Performance of MDockPP in CAPRI rounds 28-29 and 31-35 including the prediction of water-mediated interactions.

PubMed

Xu, Xianjin; Qiu, Liming; Yan, Chengfei; Ma, Zhiwei; Grinter, Sam Z; Zou, Xiaoqin

2017-03-01

Protein-protein interactions are either through direct contacts between two binding partners or mediated by structural waters. Both direct contacts and water-mediated interactions are crucial to the formation of a protein-protein complex. During the recent CAPRI rounds, a novel parallel searching strategy for predicting water-mediated interactions is introduced into our protein-protein docking method, MDockPP. Briefly, a FFT-based docking algorithm is employed in generating putative binding modes, and an iteratively derived statistical potential-based scoring function, ITScorePP, in conjunction with biological information is used to assess and rank the binding modes. Up to 10 binding modes are selected as the initial protein-protein complex structures for MD simulations in explicit solvent. Water molecules near the interface are clustered based on the snapshots extracted from independent equilibrated trajectories. Then, protein-ligand docking is employed for a parallel search for water molecules near the protein-protein interface. The water molecules generated by ligand docking and the clustered water molecules generated by MD simulations are merged, referred to as the predicted structural water molecules. Here, we report the performance of this protocol for CAPRI rounds 28-29 and 31-35 containing 20 valid docking targets and 11 scoring targets. In the docking experiments, we predicted correct binding modes for nine targets, including one high-accuracy, two medium-accuracy, and six acceptable predictions. Regarding the two targets for the prediction of water-mediated interactions, we achieved models ranked as "excellent" in accordance with the CAPRI evaluation criteria; one of these two targets is considered as a difficult target for structural water prediction. Proteins 2017; 85:424-434. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Template-based modeling and ab initio refinement of protein oligomer structures using GALAXY in CAPRI round 30.

PubMed

Lee, Hasup; Baek, Minkyung; Lee, Gyu Rie; Park, Sangwoo; Seok, Chaok

2017-03-01

Many proteins function as homo- or hetero-oligomers; therefore, attempts to understand and regulate protein functions require knowledge of protein oligomer structures. The number of available experimental protein structures is increasing, and oligomer structures can be predicted using the experimental structures of related proteins as templates. However, template-based models may have errors due to sequence differences between the target and template proteins, which can lead to functional differences. Such structural differences may be predicted by loop modeling of local regions or refinement of the overall structure. In CAPRI (Critical Assessment of PRotein Interactions) round 30, we used recently developed features of the GALAXY protein modeling package, including template-based structure prediction, loop modeling, model refinement, and protein-protein docking to predict protein complex structures from amino acid sequences. Out of the 25 CAPRI targets, medium and acceptable quality models were obtained for 14 and 1 target(s), respectively, for which proper oligomer or monomer templates could be detected. Symmetric interface loop modeling on oligomer model structures successfully improved model quality, while loop modeling on monomer model structures failed. Overall refinement of the predicted oligomer structures consistently improved the model quality, in particular in interface contacts. Proteins 2017; 85:399-407. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

New Additions to the ClusPro Server Motivated by CAPRI

PubMed Central

Vajda, Sandor; Yueh, Christine; Beglov, Dmitri; Bohnuud, Tanggis; Mottarella, Scott E.; Xia, Bing; Hall, David R.; Kozakov, Dima

2016-01-01

The heavily used protein-protein docking server ClusPro performs three computational steps as follows: (1) rigid body docking, (2) RMSD based clustering of the 1000 lowest energy structures, and (3) the removal of steric clashes by energy minimization. In response to challenges encountered in recent CAPRI targets, we added three new options to ClusPro. These are (1) accounting for Small Angle X-ray Scattering (SAXS) data in docking; (2) considering pairwise interaction data as restraints; and (3) enabling discrimination between biological and crystallographic dimers. In addition, we have developed an extremely fast docking algorithm based on 5D rotational manifold FFT, and an algorithm for docking flexible peptides that include known sequence motifs. We feel that these developments will further improve the utility of ClusPro. However, CAPRI emphasized several shortcomings of the current server, including the problem of selecting the right energy parameters among the five options provided, and the problem of selecting the best models among the 10 generated for each parameter set. In addition, results convinced us that further development is needed for docking homology models. Finally we discuss the difficulties we have encountered when attempting to develop a refinement algorithm that would be computationally efficient enough for inclusion in a heavily used server. PMID:27936493

Assessment of CAPRI predictions in rounds 3-5 shows progress in docking procedures.

PubMed

Méndez, Raúl; Leplae, Raphaël; Lensink, Marc F; Wodak, Shoshana J

2005-08-01

The current status of docking procedures for predicting protein-protein interactions starting from their three-dimensional (3D) structure is reassessed by evaluating blind predictions, performed during 2003-2004 as part of Rounds 3-5 of the community-wide experiment on Critical Assessment of PRedicted Interactions (CAPRI). Ten newly determined structures of protein-protein complexes were used as targets for these rounds. They comprised 2 enzyme-inhibitor complexes, 2 antigen-antibody complexes, 2 complexes involved in cellular signaling, 2 homo-oligomers, and a complex between 2 components of the bacterial cellulosome. For most targets, the predictors were given the experimental structures of 1 unbound and 1 bound component, with the latter in a random orientation. For some, the structure of the free component was derived from that of a related protein, requiring the use of homology modeling. In some of the targets, significant differences in conformation were displayed between the bound and unbound components, representing a major challenge for the docking procedures. For 1 target, predictions could not go to completion. In total, 1866 predictions submitted by 30 groups were evaluated. Over one-third of these groups applied completely novel docking algorithms and scoring functions, with several of them specifically addressing the challenge of dealing with side-chain and backbone flexibility. The quality of the predicted interactions was evaluated by comparison to the experimental structures of the targets, made available for the evaluation, using the well-agreed-upon criteria used previously. Twenty-four groups, which for the first time included an automatic Web server, produced predictions ranking from acceptable to highly accurate for all targets, including those where the structures of the bound and unbound forms differed substantially. These results and a brief survey of the methods used by participants of CAPRI Rounds 3-5 suggest that genuine progress in the performance of docking methods is being achieved, with CAPRI acting as the catalyst.

SU-F-T-25: Design and Implementation of a Multi-Purpose Applicator for Pelvic Brachytherapy Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bogue, J; Parsai, E

Purpose: The current generation of inflatable multichannel brachytherapy applicators, such as the Varian Capri, have limited implementation to only vaginal and rectal cancers. While there are similar designs utilizing rigid, non-inflatable applicators, these alternatives could cause increased dose to surrounding tissue due to air gaps. Modification of the Capri could allow for easier treatment planning by reducing the number of channels and increased versatility by modifying the applicator to include an attachable single tandem for cervical or multiple tandems for endometrial applications. Methods: A Varian Capri applicator was simulated in water to replicate a patient. Multiple plans were optimized tomore » deliver a prescribed dose of 100 cGy at 5mm away from the exterior of the applicator using six to thirteen existing channels. The current model was expanded upon to include a detachable tandem or multiple tandoms to increase its functionality to both cervical and endometrial cancers. Models were constructed in both threedimensional rendering software and Monte Carlo to allow prototyping and simulations. Results: Treatment plans utilizing six to thirteen channels produced limited dosimetric differences between channel arrangements, with a seven channel plan very closely approximating the thirteen channels. It was concluded that only seven channels would be necessary in future simulations to give an accurate representation of the applicator. Tandem attachments were prototyped for the applicator to demonstrate the ease of which they could be included. Future simulation in treatment planning software and Monte Carlo results will be presented to further define the ideal applicator geometry Conclusion: The current Capri applicator design could be easily modified to increase applicability to include cervical and endometrial treatments in addition to vaginal and rectal cancers. This new design helps in a more versatile single use applicator that can easily be inserted and to further reduce dose to critical structures during brachytherapy treatments.« less

Redescription of poorly known species of Ceratothoa Dana, 1852 (Crustacea, Isopoda, Cymothoidae), based on original type material

PubMed Central

Hadfield, Kerry A.; Bruce, Niel L.; Smit, Nico J.

2016-01-01

Abstract Due to the difficulty in accurately identifying cymothoids, these parasitic isopods are often incorrectly named or confused with other species. Within the genus Ceratothoa, a number of recent studies have aimed at clarifying some of the problematic species; however, several of the less studied species still require revision. This paper redescribes, from type material, several poorly known Ceratothoa species including Ceratothoa angulata, Ceratothoa capri, Ceratothoa carinata, Ceratothoa collaris, Ceratothoa gilberti, Ceratothoa gobii, Ceratothoa guttata, Ceratothoa italica, Ceratothoa oestroides, and Ceratothoa verrucosa, further resolving taxonomic uncertainties within the genus. PMID:27408544

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrell, John T

This is the keynote presentation on the Co-Optimization of Fuels and Engines (Co-Optima) Initiative delivered at SAE International's ICE 2017 - 13th International Conference on Engines & Vehicles held in Capri, Italy.

New additions to the ClusPro server motivated by CAPRI.

PubMed

Vajda, Sandor; Yueh, Christine; Beglov, Dmitri; Bohnuud, Tanggis; Mottarella, Scott E; Xia, Bing; Hall, David R; Kozakov, Dima

2017-03-01

The heavily used protein-protein docking server ClusPro performs three computational steps as follows: (1) rigid body docking, (2) RMSD based clustering of the 1000 lowest energy structures, and (3) the removal of steric clashes by energy minimization. In response to challenges encountered in recent CAPRI targets, we added three new options to ClusPro. These are (1) accounting for small angle X-ray scattering data in docking; (2) considering pairwise interaction data as restraints; and (3) enabling discrimination between biological and crystallographic dimers. In addition, we have developed an extremely fast docking algorithm based on 5D rotational manifold FFT, and an algorithm for docking flexible peptides that include known sequence motifs. We feel that these developments will further improve the utility of ClusPro. However, CAPRI emphasized several shortcomings of the current server, including the problem of selecting the right energy parameters among the five options provided, and the problem of selecting the best models among the 10 generated for each parameter set. In addition, results convinced us that further development is needed for docking homology models. Finally, we discuss the difficulties we have encountered when attempting to develop a refinement algorithm that would be computationally efficient enough for inclusion in a heavily used server. Proteins 2017; 85:435-444. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

VARTM Variability and Substantiation

DOT National Transportation Integrated Search

2008-06-18

Presentation overview: establish the fundamental understanding of the various VARTM processes; Flow model is fully developed for SCRIMP, VAP, and CAPRI process; Compaction behavior has been evaluated for all processes; Dry compaction during debulking...

First clinical implementation of the Capri applicator

PubMed Central

2014-01-01

This study was to assess the Capri applicator for patients with endometrial cancer undergoing high‐radiation dose treatments following external‐beam radiation therapy. The Capri applicator is an inflatable vaginal cylinder with multiple channels. It is used to tailor the dose distribution to an asymmetric vaginal disease, and better spare organs at risk. Five patients with high‐risk endometrial cancer were selected for this study. The patients were treated with a high dose of radiation using the Capri applicator: daily fraction of 7 Gy was prescribed for a total dose of 21 Gy. The treatment plans included radiobiological parameters such as equivalent uniform dose (EUD), normal tissue complication probability (NTCP), and tumor control probability (TCP). Based on the dose‐volume histograms (DVH), we also calculated four quality factors: conformity index (CI), dose homogeneity index (DHI), dose nonuniformity index (DNR), and overdose index (OI). The TCP values range from 82.26% to 95.92%. Very low values of NTCP were observed for the bladder and rectum. The EUDs to organs at risk ranged from 4.65 Gy to 18.22 Gy for the bladder, and from 3.41 Gy from to 6.56 Gy for the rectum. The mean CI was 1.05(SD=0.0008). The mean DNR was 0.10(range0.0−0.295,SD=0.100). The mean OI was 0.019(SD=0.028). The DHIs were in the range of 1.0−0.754(mean0.886,SD=0.116). The use of a multichannel vaginal cylinder may not only help cover extensive vaginal disease, but also reduce the dose to the rectum. This dosimetric analysis shows that rectal doses could be reduced using a multichannel cylinder. However, the dose delivered to the bladder based on EUD calculation may be higher than that obtained with other methods. Each patient must be evaluated independently to determine if a multichannel treatment is appropriate. Clinical followup will show whether this rectal dose sparing translates into a real toxicity improvement. PACS number: 3.6.96.0 PMID:24423857

Impact of Proton Pump Inhibitor Therapy on the Efficacy of Clopidogrel in the CAPRIE and CREDO Trials

PubMed Central

Dunn, Steven P.; Steinhubl, Steven R.; Bauer, Deborah; Charnigo, Richard J.; Berger, Peter B.; Topol, Eric J.

2013-01-01

Background Proton pump inhibitors (PPIs) may interfere with the metabolic activation of clopidogrel via inhibition of cytochrome P450 2C19, but the clinical implications remain unclear. Methods and Results The impact of PPI use on the 1‐year primary end point (ischemic stroke, myocardial infarction [MI], or vascular death) in the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial and the 28‐day (all‐cause death, MI, or urgent target vessel revascularization) and 1‐year (all‐cause death, MI, or stroke) primary end points in the Clopidogrel for Reduction of Events During Observation (CREDO) trial were examined. Clopidogrel appeared to elevate risk for the primary end point in CAPRIE among PPI users (estimated hazard ratio [EHR] 2.66, 95% CI 0.94 to 7.50) while lowering it for non‐PPI users (EHR 0.90, 95% CI 0.83 to 0.99, interaction P=0.047). Moreover, PPI use was associated with worse outcomes in patients receiving clopidogrel (EHR 2.39, 95% CI 1.74 to 3.28) but not aspirin (EHR 1.04, 95% CI 0.70 to 1.57, interaction P=0.001). Clopidogrel did not significantly alter risk for the 1‐year primary end point in CREDO among PPI users (EHR 0.82, 95% CI 0.48 to 1.40) while lowering it for non‐PPI users (EHR 0.71, 95% CI 0.52 to 0.98, interaction P=0.682). Also, PPI use was associated with worse outcomes in both patients receiving clopidogrel (EHR 1.67, 95% CI 1.06 to 2.64) and those receiving placebo (EHR 1.56, 95% CI 1.06 to 2.30, interaction P=0.811). Conclusions In CREDO, the efficacy of clopidogrel was not significantly affected by PPI use. However, in CAPRIE, clopidogrel was beneficial to non‐PPI users while apparently harmful to PPI users. Whether this negative interaction is clinically important for patients receiving clopidogrel without aspirin needs further study. PMID:23525436

Using the Concept of Transient Complex for Affinity Predictions in CAPRI Rounds 20–27 and Beyond

PubMed Central

Qin, Sanbo; Zhou, Huan-Xiang

2013-01-01

Predictions of protein-protein binders and binding affinities have traditionally focused on features pertaining to the native complexes. In developing a computational method for predicting protein-protein association rate constants, we introduced the concept of transient complex after mapping the interaction energy surface. The transient complex is located at the outer boundary of the bound-state energy well, having near-native separation and relative orientation between the subunits but not yet formed most of the short-range native interactions. We found that the width of the binding funnel and the electrostatic interaction energy of the transient complex are among the features predictive of binders and binding affinities. These ideas were very promising for the five affinity-related targets (T43–45, 55, and 56) of CAPRI rounds 20–27. For T43, we ranked the single crystallographic complex as number 1 and were one of only two groups that clearly identified that complex as a true binder; for T44, we ranked the only design with measurable binding affinity as number 4. For the nine docking targets, continuing on our success in previous CAPRI rounds, we produced 10 medium-quality models for T47 and acceptable models for T48 and T49. We conclude that the interaction energy landscape and the transient complex in particular will complement existing features in leading to better prediction of binding affinities. PMID:23873496

Optimization of pyDock for the new CAPRI challenges: Docking of homology-based models, domain-domain assembly and protein-RNA binding.

