Characterization of Current Tower Cab Environments

DOT National Transportation Integrated Search

1977-11-01

This report describes the general tower cab environment in terms of: (a) the evolution of the tower cab, current cab classification and staffing levels, and the basic flow of ATC data relevant to cab operations, (b) a breakdown of functions performed...

Finite element analysis of ROPS for mechanical driving dump truck cab

NASA Astrophysics Data System (ADS)

Wang, Yong; Xie, Heping; Fang, Yuanbin; Feng, Handui; Dong, Lei

2018-02-01

For roll-over protective structures (ROPS) in a mechanical driving dump truck cab, it simulates the lateral, vertical and longitudinal loads of ROPS. It obtains stress and deformation of the cab that occurs to roll. For the relative weak position of ROPS in the cab, the structure of the cab is improved and verified according to the ISO 3164: 1995. The results show that the established finite element model can effectively predict the deformation and stress distribution of ROPS, and optimize the weak structure of the cab, which has important guiding significance for structural design of the cab and ROPS optimization of the mechanical driving dump truck cab.

Investigation of nonlinear motion simulator washout schemes

NASA Technical Reports Server (NTRS)

Riedel, S. A.; Hofmann, L. G.

1978-01-01

An overview is presented of some of the promising washout schemes which have been devised. The four schemes presented fall into two basic configurations; crossfeed and crossproduct. Various nonlinear modifications further differentiate the four schemes. One nonlinear scheme is discussed in detail. This washout scheme takes advantage of subliminal motions to speed up simulator cab centering. It exploits so-called perceptual indifference thresholds to center the simulator cab at a faster rate whenever the input to the simulator is below the perceptual indifference level. The effect is to reduce the angular and translational simulation motion by comparison with that for the linear washout case. Finally, the conclusions and implications for further research in the area of nonlinear washout filters are presented.

Role of extracellular matrix protein CabA in resistance of Vibrio vulnificus biofilms to decontamination strategies.

PubMed

Park, Jin Hwan; Lee, Byungho; Jo, Youmi; Choi, Sang Ho

2016-11-07

Biofilms are recalcitrant and raise safety problems in the food industry. In this study, the role of CabA, an extracellular matrix protein, in the resistance of the biofilms of Vibrio vulnificus, a foodborne pathogen, to decontamination strategies was investigated. Biofilms of the cabA mutant revealed reduced resistance to detachment by vibration and disinfection by sodium hypochlorite compared to the biofilms of the parental wild type in vitro. The reduced resistance of the cabA mutant biofilms was complemented by introducing a recombinant cabA, indicating that the reduced resistance of the cabA mutant biofilms is caused by the inactivation of cabA. The expression of cabA was induced in cells bound to oyster, the primary vehicle of the pathogen. The cabA mutant biofilms on oyster are defective in biomass and resistance to detachment and disinfection. The bacterial cells in the wild-type biofilms are clustered by filaments which are not apparent in the cabA mutant biofilms. The combined results indicated that CabA contributes to the structural integrity of V. vulnificus biofilms possibly by forming filaments in the matrix and thus rendering the biofilms robust, suggesting that CabA could be a target to control V. vulnificus biofilms on oyster. Copyright © 2016 Elsevier B.V. All rights reserved.

49 CFR 236.515 - Visibility of cab signals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Visibility of cab signals. 236.515 Section 236.515..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.515 Visibility of cab signals. The cab signals...

49 CFR 236.515 - Visibility of cab signals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Visibility of cab signals. 236.515 Section 236.515..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.515 Visibility of cab signals. The cab signals...

49 CFR 236.515 - Visibility of cab signals.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Visibility of cab signals. 236.515 Section 236.515..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.515 Visibility of cab signals. The cab signals...

49 CFR 236.515 - Visibility of cab signals.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Visibility of cab signals. 236.515 Section 236.515..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.515 Visibility of cab signals. The cab signals...

49 CFR 236.515 - Visibility of cab signals.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Visibility of cab signals. 236.515 Section 236.515..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.515 Visibility of cab signals. The cab signals...

49 CFR 230.87 - Cab lights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Cab lights. 230.87 Section 230.87 Transportation... Signals, Sanders and Lights § 230.87 Cab lights. Each steam locomotive shall have cab lights that... readings from their usual and proper positions in the cab. These lights shall be so located and constructed...

49 CFR 230.87 - Cab lights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Cab lights. 230.87 Section 230.87 Transportation... Signals, Sanders and Lights § 230.87 Cab lights. Each steam locomotive shall have cab lights that... readings from their usual and proper positions in the cab. These lights shall be so located and constructed...

49 CFR 230.87 - Cab lights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Cab lights. 230.87 Section 230.87 Transportation... Signals, Sanders and Lights § 230.87 Cab lights. Each steam locomotive shall have cab lights that... readings from their usual and proper positions in the cab. These lights shall be so located and constructed...

49 CFR 230.87 - Cab lights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Cab lights. 230.87 Section 230.87 Transportation... Signals, Sanders and Lights § 230.87 Cab lights. Each steam locomotive shall have cab lights that... readings from their usual and proper positions in the cab. These lights shall be so located and constructed...

49 CFR 230.87 - Cab lights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Cab lights. 230.87 Section 230.87 Transportation... Signals, Sanders and Lights § 230.87 Cab lights. Each steam locomotive shall have cab lights that... readings from their usual and proper positions in the cab. These lights shall be so located and constructed...

Operators' perception of comfort in two tractor cabs.

PubMed

Ferrari, E; Cavallo, E

2013-01-01

Workspace characteristics affect the perceived comfort level of the operator and uncomfortable working conditions have been found to have a negative impact on productivity and safety. The comfort of the operator is increasingly recognized by manufacturers as a product's added value. Comfort can positively distinguish a product and increase its competitiveness. The concept of comfort is controversial, and a clear operational definition is missing. Nevertheless, it is widely accepted that comfort is a subjective phenomenon that can be evaluated by the final users. In this study, comfort aspects of the tractor workspace interior (i.e., the cab) were investigated. Users with various levels of expertise and two medium-power utility tractors of different brands were used in a 2 x 2 mixed-factorial experimental design. Participants were involved in a dynamic assessment of the cabs, and their opinions about the different workspaces were collected through a questionnaire. Additionally, objective measurements were taken on both tractors, and subjective data were compared with objective data. Results indicate significant differences in terms of the ease of locating and operating the controls (i.e., rear-mounted three-point linkage, hydraulic system, and power take-off), the ease of starting the tractor, the ease exiting the cab, the required level of concentration in executing the tasks, the adequacy of lateral visibility from the driving station, and the level of noise at the operator's position. This article provides guidance for improving the comfort of tractor workspace interiors. Agricultural machinery manufactures would benefit from research results, differentiating themselves from competitors.

Montefiore-Einstein Center for the Aging Brain: Preliminary Data.

PubMed

Verghese, Joe; Malik, Rubina; Zwerling, Jessica

2016-11-01

Given the multifaceted nature of dementia care management, an interdisciplinary comprehensive clinical approach is necessary. We describe our one-year experience with outpatient based dementia care at the Montefiore-Einstein Center for the Aging Brain (CAB) involving an multispecialty team of geriatricians, neurologists, and neuropsychologists, supported by geriatric psychiatrists, physiatrists, and social services. The goals of the CAB is to maximize dementia outcomes, including regular monitoring of patient's health and cognition, education and support to patients, their families and caregivers; initiation of pharmacological and non-pharmacological treatments as appropriate, and the facilitation of access to clinical trials. The CAB follows a consultative model where patients referred to the center receive a comprehensive three step evaluation and management plan from Geriatric, Neuropsychology and Neurology specialists that is shared with patient, caregivers and primary care physicians. Of the 366 patients seen for cognitive complaints in our first year, 71% were women with a mean age of 74 years. Self-identified ethnicity of patients included Caucasian (26%), African-American (25%), Hispanic (18%) and multiracial (5%). Common final diagnoses assigned at the CAB included mild cognitive impairment syndromes (31%), Alzheimer's disease (20%), mixed dementia (11%), vascular dementia (9%), Frontotemporal dementia (4%) and dementia with Lewy bodies (4%). Our one-year progress report indicates that an interdisciplinary clinical dementia care model is feasible in the outpatient setting as well as highly accepted by patients, caregivers and referring physicians. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

49 CFR 393.203 - Cab and body components.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Cab and body components. 393.203 Section 393.203... NECESSARY FOR SAFE OPERATION Frames, Cab and Body Components, Wheels, Steering, and Suspension Systems § 393.203 Cab and body components. (a) The cab compartment doors or door parts used as an entrance or exist...

Steering Control in a Low-Cost Driving Simulator: A Case for the Role of Virtual Vehicle Cab.

PubMed

Mecheri, Sami; Lobjois, Régis

2018-04-01

The aim of this study was to investigate steering control in a low-cost driving simulator with and without a virtual vehicle cab. In low-cost simulators, the lack of a vehicle cab denies driver access to vehicle width, which could affect steering control, insofar as locomotor adjustments are known to be based on action-scaled visual judgments of the environment. Two experiments were conducted in which steering control with and without a virtual vehicle cab was investigated in a within-subject design, using cornering and straight-lane-keeping tasks. Driving around curves without vehicle cab information made drivers deviate more from the lane center toward the inner edge in right (virtual cab = 4 ± 19 cm; no cab = 42 ± 28 cm; at the apex of the curve, p < .001) but not in left curves. More lateral deviation from the lane center toward the edge line was also found in driving without the virtual cab on straight roads (virtual cab = 21 ± 28 cm; no cab = 36 ± 27 cm; p < .001), whereas driving stability and presence ratings were not affected. In both experiments, the greater lateral deviation in the no-cab condition led to significantly more time driving off the lane. The findings strongly suggest that without cab information, participants underestimate the distance to the right edge of the car (in contrast to the left edge) and thus vehicle width. This produces considerable differences in the steering trajectory. Providing a virtual vehicle cab must be encouraged for more effectively capturing drivers' steering control in low-cost simulators.

49 CFR 230.80 - Cabs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... pipe, with properly rated valves and fittings. Live steam heating radiators must not be fastened to the cab. Exhaust steam radiators may be fastened to the cab. (c) Oil-burning steam locomotives. If the cab...

Enzymatic hydrolysis and fermentation of pretreated cashew apple bagasse with alkali and diluted sulfuric Acid for bioethanol production.

PubMed

Rocha, Maria Valderez Ponte; Rodrigues, Tigressa Helena Soares; de Macedo, Gorete Ribeiro; Gonçalves, Luciana R B

2009-05-01

The aim of this work was to optimize the enzymatic hydrolysis of the cellulose fraction of cashew apple bagasse (CAB) after diluted acid (CAB-H) and alkali pretreatment (CAB-OH), and to evaluate its fermentation to ethanol using Saccharomyces cerevisiae. Glucose conversion of 82 +/- 2 mg/g CAB-H and 730 +/- 20 mg/g CAB-OH was obtained when 2% (w/v) of solid and 30 FPU/g bagasse was used during hydrolysis at 45 degrees C, 2-fold higher than when using 15 FPU/g bagasse, 44 +/- 2 mg/g CAB-H, and 450 +/- 50 mg/g CAB-OH, respectively. Ethanol concentration and productivity, achieved after 6 h of fermentation, were 20.0 +/- 0.2 g L(-1) and 3.33 g L(-1) h(-1), respectively, when using CAB-OH hydrolyzate (initial glucose concentration of 52.4 g L(-1)). For CAB-H hydrolyzate (initial glucose concentration of 17.4 g L(-1)), ethanol concentration and productivity were 8.2 +/- 0.1 g L(-1) and 2.7 g L(-1) h(-1) in 3 h, respectively. Hydrolyzates fermentation resulted in an ethanol yield of 0.38 and 0.47 g/g glucose with pretreated CAB-OH and CAB-H, respectively. Ethanol concentration and productivity, obtained using CAB-OH hydrolyzate, were close to the values obtained in the conventional ethanol fermentation of cashew apple juice or sugar cane juice.

Myocardial Blood Flow in Man: Effects of Coronary Collateral Circulation and Coronary Artery Bypass Surgery

PubMed Central

Smith, Sidney C.; Gorlin, Richard; Herman, Michael V.; Taylor, Warren J.; Collins, John J.

1972-01-01

The effects of coronary artery bypass graft (CAB) and coronary collaterals (CC) on myocardial blood flow (MBF) were studied in 24 patients undergoing 29 CAB's. MBF after CAB was compared to preexisting MBF by intraoperatively injecting 133xenon via distal CAB with proximal CAB first occluded then open. Pressure gradients across bypassed obstructions were measured. The results were correlated with preoperative coronary arteriograms to determine the effects of CC on MBF and postobstructive perfusion pressures. Mean MBF was increased by CAB from 32±6 (se) ml/min per 100 g (CAB occluded) to 118±13 ml/min per 100 g (CAB open). The 133Xe clearance curves with CAB open were resolved into slow (19±2 ml/min per 100 g) and rapid (133±12 ml/min per 100 g) phases, suggesting that MBF remained heterogeneous after CAB. Vessels with less than 80% stenosis by angiography had pressure gradients less than 20 mm Hg across obstructions, high postobstructive perfusion pressures (75±7 mm Hg), and normal MBF (87±6 ml/min per 100 g) even with CAB occluded. Vessels with greater than 80% stenosis or total occlusion by angiography had significant pressure gradients with marked reduction of postobstructive MBF. No significant difference in postobstructive MBF was found when vessels with CC (21±4 ml/min per 100 g) were compared to those without CC (17±4 ml/min per 100 g) (P > 0.4). These studies demonstrate that (a) mean MBF increased 268% after CAB, (b) heterogeneous MBF persisted after CAB, (c) CC were not associated with significant increases in MBF, and (d) vessels with less than 80% stenosis had less than 20 mm Hg gradient with minimal effect on resting MBF. Images PMID:5056655

Virtual Planning at Work: A Tour of NASA Future Flight Central

NASA Technical Reports Server (NTRS)

McClenahen, Jim; Dorighi, Nancy S. (Technical Monitor)

2000-01-01

FutureFlight Central will permit integration of tomorrow's technologies in a risk-free simulation of any airport, airfield, and tower cab environment. The facility provides an opportunity for airlines to mitigate passenger delays by fine tuning airport hub operations, gate management and ramp movement procedures. It also allows airport managers an opportunity to study effects of various improvements at their airports. Finally, it enables air traffic controllers to provide feedback and to become familiar with new airport operations and technologies before final installation.

A distinct alleles and genetic recombination of pmrCAB operon in species of Acinetobacter baumannii complex isolates.

PubMed

Kim, Dae Hun; Ko, Kwan Soo

2015-07-01

To investigate pmrCAB sequence divergence in 5 species of Acinetobacter baumannii complex, a total of 80 isolates from a Korean hospital were explored. We evaluated nucleotide and amino acid polymorphisms of pmrCAB operon, and phylogenetic trees were constructed for each gene of prmCAB operon. Colistin and polymyxin B susceptibility was determined for all isolates, and multilocus sequence typing was also performed for A. baumannii isolates. Our results showed that each species of A. baumannii complex has divergent pmrCAB operon sequences. We identified a distinct pmrCAB allele allied with Acinetobacter nosocomialis in gene trees. Different grouping in each gene tree suggests sporadic recombination or emergence of pmrCAB genes among Acinetobacter species. Sequence polymorphisms among Acinetobacter species might not be associated with colistin resistance. We revealed that a distinct pmrCAB allele may be widespread across the continents such as North America and Asia and that sporadic genetic recombination or emergence of pmrCAB genes might occur. Copyright © 2015 Elsevier Inc. All rights reserved.

Clinical outcomes and nadir prostate-specific antigen (PSA) according to initial PSA levels in primary androgen deprivation therapy for metastatic prostate cancer.

PubMed

Kitagawa, Yasuhide; Ueno, Satoru; Izumi, Kouji; Kadono, Yoshifumi; Mizokami, Atsushi; Hinotsu, Shiro; Akaza, Hideyuki; Namiki, Mikio

2016-03-01

To investigate the clinical outcomes of metastatic prostate cancer patients and the relationship between nadir prostate-specific antigen (PSA) levels and different types of primary androgen deprivation therapy (PADT). This study utilized data from the Japan Study Group of Prostate Cancer registry, which is a large, multicenter, population-based database. A total of 2982 patients treated with PADT were enrolled. Kaplan-Meier analysis was used to compare progression-free survival (PFS) and overall survival (OS) in patients treated using combined androgen blockade (CAB) and non-CAB therapies. The relationships between nadir PSA levels and PADT type according to initial serum PSA levels were also investigated. Among the 2982 enrolled patients, 2101 (70.5 %) were treated with CAB. Although CAB-treated patients had worse clinical characteristics, their probability of PFS and OS was higher compared with those treated with a non-CAB therapy. These results were due to a survival benefit with CAB in patients with an initial PSA level of 500-1000 ng/mL. Nadir PSA levels were significantly lower in CAB patients than in non-CAB patients with comparable initial serum PSA levels. A small survival benefit for CAB in metastatic prostate cancer was demonstrated in a Japanese large-scale prospective cohort study. The clinical significance of nadir PSA levels following PADT was evident, but the predictive impact of PSA nadir on OS was different between CAB and non-CAB therapy.

76 FR 10889 - Record of Decision (ROD) for Grow the Army (GTA) Actions at Fort Lewis and the Yakima Training...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

... Management Command (IMCOM) has reviewed the Final Environmental Impact Statement (FEIS) for implementing Army... Preferred Alternative for the Proposed Action. The Preferred Alternative has several components that consist... stationing of a Combat Aviation Brigade (CAB) of up to 2,800 Soldiers. If all stationing components are...

7 CFR 1755.501 - Definitions applicable to §§ 1755.501 through 1755.510.

Code of Federal Regulations, 2011 CFR

2011-01-01

... travel use built on or permanently attached to a self-propelled motor vehicle chassis or on a chassis cab... the FCC rules in 47 CFR part 68. NID. Network interface device. Primary station protector. An assembly... and determined that: (1) Final assembly or manufacture of the equipment is completed in the United...

Gaming the GIG: A Brief Manifesto

DTIC Science & Technology

2005-09-01

have military themes and target a mass market . Such games must have relatively simple rules (to be playable by a diverse audience), and so they can be...4825 Mark Center Drive • Alexandria, Virginia 22311-1850 CAB D0013009.A1/Final September 2005 Gaming the GIG: A Brief Manifesto Peter P. Perla...24 Research and experimentation . . . . . . . . . . . . . . . 30 Game -based experimentation

Environmental context effects on craving among consumers of caffeinated alcohol beverages: Associations with aspects of impulsivity.

PubMed

Stamates, Amy L; Lau-Barraco, Cathy

2017-12-01

The present study primarily sought to (a) determine the effects of environmental context on subjective ratings of craving for alcohol and caffeinated alcohol beverages (CAB) and (b) test inhibitory control, a state behavioral aspect of impulsivity, as a mediator of the association between context and craving in a sample of consumers of CAB. A secondary aim was to examine the associations between trait impulsivity and subjective craving for alcohol and CAB. Participants were 143 (67.1% female) college CAB drinkers. Participants were randomized into either a simulated bar context condition or neutral context condition and completed measures of alcohol use, CAB use, trait impulsivity, inhibitory control on a go/no-go task, and subjective craving for alcohol and CAB. Findings revealed that participants in the simulated bar condition, as compared with those in the neutral condition, reported more subjective craving for alcohol and for CAB; however, alcohol and CAB-specific craving were not different overall or as a function of context. The association between context and subjective craving for alcohol was not mediated by inhibitory control. Trait impulsivity was positively associated with alcohol and CAB-specific craving at baseline and post context exposure, and this finding was similar across both conditions. Therefore, the current investigation suggests that consumers of CAB may be sensitive to alcohol contexts as indicated by greater responses in alcohol and CAB-specific craving. However, inhibitory control did not explain this association. Future research may benefit from examining other potential mechanisms that explain the relationship between context and craving among CAB consumers. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Building Services Contracts. 552.232-72 Section 552.232-72 Federal Acquisition Regulations System GENERAL... and Clauses 552.232-72 Final Payment Under Building Services Contracts. As prescribed in 532.904(c), insert the following clause: Final Payment Under Building Services Contracts (NOV 2009) Before final...

48 CFR 32.605 - Final decisions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS CONTRACT FINANCING Contract Debts 32.605 Final decisions. (a) The contracting officer shall issue a final decision as required by 33.211 if— (1) The contracting officer and the contractor are unable... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Final decisions. 32.605...

Locomotive cab design development. Volume 1 : analysis of locomotive cab environment & development of cab design alternatives

DOT National Transportation Integrated Search

1976-10-01

This report presents an analysis of the line haul freight : engineer's working and living environment, the resultant locomotive : cab design and design alternatives. The analysis is based on a : delineation of functional requirements found in current...

49 CFR 236.805 - Signal, cab.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Signal, cab. 236.805 Section 236.805..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.805 Signal, cab. A signal located in engineman's compartment or cab, indicating a condition affecting the...

49 CFR 236.805 - Signal, cab.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Signal, cab. 236.805 Section 236.805..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.805 Signal, cab. A signal located in engineman's compartment or cab, indicating a condition affecting the...

Locomotive cab design development. volume III: design application analysis - Interim report

DOT National Transportation Integrated Search

1976-10-01

In Volume II of this service of reports on Locomotive Cab Design Development, changes were recommended in the layout and equipment content of locomotive cabs. This report studies the impact of these changes on the interface of the cab with the rest o...

49 CFR 236.805 - Signal, cab.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Signal, cab. 236.805 Section 236.805..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.805 Signal, cab. A signal located in engineman's compartment or cab, indicating a condition affecting the...

49 CFR 236.805 - Signal, cab.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Signal, cab. 236.805 Section 236.805..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.805 Signal, cab. A signal located in engineman's compartment or cab, indicating a condition affecting the...

49 CFR 236.805 - Signal, cab.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Signal, cab. 236.805 Section 236.805..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.805 Signal, cab. A signal located in engineman's compartment or cab, indicating a condition affecting the...

49 CFR 229.127 - Cab lights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Cab lights. 229.127 Section 229.127 Transportation... lights. (a) Each locomotive shall have cab lights which will provide sufficient illumination for the... normal positions in the cab. These lights shall be located, constructed, and maintained so that light...

49 CFR 229.127 - Cab lights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Cab lights. 229.127 Section 229.127 Transportation... lights. (a) Each locomotive shall have cab lights which will provide sufficient illumination for the... normal positions in the cab. These lights shall be located, constructed, and maintained so that light...

49 CFR 229.127 - Cab lights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Cab lights. 229.127 Section 229.127 Transportation... lights. (a) Each locomotive shall have cab lights which will provide sufficient illumination for the... normal positions in the cab. These lights shall be located, constructed, and maintained so that light...

49 CFR 229.127 - Cab lights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Cab lights. 229.127 Section 229.127 Transportation... lights. (a) Each locomotive shall have cab lights which will provide sufficient illumination for the... normal positions in the cab. These lights shall be located, constructed, and maintained so that light...

49 CFR 229.127 - Cab lights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Cab lights. 229.127 Section 229.127 Transportation... lights. (a) Each locomotive shall have cab lights which will provide sufficient illumination for the... normal positions in the cab. These lights shall be located, constructed, and maintained so that light...

49 CFR 236.514 - Interconnection of cab signal system with roadway signal system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.514 Interconnection of cab signal system with roadway signal system. The automatic cab signal system shall be...

49 CFR 236.511 - Cab signals controlled in accordance with block conditions stopping distance in advance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards... automatic cab signal system shall be arranged so that cab signals will be continuously controlled in...

The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)

PubMed Central

Zhou, Hongyan; Zhang, Wensong; Bi, Miaomiao; Wu, Jie

2016-01-01

Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory responses, immune response, cell signal transduction, matrix metalloproteinase production and vascular factors in CAB are discussed. Previous evidence indicates that peroxisome proliferator-activated receptor γ (PPAR-γ) agonists suppress immune responses, inflammation, corneal fibrosis and NV. This review also discusses the role of PPAR-γ as an anti-inflammatory, anti-fibrotic and anti-angiogenic agent in the treatment of CAB, as well as the potential role of PPAR-γ in the pathological process of CAB. There have been numerous studies evaluating the clinical profiles of CAB, and the aim of this systematic review was to summarize the evidence regarding the treatment of CAB with PPAR-γ agonists. PMID:27499172

49 CFR 236.512 - Cab signal indication when locomotive enters block where restrictive conditions obtain.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Cab signal indication when locomotive enters block... Systems Standards § 236.512 Cab signal indication when locomotive enters block where restrictive... within a block, wherein any condition described in § 236.205 obtains, the cab signals shall indicate...

49 CFR 238.447 - Train operator's controls and power car cab layout.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Train operator's controls and power car cab layout... layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance.... (d) Power car cab information displays shall be designed with the following characteristics: (1...

49 CFR 238.447 - Train operator's controls and power car cab layout.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Train operator's controls and power car cab layout... layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance.... (d) Power car cab information displays shall be designed with the following characteristics: (1...

49 CFR 238.447 - Train operator's controls and power car cab layout.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Train operator's controls and power car cab layout... layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance.... (d) Power car cab information displays shall be designed with the following characteristics: (1...

49 CFR 236.512 - Cab signal indication when locomotive enters block where restrictive conditions obtain.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.512 Cab signal indication when locomotive enters block where restrictive conditions obtain. The automatic cab signal system shall be arranged so that when a locomotive enters or is...

Detoxification of VX by Chloramine-B. Final report, August 1989-April 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Y.C.; Szafraniec, L.L.; Beaudry, W.T.

1993-07-01

At ambient temperature, the nerve agent O-ethyl S-2(diisopropylamino)ethyl methylphosphonothiolate (VX), can be detoxified in an aqueous solution of Chloramine-B CAB, C6H5SQ2N(Cl)Na only in the presence of sufficient acid (pH 3). The thiolo sulfur is first attacked by the reactive species, benzene chlorosulfonamide, to form a chlorosulfonium ion intermediate followed by hydrolysis and substitution reactions with the sulfonamide anion at the P-S bond. These reactions produce strongly acidic products, which further accelerate the initial reaction. Consequently, one of the acidic hydrolysis products of VX, the toxic S-2-(diisopropylamino)ethyl methylphosphonothioic acid (EA 2192) reacts with CAB instantaneously. This acid-catalyzed mechanism is similar tomore » that reported for bivalent sulfides; direct attack by active chlorine is considered insignificant. A neutral VX analog, O,S-diethyl methylphoshonothiolate, reacts with CAB rapidly in H20 with an initial pH of 8.9 but requires the addition of 0.006 N (H+) for the reaction to occur in D20. By comparison, bivalent sulfides are more reactive than the phosphonothiolates, in general, and can be rapidly oxidized in both H20 and D20, even at high pH values. Chloramine-B, VX, Bivalent sulfide, Benzenechlorosulfonamide, Thiolo sulfur, Phosphonothiolate.« less

Impulsivity and Alcohol Demand in relation to Combined Alcohol and Caffeine Use

PubMed Central

Amlung, Michael; Few, Lauren R.; Howland, Jonathan; Rohsenow, Damaris J.; Metrik, Jane; MacKillop, James

2014-01-01

Problematic alcohol use among college students continues to be a prominent concern in the United States, including the growing trend of consuming caffeine with alcoholic beverages (CABs). Epidemiologically, CAB use is associated with incremental risks from drinking, although these relationships could be due to common predisposing factors rather than specifically due to CABs. This study investigated the relationship between CAB use, alcohol misuse, and person-level characteristics including impulsive personality traits, delayed reward discounting, and behavioral economic demand for alcohol use. Participants were 273 regularly drinking undergraduate students. Frequency of CAB use was assessed over the past month. A multidimensional assessment of impulsivity included the UPPS-P questionnaire and a validated, questionnaire-based measure of delayed reward discounting. Demand was assessed via a hypothetical alcohol purchase task. Frequency of CAB consumption was significantly higher in males compared to females and was also associated with higher impulsivity on the majority of the UPPS-P subscales, steeper delayed reward discounting, and greater demand for alcohol. Significant correlations between CAB use and both alcohol demand and lack of premeditation remained present after including level of alcohol misuse in partial correlations. In a hierarchical linear regression incorporating demographic, demand, and impulsivity variables, CAB frequency continued to be a significant predictor of hazardous alcohol use. These results suggest that although there are significant associations between CAB consumption and gender, impulsivity, and alcohol demand, CAB use continues to be associated with alcohol misuse after controlling for these variables. PMID:24364537

Cabotegravir long acting injection protects macaques against intravenous challenge with SIVmac251.

PubMed

Andrews, Chasity D; Bernard, Leslie St; Poon, Amanda Yee; Mohri, Hiroshi; Gettie, Natanya; Spreen, William R; Gettie, Agegnehu; Russell-Lodrigue, Kasi; Blanchard, James; Hong, Zhi; Ho, David D; Markowitz, Martin

2017-02-20

We evaluated the effectiveness of cabotegravir (CAB; GSK1265744 or GSK744) long acting as preexposure prophylaxis (PrEP) against intravenous simian immunodeficiency virus (SIV) challenge in a model that mimics blood transfusions based on the per-act probability of infection. CAB long acting is an integrase strand transfer inhibitor formulated as a 200 mg/ml injectable nanoparticle suspension that is an effective PrEP agent against rectal and vaginal simian/human immunodeficiency virus transmission in macaques. Three groups of rhesus macaques (n = 8 per group) were injected intramuscularly with CAB long acting and challenged intravenously with 17 animal infectious dose 50% SIVmac251 on week 2. Group 1 was injected with 50 mg/kg on week 0 and 4 to evaluate the protective efficacy of the CAB long-acting dose used in macaque studies mimicking sexual transmission. Group 2 was injected with 50 mg/kg on week 0 to evaluate the necessity of the second injection of CAB long acting for protection against intravenous challenge. Group 3 was injected with 25 mg/kg on week 0 and 50 mg/kg on week 4 to correlate CAB plasma concentrations at the time of challenge with protection. Five additional macaques remained untreated as controls. CAB long acting was highly protective with 21 of the 24 CAB long-acting-treated macaques remaining aviremic, resulting in 88% protection. The plasma CAB concentration at the time of virus challenge appeared to be more important for protection than sustaining therapeutic plasma concentrations with the second CAB long acting injection. These results support the clinical investigation of CAB long acting as PrEP in people who inject drugs.

Waste Workers’ Exposure to Airborne Fungal and Bacterial Species in the Truck Cab and During Waste Collection

PubMed Central

Madsen, Anne Mette; Alwan, Taif; Ørberg, Anders; Uhrbrand, Katrine; Jørgensen, Marie Birk

2016-01-01

A large number of people work with garbage collection, and exposure to microorganisms is considered an occupational health problem. However, knowledge on microbial exposure at species level is limited. The aim of the study was to achieve knowledge on waste collectors’ exposure to airborne inhalable fungal and bacterial species during waste collection with focus on the transport of airborne microorganisms into the truck cab. Airborne microorganisms were collected with samplers mounted in the truck cab, on the workers’ clothes, and outdoors. Fungal and bacterial species were quantified and identified. The study showed that the workers were exposed to between 112 and 4.8×104 bacteria m−3 air and 326 and 4.6×104 fungi m−3 air. The personal exposures to bacteria and fungi were significantly higher than the concentrations measured in the truck cabs and in the outdoor references. On average, the fungal and bacterial concentrations in truck cabs were 111 and 7.7 times higher than outdoor reference measurements. In total, 23 fungal and 38 bacterial species were found and identified. Most fungal species belonged to the genus Penicillium and in total 11 Penicillium species were found. Identical fungal species were often found both in a personal sample and in the same person’s truck cab, but concentrations were on average 27 times higher in personal samples. Concentrations of fungal and bacterial species found only in the personal samples were lower than concentrations of species also found in truck cabs. Skin-related bacteria constituted a large fraction of bacterial isolates found in personal and truck cab samples. In total, six Staphylococcus species were found. In outdoor samples, no skin-related bacteria were found. On average, concentrations of bacterial species found both in the truck cab and personal samples were 77 times higher in personal samples than in truck cab samples. In conclusion, high concentrations of fungi were found in truck cabs, but the highest concentrations were found in personal samples; fungal and bacterial species found in high concentrations in personal samples were also found in truck cabs, but in lower concentrations indicating that both fungi and bacteria are transported by the workers into the truck cab, and are subsequently aerosolized in the truck cab. PMID:27098185

49 CFR 238.409 - Forward end structures of power car cabs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Forward end structures of power car cabs. 238.409... II Passenger Equipment § 238.409 Forward end structures of power car cabs. This section contains requirements for the forward end structure of the cab of a power car. (A conceptual implementation of this end...

49 CFR 238.447 - Train operator's controls and power car cab layout.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Train operator's controls and power car cab layout... Specific Requirements for Tier II Passenger Equipment § 238.447 Train operator's controls and power car cab layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance...

49 CFR 238.409 - Forward end structures of power car cabs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Forward end structures of power car cabs. 238.409... II Passenger Equipment § 238.409 Forward end structures of power car cabs. This section contains requirements for the forward end structure of the cab of a power car. (A conceptual implementation of this end...

49 CFR 238.411 - Rear end structures of power car cabs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Rear end structures of power car cabs. 238.411... II Passenger Equipment § 238.411 Rear end structures of power car cabs. The rear end structure of the cab of a power car shall be designed to include the following elements, or their structural equivalent...

49 CFR 238.411 - Rear end structures of power car cabs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Rear end structures of power car cabs. 238.411... II Passenger Equipment § 238.411 Rear end structures of power car cabs. The rear end structure of the cab of a power car shall be designed to include the following elements, or their structural equivalent...

49 CFR 238.447 - Train operator's controls and power car cab layout.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Train operator's controls and power car cab layout... Specific Requirements for Tier II Passenger Equipment § 238.447 Train operator's controls and power car cab layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance...

49 CFR 238.411 - Rear end structures of power car cabs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Rear end structures of power car cabs. 238.411... II Passenger Equipment § 238.411 Rear end structures of power car cabs. The rear end structure of the cab of a power car shall be designed to include the following elements, or their structural equivalent...

49 CFR 238.409 - Forward end structures of power car cabs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Forward end structures of power car cabs. 238.409... II Passenger Equipment § 238.409 Forward end structures of power car cabs. This section contains requirements for the forward end structure of the cab of a power car. (A conceptual implementation of this end...

49 CFR 238.411 - Rear end structures of power car cabs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Rear end structures of power car cabs. 238.411... II Passenger Equipment § 238.411 Rear end structures of power car cabs. The rear end structure of the cab of a power car shall be designed to include the following elements, or their structural equivalent...

49 CFR 238.409 - Forward end structures of power car cabs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Forward end structures of power car cabs. 238.409... II Passenger Equipment § 238.409 Forward end structures of power car cabs. This section contains requirements for the forward end structure of the cab of a power car. (A conceptual implementation of this end...

49 CFR 238.411 - Rear end structures of power car cabs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Rear end structures of power car cabs. 238.411... II Passenger Equipment § 238.411 Rear end structures of power car cabs. The rear end structure of the cab of a power car shall be designed to include the following elements, or their structural equivalent...

49 CFR 238.409 - Forward end structures of power car cabs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Forward end structures of power car cabs. 238.409... II Passenger Equipment § 238.409 Forward end structures of power car cabs. This section contains requirements for the forward end structure of the cab of a power car. (A conceptual implementation of this end...

Impulsivity and alcohol demand in relation to combined alcohol and caffeine use.

PubMed

Amlung, Michael; Few, Lauren R; Howland, Jonathan; Rohsenow, Damaris J; Metrik, Jane; MacKillop, James

2013-12-01

Problematic alcohol use among college students continues to be a prominent concern in the United States, including the growing trend of consuming caffeinated alcoholic beverages (CABs). Epidemiologically, CAB use is associated with incremental risks from drinking, although these relationships could be due to common predisposing factors rather than specifically due to CABs. This study investigated the relationship between CAB use, alcohol misuse, and person-level characteristics, including impulsive personality traits, delayed reward discounting, and behavioral economic demand for alcohol use. Participants were 273 regularly drinking undergraduate students. Frequency of CAB use was assessed over the past month. A multidimensional assessment of impulsivity included the UPPS-P questionnaire, which measures positive and negative urgency, premeditation (lack thereof), perseverance (lack thereof), and sensation seeking (Lynam, Smith, Whiteside, & Cyders, 2007), and a validated questionnaire-based measure of delayed reward discounting. Demand was assessed via a hypothetical alcohol purchase task. Frequency of CAB consumption was significantly higher in men than in women and was also associated with higher impulsivity on the majority of the UPPS-P subscales, steeper delayed reward discounting, and greater demand for alcohol. Significant correlations between CAB use and both alcohol demand and lack of premeditation remained present after including level of alcohol misuse in partial correlations. In a hierarchical linear regression incorporating demographic, demand, and impulsivity variables, CAB frequency continued to be a significant predictor of hazardous alcohol use. These results suggest that although there are significant associations between CAB consumption and gender, impulsivity, and alcohol demand, CAB use continues to be associated with alcohol misuse after controlling for these variables.

Profiling Antibody Responses to Infections by Chlamydia abortus Enables Identification of Potential Virulence Factors and Candidates for Serodiagnosis

PubMed Central

Forsbach-Birk, Vera; Foddis, Corinna; Simnacher, Ulrike; Wilkat, Max; Longbottom, David; Walder, Gernot; Benesch, Christiane; Ganter, Martin; Sachse, Konrad; Essig, Andreas

2013-01-01

Enzootic abortion of ewes (EAE) due to infection with the obligate intracellular pathogen Chlamydia (C.) abortus is an important zoonosis leading to considerable economic loss to agriculture worldwide. The pathogen can be transmitted to humans and may lead to serious infection in pregnant women. Knowledge about epidemiology, clinical course and transmission to humans is hampered by the lack of reliable diagnostic tools. Immunoreactive proteins, which are expressed in infected animals and humans, may serve as novel candidates for diagnostic marker proteins and represent putative virulence factors. In order to broaden the spectrum of immunogenic C. abortus proteins we applied 2D immunoblot analysis and screening of an expression library using human and animal sera. We have identified 48 immunoreactive proteins representing potential diagnostic markers and also putative virulence factors, such as CAB080 (homologue of the “macrophage infectivity potentiator”, MIP), CAB167 (homologue of the “translocated actin recruitment protein”, TARP), CAB712 (homologue of the “chlamydial protease-like activity factor”, CPAF), CAB776 (homologue of the “Polymorphic membrane protein D”, PmpD), and the “hypothetical proteins” CAB063, CAB408 and CAB821, which are predicted to be type III secreted. We selected two putative virulence factors for further characterization, i.e. CAB080 (cMIP) and CAB063, and studied their expression profiles at transcript and protein levels. Analysis of the subcellular localization of both proteins throughout the developmental cycle revealed CAB063 being the first C. abortus protein shown to be translocated to the host cell nucleus. PMID:24260366

Enhanced enzymatic hydrolysis and ethanol production from cashew apple bagasse pretreated with alkaline hydrogen peroxide.

PubMed

da Costa, Jessyca Aline; Marques, José Edvan; Gonçalves, Luciana Rocha Barros; Rocha, Maria Valderez Ponte

2015-03-01

The effect of combinations and ratios between different enzymes has been investigated in order to assess the optimal conditions for hydrolysis of cashew apple bagasse pretreated with alkaline hydrogen peroxide (the solids named CAB-AHP). The separate hydrolysis and fermentation (SHF) and simultaneous saccharification and fermentation (SSF) processes were evaluated in the ethanol production. The enzymatic hydrolysis conducted with cellulase complex and β-glucosidase in a ratio of 0.61:0.39, enzyme loading of 30FPU/g(CAB-AHP) and 66CBU/g(CAB-AHP), respectively, using 4% cellulose from CAB-AHP, turned out to be the most effective conditions, with glucose and xylose yields of 511.68 mg/g(CAB-AHP) and 237.8 mg/g(CAB-AHP), respectively. Fermentation of the pure hydrolysate by Kluyveromyces marxianus ATCC 36907 led to an ethanol yield of 61.8kg/ton(CAB), corresponding to 15 g/L ethanol and productivity of 3.75 g/( Lh). The ethanol production obtained for SSF process using K. marxianus ATCC 36907 was 18 g/L corresponding to 80% yield and 74.2kg/ton(CAB). Copyright © 2014 Elsevier Ltd. All rights reserved.

In vivo binding of hot pepper bZIP transcription factor CabZIP1 to the G-box region of pathogenesis-related protein 1 promoter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Boo-Ja; Park, Chang-Jin; Kim, Sung-Kyu

2006-05-26

We find that salicylic acid and ethephon treatment in hot pepper increases the expression of a putative basic/leucine zipper (bZIP) transcription factor gene, CabZIP1. CabZIP1 mRNA is expressed ubiquitously in various organs. The green fluorescent protein-fused transcription factor, CabZIP1::GFP, can be specifically localized to the nucleus, an action that is consistent with the presence of a nuclear localization signal in its protein sequence. Transient overexpression of the CabZIP1 transcription factor results in an increase in PR-1 transcripts level in Nicotiana benthamiana leaves. Using chromatin immunoprecipitation, we demonstrate that CabZIP1 binds to the G-box elements in native promoter of the hotmore » pepper pathogenesis-related protein 1 (CaPR-1) gene in vivo. Taken together, our results suggest that CabZIP1 plays a role as a transcriptional regulator of the CaPR-1 gene.« less

Individual Members of the Cab Gene Family Differ Widely in Fluence Response.

