft a 40 *aaepm C * **.4v4 m.m 921, aaaa~aa~~ a .a ;z - 40. .94.8*am m4 .4a iP P. td * ’* - a I we C. 0e . .. aa.aaa a a ma...Itac.mmC V in -~ a 44 44eI 2.4 44 14 4(dP 4 .444 W ..* 4 - 0 4mado 12 tv W cm m w vq a ama 40 4 a aD am a as *0 Ia a mamm M f 4Z2 .% ,!P .4 44 td 44t 4...As4CE3 i - i w N(~ Lo-N 4 m* m NPA gN x I’. .4.4..4.m4.4C a z in 00110 ob . *4....d 4bd bd b4 V4 .4 IN T o1 U.4 Loa U1- U..0 AnI d% -’Sd II 3p 4 44. 4 ~~f

  18. Fundamental piezo-Hall coefficients of single crystal p-type 3C-SiC for arbitrary crystallographic orientation

    NASA Astrophysics Data System (ADS)

    Qamar, Afzaal; Dao, Dzung Viet; Phan, Hoang-Phuong; Dinh, Toan; Dimitrijev, Sima

    2016-08-01

    Piezo-Hall effect in a single crystal p-type 3C-SiC, grown by LPCVD process, has been characterized for various crystallographic orientations. The quantified values of the piezo-Hall effect in heavily doped p-type 3C-SiC(100) and 3C-SiC(111) for different crystallographic orientations were used to obtain the fundamental piezo-Hall coefficients, P 12 = ( 5.3 ± 0.4 ) × 10 - 11 Pa - 1 , P 11 = ( - 2.6 ± 0.6 ) × 10 - 11 Pa - 1 , and P 44 = ( 11.42 ± 0.6 ) × 10 - 11 Pa - 1 . Unlike the piezoresistive effect, the piezo-Hall effect for (100) and (111) planes is found to be independent of the angle of rotation of the device within the crystal plane. The values of fundamental piezo-Hall coefficients obtained in this study can be used to predict the piezo-Hall coefficients in any crystal orientation which is very important for designing of 3C-SiC Hall sensors to minimize the piezo-Hall effect for stable magnetic field sensitivity.

  19. Elastic constants of calcite

    USGS Publications Warehouse

    Peselnick, L.; Robie, R.A.

    1962-01-01

    The recent measurements of the elastic constants of calcite by Reddy and Subrahmanyam (1960) disagree with the values obtained independently by Voigt (1910) and Bhimasenachar (1945). The present authors, using an ultrasonic pulse technique at 3 Mc and 25??C, determined the elastic constants of calcite using the exact equations governing the wave velocities in the single crystal. The results are C11=13.7, C33=8.11, C44=3.50, C12=4.82, C13=5.68, and C14=-2.00, in units of 1011 dyncm2. Independent checks of several of the elastic constants were made employing other directions and polarizations of the wave velocities. With the exception of C13, these values substantially agree with the data of Voigt and Bhimasenachar. ?? 1962 The American Institute of Physics.

  20. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 1 (101 International-Allied Signal Inc)

    DTIC Science & Technology

    1990-01-01

    C3 I’l- (D m cn ’t C14 r- In -I r c,) r- r-- c> r-- " cj -4 in tD I-- cy) a) In -T -4 to I rj it (74 -It 0 m t Cl) r- -4 -1 11 m (71) f- C1.1 * lr In t...4-4 -4---4 "’ -. ICL,_ 400 40 a Z o InZ -0 02zz LA- LAL uI, LI L, ,L L . 4BD . 110 (1 ( 0 0> 0 0 Q-JIf 𔃾(1 𔃺- C(1( LA - r l) D-4 -44 m-4 00 LA-I...It co 00 a (D (D C> C\\j c"I c"I M C1) U’) (D CD to C,4 C> 0 C> Cj 1 C) (D C, 11 C., 0 r, CY) Of In M CMD M> In < M < r" -4 -1 -4 tD C> C. C) (JO (D C

  1. Organic compound composition in soil and sediments collected in Jackson, Mississippi.

    PubMed

    Gołębiowski, Marek; Stepnowski, Piotr; Hemmingway, Tometrick; Leszczyńska, Danuta

    2016-01-01

    The aim of our study was to identify organic pollutants found in soil and sediment samples collected within the Jackson, MS metropolitan area. The chemical characterization of the organic compound fractions in soil and sediment samples was carried out by separating the organic fraction using column chromatography (CC) and quantitatively analyzing the polycyclic aromatic hydrocarbons (PAHs), n-alkanes and other organic compounds using gas chromatography-electron impact mass spectrometry (GC-MS). Fifty-six compounds were identified and quantified in the soil samples and 33 compounds were identified and quantified in the sediment samples. The PAHs, n-alkanes and other organic compound profiles in the soil and sediment samples were compared. The percentage contents of the organic compounds in the soil samples were very diverse (from traces to 12.44 ± 1.47%). The compounds present in the highest concentrations were n-alkanes: n-C31 (12.44 ± 1.47%), n-C29 (11.64 ± 1.21%), and n-C33 (8.95 ± 1.08%). The components occurring in smaller quantities (from 1% to 5%) were 2 PAHs (fluoranthene 1.28 ± 0.25%, pyrene 1.16 ± 0.20%), 10 n-alkanes from n-C21 (1.25 ± 0.29%) to n-C32 (2.67 ± 0.52%) and 11 other compounds (e.g., 2-pentanol, 4-methyl (3.33 ± 0.44%), benzyl butyl phthalate (4.25 ± 0.59%), benzenedicarboxylic acid (1.14 ± 0.08%), ethane, 1,1-diethoxy (3.15 ± 0.41) and hexadecanoic acid (2.52 ± 0.34). The soil samples also contained 30 compounds present in concentrations <1% (e.g., anthracene (0.13 ± 0.04%), n-C20 (0.84 ± 0.21%) and acetic acid (0.12 ± 0.04%). The compounds present in the highest concentrations in the sediment samples were PAHs: pyrene (7.73 ± 1.15%) and fluoranthene (6.23 ± 1.07%) and n-alkanes: n-C31 (6.74 ± 1.21%), n-C29 (6.65 ± 0.98%) and n-C27 (6.13 ± 1.09%). The remaining organic compounds were present in smaller quantities (< 5%).

  2. Single-crystal elastic properties of aluminum oxynitride (AlON) from brillouin scattering

    DOE PAGES

    Satapathy, Sikhanda; Ahart, Muhtar; Dandekar, Dattatraya; ...

    2016-01-19

    The Brillouin light-scattering technique was used to determine experimentally the three independent elastic constants of cubic aluminum oxynitride at the ambient condition. They are C 11=334.8(±1.8) GPa, C 12=164.4(± 1.2) GPa, and C 44=178.6(± 1.1) GPa. Its bulk modulus is 221.2 GPa. The magnitude of Zener anisotropic ratio is 2.1 similar to other spinels. Here, the anisotropic nature of the material is shown by a large variation in the Young’s modulus and Poisson’s ratio with crystallographic directions. The material was found to be auxetic in certain orientations.

  3. Ab initio elastic tensor of cubic Ti0.5Al0.5N alloys: Dependence of elastic constants on size and shape of the supercell model and their convergence

    NASA Astrophysics Data System (ADS)

    Tasnádi, Ferenc; Odén, M.; Abrikosov, Igor A.

    2012-04-01

    In this study we discuss the performance of the special quasirandom structure (SQS) method in predicting the elastic properties of B1 (rocksalt) Ti0.5Al0.5N alloy. We use a symmetry-based projection technique, which gives the closest cubic approximate of the elastic tensor and allows us to align the SQSs of different shapes and sizes for a comparison in modeling elastic tensors. We show that the derived closest cubic approximate of the elastic tensor converges faster with respect to SQS size than the elastic tensor itself. That establishes a less demanding computational strategy to achieve convergence for the elastic constants. We determine the cubic elastic constants (Cij) and Zener's type elastic anisotropy (A) of Ti0.5Al0.5N. Optimal supercells, which capture accurately both the configurational disorder and cubic symmetry of elastic tensor, result in C11=447 GPa, C12=158 GPa, and C44=203 GPa with 3% of error and A=1.40 with 6% of error. In addition, we establish the general importance of selecting proper SQS with symmetry arguments to reliably model elasticity of alloys. We suggest the calculation of nine elastic tensor elements: C11, C22, C33, C12, C13, C23, C44, C55, and C66, to analyze the performance of SQSs and predict elastic constants of cubic alloys. The described methodology is general enough to be extended for alloys with other symmetry at arbitrary composition.

  4. Elastic properties of uniaxial-fiber reinforced composites - General features

    NASA Astrophysics Data System (ADS)

    Datta, Subhendu; Ledbetter, Hassel; Lei, Ming

    The salient features of the elastic properties of uniaxial-fiber-reinforced composites are examined by considering the complete set of elastic constants of composites comprising isotropic uniaxial fibers in an isotropic matrix. Such materials exhibit transverse-isotropic symmetry and five independent elastic constants in Voigt notation: C(11), C(33), C(44), C(66), and C(13). These C(ij) constants are calculated over the entire fiber-volume-fraction range 0.0-1.0, using a scattered-plane-wave ensemple-average model. Some practical elastic constants such as the principal Young moduli and the principal Poisson ratios are considered, and the behavior of these constants is discussed. Also presented are the results for the four principal sound velocities used to study uniaxial-fiber-reinforced composites: v(11), v(33), v(12), and v(13).

  5. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 15 (Mountain States Caulking Inc-Pangborn Corp)

    DTIC Science & Technology

    1990-01-01

    I 4 i (0> 0) (0 ?-- CoN 4C.A<>(0 0 9 3 020 i3f 04--4---0 -4 aNN C 0 VO N4 04000C0 33 3020 goN)L0(?-C 0 Of Co 0 ~ )0) 0)0) --- 03(3 C7(0 0)4 I3 3 02...M I -IO1 1 4NnInC0a laII0.I :Tl otIc 00o4-4 LIOr CO > -- 4-4 0-0-4 N m1 it-11m il C)I- o 00) 111 t 11 L- -4 0004 f Oi0 C ~ I -444- CON I NT N CL L...7) 0) I () 00 J! 0) 0)J 0. ) 0) 0) 0) .1  402 C 40 0 H 0 F- 0 0 H 344 if 2 I11-4" -I 0 a- 1- 1 0 0 444I CON 11I <- H < 044 : n 44 41 4cc 04E𔃺in

  6. 4,4'-Bipyridine-pyroglutamic acid (1/2).

    PubMed

    Arman, Hadi D; Kaulgud, Trupta; Tiekink, Edward R T

    2009-10-31

    In the title co-crystal, C(10)H(8)N(2)·2C(5)H(7)NO(3), the 4,4'-bipyridine mol-ecule [dihedral angle between the pyridine rings = 36.33 (11)°] accepts O-H⋯N hydrogen bonds from the two pyroglutamic (pga) acid mol-ecules. The pga mol-ecules at each end of the trimeric aggregate self-associate via centrosymmetric eight-membered amide {⋯HNCO}(2) synthons, so that the crystal structure comprises one-dimensional supra-molecular chains propagating in [13]. C-H⋯O and π-π stacking inter-actions [centroid-centroid separation = 3.590 (2) Å] consolidate the structure.

  7. Atlantic and Mediterranean Tables of Communication Station Azimuths and LORAN-C Station Azimuths and Distances.

    DTIC Science & Technology

    1979-11-01

    4441* .411(( ..*4.6** 00 00 11 (C) 0941 , o c01 M 0 m a 9C N444** coo*4 *44 * *4p4 0C m m . LOC - .8 *410.4 1-12 "N*4 ".-1 1* 0.1-8(1. " - a 01...4r Zfl -1 1 -1 .N 0 0 O ’oC . - T ~ ~ ~ ~ ~ N N P.Pl rw r 4p -- -D- -ccgo Q --(. 0-o - - - . cc0 00 Go~ ~ o0t GDC 0a r- N.*Or I*OI- o."~ aL~04 0 YNV

  8. Priming the Tumor Immune Microenvironment Improves Immune Surveillance of Cancer Stem Cells and Prevents Cancer Recurrence

    DTIC Science & Technology

    2013-10-01

    YANG,a DEBBIE LIAO,b CONG CHEN,c YAN LIU,c TSUNG-HSIEN CHUANG,d RONG XIANG,a DOROTHY MARKOWITZ,b RALPH A. REISFELD,b YUNPING LUOb,c aDepartment of...tumor stem cells. Cancer Cell 2007;11:69–82. 27 Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res...polarization and vessel normalization through downregulation of PlGF. Cancer Cell 2011; 19: 31–44. 12 Murdoch C, Lewis CE. Macrophage migration and gene

  9. Prime Contract Awards by State or Country, Place and Contractor. Part 12 (Pelham Manor, New York - New Knoxville, Ohio), FY1991

    DTIC Science & Technology

    1991-01-01

    ON 3S NOWo 0. 4o 1- 0: CI (n< .4444NN --- 11.1 IS I ON4 If =0 w 0 4 40 I-40 0 20 .J00000 4 1 it I ON4 If 11.5 1- 0 1-- r IN 00 10 "-4< -14 44 0 0 .1...4 S -4--4 -4-4 -4 -4 -4 Nli-4NNMC1 * 0.4 a :2Z 2 m =z 2 Z=ZZZZ2 2 2ZZz a ( 347 ) U 4444 < 4 0 0040000000 w ɘɜ a ON C4 0000CD00 00W<M 0000a400 c0 0 2

  10. North Atlantic OMEGA Navigation System Validation

    DTIC Science & Technology

    1980-07-21

    Southeast Coast of Greenland c. Small triangular area between Iceland and Norway Winter Night: a. Extreme western part of Gulf of Mexico b. Southeast ...00 I c c i . IA.. ........ . . AWA. ~ ~ -;....... ... ~ ~ % i lot, oil N Io .. .....-.. .... .... 1 11~ 11 1 1 Ji l II...IW **.~.**..***.*A P HU.:* .0 Oil .4* 3 v .-.... ~IM I, * *. *... , C*.*.... IL. JI IL’ as 04 ......... !’ . ~ ~ . . .2 *................ 914~ 44 44

  11. All Prime Contract Awards by State or Country, Place, and Contractor. Part 11 (Methuen, Mass-Winsted, Minnesota)

    DTIC Science & Technology

    1990-01-01

    4 N GAo (0 C2N 11 .12a- 0. ir El 02- 110L 0 Ix .m I M -4 If CU U.w 1 M-4 it 0. .NNj00 00 00 000 ( 0e(ON0r-C400 Dc4c0c)c nr - 4 o-4 - 4 ( or- 41.n0...N N N NNIN NNNN""J.. .. "N6-Jt.. .. . .. .. 6% JINI oN IftG 4 0*’,fL N 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 444C 4 N -4j ca)0 0 IMZZ Z Z Z Z Z Z ZZ Z Z...M In c’) w o-4 um am aW-a4 a Gao Winul)U)U)) 00 1,17im)ala) L" 0 00 Q a (1) U ) n) U 0 ma 0-4 amcC) C(NNNN.N.NNNNNNN c3 ca-.- C)- CNN cQ w coo maaM

  12. All Prime Contract Awards by State or Country, Place, and Contractor. Part 20 (Fredericksburg Virginia-Springfield Virginia)

    DTIC Science & Technology

    1990-01-01

    a * Vs 4 NN- 4IN 00 c -10 Ina 0004C r) 0 r-s ON I CC#0) ot in --4 (no ifl0.-4 0-400 0Vs 00-I 0000 -400 EEq -E tun 04 1 0C) 1 44 4 VI 0004 Vs4<WIL ax...am4- N zzzzzzzzzzzzzzzzzzzzzz Wc 1 4-4 & Zaw *hf Mel of- 4o So atO it NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSi 11 1a ~ S 44 0O HNNNNNNNNNNNNNNNNC...4. 4.-I 0 3C11 1 M (V) N1 00 -000c 1-00 0) 0) 0 0 0 000) 0 ə 1(IM C) N 00.i 0000.i CMM..i 00 00 02 >-M 0) >-00000.i 0) H I tUN NOIL 4C 0 4C w 4C 4 00

  13. 30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....11(d)(2)(v); 808.14(c); 815.15(a); 816.41(d), .42(a)(7), .43, .44(b)(3), .46, .49, .52(a)(4), .53...), .43(e), .51-S(b), .52(a)(1), (2), .54, .65(f), .95(a), (b), .101(b)(1), .102(a), (g), .103, .104(a...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

  14. 30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....11(d)(2)(v); 808.14(c); 815.15(a); 816.41(d), .42(a)(7), .43, .44(b)(3), .46, .49, .52(a)(4), .53...), .43(e), .51-S(b), .52(a)(1), (2), .54, .65(f), .95(a), (b), .101(b)(1), .102(a), (g), .103, .104(a...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

  15. 30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....11(d)(2)(v); 808.14(c); 815.15(a); 816.41(d), .42(a)(7), .43, .44(b)(3), .46, .49, .52(a)(4), .53...), .43(e), .51-S(b), .52(a)(1), (2), .54, .65(f), .95(a), (b), .101(b)(1), .102(a), (g), .103, .104(a...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

  16. 30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....11(d)(2)(v); 808.14(c); 815.15(a); 816.41(d), .42(a)(7), .43, .44(b)(3), .46, .49, .52(a)(4), .53...), .43(e), .51-S(b), .52(a)(1), (2), .54, .65(f), .95(a), (b), .101(b)(1), .102(a), (g), .103, .104(a...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

  17. High Intensity Electro-Magnetic and Ultrasonic Effects on Inorganic Materials Behavior and Processing Held in Raleigh, North Carolina on 17-18 July 1989

    DTIC Science & Technology

    1990-02-01

    constants (KBar): C11 1800 C12 100 C44 260 <G> 430 405 Figure 2. 0 A SIMULATION OF CRYSTAL GROWTH By studying successively larger crystal fragments...Virginia, Charlottesville, VA 22901 Since before 1981, K. Lal and co-workers have studied effects of electr- ic fields on non-conductor crystals ...ultrasound attenuation studies can be made. Attenuation of the ultrasound is usually caused by crystal imperfections (mainly grain boundaries

  18. Threefold interweaving of (4,4) nets built from R(10)10(58) rings inthe hydrogen-bonded adduct 1,4-diazabicyclo

    PubMed

    Burchell; Ferguson; Lough; Glidewell

    2000-09-01

    The 1:1 adduct of 1,4-diazabicyclo[2.2.2]octane and 5-hydroxyisophthalic acid is a salt, [H(C(6)H(12)N(2))](+). [HOC(6)H(3)(COOH)COO](-) or C(6)H(13)N(2)(+).C(8)H(5)O(5)(-). The ions are linked by three types of hydrogen bond, i.e. N-H.O, O-H.O and O-H.N, into continuous two-dimensional (4,4) nets built from a single type of R(10)(10)(58) ring. Six independent sheets of this type make up the structure and these are interwoven in sets of three.

  19. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 23. (Greenland-Morocco)

    DTIC Science & Technology

    1988-01-01

    8217-4 -4 4 -4 4 -4 aOO 0 I CI) m0-4-4m’ -4-4 -4 -4-4--4 in Ln in -4 U) U) 800-4 m c) c)0’)’ C’)0 m’ enC ) ’ C) C’) Cm -4 -I C11 1 0-40 Do( I0U-40 1 -4...0V)Ln U’ L nAnL) 0 0 l-0 z00000o OLL LADO viV LnA ,L UI m 0 20 0 1 102-4 I JOOOcOOOOoOOOO I 0 D ZOOOOO. *- qa U40 UlA1ILAiln0 00 I-12. 100000000 ZO

  20. Chemical Bonding, Interdiffusion and Electronic Structure at InP, GaAs, and Si-Metal Interfaces.

    DTIC Science & Technology

    1985-10-01

    4. H.H. Wieder, J. Vac. Sci. Technol. 15, 1498 (1978). C. 5. W.E. Spicer, 1. Lindau, P. Skeath, C.Y. Su, and P. Chye , Phys. Rev. Lett. 44, 10 420...Spicer, Solid State Electron. 28 307 (1985). 25. N. Newman, K.K. Chin , W.G. Petro, T. Kendelewicz, M.D. Williams, C.E. McCants, and W.E. Spicer, J. Vac...Technol. 19, 661 (1981). 11. Y. Shapira, L.J. Brillson and A. Heller, J. Vac. Sci. U Technol., Al, 766 (1983). 12. P.W. Chye , I. Lindau, P. Pianetta, C.M

  1. Development of a Physical Employment Testing Battery for Infantry Soldiers: 11B Infantryman and 11C Infantryman-Indirect Fire

    DTIC Science & Technology

    2015-12-01

    43 1.9 Images of Move Under Direct Fire (Task 10) 44 1.10 Engage Targets with a .50 Caliber M2 Machine Gun (Task 12) 45 1.11 Image of Lay a...Caliber M2 Machine Gun While wearing a fighting load (approximately 83 lb) and working as a member of a two-person team, Soldiers lifted and carried the... M2 HB Machine Gun with tripod (153 lb) a distance of 10 m. Army Standard: Successful completion of the task 13. Emplace Base Plate (11C

  2. Dissociative photoionization of 1,3-butadiene: experimental and theoretical insights.

    PubMed

    Fang, Wenzheng; Gong, Lei; Zhang, Qiang; Shan, Xiaobin; Liu, Fuyi; Wang, Zhenya; Sheng, Liusi

    2011-05-07

    The vacuum-ultraviolet photoionization and dissociative photoionization of 1,3-butadiene in a region ∼8.5-17 eV have been investigated with time-of-flight photoionization mass spectrometry using tunable synchrotron radiation. The adiabatic ionization energy of 1,3-butadiene and appearance energies for its fragment ions, C(4)H(5)(+), C(4)H(4)(+), C(4)H(3)(+), C(3)H(3)(+), C(2)H(4)(+), C(2)H(3)(+), and C(2)H(2)(+), are determined to be 9.09, 11.72, 13.11, 15.20, 11.50, 12.44, 15.15, and 15.14 eV, respectively, by measurements of photoionization efficiency spectra. Ab initio molecular orbital calculations have been performed to investigate the reaction mechanism of dissociative photoionization of 1,3-butadiene. On the basis of experimental and theoretical results, seven dissociative photoionization channels are proposed: C(4)H(5)(+) + H, C(4)H(4)(+) + H(2), C(4)H(3)(+) + H(2) + H, C(3)H(3)(+) + CH(3), C(2)H(4)(+) + C(2)H(2), C(2)H(3)(+) + C(2)H(2) + H, and C(2)H(2)(+) + C(2)H(2) + H(2). Channel C(3)H(3)(+) + CH(3) is found to be the dominant one, followed by C(4)H(5)(+) + H and C(2)H(4)(+) + C(2)H(2). The majority of these channels occur via isomerization prior to dissociation. Transition structures and intermediates for those isomerization processes were also determined.

  3. The elastic constants of San Carlos olivine to 17 GPa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abramson, E.H.; Brown, J.M.; Slutsky, L.J.

    1997-06-01

    All elastic constants, the average bulk and shear moduli, and the lattice parameters of San Carlos olivine (Fo{sub 90}) (initial density 3.355gm/cm{sup 3}) have been determined to a pressure of 12 GPa at room temperature. Measurements of c{sub 11}, c{sub 33}, c{sub 13}, and c{sub 55} have been extended to 17 GPa. The pressure dependence of the adiabatic, isotropic (Hashin-Shtrikman bounds) bulk modulus, and shear modulus may be expressed as K{sub HS}=129.4+4.29P and by G{sub HS}=78+1.71P{minus}0.027P{sup 2}, where both the pressure and the moduli are in gigapascals. The isothermal compression of olivine is described by a bulk modulus given asmore » K{sub T}=126.3+4.28P. Elastic constants other than c{sub 55} can be adequately represented by a linear relationship in pressure. In the order (c{sub 11},c{sub 12},c{sub 13},c{sub 22},c{sub 23},c{sub 33},c{sub 44},c{sub 55},c{sub 66}) the 1 bar intercepts (gigapascal units) are (320.5, 68.1, 71.6, 196.5, 76.8, 233.5, 64.0, 77.0, 78.7). The first derivatives are (6.54, 3.86, 3.57, 5.38, 3.37, 5.51, 1.67, 1.81, 1.93). The second derivative for c{sub 55} is {minus}0.070GPa{sup {minus}1}. Incompressibilities for the three axes may also be expressed as linear relationships with pressure. In the order of {bold a, b}, and {bold c} axes the intercepts in gigapascals are (547.8, 285.8, 381.8) and the first derivatives are (20.1, 12.3, 14.0).{copyright} 1997 American Geophysical Union« less

  4. Ring opening and carbonylation of 3,3-dimethylthietane ligands in ruthenium carbonyl cluster complexes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, R.D.; Belinski, J.A.; Yamamoto, J.H.

    1992-10-01

    When heated to 97{degrees}C, the complex Ru{sub 4}(CO){sub 12}[{mu}-SCH{sub 2}CMe{sub 2}CH{sub 2}]2 (1) was transformed into two new hexaruthenium cluster complexes, Ru{sub 6}(CO){sub 13}({mu}{sub 3}-SCH{sub 2}CMe{sub 2}CH{sub 2}){sub 4} (2) and Ru{sub 6}(CO){sub 12}({mu}-SCH{sub 2}CMe{sub 2}CH{sub 2})({mu}{sub 3}-SCH{sub 2}CMe{sub 2}CH{sub 2}){sub 3}[{mu}{sub 3}-SCH{sub 2}C(Me)(CH{sub 2})CH{sub 2}] ({mu}-H) (3), that contain four and five ring-opened 3,3-dimethylthietane (3,3-DMT) ligands, respectively. In compound 3 one of the ring-opened DMT ligands has also undergone a CH activation on one of the methyl groups. Compound 2 reacts with additional 3,3-DMT at 97{degrees}C to form 3 in 18% yield. When treated with CO at 95{degrees}C (500more » psi), compound 2 yielded 4,4-dimethylthiobutyrolactone and Ru{sub 3}(CO){sub 12}. It was also found that the complex Os{sub 3}(CO){sub 11-}(SCH{sub 2}CMe{sub 2}CH{sub 2}C{double_bond}O) (4) yields 4,4-dimethylthiobutyrolactone when treated with CO at 120{degrees}C (1200 psi). Crystal data for 2: space group P2{sub 1}/n, {alpha} = 22.652 (7) A, {beta} = 11.712 (2) A, c = 19.965 (6) A, {Beta} = 115.75 (2){degrees} Z = 4, 3665 reflections, R = 0.021. Crystal data for 3: space group P2{sub 1}/c, {alpha} = 17.332 (8) A, {Beta} = 14.668 (9) A, c = 19.823 (9) A, {Beta} = 91.27 (4){degrees}, Z = 4, 1875 reflections, R = 0.050. 13 refs., 2 figs., 13 refs.« less

  5. All Prime Contract Awards by State or Country, Place, and Contractor. Part 4 (San Diego, California-Victorville, California)

    DTIC Science & Technology

    1990-01-01

    4 N 41, <- ɘ) 41 - <-40 MI C-4 04 N NNNNN04N N\\CN 0 40 40 -4 ’-4 0) 0 00C Oi MC-4 Ilr-4--44l"I4.4- -1.44 -f-4 1- 0 Coco c)0 41 W C oc NOWO H1-1 W...zoo4 Cn-44.-44-4- 0)0000o00000000 =1310- it I CI t 347 ) 00 NC- o 7 f40 -100 00(0) 2 1((( (0(0 a)0 _ NO) 0 OOOOOOOOO))C)0)0)C M 14 04 1-0 1- < 0 CA: 0Z

  6. Training Extract Historian AFSC: 791X2.

    DTIC Science & Technology

    1985-09-01

    AW-RI61 I"N TRINING EXTRACT HISTORIAN AFSC: 9X2(U) RIR FORCE 1/2OCCUPATIONAL NERSURENENT CENTER RANDOLPH RFI TX SEP 05 UNCLASSIFIED F/O 519 ML ILhE...99919 :~~00 @04 0 00 mOto IIP-M’ ~ 1 1 F PIA@. .0 at0 Noost.4. NO~ -N C .ON.* 4 44 C C -Na d 0 *M -ON FM Ř ’a. fn . 10 00*0c f. - - - F 2 a. 0 �...CP.N INNN &. 4 . W! I.i. ID w~* At. *a -D x: T T. 6, +4 ao 11U a4 l.Ot I I O-AI61 IN TRAINING EXTRACT HISTORIAN AFSC: M9UM AIR FORCE 12I OCCUPATIONAL

  7. Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.

    PubMed

    Hilton, Hugo G; Blokhuis, Jeroen H; Guethlein, Lisbeth A; Norman, Paul J; Parham, Peter

    2017-03-01

    KIR2DP1 is an inactive member of the human lineage III KIR family, which includes all HLA-C-specific receptor genes. The lethal, and only, defect in KIR2DP1 is a nucleotide deletion in codon 88. Fixed in modern humans, the deletion is also in archaic human genomes. KIR2DP1 is polymorphic, with dimorphism at specificity-determining position 44. By repairing the deletion, we resurrected 11 alleles of KIR2DP1 F , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1 F with lysine 44 recognized C1 + HLA-C, whereas T44-KIR2DP1 F recognized C2 + HLA-C. Dimorphisms at 12 other KIR2DP1 F residues modulate receptor avidity or signaling. KIR2DP1 and KIR2DL1 are neighbors in the centromeric KIR region and are in tight linkage disequilibrium. Like KIR2DL1 , KIR2DP1 contributed to CenA and CenB KIR haplotype differences. Encoded on CenA , C1-specific K44-KIR2DP1 F were stronger receptors than the attenuated C2-specific T44-KIR2DP1 F encoded on CenB The last common ancestor of humans and chimpanzees had diverse lineage III KIR that passed on to chimpanzees but not to humans. Early humans inherited activating KIR2DS4 and an inhibitory lineage III KIR , likely encoding a C1-specific receptor. The latter spawned the modern family of HLA-C receptors. KIR2DP1 F has properties consistent with KIR2DP1 F having been the founder gene. The first KIR2DP1 F alleles encoded K44-C1 receptors; subsequently KIR2DP1 F alleles encoding T44-C2 receptors evolved. The emergence of dedicated KIR2DL2/3 and KIR2DL1 genes encoding C1 and C2 receptors, respectively, could have led to obsolescence of KIR2DP1 F Alternatively, pathogen subversion caused its demise. Preservation of KIR2DP1 F functional polymorphism was a side effect of fixation of the deletion in KIR2DP1 F by micro gene conversion. Copyright © 2017 by The American Association of Immunologists, Inc.

  8. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (HSU Ronald Construction Co. - Jacobson & Son Yard Service). Part 10

    DTIC Science & Technology

    1994-03-01

    WCo toJ Il I OOt 0 CL I I 004*LaJ 11 On 11W 00t) II o4 4 4 4 4 ov4 44 4 4 4 444 44 If 00’E01 M൴ 44 44 114 COM it L)UUUUNN 440 4000000 00. NON NI N44...N E I-I 1 0CDO II-.00-40000000 0000000-. 000-. 00 00040 0-.40 U:1-0C)C V V f)0C)mMC v V mI M M0V II CNNN Nr)NMC) YC V ) N NV4 C)M Y MmM Mm0il I Com 2...4- --N4-4 -4.MM-4 -4.ý -4 11 100I 00 P (0.-00iNDOmr. -QDO coM L i i i i i iN i(D 00L0 D(D i(00000MM NM Mr fMMr. M 0MMr.%WO 0W 0aW 11 -4 (0 0 II-cj 1 a

  9. Short communication: Genetic study of methane production predicted from milk fat composition in dairy cows.

    PubMed

    van Engelen, S; Bovenhuis, H; Dijkstra, J; van Arendonk, J A M; Visker, M H P W

    2015-11-01

    Dairy cows produce enteric methane, a greenhouse gas with 25 times the global warming potential of CO2. Breeding could make a permanent, cumulative, and long-term contribution to methane reduction. Due to a lack of accurate, repeatable, individual methane measurements needed for breeding, indicators of methane production based on milk fatty acids have been proposed. The aim of the present study was to quantify the genetic variation for predicted methane yields. The milk fat composition of 1,905 first-lactation Dutch Holstein-Friesian cows was used to investigate 3 different predicted methane yields (g/kg of DMI): Methane1, Methane2, and Methane3. Methane1 was based on the milk fat proportions of C17:0anteiso, C18:1 rans-10+11, C18:1 cis-11, and C18:1 cis-13 (R(2)=0.73). Methane2 was based on C4:0, C18:0, C18:1 trans-10+11, and C18:1 cis-11 (R(2)=0.70). Methane3 was based on C4:0, C6:0, and C18:1 trans-10+11 (R(2)=0.63). Predicted methane yields were demonstrated to be heritable traits, with heritabilities between 0.12 and 0.44. Breeding can, thus, be used to decrease methane production predicted based on milk fatty acids. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  10. Detections of Long Carbon Chains CH_{3}CCCCH, C_{6}H, LINEAR-C_{6}H_{2} and C_{7}H in the Low-Mass Star Forming Region L1527

    NASA Astrophysics Data System (ADS)

    Araki, Mitsunori; Takano, Shuro; Sakai, Nami; Yamamoto, Satoshi; Oyama, Takahiro; Kuze, Nobuhiko; Tsukiyama, Koichi

    2017-06-01

    Carbon chains in the warm carbon chain chemistry (WCCC) region has been searched in the 42-44 GHz region by using Green Bank 100 m telescope. Long carbon chains C_{7}H, C_{6}H, CH_{3}CCCCH, and linear-C_{6}H_{2} and cyclic species C_{3}H and C_{3}H_{2}O have been detected in the low-mass star forming region L1527, performing the WCCC. C_{7}H was detected for the first time in molecular clouds. The column density of C_{7}H is derived to be 6.2 × 10^{10} cm^{-2} by using the detected J = 24.5-23.5 and 25.5-24.5 rotational lines. The ^{2}Π_{1/2} electronic state of C_{6}H, locating 21.6 K above the ^{2}Π_{3/2} electronic ground state, and the K_a = 0 line of the para species of linear-C_{6}H_{2} were also detected firstly in molecular clouds. The column densities of the ^{2}Π_{1/2} and ^{2}Π_{3/2} states of C_{6}H in L1527 were derived to be 1.6 × 10^{11} and 1.1 × 10^{12} cm^{-2}, respectively. The total column density of linear-C_{6}H_{2} is obtained to be 1.86 × 10^{11} cm^{-2}. While the abundance ratios of carbon chains in between L1527 and the starless dark cloud Taurus Molecular Cloud-1 Cyanopolyyne Peak (TMC-1 CP) have a trend of decrease by extension of carbon-chain length, column densities of CH_{3}CCCCH and C_{6}H are on the trend. However, the column densities of linear-C_{6}H_{2}, and C_{7}H are as abundant as those of TMC-1 CP in spite of long carbon chain, i.e., they are not on the trend. The abundances of linear-C_{6}H_{2} and C_{7}H show that L1527 is rich for long carbon chains as well as TMC-1 CP.

  11. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Norwich Vermont - Melrose Virginia)

    DTIC Science & Technology

    1993-01-01

    4 11 0.:000000000 wo~ 0.000u Woo0 1,000 0 - 0 -j ifw IWcO-I4 1 -4 -4 co 00 co00 NNNN " ( NIB -I."-< ൴ 44< < <(o0(D0(to(D0(o(D0(0 សNC"" is C3 -4 (7...a 0 0 C), CD, a a a 0 0 0 0 a a C. C> (n) C, 10 C> a C> a .0 U) III m I mclco< 11 C.)MMM C,) M C1) M I mc>co<:: Cacao co C43 Coa c Q 0 0 0 10 C. Q Q 0...i LA1)0)0 (-mir-- (c)4c LAA) o a ( De 400 M t-.) --.?-- 1 --4 of a < CON ma 00 o(0 0100 ()a )01C)0m)0000oo0 ;4100 40 <D 004 44 14 0V)CI0000 -4I mm. 1

  12. Crystal structure of methyl 3'-benzamido-4'-(4-meth-oxy-phen-yl)-1'-methyl-spiro-[indeno-[1,2-b]quinoxaline-11,2'-pyrrolidine]-3'-carboxyl-ate.

    PubMed

    Chandralekha, Kuppan; Sureshbabu, Adukamparai Rajukrishnan; Gavaskar, Deivasigamani; Lakshmi, Srinivasakannan

    2016-09-01

    In the title compound, C 35 H 30 N 4 O 3 , the spiro C atom connects the five-membered pyrrolidine ring and the indeno-quinoxaline ring system. The pyrrolidine ring adopts a twist conformation. An intra-molecular N-H⋯N inter-action between the amino group and the pyrazine ring is observed. In the crystal, mol-ecules are linked by a pairs of C-H⋯O hydrogen bonds, forming inversion dimers.

  13. A Monte Carlo Technique Suitable for Obtaining Complex Space System Reliability Confidence Limits from Component Test Data with Three Unknown Parameters.

    DTIC Science & Technology

    1982-12-01

    093 .031 .026 E 116,292 56,424 44,906 12,354 L.L.S. c 2280 802 351 OW Average k .360 .074* .022* .009* Slope f 116,892 51,187 35,276 8,318 Modified c...LE.O.)THEN gELY =1. RGE1=RGE 1.1 ELS E X (CT-C) /THETA)**KI IF(XeLTo20.)THE4. RErLY=EXP(-X) ELSE RELY=O. END IF E"’D IF RETURN EN) 66 I APPENDIX B

  14. Periodic trends in hexanuclear actinide clusters.

    PubMed

    Diwu, Juan; Wang, Shuao; Albrecht-Schmitt, Thomas E

    2012-04-02

    Four new Th(IV), U(IV), and Np(IV) hexanuclear clusters with 1,2-phenylenediphosphonate as the bridging ligand have been prepared by self-assembly at room temperature. The structures of Th(6)Tl(3)[C(6)H(4)(PO(3))(PO(3)H)](6)(NO(3))(7)(H(2)O)(6)·(NO(3))(2)·4H(2)O (Th6-3), (NH(4))(8.11)Np(12)Rb(3.89)[C(6)H(4)(PO(3))(PO(3)H)](12)(NO(3))(24)·15H(2)O (Np6-1), (NH(4))(4)U(12)Cs(8)[C(6)H(4)(PO(3))(PO(3)H)](12)(NO(3))(24)·18H(2)O (U6-1), and (NH(4))(4)U(12)Cs(2)[C(6)H(4)(PO(3))(PO(3)H)](12)(NO(3))(18)·40H(2)O (U6-2) are described and compared with other clusters of containing An(IV) or Ce(IV). All of the clusters share the common formula M(6)(H(2)O)(m)[C(6)H(3)(PO(3))(PO(3)H)](6)(NO(3))(n)((6-n)) (M = Ce, Th, U, Np, Pu). The metal centers are normally nine-coordinate, with five oxygen atoms from the ligand and an additional four either occupied by NO(3)(-) or H(2)O. It was found that the Ce, U, and Pu clusters favor both C(3i) and C(i) point groups, while Th only yields in C(i), and Np only C(3i). In the C(3i) clusters, there are two NO(3)(-) anions bonded to the metal centers. In the C(i) clusters, the number of NO(3)(-) anions varies from 0 to 2. The change in the ionic radius of the actinide ions tunes the cavity size of the clusters. The thorium clusters were found to accept larger ions including Cs(+) and Tl(+), whereas with uranium and later elements, only NH(4)(+) and/or Rb(+) reside in the center of the clusters.

  15. Anhydrous versus hydrated N4-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines: hydrogen bonding in two and three dimensions.

    PubMed

    Trilleras, Jorge; Quiroga, Jairo; Cobo, Justo; Marchal, Antonio; Nogueras, Manuel; Low, John N; Glidewell, Christopher

    2008-10-01

    Ten new N(4)-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines have been synthesized and the structures of nine of them are reported here, falling into two clear groups, those which are stoichiometric hydrates and those which crystallize in solvent-free forms. In each of N(4)-methyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(12)H(12)N(6) (I), N(4)-cyclohexyl-N(4)-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(12)H(18)N(6) (II), and N(4)-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(11)H(9)ClN(6) (III), the molecules are linked into hydrogen-bonded sheets. The molecules of 2-{4-(6-amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl}ethanol, C(11)H(17)N(7)O (IV), are linked into a three-dimensional framework, while the structure of N(4)-methyl-N(4)-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine monohydrate, C(13)H(14)N(6) x H(2)O (V), is only two-dimensional despite the presence of five independent hydrogen bonds. The stoichiometric hemihydrates N(4)-ethyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine hemihydrate, C(13)H(14)N(6) x 0.5 H(2)O (VI) and N(4)-(4-methoxyphenyl)-N(4)-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine hemihydrate, C(13)H(14)N(6)O x 0.5 H(2)O (VII), exhibit remarkably similar sheet structures, despite different space groups and Z' values, Z' = 0.5 in C2/c for (VI) and Z' = 1 in P1 for (VII). N(4)-4-Benzyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine monohydrate, C(18)H(16)N(6) x H(2)O (VIII), crystallizes with Z' = 2 in P2(1)/n, and the four independent molecular components are linked into sheets by a total of 11 intermolecular hydrogen bonds. The sheet structure in {4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine} ethanol hemisolvate hemihydrate, C(9)H(12)N(6).0.5C(2)H(6)O x 0.5 H(2)O (IX), is built from the pyrimidine and water components only; it contains eight independent hydrogen bonds, and it very closely mimics the sheets in (VI) and (VII); the ethanol molecules are pendent from these sheets. The N(4)-alkyl-N(4)-aryl-4-aminopyrazolopyrimidine molecules in (I), (V)-(VIII) all adopt very similar conformations, dominated in each case by an intramolecular C-H...pi(arene) hydrogen bond: this interaction is absent from (III) where the molecular conformation is entirely different and probably dominated by the intermolecular hydrogen bonds.

  16. Getting to goal in newly diagnosed type 2 diabetes using combination drug "subtraction therapy".

    PubMed

    Jennings, Anthony S; Lovett, Alexandra J; George, Tina M; Jennings, Jonathan S

    2015-09-01

    The treatment of newly diagnosed type 2 diabetes mellitus is diverse, with no clear consensus regarding the initial drug regimen or dosing to achieve optimal glycemic control. We treated 44 consecutive patients with newly diagnosed type 2 diabetes with maximally tolerated doses of pioglitazone 45 mg/day, metformin 1000-2000 mg/day, and repaglinide 1-4 mg before meals. The doses and drugs were subsequently decreased ("subtraction therapy") to achieve optimal glycemic control and minimize side effects. Three primary outcomes were measured: the short term HbA1c response, the long term HbA1c response, and the incidence of hypoglycemia. All 44 patients responded with a rapid, progressive decline in their HbA1c levels from 11.43±2.3% to 6.17±0.72% (101±25.1 mmol/mol to 44±7.9 mmol/mol) by three months, and remained stable thereafter. An HbA1c ≤7.0% (≤53 mmol/mol) was reached within 1-4 months in 42 of 44 patients, and in every patient by 12 months. Each patient's lowest HbA1c level, 5.65±0.6% (38±6.6 mmol/mol), was reached over 6.3±2.9 months. Patients with initial HbA1c levels >10% (>86 mmol/mol) (n=33) responded similarly as those with HbA1c levels <10% (<86 mmol/mol) (n=11). Combination drug therapy maintained HbA1c levels between 5.0 and 7.0% (31 and 53 mmol/mol) for up to 14.83 years. Only one clinically significant hypoglycemic event occurred during 261.08 person-years of follow-up. In our experience, combination drug "subtraction therapy" was safe and effective for treating all newly diagnosed type 2 diabetic patients. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Determination of mass density, dielectric, elastic, and piezoelectric constants of bulk GaN crystal.

    PubMed

    Soluch, Waldemar; Brzozowski, Ernest; Lysakowska, Magdalena; Sadura, Jolanta

    2011-11-01

    Mass density, dielectric, elastic, and piezoelectric constants of bulk GaN crystal were determined. Mass density was obtained from the measured ratio of mass to volume of a cuboid. The dielectric constants were determined from the measured capacitances of an interdigital transducer (IDT) deposited on a Z-cut plate and from a parallel plate capacitor fabricated from this plate. The elastic and piezoelectric constants were determined by comparing the measured and calculated SAW velocities and electromechanical coupling coefficients on the Z- and X-cut plates. The following new constants were obtained: mass density p = 5986 kg/m(3); relative dielectric constants (at constant strain S) ε(S)(11)/ε(0) = 8.6 and ε(S)(11)/ε(0) = 10.5, where ε(0) is a dielectric constant of free space; elastic constants (at constant electric field E) C(E)(11) = 349.7, C(E)(12) = 128.1, C(E)(13) = 129.4, C(E)(33) = 430.3, and C(E)(44) = 96.5 GPa; and piezoelectric constants e(33) = 0.84, e(31) = -0.47, and e(15) = -0.41 C/m(2).

  18. Linking preferred orientations to elastic anisotropy in Muderong Shale, Australia

    DOE PAGES

    Kanitpanyacharoen, Waruntorn; Vasin, Roman; Wenk, Hans -Rudolf; ...

    2015-01-01

    The significance of shales as unconventional hydrocarbon reservoirs, nuclear waste repositories, and geological carbon storage has opened new research frontiers in geophysics. Among many of its unique physical properties, elastic anisotropy has long been investigated by both experimental and computational approaches. Here we calculate elastic properties of Cretaceous Muderong Shale from Australia with a self-consistent averaging method based on microstructural information. The volume fraction and crystallographic preferred orientation distributions of constituent minerals are based on synchrotron X-ray diffraction experiments. Aspect ratios of minerals and pores, determined from scanning electron microscopy (SEM), are introduced in the self-consistent averaging. Our analysis suggestsmore » that phyllosilicates (i.e., illite-mica, illite-smectite, kaolinite, and chlorite) are dominant with ~70 vol.%. The shape of clay platelets displays an average aspect ratio of 0.05. These platelets are aligned parallel to the bedding plane with a rather high degree of preferred orientation. The estimated porosity at ambient pressure is ~17 vol.% and is divided into equiaxial pores and flat pores with an average aspect ratio of 0.01. Our model shows results (e.g. at pressure of ~50 MPa with C 11 = 26.3; C 13 =12.5; C 33 = 18.2; C 44 = 2.8; C 66 = 6.8 [GPa]) that compare satisfactorily with values derived from ultrasonic velocity measurements (C 11 = 26.6; C 13 = 16.2; C 33 = 18.3; C 44 = 4.5; C 66 = 8.8 [GPa]), confirming the validity and reliability of our approximations and averaging approach.« less

  19. Vertebral formula and congenital abnormalities of the vertebral column in rabbits.

    PubMed

    Proks, P; Stehlik, L; Nyvltova, I; Necas, A; Vignoli, M; Jekl, V

    2018-06-01

    The aim of this retrospective study of 330 rabbits (164 males, 166 females) was to determine different vertebral formulas and prevalence of congenital vertebral anomalies in rabbits from radiographs of the cervical (C), thoracic (Th), lumbar (L) and sacral (S) segments of the vertebral column. The number of vertebrae in each segment of vertebral column, position of anticlinal vertebra and localisation and type of congenital abnormalities were recorded. In 280/330 rabbits (84.8%) with normal vertebral morphology, seven vertebral formulas were identified: C7/Th12/L7/S4 (252/330, 76.4%), C7/Th12/L6/S4 (11/330, 3.3%), C7/Th13/L7/S4 (8/330, 2.4%), C7/Th12/L7/S5 (4/330, 1.2%), C7/Th12/L8/S4 (3/330, 0.9%), C7/Th12/L7/S6 (1/330, 0.3%) and C7/Th11/L7/S4 (1/330, 0.3%). The anticlinal vertebra was identified as Th10 in 56.4% of rabbits and Th11 in 42.4% of rabbits. Congenital spinal abnormalities were identified in 50/330 (15.2%) rabbits, predominantly as a single pathology (n=44). Transitional vertebrae represented the most common abnormalities (n=41 rabbits) in the thoracolumbar (n=35) and lumbosacral segments (n=6). Five variants of thoracolumbar transitional vertebrae were identified. Cervical butterfly vertebrae were detected in three rabbits. One rabbit exhibited three congenital vertebral anomalies: cervical block vertebra, thoracic hemivertebra and thoracolumbar transitional vertebra. Five rabbits exhibited congenital vertebral abnormalities with concurrent malalignment, specifically cervical kyphosis/short vertebra (n=1), thoracic lordoscoliosis/thoracolumbar transitional vertebrae (n=1), thoracic kyphoscoliosis/wedge vertebrae (n=2) and thoracolumbar lordoscoliosis/thoracolumbar transitional vertebrae/lumbosacral transitional vertebrae (n=1). These findings suggest that vertebral columns in rabbits display a wide range of morphologies, with occasional congenital malformations. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Stepwise positive association between APOA5 minor allele frequencies and increasing plasma triglyceride quartiles in random patients with hypertriglyceridemia of unclarified origin.

    PubMed

    Hadarits, Ferenc; Kisfali, Péter; Mohás, Márton; Maász, Anita; Sümegi, Katalin; Szabó, Melinda; Hetyésy, Katalin; Valasek, Andrea; Janicsek, Ingrid; Wittmann, István; Melegh, Béla

    2011-03-01

    Apolipoprotein A5 (ApoA5) gene and its protein product play a central role in the complex regulation of circulating triglyceride levels in humans. Naturally occurring variants of the apolipoprotein A5 gene have been associated with increased triglyceride levels and have been found to confer risk for cardiovascular diseases. In our study, four polymorphisms, the T-1131C, IVS3+G476A, T1259C, and C56G alleles of APOA5 were analyzed in a total of 436 patients by polymerase chain reaction-restriction fragment length polymorphism methods. The randomly selected patients were classified into four quartile (q) groups based on triglyceride levels (q1: TG<1.31 mmol/l; q2: 1.31-2.90 mmol/l; q3: 2.91-4.85 mmol/l; q4: TG>4.85 mmol/l). We observed significant stepwise increasing association between the four APOA5 minor allele carrier frequencies and plasma triglyceride quartiles: -1131C (q1: 4.44%; q2: 8.95%; q3: 12.9%; q4: 20.6%), IVS3 + 476A (q1: 4.44%; q2: 5.79%; q3: 11.1%; q4: 19.7%), 1259C (q1: 4.44%; q2: 6.84%; q3: 11.1%; q4: 20.6%) and 56G (q1: 5.64%; q2: 6.31%; q3: 11.16%; q4: 11.9%). The serum total cholesterol and high density lipoprotein-cholesterol levels also showed allele-dependent differences in the quartiles. The findings presented here revealed a special arrangement of APOA5 minor alleles in patients with different serum triglyceride ranges in Hungarians.

  1. Evidence for anisotropic polar nanoregions in relaxor Pb(Mg1/3Nb2/3)O3: A neutron study of the elastic constants and anomalous TA phonon damping in PMN

    NASA Astrophysics Data System (ADS)

    Stock, C.; Gehring, P. M.; Hiraka, H.; Swainson, I.; Xu, Guangyong; Ye, Z.-G.; Luo, H.; Li, J.-F.; Viehland, D.

    2012-09-01

    We use neutron inelastic scattering to characterize the acoustic phonons in the relaxor Pb(Mg1/3Nb2/3)O3 (PMN) and demonstrate the presence of a highly anisotropic damping mechanism that is directly related to short-range polar correlations. For a large range of temperatures above Tc˜210 K, where dynamic, short-range polar correlations are present, acoustic phonons propagating along [11¯0] and polarized along [110] (TA2 phonons) are overdamped and softened across most of the Brillouin zone. By contrast, acoustic phonons propagating along [100] and polarized along [001] (TA1 phonons) are overdamped and softened for a more limited range of wave vectors q. The anisotropy and temperature dependence of the acoustic phonon energy linewidth Γ are directly correlated with neutron diffuse scattering cross section, indicating that polar nanoregions are the cause of the anomalous behavior. The damping and softening vanish for q→0, i.e., for long-wavelength acoustic phonons near the zone center, which supports the notion that the anomalous damping is a result of the coupling between the relaxational component of the diffuse scattering and the harmonic TA phonons. Therefore, these effects are not due to large changes in the elastic constants with temperature because the elastic constants correspond to the long-wavelength limit. We compare the elastic constants we measure to those from Brillouin scattering experiments and to values reported for pure PbTiO3. We show that while the values of C44 are quite similar, those for C11 and C12 are significantly less in PMN and result in a softening of (C11-C12) over PbTiO3. The elastic constants also show an increased elastic anisotropy [2C44/(C11-C12)] in PMN versus that in PbTiO3. These results are suggestive of an instability to TA2 acoustic fluctuations in PMN and other relaxor ferroelectrics. We discuss our results in the context of the current debate over the “waterfall” effect and show that they are inconsistent with acoustic-optic phonon coupling or other models that invoke the presence of a second, low-energy optic mode.

  2. An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis.

    PubMed

    Zirbesegger, Kevin; Buccino, Pablo; Kreimerman, Ingrid; Engler, Henry; Porcal, Williams; Savio, Eduardo

    2017-01-01

    The synthesis of [ 11 C]L-deprenyl-D 2 for imaging of astrocytosis with positron emission tomography (PET) in neurodegenerative diseases has been previously reported. [ 11 C]L-deprenyl-D 2 radiosynthesis requires a precursor, L-nordeprenyl-D 2 , which has been previously synthesized from L-amphetamine as starting material with low overall yields. Here, we present an efficient synthesis of L-nordeprenyl-D 2 organic precursor as free base and automated radiosynthesis of [ 11 C]L-deprenyl-D 2 for PET imaging of astrocytosis. The L-nordeprenyl-D 2 precursor was synthesized from the easily commercial available and cheap reagent L-phenylalanine in five steps. Next, N -alkylation of L-nordeprenyl-D 2 free base with [ 11 C]MeOTf was optimized using the automated commercial platform GE TRACERlab® FX C Pro. A simple and efficient synthesis of L-nordeprenyl-D 2 precursor of [ 11 C]L-deprenyl-D 2 as free base has been developed in five synthetic steps with an overall yield of 33%. The precursor as free base has been stable for 9 months stored at low temperature (-20 °C). The labelled product was obtained with 44 ± 13% ( n  = 12) (end of synthesis, decay corrected) radiochemical yield from [ 11 C]MeI after 35 min synthesis time. The radiochemical purity was over 99% in all cases and specific activity was (170 ± 116) GBq/μmol. A high-yield synthesis of [ 11 C]L-deprenyl-D 2 has been achieved with high purity and specific activity. L-nordeprenyl-D 2 precursor as free amine was applicable for automated production in a commercial synthesis module for preclinical and clinical application.

  3. Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera.

    PubMed

    Koide, Ayako; Kataoka, Jun; Masuda, Takamitsu; Mochizuki, Saku; Taya, Takanori; Sueoka, Koki; Tagawa, Leo; Fujieda, Kazuya; Maruhashi, Takuya; Kurihara, Takuya; Inaniwa, Taku

    2018-05-25

    Imaging of nuclear gamma-ray lines in the 1-10 MeV range is far from being established in both medical and physical applications. In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12 C* or 11 B* and are considered good indicators of dose delivery and/or range verification. Further, in gamma-ray astronomy, 4.4 MeV gamma rays are produced by cosmic ray interactions in the interstellar medium, and can thus be used to probe nucleothynthesis in the universe. In this paper, we present a high-precision image of 4.4 MeV gamma rays taken by newly developed 3-D position sensitive Compton camera (3D-PSCC). To mimic the situation in proton therapy, we first irradiated water, PMMA and Ca(OH)2 with a 70 MeV proton beam, then we identified various nuclear lines with the HPGe detector. The 4.4 MeV gamma rays constitute a broad peak, including single and double escape peaks. Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile in the cross section of 12 C(p,p) 12 C*.

  4. Strains Responsible for Invasive Meningococcal Disease in Patients With Terminal Complement Pathway Deficiencies.

    PubMed

    Rosain, Jérémie; Hong, Eva; Fieschi, Claire; Martins, Paula Vieira; El Sissy, Carine; Deghmane, Ala-Eddine; Ouachée, Marie; Thomas, Caroline; Launay, David; de Pontual, Loïc; Suarez, Felipe; Moshous, Despina; Picard, Capucine; Taha, Muhamed-Kheir; Frémeaux-Bacchi, Véronique

    2017-04-15

    Patients with terminal complement pathway deficiency (TPD) are susceptible to recurrent invasive meningococcal disease (IMD). Neisseria meningitidis (Nm) strains infecting these patients are poorly documented in the literature. We identified patients with TPD and available Nm strains isolated during IMD. We investigated the genetic basis of the different TPDs and the characteristics of the Nm strains. We included 56 patients with C5 (n = 8), C6 (n = 20), C7 (n = 18), C8 (n = 9), or C9 (n = 1) deficiency. Genetic study was performed in 47 patients and 30 pathogenic variants were identified in the genes coding for C5 (n = 4), C6 (n = 5), C7 (n = 12), C8 (n = 7), and C9 (n = 2). We characterized 61 Nm strains responsible for IMD in the 56 patients with TPD. The most frequent strains belonged to groups Y (n = 27 [44%]), B (n = 18 [30%]), and W (n = 8 [13%]). Hyperinvasive clonal complexes (CC11, CC32, CC41/44, and CC269) were responsible for 21% of IMD cases. The CC23 predominates and represented 26% of all invasive isolates. Eleven of the 15 clonal complexes identified fit to 12 different clonal complexes belonging to carriage strains. Unusual meningococcal strains with low level of virulence similar to carriage strains are most frequently responsible for IMD in patients with TPD. © The Author 217. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  5. Stress History Simulation. Volume 2. A User’s Manual for a Computer Program to Modify Stress History Simulations

    DTIC Science & Technology

    1977-03-01

    4444444.000000I00071 7 Z 7 7 > > > > 𔄁 > > 27 Z 2 *.JUJUJ30T. 4444.4 .4.4 .4 .4 . . . . .4 . . Utiulti iLK) LMUJL) it)LJit)Li it)Lit)LULNJt)Lit .31)0 MiLK ...M4-cUro r4-4-t m4~qoIN 0--r..44-m.O40iinn’O4-in.0C’JNO.4tDMCU~r-- (uor-r-04-* V44 1 \\J.-4’ 1 C’) -PM.-4. .- 4 11-4 W4 I4 .4-* fl44C .tl. I4 MUCU 3 I

  6. Manning Implications of Logistics Support for Airland Battle.

    DTIC Science & Technology

    1985-10-01

    P4 0. C -0 a 0 0’ (v -4 0 0 4) co- u 4.440) 4.-4 44 0 01 CO C 0 0 - ’. 41 =- ~ ’ 0 0C $4 -4 j 1 04 $4 N, 01 0 140 WC-- co Cu~ W~a 41001E0 F3 1404-C...a -4 11 -4 F3 05--. S- a 14 043 1.a v-- 40 - 0 w 0 v-ŔUe cu 0> 0a0 54- 4-3t C v- w--v - U) z ED . U)-H 0 W 04 r. 4 ( 0) 4. r.-.00 C w 44 ca 4U)4- 4...2 4)W W w 4) co F3 r_ r. 4 ’-S r2 ((a. W04.C W-S 0 v 0 0 41 m 02’S" 44 4 Q4 -W04) -4 ’-4 44H - 0-4.4400 0 ( 00 Ad02 1 14 .024w.4t. A4’ >140- -- 02 4C

  7. Crystal structures of five 1-alkyl-4-aryl-1,2,4-triazol-1-ium halide salts.

    PubMed

    Guino-O, Marites A; Talbot, Meghan O; Slitts, Michael M; Pham, Theresa N; Audi, Maya C; Janzen, Daron E

    2015-06-01

    The asymmetric units for the salts 4-(4-fluoro-phen-yl)-1-isopropyl-1,2,4-triazol-1-ium iodide, C11H13FN3 (+)·I(-), (1), 1-isopropyl-4-(4-methyl-phen-yl)-1,2,4-triazol-1-ium iodide, C12H16N3 (+)·I(-), (2), 1-isopropyl-4-phenyl-1,2,4-triazol-1-ium iodide, C11H14N3 (+)·I(-), (3), and 1-methyl-4-phenyl-1,2,4-triazol-1-ium iodide, C9H10N3 (+)·I(-), (4), contain one cation and one iodide ion, whereas in 1-benzyl-4-phenyl-1,2,4-triazol-1-ium bromide monohydrate, C15H14N3 (+)·Br(-)·H2O, (5), there is an additional single water mol-ecule. There is a predominant C-H⋯X(halide) inter-action for all salts, resulting in a two-dimensional extended sheet network between the triazolium cation and the halide ions. For salts with para-substitution on the aryl ring, there is an additional π-anion inter-action between a triazolium carbon and iodide displayed by the layers. For salts without the para-substitution on the aryl ring, the π-π inter-actions are between the triazolium and aryl rings. The melting points of these salts agree with the predicted substituent inductive effects.

  8. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Key Largo Florida - Dixon Illinois)

    DTIC Science & Technology

    1993-01-01

    34(D.( .- I19 - I < o .i 11 1(0 a0 1~f 40 1 00 1 00 4111 -- I-ý I HH I- -’.t Il-03Ie HIt 1 ɘ -4 to C0 (0 N! -I 0 ~ A 11 AIIUII og >0Il0No 01 N (0...1 . 1, 10 0(0 If < 1-1 < <- ɜ < tI MO"( Fig 0 H H 0 1-H H H oil IMON0 ii z 0 0 0) 0 H 00 )- 0 000 .xit I 10 04 110 H- H U0) H’ z HH H- H C>H- IX...0r - - Tt-C 4 <t 4 1 4 4 44 4 4 -4 4 44 4 4 4 444 ( - -V)MZ-1Mr- nC)M tC J C14 4444In 4--Z.O00 it 1 41 ON I t 1 ( jb (C O ) 0) 1 0r 1 t C -1C N0000-404

  9. Investigation of a Multifrequency Reconfigurable Phased Array Antenna

    DTIC Science & Technology

    1991-05-01

    236 2.04 37.5 194 487 1639 22 05 2.ř 4A 2.37 I4.0 2.00 26.2 95 385 1.73 376 1497 23 -01 102 4.4 2.41 131 2.12 25.7 1.97 380 17 37.3 1497 24 0.1 313 46...CONTROL VOLTAGE - --- -30 I8 3I i 2 1 4 4 to I 10 At FREQUENCY C o 9Gift Figure 3-8. MMIC Specification 3-9 Report 6693 0 , coc D0C U, m wC, fc N 14 N...I I I -f 1-:t- 14 tj I IV t-r: It tU t- -11 H ill Afff Mill I I- -all tjLu 4A ff-- _mf 41 Mil Aill &U I 11i 7 > I till r4t I 11-11 It fl-lH f

  10. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg..., 43 Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8...

  11. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg..., 43 Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8...

  12. National Dam Safety Program. Welch Lake Dam (MO 10733), Missouri - Kansas City Basin, Boone County, Missouri. Phase I Inspection Report.

    DTIC Science & Technology

    1981-03-01

    Operating Facilities 10 4.4 Description of Any Warning System in Effect 10 4.5 Evaluation 10 SECTION 5 - HIDRAULIC /HYDROLOGIC 5.1 Evaluation of Features 11...Hm + 1/4L Y) A = 1/2 T (2d -A Y)c Q = (A 3 g/T) 0 .5 where: d = critical depth (feet) H c = available specific energy which is taken to be the heightm

  13. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg... Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8 Fresno 7, 30...

  14. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg... Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8 Fresno 7, 30...

  15. Lattice Mechanical Properties of Noble and Transition Metals

    NASA Astrophysics Data System (ADS)

    Baria, J. K.

    2004-04-01

    A model pseudopotential depending on an effective core radius but otherwise parameter free is used to study the interatomic interactions, phonon dispersion curves (in q and r-space analysis), phonon density of states, mode Grüneisen parameters, dynamical elastic constants ( C 11, C 12 and C 44), bulk modulus ( B), shear modulus ( C'), deviation from Cauchy relation ( C 12 C 44), Poisson’s ratio ( σ), Young’s modulus ( Y), behavior of phonon frequencies in the elastic limit independent of the direction ( Y 1), limiting value in the [110] direction ( Y 2), degree of elastic anisotropy ( A), maximum frequency ω max, mean frequency < ω>, < ω 2>1/2=(< ω>/< ω -1>)1/2, fundamental frequency < ω 2>, and propagation velocities of the elastic constants in Cu, Ag, Au, Ni, Pd, and Pt. The contribution of s-like electrons is calculated in the second-order perturbation theory for the model potential while that of d-like electrons is taken into account by introducing repulsive short-range Born-Mayer like term. Very recently proposed screening function due to Sarkar et al. has been used to obtain the screened form factor. The theoretical results are compared with experimental findings wherever possible. A good agreement between theoretical investigations and experimental findings has proved the ability of our model potential for predicting a large number of physical properties of transition metals.

  16. Tyndall AFB, Florida. Revised Uniform Summary of Surface Weather Observations. Parts A-F.

    DTIC Science & Technology

    1987-07-24

    OF RECORD: 71 -86 MONTHz DEC RAIN FRZIHN SNOW t OS SMOKE DUST % 08S HOURS I TSTMS LIOR RAIN cIOR MAIL WITH FOG C/OR BLOWING L/OR W/0BST TOTAL ILSTI I...1 133S1 5.71 23.60 .00 OCT 71 .b i 8.21 1.3 1 2.51 1.41 2.81 Z.51 ?.4 1 2.3 1 .7 1 -1 1 1 I 16.0 1 13871 3.12 16.11 .0c NOV 66.2 1 6.31 1.1 1 6.31...ae 2.C9 .76 1.66 Y.7- 1.6! *3.79 4.33 1.61 2.10 $4.33 b5 I .67 1.S!5 Z. 71 2.51; TRACE 4.4b 2.--- 2.bS 2.62 3.341 .95 2.14 4.46 66 1 1.32 Z.42 ’.’L

  17. The Clinical Impact of c-MET Over-Expression in Advanced Biliary Tract Cancer (BTC).

    PubMed

    Heo, Mi Hwa; Kim, Hee Kyung; Lee, Hansang; Kim, Kyoung-Mee; Lee, Jeeyun; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Park, Young Suk; Kim, Seung Tae

    2017-01-01

    Background : c-MET is a proto-oncogene that encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF). Activation of HGF-c-MET signaling involves cell invasiveness and evokes metastasis through direct involvement of tumor angiogenesis. However, the value of c-MET overexpression is still unknown in metastatic biliary tract cancer (BTC). Methods : We analyzed the incidence and clinicopathologic characteristics of c-MET overexpression in advanced BTC. Moreover, we investigated the value of c-MET overexpression in predicting response to gemicitabine plus cisplatin (GC), a first line standard regimen, and as a prognostic marker in metastatic BTC. Results : The BTC subtype distribution (N=44) was as follows: intrahepatic cholangiocarcinoma (IHCC, n=7), extrahepatic cholangiocarcinoma (EHCC, n=25) and gallbladder cancer (GBC, n=12). Liver (52.3%) was the predominant metastatic site, followed by lymph nodes (36.4%) and bone (15.9%). Among the 44 patients analyzed for c-MET expression, 15 (34.1%) exhibited c-MET overexpression in tumor tissues. There was no significant difference in the prevalence of c-MET overexpression among primary sites in EHCC (7/25, 28.0%), IHCC (3/7, 42.9%), and GBC (5/12, 41.7%). There was also no significant correlation between specific clinicopathologic variables and c-MET expression. Comparing the tumor-response to GC according to c-MET expression (overexpression vs. non-overexpression), there was no significant difference in either RR or DCR (p=0.394 and p >0.999, respectively). The median PFS for all 44 patients was 9.00 months (95% CI, 7.5-10.5 months) and there was no significant difference for PFS between patients with c-MET overexpression and those without (p=0.917). The median OS was 14.4 months (95% CI, 11.9-16.9 months). There was no significant difference in OS between patients with c-MET overexpression compared to those without (13.7 vs. 14.4 months, respectively; p=0.708). Conclusions : c-MET overexpression was detected in 34.1% of advanced BTC patients irrespective of tumor location. c-MET overexpression did not predict response to GC or survival. Further studies are needed to fully elucidate the value of c-MET overexpression as a novel biomarker in these patients.

  18. All Prime Contract Awards by State or Country, Place, and Contractor. Part 22 (Aua Amer-Honduras)

    DTIC Science & Technology

    1990-01-01

    5 01 񓡞i 0 La 4. U.444.4 4c 4c 41* UWl dc 4c...4C C. 0 d IL ~a.4 MW 1-1 U be 0 a 00003 0 mU 0 * a I 10.4 CD LL 00 Go G00 40 0000 1-1 qW In 0 40 t&. - 5 -4 -i..t- maoooonon 04.)m -im’ 000o >.a 0 . CV...00 t 2 Q0000000 OaN xa i004 aNO4 5 -1- J-JIJ-J 00 0 00f 0.4c 000000 0 1010CL a41 d-# 1 300000 22 1 00 wa 00000000 02 -9 a 3 4") a~ A -4-4 .4 -4-4 a 0

  19. Potent L-lactic acid assimilation of the fermentative and heterothallic haploid yeast Saccharomyces cerevisiae NAM34-4C.