PubMed

Pons, Carles; Solernou, Albert; Perez-Cano, Laura; Grosdidier, Solène; Fernandez-Recio, Juan

2010-11-15

We describe here our results in the last CAPRI edition. We have participated in all targets, both as predictors and as scorers, using our pyDock docking methodology. The new challenges (homology-based modeling of the interacting subunits, domain-domain assembling, and protein-RNA interactions) have pushed our computer tools to the limits and have encouraged us to devise new docking approaches. Overall, the results have been quite successful, in line with previous editions, especially considering the high difficulty of some of the targets. Our docking approaches succeeded in five targets as predictors or as scorers (T29, T34, T35, T41, and T42). Moreover, with the inclusion of available information on the residues expected to be involved in the interaction, our protocol would have also succeeded in two additional cases (T32 and T40). In the remaining targets (except T37), results were equally poor for most of the groups. We submitted the best model (in ligand RMSD) among scorers for the unbound-bound target T29, the second best model among scorers for the protein-RNA target T34, and the only correct model among predictors for the domain assembly target T35. In summary, our excellent results for the new proposed challenges in this CAPRI edition showed the limitations and applicability of our approaches and encouraged us to continue developing methodologies for automated biomolecular docking. © 2010 Wiley-Liss, Inc.

Lessons from (co-)evolution in the docking of proteins and peptides for CAPRI Rounds 28-35.

PubMed

Yu, Jinchao; Andreani, Jessica; Ochsenbein, Françoise; Guerois, Raphaël

2017-03-01

Computational protein-protein docking is of great importance for understanding protein interactions at the structural level. Critical assessment of prediction of interactions (CAPRI) experiments provide the protein docking community with a unique opportunity to blindly test methods based on real-life cases and help accelerate methodology development. For CAPRI Rounds 28-35, we used an automatic docking pipeline integrating the coarse-grained co-evolution-based potential InterEvScore. This score was developed to exploit the information contained in the multiple sequence alignments of binding partners and selectively recognize co-evolved interfaces. Together with Zdock/Frodock for rigid-body docking, SOAP-PP for atomic potential and Rosetta applications for structural refinement, this pipeline reached high performance on a majority of targets. For protein-peptide docking and interfacial water position predictions, we also explored different means of taking evolutionary information into account. Overall, our group ranked 1 st by correctly predicting 10 targets, composed of 1 High, 7 Medium and 2 Acceptable predictions. Excellent and Outstanding levels of accuracy were reached for each of the two water prediction targets, respectively. Altogether, in 15 out of 18 targets in total, evolutionary information, either through co-evolution or conservation analyses, could provide key constraints to guide modeling towards the most likely assemblies. These results open promising perspectives regarding the way evolutionary information can be valuable to improve docking prediction accuracy. Proteins 2017; 85:378-390. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Evaluation of protein docking predictions using Hex 3.1 in CAPRI rounds 1 and 2.

PubMed

Ritchie, David W

2003-07-01

This article describes and reviews our efforts using Hex 3.1 to predict the docking modes of the seven target protein-protein complexes presented in the CAPRI (Critical Assessment of Predicted Interactions) blind docking trial. For each target, the structure of at least one of the docking partners was given in its unbound form, and several of the targets involved large multimeric structures (e.g., Lactobacillus HPr kinase, hemagglutinin, bovine rotavirus VP6). Here we describe several enhancements to our original spherical polar Fourier docking correlation algorithm. For example, a novel surface sphere smothering algorithm is introduced to generate multiple local coordinate systems around the surface of a large receptor molecule, which may be used to define a small number of initial ligand-docking orientations distributed over the receptor surface. High-resolution spherical polar docking correlations are performed over the resulting receptor surface patches, and candidate docking solutions are refined by using a novel soft molecular mechanics energy minimization procedure. Overall, this approach identified two good solutions at rank 5 or less for two of the seven CAPRI complexes. Subsequent analysis of our results shows that Hex 3.1 is able to place good solutions within a list of

Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility.

PubMed

Schueler-Furman, Ora; Wang, Chu; Baker, David

2005-08-01

RosettaDock uses real-space Monte Carlo minimization (MCM) on both rigid-body and side-chain degrees of freedom to identify the lowest free energy docked arrangement of 2 protein structures. An improved version of the method that uses gradient-based minimization for off-rotamer side-chain optimization and includes information from unbound structures was used to create predictions for Rounds 4 and 5 of CAPRI. First, large numbers of independent MCM trajectories were carried out and the lowest free energy docked configurations identified. Second, new trajectories were started from these lowest energy structures to thoroughly sample the surrounding conformation space, and the lowest energy configurations were submitted as predictions. For all cases in which there were no significant backbone conformational changes, a small number of very low-energy configurations were identified in the first, global search and subsequently found to be close to the center of the basin of attraction in the free energy landscape in the second, local search. Following the release of the experimental coordinates, it was found that the centers of these free energy minima were remarkably close to the native structures in not only the rigid-body orientation but also the detailed conformations of the side-chains. Out of 8 targets, the lowest energy models had interface root-mean-square deviations (RMSDs) less than 1.1 A from the correct structures for 6 targets, and interface RMSDs less than 0.4 A for 3 targets. The predictions were top submissions to CAPRI for Targets 11, 12, 14, 15, and 19. The close correspondence of the lowest free energy structures found in our searches to the experimental structures suggests that our free energy function is a reasonable representation of the physical chemistry, and that the real space search with full side-chain flexibility to some extent solves the protein-protein docking problem in the absence of significant backbone conformational changes. On the other hand, the approach fails when there are significant backbone conformational changes as the steric complementarity of the 2 proteins cannot be modeled without incorporating backbone flexibility, and this is the major goal of our current work.

Using a consensus approach based on the conservation of inter-residue contacts to rank CAPRI models.

PubMed

Vangone, Anna; Cavallo, Luigi; Oliva, Romina

2013-12-01

Herein we propose the use of a consensus approach, CONSRANK, for ranking CAPRI models. CONSRANK relies on the conservation of inter-residue contacts in the analyzed decoys ensemble. Models are ranked according to their ability to match the most frequently observed contacts. We applied CONSRANK to 19 CAPRI protein-protein targets, covering a wide range of prediction difficulty and involved in a variety of biological functions. CONSRANK results are consistently good, both in terms of native-like (NL) solutions ranked in the top positions and of values of the Area Under the receiver operating characteristic Curve (AUC). For targets having a percentage of NL solutions above 3%, an excellent performance is found, with AUC values approaching 1. For the difficult target T46, having only 3.4% NL solutions, the number of NL solutions in the top 5 and 10 ranked positions is enriched by a factor 30, and the AUC value is as high as 0.997. AUC values below 0.8 are only found for targets featuring a percentage of NL solutions within 1.1%. Remarkably, a false consensus emerges only in one case, T42, which happens to be an artificial protein, whose assembly details remain uncertain, based on controversial experimental data. We also show that CONSRANK still performs very well on a limited number of models, provided that more than 1 NL solution is included in the ensemble, thus extending its applicability to cases where few dozens of models are available. Copyright © 2013 Wiley Periodicals, Inc.

Modeling side-chains using molecular dynamics improve recognition of binding region in CAPRI targets.

PubMed

Camacho, Carlos J

2005-08-01

The CAPRI-II experiment added an extra level of complexity to the problem of predicting protein-protein interactions by including 5 targets for which participants had to build or complete the 3-dimensional (3D) structure of either the receptor or ligand based on the structure of a close homolog. In this article, we describe how modeling key side-chains using molecular dynamics (MD) in explicit solvent improved the recognition of the binding region of a free energy- based computational docking method. In particular, we show that MD is able to predict with relatively high accuracy the rotamer conformation of the anchor side-chains important for molecular recognition as suggested by Rajamani et al. (Proc Natl Acad Sci USA 2004;101:11287-11292). As expected, the conformations are some of the most common rotamers for the given residue, while latch side-chains that undergo induced fit upon binding are forced into less common conformations. Using these models as starting conformations in conjunction with the rigid-body docking server ClusPro and the flexible docking algorithm SmoothDock, we produced valuable predictions for 6 of the 9 targets in CAPRI-II, missing only the 3 targets that underwent significant structural rearrangements upon binding. We also show that our free energy- based scoring function, consisting of the sum of van der Waals, Coulombic electrostatic with a distance-dependent dielectric, and desolvation free energy successfully discriminates the nativelike conformation of our submitted predictions. The latter emphasizes the critical role that thermodynamics plays on our methodology, and validates the generality of the algorithm to predict protein interactions.

Human and Server Docking Prediction for CAPRI Round 30–35 Using LZerD with Combined Scoring Functions

PubMed Central

Peterson, Lenna X.; Kim, Hyungrae; Esquivel-Rodriguez, Juan; Roy, Amitava; Han, Xusi; Shin, Woong-Hee; Zhang, Jian; Terashi, Genki; Lee, Matt; Kihara, Daisuke

2016-01-01

We report the performance of protein-protein docking predictions by our group for recent rounds of the Critical Assessment of Prediction of Interactions (CAPRI), a community-wide assessment of state-of-the-art docking methods. Our prediction procedure uses a protein-protein docking program named LZerD developed in our group. LZerD represents a protein surface with 3D Zernike descriptors (3DZD), which are based on a mathematical series expansion of a 3D function. The appropriate soft representation of protein surface with 3DZD makes the method more tolerant to conformational change of proteins upon docking, which adds an advantage for unbound docking. Docking was guided by interface residue prediction performed with BindML and cons-PPISP as well as literature information when available. The generated docking models were ranked by a combination of scoring functions, including PRESCO, which evaluates the native-likeness of residues’ spatial environments in structure models. First, we discuss the overall performance of our group in the CAPRI prediction rounds and investigate the reasons for unsuccessful cases. Then, we examine the performance of several knowledge-based scoring functions and their combinations for ranking docking models. It was found that the quality of a pool of docking models generated by LZerD, i.e. whether or not the pool includes near-native models, can be predicted by the correlation of multiple scores. Although the current analysis used docking models generated by LZerD, findings on scoring functions are expected to be universally applicable to other docking methods. PMID:27654025

Addressing recent docking challenges: A hybrid strategy to integrate template-based and free protein-protein docking.

PubMed

Yan, Yumeng; Wen, Zeyu; Wang, Xinxiang; Huang, Sheng-You

2017-03-01

Protein-protein docking is an important computational tool for predicting protein-protein interactions. With the rapid development of proteomics projects, more and more experimental binding information ranging from mutagenesis data to three-dimensional structures of protein complexes are becoming available. Therefore, how to appropriately incorporate the biological information into traditional ab initio docking has been an important issue and challenge in the field of protein-protein docking. To address these challenges, we have developed a Hybrid DOCKing protocol of template-based and template-free approaches, referred to as HDOCK. The basic procedure of HDOCK is to model the structures of individual components based on the template complex by a template-based method if a template is available; otherwise, the component structures will be modeled based on monomer proteins by regular homology modeling. Then, the complex structure of the component models is predicted by traditional protein-protein docking. With the HDOCK protocol, we have participated in the CPARI experiment for rounds 28-35. Out of the 25 CASP-CAPRI targets for oligomer modeling, our HDOCK protocol predicted correct models for 16 targets, ranking one of the top algorithms in this challenge. Our docking method also made correct predictions on other CAPRI challenges such as protein-peptide binding for 6 out of 8 targets and water predictions for 2 out of 2 targets. The advantage of our hybrid docking approach over pure template-based docking was further confirmed by a comparative evaluation on 20 CASP-CAPRI targets. Proteins 2017; 85:497-512. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Sense and simplicity in HADDOCK scoring: Lessons from CASP‐CAPRI round 1

PubMed Central

Vangone, A.; Rodrigues, J. P. G. L. M.; Xue, L. C.; van Zundert, G. C. P.; Geng, C.; Kurkcuoglu, Z.; Nellen, M.; Narasimhan, S.; Karaca, E.; van Dijk, M.; Melquiond, A. S. J.; Visscher, K. M.; Trellet, M.; Kastritis, P. L.