PubMed Central

White, M. J.; Kaufman, L. S.; Horwitz, B. A.; Briggs, W. R.; Thompson, W. F.

1995-01-01

Chlorophyll a/b-binding protein genes (Cab genes) can be extremely sensitive to light. Transcript accumulation following a red light pulse increases with fluence over 8 orders of magnitude (L.S. Kaufman, W.F. Thompson, W.R. Briggs [1984] Science 226: 1447-1449). We have constructed fluence-response curves for individual Cab genes. At least two Cab genes (Cab-8 and AB96) show a very low fluence response to a single red light pulse. In contrast, two other Cab genes (AB80 and AB66) fail to produce detectable transcript following a single pulse of either red or blue light but are expressed in continuous red light. Thus, very low fluence responses and high irradiance responses occur in the same gene family. PMID:12228352

microRNA-451a regulates colorectal cancer proliferation in response to radiation.

PubMed

Ruhl, Rebecca; Rana, Shushan; Kelley, Katherine; Espinosa-Diez, Cristina; Hudson, Clayton; Lanciault, Christian; Thomas, Charles R; Liana Tsikitis, V; Anand, Sudarshan

2018-05-03

Colorectal cancer (CRC) is a leading cause of cancer-related death. The biologic response of CRC to standard of care adjuvant therapies such as chemotherapy and radiation are poorly understood. MicroRNAs (miRs) have been shown to affect CRC progression and metastasis. Therefore, we hypothesized that specific miRs modulate CRC response to chemoradiation. In this study, we used miR expression profiling and discovered a set of microRNAs upregulated rapidly in response to either a single 2 Gy dose fraction or a 10 Gy dose of γ-radiation in mouse colorectal carcinoma models. We used gain and loss-of-function studies in 2D and 3Dcell proliferation assays and colony formation assays to understand the role of the top miR candidate from our profiling. We used Student's T-tests for simple comparisons and two-factor ANOVA for evaluating significance. The most upregulated candidate at early time points in our signature, miR-451a inhibited tumor cell proliferation and attenuated surviving fraction in longer-term cultures. Conversely, inhibition of miR-451a increased proliferation, tumorsphere formation, and surviving fraction of tumor cells. Using a bioinformatics approach, we identified four genes, CAB39, EMSY, MEX3C, and EREG, as targets of miR-451a. Transfection of miR-451a decreased both mRNA and protein levels of these targets. Importantly, we found miR-451a expression was high and CAB39, EMSY levels were low in a small subset of rectal cancer patients who had a partial response to chemoradiation when compared to patients that had no response. Finally, analysis of a TCGA colorectal cancer dataset revealed that CAB39 and EMSY are upregulated at the protein level in a significant number of CRC patients. Higher levels of CAB39 and EMSY correlated with poorer overall survival. Taken together, our data indicates miR-451a is induced by radiation and may influence colorectal carcinoma proliferation via CAB39 and EMSY pathways.

Pepper CabZIP63 acts as a positive regulator during Ralstonia solanacearum or high temperature-high humidity challenge in a positive feedback loop with CaWRKY40.

PubMed

Shen, Lei; Liu, Zhiqin; Yang, Sheng; Yang, Tong; Liang, Jiaqi; Wen, Jiayu; Liu, Yanyan; Li, Jiazhi; Shi, Lanping; Tang, Qian; Shi, Wei; Hu, Jiong; Liu, Cailing; Zhang, Yangwen; Lin, Wei; Wang, Rongzhang; Yu, Huanxin; Mou, Shaoliang; Hussain, Ansar; Cheng, Wei; Cai, Hanyang; He, Li; Guan, Deyi; Wu, Yang; He, Shuilin

2016-04-01

CaWRKY40 is known to act as a positive regulator in the response of pepper (Capsicum annuum) to Ralstonia solanacearum inoculation (RSI) or high temperature-high humidity (HTHH), but the underlying mechanism remains elusive. Herein, we report that CabZIP63, a pepper bZIP family member, participates in this process by regulating the expression of CaWRKY40. CabZIP63 was found to localize in the nuclei, be up-regulated by RSI or HTHH, bind to promoters of both CabZIP63(pCabZIP63) and CaWRKY40(pCaWRKY40), and activate pCabZIP63- and pCaWRKY40-driven β-glucuronidase expression in a C- or G-box-dependent manner. Silencing of CabZIP63 by virus-induced gene silencing (VIGS) in pepper plants significantly attenuated their resistance to RSI and tolerance to HTHH, accompanied by down-regulation of immunity- or thermotolerance-associated CaPR1, CaNPR1, CaDEF1, and CaHSP24. Hypersensitive response-mediated cell death and expression of the tested immunity- and thermotolerance-associated marker genes were induced by transient overexpression (TOE) of CabZIP63, but decreased by that of CabZIP63-SRDX. Additionally, binding of CabZIP63 to pCaWRKY40 was up-regulated by RSI or HTHH, and the transcript level of CaWRKY40 and binding of CaWRKY40 to the promoters of CaPR1, CaNPR1, CaDEF1 and CaHSP24 were up-regulated by TOE of CabZIP63. On the other hand, CabZIP63 was also up-regulated transcriptionally by TOE of CaWRKY40. The data suggest collectively that CabZIP63 directly or indirectly regulates the expression of CaWRKY40 at both the transcriptional and post-transcriptional level, forming a positive feedback loop with CaWRKY40 during pepper's response to RSI or HTHH. Altogether, our data will help to elucidate the underlying mechanism of crosstalk between pepper's response to RSI and HTHH. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

49 CFR Appendix F to Part 238 - Alternative Dynamic Performance Requirements for Front End Structures of Cab Cars and MU Locomotives

Code of Federal Regulations, 2013 CFR

2013-10-01

... of cab cars and MU locomotives with shaped-noses or crash energy management designs, or both. In any... Front End Structures of Cab Cars and MU Locomotives F Appendix F to Part 238 Transportation Other... Performance Requirements for Front End Structures of Cab Cars and MU Locomotives As specified in § 238.209(b...

49 CFR Appendix F to Part 238 - Alternative Dynamic Performance Requirements for Front End Structures of Cab Cars and MU Locomotives

Code of Federal Regulations, 2012 CFR

2012-10-01

... of cab cars and MU locomotives with shaped-noses or crash energy management designs, or both. In any... Front End Structures of Cab Cars and MU Locomotives F Appendix F to Part 238 Transportation Other... Performance Requirements for Front End Structures of Cab Cars and MU Locomotives As specified in § 238.209(b...

49 CFR Appendix F to Part 238 - Alternative Dynamic Performance Requirements for Front End Structures of Cab Cars and MU Locomotives

Code of Federal Regulations, 2011 CFR

2011-10-01

... of cab cars and MU locomotives with shaped-noses or crash energy management designs, or both. In any... Front End Structures of Cab Cars and MU Locomotives F Appendix F to Part 238 Transportation Other... Performance Requirements for Front End Structures of Cab Cars and MU Locomotives As specified in § 238.209(b...

49 CFR Appendix F to Part 238 - Alternative Dynamic Performance Requirements for Front End Structures of Cab Cars and MU Locomotives

Code of Federal Regulations, 2014 CFR

2014-10-01

... of cab cars and MU locomotives with shaped-noses or crash energy management designs, or both. In any... Front End Structures of Cab Cars and MU Locomotives F Appendix F to Part 238 Transportation Other... Performance Requirements for Front End Structures of Cab Cars and MU Locomotives As specified in § 238.209(b...

49 CFR Appendix F to Part 238 - Alternative Dynamic Performance Requirements for Front End Structures of Cab Cars and MU Locomotives

Code of Federal Regulations, 2010 CFR

2010-10-01

... Front End Structures of Cab Cars and MU Locomotives F Appendix F to Part 238 Transportation Other... Performance Requirements for Front End Structures of Cab Cars and MU Locomotives As specified in § 238.209(b... and allow for the application of dynamic performance criteria to cab cars and MU locomotives as an...

Comparison of Adverse Events and Hospital Length of Stay Associated With Various Amphotericin B Formulations

PubMed Central

Wade, Rolin L.; Chaudhari, Paresh; Natoli, Jaime L.; Taylor, Robert J.; Nathanson, Brian H.; Horn, David

2013-01-01

Purpose: Patients with invasive fungal infections are often treated initially with conventional amphotericin B deoxycholate (CAB), followed by a switch to lipid-based formulations of amphotericin B (LF-AMB). Our study examined adverse events and hospital length of stay (LOS) among adults who received LF-AMB exclusively or CAB followed by LF-AMB (CAB/LF-AMB). Methods: Data were extracted from the Cerner Health Facts database. The study included adults with evidence of infection by Aspergillus, Candida, or Cryptococcus in addition to either renal insufficiency, a clinical condition suggesting intolerance to CAB, or CAB exposure within 90 days of admission. Nephrotoxicity was defined as a serum creatinine (SCr) level exceeding a 100% increase from baseline and an absolute level above 1.2 mg/dL. We used a hierarchical mixed-effect logistic regression model with nephrotoxicity as the outcome for the multivariate analysis. Results: The study included 327 LF-AMB and 81 CAB/LF-AMB patients with similar demographics and baseline SCr values. The mean pre-to-post percentage increase in SCr levels was greater for CAB/LF-AMB (122.9%) compared with LF-AMB (62.2%) (P < 0.001). The multivariate-adjusted odds ratio of nephrotoxicity was 5.93, for a 95% confidence interval of 2.92 to 12.05 (P < 0.001) for CAB/LF-AMB compared with LF-AMB. Hypokalemia, hypomagnesemia, and infusion-related reactions were more frequent with CAB/LF-AMB. Compared with the LF-AMB group, the CAB/LF-AMB patients had a longer post-amphotericin B LOS (24.1 days vs. 15.7 days, respectively; P < 0.001), with a marginal effect of 4.5 days longer for those receiving CAB/LF-AMB (P = 0.016). Conclusion: In this retrospective study, we noted a significantly longer post-amphotericin B LOS and a greater frequency of adverse events, including nephrotoxicity, for patients whose initial treatment was CAB and who were switched to LF-AMB, compared with patients who received LF-AMB only. PMID:23946621

The use of caffeinated alcoholic beverages among underage drinkers: Results of a national survey

PubMed Central

Kponee, Kalé Z.; Siegel, Michael; Jernigan, David H.

2013-01-01

Objective The mixing of alcoholic beverages with caffeine has been identified as a public health problem among college students; however, little is known about the consumption of such drinks among younger adolescents. We estimated the prevalence of caffeinated alcoholic beverage (CAB) use among a wide age range of underage drinkers, examined differences in traditional (i.e. self-mixed alcoholic beverages with soda, coffee and tea) and non-traditional CAB use (pre-mixed caffeinated alcoholic beverages or self-mixed alcoholic beverages with energy drinks or energy shots) among underage drinkers by age and other demographic characteristics, and examined differences in hazardous drinking behavior between CAB and non-CAB users. Methods We used an existing internet panel maintained by Knowledge Networks, Inc. to assess the use of pre-mixed and self-mixed CABs in the past 30 days among a national sample of 1,031 youth drinkers ages 13–20. We conducted logistic regression analyses to estimate the relationship between traditional and non-traditional CAB use and risky drinking behavior as well as adverse outcomes of drinking, while controlling for age, gender, race/ethnicity, income, and general risk-taking (seat belt use). Results The overall prevalence of CAB use in the sample of underage drinkers was 52.4% (95% confidence interval [CI], 47.4%–57.4%). CAB prevalence was 48.4% among 13–15 year-old drinkers, 45.3% among 16–18 year-old drinkers, and 58.4% among 19–20 year-old drinkers. After controlling for other variables, we found a continuum of risk with non-traditional CAB use most significantly associated with binge drinking (odds ratio [OR] = 6.3), fighting (OR = 4.4), and alcohol-related injuries (OR = 5.6) Conclusions The problem of caffeinated alcoholic beverage use is not restricted to college-aged youth. The prevalence of CAB use among underage drinkers is higher than previously thought and begins in early adolescence. Adolescents who consume CABs, and particularly non-traditional CABs, are at increased risk of adverse outcomes. PMID:24161375

48 CFR 1552.211-77 - Final reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... reports. As prescribed in 1511.011-77, insert this contract clause when a contract requires both a draft and a final report. FINAL REPORTS (SEP 2013) (a) “Draft Report”__The Contractor shall submit to the Contracting Officer's Representative __ copies of the draft final report on or before ___ (date) __ The...

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

Field Assessment of Enclosed Cab Filtration System Performance Using Particle Counting Measurements

PubMed Central

Organiscak, John A.; Cecala, Andrew B.; Noll, James D.

2015-01-01

Enclosed cab filtration systems are typically used on mobile mining equipment to reduce miners’ exposure to airborne dust generated during mining operations. The National Institute for Occupational Safety and Health (NIOSH) Office of Mine Safety and Health Research (OMSHR) has recently worked with a mining equipment manufacturer to examine a new cab filtration system design for underground industrial minerals equipment. This cab filtration system uses a combination of three particulate filters to reduce equipment operators’ exposure to dust and diesel particulates present in underground industrial mineral mines. NIOSH initially examined this cab filtration system using a two-instrument particle counting method at the equipment company’s manufacturing shop facility to assess several alternative filters. This cab filtration system design was further studied on several pieces of equipment during a two- to seven-month period at two underground limestone mines. The two-instrument particle counting method was used outside the underground mine at the end of the production shifts to regularly test the cabs’ long-term protection factor performance with particulates present in the ambient air. This particle counting method showed that three of the four cabs achieved protection factors greater than 1,000 during the field studies. The fourth cab did not perform at this level because it had a damaged filter in the system. The particle counting measurements of submicron particles present in the ambient air were shown to be a timely and useful quantification method in assessing cab performance during these field studies. PMID:23915268

CABS-flex predictions of protein flexibility compared with NMR ensembles

PubMed Central

Jamroz, Michal; Kolinski, Andrzej; Kmiecik, Sebastian

2014-01-01

Motivation: Identification of flexible regions of protein structures is important for understanding of their biological functions. Recently, we have developed a fast approach for predicting protein structure fluctuations from a single protein model: the CABS-flex. CABS-flex was shown to be an efficient alternative to conventional all-atom molecular dynamics (MD). In this work, we evaluate CABS-flex and MD predictions by comparison with protein structural variations within NMR ensembles. Results: Based on a benchmark set of 140 proteins, we show that the relative fluctuations of protein residues obtained from CABS-flex are well correlated to those of NMR ensembles. On average, this correlation is stronger than that between MD and NMR ensembles. In conclusion, CABS-flex is useful and complementary to MD in predicting protein regions that undergo conformational changes as well as the extent of such changes. Availability and implementation: The CABS-flex is freely available to all users at http://biocomp.chem.uw.edu.pl/CABSflex. Contact: sekmi@chem.uw.edu.pl Supplementary information: Supplementary data are available at Bioinformatics online. PMID:24735558

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

PubMed Central

Blank, Birgit; Maiser, Andreas; Emin, Derya; Prescher, Jens; Beck, Gisela; Kienzle, Christine; Bartnik, Kira; Habermann, Bianca; Pakdel, Mehrshad; Leonhardt, Heinrich; Lamb, Don C.

2016-01-01

Sorting and export of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well understood. However, elucidation of the mechanism by which secretory cargoes are segregated for their release into the extracellular space remains a challenge. We have previously demonstrated that, in a reaction that requires Ca2+, the soluble TGN-resident protein Cab45 is necessary for the sorting of secretory cargoes at the TGN. Here, we report that Cab45 reversibly assembles into oligomers in the presence of Ca2+. These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca2+-dependent manner in vitro. In intact cells, mutation of the Ca2+-binding sites in Cab45 impairs oligomerization, as well as COMP and LyzC sorting. Superresolution microscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca2+ pump (SPCA1) in specific TGN microdomains. These findings reveal that Ca2+-dependent changes in Cab45 mediate sorting of specific cargo molecules at the TGN. PMID:27138253

CABS-flex predictions of protein flexibility compared with NMR ensembles.

PubMed

Jamroz, Michal; Kolinski, Andrzej; Kmiecik, Sebastian

2014-08-01

Identification of flexible regions of protein structures is important for understanding of their biological functions. Recently, we have developed a fast approach for predicting protein structure fluctuations from a single protein model: the CABS-flex. CABS-flex was shown to be an efficient alternative to conventional all-atom molecular dynamics (MD). In this work, we evaluate CABS-flex and MD predictions by comparison with protein structural variations within NMR ensembles. Based on a benchmark set of 140 proteins, we show that the relative fluctuations of protein residues obtained from CABS-flex are well correlated to those of NMR ensembles. On average, this correlation is stronger than that between MD and NMR ensembles. In conclusion, CABS-flex is useful and complementary to MD in predicting protein regions that undergo conformational changes as well as the extent of such changes. The CABS-flex is freely available to all users at http://biocomp.chem.uw.edu.pl/CABSflex. sekmi@chem.uw.edu.pl Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

Physical map location of the multicopy genes coding for ammonia monooxygenase and hydroxylamine oxidoreductase in the ammonia-oxidizing bacterium Nitrosomonas sp. strain ENI-11.

PubMed

Hirota, R; Yamagata, A; Kato, J; Kuroda, A; Ikeda, T; Takiguchi, N; Ohtake, H

2000-02-01

Pulsed-field gel electrophoresis of PmeI digests of the Nitrosomonas sp. strain ENI-11 chromosome produced four bands ranging from 1,200 to 480 kb in size. Southern hybridizations suggested that a 487-kb PmeI fragment contained two copies of the amoCAB genes, coding for ammonia monooxygenase (designated amoCAB(1) and amoCAB(2)), and three copies of the hao gene, coding for hydroxylamine oxidoreductase (hao(1), hao(2), and hao(3)). In this DNA fragment, amoCAB(1) and amoCAB(2) were about 390 kb apart, while hao(1), hao(2), and hao(3) were separated by at least about 100 kb from each other. Interestingly, hao(1) and hao(2) were located relatively close to amoCAB(1) and amoCAB(2), respectively. DNA sequence analysis revealed that hao(1) and hao(2) shared 160 identical nucleotides immediately upstream of each translation initiation codon. However, hao(3) showed only 30% nucleotide identity in the 160-bp corresponding region.

Physical Map Location of the Multicopy Genes Coding for Ammonia Monooxygenase and Hydroxylamine Oxidoreductase in the Ammonia-Oxidizing Bacterium Nitrosomonas sp. Strain ENI-11

PubMed Central

Hirota, Ryuichi; Yamagata, Akira; Kato, Junichi; Kuroda, Akio; Ikeda, Tsukasa; Takiguchi, Noboru; Ohtake, Hisao

2000-01-01

Pulsed-field gel electrophoresis of PmeI digests of the Nitrosomonas sp. strain ENI-11 chromosome produced four bands ranging from 1,200 to 480 kb in size. Southern hybridizations suggested that a 487-kb PmeI fragment contained two copies of the amoCAB genes, coding for ammonia monooxygenase (designated amoCAB1 and amoCAB2), and three copies of the hao gene, coding for hydroxylamine oxidoreductase (hao1, hao2, and hao3). In this DNA fragment, amoCAB1 and amoCAB2 were about 390 kb apart, while hao1, hao2, and hao3 were separated by at least about 100 kb from each other. Interestingly, hao1 and hao2 were located relatively close to amoCAB1 and amoCAB2, respectively. DNA sequence analysis revealed that hao1 and hao2 shared 160 identical nucleotides immediately upstream of each translation initiation codon. However, hao3 showed only 30% nucleotide identity in the 160-bp corresponding region. PMID:10633121

49 CFR 393.203 - Cab and body components.

Code of Federal Regulations, 2010 CFR

2010-10-01

... NECESSARY FOR SAFE OPERATION Frames, Cab and Body Components, Wheels, Steering, and Suspension Systems § 393... a roof exit. (b) Bolts or brackets securing the cab or the body of the vehicle to the frame shall...

From molecular salt to pseudo CAB cocrystal: Expanding solid-state landscape of carboxylic acids based on charge-assisted COOH⋯COO- hydrogen bonds

NASA Astrophysics Data System (ADS)

Lou, Benyong; Perumalla, Sathyanarayana Reddy; Sun, Changquan Calvin

2015-11-01

Using three carboxylic acids, we show that the COOH⋯COO- synthon is robust for directing the cocrystallization between a carboxylic acid and a carboxylate of either the same or a chemically different molecule to form a CAB or pseudo CAB cocrystal, respectively. For a given carboxylic acid and a counterion, only one salt could be prepared. However, additional one CAB cocrystals and two pseudo CAB cocrystals could be prepared based on the COOH⋯COO- synthon. The same synthon has the potential to enable the preparation of additional molecular pseudo CAB cocrystals using other chemically distinct carboxylic acids. This significantly increased number of solid forms highlights the values of charge-assisted synthons, such as COOH⋯COO-, in crystal engineering for expanding the range of material properties of a given molecule for optimum performance in product design.

Evaluation of the driver's cab in the Rc5 engine.

PubMed

Hedberg, G

1987-03-01

The opinion of engine drivers concerning the design of the cab in a new engine (Rc5, ASEA, Sweden) is surveyed in the present study, which is aimed at recommendations for further improvements of the new cab. Fifty engine drivers from the northern part of Sweden (Ange, Vannas and Boden), who had been driving the new engine, were selected at random to answer a specially designed questionnaire. Most of the drivers considered the new cab as better than the old one (Rc4) in several respects. Particularly appreciated was an adjustable footrest, on which the safety regulator pedal was fitted, which enabled an individually adjusted position for driving. They also preferred the automatic brake valve located close to the driver and with its movements in a sagittal direction. A number of proposals for further improvement of the cab are presented in order to attain an optimally designed driver's cab.

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

PubMed Central

Bylsma, Lauren M.; Yaroslavsky, Ilya; Rottenberg, Jonathan; Jennings, J. Richard; George, Charles J.; Kiss, Enikő; Kapornai, Krisztina; Halas, Kitti; Dochnal, Roberta; Lefkovics, Eszter; Benák, István; Baji, Ildikó; Vetró, Ágnes; Kovacs, Maria

2015-01-01

Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation (Berntson, Norman, Hawkley, & Cacioppo, 2008), and is believed to reflect overall autonomic flexibility in the face of environmental challenges. However, CAB has not been examined in depression. We examined changes in CAB and other physiological variables in 179 youth with a history of juvenile onset depression (JOD) and 161 healthy controls, in response to two psychological (unsolvable puzzle, sad film) and two physical (handgrip, and forehead cold pressor) challenges. In repeated measures analyses, controls showed expected reductions in CAB for both the handgrip and unsolvable puzzle, reflecting a shift to sympathetic relative to parasympathetic activation. By contrast, JOD youth showed increased CAB from baseline for both tasks (ps<.05). No effects were found for the forehead cold pressor or sad film tasks, suggesting that CAB differences may arise under conditions requiring greater attentional control or sustained effort. PMID:26225465

Constraining ecosystem processes from tower fluxes and atmospheric profiles.

PubMed

Hill, T C; Williams, M; Woodward, F I; Moncrieff, J B

2011-07-01

The planetary boundary layer (PBL) provides an important link between the scales and processes resolved by global atmospheric sampling/modeling and site-based flux measurements. The PBL is in direct contact with the land surface, both driving and responding to ecosystem processes. Measurements within the PBL (e.g., by radiosondes, aircraft profiles, and flask measurements) have a footprint, and thus an integrating scale, on the order of 1-100 km. We use the coupled atmosphere-biosphere model (CAB) and a Bayesian data assimilation framework to investigate the amount of biosphere process information that can be inferred from PBL measurements. We investigate the information content of PBL measurements in a two-stage study. First, we demonstrate consistency between the coupled model (CAB) and measurements, by comparing the model to eddy covariance flux tower measurements (i.e., water and carbon fluxes) and also PBL scalar profile measurements (i.e., water, carbon dioxide, and temperature) from Canadian boreal forest. Second, we use the CAB model in a set of Bayesian inversions experiments using synthetic data for a single day. In the synthetic experiment, leaf area and respiration were relatively well constrained, whereas surface albedo and plant hydraulic conductance were only moderately constrained. Finally, the abilities of the PBL profiles and the eddy covariance data to constrain the parameters were largely similar and only slightly lower than the combination of both observations.

Locomotive crashworthiness research : volume 5 : cab car crashworthiness report

DOT National Transportation Integrated Search

1996-03-01

Models used to analyze locomotive crashworthiness are modified for application to control cab cars of the types used for intercity and commuter rail passenger service. An existing control cab car is analyzed for crashworthiness based on scenarios dev...

Atlanta Tower Cab and TRACON Equipment Integration Analysis

DOT National Transportation Integrated Search

1980-10-01

This report presents an analysis of how the new Terminal Information Processing System (TIPS) and Consolidated Cab Display (CCD) equipments might appear to Air Traffic personnel if they were installed in the tower cab and TRACON at Hartsfield-Atlanta...

ARC-1997-AC97-0295-14

NASA Image and Video Library

1997-09-03

N-257 CVSRF: control rooms for 747 and ACSF cabs - LEFT SIDE; EOS - ACFS (Advanced Cab Flight Simulator) w. (l-r) Victor Loesche, Hector Reyes & Eric Jacobs and RIGHT SIDE; EOS - 747 Cab with (l-r) David Brown and Cindy Nguyen

16 CFR 700.8 - Warrantor's decision as final.

Code of Federal Regulations, 2010 CFR

2010-01-01

... jurisdiction over suits for breach of warranty and service contract. ... decision as final. A warrantor shall not indicate in any written warranty or service contract either... party is final or binding in any dispute concerning the warranty or service contract. Nor shall a...

Quantifying the foodscape: A systematic review and meta-analysis of the validity of commercially available business data.

PubMed

Lebel, Alexandre; Daepp, Madeleine I G; Block, Jason P; Walker, Renée; Lalonde, Benoît; Kestens, Yan; Subramanian, S V

2017-01-01

This paper reviews studies of the validity of commercially available business (CAB) data on food establishments ("the foodscape"), offering a meta-analysis of characteristics associated with CAB quality and a case study evaluating the performance of commonly-used validity indicators describing the foodscape. Existing validation studies report a broad range in CAB data quality, although most studies conclude that CAB quality is "moderate" to "substantial". We conclude that current studies may underestimate the quality of CAB data. We recommend that future validation studies use density-adjusted and exposure measures to offer a more meaningful characterization of the relationship of data error with spatial exposure.

Quantifying the foodscape: A systematic review and meta-analysis of the validity of commercially available business data

PubMed Central

Lebel, Alexandre; Daepp, Madeleine I. G.; Block, Jason P.; Walker, Renée; Lalonde, Benoît; Kestens, Yan; Subramanian, S. V.

2017-01-01

This paper reviews studies of the validity of commercially available business (CAB) data on food establishments (“the foodscape”), offering a meta-analysis of characteristics associated with CAB quality and a case study evaluating the performance of commonly-used validity indicators describing the foodscape. Existing validation studies report a broad range in CAB data quality, although most studies conclude that CAB quality is “moderate” to “substantial”. We conclude that current studies may underestimate the quality of CAB data. We recommend that future validation studies use density-adjusted and exposure measures to offer a more meaningful characterization of the relationship of data error with spatial exposure. PMID:28358819

Country analysis briefs: 1994. Profiles of major world energy producers, consumers, and transport centers

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-01

Country Analysis Briefs: 1994 is a compilation of country profiles prepared by the Energy Markets and Contingency Information Division (EMCID) of the Office of Energy Markets and End Use. EMCID maintains Country Analysis Briefs (CABs) for specific countries or geographical areas that are important to world energy markets. As a general rule, CABs are prepared for all members of the Organization of Petroleum Exporting Countries (OPEC), major non-OPEC oil producers (i.e., the North Sea, Russia), major energy transit areas (i.e., Ukraine), and other areas of current interest to energy analysts and policy makers. As of January 1995, EMCID maintained overmore » 40 CABs, updated on an annual schedule and subject to revision as events warrant. This report includes 25 CABs updated during 1994. All CABs contain a profile section, a map showing the country`s location, and a narrative section. The profile section includes outlines of the country`s economy, energy sector, and environment. The narrative provides further information and discussion of these topics. Some CABs also include a detailed map displaying locations of major oil and gas fields, pipelines, ports, etc. These maps were created as a result of special individual requests and so are not typically a standard feature of the CABs. They are presented here wherever available as a supplement to the information contained in the CABs.« less

Human Factors Guidelines for the Evaluation of the Locomotive Cab

DOT National Transportation Integrated Search

1995-09-01

This document presents human factors guidelines for the evaluation of the locomotive cab. These guidelines are part of : an effort to evaluate working conditions and safety in the locomotive cab. The guidelines will serve as a decision : making tool ...

Executive Summary : Tower Cab System Integration Analysis

DOT National Transportation Integrated Search

1978-08-01

This report summarizes the principal results of the study of the integration into the tower cab of the systems being developed under the Major Systems Development Program (MSDP). The impact of these systems on the tower cab is analyzed from several p...

78 FR 66639 - Modifications of Certain Derivative Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-06

... Modifications of Certain Derivative Contracts AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final... to the transfer or assignment of certain derivative contracts. The final regulations provide guidance to the nonassigning counterparty to a derivative contract and an assignee on certain notional...

Plasma endotoxin core antibody concentration and linear growth are unrelated in rural Malawian children aged 2-5 years.

PubMed

Benzoni, Nicole; Korpe, Poonum; Thakwalakwa, Chrissie; Maleta, Ken; Stephenson, Kevin; Manary, Micah; Manary, Mark

2015-06-24

Environmental enteropathy is subclinical inflammation of the upper gastrointestinal tract associated with reduced linear growth in developing countries. Usually investigators have used biopsy or a dual sugar absorption test to assess environmental enteropathy. Such tests are time and resource intensive, restricting their utility as screening methods. Serum endotoxin core antibody (EndoCab) concentration is a potential indicator of intestinal inflammation and integrity, and thus may be useful to predict environmental enteropathy. We analyzed the association of serum EndoCab levels versus linear growth and lactulose-mannitol assay results in 2-5 year old rural Malawian children. This was an observational study of 388 rural, asymptomatic Malawian children who had anthropometric measurements taken at least every 3 months since birth. In June and July 2011, dual sugar permeability tests were performed and serum samples were drawn for EndoCab assays. Pearson correlation, Student's t test and multivariable linear regression were used to compare ln EndoCab concentrations with height-for-age z scores (HAZ) at time of sampling and 3 months later. Identical analysis was also performed for ln EndoCab versus measurements from dual sugar permeability testing performed in conjunction with serum sampling. In a subgroup of children with anthropometric data in the months prior to serum sampling, Pearson correlation was used to estimate the relationship between ln EndoCab and recent linear growth. Ln EndoCab concentrations were not correlated with HAZ at time of measurement (B = -0.078, P = 0.14) nor change in HAZ over the subsequent 3 months HAZ (B = -0.018, P = 0.27). EndoCab concentration was not associated with %lactulose excretion (B < 0.001, P = 0.98) nor the lactulose:mannitol ratio (B = 0.021, P = 0.62). Subgroup analysis also did not reveal any significant association between EndoCab and recent growth. EndoCab titers were not correlated with measurements of growth or intestinal permeability in rural pre-school aged Malawian children.

Establishment of a Community Advisory Board (CAB) for tuberculosis control and research in the Inanda, Ntuzuma and KwaMashu (INK) area of KwaZulu-Natal, South Africa.

PubMed

Ntshanga, Sbongile P; Ngcobo, Paulos S; Mabaso, Musawenkosi L H

2010-05-01

To strengthen community mobilization, education, awareness and involvement in research to improve Tuberculosis (TB) control, by building partnership between communities and the health sector through the establishment of a Community Advisory Board (CAB) in the Inanda, Ntuzuma and KwaMashu (INK) area. Key stakeholders from multiple sectors of the target community were identified. Two workshops were held with the aim of communicating the need for CAB and selecting its members. A 22 member INK CAB with representatives from different sectors in the community was selected. CAB members were trained through a 2-day workshop on TB and research. Various activities were successfully initiated and spearheaded by the INK CAB, and these involved training of Traditional Healers, recruiting of more TB tracer teams, organizing awareness campaigns during TB World Day, establishing TB school peer educators and links with NGOs to support impoverished TB patients all with positive outcomes. The INK CAB is a successful example of providing a mechanism for community consultation and participation that contributes to promoting and facilitating relevant research and TB control activities. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

In-vitro dissolution rate and molecular docking studies of cabergoline drug with β-cyclodextrin

NASA Astrophysics Data System (ADS)

Shanmuga priya, Arumugam; Balakrishnan, Suganya bharathi; Veerakanellore, Giri Babu; Stalin, Thambusamy

2018-05-01

The physicochemical properties and dissolution profile of cabergoline drug (CAB) with β-cyclodextrin (β-CD) inclusion complex were investigated by the UV spectroscopy. The inclusion complex has used to calculate the stability constant and gives the stoichiometry molar ratio is 1:1 between CAB and β-CD. The phase solubility diagram and the aqueous solubility of CAB (60%) was found to be enhanced by β-CD. In addition, the phase solubility profile of CAB with β-CD was classified as AL-type. Binary systems of CAB with β-CD were prepared by Physical mixture, Kneading and solvent evaporation methods. The solid-state properties of the inclusion complex were characterized by Fourier transformation-infrared spectroscopy, Differential scanning calorimetry, Powder X-ray diffractometric patterns and Scanning electron microscopic techniques. Theoretically, β-CD and CAB inclusion complex obtained by molecular docking studies, it is in good correlation with the results obtained through experimental methods using the Schrödinger software program. In-vitro dissolution profiles of the inclusion complexes were carried out and obvious increase in dissolution rate was observed when compared with pure CAB drug and the complexes.

Systems Integration Analysis for Future Tower Cab Configurations/Systems

DOT National Transportation Integrated Search

1978-06-01

This report presents the results of the analysis of various aspects of the integration of future ATC systems into the tower cab. The impact on the tower cab environment is analyzed from several points of view: how the systems information and displays...

Selection of the Next Generation of Air Traffic Control Specialists: Aptitude Requirements for the Air Traffic Control Tower Cab in 2018

DTIC Science & Technology

2013-03-01

Sequencing; and 5) Taxi Routing (with Conformance Monitoring). Third, the impact of these DSTs on tower cab operational activities, sub-activities...keystroke or interface level. Fourth, the impact of the DSTs on aptitudes required of controllers is evaluated. The importance of the following aptitudes...Analysis of Mid-Term NextGen Impact on Aptitudes Required in the ATCT Cab ---------------- 36 Mid-Term DST Impact on Tower Cab Controller Roles

Cloning and characterization of a calcium binding EF-hand protein gene TaCab1 from wheat and its expression in response to Puccinia striiformis f. sp. tritici and abiotic stresses.

PubMed

Feng, Hao; Wang, Xiaomin; Sun, Yanfei; Wang, Xiaojie; Chen, Xianming; Guo, Jun; Duan, Yinghui; Huang, Lili; Kang, Zhensheng

2011-08-01

Calcium is a ubiquitous and essential secondary messenger in eukaryotic signal transduction pathways. Calcium binding protein, as a component of pathways, plays various roles in response to biotic and abiotic stresses, as well as in developmental processes in plants. In this study, a calcium binding protein gene, designated as TaCab1 (Triticum aestivum calcium binding EF-hand protein 1), was isolated and characterized from wheat leaves (cv. Suwon 11) infected by Puccinia striiformis f. sp. tritici by in silico cloning and reverse transcription PCR (RT-PCR). TaCab1 did not have an intron and was predicted to encode a 216 amino acid protein which possesses an N-terminal region with a signal peptide, a transmembrane domain, an EF-hand motif and a caleosin domain. The results of transient assays with constructs of TaCab1 with green fluorescent protein (GFP) gene indicated that TaCab1 encodes a transmembrane protein. Quantitative real-time PCR (qRT-PCR) analyses revealed that TaCab1 was highly expressed in leaves than roots and stems. Although up-regulated expression profiles of TaCab1 were quite similar in both incompatible and compatible interactions, its transcript accumulation in the compatible interaction was much higher than in the incompatible interaction. The transcription of TaCab1 was also up-regulated at different degrees after treated by phytohormones [abscisic acid, benzyl adenine, ethylene, methyl jasmonate and salicylic acid (SA)] and stress stimuli [wounding, low temperature, polyethylene glycol and high salinity]. These results suggest that TaCab1 is involved in the plant-pathogen recognition, symptom development, and the basal tolerance to biotic and abiotic stresses through the SA signaling pathway.

Taxi Cab Syndrome: A Review of the Extensive Genitourinary Pathology Experienced by Taxi Cab Drivers and What We Can Do to Help

PubMed Central

Mass, Alon Y; Goldfarb, David S; Shah, Ojas

2014-01-01

This review consolidates knowledge regarding the extensive genitourinary pathology experienced by taxi cab drivers. Taxi cab, livery, truck, and other drivers all objectively and subjectively may have more voiding dysfunction, infertility, urolithiasis, bladder cancer, and urinary infections as compared with nonprofessional drivers; this is called taxi cab syndrome. Together with governmental and medical assistance, simple interventions—such as education, the addition of taxi relief stations, and possibly the use of sanitary urinary collection devices—to curb the progression of genitourinary disease in taxi drivers should be prospectively studied. It is postulated that many of these interventions may also benefit other groups of occupationally related infrequent voiders. PMID:25337038

49 CFR 230.81 - Cab aprons.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Cab aprons. 230.81 Section 230.81 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and Tenders Cabs, Warning Signals, Sanders and Lights §...

Coarse-Grained Simulations of Membrane Insertion and Folding of Small Helical Proteins Using the CABS Model.

PubMed

Pulawski, Wojciech; Jamroz, Michal; Kolinski, Michal; Kolinski, Andrzej; Kmiecik, Sebastian

2016-11-28

The CABS coarse-grained model is a well-established tool for modeling globular proteins (predicting their structure, dynamics, and interactions). Here we introduce an extension of the CABS representation and force field (CABS-membrane) to the modeling of the effect of the biological membrane environment on the structure of membrane proteins. We validate the CABS-membrane model in folding simulations of 10 short helical membrane proteins not using any knowledge about their structure. The simulations start from random protein conformations placed outside the membrane environment and allow for full flexibility of the modeled proteins during their spontaneous insertion into the membrane. In the resulting trajectories, we have found models close to the experimental membrane structures. We also attempted to select the correctly folded models using simple filtering followed by structural clustering combined with reconstruction to the all-atom representation and all-atom scoring. The CABS-membrane model is a promising approach for further development toward modeling of large protein-membrane systems.

49 CFR 236.513 - Audible indicator.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.513 Audible indicator. (a) The automatic cab signal... control system shall have a distinctive sound and be clearly audible throughout the cab under all...

49 CFR 236.513 - Audible indicator.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.513 Audible indicator. (a) The automatic cab signal... control system shall have a distinctive sound and be clearly audible throughout the cab under all...

Prototype design of a collision protection system for cab car engineers.

DOT National Transportation Integrated Search

2013-03-01

The objective of this project was to develop and analyze a passive system to protect a cab car engineer from secondary impact injuries that might be experienced due to impact with the cab console. The primary requirement for the system was the abilit...

Avoiding the Health Hazard of People from Construction Vehicles: A Strategy for Controlling the Vibration of a Wheel Loader

PubMed Central

Chi, Feng; Zhou, Jun; Zhang, Qi; Wang, Yong; Huang, Panling

2017-01-01

The vibration control of a construction vehicle must be carried out in order to meet the aims of sustainable environmental development and to avoid the potential human health hazards. In this paper, based on market feedback, the driver seat vibration of a type of wheel loader in the left and right direction, is found to be significant over a certain speed range. In order to find abnormal vibration components, the order tracking technique (OTT) and transmission path analysis (TPA) were used to analyze the vibration sources of the wheel loader. Through this analysis, it can be seen that the abnormal vibration comes from the interaction between the tire tread and the road, and this is because the vibration was amplified by the cab mount, which was eventually transmitted to the cab seat. Finally, the seat vibration amplitudes were decreased by up to 50.8%, after implementing the vibration reduction strategy. PMID:28282849

Avoiding the Health Hazard of People from Construction Vehicles: A Strategy for Controlling the Vibration of a Wheel Loader.

PubMed

Chi, Feng; Zhou, Jun; Zhang, Qi; Wang, Yong; Huang, Panling

2017-03-08

The vibration control of a construction vehicle must be carried out in order to meet the aims of sustainable environmental development and to avoid the potential human health hazards. In this paper, based on market feedback, the driver seat vibration of a type of wheel loader in the left and right direction, is found to be significant over a certain speed range. In order to find abnormal vibration components, the order tracking technique (OTT) and transmission path analysis (TPA) were used to analyze the vibration sources of the wheel loader. Through this analysis, it can be seen that the abnormal vibration comes from the interaction between the tire tread and the road, and this is because the vibration was amplified by the cab mount, which was eventually transmitted to the cab seat. Finally, the seat vibration amplitudes were decreased by up to 50.8%, after implementing the vibration reduction strategy.