    PubMed

    Tomitaka, Masataka; Taguchi, Hisataka; Matsuoka, Masayoshi; Morimura, Shigeru; Kida, Kenji; Akamatsu, Takashi

    2014-01-01

    We screened an industrial thermotolerant Saccharomyces cerevisiae strain, KF7, as a potent lactic-acid-assimilating yeast. Heterothallic haploid strains KF7-5C and KF7-4B were obtained from the tetrads of the homothallic yeast strain KF7. The inefficient sporulation and poor spore viability of the haploid strains were improved by two strategies. The first strategy was as follows: (i) the KF7-5C was crossed with the laboratory strain SH6710; (ii) the progenies were backcrossed with KF7-5C three times; and (iii) the progenies were inbred three times to maintain a genetic background close to that of KF7. The NAM12 diploid between the cross of the resultant two strains, NAM11-9C and NAM11-13A, showed efficient sporulation and exhibited excellent growth in YPD medium (pH 3.5) at 35°C with 1.4-h generation time, indicating thermotolerance and acid tolerance. The second strategy was successive intrastrain crosses. The resultant two strains, KFG4-6B and KFG4-4B, showed excellent mating capacity. A spontaneous mutant of KFG4-6B, KFG4-6BD, showed a high growth rate with a generation time of 1.1 h in YPD medium (pH 3.0) at 35°C. The KFG4-6BD strain produced ascospores, which were crossed with NAM11-2C and its progeny to produce tetrads. These tetrads were crossed with KFG4-4B to produce NAM26-14A and NAM26-15A. The latter strain had a generation time of 1.6 h at 35°C in pH 2.5, thus exhibiting further thermotolerance and acid tolerance. A progeny from a cross of NAM26-14A and NAM26-15A yielded the strain NAM34-4C, which showed potent lactic acid assimilation and high transformation efficiency, better than those of a standard laboratory strain. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  20. 11 CFR 100.11 - State (2 U.S.C. 431(12)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false State (2 U.S.C. 431(12)). 100.11 Section 100.11 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.11 State (2 U.S.C. 431(12)). State means each State of the United States, the District of...

  1. Elasticity, shear-mode softening and high-pressure polymorphism of wüstite (Fe1-xO)

    NASA Astrophysics Data System (ADS)

    Jackson, Ian; Khanna, S. K.; Revcolevschi, A.; Berthon, J.

    1990-12-01

    Elastic wave travel times have been determined as functions of hydrostatic pressure to 3 GPa for five modes of propagation in synthetic single-crystal wüstite Feo.943O by ultrasonic phase comparison. The measured travel times, corrected for transducer-bond phase shifts, constrain very accurately the zero-pressure elastic moduli (GPa) and, for the first time, their first pressure derivatives (dimensionless) as follows: C11∶218.4, dC11/dP∶9.65, C12∶123.0, dC12/dP∶2.77, C44∶45.5, dC44/dP∶-1.03. The zero-pressure moduli are in good agreement with the results of previous determinations by ultrasonic wave propagation but not with all of the moduli determined by resonance techniques. The variation of bulk modulus with pressure calculated from the Cij (P) is extrapolated to much higher pressures via third-order Eulerian isotherms and isentropes based on K0S = 154.9 GPa and (dKs/dP)0T = 4.90. The resulting isothermal and shock compression curves satisfactorily reproduce the experimental data to ˜70 GPa, thereby providing a unified description of essentially all data bearing on the compressibility of wüstite. At higher pressures, published shock compression studies provide clear evidence for the existence of a different phase of much greater density and incompressibility. Metallic values of electrical conductivity have been reported for pressures >70 GPa under conditions of shock and high-temperature static loading. Polyhedral face-sharing in either the B8(NiAs) or B2(CsCl) (or derivative) structures would result in shorter Fe-Fe distances, allowing greater 3d orbital overlap conducive to metallic conductivity. However, none of these possibilities satisfactorily accounts for the large inferred increase (14-20%) in zero-pressure density unless the Fe-O distance is also reduced by 3-5% by electron delocalization or spin-pairing. The marked violation of the Cauchy condition associated with the very low value of C44 and its unusual temperature and pressure derivatives are attributable mainly to exchange coupling between nearest and next-nearest neighbor spins.

  2. Analyzing the anisotropic Hooke's law for children's cortical bone.

    PubMed

    Lefèvre, Emmanuelle; Lasaygues, Philippe; Baron, Cécile; Payan, Cédric; Launay, Franck; Follet, Hélène; Pithioux, Martine

    2015-09-01

    Child cortical bone tissue is rarely studied because of the difficulty of obtaining samples. Yet the preparation and ultrasonic characterization of the small samples available, while challenging, is one of the most promising ways of obtaining information on the mechanical behavior of non-pathological children׳s bone. We investigated children׳s cortical bone obtained from chirurgical waste. 22 fibula or femur samples from 21 children (1-18 years old, mean age: 9.7±5.8 years old) were compared to 16 fibula samples from 16 elderly patients (50-95 years old, mean age: 76.2±13.5 years old). Stiffness coefficients were evaluated via an ultrasonic method and anisotropy ratios were calculated as the ratio of C33/C11, C33/C22 and C11/C22. Stiffness coefficients were highly correlated with age in children (R>0.56, p<0.01). No significant difference was found between C11 and C22 for either adult or child bone (p>0.5), nor between C44 and C55 (p>0.5). We observe a transverse isotropy with C33>C22=C11>C44C55>C66. For both groups, we found no correlation between age and anisotropy ratios. This study offers the first complete analysis of stiffness coefficients in the three orthogonal bone axes in children, giving some indication of how bone anisotropy is related to age. Future perspectives include studying the effect of the structure and composition of bone on its mechanical behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. 47 CFR 15.233 - Operation within the bands 43.71-44.49 MHz, 46.60-46.98 MHz, 48.75-49.51 MHz and 49.66-50.0 MHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....100 8 44.160 49.160 9 44.180 49.200 10 44.200 49.240 11 44.320 49.280 12 44.360 49.360 13 44.400 49.400 14 44.460 49.460 15 44.480 49.500 16 46.610 49.670 17 46.630 49.845 18 46.670 49.860 19 46.710 49....970 (c) The field strength of the fundamental emission shall not exceed 10,000 microvolts/meter at 3...

  4. Implication of LRRC4C and DPP6 in neurodevelopmental disorders

    PubMed Central

    Maussion, Gilles; Cruceanu, Cristiana; Rosenfeld, Jill A.; Bell, Scott C.; Jollant, Fabrice; Szatkiewicz, Jin; Collins, Ryan L.; Hanscom, Carrie; Kolobova, Ilaria; de Champfleur, Nicolas Menjot; Blumenthal, Ian; Chiang, Colby; Ota, Vanessa; Hultman, Christina; O’Dushlaine, Colm; McCarroll, Steve; Alda, Martin; Jacquemont, Sebastien; Ordulu, Zehra; Marshall, Christian R.; Carter, Melissa T.; Shaffer, Lisa G.; Sklar, Pamela; Girirajan, Santhosh; Morton, Cynthia C.; Gusella, James F.; Turecki, Gustavo; Stavropoulos, D. J.; Sullivan, Patrick F.; Scherer, Stephen W.; Talkowski, Michael E.; Ernst, Carl

    2018-01-01

    We performed whole-genome sequencing on an individual from a family with variable psychiatric phenotypes that had a sensory processing disorder, apraxia, and autism. The proband harbored a maternally inherited balanced translocation (46,XY,t(11;14)(p12;p12)mat) that disrupted LRRC4C, a member of the highly specialized netrin G family of axon guidance molecules. The proband also inherited a paternally derived chromosomal inversion that disrupted DPP6, a potassium channel interacting protein. Copy Number (CN) analysis in 14,077 cases with neurodevelopmental disorders and 8,960 control subjects revealed that 60% of cases with exonic deletions in LRRC4C had a second clinically recognizable syndrome associated with variable clinical phenotypes, including 16p11.2, 1q44, and 2q33.1 CN syndromes, suggesting LRRC4C deletion variants may be modifiers of neurodevelopmental disorders. In vitro, functional assessments modeling patient deletions in LRRC4C suggest a negative regulatory role of these exons found in the untranslated region of LRRC4C, which has a single, terminal coding exon. These data suggest that the proband’s autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders. PMID:27759917

  5. Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10214 U.S. Navy Ada/M, Version 2.0 (/OPTIMIZE Option) VAX 8550 and VAX 11/785 Hosts AN/UYK-44 Target

    DTIC Science & Technology

    1989-12-01

    s -M-COM ST-1815A, Ada Joint Program Office 17.gbJftYCLSSF~ATW4 Is. SECURITY CLASSFAT04 OAS. TRUmVACAT M. LUITAf WCOF ABSTRACT Xi LLASSIFIED I CM ...Department of Defense Dist Specla Washington DC 20301 AVF Control Number: NIST89USN5556_1. 10 DATE VSR CPIEM BEFORE ON-SITE: 08-11-89 DATE VSR C34PLETED AFTER...ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO C31ME : 12-29-89 DATE VSR MODIFIED PER AVO CMtEN: 04-27-90 Ada O4PIIER VALIDATION SUM4M REPORT

  6. Comets C/2003 X5-X11 and Y2-Y10 (SOHO)

    NASA Astrophysics Data System (ADS)

    Battams, K.; Boschat, M.; Zhou, X.-M.; Hoffman, T.; Leprette, X.; Matson, R.; Kracht, R.; Sachs, J.; Marsden, B. G.; Kisala, R.

    2004-06-01

    Further to IAUC 8356, K. Battams reports measurements for additional Kreutz sungrazing comets found on SOHO website C2 images by M. Boschat (C/2003 X5, X7, Y5, Y8), X.-m. Zhou (C/2003 X6, X9, X11), T. Hoffman (C/2003 X8), X. Leprette (C/2003 X10, Y2), R. Matson (2003 Y3, Y9, Y10), R. Kracht (C/2003 Y4, Y7), and J. Sachs (C/2003 Y6). C/2003 Y6 and Y7 were also visible on C3 images. The reductions by B. G. Marsden (and by R. Kisala for C/2003 Y8, Y9, Y10) and orbital elements by Marsden appear on the MPECs cited below. Comet 2003 UT R.A. (2000) Decl. MPEC C/2003 X5 Dec. 4.896 16 46.9 -24 12 2004-L24 C/2003 X6 6.396 16 52.2 -24 20 2004-L24 C/2003 X7 7.829 16 58.6 -24 27 2004-L24 C/2003 X8 8.246 17 00.9 -24 31 2004-L24 C/2003 X9 8.621 17 02.2 -24 34 2004-L24 C/2003 X10 11.188 17 14.5 -24 41 2004-L25 C/2003 X11 13.588 17 25.7 -24 57 2004-L25 C/2003 Y2 19.621 17 53.6 -25 08 2004-L25 C/2003 Y3 19.979 17 55.0 -25 02 2004-L25 C/2003 Y4 20.729 17 58.8 -25 14 2004-L25 C/2003 Y5 22.771 18 08.5 -25 08 2004-L25 C/2003 Y6 23.571 18 14.3 -27 22 2004-L26 C/2003 Y7 24.638 18 20.0 -27 44 2004-L26 C/2003 Y8 25.288 18 19.6 -25 00 2004-L67 C/2003 Y9 25.479 18 20.7 -24 46 2004-L67 C/2003 Y10 26.064 18 23.5 -24 50 2004-L67

  7. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 7. (Fahey Watts Architects-General Contract and Sales)

    DTIC Science & Technology

    1989-01-01

    0 -m Il 5 ))40 . I: 0 40-4-4 -x000) of I 00-4qN< 66 ."eN *-4NI g - *N .40)-4 .4 U1.4 MOMO t00 m m’ C-eq an .- 4-4 eqI 0 .-44 1 ::-4...991 M (0N lice x W (A 4 4C (5n ( U) n44 1-44e mlt w. < Z 91 (0N eq4 c 0 a >- 0 0u >- >- 00X 1- 0 1-0o 1- cc I-- 0 0 C I M C14 91 -4 W. cc . 5 0D 0 -. 1 .1...001 - 00 IO 0 ( NC1n1- 1-1 C90 1 M 4 I 9(no0 1-- 0 4C 0 . 4 4 ~i 0 - 5 <C 4 ZNNZ 0 91 0 j

  8. All Prime Contract Awards by State or Country, Place, and Contractor. Part 3 (Lomita, California-Sand Hill, California).

    DTIC Science & Technology

    1990-01-01

    I 000 MI ~CY) CCCC1)c ) C11 IP )ClOCOCO MC = 1) CO) ~ CYO ~ C’) ~CO =1 ) v C1 = (1 11 1(00 COO f rH -r -I ,r -I * 1 ’ -- - r- 4- r- 4- r- 4- 4- 4- 4...4 < M Cf) 11 0 0-40 0 1-1-40 -400 >-400COO4000 Uo -40 r 11 103M 11 0 t-400 zo 0)0 >-MOO -Moooooooo a 0)o < 11 1 MCI) 11 (71 1-- a* 0) _j 00) >. CIO

  9. 78 FR 11948 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... Criteria 733 railroads...... 50 examinations.... 1 hour 50 for DSLEs--Exams. (c) Written Reports/ 10... 104-13, Sec. 2, 109 Stat. 163 (1995) (codified as revised at 44 U.S.C. 3501-3520), and its.... 44 U.S.C. 3506(c)(2)(A); 5 CFR 1320.8(d)(1), 1320.10(e)(1), 1320.12(a). Specifically, FRA invites...

  10. An Evaluation of an Automatic Cell Detection and Tracking Algorithm.

    DTIC Science & Technology

    1982-11-03

    OUTPUT CENTRCIC 2 N 5 fR %F4 Q 11 Ct, VE L CC. ’ SER Ar MM X R CZL L 2 TRA A1M RNG AV PK V x L A KC IC AV CELL MSK# "T I[ IC AOT. DIV . uL NC OEC K DO8 CE...C go Km EC EP/ ISK.4/ K ,C tC 0 Sk 1 CS 333 164 4? 44 I CoC C.C c 1 2C.2 1. 1.1 ; 5 C C C.CC C.-C C, Yft HMM AREA *FLUX NEAR NEIGMEQR ACT kC NC...InIt Iof It e ru. , ng p I sihbt areas of ailgorjithi breaikdoari. A~n aver-aIe 5V~ ’f the I"u. 11 teo ’ b% 1try toe A Il are tAi(ti ’iti ar)tiet

  11. Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Acton (Sta), Mass.-Wayne County, Missouri). Part 7

    DTIC Science & Technology

    1994-03-01

    ED00LEI00ED00 0D 00C ( o DE O 1 c’m mmlmmm am mm~ mII MeO ds~)(4 - -4,.4-I4 .-4 ’ 4 -4 -4 4 No v0 to M (V) 110 1 0 4’) If I (i9tot i 0 (20) D(1...ooIm~0o Uom4-( el.W it I W00 II’a4- 00 W4al 000 0al0al)04fal -n U )-4 as W IfI cacao IIZN.-4 V-4 &A-4 v -4 to CO-E..4-4 " .*-E4 4 -4 -4U1r -44-v .4 -40...n E 44V4.*4 x Cn 11 cacao MI mn -4.E W CON Off 0 00050 If >- 11 01 cooG it -4 _a LLa 11 c 1 0000 1 N4cr 11 100 0 W 1 11 1 E for 10 -4- -4 -.4 -4- ý4

  12. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 4 (Cameo Farm, Washington, DC - Comspec Corp, Salt Lake City, Utah), FY1991

    DTIC Science & Technology

    1991-01-01

    4 U) a I M-4 0 Of--I- -41-- (000 41- -4 r 00L." L A- ~ 000 LL 0.U oo L (0 W to 1-41W I M-1 10000 00 XC4 0.0 -4.4 (a xldcl x l xx x wx mem .IU -4 o 0...00000000000003- 4 3 -.1 -800 . 0 ICO v na m o o e o c c o c c o c c c z 0 OCa-a- o z mEm -4 NZ z w cI 0 himC30-4~L < i 4 44K u to 6I - Z0000000...nW-t 0 NN% "C1,1 MXO < < Z Z IS- 1CIA N SWOOOOD-0-411111100--00000000044 W3(0U W OHP C IO Ml - 0 0 0 0 0 0 0 0 00 0 0 0 0 0 0 0 0 0 04 4)ൈ 1-1 HfE I

  13. Effect of mastitis on luteal function and pregnancy rates in buffaloes.

    PubMed

    Mansour, Mohamed Mohsen; Hendawy, Amin O; Zeitoun, Moustafa M

    2016-09-15

    The aim of this study was to investigate the effects of mastitis on CL development and function and pregnancy rate in buffaloes. Sixty-six buffaloes (Bubalus bubalus) reared in a commercial farm at El-Beheira governorate, north of Egypt were used in this study. According to the visual observation of milk, physical examination of the udder and actual somatic cell count in milk, buffalo cows were divided into three groups: without mastitis (W), n = 23; subclinical mastitis (SC), n = 18; and clinical mastitis (C), n = 25. All buffalo cows were synchronized by double dose of PGF2α (11-day interval) and inseminated by frozen-thawed semen of fertile bull. Mean CL diameter was ultrasonically examined on Days 5, 9, 12, 16, 21, and 25 after artificial insemination (AI). Blood samples were taken on the days of ultrasonography for progesterone (P4) assay. Results indicated that pregnancy rates were lower (P < 0.05) in C (28.00%) and SC (55.56%) compared with W (69.57%) on Day 25 after first AI. Pregnancy rates reduced to 60.87%, 44.45%, and 16.00% in W, SC, and C, respectively, at Day 45 after insemination. Thus, the embryonic loss was 8.7%, 11.11%, and 12.00 % in W, SC, and C cows, respectively. Pregnancy rates decreased between 44.32% and 50.51% when mastitis occurred during Day -15 before to Day +30 after AI, compared with 59.22% in the uninfected cows. The diameter of CL was greater (P < 0.05) in W than SC and C cows starting at Day 9 postbreeding onward. Likewise, P4 concentrations on Days 9 through 25 after AI were greater (P < 0.05) in W cows as compared to SC and C cows. Positive correlations (P < 0.01) were found on Days 5, 9, 12, 16, 21, and 25 after AI between CL diameter and P4 concentrations. Similar trend was found among CL diameter, P4 concentrations, and pregnancy rate. Accordingly, incidence of mastitis revealed suppression to both CL diameter and function leading to significant reduction in pregnancy outcome of buffalo cows. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. All Prime Contract Awards by State or Country, Place, and Contractor. Part 17 (Abbeville S. Carolina-Eldorado Texas)

    DTIC Science & Technology

    1990-01-01

    zi-Zx a IN -4-4 1. *4-4-4-4 P~. NINI r- r- 4 0) -4 I- 11 ~w0.fp- a C 0 0 40 40000 0 000000 0 0 0 ON ofWI-4 II Z 2z Z 222 z zzzlcz2 z z z 0 .4- N 2...ISN < INN NN ɜ in 0C14 :: 0 ɜ 0 M NJ 4 N N 4I N I L0-4 C .) C , C ..0 0 0000 C0 000000 0 0 0 I U N- l ) N N NPJN N N N 44 8 0-4C40 P4 NN rN 04~0 88M c ...88, &N 0-4Ci C4 0N 00 04 0000 0 000 0 04 0 .0N C S 8 88 C Ŕ,8 4 (74 C4 0000N 4N 0000004" C44 If U C.N) N 0N J N N N N u8 8044 8 2 --- > --- >>> 𔃾

  15. Methylobacterium pseudosasae sp. nov., a pink-pigmented, facultatively methylotrophic bacterium isolated from the bamboo phyllosphere.

    PubMed

    Madhaiyan, Munusamy; Poonguzhali, Selvaraj

    2014-02-01

    A pink-pigmented, Gram negative, aerobic, facultatively methylotrophic bacterium, strain BL44(T), was isolated from bamboo leaves and identified as a member of the genus Methylobacterium. Phylogenetic analysis based on 16S rRNA gene sequences showed similarity values of 98.7-97.0 % with closely related type strains and showed highest similarity to Methylobacterium zatmanii DSM 5688(T) (98.7 %) and Methylobacterium thiocyanatum DSM 11490(T) (98.7 %). Methylotrophic metabolism in this strain was confirmed by PCR amplification and sequencing of the mxaF gene coding for the α-subunit of methanol dehydrogenase. Strain BL44(T) produced three known quorum sensing signal molecules with similar retention time to C8, C10 and C12-HSLs when characterized by GC-MS. The fatty acid profiles contained major amounts of C18:1 ω7c, iso-3OH C17:0 and summed feature 3 (C16:1 ω7c and/or iso-C15:0 2-OH), which supported the grouping of the isolate in the genus Methylobacterium. The DNA G+C content was 66.9 mol%. DNA relatedness of the strain BL44(T) to its most closely related strains ranged from 12-43.3 %. On the basis of the phenotypic, phylogenetic and DNA-DNA hybridization data, strain BL44(T) is assigned to a novel species of the genus Methylobacterium for which the name Methylobacterium pseudosasae sp. nov. is proposed (type strain BL44(T) = NBRC 105205(T) = ICMP 17622(T)).

  16. Defect-induced change of temperature-dependent elastic constants in BCC iron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gao, N.; Setyawan, W.; Zhang, S. H.

    2017-07-01

    The effects of radiation-induced defects (randomly distributed vacancies, voids, and interstitial dislocation loops) on temperature-dependent elastic constants, C11, C12, and C44 in BCC iron, are studied with molecular dynamics method. The elastic constants are found to decrease with increasing temperatures for all cases containing different defects. The presence of vacancies, voids, or interstitial loops further decreases the elastic constants. For a given number of point defects, the randomly distributed vacancies show the strongest effect compared to voids or interstitial loops. All these results are expected to provide useful information to combine with experimental results for further understanding of radiation damage.

  17. Rayleigh surface waves in ultraheavily doped n-Si

    NASA Astrophysics Data System (ADS)

    Sood, A. K.; Cardona, M.

    1986-11-01

    We report the effect of free carriers on the velocity of surface Rayleight waves (SRW) in n-type Si studied by Brillouin scattering. The samples prepared by ion implantation followed by laser annealing have carrier concentrations up to 3 x 10 21cm-3. The SRW velocity is observed to decrease significantly on doping (-18% for the heaviest doped sample). The large softening of the velocity can be quantitatively explained on the basis of the decrease of all the three independent elastic constants C 11, C 12, and C 44 in n-Si along with the changes in the density of the doped layer due to the dopant ions.

  18. The Single-Crystal Elasticity of Yttria (Y2O3) to High Temperature

    NASA Technical Reports Server (NTRS)

    Kriven, Waltraud M.; Palko, James W.; Sinogeikin, Stanislav V.; Bass, Jay D.; Sayir, Ali; Levine, Stanley R. (Technical Monitor)

    2000-01-01

    The single-crystal elastic moduli of yttria have been measured by Brillouin spectroscopy up to 1200 C. The room temperature values obtained are C11 = 223.6 +/- 0.6 GPa, C44 = 74.6 +/- 0.5 GPa, and C12 = 112.4 +/- 1.0 GPa. The resulting bulk and (Voigt-Reuss-Hill) shear moduli are K = 149.5 +/- 1.0 GPa and G(sub VRH) = 66.3 +/- 0.8 GPa, respectively. These agree much more closely with experimental values reported for polycrystalline samples than do previous single-crystal measurements. Linear least squares regressions to the variation of bulk and shear moduli with temperature result in derivatives of dK/dT = -17 +/- 2 MPa/degC and dG(sub VRH)/dT = -8 +/- 2 MPa/degC. Elastic anisotropy was found to remain essentially constant over the temperature range studied.

  19. Fire Management/Suppression Systems/Concepts Relating to Aircraft Cabin Fire Safety.

    DTIC Science & Technology

    1982-07-01

    polyamide- cm; cell size, cm; paper honeycomb; paper honeycomb; density, kg/cm 3 ; filler 2.413;0.31; 48.06; 2.413;0.31; 48.06; no core filler no core...0 4’ 14 ~ 1 4 44 N4 El4 (36M -11 - 0 0 N4 8A 0o N. 0 04 0n 0m C,0 0 44 . . 000040 -t 0 0 880 -8 ,0 04 0 C, 0 C4 4-0 OD -CD0C, m. g G - C4 A - 40 a

  20. Multilocus enzyme electrophoresis on agarose gel as an aid to the identification of entomopathogenic Bacillus sphaericus strains.

    PubMed

    Zahner, V; Rabinovitch, L; Cavados, C F; Momen, H

    1994-04-01

    Sixty strains of Bacillus sphaericus, including 31 insect pathogens were studied by multilocus enzyme electrophoresis and were classified into 44 zymovars (electrophoretic types). Among the entomopathogenic strains, 11 belong to the same zymovar (Z59) indicating a widespread frequent genotype. Bands of enzyme activity were not detected among the strains for the loci GPI (E.C.5.3.1.9), G6P (E.C.1.1.1.49), 6PG (E.C.1.1.1.44) and ME (E.C.1.1.1.40). The enzymatic loci NP (E.C.2.4.2.1) and ACON (E.C.4.2.1.3) were monomorphic while the other enzymes, MDH (E.C.1.1.1.37), LeDH (E.C.1.4.1.9), ADH (E.C.1.4.1.1), EST (E.C.3.1.1.1), PEP-2 (E.C.3.4.11.1), PEP-3 (E.C.3.4.11) and PEP-D (E.C. 3.4.13.9) were polymorphic. The genetic variation in the non-insect pathogenic group seemed to be greater than in the entomopathogenic group. This latter group appears to be distinct from other strains of these species. All insect pathogens were recovered in the same phenetic cluster and a diagnostic allele is reported for the identification of entomopathogenic strains.

  1. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 5 (Columbia Asphalt & Gravel Inc - Dela Tek Inc).

    DTIC Science & Technology

    1985-01-01

    40 40 4000 1 O- 4 00 000 0 C 40 40 ca c 1- Q 4- - In In In o - In 0 co l. 40 l N N 𔃺 C)3 0 0N In In IN N I N I 𔃺’ D coca In4 Of4 I 4 W 4 W 1 NWWI. 4...1( n r- PP, - P - - - )0 00 awl-I qt0( Coo 0- -I41-- <- M (0 " 00000000mm) C 00 000 om- -1-4I I.NOI1)1) W1 ’. * * (0 .17 0000 -CM 0.3 0C4C - Coala Ow... coca r-. 4.-U, M LA4( 44( 0I NY NN4 NNic N N ( C) N (0" M (0 04o -44 3 4( 4 44 44 4d -C 4 33 4 -4(0 K m( -4 43l CK00 0) 00 00 0 0 0 00 0 0U 0)co C I

  2. 4,4′-Bipyridine–pyroglutamic acid (1/2)

    PubMed Central

    Arman, Hadi D.; Kaulgud, Trupta; Tiekink, Edward R. T.

    2009-01-01

    In the title co-crystal, C10H8N2·2C5H7NO3, the 4,4′-bipyridine mol­ecule [dihedral angle between the pyridine rings = 36.33 (11)°] accepts O—H⋯N hydrogen bonds from the two pyroglutamic (pga) acid mol­ecules. The pga mol­ecules at each end of the trimeric aggregate self-associate via centrosymmetric eight-membered amide {⋯HNCO}2 synthons, so that the crystal structure comprises one-dimensional supra­molecular chains propagating in [13]. C—H⋯O and π–π stacking inter­actions [centroid–centroid separation = 3.590 (2) Å] consolidate the structure. PMID:21578523

  3. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 11 (Hilton Systems Inc -International Industries Inc)

    DTIC Science & Technology

    1990-01-01

    A11 10 m 4(1 CI (00 10 <D 0 1(0 (4 -1 -*It j-I -ti j 1 -114 -14 1N N r > KfC i i-I - of ’D I <( m it 4 44 LAO<< U)U IL- C LAO L𔃻 ~ I- Ai>> tor)> LNMMM...4 if Z InIn In in n toIn tr onIn In Z.10- 01 o( c > ) In In n InfLn InL In I n 20 C ZIn InfIn Z In 11. if-c I (0-4 11Ir nV no U1(1() on C )() 0 I a1

  4. Structure and elasticity of phlogopite under compression: Geophysical implications

    NASA Astrophysics Data System (ADS)

    Chheda, Tanvi D.; Mookherjee, Mainak; Mainprice, David; dos Santos, Antonio M.; Molaison, Jamie J.; Chantel, Julien; Manthilake, Geeth; Bassett, William A.

    2014-08-01

    We investigated the response of the crystal structure, lattice parameters, and unit-cell volume of hydrous layered silicate phlogopite at conditions relevant to subduction zone settings. We have used first principles simulation based on density functional theory to calculate the equation of state and full elastic constant tensor. Based on the generalized gradient approximation, the full single crystal elastic constant tensor with monoclinic symmetry shows significant anisotropy with the compressional elastic constants: c11 = 181 GPa, c22 = 185 GPa, c33 = 62 GPa, the shear elastic constants c44 = 14 GPa, c55 = 20 GPa, c66 = 68 Ga, and c46 = -6 GPa; the off diagonal elastic constants c12 = 48 GPa, c13 = 12 GPa, c23 = 12 GPa, c15 = -16 GPa, c25 = -5 GPa and c35 = -1 GPa at zero pressure. The elastic anisotropy of phlogopite is larger than most of the layered hydrous phases relevant in the subduction zone conditions. The shear anisotropy, AVS for phlogopite is ∼77% at zero pressure condition and although it decreases upon compression it remains relatively high compared to other hydrous phases relevant in the subduction zone settings. We also note that the shear elastic constants for phlogopite are relatively low. Phlogopite also has a high isotropic bulk VP/VS ratio ∼2.0. However, the VP/VS ratio also exhibits significant anisotropy with values as low as 1.49. Thus, phlogopite bearing metasomatized mantle could readily explain unusual VP/VS ratio as observed from seismological studies from the mantle wedge regions of the subduction zone.

  5. Elastic constants of random solid solutions by SQS and CPA approaches: the case of fcc Ti-Al.

    PubMed

    Tian, Li-Yun; Hu, Qing-Miao; Yang, Rui; Zhao, Jijun; Johansson, Börje; Vitos, Levente

    2015-08-12

    Special quasi-random structure (SQS) and coherent potential approximation (CPA) are techniques widely employed in the first-principles calculations of random alloys. Here we scrutinize these approaches by focusing on the local lattice distortion (LLD) and the crystal symmetry effects. We compare the elastic parameters obtained from SQS and CPA calculations, taking the random face-centered cubic (fcc) Ti(1-x)Al(x) (0 ≤ x ≤ 1) alloy as an example of systems with components showing different electronic structures and bonding characteristics. For the CPA and SQS calculations, we employ the Exact Muffin-Tin Orbitals (EMTO) method and the pseudopotential method as implemented in the Vienna Ab initio Simulation Package (VASP), respectively. We show that the predicted trends of the VASP-SQS and EMTO-CPA parameters against composition are in good agreement with each other. The energy associated with the LLD increases with x up to x = 0.625 ~ 0.750 and drops drastically thereafter. The influence of the LLD on the lattice constants and C12 elastic constant is negligible. C11 and C44 decrease after atomic relaxation for alloys with large LLD, however, the trends of C11 and C44 are not significantly affected. In general, the uncertainties in the elastic parameters associated with the symmetry lowering turn out to be superior to the differences between the two techniques including the effect of LLD.

  6. All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 12 (Allaire, New Jersey - White Sands Missile Range, New Mexico).

    DTIC Science & Technology

    1985-01-01

    444 (0(0(C0(0(0(0(co((0(0((0(0 00000000 0)00 V -r M( -4 -4-4-q-4-40 C’C’r m’C’C’ 4 44t-l 4 281 ) 0r U, a wa. 8(-43 000000 00000000000000 00000000 1-40...OOOOOOOOOOOOOOOOOOcOO In< 04W -4’w ZWi 00zz z zz zz z WOOOOOOOOOOOOOOOzzz WO O O O OO O O O O O 0 󈧅 1-44. 4- C N "I4-4’)C)U) Nw)m40w0m00-U)0)C’ -t Ln r, w "w

  7. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Bt North America Inc. - Classified Location Domestic)

    DTIC Science & Technology

    1994-03-01

    V4,(41, Or,.in cri nN c >1r- 0 10 f tao oinon0 40 M-4 -4 td n -w toce, of IC 𔃺 0 ca I1-&n UO0 - qtY(DC -04N I- . 30 C S-i Ur’L) . L-M4 U -4~ C...d 0o II Nca( 0 CI400W000 CD 10) Ny It 4. ev MNN.P.P rn If CIL I co00t I’l -4 co0 00000 -00 0 00C) 0 CV 4.4 Me V DCo tD H11 10 004D11 Nm Oin 000000...CO -4 0 11 -2c z .- Z 11 1 CO 0 fm 11 C z 2c z ed C z zx If I ca a 00 11 1- ed tv (d I td III 11 1 00000 11 00-t .- !`ý- W M It r- Ln Ln 0 tma N -4 -4

  8. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 11 (Lemmon Company, Sellersville Pennsylvania - McEwen Construction, Beale AFB, California), FY1991

    DTIC Science & Technology

    1991-01-01

    Mw N1 -.44 N 0000 0a a I IS -40 UA 00000000000- P- 1 0 WOO 0 -404 0N 0 U-4: 5 -4to U 0 C4N N N 0044044 .4 w4.4 .4 ..4-4 -4 ~ (’ C m C. U-4 W U-4N U1...ininO4Nsio 0 in0 0) ON4CS in 0000 4V In ( wo U 0 -44! in W 14 01V- -4-4.4 N00r -4 .4 -4.50 U 4 0OO 0 -4-4 NM in N4 U> O- :i00 U 1 %. 1 woo00 U .4 U...40O0 in wU1444 30 0o I0 U46- 1I cd 0 U )4444444 C in 000 0 L- 1 - 4o in 0000 er- int N 0I1 COCO U .A140NNNNNN min 000C -of- ’C00 0-4 m.C1-r1 win 04

  9. All Prime Contract Awards by State or Country, Place, and Contractor. Part 13 (Allendale, New Jersey -Otero, New Mexico)

    DTIC Science & Technology

    1990-01-01

    N R CA (A CAl (no L4 0 Ij)4Q # j)C U n<U U uM0 ii C-4 ɘ :: 0. H00 .- -Wt .- -()0 M L 1 L -0 nI n L 4( I M 1((0 11 44 4 44 4 44 4 4 z4 4 0) ISO ...0 > ə IMN C13 0t Z 0 044>>~ 0000c 1,41 1IM" Ŗ 1- ) I-- I-- I.- I- U4 Io 14- (I), isL)0z 00 I- ISO ION It -~W ) f z i IION N/ 0A 0 1. 2 0 on 01-- w 0...ZI o M cv ISO . CL ’) C) cn0 000 2>C) 1 0 0 -6 co C1 mI ii 2 W- 0) 0 1-4 0 0404 0 O DU)C> (c In < wi coC’ II La.) Z"I 00 I-I > w o .Joo40 C) loo oo w>0C

  10. Antenna coupling--a novel mechanism of radiofrequency electrosurgery complication: practical implications.

    PubMed

    Robinson, Thomas N; Barnes, Kelli S; Govekar, Henry R; Stiegmann, Greg V; Dunn, Christina L; McGreevy, Francis T

    2012-08-01

    (1) To determine if antenna coupling occurs in common operating room scenarios. (2) To define modifiable clinical variables that reduce the magnitude of antenna coupling. Mechanisms of electrosurgical burns where monitoring devices contact the surgical patient are unclear. Antenna coupling occurs when the "bovie" active electrode (electrically active transmitting antenna) emits energy, which is captured by a nonelectrically active wire (electrically inactive receiving antenna) in close proximity without direct contact. Monopolar radiofrequency energy was delivered to a laparoscopic instrument (electrically active transmitting antenna), whereas other nonelectrically active wires (electrically inactive receiving antenna) including electrocardiogram (EKG) lead, nonactive "bovie" pencil, and nerve electrode monitor were placed in proximity. Temperature changes of tissue placed adjacent to the electrically inactive receiving antennae were measured. Nonelectrically active wires (receiving antenna) increase tissue temperature when lying parallel to the active electrode cord: EKG pad 2.4°C ± 1.2°C (P = 0.002), "bovie" pencil tip 90°C ± 9°C (P < 0.001), and nerve electrode monitor 106°C ± 12°C (P < 0.001). Factors that reduced the heat generated by antenna coupling included the following: increasing angulation between transmitting and receiving antennae (parallel = 90°C ± 9°C; 45° angle = 53°C ± 10°C; perpendicular = 35°C ± 11°C; P < .001), increasing separation distance between parallel transmitting and receiving antenna (<1 cm = 90°C ± 9°C; 15 cm = 44°C ± 18°C; 30 cm = 39°C ± 2°C; P < .001); and decreasing generator power setting (15 W = 59°C ± 11°C; 30 W = 90°C ± 9°C; 45 W = 98°C ± 8°C; P < .001). Antenna coupling occurs in common operating room scenarios. Simple, practical measures by the surgeon, such as orienting the receiving antenna at a greater angle and with greater separation to the active electrode cord, or lowering the generator power setting reduce antenna coupling.

  11. Polymer/Solvent and Polymer/Polymer Interaction Studies

    DTIC Science & Technology

    1979-08-01

    sealed these solvents (still under nitrogen) in glass tubes. During the first distillation a dark residue remained in the boiler , but no such residue...rN ’ N ýd C’ d 0q 0- H H- H- -1 0j Ob) 0 04i O 󈧭Ji H, 0; C; 0! : H 41-4 4-4 E 4-1 CO H 1-1 ŕ C- C) -- 0p 0 p- v. i> mt %D m >fr 0 4-4 0𔃾-4> HHO

  12. Oceanographic Analyses and Forecasts for Fleet Support (Services and Codes). Revised.

    DTIC Science & Technology

    1967-08-01

    unit of thousands is omitted.) 11I SOUND VELOCITY PROFILE The SVP message form will normally follow the TD profile to which it pertains in the following...i ra 0 0 a 3’: VE C//3 000Q F- A E-4 =) 4-4 0.. 0- P4 C4 L) r. ~ N C)(D~ > a) CO C4 IHQ N E- .,1 0 r 4 4-4 V L 04 04 0 0 = rz - r- i r- 4(0 Ow ( (D

  13. Development and Evaluation of Adeno-HTLV-III Hybrid Virus and Non- Cytopathic HTLV-III Mutant for Vaccine Use

    DTIC Science & Technology

    1988-10-28

    I44r.0 + I I U.-4 Io 4- z+ (b I- 0 cj V I-SI: -4 I4 0)~ W4+ I ~ ’ IC14 e 9Q~ 4I cj-0 C:.L SI r. Cl I1C I0 -4 -4 I- .I -.t- 1 J.X- )0 1I 4 I I < < I w ...1-1 0 (3I I >+ ++ >> coZ mI WC ~ + U- H-i m ca IQg OI pI I4 cN.3 I "- .- 00I - I In :3 :3 w w 1 04l ci I I I I I ~ 4(~,-4~4.36 + a% 𔃺 001 to U 4-4...C) l~ u(V14:: - 4L + 4+ bC4 co4 ~0 M~ 40 -40~4. 4.4 bc I0 -l 110 C) 1 0 1 N, o 1) 41 -4 + cn, -H + N- to4 z:: Ia 41 w 1-1+ II,-HI r_ (cc ) (N -a* 1

  14. 77 FR 36530 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... OMITTED. E-13 ER12-1600-000 Southwest Power Pool, Inc. E-14 EL09-61-001 Louisiana Public Service..., LLC. Certificates C-1 CP12-33-000 Caledonia Energy Partners, L.L.C. C-2 CP12-4-000 Southern Natural.... C-6 CP12-51-000 Bluewater Gas Storage, LLC. C-7 CP11-50-000, CP11-50-001.... PetroLogistics Natural...

  15. Voulkensin C-E, new 11-oxocassane-type diterpenoids and a steroid glycoside from Caesalpinia volkensii stem bark and their antiplasmodial activities.

    PubMed

    Ochieng, Charles O; Manguro, Lawrence A O; Owuor, Philip O; Akala, Hosea

    2013-05-15

    A bioassay guided isolation of potential antimalarial molecules from the stem bark of Caesalpinia volkensii Harms (Fabaceae) achieved three new 11-oxocassane-type diterpenoids named voulkensin C (1), D (2) and E (3) together with one steroid glycoside named 3-O-[β-glucopyranosyl(1→2)-O-β-xylopyranosyl]-stigmasterol (4) and seven other known compounds including stigmasterol (5), β-sitosterol (6), oleanolic acid (7), 3-β-acetoxyolean-12-en-28-methyl ester (8), voucap-5-ol (9), caesadekarin C (10), deoxycaesaldekarin C (11). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, (1)H and (13)C NMR and 2D NMR) analyses. The polar extracts revealed moderate to good antiplasmodial activities against chloquine-sensitive (D6) and -resistant strains (W2) of Plasmodium falciparum. Whereas the pure isolates exhibited limited to moderate antiplasmodial activities with compound 4 showing the highest antiplasmodial activities (IC50 values of 4.44±0.88 and 2.74±1.10μM against D6 and W2 strains, respectively). These results suggest a possible contribution of phytochemicals from C. volkensii stem bark towards inhibition of plasmodial parasites' growth hence potential antimalarial. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. FP-LAPW based investigation of structural, electronic and mechanical properties of CePb{sub 3} intermetallic compound

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pagare, Gitanjali, E-mail: gita-pagare@yahoo.co.in; Jain, Ekta, E-mail: jainekta05@gmail.com; Abraham, Jisha Annie, E-mail: disisjisha@yahoo.com

    A theoretical study of structural, electronic, elastic and mechanical properties of CePb{sub 3} intermetallic compound has been investigated systematically using first principles density functional theory. The calculations are carried out within the three different forms of generalized gradient approximation (GGA) and LSDA for the exchange correlation potential. The ground state properties such as lattice parameter (a{sub 0}), bulk modulus (B) and its pressure derivative (B′) are calculated and obtained lattice parameter of this compound shows well agreement with the experimental results. We have calculated three independent second order elastic constants (C{sub 11}, C{sub 12} and C{sub 44}), which has notmore » been calculated and measured yet. From energy dispersion curves, it is found that the studied compound is metallic in nature. Ductility of this compound is analyzed using Pugh’s criteria and Cauchy's pressure (C{sub 11}-C{sub 12}). The mechanical properties such as Young's modulus, shear modulus, anisotropic ratio, Poison's ratio have been calculated for the first time using the Voigt–Reuss–Hill (VRH) averaging scheme. The average sound velocities (v{sub m}), density (ρ) and Debye temperature (θ{sub D}) of this compound are also estimated from the elastic constants.« less

  17. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 13. Modular Engineering-Okinawa GM Corporation.

    DTIC Science & Technology

    1987-01-01

    44 44 0 ( 4 0 I 14 4 n bJ4 11) - 0 0 0 0 4𔃾 o c40N C,) a ima) -t.4 n c00000.co 03- 4 4 )- 0 00 C(,I0)0 0) r c)00 W0 0 enC Go6 ,r 00 c 0 w P00(IW0...cI enC en (0) m) r-- 0 00G L 0 enO -’ M0 U-100 U 00 L) 0( m 1 0 0 -40 0 00 0C - 0-4 00 0 00 0 *44( C II M 4-- I-. (D04- r- P4r- r., (D r- to r-- - r- r...q 14 Z LJOOO LaDO W-7𔃺)hI0~ 0.OXX OOON-400000 0( 00 0. LAO LOCDM𔃺 -󈧄 XLALA)Oao L)0~ o mO U00 ~ 0 ": 0 0 V-40 ’-’CC10 M ICC 0000D04

  18. Micronucleus induction in Vicia faba roots. Part 2. Biological effects of neutrons below 1 cGy.

    PubMed

    Marshall, I; Bianchi, M

    1983-08-01

    A dose-effect relationship has been established for high-energy neutrons (maximum energy 600 MeV) within a dose range of 0.2 to 80 cGy and for low-energy neutrons produced by a 252Cf source (mean energy 2.35 MeV) for doses between 0.2 and 5 cGy. The frequency of micronuclei was found to increase linearly with dose. The relative biological effectiveness (r.b.e) values calculated using 60Co radiation as a reference were, in the high-dose region, 4.7 +/- 0.4 and 11.8 +/- 1.3 for the high- and low-energy neutrons, respectively. At doses below 1 cGy constant values of 25.4 +/- 4.4 and 63.7 +/- 12 were reached for the respective neutron energies.

  19. Synthesis of carbon-11-labeled 5-HT6R antagonists as new candidate PET radioligands for imaging of Alzheimer's disease.

    PubMed

    Wang, Xiaohong; Dong, Fugui; Miao, Caihong; Li, Wei; Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang; Xu, Zhidong

    2018-06-01

    Carbon-11-labeled serotonin (5-hydroxytryptamine) 6 receptor (5-HT 6 R) antagonists, 1-[(2-bromophenyl)sulfonyl]-5-[ 11 C]methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole (O-[ 11 C]2a) and 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-[ 11 C]methyl-1-piperazinyl)methyl]-1H-indole (N-[ 11 C]2a), 5-[ 11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1-(phenylsulfonyl)-1H-indole (O-[ 11 C]2b) and 5-methoxy-3-((4-[ 11 C]methylpiperazin-1-yl)methyl)-1-(phenylsulfonyl)-1H-indole (N-[ 11 C]2b), 1-((4-isopropylphenyl)sulfonyl)-5-[ 11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole (O-[ 11 C]2c) and 1-((4-isopropylphenyl)sulfonyl)-5-methoxy-3-((4-[ 11 C]methylpiperazin-1-yl)methyl)-1H-indole (N-[ 11 C]2c), 1-((4-fluorophenyl)sulfonyl)-5-[ 11 C]methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole (O-[ 11 C]2d) and 1-((4-fluorophenyl)sulfonyl)-5-methoxy-3-((4-[ 11 C]methylpiperazin-1-yl)methyl)-1H-indole (N-[ 11 C]2d), were prepared from their O- or N-desmethylated precursors with [ 11 C]CH 3 OTf through O- or N-[ 11 C]methylation and isolated by HPLC combined with SPE in 40-50% radiochemical yield, based on [ 11 C]CO 2 and decay corrected to end of bombardment (EOB). The radiochemical purity was >99%, and the molar activity (MA) at EOB was 370-740 GBq/μmol with a total synthesis time of ∼40-min from EOB. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Site and extent of digestion, duodenal flow, and intestinal disappearance of total and esterified fatty acids in sheep fed a high-concentrate diet supplemented with high-linoleate safflower oil.

    PubMed

    Atkinson, R L; Scholljegerdes, E J; Lake, S L; Nayigihugu, V; Hess, B W; Rule, D C

    2006-02-01

    Our objective was to determine duodenal and ileal flows of total and esterified fatty acids and to determine ruminal fermentation characteristics and site and extent of nutrient digestion in sheep fed an 80% concentrate diet supplemented with high-linoleate (77%) safflower oil at 0, 3, 6, and 9% of DM. Oil was infused intraruminally along with an isonitrogenous basal diet (fed at 2% of BW) that contained bromegrass hay, cracked corn, corn gluten meal, urea, and limestone. Four crossbred wethers (BW = 44.3 +/- 15.7 kg) fitted with ruminal, duodenal, and ileal cannulas were used in a 4 x 4 Latin square experiment, in which 14 d of dietary adaptation were followed by 4 d of duodenal, ileal, and ruminal sampling. Fatty acid intake increased (linear, P = 0.004 to 0.001) with increased dietary safflower oil. Digestibilities of OM, NDF, and N were not affected (P = 0.09 to 0.65) by increased dietary safflower oil. For total fatty acids (free plus esterified) and esterified fatty acids, duodenal flow of most fatty acids, including 18:2c-9,c-12, increased (P = 0.006 to 0.05) with increased dietary oil. Within each treatment, duodenal flow of total and esterified 18:2c-9,c-12 was similar (P = 0.32), indicating that duodenal flow of this fatty acid occurred because most of it remained esterified. Duodenal flow of esterified 18:1t-11 increased (P = 0.08) with increased dietary safflower oil, indicating that reesterification of ruminal fatty acids occurred. Apparent small intestinal disappearance of most fatty acids was not affected (P = 0.19 to 0.98) by increased dietary safflower oil, but increased (P = 0.05) for 18:2c-9,c-12, which ranged from 87.0 to 97.4%, and for 18:2c-9,t-11 (P = 0.03), which ranged from 37.9% with no added oil to 99.2% with supplemental oil. For esterified fatty acids, apparent small intestinal disappearance was from 80% for 18:3c-9,c-12,c-15 at the greatest level of dietary oil up to 100% for 18:1t-11 and 18:1c-12 with 0% oil. We concluded that duodenal flow of 18:2c-9,c-12 was predominately associated with the esterified fraction, suggesting that the extent of ruminal lipolysis was decreased with increased dietary high-linoleate safflower oil. Furthermore, biohydrogenation intermediates observed in the esterified fatty acids indicated that some reesterification occurred, and the high level of apparent absorption of esterified fatty acids indicated that intestinal lipolysis did not limit overall digestion of the fatty acids fed to the sheep.

  1. Finite Element Program for Calculating Flows in Turbomachines with Results for NASA Task-1 Compressor.

    DTIC Science & Technology

    1982-10-01

    CR !PT Jr,4 CF THE FUPEP ELiAEN5 + f ,, 4, S**444444**44*4*4*444++ 44 4.+414++++++4++ + +++4+++44 f 44*4* ++ +444. + 172 FILE: IdES!’ GEN FC4TRAN Al...CLCC-(-"II e(1) 21...X’) STE’T ST’ICT *SSICT 179 FILE: PESI- GEN FCRTPAN Al NAVNL POSTGRAOLATE SCHO󈧣 70C CCITTNJUE P~lUPN C *****+*+*+4*+ *.4+..*4.4...PEtC IN fCCiNFC7Iv1TY IPATP:X, Lr..%L NdCDE NLVhJ3E S STAPT AT ELVEPTIS i.;PIi iR!G~e r~ fANC LC,.% IND) TAV -QSi Mih. C REIC IN 11-E FLEPOENT TypE

  2. Electronic and mechanical properties of ZnX (X = S, Se and Te)—An ab initio study

    NASA Astrophysics Data System (ADS)

    Verma, Ajay Singh; Sharma, Sheetal; Sarkar, Bimal Kumar; Jindal, Vijay Kumar

    2011-12-01

    Zinc chalcogenides (ZnX, X = S, Se and Te) have been increasing attention as wide and direct band gap semiconductor for blue and ultraviolet optical devices. This paper analyzes electronic and mechanical properties of these materials by ab initio pseudo-potential method that uses non conserving pseudopotentials in fully nonlocal form, as implemented in SIESTA code. In this approach the local density approximation (LDA) is used for the exchange-correlation (XC) potential. The calculations are given for band gap, elastic constants (C11, C12 and C44), shear modulus, and Young's modulus. The results are in very good agreement with previous theoretical calculations and available experimental data.

  3. An ab-initio investigation on SrLa intermetallic compound

    NASA Astrophysics Data System (ADS)

    Kumar, S. Ramesh; Jaiganesh, G.; Jayalakshmi, V.

    2018-05-01

    The electronic, elastic and thermodynamic property of CsCl-type SrLa are investigated through density functional theory. The energy-volume relation for this compound has been obtained. The band structure, density of states and charge density in (110) plane are also examined. The elastic constants (C11, C12 and C44) of SrLa is computed, then, using these elastic constants, the bulk moduli, shear moduli, Young's moduli and Poisson's ratio are also derived. The calculated results showed that CsCl-type SrLa is ductile at ambient conditions. The thermodynamic quantities such as free energy, entropy and heat capacity as a function of temperature are estimated and the results obtained are discussed.

  4. Abnormal Elasticity of Single-Crystal Magnesiosiderite across the Spin Transition in Earth's Lower Mantle

    NASA Astrophysics Data System (ADS)

    Fu, Suyu; Yang, Jing; Lin, Jung-Fu

    2017-01-01

    Brillouin light scattering and impulsive stimulated light scattering have been used to determine the full elastic constants of magnesiosiderite [(Mg0.35Fe0.65)CO3 ] up to 70 GPa at room temperature in a diamond-anvil cell. Drastic softening in C11 , C33 , C12 , and C13 elastic moduli associated with the compressive stress component and stiffening in C44 and C14 moduli associated with the shear stress component are observed to occur within the spin transition between ˜42.4 and ˜46.5 GPa . Negative values of C12 and C13 are also observed within the spin transition region. The Born criteria constants for the crystal remain positive within the spin transition, indicating that the mixed-spin state remains mechanically stable. Significant auxeticity can be related to the electronic spin transition-induced elastic anomalies based on the analysis of Poisson's ratio. These elastic anomalies are explained using a thermoelastic model for the rhombohedral system. Finally, we conclude that mixed-spin state ferromagnesite, which is potentially a major deep-carbon carrier, is expected to exhibit abnormal elasticity, including a negative Poisson's ratio of -0.6 and drastically reduced VP by 10%, in Earth's midlower mantle.

  5. 12 CFR 208.44 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Action § 208.44 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A member bank... § 208.43(c) shall include a description of the steps the bank will take to correct the unsafe or unsound... section 38(e)(2)(C) of that Act by each company that controls the bank. (c) Review of capital restoration...

  6. Copolymers for Drag Reduction in Marine Propulsion: New Molecular Structures with Enhanced Effectiveness

    DTIC Science & Technology

    1992-05-31

    11 then distilled over as hat 100 C. Yield: 7.7 g(85%). Mp: 172"C. AnaL Calod for a clear liquid which cooled to form a hygroscopic, hard white Ci Ho...of 10 (0.44 , 1.36 X 10- ol ) was added to ,’Rlucon- ration). lactone (12; 0.30 1.68 X 10 4 mol) in 2 mL of CHsOIL A clear 8r...the addition funnel was replaced witha condenser. Refluxing overnight resulted in a white solid precipitate. N-tophysilresponseoftheopyrenelabeL

  7. Computer Implementation and Simulation of Some Neural Networks Used in Pattern Recognition and Classification

    DTIC Science & Technology

    1989-03-01

    8,8) REAL ARR(64), X(64), PMAT(8,8), BMAT (8,8), U(10,11) C C C * INITIALIZATION C C PRINT*,’ CARPENTER / GROSSBERG NETWORK IMPLEMENTATION’ PRINT...CONTINUE 38 FORMAT(1X,8I5) 7 DO0441I=1, 8 DO 45 J1I, 8 BMAT (I,J) = REAL(MATRIX(I,J)) 45 CONTINUE 44 CONTINUE CALL MATVEC( BMAT ,X) C C C *COMPUTE MATCHING

  8. The effect of long-range order on the elastic properties of Cu3Au

    NASA Astrophysics Data System (ADS)

    Wang, Gui-Sheng; Krisztina Delczeg-Czirjak, Erna; Hu, Qing-Miao; Kokko, Kalevi; Johansson, Börje; Vitos, Levente

    2013-02-01

    Ab initio calculations, based on the exact muffin-tin orbitals method are used to determine the elastic properties of Cu-Au alloys with Au/Cu ratio 1/3. The compositional disorder is treated within the coherent potential approximation. The lattice parameters and single-crystal elastic constants are calculated for different partially ordered structures ranging from the fully ordered L12 to the random face centered cubic lattice. It is shown that the theoretical elastic constants follow a clear trend with the degree of chemical order: namely, C11 and C12 decrease, whereas C44 remains nearly constant with increasing disorder. The present results are in line with the experimental findings that the impact of the chemical ordering on the fundamental elastic parameters is close to the resolution of the available experimental and theoretical tools.

  9. Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA) and forskolin.

    PubMed

    Prates, E G; Alves, S P; Marques, C C; Baptista, M C; Horta, A E M; Bessa, R J B; Pereira, R M

    2013-05-01

    The effect of maturation and of two lipid modulators supplementation along in vitro maturation (IVM) on fatty acid (FA) and dimethylacetal (DMA) composition of porcine cumulus oocyte complexes (COC) were studied. Abattoir-derived immature COC were analyzed for FA and DMA or submitted to IVM as follows: control group; t10,c12 CLA group, t10,c12 CLA supplementation for 44 h; Forskolin group, forskolin supplementation during the initial 2 h; t10,c12 CLA + forskolin group, t10,c12 CLA for 44 h and forskolin for just 2h. Each experimental group had five replicates. FA analysis of oocytes, cumulus cells (CC), follicular fluid, and culture media were performed by gas-liquid chromatography. Oocytes and their CC had different FA composition. Oocytes were richer in saturated FA (SFA) preferentially maintaining their FA profile during maturation. Mature CC had the highest polyunsaturated FA (PUFA) content. Five individual and total SFA, and monounsaturated FA (MUFA), notably oleic acid (c9-18:1), percentages were lower (P ≤ 0.023) in mature than in immature CC. t10,c12 CLA was accumulated by COC from t10,c12 CLA and t10,c12 CLA + forskolin groups, mostly in CC where MUFA and an eicosatrienoic isomer decreased (P ≤ 0.043). Nevertheless, PUFA or FA and DMA total content were not affected. Arachidonic acid was reduced in t10,c12 CLA + forskolin CC and hexadecanal-DMA-16:0 in t10,c12 CLA CC. Forskolin alone increased (P ≤ 0.043) c9-18:1 in oocytes. In conclusion, maturation process clearly changed porcine COC FA and DMA profiles, mostly of CC, also more susceptible to modifications induced by t10,c12 CLA. This possibility of manipulating COC lipid composition during IVM could be used to improve oocyte quality/cryopreservation efficiency.

  10. 15 CFR 740.20 - License Exception Strategic Trade Authorization (STA).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Exception STA may not be used for any item controlled by ECCN 1C351.a, .b, .c, d.11, .d.12 or .e, ECCNs 1C352, 1C353, 1C354, 1C360, 1E001 (i.e., for technology, as specified in ECCN 1E001, for items controlled by ECCN 1C351.a, .b, .c, .d.11, .d.12 or .e or ECCNs 1C352, 1C353, 1C354 or 1C360) or ECCN 1E351...

  11. 15 CFR 740.20 - License Exception Strategic Trade Authorization (STA).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Exception STA may not be used for any item controlled by ECCN 1C351.a, .b, .c, d.11, .d.12 or .e, ECCNs 1C352, 1C353, 1C354, 1C360, 1E001 (i.e., for technology, as specified in ECCN 1E001, for items controlled by ECCN 1C351.a, .b, .c, .d.11, .d.12 or .e or ECCNs 1C352, 1C353, 1C354 or 1C360) or ECCN 1E351...

  12. Carrier protein influences immunodominance of a known epitope: implication in peptide vaccine design.

    PubMed

    Ghosh, Moumita; Solanki, Ashish K; Roy, Koushik; Dhoke, Reema R; Ashish; Roy, Syamal

    2013-09-23

    We investigated how the processing of a given antigen by antigen presenting cells (APC) is dictated by the conformation of the antigen and how this governs the immunodominance hierarchy. To address the question, a known immunodominant sequence of bacteriophage lambda repressor N-terminal sequence 12-26 [λR(12-26)] was engineered at the N and C termini of a heterologous leishmanial protein, Kinetoplastid membrane protein-11 (KMP-11); the resulting proteins were defined as N-KMP-11 and C-KMP-11 respectively. The presence of λR(12-26) in N-KMP-11 and C-KMP-11 was established by western blot analysis with antibody to λR(12-26) peptide. N-KMP-11 but not C-KMP-11 could stimulate the anti λR(12-26) T-cell clonal population very efficiently in the presence of APCs. Priming of BALB/c mice with N-KMP-11 or C-KMP-11 generated similar levels of anti-KMP-11 IgG, but anti-λR(12-26) specific IgG was observed only upon priming with N-KMP-11. Interestingly, uptake of both N-KMP-11 and C-KMP-11 by APCs was similar but catabolism of N-KMP-11 but not C-KMP-11 was biphasic and fast at the initial time point. Kratky plots of small angle X-ray scattering showed that while N-KMP-11 adopts flexible Gaussian type of topology, C-KMP-11 prefers Globular nature. To show that KMP-11 is not unique as a carrier protein, an epitope (SPITBTNLBTMBK) of Plasmodium yoelii (PY) apical membrane protein 1[AMA-1 (136-148)], is placed at the C and N terminals of a dominant T-cell epitope of ovalbumin protein OVA(323-339) and the resulting peptides are defined as PY-OVA and OVA-PY respectively. Interestingly, only OVA-PY could stimulate anti-OVA T-cells and produce IgG response upon priming of BALB/c mice with it. Thus for rational design of peptide vaccine it is important to place the dominant epitope appropriately in the context of the carrier protein. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Prime Contract Awards by State or Country, Place and Contractor. Part 18 (Germany - Yugoslavia), FY1991

    DTIC Science & Technology

    1991-01-01

    04 IN C> enC o 0 0f0 C. 0 40 el 40 0000ufen>.0l u 0 -M4N0)I N 0 44 N > 40 0 00 C> 0 CD 4 -OOC>OC N M-INO- N 0 0 .-eflO eneOC a 0D C> No 0 -o404-441...0 1 04 D N40 U0 00000000000 >C10 0 00 0 000000 0 U I GO-* U -4M-4000C 40 0 0 0 00. -4 > 0C𔃺C m- I~ I ~ c) U 4 C1) c) M’c 40 0000cn-4 V) c enC m C...m’).4 If 11 I00)r N Z -4 -4-4 -4N040 C, eNc -40 N k "c’) 0 N .o"N-I -4C0N10 -4 W N I (0 If 0 0) ()0)() 0 In 0) 0) -411 (0(0(0 soLAn 00 N0() 00 C’J-4

  14. Crystal structures of 4-meth-oxy-benzoic acid-1,3-bis-(pyridin-4-yl)propane (2/1) and biphenyl-4,4'-di-carb-oxy-lic acid-4-meth-oxy-pyridine (1/2).

    PubMed

    Gotoh, Kazuma; Ishida, Hiroyuki

    2017-07-01

    The crystal structures of two hydrogen-bonded compounds, namely 4-meth-oxy-benzoic acid-1,3-bis-(pyridin-4-yl)propane (2/1), C 13 H 14.59 N 2 ·C 8 H 7.67 O 3 ·C 8 H 7.74 O 3 , (I), and biphenyl-4,4'-di-carb-oxy-lic acid-4-meth-oxy-pyridine (1/2), C 14 H 9.43 O 4 ·C 6 H 7.32 NO·C 6 H 7.25 NO, (II), have been determined at 93 K. In (I), the asymmetric unit consists of two crystallographically independent 4-meth-oxy-benzoic acid mol-ecules and one 1,3-bis-(pyridin-4-yl)propane mol-ecule. The asymmetric unit of (II) comprises one biphenyl-4,4'-di-carb-oxy-lic acid mol-ecule and two independent 4-meth-oxy-pyridine mol-ecules. In each crystal, the acid and base mol-ecules are linked by short O-H⋯N/N-H⋯O hydrogen bonds, in which H atoms are disordered over the acid O-atom and base N-atom sites, forming a linear hydrogen-bonded 2:1 or 1:2 unit of the acid and the base. The 2:1 units of (I) are linked via C-H⋯π, π-π and C-H⋯O inter-actions into a tape structure along [101], while the 1:2 units of (II) form a double-chain structure along [-101] through π-π and C-H⋯O inter-actions.

  15. Carbon-Hydrogen Activation in Zerovalent Bis(1,5-cyclooctadiene) Complexes of the First Row Transition Metals: A Theoretical Study.

    PubMed

    Hu, Jia; Feng, Hao; Xie, Yaoming; King, R Bruce; Schaefer, Henry F

    2018-03-29

    Stepwise interaction of first row transition metal atoms with 1,5-cyclooctadiene to give (C 8 H 12 ) 2 M complexes is studied using the M06-L/DZP density functional method. The experimentally known (C 8 H 12 ) 2 Ni is the thermodynamically most favorable complex, with a predicted geometry consistent with its experimental structure as determined by X-ray crystallography. The other transition metal atoms from scandium to zinc also interact exothermically with 1,5-cyclooctadiene to give (C 8 H 12 ) 2 M derivatives, but these exhibit lower symmetry than the S 4 symmetry exhibited by (C 8 H 12 ) 2 Ni. Carbon-hydrogen activation of CH 2 groups in a C 8 H 12 ligand is predicted for most systems. Thus, conversion of (η 2,2 -C 8 H 12 ) 2 M to (η 3,2 -C 8 H 11 )(η 2,1 -C 8 H 13 )M, through a hydride intermediate (η 3,2 -C 8 H 11 )(η 2,2 -C 8 H 12 )MH, is predicted for scandium, vanadium, chromium, manganese, and cobalt. For titanium with a low-lying empty orbital, further C-H activation through a hydride intermediate (η 6 -C 8 H 10 )(η 2,1 -C 8 H 13 )TiH is predicted, leading ultimately to (η 6 -C 8 H 10 )(η 1,1 -C 8 H 14 )Ti, in which the hexahapto η 6 -C 8 H 10 ligand is shown by NICS to be aromatic. These two C-H activation processes on a titanium center represent the dehydrogenation of 1,5-cyclooctadiene to 1,3,5-cyclooctatriene with the second 1,5-cyclooctadiene ligand as the hydrogen acceptor. For zinc C-H activation terminates at (η 1 -C 8 H 11 )(C 8 H 12 )ZnH, which has a C-Zn-H three-center bond. No energetically favorable C-H activation processes are predicted for the iron, nickel, and copper (η 2,2 -C 8 H 12 ) 2 M derivatives.

  16. High-density lipoprotein-cholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotype.

    PubMed

    Halverstadt, Amy; Phares, Dana A; Ferrell, Robert E; Wilund, Kenneth R; Goldberg, Andrew P; Hagberg, James M

    2003-11-01

    Plasma high-density lipoprotein cholesterol (HDL-C) levels are an important independent risk factor for cardiovascular disease (CVD) that can be modified through exercise training. However, levels of HDL-C and its subfractions and their response to standardized exercise training are highly variable among individuals. Such variability suggests that levels of HDL-C, its subfractions, and their response to exercise training may be influenced by genetic variation and the interaction of that genetic variation with physical activity. The endothelial lipase gene (LIPG) may influence HDL-C metabolism and has several recently identified genetic variants. We hypothesized that the LIPG Thr111Ile polymorphism would be associated with variation in HDL-C levels and its subfractions and their response to exercise training. Eighty-three sedentary, healthy 50- to 75-year-old subjects were weight-maintained on an American Heart Association Step 1 Diet and then studied before and after aerobic exercise training. Sample size varied according to outcome measure as complete data was not available for all subjects. Initial age, body composition, and maximum oxygen consumption (V02max) did not differ between LIPG genotype groups (CC, n=41 to 44; CT/TT, n=37 to 39). Initial total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were not significantly different between groups. The CT/TT group had lower initial HDL(2NMR)-C (12 +/- 1.0 v 17 +/- 1.1 mg/dL; P =.002) and integrated HDL(1,2NMR)-C (13 +/- 1.0 v 18 +/- 1.1 mg/dL; P=.002) levels and somewhat higher initial levels of integrated HDL(3,4,5)-C (31 +/- 2.2 v 25 +/- 2.3 mg/dL; P=.06). With exercise training, Vo2max increased, and body weight, total body fat, and visceral adipose tissue decreased similarly in both groups. With training, HDL-C levels increased twice as much (4.4 +/- 0.8 v 1.9 +/- 0.9 mg/dL; P=.04), HDL3-C levels increased almost 2-fold greater (3.8 +/- 0.7 v 2.2 +/- 0.6 mg/dL; P=.07), and HDL(5NMR)-C levels increased more than 4 times as much (2.2 +/- 0.8 v 0.5 +/- 0.6 mg/dL; P=.08) in the CC compared to the CT/TT group. We conclude that the LIPG genotype is associated with interindividual variability in HDL-C and its subfractions and their response to exercise training.