2016-01-01

ABSTRACT Our information‐driven docking approach HADDOCK is a consistent top predictor and scorer since the start of its participation in the CAPRI community‐wide experiment. This sustained performance is due, in part, to its ability to integrate experimental data and/or bioinformatics information into the modelling process, and also to the overall robustness of the scoring function used to assess and rank the predictions. In the CASP‐CAPRI Round 1 scoring experiment we successfully selected acceptable/medium quality models for 18/14 of the 25 targets – a top‐ranking performance among all scorers. Considering that for only 20 targets acceptable models were generated by the community, our effective success rate reaches as high as 90% (18/20). This was achieved using the standard HADDOCK scoring function, which, thirteen years after its original publication, still consists of a simple linear combination of intermolecular van der Waals and Coulomb electrostatics energies and an empirically derived desolvation energy term. Despite its simplicity, this scoring function makes sense from a physico‐chemical perspective, encoding key aspects of biomolecular recognition. In addition to its success in the scoring experiment, the HADDOCK server takes the first place in the server prediction category, with 16 successful predictions. Much like our scoring protocol, because of the limited time per target, the predictions relied mainly on either an ab initio center‐of‐mass and symmetry restrained protocol, or on a template‐based approach whenever applicable. These results underline the success of our simple but sensible prediction and scoring scheme. Proteins 2017; 85:417–423. © 2016 Wiley Periodicals, Inc. PMID:27802573

Morphology and geology of the ILD in Capri/Eos Chasma (Mars) from visible and infrared data

NASA Astrophysics Data System (ADS)

Flahaut, Jessica; Quantin, Cathy; Allemand, Pascal; Thomas, Pierre

2010-05-01

Layered deposits have been observed in different locations at the surface of Mars, as crater floors and canyons systems. Their high interest relies in the fact they imply dynamical conditions in their deposition medium. Indeed, in opposition to most of the rocks of the martian surface, which have a volcanic origin, bright layered deposits seems to be sedimentary outcrops. Capri Chasma, a canyon located at the outlet of Valles Marineris, exhibits such deposits called Interior Layered Deposits (ILD). A large array of visible and infrared spacecraft data were used to build a Geographic Information System (GIS). We added HiRiSE images, from the recent MRO mission, which offer a spatial resolution of 25 cm per pixel. It allowed the mapping and the analysis of morphologies in the canyon. We highlighted that the ILD are several kilometers thick and flat-top stratified deposits. They overlap the chaotic floor. They are surrounded and cut by several flow features that imply that liquid water was still acting after the formation of these stratified deposits. The density of crater on the floor of Capri Chasma was quantified. The current topography was aged to 3 Gyr. All these morphological information allow us to suggest a plausible geological history for Capri Chasma. We propose that the Interior Layered Deposits have formed during the Hesperian, during or after the opening of the canyon. Some observations argue that water discharges have happened at several times before and just after the formation of the ILD. Liquid water must have played a major role in the formation of these deposits after 3.5 Gyr, implying that it was present in surface at least locally and temporarily. If this can be applied to ILD in others canyons of Valles Marineris, it would imply that liquid water was stable in surface or sub-surface during the Hesperian. Or in the actual conditions, with a cold and dry martian surface, long-term standing water bodies are not possible. Thus we suggest that either the climate at the Hesperian was cold, but wetter, or as warm as the Noachian climate, what is less likely. Nevertheless, the global climate change which has occurred at the beginning of Mars history may have been later than announced.

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-09-22

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located on the eastern side of Coprates Chasma, near Capri Chasma. The image shows multiple landslide features, which form lobed shaped deposits at the bottom of the canyon cliff face. Sand dunes are visible both on the landslide deposit and other parts of the canyon floor. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 16628 Latitude: -15.4094 Longitude: 304.726 Instrument: VIS Captured: 2005-09-13 10:38 https://photojournal.jpl.nasa.gov/catalog/PIA21990

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-09-26

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located on the eastern side of Coprates Chasma, near Capri Chasma. The image shows multiple landslide features, which form lobed shaped deposits at the bottom of the canyon cliff face. Sand dunes are visible both on the landslide deposit and other parts of the canyon floor. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 16653 Latitude: -14.2759 Longitude: 303.707 Instrument: VIS Captured: 2005-09-15 12:01 https://photojournal.jpl.nasa.gov/catalog/PIA21991

Human and server docking prediction for CAPRI round 30-35 using LZerD with combined scoring functions.

PubMed

Peterson, Lenna X; Kim, Hyungrae; Esquivel-Rodriguez, Juan; Roy, Amitava; Han, Xusi; Shin, Woong-Hee; Zhang, Jian; Terashi, Genki; Lee, Matt; Kihara, Daisuke

2017-03-01

We report the performance of protein-protein docking predictions by our group for recent rounds of the Critical Assessment of Prediction of Interactions (CAPRI), a community-wide assessment of state-of-the-art docking methods. Our prediction procedure uses a protein-protein docking program named LZerD developed in our group. LZerD represents a protein surface with 3D Zernike descriptors (3DZD), which are based on a mathematical series expansion of a 3D function. The appropriate soft representation of protein surface with 3DZD makes the method more tolerant to conformational change of proteins upon docking, which adds an advantage for unbound docking. Docking was guided by interface residue prediction performed with BindML and cons-PPISP as well as literature information when available. The generated docking models were ranked by a combination of scoring functions, including PRESCO, which evaluates the native-likeness of residues' spatial environments in structure models. First, we discuss the overall performance of our group in the CAPRI prediction rounds and investigate the reasons for unsuccessful cases. Then, we examine the performance of several knowledge-based scoring functions and their combinations for ranking docking models. It was found that the quality of a pool of docking models generated by LZerD, that is whether or not the pool includes near-native models, can be predicted by the correlation of multiple scores. Although the current analysis used docking models generated by LZerD, findings on scoring functions are expected to be universally applicable to other docking methods. Proteins 2017; 85:513-527. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

SYMPOSIUM IN ITALY: FISH PHYSIOLOGY, TOXICOLOGY, AND WATER QUALITY

EPA Science Inventory

Scientists from Europe, North America and South America convened in Capri, Italy, April 24-28, 2006 for the Ninth International Symposium on Fish Physiology, Toxicology, and Water Quality. The subject of the meeting was Eutrophication: The toxic effects of ammonia, nitrite and th...

(Proceedings) 18th Advanced ICFA Beam Dynamics Workshop on Quantum Aspects of Beam Physics (QABP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Pisin

2002-10-25

The 18th Advanced ICFA Beam Dynamics Workshop on ''Quantum Aspects of Beam Physics'' was held from October 15 to 20, 2000, in Capri, Italy. This was the second workshop under the same title. The first one was held in Monterey, California, in January, 1998. Following the footstep of the first meeting, the second one in Capri was again a tremendous success, both scientifically and socially. About 70 colleagues from astrophysics, atomic physics, beam physics, condensed matter physics, particle physics, and general relativity gathered to update and further explore the topics covered in the Monterey workshop. Namely, the following topics weremore » actively discussed: (1) Quantum Fluctuations in Beam Dynamics; (2) Photon-Electron Interaction in Beam handling; (3) Physics of Condensed Beams; (4) Beam Phenomena under Strong Fields; (5) Quantum Methodologies in Beam Physics. In addition, there was a newly introduced subject on Astro-Beam Physics and Laboratory Astrophysics.« less

Ca-Pri a Cellular Automata Phenomenological Research Investigation: Simulation Results

NASA Astrophysics Data System (ADS)

Iannone, G.; Troisi, A.

2013-05-01

Following the introduction of a phenomenological cellular automata (CA) model capable to reproduce city growth and urban sprawl, we develop a toy model simulation considering a realistic framework. The main characteristic of our approach is an evolution algorithm based on inhabitants preferences. The control of grown cells is obtained by means of suitable functions which depend on the initial condition of the simulation. New born urban settlements are achieved by means of a logistic evolution of the urban pattern while urban sprawl is controlled by means of the population evolution function. In order to compare model results with a realistic urban framework we have considered, as the area of study, the island of Capri (Italy) in the Mediterranean Sea. Two different phases of the urban evolution on the island have been taken into account: a new born initial growth as induced by geographic suitability and the simulation of urban spread after 1943 induced by the population evolution after this date.

Protein-protein docking with binding site patch prediction and network-based terms enhanced combinatorial scoring.

PubMed

Gong, Xinqi; Wang, Panwen; Yang, Feng; Chang, Shan; Liu, Bin; He, Hongqiu; Cao, Libin; Xu, Xianjin; Li, Chunhua; Chen, Weizu; Wang, Cunxin

2010-11-15

Protein-protein docking has made much progress in recent years, but challenges still exist. Here we present the application of our docking approach HoDock in CAPRI. In this approach, a binding site prediction is implemented to reduce docking sampling space and filter out unreasonable docked structures, and a network-based enhanced combinatorial scoring function HPNCscore is used to evaluate the decoys. The experimental information was combined with the predicted binding site to pick out the most likely key binding site residues. We applied the HoDock method in the recent rounds of the CAPRI experiments, and got good results as predictors on targets 39, 40, and 41. We also got good results as scorers on targets 35, 37, 40, and 41. This indicates that our docking approach can contribute to the progress of protein-protein docking methods and to the understanding of the mechanism of protein-protein interactions. © 2010 Wiley-Liss, Inc.

The Five Shifts: Ensuring an Environment for Healing

ERIC Educational Resources Information Center

Longhurst, James E.; Brown, Juanita Capri

2013-01-01

James E. Longhurst and Juanita Capri Brown introduce us to the Five habits of mind practiced in the Glasswing Healing Racism, program, which is designed to foster personal transformation, interpersonal understanding, and racial equity. Longhurst and Brown note that the topic of racism is not typically brought up in mixed company. It can elicit a…

General discussion on g-2

NASA Astrophysics Data System (ADS)

Knecht, Marc

2018-05-01

Progress made on the theoretical aspects of the standard model contributions to the anomalous magnetic moment of the charged leptons since the first FCCP Workshop on Capri in 2015 is reviewed. Emphasis is in particular given to the various cross-checks that have already become available, or might become available in the future, for several important contributions.

The Plains are Not Plain

NASA Image and Video Library

2016-06-01

This image from NASA Mars Reconnaissance Orbiter spacecraft covers some of the plains south of Capri Chasma in eastern Valles Marineris. Where the aeolian (wind-blown) sedimentary cover has been stripped away, we see diverse colors indicative of of a variety of altered minerals formed in Mars' wetter past. http://photojournal.jpl.nasa.gov/catalog/PIA20730

A database for reproducible manipulation research: CapriDB - Capture, Print, Innovate.

PubMed

Pokorny, Florian T; Bekiroglu, Yasemin; Pauwels, Karl; Butepage, Judith; Scherer, Clara; Kragic, Danica

2017-04-01

We present a novel approach and database which combines the inexpensive generation of 3D object models via monocular or RGB-D camera images with 3D printing and a state of the art object tracking algorithm. Unlike recent efforts towards the creation of 3D object databases for robotics, our approach does not require expensive and controlled 3D scanning setups and aims to enable anyone with a camera to scan, print and track complex objects for manipulation research. The proposed approach results in detailed textured mesh models whose 3D printed replicas provide close approximations of the originals. A key motivation for utilizing 3D printed objects is the ability to precisely control and vary object properties such as the size, material properties and mass distribution in the 3D printing process to obtain reproducible conditions for robotic manipulation research. We present CapriDB - an extensible database resulting from this approach containing initially 40 textured and 3D printable mesh models together with tracking features to facilitate the adoption of the proposed approach.

Quotable physics

NASA Astrophysics Data System (ADS)

Chomet, Seweryn

2008-03-01

Anton Capri is an alumnus of Princeton University, where he specialized in quantum field theory, and, since 1998, has been a distinguished professor emeritus at the University of Alberta in Canada. Since his nominal retirement he has devoted much of his time to writing and has now published, among other things, two linked books that present a variety of anecdotes involving famous physicists, as well as useful biographical sketches of them. The origin of these books is clearly defined by their author. "I have not any pretensions to having produced a 'scholarly' work," he writes. "Some of the stories recorded here are gossip, or physics folklore. I have tried to verify as many of the stories as I could, but I have not hesitated to include all stories that I heard and noted down."

Computer-aided Human Centric Cyber Situation Awareness

DTIC Science & Technology

2016-03-20

in Video, IJCAI: International Joint Conf. on Artificial Intelligence . 16-JUL-11, . : , Kun Sun, Sushil Jajodia, Jason Li, Yi Cheng, Wei Tang...Cyber-Security Conference, June 2015. 2. V.S. Subrahmanian, Invited Speaker, Summer School on Business Intelligence and Big Data Analysis, Capri, Italy... Cybersecurity Conference, Yuval Ne’eman Workshop for Science, Technology and Security, Tel Aviv University, the Israeli National Cyber Bureau, Prime

Aerodynamic Design of Complex Configurations Using Cartesian Methods and CAD Geometry

NASA Technical Reports Server (NTRS)

Nemec, Marian; Aftosmis, Michael J.; Pulliam, Thomas H.

2003-01-01

The objective for this paper is to present the development of an optimization capability for the Cartesian inviscid-flow analysis package of Aftosmis et al. We evaluate and characterize the following modules within the new optimization framework: (1) A component-based geometry parameterization approach using a CAD solid representation and the CAPRI interface. (2) The use of Cartesian methods in the development Optimization techniques using a genetic algorithm. The discussion and investigations focus on several real world problems of the optimization process. We examine the architectural issues associated with the deployment of a CAD-based design approach in a heterogeneous parallel computing environment that contains both CAD workstations and dedicated compute nodes. In addition, we study the influence of noise on the performance of optimization techniques, and the overall efficiency of the optimization process for aerodynamic design of complex three-dimensional configurations. of automated optimization tools. rithm and a gradient-based algorithm.

Docking and scoring protein complexes: CAPRI 3rd Edition.

PubMed

Lensink, Marc F; Méndez, Raúl; Wodak, Shoshana J

2007-12-01

The performance of methods for predicting protein-protein interactions at the atomic scale is assessed by evaluating blind predictions performed during 2005-2007 as part of Rounds 6-12 of the community-wide experiment on Critical Assessment of PRedicted Interactions (CAPRI). These Rounds also included a new scoring experiment, where a larger set of models contributed by the predictors was made available to groups developing scoring functions. These groups scored the uploaded set and submitted their own best models for assessment. The structures of nine protein complexes including one homodimer were used as targets. These targets represent biologically relevant interactions involved in gene expression, signal transduction, RNA, or protein processing and membrane maintenance. For all the targets except one, predictions started from the experimentally determined structures of the free (unbound) components or from models derived by homology, making it mandatory for docking methods to model the conformational changes that often accompany association. In total, 63 groups and eight automatic servers, a substantial increase from previous years, submitted docking predictions, of which 1994 were evaluated here. Fifteen groups submitted 305 models for five targets in the scoring experiment. Assessment of the predictions reveals that 31 different groups produced models of acceptable and medium accuracy-but only one high accuracy submission-for all the targets, except the homodimer. In the latter, none of the docking procedures reproduced the large conformational adjustment required for correct assembly, underscoring yet again that handling protein flexibility remains a major challenge. In the scoring experiment, a large fraction of the groups attained the set goal of singling out the correct association modes from incorrect solutions in the limited ensembles of contributed models. But in general they seemed unable to identify the best models, indicating that current scoring methods are probably not sensitive enough. With the increased focus on protein assemblies, in particular by structural genomics efforts, the growing community of CAPRI predictors is engaged more actively than ever in the development of better scoring functions and means of modeling conformational flexibility, which hold promise for much progress in the future. (c) 2007 Wiley-Liss, Inc.