Final Report on the Audit of the Administration of the Contract Closeout Process at the Defense Contract Management Region, Dallas

DTIC Science & Technology

1990-09-18

This is our final report on the Audit of the Administration of the Contract Closeout Process at the Defense Contract Management Region, Dallas (DCMR... audit was made from January to October 1989. The objectives of the audit were to determine the timeliness of the contract closeout process, the validity...As part of the audit , we also evaluated internal controls over the contract closeout process. As of December 31, 1988, the Contract Administration

Analysis of colliding vehicle interactions for the passenger rail train-to-train impact test

DOT National Transportation Integrated Search

2004-04-06

A full-scale train-to-train impact test was performed in : which a cab car-led passenger train traveling at 30 mph collided : with a standing locomotive-led train. During the test, the lead : cab car overrode the cab of the standing locomotive, susta...

77 FR 32594 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... Advisors). The Bureau seeks to collect selection-related information from nominees to the CAB, such as... for other Advisory Groups, members of other Advisory Groups, and Special Advisors to CAB and other... obtain information on the qualifications of individuals nominated to the CAB and will aid the Bureau in...

49 CFR 229.121 - Locomotive cab noise.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Locomotive cab noise. 229.121 Section 229.121... § 229.121 Locomotive cab noise. (a) Performance standards for locomotives. (1) When tested for static noise in accordance with paragraph (a)(3) of this section, all locomotives of each design or model that...

49 CFR 235.5 - Changes requiring filing of application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... system, automatic train stop, train control, or cab signal system or other similar appliance or device..., automatic train stop, train control, or cab signal system; or (3) The modification of a block signal system, interlocking, traffic control system, automatic train stop, train control, or cab signal system. (b) [Reserved...

49 CFR 235.5 - Changes requiring filing of application.

Code of Federal Regulations, 2011 CFR

2011-10-01

... system, automatic train stop, train control, or cab signal system or other similar appliance or device..., automatic train stop, train control, or cab signal system; or (3) The modification of a block signal system, interlocking, traffic control system, automatic train stop, train control, or cab signal system. (b) [Reserved...

A crush zone design for an existing passenger rail cab car

DOT National Transportation Integrated Search

2005-11-05

A Crash Energy Management (CEM) cab car crush zone : design has been developed for retrofit onto an existing Budd : M1 cab car. This design is to be used in the upcoming fullscale : train-to-train test of a CEM consist impacting a standing : freight ...

Promising evidence of impact on road safety by changing at-risk behavior process at Union Pacific

DOT National Transportation Integrated Search

2008-06-01

Changing At-risk Behavior (CAB) is a safety process that is being conducted at Union Pacifics San Antonio Service Unit with the aim of improving locomotive cab safety related to constraining signals. CAB is an example of a risk reduction method th...

Passenger cab car grade crossing impact test report : rail passenger equipment impact tests

DOT National Transportation Integrated Search

2007-10-01

Two full-scale oblique grade crossing impact tests were conducted in June 2002 to compare the crashworthiness performance of alternative corner post designs on rail passenger cab cars. On June 4, 2002, a cab car fitted with an end frame built to pre-...

CABS-flex: server for fast simulation of protein structure fluctuations

PubMed Central

Jamroz, Michal; Kolinski, Andrzej; Kmiecik, Sebastian

2013-01-01

The CABS-flex server (http://biocomp.chem.uw.edu.pl/CABSflex) implements CABS-model–based protocol for the fast simulations of near-native dynamics of globular proteins. In this application, the CABS model was shown to be a computationally efficient alternative to all-atom molecular dynamics—a classical simulation approach. The simulation method has been validated on a large set of molecular dynamics simulation data. Using a single input (user-provided file in PDB format), the CABS-flex server outputs an ensemble of protein models (in all-atom PDB format) reflecting the flexibility of the input structure, together with the accompanying analysis (residue mean-square-fluctuation profile and others). The ensemble of predicted models can be used in structure-based studies of protein functions and interactions. PMID:23658222

CABS-flex: Server for fast simulation of protein structure fluctuations.

PubMed

Jamroz, Michal; Kolinski, Andrzej; Kmiecik, Sebastian

2013-07-01

The CABS-flex server (http://biocomp.chem.uw.edu.pl/CABSflex) implements CABS-model-based protocol for the fast simulations of near-native dynamics of globular proteins. In this application, the CABS model was shown to be a computationally efficient alternative to all-atom molecular dynamics--a classical simulation approach. The simulation method has been validated on a large set of molecular dynamics simulation data. Using a single input (user-provided file in PDB format), the CABS-flex server outputs an ensemble of protein models (in all-atom PDB format) reflecting the flexibility of the input structure, together with the accompanying analysis (residue mean-square-fluctuation profile and others). The ensemble of predicted models can be used in structure-based studies of protein functions and interactions.

Material decomposition images generated from spectral CT: detectability of urinary calculi and influencing factors.

PubMed

Lv, Peijie; Zhang, Yonggao; Liu, Jie; Ji, Lijuan; Chen, Yan; Gao, Jianbo

2014-01-01

To evaluate the detectability of urinary calculi on material decomposition (MD) images generated from spectral computed tomography (CT) and identify the influencing factors. Forty-six patients were examined with true nonenhanced (TNE) CT and spectral CT urography in the excretory phase. The contrast medium was removed from excretory phase images using water-based (WB) and calcium-based (CaB) MD analysis. The sensitivity for detection on WB and CaB images was evaluated using TNE results as the reference standard. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) on MD images were evaluated. Using logistic regression, the influences of image noise, attenuation, stone size, and patient's body mass index (BMI) were assessed. Threshold values with maximal sensitivity and specificity were calculated by means of receiver operating characteristic analyses. One hundred thirty-six calculi were detected on TNE images; 98 calculi were identified on WB images (sensitivity, 72.06%) and 101 calculi on CaB images (sensitivity, 74.26%). Sensitivities were 76.92% for the 3-5-mm stones and 84.51% for the 5-mm or larger stones on both WB and CaB images but reduced to 46.15% on WB images and 53.85% on CaB images for small calculi (<3 mm). Compared to WB images, CaB images showed lower image noise, higher SNR but similar CNR. Larger stone sizes (both >2.71 mm on WB and CaB) and greater CT attenuation (>280 Hounsfield units [HU] on WB, >215 HU on CaB) of the urinary stones were significantly associated with higher stone visibility rates on WB and CaB images (P ≤ .003). Image noise and BMI showed no impact on the stone detection. MD images generated from spectral CT showed good reliability for the detection of large (>2.71 mm) and hyperattenuating (>280 HU on WB, >215 HU on CaB) urinary calculi. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

ABC versus CAB for cardiopulmonary resuscitation: a prospective, randomized simulator-based trial.

PubMed

Marsch, Stephan; Tschan, Franziska; Semmer, Norbert K; Zobrist, Roger; Hunziker, Patrick R; Hunziker, Sabina

2013-09-06

After years of advocating ABC (Airway-Breathing-Circulation), current guidelines of cardiopulmonary resuscitation (CPR) recommend CAB (Circulation-Airway-Breathing). This trial compared ABC with CAB as initial approach to CPR from the arrival of rescuers until the completion of the first resuscitation cycle. 108 teams, consisting of two physicians each, were randomized to receive a graphical display of either the ABC algorithm or the CAB algorithm. Subsequently teams had to treat a simulated cardiac arrest. Data analysis was performed using video recordings obtained during simulations. The primary endpoint was the time to completion of the first resuscitation cycle of 30 compressions and two ventilations. The time to execution of the first resuscitation measure was 32 ± 12 seconds in ABC teams and 25 ± 10 seconds in CAB teams (P = 0.002). 18/53 ABC teams (34%) and none of the 55 CAB teams (P = 0.006) applied more than the recommended two initial rescue breaths which caused a longer duration of the first cycle of 30 compressions and two ventilations in ABC teams (31 ± 13 vs.23 ± 6 sec; P = 0.001). Overall, the time to completion of the first resuscitation cycle was longer in ABC teams (63 ± 17 vs. 48 ± 10 sec; P <0.0001). This randomized controlled trial found CAB superior to ABC with an earlier start of CPR and a shorter time to completion of the first 30:2 resuscitation cycle. These findings endorse the change from ABC to CAB in international resuscitation guidelines.

30 CFR 75.1710 - Canopies or cabs; diesel-powered and electric face equipment.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-powered and electric face equipment, including shuttle cars, be provided with substantially constructed... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Canopies or cabs; diesel-powered and electric... Miscellaneous § 75.1710 Canopies or cabs; diesel-powered and electric face equipment. In any coal mine where the...

30 CFR 75.1710 - Canopies or cabs; diesel-powered and electric face equipment.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-powered and electric face equipment, including shuttle cars, be provided with substantially constructed... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Canopies or cabs; diesel-powered and electric... Miscellaneous § 75.1710 Canopies or cabs; diesel-powered and electric face equipment. In any coal mine where the...

30 CFR 75.1710 - Canopies or cabs; diesel-powered and electric face equipment.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-powered and electric face equipment, including shuttle cars, be provided with substantially constructed... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Canopies or cabs; diesel-powered and electric... Miscellaneous § 75.1710 Canopies or cabs; diesel-powered and electric face equipment. In any coal mine where the...

30 CFR 75.1710 - Canopies or cabs; diesel-powered and electric face equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-powered and electric face equipment, including shuttle cars, be provided with substantially constructed... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Canopies or cabs; diesel-powered and electric... Miscellaneous § 75.1710 Canopies or cabs; diesel-powered and electric face equipment. In any coal mine where the...

30 CFR 75.1710 - Canopies or cabs; diesel-powered and electric face equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-powered and electric face equipment, including shuttle cars, be provided with substantially constructed... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Canopies or cabs; diesel-powered and electric... Miscellaneous § 75.1710 Canopies or cabs; diesel-powered and electric face equipment. In any coal mine where the...

49 CFR 223.11 - Requirements for existing locomotives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... be equipped with certified glazing in all locomotive cab windows after June 30, 1984. (d) Each... vandalism has a locomotive cab window that is broken or damaged so that the window fails to permit good... broken or damaged window is a part of the windshield of the locomotive cab, all of the forward and...

Mechanical and thermal properties of eco-friendly poly(propylene carbonate)/cellulose acetate butyrate blends.

PubMed

Xing, Chenyang; Wang, Hengti; Hu, Qiaoqiao; Xu, Fenfen; Cao, Xiaojun; You, Jichun; Li, Yongjin

2013-02-15

The eco-friendly poly(propylene carbonate) (PPC)/cellulose acetate butyrate (CAB) blends were prepared by melt-blending in a batch mixer for the first time. PPC and CAB were partially miscible because of the drastically shifted glass transition temperatures of both PPC and CAB, which originated from the specific interactions between carbonyl groups and hydroxyl groups. The incorporation of CAB into PPC matrix enhanced not only tensile strength and modulus of PPC dramatically, but also improved heat resistance and thermal stability of PPC significantly. The tensile strength and the modulus of PPC/CAB=50/50 blend are 27.7 MPa and 1.24 GPa, which are 21 times and 28 times higher than those of the unmodified PPC, respectively. Moreover, the elongation at break of PPC/CAB=50/50 blend is as high as 117%. In addition, the obtained blends exhibited good transparency, which is very important for the package materials. The results in this work pave new possibility for the massive application of eco-friendly polymer materials. Copyright © 2012 Elsevier Ltd. All rights reserved.

Effects of MERV 16 filters and routine work practices on enclosed cabs for reducing respirable dust and DPM exposures in an underground limestone mine

PubMed Central

Noll, J.D.; Cecala, A.B.; J.A.Organiscak; Rider, J.P.

2015-01-01

An effective technique to minimize miners’ respirable dust and diesel exposure on mobile mining equipment is to place mine operators in enclosed cabs with designed filtration and pressurization systems. Many factors affect the performance of these enclosed cab systems, and one of the most significant factors is the effectiveness of the filtration system. High-efficiency particulate air (HEPA)-type filters are typically used because they are highly efficient at capturing all types and sizes of particles, including those in the submicron range such as diesel particulate matter (DPM). However, in laboratory tests, minimum efficiency reporting value (MERV) 16 filters have proven to be highly efficient for capturing DPM and respirable dust. Also, MERV 16 filters can be less restrictive to cab airflow and less expensive than HEPA filters. To verify their effectiveness in the field, MERV 16 filters were used in the enclosed cab filtration system on a face drill and roof bolting mining machine and tested at an underground limestone mine. Test results showed that DPM and respirable dust concentrations were reduced by more than 90% when the cabs were properly sealed. However, when the cab door was opened periodically throughout the shift, the reduction efficiency of the MERV 16 filters was reduced to 80% on average. PMID:26236044

49 CFR 236.511 - Cab signals controlled in accordance with block conditions stopping distance in advance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Cab signals controlled in accordance with block conditions stopping distance in advance. 236.511 Section 236.511 Transportation Other Regulations Relating to... § 236.511 Cab signals controlled in accordance with block conditions stopping distance in advance. The...

49 CFR 236.566 - Locomotive of each train operating in train stop, train control or cab signal territory; equipped.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and... controlled, of each train operating in automatic train stop, train control, or cab signal territory shall be..., train control or cab signal territory; equipped. 236.566 Section 236.566 Transportation Other...

49 CFR 236.566 - Locomotive of each train operating in train stop, train control or cab signal territory; equipped.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and... controlled, of each train operating in automatic train stop, train control, or cab signal territory shall be..., train control or cab signal territory; equipped. 236.566 Section 236.566 Transportation Other...

49 CFR 236.568 - Difference between speeds authorized by roadway signal and cab signal; action required.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Difference between speeds authorized by roadway... Systems Rules and Instructions; Locomotives § 236.568 Difference between speeds authorized by roadway signal and cab signal; action required. If for any reason a cab signal authorizes a speed different from...

49 CFR 236.568 - Difference between speeds authorized by roadway signal and cab signal; action required.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Difference between speeds authorized by roadway... Systems Rules and Instructions; Locomotives § 236.568 Difference between speeds authorized by roadway signal and cab signal; action required. If for any reason a cab signal authorizes a speed different from...

A novel biomarker associated with distress in humans: calcium-binding protein, spermatid-specific 1 (CABS1)

PubMed Central

Ritz, Thomas; Rosenfield, David; St. Laurent, Chris D.; Trueba, Ana F.; Werchan, Chelsey A.; Vogel, Pia D.; Auchus, Richard J.; Reyes-Serratos, Eduardo

2017-01-01

Calcium-binding protein spermatid-specific 1 (CABS1) is expressed in the human submandibular gland and has an anti-inflammatory motif similar to that in submandibular rat 1 in rats. Here, we investigate CABS1 in human saliva and its association with psychological and physiological distress and inflammation in humans. Volunteers participated across three studies: 1) weekly baseline measures; 2) a psychosocial speech and mental arithmetic stressor under evaluative threat; and 3) during academic exam stress. Salivary samples were analyzed for CABS1 and cortisol. Additional measures included questionnaires of perceived stress and negative affect; exhaled nitric oxide; respiration and cardiac activity; lung function; and salivary and nasal inflammatory markers. We identified a CABS1 immunoreactive band at 27 kDa in all participants and additional molecular mass forms in some participants. One week temporal stability of the 27-kDa band was satisfactory (test–retest reliability estimate = 0.62–0.86). Acute stress increased intensity of 18, 27, and 55 kDa bands; 27-kDa increases were associated with more negative affect and lower heart rate, sympathetic activity, respiration rate, and minute ventilation. In both acute and academic stress, changes in 27 kDa were positively associated with salivary cortisol. The 27-kDa band was also positively associated with VEGF and salivary leukotriene B4 levels. Participants with low molecular weight CABS1 bands showed reduced habitual stress and negative affect in response to acute stress. CABS1 is readily detected in human saliva and is associated with psychological and physiological indicators of stress. The role of CABS1 in inflammatory processes, stress, and stress resilience requires careful study. PMID:28381457

Epidemiology, microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study.

PubMed

Kanoksil, Manas; Jatapai, Anchalee; Peacock, Sharon J; Limmathurotsakul, Direk

2013-01-01

National statistics in developing countries are likely to underestimate deaths due to bacterial infections. Here, we calculated mortality associated with community-acquired bacteremia (CAB) in a developing country using routinely available databases. Information was obtained from the microbiology and hospital database of 10 provincial hospitals in northeast Thailand, and compared with the national death registry from the Ministry of Interior, Thailand for the period between 2004 and 2010. CAB was defined in patients who had pathogenic organisms isolated from blood taken within 2 days of hospital admission without a prior inpatient episode in the preceding 30 days. A total of 15,251 CAB patients identified, of which 5,722 (37.5%) died within 30 days of admission. The incidence rate of CAB between 2004 and 2010 increased from 16.7 to 38.1 per 100,000 people per year, and the mortality rate associated with CAB increased from 6.9 to 13.7 per 100,000 people per year. In 2010, the mortality rate associated with CAB was lower than that from respiratory tract infection, but higher than HIV disease or tuberculosis. The most common causes of CAB were Escherichia coli (23.1%), Burkholderia pseudomallei (19.3%), and Staphylococcus aureus (8.2%). There was an increase in the proportion of Extended-Spectrum Beta-Lactamases (ESBL) producing E. coli and Klebsiella pneumoniae over time. This study has demonstrated that national statistics on causes of death in developing countries could be improved by integrating information from readily available databases. CAB is neglected as an important cause of death, and specific prevention and intervention is urgently required to reduce its incidence and mortality.

Epidemiology, Microbiology and Mortality Associated with Community-Acquired Bacteremia in Northeast Thailand: A Multicenter Surveillance Study

PubMed Central

Kanoksil, Manas; Jatapai, Anchalee; Peacock, Sharon J.; Limmathurotsakul, Direk

2013-01-01

Background National statistics in developing countries are likely to underestimate deaths due to bacterial infections. Here, we calculated mortality associated with community-acquired bacteremia (CAB) in a developing country using routinely available databases. Methods/Principal Findings Information was obtained from the microbiology and hospital database of 10 provincial hospitals in northeast Thailand, and compared with the national death registry from the Ministry of Interior, Thailand for the period between 2004 and 2010. CAB was defined in patients who had pathogenic organisms isolated from blood taken within 2 days of hospital admission without a prior inpatient episode in the preceding 30 days. A total of 15,251 CAB patients identified, of which 5,722 (37.5%) died within 30 days of admission. The incidence rate of CAB between 2004 and 2010 increased from 16.7 to 38.1 per 100,000 people per year, and the mortality rate associated with CAB increased from 6.9 to 13.7 per 100,000 people per year. In 2010, the mortality rate associated with CAB was lower than that from respiratory tract infection, but higher than HIV disease or tuberculosis. The most common causes of CAB were Escherichia coli (23.1%), Burkholderia pseudomallei (19.3%), and Staphylococcus aureus (8.2%). There was an increase in the proportion of Extended-Spectrum Beta-Lactamases (ESBL) producing E. coli and Klebsiella pneumoniae over time. Conclusions This study has demonstrated that national statistics on causes of death in developing countries could be improved by integrating information from readily available databases. CAB is neglected as an important cause of death, and specific prevention and intervention is urgently required to reduce its incidence and mortality. PMID:23349954

Using Community Advisory Boards to Reduce Environmental Barriers to Health in American Indian Communities, Wisconsin, 2007–2012

PubMed Central

Scott, Jamie R.; Prince, Ron; Williamson, Amy

2014-01-01

Background American Indian communities have a high prevalence of chronic diseases including diabetes, obesity, cardiovascular disease, and cancer. Innovative community-based approaches are needed to identify, prioritize, and create sustainable interventions to reduce environmental barriers to healthy lifestyles and ultimately improve health. Community Context Healthy Children, Strong Families was a family-based and community-based intervention to increase healthy lifestyles on Wisconsin American Indian reservations. This intervention arose from a long-standing partnership between University of Wisconsin researchers and 3 of these American Indian communities. Methods In each community, community advisory boards (CABs) were established by the residents and university partners. CAB meetings were open and held at various times and locations to increase member participation. CABs featured continual, snowball recruitment; internal and external expert consultation; and coordination with standing tribal committees. Meetings initially focused on understanding community supports for and barriers to healthy lifestyles but quickly turned toward community action for change. Outcome CAB interventions decreased environmental barriers to health at each site and improved options for healthy lifestyle choices. Over 5 years, 71 CAB meetings occurred with a total of 1,070 participants. Successful CAB interventions included planting community gardens and an apple orchard, conducting gardening and canning workshops, instituting food-related policies and dog control regulations, building an environmentally friendly playground, and providing access to recreational facilities. The CABs are now self-sustaining. Interpretation CABs can be highly effective action teams capable of improving community environments. Our experience shows that academic researchers can partner with community residents to generate programs and policies that will expand access to local food, increase people’s choices for engaging in physical activity, and encourage local policy changes that improve overall community health. PMID:25232747

Community engagement on the Thai–Burmese border: rationale, experience and lessons learnt

PubMed Central

Cheah, Phaik Yeong; Lwin, Khin Maung; Phaiphun, Lucy; Maelankiri, Ladda; Parker, Michael; Day, Nicholas P.; White, Nicholas J.; Nosten, François

2012-01-01

Community engagement is increasingly promoted in developing countries, especially in international health research, but there is little published experience. The Shoklo Malaria Research Unit (SMRU) conducts research with refugees, migrant workers, displaced people, and day migrants on the Thai-Burmese border, and has recently facilitated the set up of the Tak Province Border Community Ethics Advisory Board (T-CAB). Valuable lessons have been learnt from consultation with the T-CAB especially in the area of participant recruitment and the informed consent process. A lot of new research questions have emerged from consultation with the T-CAB. This paper describes our experience, lessons learnt and the unique challenges faced working with the T-CAB from its initial conception to date. We conclude that consultation with the T-CAB has made improvements in our research in particular operational and ethical aspects of our studies. PMID:22984375

49 CFR Figure 1 to Subpart E of... - Power Car Cab Forward End Structure Conceptual Implementation

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Power Car Cab Forward End Structure Conceptual Implementation 1 Figure 1 to Subpart E of Part 238 Transportation Other Regulations Relating to Transportation... Subpart E of Part 238—Power Car Cab Forward End Structure Conceptual Implementation ER12MY99.000 ...

49 CFR Figure 1 to Subpart E of... - Power Car Cab Forward End Structure Conceptual Implementation

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Power Car Cab Forward End Structure Conceptual Implementation 1 Figure 1 to Subpart E of Part 238 Transportation Other Regulations Relating to Transportation... Subpart E of Part 238—Power Car Cab Forward End Structure Conceptual Implementation ER12MY99.000 ...

Alternative Fuels Data Center: Happy Cab Fuels Taxi Fleet With CNG

Science.gov Websites

Happy Cab Fuels Taxi Fleet With CNG Find out how a cab company in Omaha, Nebraska, saves money fueling Go Electric in Florida Feb. 15, 2014 Renzenberger Inc Saves Money With Propane Vans Feb. 1, 2014 Gas School Buses Help Kansas City Save Money Nov. 12, 2011 Metropolitan Utilities District Fuels

Alternative Fuels Data Center: Yellow Cab Converts Taxis to Propane in

Science.gov Websites

electric car. College Students Engineer Efficient Vehicles in EcoCAR 2 Competition Aug. 2, 2014 Photo of a Columbus, OhioA> Yellow Cab Converts Taxis to Propane in Columbus, Ohio to someone by E-mail how Yellow Cab is overhauling their fleet in Columbus, Ohio, with propane power. For information about

49 CFR Figure 1 to Subpart E of... - Power Car Cab Forward End Structure Conceptual Implementation

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Power Car Cab Forward End Structure Conceptual Implementation 1 Figure 1 to Subpart E of Part 238 Transportation Other Regulations Relating to Transportation... Subpart E of Part 238—Power Car Cab Forward End Structure Conceptual Implementation ER12MY99.000 ...

48 CFR 49.303-5 - Final settlement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Final settlement. 49.303-5 Section 49.303-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

Final Report on the Audit of Architect-Engineer Contracting at the Officer in Charge of Construction, Naval Facilities Engineering Command Contracts, Mediterranean, Madrid, Spain

DTIC Science & Technology

1990-11-30

This is our final report on the audit of Architect-Engineer Contracting for the Officer in Charge of Construction, Naval Facilities Engineering...Command Contracts, Mediterranean, for your information and use. This is the fourth in a series of reports issued as part of the audit of architect-engineer...A-E) contracting. The Contract Management Directorate made the audit from August 1989 through July 1990. When we expanded the audit scope to include

Measuring and modeling air exchange rates inside taxi cabs in Los Angeles, California

NASA Astrophysics Data System (ADS)

Shu, Shi; Yu, Nu; Wang, Yueyan; Zhu, Yifang

2015-12-01

Air exchange rates (AERs) have a direct impact on traffic-related air pollutant (TRAP) levels inside vehicles. Taxi drivers are occupationally exposed to TRAP on a daily basis, yet there is limited measurement of AERs in taxi cabs. To fill this gap, AERs were quantified in 22 representative Los Angeles taxi cabs including 10 Prius, 5 Crown Victoria, 3 Camry, 3 Caravan, and 1 Uplander under realistic driving (RD) conditions. To further study the impacts of window position and ventilation settings on taxi AERs, additional tests were conducted on 14 taxis with windows closed (WC) and on the other 8 taxis with not only windows closed but also medium fan speed (WC-MFS) under outdoor air mode. Under RD conditions, the AERs in all 22 cabs had a mean of 63 h-1 with a median of 38 h-1. Similar AERs were observed under WC condition when compared to those measured under RD condition. Under WC-MFS condition, AERs were significantly increased in all taxi cabs, when compared with those measured under RD condition. A General Estimating Equation (GEE) model was developed and the modeling results showed that vehicle model was a significant factor in determining the AERs in taxi cabs under RD condition. Driving speed and car age were positively associated with AERs but not statistically significant. Overall, AERs measured in taxi cabs were much higher than typical AERs people usually encounter in indoor environments such as homes, offices, and even regular passenger vehicles.

48 CFR 1542.705 - Final indirect cost rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 1542.705 Section 1542.705 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 1542.705 Final indirect cost rates. (a) The... contracts when the Environmental Protection Agency (EPA) is the cognizant federal agency and a FACO will be...

Conceptual design study for an advanced cab and visual system, volume 2

NASA Technical Reports Server (NTRS)

Rue, R. J.; Cyrus, M. L.; Garnett, T. A.; Nachbor, J. W.; Seery, J. A.; Starr, R. L.

1980-01-01

The performance, design, construction and testing requirements are defined for developing an advanced cab and visual system. The rotorcraft system integration simulator is composed of the advanced cab and visual system and the rotorcraft system motion generator, and is part of an existing simulation facility. User's applications for the simulator include rotorcraft design development, product improvement, threat assessment, and accident investigation.

Towards a covariance matrix of CAB model parameters for H(H2O)

NASA Astrophysics Data System (ADS)

Scotta, Juan Pablo; Noguere, Gilles; Damian, José Ignacio Marquez

2017-09-01

Preliminary results on the uncertainties of hydrogen into light water thermal scattering law of the CAB model are presented. It was done through a coupling between the nuclear data code CONRAD and the molecular dynamic simulations code GROMACS. The Generalized Least Square method was used to adjust the model parameters on evaluated data and generate covariance matrices between the CAB model parameters.

A minimal peach type II chlorophyll a/b-binding protein promoter retains tissue-specificity and light regulation in tomato

PubMed Central

Bassett, Carole L; Callahan, Ann M; Artlip, Timothy S; Scorza, Ralph; Srinivasan, Chinnathambi

2007-01-01

Background Promoters with tissue-specificity are desirable to drive expression of transgenes in crops to avoid accumulation of foreign proteins in edible tissues/organs. Several photosynthetic promoters have been shown to be strong regulators of expression of transgenes in light-responsive tissues and would be good candidates for leaf and immature fruit tissue-specificity, if expression in the mature fruit were minimized. Results A minimal peach chlorophyll a/b-binding protein gene (Lhcb2*Pp1) promoter (Cab19) was isolated and fused to an uidA (β-glucuronidase [GUS]) gene containing the PIV2 intron. A control vector carrying an enhanced mas35S CaMV promoter fused to uidA was also constructed. Two different orientations of the Cab19::GUS fusion relative to the left T-DNA border of the binary vector were transformed into tomato. Ten independent regenerants of each construct and an untransformed control line were assessed both qualitatively and quantitatively for GUS expression in leaves, fruit and flowers, and quantitatively in roots. Conclusion The minimal CAB19 promoter conferred GUS activity primarily in leaves and green fruit, as well as in response to light. GUS activity in the leaves of both Cab19 constructs averaged about 2/3 that observed with mas35S::GUS controls. Surprisingly, GUS activity in transgenic green fruit was considerably higher than leaves for all promoter constructs; however, in red, ripe fruit activities were much lower for the Cab19 promoter constructs than the mas35S::GUS. Although GUS activity was readily detectable in flowers and roots of mas35S::GUStransgenic plants, little activity was observed in plants carrying the Cab19 promoter constructs. In addition, the light-inducibility of the Cab19::GUS constructs indicated that all the requisite cis-elements for light responsiveness were contained on the Cab19 fragment. The minimal Cab19 promoter retains both tissue-specificity and light regulation and can be used to drive expression of foreign genes with minimal activity in mature, edible fruit. PMID:17697347

76 FR 53719 - Nondisplacement of Qualified Workers Under Service Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-29

...In this final rule, the Department of Labor (Department or DOL) issues final regulations to implement Executive Order 13495, Nondisplacement of Qualified Workers Under Service Contracts. The Executive Order establishes a general policy of the Federal Government concerning service contracts and solicitations for service contracts for performance of the same or similar services at the same location. This policy mandates the inclusion of a contract clause requiring the successor contractor and its subcontractors to offer those employees employed under the predecessor contract, whose employment will be otherwise terminated as a result of the award of the successor contract, a right of first refusal of employment under the successor contract in positions for which they are qualified.

Fairing Well: Aerodynamic Truck Research at NASA Dryden Flight Research Center. From Shoebox to Bat Truck and Beyond

NASA Technical Reports Server (NTRS)

Gelzer, Christian

2011-01-01

In 1973 engineers at Dryden began investigating ways to reduce aerodynamic drag on land vehicles. They began with a delivery van whose shape they changed dramatically, finally reducing its aerodynamic drag by more than 5 percent. They then turned their attention to tracator-trailers, modifying a cab-over and reducing its aerodynamic drag by nearly 25 percent. Further research identified additional areas worth attention, but in the intervening decades few of those changes have appeared.

The Four-Tier Continuum of Academic and Behavioral Support (4T-CABS) Model: An Integrated Model for Medical Student Success.

PubMed

Stegers-Jager, Karen M; Cohen-Schotanus, Janke; Themmen, Axel P N

2017-11-01

Not all students cope successfully with the demands of medical school, and students' struggles may result in study delay or dropout. To prevent these outcomes, medical schools need to identify students who are experiencing academic difficul ties and provide them with timely interventions through access to support programs. Although the importance of early identification and intervention is well recognized, less is known about successful strategies for identifying and supporting struggling students.Building on the literature and their own empirical findings, the authors propose an integrated, school-wide model for medical student success comprising a continuum of academic and behavioral support. This Four-Tier Continuum of Academic and Behavioral Support (4T-CABS) model focuses on improving both academic and behavioral outcomes by offering support for students at four levels, which range from adequate instruction for all, to targeted small-group interventions, to individualized support, and also include exit support for students who might be better off in another degree program. Additionally, medical schools should provide both academic and behavioral support; set high, yet realistic expectations and clearly communicate these to students; and intervene early, which requires timely identification of at-risk students who would benefit from the different types and tiers of support. Finally, interventions should be evidence based and fit the needs of the identified groups of students. The authors argue that adopting the core principles of the 4T-CABS model will enable medical schools to maximize academic engagement and performance for all students.

Reduction in cab and psb A RNA transcripts in response to supplementary ultraviolet-B radiation.

PubMed

Jordan, B R; Chow, W S; Strid, A; Anderson, J M

1991-06-17

The cab and psb A RNA transcript levels have been determined in Pisum sativum leaves exposed to supplementary ultraviolet-B radiation. The nuclear-encoded cab transcripts are reduced to low levels after only 4 h of UV-B treatment and are undetectable after 3 days exposure. In contrast, the chloroplast-encoded psb A transcript levels, although reduced, are present for at least 3 days. After short periods of UV-B exposure (4 h or 8 h), followed by recovery under control conditions, cab RNA transcript levels had not recovered after 1 day, but were re-established to ca. 60% of control levels after 2 more days. Increased irradiance during exposure to UV-B reduced the effect upon cab transcripts, although the decrease was still substantial. These results indicate rapid changes in the cellular regulation of gene expression in response to supplementary UV-B and suggest increased UV-B radiation may have profound consequences for future productivity of sensitive crop species.

ALP conversion and the soft X-ray excess in the outskirts of the Coma cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraljic, David; Rummel, Markus; Conlon, Joseph P., E-mail: David.Kraljic@physics.ox.ac.uk, E-mail: Markus.Rummel@physics.ox.ac.uk, E-mail: j.conlon1@physics.ox.ac.uk

2015-01-01

It was recently found that the soft X-ray excess in the center of the Coma cluster can be fitted by conversion of axion-like-particles (ALPs) of a cosmic axion background (CAB) to photons. We extend this analysis to the outskirts of Coma, including regions up to 5 Mpc from the center of the cluster. We extract the excess soft X-ray flux from ROSAT All-Sky Survey data and compare it to the expected flux from ALP to photon conversion of a CAB. The soft X-ray excess both in the center and the outskirts of Coma can be simultaneously fitted by ALP tomore » photon conversion of a CAB. Given the uncertainties of the cluster magnetic field in the outskirts we constrain the parameter space of the CAB. In particular, an upper limit on the CAB mean energy and a range of allowed ALP-photon couplings are derived.« less

CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site

PubMed Central

Kurcinski, Mateusz; Jamroz, Michal; Blaszczyk, Maciej; Kolinski, Andrzej; Kmiecik, Sebastian

2015-01-01

Protein–peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein–peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins. While other docking algorithms require pre-defined localization of the binding site, CABS-dock does not require such knowledge. Given a protein receptor structure and a peptide sequence (and starting from random conformations and positions of the peptide), CABS-dock performs simulation search for the binding site allowing for full flexibility of the peptide and small fluctuations of the receptor backbone. This protocol was extensively tested over the largest dataset of non-redundant protein–peptide interactions available to date (including bound and unbound docking cases). For over 80% of bound and unbound dataset cases, we obtained models with high or medium accuracy (sufficient for practical applications). Additionally, as optional features, CABS-dock can exclude user-selected binding modes from docking search or to increase the level of flexibility for chosen receptor fragments. CABS-dock is freely available as a web server at http://biocomp.chem.uw.edu.pl/CABSdock. PMID:25943545

Caffeinated and Non-caffeinated Alcohol Use and Indirect Aggression: The Impact of Self-regulation

PubMed Central

Sheehan, Brynn E.; Linden-Carmichael, Ashley N.; Lau-Barraco, Cathy

2016-01-01

Research shows that heavier alcohol use is associated with physical aggression. Scant research has examined the way in which alcohol relates to other forms of aggression, such as indirect aggression (e.g., malicious humor, social exclusion). Given the possible negative consequences of indirect aggression and the limited evidence suggesting alcohol use can elicit indirectly aggressive responses, research is needed to further investigate the association between drinking behavior and indirect aggression. Additionally, specific alcoholic beverages, such as caffeinated alcoholic beverages (CABs; e.g., Red Bull and vodka), may potentiate aggression above the influence of typical use, thus warrant examination with regard to indirect aggression. One factor that may impact the strength of the alcohol-indirect aggression and CAB-indirect aggression relationships is one's level of self-regulation. Consequently, our study examined the relationships between (1) alcohol use and indirect aggression, (2) CAB use and indirect aggression, and (3) self-regulation as a moderator. Participants were 733 (67.6% female) undergraduate students who reported their CAB and alcohol use, self-regulation, and aggressive behaviors. Results revealed that heavier alcohol use was associated with more frequent indirect aggression after controlling for dispositional aggression. Heavier CAB use was related to more frequent indirect aggression after accounting for typical use and dispositional aggression. Self-regulation moderated these associations such that for those with lower self-regulation, greater alcohol and CAB consumption was associated with greater indirect aggression. Our findings suggest that heavier alcohol and CAB consumption may be risk factors for engaging in indirect aggression and this risk is impacted by one's regulatory control. PMID:26905765

Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol‐containing oral contraceptive in healthy adult women

PubMed Central

Trezza, Christine; Ford, Susan L.; Gould, Elizabeth; Lou, Yu; Huang, Chuyun; Ritter, James M.; Buchanan, Ann M.; Spreen, William

2017-01-01

Aims This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of human immunodeficiency virus‐1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl oestradiol (EO)–containing oral contraceptive (OC) in healthy women. Methods In this open‐label, fixed‐sequence crossover study, healthy female subjects received LNG 0.15 mg/EO 0.03 mg tablet once daily Days 1–10 alone and with oral CAB 30 mg once daily Days 11–21. At the end of each treatment period, subjects underwent predose sampling for concentrations of follicle‐stimulating hormone, luteinizing hormone, and progesterone and serial PK sampling for plasma LNG, EO, and CAB concentrations. Results Twenty women were enrolled, and 19 completed the study. One subject was withdrawn due to an adverse event unrelated to study medications. Geometric least squares mean ratios (90% confidence interval) of LNG + CAB vs. LNG alone for LNG area under the plasma concentration–time curve over the dosing interval of duration τ and maximum observed plasma concentration were 1.12 (1.07–1.18) and 1.05 (0.96–1.15), respectively. Geometric least squares mean ratio (90% confidence interval) of EO + CAB vs. EO alone for EO area under the plasma concentration–time curve over the dosing interval of duration τ and maximum observed plasma concentration were 1.02 (0.97–1.08) and 0.92 (0.83–1.03), respectively. Steady‐state CAB PK parameters were comparable to historical values. There was no apparent difference in mean luteinizing hormone, follicle‐stimulating hormone, and progesterone concentrations between periods. No clinically significant trends in laboratory values, vital signs, or electrocardiography values were observed. Conclusions Repeat doses of oral CAB had no significant effect on LNG/EO PK or pharmacodynamics, which supports CAB coadministration with LNG/EO OCs in clinical practice. PMID:28087972

Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1

PubMed Central

Vig, P.J.S.; Wei, J.; Shao, Q.; Hebert, M.D.; Subramony, S.H.; Sutton, L.T.

2007-01-01

Spinocerebellar ataxia-1 (SCA1) is caused by the expansion of a polyglutamine repeats within the disease protein, ataxin-1. The mutant ataxin-1 precipitates as large intranuclear aggregates in the affected neurons. These aggregates may protect neurons from mutant protein and/or trigger neuronal degeneration by encouraging recruitment of other essential proteins. Our previous studies have shown that calcium binding protein calbindin-D28k (CaB) associated with SCA1 pathogenesis is recruited to ataxin-1 aggregates in Purkinje cells of SCA1 mice. Since our recent findings suggest that tissue transglutaminase 2 (TG2) may be involved in cross-linking and aggregation of ataxin-1, the present study was initiated to determine if TG2 has any role in CaB-ataxin-1 interaction. The guinea pig TG2 covalently cross-linked purified rat brain CaB. Time dependent progressive increase in aggregation produced large multimers, which stayed on top of the gel. CaB interaction with ataxin-1 was studied using HeLa cell lysates expressing GFP and GFP tagged ataxin-1 with normal and expanded polyglutamine repeats (Q2, Q30 and Q82). The reaction products were analyzed by Western blots using anti- polyglutamine, CaB or GFP antibodies. CaB interacted with ataxin-1 independent of TG2 as the protein-protein cross-linker DSS stabilized CaB-ataxin-1 complex. TG2 cross-linked CaB preferentially with Q82 ataxin-1. The cross-linking was inhibited with EGTA or TG2 inhibitor cystamine. The present data indicate that CaB may be a TG2 substrate. In addition, aggregates of mutant ataxin-1 may recruit CaB via TG2 mediated covalent cross-linking, further supporting the argument that ataxin-1 aggregates may be toxic to neurons. PMID:17442486

CAB-Align: A Flexible Protein Structure Alignment Method Based on the Residue-Residue Contact Area.

PubMed

Terashi, Genki; Takeda-Shitaka, Mayuko

2015-01-01

Proteins are flexible, and this flexibility has an essential functional role. Flexibility can be observed in loop regions, rearrangements between secondary structure elements, and conformational changes between entire domains. However, most protein structure alignment methods treat protein structures as rigid bodies. Thus, these methods fail to identify the equivalences of residue pairs in regions with flexibility. In this study, we considered that the evolutionary relationship between proteins corresponds directly to the residue-residue physical contacts rather than the three-dimensional (3D) coordinates of proteins. Thus, we developed a new protein structure alignment method, contact area-based alignment (CAB-align), which uses the residue-residue contact area to identify regions of similarity. The main purpose of CAB-align is to identify homologous relationships at the residue level between related protein structures. The CAB-align procedure comprises two main steps: First, a rigid-body alignment method based on local and global 3D structure superposition is employed to generate a sufficient number of initial alignments. Then, iterative dynamic programming is executed to find the optimal alignment. We evaluated the performance and advantages of CAB-align based on four main points: (1) agreement with the gold standard alignment, (2) alignment quality based on an evolutionary relationship without 3D coordinate superposition, (3) consistency of the multiple alignments, and (4) classification agreement with the gold standard classification. Comparisons of CAB-align with other state-of-the-art protein structure alignment methods (TM-align, FATCAT, and DaliLite) using our benchmark dataset showed that CAB-align performed robustly in obtaining high-quality alignments and generating consistent multiple alignments with high coverage and accuracy rates, and it performed extremely well when discriminating between homologous and nonhomologous pairs of proteins in both single and multi-domain comparisons. The CAB-align software is freely available to academic users as stand-alone software at http://www.pharm.kitasato-u.ac.jp/bmd/bmd/Publications.html.