  17. Human SLC4A11-C functions as a DIDS-stimulatable H+(OH−) permeation pathway: partial correction of R109H mutant transport

    PubMed Central

    Kao, Liyo; Azimov, Rustam; Abuladze, Natalia; Newman, Debra

    2014-01-01

    The SLC4A11 gene mutations cause a variety of genetic corneal diseases, including congenital hereditary endothelial dystrophy 2 (CHED2), Harboyan syndrome, some cases of Fuchs' endothelial dystrophy (FECD), and possibly familial keratoconus. Three NH2-terminal variants of the human SLC4A11 gene, named SLC4A11-A, -B, and -C are known. The SLC4A11-B variant has been the focus of previous studies. Both the expression of the SLC4A11-C variant in the cornea and its functional properties have not been characterized, and therefore its potential pathophysiological role in corneal diseases remains to be explored. In the present study, we demonstrate that SLC4A11-C is the predominant SLC4A11 variant expressed in human corneal endothelial mRNA and that the transporter functions as an electrogenic H+(OH−) permeation pathway. Disulfonic stilbenes, including 4,4′-diisothiocyano-2,2′-stilbenedisulfonate (DIDS), 4,4′-diisothiocyanatodihydrostilbene-2,2′-disulfonate (H2DIDS), and 4-acetamido-4′-isothiocyanato-stilbene-2,2′-disulfonate (SITS), which are known to bind covalently, increased SLC4A11-C-mediated H+(OH−) flux by 150–200% without having a significant effect in mock-transfected cells. Noncovalently interacting 4,4′-diaminostilbene-2,2′-disulfonate (DADS) was without effect. We tested the efficacy of DIDS on the functionally impaired R109H mutant (SLC4A11-C numbering) that causes CHED2. DIDS (1 mM) increased H+(OH−) flux through the mutant transporter by ∼40–90%. These studies provide a basis for future testing of more specific chemically modified dilsulfonic stilbenes as potential therapeutic agents to improve the functional impairment of specific SLC4A11 mutant transporters. PMID:25394471

  18. Theoretical simulations of the structural stabilities, elastic, thermodynamic and electronic properties of Pt3Sc and Pt3Y compounds

    NASA Astrophysics Data System (ADS)

    Boulechfar, R.; Khenioui, Y.; Drablia, S.; Meradji, H.; Abu-Jafar, M.; Omran, S. Bin; Khenata, R.; Ghemid, S.

    2018-05-01

    Ab-initio calculations based on density functional theory have been performed to study the structural, electronic, thermodynamic and mechanical properties of intermetallic compounds Pt3Sc and Pt3Y using the full-potential linearized augmented plane wave(FP-LAPW) method. The total energy calculations performed for L12, D022 and D024 structures confirm the experimental phase stability. Using the generalized gradient approximation (GGA), the values of enthalpies formation are -1.23 eV/atom and -1.18 eV/atom for Pt3Sc and Pt3Y, respectively. The densities of states (DOS) spectra show the existence of a pseudo-gap at the Fermi level for both compounds which indicate the strong spd hybridization and directing covalent bonding. Furthermore, the density of states at the Fermi level N(EF), the electronic specific heat coefficient (γele) and the number of bonding electrons per atom are predicted in addition to the elastic constants (C11, C12 and C44). The shear modulus (GH), Young's modulus (E), Poisson's ratio (ν), anisotropy factor (A), ratio of B/GH and Cauchy pressure (C12-C44) are also estimated. These parameters show that the Pt3Sc and Pt3Y are ductile compounds. The thermodynamic properties were calculated using the quasi-harmonic Debye model to account for their lattice vibrations. In addition, the influence of the temperature and pressure was analyzed on the heat capacities (Cp and Cv), thermal expansion coefficient (α), Debye temperature (θD) and Grüneisen parameter (γ).

  19. St. Louis Harbor Project Pedestrian Survey, Madison County, Illinois. St. Louis District Cultural Resource Management Reports Number 24

    DTIC Science & Technology

    1985-07-01

    r - ON N- N a- f n" 0 E C > 00 0 0 0 0 000 Q0a aa0C oa0 000 0 a00 Q 0aaa00L 0. -00 -4-- - .26 v 00 04...34- rn -I ൖ ao o o o a. 4,0 , , (, -*-,4 C *44- ci+- liv 01C 0 E Ia 0 C0 I 0o -- uClJO’ - - 0Ij. I4.4D):t~~ tCaM-I-- - - 0 4- L- 4-0 r - - C 0L)- 4)LL C ... E 0 1- 0 ID E - 0+- C - L) 4v + L C I +- QL 4- 0 r z8 I-- 11 0 C4- +- L3~ I-L QL ~ 0 022 mor_( 00 Cl U)I 0%0 4- 04 4 4 63 *00 B a 4)

  20. Prime Contract Awards Over $25,000 by Major System, Contractor and State Part 2 (AVG NAVY-SMR NAVY)

    DTIC Science & Technology

    1990-01-01

    0 oo0 C) C11 in LA -40w’ I (w -4 N’(. N wO C’-4 4 Go I I I I 5 C- LiCl I m -4 . -40 4 9. C 4,44 44to CL 0 -4 0 -4 Ei EE 0 . Ein % - ) O -Oa W> 444 Pn...3t1, U൰ 4C’J -4)C 0 ) U) 0 0 )M.-4-40-04" I4 Z 7-Ci M’ N N00 C D -4 -4I-4Z4 3:JU I )-( C13- 0 3 )000f 0 ’U) in in i "~ 0 -a < 101ui0 5 -4 O L)- 0 ...M4)u . 0 4W II*-1 4)-- .W0 L-C -4 W I CL. L 0 ) 5 CL a)

  1. Crystal structures of five 1-alkyl-4-aryl-1,2,4-triazol-1-ium halide salts

    PubMed Central

    Guino-o, Marites A.; Talbot, Meghan O.; Slitts, Michael M.; Pham, Theresa N.; Audi, Maya C.; Janzen, Daron E.

    2015-01-01

    The asymmetric units for the salts 4-(4-fluoro­phen­yl)-1-isopropyl-1,2,4-triazol-1-ium iodide, C11H13FN3 +·I−, (1), 1-isopropyl-4-(4-methyl­phen­yl)-1,2,4-triazol-1-ium iodide, C12H16N3 +·I−, (2), 1-isopropyl-4-phenyl-1,2,4-triazol-1-ium iodide, C11H14N3 +·I−, (3), and 1-methyl-4-phenyl-1,2,4-triazol-1-ium iodide, C9H10N3 +·I−, (4), contain one cation and one iodide ion, whereas in 1-benzyl-4-phenyl-1,2,4-triazol-1-ium bromide monohydrate, C15H14N3 +·Br−·H2O, (5), there is an additional single water mol­ecule. There is a predominant C—H⋯X(halide) inter­action for all salts, resulting in a two-dimensional extended sheet network between the triazolium cation and the halide ions. For salts with para-substitution on the aryl ring, there is an additional π–anion inter­action between a triazolium carbon and iodide displayed by the layers. For salts without the para-substitution on the aryl ring, the π–π inter­actions are between the triazolium and aryl rings. The melting points of these salts agree with the predicted substituent inductive effects. PMID:26090137

  2. 77 FR 35106 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... 104-13, Sec. 2, 109 Stat. 163 (1995) (codified as revised at 44 U.S.C. 3501-3520), and its.... 44 U.S.C. 3506(c)(2)(A); 5 CFR 1320.8(d)(1), 1320.10(e)(1), 1320.12(a). Specifically, FRA invites... functions, including whether the activities will have practical utility; (ii) the accuracy of FRA's...

  3. Electronic structure and optical properties of CuAlO2 under biaxial strain.

    PubMed

    Ghosh, C K; Sarkar, D; Mitra, M K; Chattopadhyay, K K

    2012-06-13

    An ab initio calculation has been carried out to investigate the biaxial strain ( - 10.71% < ε < 9.13%) effect on elastic, electronic and optical properties of CuAlO(2). All the elastic constants (c(11), c(12), c(13), c(33)) except c(44) decrease (increase) during tensile (compressive) strain. The band gap is found to decrease in the presence of tensile as well as compressive strain. The relative decrease of the band gap is asymmetric with respect to the sign of the strain. Significant differences between the parallel and perpendicular components of the dielectric constant and the optical properties have been observed due to anisotropic crystal structure. It is further noticed that these properties are easily tunable by strain. Importantly, the collective oscillation of the valence electrons has been identified for light polarized perpendicular to the c-axis. From calculations, it is clear that the tensile strain can enhance the hole mobility as well as the transparency of CuAlO(2).

  4. Electronic structure and optical properties of CuAlO2 under biaxial strain

    NASA Astrophysics Data System (ADS)

    Ghosh, C. K.; Sarkar, D.; Mitra, M. K.; Chattopadhyay, K. K.

    2012-06-01

    An ab initio calculation has been carried out to investigate the biaxial strain ( - 10.71% < ɛ < 9.13%) effect on elastic, electronic and optical properties of CuAlO2. All the elastic constants (c11, c12, c13, c33) except c44 decrease (increase) during tensile (compressive) strain. The band gap is found to decrease in the presence of tensile as well as compressive strain. The relative decrease of the band gap is asymmetric with respect to the sign of the strain. Significant differences between the parallel and perpendicular components of the dielectric constant and the optical properties have been observed due to anisotropic crystal structure. It is further noticed that these properties are easily tunable by strain. Importantly, the collective oscillation of the valence electrons has been identified for light polarized perpendicular to the c-axis. From calculations, it is clear that the tensile strain can enhance the hole mobility as well as the transparency of CuAlO2.

  5. Official Guard and Reserve Manpower Strengths and Statistics, FY 1984 Summary

    DTIC Science & Technology

    1984-01-01

    J 4 1. 4 -A *1u 4 4a M 4 , )MP W% ng P 4 * . 4 (z 4 0 a11 C 4 4 a~~𔃾 7 * 2 04 4pl4~~ 04 *j 4 If N) *z 0 2 .A4 4124 - th - Wi4ý C 4t,404 D 0n ’.4- a...o )U4 Y g o*1 on44 nW v4c nv 4q W .4 4 4.-4 𔃺I ?0 ’~ ~ .pc4.ý% e)0)p)e YW)p)( r nI 4V. D 4 0 a 99 a .4. 1 .1 41. Y Y . q 4C 4 4 4, U.44 CDb 4Y 44 4

  6. Rate Coefficients of C2H with C2H4, C2H6, and H2 from 150 to 359 K

    NASA Technical Reports Server (NTRS)

    Opansky, Brian J.; Leone, Stephen R.

    1996-01-01

    Rate coefficients for the reactions C2H with C2H4, C2H6, and H2 are measured over the temperature range 150-359 K using transient infrared laser absorption spectroscopy. The ethynyl radical is formed by photolysis of C2H2 with a pulsed excimer laser at 193 nm, and its transient absorption is monitored with a color center laser on the Q(sub 11)(9) line of the A(sup 2) Pi-Chi(sup 2) Sigma transition at 3593.68 cm(exp -1). Over the experimental temperature range 150-359 K the rate constants of C2H with C2H4, C2H6, and H2 can be fitted to the Arrhenius expressions k(sub C2H4) = (7.8 +/- 0.6) x 10(exp -11) exp[(134 +/- 44)/T], k(sub C2H6) = (3.5 +/- 0.3) x 10(exp -11) exp[(2.9 +/- 16)/T], and k(sub H2) = (1.2 +/- 0.3) x 10(exp -11) exp[(-998 +/- 57)]/T cm(exp 3) molecule(exp -1) sec(exp -1). The data for C2H with C2H4 and C2H6 indicate a negligible activation energy to product formation shown by the mild negative temperature dependence of both reactions. When the H2 data are plotted together with the most recent high-temperature results from 295 to 854 K, a slight curvature is observed. The H2 data can be fit to the non-Arrhenius form k(sub H2) = 9.2 x 10(exp -18) T(sup 2.17 +/- 0.50) exp[(-478 +/- 165)/T] cm(exp 3) molecules(exp -1) sec(exp -1). The curvature in the Arrhenius plot is discussed in terms of both quantum mechanical tunneling of the H atom from H2 to the C2H radical and bending mode contributions to the partition function.

  7. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Germany - Classified Location Foreign)

    DTIC Science & Technology

    1993-01-01

    n C . 0 4 - ’ ’ U-- 5 U U U0 U U U 0 0 0 0 0)00 0 S.W E 0 M m 01 &- cC-4 aC ad a 0C 4 4 4 (A-0 40 0 E - 0 CL 0 o 0 c - V L0 Z r o 0e V! . - & 4 4 ,1 4...00 Q0 M000000420000 .1 U w 4 000-s 4 11 4N <Cio N < 5 \\jOCOa-1 -1-4i(71N " ൒O 4C’ 4(1.1 4000000000><><>C>c M4 100-4 4f 0))) 0) 0) ) 0) 0) O () ()0...no04w is of 1 004w I LL) to 14L 001*0 4’ <<Cc� 44 4 0040)4 <<<Cc44444 44 4 44 o0- " 5 :: J-- -.J - JJJJ-j-J -J.J--Ii- . ft U-4 M 0 :: XXZX of 0

  8. c9t11-Conjugated linoleic acid-rich oil fails to attenuate wasting in colon-26 tumor-induced late-stage cancer cachexia in male CD2F1 mice.

    PubMed

    Tian, Min; Kliewer, Kara L; Asp, Michelle L; Stout, Michael B; Belury, Martha A

    2011-02-01

    Cancer cachexia is characterized by muscle and adipose tissue wasting caused partly by chronic, systemic inflammation. Conjugated linoleic acids (CLAs) are a group of fatty acids with various properties including anti-inflammatory cis9, trans11 (c9t11)-CLA and lipid-mobilizing trans10, cis12 (t10c12)-CLA. The purpose of this study was to test whether dietary supplementation of a c9t11-CLA-rich oil (6:1 c9t11:t10c12) could attenuate wasting of muscle and adipose tissue in colon-26 adenocarcinoma-induced cachexia in mice. Loss of body weight, muscle and adipose tissue mass caused by tumors were not rescued by supplementation with the c9t11-CLA-rich oil. In quadriceps muscle, c9t11-CLA-rich oil exacerbated tumor-induced gene expression of inflammatory markers tumor necrosis factor-α, IL-6 receptor and the E3 ligase MuRF-1 involved in muscle proteolysis. In epididymal adipose tissue, tumor-driven delipidation and atrophy was aggravated by the c9,t11-CLA-rich oil, demonstrated by further reduced adipocyte size and lower adiponectin expression. However, expression of inflammatory cytokines and macrophage markers were not altered by tumors, or CLA supplementation. These data suggest that addition of c9t11-CLA-rich oil (0.6% c9t11, 0.1% t10c12) in diet did not ameliorate wasting in mice with cancer cachexia. Instead, it increased expression of inflammatory markers in the muscle and increased adipose delipidation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Retinylidene ligand structure in bovine rhodopsin, metarhodopsin-I, and 10-methylrhodopsin from internuclear distance measurements using 13C-labeling and 1-D rotational resonance MAS NMR.

    PubMed

    Verdegem, P J; Bovee-Geurts, P H; de Grip, W J; Lugtenburg, J; de Groot, H J

    1999-08-31

    Rhodopsin is the G-protein coupled photoreceptor that initiates the rod phototransduction cascade in the vertebrate retina. Using specific isotope enrichment and magic angle spinning (MAS) NMR, we examine the spatial structure of the C10-C11=C12-C13-C20 motif in the native retinylidene chromophore, its 10-methyl analogue, and the predischarge photoproduct metarhodopsin-I. For the rhodopsin study 11-Z-[10,20-(13)C(2)]- and 11-Z-[11,20-(13)C(2)]-retinal were synthesized and incorporated into bovine opsin while maintaining a natural lipid environment. The ligand is covalently bound to Lys(296) in the photoreceptor. The C10-C20 and C11-C20 distances were measured using a novel 1-D CP/MAS NMR rotational resonance experimental procedure that was specifically developed for the purpose of these measurements [Verdegem, P. J. E., Helmle, M., Lugtenburg, J., and de Groot, H. J. M. (1997) J. Am. Chem. Soc. 119, 169]. We obtain r(10,20) = 0.304 +/- 0.015 nm and r(11,20) = 0.293 +/- 0.015 nm, which confirms that the retinylidene is 11-Z and shows that the C10-C13 unit is conformationally twisted. The corresponding torsional angle is about 44 degrees as indicated by Car-Parrinello modeling studies. To increase the nonplanarity in the chromophore, 11-Z-[10,20-(13)C(2)]-10-methylretinal and 11-Z-[(10-CH(3)), 13-(13)C(2)]-10-methylretinal were prepared and incorporated in opsin. For the resulting analogue pigment r(10,20) = 0.347 +/- 0.015 nm and r((10)(-)(CH)()3())(,)(13) = 0.314 +/- 0.015 nm were obtained, consistent with a more distorted chromophore. The analogue data are in agreement with the induced fit principle for the interaction of opsin with modified retinal chromophores. Finally, we determined the intraligand distances r(10,20) and r(11,20) also for the photoproduct metarhodopsin-I, which has a relaxed all-E structure. The results (r(10,20) >/= 0.435 nm and r(11,20) = 0.283 +/- 0.015 nm) fully agree with such a relaxed all-E structure, which further validates the 1-D rotational resonance technique for measuring intraligand distances and probing ligand structure. As far as we are aware, these results represent the first highly precise distance determinations in a ligand at the active site of a membrane protein. Overall, the MAS NMR data indicate a tight binding pocket, well defined to bind specifically only one enantiomer out of four possibilities and providing a steric complement to the chromophore in an ultrafast ( approximately 200 fs) isomerization process.

  10. Dollar Summary of Federal Supply Classification and Service Category by Company. Part 5 (Z119-Z299)

    DTIC Science & Technology

    1990-01-01

    a 1- U) 1- 0 W)U ) ~ U ) ~ ~ U ) ~ ~ U 4 U 00I- 43m m 0 0WIZ 4o x - Ip I 4 ce - Ne- " OI ZI4 0> I- E 0W 6 w m. U .4 CK()1 . 0 (A- F- " a U C ).- U C...I C I 11 Ip I I* a I C C C C C c c C c C c C C c c c c C c C rIi; 1It " . . . . . . . .I * I co = 2 I. I 11 4 - 4 -4 - 4 -4 -4 - 4 -4 - - IW a4 0 4...4. a 2 3S 3 m -c in 03 4 C 2 U 4 U-c Us o z " Co VOZ U . . c~ PU- U Ř C C 1 in O0. ) 34 cc C 1-4 0 =n in " I- C (A 0w 0-4 044 0 0 0 0. U 0 4w h I01 I

  11. 76 FR 34293 - Proposed Collection; Comment Request for Form 1099-C

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... 1099-C AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 1099-C, Cancellation of Debt. DATES: Written comments should be received on or before August 12...

  12. Aryliminopropadienone-C-Amidoketenimine- Amidinoketene-2-Aminoquinolone Cascades and the Ynamine-Isocyanate Reaction.

    PubMed

    Wentrup, Curt; Rao, V. V. Ramana; Frank, Wilhelm; Fulloon, Belinda E.; Moloney, Daniel W. J.; Mosandl, Thomas

    1999-05-14

    Imidoylketenes 11 and oxoketenimines 12 are generated by flash vacuum thermolysis of Meldrum's acid derivatives 9, pyrrolediones 17 and 18, and triazole 19 and are observed by IR spectroscopy. Ketenimine-3-carboxylic acid esters 12a are isolable at room temperature. Ketenes 11 and ketenimines 12 undergo rapid interconversion in the gas phase, and the ketenes cyclize to 4-quinolones 13. When using an amine leaving group in Meldrum's acid derivatives 9c, the major reaction products are aryliminopropadienones, ArN=C=C=C=O (15). The latter react with 1 equiv of nucleophile to produce ketenimines 12 and with 2 equiv to afford malonic acid imide derivatives 16. N-Arylketenimine-C-carboxamides 12c cyclize to quinolones 13c via the transient amidinoketenes 11c at temperatures of 25-40 degrees C. This implies rapid interconversion of ketenes and ketenimines by a 1,3-shift of the dimethylamino group, even at room temperature. This interconversion explains previously poorly understood outcomes of the ynamine-isocyanate reaction. The solvent dependence of the tautomerism of 4-quinolones/4-quinolinols is discussed. Rotational barriers of NMe(2) groups in amidoketenimines 12c and malonioc amides and amidines 16 (24) are reported.

  13. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 21. (VVKR Incorporated-Zymed, Inc.)

    DTIC Science & Technology

    1988-01-01

    COM I -4-4-4-4 -4 - -4 -4 -4-4-4 -4-4 -4 -4 -4-4 1 OON 1 in nin i 11) -4 V 4 4V) -4 -4 4I i 00-4 I -cc 4 Nx -C -c . .4 -f -4-4 C-4 .4 NN C 0.U40 I 444...zzzzzzzzzzzzzzz 0 0 CL I <Ocn IW -4 0) 00 NOOOOOOOCOOOOOOO N -i I - com I r- I-. P -4-4-4-4-4-4-4 00 r- r 1- 0 00 C14 vWmWW00WWWWWWWmWW In 00 Ln r- < I <Om...0 4c,4- -4 (cor 0%4M0 0 (04 ) t-4 4 00)0-3(n4 C’) 0 0 M-34-03- 0 1 COM 1 -000-4-40000000000-4,40000000000 0 -4 0 00000 ae I MO0M’ I 1.- 0 00 P.- 00 0

  14. In Situ Persistence and Migration of Biochar Carbon and Its Impact on Native Carbon Emission in Contrasting Soils under Managed Temperate Pastures.

    PubMed

    Singh, Bhupinder Pal; Fang, Yunying; Boersma, Mark; Collins, Damian; Van Zwieten, Lukas; Macdonald, Lynne M

    2015-01-01

    Pyrogenic carbon (PyC) is an important component of the global soil carbon (C) pool, but its fate, persistence, and loss dynamics in contrasting soils and environments under planted field conditions are poorly understood. To fill this knowledge gap, a 13C-labelled biochar, as a surrogate material for PyC, produced from Eucalyptus saligna by slow pyrolysis (450°C; δ13C -36.7‰) was surface (0-10 cm) applied in C3 dominated temperate pasture systems across Arenosol, Cambisol and Ferralsol. The results show a low proportion of the applied biochar-C mineralised over 12 months in a relatively clay- and C-poor Arenosol (i.e., 2.0% loss via mineralisation), followed by a clay- and C-rich Cambisol (4.6%), and clay-, C- and earthworm-rich Ferralsol (7.0%). The biochar-C mean residence time (MRT), estimated by different models, varied between 44-1079 (Arenosol), 18-172 (Cambisol), and 11-29 (Ferralsol) years, with the shorter MRT estimated by a one-pool exponential and the longer MRT by an infinite-pool power or a two-pool exponential model. The two-pool model was best fitted to biochar-C mineralisation. The biochar-C recovery in the 12-30 cm soil layer varied from between 1.2% (Arenosol), 2.5-2.7% (Cambisol) and 13.8-15.7% (Ferralsol) of the applied biochar-C after 8-12 months. There was a further migration of biochar-C below the 50-cm depth in the Arenosol, as the combined biochar-C recovery in the mineralised pool and soil profile (up to 30 or 50 cm) was 82%, in contrast to 101% in the Cambisol and 104% in the Ferralsol after 12 months. These results indicate that the downward migration of biochar-C was greatest in the Arenosol (cf. Cambisol and Ferralsol). Cumulative CO2-C emission from native soil-plant sources was lower (p <0.10) in the biochar-amended vs. non-amended Ferralsol. This field-based study shows that the downward migration of biochar-C exceeded its loss via mineralisation in the Arenosol and Ferralsol, but not in the Cambisol. It is thus important to understand biochar-soil interactions to maximise long-term biochar C sequestration potential in planted soil systems.

  15. In Situ Persistence and Migration of Biochar Carbon and Its Impact on Native Carbon Emission in Contrasting Soils under Managed Temperate Pastures

    PubMed Central

    Singh, Bhupinder Pal; Fang, Yunying; Boersma, Mark; Collins, Damian; Van Zwieten, Lukas; Macdonald, Lynne M

    2015-01-01

    Pyrogenic carbon (PyC) is an important component of the global soil carbon (C) pool, but its fate, persistence, and loss dynamics in contrasting soils and environments under planted field conditions are poorly understood. To fill this knowledge gap, a 13C-labelled biochar, as a surrogate material for PyC, produced from Eucalyptus saligna by slow pyrolysis (450°C; δ13C -36.7‰) was surface (0−10 cm) applied in C3 dominated temperate pasture systems across Arenosol, Cambisol and Ferralsol. The results show a low proportion of the applied biochar-C mineralised over 12 months in a relatively clay- and C-poor Arenosol (i.e., 2.0% loss via mineralisation), followed by a clay- and C-rich Cambisol (4.6%), and clay-, C- and earthworm-rich Ferralsol (7.0%). The biochar-C mean residence time (MRT), estimated by different models, varied between 44−1079 (Arenosol), 18−172 (Cambisol), and 11−29 (Ferralsol) years, with the shorter MRT estimated by a one-pool exponential and the longer MRT by an infinite-pool power or a two-pool exponential model. The two-pool model was best fitted to biochar-C mineralisation. The biochar-C recovery in the 12−30 cm soil layer varied from between 1.2% (Arenosol), 2.5−2.7% (Cambisol) and 13.8−15.7% (Ferralsol) of the applied biochar-C after 8−12 months. There was a further migration of biochar-C below the 50-cm depth in the Arenosol, as the combined biochar-C recovery in the mineralised pool and soil profile (up to 30 or 50 cm) was 82%, in contrast to 101% in the Cambisol and 104% in the Ferralsol after 12 months. These results indicate that the downward migration of biochar-C was greatest in the Arenosol (cf. Cambisol and Ferralsol). Cumulative CO2-C emission from native soil-plant sources was lower (p <0.10) in the biochar-amended vs. non-amended Ferralsol. This field-based study shows that the downward migration of biochar-C exceeded its loss via mineralisation in the Arenosol and Ferralsol, but not in the Cambisol. It is thus important to understand biochar-soil interactions to maximise long-term biochar C sequestration potential in planted soil systems. PMID:26509506

  16. All Prime Contract Awards by State or Country, Place and Contractor. Part 6. (Alachua, Florida-Winder, Georgia)

    DTIC Science & Technology

    1989-01-01

    0-4 N :: fIilNN N N N NNN N N N- N N N NQ’ C.-1-4 48 2 2 2 2 z z2 22 M 2 2 2 Zof 0-40 It 104 0 44 4 0 N 4L 0) M 8 It 000 filico!I 00 !d x zaW < K 011...1)2-4 -4 < tuN V)M-4 fl.11) ..- 42 1, (0N MM tcOC’)U)00-4mU)2-0 0) 00 0) i1 inC-U)N0) .4 It I N <Cj ifm-4U)’Lnw)(04) ON -44 4t00 0-4-4 -4-4 - 0 0...8217N N 4U-4.-4-4 tUN (UO) M 4-4.--4I-4-4 -4 dUO 0101 UN0I 0-4N00 11.0 0 -4 00000 --4 0 -hC A 0 _4(. 4 (A 000/00(000000() u ( , -0 ., r-at I M -4 4 C f

  17. Deoxygenation of methyl laurate over Ni based catalysts: Influence of supports

    NASA Astrophysics Data System (ADS)

    Xia, Xiaoqiang; Chen, Hui; Bi, Yadong; Hu, Jianli

    2017-10-01

    The use of a series of nickel based catalysts supported over HZSM-5, Al2O3, C and ZrO2 in the deoxygenation of methyl laurate shows that the deoxygenation activity and deoxygenation pathway of nickel based catalysts can be affected by properties of catalysts. In the absence of H2, β-elimination of methyl laurate is the dominant reaction and a small amount of laurate acid is converted into undecane by direct decarboxylation. At the same time, the highly acidic support HZSM-5 gave higher conversion and C11 alkane selectivity. In the presence of H2, Ni/HZSM-5 catalyst showed a significantly high deoxygenation activity, producing 71% alkanes by methyl laurate conversion at 280 °C and 4MPa H2. While as on mildly acidic (Al2O3) and neutral (C) supports, a restricted hydrodeoxygenation activity was achieved but more oxygenate products were yielded. According to the analysis of intermediate product, the deoxygenation reaction of methyl laurate follows three distinct pathways: in the absence of H2, decarboxylation: C11H23COOCH3→C11H23COOH→C11H24; in the presence of H2, decarbonylation: C11H23COOCH3→C11H23COOH→C11H23CHO→C11H24; and hydrodeoxygenation: C11H23COOCH3 →C11H23COOH→C11H23CHO→C12H25OH→C12H26

  18. All Prime Contract Awards by State or Country, Place and Contractor. Part 8. (Anderson, Indiana-Westwego, Louisiana)

    DTIC Science & Technology

    1989-01-01

    I000 11 -4-4.-4 -4 -14 -4 01 -I (0 .4 N N1 1- I(MOO II r- CO (00 0 9 110(0 Coc N- co-) I MM 0ooo w If 1. 103M It U/) II0 CD (0r-. 4) -01 4-4-- 4-4...0((0 I C.-4-4 c 1-4 - - c -4 C -4 -4-I-4.-1-4 .-- 4 -4I C-4 c-4-4-4-4 r--4 -4 Io I M 0U I" (00( 14 ONNc"NN O N ONNNNNNN O i rh "N N NN ON N - 1(0(0 l

  19. Neuropilin 2: Novel Biomarker and Therapeutic Target for Aggressive Prostate Cancer

    DTIC Science & Technology

    2015-09-01

    1 (0.01) 6.11 (0.44) NPR2 1 (0.042) 17.7 (1.56) 1 (0.27) 15.08 (1.99) GROWTH FACTOR RECEPTOR STEMNESS C hIgG Beva c-S EM A c-fu rSE MA 0 0.2 0.4 0.6...peptide (c-furSEMA) or control peptide (c-SEMA). 9 :VEGF c-S EM A c-fu rSE MAA C PC 3-S PC 3-R C4 -2S C4 -2R Rac-active Rac-input VEGF PC3 C4-2

  20. Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers.

    PubMed

    Sakata, Muneyuki; Ishibashi, Kenji; Imai, Masamichi; Wagatsuma, Kei; Ishii, Kenji; Hatano, Kentaro; Ishiwata, Kiichi; Toyohara, Jun

    2017-12-01

    N,N-di-n-propyl-2-[2-(4-[ 11 C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([ 11 C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), which is upregulated in activated microglia in the brain, and may be useful in positron emission tomography (PET). We examined the safety, radiation dosimetry, and initial brain imaging with [ 11 C]CB184 in healthy human volunteers. Dynamic [ 11 C]CB184 PET scans (90 min) were performed in five healthy male subjects. During the scan, arterial blood was sampled at various time intervals, and the fraction of the parent compound in plasma was determined with high-performance liquid chromatography. No serious adverse events occurred in any of the subjects throughout the study period. [ 11 C]CB184 was metabolized in the periphery: 36.7% ± 5.7% of the radioactivity in plasma was detected as the unchanged form after 60 min. The total distribution volume (V T ) was estimated with a two-tissue compartment model. The V T of [ 11 C]CB184 was highest in the thalamus (5.1 ± 0.4), followed by the cerebellar cortex (4.4 ± 0.2), and others. Although regional differences were small, the observed [ 11 C]CB184 binding pattern was consistent with the TSPO distribution in the normal human brain. Radiation dosimetry was determined in three healthy male subjects using a serial whole-body PET scan acquired over 2 h after [ 11 C]CB184 injection. [ 11 C]CB184 PET demonstrated high uptake in the gallbladder at a later time (>60 min). In urine obtained approximately 100 min post-injection, 0.3% of the total injected radioactivity was recovered, indicating hepatobiliary excretion of radioactivity. The absorbed dose (μGy/MBq) was highest in the kidneys (21.0 ± 0.5) followed by the lungs (16.8 ± 2.7), spleen (16.6 ± 6.6), and pancreas (16.5 ± 2.2). The estimated effective dose for [ 11 C]CB184 was 5.9 ± 0.6 μSv/MBq. This initial evaluation indicated that [ 11 C]CB184 is feasible for imaging of TSPO in the brain.

  1. Investigation of the Effect of Low Level Maritime Haze on DMSP VHR and LF Imagery.

    DTIC Science & Technology

    1980-09-09

    LA S LO i-4 CNJ 0) r m~X LA3 crj (N > Co -i s- - -I CN r -~ 4J. 4-4 C) 4-) >1 Cl) 0H 9 -r-( Nl NV C 0 MN (1)0 r4 s-4 L 4-)4 Uv) Cu...be approximated as : 5-12 o 0 LA r40 oD (n rn N .4 .-4 0 C14.. LA Ln LA N- 0N 0C) LA 4 . l4-) r-. LA en C4 N . 049 0 1 E-4~ . (1 0 .t 0 ’p .r LA LA LA ...w CN C1 04 .00 C4.) r -4 O N~ ’. r - CA a ’.0 LA w m~ N1 Q4-1 Ř .4.4 Q) I- Q) in - r-4 O 4 1d𔃺 -4 0 0 4J *-0 0~

  2. Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

    PubMed

    Borthwick, A D; Evans, D N; Kirk, B E; Biggadike, K; Exall, A M; Youds, P; Roberts, S M; Knight, D J; Coates, J A

    1990-01-01

    The racemic carbocyclic 2'-fluoroarabinosyl pyrimidine nucleosides 8, 9 (C-FIAU), 12, and 13 (C-FMAU) and the 2'-fluororibosyl pyrimidine nucleosides 17, 20, and 21 were prepared from their respective protected 2'-fluoro amino diols 5 and 14. The carbocyclic 2'-2'-difluorothymidine analogue 27 was obtained from the protected difluoro amino diol 24 which was prepared from the ketone 23 and (diethylamino)sulfur trifluoride (DAST). The chiral carbocyclic 2'-deoxy-6'-fluorouridines 33, 34, 38, and 39 were synthesized from the protected 6'-fluoro amino diols 30 and 36, which were prepared by reduction of the azides 28 and 35. C-FMAU (13) and C-FIAU (9) were active in vitro against HSV-1 with ID50 values of 4.4 and 11 micrograms/mL, respectively, but they were inactive against HSV-2. The cytidine analogues 12 and 20 displayed modest activity in vitro against HSV-1 and HSV-2 but were inactive against human influenza A virus.

  3. Prime Contract Awards by State or Country, Place and Contractor. Part 11 (Gibbsboro Air Force Station, New Jersey - Peekskill, New York), FY1991

    DTIC Science & Technology

    1991-01-01

    MO enC mC mmOmm CIS m 4’ ’)04 I.0 -0 -o 4 -0 00 00 00 0> o * I (CI)0 W ro- 141-1 Il--- w441- 11- 4.1- t4-- - 441r-1- UII- 1- 41 ~ IS 0 4400 to 1- r...it EM’N-4-4m’-I-IN ENc , EN ENc EON E -4 E --- Ec’) E-1 toI -4 M- 04 I C’(000)’)r-q 0-0 ON 000 O-4in 000 O0 0 I 0-4 Ofr-- 0 Ki C.. 04 K 1000-0 V)0 (n 00...C--(0c’ 01" CI w .I. 10 .4 I 02-4 Nf (Ion (0 W((0(u’)-4mww -z0 > 03 II-4 1I 02-4 If Z-I 4 W-1)IN(N"r-000C’) w0 o Nf 𔃺 1 M2-4 N" W-S LaDO -4-4 -4 4 4

  4. Theoretical study on elastic properties of Si2N2O by ab initio calculation

    NASA Astrophysics Data System (ADS)

    Tsuboi, Seiya; Adachi, Kanta; Nagakubo, Akira; Ogi, Hirotsugu

    2018-07-01

    The elastic constants of crystalline Si2N2O remain unknown since it was discovered in the 1960s. We determine the nine independent elastic constants of orthorhombic Si2N2O by ab initio calculations. We applied various deformation modes with strains up to ±0.01 to a unit cell, calculated the energy-strain relationships, and deduced all the elastic constants by fitting the harmonic-oscillation function. Our results are as follows: C 11 = 311.1, C 22 = 238.5, C 33 = 317.9, C 44 = 136.1, C 55 = 57.6, C 66 = 73.9, C 12 = 79.6, C 13 = 52.2, and C 23 = 33.6 GPa. Despite the different crystal structures and symmetries, the direction-over-averaged Young’s modulus of Si2N2O is well explained by the nitrogen content and Young’s moduli of α-SiO2 and β-Si3N4. The anisotropy of sound-wave velocity was investigated, and its origin was examined on the basis of the crystallographic structure. The quasi-isotropic plane for the longitudinal-wave propagation was identified.

  5. Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis.

    PubMed

    Yu, Zhaoxiao; Zhang, Chenhui; Zhou, Mingliang; Li, Qiming; Li, Hui; Duan, Wei; Li, Xue; Feng, Yonghong; Xie, Jianping

    2017-09-01

    Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a formidable threat to global public health. The successful intracellular persistence of M. tuberculosis significantly contributes to the intractability of tuberculosis. Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are mycobacterial exclusive protein families that widely reported to be involved in the bacterial virulence, physiology and interaction with host. Rv2770c (PPE44), a predicted virulence factor, was up-regulated upon the infected guinea pig lungs. To investigate the role of Rv2770c, we heterologously expressed the PPE44 in the nonpathogenic fast-growing M. smegmatis strain. Subcellular location analysis demonstrated that Rv2770c is a cell wall associated protein, suggestive of a potential candidate involved in host-pathogen interaction. The Rv2770c can enhance M. smegmatis survival within macrophages and under stresses such as H 2 O 2 , SDS, diamide exposure, and low pH condition. M. smegmatis expressing Rv2770c is more virulent as testified by the increased death of macrophages and the increased expression of interlukin-6 (IL-6) and interlukin-12p40 (IL-12p40). Moreover, Rv2770c altered the secretion of IL-6 and IL-12p40 of macrophages via NF-κB, ERK1/2 and p38 MAPK axis. Taken together, this study implicated that Rv2770c was a virulent factor actively engaged in the interaction with host macrophage. Copyright © 2017. Published by Elsevier B.V.

  6. Technical Papers Presented at the Defense Nuclear Agency Global Effects Review - 7-9 April 1987. Volume 1

    DTIC Science & Technology

    1987-04-30

    El C4E)0 0W:C 1 (D ~ ~ ~ ~ ~ IN C D mMc/i 44- c C-4 v- en q 44 C; 4 n 0- z ! -L Ch4, mO M 0 0 0 m 0o 0o x IN >zW 4 4 . U L 4U 0 UL...wTwA~ Fl Fu~~wjr wjilwvK~l.Wvv 0l 000 Ll.I 0 0 4- LL 4- &n G) CL&.I 0 a C4 -j N 0A- 4- La - E 0. 0 S- If 0 0 C LO EF *( . S Eu IL EEuS-t S-to) en ...002.5W 5 /8 1 .0 C=1000 0.8 C=300 ~0.6 C-) 00 0 00030405 VETCL EOIY)msc La .. N378 1 1 1115(f i 0.2 I11 Su INTERSTITIAL SMOKE (g/cm**3) 60 min 7 6 5 EN

  7. COPPERHEAD Operational Performance Evaluation (COPE): Computer Program User and Analyst Manual.

    DTIC Science & Technology

    1981-03-01

    I - ft N C * % S C.󈧬 4 ft - 2 4 4 0. 44 ft 2 -J 𔃾- OIl . ft...C CDD)( A - 4 I < 4- 0 C) C LUV ) I < C)(. I -L =L I - >C) =~ LU;- CU "-. I -7 CiWC n Li u <E m C) mw. vi tl <LU ~J 0- C-W CI- CD C)0 Li0 ( 0 C-j C- Li w...creating a new TAPL II; when PREPMS is modifying an 14-1 Initlaii..-eand uperl f i 1,- oil TAPE 11 ,L ,, Ittempt to read Print "Creation Run" Pj_, N P C

  8. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Goodells Michigan - Warrenton Missouri)

    DTIC Science & Technology

    1993-01-01

    q -f-i o0-1-4 -t- IM. 0,11(14o0 M0000-4 it 0000 o 474I 40)m0) 0 00C(1~ (.0 0 -4"( m m 420 co0m) 0(D (D 0 44200 44 400 44M 000 C)C -4 -1 4 -- 4 0, - 0...N : 44200 0 at 0.4 1- V0 0i Ix 0- 001 40 L0 0- 0 0)N01 c H4 , M0oN " #O--) "-,)I-- 0:3 00 0 0 1- -1 01 - "-4 2> >- Ct0 00-D-- -114 0 1 £0ON 44 444<ɚ

  9. A two-dimensional Zn coordination polymer with a three-dimensional supra-molecular architecture.

    PubMed

    Liu, Fuhong; Ding, Yan; Li, Qiuyu; Zhang, Liping

    2017-10-01

    The title compound, poly[bis-{μ 2 -4,4'-bis-[(1,2,4-triazol-1-yl)meth-yl]biphenyl-κ 2 N 4 : N 4' }bis-(nitrato-κ O )zinc(II)], [Zn(NO 3 ) 2 (C 18 H 16 N 6 ) 2 ] n , is a two-dimensional zinc coordination polymer constructed from 4,4'-bis-[(1 H -1,2,4-triazol-1-yl)meth-yl]-1,1'-biphenyl units. It was synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Zn II cation is located on an inversion centre and is coordinated by two O atoms from two symmetry-related nitrate groups and four N atoms from four symmetry-related 4,4'-bis-[(1 H -1,2,4-triazol-1-yl)meth-yl]-1,1'-biphenyl ligands, forming a distorted octa-hedral {ZnN 4 O 2 } coordination geometry. The linear 4,4'-bis-[(1 H -1,2,4-triazol-1-yl)meth-yl]-1,1'-biphenyl ligand links two Zn II cations, generating two-dimensional layers parallel to the crystallographic (132) plane. The parallel layers are connected by C-H⋯O, C-H⋯N, C-H⋯π and π-π stacking inter-actions, resulting in a three-dimensional supra-molecular architecture.

  10. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 10 (Hi Plains Supply - International Cnslt Eng Inc).

    DTIC Science & Technology

    1985-01-01

    cccC’-4.4 J-4-4 0,30----44.4f. w I(0 .41 -0)0000000 (00000 0)0 0)0)00000000 0ɘ (0(0c, f6 (0 .4ICCCCC ACC 1 ococo w w Wc co 0 000 000 n o00000 0 o...W00O00000000 woo0 INNC 1(0 .41200000000 200000 zoo 200000000000 2000 2WW F.- Im "W ww ww 11C(UCAAAA -4U)nCh cnAA(A 0-4IACA C ACCA ACCWj IC(nC (n -4<< o󈧎

  11. 75 FR 44047 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... 05/01/19 07-06-C-01-SUN Haily, ID 06/02/10 691,368 763,226 11/01/10 12/01/10 04-07-C-03-JNU Juneau, AK 06/03/10 5,226,106 3,566,606 09/01/08 03/01/08 07-07-C-01-ALO Waterloo, IA 06/14/10 356,706 363,977 03/01/11 03/01/11 09-14-C-01-MRY Monterey, CA 06/21/10 854,823 980,026 08/01/10 12/01/10 07-11-C...

  12. U. S. Civil Airmen Statistics.

    DTIC Science & Technology

    1976-01-01

    25, 44 9 , 2 ,2 Sa 27 , ’ n Ci Un C ted Sta ten”total , 3OIL.J038 U35,V,3,91 l,,s.4_ ‘.4 11.7 ‘n,,’iJ~, U.L,,i2 ~~~~ ~~~~~ New Eo g l a n d .— t...Me xiCo 1 ,717 88S 78 (401 (2 9 5 5 3 V s Arkansas 5 ,666 865 61 (425 5 “ C S 9 CC R ocky Mou flt wun .”total - - ‘ L,1iI 0.019 53~, la,12n4

  13. Clinical features of patients with homozygous complement C4A or C4B deficiency.

    PubMed

    Liesmaa, Inka; Paakkanen, Riitta; Järvinen, Asko; Valtonen, Ville; Lokki, Marja-Liisa

    2018-01-01

    Homozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex. There are no studies where the clinical presentation of these patients is analyzed. This study was aimed to characterize the clinical features of patients with homozygous C4A or C4B deficiency. Thirty-two patients with no functional C4A, 87 patients with no C4B and 120 with normal amount of C4 genes were included. C4A and C4B numbers were assessed with genomic quantitative real-time PCR. Medical history was studied retrospectively from patients' files. Novel associations between homozygous C4A deficiency and lymphoma, coeliac disease and sarcoidosis were detected. These conditions were present in 12.5%, (4/32 in patients vs. 0.8%, 1/120, in controls, OR = 17.00, 95%CI = 1.83-158.04, p = 0.007), 12.5% (4/32 in patients vs. 0%, 0/120 in controls, OR = 1.14, 95%CI = 1.00-1.30, p = 0.002) and 12.5%, respectively (4/32 in patients vs. 2.5%, 3/120 in controls, OR = 5.571, 95%CI = 1.79-2.32, p = 0.036). In addition, C4A and C4B deficiencies were both associated with adverse drug reactions leading to drug discontinuation (34.4%, 11/32 in C4A-deficient patients vs. 14.2%, 17/120 in controls, OR = 3.174, 95%CI = 1.30-7.74, p = 0.009 and 28.7%, 25/87 in C4B-deficient patients, OR = 2.44, 95%CI = 1.22-4.88, p = 0.010). This reported cohort of homozygous deficiencies of C4A or C4B suggests that C4 deficiencies may have various unrecorded disease associations. C4 gene should be considered as a candidate gene in studying these selected disease associations.

  14. Microstructure, microstructural stability and mechanical properties of sand-cast Mg–4Al–4RE alloy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rzychoń, Tomasz, E-mail: tomasz.rzychon@polsl.pl; Kiełbus, Andrzej; Lityńska-Dobrzyńska, Lidia

    2013-09-15

    This paper presents a methodology for assessing the phase composition and the results of structural stability tests of the sand-cast Mg–4Al–4RE alloy after annealing it at 175 and 250 °C for 3000 h. The microstructure was analyzed with optical, scanning electron, and transmission electron microscopy. The phase composition was determined with X-ray diffraction. The structure of the Mg–4Al–4RE (AE44) alloy is composed of large grains of α-Mg solid solution, needle-shaped precipitates of the Al{sub 11}RE{sub 3}phase, polyhedral precipitates of the Al{sub 2}RE phase and Al{sub 10}RE{sub 2}Mn{sub 7} phase. After annealing at 175 °C for 3000 h, no changes inmore » the alloy structure are observed, whereas after annealing at 250 °C the precipitates of the Al{sub 11}RE{sub 3} phase are found to be in the initial stages of spheroidization. The coarse-grained structure and unfavorable morphology of the intermetallic phases in the sand-cast AE44 alloy, which are caused by low solidification rates, result in low creep resistance up to 200 °C and low mechanical properties at ambient temperature and at 175 °C. - Highlights: • Complement the knowledge about the microstructure of Mg-Al-RE alloys. • Clarify the mechanism of formation of Mg17Al12 phase above 180 °C. • Applying a chemical dissolution of the α-Mg in order to phase identification. • Applying a statistical test to assess the spheroidization of precipitates. • Quantitative description of microstructure of Mg-Al-RE alloys.« less

  15. Report of the Defense Science Board Task Force on Year 2000.

    DTIC Science & Technology

    1998-04-01

    Reagan 11:45 ASD (C3I) Mr. Tony Valletta , Acting ASDfC3!) 12:15 Lunch 12:45 Patriot Mr. Dean Mullis 1:45 F-15E Col Richard Bowman, F-15 Program...Financial Operations, Logistics, Transportation Adjourn Mr. Tony Valletta , Acting ASDfC31) Mr. Tom Backman Mr. Jack Winters Col Rounce and Maj...Coffee/ Tea 8:30 Chairman’s time 9:00 Task Force Discussions 10:15 C3I Update Tony Valletta , Actg. ASDfC3!) 11:00 J-6V 11:45 Lunch 12:15 Navy E

  16. Cross section asymmetry of two-body carbon disintegration 12C (γ , p)11B with polarized photons at energy 40-50 MeV

    NASA Astrophysics Data System (ADS)

    Burdeinyi, D.; Brudvik, J.; Fissum, K.; Ganenko, V.; Hansen, K.; Isaksson, L.; Livingston, K.; Lundin, M.; Nilsson, B.; Schroder, B.

    2017-01-01

    The cross section asymmetry of 12C (γ ,p01)11B and 12C (γ ,p2-6)11B reactions has been studied at the energy range 40-55 MeV, using linearly polarized tagged photons of the MAX-lab facility. The asymmetry of the 12C (γ ,p01)11B processes, which assume the one-body mechanism of the reaction, is Σ ≈ 0.82 ± 0.05 for photon energies 45-50 MeV. The asymmetry for the 12C (γ ,p2-6)11B reactions, which produce a maximum at excitation energy ∼ 6 MeV, is Σ ≈ 0.53 ± 0.13 for a photon energy 49 MeV. It is close to the asymmetry of reaction of the free deuteron photodisintegration, and can be resulted from the two-body mechanism of the photon absorption.

  17. Clinical, biochemical and molecular characterization of cystinuria in a cohort of 12 patients.

    PubMed

    Barbosa, M; Lopes, A; Mota, C; Martins, E; Oliveira, J; Alves, S; De Bonis, P; Mota, M do Céu; Dias, C; Rodrigues-Santos, P; Fortuna, A M; Quelhas, D; Lacerda, L; Bisceglia, L; Cardoso, M L

    2012-01-01

    Cystinuria is a rare autosomal inherited disorder characterized by impaired transport of cystine and dibasic aminoacids in the proximal renal tubule. Classically, cystinuria is classified as type I (silent heterozygotes) and non-type I (heterozygotes with urinary hyperexcretion of cystine). Molecularly, cystinuria is classified as type A (mutations on SLC3A1 gene) and type B (mutations on SLC7A9 gene). The goal of this study is to provide a comprehensive clinical, biochemical and molecular characterization of a cohort of 12 Portuguese patients affected with cystinuria in order to provide insight into genotype-phenotype correlations. We describe seven type I and five non-type I patients. Regarding the molecular classification, seven patients were type A and five were type B. In SLC3A1 gene, two large genomic rearrangements and 13 sequence variants, including four new variants c.611-2A>C; c.1136+44G>A; c.1597T (p.Y533N); c.*70A>G, were found. One large genomic rearrangement was found in SLC7A9 gene as well as 24 sequence variants including 3 novel variants: c.216C>T (p.C72C), c.1119G>A (p.S373S) and c.*82C>T. In our cohort the most frequent pathogenic mutations were: large rearrangements (33.3% of mutant alleles) and a missense mutation c.1400T>C (p.M467T) (11.1%). This report expands the spectrum of SLC3A1 and SLC7A9 mutations and provides guidance in the clinical implementation of molecular assays in routine genetic counseling of Portuguese patients affected with cystinuria. © 2011 John Wiley & Sons A/S.

  18. User Requirements Analyzer (URA) User’s Manual H6180/Multics/Version 3.3.

    DTIC Science & Technology

    1978-07-01

    4.3 Enterinq Data Into An Input File 11 4.4 Using NAME- GEN 11 4.5 Using PUNCH Files 12 5. Receiving Output From URA Commands 12 5.1 The...CONSISTENCY RBPOPT 2fc^ KWIC INDEX 27? LIST-CHANGES Report 276 NAME- GEN 28C NAME LIST 29? PICTURE 313 PROCESS CHAIN...428 FREQUENCY U32 HELP U33 INPUT-PSL 434 INTERVAL-CONSISTENCY 435 KWIC 436 LIST-CtlANGES 437 N Af.E- GEN 4 38 NAf’B-LIST

  19. 11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.

    PubMed

    Franzese, Ciro; Lopci, Egesta; Di Brina, Lucia; D'Agostino, Giuseppe Roberto; Navarria, Pierina; Mancosu, Pietro; Tomatis, Stefano; Chiti, Arturo; Scorsetti, Marta

    2017-10-21

    aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases. patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed. twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%). SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

  20. Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place. Part 3. (Ferrelli, Tony-Karl Arason)

    DTIC Science & Technology

    1989-01-01

    V)(0 r-0C -4- f6 04 -4 -4 r- - Nc’J(jC1 l I.- I i i -r I c a( cr I 1- I (’)C -MU 0 ~ (’ 00 m(0(00 0 0> 11-0i 1 .4 to 040 m go 0 a -4O 0)0 (1\\IN ) 0...00~-40 (0 0<I~~ : (0(0 00-%~ o* m o m ww rr 0 " " II- Q4 Of. w~ U1-U)4w 4 -4 0m -el4-4 - m R U)I 4-4 -I g t>1c 0) Acca ) 0) m (0(cE 0 IV( 0 a 0) Ol’ 1

  1. 1984 CRC (Coordinating Research Council) Octane Number Requirement Survey.

    DTIC Science & Technology

    1985-12-01

    Knocking IAE 230A3/LAE 230A3 14 13 5 38.5 (Knock Sensor, Max. [high]) NAR F25A3/HAR F25A3/ IAR F25A3/LAR F25A3 12 11 8 72.7 NAX 228A3/HAX 228A3 13 10 6...102 -- 14 86 91.4 10.6 103 -- 5 95 92.6 10.4 7 C- 3 TABLE C-111 -" - 44. SENSITIVITIES OF 1984 AND 1983 FBRU AND FBRSU FUELS FBRU FBRSJ Research...c CA LA V) - I- 00 co =I CJ 9 Lo a, INN wo. I"L co 0 I- J o󈧄A ON m ~ al c m M. CDj CDa *l 14 00 1 I0 ff Ln tD1 00 ON Q𔃾.036 P-04 -, LOJ L- %% W D m

  2. 40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

  3. 40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

  4. 40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

  5. 40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

  6. 40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

  7. Calorimetric Study of Phase Transitions Involving Twist-Grain-Boundary TGB{A} and TGB{C} Phases

    NASA Astrophysics Data System (ADS)

    Navailles, L.; Garland, C. W.; Nguyen, H. T.

    1996-09-01

    High-resolution calorimetry has been used to determine the heat capacity and latent heat associated with phase transitions in the homologous series of chiral liquid crystals nF_2BTFO_1M_7 [ 3-fluoro-4(1-methylheptyloxy)4'-(4''-alkoxy-2'', 3''-difluorobenzoyloxy)tolane] . These compounds exhibit smectic-C^* (SmC^*), twist-grain-boundary (TGBA for n=10, TGBC for n=11, 12) and cholesteric (N^*) phases. All the phase transitions are first order with small to moderate latent heats. There is a large rounded excess heat capacity peak in the N^* phase that is consistent with the predicted appearance of short-range TGB order (chiral line liquid character). This is analogous to the development of an Abrikosov flux vortex liquid in type-II superconductors. Both the n=11 and 12 homologs exhibit two closely spaced transitions in the region where a single TGBC - N^* transition was expected. This suggests the existence of two thermodynamically distinct TGBC phases. Des exprériences de calorimétrie haute résolution ont été réalisées pour déterminer les chaleurs spécifiques et les chaleurs latentes associées aux transitions de phase des homologues de la série crystal liquide nF_2BTFO_1M_7: 3-fluoro-4[1-methyl-heptyloxy]4'-(4''-alcoxy-2'', 3''-difluorobenzoyloxy)tolanes. Ces produits présentent la phase smectique C^* (SmC^*), les phases à torsion par joint de grain (TGBA pour n=10 et TGBC pour n=11, 12) et la phase cholestérique (N^*). Toutes les transitions de phase sont du premier ordre. La chaleur latente associée à ces transitions est faibles ou modérée. Nous observons, dans la phase N^*, un grand pic arrondi qui est en accord avec les prédictions de l'apparition d'un ordre TGB à courte distance (liquide de ligne de dislocation). Ce phénomène est l'analogue du liquide de vortex dans les supraconducteurs de type II. Les composés n=11 et 12 présentent, dans la région où nous attendions une transition TGBC - N^* unique, deux transitions sur un très faible domaine de température. Ce résultat suggère l'existence de deux phases TGBC thermodynamiquement distinctes.

  8. Functional lipids based on [12]aneN3 and naphthalimide as efficient non-viral gene vectors.

    PubMed

    Gao, Yong-Guang; Alam, Uzair; Tang, Quan; Shi, You-Di; Zhang, Ying; Wang, Ruibing; Lu, Zhong-Lin

    2016-07-14

    Small organic non-viral gene vectors with the structural combinations of (aliphatic chain)-naphthalimide-[12]aneN3 (11a, b) and naphthalimide-(aliphatic chain)-[12]aneN3 (12a-c) were synthesized and fully characterized. Agarose gel electrophoresis experiments indicated that the first type of compounds, 11a and 11b, could completely retard DNA at the concentration of 5 μM in the presence of DOPE. Within the second type of compounds, 12c with the decane chain showed a complete retardation of DNA at the concentration of 20 μM, whereas 12a and 12b with the ethyl and hexyl chains could not retard DNA effectively. Dynamic light scattering measurements indicated that compounds 11a, 11b and 12b, 12c condensed DNA into nanoparticles with the size in the range of 60-160 nm. Due to the strong fluorescence of 11a and 11b, the distribution of lipids/DNA complexes and the process of DNA release from the lipids were clearly observed via cellular uptake experiments. On the other hand, the non-fluorescent 12a-c enabled the EB exclusion assay to afford the binding constants of 4.88 × 10(6) M(-1) (12a), 4.18 × 10(6) M(-1) (12b) and 3.39 × 10(6) M(-1) (12c), respectively. The MTT assay revealed that both types of compounds have low cytotoxicity. Non-fluorescent 12c was successfully applied in the eGFP expression experiments in A549 cells and showed stronger green fluorescence emission than that of lipofectamine 2000. Quantitative transfection experiments through the luciferase assay further revealed that compounds 11a, 11b and 12c can act as non-viral gene vectors in different cell lines. Among them, 12c gave the highest transfection efficiency in HeLa cells, which was about 2 times that offered by lipofectamine 2000. This work clearly demonstrated that the right combination of different functional units and long aliphatic linkers will likely promote gene delivery and transfection efficiency.

  9. Temperature-dependent elasticity of Pb [(Mg0.33Nb0.67 ) 1 -xT ix ] O3

    NASA Astrophysics Data System (ADS)

    Tennakoon, Sumudu; Gladden, Joseph; Mookherjee, Mainak; Besara, Tiglet; Siegrist, Theo

    2017-10-01

    Relaxor ferroelectric materials, such as Pb [(Mg0.33Nb0.67 ) 1 -xT ix ] O3 (PMN-PT) with generic stoichiometry, undergo a ferroelectric-to-paraelectric phase transition as a function of temperature. The exact transition characterized by Curie temperature (Tc) varies as a function of chemistry (x ), i.e., the concentration of Ti. In this study, we investigated the structural phase transition by exploring the temperature dependence of the single-crystal elastic properties of Pb [(Mg0.33Nb0.67 ) 0.7T i0.3 ] O3 , i.e., x ≈0.3 . We used resonant ultrasound spectroscopy to determine the elasticity at elevated temperatures, from which Tc=398 ±5 K for PMN-PT (x ≈0.3 ) was determined. We report the full elastic constant tensor (Ci j={ C11,C12,C44 }), acoustic attenuation (Q-1), longitudinal (VP) and shear (VS) sound velocities, and elastic anisotropy of PMN-PT as a function of temperature for 400 Tc the material first stiffens and reaches maxima in the vicinity of the Burns temperature (Tb˜673 K ), followed by a more typical gradual softening of the elastic constants. Similar temperature-dependent anomalies are also observed with anisotropy and Q-1, with minima in the vicinity of Tb. We used the temperature dependence of Ci j, Q-1, VP,VS , and anisotropy to infer the evolution of polar nanoregions as the material evolved from T >Tc .

  10. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 11. (Kalidescope Shipping, Inc.-Lous Electronics)

    DTIC Science & Technology

    1989-01-01

    0 ( 0 - ( 0 q I - 0 5 0 ) I WOON It -4Z r-44- 5 -N40 142 it I COC of 0I I 000 H9 is :i mo 000 111.~-D~ 0 : It -L -4 moo -4 - C I) N-4...LA 0 0 ɜif IN " 0 1- 0 2 0 LAI 0 0 1- w 1- 2 1-- 1 : I N 11 5 -4 ൾ w c-c M 1.- 0 0 c < Xf. 0 )112E I) D0 01 01 U) Q 0 ) C 0 0 -~ 0 f- i- w 11 z I) iia...8217),- N m - 0 ( 0

  11. Microcomputer Based Ship-Board Gun Control System.

    DTIC Science & Technology

    1981-03-01

    to0 CD 04 5. 6D3. bi t0 U3 3 3. A - a U3 vi4 . * ~ ~ ~ 1 z.. n . 0 4 OR *4 AnS 94 C.) 0 3 * 04 td ) . cu 4. P* 0r * 3 6* 04 to 0 f 3. 4 6-4 "a I c *0...0I td ..M U o -Oq I Z ) OM Pm , N ou POO 0 -4 I h 4 * W33 SVil lot I 4- ad2 13 41 *f 0 44 ac ci 0 IH 4n 0= U 04 o3 0, 3a V). cav% n oft af 44 0 A4A... td ) -zl- ~ 6N 0 l 4 44L CdP 9 ~CI (n l 4 t3 0. .4 vi~ n - 4 U :A -. c 14 w i cn v - V", v- C) 4A " =- " cL c. Ni 0.4 (n Z m a -I 11) Cd E4 r a. a

  12. Rapid and Easy Identification of Capsular Serotypes of Streptococcus pneumoniae by Use of Fragment Analysis by Automated Fluorescence-Based Capillary Electrophoresis

    PubMed Central

    Selva, Laura; del Amo, Eva; Brotons, Pedro

    2012-01-01

    The purpose of this study was to develop a high-throughput method for the identification of pneumococcal capsular types. Multiplex PCR combined with fragment analysis and automated fluorescent capillary electrophoresis (FAF-mPCR) was utilized. FAF-mPCR was composed of only 3 PCRs for the specific detection of serotypes 1, 2, 3, 4, 5, 6A/6B, 6C, 7F/7A, 7C/(7B/40), 8, 9V/9A, 9N/9L, 10A, 10F/(10C/33C), 11A/11D/11F, 12F/(12A/44/46), 13, 14, 15A/15F, 15B/15C, 16F, 17F, 18/(18A/18B/18C/18F), 19A, 19F, 20, 21, 22F/22A, 23A, 23B, 23F, 24/(24A/24B/24F), 31, 33F/(33A/37), 34, 35A/(35C/42), 35B, 35F/47F, 38/25F, and 39. In order to evaluate the assay, all invasive pneumococcal isolates (n = 394) characterized at Hospital Sant Joan de Déu, Barcelona, Spain, from July 2010 to July 2011 were included in this study. The Wallace coefficient was used to evaluate the overall agreement between two typing methods (Quellung reaction versus FAF-mPCR). A high concordance with Quellung was found: 97.2% (383/394) of samples. The Wallace coefficient was 0.981 (range, 0.965 to 0.997). Only 11 results were discordant with the Quellung reaction. However, latex reaction and Quellung results of the second reference laboratory agreed with FAF-mPCR for 9 of these 11 strains (82%). Therefore, we considered that only 2 of 394 strains (0.5%) were not properly characterized by the new assay. The automation of the process allowed the typing of 30 isolates in a few hours with a lower cost than that of the Quellung reaction. These results indicate that FAF-mPCR is a good method to determine the capsular serotype of Streptococcus pneumoniae. PMID:22875895

  13. ¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men.

    PubMed

    Luoto, Pauliina; Suilamo, Sami; Oikonen, Vesa; Arponen, Eveliina; Helin, Semi; Herttuainen, Jukka; Hietamäki, Johanna; Holopainen, Aila; Kailajärvi, Marita; Peltonen, Juha M; Rouru, Juha; Sallinen, Jukka; Scheinin, Mika; Virta, Jere; Virtanen, Kirsi; Volanen, Iina; Roivainen, Anne; Rinne, Juha O

    2014-10-01

    (11)C-labelled 1-[(S)-1-(2,3-dihydrobenzo[1,2]dioxin-2-yl)methyl]-4-(3-methoxy-methylpyridin-2-yl)-piperazine ((11)C-ORM-13070) is a novel PET tracer for imaging of α2C-adrenoceptors in the human brain. Brain α2C-adrenoceptors may be therapeutic targets in several neuropsychiatric disorders, including depression, schizophrenia and Alzheimer's disease. To validate the use of (11)C-ORM-13070 in humans, we investigated its radiometabolism, pharmacokinetics, whole-body distribution and radiation dose. Radiometabolism was studied in a test-retest setting in six healthy men. After intravenous injection of (11)C-ORM-13070, blood samples were drawn over 60 min. Plasma samples were analysed by radio-HPLC for intact tracer and its radioactive metabolites. Metabolite-corrected plasma time-activity curves were used for calculation of pharmacokinetics. In a separate group of 12 healthy men, the whole-body distribution of (11)C-ORM-13070 and radiation exposure were investigated by dynamic PET/CT imaging without blood sampling. Two radioactive metabolites of (11)C-ORM-13070 were detected in human arterial plasma. The proportion of unchanged (11)C-ORM-13070 decreased from 81 ± 4 % of total radioactivity at 4 min after tracer injection to 23 ± 4 % at 60 min. At least one of the radioactive metabolites penetrated into red blood cells, while the parent tracer remained in plasma. The apparent elimination rate constant and corresponding half-life of unchanged (11)C-ORM-13070 in arterial plasma were 0.0117 ± 0.0056 min(-1) and 73.6 ± 35.8 min, respectively. The organs with the highest absorbed doses were the liver (12 μSv/MBq), gallbladder wall (12 μSv/MBq) and pancreas (9.1 μSv/MBq). The mean effective dose was 3.9 μSv/MBq, with a range of 3.6 - 4.2 μSv/MBq. (11)C-ORM-13070 was rapidly metabolized in human subjects after intravenous injection. The effective radiation dose of (11)C-ORM-13070 was in the same range as that of other (11)C-labelled brain receptor tracers. An injection of 500 MBq of (11)C-ORM-13070 would expose a subject to 2.0 mSv of radiation. This supports the use of (11)C-ORM-13070 in repeated PET scans, for example, in receptor occupancy trials with novel drug candidates.

  14. Replacement of MDA with more oxidatively stable diamines in PMR-polyimides

    NASA Technical Reports Server (NTRS)

    Alston, W. B.

    1985-01-01

    Studies are performed to investigate the effect of substituting 4,4'-oxydianiline and 1,1-bis(4-aminophenyl)-1-phenyl-2,2,2-trifluoroethane for the 4,4'-methylenedianiline in PMR polyimide matrix resin. Graphite fiber reinforced composites are fabricated from unsized Celion 6000 and PMR-polyimide matrix resins having formulated molecular weights in the range of 1500 to 2400. The composite processing characteristics are investigated and the initial room temperature and 316 C (600 F) composite mechanical properties are determined. Comparative 316 C composite weight losses and 316 C mechanical properties retention after prolonged 316 C air exposure are also determined.

  15. [Influence of conjugated linoleic acids on metabolic processes in cells and tissues].

    PubMed

    Siwiec, Ewa; Stachowska, Ewa

    2017-01-01

    Conjugated linoleic acids (CLA) are constitutional and geometric isomers of this acid. The most commonly consumed geometric isomers are cis-9,trans-11 (c9, t11) CLA and trans-10, cis-12 (t10,c12) CLA. These isomers together with trans-9,trans-11 CLA and trans-10,trans-12 CLA constitute about 90% of all CLA in natural products. Different structure of the isomers affects their functions in the body. Differences in the effects on organs and tissues are sometimes small and sometimes opposed, sometimes the isomers work synergistically. Diverse influence has been shown mainly in neoplastic processes and lipid metabolism. For example, differences in inhibition of proliferation of prostate cancer cells are explained by different pathways: t10,c12 CLA acts on apoptosis and cell cycle control genes, while c9,t11 CLA regulates genes involved in metabolism of arachidonic acid with subsequent impairment of eicosanoids synthesis. Other studies have shown that t10,c12 CLA, but not c9,t11 CLA, can induce fat reduction in adipose tissue and apoptosis of adipocytes in mice.

  16. 49 CFR 173.52 - Classification codes and compatibility groups of explosives.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or hypergolic liquid) E 1.1E1.2E 1.4E Article containing a secondary detonating explosive substance...-S 1.1 1.1A 1.1B 1.1C 1.1D 1.1E 1.1F 1.1G 1.1J 1.1L 9 1.2 1.2B 1.2C 1.2D 1.2E 1.2F 1.2G 1.2H 1.2J 1...

  17. First-principle calculations of structural, electronic, optical, elastic and thermal properties of MgXAs2 (X=Si, Ge) compounds

    NASA Astrophysics Data System (ADS)

    Cheddadi, S.; Boubendira, K.; Meradji, H.; Ghemid, S.; Hassan, F. El Haj; Lakel, S.; Khenata, R.