Bernardino Ramazzini: the father of occupational medicine.

PubMed

Pope, Malcolm H

2004-10-15

Bernardino Ramazzini was born on October 4, 1633, in the small town of Capri located in the duchy of Modula, Italy. He is credited with establishing the field of occupational medicine during his lifetime. His major contributions came after 1682, when Duke Francesco II of Modena assigned him to establish a medical department at the University of Modena. He was installed in the title of professor "Medicinae Theoricae." In 1700, Ramazzini was appointed chair of practical medicine in Padua, Republic of Venice, the premier medical faculty in Italy. In 1700, he wrote the seminal book on occupational diseases and industrial hygiene, De Morbis Artificum Diatriba (Diseases of Workers). Although Ramazzini is perhaps most well known for his work on exposure to toxic materials, he wrote extensively about diseases of the musculoskeletal system. In particular, he warned of the problems of inactivity and poor postures inherent in some jobs.

Hematite-Rich Deposits in Capri Chasma

NASA Image and Video Library

2016-12-14

Capri Chasma is located in the eastern portion of the Valles Marineris canyon system, the largest known canyon system in the Solar System. Deeply incised canyons such as this are excellent targets for studying the Martian crust, as the walls may reveal many distinct types of bedrock. This section of the canyon was targeted by HiRISE based on a previous spectral detection of hematite-rich deposits in the area. Hematite, a common iron-oxide mineral, was first identified here by the Mars Global Surveyor Thermal Emission Spectrometer (TES). In this TES image, red pixels indicate higher abundances of hematite, while the blue and green pixels represent different types of volcanic rocks (e.g., basalt). Hematite in the Meridiani Planum region was also detected with the TES instrument (which we can see with the bright red spot on the Global TES mineral map). As a consequence, Meridiani Planum was the first landing site selected on Mars due to the spectral detection of a mineral that may have formed in the presence of liquid water. Shortly after landing, the Opportunity rover detected the presence of hematite in the form of concretions called "blueberries." The blueberries are found in association with layers of sulfate salt-rich rocks. The salts are hypothesized to have formed through the raising and lowering of the groundwater table. During one such an event, the rock altered to form the hematite-rich blueberries. As the rock was eroded away, the more resistant hematite-rich blueberries were plucked out and concentrated on the plains as a "lag" deposit. Martian blueberries are observed to be scattered across the plains of Meridiani along Opportunity's traverse from Eagle Crater to Endeavor Crater, where Opportunity continues to explore after its mission began over 10 years ago. This infrared-color image close-up highlights what is possibly the hematite-rich deposits nestled between different types of bedrock terraces in Capri Chasma. The bluish terrace is likely volcanic in origin, possibly basaltic, whereas the greenish rocks remain unidentified. The central reddish terrace is possibly where some of the hematite may be concentrated. The higher elevation terrace with the lighter-colored materials is likely a sulfate-rich rock (based on CRISM data in the area). Given the presence of both sulfate salts and hematite in this area, akin to the deposits and associations explored by the Opportunity rover in Meridiani Planum, it might be that these materials in Capri Chasma may share a similar origin. The yellow rectangular box shown on the TES spectral map outlines the corresponding location of the HiRISE image. Although the outline does not appear to contain a high hematite abundance, we note that the lower resolution of TES (about 3 to 6 kilometers per pixel) may exclude smaller exposures and finer sub-pixel details not-yet captured, but could be with HiRISE. A follow-up observation by the CRISM spectrometer may reveal additional details and a spectral signature for hematite in the vicinity at a finer resolution than TES. http://photojournal.jpl.nasa.gov/catalog/PIA21274

Probabilistic models for capturing more physicochemical properties on protein-protein interface.

PubMed

Guo, Fei; Li, Shuai Cheng; Du, Pufeng; Wang, Lusheng

2014-06-23

Protein-protein interactions play a key role in a multitude of biological processes, such as signal transduction, de novo drug design, immune responses, and enzymatic activities. It is of great interest to understand how proteins interact with each other. The general approach is to explore all possible poses and identify near-native ones with the energy function. The key issue here is to design an effective energy function, based on various physicochemical properties. In this paper, we first identify two new features, the coupled dihedral angles on the interfaces and the geometrical information on π-π interactions. We study these two features through statistical methods: a mixture of bivariate von Mises distributions is used to model the correlation of the coupled dihedral angles, while a mixture of bivariate normal distributions is used to model the orientation of the aromatic rings on π-π interactions. Using 6438 complexes, we parametrize the joint distribution of each new feature. Then, we propose a novel method to construct the energy function for protein-protein interface prediction, which includes the new features as well as the existing energy items such as dDFIRE energy, side-chain energy, atom contact energy, and amino acid energy. Experiments show that our method outperforms the state-of-the-art methods, ZRANK and ClusPro. We use the CAPRI evaluation criteria, Irmsd value, and Fnat value. On Benchmark v4.0, our method has an average Irmsd value of 3.39 Å and Fnat value of 62%, which improves upon the average Irmsd value of 3.89 Å and Fnat value of 49% for ZRANK, and the average Irmsd value of 3.99 Å and Fnat value of 46% for ClusPro. On the CAPRI targets, our method has an average Irmsd value of 3.56 Å and Fnat value of 42%, which improves upon the average Irmsd value of 4.27 Å and Fnat value of 39% for ZRANK, the average Irmsd value of 5.15 Å and Fnat value of 30% for ClusPro.

On the Use of CAD and Cartesian Methods for Aerodynamic Optimization

NASA Technical Reports Server (NTRS)

Nemec, M.; Aftosmis, M. J.; Pulliam, T. H.

2004-01-01

The objective for this paper is to present the development of an optimization capability for Curt3D, a Cartesian inviscid-flow analysis package. We present the construction of a new optimization framework and we focus on the following issues: 1) Component-based geometry parameterization approach using parametric-CAD models and CAPRI. A novel geometry server is introduced that addresses the issue of parallel efficiency while only sparingly consuming CAD resources; 2) The use of genetic and gradient-based algorithms for three-dimensional aerodynamic design problems. The influence of noise on the optimization methods is studied. Our goal is to create a responsive and automated framework that efficiently identifies design modifications that result in substantial performance improvements. In addition, we examine the architectural issues associated with the deployment of a CAD-based approach in a heterogeneous parallel computing environment that contains both CAD workstations and dedicated compute engines. We demonstrate the effectiveness of the framework for a design problem that features topology changes and complex geometry.

A modelling approach for the assessment of the effects of Common Agricultural Policy measures on farmland biodiversity in the EU27.

PubMed

Overmars, Koen P; Helming, John; van Zeijts, Henk; Jansson, Torbjörn; Terluin, Ida

2013-09-15

In this paper we describe a methodology to model the impacts of policy measures within the Common Agricultural Policy (CAP) on farm production, income and prices, and on farmland biodiversity. Two stylised scenarios are used to illustrate how the method works. The effects of CAP measures, such as subsidies and regulations, are calculated and translated into changes in land use and land-use intensity. These factors are then used to model biodiversity with a species-based indicator on a 1 km scale in the EU27. The Common Agricultural Policy Regionalised Impact Modelling System (CAPRI) is used to conduct the economic analysis and Dyna-CLUE (Conversion of Land Use and its Effects) is used to model land use changes. An indicator that expresses the relative species richness was used as the indicator for biodiversity in agricultural areas. The methodology is illustrated with a baseline scenario and two scenarios that include a specific policy. The strength of the methodology is that impacts of economic policy instruments can be linked to changes in agricultural production, prices and incomes, on the one hand, and to biodiversity effects, on the other - with land use and land-use intensity as the connecting drivers. The method provides an overall assessment, but for detailed impact assessment at landscape, farm or field level, additional analysis would be required. Copyright © 2013 Elsevier Ltd. All rights reserved.

In vitro assessment of the antimicrobial susceptibility of caprine isolates of Mycoplasma mycoides subsp. capri.

PubMed

Paterna, A; Tatay-Dualde, J; Amores, J; Prats-van der Ham, M; Sánchez, A; de la Fe, C; Contreras, A; Corrales, J C; Gómez-Martín, Á

2016-08-01

The minimum inhibitory concentration (MIC) and minimum mycoplasmacidal concentration (MMC) of 17 antimicrobials against 41 Spanish caprine isolates of Mycoplasma mycoides subsp. capri (Mmc) obtained from different specimens (milk, external auricular canal and semen) were determined using a liquid microdilution method. For half of the isolates, the MIC was also estimated for seven of the antimicrobials using an epsilometric test (ET), in order to compare both methods and assess the validity of ET. Mutations in genes gyrA, gyrB, parC and parE conferring fluoroquinolone resistance, which have been recently described in Mmc, were investigated using PCR. The anatomical origin of the isolate had no effect on its antimicrobial susceptibility. Moxifloxacin and doxycycline had the lowest MIC values. The rest of the fluoroquinolones studied (except norfloxacin), together with tylosin and clindamycin, also had low MIC values, although the MMC obtained for clindamycin was higher than for the other antimicrobials. For all the aminoglycosides, spiramycin and erythromycin, a notable level of resistance was observed. The ET was in close agreement with broth microdilution at low MICs, but not at intermediate or high MICs. The analysis of the genomic sequences revealed the presence of an amino acid substitution in codon 83 of the gene gyrA, which has not been described previously in Mmc. Copyright © 2016 Elsevier Ltd. All rights reserved.

[The Essen-based steel producer Alfred Krupp (1812-1887) as a reader of the flora and fauna of the Gulf of Naples. A look at the relationship of Anton Dohrn (1840-1909) to the house Krupp].

PubMed

Müller, Irmgard

2015-01-01

A unfavourable notice written by industrial magnate Alfred Krupp (1812-1887) has been discovered on the posterior cover sheet of the first volume of the monumental series Fauna und Flora des Golfes von Neapel, edited by the Zoological Station at Naples (1880) Krupp's handwritten statement affords the opportunity to discuss in more detail the intricate relationship between the founder of the first marine biology station, Anton Dohrn (1840-1909), and the owner of the greatest steel factory in Europe, the Krupp-family at Essen. Although Anton Dohrn did not know about Krupp's disapproving comment he had a fine unerring instinct for the mentality of his negotiating partner, whose way of thinking rather aimed at the practical success and completion of armament factory, preventing thus a the serious rapprochement between the two personalities. Even when the Krupp-heir, Friedrich Alfred Krupp, later devoted to questions about marine biology in his new built house at Capri, and was willing to support the Zoological Station with high sponsoring, Anton Dohrn maintained a reserved attitude towards the Krupp's offer to support the marine research financially. Likewise, he remained unimpressed, when the steel magnate was shook by the smear campaign in Capri that ultimately led to Krupp's death in November 1902.

GRAMM-X public web server for protein–protein docking

PubMed Central

Tovchigrechko, Andrey; Vakser, Ilya A.

2006-01-01

Protein docking software GRAMM-X and its web interface () extend the original GRAMM Fast Fourier Transformation methodology by employing smoothed potentials, refinement stage, and knowledge-based scoring. The web server frees users from complex installation of database-dependent parallel software and maintaining large hardware resources needed for protein docking simulations. Docking problems submitted to GRAMM-X server are processed by a 320 processor Linux cluster. The server was extensively tested by benchmarking, several months of public use, and participation in the CAPRI server track. PMID:16845016

Lazy river on Mars: Ring-shaped fluvial channel discovered north of Capri Chasma

NASA Astrophysics Data System (ADS)

Thomson, B. J.

2017-12-01

Many features on Mars are strange, but some are stranger than others. Fluvial features on Mars come in several basic flavors: branching valley networks, massive outflow channels, and possibly presently active recurring slope lineae. Here, we identify a small, valley network-like channel segment whose planform appearance traces out a nearly complete circle. One of the key tenants of hydrogeology and plumbing is that "stuff flows downhill." A seemingly circular loop implies a gross violation of the downhill flow rule, akin to a visual claim of perpetual motion. This M.C. Escher-inspired landform is located at 6.45°S, 39.70°W inside Innsbruck crater, a 59-km diameter impact structure that is just north of Capri Chasma. A close inspection reveals that the loop is not 100% continuous; there is a slight break on the western side of the loop. The pair of channels on either side of this gap terminate abruptly. These appear to be points of origin rather than termini, although admittedly the direction(s) of flow within the channel segments are difficult to constrain uniquely. The overall morphology of this near-circular channel system implies a local source limited both in duration and volume. Assuming that the fluid involved was water, the volume of water was sufficient for incipient erosion of the terrain, but not sufficient to have ponded or continued to flow. Here, the combined infiltration and evaporation rates must have been sufficiently large such that a breakout flow did not occur.

Electromechanical coupling of the solar atmosphere; Proceedings of the OSL Workshop, Capri, Italy, May 27-31, 1991

NASA Technical Reports Server (NTRS)

Spicer, Daniel S. (Editor); Macneice, Peter (Editor)

1992-01-01

The present conference discusses the role of magnetic flux tubes as communication channels, flux tube sizes and their temporal evolution, magnetic field line topology in the solar active regions, weak solar magnetic fields, explosive events and magnetic reconnection in the solar atmosphere, and 3D kinematic reconnection of plasmoids with nulls. Also discussed are coronal heating mechanisms, coronal heating through a lack of MHD equilibrium, Alfven waves in current-carrying inhomogeneous plasmas, hydrostatic models of X-ray coronal loops, MHD turbulence in an expanding atmosphere, and hot mass transport in the solar active prominence.

Bay of Naples, Italy

NASA Image and Video Library

1981-04-14

STS001-13-442 (14 April 1981) --- This photograph showing much of Italy was taken with a handheld 70mm camera from 276 kilometers above Earth as the NASA space shuttle Columbia and its crew were marking their last few hours in space on the historic first space mission utilizing a reusable vehicle. Included in the area of the frame are Golfo de Napoli, Napoli (Naples), Castellammare, Amalfi, Capri, Sorrento, Mt. Vesuvius and the ruins of Pompei. Astronauts John W. Young and Robert L. Crippen exposed eight magazines of color 70mm film during their two and one-third days in Earth orbit. Photo credit: NASA

Emissions from diesel and stratified charge powered cars. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Springer, K.J.