CABS-flex 2.0: a web server for fast simulations of flexibility of protein structures.

PubMed

Kuriata, Aleksander; Gierut, Aleksandra Maria; Oleniecki, Tymoteusz; Ciemny, Maciej Pawel; Kolinski, Andrzej; Kurcinski, Mateusz; Kmiecik, Sebastian

2018-05-14

Classical simulations of protein flexibility remain computationally expensive, especially for large proteins. A few years ago, we developed a fast method for predicting protein structure fluctuations that uses a single protein model as the input. The method has been made available as the CABS-flex web server and applied in numerous studies of protein structure-function relationships. Here, we present a major update of the CABS-flex web server to version 2.0. The new features include: extension of the method to significantly larger and multimeric proteins, customizable distance restraints and simulation parameters, contact maps and a new, enhanced web server interface. CABS-flex 2.0 is freely available at http://biocomp.chem.uw.edu.pl/CABSflex2.

CABS-fold: Server for the de novo and consensus-based prediction of protein structure.

PubMed

Blaszczyk, Maciej; Jamroz, Michal; Kmiecik, Sebastian; Kolinski, Andrzej

2013-07-01

The CABS-fold web server provides tools for protein structure prediction from sequence only (de novo modeling) and also using alternative templates (consensus modeling). The web server is based on the CABS modeling procedures ranked in previous Critical Assessment of techniques for protein Structure Prediction competitions as one of the leading approaches for de novo and template-based modeling. Except for template data, fragmentary distance restraints can also be incorporated into the modeling process. The web server output is a coarse-grained trajectory of generated conformations, its Jmol representation and predicted models in all-atom resolution (together with accompanying analysis). CABS-fold can be freely accessed at http://biocomp.chem.uw.edu.pl/CABSfold.

CABS-fold: server for the de novo and consensus-based prediction of protein structure

PubMed Central

Blaszczyk, Maciej; Jamroz, Michal; Kmiecik, Sebastian; Kolinski, Andrzej

2013-01-01

The CABS-fold web server provides tools for protein structure prediction from sequence only (de novo modeling) and also using alternative templates (consensus modeling). The web server is based on the CABS modeling procedures ranked in previous Critical Assessment of techniques for protein Structure Prediction competitions as one of the leading approaches for de novo and template-based modeling. Except for template data, fragmentary distance restraints can also be incorporated into the modeling process. The web server output is a coarse-grained trajectory of generated conformations, its Jmol representation and predicted models in all-atom resolution (together with accompanying analysis). CABS-fold can be freely accessed at http://biocomp.chem.uw.edu.pl/CABSfold. PMID:23748950

48 CFR 49.112-2 - Final payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Final payment. 49.112-2 Section 49.112-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.112-2 Final payment. (a) Negotiated settlement. After execution...

48 CFR 942.705 - Final indirect cost rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Final indirect cost rates. 942.705 Section 942.705 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 942.705 Final indirect cost rates. ...

48 CFR 3442.705 - Final indirect cost rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Final indirect cost rates. 3442.705 Section 3442.705 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 3442.705 Final indirect cost rates...

Protection of the vehicle cab environment against bacteria, fungi and endotoxins in composting facilities.

PubMed

Schlosser, O; Huyard, A; Rybacki, D; Do Quang, Z

2012-06-01

Microbial quality of air inside vehicle cabs is a major occupational health risk management issue in composting facilities. Large differences and discrepancies in protection factors between vehicles and between biological agents have been reported. This study aimed at estimating the mean protection efficiency of the vehicle cab environment against bioaerosols with higher precision. In-cab measurement results were also analysed to ascertain whether or not these protection systems reduce workers' exposure to tolerable levels. Five front-end loaders, one mobile mixer and two agricultural tractors pulling windrow turners were investigated. Four vehicles were fitted with a pressurisation and high efficiency particulate air (HEPA) filtration system. The four others were only equipped with pleated paper filter without pressurisation. Bacteria, fungi and endotoxins were measured in 72 pairs of air samples, simultaneously collected inside the cab and on the outside of the cab with a CIP 10-M sampler. A front-end loader, purchased a few weeks previously, fitted with a pressurisation and high efficiency particulate air (HEPA) filtration system, and with a clean cab, exhibited a mean protection efficiency of between 99.47% CI 95% [98.58-99.97%] and 99.91% [99.78-99.98%] depending on the biological agent. It is likely that the lower protection efficiency demonstrated in other vehicles was caused by penetration through the only moderately efficient filters, by the absence of pressurisation, by leakage in the filter-sealing system, and by re-suspension of particles which accumulated in dirty cabs. Mean protection efficiency in regards to bacteria and endotoxins ranged between 92.64% [81.87-97.89%] and 98.61% [97.41-99.38%], and between 92.68% [88.11-96.08%] and 98.43% [97.44-99.22%], respectively. The mean protection efficiency was the lowest when confronted with fungal spores, from 59.76% [4.19-90.75%] to 94.71% [91.07-97.37%]. The probability that in-cab exposure to fungi exceeded the benchmark value for short-term respiratory effects suggests that front-end loaders and mobile mixers in composting facilities should be fitted with a pressurisation and HEPA filtration system, regardless of whether or not the facility is indoors or outdoors. Regarding the tractors, exposure inside the cabs was not significantly reduced. However, in this study, there was a less than 0.01% risk of exceeding the bench mark value associated with fungi related short-term respiratory effects during an 1-h per day windrow turning operation. Pressurisation and a HEPA filtration system can provide safe working conditions inside loaders and mobile mixer with regard to airborne bacteria, fungi and endotoxins in composting facilities. However, regular thorough cleaning of the vehicle cab, as well as overalls and shoes cleaning, and mitigation of leakage in the filter-sealing system are necessary to achieve high levels of protection efficiency. Copyright © 2012 Elsevier Ltd. All rights reserved.

48 CFR 546.312 - Construction contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that include...

48 CFR 546.312 - Construction contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that include...

48 CFR 546.312 - Construction contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that include...

48 CFR 546.312 - Construction contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that include...

Effect of cabergoline on metabolism in prolactinomas.

PubMed

Auriemma, Renata S; Granieri, Luciana; Galdiero, Mariano; Simeoli, Chiara; Perone, Ylenia; Vitale, Pasquale; Pivonello, Claudia; Negri, Mariarosaria; Mannarino, Teresa; Giordano, Carla; Gasperi, Maurizio; Colao, Annamaria; Pivonello, Rosario

2013-01-01

Hyperprolactinemia has been implicated in the pathogenesis of obesity and glucose intolerance and is reportedly associated with an impaired metabolic profile. The current study aimed at investigating the effects of 12- and 60-month treatment with cabergoline (CAB) on metabolic syndrome (MetS) in patients with prolactinomas. 61 patients with prolactinomas (13 men, 48 women, 41 with microadenoma, 20 with macroadenoma), aged 34.4 ± 10.3 years, entered the study. In all patients, prolactin (PRL) and metabolic parameters were assessed at diagnosis and after 12 and 60 months of continuous CAB treatment. MetS was diagnosed according to NCEP-ATP III criteria. Compared to baseline, CAB induced a significant decrease in PRL with complete normalization in 93% of patients after the 60-month treatment. At baseline, MetS prevalence was significantly higher in patients with PRL above (34.5%) than in those with PRL lower (12.5%) than the median (129 μg/l, p = 0.03). MetS prevalence significantly decreased after 12 (11.5%, p = 0.039) and 60 (5.0%, p = 0.001) months compared to baseline (28.0%). At both evaluations the lipid profile significantly improved compared to baseline. Fasting insulin and homeostatic model assessment of insulin resistance significantly decreased after 1 year of CAB (p = 0.012 and p = 0.002, respectively) and further improved after 60 months (p = 0.000). The visceral adiposity index significantly decreased after the 60-month treatment (p = 0.000) compared to baseline. At the 5-year evaluation CAB dose was the best predictor of percent decrease in fasting insulin (t = 2.35, p = 0.022). CAB significantly reduces MetS prevalence and improves the adipose tissue dysfunction index. The improvement in PRL, insulin sensitivity and other metabolic parameters might reflect the direct effect of CAB. © 2013 S. Karger AG, Basel.

Evaluation of welfare advice in primary care: effect on practice workload and prescribing for mental health.

PubMed

Krska, Janet; Palmer, Sharon; Dalzell-Brown, Annette; Nicholl, Pat

2013-07-01

To determine Citizen's Advice Bureaux (CAB) and general practice staff perceptions on the impact of a CAB Health Outreach (CABHO) service on staff workload. To quantify the frequency of mental health issues among patients referred to the CABHO service. To measure any impact of the CABHO service on appointments, referrals and prescribing for mental health. GPs and practice managers perceive that welfare rights services, provided by CAB, reduce practice staff workload, but this has not been quantified. Interviews with practice managers and GPs hosting and CAB staff providing an advisory service in nine general practices. Comparison of frequency of GP and nurse appointments, mental health referrals and prescriptions for hypnotics/anxiolytics and antidepressants issued before and after referral to the CABHO service, obtained from medical records of referred patients. Most GPs and CAB staff perceived the service reduced practice staff workload, although practice managers were less certain. CAB staff believed that many patients referred to them had mental health issues. Data were obtained for 148/250 referrals of whom 46% may have had a mental health issue. There were statistically significant reductions in the number of GP appointments and prescriptions for hypnotics/anxiolytics during the six months after referral to CABHO compared with six months before. There were also non-significant reductions in nurse appointments and prescriptions for antidepressants, but no change in appointments or referrals for mental health problems. The quantitative findings therefore confirmed perceptions among both CAB and practice staff of reduced workload and in addition suggest that prescribing may be reduced, although further larger-scale studies are required to confirm this.

48 CFR 842.705 - Final indirect cost rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Final indirect cost rates. 842.705 Section 842.705 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 842.705 Final indirect cost rates...

A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System

NASA Astrophysics Data System (ADS)

Geng, Shengyong; Wang, Yuzhu; Wang, Liping; Kouyama, Tsutomu; Gotoh, Toshiaki; Wada, Satoshi; Wang, Jin-Ye

2017-01-01

The structure of a self-assembly formed from a cationic azobenzene derivative, 4-cholesterocarbonyl-4‧-(N,N,N-triethylamine butyloxyl bromide) azobenzene (CAB) and surfactant sodium dodecyl sulfate (SDS) in aqueous solution was studied by cryo-TEM and synchrotron radiation small-angle X-ray scattering (SAXS). Both unilamellar and multilamellar vesicles could be observed. CAB in vesicles were capable to undergo reversible trans-to-cis isomerization upon UV or visible light irradiation. The structural change upon UV light irradiation could be catched by SAXS, which demonstrated that the interlamellar spacing of the cis-multilamellar vesicles increased by 0.2-0.3 nm. Based on this microstructural change, the release of rhodamine B (RhB) and doxorubicin (DOX) could be triggered by UV irradiation. When incubated NIH 3T3 cells and Bel 7402 cells with DOX-loaded CAB/SDS vesicles, UV irradiation induced DOX release decreased the viability of both cell lines significantly compared with the non-irradiated cells. The in vitro experiment indicated that CAB/SDS vesicles had high efficiency to deliver loaded molecules into cells. The in vivo experiment showed that CAB/SDS vesicles not only have high drug delivery efficiency into rat retinas, but also could maintain high drug concentration for a longer time. CAB/SDS catanionic vesicles may find potential applications as a smart drug delivery system for controlled release by light.

CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site.

PubMed

Kurcinski, Mateusz; Jamroz, Michal; Blaszczyk, Maciej; Kolinski, Andrzej; Kmiecik, Sebastian

2015-07-01

Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins. While other docking algorithms require pre-defined localization of the binding site, CABS-dock does not require such knowledge. Given a protein receptor structure and a peptide sequence (and starting from random conformations and positions of the peptide), CABS-dock performs simulation search for the binding site allowing for full flexibility of the peptide and small fluctuations of the receptor backbone. This protocol was extensively tested over the largest dataset of non-redundant protein-peptide interactions available to date (including bound and unbound docking cases). For over 80% of bound and unbound dataset cases, we obtained models with high or medium accuracy (sufficient for practical applications). Additionally, as optional features, CABS-dock can exclude user-selected binding modes from docking search or to increase the level of flexibility for chosen receptor fragments. CABS-dock is freely available as a web server at http://biocomp.chem.uw.edu.pl/CABSdock. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Final Product Strategies in Purchasing and Their Impact on the Information Needs of the Organisation.

ERIC Educational Resources Information Center

Inbar, David

Purchasing contributes significantly to an organization and to its business strategy only if its activities and contracts with suppliers are guided by support criteria for the final products that the organization sells. Outlined in this paper are four innovative purchasing strategies: capitation contracts; product life cycle cost contracts;…

Intelligent Shuttle Management and Routing Algorithm

NASA Astrophysics Data System (ADS)

Thomas, Toshen M.; Subashanthini, S.

2017-11-01

Nowadays, most of the big Universities and campuses have Shuttle cabs running in them to cater the transportational needs of the students and faculties. While some shuttle services ask for a meagre sum to be paid for the usage, no digital payment system is onboard these vehicles to go truly cashless. Even more troublesome is the fact that sometimes during the day, some of these cabs run with bare number of passengers, which can result in unwanted budget loss to the shuttle operator. The main purpose of this paper is to create a system with two types of applications: A web portal and an Android app, to digitize the Shuttle cab industry. This system can be used for digital cashless payment feature, tracking passengers, tracking cabs and more importantly, manage the number of shuttle cabs in every route to maximize profit. This project is built upon an ASP.NET website connected to a cloud service along with an Android app that tracks and reads the passengers ID using an attached barcode reader along with the current GPS coordinates, and sends these data to the cloud for processing using the phone’s internet connectivity.

Monogamy equality in 2⊗2⊗d quantum systems

NASA Astrophysics Data System (ADS)

Chi, Dong Pyo; Choi, Jeong Woon; Jeong, Kabgyun; San Kim, Jeong; Kim, Taewan; Lee, Soojoon

2008-11-01

There is an interesting property about multipartite entanglement, called the monogamy of entanglement. The property can be shown by the monogamy inequality, called the Coffman-Kundu-Wootters inequality [Phys. Rev. A 61, 052306 (2000); Coffman-Kundu-WoottersPhys. Rev. Lett. 96, 220503 (2006)], and more explicitly by the monogamy equality in terms of the concurrence and the concurrence of assistance, CA(BC)2=CAB2+(CACa)2, in the three-qubit system. In this paper, we consider the monogamy equality in 2⊗2⊗d quantum systems. We show that CA(BC)=CAB if and only if CACa=0 and also show that if CA(BC)=CACa, then CAB=0, while there exists a state in a 2⊗2⊗d system such that CAB=0 but CA(BC)>CACa.

[Claim and reality of selective contact options : experiences in finalizing selective contracts in urological care].

PubMed

Ex, P; Schroeder, A

2014-08-01

Selective contracts are an important component in addition to the total healthcare concept in order to introduce process-related innovations into the healthcare system. Since 2011 the Berufsverband der Deutschen Urologen (BDU, Professional Association of German Urologists) has held negotiations with individual health insurance companies and care providers in order to view selective contracts as collective contracts, not only as pilot projects but also as additional forms of care.This article illustrates the experiences of the BDU in the initiation and finalizing of selective contracts as well as existing weak points in the framework conditions.

Cost and Schedule Analytical Techniques Development

NASA Technical Reports Server (NTRS)

1996-01-01

This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) for the base contract year from December 1, 1994 through November 30, 1995. The Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides technical services and products to the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PP03) and the Program Plans and Requirements Office (PP02). Detailed Monthly Progress Reports were submitted to MSFC in accordance with the contract's Statement of Work Section IV "Reporting and Documentation". These reports spelled out each month's specific work accomplishments, deliverables submitted, major meetings held, and other pertinent information. This Final Report will summarize these activities at a higher level.

Center for Advanced Biofuel Systems (CABS) Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutchan, Toni M.

2015-12-02

One of the great challenges facing current and future generations is how to meet growing energy demands in an environmentally sustainable manner. Renewable energy sources, including wind, geothermal, solar, hydroelectric, and biofuel energy systems, are rapidly being developed as sustainable alternatives to fossil fuels. Biofuels are particularly attractive to the U.S., given its vast agricultural resources. The first generation of biofuel systems was based on fermentation of sugars to produce ethanol, typically from food crops. Subsequent generations of biofuel systems, including those included in the CABS project, will build upon the experiences learned from those early research results and willmore » have improved production efficiencies, reduced environmental impacts and decreased reliance on food crops. Thermodynamic models predict that the next generations of biofuel systems will yield three- to five-fold more recoverable energy products. To address the technological challenges necessary to develop enhanced biofuel systems, greater understanding of the non-equilibrium processes involved in solar energy conversion and the channeling of reduced carbon into biofuel products must be developed. The objective of the proposed Center for Advanced Biofuel Systems (CABS) was to increase the thermodynamic and kinetic efficiency of select plant- and algal-based fuel production systems using rational metabolic engineering approaches grounded in modern systems biology. The overall strategy was to increase the efficiency of solar energy conversion into oils and other specialty biofuel components by channeling metabolic flux toward products using advanced catalysts and sensible design:1) employing novel protein catalysts that increase the thermodynamic and kinetic efficiencies of photosynthesis and oil biosynthesis; 2) engineering metabolic networks to enhance acetyl-CoA production and its channeling towards lipid synthesis; and 3) engineering new metabolic networks for the production of hydrocarbons required to meet commercial fuel standards.« less

Comparison of MERV 16 and HEPA filters for cab filtration of underground mining equipment.

PubMed

Cecala, A B; Organiscak, J A; Noll, J D; Zimmer, J A

2016-08-01

Significant strides have been made in optimizing the design of filtration and pressurization systems used on the enclosed cabs of mobile mining equipment to reduce respirable dust and provide the best air quality to the equipment operators. Considering all of the advances made in this area, one aspect that still needed to be evaluated was a comparison of the efficiencies of the different filters used in these systems. As high-efficiency particulate arrestance (HEPA) filters provide the highest filtering efficiency, the general assumption would be that they would also provide the greatest level of protection to workers. Researchers for the U.S. National Institute for Occupational Safety and Health (NIOSH) speculated, based upon a previous laboratory study, that filters with minimum efficiency reporting value, or MERV rating, of 16 may be a more appropriate choice than HEPA filters in most cases for the mining industry. A study was therefore performed comparing HEPA and MERV 16 filters on two kinds of underground limestone mining equipment, a roof bolter and a face drill, to evaluate this theory. Testing showed that, at the 95-percent confidence level, there was no statistical difference between the efficiencies of the two types of filters on the two kinds of mining equipment. As the MERV 16 filters were less restrictive, provided greater airflow and cab pressurization, cost less and required less-frequent replacement than the HEPA filters, the MERV 16 filters were concluded to be the optimal choice for both the roof bolter and the face drill in this comparative-analysis case study. Another key finding of this study is the substantial improvement in the effectiveness of filtration and pressurization systems when using a final filter design.

Comparison of MERV 16 and HEPA filters for cab filtration of underground mining equipment

PubMed Central

Cecala, A.B.; Organiscak, J.A.; Noll, J.D.; Zimmer, J.A.

2016-01-01

Significant strides have been made in optimizing the design of filtration and pressurization systems used on the enclosed cabs of mobile mining equipment to reduce respirable dust and provide the best air quality to the equipment operators. Considering all of the advances made in this area, one aspect that still needed to be evaluated was a comparison of the efficiencies of the different filters used in these systems. As high-efficiency particulate arrestance (HEPA) filters provide the highest filtering efficiency, the general assumption would be that they would also provide the greatest level of protection to workers. Researchers for the U.S. National Institute for Occupational Safety and Health (NIOSH) speculated, based upon a previous laboratory study, that filters with minimum efficiency reporting value, or MERV rating, of 16 may be a more appropriate choice than HEPA filters in most cases for the mining industry. A study was therefore performed comparing HEPA and MERV 16 filters on two kinds of underground limestone mining equipment, a roof bolter and a face drill, to evaluate this theory. Testing showed that, at the 95-percent confidence level, there was no statistical difference between the efficiencies of the two types of filters on the two kinds of mining equipment. As the MERV 16 filters were less restrictive, provided greater airflow and cab pressurization, cost less and required less-frequent replacement than the HEPA filters, the MERV 16 filters were concluded to be the optimal choice for both the roof bolter and the face drill in this comparative-analysis case study. Another key finding of this study is the substantial improvement in the effectiveness of filtration and pressurization systems when using a final filter design. PMID:27524838

Dual mechanism controls asymmetric spindle position in ascidian germ cell precursors.

PubMed

Prodon, François; Chenevert, Janet; Hébras, Céline; Dumollard, Rémi; Faure, Emmanuel; Gonzalez-Garcia, Jose; Nishida, Hiroki; Sardet, Christian; McDougall, Alex

2010-06-01

Mitotic spindle orientation with respect to cortical polarity cues generates molecularly distinct daughter cells during asymmetric cell division (ACD). However, during ACD it remains unknown how the orientation of the mitotic spindle is regulated by cortical polarity cues until furrowing begins. In ascidians, the cortical centrosome-attracting body (CAB) generates three successive unequal cleavages and the asymmetric segregation of 40 localized postplasmic/PEM RNAs in germ cell precursors from the 8-64 cell stage. By combining fast 4D confocal fluorescence imaging with gene-silencing and classical blastomere isolation experiments, we show that spindle repositioning mechanisms are active from prometaphase until anaphase, when furrowing is initiated in B5.2 cells. We show that the vegetal-most spindle pole/centrosome is attracted towards the CAB during prometaphase, causing the spindle to position asymmetrically near the cortex. Next, during anaphase, the opposite spindle pole/centrosome is attracted towards the border with neighbouring B5.1 blastomeres, causing the spindle to rotate (10 degrees /minute) and migrate (3 microm/minute). Dynamic 4D fluorescence imaging of filamentous actin and plasma membrane shows that precise orientation of the cleavage furrow is determined by this second phase of rotational spindle displacement. Furthermore, in pairs of isolated B5.2 blastomeres, the second phase of rotational spindle displacement was lost. Finally, knockdown of PEM1, a protein localized in the CAB and required for unequal cleavage in B5.2 cells, completely randomizes spindle orientation. Together these data show that two separate mechanisms active during mitosis are responsible for spindle positioning, leading to precise orientation of the cleavage furrow during ACD in the cells that give rise to the germ lineage in ascidians.

Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol-containing oral contraceptive in healthy adult women.

PubMed

Trezza, Christine; Ford, Susan L; Gould, Elizabeth; Lou, Yu; Huang, Chuyun; Ritter, James M; Buchanan, Ann M; Spreen, William; Patel, Parul

2017-07-01

This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of human immunodeficiency virus-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl oestradiol (EO)-containing oral contraceptive (OC) in healthy women. In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EO 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21. At the end of each treatment period, subjects underwent predose sampling for concentrations of follicle-stimulating hormone, luteinizing hormone, and progesterone and serial PK sampling for plasma LNG, EO, and CAB concentrations. Twenty women were enrolled, and 19 completed the study. One subject was withdrawn due to an adverse event unrelated to study medications. Geometric least squares mean ratios (90% confidence interval) of LNG + CAB vs. LNG alone for LNG area under the plasma concentration-time curve over the dosing interval of duration τ and maximum observed plasma concentration were 1.12 (1.07-1.18) and 1.05 (0.96-1.15), respectively. Geometric least squares mean ratio (90% confidence interval) of EO + CAB vs. EO alone for EO area under the plasma concentration-time curve over the dosing interval of duration τ and maximum observed plasma concentration were 1.02 (0.97-1.08) and 0.92 (0.83-1.03), respectively. Steady-state CAB PK parameters were comparable to historical values. There was no apparent difference in mean luteinizing hormone, follicle-stimulating hormone, and progesterone concentrations between periods. No clinically significant trends in laboratory values, vital signs, or electrocardiography values were observed. Repeat doses of oral CAB had no significant effect on LNG/EO PK or pharmacodynamics, which supports CAB coadministration with LNG/EO OCs in clinical practice. © 2017 ViiV Healthcare. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Improved Mapping of Carbon, Water and Energy Land-Surface Fluxes Using Remotely Sensed Indicators of Canopy Light Use Efficiency

NASA Astrophysics Data System (ADS)

Schull, M. A.; Anderson, M. C.; Kustas, W.; Cammalleri, C.; Houborg, R.

2012-12-01

A light-use-efficiency (LUE) based model of canopy resistance has been embedded into a thermal-based Two-Source Energy Balance (TSEB) model to facilitate coupled simulations of transpiration and carbon assimilation. The model assumes that deviations of the observed canopy LUE from a nominal stand-level value (LUEn - typically indexed by vegetation class) are due to varying conditions of light, humidity, CO2 concentration and leaf temperature. The deviations are accommodated by adjusting an effective LUE that responds to the varying conditions. The challenge to monitoring fluxes on a larger scale is to capture the physiological responses due to changing conditions. This challenge can be met using remotely sensed leaf chlorophyll (Cab). Since Cab is a vital pigment for absorbing light for use in photosynthesis, it has been recognized as a key parameter for quantifying photosynthetic functioning that are sensitive to these conditions. Recent studies have shown that it is sensitive to changes in LUE, which defines how efficiently a plant can assimilate carbon dioxide (CO2) given the absorbed Photosynthetically Active Radiation (PAR) and is therefore useful for monitoring carbon fluxes. We investigate the feasibility of leaf chlorophyll to capture these variations in LUEn using remotely sensed data. To retrieve Cab from remotely sensed data we use REGFLEC, a physically based tool that translates at-sensor radiances in the green, red and NIR spectral regions from multiple satellite sensors into realistic maps of LAI and Cab. Initial results show that Cab is exponentially correlated to light use efficiency. Incorporating nominal light use efficiency estimated from Cab is shown to improve fluxes of carbon, water and energy most notably in times of stressed vegetation. The result illustrates that Cab is sensitive to changes in plant physiology and can capture plant stress needed for improved estimation of fluxes. The observed relationship and initial results demonstrate the need for integrating remotely sensed Cab to facilitate improved mapping of coupled carbon, water, and energy fluxes across vegetated landscapes.

Federal employees health benefits program; revision of contract cost principles and procedures, and miscellaneous changes. Final rule.

PubMed

2005-06-01

The U.S. Office of Personnel Management (OPM) is issuing a final regulation amending the Federal Employees Health Benefits (FEHB) Acquisition Regulation (FEHBAR). This regulation provides additional contract cost principles and procedures for FEHB Program experience-rated contracts and is intended to clarify our requirements and enhance our oversight of FEHB carriers.

Equipment boxes (later addition) one level down from antenna cab, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Equipment boxes (later addition) one level down from antenna cab, looking southwest. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

Antenna cab interior showing equipment rack and fiberglass antenna panels, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Antenna cab interior showing equipment rack and fiberglass antenna panels, looking west. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

Antenna cab interior showing equipment rack and fiberglass antenna panels, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Antenna cab interior showing equipment rack and fiberglass antenna panels, looking southeast. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

Chemical weathering in response to tectonic uplift and denudation rate in a semi-arid environment, southeast Spain

NASA Astrophysics Data System (ADS)

Ameijeiras-Mariño, Yolanda; Opfergelt, Sophie; Schoonejans, Jérôme; Vanacker, Veerle; Sonnet, Philippe; Delmelle, Pierre

2014-05-01

Soil thickness reflects the balance between soil production and denudation by chemical weathering and physical erosion. At topographic steady state, the soil weathering intensity is expected to be higher at low denudation rate (transport-limited) than at high denudation rate (weathering-limited). We tested this hypothesis for the first time in a semi-arid environment where chemical weathering processes are generally slow. The study site is the Internal Zone of the Betic Cordillera in Southeast Spain, Almeria province. The lithology is mainly mica-schist and quartzite with local presence of phyllite. Three catchments (EST, FIL, CAB) were selected upstream local faults along a gradient of increasing uplift rates (10-170 mm/kyr) and increasing denudation rates (20-250 mm/kyr), following the sequence EST

12. ELEVATOR DOORS AND CAB. Hot Springs National Park, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. ELEVATOR DOORS AND CAB. - Hot Springs National Park, Bathhouse Row, Fordyce Bathhouse: Mechanical & Piping Systems, State Highway 7, 1 mile north of U.S. Highway 70, Hot Springs, Garland County, AR

Antenna cab interior showing waveguide from external parabolic antenna (later ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Antenna cab interior showing waveguide from external parabolic antenna (later addition), looking north. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

View of 175 ton hoisthouse from northeast. Hoist operator's cab ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of 175 ton hoist-house from northeast. Hoist operator's cab is in foreground center. - Marshall Space Flight Center, Saturn V Dynamic Test Facility, East Test Area, Huntsville, Madison County, AL

Capillary-Driven Microfluidic Chips for Miniaturized Immunoassays: Patterning Capture Antibodies Using Microcontact Printing and Dry-Film Resists.

PubMed

Temiz, Yuksel; Lovchik, Robert D; Delamarche, Emmanuel

2017-01-01

The miniaturization of immunoassays using microfluidic devices is attractive for many applications, but an important challenge remains the patterning of capture antibodies (cAbs) on the surface of microfluidic structures. Here, we describe how to pattern cAbs on planar poly(dimethylsiloxane) (PDMS) stamps and how to microcontact print the cAbs on a dry-film resist (DFR). DFRs are new types of photoresists having excellent chemical resistance and good mechanical, adhesive, and optical properties. Instead of being liquid photoresists, DFRs are thin layers that are easy to handle, cut, photo-pattern, and laminate over surfaces. We show how to perform a simple fluorescence immunoassay using anti-biotin cAbs patterned on a 50-μm-thick DF-1050 DFR, Atto 647N-biotin analytes, and capillary-driven chips fabricated in silicon.

The Child Adolescent Bullying Scale (CABS): Psychometric evaluation of a new measure.

PubMed

Strout, Tania D; Vessey, Judith A; DiFazio, Rachel L; Ludlow, Larry H

2018-06-01

While youth bullying is a significant public health problem, healthcare providers have been limited in their ability to identify bullied youths due to the lack of a reliable, and valid instrument appropriate for use in clinical settings. We conducted a multisite study to evaluate the psychometric properties of a new 22-item instrument for assessing youths' experiences of being bullied, the Child Adolescent Bullying Scale (CABS). The 20 items summed to produce the measure's score were evaluated here. Diagnostic performance was assessed through evaluation of sensitivity, specificity, predictive values, and area under receiver operating characteristic (AUROC) curve. A sample of 352 youths from diverse racial, ethnic, and geographic backgrounds (188 female, 159 male, 5 transgender, sample mean age 13.5 years) were recruited from two clinical sites. Participants completed the CABS and existing youth bullying measures. Analyses grounded in classical test theory, including assessments of reliability and validity, item analyses, and principal components analysis, were conducted. The diagnostic performance and test characteristics of the CABS were also evaluated. The CABS is comprised of one component, accounting for 67% of observed variance. Analyses established evidence of internal consistency reliability (Cronbach's α = 0.97), construct and convergent validity. Sensitivity was 84%, specificity was 65%, and the AUROC curve was 0.74 (95% CI: 0.69-0.80). Findings suggest that the CABS holds promise as a reliable, valid tool for healthcare provider use in screening for bullying exposure in the clinical setting. © 2018 Wiley Periodicals, Inc.

Development, characterization and dissolution behavior of calcium-aluminoborate glass wasteforms to immobilize rare-earth oxides.

PubMed

Kim, Miae; Corkhill, Claire L; Hyatt, Neil C; Heo, Jong

2018-03-28

Calcium-aluminoborate (CAB) glasses were developed to sequester new waste compositions made of several rare-earth oxides generated from the pyrochemical reprocessing of spent nuclear fuel. Several important wasteform properties such as waste loading, processability and chemical durability were evaluated. The maximum waste loading of the CAB compositions was determined to be ~56.8 wt%. Viscosity and the electrical conductivity of the CAB melt at 1300 °C were 7.817 Pa·s and 0.4603 S/cm, respectively, which satisfies the conditions for commercial cold-crucible induction melting (CCIM) process. Addition of rare-earth oxides to CAB glasses resulted in dramatic decreases in the elemental releases of B and Ca in aqueous dissolution experiments. Normalized elemental releases from product consistency standard chemical durability test were <3.62·10 -5  g·m -2 for Nd, 0.009 g·m -2 for Al, 0.067 g·m -2 for B and 0.073 g·m -2 for Ca (at 90, after 7 days, for SA/V = 2000m -1 ); all meet European and US regulation limits. After 20 d of dissolution, a hydrated alteration layer of ~ 200-nm-thick, Ca-depleted and Nd-rich, was formed at the surface of CAB glasses with 20 mol% Nd 2 O 3 whereas boehmite [AlO(OH)] secondary crystalline phases were formed in pure CAB glass that contained no Nd 2 O 3 .

Biomechanical effects of mobile computer location in a vehicle cab.

PubMed

Saginus, Kyle A; Marklin, Richard W; Seeley, Patricia; Simoneau, Guy G; Freier, Stephen

2011-10-01

The objective of this research is to determine the best location to place a conventional mobile computer supported by a commercially available mount in a light truck cab. U.S. and Canadian electric utility companies are in the process of integrating mobile computers into their fleet vehicle cabs. There are no publications on the effect of mobile computer location in a vehicle cab on biomechanical loading, performance, and subjective assessment. The authors tested four locations of mobile computers in a light truck cab in a laboratory study to determine how location affected muscle activity of the lower back and shoulders; joint angles of the shoulders, elbows, and wrist; user performance; and subjective assessment. A total of 22 participants were tested in this study. Placing the mobile computer closer to the steering wheel reduced low back and shoulder muscle activity. Joint angles of the shoulders, elbows, and wrists were also closer to neutral angle. Biomechanical modeling revealed substantially less spinal compression and trunk muscle force. In general, there were no practical differences in performance between the locations. Subjective assessment indicated that users preferred the mobile computer to be as close as possible to the steering wheel. Locating the mobile computer close to the steering wheel reduces risk of injuries, such as low back pain and shoulder tendonitis. Results from the study can guide electric utility companies in the installation of mobile computers into vehicle cabs. Results may also be generalized to other industries that use trucklike vehicles, such as construction.

23 CFR 635.121 - Contract time and contract time extensions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... time extensions. (a) The STD should have adequate written procedures for the determination of contract... of the effective date of this Final Rule. (b) Contract time extensions granted by a STD shall be...

23 CFR 635.121 - Contract time and contract time extensions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... time extensions. (a) The STD should have adequate written procedures for the determination of contract... of the effective date of this Final Rule. (b) Contract time extensions granted by a STD shall be...

23 CFR 635.121 - Contract time and contract time extensions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... time extensions. (a) The STD should have adequate written procedures for the determination of contract... of the effective date of this Final Rule. (b) Contract time extensions granted by a STD shall be...

23 CFR 635.121 - Contract time and contract time extensions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... time extensions. (a) The STD should have adequate written procedures for the determination of contract... of the effective date of this Final Rule. (b) Contract time extensions granted by a STD shall be...

24 CFR 242.52 - Construction contracts.

Code of Federal Regulations, 2013 CFR

2013-04-01

...; a construction management contract with a guaranteed maximum price, the final costs of which are... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A...

Cost and Schedule Analytical Techniques Development: Option 1

NASA Technical Reports Server (NTRS)

1996-01-01

This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) for the base contract year from December 1, 1995 through November 30, 1996. The Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides technical services and products to the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PPO3) and the Program Plans and Requirements Officer (PPO2). Detailed Monthly Progress Reports were submitted to MSFC in accordance with the contract's Statement of Work Section IV "Reporting and Documentation". These reports spelled out each month's specific work accomplishments, deliverables submitted, major meetings held, and other pertinent information. This Final Report will summarize these activities at a higher level.

Locomotive cab occupant protection

DOT National Transportation Integrated Search

2003-11-15

The effectiveness of fitting a locomotive cab with a passive inflatable restraint system utilizing inflatable structures, and interior padding to protect the operator has been evaluated for the in-line collision scenario. It is a challenge to design ...

Evaluation of cab car crashworthiness design modifications

DOT National Transportation Integrated Search

1997-03-01

A study was conducted to evaluate the effectiveness of structural : modifications to rail cab cars for increased crashworthiness protection in train collisions. The crashworthiness benefits were calculated based on a particular design's ability to pr...

Clean Cities case study : Barwood Cab Fleet study summary

DOT National Transportation Integrated Search

1999-05-21

Barwood Cab Fleet Study Summary is the second in a new series called 'Alternative Fuel Information Case Studies', designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders.

The Effects of Curtain Airbag on Occupant Kinematics and Injury Index in Rollover Crash

PubMed Central

Li, Hongyun; Cui, Dong; Lu, Shuang

2018-01-01

Background Occupant injuries in rollover crashes are associated with vehicle structural performance, as well as the restraint system design. For a better understanding of the occupant kinematics and injury index in certain rollover crash, it is essential to carry out dynamic vehicle rollover simulation with dummy included. Objective This study focused on effects of curtain airbag (CAB) parameters on occupant kinematics and injury indexes in a rollover crash. Besides, optimized parameters of the CAB were proposed for the purpose of decreasing the occupant injuries in such rollover scenario. Method and Material The vehicle motion from the physical test was introduced as the input for the numerical simulation, and the 50% Hybrid III dummy model from the MADYMO database was imported into a simulation model. The restraint system, including a validated CAB module, was introduced for occupant kinematics simulation and injury evaluation. TTF setting, maximum inflator pressure, and protection area of the CAB were analysed. Results After introducing the curtain airbag, the maximum head acceleration was reduced from 91.60 g to 49.52 g, and the neck Mx and neck Fz were reduced significantly. Among these CAB parameters, the TTF setting had the largest effect on the head acceleration which could reduce 8.6 g furthermore after optimization. The neck Fz was decreased from 3766.48 N to 2571.77 N after optimization of CAB protection area. Conclusions Avoiding hard contact is critical for the occupant protection in the rollover crashes. The simulation results indicated that occupant kinematics and certain injury indexes were improved with the help of CAB in such rollover scenario. Appropriate TTF setting and inflator selection could benefit occupant kinematics and injury indexes. Besides, it was advised to optimize the curtain airbag thickness around the head contact area to improve head and neck injury indexes. PMID:29765463

Next generation locomotive cab task 5 summary report : control stand design.

DOT National Transportation Integrated Search

2010-07-01

This report discusses the development of a user-centered control stand for the Federal Railroad Administrations Next Generation Locomotive Cab Demonstration Program. A modified Association of American Railroads 105 side-mounted control stand...

Cab technology integration laboratory demonstration with moving map technology

DOT National Transportation Integrated Search

2013-03-31

A human performance study was conducted at the John A. Volpe National Transportation Systems Center (Volpe Center) using a locomotive research simulatorthe Cab Technology Integration Laboratory (CTIL)that was acquired by the Federal Railroad Ad...

78 FR 72572 - Operational Contract Support

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-03

... 0790-AI48 Operational Contract Support AGENCY: Department of Defense (DoD). ACTION: Final rule. SUMMARY: This rule establishes policy, assigns responsibilities, and provides procedures for operational contract support (OCS), including OCS program management, contract support integration, and integration of...

34 CFR 5.72 - Records available.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Department or not. (c) Contracts. (1) Contract instruments. (2) Portions of offers reflecting final prices submitted in negotiated procurements. (d) Reports on grantee, contractor, or provider performance. Final... projects, such as films, computer software, other copyrightable materials and reports of inventions, will...

48 CFR 2027.305-3 - Follow-up by Government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... provide the following written determination before final payment and closeout of the contract: (1) No inventions or discoveries were made, (2) No copyrights were secured, produced, or composed, (3) No notices or... any final payment and closing out the contract. ...

The influence of crystal habit on the prediction of dry powder inhalation formulation performance using the cohesive-adhesive force balance approach.

PubMed

Hooton, Jennifer C; Jones, Matthew D; Harris, Haggis; Shur, Jagdeep; Price, Robert

2008-09-01

The aim of this investigation was to study the influence of crystalline habit of active pharmaceutical ingredients on the cohesive-adhesive force balance within model dry powder inhaler (DPI) formulations and the corresponding affect on DPI formulation performance. The cohesive-adhesive balance (CAB) approach to colloid probe atomic force microscopy (AFM) was employed to determine the cohesive and adhesive interactions of micronized budesonide particles against the {102} and {002} faces of budesonide single crystals and crystalline substrates of different sugars (cyclodextrin, lactose, trehalose, raffinose, and xylitol), respectively. These data were used to measure the relative level of cohesion and adhesion via CAB and the possible influence on in vitro performance of a carrier-based DPI formulation. Varying the crystal habit of the drug had a significant effect on the cohesive measurement of micronized budesonide probes, with the cohesive values on the {102} faces being approximately twice that on the {002} crystal faces. However, although different CAB values were measured with the sugars with respect to the crystal faces chosen for the cohesive-based measurement, the overall influence on the rank order of the CAB values was not directly influenced. For these data sets, the CAB gradient indicated that a decrease in the dominance of the adhesive forces led to a concomitant increase in fine particle delivery, reaching a plateau as the cohesive forces became dominant. The study suggested that crystal habit of the primary drug crystals influences the cohesive interactions and the resulting force balance measurements of colloid probe CAB analysis.