    2017-12-01

    First-principle calculations on the structural, electronic, optical, elastic and thermal properties of the chalcopyrite MgXAs2 (X=Si, Ge) have been performed within the density functional theory (DFT) using the full-potential linearized augmented plane wave (FP-LAPW) method. The obtained equilibrium structural parameters are in good agreement with the available experimental data and theoretical results. The calculated band structures reveal a direct energy band gap for the interested compounds. The predicted band gaps using the modified Becke-Johnson (mBJ) exchange approximation are in fairly good agreement with the experimental data. The optical constants such as the dielectric function, refractive index, and the extinction coefficient are calculated and analysed. The independent elastic parameters namely, C_{11}, C_{12}, C_{13}, C_{33}, C_{44} and C_{66 } are evaluated. The effects of temperature and pressure on some macroscopic properties of MgSiAs2 and MgGeAs2 are predicted using the quasiharmonic Debye model in which the lattice vibrations are taken into account.

  18. Calculation of Half-Metal, Debye and Curie Temperatures of Co2VAl Compound: First Principles Study

    NASA Astrophysics Data System (ADS)

    Arash, Boochani; Heidar, Khosravi; Jabbar, Khodadadi; Shahram, Solaymani; Masoud Majidiyan, Sarmazdeh; Rohollah Taghavi, Mendi; Sayed, Mohammad Elahi

    2015-05-01

    By FP-LAPW calculations, the structural, elastic, Debye and Curie temperatures, electronic and magnetic properties of Co2 VAl are investigated. The results indicate that Ferromagnetic (FM) phase is more stable than Anti-Ferromagnetic (AFM) and Non-magnetic (NM) ones. In addition, C11-C12 > 0, C44 > 0, and B > 0 so Co2VAl is an elastically stable material with high Debye temperature. Also, the B/G ratio exhibits a ductility behavior. The relatively high Curie temperature provides it as a favorable material for spintronic application. It's electronic and magnetic properties are studied by GGA+U approach leading to a 100% spin polarization at Fermi level. Supported by the simulation of Nano Physics Lab center of Kermanshah Branch, Islamic Azad University

  19. Department of the Army Justification of Estimates for Fiscal Year 1987, Submitted to Congress February 1986. Operation and Maintenance, Army. Volume 1.

    DTIC Science & Technology

    1986-02-01

    Izu ac)L 4)V C rio 2C E-4-4 in 0) M) V VOz V C 0 d 0C 0 C)4 0 C 4 tiC r. . a) ". HL 1- o 0) CC -4 A.) w 4 1-4 :5 c) r_ cC c Ř 0 0 w) W4 0 P-4 a) 0 S 0...CL.C 0.491 hi% % A ~ 9.~§~: ~:~-:*~~.*.-~*:*~~; o~-a’~--o~"T q - 0 t- O OC M -Z oo ’- -- iP - LL. 00 -)N - - CYu LLL; 00-0’JUL) . 0 C n% coO 0 TN N: O om...Crzjz 41 - . *1 4-a 4. -4 . A~’i m* * W0 : ) c a): (0 4.. S 4.10t - *1 5.n- *0 M* -4 0 cn 0 12 ’a .3 w8 -4 C14 0 w . 0 4-4 C ~ 0 * *~ 4J CZ4 ~ 5 D IP tv r

  20. 26 CFR 1.412(c)(1)-1 - Determinations to be made under funding method-terms defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-terms defined. 1.412(c)(1)-1 Section 1.412(c)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Plans, Etc. § 1.412(c)(1)-1 Determinations to be made under funding method—terms defined. (a) Actuarial... bargained plans, see § 1.412(c)(1)-2; for principles applicable to funding methods in general, see...

  1. 26 CFR 1.412(c)(1)-1 - Determinations to be made under funding method-terms defined.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-terms defined. 1.412(c)(1)-1 Section 1.412(c)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT..., Stock Bonus Plans, Etc. § 1.412(c)(1)-1 Determinations to be made under funding method—terms defined. (a... collectively bargained plans, see § 1.412(c)(1)-2; for principles applicable to funding methods in general, see...

  2. 26 CFR 1.412(c)(1)-1 - Determinations to be made under funding method-terms defined.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...-terms defined. 1.412(c)(1)-1 Section 1.412(c)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT..., Stock Bonus Plans, Etc. § 1.412(c)(1)-1 Determinations to be made under funding method—terms defined. (a... collectively bargained plans, see § 1.412(c)(1)-2; for principles applicable to funding methods in general, see...

  3. 26 CFR 1.412(c)(1)-1 - Determinations to be made under funding method-terms defined.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...-terms defined. 1.412(c)(1)-1 Section 1.412(c)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT..., Stock Bonus Plans, Etc. § 1.412(c)(1)-1 Determinations to be made under funding method—terms defined. (a... collectively bargained plans, see § 1.412(c)(1)-2; for principles applicable to funding methods in general, see...

  4. 26 CFR 1.412(c)(1)-1 - Determinations to be made under funding method-terms defined.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...-terms defined. 1.412(c)(1)-1 Section 1.412(c)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT..., Stock Bonus Plans, Etc. § 1.412(c)(1)-1 Determinations to be made under funding method—terms defined. (a... collectively bargained plans, see § 1.412(c)(1)-2; for principles applicable to funding methods in general, see...

  5. Postimplementation Evaluation Plan for the Patient Appointment and Scheduling System at USAF Medical Center, Keesler Air Force Base.

    DTIC Science & Technology

    1983-09-26

    Q.. 5401 Westbard Avenue Bethesda, Maryland 20816 Arthur D Little, Inc c3 11 07 100 SECURITY CLASS:FICAT;ON Of THIS PAGE 𔄃,n Date Entered) REPORT...OFFICE NAME AND ADDRESS 12. REPORT CATE TRIMIS PROGRAM OFFICE September 26, 1983 5401 Westbard Avenue 13. NUMBER OF PAGES Bethesda, Maryland 20816 44

  6. A Bis(pyrazolyl) (bipyridyl) Platinum Complex

    DTIC Science & Technology

    1991-12-01

    Johnson, C. K. (1976) ORTEP-II, A FORTRAN Thermal Ellipsoid Plot Program for Crystal Structure Illustrations. Report ORNL -3794, Third Revision, Oak Ridge...489 5 10 609 578 1411 83 44 2 2 308 296 5 5 245 260 -5 11 -146 85 -1812 -41 14 0 3 764 810 -30 6 1241 1286 -25 12 575 542 1313 584 627 -16 4 160 165

  7. Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice.

    PubMed

    Shaul, Merav E; Bennett, Grace; Strissel, Katherine J; Greenberg, Andrew S; Obin, Martin S

    2010-05-01

    To identify, localize, and determine M1/M2 polarization of epidydimal adipose tissue (eAT) macrophages (Phis) during high-fat diet (HFD)-induced obesity. Male C57BL/6 mice were fed an HFD (60% fat kcal) or low-fat diet (LFD) (10% fat kcal) for 8 or 12 weeks. eATMPhis (F4/80(+) cells) were characterized by in vivo fluorescent labeling, immunohistochemistry, fluorescence-activated cell sorting, and quantitative PCR. Recruited interstitial macrophage galactose-type C-type lectin (MGL)1(+)/CD11c(-) and crown-like structure-associated MGL1(-)/CD11c(+) and MGL1(med)/CD11c(+) eATMPhis were identified after 8 weeks of HFD. MGL1(med)/CD11c(+) cells comprised approximately 65% of CD11c(+) eATMPhis. CD11c(+) eATMPhis expressed a mixed M1/M2 profile, with some M1 transcripts upregulated (IL-12p40 and IL-1beta), others downregulated (iNOS, caspase-1, MCP-1, and CD86), and multiple M2 and matrix remodeling transcripts upregulated (arginase-1, IL-1Ra, MMP-12, ADAM8, VEGF, and Clec-7a). At HFD week 12, each eATMPhi subtype displayed an enhanced M2 phenotype as compared with HFD week 8. CD11c(+) subtypes downregulated IL-1beta and genes mediating antigen presentation (I-a, CD80) and upregulated the M2 hallmark Ym-1 and genes promoting oxidative metabolism (PGC-1alpha) and adipogenesis (MMP-2). MGL1(med)/CD11c(+) eATMPhis upregulated additional M2 genes (IL-13, SPHK1, CD163, LYVE-1, and PPAR-alpha). MGL1(med)/CD11c(+) ATMPhis expressing elevated PGC-1alpha, PPAR-alpha, and Ym-1 transcripts were selectively enriched in eAT of obese mice fed pioglitazone for 6 days, confirming the M2 features of the MGL1(med)/CD11c(+) eATMPhi transcriptional profile and implicating PPAR activation in its elicitation. These results 1) redefine the phenotypic potential of CD11c(+) eATMPhis and 2) suggest previously unappreciated phenotypic and functional commonality between murine and human ATMPhis in the development of obesity and its complications.

  8. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 10. (Hitachi Instruments, Inc.-International Cordage, Inc.)

    DTIC Science & Technology

    1988-01-01

    4 4 4- . 44" loo 1 n 1NN Nl Nl " 4 0 r- r- r-r- r 1% - r.r- lr-..-r Pr l ’)0014 I 0 󈧄V 1 0 󈧄V 100 (10 I " jci "ci C,1 l 1 1 74cI 0 N NNN N 0 N 0e...0N N* 4C N SN C4 C1 SN 1000 1I-C4N N N NNNN C4c jci ,qr N NN ON 0.N(4N U) N UCN ZN I-4N C ZN 1’o00000𔃾) 000000000-)00000000 0 030 0 Q 0 0 0 100 ...1n0.4 - l00om 4 4- 44 4- 4- -4 4 -4 - -4 -4 .- 4-4-1 .-- 4 4 -4 ) -4 lOONi nI I nI I nI i nI I f u,v)lUI u 11) -4 100 -4 m (1 c’) mm ) mMIM ) mM) M c

  9. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 8 (Electronic Design Inc-Florida North Shipyards)

    DTIC Science & Technology

    1990-01-01

    8217- " -" 0 Li A- (:4 Li DC 0 2- 0 U Lic U) D I-- I: Ia 10N II U) Fd - > 2 .~ H C4 " 0)4 -4 < 1 1 <- w 0 Z II - CON 11 W LiJ w Lij 2 Li z44 0 0 < <. 4CC) < Li...04 0C(1 L a 0-4 40> 0 a0c0𔃺a4(N(N(1(’ -CN n -4 " C -00CI -1 (0 M a - 00 M 1.0 C 0 it cd I CON it .LJO C>O ct)00( ~ CaO (D 0 <!> cc.Cc 0)00 a~ O)CO...11 I 4 C )( DC 4- - CON -1 -1N --010001-N-4 4 n-1- 4 1--- 4 -0-4- 400 1 1- - D( ,Z 11 I CN (I "N )CC 0 (D DC000,0(0C 00 0 0 00 0 0 0 000C.a0D<DD I C000

  10. 30 CFR 943.15 - Approval of Texas regulatory program amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...), (f), .195(a); 785.200(a), (b), (c), (f) through (i); 786.216(p); 788.230(a)(4), (5), (6); 788.232(c...), (4), (b); .129, (a), (b), (1), (3); 780.141(g), (h); .142(b)(11), (c), (d), .146 (a) through (e...; 12.77; 12.111(1)(H); 12.112(b)(4); 12.113(a); 12.118(a) and (c); 12.151(a)(2); 12.158(a) and (c); 12...

  11. 77 FR 35617 - Amendment of Class C Airspace; Colorado Springs, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... 44 U.S.C. 1510. #0; #0;The Code of Federal Regulations is sold by the Superintendent of Documents. #0...; Airspace Docket No. 12-AWA-4] Amendment of Class C Airspace; Colorado Springs, CO AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies the Colorado Springs, CO, Class C...

  12. Duration of exposure to multiple antibiotics is associated with increased risk of VRE bacteraemia: a nested case-control study.

    PubMed

    Gouliouris, Theodore; Warne, Ben; Cartwright, Edward J P; Bedford, Luke; Weerasuriya, Chathika K; Raven, Kathy E; Brown, Nick M; Török, M Estée; Limmathurotsakul, Direk; Peacock, Sharon J

    2018-03-13

    VRE bacteraemia has a high mortality and continues to defy control. Antibiotic risk factors for VRE bacteraemia have not been adequately defined. We aimed to determine the risk factors for VRE bacteraemia focusing on duration of antibiotic exposure. A retrospective matched nested case-control study was conducted amongst hospitalized patients at Cambridge University Hospitals NHS Foundation Trust (CUH) from 1 January 2006 to 31 December 2012. Cases who developed a first episode of VRE bacteraemia were matched 1:1 to controls by length of stay, year, specialty and ward type. Independent risk factors for VRE bacteraemia were evaluated using conditional logistic regression. Two hundred and thirty-five cases were compared with 220 controls. Duration of exposure to parenteral vancomycin, fluoroquinolones and meropenem was independently associated with VRE bacteraemia. Compared with patients with no exposure to vancomycin, those who received courses of 1-3 days, 4-7 days or >7 days had a stepwise increase in risk of VRE bacteraemia [conditional OR (cOR) 1.2 (95% CI 0.4-3.8), 3.8 (95% CI 1.2-11.7) and 6.6 (95% CI 1.9-22.8), respectively]. Other risk factors were: presence of a central venous catheter (CVC) [cOR 8.7 (95% CI 2.6-29.5)]; neutropenia [cOR 15.5 (95% CI 4.2-57.0)]; hypoalbuminaemia [cOR 8.5 (95% CI 2.4-29.5)]; malignancy [cOR 4.4 (95% CI 1.6-12.0)]; gastrointestinal disease [cOR 12.4 (95% CI 4.2-36.8)]; and hepatobiliary disease [cOR 7.9 (95% CI 2.1-29.9)]. Longer exposure to vancomycin, fluoroquinolones or meropenem was associated with VRE bacteraemia. Antimicrobial stewardship interventions targeting high-risk antibiotics are required to complement infection control procedures against VRE bacteraemia.

  13. A Coal-Use Economics Methodology for Navy Bases. Phase I of Engineering Services for Coal Conversion Guidance.

    DTIC Science & Technology

    1984-02-01

    ull 4 4: PI) IL .0, so 11 of It it 11 it La W) wl) OQ:222, r,104:01ir Zlow vrp-r- gel Q. I z I ;e z " 0 1.- SIC 44U 14 . I W I C L. Gh vi OZ. I to...0i-a m g U~Nl9a4 q 0 a 2 Cof- aSO JaS4W 4S %I P-2 4S. MS S. I-.U 497 2 a-CS asee v .~A4- N 4 ~ O d C Amea 4-4 2 A =5 .4 -6 .4 C* .Ae-8 - 4 .0 d bAI Iw

  14. Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis

    DTIC Science & Technology

    1986-11-01

    for a diphenyl ether analog ((2) p. 44). 16 - -r , ü$$m&±ysc$c .<v£*^Ä VV’-Orfs aB9*>ratfe>^v CHART NO. 1 8-[(6-AMIDOXIMINOHEXYL)AMINO]-6-METHOXY...MALEATE (SNL-130) cico—(f)V-ci A1C1 CS 1 (58%) • Brü 1) »3PCH2CH2NMe2/n-BuLi 2) H30* 3) Oxalic Acid 4) OH 0 «CHCH,NMe 2ŕ,c2 2 (79%), Free base... diphenyl ether analog ((2) p. 44). A mixture of sodium amide (11.6 g, O.J mol), acetonitrile (15 mL, 11.8 g> 0.29 mol) and dry benzene (1 L) was heated

  15. 49 CFR Appendix A to Part 210 - Summary of Noise Standards, 40 CFR Part 201

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 96 Lmax (fast) Do. All Locomotives Manufactured After 31 December 1979 201.11(b) Stationary, Idle....12(b) Moving 90 Lmax (fast) Do. 201.11(c) and 201.12(c) Additional Requirement for Switcher... Locomotive Noise Exceeds the Receiving Property Limit of 65 L90 (fast) 2 Receiving property 201.11(c...

  16. 49 CFR Appendix A to Part 210 - Summary of Noise Standards, 40 CFR Part 201

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 96 Lmax (fast) Do. All Locomotives Manufactured After 31 December 1979 201.11(b) Stationary, Idle....12(b) Moving 90 Lmax (fast) Do. 201.11(c) and 201.12(c) Additional Requirement for Switcher... Locomotive Noise Exceeds the Receiving Property Limit of 65 L90 (fast) 2 Receiving property 201.11(c...

  17. 49 CFR Appendix A to Part 210 - Summary of Noise Standards, 40 CFR Part 201

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 96 Lmax (fast) Do. All Locomotives Manufactured After 31 December 1979 201.11(b) Stationary, Idle....12(b) Moving 90 Lmax (fast) Do. 201.11(c) and 201.12(c) Additional Requirement for Switcher... Locomotive Noise Exceeds the Receiving Property Limit of 65 L90 (fast) 2 Receiving property 201.11(c...

  18. 49 CFR Appendix A to Part 210 - Summary of Noise Standards, 40 CFR Part 201

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 96 Lmax (fast) Do. All Locomotives Manufactured After 31 December 1979 201.11(b) Stationary, Idle....12(b) Moving 90 Lmax (fast) Do. 201.11(c) and 201.12(c) Additional Requirement for Switcher... Locomotive Noise Exceeds the Receiving Property Limit of 65 L90 (fast) 2 Receiving property 201.11(c...

  19. 49 CFR Appendix A to Part 210 - Summary of Noise Standards, 40 CFR Part 201

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 96 Lmax (fast) Do. All Locomotives Manufactured After 31 December 1979 201.11(b) Stationary, Idle....12(b) Moving 90 Lmax (fast) Do. 201.11(c) and 201.12(c) Additional Requirement for Switcher... Locomotive Noise Exceeds the Receiving Property Limit of 65 L90 (fast) 2 Receiving property 201.11(c...

  20. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 11. Kodet Architectural Group-Mantech Field Engineering.

    DTIC Science & Technology

    1987-01-01

    8217’ C4J C >)> Cm (0 C’) C- ir40 0 -4-4N (4 0 0 .- .>’ .- . ~ - - C 4NL.4- N04.. (0 M’) C -00)0 N U C -(D tD C ,’ m0 0- r, O N N 0 V I- CNFL O4 .0 U 0...10 0646I 0- -I WN 0 Z-D0 I-C’ C-C’) 01 O 6-0 C’)’ C’) 0 ’-40 0l11 0 0 CD C’)U CC C ) TD N0l 06 N- 0.60 00 00000 on 00 0, C. C 000 00 00 000) _𔃺 -’l) U...W LJ "- C C :34 N m4 1 0 w 4 n-it un w N nN r, v 3- 4bD )n0wt400 040 cCO 0n 00 V cl 00a) C)O0LA m-4 I4 N 0413 4 VMPP,?-0V VN 4 (D W 04 4O(D0) 00 cc -4

  1. 25-Hydroxy vitamin D suppresses hepatitis C virus replication and contributes to rapid virological response of treatment efficacy.

    PubMed

    Huang, Jee-Fu; Ko, Yu-Min; Huang, Chung-Feng; Yeh, Ming-Lun; Dai, Chia-Yen; Hsieh, Meng-Hsuan; Huang, Ching-I; Yang, Hua-Ling; Wang, Shu-Chi; Lin, Zu-Yau; Chen, Shinn-Chern; Yu, Ming-Lung; Chuang, Wan-Long

    2017-12-01

    25-Hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection. We aimed to clarify whether HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving antiviral therapy. Cell survival and viral loads were observed in Con1 (genotype 1b) and J6/JFH (genotype 2a) cells treated with different doses of Vit D. Three groups of patients with different treatment responses were recruited to assess their Vit D levels: group A, RVR-/SVR-; group B, RVR+/SVR-; and group C, RVR+/SVR+. The viral load of Con1 cells decreased by 69%, 80%, and 86% following treatment with 1 μM, 5 μM, and 10 μM Vit D, respectively (P < 0.0001). In J6/JFH cells, it decreased by 12%, 55%, and 80.5% following treatment with 1 μM, 5 μM, and 10 μM Vit D, respectively (P < 0.0001). There was a significant increase of Vit D between chronic hepatitis C groups, ranging from 4.4 ± 5.6 ng/mL in group A (n = 44), to 17.2 ± 11.6 ng/mL in group B (n = 44), and 32.5 ± 37.5 ng/mL of group C (n = 44) (P < 0.001). Advanced fibrosis (odds ratio = 0.13, 95% confidence interval = 0.04-0.41, P < 0.001) and Vit D deficiency (<10 ng/mL) (odds ratio = 0.11, 95% confidence interval = 0.03-0.43, P = 0.001) were predictive of SVR in the multivariate regression analysis. Vitamin D decreases HCV replication and also contributes to early treatment viral kinetics. © 2017 The Japan Society of Hepatology.

  2. Supercritical SC-CO(2) and Soxhlet n-Hexane Extract of Tunisian Opuntia ficus indica Seeds and Fatty Acids Analysis.

    PubMed

    Yeddes, Nizar; Chérif, Jamila Kalthoum; Jrad, Amel; Barth, Danielle; Trabelsi-Ayadi, Malika

    2012-01-01

    The fatty acids profiles of Tunisian Opuntia ficus indica seeds (spiny and thornless form) were investigated. Results of supercritical carbon dioxide (SC-CO(2)) and soxhlet n-hexane extract were compared. Quantitatively, the better yield was obtained through soxhlet n-hexane: 10.32% (spiny) and 8.91% (thornless) against 3.4% (spiny) and 1.94% (thornless) by SC-CO(2) extract (T = 40°C, P = 180 bar, time = 135 mn, CO(2) flow rate = 15 mL·s(-1)). Qualitatively, the main fatty acids components were the same for the two types of extraction. Linoleic acid was the major compound, SC-CO(2): 57.60% (spiny), 59.98% (thornless), soxhlet n-hexane: 57.54% (spiny), 60.66% (thornless), followed by oleic acid, SC-CO(2): 22.31% (spiny), 22.40% (thornless), soxhlet n-hexane: 25.28% (spiny), 20.58% (thornless) and palmitic acid, SC-CO(2): 14.3% (spiny), 12.92% (thornless), soxhlet n-hexane: 11.33% (spiny), 13.08% (thornless). The SC-CO(2) profiles fatty acids showed a richness with other minority compounds such as C(20:1), C(20:2), and C(22).The seeds oil was highly unsaturated (US = 4.44-5.25), and the rising temperatures donot affect the selectivity of fatty acids extract by SC-CO2: US = 4.44 (T = 40°C) and 4.13 (T = 70°C).

  3. Supercritical SC-CO2 and Soxhlet n-Hexane Extract of Tunisian Opuntia ficus indica Seeds and Fatty Acids Analysis

    PubMed Central

    Yeddes, Nizar; Chérif, Jamila Kalthoum; Jrad, Amel; Barth, Danielle; Trabelsi-Ayadi, Malika

    2012-01-01

    The fatty acids profiles of Tunisian Opuntia ficus indica seeds (spiny and thornless form) were investigated. Results of supercritical carbon dioxide (SC-CO2) and soxhlet n-hexane extract were compared. Quantitatively, the better yield was obtained through soxhlet n-hexane: 10.32% (spiny) and 8.91% (thornless) against 3.4% (spiny) and 1.94% (thornless) by SC-CO2 extract (T = 40°C, P = 180 bar, time = 135 mn, CO2 flow rate = 15 mL·s−1). Qualitatively, the main fatty acids components were the same for the two types of extraction. Linoleic acid was the major compound, SC-CO2: 57.60% (spiny), 59.98% (thornless), soxhlet n-hexane: 57.54% (spiny), 60.66% (thornless), followed by oleic acid, SC-CO2: 22.31% (spiny), 22.40% (thornless), soxhlet n-hexane: 25.28% (spiny), 20.58% (thornless) and palmitic acid, SC-CO2: 14.3% (spiny), 12.92% (thornless), soxhlet n-hexane: 11.33% (spiny), 13.08% (thornless). The SC-CO2 profiles fatty acids showed a richness with other minority compounds such as C20:1, C20:2, and C22.The seeds oil was highly unsaturated (US = 4.44–5.25), and the rising temperatures donot affect the selectivity of fatty acids extract by SC-CO2: US = 4.44 (T = 40°C) and 4.13 (T = 70°C). PMID:22754699

  4. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Leventhal Bros & Co. Inc. - Martinez A M Construction)

    DTIC Science & Technology

    1994-03-01

    cacau u uIn t c o 3I ac a uu ~In uuuu t aac nu nuCLn wmu u nu wu uu u mm wu II I CO -4eNI 01 - -4---4 -- 4-4-4 4-4 - 4 44------4-4 w4-4-4-4----q-4 ý...4NOH 00 0 0 0 0 0 00 0 0 000 0 If Cg) -4NmlI aWit 11 C -04N( goH .-4-4 ON 01 a) a) a) 010 07111 cc -4 N a H (n1 n U 4 u cc Go :1 (A CACAU (11 (0.- CiN 41

  5. Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11C]Methylation with [11C]CH3I: Rapid Synthesis of [11C]Raclopride.

    PubMed

    Kawashima, Hidekazu; Kimura, Hiroyuki; Nakaya, Yuta; Tomatsu, Kenji; Arimitsu, Kenji; Nakanishi, Hiroaki; Ozeki, Eiichi; Kuge, Yuji; Saji, Hideo

    2015-01-01

    A new radiolabeling method using a microreactor was developed for the rapid synthesis of [(11)C]raclopride. A chip bearing a Y-shaped mixing junction with a 200 µm (width)×20 µm (depth)×250 mm (length) flow channel was designed, and the efficiency of O-[11C]methylation was evaluated. Dimethyl sulfoxide solutions containing the O-desmethyl precursor or [11C]CH3I were introduced into separate injection ports by infusion syringes, and the radiochemical yields were measured under various conditions. The decay-corrected radiochemical yield of microreactor-derived [11C]raclopride reached 12% in 20 s at 25 °C, which was observed to increase with increasing temperature. In contrast, batch synthesis at 25 °C produced a yield of 5%: this indicates that this device could effectively achieve O-[11C]methylation in a shorter period of time. The microreactor technique may facilitate simple and efficient routine production of 11C-labeled compounds via O-[11C]methylation with [11C]CH3I.

  6. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  7. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  8. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  9. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  10. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  11. Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide.

    PubMed

    Shea, Colleen; Alexoff, David L; Kim, Dohyun; Hoque, Ruma; Schueller, Michael J; Fowler, Joanna S; Qu, Wenchao

    2015-08-01

    In this research, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([(11)C]CN¯) produced by our in-house built automated [(11)C]HCN production system and to identify the major sources of (12)C-cyanide ((12)CN¯). The [(11)C]CN¯ is produced from [(11)C]CO2, which is generated by the (14)N(p,α)(11)C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [(11)C]HCN production system were isolated in order to determine their relative contributions to (12)CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33µA for 1 and 10min) did not contribute significantly to the mass. Additionally, we compared the SA of our [(11)C]HCN precursor determined using the ISE to the SA of our current [(11)C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of an ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

    DOE PAGES

    Shea, Colleen; Alexoff, David L.; Kim, Dohyun; ...

    2015-04-25

    In this study, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([ 11C]CN¯) produced by our in-house built automated [ 11C]HCN production system and to identify the major sources of 12C-cyanide ( 12CN¯). The [ 11C]CN¯ is produced from [ 11C]CO 2, which is generated by the 14N(p,α) 11C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [ 11C]HCN production system were isolated in ordermore » to determine their relative contributions to 12CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33 µA for 1 and 10 min) did not contribute significantly to the mass. Additionally, we compared the SA of our [ 11C]HCN precursor determined using the ISE to the SA of our current [ 11C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of an ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose.« less

  13. Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shea, Colleen; Alexoff, David L.; Kim, Dohyun

    In this study, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([ 11C]CN¯) produced by our in-house built automated [ 11C]HCN production system and to identify the major sources of 12C-cyanide ( 12CN¯). The [ 11C]CN¯ is produced from [ 11C]CO 2, which is generated by the 14N(p,α) 11C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [ 11C]HCN production system were isolated in ordermore » to determine their relative contributions to 12CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33 µA for 1 and 10 min) did not contribute significantly to the mass. Additionally, we compared the SA of our [ 11C]HCN precursor determined using the ISE to the SA of our current [ 11C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of an ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose.« less

  14. Tunable polymeric sorbent materials for fractionation of model naphthenates.

    PubMed

    Mohamed, Mohamed H; Wilson, Lee D; Headley, John V

    2013-04-04

    The sorption properties are reported for several examples of single-component carboxylic acids representing naphthenic acids (NAs) with β-cyclodextrin (β-CD) based polyurethane sorbents. Seven single-component examples of NAs were chosen with variable z values, carbon number, and chemical structure as follows: 2-hexyldecanoic acid (z = 0 and C = 16; S1), n-caprylic acid (z = 0 and C = 8; S2), trans-4-pentylcyclohexanecarboxylic acid (z = -2 and C = 12; S3), 4-methylcyclohexanecarboxylic acid (z = -2 and C = 8; S4), dicyclohexylacetic acid (z = -4; C = 14; S5), 4-pentylbicyclo[2.2.2]octane-1-carboxylic acid (z = -4; C = 14; S6), and lithocholic acid (z = -6; C = 24; S7). The copolymer sorbents were synthesized at three relative β-CD:diisocyanate mole ratios (i.e., 1:1, 1:2, and 1:3) using 4,4'-dicyclohexylmethane diisocyanate (CDI) and 4,4'-diphenylmethane diisocyanate (MDI). The sorption properties of the copolymer sorbents were characterized using equilibrium sorption isotherms in aqueous solution at pH 9.00 with electrospray ionization mass spectrometry. The equilibrium fraction of the unbound carboxylate anions was monitored in the aqueous phase. The sorption properties of the copolymer sorbents (i.e., Qm) were obtained from the Sips isotherm model. The Qm values generally decrease as the number of accessible β-CD inclusion sites in the copolymer framework decreases. The chemical structure of the adsorbates played an important role in their relative uptake, as evidenced by the adsorbate lipophilic surface area (LSA) and the involvement of hydrophobic effects. The copolymers exhibit molecular selective sorption of the single-component carboxylates in mixtures which suggests their application as sorbents for fractionation of mixtures of NAs. By comparison, granular activated carbon (GAC) and chitosan sorbents did not exhibit any significant molecular selective sorption relative to the copolymer materials; however, evidence of variable sorption capacity was observed among the sorbents investigated.

  15. Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Barrington, Isld-Williamson, Texas). Part 11

    DTIC Science & Technology

    1994-03-01

    CyC)444 11_ n (0m m m ~ V c0 ( 40 00-4.- 4 -0 -4 -42 z O CAO1000Z de ON I~si CON1 02 0000000000 00 >-0000000000000 Cl!0 X0000 C toON Iiz Cci OOOOOOO 0...C0OV N 4 v de . d 00-49I 0~Ia I r*U- 4 4444 4 4 00ON 0 0 cThII1 600000 N 0004 ULg4 4(< . Co :: en UU4 4 P44 4r,0CUU0 0 0 0 If 1 U 4cqu 0 NIUJ-MG00 0 0 0...m CO) 0 Cq ’D rý 100111OLn mo If I Ca 0 Go 11 om 000 00 . 0 V 0-4 0Ln(DN - 0 M 0040 - 0 m 0OV(D - 0 (D if I cacao 11 z It Z Ln Z Ln-i C r4% z to

  16. 40 CFR 721.10007 - Alcohols, C12-14-secondary, ethoxylated propoxylated.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alcohols, C12-14-secondary... New Uses for Specific Chemical Substances § 721.10007 Alcohols, C12-14-secondary, ethoxylated... identified as alcohols, C12-14- secondary, ethoxylated propoxylated (PMN P-00-11; CAS No. 103331-86-8) is...

  17. 12 CFR 228.11 - Authority, purposes, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Reserve System (12 U.S.C. 325); (2) To conduct examinations of bank holding companies and their.... 1828(c)); (iii) Formations of, acquisitions of banks by, and mergers of, bank holding companies (12 U.S.C. 1842); and (iv) The acquisition of savings associations by bank holding companies (12 U.S.C. 1843...

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwaiger, M.; Hutchins, G.D.; Kalff, V.

    Positron emission tomography in combination with the newly introduced catecholamine analogue ({sup 11}C)hydroxyephedrine (({sup 11}C)HED) enables the noninvasive delineation of sympathetic nerve terminals of the heart. To address the ongoing controversy over possible reinnervation of the human transplant, 5 healthy control subjects and 11 patients were studied after cardiac transplant by this imaging approach. Regional ({sup 11}C)HED retention was compared to regional blood flow as assessed by rubidium-82. Transplant patients were divided into two groups. Group I had recent (less than 1 yr, 4.4 +/- 2.3 mo) surgery, while group II patients underwent cardiac transplantation more than 2 yr beforemore » imaging (3.5 +/- 1.3 yr). ({sup 11}C)HED retention paralleled blood flow in normals, but was homogeneously reduced in group I. In contrast, group II patients revealed heterogeneous ({sup 11}C)HED retention, with increased uptake in the proximal anterior and septal wall. Quantitative evaluation of ({sup 11}C)HED retention revealed a 70% reduction in group I and 59% reduction in group II patients (P less than 0.001). In group II patients, ({sup 11}C)HED retention reached 60% of normal in the proximal anterior wall. These data suggest the presence of neuronal tissue in the transplanted human heart, which may reflect regional sympathetic reinnervation.« less

  19. Outcomes following attempted en bloc resection of cervical chordomas in the C-1 and C-2 region versus the subaxial region: a multiinstitutional experience.

    PubMed

    Molina, Camilo A; Ames, Christopher P; Chou, Dean; Rhines, Laurence D; Hsieh, Patrick C; Zadnik, Patricia L; Wolinsky, Jean-Paul; Gokaslan, Ziya L; Sciubba, Daniel M

    2014-09-01

    Chordomas involving the mobile spine are ideally managed via en bloc resection with reconstruction to optimize local control and possibly offer cure. In the cervical spine, local anatomy poses unique challenges, limiting the feasibility of aggressive resection. The authors present a multi-institutional series of 16 cases of cervical chordomas removed en bloc. Particular attention was paid to clinical outcome, complications, and recurrence. In addition, outcomes were assessed according to position of tumor at the C1-2 level versus the subaxial (SA) spine (C3-7). The authors reviewed cases involving patients who underwent en bloc resection of cervical chordoma at 4 large spine centers. Patients were included if the lesion epicenter involved the C-1 to C-7 vertebral bodies. Demographic data and details of surgery, follow-up course, exposure to adjuvant therapy, and complications were obtained. Outcome was correlated with presence of tumor in C1-2 versus subaxial spine via a Student t-test. Sixteen patients were identified (mean age at presentation 55 ± 14 years). Seven cases (44%) cases involved C1-2, and 16 involved the subaxial spine. Median survival did not differ significantly different between the C1-2 (72 months) and SA (60 months) groups (p = 0.65). A combined (staged anteroposterior) approach was used in 81% of the cases. Use of the combined approach was significantly more common in treatment of subaxial than C1-2 tumors (100% vs 57%, p = 0.04). En bloc resection was attempted via an anterior approach in 6% of cases (C1-2: 14.3%; SA: 0%; p = 0.17) and a posterior approach in 13% of cases (C1-2: 29%; SA: 0%; p = 0.09). The most commonly reported margin classification was marginal (56% of cases), followed by violated (25%) and wide (19%). En bloc excision of subaxial tumors was significantly more likely to result in marginal margins than excision of C1-2 tumors (C1-2: 29%; SA: 78%; p = 0.03). C1-2 tumors were associated with significantly higher rates of postoperative complications (C1-2: 71%; SA: 22%; p = 0.03). Both local and distant tumor recurrence was greatest for C1-2 tumors (local C1-2: 29%; local SA: 11%; distant C1-2: 14%; distant SA: 0%). Statistical analysis of tumor recurrence based on tumor location was not possible due to the small number of cases. There was no between-groups difference in exposure to postoperative adjuvant radiotherapy. There was no difference in median survival between groups receiving proton beam radiotherapy or intensity-modulated radiotherapy versus no radiation therapy (p = 0.8). Compared with en bloc resection of chordomas involving the subaxial cervical spine, en bloc resection of chordomas involving the upper cervical spine (C1-2) is associated with poorer outcomes, such as less favorable margins, higher rates of complications, and increased tumor recurrence. Data from this cohort do not support a statistically significant difference in survival for patients with C1-2 versus subaxial disease, but larger studies are needed to further study survival differences.

  20. Word Frequency Analysis. MOS: 62J. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    WCRDI COUNT2 W OR u, CO UIT 3 WORD 3 COUNT’. kCRD4 I CELL 9 CLNTER I CERERLINE t CENTRALLY 2 C [JTP I FGAL 2 CZRT..IN I CESSIVE 46 LFI’ 14 C H%1% ~ 4...4 .4* 4 AD ,G4 ANGLI 4 fC S 0A 4 r. 5 54b d204 4 BE- J 4OCK4 ECAGNE 4 TTA .(.KFTS 4 B𔃻E.KER 4 44 CC!’PPCT 4 13FL*.~If 4 CCLC CTwV7CCC~L< EL4 CO 4 CE...t CI RE I CARTcUL I CAR7~ I 3 CARRY I CAL 7I C!! 11 E t C., TFPS I CA~TCH I C4TEO I co usIN Kr I CL TC1 I CELL 1CTNlERL!NEz I ’ENI P.LIY Ic3VEI

  1. Military Hydrology. Report 14. Breach Erosion of Earth-Fill Dams and Flood Routing (BEED) Model

    DTIC Science & Technology

    1989-08-01

    1 + 1 )-VC L(I *( HSV -V U/WIVL f 1 ) ISN 11 EN~iF ISN 12 PETURN ISN 13 END B12 I SN I SUBROUTINE COQSOI(H2,QSPL,pSD,,Sp...E71’ TI - 1 , F8F " L -,- ’-. F--- f 4-l- TH8-I., H f { ’ F- . T ’ Ii’< -4- I8- F b’ In - - 184’ a4-, ’’C->’ *A 8 r’lM LAT I V -’ 1 4~ ’ D FFT ’’ P87A...01) THEN HSY=H1-21 ELSE HSV =H2 20,90) GOSUE 44(.0,: VOL2=VL -2(9C) 1 210 COMPUTE SPILLWAYOUTLET &INFLOW DISCHARGES

  2. Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats

    PubMed Central

    Pontes, Henrique Budib Dorsa; Pontes, José Carlos Dorsa Vieira; de Azevedo Neto, Euler; Vendas, Giovanna Serra da Cruz; Miranda, João Victor Cunha; Dias, Letícia do Espírito Santos; Oliva, João Victor Durães Gomes; de Almeida, Murilo Henrique Martins; Chaves, Ian de Oliveira; Sampaio, Tricia Luna; dos Santos, Carlos Henrique Marques; Dourado, Doroty Mesquita

    2018-01-01

    Introduction Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning. Methods 41 Wistar rats (Rattus norvegicus albinus) were distributed in 5 groups: Ischemia and Reperfusion (A), Ischemic Postconditioning (B), Statin (C), Ischemic Postconditioning + Statins (D) and SHAM (E). After euthanasia, lungs, liver, kidneys and ileum were resected and submitted to histopathological analysis. Results The average of lung parenchymal injury was A=3.6, B=1.6, C=1.2, D=1.2, E=1 (P=0.0029). The average of liver parenchymal injury was A=3, B=1.5, C=1.2, D=1.2, E = 0 (P<0.0001). The average of renal parenchymal injury was A=4, B=2.44, C=1.22, D=1.11, E=1 (P<0.0001). The average of intestinal parenchymal injury was A=2, B=0.66, C=0, D=0, E=0 (P=0.0006). The results were submitted to statistics applying Kruskal-Wallis test, estabilishing level of significance P<0.05. Conclusion Groups submitted to ischemic postconditioning, to pre-treatment with statins and both methods associated demonstrated less remote reperfusion injuries, compared to the group submitted to ischemia and reperfusion without protection. PMID:29617505

  3. 49 CFR 173.52 - Classification codes and compatibility groups of explosives.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or hypergolic liquid) E 1.1E1.2E 1.4E Article containing a secondary detonating explosive substance....1E 1.1F 1.1G 1.1J 1.1L 9 1.2 1.2B 1.2C 1.2D 1.2E 1.2F 1.2G 1.2H 1.2J 1.2K 1.2L 10 1.3 1.3C 1.3F 1.3G...

  4. Synthesis of carbon-11-labeled bivalent β-carbolines as new PET agents for imaging of cholinesterase in Alzheimer's disease.

    PubMed

    Wang, Min; Zheng, David X; Gao, Mingzhang; Hutchins, Gary D; Zheng, Qi-Huang

    2011-04-01

    Carbon-11-labeled bivalent β-carbolines, 9,9'-(pentane-1,5-diyl)bis(2-[(11)C]methyl-9H-pyrido[3,4-b]indol-2-ium)iodide ([(11)C]2a), 9,9'-(nonane-1,9-diyl)bis(2-[(11)C]methyl-9H-pyrido[3,4-b]indol-2-ium)iodide ([(11)C]2b), 9,9'-(dodecane-1,12-diyl)bis(2-[(11)C]methyl-9H-pyrido[3,4-b]indol-2-ium)iodide ([(11)C]2c) and 1,9-bis(2-[(11)C]methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)nonane ([(11)C]3), were prepared by N-[(11)C]methylation of their corresponding amine precursors using [(11)C]CH(3)I and isolated by either a simplified solid-phase extraction (SPE) method or HPLC in 40-60% radiochemical yields based on [(11)C]CO(2) and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 20-30min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 185-370 GBq/μmol. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Cultural Resources Literature Search and Records Review - Upper Mississippi River Basin. Volume 7. Pool 6.

    DTIC Science & Technology

    1983-01-01

    H 0- -1 . 0 - d U. 0- 4 X, i * ’w 7 E-4 rj U) r- c0 0 -4 P 4 H4 E-4 E 0- 4%D.10 0 -4 $4 )t% U4 ) H- to) 440 Ur- H- N -4-1 4--)4J 4 4-) U)iU $4 -.4 C...34I W,4. * 4-i W ) U z u L. U U En $-4 $4 -4 X M Z a)~ U4. ) 0 )c~ (a aUD ) La 0 -r - go)> 4l) Cl V U) M l W ’- V U) H-U) -4 35Cl ( P ’.44 0 $- Q ~- -H U...gr I E U C0 0C) t41-H. H- V U) 4.) En 0--4 10uVr LA I H- r- C3 U -4$k V C4J W :: - c Q)~ r. CN C3 r i-, 11 H - N n 04 004 4J E- 4 M 0 04 -4 UU) 94 0 p

  6. Combined Hydrophobic/Oleophobic Membrane Separation and Extraction for Fuel Treatment (Briefing Charts)

    DTIC Science & Technology

    2015-03-24

    Institute, Dayton, OH 45469 4 California State University, Long Beach, CA 90840 5 University of Michigan, Ann Arbor, MI 48109 2 Acknowledgements Ms. Yvonne...ppm) C2 Thiophenes 0.3 C3-C4 Thiophenes 1.4 C5 Thiophenes 3.7 C6 Thiophenes 3.5 C7 Thiophenes 4.1 C8 -C9 Thiophenes 2.9 C10 Thiophenes 0.6 C11...Thiophenes 6.3 C6 Thiophenes 6.1 C7 Thiophenes 5.8 C8 -C9 Thiophenes 4.9 C10 Thiophenes 1.3 C11 Thiophenes 0.9 C12+ Thiophenes 2.0 Standard Grade RP-1 (Errors

  7. Genetic Polymorphisms of Hemostatic Factors and Thrombotic Risk in Non BCR-ABL Myeloproliferative Neoplasms: A Pilot Study

    PubMed Central

    Dambrauskienė, R; Gerbutavičius, R; Ugenskienė, R; Jankauskaitė, R; Savukaitytė, A; Šimoliūnienė, R; Rudžianskienė, M; Gerbutavičienė, R; Juozaitytė, E

    2017-01-01

    Abstract The most important complications of Philadelphianegagive (non BCR-ABL) myeloproliferative neoplasms (MPNs) are vascular events. Our aim was to evaluate the effects of single nucleotide polymorphisms (SNPs), platelet glycoproteins (GPs) (Ia/IIa, Ibα, IIb/IIIa and VI), von Willebrand factor (vWF), coagulation factor VII (FVII), β-fibrinogen, and the risk of thrombosis in patients with non BCR-ABL MPNs at the Lithuanian University of Health Sciences. Kaunas, Lithuania. Genotyping was done for 108 patients. The TT genotype of the GP Ia/IIa c.807C>T polymorphism was more frequently found in the group of MPN patients with arterial thrombosis compared to MPN patients who were thrombosis-free [26.5 vs. 11.5%, p = 0.049; odds ratio (OR) 2.68; 95% confidence interval (95% CI) 1.01-7.38]. The CT genotype of the β-fibrinogen c.-148C>T polymorphism occurred more frequently in MPN patients with arterial, and total thrombosis compared to the wild or homozygous genotype (57.7 vs. 40.0 vs. 12.5%; p = 0.027), (64.7 vs. 44.4 vs. 25%; p = 0.032), respectively. The carrier state for the c.-323P10 variant of FVII SNP (summation of P10/10 and P0/10) was more frequent in MPN patients with thrombosis compared to the wild-type genotype carriers (71.4 vs. 43.4%; p = 0.049; OR 3.26; 95% CI 1.01-11.31). The coexistence of heterozygous β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP, increased the risk of arterial thrombosis (21.1 vs. 3.7%, p = 0.008; OR 6.93; 95% CI 1.38-34.80). The TT genotype of GP Ia/IIa c.807C>T, the CT genotype of β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP could be associated with risk of thrombosis in MPN patients. PMID:28924539

  8. DoD Manual for Standard Data Elements

    DTIC Science & Technology

    1989-07-01

    U4W333Iininin0.0. -)-6-6)---6- Z.............Law0C 44-Lawu Inn44....Jým --- ...- ..... -LaWzaýa ZaW aW>u 0 wwJ 22-. - Lawammi nmm4mm m mm awmwwww w2Z...a a 0 ON wzwzn i 0... ta L--za tun w awawww 4 0 UL OOOOO&WO ~ a. 0- C9 w~a 44U - . = X Z~(n~nZZ4 4 0 44 uJ0 - 0.4- 4-4 &. L 0 Z0000U W b, ta atS w xu...Z -a CW 1 04 Il-w lWa-I- - * U.zU 4 000 2 4N00 ZaW --0-aU.Ji.0 4c 0 W W M- o-t M ma- 0a-s--~0U- ZIW 2 j P- 0W I-a >1(AO i 4 U00.4K 11a-I--I-- j~ at

  9. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 19 (Swanda Brothers Incorporated-TRT Telecommunications Corp)

    DTIC Science & Technology

    1990-01-01

    0000000000 400c 00) -4000C20 (400000 N44V 010 "- K W Io0-4 Kfc oc a c In00000 i4 00 oo %nw 00 000000 0000 (30 Ji K a 1 0-4 KH00000000000 -W4C4- CD0 anw000...44440444444UUU44444 Kf I W-ONO KIf KfC t -4 -4N K. N K I M-40410 K11 K I 00-4iri4I &, mO &n o In in in in 0 In o inY) )ofIn in in o In In 0 DIn 0oIn In...44444444444444 N44 4 *ON co a 4 .- c) in di n I n t t i i An in t mnam bfIn wi wi wmi wa w) wI In in Infin in in In0 S doaN w4 4’m 113(’ a C) VMmmMV MI

  10. Department of the Army Justification of Estimates for FY 1991 Submitted to Congress January 1990. Operation and Maintenance, Army Justification Book. Volume 1

    DTIC Science & Technology

    1990-01-01

    8217 - ’"I Si _ Cr ~J-1 IL tJ -4; 4* V -) a- Nii :1-1 N - *~- ~ - - Flh 31 - ’,- I - , - 241 m -18 ’TNJN V _, ZA- E -t 4 3R 2 u : aF - - *>- -- Lj 0 00...0J~ . -4 4. C C rn~ 00. m * a ) ca Z4 :) af -4 4j Z. Ci o a) rn C.) to ~L C"W.o ) ) u) /3 0 MJ 0 r_4-4- 4-j go u 0 a0 W >to-44L-Ui 4-CJ J4 4J u) u~ E...t J m w-0~ w ~ 0 Z z~ 0 to u wm D m. -X 00’> Q) -~ U cn .- 1~. - 0 Uf.- 0> u0 -j t >C - cn uu 4z vC*-4J mu4- w v Ř-J W~c w w w wCCu ’ Af ~-a ju 0 0 z

  11. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 6. (Dobbins Lou, Inc.-Fahey Machinery Co., Inc.)

    DTIC Science & Technology

    1989-01-01

    0 (-4N4- H0 -.4C.) -. 4 a) () -40) -4 0 ) w 0N %- M C(00) z to IG0 -Iff1 ._40 N I 0 -4 4 5 0 ) L0)) 0 .-. 01-4~ . 0 .4NCJ0) 1-1-4 -4-4 0 )’ ao I -4N... 0 -4 00 0 -n O Olo(c x( c -d0 41r- -C4 N00 to II0 0 - I N N C1,1 0 r -4 -4 r-U 1 0 ... .J0)00N MLI-I0-41 1 00 o0 30- 30 30)mv0v-, 0 a o 5 Qo oN 0114/81 M...100000000000 4I <_1B4.4 110 0D 0n 0n 0 0 00 ofl W I Owl>u if ON 0C Or0N ON" 0 -I

  12. Halocarbons in the stratosphere

    NASA Astrophysics Data System (ADS)

    Fabian, P.; Borchers, R.

    1981-12-01

    The possible impact of chlorine compounds on the Earth's ozone layer has caused concern. Profiles of the anthropogenic halocarbons F-11 (CFC13) and F-12 (CF2Cl2) have already been measured in the stratosphere1-4. Measurements of the vertical distribution of methyl chloride (CH3Cl), the most important natural chlorine-bearing species confirm that chlorine of anthropogenic origin now predominates the stratosphere5,6. More halogen radicals are added through decomposition of various other halocarbons, most of them released by man. We report here the first measurements of vertical profiles of F-13 (CF3Cl), F-14 (CF4), F-113 (C2F3Cl3), F-114 (C2F4Cl2), F-115 (C2F5Cl), F-116 (C2F6), and F-13 B(CF3Br) resulting from gas chromatography-mass spectrometer (GC-MS) analysis of air samples collected cryogenically between 10 and 33 km, at 44° N. Some data for F-22 (CHF2C1), methyl bromide (CH3Br) and methyl chloroform (CH3CC13) also presented are subject to confirmation.

  13. All Prime Contract Awards by State or Country, Place, and Contractor. Part 8 (La Grange Illinois-Wichita, Kansas)

    DTIC Science & Technology

    1990-01-01

    Pr-r-r-rr- P- r-- P-1- vrp-r -- U) 11 CL I 0O 0 CC I - 4 -. 4- 4-. 4- 4 -4 -4 -4-4-4 -4 -4-4 -4 -4 0-4.4 C-4.4-14 Of I W el4 I, 0>00 0 0 00 0 0 0 0 ~N...k 1 -,040 04 )00I(0 I 0 CDa - t 0 w * o- r4 i co - -q00)r- 4o n 0 f- c- -4 el4 to o co 4n ti I a l. I I MC-) 11- 1W it I MC-4 11U U 1 I- IfI M 4 - 0 0...I 90-C40 0 NNNN 00 C4 NI CSI4" wfP 0)l w P-Pt- -4 - * in 0-IN on P-P- P r- G ( Go 00 00 PP 1.- c’ r- ’ Cell T) In 3 II 04NO m (’CIO ’C1C (’I (1 T) C cr

  14. Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa

    DOE PAGES

    Whitney, John C.; Robinson, Howard; Whitfield, Gregory B.; ...

    2015-05-15

    Pseudomonas aeruginosa is an opportunistic human pathogen that secretes the exopolysaccharide alginate during infection of the respiratory tract of individuals afflicted with cystic fibrosis and chronic obstructive pulmonary disease. Among the proteins required for alginate production, Alg44 has been identified as an inner membrane protein whose bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) binding activity post-translationally regulates alginate secretion. In this study, we report the 1.8 Å crystal structure of the cytoplasmic region of Alg44 in complex with dimeric self-intercalated c-di-GMP and characterize its dinucleotide-binding site using mutational analysis. The structure shows that the c-di-GMP binding region of Alg44 adopts a PilZmore » domain fold with a dimerization mode not previously observed for this family of proteins. Moreover, calorimetric binding analysis of residues in the c-di-GMP binding site demonstrate that mutation of Arg-17 and Arg-95 alters the binding stoichiometry between c-di-GMP and Alg44 from 2:1 to 1:1. Introduction of these mutant alleles on the P. aeruginosa chromosome show that the residues required for binding of dimeric c-di-GMP in vitro are also required for efficient alginate production in vivo. Our results suggest that the dimeric form of c-di-GMP represents the biologically active signaling molecule needed for the secretion of an important virulence factor produced by P. aeruginosa.« less

  15. Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whitney, John C.; Robinson, Howard; Whitfield, Gregory B.

    Pseudomonas aeruginosa is an opportunistic human pathogen that secretes the exopolysaccharide alginate during infection of the respiratory tract of individuals afflicted with cystic fibrosis and chronic obstructive pulmonary disease. Among the proteins required for alginate production, Alg44 has been identified as an inner membrane protein whose bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) binding activity post-translationally regulates alginate secretion. In this study, we report the 1.8 Å crystal structure of the cytoplasmic region of Alg44 in complex with dimeric self-intercalated c-di-GMP and characterize its dinucleotide-binding site using mutational analysis. The structure shows that the c-di-GMP binding region of Alg44 adopts a PilZmore » domain fold with a dimerization mode not previously observed for this family of proteins. Moreover, calorimetric binding analysis of residues in the c-di-GMP binding site demonstrate that mutation of Arg-17 and Arg-95 alters the binding stoichiometry between c-di-GMP and Alg44 from 2:1 to 1:1. Introduction of these mutant alleles on the P. aeruginosa chromosome show that the residues required for binding of dimeric c-di-GMP in vitro are also required for efficient alginate production in vivo. Our results suggest that the dimeric form of c-di-GMP represents the biologically active signaling molecule needed for the secretion of an important virulence factor produced by P. aeruginosa.« less

  16. Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa*

    PubMed Central

    Whitney, John C.; Whitfield, Gregory B.; Marmont, Lindsey S.; Yip, Patrick; Neculai, A. Mirela; Lobsanov, Yuri D.; Robinson, Howard; Ohman, Dennis E.; Howell, P. Lynne

    2015-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that secretes the exopolysaccharide alginate during infection of the respiratory tract of individuals afflicted with cystic fibrosis and chronic obstructive pulmonary disease. Among the proteins required for alginate production, Alg44 has been identified as an inner membrane protein whose bis-(3′,5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) binding activity post-translationally regulates alginate secretion. In this study, we report the 1.8 Å crystal structure of the cytoplasmic region of Alg44 in complex with dimeric self-intercalated c-di-GMP and characterize its dinucleotide-binding site using mutational analysis. The structure shows that the c-di-GMP binding region of Alg44 adopts a PilZ domain fold with a dimerization mode not previously observed for this family of proteins. Calorimetric binding analysis of residues in the c-di-GMP binding site demonstrate that mutation of Arg-17 and Arg-95 alters the binding stoichiometry between c-di-GMP and Alg44 from 2:1 to 1:1. Introduction of these mutant alleles on the P. aeruginosa chromosome show that the residues required for binding of dimeric c-di-GMP in vitro are also required for efficient alginate production in vivo. These results suggest that the dimeric form of c-di-GMP represents the biologically active signaling molecule needed for the secretion of an important virulence factor produced by P. aeruginosa. PMID:25817996

  17. Herontwerp Ballistisch vest voor Vrouwen: Fase 1 (Redesign Ballistic Vest for Women: Phase 1)

    DTIC Science & Technology

    2008-09-01

    Cupmaten van de verschillende respondenten. Proefpersoon Cupmaat 1 85b 2 3 80C 4 85g 5 řb 6 80b 7 75b 8 75c 9 75b 10 75alb 11 75ald 12 85c 13 75C 14 80c...Klantmianagement KPU-bedrijf / Vertegenwoordiger KBG vrouwen S. Eckhardt 9 /10 TNO Defensie en Veiligheid. vestiging Soesterberg, (Archief) 11 /12 TNO Defensie...Kampweg 5 PostbUs 23 3769 ZG Soesterberg TNO-rapport www.tno.ni T1+31 346 3562 11 TNO-DV 2008 A323 F +31 346 35 39 77 Info-DenV@tno. n1 Herontwerp

  18. Simultaneous determination of all-trans and 13-cis retinoic acids and their 4-oxo metabolites by adsorption liquid chromatography after solid-phase extraction.

    PubMed

    Lefebvre, P; Agadir, A; Cornic, M; Gourmel, B; Hue, B; Dreux, C; Degos, L; Chomienne, C

    1995-04-07

    All-trans retinoic acid (all-trans RA), the active metabolite of vitamin A, has been demonstrated to be an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia (APL), the AML3 subtype of the FAB cytological classification. Complete remission is obtained by inducing terminal granulocytic differentiation of the leukemic cells. To study all-trans RA pharmacokinetics in patients with APL, a rapid, precise and selective high-performance liquid chromatographic (HPLC) assay was developed. This method is easy and shows good repeatability (C.V. = 8.41-12.44%), reproducibility (C.V. = 9.19-14.73%), accuracy (C.V. = 3.5-11%) and sensitivity with a detection limit of 5 pmol/ml. The analysis is performed using normal-phase HPLC in an isocratic mode with UV detection after solid-phase extraction on octadecyl (C18) columns. The mobile phase is hexane-dichloromethane-dioxane (78:18:4, v/v) containing 1% acetic acid.

  19. Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy

    PubMed Central

    Boulouis, Gregoire; Xiong, Li; Jessel, Michel J.; Roongpiboonsopit, Duangnapa; Ayres, Alison; Schwab, Kristin M.; Rosand, Jonathan; Gurol, M. Edip; Greenberg, Steven M.; Viswanathan, Anand

    2017-01-01

    Objective: To investigate whether cortical superficial siderosis (cSS) is associated with increased risk of future first-ever symptomatic lobar intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA) presenting with neurologic symptoms and without ICH. Methods: Consecutive patients meeting modified Boston criteria for probable CAA in the absence of ICH from a single-center cohort were analyzed. cSS and other small vessel disease MRI markers were assessed according to recent consensus recommendations. Patients were followed prospectively for future incident symptomatic lobar ICH. Prespecified Cox proportional hazard models were used to investigate cSS and first-ever lobar ICH risk adjusting for potential confounders. Results: The cohort included 236 patients with probable CAA without lobar ICH at baseline. cSS prevalence was 34%. During a median follow-up of 3.26 years (interquartile range 1.42–5.50 years), 27 of 236 patients (11.4%) experienced a first-ever symptomatic lobar ICH. cSS was a predictor of time until first ICH (p = 0.0007, log-rank test). The risk of symptomatic ICH at 5 years of follow-up was 19% (95% confidence interval [CI] 11%–32%) for patients with cSS at baseline vs 6% (95% CI 3%–12%) for patients without cSS. In multivariable Cox regression models, cSS presence was the only independent predictor of increased symptomatic ICH risk during follow-up (HR 4.04; 95% CI 1.73–9.44, p = 0.001), after adjusting for age, lobar cerebral microbleeds burden, and white matter hyperintensities. Conclusions: cSS is consistently associated with an increased risk of future lobar ICH in CAA with potentially important clinical implications for patient care decisions such as antithrombotic use. PMID:28356458

  20. 12 CFR 563.41 - Transactions with affiliates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... “OTS,” except for references at 12 CFR 223.2(a)(9)(iv), 223.3(h), 223.3(z), 223.14(c)(4), 223.43, and... identify the circumstance listed in paragraph (c)(4)(i) of this section that supports the imposition of the... implements section 11(a) of the Home Owners' Loan Act (12 U.S.C. 1468(a)). Section 11(a) applies sections 23A...

  1. 12 CFR 563.41 - Transactions with affiliates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... “OTS,” except for references at 12 CFR 223.2(a)(9)(iv), 223.3(h), 223.3(z), 223.14(c)(4), 223.43, and... identify the circumstance listed in paragraph (c)(4)(i) of this section that supports the imposition of the... implements section 11(a) of the Home Owners' Loan Act (12 U.S.C. 1468(a)). Section 11(a) applies sections 23A...

  2. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 3. (Lomita, California-San Bernardino, California).

    DTIC Science & Technology

    1988-01-01

    J000000000000000000000000000000O00000000 -JO .JOO) ICoOL(14 00000000000000000000000000000000000000 0 00C 0 1 MOLA < t- 4- t *I t-*- * -44 -4 4444-t4v4-T-t44 -4...4 -4 I (or- 1𔃾) 471 al 4) 1-- I (0 - I c0 c0 c0 00 I M W0I0 -4 , 4- - - 4--- 4 - 4- 4, -4 -4-4-- -4 4.-4.-4 <-4 4-4-4 <-4 I- I MoLA (0 I (D...34 (0 M0 In (0 (0 I0 (0ON- IC c C c c c c 1(C030(0 14<-4 -4 -4-4 4 -4 4-4 -4-4-4-4-4 -4-4 -4 -4-4 -4-4 -4-4 -4-4 <-4 <-1-4 <-"-4  <. -I MOLA (0I

  3. Crystal structure of 1-ferrocenyl-2-(4-methyl-benzo-yl)spiro-[11H-pyrrolidizine-3,11'-indeno[1,2-b]quinoxaline].

    PubMed

    Chandralekha, Kuppan; Gavaskar, Deivasigamani; Sureshbabu, Adukamparai Rajukrishnan; Lakshmi, Srinivasakannan

    2014-09-01

    In the title compound, [Fe(C5H5)(C34H28N3O)], the four-fused-rings system of the 11H-indeno-[1,2-b]quinoxaline unit is approximately planar [maximum deviation = 0.167 (4) Å] and forms a dihedral angle of 37.25 (6)° with the plane of the benzene ring of the methyl-benzoyl group. Both pyrrolidine rings adopt a twist conformation. An intra-molecular C-H⋯O hydrogen bond is observed. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds and weak C-H⋯π inter-actions, forming double chains extending parallel to the c axis.

  4. 5 CFR 2610.201 - Contents of application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... purpose of its organization or business. The application shall also: (1) Show that the applicant has... Agricultural Marketing Act (12 U.S.C. 1141j(a)). (c) The application shall state the amount of fees and... Office of Management and Budget review under the Paperwork Reduction Act (44 U.S.C. chapter 35) because...

  5. A comparison of complexation of Li+ ion with macrocyclic ligands 15-crown-5 and 12-crown-4 in binary nitromethane-acetonitrile mixtures by using lithium-7 NMR technique and ab initio calculation.

    PubMed

    Alizadeh, Nina

    2011-01-01

    Lithium-7 NMR measurements were used to investigate the stoichiometry and stability of Li+ complexes with 15-crown-5 (15C5), benzo-15-crown-5 (B15C5), dibenzo-15-crown-5 (DB15C5) and 12-crown-4 (12C4) in a number of nitromethane (NM)-acetonitrile (AN) binary mixtures. In all cases, the exchange between the free and complexed lithium ion was fast on the NMR time scale and a single population average resonance was observed. While all crown ethers form 1:1 complexes with Li+ ion in the binary mixtures used, both 1:1 and 2:1 (sandwich) complexes were observed between lithium ion and 12C4 in pure nitromethane solution. Stepwise formation constants of the 1:1 and 2:1 (ligand/metal) complexes were evaluated from computer fitting of the NMR-mole ratio data to equations which relate the observed metal ion chemical shifts to formation constants. There is an inverse linear relationship between the logarithms of the stability constants and the mole fraction of acetonitrile in the solvent mixtures. The stability order of the 1:1 complexes was found to be 15C5·Li+>B15C5·Li+>DB15C5·Li+>12C4·Li+. The optimized structures of the free ligands and their 1:1 and 2:1 complexes with Li+ ion were predicted by ab initio theoretical calculations using the Gaussian 98 software, and the results are discussed. Copyright © 2010 Elsevier B.V. All rights reserved.

  6. Regional brain [(11)C]carfentanil binding following tobacco smoking.

    PubMed

    Domino, Edward F; Hirasawa-Fujita, Mika; Ni, Lisong; Guthrie, Sally K; Zubieta, Jon Kar

    2015-06-03

    To determine if overnight tobacco abstinent carriers of the AG or GG (*G) vs. the AA variant of the human mu opioid receptor (OPRM1) A118G polymorphism (rs1799971) differ in [(11)C]carfentanil binding after tobacco smoking. Twenty healthy American male smokers who abstained from tobacco overnight were genotyped and completed positron emission tomography (PET) scans with the mu opioid receptor agonist, [(11)C]carfentanil. They smoked deniconized (denic) and average nicotine (avnic) cigarettes during the PET scans. Smoking avnic cigarette decreased the binding potential (BPND) of [(11)C]carfentanil in the right medial prefrontal cortex (mPfc; 6, 56, 18), left anterior medial prefrontal cortex (amPfc; -2, 46, 44), right ventral striatum (vStr; 16, 3, -10), left insula (Ins; -42, 10, -12), right hippocampus (Hippo; 18, -6, -14) and left cerebellum (Cbl; -10, -88, -34), and increased the BPND in left amygdala (Amy; -20, 0, -22), left putamen (Put; -22, 10, -6) and left nucleus accumbens (NAcc; -10, 12, -8). In the AA allele carriers, avnic cigarette smoking significantly changed the BPND compared to after denic smoking in most brain areas listed above. However in the *G carriers the significant BPND changes were confirmed in only amPfc and vStr. Free mu opioid receptor availability was significantly less in the *G than the AA carriers in the Amy and NAcc. The present study demonstrates that BPND changes induced by avnic smoking in OPRM1 *G carriers were blunted compared to the AA carriers. Also *G smokers had less free mu opioid receptor availability in Amy and NAcc. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.

    PubMed

    Innocenti, Federico; Kroetz, Deanna L; Schuetz, Erin; Dolan, M Eileen; Ramírez, Jacqueline; Relling, Mary; Chen, Peixian; Das, Soma; Rosner, Gary L; Ratain, Mark J

    2009-06-01

    We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients. Pharmacokinetic, genetic, and clinical data were obtained from 85 advanced cancer patients treated with single-agent CPT-11 every 3 weeks at doses of 300 mg/m(2) (n = 20) and 350 mg/m(2) (n = 65). Forty-two common variants were genotyped in 12 candidate genes of the CPT-11 pathway using several methodologies. Univariate and multivariate models of absolute neutrophil count (ANC) nadir and pharmacokinetic parameters were evaluated. Almost 50% of the variation in ANC nadir is explained by UGT1A1*93, ABCC1 IVS11 -48C>T, SLCO1B1*1b, ANC baseline levels, sex, and race (P < .0001). More than 40% of the variation in CPT-11 area under the curve (AUC) is explained by ABCC2 -24C>T, SLCO1B1*5, HNF1A 79A>C, age, and CPT-11 dose (P < .0001). Almost 30% of the variability in SN-38 (the active metabolite of CPT-11) AUC is explained by ABCC1 1684T>C, ABCB1 IVS9 -44A>G, and UGT1A1*93 (P = .004). Other models explained 17%, 23%, and 27% of the variation in APC (a metabolite of CPT-11), SN-38 glucuronide (SN-38G), and SN-38G/SN-38 AUCs, respectively. When tested in univariate models, pretreatment total bilirubin was able to modify the existing associations between genotypes and phenotypes. On the basis of this exploratory analysis, common polymorphisms in genes encoding for ABC and SLC transporters may have a significant impact on the pharmacokinetics and pharmacodynamics of CPT-11. Confirmatory studies are required.

  8. 4,4'-Dichlorodiphenyltrichloroethane (DDT) and 4,4'-dichlorodiphenyldichloroethylene (DDE) inhibit myogenesis in C2C12 myoblasts.

    PubMed

    Kim, Jonggun; Park, Min Young; Kim, Yoo; Yoon, Kyong Sup; Clark, John Marshall; Park, Yeonhwa; Whang, Kwang-Youn

    2017-12-01

    Most countries have banned the use of 4,4'-dichlorodiphenyltrichloroethane (DDT). However, owing to its extremely high lipophilic characteristics, DDT and its metabolite 4,4'-dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and in many types of food. The positive correlation between exposure to insecticides, including DDT and DDE, and weight gain, resulting in impaired energy metabolism in offspring following perinatal DDT and DDE exposure, was previously reported. Therefore the influence of DDT and DDE on myogenesis using C2C12 myoblasts was investigated in this study. DDT and DDE decreased myotube formation dose- and time-dependently. Among myogenic regulatory factors, DDT and DDE mainly decreased MyoD1 and Myf5 expression. DDT and DDE treatment also altered Myostatin expression, phosphorylation of protein kinase B, p70 ribosomal protein S6 kinase, forkhead box O protein 3 and mammalian target of rapamycin, resulting in attenuation of myotube formation. These results may have significant implications for understanding the effects of developmental exposure of DDT and DDE on myogenesis and development of obesity and type 2 diabetes later in life. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  9. 78 FR 23565 - Determination of Insufficient Assets To Satisfy Claims Against Financial Institution in Receivership

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... costly to the deposit insurance fund (see 12 U.S.C. 1823(c)(4)), the FDIC facilitated a transaction with... most of the assets of the failed institution. Section 11(d)(11)(A) of the FDI Act, 12 U.S.C. 1821(d)(11... by $1,698,423,504. Accordingly, the FDIC has determined that insufficient assets exist to make any...