A total of ten passenger cars, four powered by diesel engines, two by stratified charge gasoline engines, one by a stratified charge operating on gasoline and diesel fuel, two by control equipped conventional engines, and one powered by a gas turbine, have been subjected to a wide variety of emissions evaluations. The vehicles, all late model, low mileage, included a Nissan Datsun, a Mercedes 220D, a Peugeot 504D, an Opel Rekord 2100D, a standard Capri, a stratified charge (PROCO) Capri, a low emission prototype Ford LTD, the Texaco TCCS stratified charge powered Cricket operated on gasoline and on diesel fuel,more » a Honda CVCC stratified charge, and a Chrysler gas turbine car. All were 4-cylinder except the LTD and the gas turbine. Tailpipe emissions were measured by the 1975 light duty Federal Test Procedure for gaseous emissions. Smoke and fuel economy were also determined during this test cycle. Chassis dynamometer versions of the 1974 heavy duty diesel smoke and gaseous emissions tests were employed. Odor and related instrumental-chemical measurements were made under seven steady state and three acceleration conditions. The prototype diesel odor analytical system, developed under CRC contract, was applied to the exhaust from both diesel and gasoline engines. Its use as a predictive method of diesel odor was investigated. Noise measurements were taken by SAE driveby as well as under a variety of exterior-interior conditions. Comparisons of the results for all vehicles are by emission category. The emissions from the group of diesel cars are compared to the conventional gasoline, Ford PROCO, Texas TCCS, and Honda CVCC.« less

Extending RosettaDock with water, sugar, and pH for prediction of complex structures and affinities for CAPRI rounds 20-27.

PubMed

Kilambi, Krishna Praneeth; Pacella, Michael S; Xu, Jianqing; Labonte, Jason W; Porter, Justin R; Muthu, Pravin; Drew, Kevin; Kuroda, Daisuke; Schueler-Furman, Ora; Bonneau, Richard; Gray, Jeffrey J

2013-12-01

Rounds 20-27 of the Critical Assessment of PRotein Interactions (CAPRI) provided a testing platform for computational methods designed to address a wide range of challenges. The diverse targets drove the creation of and new combinations of computational tools. In this study, RosettaDock and other novel Rosetta protocols were used to successfully predict four of the 10 blind targets. For example, for DNase domain of Colicin E2-Im2 immunity protein, RosettaDock and RosettaLigand were used to predict the positions of water molecules at the interface, recovering 46% of the native water-mediated contacts. For α-repeat Rep4-Rep2 and g-type lysozyme-PliG inhibitor complexes, homology models were built and standard and pH-sensitive docking algorithms were used to generate structures with interface RMSD values of 3.3 Å and 2.0 Å, respectively. A novel flexible sugar-protein docking protocol was also developed and used for structure prediction of the BT4661-heparin-like saccharide complex, recovering 71% of the native contacts. Challenges remain in the generation of accurate homology models for protein mutants and sampling during global docking. On proteins designed to bind influenza hemagglutinin, only about half of the mutations were identified that affect binding (T55: 54%; T56: 48%). The prediction of the structure of the xylanase complex involving homology modeling and multidomain docking pushed the limits of global conformational sampling and did not result in any successful prediction. The diversity of problems at hand requires computational algorithms to be versatile; the recent additions to the Rosetta suite expand the capabilities to encompass more biologically realistic docking problems. Copyright © 2013 Wiley Periodicals, Inc.

Earth observations taken during STS-1 mission

NASA Image and Video Library

2009-06-24

STS001-13-443 (12-14 April 1981) --- This photograph showing much of Italy was taken with a hand-held 70mm camera from 276 kilometers above Earth as the NASA space shuttle Columbia and its crew were marking their last few hours in space on the historic first space mission utilizing a reusable vehicle. Included in the area of the frame are Golfo de Napoli, Napoli (Naples), Castellammare, Amalfi, Capri, Sorrento, Mt. Vesuvius and the ruins of Pompei. Astronauts John W. Young and Robert L. Crippen exposed eight magazines of color 70mm film during their two-and-one-third days in Earth orbit. Photo credit: NASA

Mt. Vesuvius and Naples, Italy as seen from STS-58

NASA Technical Reports Server (NTRS)

1993-01-01

The ancient eruption of Vesuvius (the volcanoe near the center of the frame) destroyed the town of Pompeii located on the southeast flank. But the larger town of Naples, between Vesuvius (to the south) and the large, circular, lake-filled caldera of Campi Flegrei (to the west) is also close to volcanic hazards. In this view, Naples is the gray urban area with substantial coastal development just northwest of Vesuvius. Other landmarks marking the Italian coast include the small island of Capri, just off the west-pointing peninsula, and the city of Salerno on the coast just south of the same peninsula.

Allergic rhinitis and its impact on work productivity in primary care practice and a comparison with other common diseases: The Cross-sectional study to evAluate work Productivity in allergic Rhinitis compared with other common dIseases (CAPRI) study

PubMed Central

de la Hoz Caballer, Belén; Rodríguez, Mercedes; Fraj, Juan; Cerecedo, Inmaculada; Antolín-Amérigo, Darío

2012-01-01

Background: Allergic rhinitis (AR) is a highly prevalent allergic disease and also counts among the 10 most frequent reasons for medical consultation. Its impact on quality of life (QoL) and work productivity has been established but comparisons with other diseases are rare in the literature. The aim of this study was to evaluate the impact of AR in health-related QoL (HRQoL) and work productivity in primary care patients, compared with other prevalent diseases such as hypertension, diabetes mellitus (DM) type II, and symptomatic depression. Methods: Six hundred sixteen patients were included in a multicenter cross-sectional observational study. A generic HRQoL questionnaire, 36-item Short Form, and a specific questionnaire, “Work Productivity and Activity Impairment” were handed out to measure QoL and work productivity impact of the diseases. To assess clinical severity with a comparable scale between diseases Clinical Global Impression (CGI) had been used. Results: Symptomatic depression was found to produce the greatest impairment on work productivity with a decrease of 59.5%, with significant differences compared with AR, hypertension, and DM type II (p < 0.05). Symptomatic depression was found to produce the highest negative impact on daily activities with a statistically significant reduction of 59.4% (p < 0.05) compared with AR (26.6% decrease), hypertension (8.8% decrease), and DM (16.7% decrease) patients. Differences between AR and DM or hypertension were also significant (p < 0.05). Restriction on daily activities for AR was 27.8%, which is significantly higher (p < 0.05) than hypertension (19.8% decrease) but not DM (25.7% decrease). Depression had the highest impairment on daily activities (59.4%), compared with the remaining three groups (p < 0.05). Conclusion: AR impairs work productivity in a greater magnitude than hypertension and DM type II. PMID:23168153

Allergic rhinitis and its impact on work productivity in primary care practice and a comparison with other common diseases: the Cross-sectional study to evAluate work Productivity in allergic Rhinitis compared with other common dIseases (CAPRI) study.

PubMed

de la Hoz Caballer, Belén; Rodríguez, Mercedes; Fraj, Juan; Cerecedo, Inmaculada; Antolín-Amérigo, Darío; Colás, Carlos

2012-01-01

Allergic rhinitis (AR) is a highly prevalent allergic disease and also counts among the 10 most frequent reasons for medical consultation. Its impact on quality of life (QoL) and work productivity has been established but comparisons with other diseases are rare in the literature. The aim of this study was to evaluate the impact of AR in health-related QoL (HRQoL) and work productivity in primary care patients, compared with other prevalent diseases such as hypertension, diabetes mellitus (DM) type II, and symptomatic depression. Six hundred sixteen patients were included in a multicenter cross-sectional observational study. A generic HRQoL questionnaire, 36-item Short Form, and a specific questionnaire, "Work Productivity and Activity Impairment" were handed out to measure QoL and work productivity impact of the diseases. To assess clinical severity with a comparable scale between diseases Clinical Global Impression (CGI) had been used. Symptomatic depression was found to produce the greatest impairment on work productivity with a decrease of 59.5%, with significant differences compared with AR, hypertension, and DM type II (p < 0.05). Symptomatic depression was found to produce the highest negative impact on daily activities with a statistically significant reduction of 59.4% (p < 0.05) compared with AR (26.6% decrease), hypertension (8.8% decrease), and DM (16.7% decrease) patients. Differences between AR and DM or hypertension were also significant (p < 0.05). Restriction on daily activities for AR was 27.8%, which is significantly higher (p < 0.05) than hypertension (19.8% decrease) but not DM (25.7% decrease). Depression had the highest impairment on daily activities (59.4%), compared with the remaining three groups (p < 0.05). AR impairs work productivity in a greater magnitude than hypertension and DM type II.

Mt. Vesuvius and Naples, Italy as seen from STS-58

NASA Image and Video Library

1993-10-20

STS058-73-024 (18 Oct-1 Nov 1993) --- The ancient eruption of Vesuvius (the volcano near the center of the frame) destroyed the town of Pompeii located on its southeast flank. But the larger town of Naples, between Vesuvius (to the south) and the large, circular, lake-filled caldera of Campi Flegrei (to the west) also lives with the constant threat of volcanic hazards. In this view, Naples is the gray urban area with substantial coastal development just northwest of Vesuvius. Other landmarks marking the Italian coast include the small island of Capri, just off the west-pointing peninsula, and the city of Salerno on the coast just south of the same peninsula.

SU-F-T-35: Optimization of Bladder and Rectal Doses Using a Multi-Lumen Intracavitary Applicator for Gynecological Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laoui, S; Dietrich, S; Sehgal, V

2016-06-15

Purpose: Radiation dose delivery for endometrial cancer using HDR techniques is limited by dose to bladder and rectum. A dosimetric study was performed using Varian Capri vaginal brachytherapy applicator to determine the optimal channel configuration which minimizes dose to bladder and rectum, while providing good target coverage. Methods: A total of 17 patients, 63 plans clinically delivered, and 252 simulated plans using Varian BrachyVision planning system were generated to investigate optimal channel configuration which results in minimum dose to bladder and rectum while providing adequate target coverage. The Capri applicator consists of 13 lumens arranged in two concentric rings, onemore » central lumen and six lumens per ring. Manual dose shaping is invariably required to lower the dose to critical organs. Three-dimensional plans were simulated for 4 channel arrangements, all 13 channels, channel 12 o’clock (close to bladder) and 6 o’clock (close to rectum) deactivated, central channel deactivated, and central channel in addition to 12 o’clock and 6 o’clock deactivated. A relationship between V100, the volume that receives the prescribed dose, and the amount of curie-seconds required to deliver it, was established. Results: Using all 13 channels results in maximum dose to bladder and rectum. Deactivating central channel in addition to 12 o’clock and 6 o’clock resulted in minimizing bladder and rectum doses but compromised target coverage. The relationship between V100, the volume that receives the prescribed dose, and the curie seconds was found to be linear. Conclusion: Deactivating channels 12 o’clock and 6 o’clock was shown to be the optimal configuration leading to minimum dose to bladder and rectum without compromising target coverage. The linear relationship between V100 and the curie- seconds can be used as a verification parameter.« less

Spacelab to Space Station; Proceedings of the International Symposium on Spacelab 1 - Results, Implications and Perspectives, Naples and Capri, Italy, June 11-16, 1984

NASA Technical Reports Server (NTRS)

Napolitano, L. G. (Editor)

1985-01-01

Consideration is given to the scientific objectives of the Spacelab program, a review of data obtained during the STS-9/Spacelab 1 mission on board the Shuttle, and the coordination of future Spacelab research among participating European nations. Among the specific fields of study covered by Spacelab 1 were space plasma physics, materials and fluid sciences and technology, astronomy and solar physics, and atmospheric physics and earth observations. Consideration is also given to the legal aspects of space manufacturing activities, the role of private industry in space-based manufacturing ventures, plant production and breeding in space, and the development of remote sensing systems for use in a microgravity environment.

Stratigraphy and erosional landforms of layered deposits in Valles Marineris, Mars

NASA Technical Reports Server (NTRS)

Komatsu, G.; Geissler, P. E.; Strom, R. G.; Singer, R. B.

1993-01-01

Satellite imagery is used to identify stratigraphy and erosional landforms of 13 layered deposits in the Valles Marineris region of Mars (occurring, specifically, in Gangis, Juventae, Hebes, Ophir-Candor, Melas, and Capri-Eos Chasmata), based on albedo and erosional styles. Results of stratigraphic correlations show that the stratigraphy of layered deposits in the Hebes, Juventae, and Gangis Chasmata are not well correlated, indicating that at least these chasmata had isolated depositional environments resulting in different stratigraphic sequences. On the other hand, the layered deposits in Ophir-Candor and Melas Chasmata appear to have been connected in each chasma. Some of the layered deposits display complexities which indicate changes in space and time in the dominant source materials.

A generic probability based model to derive regional patterns of crops in time and space

NASA Astrophysics Data System (ADS)

Wattenbach, Martin; Luedtke, Stefan; Redweik, Richard; van Oijen, Marcel; Balkovic, Juraj; Reinds, Gert Jan

2015-04-01

Croplands are not only the key to human food supply, they also change the biophysical and biogeochemical properties of the land surface leading to changes in the water cycle, energy portioning, they influence soil erosion and substantially contribute to the amount of greenhouse gases entering the atmosphere. The effects of croplands on the environment depend on the type of crop and the associated management which both are related to the site conditions, economic boundary settings as well as preferences of individual farmers. The method described here is designed to predict the most probable crop to appear at a given location and time. The method uses statistical crop area information on NUTS2 level from EUROSTAT and the Common Agricultural Policy Regionalized Impact Model (CAPRI) as observation. These crops are then spatially disaggregated to the 1 x 1 km grid scale within the region, using the assumption that the probability of a crop appearing at a given location and a given year depends on a) the suitability of the land for the cultivation of the crop derived from the MARS Crop Yield Forecast System (MCYFS) and b) expert knowledge of agricultural practices. The latter includes knowledge concerning the feasibility of one crop following another (e.g. a late-maturing crop might leave too little time for the establishment of a winter cereal crop) and the need to combat weed infestations or crop diseases. The model is implemented in R and PostGIS. The quality of the generated crop sequences per grid cell is evaluated on the basis of the given statistics reported by the joint EU/CAPRI database. The assessment is given on NUTS2 level using per cent bias as a measure with a threshold of 15% as minimum quality. The results clearly indicates that crops with a large relative share within the administrative unit are not as error prone as crops that allocate only minor parts of the unit. However, still roughly 40% show an absolute per cent bias above the 15% threshold. This highlights the discrepancy between the best practice given the soil properties within an administrative unit and the effectively cultivated crops.