U.S. truck driver anthropometric study and multivariate anthropometric models for cab designs.

PubMed

Guan, Jinhua; Hsiao, Hongwei; Bradtmiller, Bruce; Kau, Tsui-Ying; Reed, Matthew R; Jahns, Steven K; Loczi, Josef; Hardee, H Lenora; Piamonte, Dominic Paul T

2012-10-01

This study presents data from a large-scale anthropometric study of U.S. truck drivers and the multivariate anthropometric models developed for the design of next-generation truck cabs. Up-to-date anthropometric information of the U.S. truck driver population is needed for the design of safe and ergonomically efficient truck cabs. We collected 35 anthropometric dimensions for 1,950 truck drivers (1,779 males and 171 females) across the continental United States using a sampling plan designed to capture the appropriate ethnic, gender, and age distributions of the truck driver population. Truck drivers are heavier than the U.S.general population, with a difference in mean body weight of 13.5 kg for males and 15.4 kg for females. They are also different in physique from the U.S. general population. In addition, the current truck drivers are heavier and different in physique compared to their counterparts of 25 to 30 years ago. The data obtained in this study provide more accurate anthropometric information for cab designs than do the current U.S. general population data or truck driver data collected 25 to 30 years ago. Multivariate anthropometric models, spanning 95% of the current truck driver population on the basis of a set of 12 anthropometric measurements, have been developed to facilitate future cab designs. The up-to-date truck driver anthropometric data and multivariate anthropometric models will benefit the design of future truck cabs which, in turn, will help promote the safety and health of the U.S. truck drivers.

A randomized cross-over study comparing cabergoline and quinagolide in the treatment of hyperprolactinemic patients.

PubMed

De Luis, D A; Becerra, A; Lahera, M; Botella, J I; Valero; Varela, C

2000-01-01

Quinagolide (QUI) and cabergoline (CAB) are dopamine agonists recently introduced for the treatment of hyperprolactinemia. In the present study, these drugs have been compared in terms of effectiveness and tolerability. Twenty patients (18 females and 2 males) with hyperprolactinemia (8 with microprolactinomas, 6 with idiopathic hyperprolactinemia and 6 with empty sella turcica syndrome) were treated with oral QUI (75 microg once daily) and CAB (0,5 mg twice weekly), in a randomized cross-over trial with placebo between both drugs. Each drug was administered for 12 weeks, separated by other 12 weeks with placebo. PRL levels decreased with both drugs at 2 or 4 weeks of starting the treatment, without differences between both drugs at weeks 4, 8 and 12. At week 12, normal PRL levels (<20 ng/ml) were attained in 90% patients with CAB and only in 75% patients with QUI (p<0.05). After discontinuation of treatment, significant increase in serum PRL was higher after QUI withdrawal than after CAB. Clinical efficacy of both treatments was similar in terms of improvement amenorrhea, oligomenorrhea, galactorrhea, and impotence. All patients completed both cycles of treatment, and the most frequent side-effects were nausea, headache and dizziness, without significant differences between CAB (30%) and QUI (55%). Our study indicates that, at the doses employed here, CAB showed a high percentage of patients with normal PRL at the end of treatment and long-lasting efficacy in the levels of PRL. Clinical response and side-effects were similar in both drugs.

Measuring the Performance of Attention Networks with the Dalhousie Computerized Attention Battery (DalCAB): Methodology and Reliability in Healthy Adults.

PubMed

Jones, Stephanie A H; Butler, Beverly C; Kintzel, Franziska; Johnson, Anne; Klein, Raymond M; Eskes, Gail A

2016-01-01

Attention is an important, multifaceted cognitive domain that has been linked to three distinct, yet interacting, networks: alerting, orienting, and executive control. The measurement of attention and deficits of attention within these networks is critical to the assessment of many neurological and psychiatric conditions in both research and clinical settings. The Dalhousie Computerized Attention Battery (DalCAB) was created to assess attentional functions related to the three attention networks using a range of tasks including: simple reaction time, go/no-go, choice reaction time, dual task, flanker, item and location working memory, and visual search. The current study provides preliminary normative data, test-retest reliability (intraclass correlations) and practice effects in DalCAB performance 24-h after baseline for healthy young adults (n = 96, 18-31 years). Performance on the DalCAB tasks demonstrated Good to Very Good test-retest reliability for mean reaction time, while accuracy and difference measures (e.g., switch costs, interference effects, and working memory load effects) were most reliable for tasks that require more extensive cognitive processing (e.g., choice reaction time, flanker, dual task, and conjunction search). Practice effects were common and pronounced at the 24-h interval. In addition, performance related to specific within-task parameters of the DalCAB sub-tests provides preliminary support for future formal assessment of the convergent validity of our interpretation of the DalCAB as a potential clinical and research assessment tool for measuring aspects of attention related to the alerting, orienting, and executive control networks.

A new approach in gastroretentive drug delivery system using cholestyramine.

PubMed

Umamaheshwari, R B; Jain, Subheet; Jain, N K

2003-01-01

We prepared cellulose acetate butyrate (CAB)-coated cholestyramine microcapsules as a intragastric floating drug delivery system endowed with floating ability due to the carbon dioxide generation when exposed to the gastric fluid. The microcapsules also have a mucoadhesive property. Ion-exchange resin particles can be loaded with bicarbonate followed by acetohydroxamic acid (AHA) and coated with CAB by emulsion solvent evaporation method. The drug concentration was monitored to maintain the floating property and minimum effective concentration. The effect of CAB: drug-resin ratio (2:1, 4:1, 6:1 w/w) on the particle size, floating time, and drug release was determined. Cholestyramine microcapsules were characterized for shape, surface characteristics, and size distribution; cholestyramine/acetohydroxamic acid interactions inside microcapsules were investigated by X-ray diffractometry. The buoyancy time of CAB-coated formulations was better than that of uncoated resin particles. Also, a longer floating time was observed with a higher polymer:drug resin complex ratio (6:1). With increasing coating thickness the particle size was increased but drug release rate was decreased. The drug release rate was higher in simulated gastric fluid (SGF) than in simulated intestinal fluid (SIF). The in vivo mucoadhesion studies were performed with rhodamine-isothiocyanate (RITC) by fluorescent probe method. The amount of CAB-coated cholestyramine microcapsules that remained in the stomach was slightly lower than that of uncoated resin particles. Cholestyramine microcapsules were distributed throughout the stomach and exhibited prolonged gastric residence via mucoadhesion. These results suggest that CAB-coated microcapsules could be a floating as well as a mucoadhesive drug delivery system. Thus, it has promise in the treatment of Helicobacter pylori.

Evaluation of railroad cab car end beam designs.

DOT National Transportation Integrated Search

2003-06-01

This report presents the results of an experimental study to establish the strength and energy absorption capability of railroad cab car corner structures built to current requirements and for structures modified to carry higher loads and absorb more...

3. Missile transporter/erector, front of cab, erector fully extended, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Missile transporter/erector, front of cab, erector fully extended, view from left rear towards east - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

Tower-Related Major System Development Programs

DOT National Transportation Integrated Search

1978-03-01

This report is devoted to the present and near future states of the tower cab environment, addresses those MSDP systems which may have an impact on the current tower cab environment, systems and/or operations. The systems included are: Discrete Addre...

Identification and Categorization of Accidents and Injuries in Cabs of Locomotives

DOT National Transportation Integrated Search

1972-09-01

A review and categorization is made of available published locomotive cab accident reports and statistics, as well as of unpublished accident reports from a number of individual railroads. Major hazards related to locomotive control compartment accid...

The role of abdominal compliance, the neglected parameter in critically ill patients - a consensus review of 16. Part 1: definitions and pathophysiology.

PubMed

Malbrain, Manu L N G; Roberts, Derek J; De Laet, Inneke; De Waele, Jan J; Sugrue, Michael; Schachtrupp, Alexander; Duchesne, Juan; Van Ramshorst, Gabrielle; De Keulenaer, Bart; Kirkpatrick, Andrew W; Ahmadi-Noorbakhsh, Siavash; Mulier, Jan; Ivatury, Rao; Pracca, Francisco; Wise, Robert; Pelosi, Paolo

2014-01-01

Over the last few decades, increasing attention has been paid to understanding the pathophysiology, aetiology, prognosis, and treatment of elevated intra-abdominal pressure (IAP) in trauma, surgical, and medical patients. However, there is presently a relatively poor understanding of intra-abdominal volume (IAV) and the relationship between IAV and IAP (i.e. abdominal compliance). Consensus definitions on Cab were discussed during the 5th World Congress on Abdominal Compartment Syndrome and a writing committee was formed to develop this article. During the writing process, a systematic and structured Medline and PubMed search was conducted to identify relevant studies relating to the topic. According to the recently updated consensus definitions of the World Society on Abdominal Compartment Syndrome (WSACS), abdominal compliance (Cab) is defined as a measure of the ease of abdominal expansion, which is determined by the elasticity of the abdominal wall and diaphragm. It should be expressed as the change in IAV per change in IAP (mL [mm Hg]⁻¹). Importantly, Cab is measured differently than IAP and the abdominal wall (and its compliance) is only a part of the total abdominal pressure-volume (PV) relationship. During an increase in IAV, different phases are encountered: the reshaping, stretching, and pressurisation phases. The first part of this review article starts with a comprehensive list of the different definitions related to IAP (at baseline, during respiratory variations, at maximal IAV), IAV (at baseline, additional volume, abdominal workspace, maximal and unadapted volume), and abdominal compliance and elastance (i.e. the relationship between IAV and IAP). An historical background on the pathophysiology related to IAP, IAV and Cab follows this. Measurement of Cab is difficult at the bedside and can only be done in a case of change (removal or addition) in IAV. The Cab is one of the most neglected parameters in critically ill patients, although it plays a key role in understanding the deleterious effects of unadapted IAV on IAP and end-organ perfusion. The definitions presented herein will help to understand the key mechanisms in relation to Cab and clinical conditions and should be used for future clinical and basic science research. Specific measurement methods, guidelines and recommendations for clinical management of patients with low Cab are published in a separate review.

48 CFR 42.702 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... estimated rates subject to adjustment during contract performance and at the time the final indirect cost....702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT... under this subpart provides— (1) Uniformity of approach with a contractor when more than one contract or...

48 CFR 42.702 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... estimated rates subject to adjustment during contract performance and at the time the final indirect cost....702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT... under this subpart provides— (1) Uniformity of approach with a contractor when more than one contract or...

Advanced Transportation System Studies Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development Contract. Volume 2; Technical Results

NASA Technical Reports Server (NTRS)

1995-01-01

The purpose of the Advanced Transportation System Studies (ATSS) Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. This document is Volume 2 of the final report for the contract. It provides documentation of selected technical results from various TA-2 analysis activities, including a detailed narrative description of the SSTO concept assessment results, a user's guide for the associated SSTO sizing tools, an SSTO turnaround assessment report, an executive summary of the ground operations assessments performed during the first year of the contract, a configuration-independent vehicle health management system requirements report, a copy of all major TA-2 contract presentations, a copy of the FLO launch vehicle final report, and references to Pratt & Whitney's TA-2 sponsored final reports regarding the identification of Russian main propulsion technologies.

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

49 CFR 236.714 - Cab.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.714 Cab. The compartment of a locomotive from which the propelling power and power brakes of the train are manually...

Modeling material failure during cab car end frame impact

DOT National Transportation Integrated Search

2009-03-03

New standards have been proposed to increase the strength requirements for cab car end structures and impose further requirements on their ability to absorb energy during a grade-crossing collision. This conference paper reports on a set of full-scal...

Mergers and Anti-trust Issues in Recent CAB Cases

NASA Technical Reports Server (NTRS)

Andrews, A. M.

1972-01-01

The airline industry is surveyed-particularly domestic trunklines-in relation to collective approaches to industry concerns. These actions are classified by the apparent degree of anti-trust issue present. Recent route merger cases are considered from the CAB staff viewpoint.

Air flow testing on aerodynamic truck

NASA Technical Reports Server (NTRS)

1975-01-01

After leasing a cab-over tractor-trailer from a Southern California firm, Dryden researchers added sheet metal modifications like those shown here. They rounded the front corners and edges, and placed a smooth fairing on the cab's roofs and sides extending back to the trailer. During the investigation of truck aerodynamics, the techniques honed in flight research proved highly applicable. By closing the gap between the cab and the trailer, for example, researchers discovered a significant reduction in aerodynamic drag, one resulting in 20 to 25 percent less fuel consumption than the standard design. Many truck manufacturers subsequently incorporated similar modifications on their products.

Improvement of CO2/N2 separation performance by polymer matrix cellulose acetate butyrate

NASA Astrophysics Data System (ADS)

Lee, R. J.; Jawad, Z. A.; Ahmad, A. L.; Ngo, J. Q.; Chua, H. B.

2017-06-01

With the rapid development of modern civilization, carbon dioxide (CO2) is produced in large quantities and mainly generated from industrial sectors. The gas emission is the major contributor to global warming. To address this issue, the membrane technology is implemented for the CO2 removal, due to the energy efficiency and economic advantages presented. Cellulose acetate butyrate (CAB) is selected as the polymeric material, due to the excellent film-forming properties and capable of developing a defect-free layer of neat membrane. This study described the fabrication development of CAB using a wet phase inversion method with different casting conditions. Where the composition of the casting solutions (3-5 wt %) and solvent evaporation time (4-6 min) were determined. The outcomes of these dominant parameters were then used to determine the best CAB membrane for CO2/Nitrogen (N2) separation and supported by the characterization i.e. scanning electron micrograph. Gas permeation measurements showed satisfactory performance for CAB membrane fabricated with 5 min evaporation time and 4 wt% polymer composition (M2). Where, its permeance and selectivity are 120.19 GPU and 3.17, respectively. In summary, this study showed a brief outlined of the future direction and perspective of CAB membrane for CO2/N2 separation.

Pathogenesis of Potassium-Competitive Acid Blocker-Resistant Non-Erosive Reflux Disease.

PubMed

Kawami, Noriyuki; Hoshino, Shintaro; Hoshikawa, Yoshimasa; Takenouchi, Nana; Umezawa, Mariko; Hanada, Yuriko; Kaise, Mitsuru; Iwakiri, Katsuhiko

2018-06-05

The present study examined the pathogenesis of potassium-competitive acid blocker (P-CAB)-resistant non-erosive reflux disease (NERD). Forty-three patients with NERD, who had persistent reflux symptoms despite the administration of P-CAB, were included in this study. After excluding eosinophilic esophagitis and primary esophageal motility disorders, esophageal impedance-pH monitoring was performed. In symptom index (SI)-positive patients, the mechanism of SI-positivity and percent time with intragastric pH > 4 and with esophageal pH < 4 were investigated according to the presence or absence of Helicobacter pylori infection. One (2.3%) of 43 patients had a primary esophageal motility disorder (Jackhammer esophagus). Eighteen (41.9%) and 3 (7%) patients were SI-positive for liquid and gas-only reflux, respectively, and the remaining 21 patients who were SI-negative (48.8%) had functional heartburn. All patients SI-positive for liquid reflux were SI-positive for weakly acidic reflux. Gastric acid was sufficiently suppressed by P-CAB, regardless of the presence or absence of H. pylori infection. The pathogenesis of -P-CAB-resistant NERD was elucidated in 51% of patients. Symptoms in all patients SI-positive for liquid reflux were related to weakly acidic reflux, and symptoms related to acid reflux may be ruled out by the administration of P-CAB. © 2018 S. Karger AG, Basel.

48 CFR 242.705 - Final indirect cost rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Final indirect cost rates. 242.705 Section 242.705 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 242...

Federal employees health benefits acquisition regulation: Board of Contract Appeals. Final rule.

PubMed

2008-10-08

The Office of Personnel Management (OPM) is adopting as final,without change, the proposed rule published April 7, 2008 to remove the designation of the Armed Services Board of Contract Appeals (ASBCA)from the Federal Employees Health Benefits Acquisition Regulation(FEHBAR).

Prototype design and test of a collision protection system for cab car engineers.

DOT National Transportation Integrated Search

2014-12-01

Advancements in the design of rail cars can : potentially prevent the structural collapse of : space occupied by a cab car engineer : during a train collision. With adequate : survival space maintained, the next : crashworthiness objective is to mini...

Rail vehicle cab car collision and corner post designs according to APTA-S-034 requirements

DOT National Transportation Integrated Search

2003-11-16

The American Public Transportation Association standard for rail passenger equipment, S-034, includes requirements for the collision and corner posts of cab cars that are consistent with new federal requirements and substantially different than what ...

Prototype design of a collision protection system for cab car engineers - fabrication and test.

DOT National Transportation Integrated Search

2015-06-01

Advancements in the structural crashworthiness of passenger rail cars now make it possible to preserve the compartmentalized : space occupied by a cab car engineer during a train collision. In order to translate this additional protection into improv...

The Antarctic permafrost as a testbed for REMS (Rover Environmental Monitoring Station-Mars Science Laboratory)

NASA Astrophysics Data System (ADS)

Esteban, B.; Ramos, M.; Sebastián, E.; Armiens, C.; Gómez-Elvira, J.; Cabos, W.; de Pablo, M. A.

2009-04-01

The present climatic characteristics of Mars favor the presence of extense permafrost areas in this lonely planet. Therefore environmental parameters that are included in Martian Rover missions are also used for monitoring thermal soil surface evolution in order to study the permafrost active layer thickness and the energy balance in the soil-atmosphere boundary limit layer. The REMS (Rover Environmental Monitoring Station) is an environmental station designed by the Centro de Astrobiología (CAB- Spain) with the collaboration of national and international partners (CRISA/EADS, UPC and FMI), which is part of the payload of the MSL (Mars Science Laboratory) NASA mission to Mars (http://mars.jpl.nasa.gov/msl/overview/). This mission is expected to be launched in the final months of 2009, and mainly consists of a Rover, with a complete set of scientific instruments; the Rover will carry the biggest, most advanced suite of instruments for scientific studies ever sent to the Martian surface. Five sensors compose the REMS instrument: ground (GT-REMS) and air temperatures, wind speed and direction, pressure, humidity and ultraviolet radiation (UV-REMS). A simplified setup of the REMS was deployed on Antarctica in the surroundings of the Spanish Antarctic Stations on Livingston and Deception Islands (Maritime Antarctica), where the permafrost distribution is well-known. The aim of the experiment was to check REMS's sensors response against hard environmental conditions and calibrates their measures with standard Antarctic devices. The experimental apparatuses included some standard meteorological and thermopiles sensors corresponding to the REMS. All the sensors are mounted in a 1.8 m mast and include a Pt100 air temperature sensor with shield solar protection on the mast top, a Kipp and Zonnen CNR1 net radiometer for measuring infrared (5-50 μm) and short wave solar (305-2800 nm) radiation at 1.5 m high, GT-REMS sensor and its amplification box at 0.7 m high and finally two soil temperature plates based on Pt100 sensors are in close contact with the surface in the angle of view of the GT-REMS thermopiles. In this work, we present a preliminary analysis of the data obtained in the Antarctic field campaign 2008-2009. For the analysis we developed a theoretical model which is briefly outlined here. We also present the results of simulations carried out with the model and their validation against the antarctic data. Complementary to the Antarctic experiments, we carried out an experience with all the instruments during the last summer in the CAB-Spain which are also used in the analysis. Finally, we compare the results of the last polar and CAB experiments in order to check the improvements introduced in GT-REMS.

Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence.

PubMed

Calder, Thomas; de Souza Santos, Marcela; Attah, Victoria; Klimko, John; Fernandez, Jessie; Salomon, Dor; Krachler, Anne-Marie; Orth, Kim

2014-12-01

The Gram-negative bacterium, Vibrio parahaemolyticus, is a major cause of seafood-derived food poisoning throughout the world. The pathogenicity of V. parahaemolyticus is attributed to several virulence factors, including two type III secretion systems (T3SS), T3SS1 and T3SS2. Herein, we compare the virulence of V. parahaemolyticus POR strains, which harbor a mutation in the T3SS needle apparatus of either system, to V. parahaemolyticus CAB strains, which harbor mutations in positive transcriptional regulators of either system. These strains are derived from the clinical RIMD 2210633 strain. We demonstrate that each mutation affects the virulence of the bacterium in a different manner. POR and CAB strains exhibited similar levels of swarming motility and T3SS effector production and secretion, but the CAB3 and CAB4 strains, which harbor a mutation in the T3SS2 master regulator gene, formed reduced biofilm growth under T3SS2 inducing conditions. Additionally, while the cytotoxicity of the POR and CAB strains was similar, the CAB2 (T3SS1 regulatory mutant) strain was strikingly more invasive than the comparable POR2 (T3SS1 structural mutant) strain. In summary, creating structural or regulatory mutations in either T3SS1 or T3SS2 causes differential downstream effects on other virulence systems. Understanding the biological differences of strains created from a clinical isolate is critical for interpreting and understanding the pathogenic nature of V. parahaemolyticus. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Study for every other day administration of vonoprazan in maintenance treatment of erosive GERD: study protocol for a multicentre randomised cross-over study.

PubMed

Kato, Mototsugu; Ito, Noriko; Demura, Mamiko; Kubo, Kimitoshi; Mabe, Katsuhiro; Harada, Naohiko

2018-01-01

The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected. This study is a prospective, multicentre, open-label, two-period randomised cross-over study to compare the efficacy and safety of PPI every other day administration and P-CAB every other day administration in 120 patients who receive erosive GERD maintenance therapy with PPI. Patients will be randomly allocated to receive 4 weeks P-CAB or PPI followed by 4 weeks cross over, where those on P-CAB will receive PPI and vice versa. The primary endpoint is proportion of asymptomatic patients. Secondary endpoints are suppressive effect of GERD symptoms, proportion of asymptomatic patients at each time point, safety and cost-saving effect of P-CAB every other day administration, compliance with every other day administration, and proportion of asymptomatic patients at the first month of study drug administration. This study was approved by the National Hospital Organization Central Review Board for Clinical Trials (5 December 2017). If P-CAB every other day administration is established as one of GERD maintenance therapies, there is merit in both medical cost reduction and the safety to alleviate elevation in serum gastrin. UMIN000034701.

Study for every other day administration of vonoprazan in maintenance treatment of erosive GERD: study protocol for a multicentre randomised cross-over study

PubMed Central

Kato, Mototsugu; Ito, Noriko; Demura, Mamiko; Kubo, Kimitoshi; Mabe, Katsuhiro; Harada, Naohiko

2018-01-01

Introduction The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected. Methods and analysis This study is a prospective, multicentre, open-label, two-period randomised cross-over study to compare the efficacy and safety of PPI every other day administration and P-CAB every other day administration in 120 patients who receive erosive GERD maintenance therapy with PPI. Patients will be randomly allocated to receive 4 weeks P-CAB or PPI followed by 4 weeks cross over, where those on P-CAB will receive PPI and vice versa. The primary endpoint is proportion of asymptomatic patients. Secondary endpoints are suppressive effect of GERD symptoms, proportion of asymptomatic patients at each time point, safety and cost-saving effect of P-CAB every other day administration, compliance with every other day administration, and proportion of asymptomatic patients at the first month of study drug administration. Ethics and dissemination This study was approved by the National Hospital Organization Central Review Board for Clinical Trials (5 December 2017). Discussion If P-CAB every other day administration is established as one of GERD maintenance therapies, there is merit in both medical cost reduction and the safety to alleviate elevation in serum gastrin. Trial registration number UMIN000034701. PMID:29527318

Suppression of calbindin-D28k expression exacerbates SCA1 phenotype in a disease mouse model.

PubMed

Vig, Parminder J S; Wei, Jinrong; Shao, Qingmei; Lopez, Maripar E; Halperin, Rebecca; Gerber, Jill

2012-09-01

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurological disorder caused by the expansion of a polyglutamine tract in the mutant protein ataxin-1. The cerebellar Purkinje cells (PCs) are the major targets of mutant ataxin-1. The mechanism of PC death in SCA1 is not known; however, previous work indicates that downregulation of specific proteins involved in calcium homeostasis and signaling by mutant ataxin-1 is the probable cause of PC degeneration in SCA1. In this study, we explored if targeted deprivation of PC specific calcium-binding protein calbindin-D28k (CaB) exacerbates ataxin-1 mediated toxicity in SCA1 transgenic (Tg) mice. Using behavioral tests, we found that though both SCA1/+ and SCA1/+: CaB null (-/+) double mutants exhibited progressive impaired performance on the rotating rod, a simultaneous enhancement of exploratory activity, and absence of deficits in coordination, the double mutants were more severely impaired than SCA1/+ mice. With increasing age, SCA1/+ mice showed a progressive loss in the expression and localization of CaB and other PC specific calcium-binding and signaling proteins. In double mutants, these changes were more pronounced and had an earlier onset. Gene expression profiling of young mice exhibiting no behavior or biochemical deficits revealed a differential expression of many genes common to SCA1/+ and CaB-/+ lines, and unique to SCA1/+: CaB-/+ phenotype. Our study provides further evidence for a critical role of CaB in SCA1 pathogenesis, which may help identify new therapeutic targets to treat SCA1 or other cerebellar ataxias.

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracts for research and development. (d) Use the clause at 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and development. (e) Use the clause at 252.235-7004...

76 FR 43571 - Small Business HUBZone Program; Government Contracting Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 126 RIN 3245-AG45 Small Business HUBZone Program; Government Contracting Programs AGENCY: U.S. Small Business Administration. ACTION: Interim final rule with request for comments. SUMMARY: This interim final rule amends the U.S. Small Business Administration's...

48 CFR 552.219-74 - Section 8(a) Direct Award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting activity shall give advance notice to SBA before it issues a final notice terminating performance... prior to processing any advance payments or novation agreements. The contracting activity may assign contract administration functions to a contract administration office. (c) The Contractor agrees: (1) To...

Locomotive cab design development. Volume 5 : performance evaluation tests

DOT National Transportation Integrated Search

1976-09-01

This document reports on a preiiminary evaluation o f the Buman : Factors design proposed for a line haul freight locomotive : cab . The program was conducted using a full scale hard mock-up : o f the proposed design and the evaluation was provided b...

A numerical evaluation of protection strategies for cab car crashworthiness

DOT National Transportation Integrated Search

1999-11-15

The operator and passengers in cab cars are particularly vulnerable to collisions with objects or with other trains because of their proximity to the point of collision. We present one part of a larger study in which we examined several strategies fo...

Rail-car impact tests with steel coil: collision dynamics

DOT National Transportation Integrated Search

2003-04-22

Two full-scale oblique grade-crossing impact tests were conducted in June 2002 to compare the crashworthiness performance of alternative corner post designs on rail passenger cab cars. On June 4, 2002 a cab car fitted with an end structure built to p...

Development of conventional passenger cab car end structure designs for full scale testing

DOT National Transportation Integrated Search

2006-12-01

The Volpe Center is supporting the Federal Railroad Administration's full-scale testing program to understand and improve rail vehicle cashworthiness. The objectie of one of the sets of tests in this program is determining the behavior of cab car end...

Risk management. National Aeronautics and Space Administration (NASA). Interim rule adopted as final with changes.

PubMed

2000-11-22

This is a final rule amending the NASA FAR Supplement (NFS) to emphasize considerations of risk management, including safety, security (including information technology security), health, export control, and damage to the environment, within the acquisition process. This final rule addresses risk management within the context of acquisition planning, selecting sources, choosing contract type, structuring award fee incentives, administering contracts, and conducting contractor surveillance.

77 FR 75780 - Nondisplacement of Qualified Workers Under Service Contracts; Effective Date

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... of Qualified Workers Under Service Contracts; Effective Date AGENCY: Wage and Hour Division, Department of Labor. ACTION: Final rule; notice of effective date and OMB approval of information collection requirements. SUMMARY: The Department of Labor announces the effective date of its Final Rule published on...

48 CFR 42.707 - Cost-sharing rates and limitations on indirect cost rates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... final indirect cost rate ceiling in a contract. Examples of such circumstances are when the proposed... ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42... authorized, may call for the contractor to participate in the costs of the contract by accepting indirect...

Evaluation of contract time estimation and contracting procedures for louisiana department of transportation and development construction projects : final report : volume I.

DOT National Transportation Integrated Search

1995-09-11

The purpose of the research was to provide the Louisiana Department of Transportation and Development (LaDOTD) with a systematic approach to the determination of contract time and to explore innovative contracting procedures that may prove beneficial...

42 CFR 423.643 - Effect of contract determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of contract determination. 423.643 Section 423.643 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Determinations and Appeals § 423.643 Effect of contract determination. The contract determination is final and...

42 CFR 422.646 - Effect of contract determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of contract determination. 422.646 Section 422.646 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Appeals § 422.646 Effect of contract determination. The contract determination is final and binding unless...

78 FR 7821 - Public Availability of Railroad Retirement Board FY 2012 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

.../files/omb/procurement/memo/service-contract-inventory-guidance.pdf . The Railroad Retirement Board has... analysis of its selected special interest functions from the FY 2012 Service Contract inventory, and finally (4) the analysis report on its FY 2011 Service Contract Inventory special interest functions, on...

Cost and Schedule Analytical Techniques Development

NASA Technical Reports Server (NTRS)

1998-01-01

This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) under contract NAS 8-40431 "Cost and Schedule Analytical Techniques Development Contract" (CSATD) during Option Year 3 (December 1, 1997 through November 30, 1998). This Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides technical products and deliverables in the form of parametric models, databases, methodologies, studies, and analyses to the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PP03) and the Program Plans and Requirements Office (PP02) and other user organizations. Detailed Monthly Reports were submitted to MSFC in accordance with the contract's Statement of Work, Section IV "Reporting and Documentation". These reports spelled out each month's specific work performed, deliverables submitted, major meetings conducted, and other pertinent information. Therefore, this Final Report will summarize these activities at a higher level. During this contract Option Year, SAIC expended 25,745 hours in the performance of tasks called out in the Statement of Work. This represents approximately 14 full-time EPs. Included are the Huntsville-based team, plus SAIC specialists in San Diego, Ames Research Center, Tampa, and Colorado Springs performing specific tasks for which they are uniquely qualified.

Airport Shared-Ride Taxi Programs in New York, Chicago and Boston

DOT National Transportation Integrated Search

1987-12-01

This report summarizes the development and operation of three shared-ride taxi operations at major U.S. airports. These are: New York's LaGuardia Airport Share-A-Cab; Super Saver Taxi in Chicago; and Share-A-Cab service at Boston's Logan Airport. The...

49 CFR 236.534 - Entrance to equipped territory; requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.534... not exceed restricted speed, the automatic train stop, train control, or cab signal device shall be...

49 CFR 236.526 - Roadway element not functioning properly.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.526 Roadway..., train control or cab signal system is not functioning as intended, the signal associated with such...

49 CFR 236.534 - Entrance to equipped territory; requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.534... not exceed restricted speed, the automatic train stop, train control, or cab signal device shall be...

49 CFR 236.526 - Roadway element not functioning properly.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.526 Roadway..., train control or cab signal system is not functioning as intended, the signal associated with such...

49 CFR 236.587 - Departure test.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.587 Departure test. (a) The automatic train stop, train control, or cab signal apparatus on each locomotive, except a locomotive or a...

21 CFR 26.36 - Listing of CAB's.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Listing of CAB's. 26.36 Section 26.36 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS...

Review of severe deformation recommended practice through analyses - comparison of two cab car end frame designs

DOT National Transportation Integrated Search

2005-03-16

Non-linear large deformation analyses have been conducted : to evaluate the performance of the cab car corner and collision : posts of the Federal Railroad Administration's (FRA) : sponsored state-of-the-art (SOA) end frame design and the : Bombardie...

49 CFR 236.516 - Power supply.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Power supply. 236.516 Section 236.516..., Train Control and Cab Signal Systems Standards § 236.516 Power supply. Automatic cab signal, train stop, or train control device hereafter installed shall operate from a separate or isolated power supply...

49 CFR 236.516 - Power supply.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Power supply. 236.516 Section 236.516..., Train Control and Cab Signal Systems Standards § 236.516 Power supply. Automatic cab signal, train stop, or train control device hereafter installed shall operate from a separate or isolated power supply...

49 CFR 229.115 - Slip/slide alarms.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Cabs and Cab Equipment § 229.115 Slip/slide alarms. (a) Except for MU locomotives, each locomotive used in road service shall... road service, or continue in road service following a daily inspection, unless the wheel slip/slide...

49 CFR 229.115 - Slip/slide alarms.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Cabs and Cab Equipment § 229.115 Slip/slide alarms. (a) Except for MU locomotives, each locomotive used in road service shall... road service, or continue in road service following a daily inspection, unless the wheel slip/slide...

49 CFR 236.590 - Pneumatic apparatus.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Pneumatic apparatus. 236.590 Section 236.590..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.590 Pneumatic apparatus. Automatic train stop, train control, or cab signal pneumatic apparatus shall be inspected, cleaned, and the...

49 CFR 236.590 - Pneumatic apparatus.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Pneumatic apparatus. 236.590 Section 236.590..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.590 Pneumatic apparatus. Automatic train stop, train control, or cab signal pneumatic apparatus shall be inspected, cleaned, and the...

10. DETAIL, CAB SIDE. DETAIL, END OF BOOM. DETAIL, LOWER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. DETAIL, CAB SIDE. DETAIL, END OF BOOM. DETAIL, LOWER PART OF TOWER, SHOWING METAL WHEELS AND CABLE SPOOLS. DETAIL, LOOKING UP AT THE UNDERSIDE OF THE REVOLVING PLATFORM ATOP THE TOWER. - United Engineering Company Shipyard, Crane, 2900 Main Street, Alameda, Alameda County, CA

Changes in neuroendocrine elements in bronchial mucosa in chronic lung disease in adults.

PubMed

Pilmane, M; Luts, A; Sundler, F

1995-05-01

It is not clear whether there is any association between metaplasia of the bronchial epithelium and changes in the distribution of neuroendocrine cells. This study examined, by immunohistological techniques, the distribution of neuroendocrine cells and juxtamucoscal nerve fibres in bronchial biopsies showing metaplastic changes. Bronchial biopsies from 12 subjects with epithelial metaplasia associated with bronchiectasis and diffuse pulmonary fibrosis were examined by conventional light microscopy and immunohistological techniques for protein gene product 9.5 (PGP), chromogranin A and B (CAB), serotonin, vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), calcitonin (CT), and gastrin releasing peptide (GRP). Regions of non-metaplastic epithelium contained numerous PGP and serotonin immunoreactive cells. Sub-populations of these cells displayed CAB, CGRP, CT, and GRP immunoreactivity. Metaplastic epithelium contained only a few weakly stained PGP, serotonin, CAB, GRP, CT and CGRP immunoreactive cells in six cases. Metaplastic epithelium was characterised by a high number of CAB-containing cells in six cases and in these biopsies prominent PGP-containing nerve bundles were seen in the subepithelial layer beneath the metaplastic epithelium. The distribution patterns of neuroendocrine cells and neuronal elements vary between areas of normal and metaplastic epithelium and within areas of metaplastic epithelium. Neuronal hyperplasia was associated with an increase in the number of CAB-containing cells within the metaplastic epithelium.

Changes in neuroendocrine elements in bronchial mucosa in chronic lung disease in adults.

PubMed Central

Pilmane, M.; Luts, A.; Sundler, F.

1995-01-01

BACKGROUND--It is not clear whether there is any association between metaplasia of the bronchial epithelium and changes in the distribution of neuroendocrine cells. This study examined, by immunohistological techniques, the distribution of neuroendocrine cells and juxtamucoscal nerve fibres in bronchial biopsies showing metaplastic changes. METHODS--Bronchial biopsies from 12 subjects with epithelial metaplasia associated with bronchiectasis and diffuse pulmonary fibrosis were examined by conventional light microscopy and immunohistological techniques for protein gene product 9.5 (PGP), chromogranin A and B (CAB), serotonin, vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), calcitonin (CT), and gastrin releasing peptide (GRP). RESULTS--Regions of non-metaplastic epithelium contained numerous PGP and serotonin immunoreactive cells. Sub-populations of these cells displayed CAB, CGRP, CT, and GRP immunoreactivity. Metaplastic epithelium contained only a few weakly stained PGP, serotonin, CAB, GRP, CT and CGRP immunoreactive cells in six cases. Metaplastic epithelium was characterised by a high number of CAB-containing cells in six cases and in these biopsies prominent PGP-containing nerve bundles were seen in the subepithelial layer beneath the metaplastic epithelium. CONCLUSIONS--The distribution patterns of neuroendocrine cells and neuronal elements vary between areas of normal and metaplastic epithelium and within areas of metaplastic epithelium. Neuronal hyperplasia was associated with an increase in the number of CAB-containing cells within the metaplastic epithelium. Images PMID:7541167

Evaluation of EA-934NA with 2.5 percent Cab-O-Sil

NASA Technical Reports Server (NTRS)

Caldwell, Gordon A.

1990-01-01

Currently, Hysol adhesive EA-934NA is used to bond the Field Joint Protection System on the Shuttle rocket motors at Kennedy Space Center. However, due to processing problems, an adhesive with a higher viscosity is needed to alleviate these difficulties. One possible solution is to add Cab-O-Sil to the current adhesive. The adhesive strength and bond strengths that can be obtained when 2.5 percent Cab-O-Sil is added to adhesive EA-934NA are examined and tested over a range of test temperatures from -20 to 300 F. Tensile adhesion button and lap shear specimens were bonded to D6AC steel and uniaxial tensile specimens (testing for strength, initial tangent modulus, elongation and Poisson's ratio) were prepared using Hysol adhesive EA-934NA with 2.5 percent Cab-O-Sil added. These specimens were tested at -20, 20, 75, 100, 125, 150, 200, 250, and 300 F, respectively. Additional tensile adhesion button specimens bonding Rust-Oleum primed and painted D6AC steel to itself and to cork using adhesive EA-934NA with 2.5 percent Cab-O-Sil added were tested at 20, 75, 125, 200, and 300 F, respectively. Results generally show decreasing strength values with increasing test temperatures. The bond strengths obtained using cork as a substrate were totally dependent on the cohesive strength of the cork.

Decreases in collision risk and derailments attributed to changing at-risk behavior process at Union Pacific.

DOT National Transportation Integrated Search

2009-09-01

Changing At-Risk Behavior (CAB) is a safety process that is being conducted at Union Pacifics San Antonio Service Unit (SASU) with the aim of improving road and yard safety. CAB is an example of a proactive safety risk-reduction method, called Cle...

49 CFR 236.586 - Daily or after trip test.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.586 Daily or after trip test..., each locomotive equipped with an automatic cab signal or train stop or train control device operating...

49 CFR 236.588 - Periodic test.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.588 Periodic test. Except as provided in § 236.586, periodic test of the automatic train stop, train control, or cab signal apparatus...

49 CFR 236.509 - Two or more locomotives coupled.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.509 Two or more locomotives coupled. The automatic train stop, train control or cab signal apparatus shall be arranged so that when two or...

49 CFR 236.557 - Receiver; location with respect to rail.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Locomotives § 236.557 Receiver... automatic cab signal, train stop, or train control device of locomotive equipped with onboard test equipment...

49 CFR 236.586 - Daily or after trip test.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.586 Daily or after trip test..., each locomotive equipped with an automatic cab signal or train stop or train control device operating...

49 CFR 236.509 - Two or more locomotives coupled.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.509 Two or more locomotives coupled. The automatic train stop, train control or cab signal apparatus shall be arranged so that when two or...

41 CFR 101-26.501-2 - Standardized buying programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and 6×4 cab-chassis, stake, van, dump, and truck-tractor; 19,000 to 60,000 pounds GVWR. (ii) 4×4 and 6×4 cab-chassis, stake, dump, and truck-tractor; 26,000 to 52,000 pounds GVWR. (iii) 1,200 and 2,000...

49 CFR 236.514 - Interconnection of cab signal system with roadway signal system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Interconnection of cab signal system with roadway signal system. 236.514 Section 236.514 Transportation Other Regulations Relating to Transportation... GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES...

49 CFR 236.588 - Periodic test.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Periodic test. 236.588 Section 236.588..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.588 Periodic test. Except as provided in § 236.586, periodic test of the automatic train stop, train control, or cab signal apparatus...

49 CFR 236.588 - Periodic test.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Periodic test. 236.588 Section 236.588..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.588 Periodic test. Except as provided in § 236.586, periodic test of the automatic train stop, train control, or cab signal apparatus...

2008 Tactical Wheeled Vehicles Conference (TWV) Volume 1

DTIC Science & Technology

2008-02-05

additional LSAC cabs FMTV Gunners Restraint (2,022 LSAC; 1,855 RACK) Counterweight bumper for M1078 Cargo with LSAC Cab and GPK 3 Jan 08NDIA TWV Conference...Objective Gunner Protection Kits to support Up-Armored HMMWV’s GPK Upgrade Program. Partnerships: Ensured partnerships with commercial manufacturers

Themes Found in High Performing Schools: The CAB Model

ERIC Educational Resources Information Center

Sanders, Brenda

2010-01-01

This study examines the CAB [Cooperativeness, Accountability, and Boundlessness] model of high performing schools by developing case studies of two Portland, Oregon area schools. In pursuing this purpose, this study answers the following three research questions: 1) To what extent is the common correlate cooperativeness demonstrated or absent in…

Train-to-Train Impact Test of Crash-Energy Management Passenger Rail Equipment: Structural Results

DOT National Transportation Integrated Search

2006-01-01

On March 23, 2006, a full-scale test was conducted on a : passenger rail train retrofitted with newly developed cab end : and non-cab end crush zone designs. This test was conducted : as part of a larger testing program to establish the degree of : e...