  10. Task Force Delay Study. Denver Stapleton International Airport, Volume II.

    DTIC Science & Technology

    1980-03-01

    Stephen L. 11. Hockaday Manager Sl H/j c 2nclosure cc: x. Fred Jaeger bcc: Mr. Herb Hubbard, UAL TFD Correspondence H. Fan 0 JI-. *~ ~ E ~ n ti ~’L1 -J (D...34 Attachment E contains a list of additional delay experiments discussed at the previous Task Force meeting. I I P M. M. &6 Co. Mr. Phillip J. LaRochelle March... E -05B Western. C-01, C7.O3, C-05, CO2 , C-04, C-06, Continental,, C-07, C-09, C-11, C-15, C-10, C-12, C-14, C-16 Trans World,, D-01, D-03, D-05, D-07

  11. 77 FR 37614 - Tariffs (Other Than Tariff Review Plan); Connect America Fund; A National Broadband Plan for Our...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ...-109; GN Docket No. 09-51; CC Docket Nos. 01-92, 96-45; WT Docket No. 10-208; FCC 11-161] Tariffs... required by the Paperwork Reduction Act (PRA) of 1995 (44 U.S.C. 3501-3520), 77 FR 20629, April 5, 2012... Reduction Act of 1995 (44 U.S.C. 3507), the FCC is notifying the public that it received OMB approval on May...

  12. Parámetros sagitales espino-pélvicos en una población asintomática Argentina

    PubMed Central

    Guiroy, Alfredo; Gagliardi, Martín; Sícoli, Alfredo; Masanés, Nicolás Gonzalez; Ciancio, Alejandro Morales; Jalón, Pablo; Mezzadri, Juan José

    2018-01-01

    Resumen Introducción: Analizar y describir los parámetros sagitales espinales y pelvianos de una serie de 100 voluntarios argentinos. Métodos: Se realizaron prospectivamente espinogramas digitalizados de perfil a 100 voluntarios (30 hombres y 70 mujeres), con un promedio de edad 34,14 años. Todos los voluntarios eran asintomáticos al momento de realizarse el estudio. Los espinogramas se hicieron en un equipo Kodak Elite CR. Se realizaron las mediciones usando el software Surgimap®, versión 2.2.9.9.2. Se tomaron los siguientes parámetros: C7 SVA, C2-C7 CL, TK, LL, TPA, T1 tilt, PI, PT, SS, ángulo L4-S1, ángulo L1-L4, PI-LL y CTPA. Los datos fueron analizados empleando el paquete estadístico Medcalc 11.2. Se determinaron las estadísticas descriptivas adecuadas para cada variable según su escala de medición y distribución. Se realizó la estimación de intervalos de referencia del 95% y de intervalos de confianza del 95% para todas las variables. Así, el nivel de significación obtenido fue igual a 0.05. Se dividió a los voluntarios según la clasificación morfométrica de Roussouly en cuatro tipos. Resultados: El promedio para cada variable fue CL −10.04, TK 30.14, T1SPi −6.5, L1-L4 −12.45, L4-S1 −46.16, CTPA 2.5, TPA 4.65, PT 11.22, PI 48.04, LL −59.10, PI-LL −11.11, C7 SVA mm −23.68. Los ±2 desvíos estándar para cada variable fueron: CL (−33.26, 13.12); TK (17.15, 43.30); T1SPi (−11.78, −1.25), L1-L4 (−25.55, 0.25), L4-S1 (−64.44, −27.55), CTPA (0.33, 4.80), TPA (−8.64, 18.22), PT (−1.99, 24.75), PI (25.23, 71.44), LL (−78.74, −39.89), PI-LL (−29.10, 7.04), C7 SVA mm (−79.45, 32.08). Conclusión: En esta serie prospectiva de 100 adultos voluntarios se determinaron los valores de normalidad de los parámetros sagitales espinales y pelvianos en una población de Argentina. PMID:29430329

  13. Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Fiscal Year 1993. (Lytron Incorporated-Quest Integrated). Part 4

    DTIC Science & Technology

    1994-03-01

    I QQ Q 0 0 @ NN N@0 Q 0 Q QO a 0 (n . 4140 m 0 C-2 a %n mN N N ~ N N U 00 I 00 A 43N~ 4,11 VA 4y 0I a, *I a.f~ 0.0 a, a,4 a- 0 % 0N N (IA01.-4 Ca a...qoi ni 4V m I I I -4 .0 m m IN C : 101 C, 00N1 E II 4 A .4 IN U 0I1 0 Q N40 C44 NO .4 00 a0 0 114 Owa 06 0 0 I$ me 10-0 -0 0 001I . 4140 -IS 4 ’t 0601...4 I .4 -4 4 to -i 4 4~ a. .4 6 60 I414 ~ 4 6 64 1. CO 3 I5 I xi 1 1 4E M 4 t)c nA I ~ I 4* 4 .4 .~. I l44 40 44 1 43 1 1.4 44 . 4 46 4 44116 3~ 4140

  14. Further identification of endogenous gibberellins in the shoots of pea, line G2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Halinska, A.; Davies, P.J.; Lee, J.W.

    1989-12-01

    To interpret the metabolism of radiolabeled gibberellins A{sub 12}-aldehyde and A{sub 12} in shoots of pea (Pisum sativum L.), the identity of the radiolabeled peaks has to be determined and the endogenous presence of the gibberellins demonstrated. High specific activity ({sup 14}C)GA{sub 12} and ({sup 14}C)GA{sub 12}-aldehyde were synthesized using a pumpkin endosperm enzyme preparation, and purified by high performance liquid chromatography (HPLC). ({sup 14}C)GA{sub 12} was supplied to upper shoots of pea, line G2, to produce radiolabeled metabolites on the 13-OH pathway. Endogenous compounds copurifying with the ({sup 14}C)GAs on HPLC were analyzed by gas chromatography-mass spectrometry. The endogenousmore » presence of GA{sub 53}, GA{sub 44}, GA{sub 19} and GA{sub 20} was demonstrated and their HPLC peak identity ascertained. The {sup 14}C was progressively diluted in GAs further down the pathway, proportional to the levels found in the tissue and inversely proportional to the speed of metabolism, ranging from 63% in GA{sub 53} to 4% in GA{sub 20}. Calculated levels of GA{sub 20}, GA{sub 19}, GA{sub 44}, and GA{sub 53} were 42, 8, 10, and 0.5 nanograms/gram, respectively.« less

  15. Analysis and theoretical modeling of 18O enriched carbon dioxide spectrum by CRDS near 1.35 μm: (II) 16O13C18O, 16O13C17O, 12C18O2, 17O12C18O, 12C17O2, 13C18O2 and 17O13C18O

    NASA Astrophysics Data System (ADS)

    Karlovets, E. V.; Campargue, A.; Kassi, S.; Tashkun, S. A.; Perevalov, V. I.

    2017-04-01

    This contribution is the second part of the analysis of the room temperature absorption spectrum of 18O enriched carbon dioxide by very high sensitivity Cavity Ring Down spectroscopy between 6977 and 7918 cm-1 (1.43-1.26 μm). Overall, more than 8600 lines belonging to 166 bands of eleven carbon dioxide isotopologues were rovibrationnally assigned. In a first part (Kassi et al. J Quant Spectrosc Radiat Transfer 187 (2017) 414-425, http://dx.doi.org/10.1016/j.jqsrt.2016.09.002), the results relative to mono-substituted isotopologues, 16O12C18O, 16O12C17O, 12C16O2 and 13C16O2, were presented. This second contribution is devoted to the multiply-substituted isotopologues or clumped isotopologues of particular importance in geochemistry: 16O13C18O, 16O13C17O, 12C18O2, 17O12C18O, 12C17O2, 13C18O2 and 17O13C18O. On the basis of the predictions of effective Hamiltonian models, a total of 3195 transitions belonging to 73 bands were rovibrationnally assigned for these seven species. Among the 73 observed bands, 55 are newly reported. All the identified bands correspond to ΔP=10 and 11 series of transitions, where P= 2V1+V2+3V3 is the polyad number (Vi are vibrational quantum numbers). The accurate spectroscopic parameters of 70 bands have been determined from the standard band-by-band analysis. Global fits of the measured line intensities of the ΔP=10 series of transitions of 17O12C18O and 16O13C18O and of the ΔP=11 series of transitions of 12C18O2, 17O12C18O, 16O13C18O and 13C18O2 were performed to determine the corresponding sets of the effective dipole moment parameters.

  16. 76 FR 78126 - Disclosure Requirements for Depository Institutions Lacking Federal Deposit Insurance (Regulation I)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... and Comment The Administrative Procedure Act (APA) \\11\\ generally requires public notice and an opportunity to comment before promulgation of substantive regulations.\\12\\ The APA provides exceptions to... APA's notice-and-comment requirements. \\11\\ 5 U.S.C. 551 et seq. \\12\\ 5 U.S.C. 553(b), (c). \\13\\ 5 U.S...

  17. Bioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells.

    PubMed

    Hu, Suwen; Deng, Lei; Wang, Huamao; Zhuang, Yingping; Chu, Ju; Zhang, Siliang; Li, Zhonghai; Guo, Meijin

    2011-05-01

    The mouse-human chimeric anti-epidermal growth factor receptor vIII (EGFRvIII) antibody C12 is a promising candidate for the diagnosis of hepatocellular carcinoma (HCC). In this study, 3 processes were successfully developed to produce C12 by cultivation of recombinant Chinese hamster ovary (CHO-DG44) cells in serum-free medium. The effect of inoculum density was evaluated in batch cultures of shaker flasks to obtain the optimal inoculum density of 5 × 10(5) cells/mL. Then, the basic metabolic characteristics of CHO-C12 cells were studied in stirred bioreactor batch cultures. The results showed that the limiting concentrations of glucose and glutamine were 6 and 1 mM, respectively. The culture process consumed significant amounts of aspartate, glutamate, asparagine, serine, isoleucine, leucine, and lysine. Aspartate, glutamate, asparagine, and serine were particularly exhausted in the early growth stage, thus limiting cell growth and antibody synthesis. Based on these findings, fed-batch and perfusion processes in the bioreactor were successfully developed with a balanced amino acid feed strategy. Fed-batch and especially perfusion culture effectively maintained high cell viability to prolong the culture process. Furthermore, perfusion cultures maximized the efficiency of nutrient utilization; the mean yield coefficient of antibody to consumed glucose was 44.72 mg/g and the mean yield coefficient of glutamine to antibody was 721.40 mg/g. Finally, in small-scale bioreactor culture, the highest total amount of C12 antibody (1,854 mg) was realized in perfusion cultures. Therefore, perfusion culture appears to be the optimal process for small-scale production of C12 antibody by rCHO-C12 cells.

  18. Novel routes to 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines.

    PubMed

    Katritzky, Alan R; Jain, Ritu; Xu, Yong-Jiang; Steel, Peter J

    2002-11-15

    Condensation reactions of benzotriazole and 2-(pyrrol-1-yl)-1-ethylamine (1) with formaldehyde and glutaric dialdehyde, respectively, afforded intermediates 2 and 6. Subsequent nucleophilic substitutions of the benzotriazole group in 2 and 6 with Grignard reagents, sodium cyanide, and sodium borohydride gave 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines 3a-e, 4, 5 and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines 7a-c, 8, 9, respectively, in good yields.

  19. T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.

    PubMed

    Bou Ghanem, Elsa N; Nelson, Christina C; D'Orazio, Sarah E F

    2011-02-01

    A subset of CD44(hi)CD8(+) T cells isolated from C57BL/6/J (B6) mice, but not BALB/c/By/J (BALB/c) mice, rapidly secrete IFN-γ within 16 h of infection with Listeria monocytogenes. This Ag-independent response requires the presence of both IL-12 and IL-18. Previous studies showed that dendritic cells from B6 mice produced more Th1-type cytokines such as IL-12 than did those from BALB/c mice in response to L. monocytogenes infection. In this report, we demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive B6 CD8(+) T cells to rapidly secrete IFN-γ. Furthermore, BALB/c CD8(+) T cells did not rapidly secrete IFN-γ even when they were exposed to high concentrations of IL-12 plus IL-18 in vitro. In the presence of IL-12 and IL-18, B6 CD44(hi)CD8(+) T cells upregulated expression of the receptor subunits for these cytokines more rapidly than did BALB/c T cells. In comparing particular subsets of memory phenotype CD8(+) T cells, we found that virtual memory cells, rather than true Ag-experienced cells, had the greatest level of impairment in BALB/c mice. These data suggest that the degree of cytokine-driven bystander activation of CD8(+) T cells that occurs during infection depends on both APCs and T cell-intrinsic properties that can vary among mouse strains.

  20. Correlation between caloric and ocular vestibular evoked myogenic potential test results.

    PubMed

    Huang, Chi-Hsuan; Wang, Shou-Jen; Young, Yi-Ho

    2012-02-01

    The ocular vestibular evoked myogenic potential (o-VEMP) test results correlate significantly with caloric test results for patients with acoustic neuroma (AN), but not for patients with Meniere's disease (MD), indicating that the o-VEMP test may replace the caloric test for evaluating the vestibular nerve from which the AN arises. Conversely, the caloric, o-VEMP, and cervical VEMP (c-VEMP) tests should be performed to map lesion sites in the vestibular labyrinth. This study performed caloric, o-VEMP, and c-VEMP tests on patients with central and peripheral vestibular disorders to investigate their relationships. In all, 66 patients comprising 16 with unilateral AN and 50 with unilateral definite MD were enrolled. All patients underwent caloric, o-VEMP, and c-VEMP tests. In the AN group, the caloric test identified canal paresis and caloric areflexia in 10 ears, while the o-VEMP and c-VEMP tests identified abnormal (absent or delayed) responses in 12 and 11 ears, respectively. A significant correlation existed between caloric and o-VEMP test results, but not between caloric and c-VEMP test results, or between o-VEMP and c-VEMP test results. For the MD group, abnormal caloric, o-VEMP, and c-VEMP test results were obtained for 24%, 44%, and 38% of hydropic ears, respectively. No correlation existed between any two test results.

  1. Role of IKK-alpha in EGFR Signaling Regulation

    DTIC Science & Technology

    2013-09-01

    correlated with IKKα expression using CCLE. Nonsupervised hierarchical clustering analysis was performed based on Erbb2, ERα ( ESR1 ), PR (PgR...signature (ERBB2, ESR1 , and PGR) genes. A subset of 4 genes showing distinct expression pattern in TNBC versus non-TNBC cell lines is shown in the...AKT2 AKT3 CDH1 MYB CDH2 VIM ERBB2 ESR1 PGR H C C 11 87 C A L- 85 -1 H C C 11 43 H D Q -P 1 C A L- 51 H C C 38 H C C 21 57 C A L- 12 0 B T- 54 9 H C C

  2. Investigation of Modularly Configured Attached Processors with Intelligent Memories

    DTIC Science & Technology

    1994-09-30

    sequence of computations becomes cl = c11 + C[i, i] := Cli, j] + A[i, k) * Blk, j]; al x bti, c12 - c12 + k X bkX2, C13 = C1 3 + alk X b 3 , ... , c =n...Cin + alk X bkn, C2 1 = Cat + a2k x bkl , The sequence of computations becomes cii = a I x bli, C22 = cU2 + a2k x b2, ... Cj a2 1x bij, ca3j = aa x...1 to 1/2 Least significant 1/2 address bits Fig. 1. Block diagram of a memory module PREGVJKE is v I pis P16 16 ItO16 = 4-81T OECD - = AMKSS A s-Byrf

  3. The conformations of 13-vertex ML2C2B10 metallacarboranes: experimental and computational studies.

    PubMed

    Dalby, Kelly J; Ellis, David; Erhardt, Stefan; McIntosh, Ruaraidh D; Macgregor, Stuart A; Rae, Karen; Rosair, Georgina M; Settels, Volker; Welch, Alan J; Hodson, Bruce E; McGrath, Thomas D; Stone, F Gordon A

    2007-03-21

    The docosahedral metallacarboranes 4,4-(PMe(2)Ph)2-4,1,6-closo-PtC(2)B(10)H(12), 4,4-(PMe(2)Ph)2-4,1,10-closo-PtC(2)B(10)H(12), and [N(PPh(3))2][4,4-cod-4,1,10-closo-RhC(2)B(10)H(12)] were prepared by reduction/metalation of either 1,2-closo-C(2)B(10)H(12) or 1,12-closo-C(2)B(10)H(12). All three species were fully characterized, with a particular point of interest of the latter being the conformation of the {ML2} fragment relative to the carborane ligand face. Comparison with conformations previously established for six other ML(2)C(2)B(10) species of varying heteroatom patterns (4,1,2-MC(2)B(10), 4,1,6-MC(2)B(10), 4,1,10-MC(2)B(10), and 4,1,12-MC(2)B(10)) reveals clear preferences. In all cases a qualitative understanding of these was afforded by simple MO arguments applied to the model heteroarene complexes [(PH3)2PtC(2)B(4)H(6)]2- and [(PH3)2PtCB(5)H(6)]3-. Moreover, DFT calculations on [(PH3)2PtC(2)B(4)H(6)]2- in its various isomeric forms approximately reproduced the observed conformations in the 4,1,2-, 4,1,6-, and 4,1,10-MC(2)B(10) species, although analogous calculations on [(PH3)2PtCB(5)H(6)]3- did not reproduce the conformation observed in the 4,1,12-MC(2)B(10) metallacarborane. DFT calculations on (PH3)2PtC(2)B(10)H(12) yielded good agreement with experimental conformations in all four isomeric cases. Apparent discrepancies between observed and computed Pt-C distances were probed by further refinement of the 4,1,2- model to 1,2-(CH2)3-4,4-(PMe3)2-4,1,2-closo-PtC(2)B(10)H(10). This still has a more distorted structure than measured experimentally for 1,2-(CH2)3-4,4-(PMe(2)Ph)2-4,1,2-closo-PtC(2)B(10)H(10), but the structural differences lie on a very shallow potential energy surface. For the model compound a henicosahedral transition state was located 8.3 kcal mol(-1) above the ground-state structure, consistent with the fluxionality of 1,2-(CH2)3-4,4-(PMe(2)Ph)2-4,1,2-closo-PtC(2)B(10)H(10) in solution.

  4. 12 CFR 362.11 - Activities of insured State savings associations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... amount exceeding that described in section 5(c)(2)(B) of HOLA (12 U.S.C. 1464(c)(2)(B)), unless one of... section 5(c)(2)(B) of HOLA, if the savings association files a notice in compliance with § 303.141 of this...

  5. Determination of the δ13C of dissolved inorganic carbon in water; RSIL lab code 1710

    USGS Publications Warehouse

    Singleton, Glenda L.; Revesz, Kinga; Coplen, Tyler B.

    2012-01-01

    The purpose of the Reston Stable Isotope Laboratory (RSIL) lab code 1710 is to present a method to determine the δ13C of dissolved inorganic carbon (DIC) of water. The DIC of water is precipitated using ammoniacal strontium chloride (SrCl2) solution to form strontium carbonate (SrCO3). The δ13C is analyzed by reacting SrCO3 with 100-percent phosphoric acid (H3PO4) to liberate carbon quantitatively as carbon dioxide (CO2), which is collected, purified by vacuum sublimation, and analyzed by dual inlet isotope-ratio mass spectrometry (DI-IRMS). The DI-IRMS is a DuPont double-focusing mass spectrometer. One ion beam passes through a slit in a forward collector and is collected in the rear collector. The other measurable ion beams are collected in the front collector. By changing the ion-accelerating voltage under computer control, the instrument is capable of measuring mass/charge (m/z) 45 or 46 in the rear collector and m/z 44 and 46 or 44 and 45, respectively, in the front collector. The ion beams from these m/z values are as follows: m/z 44 = CO2 = 12C16O16O, m/z 45 = CO2 = 13C16O16O primarily, and m/z 46 = CO2 = 12C16O18O primarily. The data acquisition and control software calculates δ13C values.

  6. Algorithm for Surface of Translation Attached Radiators (A-STAR). Volume III. Computer Codes.

    DTIC Science & Technology

    1982-05-01

    SEGMENT ARRAYS* C2075 CCPMCN /83jTI 44DDFNPTNBAND C2080 COM MCN IBDT21 N’,RL.YR(831, yS(83)eYS1(82).XB1(82) C2085 COMMON /GOT?/ 14(82)PSVt .12).CVt82 C2090...i a.4 ZZaZ lti 12 )-ZCI CI 10 RH020 . XNXX +VV*VV*ZZ*ZZ 2’ REaS REINZ 4 A3mA IUC 49CEXPI-U*SK*ER R14.IP I RR 8 CEDGE(SOT j-E(OOE(CA IMPEOANCE ELEMENTS...FvAv.S~%Lt IAXpSIIs PINER) 57*f ?C ********* ************* i5?C COM ~PLEX SIFIPSON INTEGRATION RflUTINE.j7 i N E.x,!& pSvsIPK Il~~i Agj:;)2c.19v20 5ON

  7. Design and Real-Time Implementation of a Baseband LPC Coder for Speech Transmission over 9600 BPS Noisy Channels. Volume II. Programming Listings.

    DTIC Science & Technology

    1980-02-01

    cwc N (w~ mm. IDmm m w. C. msite &C-ew %a~m MCI I Di . m1a.2 ,% v oa m.1] W.k1i . . 13.M mmm r, q.W.3.44. I&1242 %D2 1.J1 M.1. ItP a b nNM - f .M2 47 4...a a a a a.a a.a0 IBM a aa a11,11 a .0 a1 . U q M4 MS K IaI u C% A4 U u0 1. w4 . N MKV Ia IO1 U a,". 44 4 .4 N m N N N N N6 N N N (M M M M U M M M CD

  8. Hydrothermal synthesis and structural analysis of new mixed oxyanion borates: Ba11B26O44(PO4)2(OH)6, Li9BaB15O27(CO3) and Ba3Si2B6O16

    NASA Astrophysics Data System (ADS)

    Heyward, Carla; McMillen, Colin D.; Kolis, Joseph

    2013-07-01

    Several new borate compounds, Ba11B26O44(PO4)2(OH)6 (1), Li9BaB15O27(CO3) (2), and Ba3Si2B6O16 (3) were synthesized containing other hetero-oxyanion building blocks in addition to the borate frameworks. They were all prepared under hydrothermal conditions and characterized by single crystal and powder X-ray diffraction, and IR spectroscopy. Crystal data: For 1; space group P21/c, a=6.8909 (14) Å, b=13.629 (3) Å, c=25.851 (5) Å, β=90.04 (3)°; For 2; space group P-31c, a=8.8599 (13) Å, c=15.148 (3) Å; For 3; space group P-1, a=5.0414 (10) Å, b=7.5602 (15) Å, c=8.5374 (17) Å, α=77.15 (3)°, β=77.84 (3)°, γ=87.41 (3)° for 3. Compounds 1 and 2 contain isolated oxyanions [PO4]3- and [CO3]2- respectively, sitting in channels created by the borate framework, while structure 3 has the [SiO4]4- groups directly bonded to the borate groups creating a B-O-Si framework.

  9. Synthesis, antifungal activity and docking study of 2-amino-4H-benzochromene-3-carbonitrile derivatives

    NASA Astrophysics Data System (ADS)

    Mirjalili, BiBi Fatemeh; Zamani, Leila; Zomorodian, Kamiar; Khabnadideh, Soghra; Haghighijoo, Zahra; Malakotikhah, Zahra; Ayatollahi Mousavi, Seyyed Amin; Khojasteh, Shaghayegh

    2016-07-01

    Pathogenic fungi are associated with diseases ranging from simple dermatosis to life-threatening infections, particularly in immunocompromised patients. During the past two decades, resistance to established antifungal drugs has increased dramatically and has made it crucial to identify novel antimicrobial compounds. Here, we selected 12 new compounds of 2-amino-4H-benzochromene-3-carbonitrile drivetives (C1-C12) for synthesis by using nano-TiCl4.SiO2 as efficient and green catalyst, then nine of synthetic compounds were evaluated against different species of fungi, positive gram and negative gram of bacteria. Standard and clinical strains of antibiotics sensitive and resistant fungi and bacteria were cultured in appropriate media. Biological activity of the 2-amino-4H-benzochromene-3-carbonitrile derivatives against fungi and bacteries were estimated by the broth micro-dilution method as recommended by clinical and laboratory standard institute (CLSI). In addition minimal fangicidal and bactericial concenteration of the compounds were also determined. Considering our results showed that compound 2-amino-4-(4-methyl benzoate)-4H-benzo[f]chromen-3-carbonitrile (C9) had the most antifungal activity against Aspergillus clavatus, Candida glabarata, Candida dubliniensis, Candida albicans and Candida tropicalis at concentrations ranging from 8 to ≤128 μg/mL. Also compounds 2-amino-4-(3,4-dimethoxyphenyl)-4H-benzo[f]chromen-3-carbonitrile (C4) and 2-amino-4-(4-isopropylphenyl)-4H-benzo[f]chromen-3-carbonitrile (C3) had significant inhibitory activities against Epidermophyton floccosum following 2-amino-4-(4-methylbenzoate)-4H-benzo[f]chromen-3-carbonitrile (C9), respectively. Docking simulation was performed to insert compounds C3, C4 and C9 in to CYP51 active site to determine the probable binding model.

  10. Evaluation of CLSI M44-A2 Disk Diffusion and Associated Breakpoint Testing of Caspofungin and Micafungin Using a Well-Characterized Panel of Wild-Type and fks Hot Spot Mutant Candida Isolates▿

    PubMed Central

    Arendrup, Maiken Cavling; Park, Steven; Brown, Steven; Pfaller, Michael; Perlin, David S.

    2011-01-01

    Disk diffusion testing has recently been standardized by the CLSI, and susceptibility breakpoints have been established for several antifungal compounds. For caspofungin, 5-μg disks are approved, and for micafungin, 10-μg disks are under evaluation. We evaluated the performances of caspofungin and micafungin disk testing using a panel of Candida isolates with and without known FKS echinocandin resistance mechanisms. Disk diffusion and microdilution assays were performed strictly according to CLSI documents M44-A2 and M27-A3. Eighty-nine clinical Candida isolates were included: Candida albicans (20 isolates/10 mutants), C. glabrata (19 isolates/10 mutants), C. dubliniensis (2 isolates/1 mutant), C. krusei (16 isolates/3 mutants), C. parapsilosis (14 isolates/0 mutants), and C. tropicalis (18 isolates/4 mutants). Quality control strains were C. parapsilosis ATCC 22019 and C. krusei ATCC 6258. The correlations between zone diameters and MIC results were good for both compounds, with identical susceptibility classifications for 93.3% of the isolates by applying the current CLSI breakpoints. However, the numbers of fks hot spot mutant isolates misclassified as being susceptible (S) (very major errors [VMEs]) were high (61% for caspofungin [S, ≥11 mm] and 93% for micafungin [S, ≥14 mm]). Changing the disk diffusion breakpoint to S at ≥22 mm significantly improved the discrimination. For caspofungin, 1 VME was detected (a C. tropicalis isolate with an F76S substitution) (3.5%), and for micafungin, 10 VMEs were detected, the majority of which were for C. glabrata (8/10). The broadest separation between zone diameter ranges for wild-type (WT) and mutant isolates was seen for caspofungin (6 to 12 mm versus −4 to 7 mm). In conclusion, caspofungin disk diffusion testing with a modified breakpoint led to excellent separation between WT and mutant isolates for all Candida species. PMID:21357293

  11. Elasticity of superhydrous phase, B, Mg10Si3O14(OH)4

    NASA Astrophysics Data System (ADS)

    Mookherjee, Mainak; Tsuchiya, Jun

    2015-01-01

    We have used first principles simulation based on density functional theory to calculate the equation of state and elasticity of superhydrous phase B, Mg10Si3O14(OH)4. The pressure-volume results for superhydrous phase B is well represented by a third order Birch-Murnaghan formulation, with K0 = 161.8 (±0.2) GPa and K0‧ = 4.4 (±0.01). The calculated full elastic tensor at 0 GPa is in good agreement with Brillouin scattering results, with the compressional elastic constants: c11 = 329.5 GPa, c22 = 294.9 GPa, c33 = 306.8 GPa, the shear elastic constants - c44 = 99.8 GPa, c55 = 98 GPa, and c66 = 99 GPa; the off-diagonal elastic constants c12 = 82.5 GPa, c13 = 84.6 GPa, and c23 = 98.7 GPa. At the depths corresponding to the mantle transition zone, the aggregate sound wave velocities for superhydrous phase B is slower compared to dry ringwoodite which is the dominant mineral phase. However, hydrous ringwoodite bulk sound velocities are comparable to that of superhydrous phase B. Majoritic garnet, the second most abundant mineral in the transition zone, has bulk sound wave velocities slower than superhydrous phase B. An assemblage consisting of hydrous ringwoodite, superhydrous phase B, and majorite garnet could account for the low velocities observed in certain subduction zone settings at depths corresponding to the base of the transition zone and upper mantle. Superhydrous phase B exhibits moderate single-crystal elastic anisotropy with AVP ∼ 3% and AVS ∼ 5% at the base of the transition zone. Single-crystal elastic anisotropy of other dense hydrous magnesium silicate phases phase such as hydrous phase D is significantly larger at these conditions and might play a major role in explaining the observed mid mantle seismic anisotropy.

  12. Total cardiovascular risk profile of Taiwanese vegetarians.

    PubMed

    Chen, C-W; Lin, Y-L; Lin, T-K; Lin, C-T; Chen, B-C; Lin, C-L

    2008-01-01

    Although the health benefits of vegetarian diets have been well documented among Western population, there are geographic differences of vegetarian diets and the health benefits of the Taiwanese vegetarian diet have not been studied extensively. In addition to conventional risk factors, homocysteine and high-sensitivity C-reactive protein (hs-CRP) levels have been found to predict first atherothrombotic events. We undertook this study to examine the total risk profile of Taiwanese vegetarians. A total of 198 healthy subjects (99 vegetarians and 99 omnivores) were recruited. Fasting blood samples were analyzed for glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count, hs-CRP and homocysteine. There was no significant difference in age, body mass index, blood glucose, white blood cell count, triglyceride and HDL-C between the two groups. The vegetarian group had significantly more females (65.7 vs 46.5%); lower body weight (58.66+/-11.13 vs 62.88+/-12.24 kg); shorter height (159.14+/-7.88 vs 162.53 +/-8.14 cm); lower total cholesterol (184.74+/-33.23 vs 202.01+/-41.05 mg/dl); and lower LDL-C (119.63+/-31.59 vs 135.89+/-39.50 mg/dl). Hs-CRP was significantly lower (0.14+/-0.23 vs 0.23+/-0.44 mg/dl, P=0.025), whereas homocysteine was significantly higher (10.97+/-6.69 vs 8.44+/-2.50 micromol/l, P=0.001) in vegetarians than omnivores. Taiwanese vegetarians have lower total cholesterol, LDL-C and hs-CRP levels, and higher homocysteine levels than omnivores. Owing to different predictive value of each risk factor, the Taiwanese vegetarians had a better cardiovascular risk profile than omnivores. Whether the Taiwanese vegetarian diet should be supplemented with vitamin B(12) to lower serum homocysteine level remains to be addressed.

  13. Crystal structure of 4,4′-(disulfanediyl)dibutanoic acid–4,4′-bipyridine (1/1)

    PubMed Central

    Atria, Ana María; Garland, Maria Teresa; Baggio, Ricardo

    2014-01-01

    4,4′-(Disulfanediyl)dibutanoic acid (dtba) and 4,4′-bipyridine (4,4′-bpy) crystallize in an 1:1 ratio, leading to the title co-crystal with composition C8H14O4S2·C10H8N2. A distinctive feature of the crystal structure is the geometry of the dtba moiety, which appears to be stretched [with a 9.98 (1) Å span between outermost carbons] and acts as an hydrogen-bonding connector, forming linear chains along [-211] with the 4,4′-bpy moiety by way of O—H⋯N hydrogen bonds and C—H⋯O interactions. The influence of the mol­ecular shape on the hydrogen-bonding pattern is analysed by comparing the title compound and two other 4,4′-bpy co-crystals with closely related mol­ecules of similar formulation but different geometry, showing the way in which this correlates with the packing arrangement. PMID:25309167

  14. FP-LAPW study of structural, electronic, elastic, mechanical and thermal properties of AlFe intermetallic

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jain, Ekta, E-mail: jainekta05@gmail.com; Pagare, Gitanjali, E-mail: gita-pagare@yahoo.co.in; Sanyal, S. P., E-mail: sps.physicsbu@gmail.com

    2016-05-06

    The structural, electronic, elastic, mechanical and thermal properties of AlFe intermetallic compound in B{sub 2}-type (CsCl) structure have been investigated using first-principles calculations. The exchange-correlation term was treated within generalized gradient approximation. Ground state properties i.e. lattice constants (a{sub 0}), bulk modulus (B) and first-order pressure derivative of bulk modulus (B’) are presented. The density of states are derived which show the metallic character of present compound. Our results for C{sub 11}, C{sub 12} and C{sub 44} agree well with previous theoretical data. Using Pugh’s criteria (B/G{sub H} < 1.75), brittle character of AlFe is satisfied. In addition shear modulusmore » (G{sub H}), Young’s modulus (E), sound wave velocities and Debye temperature (θ{sub D}) have also been estimated.« less

  15. Elastic properties of some transition metal arsenides

    NASA Astrophysics Data System (ADS)

    Nayak, Vikas; Verma, U. P.; Bisht, P. S.

    2018-05-01

    The elastic properties of transition metal arsenides (TMAs) have been studied by employing Wien2K package based on density functional theory in the zinc blende (ZB) and rock salt (RS) phase treating valance electron scalar relativistically. Further, we have also treated them non-relativistically to find out the relativistic effect. We have calculated the elastic properties by computing the volume conservative stress tensor for small strains, using the method developed by Charpin. The obtained results are discussed in paper. From the obtained results, it is clear that the values of C11 > C12 and C44 for all the compounds. The values of shear moduli of these compounds are also calculated. The internal parameter for these compounds shows that ZB structures of these compounds have high resistance against bond order. We find that the estimated elastic constants are in good agreement with the available data.

  16. Prime Contract Awards by State or Country, Place and Contractor. Part 3 (Lodi, California - Saint Helena, California), FY1991

    DTIC Science & Technology

    1991-01-01

    ea0-4 Nm z (022 222(D Z1) ( ULL. .L L. WO LL A-l.. c2Zz U’) >2z ə 0 itUN o l 0) r- 0 0o 0D 00 -4 N" IX of < ) Nf Ijww - -. 1 c") 00 -4-4 -4 -4 11 1...on v ~ (()C) n =C’) 0D K1 = 0(0 xI ZO 00 00 0000 00 0000 0000 X0000 moo Zoo M000000 ZODOOOOOO Zoo 0) K 0 I t 0(D < I to ) in inCI)11UUI) ini SALE )n ni

  17. Work Values of Hispanic and Mainstream Navy Recruits.

    DTIC Science & Technology

    1982-03-01

    E . aniel. C hmnain IL 61820 ..... ._- _ 1CONTROLI ING OPPIC4 NAME AND ADDRESS IL REPOT OATS Organizational Effectiveness Research-Group Office of...to . 4-4*- 0 e 2$ 0 do to o .0 S!* 0o 0:0 0- UlC) 0. 44 . tOt 4f4) V- j t P4 2 03 094 00 0 1 -0 j C X N :1 g.0.0 4𔃾 CD 03 0 0 to 0 00 03 12 vi t0... c r .4~ H . . %% 0 0 r . 4-1 to~ q. 4) t 0O) to to > "A 1 t U) 4~ ’ -% ~ Ze lo ~ A 4J136 0 . 0) 0) . w - 4 0 4J~ to0 4.) 0. 0 z z t4 C .

  18. Effect of the CYP2C19 genotype on the pharmacokinetics of icotinib in healthy male volunteers.

    PubMed

    Ruan, Can-Jun; Liu, Dong-Yang; Jiang, Ji; Hu, Pei

    2012-12-01

    Icotinib hydrochloride {4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline hydrochloride}, a novel epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), was designed for the treatment of non-small cell lung cancer (NSCLC). In the present study, we investigated the influence of the CYP2C19*2 and CYP2C19*3 alleles on the pharmacokinetics of icotinib in healthy Chinese volunteers. In a single-dose pharmacokinetic study, 12 healthy Chinese volunteers received an oral dose of 600 mg of icotinib. Plasma was sampled for up to 72 h post-dose, followed by quantification of icotinib by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS-MS). Five subjects genotyped as homozygous extensive metabolizers (CYP2C19*1/*1), 6 subjects genotyped as heterozygous extensive metabolizers (CYP2C19*1/*2 or CYP2C19*1/*3), and 1 subject genotyped as a poor metabolizer (CYP2C19*2/*3) and was withdrawn from the research because of urticaria. The mean icotinib AUC(0-∞) and C(max) (14.56 ±5.31 h mg/L and 2.32 ± 0.49 μg/mL) in homozygous EMs was 1.56 and 1.41-fold lower than that in heterozygous EMs (22.7 ± 6.11 and 3.28 ± 0.48, P = 0.046 and 0.047). The mean CL/F (44.18 ± 12.17 L/h) in homozygous EMs was 1.55-fold higher than that in heterozygous EMs (28.42 ± 9.23 L/h, P = 0.013). The data showed that the pharmacokinetics of icotinib differ significantly between homozygous EMs and heterozygous EMs in CYP2C19.

  19. Hydroconversion of methyl laurate on bifunctional Ni2P/AlMCM-41 catalyst prepared via in situ phosphorization using triphenylphosphine

    NASA Astrophysics Data System (ADS)

    Zhao, Sha; Zhang, Zhena; Zhu, Kongying; Chen, Jixiang

    2017-05-01

    A series of Ni2P/AlMCM-41-x bifunctional catalysts with different Si/Al ratios (x) were synthesized by in situ phosphorization of Ni/AlMCM-41-x with triphenylphosphine (nominal Ni/P ratio of 0.75) at 300 °C on a fixed-bed reactor. For comparison, NiP/AlMCM-41-5-TPR was also prepared by the TPR method from the supported nickel phosphate with the Ni/P ratio of 1.0, during which metallic Ni rather than Ni2P formed. TEM images show that Ni and Ni2P particles uniformly distributed in Ni2P/AlMCM-41-x and NiP/AlMCM-41-5-TPR. The Ni2P/AlMCM-41-x acidity increased with decreasing the Si/Al ratio. In the hydroconversion of methyl laurate, the conversions were close to 100% on all catalysts at 360 °C, 3.0 MPa, methyl laurate WHSV of 2 h-1 and H2/methyl laurate ratio of 25. As to Ni2P/AlMCM-41-x, with decreasing the Si/Al ratio, the total selectivity to C11 and C12 hydrocarbons decreased, while the total selectivity to isoundecane and isododecane (Si-C11+i-C12) firstly increased and then decreased. Ni2P/AlMCM-41-5 gave the largest Si-C11+i-C12 of 43.2%. While NiP/AlMCM-41-5-TPR gave higher Si-C11+i-C12 than Ni2P/AlMCM-41-5, it was more active for the undesired Csbnd C bond cleavage and methanation. We propose that the in-situ phosphorization adopted here is a promising approach to preparing Ni2P-based bifunctional catalysts.

  20. Laser ablation molecular isotopic spectrometry of carbon isotopes

    NASA Astrophysics Data System (ADS)

    Bol‧shakov, Alexander A.; Mao, Xianglei; Jain, Jinesh; McIntyre, Dustin L.; Russo, Richard E.

    2015-11-01

    Quantitative determination of carbon isotopes using Laser Ablation Molecular Isotopic Spectrometry (LAMIS) is described. Optical emission of diatomic molecules CN and C2 is used in these measurements. Two quantification approaches are presented: empirical calibration of spectra using a set of reference standards and numerical fitting of a simulated spectrum to the experimental one. Formation mechanisms of C2 and CN in laser ablation plasma are briefly reviewed to provide insights for implementation of LAMIS measurements. A simulated spectrum of the 12C2 Swan system was synthesized using four constituents within 473.5-476.5 nm. Simulation included three branches of 12C2 (1-0), branches R(0-0) and R(1-1), and branch P(9-8) of 12C2. Spectral positions of the tail lines in R(0-0) and R(1-1) were experimentally measured, since they were not accurately known before. The Swan band (1-0) of the isotopologue 13C12C was also simulated. Fitting to the experimental spectrum yielded the ratio 13C/12C = 1.08% in a good agreement with measurements by isotope ratio mass spectrometry. LAMIS promises to be useful in coal, oil and shale exploration, carbon sequestration monitoring, and agronomy studies.

  1. Quantitative skeletal evaluation based on cervical vertebral maturation: a longitudinal study of adolescents with normal occlusion.

    PubMed

    Chen, L; Liu, J; Xu, T; Long, X; Lin, J

    2010-07-01

    The study aims were to investigate the correlation between vertebral shape and hand-wrist maturation and to select characteristic parameters of C2-C5 (the second to fifth cervical vertebrae) for cervical vertebral maturation determination by mixed longitudinal data. 87 adolescents (32 males, 55 females) aged 8-18 years with normal occlusion were studied. Sequential lateral cephalograms and hand-wrist radiographs were taken annually for 6 consecutive years. Lateral cephalograms were divided into 11 maturation groups according to Fishman Skeletal Maturity Indicators (SMI). 62 morphological measurements of C2-C5 at 11 different developmental stages (SMI1-11) were measured and analysed. Locally weighted scatterplot smoothing, correlation coefficient analysis and variable cluster analysis were used for statistical analysis. Of the 62 cervical vertebral parameters, 44 were positively correlated with SMI, 6 were negatively correlated and 12 were not correlated. The correlation coefficients between cervical vertebral parameters and SMI were relatively high. Characteristic parameters for quantitative analysis of cervical vertebral maturation were selected. In summary, cervical vertebral maturation could be used reliably to evaluate the skeletal stage instead of the hand-wrist radiographic method. Selected characteristic parameters offered a simple and objective reference for the assessment of skeletal maturity and timing of orthognathic surgery. Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  2. 78 FR 8185 - Endangered and Threatened Wildlife and Plants; Initiation of 5-Year Status Reviews of 44 Species...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ...-FF01E00000] Endangered and Threatened Wildlife and Plants; Initiation of 5- Year Status Reviews of 44 Species....C. 1531 et seq.), we maintain Lists of Endangered and Threatened Wildlife and Plants (which we... 17.12 (for plants). Section 4(c)(2)(A) of the Act requires us to review each listed species' status...

  3. Elastic medium equivalent to Fresnel's double-refraction crystal.

    PubMed

    Carcione, José M; Helbig, Klaus

    2008-10-01

    In 1821, Fresnel obtained the wave surface of an optically biaxial crystal, assuming that light waves are vibrations of the ether in which longitudinal vibrations (P waves) do not propagate. An anisotropic elastic medium mathematically analogous to Fresnel's crystal exists. The medium has four elastic constants: a P-wave modulus, associated with a spherical P wave surface, and three elastic constants, c(44), c(55), and c(66), associated with the shear waves, which are mathematically equivalent to the three dielectric permittivity constants epsilon(11), epsilon(22), and epsilon(33) as follows: mu(0)epsilon(11)<==>rho/c(44), mu(0)epsilon(22)<==>rho/c(55), mu(0)epsilon(33)<==>rho/c(66), where mu(0) is the magnetic permeability of vacuum and rho is the mass density. These relations also represent the equivalence between the elastic and electromagnetic wave velocities along the principal axes of the medium. A complete mathematical equivalence can be obtained by setting the P-wave modulus equal to zero, but this yields an unstable elastic medium (the hypothetical ether). To obtain stability the P-wave velocity has to be assumed infinite (incompressibility). Another equivalent Fresnel's wave surface corresponds to a medium with anomalous polarization. This medium is physically unstable even for a nonzero P-wave modulus.

  4. Tensile properties of V-Cr-Ti alloys after exposure in oxygen-containing environments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Natesan, K.; Soppet, W.K.

    A systematic study was conducted to evaluate the oxidation kinetics of V-4Cr-4Ti (44 alloy) and V-5Cr-5Ti alloys (55 alloy) and to establish the role of oxygen ingress on the tensile behavior of the alloys at room temperature and at 500 C. The oxidation rate of the 44 alloy is slightly higher than that of the 55 alloy. The oxidation process followed parabolic kinetics. Maximum engineering stress for 55 alloy increased with an increase in oxidation time at 500 C. The maximum stress values for 55 alloy were higher at room temperature than ta 500 C for the same oxidation treatment.more » Maximum engineering stresses for 44 alloy were substantially lower than those for 55 alloy in the same oxidation {approx}500 h exposure in air at 500 C; the same values were 4.8 and 6.1%, respectively, at 500 C after {approx}2060 h oxidation in air at 500 C. Maximum engineering stress for 44 alloy at room temperature was 421.6--440.6 MPa after {approx}250 h exposure at 500 C in environments with a pO{sub 2} range of 1 {times} 10{sup {minus}6} to 760 torr. The corresponding uniform and total elongation values were 11--14.4% and 14.5--21.7%, respectively. Measurements of crack depths in various specimens showed that depth is independent of pO{sub 2} in the preexposure environment and was of 70--95 {micro}m after 250--275 h exposure at 500 C.« less

  5. 40 CFR 721.5358 - 2-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen sulfates. 721.5358 Section 721.5358...-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen.... hydrogen sulfates (PMN P-99-928; CAS No. 222975-06-6) is subject to reporting under this section for the...

  6. 40 CFR 721.5358 - 2-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs. hydrogen sulfates. 721.5358 Section 721.5358...-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs. hydrogen.... hydrogen sulfates (PMN P-99-928; CAS No. 222975-06-6) is subject to reporting under this section for the...

  7. 40 CFR 721.5358 - 2-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen sulfates. 721.5358 Section 721.5358...-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen.... hydrogen sulfates (PMN P-99-928; CAS No. 222975-06-6) is subject to reporting under this section for the...

  8. 40 CFR 721.5358 - 2-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen sulfates. 721.5358 Section 721.5358...-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14-alkyloxy) ethoxy] derivs. hydrogen.... hydrogen sulfates (PMN P-99-928; CAS No. 222975-06-6) is subject to reporting under this section for the...

  9. 40 CFR 721.5358 - 2-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs. hydrogen sulfates. 721.5358 Section 721.5358...-propanol, 1,1′,1′-nitrilotris-, compds. with ethanol 2-[2-(C12-14- alkyloxy) ethoxy] derivs. hydrogen.... hydrogen sulfates (PMN P-99-928; CAS No. 222975-06-6) is subject to reporting under this section for the...

  10. 40 CFR 52.2020 - Identification of plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Compliance and test methods 11/1/97 6/8/98, 63 FR 31116 (c)(131). Subchapter D—Motor Vehicle Emissions.../02 12/8/04, 69 FR 70893 (c)(229). Section 130.108 Test procedures 10/5/02 12/8/04, 69 FR 70893 (c....414 Modification of variance 10/11/08 10/18/10, 75 FR 63717. TEST METHODS Section 130.431 Testing for...

  11. Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.

    PubMed

    Wang, Huan; Kwak, Dongmin; Fassett, John; Liu, Xiaohong; Yao, Wu; Weng, Xinyu; Xu, Xin; Xu, Yawei; Bache, Robert J; Mueller, Daniel L; Chen, Yingjie

    2017-05-01

    Inflammatory responses play an important role in the development of left ventricular (LV) hypertrophy and dysfunction. Recent studies demonstrated that increased T-cell infiltration and T-cell activation contribute to LV hypertrophy and dysfunction. Dendritic cells (DCs) are professional antigen-presenting cells that orchestrate immune responses, especially by modulating T-cell function. In this study, we investigated the role of bone marrow-derived CD11c + DCs in transverse aortic constriction (TAC)-induced LV fibrosis and hypertrophy in mice. We observed that TAC increased the number of CD11c + cells and the percentage of CD11c + MHCII + (major histocompatibility complex class II molecule positive) DCs in the LV, spleen and peripheral blood in mice. Using bone marrow chimeras and an inducible CD11c + DC ablation model, we found that depletion of bone marrow-derived CD11c + DCs significantly attenuated LV fibrosis and hypertrophy in mice exposed to 24 weeks of moderate TAC. CD11c + DC ablation significantly reduced TAC-induced myocardial inflammation as indicated by reduced myocardial CD45 + cells, CD11b + cells, CD8 + T cells and activated effector CD8 + CD44 + T cells in LV tissues. Moreover, pulsing of autologous DCs with LV homogenates from TAC mice promoted T-cell proliferation. These data indicate that bone marrow-derived CD11c + DCs play a maladaptive role in hemodynamic overload-induced cardiac inflammation, hypertrophy and fibrosis through the presentation of cardiac self-antigens to T cells.

  12. Multi-Day Air Saturation at 20 and 22 FSW With Direct Ascent: Data Report on Project 92-09

    DTIC Science & Technology

    2002-03-01

    0802 0 air L/S; Divers 7, 8, 9, 10, 11, 12 0803 22 air R/B Feb 09 1919 22 air DMO entry, Diver 12 has scratchy throat and post-nasal drip, given aspirin...10,11, fsw 12 _ Galley is shipshape as is food. 1919 8 OK Robinson 12 describes scratchy throat & post nasal drip with ????? with purulent nasal...Ball 12 scratchy throat , sniffles, ASA 2 PO every 4 hrs 9 no c/o 7 no c/o 10 no c/o 11 mild congestion, Sudafed 60 mg Divers in good spirits 1250 8

  13. 78 FR 50147 - 2012 Liquid Chemical Categorization Updates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ..., Alkenyl(C12+) acid ester mixture... Alkyl acrylate-Vinylpyridine copolymer in toluene *.... Y Alkylbenzene...) phenylamine in aromatic solvents Y Alkyl(C9+) benzenes Y Alkyl(C11-C17) benzene sulfonic acid Y Alkylbenzene sulfonic acid (4% or less) Alkyl dithiocarbamate (C19-C35) Y Alkyl dithiothiadiazole (C6-C24) Y Alkyl ester...

  14. Electrochemical, spectroscopic, and DFT study of C60(CF3)n frontier orbitals (n = 2-18): the link between double bonds in pentagons and reduction potentials.

    PubMed

    Popov, Alexey A; Kareev, Ivan E; Shustova, Natalia B; Stukalin, Evgeny B; Lebedkin, Sergey F; Seppelt, Konrad; Strauss, Steven H; Boltalina, Olga V; Dunsch, Lothar

    2007-09-19

    The frontier orbitals of 22 isolated and characterized C(60)(CF(3))(n) derivatives, including seven reported here for the first time, have been investigated by electronic spectroscopy (n = 2 [1], 4 [1], 6 [2], 8 [5], 10 [6], 12 [3]; the number of isomers for each composition is shown in square brackets) fluorescence spectroscopy (n = 10 [4]), cyclic voltammetry under air-free conditions (all compounds with n

  15. Plasma Hormone Concentrations in Monkeys after Spaceflight

    NASA Technical Reports Server (NTRS)

    Grindeland, Richard E.; Mukku, V. R.; Dotsenko, R.; Gosselink, K. L.; Bigbee, A. J.; Helwig, D.; Hargens, Alan R. (Technical Monitor)

    1997-01-01

    The aim of this study was to determine the effects of a 12.5 day spaceflight on the endocrine status of Rhesus monkeys. Male monkeys (three to four years old; 4 kg) were adapted to chair restraint and trained for 20 months. Blood samples were obtained from four control (C) and two flight (F) monkeys preflight (PF), post-flight (Recovery-R; days 0, 3, 11, and 17), and before and after a mission length simulation (S). Cortisol, T4, T3, testosterone (T), and IGF-1 were measured by RIA (radioimmunassay). Growth hormone (GH) was measured by an in vitro bioassay. Cortisol (16-34 ug/dl), T4 (3.9-7.4 ug/dl), and T (0.2-0.4 mg/ml) did not differ between F and C or between PF, R, and S samples. The low T values reflect the immaturity of the animals. In F, T3 fell from C levels of 208 +/- 4 ng/dl to 44 on R+0 and 150 on R+3, then returned to C. F showed a 55% decrease in GH at R+0 and decreases of 93, 89, and 80%, respectively, at R+3, 11, and 17. IGF-1 decreased from PF levels of 675 ng/ml to 365 (R+0) and 243 (R+3), but returned to C at R+11. GH and IGF-1 levels before and after S did not differ from each other or from C. The cause of the transitory decrease in T3 is unknown. The suppressed GH levels for 17 days after flight may reflect reduced proprioceptive input during flight. The faster recovery of IGF-1 suggests that factors other than reduced GH secretion are involved.

  16. In Vitro Stability of Free and Glucuronidated Cannabinoids in Blood and Plasma Following Controlled Smoked Cannabis

    PubMed Central

    Karschner, Erin L.; Desrosiers, Nathalie A.; Gorelick, David A.; Huestis, Marilyn A.

    2013-01-01

    BACKGROUND Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples. METHODS Low and high blood and plasma pools were created for each of 10 participants after they smoked a cannabis cigarette. The stabilities of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol (CBD), cannabinol (CBN), THC-glucuronide, and THCCOOH-glucuronide were determined after 1 week at room temperature; 1, 2, 4, 12, and 26 (±2) weeks at 4 °C; and 1, 2, 4, 12, 26 (±2), and 52 (±4) weeks at −20 °C. Stability was assessed by Friedman test. RESULTS Numbers of THC-glucuronide and CBD-positive blood samples were insufficient to assess stability. In blood, 11-OH-THC and CBN were stable for 1 week at room temperature, whereas THC and THCCOOH-glucuronide decreased and THCCOOH increased. In blood, THC, THCCOOH-glucuronide, THCCOOH, 11-OH-THC, and CBN were stable for 12, 4, 4, 12, and 26 weeks, respectively, at 4 °C and 12, 12, 26, 26, and 52 weeks at −20 °C. In plasma, THC-glucuronide, THC, CBN, and CBD were stable for 1 week at room temperature, whereas THCCOOH-glucuronide and 11-OH-THC decreased and THCCOOH increased. In plasma, THC-glucuronide, THC, THCCOOH-glucuronide, THCCOOH, 11-OH-THC, CBN, and CBD were stable for 26, 26, 2, 2, 26, 12, and 26 weeks, respectively, at 4 °C and 52, 52, 26, 26, 52, 52, and 52 weeks, respectively, at −20 °C. CONCLUSIONS Blood and plasma samples should be stored at −20 °C for no more than 3 and 6 months, respectively, to assure accurate cannabinoid quantitative results. PMID:23519966

  17. Analysis of Intrinsic Stability Criteria for Isotropic Third-Order Green Elastic and Compressible Neo-Hookean Solids

    DTIC Science & Technology

    2014-03-01

    components with increasing pressure. At high pressures, this tendency may lead to the onset of instability and subsequent amor - phization (Chen et al...C0IJKLMNEIJEKLEMN ¼ 1 2 C0abEaEb þ 1 6 C0abvEaEbEv: ð2:28Þ Stress S and tangent modulus C are Sa ¼ C0abEb þ 1 2 C0abvEbEv; Cab ¼ C 0 ab þ C 0 abvEv: ð2:29Þ Second...123Þ: ð2:33Þ Second-order compliance components M0ab ¼ ½C 0 ab 1 are M011 ¼ C011 þ C 0 12 ðC011 C 0 12ÞðC 0 11 þ 2C 0 12Þ ; M012 ¼ C012 ðC011 C 0

  18. Synthesis and characterization of aluminum- and gallium-bridged [1.1]chromarenophanes and [1.1]molybdarenophanes.

    PubMed

    Lund, Clinton L; Schachner, Jörg A; Burgess, Ian J; Quail, J Wilson; Schatte, Gabriele; Müller, Jens

    2008-07-07

    The synthesis and structural characterization of the first [1.1]chromarenophanes and the first [1.1]molybdarenophanes are described. A salt-metathesis reaction of [2-(Me 2NCH 2)C 6H 4]AlCl 2 with freshly prepared [Cr(LiC 6H 5) 2].TMEDA (TMEDA = N, N, N', N'-tetramethylethylenediamine) resulted in the dialumina[1.1]chromarenophane [{2-(Me 2NCH 2)C 6H 4}Al(eta (6)-C 6H 5) 2Cr] 2 ( 2a). The poor solubility of 2a in organic solvents prompted us to synthesize the new intramolecularly coordinated aluminum- and gallium dichlorides [5- tBu-2-(Me 2NCH 2)C 6H 3]ECl 2 [E = Al ( 3a), Ga ( 3b)] in which the phenyl group was equipped with a tert-butyl group. Salt-metathesis reactions of 3a and 3b, respectively, with freshly prepared [M(LiC 6H 5) 2].TMEDA (M = Cr, Mo) resulted in four new [1.1]metallarenophanes of the general type [{5- tBu-2-(Me 2NCH 2)C 6H 3}E(eta (6)-C 6H 5) 2M] 2 [E = Al, M = Cr ( 4a); E = Ga, M = Cr ( 4b); E = Al, M = Mo ( 5a); E = Ga, M = Mo ( 5b)]. 2a, 4a, b, and 5a, b have been structurally characterized by single-crystal analysis [ 2a.1/2C 6H 12: C 48H 56Al 2Cr 2N 2, monoclinic, P2 1/ c, a = 9.9117(9) A, b = 19.9361(16) A, c = 10.638(2) A, alpha = 90 degrees , beta = 112.322(5) degrees , gamma = 90 degrees , Z = 2; 4a.2C 6H 6: C 62H 72Al 2Cr 2N 2, monoclinic, P2 1/ c, a = 10.9626(9) A, b = 19.3350(18) A, c = 12.4626(9) A, alpha = 90 degrees , beta = 100.756(5) degrees , gamma = 90 degrees , Z = 2; 4b.2C 6H 6: C 62H 72Cr 2Ga 2N 2, monoclinic, P2 1/ c, a = 10.8428(2) A, b = 19.4844(4) A, c = 12.4958(2) A, alpha = 90 degrees , beta = 100.6187 degrees , gamma = 90 degrees , Z = 2; 5a.2C 6H 6: C 62H 72Al 2Mo 2N 2, triclinic, P1, a = 10.4377(4) A, b = 11.6510(4) A, c = 11.6514(4) A, alpha = 73.545(3) degrees , beta = 89.318(2) degrees , gamma = 76.120(2) degrees , Z = 1; 5b.2C 6H 6: C 62H 72Ga 2Mo 2N 2, triclinic, P1, a = 10.3451(5) A, b = 11.6752(6) A, c = 11.6900(5) A, alpha = 73.917(3) degrees , beta = 89.550(3) degrees , gamma = 76.774(2) degrees , Z = 1]. All five [1.1]metallarenophanes 2a, 4a, b, and 5a, b crystallize as anti isomers with both Me 2N donor groups in exo positions ( C i point group symmetry). The new [1.1]metallarenophanes show NMR spectra that can be interpreted as being caused by time-averaged C 2 h symmetrical species, which is consistent with the findings of their molecular structures in the solid state. Variable-temperature (1)H NMR measurements for 4a, b and 5a, b (500 MHz; -90 to 90 degrees C) revealed only peak broadening in the lower temperature range of -70 to -90 degrees C. (1)H NMR saturation transfer difference experiments did not show an expected anti-to-anti isomerization, rendering the new [1.1]metallacyclophanes rigid on the NMR time scale. Electrochemical measurements were performed for 4a, b and 5a, b. However, reproducible cyclic voltammograms could only be obtained for the two gallium species 4b and 5b, revealing the expected weak communication between the two transition-metal atoms in both compounds (class II).

  19. Word Criticality Analysis. MOS: 67N. Skill Levels 1 & 2

    DTIC Science & Technology

    1981-09-01

    12 1 , lat 0.. 71N 4 1 s,1 󈧅 119 *I .!Ill4 r ITr L34 U., p I*. 1, r-*44,1I6 C. I ", il. TD %T i - 96’ !04- 2,1 -i: l st a64 1104 121! tio 2...14 1’.1 !$04 4:4 11.1* :74 :’~ ~4 te 4 , 4?. 4.. 7 ., !:j-q1 , **)4 1Q3 *2 .1 .~ 4134 . 1.,’ 4- 1 41st -74 Ott. 󈧒 *4 . ,4 4,7Y t 1 46520 n190 37.1

  20. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 3. (Beachy Lumber Co.-Campanova, Richard MD)

    DTIC Science & Technology

    1989-01-01

    34ᝰ >w 00 C In --4 C4 -ONN4r- N0-0 11 a M-0 cg< i 1.10 -4 l 9 1 L go ~t00 -40 B LA. ZEZ Z Z Z Z Z Z Z ZZ Z L to01000 z 2 Z0ZZZZZZZZ, (00~t II0. O)41...00 0) 0) 07 ’) n N0) C) 0) 44r- 0 M’ U.n U dw01 44 I -4 000 0OC 0D 0 00 0 0 Is4 ( 9 O J WIn 114IC tax H UJ WC) :14 H WCJ 44 2Z2 2 Z 22 z Z z H 000 4’ M0...4 -4-4 m -4 .- 4 .- 4 -4 -4 -4 -4 -4 404 4- 4W 0000 WWWWWW C(((0000(( u0 N - (0 ) -0)0) 0000 ~--CL If to I 0000 W 4 00000000to "D 00 MC0 -4 .- 4 . 9

  1. Bursaphelenchus xylophilus is killed by homologues of 2-(1-undecyloxy)-1-ethanol

    NASA Astrophysics Data System (ADS)

    Kim, Junheon; Lee, Sang-Myeong; Park, Chung Gyoo

    2016-07-01

    2-(1-Undecyloxy)-1-ethanol, monochamol, is a male-produced aggregation pheromone of the Monochamus species, which are efficient vectors of the pine wood nematode (PWN), Bursaphelenchus xylophilus, which cause devastating damage to pines worldwide. The nematicidal activity of synthetic monochamol and its homologues (ROEtOH: R = C7-C13) were investigated to find potential alternatives to the currently used PWN control agents abamectin and emamectin. Compounds with C7-C13 chain length alkyl groups exhibited 100% nematicidal activity at a concentration of 1000 mg/L. At a concentration of 100 mg/L, 2-(1-nonyloxy)-1-ethanol (C9OEtOH), 2-(1-decyloxy)-1-ethanol (C10OEtOH), 2-(1-undecyloxy)-1-ethanol (C11OEtOH), and 2-(1-dodecyloxy)-1-ethanol (C12OEtOH) showed 100% nematicidal activity, but the others showed weaker activities. C11OEtOH showed similar nematicidal activity to abamectin in terms of LD90 values, which were 13.30 and 12.53 mg/L, respectively. However, C9OEtOH, C10OEtOH, and C12OEtOH (LC90 values: 53.63, 38.18, and 46.68 mg/L, respectively) were less effective than C11OEtOH and abamectin. These results indicate that monochamol could be an effective alternative agent against PWN. The relationship of insecticidal and nematicidal activity to different carbon chain lengths in compounds is discussed.

  2. Structure and electrical properties of a one-dimensional polymeric silver thiosaccharinate complex with argentophilic interactions.

    PubMed

    Dennehy, Mariana; Amo-Ochoa, Pilar; Freire, Eleonora; Suárez, Sebastián; Halac, Emilia; Baggio, Ricardo

    2018-02-01

    Among the potential applications of coordination polymers, electrical conductivity ranks high in technological interest. We report the synthesis, crystal structure and spectroscopic analysis of an Ag I -thiosaccharinate one-dimensional coordination polymer {systematic name: catena-poly[[[aquatetrakis(μ 3 -1,1-dioxo-1,2-benzisothiazole-3-thiolato-κ 3 N:S 3 :S 3 )tetrasilver(I)]-μ 2 -4,4'-(propane-1,3-diyl)dipyridine-κ 2 N:N'] dimethyl sulfoxide hemisolvate]}, {[Ag 4 (C 7 H 4 NO 2 S 2 ) 4 (C 13 H 14 N 2 )(H 2 O)]·0.5C 2 H 6 OS} n , with the 4,4'-(propane-1,3-diyl)dipyridine ligand acting as a spacer. A relevant feature of the structure is the presence of an unusually short Ag...Ag distance of 2.8306 (9) Å, well within the range of argentophilic interactions, confirmed experimentally as such by a Raman study on the low-frequency spectrum, and corroborated theoretically by an Atoms in Molecules (AIM) analysis of the calculated electron density. Electrical conductivity measurements show that this complex can act as a semiconductor with moderate conductivity.

  3. Statistics on Aircraft Gas Turbine Engine Rotor Failures That Occurred in U.S. Commercial Aviation during 1987

    DTIC Science & Technology

    1991-01-01

    17C, 15 NFG 1.7939 CFMI CFM56 0 NC, 3 C, 11 NFG 1.5600 : GARRETT TFE731 .0 NC, 2C, 2 NFG 1.4643 ALSN 250C 1 NC, 11 C, 20 NFG 1.3349 RR RS211 0 NC. 4...10 14 3.0 0.0 7.5 10.5 PW2037/2040 111 0.3206 4 0 0 4 12.5 0.0 0.0 12.5 SPEY 178 0.3573 6 0 5 11 16.8 0.0 14.0 30.8 TFE731 3697 1.5600 2 0 2 4 1.3 0.0...JT15D/No.1 F D 7 NC 3 870609136 GL62 550 JT15D T B 7 C 10 870930017 GL62 LEAR 35 TFE731 T B 7 C 1 870908097 GL19 G50 TFE731 T B 7 C 5 870421035 GL08 LEAR

  4. Structural models of increasing complexity for icosahedral boron carbide with compositions throughout the single-phase region from first principles

    NASA Astrophysics Data System (ADS)

    Ektarawong, A.; Simak, S. I.; Alling, B.

    2018-05-01

    We perform first-principles calculations to investigate the phase stability of boron carbide, concentrating on the recently proposed alternative structural models composed not only of the regularly studied B11Cp (CBC) and B12(CBC), but also of B12(CBCB) and B12( B4 ). We find that a combination of the four structural motifs can result in low-energy electron precise configurations of boron carbide. Among several considered configurations within the composition range of B10.5C and B4C , we identify in addition to the regularly studied B11Cp (CBC) at the composition of B4C two low-energy configurations, resulting in a new view of the B-C convex hull. Those are [B12 (CBC)]0.67[B12(B4)] 0.33 and [B12 (CBC)]0.67[ B12 (CBCB)]0.33, corresponding to compositions of B10.5C and B6.67C , respectively. As a consequence, B12(CBC) at the composition of B6.5C , previously suggested in the literature as a stable configuration of boron carbide, is no longer part of the B -C convex hull. By inspecting the electronic density of states as well as the elastic moduli, we find that the alternative models of boron carbide can provide a reasonably good description for electronic and elastic properties of the material in comparison with the experiments, highlighting the importance of considering B12(CBCB) and B12( B4 ), together with the previously proposed B11Cp (CBC) and B12(CBC), as the crucial ingredients for modeling boron carbide with compositions throughout the single-phase region.

  5. Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis.

    PubMed

    Fu, Liping; Liu, Linwen; Zhang, Jinming; Xu, Baixuan; Fan, Yong; Tian, Jiahe

    2014-11-01

    To identify the optimal time window for capturing perfusion information from early (11)C-PIB imaging frames (perfusion PIB, (11)C-pPIB) and to compare the performance of (18)F-FDG PET and "dual biomarker" (11)C-PIB PET [(11)C-pPIB and amyloid PIB ((11)C-aPIB)] for classification of AD, MCI and CN subjects. Forty subjects (14 CN, 12 MCI and 14 AD patients) underwent (18)F-FDG and (11)C-PIB PET studies. Pearson correlation between the (18)F-FDG image and sum of early (11)C-PIB frames was maximised to identify the optimal time window for (11)C-pPIB. The classification power of imaging parameters was evaluated with a leave-one-out validation. A 7-min time window yielded the highest correlation between (18)F-FDG and (11)C-pPIB. (11)C-pPIB and (18)F-FDG images shared a similar radioactive distribution pattern. (18)F-FDG performed better than (11)C-pPIB for the classification of both AD vs. CN and MCI vs. CN. (11)C-pPIB + (11)C-aPIB and (18)F-FDG + (11)C-aPIB yielded the highest classification accuracy for the classification of AD vs. CN, and (18)F-FDG + (11)C-aPIB had the best classification performance for the classification of MCI vs. C-pPIB could serve as a useful biomarker of rCBF for measuring neural activity and improve the diagnostic power of PET for AD in conjunction with (11)C-aPIB. (18)F-FDG and (11)C-PIB dual-tracer PET examination could better detect MCI. • Dual-tracer PET examination provides neurofunctional and neuropathological information for AD diagnosis. • The identified optimal 11C-pPIB time frames had highest correlation with 18F-FDG. • 11C-pPIB images shared a similar radioactive distribution pattern with 18F-FDG images. • 11C-pPIB can provide neurofunctional information. • Dual-tracer PET examination could better detect MCI.