Chryse Outflow Channel

NASA Image and Video Library

1998-06-08

A color image of the south Chryse basin Valles Marineris outflow channels on Mars; north toward top. The scene shows on the southwest corner the chaotic terrain of the east part of Valles Marineris and two of its related canyons: Eos and Capri Chasmata (south to north). Ganges Chasma lies directly north. The chaos in the southern part of the image gives rise to several outflow channels, Shalbatana, Simud, Tiu, and Ares Valles (left to right), that drained north into the Chryse basin. The mouth of Ares Valles is the site of the Mars Pathfinder lander. This image is a composite of NASA's Viking medium-resolution images in black and white and low-resolution images in color. The image extends from latitude 20 degrees S. to 20 degrees N. and from longitude 15 degrees to 53 degrees; Mercator projection. http://photojournal.jpl.nasa.gov/catalog/PIA00418

Phytotoxicity and growth responses of ornamental bedding plants to ozone and sulfur dioxide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adedipe, N.O.; Barrett, R.F.; Ormrod, D.P.

No appreciable signs of phytotoxicity were observed for 4 days following fumigation of plants (including begonias, petunias, snapdragons) with ozone of up to 80 parts per hundred million or sulfur dioxide of up to 400 pphm for 2 hr. Thereafter, there was considerable necrosis, particularly on begonias fumigated with the highest concentration of the pollutants. Growth suppression was reflected in reduced shoot and flower wt, and to a lesser degree in reduced flower number. Overall, begonias and petunias were the most sensitive. Coleus and snapdragons were moderately sensitive, while marigold, celosia, impatiens and salvia were tolerant. White Tausendschon was themore » most sensitive begonia cultivar while blue-flowered Capri was the most sensitive petunia. Mixed color petunias exhibited varying degrees of tolerance. Scarlet rainbow coleus was more sensitive than Pastel Rainbow. Measurements of growth alterations in plants were found very useful in determining latent forms of air pollutant injury.« less

Preliminary results from the Viking orbiter imaging experiment

USGS Publications Warehouse

Carr, M.H.; Masursky, H.; Baum, W.A.; Blasius, K.R.; Briggs, G.A.; Cutts, J.A.; Duxbury, T.; Greeley, R.; Guest, J.E.; Smith, B.A.; Soderblom, L.A.; Veverka, J.; Wellman, J.B.

1976-01-01

During its first 30 orbits around Mars, the Viking orbiter took approximately 1000 photographic frames of the surface of Mars with resolutions that ranged from 100 meters to a little more than 1 kilometer. Most were of potential landing sites in Chryse Planitia and Cydonia and near Capri Chasma. Contiguous high-resolution coverage in these areas has led to an increased understanding of surface processes, particularly cratering, fluvial, and mass-wasting phenomena. Most of the surfaces examined appear relatively old, channel features abound, and a variety of features suggestive of permafrost have been identified. The ejecta patterns around large craters imply that fluid flow of ejecta occurred after ballistic deposition. Variable features in the photographed area appear to have changed little since observed 5 years ago from Mariner 9. A variety of atmospheric phenomena were observed, including diffuse morning hazes, both stationary and moving discrete white clouds, and wave clouds covering extensive areas.

On the potential roles of ticks and migrating birds in the ecology of West Nile virus.

PubMed

Hagman, Karl; Barboutis, Christos; Ehrenborg, Christian; Fransson, Thord; Jaenson, Thomas G T; Lindgren, Per-Eric; Lundkvist, Ake; Nyström, Fredrik; Waldenström, Jonas; Salaneck, Erik

2014-01-15

Mosquitoes are the primary vectors of West Nile virus (WNV). Ticks have, however, been suggested to be potential reservoirs of WNV. In order to investigate their role in the spread of the virus, ticks, which had been collected from birds migrating northwards from Africa to Europe, were analyzed for the potential presence of WNV-RNA. On the Mediterranean islands Capri and Antikythira a total of 14,824 birds were captured and investigated from which 747 ticks were collected. Most of the identified ticks (93%) were nymphs and larvae of Hyalomma marginatum sensu lato, most of which were or appear to be Hyalomma rufipes. Of these ticks 729 were individually screened for WNV-RNA. None of the ticks was found to be WNV positive. Thus, there was no evidence that Hyalomma marginatum s.l. ticks play a role in the spread of WNV from Africa to Europe.

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-09-28

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in eastern Coprates Chasma. The image shows a relatively smooth floor, with a group of sand dune forms located against the wall of the chasma (bottom of image). The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 27061 Latitude: -13.9602 Longitude: 301.82 Instrument: VIS Captured: 2008-01-20 10:39 https://photojournal.jpl.nasa.gov/catalog/PIA21993

Comparison of Circulating Endothelial Cell/Platelet Count Ratio to Aspartate Transaminase/Platelet Ratio Index for Identifying Patients with Cirrhosis

PubMed Central

Sethi, Saurabh; Simonetto, Douglas A; Abdelmoneim, Soha S; Campion, Michael B; Kaloiani, Irakli; Clayton, Amy C; Kremers, Walter K; Halling, Kevin C; Kamath, Patrick S; Talwalkar, Jayant; Shah, Vijay H

2012-01-01

Background/Objectives Circulating endothelial cells (CECs) are indicative of vascular injury and correlate with severity of vascular diseases. A pilot study showed that the ratio of CEC to platelet count (CEC/PC) was effective in predicting cirrhosis. Therefore, we evaluated CEC/PC in a larger cohort of patients, correlated it with cirrhosis, and compared its operating characteristics with previously described biomarker for cirrhosis, the AST/platelet ratio index (APRI). Methods Fifty-three patients with cirrhosis, 20 matched healthy controls, and 9 patients with noncirrhotic liver disease were recruited. Peripheral blood sample was collected and analyzed to enumerate nucleated CEC CD146+, CD105+, CD45– using a commercial assay. Results Median CEC counts were significantly higher in patients with cirrhosis (62 cells/4 mL, interquartile range [IQR]: 43.5–121) as compared with controls (31 cells/4 mL, IQR: 22.2–40). The CEC/PC was also significantly elevated in cirrhotics (0.69, IQR: 0.39–1.48) compared with controls (0.12, IQR: 0.09–0.20) and noncirrhotics (0.21, IQR: 0.08–0.43). Receiver operator characteristic (ROC) analysis revealed that CEC cutoff value of ≥37 cells/4 mL showed sensitivity of 81% and specificity of 75% for differentiating cirrhosis from controls (area under the curve [AUC]: 0.80; 95% confidence interval [CI] 0.67–0.91). The CEC/PC ratio cutoff value of ≥0.23 showed sensitivity of 91% and specificity of 82% (AUC: 0.92; 95% CI 0.83–0.99). The APRI cutoff value of ≥0.4 showed sensitivity of 94% and specificity of 85% for differentiating cirrhosis from control patients (AUC: 0.96; 95% CI 0.90–1.0). A product of CEC and APRI, termed CAPRI (CEC-APRI), effectively distinguished patients with cirrhosis from controls; with cutoff value of ≥12.7, showing higher sensitivity of 98% and specificity of 85% (AUC: 0.98; 95% CI 0.96–1.0). Conclusion The CEC/PC ratio is significantly elevated in patients with cirrhosis and demonstrates comparable operating characteristics to previously described APRI. Furthermore, CAPRI, compiled as product of CEC to APRI showed outstanding ability to distinguish patients with cirrhosis from controls, although larger studies are necessary for validation. PMID:25755402

RAS testing of liquid biopsy correlates with the outcome of metastatic colorectal cancer patients treated with first-line FOLFIRI plus cetuximab in the CAPRI-GOIM trial.

PubMed

Normanno, N; Esposito Abate, R; Lambiase, M; Forgione, L; Cardone, C; Iannaccone, A; Sacco, A; Rachiglio, A M; Martinelli, E; Rizzi, D; Pisconti, S; Biglietto, M; Bordonaro, R; Troiani, T; Latiano, T P; Giuliani, F; Leo, S; Rinaldi, A; Maiello, E; Ciardiello, F

2018-01-01

Liquid biopsy is an alternative to tissue for RAS testing in metastatic colorectal carcinoma (mCRC) patients. Little information is available on the predictive role of liquid biopsy RAS testing in patients treated with first-line anti-EGFR monoclonal antibody-based therapy. In the CAPRI-GOIM trial, 340 KRAS exon-2 wild-type mCRC patients received first-line cetuximab plus FOLFIRI. Tumor samples were retrospectively assessed by next generation sequencing (NGS). Baseline plasma samples were analyzed for KRAS and NRAS mutations using beads, emulsion, amplification, and magnetics digital PCR (BEAMing). Discordant cases were solved by droplet digital PCR (ddPCR) or deep-sequencing. A subgroup of 92 patients with available both NGS data on tumor samples and baseline plasma samples were included in this study. Both NGS analysis of tumor tissue and plasma testing with BEAMing identified RAS mutations in 33/92 patients (35.9%). However, 10 cases were RAS tissue mutant and plasma wild-type, and additional 10 cases were tissue wild-type and plasma mutant, resulting in a concordance rate of 78.3%. Analysis of plasma samples with ddPCR detected RAS mutations in 2/10 tissue mutant, plasma wild-type patients. In contrast, in all tissue wild-type and plasma mutant cases, ddPCR or deep-sequencing analysis of tumor tissue confirmed the presence of RAS mutations at allelic frequencies ranging between 0.15% and 1.15%. The median progression-free survival of RAS mutant and wild-type patients according to tissue (7.9 versus 12.6 months; P = 0.004) and liquid biopsy testing (7.8 versus 13.8 moths; P < 0.001) were comparable. Similar findings were observed for the median overall survival of RAS mutant and wild-type patients based on tissue (22.1 versus 35.8 months; P = 0.016) and plasma (19.9 versus 35.8 months; P = 0.013) analysis. This study indicates that RAS testing of liquid biopsy results in a similar outcome when compared with tissue testing in mCRC patients receiving first-line anti-EGFR monoclonal antibodies. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Comparing impacts of climate change and mitigation on global agriculture by 2050

NASA Astrophysics Data System (ADS)

van Meijl, Hans; Havlik, Petr; Lotze-Campen, Hermann; Stehfest, Elke; Witzke, Peter; Pérez Domínguez, Ignacio; Bodirsky, Benjamin Leon; van Dijk, Michiel; Doelman, Jonathan; Fellmann, Thomas; Humpenöder, Florian; Koopman, Jason F. L.; Müller, Christoph; Popp, Alexander; Tabeau, Andrzej; Valin, Hugo; van Zeist, Willem-Jan

2018-06-01

Systematic model inter-comparison helps to narrow discrepancies in the analysis of the future impact of climate change on agricultural production. This paper presents a set of alternative scenarios by five global climate and agro-economic models. Covering integrated assessment (IMAGE), partial equilibrium (CAPRI, GLOBIOM, MAgPIE) and computable general equilibrium (MAGNET) models ensures a good coverage of biophysical and economic agricultural features. These models are harmonized with respect to basic model drivers, to assess the range of potential impacts of climate change on the agricultural sector by 2050. Moreover, they quantify the economic consequences of stringent global emission mitigation efforts, such as non-CO2 emission taxes and land-based mitigation options, to stabilize global warming at 2 °C by the end of the century under different Shared Socioeconomic Pathways. A key contribution of the paper is a vis-à-vis comparison of climate change impacts relative to the impact of mitigation measures. In addition, our scenario design allows assessing the impact of the residual climate change on the mitigation challenge. From a global perspective, the impact of climate change on agricultural production by mid-century is negative but small. A larger negative effect on agricultural production, most pronounced for ruminant meat production, is observed when emission mitigation measures compliant with a 2 °C target are put in place. Our results indicate that a mitigation strategy that embeds residual climate change effects (RCP2.6) has a negative impact on global agricultural production relative to a no-mitigation strategy with stronger climate impacts (RCP6.0). However, this is partially due to the limited impact of the climate change scenarios by 2050. The magnitude of price changes is different amongst models due to methodological differences. Further research to achieve a better harmonization is needed, especially regarding endogenous food and feed demand, including substitution across individual commodities, and endogenous technological change.

A collaborative filtering approach for protein-protein docking scoring functions.

PubMed

Bourquard, Thomas; Bernauer, Julie; Azé, Jérôme; Poupon, Anne

2011-04-22

A protein-protein docking procedure traditionally consists in two successive tasks: a search algorithm generates a large number of candidate conformations mimicking the complex existing in vivo between two proteins, and a scoring function is used to rank them in order to extract a native-like one. We have already shown that using Voronoi constructions and a well chosen set of parameters, an accurate scoring function could be designed and optimized. However to be able to perform large-scale in silico exploration of the interactome, a near-native solution has to be found in the ten best-ranked solutions. This cannot yet be guaranteed by any of the existing scoring functions. In this work, we introduce a new procedure for conformation ranking. We previously developed a set of scoring functions where learning was performed using a genetic algorithm. These functions were used to assign a rank to each possible conformation. We now have a refined rank using different classifiers (decision trees, rules and support vector machines) in a collaborative filtering scheme. The scoring function newly obtained is evaluated using 10 fold cross-validation, and compared to the functions obtained using either genetic algorithms or collaborative filtering taken separately. This new approach was successfully applied to the CAPRI scoring ensembles. We show that for 10 targets out of 12, we are able to find a near-native conformation in the 10 best ranked solutions. Moreover, for 6 of them, the near-native conformation selected is of high accuracy. Finally, we show that this function dramatically enriches the 100 best-ranking conformations in near-native structures.

A Collaborative Filtering Approach for Protein-Protein Docking Scoring Functions

PubMed Central

Bourquard, Thomas; Bernauer, Julie; Azé, Jérôme; Poupon, Anne

2011-01-01

A protein-protein docking procedure traditionally consists in two successive tasks: a search algorithm generates a large number of candidate conformations mimicking the complex existing in vivo between two proteins, and a scoring function is used to rank them in order to extract a native-like one. We have already shown that using Voronoi constructions and a well chosen set of parameters, an accurate scoring function could be designed and optimized. However to be able to perform large-scale in silico exploration of the interactome, a near-native solution has to be found in the ten best-ranked solutions. This cannot yet be guaranteed by any of the existing scoring functions. In this work, we introduce a new procedure for conformation ranking. We previously developed a set of scoring functions where learning was performed using a genetic algorithm. These functions were used to assign a rank to each possible conformation. We now have a refined rank using different classifiers (decision trees, rules and support vector machines) in a collaborative filtering scheme. The scoring function newly obtained is evaluated using 10 fold cross-validation, and compared to the functions obtained using either genetic algorithms or collaborative filtering taken separately. This new approach was successfully applied to the CAPRI scoring ensembles. We show that for 10 targets out of 12, we are able to find a near-native conformation in the 10 best ranked solutions. Moreover, for 6 of them, the near-native conformation selected is of high accuracy. Finally, we show that this function dramatically enriches the 100 best-ranking conformations in near-native structures. PMID:21526112

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-09-29

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in central Coprates Chasma. The floor of the chasma is covered by a complex deposit of material. This chaotic surface differs from most of the floor of the canyon and indicate a local process, perhaps a very large landslide or failure of the cliff face. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 27086 Latitude: -13.564 Longitude: 300.618 Instrument: VIS Captured: 2008-01-22 12:04 https://photojournal.jpl.nasa.gov/catalog/PIA21994

Headward growth of chasmata by volatile outbursts, collapse, and drainage: Evidence from ganges chaos, Mars

USGS Publications Warehouse

Rodriguez, J.A.P.; Kargel, J.; Crown, D.A.; Bleamaster, L. F.; Tanaka, K.L.; Baker, V.; Miyamoto, H.; Dohm, J.M.; Sasaki, S.; Komatsu, G.