48 CFR 16.403 - Fixed-price incentive contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... relationship of total final negotiated cost to total target cost. The final price is subject to a price ceiling, negotiated at the outset. The two forms of fixed-price incentive contracts, firm target and successive targets, are further described in 16.403-1 and 16.403-2 below. (b) Application. A fixed-price incentive...

48 CFR 16.403 - Fixed-price incentive contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... relationship of total final negotiated cost to total target cost. The final price is subject to a price ceiling, negotiated at the outset. The two forms of fixed-price incentive contracts, firm target and successive targets, are further described in 16.403-1 and 16.403-2 below. (b) Application. A fixed-price incentive...

76 FR 13329 - Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building Services

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

..., Release of Claims, for releases of claims under construction and building service contracts, was... prescribed the use of GSA Form 1142 for releases of claims under construction and building service contracts...] RIN 3090-AJ13 Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building...

77 FR 26763 - General Services Administration Acquisition Regulation; Submission for OMB Review; Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... Claims, regarding final payment under construction and building services contract. GSA Form 1142 was... construction and building services contractors to submit a release of claims before final payment is made to... (GSAR Parts 532 and 552.232-72; GSA Form 1142 Release of Claims) AGENCY: Office of the Chief Acquisition...

Report on the Audit of Architect-Engineer Contracting at U.S. Army Engineer Division, Europe

DTIC Science & Technology

1991-02-13

This is our final report on the Audit of Architect-Engineer Contracting at U.S. Army Engineer Division1 Europe, for your information and use...our ongoing audit of architect-engineer contracting. The Contract Management Directorate made the audit from March 1989 through February 1990. The audit covered

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

Advanced transportation system studies technical area 2 (TA-2): Heavy lift launch vehicle development. volume 3; Program Cost estimates

NASA Technical Reports Server (NTRS)

McCurry, J. B.

1995-01-01

The purpose of the TA-2 contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. The basic period of performance of the TA-2 contract was from May 1992 through May 1993. No-cost extensions were exercised on the contract from June 1993 through July 1995. This document is part of the final report for the TA-2 contract. The final report consists of three volumes: Volume 1 is the Executive Summary, Volume 2 is Technical Results, and Volume 3 is Program Cost Estimates. The document-at-hand, Volume 3, provides a work breakdown structure dictionary, user's guide for the parametric life cycle cost estimation tool, and final report developed by ECON, Inc., under subcontract to Lockheed Martin on TA-2 for the analysis of heavy lift launch vehicle concepts.

Performance-Based Logistics Contracts: A Basic Overview

DTIC Science & Technology

2005-11-01

world. The Navy began using PBL contracts in 1999, and since then, contract managers have reported improved availability and reduced customer wait...4825 Mark Center Drive • Alexandria, Virginia 22311-1850 CRM D0012881.A2/Final November 2005 Performance-Based Logistics Contracts: A Basic Overview...Performance-Based Logistics (PBL) contracts provide services or sup- port where the provider is held to customer -oriented performance requirements

Improved safety culture and labor-management relations attributed to changing at-risk behavior process at Union Pacific.

DOT National Transportation Integrated Search

2009-09-01

Changing At-Risk Behavior (CAB) is a safety process that is being conducted at Union Pacifics San Antonio Service Unit (SASU) with the aim of improving road and yard safety. CAB is an example of a proactive safety risk-reduction method called Clea...

Fabrication of Tunable Submicro- or Nano-structured Polyethylene Materials form Immiscible Blends with Cellulose Acetate Butyrate

USDA-ARS?s Scientific Manuscript database

Low density polyethylene (LDPE) was prepared into micro- or submicro-spheres or nanofibers via melt blending or extrusion of cellulose acetate butyrate (CAB)/LDPE immiscible blends and subsequent removal of the CAB matrix. The sizes of the PE spheres or fibers can be successfully controlled by varyi...

Heavy vehicle driver workload assessment. Task 7A, in-cab text message system and cellular phone use by heavy vehicle drivers on road

DOT National Transportation Integrated Search

This report covers the seventh in a series of tasks involving the assessment of driver workload in heavy vehicle operation associated with in-cab devices or systems. This report addresses the application of a workload assessment protocol and measurem...

KSC-04PD-1042

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- STS-114 Mission Specialist Andrew Thomas takes a look inside one of the cabs on a Crawler- Transporter. The crawlers had recent modifications to the cab and muffler system. The STS-114 mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.

PubMed

Innocenti, Alessio; Zimmerman, Sabrina A; Scozzafava, Andrea; Ferry, James G; Supuran, Claudiu T

2008-12-01

Activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases (CAs, EC 4.2.1.1) with a series of natural and non-natural amino acids and aromatic/heterocyclic amines has been investigated. Cab, Zn-Cam and Co-Cam showed an activation profile with natural, L- and D-amino acids very different of those of the alpha-class enzymes CA I, II and III. Most of these compounds showed medium efficacy as archaeal CA activators, except for D-Phe and L-Tyr which were effective Cab activators (K(A)s of 10.3-10.5 microM), 2-pyridylmethylamine and 1-(2-aminoethyl)-piperazine which effectively activated Zn-Cam (K(A)s of 10.1-11.4 microM) and serotonin, L-adrenaline and 2-pyridylmethylamine which were the best Co-Cam activators (K(A)s of 0.97-8.9 microM). We prove here that the activation mechanisms of the alpha-, beta-, and gamma-class CAs are similar, although the activation profiles with various compounds differ dramatically between these diverse enzymes.

Optimized Hyper Beamforming of Linear Antenna Arrays Using Collective Animal Behaviour

PubMed Central

Ram, Gopi; Mandal, Durbadal; Kar, Rajib; Ghoshal, Sakti Prasad

2013-01-01

A novel optimization technique which is developed on mimicking the collective animal behaviour (CAB) is applied for the optimal design of hyper beamforming of linear antenna arrays. Hyper beamforming is based on sum and difference beam patterns of the array, each raised to the power of a hyperbeam exponent parameter. The optimized hyperbeam is achieved by optimization of current excitation weights and uniform interelement spacing. As compared to conventional hyper beamforming of linear antenna array, real coded genetic algorithm (RGA), particle swarm optimization (PSO), and differential evolution (DE) applied to the hyper beam of the same array can achieve reduction in sidelobe level (SLL) and same or less first null beam width (FNBW), keeping the same value of hyperbeam exponent. Again, further reductions of sidelobe level (SLL) and first null beam width (FNBW) have been achieved by the proposed collective animal behaviour (CAB) algorithm. CAB finds near global optimal solution unlike RGA, PSO, and DE in the present problem. The above comparative optimization is illustrated through 10-, 14-, and 20-element linear antenna arrays to establish the optimization efficacy of CAB. PMID:23970843

Final Report on the Audit of Subcontract Prices on Firm-Fixed-Price Contracts Awarded to McDonnell Aircraft Company

DTIC Science & Technology

1990-12-03

This is our final report on the audit of Subcontract Prices on Firm-Fixed-Price Contracts Awarded to McDonnell Aircraft Company (MCAIR). The Contract Management Directorate made the audit from October 1989 through June 1990. The objective of the audit was to compare proposed and negotiated subcontract prices and determine reasons for significant variances. We also evaluated applicable internal control procedures. For a 6-month period ending December 1989, MCAIR issued 517 subcontracts valued at $679 million.

77 FR 18106 - Award Fee for Service and End-Item Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

.... SUMMARY: NASA has adopted, without change, a final rule amending the NASA FAR Supplement (NFS) to update the Award Fee for Service Contracts clause (NFS 1852.216-76) to clarify that the amount of award fee... Award Fee for End-Item Contracts clause (NFS 1852.216-77) to allow the contracting officer to withhold...

Second-line treatment for metastatic clear cell renal cell cancer: experts' consensus algorithms.

PubMed

Rothermundt, C; von Rappard, J; Eisen, T; Escudier, B; Grünwald, V; Larkin, J; McDermott, D; Oldenburg, J; Porta, C; Rini, B; Schmidinger, M; Sternberg, C N; Putora, P M

2017-04-01

Second-line systemic treatment options for metastatic clear cell renal cell cancer (mccRCC) are diverse and treatment strategies are variable among experts. Our aim was to investigate the approach for the second-line treatment after first-line therapy with a tyrosine kinase inhibitor (TKI). Recently two phase III trials have demonstrated a potential role for nivolumab (NIV) and cabozantinib (CAB) in this setting. We aimed to estimate the impact of these trials on clinical decision making. Eleven international experts were asked to provide their treatment strategies for second-line systemic therapy for mccRCC in the current setting and once NIV and CAB will be approved and available. The treatment strategies were analyzed with the objective consensus approach. The analysis of the decision trees revealed everolimus (EVE), axitinib (AXI), NIV and TKI switch (sTKI) as therapeutic options after first-line TKI therapy in the current situation and mostly NIV and CAB in the future setting. The most commonly used criteria for treatment decisions were duration of response, TKI tolerance and zugzwang a composite of several related criteria. In contrast to the first-line setting, recommendations for second-line systemic treatment of mccRCC among experts were not as heterogeneous. The agents mostly used after disease progression on a first-line TKI included: EVE, AXI, NIV and sTKI. In the future setting of NIV and CAB availability, NIV was the most commonly chosen drug, whereas several experts identified situations where CAB would be preferred.

78 FR 48716 - Notice of Availability of the Final Environmental Impact Statement for the Arkansas Valley...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... Reservoir to store up to 29,938 acre-feet of water. A long-term storage contract, rather than short-term... Availability of the Final Environmental Impact Statement for the Arkansas Valley Conduit and Long-Term Excess... Valley Conduit (AVC) and Long-Term Excess Capacity Contract, Fryingpan-Arkansas Project, Colorado, is...

75 FR 18113 - Magnuson-Stevens Act Provisions; Fisheries of the Northeastern United States; Northeast...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... final operations plan, contract, and environmental assessment (EA), and the Final Regulatory Flexibility... fish in a given FY, it must submit an operations plan, sector contract, and EA to NMFS by September 1... National Environmental Policy Act (NEPA), an EA was prepared for each operations plan. All sector EAs are...

Navigational Strategies of Migrating Monarch Butterflies

DTIC Science & Technology

2014-11-10

AFRL-OSR-VA-TR-2014-0339 NAVIGATIONAL STRATEGIES OF MIGRATING MONARCH BUTTERFLIES Steven Reppert UNIVERSITY OF MASSACHUSETTS Final Report 11/10/2014...Final Progress Statement to (Dr. Patrick Bradshaw) Contract/Grant Title: Navigational Strategies of Migrating Monarch Butterflies Contract...Grant #: FA9550-10-1-0480 Reporting Period: 01-Sept-10 to 31-Aug-14 Overview of accomplishments: Migrating monarch butterflies (Danaus

25 CFR 256.20 - How are these repairs or construction trades persons, home building contractors, or construction...

Code of Federal Regulations, 2010 CFR

2010-04-01

... statement of work, which identifies the work to be performed. The appropriate contracting office uses the... completing the project as advertised. (a) Payments to the winning bidder are negotiated in the contract and... the completed work. (2) Final payment will be made after final inspection and after all provisions of...

Weighing the Contract Option.

ERIC Educational Resources Information Center

Dervarics, Charles

1993-01-01

Contracting for noneducational services is standard operating procedure in many school districts. Private contractors are involved in transportation, food service, maintenance, and even, in rare cases, instruction. Before deciding to contract out, school boards should examine improvement to school-run operations before making a final decision.…

Whither Performance Contracting?

ERIC Educational Resources Information Center

Green, Norman S.

This report describes briefly performance contracts; discusses their shortcomings, pitfalls, and advantages; and gives some insight into the future development of this new concept. Two shortcomings of performance contracting include (1) teaching to the test and (2) board abdication of its responsibility for making final decisions about educational…

Determination of the effect of brand and product identification on consumer palatability ratings of ground beef patties.

PubMed

Wilfong, A K; McKillip, K V; Gonzalez, J M; Houser, T A; Unruh, J A; Boyle, E A E; O'Quinn, T G

2016-11-01

The objective of this study was to determine the effect of brand and product identification on consumer palatability ratings of ground beef patties. Six treatments were used in the study: 90/10 Certified Angus Beef (CAB) ground sirloin, 90/10 ground beef, 80/20 CAB ground chuck, 80/20 ground chuck, 80/20 ground beef, and 73/27 CAB ground beef. Ground beef was processed into 151.2-g patties using a patty former with 2 consecutively formed patties assigned to blind consumer testing and the following 2 assigned to informed testing. Following cooking to 74°C, patties were cut into quarters and served to consumers. Consumers ( = 112) evaluated samples in 2 rounds for tenderness, juiciness, flavor liking, texture liking, and overall liking. Each trait was also rated as either acceptable or unacceptable. In the first round of testing, samples were blind evaluated, with no information about the treatments provided to consumers, but in the second round, product type and brand were disclosed prior to sample evaluation. Additionally, texture profile and shear force analyses were performed on patties from each treatment. Few differences were observed for palatability traits during blind consumer testing; however, during informed testing, 90/10 CAB ground sirloin was rated greatest ( < 0.05) for all palatability traits other than juiciness. Also, 90/10 CAB ground sirloin had increased ( < 0.05; (consumer informed score - consumer blind score)/consumer blind score) ratings for tenderness (17.4%), juiciness (36.5%), flavor liking (23.3%), texture liking (18.2%), and overall liking (24.7%) due to brand disclosure. Increased ( < 0.05) ratings were found for CAB products for multiple traits due to treatment disclosure, whereas the only non-CAB-branded product that received increased ( < 0.05) ratings during informed testing was 90/10 ground beef for tenderness and juiciness. Texture results indicated that decreased fat level increased hardness, cohesiveness, gumminess, and chewiness. These results indicate that when sampling ground beef without brand and product information, few consumers find differences in eating quality among ground beef treatments; however, when consumers are aware of the brand, fat level, and subprimal blend prior to sampling, these factors have a large impact on consumer eating satisfaction.

KSC-04PD-1043

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- STS-114 Pilot James Kelly (left) talks with NASA Systems Engineer Robert Rokobauer inside one of the cabs on a Crawler-Transporter. The crawlers had recent modifications to the cab and muffler system. The STS-114 mission is Logistics Flight 1, which is scheduled to deliver supplies and equipment plus the external stowage platform to the International Space Station.

Controlled and high throughput fabrication of poly(trimethylene terephthalate) nanofibers via melt extrusion of immiscible blends

USDA-ARS?s Scientific Manuscript database

Immiscible blends of cellulose acetate butyrate (CAB) and poly(trimethylene terephthalate) (PTT) were melt extruded through a two strand rod die. The extrudates were hot-drawn at the die exit at different draw ratios. PTT fibers were obtained by removal of the CAB matrix from the drawn extrudates, a...

Controlled and high throughput fabrication of poly(trimethylene terphthalate) nanofibers via melt extrusion of immiscible blends

USDA-ARS?s Scientific Manuscript database

Immiscible blends of cellulose acetate butyrate (CAB) and poly(trimethylene terephthalate) (PTT) were melt extruded through a two strand rod die. The extrudates were hot-drawn at the die exit at different draw ratios. PTT fibers were obtained by removal of the CAB matrix from the drawn extrudates, a...

49 CFR 238.405 - Longitudinal static compressive strength.

Code of Federal Regulations, 2012 CFR

2012-10-01

... crash refuge for crewmembers occupying the cab of a power car, the underframe of the cab of a power car... volumes of a power car or a trailer car designed to crush as part of the crash energy management design...) The underframe of the occupied volume of each trailer car shall resist a minimum longitudinal static...

49 CFR 238.405 - Longitudinal static compressive strength.

Code of Federal Regulations, 2014 CFR

2014-10-01

... crash refuge for crewmembers occupying the cab of a power car, the underframe of the cab of a power car... volumes of a power car or a trailer car designed to crush as part of the crash energy management design...) The underframe of the occupied volume of each trailer car shall resist a minimum longitudinal static...

49 CFR 238.405 - Longitudinal static compressive strength.

Code of Federal Regulations, 2013 CFR

2013-10-01

... crash refuge for crewmembers occupying the cab of a power car, the underframe of the cab of a power car... volumes of a power car or a trailer car designed to crush as part of the crash energy management design...) The underframe of the occupied volume of each trailer car shall resist a minimum longitudinal static...

21 CFR 26.68 - Withdrawal of listed conformity assessment bodies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Withdrawal of listed conformity assessment bodies... EUROPEAN COMMUNITY âFrameworkâ Provisions § 26.68 Withdrawal of listed conformity assessment bodies. The... assessment body (CAB): (a) A party proposing to withdraw a CAB listed in subpart B of this part shall forward...

Predictions of the Electronic Structure and Related Properties of Cubic Calcium Hexaboride (CaB6)

DTIC Science & Technology

2010-06-01

not display a currently valid OMB control number. 1. REPORT DATE JUN 2010 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE...TERAKURA, AND T. MIYAKE . 2002. Abnormal Quasiparticle shifts in CaB6. Phys. Rev. B. 66: 121103-1-121103-4. LEE, BYOUNGHAK, AND LIN-WANG WANG. 2005

A New Conception of Bucket Wheel Excavator Cab and Seat Mounting

NASA Astrophysics Data System (ADS)

Blekta, J.; Mevald, J.; Petríková, I.; Petříček, J.; Lufinka, A.

One of the most important problem of coal mining by bucket wheel excavators is how to minimize influence of vibrations on driver's body. Project of Ministry of Trade and Industry of the Czech Republic solved in Technical University of Liberec was engaged in this problem. The aim of this project was to design a new cab and seat mounting of wheel excavator Schrs 1320. A suitable possibilities of cab suspensions were investigated to minimize driver body vibrations and to improve influence of mining process to drivers health. After optimization one concept was chosen. A new methodic of measured data evaluation was created for using in excavators as well as in laboratory. The new concept of dynamic seat absorber were designed also.

77 FR 43780 - Federal Acquisition Regulation; Changes to Time-and-Materials and Labor-Hour Contracts and Orders

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Federal Acquisition Regulation; Changes to Time-and-Materials and Labor-Hour Contracts and Orders AGENCIES... changing the scope of work for a time-and-materials (T&M) or labor-hour (LH) contract or order. DATES...-043, ``Time-and-Materials and Labor-Hour Contracts for Commercial Items'', was published as a final...

Cost and Schedule Analytical Techniques Development: Option 2 Year

NASA Technical Reports Server (NTRS)

1997-01-01

This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) for the Option 2 Year from December 1, 1996 through November 30, 1997. The Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides products and deliverable in the form of models, data bases, methodologies, studies and analyses for the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PPO3) the Program Plans and Requirements Officer (PP02), and other user organizations. Detailed Monthly Progress reports were submitted to MSFC in accordance with the contract's Statement of Work, Section TV "Reporting and Documentation". These reports spelled out each month's specific work accomplishments, deliverables submitted, major meetings held, and other pertinent information. This Final Report will summarize these activities at higher level. During this contract Option Year, SAIC expended 29,830 man-hours in tile performance of tasks called out in the Statement of Work and reported oil in this yearly Final Report. This represents approximately 16 full-time EPs. Included are the basis Huntsville-based team, plus SAIC specialists in San Diego, Ames Research Center, Chicago, and Colorado Springs performing specific tasks for which they are uniquely qualified.

Ethanol production from cashew apple bagasse: improvement of enzymatic hydrolysis by microwave-assisted alkali pretreatment.

PubMed

Rodrigues, Tigressa Helena Soares; Rocha, Maria Valderez Ponte; de Macedo, Gorete Ribeiro; Gonçalves, Luciana R B

2011-07-01

In this work, the potential of microwave-assisted alkali pretreatment in order to improve the rupture of the recalcitrant structures of the cashew able bagasse (CAB), lignocellulosic by-product in Brazil with no commercial value, is obtained from cashew apple process to juice production, was studied. First, biomass composition of CAB was determined, and the percentage of glucan and lignin was 20.54 ± 0.70% and 33.80 ± 1.30%, respectively. CAB content in terms of cellulose, hemicelluloses, and lignin, 19.21 ± 0.35%, 12.05 ± 0.37%, and 38.11 ± 0.08%, respectively, was also determined. Results showed that, after enzymatic hydrolysis, alkali concentration exerted influence on glucose formation, after pretreatment with 0.2 and 1.0 mo L(-1) of NaOH (372 ± 12 and 355 ± 37 mg g(glucan)(-1) ) when 2% (w/v) of cashew apple bagasse pretreated by microwave-assisted alkali pretreatment (CAB-M) was used. On the other hand, pretreatment time (15-30 min) and microwave power (600-900 W) exerted no significant effect on hydrolysis. On enzymatic hydrolysis step, improvement on solid percentage (16% w/v) and enzyme load (30 FPU g (CAB-M) (-1) ) increased glucose concentration to 15 g L(-1). The fermentation of the hydrolyzate by Saccharomyces cerevesiae resulted in ethanol concentration and productivity of 5.6 g L(-1) and 1.41 g L(-1) h(-1), respectively.

Genetic interrelationships among phosphorus, nitrogen, calcium, and energy bioavailability in a growing chicken population.

PubMed

Ankra-Badu, G A; Pesti, G M; Aggrey, S E

2010-11-01

A random-mating population was used to study the genetic interrelationship between phytate P (PPB), Ca (CaB), N (NB), and energy bioavailability (EB), BW at 4 wk of age, relative growth (RG), and feed conversion ratio (FCR). Heritability estimates for PPB, CaB, NB, and EB were 0.09, 0.13, 0.16, and 0.10, respectively, and those of BW, RG, and FCR were 0.66, 0.15, and 0.10, respectively. Genetic correlations between PPB and BW, and FCR were moderate and negative, suggesting that improvement in PPB will impair growth. The genetic correlations between PPB and CaB, and EB and RG were positive and moderate, indicating that improvement in PPB would also lead to improved CaB, EB, and RG. Energy bioavailability was positively correlated with CaB, NB, PPB, and BW. Even though the genetic correlation between EB and the other traits measured, except RG and FCR, ranged from low to moderate, improving the ability of birds to utilize caloric energy in the feed would consequently improve PPB as well as growth. Improving PPB would reduce the amount of P in excreta and provide an additional savings if exogenous phytase were not added to poultry feed. The genetic correlation between PPB and NB was low but positive, whereas NB had a positive genetic correlation with BW. Therefore, selecting on NB will result in positive correlated responses in BW and PPB. Improving PPB and NB will not only improve productivity, but also reduce the polluting effects of P and N on the environment.

Understanding Disproportionate Representation in Special Education by Examining Group Differences in Behavior Ratings

ERIC Educational Resources Information Center

Peters, Christina D.; Kranzler, John H.; Algina, James; Smith, Stephen W.; Daunic, Ann P.

2014-01-01

The aim of the current study was to examine mean-group differences on behavior rating scales and variables that may predict such differences. Sixty-five teachers completed the Clinical Assessment of Behavior-Teacher Form (CAB-T) for a sample of 982 students. Four outcome variables from the CAB-T were assessed. Hierarchical linear modeling was used…

49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of... locomotive, including a cab car and an MU locomotive, shall be: (i) Equivalent to a 1/2-inch steel plate with...

49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of... locomotive, including a cab car and an MU locomotive, shall be: (i) Equivalent to a 1/2-inch steel plate with...

49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of... locomotive, including a cab car and an MU locomotive, shall be: (i) Equivalent to a 1/2-inch steel plate with...

49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of... locomotive, including a cab car and an MU locomotive, shall be: (i) Equivalent to a 1/2-inch steel plate with...

49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of... locomotive, including a cab car and an MU locomotive, shall be: (i) Equivalent to a 1/2-inch steel plate with...

49 CFR Appendix H to Part 229 - Static Noise Test Protocols-In-Cab Static

Code of Federal Regulations, 2010 CFR

2010-10-01

... Federal Railroad Administration, Docket Room, 1200 New Jersey Avenue, SE., Washington, DC 20950, or at the... measured at each of the following locations: (A) 30 inches above the center of the left seat; (B) Centered in the middle of the cab between the right and left seats, and 56 inches above the floor; (C) 30...

The Compensatory ADHD Behaviors Scale (CABS): Development and Initial Validation.

PubMed

Castagna, Peter J; Roye, Scott; Calamia, Matthew

2018-05-01

Several measures are available that assess inattention, hyperactivity/impulsivity, and executive functioning deficits. Treatments for adults with attention-deficit/hyperactivity disorder (ADHD) and skill-based academic interventions focus on improving compensatory strategies to ameliorate functional impairment; however, no measure exists that examines the compensatory behaviors adults utilize to compensate for the functional deficits associated with inattention and hyperactivity/impulsivity. The current study aimed to determine the psychometric properties of the Compensatory ADHD Behaviors Scale (CABS). Five-hundred participants ( M age = 36.83, SD = 11.57) completed measures of ADHD symptomatology, executive functioning, functional impairment, mood disorder symptoms, and the CABS. Analyses revealed that scales assessing both use and effectiveness of compensatory behaviors subscales had similar factor structures, reflecting present- and future-oriented behaviors. The present-, but not future-oriented, behaviors significantly related to ADHD symptomatology, executive dysfunction, and functional impairment; effectiveness of present-oriented compensatory behaviors demonstrated incremental validity in predicting impairment. Compensatory strategies may be a useful variable to measure when examining functional impairment associated with inattention and hyperactivity/impulsivity. The current study provides preliminary evidence of the ability of CABS to validly measure various strategies associated with (clinical and subclinical) ADHD symptomatology, executive functioning, and overall impairment.

CABS: Green Energy for Our Nation's Future (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

"CABS: Green Energy for our Nation's Future" was submitted by the Center for Advanced Biofuel Systems (CABS) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CABS, an EFRC directed by Jan Jaworski at the Donald Danforth Plant Science Center is a partnership of scientists from five institutions: Donald Danforth Plant Science Center (lead), Michigan State University, the University of Nebraska, New Mexico Consortium/LANL, and Washington State University. Themore » Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

[Simulation of vegetation indices optimizing under retrieval of vegetation biochemical parameters based on PROSPECT + SAIL model].

PubMed

Wu, Ling; Liu, Xiang-Nan; Zhou, Bo-Tian; Liu, Chuan-Hao; Li, Lu-Feng

2012-12-01

This study analyzed the sensitivities of three vegetation biochemical parameters [chlorophyll content (Cab), leaf water content (Cw), and leaf area index (LAI)] to the changes of canopy reflectance, with the effects of each parameter on the wavelength regions of canopy reflectance considered, and selected three vegetation indices as the optimization comparison targets of cost function. Then, the Cab, Cw, and LAI were estimated, based on the particle swarm optimization algorithm and PROSPECT + SAIL model. The results showed that retrieval efficiency with vegetation indices as the optimization comparison targets of cost function was better than that with all spectral reflectance. The correlation coefficients (R2) between the measured and estimated values of Cab, Cw, and LAI were 90.8%, 95.7%, and 99.7%, and the root mean square errors of Cab, Cw, and LAI were 4.73 microg x cm(-2), 0.001 g x cm(-2), and 0.08, respectively. It was suggested that to adopt vegetation indices as the optimization comparison targets of cost function could effectively improve the efficiency and precision of the retrieval of biochemical parameters based on PROSPECT + SAIL model.

Conceptual design study for an advanced cab and visual system, volume 1

NASA Technical Reports Server (NTRS)

Rue, R. J.; Cyrus, M. L.; Garnett, T. A.; Nachbor, J. W.; Seery, J. A.; Starr, R. L.

1980-01-01

A conceptual design study was conducted to define requirements for an advanced cab and visual system. The rotorcraft system integration simulator is for engineering studies in the area of mission associated vehicle handling qualities. Principally a technology survey and assessment of existing and proposed simulator visual display systems, image generation systems, modular cab designs, and simulator control station designs were performed and are discussed. State of the art survey data were used to synthesize a set of preliminary visual display system concepts of which five candidate display configurations were selected for further evaluation. Basic display concepts incorporated in these configurations included: real image projection, using either periscopes, fiber optic bundles, or scanned laser optics; and virtual imaging with helmet mounted displays. These display concepts were integrated in the study with a simulator cab concept employing a modular base for aircraft controls, crew seating, and instrumentation (or other) displays. A simple concept to induce vibration in the various modules was developed and is described. Results of evaluations and trade offs related to the candidate system concepts are given, along with a suggested weighting scheme for numerically comparing visual system performance characteristics.

Tannase Production by Solid State Fermentation of Cashew Apple Bagasse

NASA Astrophysics Data System (ADS)

Podrigues, Tigressa H. S.; Dantas, Maria Alcilene A.; Pinto, Gustavo A. S.; Gonçalves, Luciana R. B.

The ability of Aspergillus oryzae for the production of tannase by solid state fermentation was investigated using cashew apple bagasse (CAB) as substrate. The effect of initial water content was studied and maximum enzyme production was obtained when 60 mL of water was added to 100.0 g of CAB. The fungal strain was able to grow on CAB without any supplementation but a low enzyme activity was obtained, 0.576 U/g of dry substrate (gds). Optimization of process parameters such as supplementation with tannic acid, phosphorous, and different organic and inorganic nitrogen sources was studied. The addition of tannic acid affected the enzyme production and maximum tannase activity (2.40 U/gds) was obtained with 2.5% (w/w) supplementation. Supplementation with ammonium nitrate, peptone, and yeast extract exerted no influence on tannase production. Ammonium sulphate improved the enzyme production in 3.75-fold compared with control. Based on the experimental results, CAB is a promising substrate for solid state fermentation, enabling A. oryzae growth and the production of tannase, with a maximum activity of 3.42 U/gds and enzyme productivity of 128.5×10-3 U·gds -1·h-1.

75 FR 22706 - Defense Federal Acquisition Regulation Supplement; Service Contract Surveillance (DFARS Case 2008...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

...DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to ensure that the requirement for a quality assurance surveillance plan is addressed for each contract with a dollar value above the simplified acquisition threshold, and that contracts for services have appropriate performance management or surveillance plans prepared for the work being performed under the contract.

Motor training reduces surround inhibition in the motor cortex.

PubMed

Akkad, Haya; Di Stasio, Flavio; Tibold, Robert; Kassavetis, Panagiotis; Rothwell, John C; Edwards, Mark J

2016-06-01

Surround inhibition (SI) is thought to facilitate focal contraction of a hand muscle by keeping nearby muscles silent. Unexpectedly, SI is reduced in skilled pianists. We tested whether repeated practice of focal contraction in non-pianists could reduce SI. Motor-evoked potentials were elicited by transcranial magnetic stimulation in the relaxed abductor digiti minimi randomly at the onset and 5s after offset of a 2s focal contraction (10% maximum) of the first dorsal interosseous (FDI). Over 5 blocks of 40 trials participants obtained points for increasing contraction speed and stability in FDI. In a final block, the interval between contractions was varied randomly to increase attention to the task. Over the first 5 blocks, SI declined as performance (points scored) improved. In the final "attention" block SI increased towards baseline without affecting performance. Although SI may be useful during the early stages of learning, skilled focal finger movement does not require SI to prevent activity in non-involved muscles. This could be due to better targeting of the excitatory command to move. Results from the final block suggest that increased attention can re-engage SI when task parameters change. SI is not necessary for successful focal contraction, but may contribute during learning and during attention to task. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

77 FR 13508 - Certainty of Terms of Service Contracts and NVOCC Service Arrangements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... in a service contract with a carrier, although their experience with such index- linked contracts is... adjust based upon an index reflecting changes in market conditions. DATES: The Final Rule is effective March 7, 2012. FOR FURTHER INFORMATION CONTACT: Karen V. Gregory, Secretary, Federal Maritime Commission...

39 CFR 601.109 - Contract claims and disputes.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: INTELLECTUAL PROPERTY RIGHTS OTHER THAN PATENTS PURCHASING OF PROPERTY AND SERVICES § 601.109 Contract claims... decision on a claim, and even when the supplier does not agree to use ADR, the contracting officer should... issuance of a final decision. (c) Supplier claim initiation. Supplier claims must be submitted in writing...

23 CFR 635.127 - Agreement provisions regarding overruns in contract time.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.127 Agreement... types. These rates shall, as a minimum, be established to cover the estimated average daily construction... proportional share, as used in this section, is the ratio of the final contract construction costs eligible for...

23 CFR 635.127 - Agreement provisions regarding overruns in contract time.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.127 Agreement... types. These rates shall, as a minimum, be established to cover the estimated average daily construction... proportional share, as used in this section, is the ratio of the final contract construction costs eligible for...

23 CFR 635.127 - Agreement provisions regarding overruns in contract time.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.127 Agreement... types. These rates shall, as a minimum, be established to cover the estimated average daily construction... proportional share, as used in this section, is the ratio of the final contract construction costs eligible for...

23 CFR 635.127 - Agreement provisions regarding overruns in contract time.

Code of Federal Regulations, 2014 CFR

2014-04-01

... ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.127 Agreement... types. These rates shall, as a minimum, be established to cover the estimated average daily construction... proportional share, as used in this section, is the ratio of the final contract construction costs eligible for...

23 CFR 635.127 - Agreement provisions regarding overruns in contract time.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.127 Agreement... types. These rates shall, as a minimum, be established to cover the estimated average daily construction... proportional share, as used in this section, is the ratio of the final contract construction costs eligible for...

Electro-deposition painting process improvement of cab truck by Six Sigma concept

NASA Astrophysics Data System (ADS)

Kawitu, Kitiya; Chutima, Parames

2017-06-01

The case study company is a manufacturer of trucks and currently facing a high rework cost due to the thickness of the electro-deposited paint (EDP) of the truck cab is lower than standard. In addition, the process capability is very low. The Six Sigma concept consisting of 5 phases (DMAIC) is applied to determine new parameter settings for each significant controllable factor. After the improvement, EDP thickness of the truck cab increases from 17.88μ to 20μ (i.e. standard = 20 ± 3μ). Moreover, the process capability indexes (Cp and Cpk) are increased from 0.9 to 1.43, and from 0.27 to 1.43, respectively. This improvement could save the rework cost about 1.6M THB per year.

Tectonic uplift and denudation rate influence soil chemical weathering intensity in a semi-arid environment, southeast Spain: physico-chemical and mineralogical evidence

NASA Astrophysics Data System (ADS)

Ameijeiras-Mariño, Yolanda; Opfergelt, Sophie; Schoonejans, Jérôme; Vanacker, Veerle; Sonnet, Philippe; Delmelle, Pierre

2015-04-01

Tectonic uplift is known to influence denudation rates. Denudation, including chemical weathering and physical erosion, affects soil production rates and weathering intensities. At topographic steady state, weathering can be transport- or weathering-limited. In the transport-limited regime, low denudation rates should lead to comparatively high weathering intensities, while in the weathering-limited case high denudation rates are associated with lower weathering intensities. Here, we test if this relationship applies to semi-arid environments where chemical weathering is generally slow. Three catchments (EST, FIL and CAB) were studied in the Internal Zone of the Betic Cordillera in southeast Spain, spanning a range of increasing uplift rates (10-170 mm/kyr) and increasing denudation rates (20-250 mm/kyr) from EST to CAB. In each catchment, two ridgetop soil profiles were sampled down to the bedrock. The three catchments have similar vegetation and climatic conditions, with precipitation of 250- 315 mm/yr and mean annual temperature of 15-17 °C. The mineralogy of the bedrock, as determined by XRD, is similar across the three catchments and is characterized by the presence of quartz, muscovite, clinochlore, biotite and plagioclase. This primary mineral assemblage is also found in the catchment soils, indicating that the soils studied derive from the same parent material. The soil clay-size fraction is dominated by kaolinite, vermiculite and illite. However, the proportions of the soil primary and secondary minerals vary between the catchment sites. The abundance of biotite decreases from CAB (14%) to EST (4%), whereas the quartz and clay contents show an opposite tendency (from 30 to 69% and 9.9 to 14.3%, respectively). Further, the abundance of vermiculite increases from CAB to EST. The results are interpreted in terms of increasing weathering intensity from CAB to EST by weathering of biotite into vermiculite and enrichment of soils on more weathering resistant quartz. Soil weathering intensity in each catchment was assessed previously [1] using three independent weathering indices: the Total Reserve in Bases (TRB = [Ca2+] + [Na+] + [K+] + [Mg2+]), soil Fed/Fet ratio (Fe-oxides/total Fe), and Cation Exchange Capacity (CEC). In agreement with the soil mineralogy, the physico-chemical analyses revealed increasing weathering intensity from CAB to EST. We postulate that the higher chemical weathering intensity in EST reflects lower denudation and uplift rates compared to CAB and therefore, soil chemical weathering intensity in this semi-arid environment may be controlled by denudation and uplift rates [1] Ameijeiras-Mariño et al, EGU 2014-9714-1

Concomitant Carotid and Coronary Artery Reconstruction

PubMed Central

Craver, Joseph M.; Murphy, Douglas A.; Jones, Ellis L.; Curling, Patrick E.; Bone, David K.; Smith, Robert B.; Perdue, Garland D.; Hatcher, Charles R.; Kandrach, Michael

1982-01-01

Data are presented on 68 patients who underwent concomitant carotid endarterectomy (CE) and coronary artery bypass surgery (CAB) at Emory University Hospital from January 1974 to February 1981. This group is then compared with a randomly selected, matched population without known carotid disease who underwent CAB alone. Asymptomatic bruit was the reason for investigation in 40 patients (59%); another 23 patients (34%) experienced transient cerebral ischemic attacks (TIAs); and five patients (7%) had TIA and prior stroke. Carotid stenoses (>75% luminal narrowing) were demonstrated as follows: isolated left, 24 patients; isolated right, 27 patients; and bilateral lesions, 16 patients. One patient had innominate artery stenosis. Associated total occlusion of one or both vertebral arteries was demonstrated in six patients. Ninety-seven per cent of patients had disabling angina pectoris prior to operation; the angina was unstable in 57%, 15% had congestive heart failure, and 54% had had at least one prior myocardial infarction (MI). Single-vessel coronary disease was present in 12.5% of patients, double in 37.5%, triple in 41.1%, and left main stenosis in 9%; 43% of patients had abnormal ventricular contractility. CE was performed on 67 patients (36 left and 31 right); aortocarotid bypass was performed on one. The CE procedures were performed immediately prior to the sternotomy for CAB under the same anesthesia. CAB consisted of single bypass in eight patients (11.8%); double in 16 patients (23.5%); triple in 22 patients (32.4%); and quadruple or more in 22 patients (32.4%) (mean = 2.9 grafts per patient). There was no hospital mortality. Perioperative MI occurred in 2.0% and stroke with residual deficit in 1.3%. Cumulative survival is 98.5% at two years. Sixty-three patients (92%) reported improvement or elimination of anginal symptoms after operation. Rehospitalization for stroke was necessary in 3.7% patients. Postoperative activity levels are; self-care only, 3.9%; normal daily activity only, 17.6%; moderate exercise capability, 45%; and vigorous exercise capability, 33%. Comparison was made with a group of 84 randomly selected patients who underwent CAB alone during the same time interval. Data revealed no significant difference between the groups regarding sex, angina subset, ventricular function, coronary anatomy, vessels grafted, perioperative stroke or MI, mortality, or postoperative activity capability. Older age (59.8 vs. 55.6, p < 0.01) and less complete coronary revascularization possible (66 vs. 84%, p < 0.05) in the CECAB group were the only significant differences. Carotid stenosis co-existing in patients requiring CAB should be concomitantly corrected with the same risk and results expected from CAB alone. PMID:7082063

Multiphase materials with lignin. VI. Effect of cellulose derivative structure on blend morphology with lignin

Treesearch

Timothy G. Rials; Wolfgang G. Glasser

1989-01-01

Polymeric blends of lignin with ethyl cellulose (EC) and cellulose acetate/butyrate (CAB) prepared by solution casting from dioxane. Fracture surface analysis by scanning electron microscopy revealed phase separation when the lignin content exceeded 10% for blends with EC and 5% in the CAB system. While this phase behavior is as predicted for the EC blends, a greater...

Structure Inference from Mobility Encounters

DTIC Science & Technology

2013-10-20

world dataset, which contains 230K trajectories of taxi cabs in Beijing . Our algorithm extracts a pathlet dictionary containing around 130K...data set, frequently used pathlets in the dictionary represent driving segments chosen by many taxi cab drivers in Beijing , reflecting the joint wisdom...limitations on storage and communication bandwidth. For instance, 50% of the Beijing Taxi Trajectories we employed in this study have at most one

Emission estimates of HCFCs and HFCs in California from the 2010 CalNex study

NASA Astrophysics Data System (ADS)

Barletta, Barbara; Carreras-Sospedra, Marc; Cohan, Alex; Nissenson, Paul; Dabdub, Donald; Meinardi, Simone; Atlas, Elliot; Lueb, Rich; Holloway, John S.; Ryerson, Thomas B.; Pederson, James; VanCuren, Richard A.; Blake, Donald R.