  6. Purification and crystal growth of NPB via imidazolium based ionic liquids

    NASA Astrophysics Data System (ADS)

    Oh, Yong-Taeg; Shin, Dong-Chan

    2018-04-01

    Here we report the production of high purity and crystallinity organic electronic material of NPB (N,N‧-Di-[(1-naphthyl)-N,N‧-diphenyl]-1,1‧-biphenyl-4,4‧-diamine (C44H32N2) through solution recrystallization within imidazolium based ionic liquids. When low purity NPB was recrystallized at 170 °C within C8MIM[TFSI], its purity was drastically improved from 82% to 99.92%. These recrystallized NPB crystals showed 0.040° FWHM (Full Width Half Maximum) of X-ray (1 1 1) diffraction peak. Such small FWHM angle indicates single-crystal like crystallinity. Initial NPB powder was dissolved at 100 °C and recrystallized at temperature above 110 °C. At higher temperature of 170 °C, a small number of bigger crystals were formed compared to those at 110 °C. This can be well explained by the classical nucleation and growth theory. Therefore, solution recrystallization process using ionic liquid might be promising for mass production of organic electronic materials by replacing the widely-used sublimation purification method.

  7. Step Stress Testing of Receiver/Transmitter Units. Part 1

    DTIC Science & Technology

    1993-02-01

    voltage reading taken must be multiplied by 10 (as instructed on the test box) to convert to the proper milliampere (mA) reading. D- 16 018 CAUTIONII...INTERVALs4 and 5 above using VARIABLEs below. INTERVAL 6&7 8&9 10&11 12&13 14&15 16 &17 18&19 20&21 FINALVAL (oC) 85 94 102 111 119 127 135 143 INTERVAL...22.Z deg. ch~ 6 22. d. ~ch- 69 2.3ds ch- 09 11.5dgC ch- 16 22.2 d.~ _h 9 2. oSc 0 2. eg;S ch 1 2. oCch- 1a 22.3 d92_C Ch, 11 2. de;C ch- 12 22.2 dog-C

  8. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Federal Environmental Services - General Hospital Corporation)

    DTIC Science & Technology

    1993-01-01

    4 I COON 4 X- IN IM COO 44 It~ LILA 55 ’)ýl LL - L W I -LLW - UUU-ýý .ý -UL..-- gL lA -40-U- (t’- 0-4-4 N CLIII S O0 I40 0x c> 4Nof-4-.) 05 CI OO 444...000 0- OC C CO C : 1 0-4-4 If 33 33:7 t3::t ;r333333:333r 333 3333: :r --3l3c c 3 c 33 3 :3 ofw 4. I000) i5 55 0 00) it so uC) 11 MM o 00...2Zzzzzz22zzzz2z22Zzzzzzzzzzzzzzz2222 z222zzzz 2 if 1C.)0-4 11 22zzmZZZZZZZZzzzz2zzzz2zz2zzzz~zzzzzzzzz2zz Z 55 C-4(10 II NN N NmJN N N N N :5 -4 1 CO-4NO 51 5 IO W-4NCO 19 it CO-4NCO

  9. Fe-Mg substitution in aluminate spinels: effects on elastic properties investigated by Brillouin scattering

    NASA Astrophysics Data System (ADS)

    Bruschini, Enrico; Speziale, Sergio; Bosi, Ferdinando; Andreozzi, Giovanni B.

    2018-03-01

    We investigated by a multi-analytical approach (Brillouin scattering, X-ray diffraction and electron microprobe) the dependence of the elastic properties on the chemical composition of six spinels in the series (Mg1-x ,Fe x )Al2O4 (0 ≤ x ≤ 0.5). With the exception of C 12, all the elastic moduli (C 11, C 44, K S0 and G) are insensitive to chemical composition for low iron concentration, while they decrease linearly for higher Fe2+ content. Only C 12 shows a continuous linear increase with increasing Fe2+ across the whole compositional range under investigation. The high cation disorder showed by the sample with x = 0.202 has little or no influence on the elastic parameters. The range 0.202 < x < 0.388 bounds the percolation threshold (p c) for nearest neighbor interaction of Fe in the cation sublattices of the spinel structure. Below x = 0.202, the iron atoms are diluted in the system and far from each other, and the elastic moduli are nearly constant. Above x = 0.388, Fe atoms form extended interconnected clusters and show a cooperative behavior thus affecting the single-crystal elastic moduli. The elastic anisotropy largely increases with the introduction of Fe2+ in substitution of magnesium in spinel. This behavior is different with respect to other spinels containing transition metals such as Mn2+ and Co2+.

  10. Identifying Older Adults with Serious Illness: A Critical Step toward Improving the Value of Health Care.

    PubMed

    Kelley, Amy S; Covinsky, Kenneth E; Gorges, Rebecca J; McKendrick, Karen; Bollens-Lund, Evan; Morrison, R Sean; Ritchie, Christine S

    2017-02-01

    To create and test three prospective, increasingly restrictive definitions of serious illness. Health and Retirement Study, 2000-2012. We evaluated subjects' 1-year outcomes from the interview date when they first met each definition: (A) one or more severe medical conditions (Condition) and/or receiving assistance with activities of daily living (Functional Limitation); (B) Condition and/or Functional Limitation and hospital admission in the last 12 months and/or residing in a nursing home (Utilization); and (C) Condition and Functional Limitation and Utilization. Definitions are increasingly restrictive, but not mutually exclusive. Of 11,577 eligible subjects, 5,297 met definition A; 3,151 definition B; and 1,447 definition C. One-year outcomes were as follows: hospitalization 33 percent (A), 44 percent (B), 47 percent (C); total average Medicare costs $20,566 (A), $26,349 (B), and $30,828 (C); and mortality 13 percent (A), 19 percent (B), 28 percent (C). In comparison, among those meeting no definition, 12 percent had hospitalizations, total Medicare costs averaged $7,789, and 2 percent died. Prospective identification of older adults with serious illness is feasible using clinically accessible criteria and may be a critical step toward improving health care value. These definitions may aid clinicians and health systems in targeting patients who could benefit from additional services. © Health Research and Educational Trust.

  11. Large-Scale Separation and Wake Closure/Reattachment - The Cascade Problem,

    DTIC Science & Technology

    1983-05-01

    7.3b-d) gives, for all x > xsep K (X) = u(u-l)dy + 1se (11-7.7) 44 UTRC83-13 where Isep is the integrated momentum deficit at separation, from (II...with c1 = (K: o 2/b - Isep /b) positive. So (II-7.5a) requires the underlying form -g ~-1/2_ +- g go (G) + x -1()+..+x 2 (a)+ .... (II-7.10a) for g

  12. Ultrasound-assisted synthesis of santalbic acid and a study of triacylglycerol species in Santalum album (Linn.) seed oil.

    PubMed

    Lie Ken Jie, M S; Pasha, M K; Ahmad, F

    1996-10-01

    Methyl ricinoleate (1) was treated with bromine and the dibromo derivative (2) was reacted with ethanolic KOH under ultrasonic irradiation to give 12-hydroxy-octadec-9-ynoic acid upon acidification with dil. HCI. The latter compound was methylated with BF3/methanol to give methyl 12-hydroxy-octadec-9-ynoate (3). Compound 3 was treated with methanesulfonyl chloride in the presence of triethylamine in CH2Cl2 to give methyl 12-mesyloxy-octadec-9-ynoate (4). Reaction of methyl 12-mesyloxy-octadec-9-ynoate with aqueous KOH under ultrasonic irradiation (20 kHz) gave (11E)-octadecen-9-ynoic acid (5, santalbic acid, 40%) and (11Z)-octadecen-9-ynoic acid (6, 60%) on acidification with dil. HCI. These isomers were separated by urea fractionation. The 13C nuclear magnetic resonance (NMR) spectroscopic properties of the methyl ester and the triacylglycerol (TAG) esters of these enynoic fatty acid isomers were studied. The carbon shifts of the unsaturated carbon nuclei of the methyl ester of the E-isomer were unambiguously assigned as 88.547 (C-9), 79.287 (C-10), 109.760 (C-11), and 143.450 (C-12) ppm, while the unsaturated carbon shifts of the (Z)-enynoate isomer appeared at 94.277 (C-9), 77.561 (C-10), 109.297 (C-11), and 142.668 (C-12) ppm. In the 13C NMR spectral analysis of the TAG molecules of type AAA containing either the (Z)- or (E)-enyne fatty acid, the C-1 to C-6 carbon atoms on the alpha- and beta-acyl positions were differentiated. The unsaturated carbon atoms in the alpha- and beta-acyl chains were also resolved into two signals except that of the C-11 olefinic carbon. Sandal (Santalum album) wood seed oil (a source of santalbic acid) was separated by silica chromatography into three fractions. The least polar fraction (7.2 wt%) contained TAG which had a random distribution of saturated and unsaturated fatty acids, of which oleic acid (69%) was the predominant component. The second fraction (3.8 wt%) contained santalbic acid (58%) and oleic acid (28%) together with some other normal fatty acids. Santalbic acid in this fraction was found in both the alpha- and beta-acyl positions of the glycerol "backbone." The most polar fraction (89 wt%) consisted of TAG containing santalbic acid only. The distribution of the various fatty acids on the glycerol "backbone" was supported by the results from the 13C NMR spectroscopic analysis.

  13. 40 CFR 52.2020 - Identification of plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...)(131). Section 126.303(a) Compliance and test methods 11/1/97 6/8/98, 63 FR 31116 (c)(131). Subchapter....107 Variances 10/5/02 12/8/04, 69 FR 70893 (c)(229). Section 130.108 Test procedures 10/5/02 12/8/04... 70895 (c)(230). Section 130.414 Modification of variance 10/11/08 10/18/10, 75 FR 63717. TEST METHODS...

  14. 30 CFR 915.15 - Approval of Iowa regulatory program amendments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

  15. 30 CFR 915.15 - Approval of Iowa regulatory program amendments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

  16. 30 CFR 915.15 - Approval of Iowa regulatory program amendments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

  17. 30 CFR 915.15 - Approval of Iowa regulatory program amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

  18. 30 CFR 915.15 - Approval of Iowa regulatory program amendments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

  19. New developments of 11C post-accelerated beams for hadron therapy and imaging

    NASA Astrophysics Data System (ADS)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate pristine Bragg Peaks of 11C, in order to compare its performance with 12C, in the context of hadron therapy.

  20. Commercial sheep flocks--fatty acid and fat-soluble antioxidant composition of milk and cheese related to changes in feeding management throughout lactation.

    PubMed

    Valdivielso, Izaskun; Bustamante, María Ángeles; Buccioni, Arianna; Franci, Oreste; Ruiz de Gordoa, Juan Carlos; de Renobales, Mertxe; Barron, Luis Javier R

    2015-08-01

    Fatty acids (FAs), tocopherols and retinoids were analysed in raw milk and cheese from six commercial sheep flocks monitored from early lactation in winter to late lactation in summer. In winter, animals received concentrate and forage indoors; in early spring, animals grazed part-time on cultivated or natural valley grasslands; and from mid spring on, animals were kept outdoors constantly on mountain natural pastures. Mountain grazing in late lactation significantly increased the amount of healthy desirable unsaturated FAs such as C18:1t11 (VA), C18:2c9t11 (RA), C18:2t11c13, C18:3c9c12c15 (ALA) and C20:5c5c8c11c14c17 (EPA), and those of α-tocopherol and α-tocotrienol of milk and cheese. Stepwise discriminant analysis was applied to classify cheese samples according to seasonal feeding management. The multivariate approach was able to discriminate beyond doubt mountain cheeses from those of indoor feeding and part-time valley grazing.

  1. Kinetics of the R + NO2 reactions (R = i-C3H7, n-C3H7, s-C4H9, and t-C4H9) in the temperature range 201-489 K.

    PubMed

    Rissanen, Matti P; Arppe, Suula L; Eskola, Arkke J; Tammi, Matti M; Timonen, Raimo S

    2010-04-15

    The bimolecular rate coefficients of four alkyl radical reactions with NO(2) have been measured in direct time-resolved experiments. Reactions were studied under pseudo-first-order conditions in a temperature-controlled tubular flow reactor coupled to a laser photolysis/photoionization mass spectrometer (LP-PIMS). The measured reaction rate coefficients are independent of helium bath gas pressure within the experimental ranges covered and exhibit negative temperature dependence. For i-C(3)H(7) + NO(2) and t-C(4)H(9) + NO(2) reactions, the dependence of ordinate (logarithm of reaction rate coefficients) on abscissa (1/T or log(T)) was nonlinear. The obtained results (in cm(3) s(-1)) can be expressed by the following equations: k(n-C(3)H(7) + NO(2)) = ((4.34 +/- 0.08) x 10(-11)) (T/300 K)(-0.14+/-0.08) (203-473 K, 1-7 Torr), k(i-C(3)H(7) + NO(2)) = ((3.66 +/- 2.54) x 10(-12)) exp(656 +/- 201 K/T)(T/300 K)(1.26+/-0.68) (220-489 K, 1-11 Torr), k(s-C(4)H(9) + NO(2)) = ((4.99 +/- 0.16) x 10(-11))(T/300 K)(-1.74+/-0.12) (241-485 K, 2 - 12 Torr) and k(t-C(4)H(9) + NO(2)) = ((8.64 +/- 4.61) x 10(-12)) exp(413 +/- 154 K/T)(T/300 K)(0.51+/-0.55) (201-480 K, 2-11 Torr), where the uncertainties shown refer only to the 1 standard deviations obtained from the fitting procedure. The estimated overall uncertainty in the determined bimolecular rate coefficients is about +/-20%.

  2. The improved mechanical properties of β-CaSiO3 bioceramics with Si3N4 addition.

    PubMed

    Pan, Ying; Zuo, Kaihui; Yao, Dongxu; Yin, Jinwei; Xin, Yunchuan; Xia, Yongfeng; Liang, Hanqin; Zeng, Yuping

    2015-03-01

    The motivation of this study is to investigate the effect of Si3N4 addition on the sinterability of β-CaSiO3 ceramics. β-CaSiO3 ceramics with different content of Si3N4 were prepared at the sintering temperature ranging from 1000°C to 1150°C. The results showed that Si3N4 can be successfully used as sintering additive by being oxidized to form SiO2. The β-CaSiO3 ceramics with 3wt% Si3N4 sintered at 1100°C revealed flexural strength, hardness and fracture toughness of 157.2MPa, 4.4GPa and 2.3MPam(1/2) respectively, which was much higher than that of pure β-CaSiO3 ceramics (41.1MPa, 1.0GPa, 1.1MPam(1/2)). XRD analysis and SEM observation indicated that the main phase maintained to be β-phase after sintering. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. cAMP enhances BMP2-signaling through PKA and MKP1-dependent mechanisms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ghayor, Chafik; Ehrbar, Martin; Miguel, Blanca San

    2009-04-03

    Recent studies suggest that the elevation of intracellular cyclic adenosine monophosphate (cAMP) and the activation of the protein kinase A regulate BMP-induced osteogenesis. However, the precise mechanisms underlying the enhancing effect of cAMP on BMP2 signaling were not completely revealed. In this study we investigated the effect of elevated cAMP level and PKA activation on the BMP2-induced osteoblastic differentiation in pluripotent C2C12 cells. Alkaline phosphatase activity and its mRNA were consistently induced by BMP2 treatment. The pretreatment of C2C12 cells with Forskolin, a cAMP generating agent, dbcAMP, an analogue of cAMP, or IBMX (3-isobutyl 1-methyl xanthine), and a nonspecific inhibitormore » of phosphodiesterases elicited further activation of alkaline phosphatase. Furthermore, elevated intracellular cAMP level increased BMP2-induced MKP1. On the other hand, BMP2-induced Erk phosphorylation (p44/p42) and cell proliferation were suppressed in the presence of cAMP. Thus, cAMP might enhance BMP2-induced osteoblastic differentiation by a MKP1-Erk-dependent mechanism.« less

  4. Monitoring of selected non-ionic surfactants in river water by liquid chromatography-tandem mass spectrometry.

    PubMed

    Zembrzuska, Joanna; Budnik, Irena; Lukaszewski, Zenon

    2016-03-15

    Alcohol ethoxylates (AEs) are a significant component of the non-ionic surfactant (NS) flux discharged into surface water. Due to the polydispersity of the majority of NS, they are easily recognizable by their 'fingerprints', i.e. a series of mass peaks which differ by m/z = 44, namely the m/z of a single oxyethylene subunit. Dodecanol ethoxylates (C12EOx) represent AEs from both renewable and petrochemical sources. Therefore, C12Ex are suitable fingerprints of NS in the aquatic environment. The aim of this work was to develop an LC-MS/MS method suitable for AE monitoring in river water. River water samples taken from the River Warta in Poznan (Poland) were extracted with ethyl acetate, evaporated, reconstituted in the mobile phase and processed by the LC - Multistage MS procedure (LC-MS/MS) using optimum multiple reaction monitoring (MRM). The method of multiple standard additions was used for the evaluation of each AE fingerprint concentration. The concentration of C12EOx having 2-9 oxyethylene subunits was determined. Standards for higher C12EOx are not yet available. The developed method offers an LOD of between 1 and 9 ng L(-1), and is suitable for the monitoring of NS fingerprints in river water. The range of C12EO2-9 concentrations determined in the River Warta varied within two orders of magnitude in all cases. The lowest determined concentration was 17 ± 1 ng L(-1), while the highest was 2.6 ± 0.14 μg L(-1). The total concentration of C12EO2-C12EO9 homologues varied between 1.4 and 11.2 μg L(-1). A relatively high concentration of short-chained homologues (2-5 oxyethylene subunits) was observed in the investigated river water. This provides evidence of a biodegradation pathway involving the gradual shortening of the AE oxyethylene chain. Distinct evidence was also obtained of unregulated NS discharges into the river. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors.

    PubMed

    Hwang, D R; Kegeles, L S; Laruelle, M

    2000-08-01

    Imaging neuroreceptors with radiolabeled agonists might provide valuable information on the in vivo agonist affinity states of receptors of interest. We report here the radiosynthesis, biodistribution in rodents, and imaging studies in baboons of [(11)C]-labeled (-)-N-propyl-norapomorphine [(-)-NPA]. (-)-[(11)C]NPA was prepared by reacting norapomorphine with [(11)C]propionyl chloride and a lithium aluminum hydride reduction. [(11)C]Propionyl chloride was prepared by reacting [(11)C]CO(2) with ethylmagnesium bromide, followed by reacting with phthaloyl chloride. The radiochemical yield of (-)-[(11)C]NPA was 2.5% at end of synthesis (EOS), and the synthesis time was 60 min. The specific activity was 1700+/-1900 mCi/micromol ( N=7; ranged 110-5200 mCi/micromol at EOS). Rodent biodistribution studies showed high uptake of [(11)C](-)-NPA in D(2) receptor-rich areas, and the striatum/cerebellum ratios were 1.7, 3.4, and 4.4 at 5 min, 30 min, and 60 min postinjection, respectively. Pretreating the animals with haloperidol (1 mg/kg) decreased the striatum/cerebellum ratio at 30 min postinjection to 1.3. (-)-[(11)C]NPA was also evaluated via baboon positron emission tomography (PET) studies. Under control conditions ( N=4), rapid uptake of the tracer was observed and the striatum/cerebellum ratio reached 2.86+/-0.15 at 45 min postinjection. Following haloperidol pretreatment (0.2 mg/kg IV), the striatum/cerebellum ratio was 1.29 at 45 min postinjection. The result demonstrated the existence of specific binding of this new tracer to the D(2) receptor. To our knowledge, the current finding of a striatum/cerebellum ratio of 2.8 in baboon was the highest reported with a radiolabeled D(2) agonist. (-)-[(11)C]NPA is a promising new D(2) agonist PET tracer for probing D(2) receptors in vivo using PET.

  6. Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity

    PubMed Central

    Cortes, Leonel A.; Castro, Lorena; Pesce, Bárbara; Maya, Juan D.; Ferreira, Jorge; Castro-Castillo, Vicente; Parra, Eduardo; Jara, José A.; López-Muñoz, Rodrigo

    2015-01-01

    Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. These drugs have limited efficacy and frequently induce adverse effects, limiting their usefulness. Consequently, new drugs must be found. In this study, we demonstrated the in vitro trypanocidal effects of a series of four gallic acid derivatives characterized by a gallate group linked to a triphenylphosphonium (TPP+) moiety (a delocalized cation) via a hydrocarbon chain of 8, 10, 11, or 12 atoms (TPP+-C8, TPP+-C10, TPP+-C11, and TPP+-C12, respectively). We analyzed parasite viability in isolated parasites (by MTT reduction and flow cytometry) and infected mammalian cells using T. cruzi Y strain trypomastigotes. Among the four derivatives, TPP+-C10 and TPP+-C12 were the most potent in both models, with EC50 values (in isolated parasites) of 1.0 ± 0.6 and 1.0 ± 0.7 μM, respectively, and were significantly more potent than nifurtimox (EC50 = 4.1 ± 0.6 μM). At 1 μM, TPP+-C10 and TPP+-C12 induced markers of cell death, such as phosphatidylserine exposure and propidium iodide permeabilization. In addition, at 1 μM, TPP+-C10 and TPP+-C12 significantly decreased the number of intracellular amastigotes (TPP+-C10: 24.3%, TPP+-C12: 19.0% of control measurements, as measured by DAPI staining) and the parasite’s DNA load (C10: 10%, C12: 13% of control measurements, as measured by qPCR). Based on the previous mode of action described for these compounds in cancer cells, we explored their mitochondrial effects in isolated trypomastigotes. TPP+-C10 and TPP+-C12 were the most potent compounds, significantly altering mitochondrial membrane potential at 1 μM (measured by JC-1 fluorescence) and inducing mitochondrial transition pore opening at 5 μM. Taken together, these results indicate that the TPP+-C10 and TPP+-C12 derivatives of gallic acid are promising trypanocidal agents with mitochondrial activity. PMID:26317199

  7. Biodegradation of HT Agent from an Assembled Chemical Weapons Assessment (ACWA) Projectile Washout Study

    DTIC Science & Technology

    2006-09-01

    SVOC Dithiane isomer 170 J u1/I SVOC Hexadecenoic acid , Z- 11- JN 95 ug// SVOC Naphtho[2,3-b]thiophene, 4,9-dimethyl- 650 JN ug/l SVOC Oxirane, 2,3...were operated at ambient room temperature (23 to 25 ’C). Because the biodegradation of TDG produces sulfuric acid , pH control is essential. A pH... acid 3.00 NaOH Enough to allow Nitrilotriacetic acid to dissolve MgC12 4H20 6.95 MnC12 0.66 FeC12 0.23 CaC12 2H 20 0.07 COC12 6H 20 0.10 ZnC12

  8. Buckminsterfullerene's (C60) octanol-water partition coefficient (Kow) and aqueous solubility.

    PubMed

    Jafvert, Chad T; Kulkarni, Pradnya P

    2008-08-15

    To assess the risk and fate of fullerene C60 in the environment, its water solubility and partition coefficients in various systems are useful. In this study, the log Kow of C60 was measured to be 6.67, and the toluene-water partition coefficient was measured at log Ktw = 8.44. From these values and the respective solubilities of C60 in water-saturated octanol and water-saturated toluene, C60's aqueous solubility was calculated at 7.96 ng/L(1.11 x 10(-11) M) for the organic solvent-saturated aqueous phase. Additionally, the solubility of C60 was measured in mixtures of ethanol-water and tetrahydrofuran-water and modeled with Wohl's equation to confirm the accuracy of the calculated solubility value. Results of a generator column experiment strongly support the hypothesis that clusters form at aqueous concentrations below or near this calculated solubility. The Kow value is compared to those of other hydrophobic organic compounds, and bioconcentration factors for C60 were estimated on the basis of Kow.

  9. Subthreshold parallel pumping experiments on the quasi one-dimensional S = {1}/{2} ferromagnets [C 6H 11NH 3]CuBr 3 and [C 6H 11NH 3]CuCl 3

    NASA Astrophysics Data System (ADS)

    Hoogerbeets, R.; Wiegers, S. A. J.; Van Duyneveldt, A. J.

    1985-04-01

    Subthreshold parallel pumping experiments on [C 6H 11NH 3]CuBr 3 (abbreviated as CHAB) and [C 6H 11NH 3]CuCl 3 (CHAC) at 9.6 and 18.3 GHz are reported. It is shown that the experimental results can be explained using the values of the parameters as have been obtained from previously reported FMR measurements.

  10. Elasticity of phase-Pi (Al3Si2O7(OH)3) - A hydrous aluminosilicate phase

    NASA Astrophysics Data System (ADS)

    Peng, Ye; Mookherjee, Mainak; Hermann, Andreas; Bajgain, Suraj; Liu, Songlin; Wunder, Bernd

    2017-08-01

    Phase-Pi (Al3Si2O7(OH)3) is an aluminosilicate hydrous mineral and is likely to be stable in hydrated sedimentary layers of subducting slabs. Phase-Pi is likely to be stable between the depths of 60 and 200 km and is likely to transport water into the Earth's interior. Here, we use first principles simulations based on density functional theory to explore the crystal structure at high-pressure, equation of state, and full elastic stiffness tensor as a function of pressure. We find that the pressure volume results could be described by a finite strain fit with V0 , K0 , and K0‧ being 310.3 Å3, 133 GPa, and 3.6 respectively. At zero pressure, the full elastic stiffness tensor shows significant anisotropy with the diagonal principal components C11 , C22 , and C33 being 235, 292, 266 GPa respectively, the diagonal shear C44 , C55 , and C66 being 86, 92, and 87 GPa respectively, and the off-diagonal stiffness C12 , C13 , C14 ,C15 , C16 , C23 , C24 , C25 , C26 , C34 , C35 , C36 , C45 , C46 , and C56 being 73, 78, 6, -30, 15, 61, 17, 2, 1, -13, -15, 6, 3, 1, and 3 GPa respectively. The zero pressure, shear modulus, G0 and its pressure derivative, G0 ‧ are 90 GPa and 1.9 respectively. Upon compression, hydrogen bonding in phase-Pi shows distinct behavior, with some hydrogen bonds weakening and others strengthening. The latter eventually undergo symmetrization, at pressure greater (>40 GPa) than the thermodynamic stability of phase-Pi. Full elastic constant tensors indicate that phase-Pi is very anisotropic with AVP ∼22.4% and AVS ∼23.7% at 0 GPa. Our results also indicate that the bulk sound velocity of phase-Pi is slower than that of the high-pressure hydrous aluminosilicate phase, topaz-OH.

  11. Vitamin D. Treatment of Prostate Cancer: The Inhibitory Role of IGFBP-3

    DTIC Science & Technology

    2005-01-01

    cassette, sub-family C (CFTR/MRP), member 6 AA424804 Flag 1.62 2.36 Xeroderma pigmentosum , complementation group C (XPC) AA287323 1.44 1.83 2.25...expressed gene I (POVI) T72067 2.37 7.30 Xeroderma pigmentosum , complementation group C (XPC) AA287323 2.25 11.2 Claudin 4 AA506754 2.21 7.30 UDP...Diego: Academic Press; 2001. in DNA damage response ( xeroderma pigmentosum pp 257-303. compledamentatgerouponse C e r [e 3. Miller GJ. Vitamin D and

  12. Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific.

    PubMed

    Berryhill, Grace E; Miszewski, Susan G; Trott, Josephine F; Kraft, Jana; Lock, Adam L; Hovey, Russell C

    2017-03-01

    We previously reported that the trans-18:2 fatty acid trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) stimulates mammary gland development independent of estrogen and its receptor. Given the negative consequences of dietary trans-fatty acids on various aspects of human health, we sought to establish whether other trans-fatty acids could similarly induce ovary-independent mammary gland growth in mice. Prepubertal BALB/cJ mice were ovariectomized at 21 days of age then were fed diets enriched with cis-9, trans-11 CLA (c9,t11-CLA), or mixtures of trans-18:1 fatty acids supplied by partially hydrogenated sunflower, safflower, or linseed oil. The resultant mammary phenotype was evaluated 3 weeks later and compared to the growth response elicited by t10,c12-CLA, or the defined control diet. Whereas partially hydrogenated safflower oil increased mammary gland weight, none of the partially hydrogenated vegetable oils promoted mammary ductal growth. Similarly, the c9,t11-CLA supplemented diet was without effect on mammary development. Taken together, our data emphasize a unique effect of t10,c12-CLA in stimulating estrogen-independent mammary gland growth manifest as increased mammary ductal area and elongation that was not recapitulated by c9,t11-CLA or the partially hydrogenated vegetable oil diets.

  13. Identification of eQTLs for Hepatic Xbp1s and Socs3 Gene Expression in Mice Fed a High-Fat, High-Caloric Diet

    PubMed Central

    Pasricha, Sarina; Kenney-Hunt, Jane; Anderson, Kristy; Jafari, Nadereh; Hall, Rabea A.; Lammert, Frank; Cheverud, James; Green, Richard M.

    2015-01-01

    Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent form of human hepatic disease and feeding mice a high-fat, high-caloric (HFHC) diet is a standard model of NAFLD. To better understand the genetic basis of NAFLD, we conducted an expression quantitative trait locus (eQTL) analysis of mice fed a HFHC diet. Two-hundred sixty-five (A/J × C57BL/6J) F2 male mice were fed a HFHC diet for 8 wk. eQTL analysis was utilized to identify genomic regions that regulate hepatic gene expression of Xbp1s and Socs3. We identified two overlapping loci for Xbp1s and Socs3 on Chr 1 (164.0–185.4 Mb and 174.4–190.5 Mb, respectively) and Chr 11 (41.1–73.1 Mb and 44.0–68.6 Mb, respectively), and an additional locus for Socs3 on Chr 12 (109.9–117.4 Mb). C57BL/6J-Chr 11A/J/ NaJ mice fed a HFHC diet manifested the A/J phenotype of increased Xbp1s and Socs3 gene expression (P < 0.05), whereas C57BL/6J-Chr 1A/J/ NaJ mice retained the C57BL/6J phenotype. In addition, we replicated the eQTLs on Chr 1 and Chr 12 (LOD scores ≥3.5) using mice from the BXD murine reference panel challenged with CCl4 to induce chronic liver injury and fibrosis. We have identified overlapping eQTLs for Xbp1 and Socs3 on Chr 1 and Chr 11, and consomic mice confirmed that replacing the C57BL/6J Chr 11 with the A/J Chr 11 resulted in an A/J phenotype for Xbp1 and Socs3 gene expression. Identification of the genes for these eQTLs will lead to a better understanding of the genetic factors responsible for NAFLD and potentially other hepatic diseases. PMID:25617409

  14. Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (McKendree W I Co., Inc.-Photon Dynamics, Inc.)

    DTIC Science & Technology

    1993-01-01

    4 0 04l0 O 0(JoCQcj ~ (, j C E ~ ~ ~ ~ ~ ~ ~ ~ c  0 00 44~~4 00eO,. 0zfOt E cm, L44(4𔃾 C0.m04000o0C4.> 4) ,, C, ,0C *4I 0) U IL L05 c=I - Voz ...000 000-40 D .0 0 ~ o0a I0: 0 -K <pap aý 0P0I’a.a’..) Pa~la~al~aa~al (J~a2a~ a .00 PaC~r~Paa~aO~a-’O Pa 4~ ~~~ ~~ w0 IP -I - Oca~f a (P 10 a( 0I’ ’P...5,II 41 a Id 0. 0. EDa DOM12 m 00I0 Qm- Oa 0. i 0 00 mI 00 4 01 NO4 m cu 0-1 C0 C!! 200 I.. 4IOO : N IP , 2 ’ (U)0 4 r1211 a 4444 Im m 0 0 1OZZOO~~i

  15. Underwater Facilities Inspections and Assessments at Philadelphia Naval Shipyard, Philadelphia, Pennsylvania. Volume 1.

    DTIC Science & Technology

    1983-10-01

    NAVAL FACILITIES ENGINEERING COMMAND~ CORPORATION .𔃾CN C 33 pItLAOFLPHI* NAVAL SH4IP-110 PŕiIL -~~NA IA I 1OAQ 4C-14723, C-13041o, C- 13047 4C-1~3046...5ECTION 2 4 8 10 ATI i I 70 30 0 .50SCALE OF FEET GOAHI FCALE CHESAPEAKE DIVISION GRAPIC SALENAVAL FACILITIES ENGINEERING COMMAND C-DLS E.GINEERING...ELEVATION CORE LCC- ATI ~J 45+00 444-50 44+00 493+50 loyo OF V 1 11 FILE’ NV~ 45+0(o / 10 5TA � TIMBER 51NEETIW4& BATTER FILI c 0 - r, - Q Q -Q Q Q -Q- ’~ rP

  16. The cDNA sequence of mouse Pgp-1 and homology to human CD44 cell surface antigen and proteoglycan core/link proteins.

    PubMed

    Wolffe, E J; Gause, W C; Pelfrey, C M; Holland, S M; Steinberg, A D; August, J T

    1990-01-05

    We describe the isolation and sequencing of a cDNA encoding mouse Pgp-1. An oligonucleotide probe corresponding to the NH2-terminal sequence of the purified protein was synthesized by the polymerase chain reaction and used to screen a mouse macrophage lambda gt11 library. A cDNA clone with an insert of 1.2 kilobases was selected and sequenced. In Northern blot analysis, only cells expressing Pgp-1 contained mRNA species that hybridized with this Pgp-1 cDNA. The nucleotide sequence of the cDNA has a single open reading frame that yields a protein-coding sequence of 1076 base pairs followed by a 132-base pair 3'-untranslated sequence that includes a putative polyadenylation signal but no poly(A) tail. The translated sequence comprises a 13-amino acid signal peptide followed by a polypeptide core of 345 residues corresponding to an Mr of 37,800. Portions of the deduced amino acid sequence were identical to those obtained by amino acid sequence analysis from the purified glycoprotein, confirming that the cDNA encodes Pgp-1. The predicted structure of Pgp-1 includes an NH2-terminal extracellular domain (residues 14-265), a transmembrane domain (residues 266-286), and a cytoplasmic tail (residues 287-358). Portions of the mouse Pgp-1 sequence are highly similar to that of the human CD44 cell surface glycoprotein implicated in cell adhesion. The protein also shows sequence similarity to the proteoglycan tandem repeat sequences found in cartilage link protein and cartilage proteoglycan core protein which are thought to be involved in binding to hyaluronic acid.

  17. trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis.

    PubMed

    Cho, Han Jin; Kwon, Gyoo Taik; Park, Jung Han Yoon

    2009-10-01

    Conjugated linoleic acid (CLA), which is naturally present in a variety of foods such as milk fat and the meat of ruminant animals, has been demonstrated to exert chemoprotective effects in several tissues in experimental animals. CLA is a collective term, which denotes one or more positional and geometric isomers of octadecadienoic acid, with cis-9,trans-11 (c9t11) and trans-10,cis-12 CLA (t10c12) being the principal isomers in commercial preparations. We observed previously that physiological levels of CLA inhibited HT-29 cell growth, and the growth inhibitory effects of CLA were attributed to the effect of t10c12, but not c9t11. In the present study, we assessed the mechanisms by which physiological levels of CLA and t10c12 induce apoptosis in HT-29 cells. HT-29 cells were cultured for 3 days in serum-free medium in the presence of various concentrations of CLA (0-20 micromol/L) or t10c12 (0-4 micromol/L). Addition of CLA or t10c12 to culture medium resulted in a dose-dependent increase in the numbers of apoptotic cells. The results of western blot analysis of total cell lysates showed that CLA and t10c12 increased the levels of cleaved caspase-9, caspase-3, and poly(ADP-ribose) polymerase but did not alter the levels of Bcl-2 family member proteins. However, these fatty acids were shown to increase the translocation of Bad and Bax to the mitochondria, increase mitochondrial membrane permeability, and induce the release of cytochrome c and Smac/Diablo from the mitochondria. In addition, CLA and t10c12 diminished Akt content and Akt phosphorylation. These findings indicate that physiological levels of t10c12 induce apoptosis in HT-29 colon cancer cells, which is mediated via mitochondrion-mediated events associated with a decline in Akt activity, an increase in the translocation of the pro-apototic Bad and Bax to the mitochondria, and the subsequent disruption of normal mitochondrial membrane potential.

  18. N2O reduction over a fullerene-like boron nitride nanocage: A DFT study

    NASA Astrophysics Data System (ADS)

    Esrafili, Mehdi D.

    2017-07-01

    We study, for the first time, the adsorption and catalytic decomposition of N2O molecule over a fullerene-like boron nitride nanocage (B12N12) using density functional theory calculations. It is found that the electron donating property of the cage plays an important role in the adsorption and activation of N2O. By the incorporation of a carbon atom into B12N12 cluster, our results indicate that the adsorption of N2O over B11N12C or B12N11C is more stronger than over pristine B12N12. The decomposition of N2O into N2 and O species over the C-doped clusters is energetically more favorable than that on B12N12. Moreover, the C-doping plays an important role in reducing the activation barrier for the CO + O* reaction over B12N12 surface.

  19. A Decade of Invasive Meningococcal Disease Surveillance in Poland

    PubMed Central

    Skoczyńska, Anna; Waśko, Izabela; Kuch, Alicja; Kadłubowski, Marcin; Gołębiewska, Agnieszka; Foryś, Małgorzata; Markowska, Marlena; Ronkiewicz, Patrycja; Wasiak, Katarzyna; Kozińska, Aleksandra; Matynia, Bożena; Hryniewicz, Waleria

    2013-01-01

    Background Neisseria meningitidis is a leading etiologic agent of severe invasive disease. The objective of the study was to characterise invasive meningococcal disease (IMD) epidemiology in Poland during the last decade, based on laboratory confirmed cases. Methods The study encompassed all invasive meningococci collected between 2002 and 2011 in the National Reference Centre for Bacterial Meningitis. The isolates were re-identified and characterised by susceptibility testing, MLST analysis, porA and fetA sequencing. A PCR technique was used for meningococcal identification directly from clinical materials. Results In the period studied, 1936 cases of IMD were confirmed, including 75.6% identified by culture. Seven IMD outbreaks, affecting mostly adolescents, were reported; all were caused by serogroup C meningococci of ST-11. The highest incidence was observed among children under one year of age (15.71/100,000 in 2011). The general case fatality rate in the years 2010–2011 was 10.0%. Meningococci of serogroup B, C, Y and W-135 were responsible for 48.8%, 36.6%, 1.2% and 1.2% of cases, respectively. All isolates were susceptible to third generation cephalosporins, chloramphenicol, ciprofloxacin, and 84.2% were susceptible to penicillin. MLST analysis (2009–2011) revealed that among serogroup B isolates the most represented were clonal complexes (CC) ST-32CC, ST-18CC, ST-41/44CC, ST-213CC and ST-269CC, and among serogroup C: ST-103CC, ST-41/44CC and ST-11CC. Conclusions The detection of IMD in Poland has changed over time, but observed increase in the incidence of the disease was mostly attributed to changes in the surveillance system including an expanded case definition and inclusion of data from non-culture diagnostics. PMID:23977184

  20. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 11 (International Computer Corp - Kloze N S Inc).

    DTIC Science & Technology

    1985-01-01

    N 0 mC. m.( m( m0 C) (0 (0 (0 0 Nf.0 r. cNNr4NO (0 en (0 MSP (0 *50 -W (0 -1 0 0 0 0 NC) 000 0 "-4 0 I(( (0 (1 1) P7 L) (0 in 4. -.4-4 m -& (D U (0... acCA -4N NN CcC4c xC4 NN N4 10L 0 ( Z-4 -I 4N . ".. (0 N 1-.U -4 .4 co -lOI m a) a) mne M 0. N r. I0 I0 I 0- 0. nc c n CI C% 004 0 00 0 04 " "N . .0

  1. Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place. Part 3 (E&E Reisen - Hiawatha Rubber Co)

    DTIC Science & Technology

    1990-01-01

    w ui 3j W3A b a w ww w w u i U j L A u a w Wa 4*to a o a N C4 anL (a "Cc cm em an a aD a A a GOO F6 46 404 S. >0 I.J man com 04 R 12 CM e4cc ~ m I...I WC: I co r aCCa 001 I-I 0. 0 NCJ o #1.U0 1-- 44 4 -4W C )C (JN -4~y 001 4 4 1I~ C’I1- mmcoco 44 I I. 4 C . a I- U. >- -4.- 010 00 - 1 . Za -C 4 vm...6W1-6z x. z-z- U~.L 4c -C I.--.4- z~L L W~mm 09~ ac -4- U..CI -I io ACLZ 0 U 3 0 0 (0 62 0 z I. zzz (A 6 000 Csd 314" 6 6 CA (ft 4.WU U . U A F4 F6 I I

  2. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 12. (Amherst, New Hampshire-White Sands Missile Range, New Mexico).

    DTIC Science & Technology

    1988-01-01

    0t NO (00 (000 00 0 0-40 (0-4 w f ɘ M 1 004 (0.4(0( (D -4C𔃾 ()0 riO (ON 00 0000 000൰ ()0 1400 m NIb . N t4.La- 0<-4 (04< 41’-. 0-4 -1 044 t *x 44(M...4C10000 "-( M A M I000.-I DE : 000 Lu Z - >--I -44- -4 -0 00 - 0-oc o 0 1-00 0-100o- I0 0-Cor) 00 04< 0<<<<<<<<<<<<::<:C:4C 0 000 4:0 4:00 < lCflO- I 0...i OLA - -00 0000 >-00 (00 I1M0-4 1 W(D ct00 (D0 C- 000 ( 0 DE D(C)t(D W (D( 0000 - 00 00 WAJ00 w 00 I 00-4 IWC1 - w 00 4 0 1--C-- - r-C- r- "-I- 300

  3. Evaluation of pectinolytic activities for oenological uses from psychrotrophic yeasts.

    PubMed

    Sahay, S; Hamid, B; Singh, P; Ranjan, K; Chauhan, D; Rana, R S; Chaurse, V K

    2013-08-01

    Of the twenty-three morphotypes of yeasts isolated from soil capable of utilizing pectin as sole carbon source at 6°C, two yeast isolates, one psychrotolerant (PT1) and one psychrophilic (SPY11), were selected according to their ability to secrete pectinolytic enzymes under some oenological conditions (temperature 6 and 12°C and pH 3.5) and ability or inability to grow above 20°C, respectively. As compared to their optimal activity, the three pectinolytic enzymes viz., pectin methyl esterase (PME), endopolygalacturonase (endo-PG) and exopolygalacturonase (exo-PG) isolated and assayed at pH 3.5 from PT1 were found to retain 39, 60 and 60% activity at 12°C and 40, 79 and 74% activity at 28°C, respectively. Likewise, the enzymes PME and endo-PG at pH 3.5 from SPY11 displayed 46 and 86% activity at 12°C and 50 and 60% activity at 28°C, respectively. All these enzymes showed 20-90% of residual activity at pH 3.5 and 6°C. The yeast isolates PT1 and SPY11 were identified as Rhodotorula mucilaginosa and Cystofilobasidium capitatum, respectively, on the basis of morphological, physiological and molecular characteristics. This study presents the first report on pectinolytic activities under major oenological conditions from psychrotolerant isolate R. mucilaginosa PT1 and psychrophilic isolate C. capitatum SPY11. The cold-active pectinolytic enzymes (PME, endo-PG and exo-PG) from the newly isolated and identified psychrophilic yeast Cystofilobasidium capitatum SPY11 and psychrotolerant yeast Rhodotorula mucilaginosa PT1that exhibited 50-80% of their optimum activity under some major oenological conditions pH (3.5) and temperatures (6 and 12°C) could be applied to wine production and juice clarification at low temperature. The psychrotrophic yeasts themselves could be applied to cold process for the production of enzymes thus saving cost of energy and protecting process from contamination. © 2013 The Society for Applied Microbiology.

  4. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    PubMed

    Rebbeck, Timothy R; Mitra, Nandita; Wan, Fei; Sinilnikova, Olga M; Healey, Sue; McGuffog, Lesley; Mazoyer, Sylvie; Chenevix-Trench, Georgia; Easton, Douglas F; Antoniou, Antonis C; Nathanson, Katherine L; Laitman, Yael; Kushnir, Anya; Paluch-Shimon, Shani; Berger, Raanan; Zidan, Jamal; Friedman, Eitan; Ehrencrona, Hans; Stenmark-Askmalm, Marie; Einbeigi, Zakaria; Loman, Niklas; Harbst, Katja; Rantala, Johanna; Melin, Beatrice; Huo, Dezheng; Olopade, Olufunmilayo I; Seldon, Joyce; Ganz, Patricia A; Nussbaum, Robert L; Chan, Salina B; Odunsi, Kunle; Gayther, Simon A; Domchek, Susan M; Arun, Banu K; Lu, Karen H; Mitchell, Gillian; Karlan, Beth Y; Walsh, Christine; Lester, Jenny; Godwin, Andrew K; Pathak, Harsh; Ross, Eric; Daly, Mary B; Whittemore, Alice S; John, Esther M; Miron, Alexander; Terry, Mary Beth; Chung, Wendy K; Goldgar, David E; Buys, Saundra S; Janavicius, Ramunas; Tihomirova, Laima; Tung, Nadine; Dorfling, Cecilia M; van Rensburg, Elizabeth J; Steele, Linda; Neuhausen, Susan L; Ding, Yuan Chun; Ejlertsen, Bent; Gerdes, Anne-Marie; Hansen, Thomas v O; Ramón y Cajal, Teresa; Osorio, Ana; Benitez, Javier; Godino, Javier; Tejada, Maria-Isabel; Duran, Mercedes; Weitzel, Jeffrey N; Bobolis, Kristie A; Sand, Sharon R; Fontaine, Annette; Savarese, Antonella; Pasini, Barbara; Peissel, Bernard; Bonanni, Bernardo; Zaffaroni, Daniela; Vignolo-Lutati, Francesca; Scuvera, Giulietta; Giannini, Giuseppe; Bernard, Loris; Genuardi, Maurizio; Radice, Paolo; Dolcetti, Riccardo; Manoukian, Siranoush; Pensotti, Valeria; Gismondi, Viviana; Yannoukakos, Drakoulis; Fostira, Florentia; Garber, Judy; Torres, Diana; Rashid, Muhammad Usman; Hamann, Ute; Peock, Susan; Frost, Debra; Platte, Radka; Evans, D Gareth; Eeles, Rosalind; Davidson, Rosemarie; Eccles, Diana; Cole, Trevor; Cook, Jackie; Brewer, Carole; Hodgson, Shirley; Morrison, Patrick J; Walker, Lisa; Porteous, Mary E; Kennedy, M John; Izatt, Louise; Adlard, Julian; Donaldson, Alan; Ellis, Steve; Sharma, Priyanka; Schmutzler, Rita Katharina; Wappenschmidt, Barbara; Becker, Alexandra; Rhiem, Kerstin; Hahnen, Eric; Engel, Christoph; Meindl, Alfons; Engert, Stefanie; Ditsch, Nina; Arnold, Norbert; Plendl, Hans Jörg; Mundhenke, Christoph; Niederacher, Dieter; Fleisch, Markus; Sutter, Christian; Bartram, C R; Dikow, Nicola; Wang-Gohrke, Shan; Gadzicki, Dorothea; Steinemann, Doris; Kast, Karin; Beer, Marit; Varon-Mateeva, Raymonda; Gehrig, Andrea; Weber, Bernhard H; Stoppa-Lyonnet, Dominique; Sinilnikova, Olga M; Mazoyer, Sylvie; Houdayer, Claude; Belotti, Muriel; Gauthier-Villars, Marion; Damiola, Francesca; Boutry-Kryza, Nadia; Lasset, Christine; Sobol, Hagay; Peyrat, Jean-Philippe; Muller, Danièle; Fricker, Jean-Pierre; Collonge-Rame, Marie-Agnès; Mortemousque, Isabelle; Nogues, Catherine; Rouleau, Etienne; Isaacs, Claudine; De Paepe, Anne; Poppe, Bruce; Claes, Kathleen; De Leeneer, Kim; Piedmonte, Marion; Rodriguez, Gustavo; Wakely, Katie; Boggess, John; Blank, Stephanie V; Basil, Jack; Azodi, Masoud; Phillips, Kelly-Anne; Caldes, Trinidad; de la Hoya, Miguel; Romero, Atocha; Nevanlinna, Heli; Aittomäki, Kristiina; van der Hout, Annemarie H; Hogervorst, Frans B L; Verhoef, Senno; Collée, J Margriet; Seynaeve, Caroline; Oosterwijk, Jan C; Gille, Johannes J P; Wijnen, Juul T; Gómez Garcia, Encarna B; Kets, Carolien M; Ausems, Margreet G E M; Aalfs, Cora M; Devilee, Peter; Mensenkamp, Arjen R; Kwong, Ava; Olah, Edith; Papp, Janos; Diez, Orland; Lazaro, Conxi; Darder, Esther; Blanco, Ignacio; Salinas, Mónica; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sukiennicki, Grzegorz; Huzarski, Tomasz; Byrski, Tomasz; Cybulski, Cezary; Toloczko-Grabarek, Aleksandra; Złowocka-Perłowska, Elżbieta; Menkiszak, Janusz; Arason, Adalgeir; Barkardottir, Rosa B; Simard, Jacques; Laframboise, Rachel; Montagna, Marco; Agata, Simona; Alducci, Elisa; Peixoto, Ana; Teixeira, Manuel R; Spurdle, Amanda B; Lee, Min Hyuk; Park, Sue K; Kim, Sung-Won; Friebel, Tara M; Couch, Fergus J; Lindor, Noralane M; Pankratz, Vernon S; Guidugli, Lucia; Wang, Xianshu; Tischkowitz, Marc; Foretova, Lenka; Vijai, Joseph; Offit, Kenneth; Robson, Mark; Rau-Murthy, Rohini; Kauff, Noah; Fink-Retter, Anneliese; Singer, Christian F; Rappaport, Christine; Gschwantler-Kaulich, Daphne; Pfeiler, Georg; Tea, Muy-Kheng; Berger, Andreas; Greene, Mark H; Mai, Phuong L; Imyanitov, Evgeny N; Toland, Amanda Ewart; Senter, Leigha; Bojesen, Anders; Pedersen, Inge Sokilde; Skytte, Anne-Bine; Sunde, Lone; Thomassen, Mads; Moeller, Sanne Traasdahl; Kruse, Torben A; Jensen, Uffe Birk; Caligo, Maria Adelaide; Aretini, Paolo; Teo, Soo-Hwang; Selkirk, Christina G; Hulick, Peter J; Andrulis, Irene

    2015-04-07

    Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. To identify mutation-specific cancer risks for carriers of BRCA1/2. Observational study of women who were ascertained between 1937 and 2011 (median, 1999) and found to carry disease-associated BRCA1 or BRCA2 mutations. The international sample comprised 19,581 carriers of BRCA1 mutations and 11,900 carriers of BRCA2 mutations from 55 centers in 33 countries on 6 continents. We estimated hazard ratios for breast and ovarian cancer based on mutation type, function, and nucleotide position. We also estimated RHR, the ratio of breast vs ovarian cancer hazard ratios. A value of RHR greater than 1 indicated elevated breast cancer risk; a value of RHR less than 1 indicated elevated ovarian cancer risk. Mutations of BRCA1 or BRCA2. Breast and ovarian cancer risks. Among BRCA1 mutation carriers, 9052 women (46%) were diagnosed with breast cancer, 2317 (12%) with ovarian cancer, 1041 (5%) with breast and ovarian cancer, and 7171 (37%) without cancer. Among BRCA2 mutation carriers, 6180 women (52%) were diagnosed with breast cancer, 682 (6%) with ovarian cancer, 272 (2%) with breast and ovarian cancer, and 4766 (40%) without cancer. In BRCA1, we identified 3 breast cancer cluster regions (BCCRs) located at c.179 to c.505 (BCCR1; RHR = 1.46; 95% CI, 1.22-1.74; P = 2 × 10(-6)), c.4328 to c.4945 (BCCR2; RHR = 1.34; 95% CI, 1.01-1.78; P = .04), and c. 5261 to c.5563 (BCCR2', RHR = 1.38; 95% CI, 1.22-1.55; P = 6 × 10(-9)). We also identified an ovarian cancer cluster region (OCCR) from c.1380 to c.4062 (approximately exon 11) with RHR = 0.62 (95% CI, 0.56-0.70; P = 9 × 10(-17)). In BRCA2, we observed multiple BCCRs spanning c.1 to c.596 (BCCR1; RHR = 1.71; 95% CI, 1.06-2.78; P = .03), c.772 to c.1806 (BCCR1'; RHR = 1.63; 95% CI, 1.10-2.40; P = .01), and c.7394 to c.8904 (BCCR2; RHR = 2.31; 95% CI, 1.69-3.16; P = .00002). We also identified 3 OCCRs: the first (OCCR1) spanned c.3249 to c.5681 that was adjacent to c.5946delT (6174delT; RHR = 0.51; 95% CI, 0.44-0.60; P = 6 × 10(-17)). The second OCCR spanned c.6645 to c.7471 (OCCR2; RHR = 0.57; 95% CI, 0.41-0.80; P = .001). Mutations conferring nonsense-mediated decay were associated with differential breast or ovarian cancer risks and an earlier age of breast cancer diagnosis for both BRCA1 and BRCA2 mutation carriers. Breast and ovarian cancer risks varied by type and location of BRCA1/2 mutations. With appropriate validation, these data may have implications for risk assessment and cancer prevention decision making for carriers of BRCA1 and BRCA2 mutations.

  5. Diagnostic Performance of 11C-choline PET/CT and FDG PET/CT in Prostate Cancer.

    PubMed

    Kitajima, Kazuhiro; Yamamoto, Shingo; Odawara, Soichi; Kobayashi, Kaoru; Fujiwara, Masayuki; Kamikonya, Norihiko; Fukushima, Kazuhito; Nakanishi, Yukako; Hashimoto, Takahiko; Yamada, Yusuke; Suzuki, Toru; Kanematsu, Akihiro; Nojima, Michio; Yamakado, Koichiro

    2018-06-01

    We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55.0%), 9 (45.0%), and 13 (65.0%), respectively. The patient-based sensitivity/specificity/accuracy/area under the receiver-operating-characteristic curve (AUC) values for 11C-choline-PET/CT for diagnosing local lesions were 90.9% /100%/ 95.0% / 1.0, whereas those for FDG-PET/CT were 45.5% /100%/ 75.0% / 0.773. Those for 11C-choline-PET/CT for node metastasis were 88.9% /100%/ 95.0% / 0.944, and those for FDG-PET/CT were 44.4%/100%/75.0%/0.722. Those for 11C-choline-PET/CT for bone metastasis were 84.6%/100%/90.0%/0.951, and those for FDG-PET/CT were 76.9% /100%/ 85.0% / 0.962. The AUCs for local lesion and node metastasis differed significantly (p=0.0039, p=0.011, respectively). The lesion-based detection rates of 11C-choline compared to FDG PET/CT for local lesion, and node and bone metastases were 91.7% vs. 41.7%, 92.0% vs. 32.0%, and 94.8% vs. 83.0% (p=0.041, p=0.0030, p<0.0001), respectively. 11C-choline-PET/CT is more useful for the staging and restaging of prostate cancer than FDG-PET/CT in Japanese men.

  6. Ambient temperature and biomarkers of heart failure: a repeated measures analysis.

    PubMed

    Wilker, Elissa H; Yeh, Gloria; Wellenius, Gregory A; Davis, Roger B; Phillips, Russell S; Mittleman, Murray A

    2012-08-01

    Extreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms. We hypothesized that outdoor temperature in the Boston, Massachusetts, area (1- to 4-day moving averages) would be associated with higher levels of biomarkers of inflammation and myocyte injury in a repeated-measures study of individuals with stable heart failure. We analyzed data from a completed clinical trial that randomized 100 patients to 12 weeks of tai chi classes or to time-matched education control. B-type natriuretic peptide (BNP), C-reactive protein (CRP), and tumor necrosis factor (TNF) were measured at baseline, 6 weeks, and 12 weeks. Endothelin-1 was measured at baseline and 12 weeks. We used fixed effects models to evaluate associations with measures of temperature that were adjusted for time-varying covariates. Higher apparent temperature was associated with higher levels of BNP beginning with 2-day moving averages and reached statistical significance for 3- and 4-day moving averages. CRP results followed a similar pattern but were delayed by 1 day. A 5°C change in 3- and 4-day moving averages of apparent temperature was associated with 11.3% [95% confidence interval (CI): 1.1, 22.5; p = 0.03) and 11.4% (95% CI: 1.2, 22.5; p = 0.03) higher BNP. A 5°C change in the 4-day moving average of apparent temperature was associated with 21.6% (95% CI: 2.5, 44.2; p = 0.03) higher CRP. No clear associations with TNF or endothelin-1 were observed. Among patients undergoing treatment for heart failure, we observed positive associations between temperature and both BNP and CRP-predictors of heart failure prognosis and severity.

  7. 44 CFR 12.9 - Closed meetings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Closed meetings. 12.9 Section... SECURITY GENERAL ADVISORY COMMITTEES § 12.9 Closed meetings. (a) The requirements of § 12.8 (c) and (d) of this part that meetings shall be open to the public and that the public shall be afforded an...

  8. 17 CFR 240.3a12-11 - Exemption from sections 8(a), 14(a), 14(b), and 14(c) for debt securities listed on a national...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...), 14(a), 14(b), and 14(c) for debt securities listed on a national securities exchange. 240.3a12-11... 14(c) for debt securities listed on a national securities exchange. (a) Debt securities that are listed for trading on a national securities exchange shall be exempt from the restrictions on borrowing...

  9. 40 CFR 52.2020 - Identification of plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Compliance and test methods 11/1/97 6/8/98, 63 FR 31116 (c)(131). Subchapter D—Motor Vehicle Emissions... 70893 (c)(229). Section 130.107 Variances 10/5/02 12/8/04, 69 FR 70893 (c)(229). Section 130.108 Test... 70895 (c)(230). Section 130.414 Modification of variance 10/11/08 10/18/10, 75 FR 63717. TEST METHODS...

  10. Probes for narcotic receptor mediated phenomena. 42. Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans

    PubMed Central

    Kim, Jin-Hee; Deschamps, Jeffrey R.; Rothman, Richard B.; Dersch, Christina M.; Folk, John E.; Cheng, Kejun; Jacobson, Arthur E.; Rice, Kenner C.

    2011-01-01

    A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of these compounds were determined. The N-phenethyl substituted ortho-c oxide-bridged phenylmorphan (rac-(3R,6aS,11aS)-2-phenethyl-2,3,4,5,6,11a-hexahydro-1H-3,6a-methanobenzofuro[2,3-c]azocin-10-ol (12)) was found to have the highest μ-opioid receptor affinity (Ki = 1.1 nM) of all of the a- through f-oxide-bridged phenylmorphans. Functional data ([35S]GTP-γ-S) showed that the racemate 12 was more than three times more potent than naloxone as an μ-opioid antagonist. PMID:21570305

  11. Crystal structure of triaquamaleatostrontium(II) monohydrate, [Sr(C{sub 4}H{sub 2}O{sub 4})(OH{sub 2}{sub 3}) {center_dot}] H{sub 2}O

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Diaz de Delgado, G.; Parra, P.P.; Briceno, A.

    1995-05-01

    (Sr(C{sub 4}H{sub 2}O{sub 4})(OH{sub 2}{sub 3}) {center_dot} H{sub 2}O is monoclinic, P2{sub 1}/n, with a = 11.476(2), b = 7.027(1), c = 12.344(2) {angstrom}, {beta} = 115.74(3){degrees}, V= 896.67 {angstrom}{sup 3}, Z = 4. The Sr atom is surrounded by nine oxygen atoms which come from four different maleate anions and three water molecules. The Sr-O distances range from 2.546(2) to 2.808(2) {angstrom}. The C-O distances are equal within the standard deviation 1.263(3) to 1.258(3) {angstrom}). In the maleate anion, the planes that contain the carboxylate groups form an angle of 74.44(9){degrees}. Both carboxylate groups deviate significantly from planarity. Themore » different coordination modes of the carboxylate group and the extensive hydrogen bonding present are responsible for the polymeric nature of the structure.« less

  12. COSAGE (Concepts Analysis Agency’s Combat Sample Generator) Analysis and Design Report. Volume 1.

    DTIC Science & Technology

    1984-04-29

    CM. C4UT.TI ON 12 5..j FUNCTION m2-. WLr 12 j -1 ---VUTINE w-fA.NEPT 112 5 3 ; CUTINE CA S. =V3L 1 1 5- P JU T loE z- 4 L 0Y.L C T FR S 11 55 P;ICESS... CUTINE PLAT.COUNT 5 -7 1 1 OUT I N PROX.CHiEOK 5 * 14ROUTINE Sw IT CH FrO 5 Figu, .- Modules Ranked by Functional IF Tests Conti nued 3-30 -SCIENCE...2 ; CUTIN -" ...CR T=CT 231 ;OUTI- = Kv .Ir UT T 232 UuTIN.-- Mi 3s.I~d3UT , 2 3 Z Ru T iiM d:’ 3 N-l 2". OUT:N .44 1’ ,1 L3i R OUT INE %4 l Nk 0 (3o

  13. The 12C(n, 2n)11C cross section from threshold to 26.5 MeV

    PubMed Central

    Eckert, T.; Hartshaw, G.; Padalino, S. J.; Polsin, D. N.; Russ, M.; Simone, A. T.; Brune, C. R.; Massey, T. N.; Parker, C. E.; Fitzgerald, R.; Sangster, T. C.; Regan, S. P.

    2018-01-01

    The 12C(n, 2n)11C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3H(d,n)4He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β+ decay of 11C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1H(n,p) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band. PMID:29732443

  14. The 12C(n, 2n)11C cross section from threshold to 26.5 MeV.

    PubMed

    Yuly, M; Eckert, T; Hartshaw, G; Padalino, S J; Polsin, D N; Russ, M; Simone, A T; Brune, C R; Massey, T N; Parker, C E; Fitzgerald, R; Sangster, T C; Regan, S P

    2018-02-01

    The 12 C(n, 2n) 11 C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3 H(d,n) 4 He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β + decay of 11 C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1 H(n,p) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band.

  15. 12C(n , 2 n )11C cross section from threshold to 26.5 MeV

    NASA Astrophysics Data System (ADS)

    Yuly, M.; Eckert, T.; Hartshaw, G.; Padalino, S. J.; Polsin, D. N.; Russ, M.; Simone, A. T.; Brune, C. R.; Massey, T. N.; Parker, C. E.; Fitzgerald, R.; Sangster, T. C.; Regan, S. P.

    2018-02-01

    The 12C(n ,2 n )11C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3H(d ,n )4He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β+ decay of 11C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1H(n ,p ) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band.

  16. Detection of Local, Regional, and Distant Recurrence in Patients With PSA Relapse After External-Beam Radiotherapy Using {sup 11}C-Choline Positron Emission Tomography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Breeuwsma, Anthonius J., E-mail: a.j.breeuwsma@uro.umcg.n; Departments of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen; Pruim, Jan

    2010-05-01

    Purpose: An elevated serum prostate-specific antigen (PSA) level cannot distinguish between local-regional recurrences and the presence of distant metastases after treatment with curative intent for prostate cancer. With the advent of salvage treatment such as cryotherapy, it has become important to localize the site of recurrence (local or distant). In this study, the potential of {sup 11}C-choline positron emission tomography (PET) to identify site of recurrence was investigated in patients with rising PSA after external-beam radiotherapy (EBRT). Methods and Materials: Seventy patients with histologically proven prostate cancer treated with EBRT and showing biochemical recurrence as defined by American Society formore » Therapeutic Radiology and Oncology consensus statement and 10 patients without recurrence underwent a PET scan using 400 MBq {sup 11}C-choline intravenously. Biopsy-proven histology from the site of suspicion, findings with other imaging modalities, clinical follow-up and/or response to adjuvant therapy were used as comparative references. Results: None of the 10 patients without biochemical recurrence had a positive PET scan. Fifty-seven of 70 patients with biochemical recurrence (median PSA 9.1 ng/mL; mean PSA 12.3 ng/mL) showed an abnormal uptake pattern (sensitivity 81%). The site of recurrence was only local in 41 of 57 patients (mean PSA 11.1 ng/mL at scan), locoregionally and/or distant in 16 of 57 patients (mean PSA 17.7 ng/mL). Overall the positive predictive value and negative predictive value for {sup 11}C-choline PET scan were 1.0 and 0.44 respectively. Accuracy was 84%. Conclusions: {sup 11}C-choline PET scan is a sensitive technique to identify the site of recurrence in patients with PSA relapse after EBRT for prostate cancer.« less

  17. 76 FR 2363 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ... Time on Tuesday, January 4, 2011. Docket Numbers: ER11-2365-000. Applicants: Paradise Solar Urban Renewal, L.L.C. Description: Paradise Solar Urban Renewal, L.L.C. submits tariff filing per 35.12: Paradise Solar Urban Renewal, L.L.C. to be effective 12/15/2010. Filed Date: 12/14/2010. Accession Number...

  18. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Branscome Julius Inc - Chriscott Supply)

    DTIC Science & Technology

    1993-01-01

    821702I0(04o ItIT 4444 9 0 cCNi "NIN 04 (0J a𔃻 47f-f a 1 >,Of enC o<i 020z0 o 0000 N 0)100 43 1)(1C) ’(1)V ý-lIA N! (’l( 0) -4 M LA 0. (-10 4-I I -4 -4...I I enC > N41a r0))00) 4 o mm q 7 40)0 ID)0)(0r-NO4 m0) 0 04( o r- N I m 0"-4-4(1)0) 0(1 4)100 II CDC>00 00 00 00 000t00 0I0to- -4--4-41000 10 11 D0>1...0004 11--4 WO"CN, .- 4 -4 -4.-4 -4IUU 0n C) A-r- M M c ( n00 nU,0) In.-4 W4 it0 1I (00 4 it 0 m ENc --IO <>" ൈ ý 0 0’-441 -4 m F" -4 t NN04C’JO< 1ý- Ul

  19. Virulence factors of Candida species isolated from patients with urinary tract infection and obstructive uropathy

    PubMed Central

    Alenzi, Faris Q.B.