2006-01-01

The nature and significance of collapse processes in Capri, Eos, and Ganges Chasmata remain poorly understood. Using Ganges Chasma as a type locality, these chasmata are interpreted to be the result of clustering and assimilation of multiple chaotic terrains, which primarily formed by localized depressurization-induced or thermally-triggered dissociation of buried gas clathrate hydrates and explosive eruption of gas-saturated ground water. Such crustal destabilization could have been triggered by (1) deep fracture propagation from the Martian surface, (2) magmatic intrusions and associated heating and inflation-induced terrain fracturing, and/or (3) climatic thaw and thinning/weakening of the permafrost over the clathrate and gas-rich groundwater zones. Volume increases associated with release of gases contributed to the xpulsion of groundwater and fluidized sediments at the surface, thereby carving the higher outflow channels peripheral to the chasmata and the lower outflow channel floors of the chasmata and outflow channels. Copyright 2006 by the American Geophysical Union.

Likelihood ratio meta-analysis: New motivation and approach for an old method.

PubMed

Dormuth, Colin R; Filion, Kristian B; Platt, Robert W

2016-03-01

A 95% confidence interval (CI) in an updated meta-analysis may not have the expected 95% coverage. If a meta-analysis is simply updated with additional data, then the resulting 95% CI will be wrong because it will not have accounted for the fact that the earlier meta-analysis failed or succeeded to exclude the null. This situation can be avoided by using the likelihood ratio (LR) as a measure of evidence that does not depend on type-1 error. We show how an LR-based approach, first advanced by Goodman, can be used in a meta-analysis to pool data from separate studies to quantitatively assess where the total evidence points. The method works by estimating the log-likelihood ratio (LogLR) function from each study. Those functions are then summed to obtain a combined function, which is then used to retrieve the total effect estimate, and a corresponding 'intrinsic' confidence interval. Using as illustrations the CAPRIE trial of clopidogrel versus aspirin in the prevention of ischemic events, and our own meta-analysis of higher potency statins and the risk of acute kidney injury, we show that the LR-based method yields the same point estimate as the traditional analysis, but with an intrinsic confidence interval that is appropriately wider than the traditional 95% CI. The LR-based method can be used to conduct both fixed effect and random effects meta-analyses, it can be applied to old and new meta-analyses alike, and results can be presented in a format that is familiar to a meta-analytic audience. Copyright © 2016 Elsevier Inc. All rights reserved.

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-10-04

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in eastern Coprates Chasma. The branching features near the bottom of the image are spurs of rock in the cliff face. The rock is more resistant to erosion that fine materials like sand and dust. Those materials are visible below the spurs, and then onto the canyon floor. Unlike the large landslide deposits, these small fans of material build up over time as the material above erodes. There are sand dunes along the edge of the fans in this image. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 36294 Latitude: -14.7055 Longitude: 303.066 Instrument: VIS Captured: 2010-02-18 17:20 https://photojournal.jpl.nasa.gov/catalog/PIA21998

SETI from the moon: an invitation to COSPAR

NASA Astrophysics Data System (ADS)

Heidmann, J.

After presenting arguments for SETI (Search for ExtraTerrestrial Intelligence) work to be done well into the 21st century, and in view of the dramatic increase of blinding human-made radiofrequency interference, this author proposed that a well defined locale on the farside of the Moon - crater Saha - be preserved for the next 20-30 years not only for SETI but also for future high-sensitivity radioastronomy. The long-term programmatic issues were presented at the Lunar Exploration Symposium of the Jerusalem 1994 International Astronautical Federation Congress. The legal questions raised were delineated at the International Institute of Space Law (IISL) Colloquium of the same Jerusalem Congress. Numerous suggestions were given for an action strategy, in particular to present a proposal at a COSPAR venue. In the words of IISL Director A.A. Cocca: ``This reservation of a lunar zone for scientific activities, and its further utilization aiming at the common good of humanity, must be recognized, and constitutes a precedent.'' At the Hamburg 1995 European Geophysical Society XXth GA, we pointed out that this Saha project could offer interesting possibilities for a symbiosis with the `Science on the Moon Exobiology' teams. We also presented it at the Berlin 1996 European Space Agency/Deutsche Forschungsanstalt für Luft und Raumfahrt `International Moon Workshop' to geologists and to bioastrononomers at the Capri 1996 Bioastronomy International Astronomical Union Colloquium #161. At the 1995 IAF Congress in Oslo, the SETI Committee of the International Academy of Astronautics took action for the future benefit of humankind by setting-up a Sub-committee for `A SETI Lunar Study', chaired by the author. We hope that, in view of these initial endeavors, COSPAR may become interested in this Saha proposal and supports it.

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-10-05

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in eastern Coprates Chasma. The plateau above the chasma is visible in this image. The cliff face is very steep, with the elevation dropping over 3 miles from the plateau to the canyon floor. Craters are relatively rare on the chasma floor, the one in this image is fairly large. The crater rim has affected winds in this region, causing the interior dunes within the crater as well as the dunes outside the crater rim. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 37804 Latitude: -14.4843 Longitude: 302.193 Instrument: VIS Captured: 2010-06-23 01:14 https://photojournal.jpl.nasa.gov/catalog/PIA21999

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-10-06

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in central Coprates Chasma. The brighter materials at the bottom of the image are layered deposits. It is unknown how deep these canyon deposits were when they formed. The layering is only visible due to erosion, making it difficult to estimate the original thickness. While layered deposits can be found on the floor of Coprates Chasma, they are most commonly found along the lower elevations and at the bottom of the cliff faces in the canyon. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 51810 Latitude: -12.6848 Longitude: 295.197 Instrument: VIS Captured: 2013-08-18 22:56 https://photojournal.jpl.nasa.gov/catalog/PIA22000

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-10-03

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in central Coprates Chasma. In this image, there is a landslide deposit at the bottom of the image. The brighter material to the left of the landslide appears to be a rough surface likely etched by wind action. The chasma contains numerous regions of sand dunes, indicating that the wind plays a part in the erosion and deposition of fine materials in the canyon. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 35820 Latitude: -12.793 Longitude: 297.407 Instrument: VIS Captured: 2010-01-10 16:39 https://photojournal.jpl.nasa.gov/catalog/PIA21996

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-10-02

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in eastern Coprates Chasma, just east of the previous image. In this image, the lobate margins of several landslide deposits are easy to identify. This indicates the chaotic surface in yesterday's image are materials emplaced by landslides. The brighter features at the bottom of the image are layered materials. There are also dunes in the region with the layered deposits. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 33037 Latitude: -13.8409 Longitude: 301.104 Instrument: VIS Captured: 2009-05-26 13:16 https://photojournal.jpl.nasa.gov/catalog/PIA21995

Investigating Mars: Coprates Chasma

NASA Image and Video Library

2017-09-27

Coprates Chasma is one of the numerous canyons that make up Valles Marineris. The chasma stretches for 960 km (600 miles) from Melas Chasma to the west and Capri Chasma to the east. Landslide deposits, layered materials and sand dunes cover a large portion of the chasma floor. This image is located in central Coprates Chasma. The image shows multiple landslide features, which form the bright lobed shaped deposits at the bottom of the canyon cliff face (top of image). The linear grooves on the top of the large landslide deposit were formed as the material came to rest on the canyon floor. The other features on the chasma floor are layered materials that have been weathered. The Odyssey spacecraft has spent over 15 years in orbit around Mars, circling the planet more than 69000 times. It holds the record for longest working spacecraft at Mars. THEMIS, the IR/VIS camera system, has collected data for the entire mission and provides images covering all seasons and lighting conditions. Over the years many features of interest have received repeated imaging, building up a suite of images covering the entire feature. From the deepest chasma to the tallest volcano, individual dunes inside craters and dune fields that encircle the north pole, channels carved by water and lava, and a variety of other feature, THEMIS has imaged them all. For the next several months the image of the day will focus on the Tharsis volcanoes, the various chasmata of Valles Marineris, and the major dunes fields. We hope you enjoy these images! Orbit Number: 16803 Latitude: -12.5614 Longitude: 296.887 Instrument: VIS Captured: 2005-09-27 20:25 https://photojournal.jpl.nasa.gov/catalog/PIA21992

Protein-protein interaction specificity is captured by contact preferences and interface composition.

PubMed

Nadalin, Francesca; Carbone, Alessandra

2018-02-01

Large-scale computational docking will be increasingly used in future years to discriminate protein-protein interactions at the residue resolution. Complete cross-docking experiments make in silico reconstruction of protein-protein interaction networks a feasible goal. They ask for efficient and accurate screening of the millions structural conformations issued by the calculations. We propose CIPS (Combined Interface Propensity for decoy Scoring), a new pair potential combining interface composition with residue-residue contact preference. CIPS outperforms several other methods on screening docking solutions obtained either with all-atom or with coarse-grain rigid docking. Further testing on 28 CAPRI targets corroborates CIPS predictive power over existing methods. By combining CIPS with atomic potentials, discrimination of correct conformations in all-atom structures reaches optimal accuracy. The drastic reduction of candidate solutions produced by thousands of proteins docked against each other makes large-scale docking accessible to analysis. CIPS source code is freely available at http://www.lcqb.upmc.fr/CIPS. alessandra.carbone@lip6.fr. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

GalaxyRefineComplex: Refinement of protein-protein complex model structures driven by interface repacking.

PubMed

Heo, Lim; Lee, Hasup; Seok, Chaok

2016-08-18

Protein-protein docking methods have been widely used to gain an atomic-level understanding of protein interactions. However, docking methods that employ low-resolution energy functions are popular because of computational efficiency. Low-resolution docking tends to generate protein complex structures that are not fully optimized. GalaxyRefineComplex takes such low-resolution docking structures and refines them to improve model accuracy in terms of both interface contact and inter-protein orientation. This refinement method allows flexibility at the protein interface and in the overall docking structure to capture conformational changes that occur upon binding. Symmetric refinement is also provided for symmetric homo-complexes. This method was validated by refining models produced by available docking programs, including ZDOCK and M-ZDOCK, and was successfully applied to CAPRI targets in a blind fashion. An example of using the refinement method with an existing docking method for ligand binding mode prediction of a drug target is also presented. A web server that implements the method is freely available at http://galaxy.seoklab.org/refinecomplex.

EDITORIAL: Special section: Selected papers from OMS'05, the 1st Topical Meeting of the European Optical Society on Optical Microsystems (OMS)

NASA Astrophysics Data System (ADS)

Rendina, Ivo; Fazio, Eugenio; Ferraro, Pietro

2006-07-01

OMS'05 is the first international conference wholly dedicated to optical microsystems. It was organized by the European Optical Society (EOS) in the frame of its international topical meeting activity and was held in Italy, September 2005, amidst the wonderful scenery of the Island of Capri. A possible definition of an optical microsystem is a complex system, able to perform one or more sensing and actuation functions, where optical devices are integrated in a smart way with electronic, mechanical and sensing components by taking advantage of the progress in micro- and nano-technologies. The increasing interest in this field arises from the expected applications that would significantly improve the quality of life. The list of possibilities offered by the optical microsystem enabling technologies is very long and seems to increase day by day. We are not only thinking about the next generation of optical telecommunication networks and computers, but also about low-cost, compact microsystems for environmental monitoring, in order to improve safety in the avionic and automotive fields, medical diagnostics and proteomic/genomic studies, or just finding general applications in several industrial fields. The goal of the conference was to involve scientists and young researchers from the main public and private laboratories, giving them the opportunity to present new scientific results and compare their know-how in the exciting and emerging field of optical microsystems. We believe that we succeeded in this. More than 200 scientists from all over the world attended the conference. We had more than 100 oral presentations and approximately 20 from the keynote lectures and invited speeches. It was an opportunity to define the most recent progress carried out in the field and to outline the possible road-map leading to the expected results in the industrial and social fields. We strongly believe that research and technology are closely interconnected at present and cannot move forward separately. Thus, we wanted the meeting to encourage the cross-fertilization of ideas of all the people involved and active in the areas of optics, photonics, microelectronics and materials, by gathering together theoreticians, experimentalists and those interested in industrial applications. For these reasons the conference programme focused on fundamental as well as more applied topics. Photonic crystals, non-linear and quantum optics in micro-devices, nanophotonic-based devices, silicon-based optoelectronics and MOEMS, microsensors, biochips and the new characterization methods for materials and devices were among the hot topics of the conference. Special emphasis was also given to industrial applications and to technologies enabling the production of microsytems and their sub-components. In this special section of Journal of Optics A: Pure and Applied Optics, a series of interesting papers has been collected, reporting progress in the different aspects of microsystems design, production, characterization and testing. The papers embrace most of the various topics that were debated during the conference. We hope that these papers will not only report the most up-to-date research progress made in this field, but will also involve and stimulate everyone working in these areas to continue in the effort of developing more and better optical microsystems in the future. We would like to thank all the members of the Scientific and Industrial Committees for the high scientific content of the meeting and the European Optical Society for its support of the conference organization.