2013-02-01

The CalNex 2010 (California Research at the Nexus of Air Quality and Climate Change) study was designed to evaluate the chemical composition of air masses over key source regions in California. During May to June 2010, air samples were collected on board a National Oceanic and Atmospheric Administration (NOAA) WP-3D aircraft over the South Coast Air Basin of California (SoCAB) and the Central Valley (CV). This paper analyzes six effective greenhouse gases—chlorodifluoromethane (HCFC-22), 1,1-dichloro-1-fluoroethane (HCFC-141b), 1-chloro-1,1-difluoroethane (HCFC-142b), 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124), 1,1,1,2-tetrafluoroethane (HFC-134a), and 1,1-difluoroethane (HFC-152a)—providing the most comprehensive characterization of chlorofluorocarbon (CFC) replacement compound emissions in California. Concentrations of measured HCFCs and HFCs are enhanced greatly throughout the SoCAB and CV, with highest levels observed in the SoCAB: 310 ± 92 pptv for HCFC-22, 30.7 ± 18.6 pptv for HCFC-141b, 22.9 ± 2.0 pptv for HCFC-142b, 4.86 ± 2.56 pptv for HCFC-124, 109 ± 46.4 pptv for HFC-134a, and 91.2 ± 63.9 pptv for HFC-152a. Annual emission rates are estimated for all six compounds in the SoCAB using the measured halocarbon to carbon monoxide (CO) mixing ratios and CO emissions inventories. Emission rates of 3.05 ± 0.70 Gg for HCFC-22, 0.27 ± 0.07 Gg for HCFC-141b, 0.06 ± 0.01 Gg for HCFC-142b, 0.11 ± 0.03 Gg for HCFC-124, 1.89 ± 0.43 Gg for HFC-134a, and 1.94 ± 0.45 Gg for HFC-152b for the year 2010 are calculated for the SoCAB. These emissions are extrapolated from the SoCAB region to the state of California using population data. Results from this study provide a baseline emission rate that will help future studies determine if HCFC and HFC mitigation strategies are successful.

Organohalogen contaminants and metabolites in beluga whale (Delphinapterus leucas) liver from two Canadian populations.

PubMed

McKinney, Melissa A; De Guise, Sylvain; Martineau, Daniel; Béland, Pierre; Lebeuf, Michel; Letcher, Robert J

2006-05-01

Contaminants described as organochlorines (OCs; e.g., polychlorinated biphenyls [PCBs]) are present in tissues of marine mammals, including beluga whales (Delphinapterus leucas), but the complexity of contaminant exposure often is not fully known. The PCBs, OC pesticides, polybrominated diphenyl ether (PBDE) flame retardants, methylsulfonyl (MeSO2)- and hydroxy (OH)-PCB metabolites, and OH-PBDEs and methoxylated (MeO)-PBDEs were determined in the liver of beluga whales from two Canadian populations: the St. Lawrence Estuary (SLB; n=6), and western Hudson Bay in the Canadian Arctic (CAB; n=11). The sigmaPCB, sigmaDDT, and sigmaPBDE concentrations were higher (p < 0.05) in SLB versus CAB. Of 18 detectable OH-PCBs in SLB (mainly 4-OH-CB107, 4-OH-CB112, and 4'-OH-CB120), only 4'-OH-CB120 was found in CAB. The sigmaOH-PCB concentrations were less than 0.2% of the sigmaPCBs in both populations but were higher (p < 0.05) in SLB (65 +/- 22 ng/g lipid wt) than in CAB (3.1 +/- 0.5 ng/g lipid wt). The sigmaMeSO2-PCB concentrations were higher in SLB (3801 +/- 1322 ng/g lipid wt) relative to CAB (77 +/- 23 ng/g lipid wt) and were 11 and 4%, respectively, of the sigmaPCB concentrations. Of the 15 OH-PBDEs, only two congeners were detectable, but not quantifiable (notably 2'-OH-BDE 68 and 6-OH-BDE 47), in animals from both populations. Of the 15 MeO-PBDEs, 4'-MeO-BDE 17 and 6-MeO-BDE 47 in the SLB (n=2) and 2'-MeO-BDE 68 and 6-MeO-BDE 47 in the CAB (n=2) had concentrations from 20 to 100 ng/g lipid weight. The OH-PBDEs and MeO-PBDEs most likely are of natural origin and accumulated in beluga whales, whereas the OH-PCBs and MeSO2-PCBs are metabolites derived from accumulated PCBs. Canadian beluga whale liver contains previously unidentified organohalogen contaminants and metabolites and, thus, a complexity of contaminant exposure that may be impacting the health of Canadian beluga whale populations.

48 CFR 52.212-4 - Contract Terms and Conditions-Commercial Items.

Code of Federal Regulations, 2010 CFR

2010-10-01

... issue a demand for payment to the Contractor upon finding a debt is due under the contract. (iii) Final... days; (B) The Contractor fails to liquidate a debt previously demanded by the Contracting Officer within the timeline specified in the demand for payment unless the amounts were not repaid because the...

77 FR 72738 - Contracts and Provider Agreements for State Home Nursing Home Care

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-06

... State Home Nursing Home Care AGENCY: Department of Veterans Affairs. ACTION: Interim final rule. SUMMARY... into contracts or provider agreements with State homes for the nursing home care of certain disabled... submitted in response to ``RIN 2900-AO57--Contracts and Provider Agreements for State Home Nursing Home Care...

Commercial Contract Training, Marine Corps Area VOTEC Support Center (AVSC) Guidelines. Final Report.

ERIC Educational Resources Information Center

Copeland, D. R.; And Others

The report provides a description of the Phase II findings of a two-phase study to determine if certain Marine Corps skill training requirements could be satisfied through contract with qualified commercial sources. It demonstrates the utility of the commercial contract training concept and contains information useful to Area VOTEC…

Alternative contracting research : final report.

DOT National Transportation Integrated Search

2016-08-01

Alternative contracting methods have become popular alternatives to the traditional practice whose emphasis is on low bid acquisition. The benefits of decreased project schedule, increased job quality, and improved delivery process have demonstrated ...

Evaluation of Subcontract Price Proposals

DTIC Science & Technology

1990-04-09

This is the final report on the Audit of the Evaluation of Subcontract Price Proposals. Comments on a draft of this report were considered in...preparing the final report. We made the audit from October 1987 through May 198% The initial objectives of the audit were to evaluate procedures used by...assist audit reports were used by procurement contracting officers in negotiating contract prices. During the audit , we expanded our objectives to

Medicare program; revisions to the Medicare Advantage and Part D prescription drug contract determinations, appeals, and intermediate sanctions processes. Final rule with comment period.

PubMed

2007-12-05

This rule with comment period finalizes the Medicare program provisions relating to contract determinations involving Medicare Advantage (MA) organizations and Medicare Part D prescription drug plan sponsors, including eliminating the reconsideration process for review of contract determinations, revising the provisions related to appeals of contract determinations, and clarifying the process for MA organizations and Part D plan sponsors to complete corrective action plans. In this final rule with comment period, we also clarify the intermediate sanction and civil money penalty (CMP) provisions that apply to MA organizations and Medicare Part D prescription drug plan sponsors, modify elements of their compliance plans, retain voluntary self-reporting for Part D sponsors and implement a voluntary self-reporting recommendation for MA organizations, and revise provisions to ensure HHS has access to the books and records of MA organizations and Part D plan sponsors' first tier, downstream, and related entities. Although we have decided not to finalize the mandatory self-reporting provisions that we proposed, CMS remains committed to adopting a mandatory self-reporting requirement. To that end, we are requesting comments that will assist CMS in crafting a future proposed regulation for a mandatory self-reporting requirement.

Medicaid Integrity Program; eligible entity and contracting requirements for the Medicaid Integrity audit program. Final rule.

PubMed

2008-09-26

Section 1936 of the Social Security Act (the Act) (as added by section 6034 of the Deficit Reduction Act of 2005 (DRA) established the Medicaid Integrity Program to promote the integrity of the Medicaid program by requiring CMS to enter into contracts with eligible entities to: (1) Review the actions of individuals or entities furnishing items or services (whether on a fee-for-service, risk, or other basis) for which payment may be made under an approved State plan and/or any waiver of such plan approved under section 1115 of the Act; (2) audit claims for payment of items or services furnished, or administrative services rendered, under a State plan; (3) identify overpayments to individuals or entities receiving Federal funds; and (4) educate providers of services, managed care entities, beneficiaries, and other individuals with respect to payment integrity and quality of care. This final rule will provide requirements for an eligible entity to enter into a contract under the Medicaid integrity audit program. The final rule will also establish the contracting requirements for eligible entities. The requirements will include procedures for identifying, evaluating, and resolving organizational conflicts of interest that are generally applicable to Federal acquisition and procurement; competitive procedures to be used; and procedures under which a contract may be renewed.

Sleeper Cab Climate Control Load Reduction for Long-Haul Truck Rest Period Idling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lustbader, J. A.; Kreutzer, C.; Adelman, S.

2015-04-29

Annual fuel use for long-haul truck rest period idling is estimated at 667 million gallons in the United States. The U.S. Department of Energy’s National Renewable Energy Laboratory’s CoolCab project aims to reduce heating, ventilating, and air conditioning (HVAC) loads and resulting fuel use from rest period idling by working closely with industry to design efficient long-haul truck climate control systems while maintaining occupant comfort. Enhancing the thermal performance of cab/sleepers will enable smaller, lighter, and more cost-effective idle reduction solutions. In order for candidate idle reduction technologies to be implemented at the original equipment manufacturer and fleet level, theirmore » effectiveness must be quantified. To address this need, a number of promising candidate technologies were evaluated through experimentation and modeling to determine their effectiveness in reducing rest period HVAC loads. For this study, load reduction strategies were grouped into the focus areas of solar envelope, occupant environment, and conductive pathways. The technologies selected for a complete-cab package of technologies were “ultra-white” paint, advanced insulation, and advanced curtains. To measure the impact of these technologies, a nationally-averaged solar-weighted reflectivity long-haul truck paint color was determined and applied to the baseline test vehicle. Using the complete-cab package of technologies, electrical energy consumption for long-haul truck daytime rest period air conditioning was reduced by at least 35% for summer weather conditions in Colorado. The National Renewable Energy Laboratory's CoolCalc model was then used to extrapolate the performance of the thermal load reduction technologies nationally for 161 major U.S. cities using typical weather conditions for each location over an entire year.« less

HFC-152a and HFC-134a emission estimates and characterization of CFCs, CFC replacements, and other halogenated solvents measured during the 2008 ARCTAS campaign (CARB phase) over the South Coast Air Basin of California

NASA Astrophysics Data System (ADS)

Barletta, B.; Nissenson, P.; Meinardi, S.; Dabdub, D.; Sherwood Rowland, F.; Vancuren, R. A.; Pederson, J.; Diskin, G. S.; Blake, D. R.

2011-03-01

This work presents results from the NASA Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) study. Whole air samples were obtained on board research flights that flew over California during June 2008 and analyzed for selected volatile organic compounds, including several halogenated species. Samples collected over the South Coast Air Basin of California (SoCAB), which includes much of Los Angeles (LA) County, were compared with samples from inflow air masses over the Pacific Ocean. The levels of many halocarbon species were enhanced significantly over the SoCAB, including compounds regulated by the Montreal Protocol and subsequent amendments. Emissions estimates of HFC-152a (1,1-difluoroethane, CH3CHF2; 0.82 ± 0.11 Gg) and HFC-134a (1,1,1,2-tetrafluoroethane, CH2FCF3; 1.16 ± 0.22 Gg) in LA County for 2008 were obtained using the observed HFC:carbon monoxide (CO) enhancement ratio. Emission rates also were calculated for the SoCAB (1.60 ± 0.22 Gg yr-1 for HFC-152a and 2.12 ± 0.28 Gg yr-1 for HFC-134a) and then extrapolated to the United States (32 ± 4 Gg yr-1 for HFC-152a and 43 ± 6 Gg yr-1 for HFC-134a) using population data. In addition, emission rates of the two HFCs in LA County and SoCAB were calculated by a second method that utilizes air quality modeling. Emissions estimates obtained using both methods differ by less than 25% for the LA County and less than 45% for the SoCAB.

Rapid and sensitive sandwich enzyme-linked immunosorbent assay for detection of staphylococcal enterotoxin B in cheese.

PubMed Central

Morissette, C; Goulet, J; Lamoureux, G

1991-01-01

A rapid and sensitive screening sandwich enzyme-linked immunosorbent assay (ELISA) was developed for the detection of staphylococcal enterotoxin B (SEB) in cheese by using a highly avid anti-SEB antibody (Ab) as the capture Ab (CAb) and as the biotinylated Ab conjugate. The glutaraldehyde fixation method for the immobilization of CAb on polystyrene dipsticks was superior to the adsorption fixation and the adsorption-glutaraldehyde fixation methods. The glutaraldehyde fixation method resulted in a higher surface-saturating CAb concentration as evaluated by the peroxidase saturation technique and by the ability of the CAb-coated dipstick to discriminate between positive and negative controls (index of discrimination). Of nine blocking agents used alone or in pairs, lysine-human serum albumin, bovine serum albumin, human serum albumin, and gelatin effectively saturated available sites on the CAb-coated dipsticks without causing interference with the antigen-Ab reactions. The addition of 1% polyethylene glycol to the diluent of the biotinylated anti-SEB Ab conjugate improved the detection of SEB. A concentration of 4% polyethylene glycol allowed a 5-min reaction time for the streptavidin-biotin-horseradish peroxidase conjugate. Cheddar cheese homogenate reduced the sensitivity of the SEB assay; however, the sensitivity was restored when 1.6% (wt/vol) of either a nonionic detergent (Mega-9) or two zwitterionic detergents (Zwittergent 3-10 and 3-12 detergent) was added to the diluent. By using the rapid sandwich ELISA, a minimum of 0.5 to 1.0 ng of SEB per ml was detected within 45 min. The whole procedure for the analysis of the cheddar cheese samples was completed within 1 h.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2039234

48 CFR 243.204-70-6 - Allowable profit.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-6 Allowable profit. When the final price of an unpriced change order is negotiated after a substantial portion...

48 CFR 243.204-70-6 - Allowable profit.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-6 Allowable profit. When the final price of an unpriced change order is negotiated after a substantial portion...

10 CFR 950.37 - Final agreement or final decision.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Final agreement or final decision. 950.37 Section 950.37 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Dispute Resolution Process § 950.37 Final agreement or final decision. (a) If the parties reach a Final Agreement on a contract...

Driving to Better Health: Cancer and Cardiovascular Risk Assessment among Taxi Cab Operators in Chicago

PubMed Central

Apantaku-Onayemi, Funmi; Baldyga, William; Amuwo, Shaffdeen; Adefuye, Adedeji; Mason, Terry; Mitchell, Robin; Blumenthal, Daniel S.

2014-01-01

While a number of investigations of the health of taxi cab drivers have been conducted in Europe, Asia, and Africa, virtually none have been conducted in the United States. We undertook a survey of taxi cab operators in the Chicago area to understand better their health status and health promotion practices. The survey was completed by a convenience sample of 751 Chicago taxi drivers. Taxi drivers had low rates of insurance coverage, fruit and vegetable consumption, and physical activity compared with the general Chicago population. Participation in cancer screening tests was also lower for this group. A high proportion of taxi drivers are immigrants. They tend to be highly educated and report a readiness to engage in more health-promoting behaviors. Further research is needed to develop a targeted intervention for this population. PMID:22643623

48 CFR 46.707 - Pricing aspects of fixed-price incentive contract warranties.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 46.707 Pricing aspects of... the total final price. Contractor compliance with the warranty after the establishment of the total...

48 CFR 46.707 - Pricing aspects of fixed-price incentive contract warranties.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 46.707 Pricing aspects of... the total final price. Contractor compliance with the warranty after the establishment of the total...

48 CFR 1816.405-271 - Base fee.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... For other contracts, such as those for hardware or software development, the procurement officer may... during the life of the contract at defined intervals on a provisional basis. If the final award fee...

48 CFR 1816.405-271 - Base fee.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... For other contracts, such as those for hardware or software development, the procurement officer may... during the life of the contract at defined intervals on a provisional basis. If the final award fee...

48 CFR 1816.405-271 - Base fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... For other contracts, such as those for hardware or software development, the procurement officer may... during the life of the contract at defined intervals on a provisional basis. If the final award fee...

48 CFR 1816.405-271 - Base fee.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... For other contracts, such as those for hardware or software development, the procurement officer may... during the life of the contract at defined intervals on a provisional basis. If the final award fee...

48 CFR 1816.405-271 - Base fee.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... For other contracts, such as those for hardware or software development, the procurement officer may... during the life of the contract at defined intervals on a provisional basis. If the final award fee...

10 CFR 950.36 - Other contract matters in dispute.

Code of Federal Regulations, 2011 CFR

2011-01-01

... contract matter in dispute. (2) If the parties cannot reach a resolution of the matter in disagreement... the parties reach agreement through mediation, the agreement shall constitute a Final Agreement on the...

48 CFR 1842.7201 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Management Reports, the NASA form 533 series, is required on cost-type, price redetermination, and fixed... implemented in the contract based on the estimated final contract value at the time of award. [62 FR 14017...

Department of Defense’s Waiver of Competitive Prototyping Requirement for Enhanced Polar System Program

DTIC Science & Technology

2012-08-23

objectives. Finally, the CAPS acquisition strategy anticipates the use of a cost- reimbursement contract for designing and building the system...The CAPS acquisition strategy anticipates the use of a cost- reimbursement contract for designing and building the system; however, it may be... reimbursement contract was chosen for the basic CAPS contract because of the nature of the design work, which includes software design and development

Elucidating the Role of cAb1 and the Abi-Family of cAB1 Target Proteins in Cancer Development and Progression

DTIC Science & Technology

2000-07-01

1996;87:2252. members. J Biol Chem. 1996;271:31,704. SH2 regulatory domain in a non-phosphotyro- 36. DiNoto R, LoRardo C, Schiavone EM, et al. Stem 11...Information Center (DTIC-OCA), 8725 John J. Kingman Road, Fort Belvoir, VA 22060-6218 SUBJECT: Request Change in Distribution Statement 1. The U.S. Army

Thermal Comfort Testing for Vehicle Operator/Passenger Workspaces (Truck Cabs)

DTIC Science & Technology

2007-10-09

This TOP describes the procedure to quantify the thermal comfort of a truck cab in temperatures as hot and humid as possible. Facilities, instrumentation, health and safety, test conditions, test procedures, data required, and presentation of data will be discussed in this TOP. This TOP will supplement the following TOPs: TOP 1-1-006, TOP 2-2-508, TOP 2-4-001, and TOP 10-1-003.

PBF Reactor Building (PER620). Camera is in cab of electricpowered ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PBF Reactor Building (PER-620). Camera is in cab of electric-powered rail crane and facing east. Reactor pit and storage canal have been shaped. Floors for wings on east and west side are above and below reactor in view. Photographer: Larry Page. Date: August 23, 1967. INEEL negative no. 67-4403 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

Human Factors Engineering Guidelines for Overhead Cranes

NASA Technical Reports Server (NTRS)

Chandler, Faith; Delgado, H. (Technical Monitor)

2001-01-01

This guideline provides standards for overhead crane cabs that can be applied to the design and modification of crane cabs to reduce the potential for human error due to design. This guideline serves as an aid during the development of a specification for purchases of cranes or for an engineering support request for crane design modification. It aids human factors engineers in evaluating existing cranes during accident investigations or safety reviews.

Can the democratic ideal of participatory research be achieved? An inside look at an academic-indigenous community partnership.

PubMed

Cargo, Margaret; Delormier, Treena; Lévesque, Lucie; Horn-Miller, Kahente; McComber, Alex; Macaulay, Ann C

2008-10-01

Democratic or equal participation in decision making is an ideal that community and academic stakeholders engaged in participatory research strive to achieve. This ideal, however, may compete with indigenous peoples' right to self-determination. Study objectives were to assess the perceived influence of multiple community (indigenous) and academic stakeholders engaged in the Kahnawake Schools Diabetes Prevention Project (KSDPP) across six domains of project decision making and to test the hypothesis that KSDPP would be directed by community stakeholders. Self-report surveys were completed by 51 stakeholders comprising the KSDPP Community Advisory Board (CAB), KSDPP staff, academic researchers and supervisory board members. KSDPP staff were perceived to share similar levels of influence with (i) CAB on maintaining partnership ethics and CAB activities and (ii) academic researchers on research and dissemination activities. KSDPP staff were perceived to carry significantly more influence than other stakeholders on decisions related to annual activities, program operations and intervention activities. CAB and staff were the perceived owners of KSDPP. The strong community leadership aligns KSDPP with a model of community-directed research and suggests that equitable participation-distinct from democratic or equal participation-is reflected by indigenous community partners exerting greater influence than academic partners in decision making.

Rapid electron exchange between surface-exposed bacterial cytochromes and Fe(III) minerals

PubMed Central

White, Gaye F.; Shi, Zhi; Shi, Liang; Wang, Zheming; Dohnalkova, Alice C.; Marshall, Matthew J.; Fredrickson, James K.; Zachara, John M.; Butt, Julea N.; Richardson, David J.; Clarke, Thomas A.

2013-01-01

The mineral-respiring bacterium Shewanella oneidensis uses a protein complex, MtrCAB, composed of two decaheme cytochromes, MtrC and MtrA, brought together inside a transmembrane porin, MtrB, to transport electrons across the outer membrane to a variety of mineral-based electron acceptors. A proteoliposome system containing a pool of internalized electron carriers was used to investigate how the topology of the MtrCAB complex relates to its ability to transport electrons across a lipid bilayer to externally located Fe(III) oxides. With MtrA facing the interior and MtrC exposed on the outer surface of the phospholipid bilayer, the established in vivo orientation, electron transfer from the interior electron carrier pool through MtrCAB to solid-phase Fe(III) oxides was demonstrated. The rates were 103 times higher than those reported for reduction of goethite, hematite, and lepidocrocite by S. oneidensis, and the order of the reaction rates was consistent with those observed in S. oneidensis cultures. In contrast, established rates for single turnover reactions between purified MtrC and Fe(III) oxides were 103 times lower. By providing a continuous flow of electrons, the proteoliposome experiments demonstrate that conduction through MtrCAB directly to Fe(III) oxides is sufficient to support in vivo, anaerobic, solid-phase iron respiration. PMID:23538304

Quantifying the Loss of Processed Natural Gas Within California's South Coast Air Basin Using Long-term Measurements of Ethane and Methane

NASA Astrophysics Data System (ADS)

Wunch, D.; Toon, G. C.; Hedelius, J.; Vizenor, N.; Roehl, C. M.; Saad, K.; Blavier, J. F.; Blake, D. R.; Wennberg, P. O.

2016-12-01

In California's South Coast Air Basin (SoCAB), the methane emissions inferred from atmospheric measurements exceed estimates based on inventories. We seek to provide insight into the sources of the discrepancy with two records of atmospheric trace gas total column abundances in the SoCAB: one temporally sparse dataset that began in the late 1980s, and a temporally dense dataset that began in 2012. We use their measurements of ethane and methane to partition the sources of the excess methane. The early few years of the sparse record show a rapid decline in ethane emissions at a much faster rate than decreasing vehicle exhaust or natural gas and crude oil production can explain. Between 2010 and 2015, ethane emissions have grown gradually, which is in contrast to the steady production of natural gas liquids over that time. Since 2012, ethane to methane ratios in the natural gas withdrawn from a storage facility within the SoCAB have been increasing; these ratios are tracked in our atmospheric measurements with about half of the rate of increase. From this, we infer that about half of the excess methane in the SoCAB between 2012-­2015 is attributable to losses from the natural gas infrastructure.

Pleural tissue hyaluronan produced by postmortem ventilation in rabbits.

PubMed

Wang, P M; Lai-Fook, S J

2000-01-01

We developed a method that used Alcian blue bound to hyaluronan to measure pleural hyaluronan in rabbits postmortem. Rabbits were killed, then ventilated with 21% O2--5% CO2--74% N2 for 3 h. The pleural liquid was removed by suction and 5 ml Alcian blue stock solution (0.33 mg/ml, 3.3 pH) was injected into each chest cavity. After 10 min, the Alcian blue solution was removed and the unbound Alcian blue solution (supernatant) separated by centrifugation and filtration. The supernatant transmissibility (T) was measured spectrophotometrically at 613 nm. Supernatant Alcian blue concentration (Cab) was obtained from a calibration curve of T versus dilutions of stock solution Cab. Alcian blue bound to pleural tissue hyaluronan was obtained by subtracting supernatant Cab from stock solution Cab. Pleural tissue hyaluronan was obtained from a calibration curve of hyaluronan versus Alcian blue bound to hyaluronan. Compared with control rabbits, pleural tissue hyaluronan (0.21 +/- 0.04 mg/kg) increased twofold, whereas pleural liquid volume decreased by 30% after 3 h of ventilation. Pleural effusions present 3 h postmortem without ventilation did not change pleural tissue hyaluronan from control values. Thus ventilation-induced pleural liquid shear stress, not increased filtration, was the stimulus for the increased hyaluronan produced from pleural mesothelial cells.

Consistent View of Protein Fluctuations from All-Atom Molecular Dynamics and Coarse-Grained Dynamics with Knowledge-Based Force-Field.

PubMed

Jamroz, Michal; Orozco, Modesto; Kolinski, Andrzej; Kmiecik, Sebastian

2013-01-08

It is widely recognized that atomistic Molecular Dynamics (MD), a classical simulation method, captures the essential physics of protein dynamics. That idea is supported by a theoretical study showing that various MD force-fields provide a consensus picture of protein fluctuations in aqueous solution [Rueda, M. et al. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 796-801]. However, atomistic MD cannot be applied to most biologically relevant processes due to its limitation to relatively short time scales. Much longer time scales can be accessed by properly designed coarse-grained models. We demonstrate that the aforementioned consensus view of protein dynamics from short (nanosecond) time scale MD simulations is fairly consistent with the dynamics of the coarse-grained protein model - the CABS model. The CABS model employs stochastic dynamics (a Monte Carlo method) and a knowledge-based force-field, which is not biased toward the native structure of a simulated protein. Since CABS-based dynamics allows for the simulation of entire folding (or multiple folding events) in a single run, integration of the CABS approach with all-atom MD promises a convenient (and computationally feasible) means for the long-time multiscale molecular modeling of protein systems with atomistic resolution.

The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code

PubMed Central

Fischer, Frédéric; Huot, Jonathan L.; Lorber, Bernard; Diss, Guillaume; Hendrickson, Tamara L.; Becker, Hubert D.; Lapointe, Jacques; Kern, Daniel

2012-01-01

Helicobacter pylori catalyzes Asn-tRNAAsn formation by use of the indirect pathway that involves charging of Asp onto tRNAAsn by a non-discriminating aspartyl-tRNA synthetase (ND-AspRS), followed by conversion of the mischarged Asp into Asn by the GatCAB amidotransferase. We show that the partners of asparaginylation assemble into a dynamic Asn-transamidosome, which uses a different strategy than the Gln-transamidosome to prevent the release of the mischarged aminoacyl-tRNA intermediate. The complex is described by gel-filtration, dynamic light scattering and kinetic measurements. Two strategies for asparaginylation are shown: (i) tRNAAsn binds GatCAB first, allowing aminoacylation and immediate transamidation once ND-AspRS joins the complex; (ii) tRNAAsn is bound by ND-AspRS which releases the Asp-tRNAAsn product much slower than the cognate Asp-tRNAAsp; this kinetic peculiarity allows GatCAB to bind and transamidate Asp-tRNAAsn before its release by the ND-AspRS. These results are discussed in the context of the interrelation between the Asn and Gln-transamidosomes which use the same GatCAB in H. pylori, and shed light on a kinetic mechanism that ensures faithful codon reassignment for Asn. PMID:22362756

The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code.

PubMed

Fischer, Frédéric; Huot, Jonathan L; Lorber, Bernard; Diss, Guillaume; Hendrickson, Tamara L; Becker, Hubert D; Lapointe, Jacques; Kern, Daniel

2012-06-01

Helicobacter pylori catalyzes Asn-tRNA(Asn) formation by use of the indirect pathway that involves charging of Asp onto tRNA(Asn) by a non-discriminating aspartyl-tRNA synthetase (ND-AspRS), followed by conversion of the mischarged Asp into Asn by the GatCAB amidotransferase. We show that the partners of asparaginylation assemble into a dynamic Asn-transamidosome, which uses a different strategy than the Gln-transamidosome to prevent the release of the mischarged aminoacyl-tRNA intermediate. The complex is described by gel-filtration, dynamic light scattering and kinetic measurements. Two strategies for asparaginylation are shown: (i) tRNA(Asn) binds GatCAB first, allowing aminoacylation and immediate transamidation once ND-AspRS joins the complex; (ii) tRNA(Asn) is bound by ND-AspRS which releases the Asp-tRNA(Asn) product much slower than the cognate Asp-tRNA(Asp); this kinetic peculiarity allows GatCAB to bind and transamidate Asp-tRNA(Asn) before its release by the ND-AspRS. These results are discussed in the context of the interrelation between the Asn and Gln-transamidosomes which use the same GatCAB in H. pylori, and shed light on a kinetic mechanism that ensures faithful codon reassignment for Asn.

The New Jersey Department of Higher Education's Health Manpower Planning Contract. Final Comprehensive Report.

ERIC Educational Resources Information Center

Tomson, Jon; Vasilenko, Patricia

This report of the New Jersey Department of Higher Education's Health Manpower Planning Contract describes project activities and assessment methods and models, presents data on employment supply and demand, and provides samples of questionnaires and forms that were used. The department was required under contract to: survey and evaluate pertinent…

Maintenance and Drainage Guidance for the Scott Base Transition, Antarctica

DTIC Science & Technology

2014-10-01

Way Centennial , CO 80112-3938 Final Report Approved for public release; distribution is unlimited. Prepared for National Science Foundation...References Antarctic Support Contract (ASC). 2014. Scott Base Transition Construction and Maintenance Manual. IO-MAN-0003. Centennial , CO: Antarctic...Support Contract. Antarctic Support Contract (ASC). Forthcoming. Snow Road Construction and Maintenance Manual. IO-MAN-xx. Centennial , CO: Antarctic

Traffic Aware Strategic Aircrew Requests (TASAR) Analysis and Development

NASA Technical Reports Server (NTRS)

Woods, Sharon E.

2016-01-01

This document is the final report and deliverable 30 of Contract No. NNL12AA06C, the Traffic Aware Strategic Aircrew Requests (TASAR) contract awarded via the NASA Research Announcement (NRA). It documents the accomplishments of the contract, the evolution of its role in the overall TASAR project, and lessons learned from its execution.

Titan 4 TPS Replacement Implementation Study

NASA Technical Reports Server (NTRS)

Jackson, Charles H.

1996-01-01

This final report documents the overall progress of the study. It is a general discussion of the documents reviewed, recommendations, trips taken, findings/observations, and proposed corrective actions. In addition, cost data for the contract is addressed. The normal abstract and executive summary provided with most final reports is also provided as a part of this report. A conclusion section is provided that addresses the relative completeness of the Titan 4 TPSR project and this contract.

Final Technical Report for contract number DE-FG02-05ER15670

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glazebrook, Jane

This is the final technical report for contract number DE-FG02-05ER15670. The project is now complete, and results of the project have been published. Two papers were published based on work done in the last three-year funding period. The DOIs of these papers are included below. The abstracts of the papers, providing summaries of the work, are included in the body of the report.

Professional services contract manager development and certification strategy : spr 696 : final report.

DOT National Transportation Integrated Search

2013-02-27

SCDOT hires many consultants to provide professional services in support of its planning, design, construction and : maintenance projects. SCDOT personnel responsible for procuring and administering these professional service : contracts, especially ...

Molecular Dynamics Simulation of Calbindin D9k in Apo, Singly and Doubly Loaded States in Various Side-Chains

NASA Astrophysics Data System (ADS)

Thapa, Mahendra Bahadur

Calbindin D9k (CAB) is a single domain calcium-binding protein and is the smallest members of the calmodulin superfamily, possessing a pair of calcium-binding EF-hands, and structures for all four states have been determined and extensively characterized experimentally. Because of the tremendous advancement in hardware and software computer technologies in recent years, longer and more realistic molecular dynamics (MD) simulations of a protein are possible now in reasonable periods of time. These advances were exploited to generate multiple, all-atom MD simulations of CAB via the AMBER software package, and the resulting trajectories were employed to calculate backbone order parameters of the apo, the singly and the doubly loaded states of calcium in CAB. The results are in very good agreement with corresponding experimental NMR-based (Nuclear Magnetic Resonance spectroscopy) results, and are improved in comparison to those calculated over a decade ago; use of modified force fields played a key role in the observed improvements. The apo state is the most flexible, and the singly loaded and the doubly loaded states are similar, thus supporting positive cooperativity in line with the experimental results. Further, B-factor calculations of backbone atoms for these calcium-binding states of calbindin D9k also support such cooperativity. Although changes in side-chain motions are not necessarily correlated to changes in protein backbone mobility, past studies on the comparison of experimental and simulated methyl side-chain NMR relaxation parameters of CAB for the doubly-loaded state reported significant improvements in the quantitative representation of side-chain motion by MD simulation. In this project, the order parameters for various side chains in apo, singly loaded and doubly loaded states of CAB were calculated. The primary goal of this work was to determine whether or not the allosteric effect of calcium binding, as observed via the backbone order parameters, also extended to the amino acid side chains, and if so, to what extent. Such information could be useful in better understanding the physical basis of cooperative calcium binding in CAB. Most of the residues which provide ligands to bind calcium at the binding sites support positive cooperativity, as observed when Ca-Cß, Cß-C?, C-C bond and C-O bonds of COO groups of aspartic and glutamic acid residues, the C-N bond of the side-chain amide group in asparagine and glutamine residues, and the N-H bonds of amide (NH2) group order parameters were studied. There are only a few residues containing methyl groups that are involved in providing ligands to the calcium, and the studies of order parameters of C-C bond and C-H bond of these methyl groups did not exhibit the cooperativity effect upon calcium binding; the simulated C-C bond order parameter of the methyl group symmetry axis did correlate well with the experimental results for the fully loaded state of CAB (4ICB). Analysis of the MD trajectories using GSATools and MutInf, provided valuable insights into possible pathways for communicating allosteric effects between the two calcium-binding sites of CAB.

A Cost Analysis for Life-Cycle Preventive Maintenance, Administrative Storage, and Condition-Based Maintenance for the U.S. Marine Corps Medium Tactical Vehicle Replacement

DTIC Science & Technology

2013-12-04

Table 3. Monthly PMCS Actions and Labor Required Task Hours Task Hours Inspect cab and hood 1.0 Inspect turbocharger 0.5 Inspect fuel tank 0.1 Inspect...Annual PMCS Actions and Labor Required Task Hours Task Hours Inspect cab and hood 1.0 Air intake system 0.2 Inspect fuel Tank 0.1 Inspect turbocharger

"Dammed Taxi Cab"--How Silent Communication in Questionnaires Can Be Understood and Used to Give Voice to Children's Experiences

ERIC Educational Resources Information Center

Alerby, E.; Kostenius, C.

2011-01-01

"Dammed taxi cab"--a 12-year-old boy wrote these words in the margins of a questionnaire, and within this paper they will serve as a point of departure for the discussion of the use of questionnaires as a way to voice children's experiences. The overall aim of this paper is to enable understanding of and discuss the use of questionnaires as a way…

High speed variable delivery helical screw compressor/expander automotive air conditioning and waste heat energy recovery system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gagnon, J.A.; Schaefer, D.D.; Shaw, D.N.

1980-09-02

A compact, helical screw compressor/expander unit is described that is mounted in a vehicle and connected to the vehicle engine driven drive shaft has inlet and outlet ports and a capacity control slide valve and a pressure matching or volume ratio slide valve, respectively, for said ports. A refrigerant loop includes the compressor, a condenser mounted in the path of air flow over the engine and an evaporator mounted in a fresh air/cab return air flow duct for the occupant. Heat pipes thermally connect the cab air flow duct to the engine exhaust system which also bears the vapor boiler.more » Selectively operated damper valves control the fresh air/cab return air for passage selectively over the evaporator coil and the heat pipes as well as the exhaust gas flow over opposite ends of the heat pipes and the vapor boiler.« less

Cardiac Autonomic Balance vs. Cardiac Regulatory Capacity

PubMed Central

Berntson, Gary G.; Norman, Greg J.; Hawkley, Louise C.; Cacioppo, John T.

2013-01-01

The concept of autonomic balance views autonomic states along a bipolar continuum from sympathetic (S) to parasympathetic (P) dominance, whereas regulatory capacity models emphasize overall autonomic flexibility as a marker of the capacity for regulation. These two concepts were evaluated for their utility in characterizing patterns of autonomic control. Measures of P (high frequency heart rate variability, HF) and S (pre-ejection period, PEP) cardiac control were obtained. A measure of cardiac autonomic balance (CAB) was derived as the difference in the normalized P index minus the S index, and a measure of cardiac autonomic regulation (CAR) was derived as the normalized P index plus the S index. Results reveal that CAR, but not CAB, was a significant predictor of the prior occurrence of a myocardial infarction, net of demographic and other variables, whereas CAB, but not CAR, was a significant predictor of concurrent diabetes. PMID:18282204

Improving a workstation in an existing cab by means of a participatory approach: the case of subway operators' workstations.

PubMed

Bellemare, Marie; Beaugrand, Sylvie; Larue, Christian; Champoux, Danièle

2009-01-01

A study was conducted to identify possible solutions for redesigning a subway cab in order to improve the posture of drivers working in a restricted space. The approach used included the participation of a working group comprised of operations, maintenance, and engineering managers as well as several drivers. After 6 meetings in which different simulation techniques were used, the working group proposed changes for increasing the available space inside the cab and three seat designs. The involvement of the actors from the three departments affected by the changes, as well as the operators, throughout the process, was a determining factor in the advancement and acceptance of the projects. The fact that 400 cars are currently in service and must be modified means that it will take several years to implement the modifications in the entire fleet.

Thermal properties and cycling performance of Ca(BH4)2/MgH2 composite for energy storage

NASA Astrophysics Data System (ADS)

Li, Yang; Li, Ping; Tan, Qiwei; Zhang, Zongliang; Wan, Qi; Liu, Zhiwei; Subramanian, Arunprabaharan; Qu, Xuanhui

2018-05-01

Here we report the thermal properties and cycling performance of Ca(BH4)2/MgH2. The reaction enthalpy is 48 kJ mol-1 H2 and equilibrium pressure at 350 °C is 0.4981 MPa. We add NbF5 into Ca(BH4)2/MgH2to figure out the degradation mechanism because of its catalytic ability. Ca(BH4)2/MgH2 follows the dehydrogenation path to form CaH2, CaB6 and Mg. The degradation of Ca(BH4)2/MgH2 composite during cycling is due to the particle aggregation and the reduction of CaB6 product. NbF5 can promote the forming of CaB6 and prevent microstructural coarsening in Ca(BH4)2/MgH2 during cycling, which leads to better reversibility.

Analysis of Vibration and Noise of Construction Machinery Based on Ensemble Empirical Mode Decomposition and Spectral Correlation Analysis Method

NASA Astrophysics Data System (ADS)

Chen, Yuebiao; Zhou, Yiqi; Yu, Gang; Lu, Dan

In order to analyze the effect of engine vibration on cab noise of construction machinery in multi-frequency bands, a new method based on ensemble empirical mode decomposition (EEMD) and spectral correlation analysis is proposed. Firstly, the intrinsic mode functions (IMFs) of vibration and noise signals were obtained by EEMD method, and then the IMFs which have the same frequency bands were selected. Secondly, we calculated the spectral correlation coefficients between the selected IMFs, getting the main frequency bands in which engine vibration has significant impact on cab noise. Thirdly, the dominated frequencies were picked out and analyzed by spectral analysis method. The study result shows that the main frequency bands and dominated frequencies in which engine vibration have serious impact on cab noise can be identified effectively by the proposed method, which provides effective guidance to noise reduction of construction machinery.

Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals.

PubMed

Perumalla, Sathyanarayana R; Paul, Shubhajit; Sun, Changquan C

2016-06-01

5-Fluorocytosine (FC) is a high-dose antifungal drug that challenges the development of a tablet product due to poor solid-state stability and tabletability. Using 2 pharmaceutically acceptable conjugate acid base (CAB) cocrystals of FC with HCl and acesulfame, we have developed commercially viable high loading FC tablets. The tablets were prepared by direct compression using nano-coated microcrystalline cellulose Avicel PH105 as a tablet binder, which provided both excellent tabletability and good flowability. Commercial manufacturability of formulations based on both CAB cocrystals was verified on a compaction simulator. The results from an expedited friability study were used to set the compaction force, which yielded tablets with sufficient mechanical strength and rapid tablet disintegration. This work demonstrates the potential value of CAB cocrystals in drug product development. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Taxicab tipping and sunlight

PubMed Central

2017-01-01

Does the level of sunlight affect the tipping percentage in taxicab rides in New York City? We examined this question using data on 13.82 million cab rides from January to October in 2009 in New York City combined with data on hourly levels of solar radiation. We found a small but statistically significant positive relationship between sunlight and tipping, with an estimated tipping increase of 0.5 to 0.7 percentage points when transitioning from a dark sky to full sunshine. The findings are robust to two-way clustering of standard errors based on hour-of-the-day and day-of-the-year and controlling for day-of-the-year, month-of-the-year, cab driver fixed effects, weather conditions, and ride characteristics. The NYC cab ride context is suitable for testing the association between sunlight and tipping due to the largely random assignment of riders to drivers, direct exposure to sunlight, and low confounding from variation in service experiences. PMID:28594917

Taxicab tipping and sunlight.