    2016-01-01

    Objective: Fungal urinary tract infections due to Candida have increased significantly in recent years. Our research objective was to study Candida species in urine samples of patients with urinary tract infections (UTIs) associated with obstructive uropathy and to investigate the virulence factors of the isolated Candida. Methods: Patients were divided into two groups: Group I (cases): 50 patients with UTIs and obstructive uropathy. Group II (control): 50 patients with UTIs but with no functional or anatomical obstruction of their urinary tract. Clinical histories and physical examinations, together with laboratory investigations of urine samples were carried out in all patients in this study. Mid stream urine samples were examined microscopically and by fungal cell culture. The isolated Candida species were identified by analytical profile index (API). Candida Virulence factors were determined for the isolated Candida. The susceptibility to fluconazole was evaluated. Results: This study revealed an overall isolation rate of 27% of Candida species among all patient groups. The rate was 36% in cases, and 18% in controls, a difference found to be statistically significant (P<0.05). By API, C.albicans was detected in 44% of Candida species in cases, and in 33% in controls. While C.glabrata was detected in 28% of Candida species in cases, and in 22% in controls. C.tropicalis was detected in 17% of Candida species in cases, and in 22% in controls. Both C.krusei and C.kyfr were detected in 5.5% of Candida species in cases, and in 11% in controls. In terms of virulence factors the study showed that 11 out of 27 (40.5%) of Candida isolates were biofilm positive by tube adherence. Phospholipase activity was demonstrated in 12 out of 27 (44.5%) of Candida isolates. Secretory aspartic proteinase activity was demonstrated in 13 out of 27 (48%) of the Candida isolates. Conclusion: Candida is an important cause of UTIs and obstructive uropathy is a major predisposing factor. PMID:27022363

  20. EMI Array for Cued UXO Discrimination ESTCP MM-0601 Demonstration Data Report. APG Standardized UXO Test Site

    DTIC Science & Technology

    2010-01-14

    30 cm above the ground. The sensor boom is designed to pivot up to protect the sensors from damage due to impact with obstructions. This degree of...day for immediate use for background subtraction and future analysis regarding issues of background variability and the impact on fit parameter...I13 H13 G13 F13 E13 D13 C13 B13 A13 T12 S12 R12 Q12 P12 O12 N12 M12 L12 K12 J12 I12 H12 G12 F12 E12 D12 C12 B12 A12 T11 S11 R11 Q11 P11 O11 N11 M11

  1. Subcutaneous fatty acid composition of steers finished as weanlings or yearlings with and without growth promotants

    PubMed Central

    2013-01-01

    Background The current study evaluated the subcutaneous fatty acid (FA) composition of calf- and yearling-fed steers with or without growth promoting implants. Crossbred steers (n = 112; 267 ± 5.0 kg) of the same contemporary group were allocated to one of four production system and implant strategy based treatments in a completely randomized design with a 2 × 2 factorial arrangement of treatments. Results There were no interactions (P > 0.05) between production systems and growth promoting implants for the total and individual subcutaneous FA. Yearling as opposed to calf finishing reduced (P < 0.05) subcutaneous proportions of C20:3n-6, trans (t)12-18:1, C14:0, several minor cis-monounsaturated FA (c-MUFA; c9-14:1, c11-16:1, c11-18:1, c12-18:1, c13-18:1, c9-20:1 and c11-20:1), and increased (P < 0 .05) subcutaneous proportions of t11c15-18:2, total and individual branched-chain FA. Subcutaneous fat from steers implanted with growth promotants had higher (P < 0.05) proportions of total polyunsaturated FA (PUFA), total n-6 PUFA, C18:2n-6 and individual t-18:1 isomers (t6 to t10) compared to non-implanted steers. Conclusions Overall, current findings show that production systems and growth promotants led to only minor differences in subcutaneous FA composition of beef steers. PMID:24188642

  2. Prevalence of gastrointestinal bacterial pathogens in a population of zoo animals.

    PubMed

    Stirling, J; Griffith, M; Blair, I; Cormican, M; Dooley, J S G; Goldsmith, C E; Glover, S G; Loughrey, A; Lowery, C J; Matsuda, M; McClurg, R; McCorry, K; McDowell, D; McMahon, A; Cherie Millar, B; Nagano, Y; Rao, J R; Rooney, P J; Smyth, M; Snelling, W J; Xu, J; Moore, J E

    2008-04-01

    Faecal prevalence of gastrointestinal bacterial pathogens, including Campylobacter, Escherichia coli O157:H7, Salmonella, Shigella, Yersinia, as well as Arcobacter, were examined in 317 faecal specimens from 44 animal species in Belfast Zoological Gardens, during July-September 2006. Thermophilic campylobacters including Campylobacter jejuni, Campylobacter coli and Campylobacter lari, were the most frequently isolated pathogens, where members of this genus were isolated from 11 animal species (11 of 44; 25%). Yersinia spp. were isolated from seven animal species (seven of 44; 15.9%) and included, Yersinia enterocolitica (five of seven isolates; 71.4%) and one isolate each of Yersinia frederiksenii and Yersinia kristensenii. Only one isolate of Salmonella was obtained throughout the entire study, which was an isolate of Salmonella dublin (O 1,9,12: H g, p), originating from tiger faeces after enrichment. None of the animal species found in public contact areas of the zoo were positive for any gastrointestinal bacterial pathogens. Also, water from the lake in the centre of the grounds, was examined for the same bacterial pathogens and was found to contain C. jejuni. This study is the first report on the isolation of a number of important bacterial pathogens from a variety of novel host species, C. jejuni from the red kangaroo (Macropus rufus), C. lari from a maned wolf (Chrysocyon brachyurus), Y. kristensenii from a vicugna (Vicugna vicugna) and Y. enterocolitica from a maned wolf and red panda (Ailurus fulgens). In conclusion, this study demonstrated that the faeces of animals in public contact areas of the zoo were not positive for the bacterial gastrointestinal pathogens examined. This is reassuring for the public health of visitors, particularly children, who enjoy this educational and recreational resource.

  3. Hot bats: extreme thermal tolerance in a desert heat wave

    NASA Astrophysics Data System (ADS)

    Bondarenco, Artiom; Körtner, Gerhard; Geiser, Fritz

    2014-08-01

    Climate change is predicted to increase temperature extremes and thus thermal stress on organisms. Animals living in hot deserts are already exposed to high ambient temperatures ( T a) making them especially vulnerable to further warming. However, little is known about the effect of extreme heat events on small desert mammals, especially tree-roosting microbats that are not strongly protected from environmental temperature fluctuations. During a heat wave with record T as at Sturt National Park, we quantified the thermal physiology and behaviour of a single free-ranging little broad-nosed ( Scotorepens greyii, henceforth Scotorepens) and two inland freetail bats ( Mormopterus species 3, henceforth Mormopterus) using temperature telemetry over 3 days. On 11 and 13 January, maximum T a was ˜45.0 °C, and all monitored bats were thermoconforming. On 12 January 2013, when T a exceeded 48.0 °C, Scotorepens abandoned its poorly insulated roost during the daytime, whereas both Mormopterus remained in their better insulated roosts and were mostly thermoconforming. Maximum skin temperatures ( T skin) ranged from 44.0 to 44.3 °C in Scotorepens and from 40.0 to 45.8 °C in Mormopterus, and these are the highest T skin values reported for any free-ranging bat. Our study provides the first evidence of extensive heat tolerance in free-ranging desert microbats. It shows that these bats can tolerate the most extreme T skin range known for mammals (3.3 to 45.8 °C) and delay regulation of T skin by thermoconforming over a wide temperature range and thus decrease the risks of dehydration and consequently death.

  4. Optimum Aeroelastic Characteristics for Composite Supermaneuverable Aircraft.

    DTIC Science & Technology

    1986-07-31

    1󈨌D22 1 k 16 ’ cD 22YI Y6 WL k 17 ’ cD 22 Y, Y7 k 18 ’ -2cD 26YI1 Y6 gi 0 k19 : -2cD26Y I y 7 k1,10 12 2c Bo 10 1 󈧐D22 1 10 22 cD22 (y2 )2 k23 -2cD...2 6y1Y2 k24 -2cD 2 6 Y2Y 2 3 ,, 11 10 k -S-D + 2cD a 25 12 D22 5 2 12 5 2 k26 cD22 Y2 Y6 k27 cD22 y2 Y7 28 -2cD 2 6 Y2 Y6 k29 -2cD 26Y2 Y7 k’ "" 0y

  5. Effects of prolonged exercise versus multiple short exercise sessions on risk for metabolic syndrome and the atherogenic index in middle-aged obese women: a randomised controlled trial.

    PubMed

    Chung, JinWook; Kim, KwangJun; Hong, Jeeyoung; Kong, Hyoun-Joong

    2017-08-22

    Many people, although they may recognise the positive effects of exercise, do not exercise regularly owing to lack of time. This study aimed to investigate the effects of prolonged single-session exercise and multiple short sessions of exercise on the risk of metabolic syndrome and the atherogenic index in middle-aged obese women. Thirty-six participants were divided into the single-session group, multiple-session group, and control group. The single-session group engaged in one session of treadmill exercise for 30 min a day; the multiple-session group had three sessions of 10 min a day. Both groups exercised 3 days/week for 12 weeks. The control group did not perform any exercise. The single-session group showed decreases in weight (0.97 kg [95% C.I. = 0.09-1.83], p < .05), body mass index (0.43 kg/m 2 [95% C.I. = 0.03-0.81], p < .05), and fat mass (1.65 kg, [95% C.I. = 0.78-2.51], p < .01). Systolic blood pressure dropped in the single-session group (6.66 mmHg, [95% C.I. = 1.44-11.88], p < .05), and diastolic blood pressure dropped in the multiple-session group (3.38 mmHg, [95% C.I. = 1.44-5.88], p < .01). High-density lipoprotein cholesterol rose in the single-session group (4.08 mg/dL, [95% C.I. = -8.08-(-)0.07], p < .05) and dropped in the control group (10.75 mg/dL [95% C.I. = 1.95-19.54], p < .01). According to post hoc analysis, high-density lipoprotein cholesterol increased more in the single-session group than the control group (95% C.I. = 0.61-21.88, p < .05). Glucose levels decreased in both the single-session group (16 mg/dL [95% C.I. = 5.64-26.35], p < .01) and the multiple-session group (12.16 mg/dL, [95% C.I. = 2.18-22.14], p < .05). Waist circumference decreased in the single-session group (2.65 cm [95% C.I. = 1.46-3.83], p < .001) and multiple-session group (2.04 cm, [95% C.I. = 1.51-2.73], p < .001). Low-density lipoprotein cholesterol levels rose in both the multiple-session group (-15.79 mg/dL [95% C.I. = -34.24-(-)3.78], p < .05) and the control group (-22.94 mg/dL [95% C.I. = -44.63-(-)1.24], p < .05). The atherogenic index increased in the control group (-1.06 [95% C.I. = -1.69-(-)0.41], p < .01). The findings indicate that prolonged exercise is superior to multiple short sessions for improving the risk of metabolic syndrome and the atherogenic index in middle-aged obese women. However, multiple short sessions can be recommended as an alternative to prolonged exercise when the goal is to decrease blood glucose or waist circumference.

  6. Charge topology of the coherent dissociation of relativistic 11C and 12N nuclei

    NASA Astrophysics Data System (ADS)

    Artemenkov, D. A.; Bradnova, V.; Zaitsev, A. A.; Zarubin, P. I.; Zarubina, I. G.; Kattabekov, R. R.; Kornegrutsa, N. K.; Mamatkulov, K. Z.; Rukoyatkin, P. A.; Rusakova, V. V.; Stanoeva, R.

    2015-09-01

    The charge topology of coherent-dissociation events is presented for 11С and 12N nuclei of energy 1.2 GeV per nucleon bombarding nuclear track emulsions. This topology is compared with respective data for 7Be, 8,10B, 9,10C, and 14N nuclei.

  7. A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kodaka, Manami; Yang, Zeyu; Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang

    The development of the efficient screening system of detecting compounds that promote myogenesis and prevent muscle atrophy is important. Mouse C2C12 cells are widely used to evaluate myogenesis but the procedures of the assay are not simple and the quantification is not easy. We established C2C12 cells expressing the N-terminal green fluorescence protein (GFP) and the C-terminal GFP (GFP1–10 and GFP11 cells). GFP1–10 and GFP11 cells do not exhibit GFP signals until they are fused. The signal intensity correlates with the expression of myogenic markers and myofusion. Myogenesis-promoting reagents, such as insulin-like growth factor-1 (IGF1) and β-guanidinopropionic acid (GPA), enhancemore » the signals, whereas the poly-caspase inhibitor, z-VAD-FMK, suppresses it. GFP signals are observed when myotubes formed by GFP1–10 cells are fused with single nuclear GFP11 cells, and enhanced by IGF1, GPA, and IBS008738, a recently-reported myogenesis-promoting reagent. Fusion between myotubes formed by GFP1–10 and GFP11 cells is associated with the appearance of GFP signals. IGF1 and GPA augment these signals, whereas NSC23766, Rac inhibitor, decreases them. The conditioned medium of cancer cells suppresses GFP signals during myogenesis and reduces the width of GFP-positive myotubes after differentiation. Thus the novel split GFP-based assay will provide the useful method for the study of myogenesis, myofusion, and atrophy. - Highlights: • C2C12 cells expressing split GFP proteins show GFP signals when mix-cultured. • The GFP signals correlate with myogenesis and myofusion. • The GFP signals attenuate under the condition that muscle atrophy is induced.« less

  8. Atomic and molecular analysis highlights the biophysics of unprotonated and protonated retinal in UV and scotopic vision.

    PubMed

    Kubli-Garfias, Carlos; Vázquez-Ramírez, Ricardo; Cabrera-Vivas, Blanca M; Gómez-Reyes, Baldomero; Ramírez, Juan Carlos

    2015-09-26

    During the photoreaction of rhodopsin, retinal isomerizes, rotating the C11[double bond, length as m-dash]C12 π-bond from cis to an all-trans configuration. Unprotonated (UR) or protonated (PR) retinal in the Schiff's base (SB) is related to UV and light vision. Because the UR and PR have important differences in their physicochemical reactivities, we compared the atomic and molecular properties of these molecules using DFT calculations. The C10-C11[double bond, length as m-dash]C12-C13 dihedral angle was rotated from 0° to 180° in 45° steps, giving five conformers, and the following were calculated from them: atomic orbital (AO) contributions to the HOMO and LUMO, atomic charges, bond length, bond order, HOMO, LUMO, hardness, electronegativity, polarizability, electrostatic potential, UV-vis spectra and dipole moment (DM). Similarly, the following were analyzed: the energy profile, hybridization, pyramidalization and the hydrogen-out-of-plane (HOOP) wagging from the H11-C11[double bond, length as m-dash]C12-H12 dihedral angle. In addition, retinal with a water H-bond (HR) in the SB was included for comparison. Interestingly, in the PR, C11 and C12 are totally the LUMO and the HOMO, respectively, and have a large electronegativity difference, which predicts an electron jump in these atoms during photoexcitation. At the same time, the PR showed a longer bond length and lower bond order, with a larger DM, lower HOMO-LUMO gap, lower hardness and higher electronegativity. In addition, the AOs of -45° and -90° conformers changed significantly, from pz to py, during the rotation concomitantly with marked hybridization, smooth pyramidalization and lower HOOP activity. Clearly, the atomic and molecular differences between the UR and PR are overwhelming, including the rotational energy profile and light absorption spectra, which indicates that light absorption of UR and PR is already determined by the retinal characteristics of the SB protonation. The HR-model compared with UR shows a lower energy barrier and a discreet bathochromic effect in the UV region.

  9. Department of the Navy Justification of Estimates FY 1991 Budget Estimates Submitted to Congress January 1990, Operation & Maintenance, Navy. Book 1. Budget Activity 1. Strategic Forces. Budget Activity 2. General Purpose Forces. Budget Activity 3. Intelligence & Communications. Budget Activity 4. Airlift and Sealift.

    DTIC Science & Technology

    1990-01-01

    W a jwý 0 c! l U) to 0 C: C3 tdl &-j 𔃺 10 0 r r -" .-4GJ -4 w 4-𔃼w w .- 4 W &a’’ 0 󈧰 0 >1V) ( td ’- ~u 0 4 b W -4 a)i 0 1l-4 a, .. n (I = 0 -4 ý...to0 d)r- $4. 0)0 r. cd .,-~~ 4 C:s o a) (n44E-𔃺C W 0. 44CLH td c~ - 0ý 0r a;i w-4’-4 0’r0.. 12O4’w.. X-.41m C0) en (d 3)b-%- u s~~ -40r n 0- 1 0 0...c- ~ Li * to wC~C 0’~ -4 L)CrO0-40 CLTý -4 14 CLU L> w)i VQ. V) Li)- td -III.- 0 U -4 W ed Q C U - H bOC E 0 w u -𔃾 r-4 w &J.- w 4 0-I kw -H = IV -4

  10. Effects of a homologous series of linear alcohol ethoxylate surfactants on fathead minnow early life stages.

    PubMed

    Lizotte, R E; Wong, D C; Dorn, P B; Rodgers, J H

    1999-11-01

    Effects of a homologous series of three primarily linear alcohol ethoxylate surfactants were studied in laboratory flow-through 28-day early-life-stage tests with fathead minnow (Pimephales promelas Rafinesque). Surfactants were a C(9-11), C(12-13), and C(14-15) with an average of 6, 6.5, and 7 ethylene oxide units per mole of alcohol, respectively. Average measured surfactant recoveries were 103%, 81%, and 79% of nominal concentrations for the C(9-11) EO 6, C(12-13) EO 6.5, and C(14-15) EO 7 studies, respectively. Embryo survival at 48 h was not adversely affected at any of the concentrations tested. Impaired hatching and deformed fry were observed only in the C(12-13) EO 6.5 study. The 28-day LC50 values were 4.87, 2.39, and 1.02 mg/L for the C(9-11) EO 6, C(12-13) EO 6.5, and C(14-15) EO 7 surfactants, respectively. The corresponding NOECs for survival were 1.01, 1.76, and 0.74 mg/L. Posthatch fry growth was more sensitive than survival for the C(12-13) EO 6.5 and C(14-15) EO 7 surfactants. Survival of posthatch fry decreased with increasing surfactant alkyl chain length. Twenty-eight-day laboratory data were compared to 96-h laboratory, 10-day laboratory and 30-day stream mesocosm data for fathead minnow previously determined for these surfactants. Survival endpoints from the different exposures were comparable and only varied within a factor of two. Similarity of results suggests that it is possible to effectively use 96-h, 10-day, or 28-day laboratory data to predict environmental effects concentrations of these surfactants for fish. http://link.springer-ny. com/link/service/journals/00244/bibs/37n4p536.html

  11. Validation of an enzyme-linked immunosorbent assay (ELISA) for the measurement of canine S100A12.

    PubMed

    Heilmann, Romy M; Cranford, Shannon M; Ambrus, Andy; Grützner, Niels; Schellenberg, Stefan; Ruaux, Craig G; Suchodolski, Jan S; Steiner, Jörg M

    2016-03-01

    Canine S100 calcium-binding protein A12 (cS100A12) shows promise as biomarker of inflammation in dogs. A previously developed cS100A12-radioimmunoassay (RIA) requires radioactive tracers and is not sensitive enough for fecal cS100A12 concentrations in 79% of tested healthy dogs. An ELISA assay may be more sensitive than RIA and does not require radioactive tracers. The purpose of the study was to establish a sandwich ELISA for serum and fecal cS100A12, and to establish reference intervals (RI) for normal healthy canine serum and feces. Polyclonal rabbit anti-cS100A12 antibodies were generated and tested by Western blotting and immunohistochemistry. A sandwich ELISA was developed and validated, including accuracy and precision, and agreement with cS100A12-RIA. The RI, stability, and biologic variation in fecal cS100A12, and the effect of corticosteroids on serum cS100A12 were evaluated. Lower detection limits were 5 μg/L (serum) and 1 ng/g (fecal), respectively. Intra- and inter-assay coefficients of variation were ≤ 4.4% and ≤ 10.9%, respectively. Observed-to-expected ratios for linearity and spiking recovery were 98.2 ± 9.8% (mean ± SD) and 93.0 ± 6.1%, respectively. There was a significant bias between the ELISA and the RIA. The RI was 49-320 μg/L for serum and 2-484 ng/g for fecal cS100A12. Fecal cS100A12 was stable for 7 days at 23, 4, -20, and -80°C; biologic variation was negligible but variation within one fecal sample was significant. Corticosteroid treatment had no clinically significant effect on serum cS100A12 concentrations. The cS100A12-ELISA is a precise and accurate assay for serum and fecal cS100A12 in dogs. © 2016 American Society for Veterinary Clinical Pathology.

  12. 78 FR 22539 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... LLC. E-12 ER12-1772-000 Southwest Power Pool, Inc. E-13 ER13-63-000 Lockhart Power Company. E-14 ER11... CP12-6-001, CP12-7-001 El Paso Natural Gas Company, L.L.C. C-2 CP12-468-001 Atlas Pipeline Mid-Continent WestTex, LLC Pioneer Natural Resources USA, Inc. C-3 CP10-449-001 Northern Natural Gas Company...

  13. Cyclosporine A area-under-time-concentration-curve in rheumatologic patients after the first dose. Which of the sparse sampling strategies will predict the best?

    PubMed

    Koristkova, B; Grundmann, M; Suchy, D; Perinova, I; Brozmanova, H; Mayer, O

    2011-05-01

    The aim of the present study was to validate the limited sampling strategies (LSS:s) for prediction of AUC of cyclosporine A (CsA) after the first dose in rheumatologic patients. 22 patients suffering from rheumathoid arthritis, systemic lupus erythematodus, ankylosing spondylitis dermato(poly)myositis or seronegative spondylarthritis were treated with Neoral® (female/male: 11/3, mean ± SD: age 49 ± 14 y, body weight 75 ± 12 kg, height 166 ± 7 cm, dose 71 ± 25 mg, dose per kg 1.0 ± 0.3 mg/kg), or Consupren® (7/1, 78 ± 36, 175 ± 8, 82 ± 22, 1.1 ± 0.3). Two patients whose C12h were missing were excluded from the AUC0-12 calculation. Whole blood levels of CsA were analyzed with HPLC. Blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, and 12 hours after taking the first dose. Altogether 115 LSS:s obtained from the literature were validated. A linear trapezoidal rule was used as a reference method. Mean percentage prediction error (%PE) < ± 15% and maximal one value of absolute %PE > 30% were considered to be acceptable. The root mean squared error (RMSE) was evaluated for equations that passed the criteria. The best performance with all values of the absolute %PE < 30% was found in three LSS:s for AUC0-12 and two for AUC0-8: AUC0-12 = 123.792 + 1.165 × C1h + 3.021 × C3h + 7.33 × C8h; 97.6 + 1.27 × C1h + 3.14 × C3h + 4.06 × C6h; or 124.3 + 1.34 × C1h - 0.16 × C2h + 3.27 × C3h + 3.96 × C6h; AUC0-8 = -19.8 + 1.99 × C2h + 2.38 × C4h + 3.15 × C6h or -22.4 + 2.51 × C2h + 5.49 × C6h. Validation criteria were further fulfilled in AUC0-12 = 24 + 3.66 × C0h + 2.11 × C1.5h + 4.54 × C4h or 0.2 + 2 × C2h + 10.2 × C6h; AUC0-8 = 55.37 + 2.89 × C0h + 1.08 × C1 + 0.9 × C2h + 2.23 × C3h; and AUC0-4 = -41 + 1.17 × C1h + 1.85 × C2h. Only one equation proposed for AUC0-6 did not pass the validation criteria. Equations validated for prediction of AUC0-12, AUC0-8 and AUC0-4 might be used for LSS:s of CsA independently of the length of treatment, indication, dosage or galenic formulation.

  14. Preparation of a 1:1 cocrystal of genistein with 4,4‧-bipyridine

    NASA Astrophysics Data System (ADS)

    Zhang, Yu-Nan; Yin, He-Mei; Zhang, Yu; Zhang, Da-Jun; Su, Xin; Kuang, Hai-Xue

    2017-01-01

    Based on analysing the relationship between the possible number of intermolecular O-H···N hydrogen bonds and the stoichiometric ratio, a 1:1 C15H10O5·C10H8N2 (genistein-4,4‧-bipyridine) cocrystal has been prepared by solution evaporation and characterized. This work successfully demonstrates that the stoichiometric ratio could be inferred by analysing the possible number of intermolecular hydrogen bonds between flavonoids and amines. The strategy provides a facile route for rational designing cocrystal of flavonoids with amines. Additionally, the title cocrystal shows advantages in terms of solubility and antibacterial properties in comparison to pure genistein.

  15. FY 1998/1999 Defense Budget Review Descriptive Summaries

    DTIC Science & Technology

    1996-09-01

    OA 4J0 0.Ia0 04406 (A 4J -H 0 93 .441 1V 0U 0 $4 v00$ ,,4 4J ý’~4 ’A0’ V) 4 10 rio o 410wa4 0) O .4v CL0 0ki % 0410 4 0S - -M 44 0 oC0 005o H~r...ý . 4 .𔃾 d C)cl a & a J 4 4r 4. ) 0 1 a.J10f ý4.C 14 a 1:6 Im pa4~) w-~ ’.4 0 0 ; - 4 td 0 NC)E CN N 0 12 . 0-4 Q40 $4 )1 ~ u 4 004 to 0 0 )4 4b...41 4)QC) fd)" 004O W . 41 $4 d 44 41o r. 4 1$ to -4 C3 02 4 JQ m t 4.44 MOO 0Cr. td 01 ’UHO 4.) 0 -r4 F a I o 1U 0 r 4.) 0%0) T)aC o In a f- 49 r4 41

  16. Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease.

    PubMed

    Le Huu, Doanh; Kimura, Hiroshi; Date, Mutsumi; Hamaguchi, Yasuhito; Hasegawa, Minoru; Hau, Khang Tran; Fujimoto, Manabu; Takehara, Kazuhiko; Matsushita, Takashi

    2014-06-01

    Murine sclerodermatous chronic graft-versus-host disease (Scl-cGVHD) is a model for human Scl-cGVHD and systemic sclerosis (SSc). Syk is expressed in most of hematopoietic cells, fibroblasts, and endothelial cells. Syk is a protein tyrosine kinase that has an important role in transmitting signals from a variety of cell surface receptors. This study aims to investigate the effect of R788 (fostamatinib sodium), an oral prodrug that is rapidly converted to a potent inhibitor of Syk, R406, on Scl-cGVHD. R788 was orally administered twice a day to allogeneic recipients from day 14 to day 42 after bone marrow transplantation (BMT). In vitro, proliferation of GVHD-derived CD4(+) T cells and CD11b(+) cells was analyzed by R406. Allogeneic BMT increased Syk phosphorylation in T, B, and CD11b(+) cells. The administration of R788 attenuated severity and fibrosis of Scl-cGVHD. The elevated expressions of CXCR4 on T cells, B cells, and CD11b(+) cells were significantly down-regulated by R788 treatment. R788 reduced memory CD4(+) T cells (CD44(hi)CD62L(-)CD4(+)). R406 inhibited proliferation of GVHD CD4(+) T cells and CD11b(+) cells in vitro. In addition, R788 treatment, inhibited proliferation of CD11b(+) cells in Scl-cGVHD mice. R788 treatment also reduced skin mRNA expressions of MCP-1, MIP-1α, IFN-γ, IL-13, IL-17A, and TGF-β1, but not influenced RANTES, CXCL12, and TFN-α. Blockade of Syk suppressed migration factor of immune cells and antigen-specific memory CD4(+) T cells and proliferation and activation of GVHD CD4(+) T cells and CD11b(+) cells. The current studies suggested that Syk inhibitor is a potential candidate for use in treating patients with Scl-cGVHD and SSc. Copyright © 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

  17. Synthesis and re-investigation of the elastic properties of single-crystal magnesium silicate perovskite

    NASA Astrophysics Data System (ADS)

    Yeganeh-Haeri, Amir

    1994-12-01

    Single crystals of MgSiO3 in the perovskite structure have been grown at a peak pressure of 26 GPa and temperature of approximately 1600 K using a 2000 ton uniaxial split-sphere high-pressure apparatus (USSA-2000). The specimens were subsequently utilized to re-investigate the single-crystal elastic properties of this phase at ambient conditions using laser Brillouin spectroscopy. The nine adiabatic single-crystal elastic stiffness coefficients, in units of GPa, are: C11 = 482, C22 = 537, C33 = 485, C44 = 204, C55 = 186, C66 = 147, C12 = 144, C13 = 147, C23 = 146. The resulting estimated Voigt-Reuss-Hill (VRH) aggregate isotropic elastic moduli are: K=264.0 and mu = 177.3 GPa, respectively. The single-crystal elastic moduli of MgSiO3 perovskite display a pattern that is elastically somewhat anisotropic. The maximum shear and compressional velocities are 18% and 7% greater than the minimum. The (010) crystallographic direction contains both the fastest and the slowest shear wave velocities. If, under lower mantle conditions, magnesium silicate perovskite grains were to become preferentially oriented, a shear wave propagating in the Earth's lower mantle could become polarized with two distinct velocities. The observed density and seismic parameter of the lower mantle over the depth range of 1000-2700 km are compared with the calculated profiles for a model mantle consisting of pure perovskite (Mg(0.89)Fe(0.11))SiO3 and for a mixture composed of silicate perovskite and magnesiowuestite using our new elasticity results. At present, literature values of thermoelastic properties for silicate perovskite, in particular, the coefficient of thermal expansion and the temperature derivative of the isothermal bulk modulus, vary widely. Because of this disparity, we find that mantle models ranging from pure perovskite to 'pyrolitic'-type compositions provide acceptable fits to the seismically observed density and velocity profiles of the Earth's lower mantle.

  18. Refractive effects and Airy structure in inelastic 16O+12C rainbow scattering

    NASA Astrophysics Data System (ADS)

    Ohkubo, S.; Hirabayashi, Y.; Ogloblin, A. A.; Gloukhov, Yu. A.; Dem'yanova, A. S.; Trzaska, W. H.

    2014-12-01

    Inelastic 16O+12C rainbow scattering to the 2+ (4.44 MeV) state of 12C was measured at the incident energies, EL = 170, 181, 200, 260, and 281 MeV. A systematic analysis of the experimental angular distributions was performed using the coupled-channels method with an extended double folding potential derived from realistic wave functions for 12C and 16O calculated with a microscopic α cluster model and a finite-range density-dependent nucleon-nucleon force. The coupled-channels analysis of the measured inelastic-scattering data shows consistently some Airy-like structure in the inelastic-scattering cross sections for the first 2+ state of 12C, which is somewhat obscured and still not clearly visible in the measured data. The Airy minimum was identified from the analysis and the systematic energy evolution of the Airy structure was studied. The Airy minimum in inelastic scattering is found to be shifted backward compared with that in elastic scattering.

  19. 76 FR 43370 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... 06-05-C-01-CLL, College Station, TX...... 06/01/11 $799,557 $755,492 04/01/09 04/01/09 06-05-C-03-MOB, Mobile, AL 06/02/11 4,835,101 4,850,267 02/01/12 06/01/15 07-02-C-01-ECP, Panama City, FL 06/02/11 41,968,640 41,968,640 04/01/39 04/01/39 92-01-C-06-STL, St. Louis, MO 06/02/11 58,088,964 84,607,850 08/01/95...

  20. [A model of world population growth as an experiment in systematic research].

    PubMed

    Kapitsa, S

    1997-01-01

    A mathematical model was developed for the estimation of global population growth, and the estimates were compared with those of the UN and covered the stretch of 4.4 million years B.C. to the years 2175 and 2500 A.D. The estimates were also broken down into human, geological, and technological historical periods. The model showed that human population would stabilize at the level of 14 billion around 2500 A.D. and 13 billion around 2200 A.D., in accordance with UN projections. It also revealed the history of human population growth through the following stages (UN figures are listed in parentheses): 100,000, about 1.6 million years ago; 5 (1-5) million, 35,000 B.C.; 21 (10-15) million, 7000 B.C.; 46 (47) million, 2000 B.C.; 93 (100-230) million, at the time of Christ; 185 (275-345) million, 1000 A.D.; 366 (450-540) million, 1500 A.D.; 887 (907) million, 1800 A.D.; 1158 (1170) million, 1850 A.D.; 1656 (1650-1710) million, 1900 A.D.; 2812 (2515) million, 1950 A.D.; 5253 (5328) million, 1990 A.D.; 6265 (6261) million, 2000 A.D.; 10,487 (10,019) million, 2050 A.D.; 12,034 (11,186) million, 2100 A.D.; 12,648 (11,543) million, 2150 A.D.; 12,946 (11,600) million, 2200 A.D.; and 13,536 million, 2500 A.D. The model advanced the investigation of phenomena by studying the interactions between economical, technological, social, cultural, and biological processes. The analysis showed that humanity has reached a critical phase in its growth and that development in each period depended on external, not internal, factors. This permits the formulation of the principle of demographic imperative (distinct from the Malthusian principle), which states that resources determine the speed and extent of the growth of population.

  1. [Pharmacokinetics and bioequivalence of atorvastatin calcium tablets in healthy male Chinese volunteers].

    PubMed

    Shen, Yi; Zhang, Yi-fan; Chen, Xiao-yan; Guo, Li-xia; Zhong, Da-fang

    2012-03-01

    To compare the bioequivalence and pharmacokinetics of national made and imported atorvastatin in healthy male Chinese volunteers after single oral administration. This randomized sequence, open-label, two-period crossover study with a one-week washout period between doses was performed in 24 fasting healthy Chinese males. They were randomly assigned to receive 20 mg of either the test (national made) or reference (imported) formulation orally. The blood samples were collected over a 72-hour period. Plasma concentrations of parent atorvastatin (AT), ortho-hydroxy-atorvastatin (o-OAT) and para-hydroxy-atorvastatin (p-OAT) were simultaneously determined using the validated liquid chromatography-tandem mass spectrometry method, the bioequivalence was also evaluated throughout the study. The main pharmacokinetic parameters of test and reference formulations were as follows: the values of C(max) for AT were (10.6 ± 11.9) µg/L and (10.6 ± 9.8) µg/L, t(1/2z) were (11.4 ± 3.9) h and (11.4 ± 5.3) h, AUC(0-t) were (54.2 ± 37.4) µg×h(-1)×L(-1) and (51.7 ± 34.1) µg×h(-1)×L(-1), respectively. The values of C(max) for o-OAT were (7.8 ± 4.5) µg/L and (7.6 ± 4.3) µg/L, t(1/2z) were (12.3 ± 4.2) h and (11.9 ± 3.4) h, AUC(0-t) were (96.8 ± 48.2) µg×h(-1)×L(-1) and (92.3 ± 44.4) µg×h(-1)×L(-1), respectively. The values of C(max) for p-OAT were (0.5 ± 0.4) µg/L and (0.4 ± 0.3) µg/L, t(1/2z) were (18.4 ± 12.4) h and (23.3 ± 17.8) h, AUC(0-t) were (15.9 ± 12.3) µg×h(-1)×L(-1) and (13.8 ± 8.11) µg×h(-1)×L(-1), respectively. The relative bioavailability of AT and o-OAT in test formulation were (105.3 ± 20.7)% and (107.8 ± 23.2)%, respectively. The 90% confidence interval of the test/reference geometric mean ratios of AUC(0-t) for AT and o-OAT were (97.7 - 110.5)% and (98.3 - 111.3)%, C(max) for AT and o-OAT were (75.8 - 114.0)% and (90.6 - 122.9)%, they were all located within the bioequivalence criteria range (80% - 125% for AUC, and 70% - 143% for C(max)). The result demonstrated that two formulations were bioequivalent.

  2. Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Part 6 (KYOWA DENGYO CORP-N D S INC)

    DTIC Science & Technology

    1990-01-01

    czt a.r 1= Lme mi.). L).) 6 A N...U3 aa a a 0 1a a 0 Ca a =0 a 0 a2 1.2 a a ama 4 a 9 aaAU91 z a a a u a UU a ; t Z a U 2 cc aF - 2 -1. : . R. Ra a, Z .4 a I,2 g il a9a a90 a - 12...N 04a 00s 0o 0000 0 ŘW0 -. CW40 41.0 0 W to c 0 (D~4 OW v s C~C.) rii CO.) U3U 9z Di C.) C. .4 cc .4.4 .4 . ZZE ~ E to 40 ) C’) NtD a) M af . )

  3. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Fort Hood Texas - Northfield Vermont)

    DTIC Science & Technology

    1993-01-01

    00N00LALAm00)LA0 -- n, o-, nc4-- n( )m-zTI o-ir -- * 0)CIO 1C) -- i-s a) CI W N 1wo jini nI-I 0 o o01 o ,w 4-1t in WL L L L 0 00 0 0 A 0 01"C4 0 ’ ~ 0C14r...411 N ,N 1`4 NJ I Q -4-4 to >-.-- zzzzzzz z zz ZZ ZZ> >>--> - Uf C41I 0-40 11 au Mə <<- JINI 4- (04 4N014INN Uf 00(n o U n (inl ý4 - I4-4- 4 -4 i...N Is 1(000o atoz z z z z z z z zz z motto00 It 7) 00 0U)..VN(to-4 N l (a0 000 0 0 In01C* an 0 Ga I(00 Gao If 0)C0an.0(0 In O0NC 0 0 0 -*MM’ N o A IC

  4. All Prime Contract Awards by State or Country, Place, and Contractor. Part 5 (Vineburg, California-Wyoming, Delaware)

    DTIC Science & Technology

    1990-01-01

    4 a:: wi :t mo 400 N erntiofl0o~Nco cf),4In m in N It N O0) I I C) q N! 1 )-11uIto00 N qt 1- 0 0 0) 15.1 C: c 40 N Me o- -4 CV) 00 I M100 00 Nf 04 NCV ...00.-4 1 61 4 t wt it 4 q**- 0 nCV ) ..I)0)00 I- M m0Y) m0I00m0MCV00m000Y00mIn00Y00000m000000000) IL.4 (-4 NNINNNNNNNNN 00 00000C004- q- .. 4-4- 4 - 44...4N N ൰CV N N 4 .40 8&.NC40000 NCV )(’ am 000 N> in 24 Z.C’%> a EI*0 woo E E E E E 9 III - I Coc 1140 -i at 0 0 -mN 06* 00 Is40 10 V V 1L a. UI *6

  5. Rate constants of nine C6-C9 alkanes with OH from 230 to 379 K: chemical tracers for [OH].

    PubMed

    Sprengnether, Michele M; Demerjian, Kenneth L; Dransfield, Timothy J; Clarke, James S; Anderson, James G; Donahue, Neil M

    2009-04-30

    We report absolute rate-constant measurements for the reactions of nine C(6)-C(9) alkanes with OH in 8-10 torr of nitrogen from 230 to 379 K in the Harvard University High-Pressure Flow System. Hydroxyl concentrations were measured using laser-induced fluorescence, and alkane concentrations were measured using Fourier transform infrared Spectroscopy. Ethane's reactivity was simultaneously measured as a test of experimental performance. Results were fit to a modified Arrhenius equation based on transition state theory (ignoring tunneling), k(T) = Be(-E(a)/T)/(T(1 - e(- 1.44nu(1)/T))(2)(1 - e(- 1.44nu(2)/T)), with nu(1) and nu(2) bending frequencies, set to 280 and 500 cm(-1). Results were as follows for B (10(-9) K cm(3) s(-1)), E(a) (K), and k(298) (10(-12) cm(3) s(-1)): cyclohexane, 3.24 +/- 0.14, 332 +/- 12, 7.13; cyclo-octane, 3.47 +/- 0.30, 149 +/- 26, 14.1; 2-methylhexane, 1.45 +/- 0.08, 110 +/- 15, 6.72; 3-methylhexane, 1.50 +/- 0.08, 128 +/- 16, 6.54; methylcyclopentane, 1.65 +/- 0.07, 109 +/- 13, 7.65; methylcyclohexane, 1.86 +/- 0.09, 83 +/- 14, 9.43; methylcycloheptane, 3.45 +/- 0.45, 142 +/- 36, 14.4; n-propylcyclohexane, 2.83 +/- 0.14, 112 +/- 15, 13.0; isopropylcyclohexane, 1.79 +/- 0.11, -44 +/- 34, 13.9. Uncertainties are one sigma results from linear regression fits and are likely underestimated. Room temperature rate coefficients of reaction are accurate to within 10% at two sigma. A comprehensive fit to 17 separate studies including the present work for cyclohexane gives good agreement with the present results: terms as above, 3.09 +/- 0.12, 326 +/- 12, 6.96. Five of these compounds are routinely measured in urban air within a suite of atmospheric nonmethane hydrocarbons and reach parts per billion levels. The remaining four are C8-C9 cycloalkanes with low anthropogenic emissions. Because of their high, specific reactivity with OH, their concentration decays may be used as an indirect measurement of [OH] in the atmosphere or laboratory. This data set serves to further constrain the reaction barriers for cyclohexane and cyclo-octane, is the first temperature-dependent study for methylcyclopentane and methylcyclohexane, and provides the first measurements for the rate constants of the remaining five hydrocarbons. Reactivity follows general trends observed for other saturated alkanes, increasing with size and extent of substitution. Reaction barriers are heavily influenced by the presence of tertiary hydrogens. The reaction barrier for cyclo-octane is significantly lower than that for cyclohexane, a result that is not predicted from our current understanding of hydrocarbon reactivity.

  6. All Prime Contract Awards by State or Country, Place and Contractor. Part 11. (Aitkin, Minnesota-Zephyr Cove, Nevada)

    DTIC Science & Technology

    1989-01-01

    0 )N 41 nuuu~f~01Xflininu33x33:33330I- ( 5 0 CL L . CL.CL 0ilto1 0 N 11000000000000000000000011 2 0 ) 0 ) 0 ) 0 ) 0 ) 011Z2 I00N 11 z00 000000 0000...4 4 4 4 4 4 44 IIC1 ( 0 -NOI 5 )(~ )) C)’C1: 00c ’ I 0 00 000M 00 0 0 0 00 0 0 0 0 I.I < 0 -~l 0 - 00 00 00 0000000000000000000L.I.. WU-I A 40-eN Ii~ mj X00...I m N 1(A) 04 ɜ a I-I -. Z .8 - --. 1-1 - 1--.1-.1-

  7. Fourier Transform Spectroscopy of 18O-Enriched Carbonyl Sulfide from 1825 to 2700 cm -1

    NASA Astrophysics Data System (ADS)

    Strugariu, T.; Naı̈m, S.; Fayt, A.; Bredohl, H.; Blavier, J.-F.; Dubois, I.

    1998-06-01

    We have measured the Fourier transform spectrum of carbonyl sulfide from 1825 to 2700 cm-1, using a sample enriched in both18O (94.0%) and17O (1.54%). A careful calibration yields a line-position accuracy between 1.5 and 3.0 10-5cm-1. We have observed and analyzed 118 infrared bands of which 93 are measured for the first time: 55 for18O12C32S, 20 for18O12C34S, 11 for18O12C33S, 1 for18O12C36S, 12 for17O12C32S, 4 for17O12C34S, 2 for17O12C33S, and 13 for18O13C32S. Intensities are also reported and analyzed for all those bands. The intensity accuracy is better than 10%, and the precision of approximately 1% allows us to determine some Herman-Wallis coefficients.

  8. Roseomonas aeriglobus sp. nov., isolated from an air-conditioning system.

    PubMed

    Lee, Yunho; Jeon, Che Ok

    2018-03-01

    A novel pale pink-coloured, strictly aerobic, Gram-stain negative bacterial strain, designated strain KER25-12 T , was isolated from a laboratory air-conditioning system in South Korea. Cells were observed to be non-motile cocci showing positive catalase and oxidase reactions. Strain KER25-12 T was found to grow at 10-30 °C (optimum, 25-30 °C), at pH 4.0-9.0 (optimum, pH 6.0-7.0) and in the presence of 0-2% (w/v) NaCl (optimum, 0%). Ubiquinone-10 and spermidine were detected as the sole respiratory quinone and the predominant polyamine, respectively. The major fatty acids were identified as summed feature 8 (comprising C 18:1 ω7c and/or C 18:1 ω6c), summed feature 3 (comprising C 16:1 ω7c and/or C 16:1 ω6c), C 16:0 and C 18:0 . The genomic DNA G+C content of strain KER25-12 T was determined to be 70.0 mol%. The major polar lipids were identified as diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine and an unidentified aminolipid. Phylogenetic analysis based on 16S rRNA gene sequence comparison revealed that strain KER25-12 T belongs to the genus Roseomonas and shows high sequence similarity to Roseomonas aerilata 5420S-30 T (98.57%), Roseomonas pecuniae N75 T (97.44%) and Roseomonas vinacea CPCC 100056 T (97.40%). Based on the morphological, physiological, chemotaxonomic and phylogenetic features, strain KER25-12 T is concluded to represent a novel species of the genus Roseomonas, for which the name Roseomonas aeriglobus sp. nov. is proposed. The type strain is KER25-12 T (= KACC 19282 T  = JCM 32049 T ).

  9. Effects of temperature on virogenesis of bluetongue virus serotype 11 in Culicoides variipennis sonorensis.

    PubMed

    Mullens, B A; Tabachnick, W J; Holbrook, F R; Thompson, L H

    1995-01-01

    Culicoides variipennis sonorensis females were fed bluetongue virus serotype 11 mixed in sheep blood and were held at constant temperatures of 32, 27, 21 and 15 degrees C. Virogenesis, as measured by enzyme-linked immunosorbent assay (ELISA), proceeded significantly faster at higher temperatures. Based on ELISA absorbance > or = 0.2, some flies first were categorized as infected after 1 day, 2 days and 4 days at 32, 27 and 21 degrees C, respectively. Peak levels of virus antigen were seen after 5-7, 7-13 and 18-22 days for flies held at 32, 27 and 21 degrees C, respectively. There was no significant virus replication in flies held at 15 degrees C for 22 days, but latent virus replicated and was detected easily (44% infection) 4-10 days after these flies were transferred to 27 degrees C. The implications for temperature effects on bluetongue epizootiology are discussed.

  10. 19 CFR 12.44 - Disposition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SPECIAL CLASSES OF MERCHANDISE Merchandise Produced by Convict, Forced, Or Indentured Labor § 12.44... proceedings pursuant to part 162, subpart E, of this chapter. (c) Prison-labor goods. Nothing in this chapter... concerning prison-labor goods. [T.D. 00-52, 65 FR 45875, July 26, 2000] ...

  11. 44 CFR 209.12 - Oversight and results.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Oversight and results. 209.12... Oversight and results. (a) FEMA oversight. Our Regional Administrators are responsible for overseeing this... they deem appropriate. (c) Program results. The State will review the effectiveness of approved...

  12. 44 CFR 209.12 - Oversight and results.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Oversight and results. 209.12... Oversight and results. (a) FEMA oversight. Our Regional Administrators are responsible for overseeing this... they deem appropriate. (c) Program results. The State will review the effectiveness of approved...

  13. 44 CFR 209.12 - Oversight and results.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Oversight and results. 209.12... Oversight and results. (a) FEMA oversight. Our Regional Administrators are responsible for overseeing this... they deem appropriate. (c) Program results. The State will review the effectiveness of approved...

  14. 44 CFR 209.12 - Oversight and results.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Oversight and results. 209.12... Oversight and results. (a) FEMA oversight. Our Regional Administrators are responsible for overseeing this... they deem appropriate. (c) Program results. The State will review the effectiveness of approved...

  15. 44 CFR 209.12 - Oversight and results.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Oversight and results. 209.12... Oversight and results. (a) FEMA oversight. Our Regional Administrators are responsible for overseeing this... they deem appropriate. (c) Program results. The State will review the effectiveness of approved...

  16. All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 9. Abilene, Kansas-Yarmouth, Maine.

    DTIC Science & Technology

    1987-01-01

    8217) 00) 00() W-4 4I 0C04 I CNNeNN".40 c.-4 c N C-4 cO -.4-40 C.40(co0~ C(O C.-4 C.4 C-4 I 00 I C-.4-4" "N 4c c .4 CN C O c ENc C-4-4< C.4-I.44C c - C-I C...34-N 04 >4 w 0 w104 -4 𔃾 1 (0O04 I E -4.4 -4,4< E-4 -4 4 EC’m ENc E -4 EN U MN m 00 .CD ’-4 CN4 = N 1I (O0004 W WW M ID~(0o WC~o .C4 .CI =(L =CC, us N...4000C4 0-44 0 0 0004 ’)n . enc (j -0 c0 0 7 3(0029 000- 00-44--C Z(co1-10- 4 0 4. 00001-< 0- 0q 0Nca co 0c 0 0m~ 00 00rc . nwu> UM )mmc 10 4 (. o r)00

  17. Climatic Conditions at Air Force Bases in Australia,

    DTIC Science & Technology

    1980-10-01

    U"- C 0 - 0 4 4.M57 c 04. %OOOli~ 0C On mm 14 - 4P , cC)r )Go - 4-) 0 to to r. C)C r44 C V 0 ca.. x . . 04 1 -4 r-G 0o .4 4= 1. -40 -4 ) 4 04 Ju~0 C: 04...8217 0 C) 4.-4S- 0) to 0) N 9 0 4-4 4 4 1-4 -4 .- 4 4 -4 4 0 .4 W ) $4 .f in0A . T - :T -’ s- 4P .-4 C.) cn c 4 C- - 00 m 0 F-44 m)0J- ~ )N U) " ) enp co o...cyclones causes problems in predictfng extreme gust speeds for coastal stations north of latitude 30*S as was discussed under Extreme Rainfall. As was

  18. Future precipitation changes over China under 1.5 °C and 2.0 °C global warming targets by using CORDEX regional climate models.

    PubMed

    Li, Huixin; Chen, Huopo; Wang, Huijun; Yu, Entao

    2018-06-01

    This study aims to characterize future changes in precipitation extremes over China based on regional climate models (RCMs) participating in the Coordinated Regional Climate Downscaling Experiment (CORDEX)-East Asia project. The results of five RCMs involved in CORDEX-East Asia project that driven by HadGEM2-AO are compared with the simulation of CMA-RegCM driven by BCC-CSM1.1. Eleven precipitation extreme indices that developed by the Expert Team on Climate Change Detection and Indices are employed to evaluate precipitation extreme changes over China. Generally, RCMs can reproduce their spatiotemporal characteristics over China in comparison with observations. For future climate projections, RCMs indicate that both the occurrence and intensity of precipitation extremes in most regions of China will increase when the global temperature increases by 1.5/2.0 °C. The yearly maximum five-day precipitation (RX5D) averaged over China is reported to increase by 4.4% via the CMA-RegCM under the 1.5 °C warming in comparison with the baseline period (1986-2005); however, a relatively large increase of 11.1% is reported by the multi-model ensemble median (MME) when using the other five models. Furthermore, the reoccurring risks of precipitation extremes over most regions of China will further increase due to the additional 0.5 °C warming. For example, RX5D will further increase by approximately 8.9% over NWC, 3.8% over NC, 2.3% over SC, and approximately 1.0% over China. Extremes, such as the historical 20-year return period event of yearly maximum one-day precipitation (RX1D) and RX5D, will become more frequent, with occurrences happening once every 8.8 years (RX1D) and 11.5 years (RX5D) under the 1.5 °C warming target, and there will be two fewer years due to the additional 0.5 °C warming. In addition, the intensity of these events will increase by approximately 9.2% (8.5%) under the 1.5 °C warming target and 12.6% (11.0%) under the 2.0 °C warming target for RX1D (RX5D). Copyright © 2018 Elsevier B.V. All rights reserved.

  19. A Review of Fatigue Crack Growth in Metallics at Low Stress Intensities.

    DTIC Science & Technology

    1983-01-01

    received R 0,35 * 257 C 2i 0*C b -sT 625C 0 0 10 0 ~1O90 co 0 C 2 2,5 3 4 5 67 8 910C12 15 20 A K MN rfiV2 Figure 31 The influence of test temperature...34 L.2. 11111 L25I MICROCOPY RESOLUTION TEST CHART NATIONAL. BUREAU OF STANDARDS 1963-A A 44-7 F 49620-82-C-0088 A REVIEW OF FATIGUE CRACK GROWTH IN...relation to the following variables, mean stress, yield stress, test temperature, test frequency, fatigue crack closure, microstructure, environment and

  20. Algicidal effects of four Chinese herb extracts on bloom-forming Microcystis aeruginosa and Chlorella pyrenoidosa.

    PubMed

    Ye, Liangtao; Qian, Jiazhong; Jin, Song; Zuo, Shengpeng; Mei, Hui; Ma, Suming

    2014-01-01

    Extracts from four Chinese herbs, Phellodendri chinensis cortex, Artemisia annua L., Scutellaria baicalensis G. and Citrus reticulate peel were tested for their algicidal effects on Microcystis aeruginosa and Chlorella pyrenoidosa. The results showed that M. aeruginosa was more susceptible than C. pyrenoidosa. The growth of M. aeruginosa was significantly inhibited (p < 0.05) by the four herb extracts. Among the four herbs, P. chinensis cortex and S. baicalensis had the greatest inhibitory effects on M. aeruginosa, followed by C reticulate peel and A. annua. The 50% effective concentrations (EC50) of S. baicalensis, P chinensis cortex, C. reticulate peel and A. annua were 0.87, 0.88, 5.27 and 1 1.16 gherb L-1, respectively. The growth of C. pyrenoidosa was moderately inhibited by the herb extracts individually. The EC5o concentrations for S. baicalensis, P. chinensis cortex, C. reticulate peel andA. annua were 8.67, 11.67, 12.81 and 12.44 g herb L-1', respectively. Extract from S. baicalensis displayed stronger algicidal effects on C. pyrenoidosa than the other three herbs, although no lethal effect on C. pyrenoidosa was observed during the cultivation period. Compared with corresponding individual extract at the same dosage, the binary mixtures of the four herb extracts enhanced the algicidal effects on M. aeruginosa. The maximum inhibitory rates of all binary mixtures of the four herb extracts were all above 92% during the 10-day incubation. The results demonstrate that Chinese herbs, such as P. chinensis cortex or S. baicalensis and their combinations, could offer an effective alternative for mitigating outbreaks of harmful algal blooms in water bodies.

  1. Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility: A meta-analysis

    PubMed Central

    Wei, Yong-Gang; Liu, Fei; Li, Bo; Chen, Xi; Ma, Yu; Yan, Lv-Nan; Wen, Tian-Fu; Xu, Ming-Qing; Wang, Wen-Tao; Yang, Jia-Yin

    2011-01-01

    AIM: To assess the association between Interleukin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility. METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for IL-10 polymorphisms and HCC were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta-analysis included seven eligible studies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32). CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. PMID:22025883

  2. Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.

    PubMed

    Kim, Haeyoung; Cho, Dae-Yeon; Choi, Doo Ho; Oh, Mijin; Shin, Inkyung; Park, Won; Huh, Seung Jae; Nam, Seok Jin; Lee, Jeong Eon; Kim, Seok Won

    2017-01-01

    This study was performed to evaluate the frequency of mutations in CHEK2, PALB2, MRE11, and RAD50 among Korean patients at high risk for hereditary breast cancer. A total of 235 Korean patients with hereditary breast cancer who tested negative for BRCA1/2 mutation were enrolled to this study. Entire coding regions of CHEK2, PALB2, MRE11, and RAD50 were analyzed using massively parallel sequencing (MPS). Sequence variants detected by MPS were confirmed by Sanger sequencing. Six patients (2.5 %) were found to have pathogenic variants in CHEK2 (n = 1), PALB2 (n = 2), MRE11 (n = 1), and RAD50 (n = 2). Among the pathogenic variants, PALB2 c.2257C>T was previously reported in other studies, while CHEK2 c.1245dupC, PALB2 c.1048C>T, MRE11 c.1773_1774delAA, RAD50 c.1276C>T, and RAD50 c.3811_3813delGAA were newly identified in this study. A total of 15 missense variants were found in the four genes among 26 patients; 7 patients had a variant in CHEK2, 11 in PALB2, 2 in MRE11, and 6 in RAD50. When in silico analyses were performed to the 15 missense variants, six variants (CHEK2 c.686A>G, PALB2 c.1492G>T, PALB2 c.3054G>C, MRE11 c.140C>T, RAD50 c.1456C>T, and RAD50 c.3790C>T) were predicted to be deleterious. Pathogenic variants in CHEK2, PALB2, MRE11, and RAD50 were detected in a small proportion of Korean patients with features of hereditary breast cancer.

  3. 44 CFR 63.11 - Requirement for a commitment before October 1, 1989.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.11...

  4. 44 CFR 63.11 - Requirement for a commitment before October 1, 1989.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.11...

  5. 44 CFR 63.11 - Requirement for a commitment before October 1, 1989.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.11...

  6. 44 CFR 63.11 - Requirement for a commitment before October 1, 1989.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.11...

  7. 44 CFR 63.11 - Requirement for a commitment before October 1, 1989.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.11...

  8. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 9. (H and H Meat Products, Inc.-Iannucci and Son Con.)

    DTIC Science & Technology

    1989-01-01

    8217 Cl - 4 enC )() COOIn-Mi I -4N(r4 N(\\J C C NN N lc04-. >N I 40(00 000 0 (NJ>om -4N(04L) 1 00 CIoOC ’o >0 0 I 20 0 0 Q n4 00 0 L ooQC IM 4(-4 C4 o a oI...1- Q( a ɘ ə a < LA-L-L) < 00(u0N D 0( W1 I’N D (D (DN 41 If 4( c I lle W M.-(--4.1000 U).- 4(D LA- LADO LA4 ( (0C 01.᝴ L -4 - 14-4 I-4 -4 -- of...Mooɜ IftVci 0I oU1 n107,I nL nI nI CaN InC) LALLAALL L -4 1.1Q(0 O C1(1Cim 1000 -00 1 f (D(0 f1 ENc nu nI nu )t nL)I r nI nu O L A L A L A L 10 C -i

  9. The p.Thr11Met mutation in c19orf12 is frequent among adult Turkish patients with MPAN.

    PubMed

    Olgiati, Simone; Doğu, Okan; Tufekcioglu, Zeynep; Diler, Yunus; Saka, Esen; Gultekin, Murat; Kaleagasi, Hakan; Kuipers, Demy; Graafland, Josja; Breedveld, Guido J; Quadri, Marialuisa; Sürmeli, Reyhan; Sünter, Gülin; Doğan, Tuğrul; Yalçın, Ayşe Destina; Bilgiç, Başar; Elibol, Bülent; Emre, Murat; Hanagasi, Hasmet A; Bonifati, Vincenzo

    2017-06-01

    Mutations in the C19orf12 gene cause mitochondrial membrane protein associated neurodegeneration (MPAN), an autosomal recessive form of neurodegeneration with brain iron accumulation (NBIA). A limited number of patients with C19orf12 mutations, particularly those with adult onset of symptoms, have been reported. We sequenced the entire coding region of C19orf12 in 15 Turkish adult probands with idiopathic NBIA. We also performed haplotype analysis in families with a recurrent C19orf12 mutation. Clinical features were collected using a standardized form. Nine of our 15 probands (60%) carried the homozygous c.32C > T mutation in C19orf12 (predicted protein effect: p.Thr11Met). This homozygous mutation co-segregated with the disease in all affected relatives available for testing (16 homozygous subjects). Haplotypes across the C19orf12 locus were identical for a very small region, closest to the mutation, suggesting an old founder, or, two independent founders. The clinical phenotype was characterized by adult onset in most cases (mean 24.5 years, range 10-36), and broad spectrum, including prominent parkinsonism, pyramidal signs, psychiatric disturbances, cognitive decline, and motor axonal neuropathy, in various combinations. On T2- or susceptibility weighted-MRI images, all patients displayed bilateral hypointensities in globus pallidus and substantia nigra, without an eye-of-the-tiger sign; however, hyperintense streaking of the medial medullary lamina between the external and internal parts of globus pallidus was observed frequently. The C19orf12 p.Thr11Met mutation is frequent among adult Turkish patients with MPAN. These findings contribute to the characterization of this important NBIA form, and have direct implications for genetic testing of patients of Turkish origin. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults

    PubMed Central

    Mangner, Tom J.; Leonard, William R.; Kumar, Ajay; Granneman, James G.

    2017-01-01

    Recent work in rodents has demonstrated that basal activity of the local sympathetic nervous system is critical for maintaining brown adipocyte phenotypes in classic brown adipose tissue (BAT) and white adipose tissue (WAT). Accordingly, we sought to assess the relationship between sympathetic innervation and cold-induced activation of BAT and WAT in lean young adults. Methods: Twenty adult lean normal subjects (10 women and 10 men; mean age ± SD, 23.3 ± 3.8 y; body mass index, 23.7 ± 2.5 kg/m2) underwent 11C-meta-hydroxyephedrin (11C-HED) and 15O-water PET imaging at rest and after exposure to mild cold (16°C) temperature. In addition, 18F-FDG images were obtained during the cold stress condition to assess cold-activated BAT mass. Subjects were divided into 2 groups (high BAT and low BAT) based on the presence of 18F-FDG tracer uptake. Blood flow and 11C-HED retention index (RI, an indirect measure of sympathetic innervation) were calculated from dynamic PET scans at the location of BAT and WAT. Whole-body daily energy expenditure (DEE) during rest and cold stress was measured by indirect calorimetry. Tissue level oxygen consumption (MRO2) was determined and used to calculate the contribution of cold-activated BAT and WAT to daily DEE. Results: 18F-FDG uptake identified subjects with high and low levels of cold-activated BAT mass (high BAT, 96 ± 37 g; low-BAT, 16 ± 4 g). 11C-HED RI under thermoneutral conditions significantly predicted 18F-FDG uptake during cold stress (R2 = 0.68, P < 0.01). In contrast to the significant increase of 11C-HED RI during cold in BAT (2.42 ± 0.85 vs. 3.43 ± 0.93, P = 0.02), cold exposure decreased the 11C-HED RI in WAT (0.44 ± 0.22 vs. 0.41 ± 0.18) as a consequence of decreased perfusion (1.22 ± 0.20 vs. 1.12 ± 0.16 mL/100 g/min). The contribution of WAT to whole-body DEE was approximately 150 kcal/d at rest (149 ± 52 kcal/d), which decreased to approximately 100 kcal/d during cold (102 ± 47 kcal/d). Conclusion: The level of sympathetic innervation, as determined by 11C-HED RI, can predict levels of functional BAT. Overall, blood flow is the best independent predictor of 11C-HED RI and 18F-FDG uptake across thermoneutral and cold conditions. In contrast to BAT, cold stress reduces blood flow and 18F-FDG uptake in subcutaneous WAT, indicating that the physiologic response is to reduce heat loss rather than to generate heat. PMID:27789721

  11. Five-year National Surveillance of Invasive Candidiasis: Species Distribution and Azole Susceptibility from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study.

    PubMed

    Xiao, Meng; Sun, Zi-Yong; Kang, Mei; Guo, Da-Wen; Liao, Kang; Chen, Sharon C-A; Kong, Fanrong; Fan, Xin; Cheng, Jing-Wei; Hou, Xin; Zhou, Meng-Lan; Li, Ying; Yu, Shu-Ying; Huang, Jing-Jing; Wang, He; Xu, Ying-Chun

    2018-05-09

    Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility of Candida isolates in China are still limited. Here we report surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. Sixty-five tertiary hospitals collected 8,829 Candida isolates from August 1, 2009 to July 31, 2014. Matrix-assisted laser desorption/ionization -time of flight mass spectrometry supplemented by rDNA sequencing was used to define species, and fluconazole and voriconazole susceptibilities determined by the Clinical and Laboratory Standards Institute disk diffusion method. A total of 32 Candida species were identified. C. albicans was the most common species (44.9%) followed by C. parapsilosis complex (20.0%), C. tropicalis (17.2%) and C. glabrata complex (10.8%), with other species comprising <3%. However, in candidemia, the proportion of cases caused by C. albicans was only 32.3%. C. albicans and C. parapsilosis complex isolates were susceptible to fluconazole and voriconazole (<6% resistance), while fluconazole- and azole cross-resistant rates were high in C. tropicalis (13.3% and 12.9%), C. glabrata complex (18.7% and 14%) and uncommon Candida species (44.1% and 10.3%) isolates. Moreover, from year 1 to 5 of the study, there was a significant increase in resistant rates amongst C. glabrata complex isolates to fluconazole (12.2% to 24.0%), and amongst C. tropicalis isolates to both fluconazole (5.7% to 21.0%) and voriconazole (5.7% to 21.4%) (all P<0.01). Geographic variations in causative species and susceptibilities were noted. Our findings indicated that antifungal resistance have become noteworthy in China, and enhanced surveillance is warranted. Copyright © 2018 American Society for Microbiology.

  12. Development of a Physical Employment Testing Battery for Infantry Soldiers: 11B Infantryman and 11C Infantryman - Indirect Fire

    DTIC Science & Technology

    2015-12-01

    25mm barrel install (Task 5) and engage targets with an M2 machine gun (Task 12). During these tasks, the performance of one individual will affect...TOW Missile Launcher on BFV (Task 8) 43 1.9 Images of Move Under Direct Fire (Task 10) 44 1.10 Engage Targets with a .50 Caliber M2 Machine Gun ...Engage Targets with a .50 Caliber M2 Machine Gun While wearing a fighting load (approximately 83 lb) and working as a member of a two-person team

  13. Prepare and Evaluate an Organizational Relocation Plan.

    DTIC Science & Technology

    1980-04-01

    t’V 1 ’ - 2 .C W 040 Cu 41O1g~~ 5.h * 05- CA a.c44 0 - Q V 041UU .0. 2-24 - -m ZCUC .4t Z- 4Ś- .4L .. C4 Q E 41. u-I C .. .0 Me WWE QE MECLt 3 ow...family needs. 10. Establish accounting procedures to record the use of resources, goods and services. 11. Provide access to counseling. Health and Medical...governments, supported by Federal agencies and by participating private organizations, will be responsible for law enforcement, health , welfare, and other

  14. A False-Negative Case of Primary Central Nervous System Lymphoma on 11C-Methionine PET and Intense 18F-FDG Uptake.

    PubMed

    García-Garzon, J R; Villasboas-Rosciolesi, Diego; Baquero, Miguel; Bassa, Pere; Soler, Marina; Riera, Eduard

    2016-08-01

    We report a case of a 44-year-old man with neurological symptoms and MRI findings, which were unable to differentiate between glioma and lymphoma. Metabolic characterization by means of PET imaging with F-FDG and C-methionine is proposed to determine the benign or tumor (high- and low-grade) origin of brain lesions. In this case, the MRI lesion corresponded with an inconclusive metabolic pattern of intense F-FDG uptake and no significant C-methionine uptake. Pathological study revealed a false-negative case of C-methionine due to lymphoma.

  15. Crystal structures of 4-meth­oxy­benzoic acid–1,3-bis­(pyridin-4-yl)propane (2/1) and biphenyl-4,4′-di­carb­oxy­lic acid–4-meth­oxy­pyridine (1/2)

    PubMed Central

    Gotoh, Kazuma; Ishida, Hiroyuki

    2017-01-01

    The crystal structures of two hydrogen-bonded compounds, namely 4-meth­oxy­benzoic acid–1,3-bis­(pyridin-4-yl)propane (2/1), C13H14.59N2·C8H7.67O3·C8H7.74O3, (I), and biphenyl-4,4′-di­carb­oxy­lic acid–4-meth­oxy­pyridine (1/2), C14H9.43O4·C6H7.32NO·C6H7.25NO, (II), have been determined at 93 K. In (I), the asymmetric unit consists of two crystallographically independent 4-meth­oxy­benzoic acid mol­ecules and one 1,3-bis­(pyridin-4-yl)propane mol­ecule. The asymmetric unit of (II) comprises one biphenyl-4,4′-di­carb­oxy­lic acid mol­ecule and two independent 4-meth­oxy­pyridine mol­ecules. In each crystal, the acid and base mol­ecules are linked by short O—H⋯N/N—H⋯O hydrogen bonds, in which H atoms are disordered over the acid O-atom and base N-atom sites, forming a linear hydrogen-bonded 2:1 or 1:2 unit of the acid and the base. The 2:1 units of (I) are linked via C—H⋯π, π–π and C—H⋯O inter­actions into a tape structure along [101], while the 1:2 units of (II) form a double-chain structure along [-101] through π–π and C—H⋯O inter­actions. PMID:28932435

  16. 12 CFR 215.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...(h) of the Federal Reserve Act (12 U.S.C. 248(a), 375a, and 375b), 12 U.S.C. 1817(k), section 306 of... 12 Banks and Banking 2 2013-01-01 2013-01-01 false Authority, purpose, and scope. 215.1 Section... (1991)), section 11 of the Home Owners' Loan Act (12 U.S.C. 1468), and section 312(b)(2)(A) of the Dodd...

  17. 12 CFR 215.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...(h) of the Federal Reserve Act (12 U.S.C. 248(a), 375a, and 375b), 12 U.S.C. 1817(k), section 306 of... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Authority, purpose, and scope. 215.1 Section... (1991)), section 11 of the Home Owners' Loan Act (12 U.S.C. 1468), and section 312(b)(2)(A) of the Dodd...

  18. 12 CFR 215.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(h) of the Federal Reserve Act (12 U.S.C. 248(a), 375a, and 375b), 12 U.S.C. 1817(k), section 306 of... 12 Banks and Banking 2 2012-01-01 2012-01-01 false Authority, purpose, and scope. 215.1 Section... (1991)), section 11 of the Home Owners' Loan Act (12 U.S.C. 1468), and section 312(b)(2)(A) of the Dodd...

  19. Astrophysical SE2 factor of the 12C(α, γ)16O reaction through the 12C(11B, 7Li)16O transfer reaction

    NASA Astrophysics Data System (ADS)

    Guo, B.; Du, X. C.; Li, Z. H.; Li, Y. J.; Pang, D. Y.; Su, J.; Yan, S. Q.; Fan, Q. W.; Gan, L.; Han, Z. Y.; Li, E. T.; Li, X. Y.; Lian, G.; Liu, J. C.; Pei, C. J.; Qiao, L. H.; Shen, Y. P.; Su, Y.; Wang, Y. B.; Zeng, S.; Zhou, Y.; Liu, W. P.