PubMed

Devaraj, Srikant; Patel, Pankaj C

2017-01-01

Does the level of sunlight affect the tipping percentage in taxicab rides in New York City? We examined this question using data on 13.82 million cab rides from January to October in 2009 in New York City combined with data on hourly levels of solar radiation. We found a small but statistically significant positive relationship between sunlight and tipping, with an estimated tipping increase of 0.5 to 0.7 percentage points when transitioning from a dark sky to full sunshine. The findings are robust to two-way clustering of standard errors based on hour-of-the-day and day-of-the-year and controlling for day-of-the-year, month-of-the-year, cab driver fixed effects, weather conditions, and ride characteristics. The NYC cab ride context is suitable for testing the association between sunlight and tipping due to the largely random assignment of riders to drivers, direct exposure to sunlight, and low confounding from variation in service experiences.

Non-Compliance and Follow-Up in Swedish Official and Private Animal Welfare Control of Dairy Cows

PubMed Central

Hultgren, Jan; Röcklinsberg, Helena; Wahlberg, Birgitta

2018-01-01

Simple Summary In many cases, different animal welfare inspections are taking place at an animal farm over time, as the farmer has to comply with both the legislation and with various private standards. In this study, we compared official inspections carried out by CAB (the County Administrative Board, a governmental agency) with private inspections carried out by Arla Foods (a private company) on dairy farms in one Swedish county. For example, we looked at seasonal effects and compared the incidence of different non-compliances. This study shows that long time periods were sometimes allowed for correction, that follow-up systems are diverse, and that there were differences in the inspection result between CAB and Arla due to different focuses during the inspections. Dirty dairy cattle were, however, a common non-compliance found by both CAB and Arla. Tie-stall housing and winter season (Dec–Feb) were risk factors for non-compliance, while the risk was lower for both CAB and Arla to find non-compliances at organic farms compared to conventional farms. We conclude that the presence of both similarities and differences between different control systems underlines the need for transparency, predictability, and clarity of inspections. Abstract Farmers often have to comply with several sets of animal welfare regulations, since private standards have been developed in addition to legislation. Using an epidemiological approach, we analysed protocols from animal welfare inspections carried out in Swedish dairy herds by the County Administrative Board (CAB; official control of legislation) and by the dairy company Arla Foods (private control of Arlagården standard) during 2010–2013 in the county of Västra Götaland. CAB and Arla inspections were not carried out simultaneously. We aimed to identify common non-compliances, quantify risk factors of non-compliance, and investigate if non-compliances were based on animal-, resource-, or management-based requirements, as well as determining the time period allowed for achieving compliance. Non-compliance was found in 58% of CAB cases, and 51% of Arla cases (each case comprising a sequence of one or several inspections). Dirty dairy cattle was one of the most frequent non-compliances in both control systems. However, the differences in control results were large, suggesting a difference in focus between the two systems. Tie-stall housing and winter season (Dec–Feb) were common risk factors for non-compliance, and overall organic farms had a lower predicted number of non-compliances compared to conventional farms. The presence of both similarities and differences between the systems underlines the need for transparency, predictability, and clarity of inspections. PMID:29738491

2016 availability and disparity study : final report.

DOT National Transportation Integrated Search

2016-07-01

The study examined whether there was a level playing field for minority- and women-owned firms in the Montana transportation : contracting marketplace and for MDT contracting. This information helps MDT set an overall goal for Disadvantage Business :...

Analysis of Commercial Contract Training for the Navy (Phase II) [And] Commercial Contract Training Navy Area VOTEC Support Center (AVSC) Guidelines. Final Report.

ERIC Educational Resources Information Center

Copeland, D. Robert; And Others

The two-part report describing the Phase 2 findings of a two-phase study demonstrates the utility of the commercial contract training concept for satisfying certain Navy skill training requirements. Part 1 concerns source evaluation, skill analysis and selection, contractual considerations, and comparative training capability evaluation. It…

Medicare and state health care programs: fraud and abuse, civil money penalties and intermediate sanctions for certain violations by health maintenance organizations and competitive medical plans--HHS. Final rule.

PubMed

1994-07-15

This final rule implements sections 9312(c)(2), 9312(f), and 9434(b) of Public Law 99-509, section 7 of Public Law 100-93, section 4014 of Public Law 100-203, sections 224 and 411(k)(12) of Public Law 100-360, and section 6411(d)(3) of Public Law 101-239. These provisions broaden the Secretary's authority to impose intermediate sanctions and civil money penalties on health maintenance organizations (HMOs), competitive medical plans, and other prepaid health plans contracting under Medicare or Medicaid that (1) substantially fail to provide an enrolled individual with required medically necessary items and services; (2) engage in certain marketing, enrollment, reporting, or claims payment abuses; or (3) in the case of Medicare risk-contracting plans, employ or contract with, either directly or indirectly, an individual or entity excluded from participation in Medicare. The provisions also condition Federal financial participation in certain State payments on the State's exclusion of certain prohibited entities from participation in HMO contracts and waiver programs. This final rule is intended to significantly enhance the protections for Medicare beneficiaries and Medicaid recipients enrolled in a HMO, competitive medical plan, or other contracting organization under titles XVIII and XIX of the Social Security Act.

Support of the Laboratory for Terrestrial Physics for Dynamics of the Solid Earth (DOSE)

NASA Technical Reports Server (NTRS)

Vandenberg, Nancy R.; Ma, C. (Technical Monitor)

2001-01-01

This final report summarizes the accomplishments during the contract period. Under the contract NVI, Inc. provided support to the VLBI group at NASA's Goddard Space Flight Center. The contract covered a period of approximately eight years during which geodetic and astrometric VLBI evolved through several major changes. This report is divided into four sections which correspond to major task areas in the contract: A) Coordination and Scheduling, B) Field System, C) Station Support, and D) Analysis and Research and Development.

Support for the Laboratory for Terrestrial Physics for Dynamics of the Solid Earth (DOSE)

NASA Technical Reports Server (NTRS)

Ma, C. (Technical Monitor)

2001-01-01

This final report summarizes the accomplishments during the contract period. Under the contract NVI, Inc. provided support to the VLBI group at NASA's Goddard Space Flight Center. The contract covered a period of approximately eight years during which geodetic and astrometric VLBI evolved through several major changes. This report is divided into four sections which correspond to major task areas in the contract: A) Coordination and Scheduling, B) Field System, C) Station Support, and D) Analysis and Research and Development.

Defense Department Profit and Contract Finance Policies and Their Effects on Contract and Contractor Performance

DTIC Science & Technology

2008-02-01

liabilities (e.g., accounts payable). This ratio can be compared to the firm’s weighted average cost of capital ( WACC ). WACC is the cost of debt plus the cost...RatioCost of Debt Marginal Tax Rate Risk-Free Rate Cost of Equity Risk Premium Industry Beta WACC Technical Risk CPFF/CPAF …. FFP/ MYP - Contract Choice...estimates the levered WACC as the discount rate, and finally calculates the NPV of the contract. Specific model input includes profit policy levers

Defense Department Profit and Contract Finance Policies and Their Effects on Contract and Contractor Performance

DTIC Science & Technology

2009-02-01

cost of capital ( WACC ). WACC is the cost of debt plus the cost of equity both weighted by the market values debt and equity, respectively. The cost...Beta WACC Technical Risk CPFF/CPAF …. FFP/ MYP - Contract Choice (FAR 16.1) Margin – (p = f(NBV, n, α, risk)) Payments (α) FCOM ( = f(NBV, Treasury...projections, layers on the profit and contract financing policy, estimates the levered WACC as the discount rate, and finally calculates the NPV of the

Imaging cerebral activity in recovery from chronic traumatic brain injury: a preliminary report.

PubMed

Lewis, David H; Bluestone, Judith P; Savina, Maryann; Zoller, William H; Meshberg, Emily B; Minoshima, Satoshi

2006-07-01

People in chronic phase of traumatic brain injury (TBI) are often told that there will be no further recovery in brain function, that they are in a "static phase." Holistic Approach to NeuroDevelopment and Learning Efficiency (HANDLE), an alternative therapy, aims to improve function by teaching a series of physical and mental activities that clients perform and encouraging changes in lifestyle. Five subjects (3 males) with chronic TBI (at least 3 years since ictus) completed the HANDLE Institute's program and were prospectively evaluated. Each had six regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) scans over 7 months (scans n= 30). Paired scans were performed with injection of Tc-99m ECD to image rCBF at rest and during the HANDLE "Crossed Arm Bounce" (CAB) exercise before the program, at 3-4 months into the program, and at 6-7 months, after the program had ended. SPECT images were analyzed statistically using Neurostat in which image sets were coregistered and warped into Talaraich atlas for pairwise subtraction between conditions. Group analysis of SPECT showed that CAB activated (increased rCBF) vermis and cerebellar hemispheres in first two paired scans and anterior cingulate and vermis on the final pair. Increased rCBF at rest occurred in cerebellar hemispheres, vermis, and right dorsomedial frontal cortex. These preliminary observations suggest that there may be a role of the hindbrain (vermis and cerebellum) with HANDLE treatment of chronic TBI.

48 CFR 2936.516 - Quality surveys.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Quality surveys. 2936.516... REQUIREMENTS CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 2936.516 Quality surveys. The HCA... original and final surveys as prescribed in FAR 36.516. ...

48 CFR 2936.516 - Quality surveys.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Quality surveys. 2936.516... REQUIREMENTS CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 2936.516 Quality surveys. The HCA... original and final surveys as prescribed in FAR 36.516. ...

48 CFR 2936.516 - Quality surveys.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Quality surveys. 2936.516... REQUIREMENTS CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 2936.516 Quality surveys. The HCA... original and final surveys as prescribed in FAR 36.516. ...

48 CFR 2936.516 - Quality surveys.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Quality surveys. 2936.516... REQUIREMENTS CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 2936.516 Quality surveys. The HCA... original and final surveys as prescribed in FAR 36.516. ...

48 CFR 2936.516 - Quality surveys.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Quality surveys. 2936.516... REQUIREMENTS CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 2936.516 Quality surveys. The HCA... original and final surveys as prescribed in FAR 36.516. ...

Seasonal variability in size-segregated airborne bacterial particles and their characterization at different source-sites.

PubMed

Agarwal, Smita

2017-05-01

Size-segregated aerosol samplings were carried out near the potential sources of airborne biological particles i.e. at a landfill site, an agricultural field and a road side restaurant-cluster site in winter, spring and summer seasons during 2013-2015 in New Delhi. The culturable airborne bacterial (CAB) concentrations showed significant seasonal variation from higher to moderate in spring and winter seasons and lowest during summer. Highest CAB concentrations were observed at the Okhla landfill site followed by restaurant-cluster area and agriculture site. The CAB particles showed bimodal size distribution, abundant in the size ranges of 1.1-2.1, 2.1-3.3 and 4.7-5.8 μm. However, substantial concentrations were also observed in the size bins of 0.43-0.65 and <0.43 μm, which are important for cloud condensation nuclei (CCN) activity of aerosols in addition to their adverse health effects. In spring, bacterial particles were also maximized in size ranges between 5.8 and >9.0 μm. Fine mode proportions of CAB were found to be higher in winter than other two seasons. Bacterial identification was done by 16s rDNA sequencing, and most abundant identified strains were Bacillus cereus (16%), Bacillus licheniformis (11%), Bacillus thuringiensis (9%), Micrococcus sp. (7%) and Acinetobacter sp. (9%).

Triage Decision Trees and Triage Protocols: Changing Strategies for Medical Rescue in Civilian Mass Casualty Situations.

DTIC Science & Technology

1984-02-06

MASS CASUALTY SITUATIONS FINAL REPORT for 0O FEDERAL EMERGENCY MANAGEMENT AGENCY WASHINGTON, D.C. 20472 FEMA CONTRACT NUMBER EMW-C-1202 e FEMA WORK UNIT...20006 FINAL REPORT for FEDERAL EMERGENCY MANAGEMENT AGENCY WASHINGTON, D.C. 20472 FEMA CONTRACT NUMBER EMW-C-1202 FEMA WORK UNIT NUMBER 2412G...February 1984 This repnrt has been reviewed in the Federal Emergency Management Agency and approved for publication. Approval does not signify that the

An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

DTIC Science & Technology

2015-06-01

occasioned by numerous, rhythmic high pressure non-voiding contractions (NVC) during normal bladder filling. These NVC are responsible for incontinence...month experiment period) 2c. Final data analysis (data analysis will be ongoing throughout, this will represent the finalization of data period, 0.25...Sub-Tasks 2a and 2b. As of 9/2/14, we have completed much of the data analysis (Sub-Task 2c; see below for results). Analysis of abdominal

Analysis of Commercial Contract Training for the Marine Corps (Phase II) [And] Commercial Contract Training Marine Corps Area VOTEC Support Center (AVSC) Guidelines. Final Report.

ERIC Educational Resources Information Center

Copeland, D. Robert; And Others

The two-part report describing the Phase 2 findings of a two-phase study demonstrates the utility of the commercial contract training concept for satisfying certain Marine Corps skill training requirements. Part 1 concerns source evaluation, skill analysis and selection, contractual considerations, and comparative training capability evaluation.…

Claims for Unabsorbed Overhead on Defense Contracts.

DTIC Science & Technology

1985-09-01

coat which, under the provisions of any pertinent law, regulation, or contract, cannot be included in prices, cost reimbureements , or settlements...ruled that the contractor was due some reimbursement . " - Allegheny appealed the contracting officer’s determination a second time questioning how much...amount of reimbursement . The final opinion also added the cost that was substantiated for replacement of operators and make-up pay. Therefore, the

Age 60 study, part III : consolidated database experiments final report.

DOT National Transportation Integrated Search

1994-10-01

This document is one of four products completed as a part of the Age 60 Rule research contract monitored by Pam Della Rocco, Civil Aerospace Medical Institute, Contracting Officer's Technical Representative. This work was performed. This report was a...

48 CFR 42.603 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Responsibilities. (a) The CACO shall perform, on a corporate-wide basis, the contract administration functions as designated by the responsible agency. Typical CACO functions include (1) the determination of final indirect cost rates for cost-reimbursement contracts, (2) establishment of advance agreements or recommendations...

Lanthanide, yttrium, and zirconium anomalies in the Fire Clay coal bed, Eastern Kentucky

USGS Publications Warehouse

Hower, J.C.; Ruppert, L.F.; Eble, C.F.

1999-01-01

The Fire Clay coal bed in the Central Appalachian basin region contains a laterally-persistent tonstein that is found in the coal throughout most of its areal extent. The tonstein contains an array of minerals, including sanidine, ??-quartz, anatase and euhedral zircon, thhat constitutes strong evidence for a volcanic origin of the parting. For this study, five samples of the tonstein and four sets of coal samples underlying the tonstein were collected from five sites in eastern Kentucky. Inductively coupled plasma-mass spectroscopy (ICP-MS) analysis of the tonstein and underlying coal collected from four sites in eastern Kentucky show that although Zr concentrations are high in the tonstein (570-1820 ppm on a coal-ash basis (cab)), they are highest in the coal directly underlying the tonstein (2870-4540 ppm (cab)). A similar enrichment pattern is observed in the concentration of Y plus the sum of the rare earth elements (Y + ??REE): total Y + ??REE concentrations in the five tonstein samples range from 511 to 565 ppm (cab). However, Y + ??REE contents are highest in the coals directly underlying the tonsteins: values range from 1965 to 4198 ppm (cab). Scanning electron microscopy of samples from coal which directly underlies two of the tonstein samples show that REE-rich phosphate, tentatively identified as monazite, commonly infills cracks in clays and cells in clarain and vitrain. Zircon is rare and commonly subhedral. On the basis of coal chemistry and grain morphology, we suggest that volcanic components in the tonstein were leached by ground water. The leachate, rich in Y and REE precipitated as authigenic mineral phases in the underlying coal.The Fire Clay coal bed in the Central Appalachian basin region contains a laterally-persistent tonstein that is found in the coal throughout most of its areal extent. The tonstein contains an array of minerals, including sanidine, ??-quartz, anatase and euhedral zircon, that constitutes strong evidence for a volcanic origin of the parting. For this study, five samples of the tonstein and four sets of coal samples underlying the tonstein were collected from five sites in eastern Kentucky. Inductively coupled plasma-mass spectroscopy (ICP-MS) analysis of the tonstein and underlying coal collected from four sites in eastern Kentucky show that although Zr concentrations are high in the tonstein (570-1820 ppm on a coal-ash basis (cab)), they are highest in the coal directly underlying the tonstein (2870-4540 ppm (cab)). A similar enrichment pattern is observed in the concentration of Y plus the sum of the rare earth elements (Y+???REE): total Y+???REE concentrations in the five tonstein samples range from 511 to 565 ppm (cab). However, Y+???REE contents are highest in the coals directly underlying the tonsteins: values range from 1965 to 4198 ppm (cab). Scanning electron microscopy of samples from coal which directly underlies two of the tonstein samples show that REE-rich phosphate, tentatively identified as monazite, commonly infills cracks in clays and cells in clarain and vitrain. Zircon is rare and commonly subhedral. On the basis of coal chemistry and grain morphology, we suggest that volcanic components in the tonstein were leached by ground water. The leachate, rich in Y and REE precipitated as authigenic mineral phases in the underlying coal.

DEMOLISHING A COLD WARE ERA FULE STORAGE BASIN SUPERSTRUCTURE LADEN WITH ASBESTOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

LLOYD ER; STEVENS JM; DAGAN EB

The K East (KE) Basin facilities are located near the north end of the Hanford Site's 100 K area. The facilities were built in 1950 as part of the KE Reactor complex and constructed within 400 meters of the Columbia River, which is the largest river in the Pacific Northwest and by volume the fourth largest river in the United States. The basin, located adjacent to the reactor, was used for the underwater storage of irradiated nuclear fuel discharged from the reactor. The basin was covered by a superstructure comprising steel columns and beams, concrete, and cement asbestos board (CAB)more » siding. The project's mission was to complete demolition of the structure over the KE Basin within six months of turnover from facility deactivation activities. The demolition project team applied open-air demolition techniques to bring the facility to slab-on-grade. Several innovative techniques were used to control contamination and maintain contamination control within the confines of the demolition exclusion zone. The techniques, which focused on a defense-in-depth approach, included spraying fixatives on interior and exterior surfaces before demolition began; applying fixatives during the demolition; misting using a fine spray of water during demolition; and demolishing the facility systematically. Another innovative approach that made demolition easier was to demolish the building with the non-friable CAB remaining in place. The CAB siding covered the exterior of the building and portions of the interior walls, and was an integral part of the multiple-layered roof. The project evaluated the risks involved in removing the CAB material in a radiologically contaminated environment and determined that radiological dose rates and exposure to radiological contamination and industrial hazards would be significantly reduced by using heavy equipment to remove the CAB during demolition. The ability to perform this demolition safely and without spreading contamination (radiological or asbestos) demonstrates that contaminated structures can be torn down successfully using similar open-air demolition techniques.« less

DEMOLISHING A COLD-WAR-ERA FUEL STORAGE BASIN SUPERSTRUCTURE LADEN WITH ASBESTOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

LLOYD ER; ORGILL TK; DAGAN EB

The K East (KE) Basin facilities are located near the north end of the Hanford Site's 100 K area. The facilities were built in 1950 as part of the KE Reactor complex and constructed within 400 meters of the Columbia River, which is the largest river in the Pacific Northwest and by volume the fourth largest river in the United States. The basin, located adjacent to the reactor, was used for the underwater storage of irradiated nuclear fuel discharged from the reactor. The basin was covered by a superstructure comprising steel columns and beams, concrete, and cement asbestos board (CAB)more » siding. The project's mission was to complete demolition of the structure over the K East basin within six months of tumover from facility deactivation activities. The demolition project team implemented open-air demolition techniques to demolish the facility to slab-on-grade. Several innovative techniques were used to control contamination and maintain contamination control within the confines of the demolition exclusion zone. The techniques, which focused on a defense-in-depth approach, included spraying fixatives on interior and exterior surfaces before demolition began; applying fixatives; misting using a fine spray of water during demolition; and demolishing the facility systematically. Another innovation that aided demolition was to demolish the building with the non-friable CAB remaining in place. The CAB siding covered the exterior of the building, portions of the interior walls, and was an integral part of the multiple layered roof. The project evaluated the risks involved in removing the CAB material in a radiologically contaminated environment and determined that radiological dose rates and exposure to radiological contamination and industrial hazards would be significantly reduced by removing the CAB during demolition using heavy equipment. The ability to perform this demolition safely and without spreading contamination (radiological or asbestos) demonstrates that similar open-air demolition ofcontaminated structures can be performed successfully.« less

Top-down estimate of methane emissions in California using a mesoscale inverse modeling technique: The South Coast Air Basin

DOE PAGES

Cui, Yu Yan; Brioude, Jerome; McKeen, Stuart A.; ...

2015-07-28

Methane (CH 4) is the primary component of natural gas and has a larger global warming potential than CO 2. Some recent top-down studies based on observations showed CH 4 emissions in California's South Coast Air Basin (SoCAB) were greater than those expected from population-apportioned bottom-up state inventories. In this study, we quantify CH 4 emissions with an advanced mesoscale inverse modeling system at a resolution of 8 km × 8 km, using aircraft measurements in the SoCAB during the 2010 Nexus of Air Quality and Climate Change campaign to constrain the inversion. To simulate atmospheric transport, we use themore » FLEXible PARTicle-Weather Research and Forecasting (FLEXPART-WRF) Lagrangian particle dispersion model driven by three configurations of the Weather Research and Forecasting (WRF) mesoscale model. We determine surface fluxes of CH 4 using a Bayesian least squares method in a four-dimensional inversion. Simulated CH4 concentrations with the posterior emission inventory achieve much better correlations with the measurements (R2 = 0.7) than using the prior inventory (U.S. Environmental Protection Agency's National Emission Inventory 2005, R 2 = 0.5). The emission estimates for CH 4 in the posterior, 46.3 ± 9.2 Mg CH 4/h, are consistent with published observation-based estimates. Changes in the spatial distribution of CH 4 emissions in the SoCAB between the prior and posterior inventories are discussed. Missing or underestimated emissions from dairies, the oil/gas system, and landfills in the SoCAB seem to explain the differences between the prior and posterior inventories. Furthermore, we estimate that dairies contributed 5.9 ± 1.7 Mg CH 4/h and the two sectors of oil and gas industries (production and downstream) and landfills together contributed 39.6 ± 8.1 Mg CH 4/h in the SoCAB.« less

Influence of curing mode with a LED unit on polymerization contraction kinetics and degree of conversion of dental resin-based materials.

PubMed

Mortier, Eric; Simon, Yorick; Dahoun, Abdelsellam; Gerdolle, David

2009-01-01

The purpose of this study was to evaluate the influence of photopolymerization mode with a light emitting diode (LED) lamp on the curing contraction kinetics and degree of conversion of 3 resin-based restorative materials. The curing contraction kinetics of Admira (ADM), Filtek P60 (P60), and Filtek Flow (FLO) were measured by the glass slide method. The materials were exposed to light from a 1,000 mW/cm-(2) power LED lamp (Elipar Freelight 2) in 3 modes: 2 continuous modes of 20 and 40 seconds (C20 and C40), and 1 exponential mode (E20; 5 seconds of exponential power increase followed by 15 seconds of maximum intensity). The degree of conversion (DC) was measured for each of the materials, and each of the modes by Fourier transformed infra-red spectrometry. P60 had the significantly lowest final contraction and FLO the highest among all light exposure modes. The C20 and C40 modes did not produce any difference in contraction or degree of conversion. The E20 mode led to a significant slowing of contraction speed combined with greater final contraction. Use of a LED lamp (1,000 mW/cm2) in continuous mode reduces the exposure time by half for identical curing shrinkage and degree of conversion.

Particle damping applied research on mining dump truck vibration control

NASA Astrophysics Data System (ADS)

Song, Liming; Xiao, Wangqiang; Guo, Haiquan; Yang, Zhe; Li, Zeguang

2018-05-01

Vehicle vibration characteristics has become an important evaluation indexes of mining dump truck. In this paper, based on particle damping technology, mining dump truck vibration control was studied by combining the theoretical simulation with actual testing, particle damping technology was successfully used in mining dump truck cab vibration control. Through testing results analysis, with a particle damper, cab vibration was reduced obviously, the methods and basis were provided for vehicle vibration control research and particle damping technology application.

41 CFR 60-30.30 - Final Administrative Order.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requiring the contractor to provide whatever remedies are appropriate, and imposing whatever sanctions are... in the immediate cancellation, termination and suspension of the respondent's contracts and/or debarment of the respondent from further contracts. [61 FR 19988, May 3, 1996] Expedited Hearing Procedures...

Towards a Theory for Combining Information From Related Experiments

DTIC Science & Technology

2002-11-11

TITLE AND SUBTITLE Final Report on ARO Contract # DAAD 19-99-1- 1082 entitled “Towards a theory for combining information from related...Contract # DAAD 19-99-1- 1082 4. AUTHOR OF THE REPORT: Francisco J. Samaniego, Principal Investigator 5. PERFPORMING ORGANIZATION: University of...preparation under the support of ARO Contract # DAAD 19-99-1- 1082 [1] "Linear Data Fusion", Proceedings of the Fourth Army Conference on Applied

Review of Department Identified Contracts and Grants for Public Relations Services. Final Inspection Report. ED-OIG/I13-F0012

ERIC Educational Resources Information Center

US Department of Education, 2005

2005-01-01

The objective of this inspection was to review the materials produced under 20 contracts and 15 grants issued by the Department of Education (Department) to determine whether any of the contracts and grants resulted in covert propaganda. It has been concluded that none of the grants resulted in covert propaganda under the existing guidance of the…

Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether-Linked Nitramines

DTIC Science & Technology

2016-07-01

ARL-TR-7706 ● JULY 2016 US Army Research Laboratory Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether...JULY 2016 US Army Research Laboratory Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether-Linked Nitramines by...YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) July 2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) Fiscal Year 2013 4. TITLE

Managed care contracting: a systematic approach.

PubMed

Flores, K

1987-12-01

Managed care is sweeping the health care industry and has produced some special challenges for providers. Success in contracting depends on preparation. In this article, the author defines managed care and outlines who should be involved in the contracting for these services. Special attention is given to how to develop the appropriate internal support. The author contends that a provider should not embrace all contracting offers and suggests criteria for selection of the best offers. Finally, the prevailing pricing schemes are reviewed and caveats given on their interpretation and use.

Support of the Laboratory for Terrestrial Physics for Dynamics of the Solid Earth (DOSE)

NASA Technical Reports Server (NTRS)

Vandenberg, N. R.; Ma, C. (Technical Monitor)

2002-01-01

This final report summarizes the accomplishments during the contract period. Under the contract Nepal, Inc. provided support to the VLBI group at NASA's Goddard Space Flight Center. The contract covered a period of approximately eight years during high geodetic and astrometric VLBI evolved through several major changes. This report is divided into five sections that correspond to major task areas in the contract: A) Coordination rid Scheduling, B) Field System, CN Station Support, D) Analysis and Research and Development, and E) Computer Support.

Global remote sensing of water-chlorophyll ratio in terrestrial plant leaves.

PubMed

Kushida, Keiji

2012-10-01

I evaluated the use of global remote sensing techniques for estimating plant leaf chlorophyll a + b (C(ab); μg cm(-2)) and water (C(w); mg cm(-2)) concentrations as well as the ratio of C(w)/C(ab) with the PROSAIL model under possible distributions for leaf and soil spectra, leaf area index (LAI), canopy geometric structure, and leaf size. First, I estimated LAI from the normalized difference vegetation index. I found that, at LAI values <2, C(ab), C(w), and C(w)/C(ab) could not be reliably estimated. At LAI values >2, C(ab) and C(w) could be estimated for only restricted ranges of the canopy structure; however, the ratio of C(w)/C(ab) could be reliably estimated for a variety of possible canopy structures with coefficients of determination (R(2)) ranging from 0.56 to 0.90. The remote estimation of the C(w)/C(ab) ratio from satellites offers information on plant condition at a global scale.

Assessment of Plant-Probiotic Performance of Novel Endophytic Bacillus sp. in Talc-Based Formulation.

PubMed

Basheer, Jasim; Ravi, Aswani; Mathew, Jyothis; Krishnankutty, Radhakrishnan Edayileveettil

2018-01-25

Endophytic bacteria are considered to have a plethora of plant growth promoting and anti-phytopathogenic traits to live within the plants. Hence, they have immense promises for plant probiotic development. In the current study, plant probiotic endophytic Bacillus sp. CaB5 which has been previously isolated from Capsicum annuum was investigated for its performance in talc-based formulation. For this, CaB5 was made into formulation with sterile talc, calcium carbonate, and carboxymethyl cellulose. The viability analysis of the formulation by standard plate count and fluorescence methods has confirmed the stable microbial count up to 45 days. Plant probiotic performance of the prepared formulation was analyzed on cowpea (Vigna unguiculata) and lady's finger (Abelmoschus esculentus). The results showed the formulation treatment to have enhancement effect on seed germination as well as plant growth in both selected plants. The results highlight the potential of CaB5-based formulation for field application to enhance growth of economically important plants.

Pet dogs and child physical activity: the role of child-dog attachment.

PubMed

Gadomski, A M; Scribani, M B; Krupa, N; Jenkins, P

2017-10-01

Dog ownership has been associated with increased physical activity in children which in turn may mitigate childhood obesity. To measure the association between child-dog attachment and child physical activity and screen time. Cross-sectional study including 370 children (ages 4-10) who had pet dogs in the home. Parents completed the DartScreen, a web-based screener, before a well-child visit. Screener domains included child body mass index (BMI), physical activity, screen time and dog-related questions. The Companion Animal Bonding Scale (CABS) was used to measure child attachment to the dog. Clinic nurses weighed and measured the children. Associations between CABS, BMI z-score, screen time and physical activity were estimated. CABS was strongly associated with time spent being active with the dog (F = 22.81, p < 0.0001), but not with BMI z-score or screen time. A higher level of child attachment to a pet dog is associated with increased child physical activity. © 2016 World Obesity Federation.

Synergism and Physicochemical Properties of Anionic/Amphoteric Surfactant Mixtures with Nonionic Surfactant of Amine Oxide Type

NASA Astrophysics Data System (ADS)

Blagojević, S. M.; Pejić, N. D.; Blagojević, S. N.

2017-12-01

The physicochemical properties of initial formulation, that is anionic/amphoteric surfactants mixture SLES/AOS/CAB (sodium lauryl ether sulfate (SLES), α-olefin sulfonates (AOS) and cocamidopropyl betaine (CAB) at ratio 80 : 15 : 5) with nonionic surfactant of amine oxide type (lauramine oxide (AO)) in various concentration (1-5%) were studied. To characterize the surfactants mixture, the critical micelle concentration (CMC), surface tension (γ), foam volume, biodegradability and irritability were determined. This study showed that adding of AO in those mixtures lowered both γ and CMC as well as enhanced SLES/AOS/CAB foaming properties, but did not significantly affect biodegradability and irritability of initial formulation. Moreover, an increase in AO concentration has a meaningful synergistic effect on the initial formulation properties. All those results indicates that a nonionic surfactant of amine oxide type significantly improves the performance of anionic/amphoteric mixed micelle systems, and because of that anionic/amphoteric/nonionic mixture can be used in considerably lower concentrations as a cleaning formulation.

14 CFR 17.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrator of the Federal Aviation Administration. (e) Alternative Dispute Resolution (ADR) is the primary... issuance of a Contracting Officer final decision. Contract disputes for purposes of ADR only may also... communication or the use of ADR. The Default Adjudicative Process is conducted by a DRO or Special Master...

48 CFR 31.202 - Direct costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.202 Direct... amount as an indirect cost if the accounting treatment— (1) Is consistently applied to all final cost... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Direct costs. 31.202...

48 CFR 42.704 - Billing rates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Billing rates. 42.704... CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.704 Billing rates. (a) The contracting... final indirect cost rates also shall be responsible for determining the billing rates. (b) The...

48 CFR 42.704 - Billing rates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Billing rates. 42.704... CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.704 Billing rates. (a) The contracting... final indirect cost rates also shall be responsible for determining the billing rates. (b) The...

48 CFR 42.704 - Billing rates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Billing rates. 42.704... CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.704 Billing rates. (a) The contracting... final indirect cost rates also shall be responsible for determining the billing rates. (b) The...

48 CFR 42.704 - Billing rates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Billing rates. 42.704... CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.704 Billing rates. (a) The contracting... final indirect cost rates also shall be responsible for determining the billing rates. (b) The...

48 CFR 1552.242-72 - Financial administrative contracting officer.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Negotiate advance agreements applicable to treatment of costs and to Independent Research & Development/Bid and Proposal costs. (3) Negotiate changes to interim billing rates and establish final indirect cost... contracting officer. 1552.242-72 Section 1552.242-72 Federal Acquisition Regulations System ENVIRONMENTAL...

North American study on contracting snow and ice response : final report.

DOT National Transportation Integrated Search

2017-01-01

Snow and ice control operations are a vital function often conducted by state and local transportation agencies. Many states are choosing to contract snow and ice response services, instead of or in addition to the use of in-house forces, to maintain...

Student nurses' experiences of using a learning contract as a method of assessment.

PubMed

Bailey, Maria E; Tuohy, Dympna

2009-10-01

The purpose of this study was to describe final year undergraduate nurses' experiences of assessment through the use of a learning contract. Using a qualitative descriptive design, data was collected from a purposive sample of final (fourth) year undergraduate student nurses. Two approaches were taken for data collection, anonymous evaluative questionnaires and interviews. The study was approved by the local university research and ethics committee. Data was thematically analysed. This article presents and discusses the findings from the interviews. Findings suggest that students' approach to the assessment strategy influenced engagement with the learning contract. Three themes were identified: skills, perceptions, and actions. Within these themes three types of learner were identified: happy, pragmatic and fearful. Factors found to influence successful completion of the learning contract were: support, relevant skills, prior experiential learning and required theoretical knowledge. Recommendations include the need for educators to consider module assessments that recognise the learning needs and preferences of the student within a supportive environment.

Thermodynamic, Kinetic, and Equilibrium Parameters for the Removal of Lead and Cadmium from Aqueous Solutions with Calcium Alginate Beads

PubMed Central

Alfaro-Cuevas-Villanueva, Ruth; Hidalgo-Vázquez, Aura Roxana; Cortés Penagos, Consuelo de Jesús; Cortés-Martínez, Raúl

2014-01-01

The sorption of cadmium (Cd) and lead (Pb) by calcium alginate beads (CAB) from aqueous solutions in batch systems was investigated. The kinetic and thermodynamic parameters, as well as the sorption capacities of CAB in each system at different temperatures, were evaluated. The rate of sorption for both metals was rapid in the first 10 minutes and reached a maximum in 50 minutes. Sorption kinetic data were fitted to Lagergren, pseudo-second-order and Elovich models and it was found that the second-order kinetic model describes these data for the two metals; comparing kinetic parameters for Cd and Pb sorption a higher kinetic rate (K 2) for Pb was observed, indicating that the interaction between lead cations and alginate beads was faster than for cadmium. Similarly, isotherm data were fitted to different models reported in literature and it was found that the Langmuir-Freundlich (L-F) and Dubinin-Radushkevich (D-R) models describe the isotherms in all cases. CAB sorption capacity for cadmium was 27.4 mg/g and 150.4 mg/g for lead, at 25°C. Sorption capacities of Cd and Pb increase as temperature rises. According to the thermodynamic parameters, the cadmium and lead adsorption process was spontaneous and endothermic. It was also found that pH has an important effect on the adsorption of these metals by CAB, as more were removed at pH values between 6 and 7. PMID:24587740

What are the fluxes of greenhouse gases from the greater Los Angeles area as inferred from top-down remote sensing studies?

NASA Astrophysics Data System (ADS)

Hedelius, J.; Wennberg, P. O.; Wunch, D.; Roehl, C. M.; Podolske, J. R.; Hillyard, P.; Iraci, L. T.

2017-12-01

Greenhouse gas (GHG) emissions from California's South Coast Air Basin (SoCAB) have been studied extensively using a variety of tower, aircraft, remote sensing, emission inventory, and modeling studies. It is impractical to survey GHG fluxes from all urban areas and hot-spots to the extent the SoCAB has been studied, but it can serve as a test location for scaling methods globally. We use a combination of remote sensing measurements from ground (Total Carbon Column Observing Network, TCCON) and space-based (Observing Carbon Observatory-2, OCO-2) sensors in an inversion to obtain the carbon dioxide flux from the SoCAB. We also perform a variety of sensitivity tests to see how the inversion performs using different model parameterizations. Fluxes do not significantly depend on the mixed layer depth, but are sensitive to the model surface layers (<5 m). Carbon dioxide fluxes are larger than those from bottom-up inventories by about 20%, and along with CO has a significant weekend:weekday effect. Methane fluxes have little weekend changes. Results also include flux estimates from sub-regions of the SoCAB. Larger top-down than bottom-up fluxes highlight the need for additional work on both approaches. Higher top-down fluxes could arise from sampling bias, model bias, or may show bottom-up values underestimate sources. Lessons learned here may help in scaling up inversions to hundreds of urban systems using space-based observations.

Mobile Geochemistry Instrument Package Facility (MGIPF) for In Situ Mineralogical and Chemical Analysis of Planetary Surface Material

NASA Astrophysics Data System (ADS)

Klingelhöfer, G.; Romstedt, J.; Henkel, H.; Michaelis, H.; Brückner, J.; D'Uston, C.

A first order requirement for any spacecraft mission to land on a solid planetary or moon surface is instrumentation for in-situ mineralogical and chemical analysis 2 Such analysis provide data needed for primary classification and characterization of surface materials present We will discuss a mobile instrument package we have developed for in-situ investigations under harsh environmental conditions like on Mercury or Mars This Geochemistry Instrument Package Facility is a compact box also called payload cab containing three small advanced geochemistry mineralogy instruments the chemical spectrometer APXS the mineralogical M o ssbauer spectrometer MIMOS II 3 and a textural imager close-up camera The payload cab is equipped with two actuating arms with two degrees of freedom permitting precision placement of all instruments at a chosen sample This payload cab is the central part of the small rover Nanokhod which has the size of a shoebox 1 The Nanokhod rover is a tethered system with a typical operational range of sim 100 m Of course the payload cab itself can be attached by means of its arms to any deployment device of any other rover or deployment device 1 Andre Schiele Jens Romstedt Chris Lee Sabine Klinkner Rudi Rieder Ralf Gellert G o star Klingelh o fer Bodo Bernhardt Harald Michaelis The new NANOKHOD Engineeering model for extreme cold environments 8th International symposium on Artificial Intelligence Robotics and Automation in Space 5 - 9 September 2005

Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 2, Appendices A--L.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

1992-01-01

This report consists of appendices A-L of the final environmental impact statement for the Bonneville Power Administration. The appendices provide information on the following: Ninth circuit Court opinion in Forelaws on Board v. Johnson; guide to Northwest Power act contracts; guide to hydro operations; glossary; affected environment supporting documentation; environmental impacts of generic resource types; information on models used; technical information on analysis; public involvement activities; bibliography; Pacific Northwest Electric Power Planning and Conservation Act; and biological assessment. (CBS)

An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

DTIC Science & Technology

2014-10-01

SCI) is often occasioned by numerous, rhythmic high pressure non-voiding contractions (NVC) during normal bladder filling. These NVC are...addition to the 16.5 month experiment period) 2c. Final data analysis (data analysis will be ongoing throughout, this will represent the finalization...accomplished. We accomplished Sub-Tasks 2a and 2b. As of 9/2/14, we have completed much of the data analysis (Sub-Task 2c; see below for results). Analysis

Special environmental control and life support equipment test analyses and hardware

NASA Technical Reports Server (NTRS)

Callahan, David M.

1995-01-01

This final report summarizes NAS8-38250 contract events, 'Special Environmental Control and Life Support Systems Test Analysis and Hardware'. This report is technical and includes programmatic development. Key to the success of this contract was the evaluation of Environmental Control and Life Support Systems (ECLSS) test results via sophisticated laboratory analysis capabilities. The history of the contract, including all subcontracts, is followed by the support and development of each Task.

48 CFR 52.216-7 - Allowable Cost and Payment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... last disclosure of internal audit reports to the Government. (J) Annual internal audit plan of...-contract cost allowability limitations, and billing limitations. (v) The Contractor shall update the billings on all contracts to reflect the final settled rates and update the schedule of cumulative direct...

Tri-level study of the causes of traffic accidents. Volume 1, Causal factor tabulations and assessments

DOT National Transportation Integrated Search

1977-03-31

This is the Final Report of the "Tri-Level Study of the Causes of Traffic Accidents," performed by the Indiana University Institute for Research in Public Safety (IRPS), under contract to the National Highway Traffic Safety Administration (Contract N...

77 FR 12724 - International Postal Service-Global Expedited Package Services (GEPS) Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... POSTAL SERVICE\\TM\\ 39 CFR Part 20 International Postal Service--Global Expedited Package Services (GEPS) Contracts AGENCY: Postal Service TM . ACTION: Final rule. SUMMARY: The Postal Service will revise Mailing Standards of the United States Postal Service, International Mail Manual (IMM[supreg]) to...