    2016-02-01

    The 12C(α, γ)16O reaction plays a key role in the evolution of stars with masses of M > 0.55 M⊙. At the Gamow peak (Ec.m. = 300 ke V, T9 = 0.2), the cross section of the 12C(α, γ)16O reaction is so small (about 10-17 barn) that the direct measurement in ground laboratory is not feasible with the existing technology. Up to now, the cross sections at lower energies can only be extrapolated from the data at higher energies. However, two subthreshold resonances, locating at Ex = 7.117 MeV and Ex = 6.917 MeV, make this extrapolation more complicated. In this work the 6.917 MeV subthreshold resonance in the 12C(α, γ)16O reaction was investigated via the 12C(11B, 7Li)16O reaction. The experiment was performed using the Q3D magnetic spectrograph at HI-13 tandem accelerator. We measured the angular distribution of the 12C(11B, 7Li)16O transfer reaction leading to the 6.917 MeV state. Based on DWBA analysis, we derived the square of ANC of the 6.917 MeV level in 16O to be (2.45± 0.28) ×1010 fm-1, with which the reduced-α width can be computed. Finally, we calculated the astrophysical SE2 factor of the 6.917 MeV resonance to be 67.6 ± 7.7 ke V b.

  20. An Investigation of the Feasibility of Implementing Substantial Finite Element Codes on Popular Microcomputers.

    DTIC Science & Technology

    1982-10-01

    u~ - ii 256, Ca a- N N :3 z La11) LDw E 00 -- w ’.44 wL ) w w -- CL a - I.- (0.a) J.-O0 1-0 33 ~0 0-4 30 3 C14 04. V)V) zwI w r cd~~ - E L I-c;44x...J . 2 .La I I I I I I I I I w I LM- z 0 = W LL W z z 0r W 1-4 Eflu inz 0- 0 c r zz w a 0 "WWL 4-"I’ )V ’ 1-m a LM a 0 -j (Z r 0o oz z . 281 w N4 0n N

  1. 30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...), (g), (h), .38; 784.27; 800.11(b)(2); 815.15(c)(2), (3), (4), .17(a), (b); 816.49(b)(7), (c)(2), .84(b..., 1983 March 16, 1984 ASCMRC 771.25 (a)(2); 776(c)(1), (2), (4), (5)(i), (ii); 842(c). May 21, 1985...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

  2. Isolation and characterization of pediocin AcH chimeric protein mutants with altered bactericidal activity.

    PubMed

    Miller, K W; Schamber, R; Osmanagaoglu, O; Ray, B

    1998-06-01

    A collection of pediocin AcH amino acid substitution mutants was generated by PCR random mutagenesis of DNA encoding the bacteriocin. Mutants were isolated by cloning mutagenized DNA into an Escherichia coli malE plasmid that directs the secretion of maltose binding protein-pediocin AcH chimeric proteins and by screening transformant colonies for bactericidal activity against Lactobacillus plantarum NCDO955 (K. W. Miller, R. Schamber, Y. Chen, and B. Ray, 1998. Appl. Environ. Microbiol. 64:14-20, 1998). In all, 17 substitution mutants were isolated at 14 of the 44 amino acids of pediocin AcH. Seven mutants (N5K, C9R, C14S, C14Y, G37E, G37R, and C44W) were completely inactive against the pediocin AcH-sensitive strains L. plantarum NCDO955, Listeria innocua Lin11, Enterococcus faecalis M1, Pediococcus acidilactici LB42, and Leuconostoc mesenteroides Ly. A C24S substitution mutant constructed by other means also was inactive against these bacteria. Nine other mutants (K1N, W18R, I26T, M31T, A34D, N41K, H42L, K43N, and K43E) retained from <1% to approximately 60% of wild-type activity when assayed against L. innocua Lin11. One mutant, K11E, displayed approximately 2. 8-fold-higher activity against this indicator. About one half of the mutations mapped to amino acids that are conserved in the pediocin-like family of bacteriocins. All four cysteines were found to be required for activity, although only C9 and C14 are conserved among pediocin-like bacteriocins. Several basic amino acids as well as nonpolar amino acids located within the hydrophobic C-terminal region also were found to be important. The mutations are discussed in the context of structural models that have been proposed for the bacteriocin.

  3. Kinetics study of the reaction of OH radicals with C5-C8 cycloalkanes at 240-340 K using the relative rate/discharge flow/mass spectrometry technique.

    PubMed

    Singh, Sumitpal; de Leon, Maria Fatima; Li, Zhuangjie

    2013-10-24

    Rate constants of reactions of hydroxyl radical with cyclopentane (k1), cyclohexane (k2), cycloheptane (k3), and cyclooctane (k4) have been acquired at 240-340 K and a total pressure of about 1 Torr using the technique of relative rate combined with discharge flow and mass spectrometry (RR/DF/MS). At 298 K, the rate constants are determined using two reference compounds, which are averaged to be k1 = (4.81 ± 0.88) × 10(-12), k2 = (6.41 ± 0.85) × 10(-12), k3 = (10.30 ± 1.44) × 10(-12), and k4 = (1.42 ± 0.27) × 10(-11) cm(3) molecule(-1) s(-1). The Arrhenius expressions at 240-340 K for these reactions are determined to be k1(T) = (2.43 ± 0.50) × 10(-11)exp[-(481 ± 58)/T], k2(T) = (3.96 ± 0.60) × 10(-11)exp[-554 ± 42)/T], k3(T) = (5.74 ± 0.66) × 10(-11)exp[-527 ± 33)/T], and k4(T) = (1.12 ± 0.21) × 10(-10)exp[-626 ± 53)/T]. Using the kcycloalkane+OH(277 K) values measured in the present work, the atmospheric lifetime for cyclopentane, cyclohexane, cycloheptane, and cyclooctane is estimated to be about 78, 64, 38, and 29 h, respectively.

  4. Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer.

    PubMed

    Mandir, N; Goodlad, R A

    2008-04-01

    Dietary conjugated linoleic acids (CLA) have had many health benefits claimed for them, including antineoplastic actions. The effects of the predominant forms of CLA, namely the c9t11 and t10c12 isomers, or a mixture of these on polyp development, were investigated in the Apc(Min/+) mouse. CLAs have also been linked to altered rates of cell renewal and cell proliferation so this was also studied, as was a further means of increasing tissue mass, namely crypt fission. The stomach and small intestine were significantly heavier in the t10c12, and in the mixture-treated groups (P < 0.001). Crypt fission was increased in the middle small intestine by the t10c12 diet while colonic weight was reduced by c9t11 provision and crypts were 20% shorter. The t10c12 and the mixture significantly reduced polyp number in the proximal small intestine but they increased polyp diameter in the middle and distal small intestine, to an extent that the polyp burden was significantly increased at these sites. All CLAs significantly reduced polyp number in the colon, but the mixture significantly increased polyp diameter in the colon. Increased polyp diameter associated with t10c12 diet and especially with the mixture is a cause of concern, as this is the commercially available form. The naturally occurring isomer, c9t11 decreased colonic polyp number and did not increase diameter, suggesting that this natural isomer is the most likely to be protective.

  5. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells.

    PubMed

    Zhong, Wu; Zhu, Haichuan; Sheng, Fugeng; Tian, Yonglu; Zhou, Jun; Chen, Yingyu; Li, Song; Lin, Jian

    2014-07-01

    Transition metal copper (Cu) can exist in oxidized or reduced states in cells, leading to cytotoxicity in cancer cells through oxidative stress. Recently, copper complexes are emerging as a new class of anticancer compounds. Here, we report that a novel anticancer copper complex (HYF127c/Cu) induces oxidative stress-dependent cell death in cancer cells. Further, transcriptional analysis revealed that oxidative stress elicits broad transcriptional changes of genes, in which autophagy-related genes are significantly changed in HYF127c/Cu-treated cells. Consistently, autophagy was induced in HYF127c/Cu-treated cells and inhibitors of autophagy promoted cell death induced by HYF127c/Cu. Further analysis identified that the MAPK11/12/13/14 (formerly known as p38 MAPK) pathway was also activated in HYF127c/Cu-treated cells. Meanwhile, the MAPK11/12/13/14 inhibitor SB203580 downregulated autophagy by inhibiting the transcription of the autophagy genes MAP1LC3B, BAG3, and HSPA1A, and promoted HYF127c/Cu-induced cell death. These data suggest that copper-induced oxidative stress will induce protective autophagy through transcriptional regulation of autophagy genes by activation of the MAPK11/12/13/14 pathway in HeLa cells.

  6. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4′-bis­[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis­{3-[(S)-2-methyl­pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1′-biphen­yl

    PubMed Central

    Wan, Anqi; Penthala, Narsimha Reddy; Fifer, E. Kim; Parkin, Sean; Crooks, Peter A.

    2015-01-01

    The title compounds, C26H28N2, (I), and C28H32N2, (II), were designed based on the structure of the potent α9α10 nicotinic acetyl­choline receptor antagonist ZZ161C {1,1′-[[1,1′-biphen­yl]-4,4′-diylbis(prop-2-yne-3,1-di­yl)]bis­(3,4-di­methyl­pyridin-1-ium) bromide}. In order to improve the druglikeness properties of ZZ161C for potential oral administration, the title compounds (I) and (II) were prepared by coupling 4,4′-bis­(3-bromo­prop-1-yn-1-yl)-1,1′-biphenyl with pyrrol­idine, (I), and (S)-2-methyl­pyrrolidine, (II), respectively, in aceto­nitrile at room temperature. The asymmetric unit of (I) contains two half mol­ecules that each sit on sites of crystallographic inversion. As a result, the biphenyl ring systems in compound (I) are coplanar. The biphenyl ring system in compound (II), however, has a dihedral angle of 28.76 (11)°. In (I), the two independent mol­ecules differ in the orientation of the pyrrolidine ring (the nitro­gen lone pair points towards the biphenyl rings in one mol­ecule, but away from the rings in the other). The torsion angles about the ethynyl groups between the planes of the phenyl rings and the pyrrolidine ring N atoms are 84.15 (10) and −152.89 (10)°. In compound (II), the corresponding torsion angles are 122.0 (3) and 167.0 (3)°, with the nitro­gen lone pairs at both ends of the mol­ecule directed away from the central biphenyl rings. PMID:26594393

  7. Effect of Galacto-Oligosaccharides: Maltodextrin Matrices on the Recovery of Lactobacillus plantarum after Spray-Drying

    PubMed Central

    Sosa, Natalia; Gerbino, Esteban; Golowczyc, Marina A.; Schebor, Carolina; Gómez-Zavaglia, Andrea; Tymczyszyn, E. Elizabeth

    2016-01-01

    In this work maltodextrins were added to commercial galacto-oligosaccharides (GOS) in a 1:1 ratio and their thermophysical characteristics were analyzed. GOS:MD solutions were then used as matrices during spray-drying of Lactobacillus plantarum CIDCA 83114. The obtained powders were equilibrated at different relative humidities (RH) and stored at 5 and 20°C for 12 weeks, or at 30°C for 6 weeks. The Tgs of GOS:MD matrices were about 20–30°C higher than those of GOS at RH within 11 and 52%. A linear relation between the spin-spin relaxation time (T2) and T-Tg parameter was observed for GOS:MD matrices equilibrated at 11, 22, 33, and 44% RH at 5, 20, and 30°C. Spray-drying of L. plantarum CIDCA 83114 in GOS:MD matrices allowed the recovery of 93% microorganisms. In contrast, only 64% microorganisms were recovered when no GOS were included in the dehydration medium. Survival of L. plantarum CIDCA 83114 during storage showed the best performance for bacteria stored at 5°C. In a further step, the slopes of the linear regressions provided information about the rate of microbial inactivation for each storage condition (k values). This information can be useful to calculate the shelf-life of spray-dried starters stored at different temperatures and RH. Using GOS:MD matrices as a dehydration medium enhanced the recovery of L. plantarum CIDCA 83114 after spray-drying. This strategy allowed for the first time the spray-drying stabilization of a potentially probiotic strain in the presence of GOS. PMID:27199918

  8. Mediation by prostaglandins of the stimulatory effect of substance P on cyclic AMP production in dog iris sphincter smooth muscle.

    PubMed

    Marathe, G K; Yousufzai, S Y; Abdel-Latif, A A

    1996-10-25

    The purpose of the present study was to examine the mechanism of the stimulatory effect of substance P (SP) on cyclic AMP (cAMP) accumulation in dog iris sphincter. We found that: (1) SP increased cAMP accumulation in a time- and concentration-dependent manner, the T1/2 and EC50 values being 1.2 min and 44 nM, respectively. SP has no effect on inositol trisphosphate and muscle contraction in this tissue. (2) SP-stimulated cAMP formation was inhibited by quinacrine, a non-specific phospholipase A2 inhibitor (IC50 = 9.5 microM), and by indomethacin (Indo), a cyclooxygenase inhibitor (IC50 = 3.5 nM), in a concentration-dependent manner, suggesting that SP induces cAMP accumulation via an Indo-sensitive pathway. (3) SP-induced arachidonic acid release and SP-induced prostaglandin E2 (PGE2) release were inhibited concentration dependently by quinacrine and Indo, with IC50 values of 11 microM and 0.8 nM, respectively. (4) PGE2 (1 microM) increased cAMP formation in the sphincter muscle by 94%, and, furthermore, the PG, but not SP, stimulated the activity of adenylyl cyclase in membrane fractions isolated from this tissue. (5) Indo (1 microM) blocked the relaxing effect of SP (1 microM) in iris sphincter precontracted with carbachol (1 microM). (6) The inhibitory effect of Indo on SP-induced cAMP accumulation was species specific. Increases in cAMP represent a mechanism by which extracellular SP can regulate smooth muscle function. Thus, we conclude from these studies that in dog iris sphincter SP-induced cAMP accumulation is mediated through PGs, and that in this cholinergically innervated muscle SP via cAMP could function, in part, to modulate the physiological responses to muscarinic receptor stimulation.

  9. Paraquat Resistance in Conyza1

    PubMed Central

    Fuerst, E. Patrick; Nakatani, Herbert Y.; Dodge, Alan D.; Penner, Donald; Arntzen, Charles J.

    1985-01-01

    A biotype of Conyza bonariensis (L.) Cronq. (identical to Conyza linefolia in other publications) originating in Egypt is resistant to the herbicide 1,1′-dimethyl-4,4′-bipyridinium ion (paraquat). Penetration of the cuticle by [14C]paraquat was greater in the resistant biotype than the susceptible (wild) biotype; therefore, resistance was not due to differences in uptake. The resistant and susceptible biotypes were indistinguishable by measuring in vitro photosystem I partial reactions using paraquat, 6,7-dihydrodipyrido [1,2-α:2′,1′-c] pyrazinediium ion (diquat), or 7,8-dihydro-6H-dipyrido [1,2-α:2′,1′-c] [1,4] diazepinediium ion (triquat) as electron acceptors. Therefore, alteration at the electron acceptor level of photosystem I is not the basis for resistance. Chlorophyll fluorescence measured in vivo was quenched in the susceptible biotype by leaf treatment with the bipyridinium herbicides. Resistance to quenching of in vivo chlorophyll fluorescence was observed in the resistant biotype, indicating that the herbicide was excluded from the chloroplasts. Movement of [14C] paraquat was restricted in the resistant biotype when excised leaves were supplied [14C]paraquat through the petiole. We propose that the mechanism of resistance to paraquat is exclusion of paraquat from its site of action in the chloroplast by a rapid sequestration mechanism. No differential binding of paraquat to cell walls isolated from susceptible and resistant biotypes could be detected. The exact site and mechanism of paraquat binding to sequester the herbicide remains to be determined. Images Fig. 6 PMID:16664176

  10. Hydride CVD Hetero-epitaxy of B 12P 2 on 4H-SiC

    DOE PAGES

    Frye, C. D.; Saw, C. K.; Padavala, Balabalaji; ...

    2016-11-27

    Icosahedral boron phosphide (B 12P 2) is a wide bandgap semiconductor (3.35 eV) that has been reported to “self-heal” from high-energy electron bombardment, making it attractive for potential use in radioisotope batteries, radiation detection, or in electronics in high radiation environments. Our study focused on improving B 12P 2 hetero-epitaxial films by growing on 4H-SiC substrates over the temperature range of 1250–1450 °C using B 2H 6 and PH 3 precursors in a H 2 carrier gas. Furthermore, XRD scans and Laue transmission photographs revealed that the epitaxial relationship was (0001)<11more » $$\\bar{2}$$0> B12P2|| (0001)<11$$\\bar{2}$$0> 4H-SiC. The film morphology and crystallinity were investigated as a function of growth temperature and growth time. At 1250 °C, films tended to form rough, polycrystalline layers, but at 1300 and 1350 °C, films were continuous and comparatively smooth (R RMS≤7 nm). At 1400 or 1450 °C, the films grew in islands that coalesced as the films became thicker. Using XRD rocking curves to evaluate the crystal quality, 1300 °C was the optimum growth temperature tested. Finally, at 1300 °C, the rocking curve FWHM decreased with increasing film thickness from 1494 arcsec for a 1.1 μm thick film to 954 arcsec for a 2.7 µm thick film, suggesting a reduction in defects with thickness.« less

  11. Hydride CVD Hetero-epitaxy of B 12P 2 on 4H-SiC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frye, C. D.; Saw, C. K.; Padavala, Balabalaji

    Icosahedral boron phosphide (B 12P 2) is a wide bandgap semiconductor (3.35 eV) that has been reported to “self-heal” from high-energy electron bombardment, making it attractive for potential use in radioisotope batteries, radiation detection, or in electronics in high radiation environments. Our study focused on improving B 12P 2 hetero-epitaxial films by growing on 4H-SiC substrates over the temperature range of 1250–1450 °C using B 2H 6 and PH 3 precursors in a H 2 carrier gas. Furthermore, XRD scans and Laue transmission photographs revealed that the epitaxial relationship was (0001)<11more » $$\\bar{2}$$0> B12P2|| (0001)<11$$\\bar{2}$$0> 4H-SiC. The film morphology and crystallinity were investigated as a function of growth temperature and growth time. At 1250 °C, films tended to form rough, polycrystalline layers, but at 1300 and 1350 °C, films were continuous and comparatively smooth (R RMS≤7 nm). At 1400 or 1450 °C, the films grew in islands that coalesced as the films became thicker. Using XRD rocking curves to evaluate the crystal quality, 1300 °C was the optimum growth temperature tested. Finally, at 1300 °C, the rocking curve FWHM decreased with increasing film thickness from 1494 arcsec for a 1.1 μm thick film to 954 arcsec for a 2.7 µm thick film, suggesting a reduction in defects with thickness.« less

  12. The contribution of dairy products to micronutrient intake in the Netherlands.

    PubMed

    Vissers, Pauline A J; Streppel, Martinette T; Feskens, Edith J M; de Groot, Lisette C P G M

    2011-10-01

    To assess the contribution of dairy products to the intake of various vitamins and minerals in several life stages in the Dutch population. Data from 3 Dutch Food Consumption Surveys and the Leiden Longevity Study were used to estimate the contribution of dairy products--as percentage of total intake--to the intake of iron, copper, selenium, zinc, calcium, folic acid, vitamin D, vitamin C, and vitamin B(12). In young children, dairy products contributed substantially to the intake of calcium (73%), selenium (21%), iron (8%), zinc (39%), copper (12%), folic acid (24%), vitamin C (18%), vitamin D (16%), and vitamin B(12) (58%). Of all dairy products, milk contributed the most to the intake of these nutrients. In adults and elderly subjects, the contribution of dairy products to total micronutrient intake was 65%-68% for calcium, 18%-19% for selenium, 3%-4% for iron, 28%-31% for zinc, 6%-7% for copper, 17%-19% for folic acid, 10%-14% for vitamin C, 11%-16% for vitamin D, and 44%-46% for vitamin B(12). Milk as well as cheese contributed the most to the intake of these nutrients. Dairy products are an important source of vitamins and minerals in the Dutch population. Dairy products, especially milk and cheese, contribute substantially to the intake of calcium, selenium, zinc, and vitamin B(12).

  13. Stellar reaction rate for {sup 22}Mg+p->{sup 23}Al from the asymptotic normalization coefficient in the mirror nuclear system {sup 22}Ne+n->{sup 23}Ne

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Al-Abdullah, T.; Physics Department, Hashemite University, Zarqa 13115; Carstoiu, F.

    2010-03-15

    The production of {sup 22}Na in ONe novae can be influenced by the {sup 22}Mg(p,gamma){sup 23}Al reaction. To investigate this reaction rate at stellar energies, we have determined the asymptotic normalization coefficient (ANC) for {sup 22}Mg+p->{sup 23}Al through measurements of the ANCs in the mirror nuclear system {sup 22}Ne+n->{sup 23}Ne. The peripheral neutron-transfer reactions {sup 13}C({sup 12}C,{sup 13}C){sup 12}C and {sup 13}C({sup 22}Ne,{sup 23}Ne){sup 12}C were studied. The identical entrance and exit channels of the first reaction make it possible to extract independently the ground-state ANC in {sup 13}C. Our experiment gives C{sub p{sub 1/2}}{sup 2}({sup 13}C)=2.24+-0.11 fm{sup -1}, whichmore » agrees with the value obtained from several previous measurements. The weighted average for all the obtained C{sub p{sub 1/2}}{sup 2} is 2.31+-0.08 fm{sup -1}. This value is adopted to be used in obtaining the ANCs in {sup 23}Ne. The differential cross sections for the reaction {sup 13}C({sup 22}Ne,{sup 23}Ne){sup 12}C leading to the J{sup {pi}}=5/2{sup +} and 1/2{sup +} states in {sup 23}Ne have been measured at 12 MeV/u. Optical model parameters for use in the DWBA calculations were obtained from measurements of the elastic scatterings {sup 22}Ne+{sup 13}C and {sup 22}Ne+{sup 12}C. The extracted ANC for the ground state in {sup 23}Ne, C{sub d{sub 5/2}}{sup 2}=0.86+-0.08+-0.12 fm{sup -1}, is converted to its corresponding value in {sup 23}Al using mirror symmetry to give C{sub d{sub 5/2}}{sup 2}({sup 23}Al)=(4.63+-0.77)x10{sup 3} fm{sup -1}. The astrophysical S factor S(0) for the {sup 22}Mg(p,gamma) reaction was determined to be 0.96+-0.11 keV b. The consequences for nuclear astrophysics are discussed.« less

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanchez, G.P.

    The interactions of a CH = CH target with a 29-Mev He/sup 3/ particles beam were analyzed. The results for elastic and inelastic processes C/sup 12/(He/ sup 3/, He/sup 3/)C/sup 12/ C/sup 12/(He/sup 3/ He/sup 3/)C/sup -12/ C/sup 12/(He/ sup 3/, alpha )C/sup 11/, C/sup 12/(He/sup 3/, d)N/sup 13/, and H/sup 1/(He/sup 3/, He/sup 3/)H/sup 1/ are presented. For the interaction radius, a value of 5.35 plus or minus 0.24 fermis was obtained by the black disk formula. The observed angular distributions were compared, when possible, with the predictions of Blair and A.B.M. direct interaction theories. The angular distributions formore » the elastic scattering of He/sup 3/ by H/sup 1/ was checked with theoretical predictions based on the resonating group theory. (auth)« less

  15. [Stress test at 44 °C and 80 % of humidity and usefulness of ice suit].

    PubMed

    González-Hidalgo, Germán; Sánchez-Flores, Hafid; López-Castellanos, Guillermo

    2011-01-01

    to compare the fatigue in a stress test at high temperature and humidity in eight healthy volunteers. the time of pedaling on the ergometer cycle was measured to know the exercise's efficiency at 30 km/h until the volunteers presented exhaustion or their heart frequency increased to > 160 beats/min. A basal test in the tunnel's ventilation of the Naica mine at 37.5°C and 40 % humidity was done. We repeated the stress test at the entrance of the cave, where temperature was 44°C and 80 % humidity. We compared using the protector equipment with ice and cold air breathing suit. the stress test al 44°C and 80 % humidity with the protector suit was interrupted in 75 % of participants because of an increase in the heart frequency (> 160 per minute) The exercise time was duplicated in 62 % and was increased in 100% of the participants with an average increase of 2.25 times and a rank of (1.12-3.3). Using the statistical Wilcoxon test the differences between the times of stress test with and without equipment at 44°C and 80 % humidity had a Z of 2.52 and a p of .012 was done.

  16. All Prime Contract Awards by State or Country, Place and Contractor. Part 7. (Aiea, Hawaii-Zion, Illinois)

    DTIC Science & Technology

    1989-01-01

    000 oao 0000 ’ 0 10 1 a I 0> I 01300011N 1 in 21 14-4 4140 (D 0 0 N1 -4 U) C1) (n N W I U)rK>U 11 0-4 -44-4-4 q-4 0-4-4-4 0.4 -4-4 0.-I 44O N N N in...4 if4-00 )r )(O c 00 -4 00 NO 0M 04 ,P-4 (4M (07) (0 r- on 1,-4 144(I0M4 if4-4 ."(-10 t VI = 141 Mx 00 Ni 20 4441 00 M 1 V 00 N 00 < 4140 ) I(0-4l if 4...00 4 44 It -0440 M 0 100 0 100 I0 (10 000000 140000 4140 MOO w- SI - x M fit0 mI M0 -40 1-400 -4 I -0 .n Z-400 0 0 -40 󈧬 045 I4’ (04 II .-4N 0 c

  17. Effects of conjugated linoleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet.

    PubMed

    Navarro, V; Zabala, A; Macarulla, M T; Fernández-Quintela, A; Rodríguez, V M; Simón, E; Portillo, M P

    2003-09-01

    Conjugated linoleic acid (CLA) refers to a mixture of naturally occurring positional and geometric isomers of linoleic acid that exist in dairy products and meat. The aim of the present work was to study the effects of c-9,t-11 and t-10,c-12 CLA isomers on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. Hamsters were divided in four groups: one group was fed a chow diet (control) and the other three groups were given semi-purified atherogenic diets with 0.5% linoleic acid (LA), c-9,t-11 or t-10,c-12 CLA. Body weight and food intake were measured daily. After 6 weeks, adipose tissues from different anatomical locations and liver were dissected and weighed. Serum glucose, total cholesterol, HDL-c, LDL-c and triacylglycerol levels, as well as total and free cholesterol, triacylglycerol and phospholipid content in liver were determined by enzymatic methods. No differences in either energy intake or final body weight were found. The addition of t-10,c-12 CLA reduced fat accumulation and led to lower serum cholesterol, as compared with LA group. Nevertheless the level remained higher than in the control animals. The reduction in serum cholesterol was limited to LDL-c. This isomer also reduced triacylglycerol content in liver but did not modify serum triacylglycerol level. In summary, the present study demonstrates that t-10,c-12 CLA is the biologically active agent when anti-obesity and hypocholesterolaemic properties of CLA are considered. In contrast, the isomer c-9,t-11 has no effect on lipid metabolism in hamsters.

  18. 49 CFR 376.12 - Written lease requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... forth in subpart C of this part, the written lease required under § 376.11(a) shall contain the... required by § 376.11(b). (c) Exclusive possession and responsibilities. (1) The lease shall provide that... required by paragraph (c)(1) of this section apply only during the time the equipment is operated by or for...

  19. 49 CFR 376.12 - Written lease requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... forth in subpart C of this part, the written lease required under § 376.11(a) shall contain the... required by § 376.11(b). (c) Exclusive possession and responsibilities. (1) The lease shall provide that... required by paragraph (c)(1) of this section apply only during the time the equipment is operated by or for...

  20. 49 CFR 376.12 - Written lease requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... forth in subpart C of this part, the written lease required under § 376.11(a) shall contain the... required by § 376.11(b). (c) Exclusive possession and responsibilities. (1) The lease shall provide that... required by paragraph (c)(1) of this section apply only during the time the equipment is operated by or for...

  1. First principles study on the elastic and electronic properties of CdX (X = S, Se and Te)

    NASA Astrophysics Data System (ADS)

    Sharma, Sheetal; Verma, Ajay Singh; Sarkar, Bimal Kumar; Bhandari, Rajiv; Jindal, Vijay Kumar

    2011-12-01

    Wide band gap semiconductors are emerging as a potential candidate for optically active materials in blue green spectral region and operating at high power level and high temperature. CdX, X = S, Se and Te are wide band gap semiconductors having applications in optoelectronics devices. In this paper we investigated the elastic and electronic properties of Cadmium chalcogenide (cubic zinc-blende (ZB) structure) using standard Kohn-Sham self consistent density functional theory method (DFT) that uses non conserving pseudopotentials in fully nonlocal form within the generalized gradient approximation (GGA) for the exchange-correlation potential. The independent elastic constants, C11, C12 and C44, are calculated from direct computation of stresses generated by small strains. The shear modulus and Young's modulus are estimated for CdX. Using the GGA for the exchange correlation potential, the calculated direct fundamental band gap value is in very good agreement with the measured one.

  2. Vibrational and elastic properties of silicate spinels A2SiO4 (A = Mg, Fe, Ni, and Co)

    NASA Astrophysics Data System (ADS)

    Kushwaha, A. K.; Ma, C.-G.; Brik, M. G.; Akbudak, S.

    2018-06-01

    A six-parameter bond-bending force constant model is used to calculate the zone-center (Γ = 0) Raman and infrared phonon mode frequencies, elastic constants and related properties, the Debye temperatures, and sound velocities along high-symmetry directions for A2SiO4 (A = Mg, Fe, Ni, and Co) spinels. The main outcomes of the calculations are that the interactions between Si and O atoms (first-neighbor interaction) are stronger than those between A and Oatoms (A = Mg, Fe, Ni, and Co) (second-neighbor interaction). The elastic constants C11, C12, and C44 decrease in the order Mg > Fe > Ni > Co. The calculated bulk modulus, Poisson's ratio, and anisotropy decrease in the sequence Fe2SiO4 → Ni2SiO4 → Co2SiO4 → Mg2SiO4. On comparison, we find overall good agreement with the available experimental and previously calculated data.

  3. Measurement characteristics of the childhood Asthma-Control Test and a shortened, child-only version

    PubMed Central

    Bime, Christian; Gerald, Joe K; Wei, Christine Y; Holbrook, Janet T; Teague, William G; Wise, Robert A; Gerald, Lynn B

    2016-01-01

    The childhood Asthma-Control Test (C-ACT) is validated for assessing asthma control in paediatric asthma. Among children aged 4–11 years, the C-ACT requires the simultaneous presence of both parent and child. There is an unmet need for a tool that can be used to assess asthma control in children when parents or caregivers are not present such as in the school setting. We assessed the psychometric properties and estimated the minimally important difference (MID) of the C-ACT and a modified version, comprising only the child responses (C-ACTc). Asthma patients aged 6–11 years (n=161) from a previously completed multicenter randomised trial were included. Demographic information, spirometry and questionnaire scores were obtained at baseline and during follow-up. Participants or their guardians kept a daily asthma diary. Internal consistency reliabilities of the C-ACT and C-ACTc were 0.76 and 0.67 (Cronbach’s α), respectively. Test–retest reliabilities of the C-ACT and C-ACTc were 0.72 and 0.66 (intra-class correlation), respectively. Significant correlations were noted between C-ACT scores and ACQ scores (Spearman’s correlation r=−0.56, 95% CI (−0.66, −0.44), P<0.001). The strength of the correlation between C-ACTc scores and ACQ scores was weaker (Spearman’s correlation r=−0.46, 95% CI (−0.58, −0.33), P<0.001). We estimated the MID for the C-ACT and C-ACTc to be 2 points and 1 point, respectively. Among asthma patients aged 6–11 years, the C-ACT had good psychometric properties. The psychometric properties of a shortened child-only version (C-ACTc), although acceptable, are not as strong. PMID:27763622

  4. Assessment of Enterotoxin Production and Cross-Contamination of Staphylococcus aureus between Food Processing Materials and Ready-To-Eat Cooked Fish Paste.

    PubMed

    Tango, Charles Nkufi; Hong, Sung-Sam; Wang, Jun; Oh, Deog-Hwan

    2015-12-01

    This study evaluated Staphylococcus aureus growth and subsequent staphylococcal enterotoxin A production in tryptone soy broth and on ready-to-eat cooked fish paste at 12 to 37 °C, as well as cross-contamination between stainless steel, polyethylene, and latex glove at room temperature. A model was developed using Barany and Roberts's growth model, which satisfactorily described the suitable growth of S. aureus with R(2)-adj from 0.94 to 0.99. Except at 12 °C, S. aureus cells in TSB presented a lag time lower (14.64 to 1.65 h), grew faster (0.08 to 0.31 log CFU/h) and produced SEA at lower cell density levels (5.65 to 6.44 log CFU/mL) compare to those inoculated on cooked fish paste with data of 16.920 to 1.985 h, 0.02 to 0.23 log CFU/h, and 6.19 to 7.11 log CFU/g, respectively. Staphylococcal enterotoxin type A (SEA) visual immunoassay test showed that primary SEA detection varied considerably among different storage temperature degrees and media. For example, it occurred only during exponential phase at 30 and 37 °C in TSB, but in cooked fish paste it took place at late exponential phase of S. aureus growth at 20 and 25 °C. The SEA detection test was negative on presence of S. aureus on cooked fish paste stored at 12 and 15 °C, although cell density reached level of 6.12 log CFU/g at 15 °C. Cross-contamination expressed as transfer rate of S. aureus from polyethylene surface to cooked fish paste surface was slower than that observed with steel surface to cooked fish paste under same conditions. These results provide helpful information for controlling S. aureus growth, SEA production and cross-contamination during processing of cooked fish paste. © 2015 Institute of Food Technologists®

  5. 12 CFR 1808.102 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... controlling influence, as determined by the CDFI Fund, over the management, credit decisions, investment... responsibilities regarding the management of the collateral, the management of the funds and accounts, the... such by the Office of Management and Budget pursuant to 44 U.S.C. 3504(e), 31 U.S.C. 1104(d) and...

  6. Secondary organic aerosol formation from propylene irradiations in a chamber study

    NASA Astrophysics Data System (ADS)

    Ge, Shuangshuang; Xu, Yongfu; Jia, Long

    2017-05-01

    Some studies have shown that low-molecular-weight VOCs such as ethylene and acetylene can form SOA. However, so far propylene (C3H6) has not been studied. The current work systematically investigates irradiations of propylene in the presence of NOx (x = 1, 2) in a self-made indoor chamber. Only a small amount of secondary organic aerosols (SOA) was formed under 5% and 80% RH conditions without sodium chloride (NaCl) seed particles or in the presence of solid NaCl. When NaCl was in the form of droplets, liquid water content (LWC) increased from 34.5 to 169.8 μg m-3 under different initial NaCl concentrations, and correspondingly the amount of SOA linearly increased from 5.9 to 29.8 μg m-3 (SOA = 0.0164 × LWC+1.137, R2 = 0.97) at the C3H6/NOx ratio of 32.2-44.9 (ppbC/ppb). The initial C3H6/NOx concentration ratio considerably impacted the formation of SOA, in which the amount of SOA increased from 12.1 to 47.9 μg m-3 exponentially as the ratio decreased from 46.5 to 6.3 with an important point of the ratio value of 11. At the ratio of less than 11 in the regime under the control of C3H6, SOA concentrations decreased considerably with increasing ratio, whereas at the ratio value of larger than 11 in the NOx controlled regime, SOA slightly decreased with increasing ratio. From combination of the analysis of different functional groups of particles by IR spectra and ESI-Exactive-Orbitrap mass spectrometer, the constituents of SOA were identified to be hydroperoxides (e.g. HOCH2CCl(CH3)OOH), esters (e.g. CH2ClC(O)OCHClCHO), organic nitrates (e.g. HO2CH(CH2Cl)C(O)OCCl(CH2Cl)C(O)OCHClCH2ONO2), etc. Furthermore, a liquid-phase mechanism of SOA formation has been proposed in this study.

  7. 32 CFR 256.6 - Runway classification by aircraft type.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Runway classification by aircraft type. 256.6... type. Class A runways S-2, VC-6, C-1, C-2, TC-4C, U-10, U-11, LU-16, TU-16, HU-16, C-7, C-8, C-12, C-47...-130, A-7, A-38, AV-8, P-2, P-3, T-29, T-33, T-37, T-39, T-1, HC-130B, C-131, C-140, C-5A, KC-97, F-9...

  8. 32 CFR 256.6 - Runway classification by aircraft type.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Runway classification by aircraft type. 256.6... type. Class A runways S-2, VC-6, C-1, C-2, TC-4C, U-10, U-11, LU-16, TU-16, HU-16, C-7, C-8, C-12, C-47...-130, A-7, A-38, AV-8, P-2, P-3, T-29, T-33, T-37, T-39, T-1, HC-130B, C-131, C-140, C-5A, KC-97, F-9...

  9. Evaluation of the effect of divalent metal transporter 1 gene polymorphism on blood iron, lead and cadmium levels

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kayaaltı, Zeliha, E-mail: kayaalti@ankara.edu.tr; Akyüzlü, Dilek Kaya; Söylemezoğlu, Tülin

    Divalent metal transporter 1 (DMT1), a member of the proton-coupled metal ion transporter family, mediates transport of ferrous iron from the lumen of the intestine into the enterocyte and export of iron from endocytic vesicles. It has an affinity not only for iron but also for other divalent cations including manganese, cobalt, nickel, cadmium, lead, copper, and zinc. DMT1 is encoded by the SLC11a2 gene that is located on chromosome 12q13 in humans and express four major mammalian isoforms (1A/+IRE, 1A/-IRE, 2/+IRE and 2/-IRE). Mutations or polymorphisms of DMT1 gene may have an impact on human health by disturbing metalmore » trafficking. To study the possible association of DMT1 gene with the blood levels of some divalent cations such as iron, lead and cadmium, a single nucleotide polymorphism (SNP) (IVS4+44C/A) in DMT1 gene was investigated in 486 unrelated and healthy individuals in a Turkish population by method of polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). The genotype frequencies were found as 49.8% homozygote typical (CC), 38.3% heterozygote (CA) and 11.9% homozygote atypical (AA). Metal levels were analyzed by dual atomic absorption spectrometer system and the average levels of iron, lead and cadmium in the blood samples were 446.01±81.87 ppm, 35.59±17.72 ppb and 1.25±0.87 ppb, respectively. Individuals with the CC genotype had higher blood iron, lead and cadmium levels than those with AA and CA genotypes. Highly statistically significant associations were detected between IVS4+44 C/A polymorphism in the DMT1 gene and iron and lead levels (p=0.001 and p=0.036, respectively), but no association was found with cadmium level (p=0.344). This study suggested that DMT1 IVS4+44 C/A polymorphism is associated with inter-individual variations in blood iron, lead and cadmium levels. - Highlights: • DMT1 IVS4+44 C/A polymorphism is associated with inter-individual variations in blood iron, cadmium and lead levels. • Individuals with the DMT1 IVS4+44 CC genotype had higher blood iron, lead and cadmium levels. • Individuals with DMT1 IVS4+44 CC genotype may be more susceptible for metal toxicity.« less

  10. Integrated Computer-Aided Manufacturing (ICAM) Architecture. Part 3. Volume 7. MFG01 Glossary.

    DTIC Science & Technology

    1983-09-01

    lat oe C % 000 Sj C4 le ’ 4, 4,4 2:4 tj t*K l- X: 44 0’~ k IW- C4 % 40 Go r 00 c ~ IL P v C c -. . v IL zl - 4 1 S . v I .I a w I 1 v c u > c- -FT U 4...CC c .C C aI o , 0 A Z . 6--c 0 cCrV 46 a .0 b. 1 c 1 . Ga, v 0 M 0 44 c c c f-V - 4 0 aLS C C - . l-l - 2 - 0 S- C (~ b , J O’~ 0 .4. hSV b... ~ b...RD-R144 426 INTEGRATED COMPUTER-AIDED MANUFACTURING (ICAM)_ 1 /3 ARCHITECTURE PART 3 VOLUME.. (U) SOFTECH INC WALTHAM MRR HEINE ET RL. SEP 83 RFWRL-TR

  11. Proton Distribution Radii of 12-19C Illuminate Features of Neutron Halos

    DOE PAGES

    Kanungo, R.; Horiuchi, W.; Hagen, Gaute; ...

    2016-09-02

    We report proton radii of 12-19C densities derived from first accurate charge changing cross section measurements at 900A MeV with a carbon target. A thick neutron surface evolves from ~0.5 fm in 15C to ~1 fm in 19C. Also, the halo radius in 19C is found to be 6.4±0.7 fm as large as 11Li. Ab initio calculations based on chiral nucleon-nucleon and three-nucleon forces reproduce the radii well.

  12. 44 CFR 63.12 - Setback and community flood plain management requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.12... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Setback and community flood...

  13. 44 CFR 63.12 - Setback and community flood plain management requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.12... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Setback and community flood...

  14. 44 CFR 63.12 - Setback and community flood plain management requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.12... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Setback and community flood...

  15. 44 CFR 63.12 - Setback and community flood plain management requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.12... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Setback and community flood...

  16. 44 CFR 63.12 - Setback and community flood plain management requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.12... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Setback and community flood...

  17. Occurrence of Cronobacter spp. in Dried Foods, Fresh Vegetables and Soil.

    PubMed

    Ueda, Shigeko

    2017-01-01

    　The present study surveyed the occurrence of Cronobacter spp. in dried foods including milk powder, spices and herbs and others, and fresh vegetables commercially available in markets, and ground soil materials for the agriculture. Cronobacter spp. were isolated from 15% of 33 spice and herb samples and 3% of 36 taste foods, and these were C. turicensis, C. malonaticus, C. sakazakii and C. dubliensis. Cronobacter spp. from fresh vegetables were detected in 12% of field vegetables and 13% of hydroponic vegetables. C. turicensis was prevalent in field vegetables, and C. malonaticus was in hydroponic ones. And, Cronobacter spp. in shredded vegetables were detected from 44% of 9 samples, and these were C. dubliensis, C. turicensis and C. sakazakii. Also, Cronobacter spp. in soil from rice field, vegetable field and sandpits were predominantly C. sakazakii and C. malonaticus.

  18. Data Presentation Report, Army Spill Sites, South Plants Manufacturing Complex. Version 3.2. Phase I

    DTIC Science & Technology

    1988-09-01

    M d C ’, pC c0 a, on 4. 10 C *0 o * ... 44 4. 14. 0 4 A. 0 tfl Vf M m Al 4, 1 Vam 77ey cS b. C tM 0 ’a .4 1 c 0 *ý 0 n 3* z aE~ c - aa42a 6%-E. a m...0 do I0 aa lp 4A - S CE 00 .1 .2.. .1.2 in .3 .2 .3 V)L 10. a MCA 6* . 6 6 mm 41 41 a 0 0 In 0 .0 4 a to0 ,C v I0 IP EEG %C.3 .3.3 .3.2 . C~~~- on 00...CLC2AThiodiglycol Thiodiglycol ( TDC ) TDGCL jAGET PRIO CHRQ D= Isopropylmethylphosphonic Isopropylmethylphosphonate IMPA acid ANIONS /IONCHROM Chloride Chloride CL

  19. Degradation and mineralization of DDT by the ectomycorrhizal fungi, Xerocomus chrysenteron.

    PubMed

    Huang, Yi; Wang, Jie

    2013-08-01

    One strain of ectomycorrhizal fungi, Xerocomus chrysenteron, had been investigated for its ability to degrade 1,1,1-trichloro-2,2-bis(4-chlorophe-nyl) ethane (DDT) by measuring unlabeled DDT and identifying its metabolites, and determining the mineralization of [(13)C]DDT in pure cultures. After 45d incubation, about 55% of the added DDT disappeared from the culture system, less than 5% remained in the nutrient solution, and about 44% was retained in the mycelium. Inoculation with mycelium enhanced the degradation of DDT in soil, and alleviated enrichment of DDT in plants. The metabolites identified by gas chromatography-mass spectrometry were 1,1-dichloro-2,2-bis(4-chlorophenyl) ethane (DDD), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE), and 4,4'-dichlorobenzophenone (DBP). There were significant differences in the δ(13)C of released CO2 between [(13)C]DDT and DDT cultures, which indicated X. chrysenteron was able to mineralize DDT to CO2. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Utica New York - Copan Oklahoma)

    DTIC Science & Technology

    1993-01-01

    0 0 NISNN ISUSI0001 i 4 4 4 4 4 . is 000i z2 L 4 ZZZ2zzzzzzz 00 2 000V is -S -4 00=- 55 N4 N 4.N -4 .-4 N * LaJ 00( 11 N Z 2-6 zN ZN.. Z 4 ZN Z...qN0 is 0) .-. M0 in P- 4P 55 -44- 1-O-0( P, P- r, 11r-w-f’- * N-4 0- NO4" is q oo I-. 1-. -4 -4 4,4 14w- N -4 Go c000 N 41 I C-SO is 0 0 0 0 40...00000000000000 00 M00000000000000 M M M -4"<J05 M0- (400 55 ,ZNNZCZZCZZZZZZZZ’Z4C’JZZZZZZZZ NZZZZZZ𔃾 .1CC 01[0-TMM -Nf . 0 0-4w(to4 55 LALA L AOLOLO00

  1. μ(3)-Carbonato-κO:O':O''-tris-{(η-ben-zene)[(R)-1-(1-amino-ethyl)naphthyl-κC,N]ruthenium(II)} hexa-fluorido-phosphate dichloro-methane solvate.

    PubMed

    Sortais, Jean-Baptiste; Brelot, Lydia; Pfeffer, Michel; Barloy, Laurent

    2008-02-15

    The title compound, [Ru(3)(C(12)H(12)N)(3)(CO(3))(C(6)H(6))(3)]PF(6)·CH(2)Cl(2), was obtained unintentionally as the product of an attempted deprotonation of the monomeric parent ruthenium complex [Ru(C(12)H(12)N)(C(6)H(6))(C(2)H(3)N)]PF(6). The carbonate ligand bridges three half-sandwich cyclo-ruthenated fragments, each of them exhibiting a pseudo-tetra-hedral geometry. The configuration of the Ru atoms is S. The naphthyl groups of the enanti-opure cyclo-ruthenated benzylic amine ligands point in the same direction, adopting a propeller shape.

  2. "NR3C1" Methylation as a Moderator of the Effects of Maternal Support and Stress on Insecure Attachment Development

    ERIC Educational Resources Information Center

    Bosmans, Guy; Young, Jami F.; Hankin, Benjamin L.

    2018-01-01

    We examined the prediction that the interaction between Glucocorticoid Receptor Gene ("NR3C1") methylation, stress, and experienced maternal support predicts anxious and avoidant attachment development. This was tested in a general population sample of 487 children and adolescents (44% boys, M[subscript age] = 11.84, SD[subscript age] =…

  3. Interaction of hydrated electron with dietary flavonoids and phenolic acids: rate constants and transient spectra studied by pulse radiolysis.

    PubMed

    Cai, Z; Li, X; Katsumura, Y

    1999-10-01

    The reaction rate constants and transient spectra of 11 flavonoids and 4 phenolic acids reacting with e(aq)- at neutral pH were measured. Absorption bands of the transients of e(aq)- reacting with the above compounds all located at a wavelength shorter than 400 nm. The e(aq)- scavenging abilities were divided into three groups: (+)catechin ((1.2 +/-0.1) x 10(8) M(-1)s(-1)) < 4-chromanol ((4.4 +/- 0.4) x 10(8) M(-1)s(-1)) < genistein ((6.2+/-0.4) x 10(9) M (-1) s(-1) approximately genistin ((8 +/- 1) x 10(9) M(-1)s(-1)) approximately rutin ((7.6 +/- 0.4) x M(-1)s(-1) approximately caffeic acid ((8.3 +/- 0.5) x 10(9)M(-1)s(-1)) < transcinnamic acid((1.1 +/- 0.1) x 10(10) M(-1)s(-1)) approximately p-coumaric acid ((1.1 +/- 0.1) x 10(10) M(-1)s(-1) approximately 2,4,6-trihydroxylbenzoic acid((1.1 +/- 0.1) x 10(10) M(-1)s(-1)) approximately baicalein ((1.1 +/- 0.5) x 10(10) M(-1)s(-1)) approximately baicalin((1.3 + 0.1) X 10(10) M(-1)s(-1)) approximately naringenin ((1.2 +/- 0.1) x 10(10) M(-1)s(-1)) approximately naringin ((1.0 +/- 0.1) x 10(10) M(-1)s(-1)) approximately gossypin((1.2 +/- 0.1) x 10(10) M(-1)s(-1)) approximately quercetin((1.3 +/- 0.5) x 10(10) M(-1)s(-1)). These results suggested that C4 keto group is the active site for e(aq)- to attack on flavonoids and phenolic acids, whereas the o-dihydroxy structure in B ring, the C2,3 double bond, the C3-OH group, and glucosylation, which are key structures that influence the antioxidant activities of flavonoids and phenolic acids, have little effects on the e(aq)- scavenging activities.

  4. Development of Graphical Pole-Zero, Root-Locus, Bode, Nyquist, and Nichols Responses Using the OPTSYSX Program.

    DTIC Science & Technology

    1984-09-01

    JV) 0..J- 11- 0.7 it HIZ-z7WaWI 1-I 1 1- I"c 9-4... It-)% -Q-0 .) 15 1 ’-0 -a -aI w Lo I U .. J()V) .40%. 11 UL)(S)Cg’ 11 VOZ - - ’-0 1 ’-I U). 0...34- 9-4W s-XW-XJ) 11 W 04- 11 .J I LVLOL- G*Z- 1 1" I -SI . . . . . .4 1 11I ZNJ’-..i9-- XI-%WtDo N DLD1-slC T 0 z(~zt)->I I V-1 PIŕ IP OH Zj .-I- 0...ut) WWCD U󈧎-,-o,- 0 L,4-u4,44u4-- ut 1 i I4j<=wa: a.) m- ip -, wnJ 11111> .60o .0 - 1 Wl -to -W l .J11 lii 11 1111 Z"’")i 1~~:...cIV..L UIZIn-’Z F

  5. Search for multipolar instability in URu2Si2 studied by ultrasonic measurements under pulsed magnetic field

    NASA Astrophysics Data System (ADS)

    Yanagisawa, T.; Mombetsu, S.; Hidaka, H.; Amitsuka, H.; Cong, P. T.; Yasin, S.; Zherlitsyn, S.; Wosnitza, J.; Huang, K.; Kanchanavatee, N.; Janoschek, M.; Maple, M. B.; Aoki, D.

    2018-04-01

    The elastic properties of URu2Si2 in the high magnetic field region above 40 T, over a wide temperature range from 1.5 to 120 K, were systematically investigated by means of high-frequency ultrasonic measurements. The investigation was performed at high magnetic fields to better investigate the innate bare 5 f -electron properties, since the unidentified electronic thermodynamic phase of unknown origin, the so-called "hidden order" (HO), and associated hybridization of conduction and f electrons (c -f hybridization) are suppressed at high magnetic fields. From the three different transverse modes we find contrasting results; both the Γ4(B2 g) and Γ5(Eg) symmetry modes C66 and C44 show elastic softening that is enhanced above 30 T, while the characteristic softening of the Γ3(B1 g) symmetry mode (C11-C12)/2 is suppressed in high magnetic fields. These results underscore the presence of a hybridization-driven Γ3(B1 g) lattice instability in URu2Si2 . However, the results from this work cannot be explained by using existing crystalline electric field schemes applied to the quadrupolar susceptibility in a local 5 f2 configuration. Instead, we present an analysis based on a band Jahn-Teller effect.

  6. Aircraft Configuration Noise Reduction. Volume 3. Computer Program Source Listing

    DTIC Science & Technology

    1976-06-01

    CAT GEN 11 12=1 1+11 CATGtN 32 0360 REAOIKI,10CENIj=4C)(OT(J),.I=11,I2) CATCEN 33 REAO(KI, 100) fDI (JbJ=I#Ii) CATGtkN 34 IF (EOF(KI)) 4C9 20 CATGEN...CORE ANu IURBINE CGNVk 1 COMMON/COREIN/T13,PP3,cMF3,EX3,oELT3,J83, CONVR 13 CONVR 1’ C =5 EXIT FANC .,NVx i COMMUN/FANUAT/NSIG45,NLET45,NAFT45,1CP45,N845

  7. Medical nutrition therapy administered by a dietitian yields favourable diabetes outcomes in individual with type 2 diabetes mellitus.

    PubMed

    Barakatun Nisak, M Y; Ruzita, A T; Norimah, A K; Kamaruddin, N A

    2013-01-01

    This prospective, single-group, pre-post design trial was conducted to evaluate the effect of individualised Medical Nutrition Therapy intervention administered by a dietitian in individuals with type 2 diabetes mellitus on glycaemic control, metabolic parameters and dietary intake. Subjects (n=104; age=56.4 ±9.9 years; 37% male; years of diagnosis = 6.3 ±4.9 years) treated with diet and on a stabile dose of oral anti-diabetic agents were given dietary advice by a dietitian for a 12 week period. Individualised dietary advice was based on Malaysian Medical Nutrition Therapy for adults with type 2 diabetes mellitus. The primary outcome measure was glycaemic control (fructosamine and HbA1c level) and the secondary outcome included measures of anthropometry, blood pressure, lipid profile, insulin levels dietary intake and knowledge on nutrition. At week 12, 100 subjects completed the study with a dropout rate of 3.8%. The post-Medical Nutrition Therapy results showed a significant reduction of fructosamine (311.5 ±50 to 297 ±44 umol/L; P< 0.001) and HbA1c (7.6 ±1.2 to 7.2 +1.1%, p<0.001) with pronounced reduction for subjects who had very high HbA1c levels of >9.3% at baseline. Waist circumference (90.7 ±10.2 to 89.1 ±9.8 cm, p<0.05), HDL-cholesterol (1.1 ±0.3 to 1.2 ±0.3 mmol/L, p<0.05), dietary intake and nutrition knowledge score (42 ±19 vs. 75 ±17%; p< 0.001) were significantly improved from the baseline. Individualised Medical Nutrition Therapy administered by a dietitian resulted in favourable diabetes outcomes, which were more apparent for individuals with higher than optimal HbA1c levels at the start of the study.

  8. Late-Glacial to Early Holocene Climate Changes from a Central Appalachians Pollen and Macrofossil Record

    NASA Technical Reports Server (NTRS)

    Kneller, Margaret; Peteet, Dorothy

    1997-01-01

    A Late-glacial to early Holocene record of pollen, plant macrofossils and charcoal, based on two cores, is presented for Browns Pond in the central Appalachians of Virginia. An AMS radiocarbon chronology defines the timing of moist and cold excursions, superimposed upon the overall warming trend from 14,200 to 7,500 C-14 yr B.P. This site shows cold, moist conditions from approximately 14,200 to 12,700 C-14 yr B.P., with warming at 12,730, 11,280 and 10,050 C-14 yr B.P. A decrease in deciduous broad-leaved tree taxa and Pinus strobus (haploxylon) pollen, simultaneous with a re-expansion of Abies denotes a brief, cold reversal from 12,260 to 12,200 C-14 yr B.P. A second cold reversal, inferred from increases in montane conifers, is centered at 7,500 C-14 yr B.P. The cold reversals at Browns Pond may be synchronous with climate change in Greenland, and northwestern Europe. Warming at 11,280 C-14 yr B.P. shows the complexity of regional climate responses during the Younger Dryas chronozone.

  9. Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?

    PubMed

    Tanyıldız, Hikmet Gülşah; Yeşil, Şule; Bozkurt, Ceyhun; Çandır, Mehmet Onur; Akpınar-Tekgündüz, Sibel; Toprak, Şule; Yüksel, Deniz; Şahin, Gürses

    2016-01-01

    The methylenetetrahydrofolate reductase (MTHFR) gene plays a key role in carcinogenesis through its effects on DNA synthesis and methylation and also has a significant role in the etiology of many disorders, such as diabetes, migraine, and cardiovascular disease. Neurofibromatoses (NF) are autosomal dominant inherited diseases that can affect tissues such as bone and skin and predispose individuals to tumor development in various parts of the nervous system or body. Optic nerve glioma and brain tumors are common in children with NF, and leukemia and lymphoma incidence is also higher than normal. We therefore aimed to investigate the possible relationship between the MTHFR gene polymorphism and accompanying tumors such as neurofibroma, hamartoma, and optic glioma in children with NF1 found to have the MTHFR 677 and MTHFR 1298 gene polymorphism in this study. We included 55 pediatric patients diagnosed with NF1 between 2005 and 2014 in the study group. The control group included 44 healthy subjects without acute or chronic disease findings. A significant relationship was found between the MTHFR A1298C polymorphism and the incidence of optic glioma (p=0.014) (AA vs. AC: OR 11, 95% CI 1.27-95.17; AA vs. CC: OR 7.33, 95% CI 0.35-150.70). We also found a significant relationship between the MTHFR C1298C polymorphism and the incidence of hamartoma (p=0.019) (AA vs. AC: OR 2.12, 95% CI 0.662-6.809; p=0.203). Epilepsy incidence was high in subjects with MTHFR C677C. The MTHFR A1298C, C1298C, and C677C gene polymorphisms can be associated with a higher optic glioma, hamartoma, and epilepsy incidence, respectively, in patients diagnosed with neurofibromatosis type 1.

  10. Magnetostratigraphy in the Lodo Formation, CA: An Attempt to Locate Hyperthermals of the Early Eocene

    NASA Astrophysics Data System (ADS)

    Aldrich, N. C.; Pluhar, C. J.; Gibbs, S.; Rieth, J. A.

    2015-12-01

    The Lodo Formation in the California Coast Range, Fresno County records the Paleocene Eocene Thermal Maximum (PETM) and possibly other Early Eocene hyperthermal events. The Eocene Thermal Maximum 2 (ETM2, ELMO, or H1) represents a hyperthermal event that occurred approximately 2 million years after the PETM and just prior to the C24r - C24n magnetic reversal (≈ 53.9 Ma) in the Ypresian. While the ETM2 event has been located in offshore samples, it has been more difficult to locate in a terrestrial section. This project attempts to locate the ETM2 magnetostratigraphically by finding the paleomagnetic reversal at C24r-C24n.3n, provide geochronological framework, and assess sedimentation rate changes during this time. This area is known to have had a high rate of deposition (16.8 cm/kyr ) during the PETM, which is found lower in the section. We collected 36 new samples from a 13.44m section spanning stratigraphy thought to cover the ETM2 along with 31 previous samples spanning the PETM, and prepared them for paleomagnetic and paleontological analysis. We analyzed samples using standard paleomagnetic methods including low-temperature and thermal demagnetization. Preliminary results suggest that the magnetostratigraphy spans the C24r-C24n boundary, while the micropaleontology shows the NP10-NP11 boundary, which occurs near the ETM2 as well as the NP11-NP12 boundary. The data indicate an order-of-magnitude drop in sedimentation rate in the lower Eocene at this site, concomitant with a drop in grain size, compared with the PETM.

  11. Wormlike micelle formation by acylglutamic acid with alkylamines.

    PubMed

    Sakai, Kenichi; Nomura, Kazuyuki; Shrestha, Rekha Goswami; Endo, Takeshi; Sakamoto, Kazutami; Sakai, Hideki; Abe, Masahiko

    2012-12-21

    Rheological properties of alkyl dicarboxylic acid-alkylamine complex systems have been characterized. The complex materials employed in this study consist of an amino acid-based surfactant (dodecanoylglutamic acid, C12Glu) and a tertiary alkylamine (dodecyldimethylamine, C12DMA) or a secondary alkylamine (dodecylmethylamine, C12MA). (1)H NMR and mass spectroscopic data have suggested that C12Glu forms a stoichiometric 1:1 complex with C12DMA and C12MA. Rheological measurements have suggested that the complex systems yield viscoelastic wormlike micellar solutions and the rheological behavior is strongly dependent on the aqueous solution pH. This pH-dependent behavior results from the structural transformation of the wormlike micelles to occur in the narrow pH range 5.5-6.2 (in the case of C12Glu-C12DMA system); i.e., positive curved aggregates such as spherical or rodlike micelles tend to be formed at high pH values. Our current study offers a unique way to obtain viscoelastic wormlike micellar solutions by means of alkyl dicarboxylic acid-alkylamine complex as gemini-like amphiphiles.

  12. Direct Test for Neuroinflammation with [11C]DAP-713-PET Scanning

    DTIC Science & Technology

    2015-10-01

    individuals suffering from the Gulf War Illness (GWI). We are using quantitative positron emission tomography (PET) using [11C]DPA-713 (DPA). DPA...suffering from the Gulf War Illness (GWI). We are using quantitative positron emission tomography (PET) using [11C]DPA-713 (DPA). DPA binds to the... Resistant Prostate Cancer Time commitments: 0.12 calendar months Supporting Agency: CDMRP Grants Contact: TBD PI: Denmeade Co-Investigator

  13. 12C/13C isotopic ratios in red-giant stars of the open cluster NGC 6791

    NASA Astrophysics Data System (ADS)

    Szigeti, László; Mészáros, Szabolcs; Smith, Verne V.; Cunha, Katia; Lagarde, Nadège; Charbonnel, Corinne; García-Hernández, D. A.; Shetrone, Matthew; Pinsonneault, Marc; Allende Prieto, Carlos; Fernández-Trincado, J. G.; Kovács, József; Villanova, Sandro

    2018-03-01

    Carbon isotope ratios, along with carbon and nitrogen abundances, are derived in a sample of 11 red-giant members of one of the most metal-rich clusters in the Milky Way, NGC 6791. The selected red-giants have a mean metallicity and standard deviation of [Fe/H] = +0.39 ± 0.06 (Cunha et al. 2015). We used high-resolution H-band spectra obtained by the SDSS-IV Apache Point Observatory Galactic Evolution Experiment. The advantage of using high-resolution spectra in the H band is that lines of CO are well represented and their line profiles are sensitive to the variation of 12C/13C. Values of the 12C/13C ratio were obtained from a spectrum synthesis analysis. The derived 12C/13C ratios varied between 6.3 and 10.6 in NGC 6791, in agreement with the final isotopic ratios from thermohaline-induced mixing models. The ratios derived here are combined with those obtained for more metal poor red-giants from the literature to examine the correlation between 12C/13C, mass, metallicity, and evolutionary status.

  14. Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins

    PubMed Central

    de Val, Natalia; McMurray, Michael A.; Lam, Lisa H.; Hsiung, Chris C.-S.; Bertin, Aurélie; Nogales, Eva; Thorner, Jeremy

    2013-01-01

    Budding yeast septins assemble into hetero-octamers and filaments required for cytokinesis. Solvent-exposed cysteine (Cys) residues provide sites for attaching substituents useful in assessing assembly kinetics and protein interactions. To introduce Cys at defined locations, site-directed mutagenesis was used, first, to replace the native Cys residues in Cdc3 (C124 C253 C279), Cdc10 (C266), Cdc11 (C43 C137 C138), Cdc12 (C40 C278), and Shs1 (C29 C148) with Ala, Ser, Val, or Phe. When plasmid-expressed, each Cys-less septin mutant rescued the cytokinesis defects caused by absence of the corresponding chromosomal gene. When integrated and expressed from its endogenous promoter, the same mutants were fully functional, except Cys-less Cdc12 mutants (which were viable, but exhibited slow growth and aberrant morphology) and Cdc3(C124V C253V C279V) (which was inviable). No adverse phenotypes were observed when certain pairs of Cys-less septins were co-expressed as the sole source of these proteins. Cells grew less well when three Cys-less septins were co-expressed, suggesting some reduction in fitness. Nonetheless, cells chromosomally expressing Cys-less Cdc10, Cdc11, and Cdc12, and expressing Cys-less Cdc3 from a plasmid, grew well at 30ºC. Moreover, recombinant Cys-less septins—or where one of the Cys-less septins contained a single Cys introduced at a new site—displayed assembly properties in vitro indistinguishable from wild-type. PMID:23775754

  15. 26 CFR 1.597-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... means the Resolution Trust Corporation, the Federal Deposit Insurance Corporation, any similar... chartered by the Comptroller of the Currency under section 11(n) of the Federal Deposit Insurance Act (12 U... Federal Home Loan Bank Act (12 U.S.C. 1441a(b)(4)), section 11(f) or 13(c) of the Federal Deposit...

  16. 12 CFR 567.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...)(2) and 567.8 with tier 1 capital, as computed under sections 11 and 12 of Appendix C of this part... applies to all savings associations, except as described in paragraph (b) of this section. (b)(1) A... § 567.11, which supplement the reservations of authority at section 1 of Appendix C of this part. [72 FR...

  17. Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991

    DTIC Science & Technology

    1991-01-01

    u I (04q N -iLifLn-i0)00 .- Cl) -- If .’t- -- 400 r1I- -4-. M(𔄁 . "I XN 1,- 1I to I (04e 11 1f4.-400𔃾 in -f o~n InJ N L0304 toN 0n (no U O 4 vUN 0...o CN M C) a) "൒ -’ 14"to0" C>(W P 00(W0t- 00m 0- --4 C~nC’ r-- KooN 400 0 -4-4 a0(D0)( w 4(1(0 -4 * 4m( 0-4 m0000000CC>C0 -4"K 4OI 41 CC D>)- 000C

  18. Determination of the equation parameters of carbon flow curves and estimated carbon flow and CO2 emissions from broiler production.

    PubMed

    Henn, J D; Bockor, L; Borille, R; Coldebella, A; Ribeiro, A M L; Kessler, A M

    2015-09-01

    The objective of this study was to determine the equation parameters of carbon (i.e., C) flow curves and to estimate C flow and carbon dioxide (i.e., CO2) emissions from the production of 1- to 49-day-old broilers from different genetic strains. In total, 384 1-day-old chicks were used, distributed into 4 groups: high-performance males (Cobb-M) and females (Cobb-F), and intermediate-performance males (C44-M) and females (C44-F), with 6 replicates/treatment according to a completely randomized study design. Carbon intake and retention were calculated based on diet and body C composition, and expired C was stoichiometrically estimated as digestible C intake-C retention-C in the urine. Litter C emission was estimated as initial litter C+C in the excreta-final litter C. Carbon flow curves were determined fitting data by nonlinear regression using the Gompertz function. Expired CO2 was calculated based on expired C. The applied nonlinear model presented goodness-of-fit for all responses (R2>0.99). Carbon dioxide production was highly correlated with growth rate. At 42 d age, CO2 expiration (g/bird) was 3,384.4 for Cobb-M, 2,947.9 for Cobb-F, 2,512.5 for C44-M, and 2185.1 for C44-F. Age also significantly affected CO2 production: to achieve 2.0 kg BW, CO2 expiration (g/bird) was 1,794.3 for Cobb-M, 2,016.5 for Cobb-F, 2617.7 for C44-M, and 3,092.3 for C44-F. The obtained equations present high predictability to estimate individual CO2 emissions in strains of Cobb and C44 broilers of any weight, or age, reared between 1 and 49 d age. © 2015 Poultry Science Association Inc.

  19. Hot bats: extreme thermal tolerance in a desert heat wave.

    PubMed

    Bondarenco, Artiom; Körtner, Gerhard; Geiser, Fritz

    2014-08-01

    Climate change is predicted to increase temperature extremes and thus thermal stress on organisms. Animals living in hot deserts are already exposed to high ambient temperatures (T a) making them especially vulnerable to further warming. However, little is known about the effect of extreme heat events on small desert mammals, especially tree-roosting microbats that are not strongly protected from environmental temperature fluctuations. During a heat wave with record T as at Sturt National Park, we quantified the thermal physiology and behaviour of a single free-ranging little broad-nosed (Scotorepens greyii, henceforth Scotorepens) and two inland freetail bats (Mormopterus species 3, henceforth Mormopterus) using temperature telemetry over 3 days. On 11 and 13 January, maximum T a was ∼45.0 °C, and all monitored bats were thermoconforming. On 12 January 2013, when T a exceeded 48.0 °C, Scotorepens abandoned its poorly insulated roost during the daytime, whereas both Mormopterus remained in their better insulated roosts and were mostly thermoconforming. Maximum skin temperatures (T skin) ranged from 44.0 to 44.3 °C in Scotorepens and from 40.0 to 45.8 °C in Mormopterus, and these are the highest T skin values reported for any free-ranging bat. Our study provides the first evidence of extensive heat tolerance in free-ranging desert microbats. It shows that these bats can tolerate the most extreme T skin range known for mammals (3.3 to 45.8 °C) and delay regulation of T skin by thermoconforming over a wide temperature range and thus decrease the risks of dehydration and consequently death.

  20. Time Domain Aperture Antenna Study. Volume 1

    DTIC Science & Technology

    1974-10-01

    IS. KF.Y WORDS (Vo, wo em e•,.’*I aIdv ft # .ce.-y ws4 tdanti, &Ow W•Ai nw* Ab ) Antennas Tranalent Aperture Radiation t.•’t. hiNATIONAL TECHNICAL...aL3 Cora 4 la V%") AA C05 (11c) Substituting Eq. (11) into (8), and using Eq. (5) gives - Ab . c ~ ve Gv (12A) (12B The bracketed terms in Eq. (12) may...experimental data on an ab :;olute basis in thi.; report. S57 - CHAPTER 3 TRANSIENT RADIATION FROM A PARABOLOID 3.1 INTRODUC T ION This chapter is intended to

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