Recent results of Daya Bay reactor neutrino experiment

NASA Astrophysics Data System (ADS)

Leitner, R.; Daya Bay Collaboration

2017-04-01

The Daya Bay reactor neutrino experiment has been designed to precisely measure the least known neutrino mixing angle θ13. In March 2012, Daya Bay collaboration announced [Daya Bay Collaboration (F. P. An et al.), Observation of electron-antineutrino disappearance at Daya Bay, Phys. Rev. Lett. 108 (2012) 171803] the observation of non-zero value of sin2 ⁡ 2θ13. Because of large statistics of detected antineutrinos and excellent performance of the experiment, Daya Bay continuously improves the precision of world best measurement of sin2 ⁡ 2θ13. In addition it provides results on neutrino mass splitting Δ mee2 competitive with measurements of other experiments, results on precise measurement of reactor fluxes and on limits of the existence of hypothetical fourth neutrino. In this paper, we report the results available by the time of the 6th Capri workshop: the measurement of oscillation parameters sin2 ⁡ (2θ13) = 0.084 ± 0.005 and | Δmee2 | = (2.42 ± 0.11) ×10-3eV2 [Daya Bay Collaboration (F. P. An et al.), New Measurement of Antineutrino Oscillation with the Full Detector Configuration at Daya Bay, Phys. Rev. Lett. 115 (2015) no. 11, 111802], searches for sterile neutrinos [Daya Bay Collaboration (F. P. An et al.) Search for a Light Sterile Neutrino at Daya Bay, Phys. Rev. Lett. 113 (2014) 141802] and precise measurement of reactor neutrino flux [Daya Bay Collaboration (F. P. An et al.), Measurement of the Reactor Anti-neutrino Flux and Spectrum at Daya Bay, Phys. Rev. Lett. 116 (2016) no. 6, 061801]. These are based on 621 days of measurement, most of the data has been taken in full detector configuration. More precise results [Daya Bay Collaboration (F. P. An et al.), Measurement of electron antineutrino oscillation based on 1230 days of operation of the Daya Bay experiment, arxiv:arXiv:1610.04802] with 1230 days of operation have been presented few weeks later at the Neutrino 2016 conference.

Studies into the prevalence of Mycoplasma species in small ruminants in Benue State, North-central Nigeria.

PubMed

Akwuobu, Chinedu A; Ayling, Roger D; Chah, Kennedy Foinkfu; Oboegbulem, Stephen I

2014-08-01

The indicative prevalence of respiratory Mycoplasma species in small ruminants (SR) was determined in North-central Nigeria. Nasal swabs from 172 sheep and 336 goats from the Northeast, Northwest and South Senatorial Districts of Benue State were examined. Initial Mycoplasma isolation used Mycoplasma culture techniques followed by digitonin sensitivity testing. Species identification was done using polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE). Overall, Mycoplasma organisms were isolated from 131 (25.8 %) of the 508 SR examined. Prevalence rates of 18.1 and 29.8 % were recorded for sheep and goats, respectively. A total of 135 isolates of Mycoplasma belonging to three different species were identified: Mycoplasma ovipneumoniae (127), Mycoplasma arginini (7) and Mycoplasma mycoides subspecies capri (1). More than one Mycoplasma species were detected in four (3.1 %) of the 131 confirmed Mycoplasma positive cultures. Mycoplasma was isolated from 16.2 and 29.1 % of animals with and without respiratory signs, respectively. The high isolation rate of mycoplasmas in apparently healthy and clinically sick sheep and goats in this study indicates a carrier status in these SR which may constitute a serious problem in disease control.

Mycoplasma detection and isolation from one-humped camels (Camelus dromedarius).

PubMed

Mederos-Iriarte, Lidia E; Poveda, José B; Poveda, Carlos G; Vega-Orellana, Orestes M; Gutiérrez, Carlos; Corbera, Juan A; Ramírez, Ana S

2014-10-01

In scientific literature, a small amount of information is found concerning mycoplasmosis in camel species. Mycoplasma (M.) arginini, Acholeplasma (A.) laidlawii, and Acholeplasma oculi have been reported to be isolated from these host species. Serologically positive results have been reported for Mycoplasma mycoides subsp. mycoides SC type, Mycoplasma capricolum subsp. capripneumoniae, and M. mycoides subsp. capri. The aims of this study were to detect, isolate, and identify mycoplasmas from camels (Camelus dromedarius). Initially, saliva and ear smears plus conjunctival and vaginal secretions were taken from five female animals, but only conjunctival secretions in three male animals, all belonging to the same farm. An unknown mycoplasma was isolated from one of the vagina samples. Additionally, another unknown and uncultured mycoplasma was detected with molecular biology in the same sample. In the second stage, 23 vaginal secretions were taken from the same farm plus another secretion from a different one. Ten isolates of the same unknown and previously isolated mycoplasma were detected, nine of them recovered from the vagina of female camels. Some mycoplasmas have been related to reproductive disorders; however, there is no evidence that the isolated mycoplasmas are related to such disorders.

HSYMDOCK: a docking web server for predicting the structure of protein homo-oligomers with Cn or Dn symmetry.

PubMed

Yan, Yumeng; Tao, Huanyu; Huang, Sheng-You

2018-05-26

A major subclass of protein-protein interactions is formed by homo-oligomers with certain symmetry. Therefore, computational modeling of the symmetric protein complexes is important for understanding the molecular mechanism of related biological processes. Although several symmetric docking algorithms have been developed for Cn symmetry, few docking servers have been proposed for Dn symmetry. Here, we present HSYMDOCK, a web server of our hierarchical symmetric docking algorithm that supports both Cn and Dn symmetry. The HSYMDOCK server was extensively evaluated on three benchmarks of symmetric protein complexes, including the 20 CASP11-CAPRI30 homo-oligomer targets, the symmetric docking benchmark of 213 Cn targets and 35 Dn targets, and a nonredundant test set of 55 transmembrane proteins. It was shown that HSYMDOCK obtained a significantly better performance than other similar docking algorithms. The server supports both sequence and structure inputs for the monomer/subunit. Users have an option to provide the symmetry type of the complex, or the server can predict the symmetry type automatically. The docking process is fast and on average consumes 10∼20 min for a docking job. The HSYMDOCK web server is available at http://huanglab.phys.hust.edu.cn/hsymdock/.

Alteration of the Crust Beneath a Highland Crater

NASA Technical Reports Server (NTRS)

2007-01-01

This image of the wall of Capri Chasma, in Valles Marineris, was taken by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) at 1151 UTC (7:51 a.m. EDT) on October 6, 2007, near 12.03 degrees south latitude, 312.04 degrees east longitude. CRISM's image was taken in 544 colors covering 0.36-3.92 micrometers, and shows features as small as 20 meters (66 feet) across. The region covered is just over 10 kilometers (6.2 miles) wide at its narrowest point, and is one of several dozen that CRISM has taken to search for exposed layering in the chasma walls.

Valles Marineris is a large canyon system that extends more than 4,000 kilometers (2,485 miles) covering nearly one-fifth of the planet's circumference. If it were located on Earth, Valles Marineris would stretch from the California coast to New England and hold a volume of water approximately equal to that held by the Mediterranean Sea. One of several chasmata that comprise Valles Marineris, Capri Chasma is located toward the eastern end of the larger system.

The upper left panel in the montage above reveals the location of the CRISM image on a mosaic taken by the Mars Odyssey spacecraft's Thermal Emission Imaging System (THEMIS). The CRISM data are centered on a resistant spur of material roughly 4 kilometers (2.5 miles) long, located below a crater whose floor was eroded away by the chasma's rim. The upper right panel reveals this spur in infrared false color. Bright streaks emanating downward from the ridge indicate mass wasting of the lighter material that caps the spur.

The lower two images are renderings of data draped over topography without vertical exaggeration. These images provide a view of the spur's elevation relative to the surrounding terrain - the lower right in infrared false color, the lower left in false color to reveal mineral content. The predominantly blue color of the lower left image shows that the chasma wall rock is rich in pyroxene, a major constituent of basaltic rocks. The reds and greens in the resistant material that comprises the ridge indicate the presence of olivine and clay-like minerals called phyllosilicates. Broad swaths of red, yellow and green indicate mass wasting of this resistant material down the slope of the spur. Occurrence of phyllosilicate in the deep-seated wall rock provides evidence for a very ancient wet environment.

CRISM is one of six science instruments on NASA's Mars Reconnaissance Orbiter. Led by The Johns Hopkins University Applied Physics Laboratory, Laurel, Md., the CRISM team includes expertise from universities, government agencies and small businesses in the United States and abroad. NASA's Jet Propulsion Laboratory, a division of the California Institute of Technology in Pasadena, manages the Mars Reconnaissance Orbiter and the Mars Science Laboratory for NASA's Science Mission Directorate, Washington. Lockheed Martin Space Systems, Denver, built the orbiter.

Optimising The Available Scarce Water Resources At European Scale In A Modelling Environment: Results And Challenges

NASA Astrophysics Data System (ADS)

de Roo, Ad; Burek, Peter; Gentile, Alessandro; Udias, Angel; Bouraoui, Faycal

2013-04-01

As a next step to European drought monitoring and forecasting, which is covered in the European Drought Observatory (EDO) activity of JRC, a modeling environment has been developed to assess optimum measures to match water availability and water demand, while keeping ecological, water quality and flood risk aspects also into account. A multi-modelling environment has been developed to assess combinations of water retention measures, water savings measures, and nutrient reduction measures for continental Europe. These simulations have been carried out to assess the effects of those measures on several hydro-chemical indicators, such as the Water Exploitation Index, Environmental Flow indicators, low-flow frequency, N and P concentrations in rivers, the 50-year return period river discharge as an indicator for flooding, and economic losses due to water scarcity for the agricultural sector, the industrial sector, and the public sector. Also, potential flood damage of a 100-year return period flood has been used as an indicator. This modeling environment consists of linking the agricultural CAPRI model, the land use LUMP model, the water quantity LISFLOOD model, the water quality EPIC model, the combined water quantity/quality and hydro-economic LISQUAL model and a multi-criteria optimization routine. A python interface platform (IMO) has been built to link the different models. The work was carried out in the framework of a new European Commission policy document "Blueprint to Safeguard Europe's Water Resources", COM(2012)673), launched in November 2012. Simulations have been carried out to assess the effects of water retention measures, water savings measures, and nutrient reduction measures on several hydro-chemical indicators, such as the Water Exploitation Index, Environmental Flow indicators, N and P concentrations in rivers, the 50-year return period river discharge as an indicator for flooding, and economic losses due to water scarcity for the agricultural sector, the manufacturing-industry sector, the energy-production sector and the domestic sector. Also, potential flood damage of a 100-year return period flood has been used as an indicator. The study has shown that technically this modelling software environment can deliver optimum scenario combinations of packages of measures that improve various water quantity and water quality indicators, but that additional work is needed before final conclusions can be made using the tool. Further work is necessary, especially in the economic loss estimations, the water prices and price-elasticity, as well as the implementation and maintenance costs of individual scenarios. First results and challenges will be presented and discussed.

Modeling complexes of modeled proteins.

PubMed

Anishchenko, Ivan; Kundrotas, Petras J; Vakser, Ilya A

2017-03-01

Structural characterization of proteins is essential for understanding life processes at the molecular level. However, only a fraction of known proteins have experimentally determined structures. This fraction is even smaller for protein-protein complexes. Thus, structural modeling of protein-protein interactions (docking) primarily has to rely on modeled structures of the individual proteins, which typically are less accurate than the experimentally determined ones. Such "double" modeling is the Grand Challenge of structural reconstruction of the interactome. Yet it remains so far largely untested in a systematic way. We present a comprehensive validation of template-based and free docking on a set of 165 complexes, where each protein model has six levels of structural accuracy, from 1 to 6 Å C α RMSD. Many template-based docking predictions fall into acceptable quality category, according to the CAPRI criteria, even for highly inaccurate proteins (5-6 Å RMSD), although the number of such models (and, consequently, the docking success rate) drops significantly for models with RMSD > 4 Å. The results show that the existing docking methodologies can be successfully applied to protein models with a broad range of structural accuracy, and the template-based docking is much less sensitive to inaccuracies of protein models than the free docking. Proteins 2017; 85:470-478. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

New records of Lophoproctus coecus Pocock, 1894 (Diplopoda, Polyxenida, Lophoproctidae) extend the range of the genus Lophoproctus

PubMed Central

Short, Megan

2015-01-01

Abstract The geographic distribution of the genus Lophoproctus Pocock, 1894 has greatly expanded with new records of the species Lophoproctus coecus Pocock, 1894, together with the reassignment of a number of millipedes formerly identified as Lophoproctus lucidus (Chalande, 1888). Lophoproctus coecus was found to be the sole representative of the family Lophoproctidae in collections examined from Crimea and the Caucasian region. The species was also identified from Iran and Kyrgyzstan. Lophoproctus specimens collected in Italy by Verhoeff were reassigned as Lophoproctus coecus with the exception of one specimen of Lophoproctus jeanneli (Brölemann, 1910) from Capri. These data were combined with all available information from the literature to look at the pattern of distribution of the four species in the genus. The range of the genus Lophoproctus extends from Portugal to Central Asia. Lophoproctus coecus is widespread from Italy eastward, while the morphologically very similar species Lophoproctus lucidus is confined to France and northern Africa. The two species have a narrow overlap in the Alpes Maritimes region of France. Lophoproctus jeanneli has a scattered coastal distribution around the Mediterranean Sea. The troglobitic species Lophoproctus pagesi (Condé, 1982) has only been recorded from a cave on Majorca, Spain. PMID:26257544

PROCOS: computational analysis of protein-protein complexes.

PubMed

Fink, Florian; Hochrein, Jochen; Wolowski, Vincent; Merkl, Rainer; Gronwald, Wolfram

2011-09-01

One of the main challenges in protein-protein docking is a meaningful evaluation of the many putative solutions. Here we present a program (PROCOS) that calculates a probability-like measure to be native for a given complex. In contrast to scores often used for analyzing complex structures, the calculated probabilities offer the advantage of providing a fixed range of expected values. This will allow, in principle, the comparison of models corresponding to different targets that were solved with the same algorithm. Judgments are based on distributions of properties derived from a large database of native and false complexes. For complex analysis PROCOS uses these property distributions of native and false complexes together with a support vector machine (SVM). PROCOS was compared to the established scoring schemes of ZRANK and DFIRE. Employing a set of experimentally solved native complexes, high probability values above 50% were obtained for 90% of these structures. Next, the performance of PROCOS was tested on the 40 binary targets of the Dockground decoy set, on 14 targets of the RosettaDock decoy set and on 9 targets that participated in the CAPRI scoring evaluation. Again the advantage of using a probability-based scoring system becomes apparent and a reasonable number of near native complexes was found within the top ranked complexes. In conclusion, a novel fully automated method is presented that allows the reliable evaluation of protein-protein complexes. Copyright © 2011 Wiley Periodicals, Inc.

Large scale hydro-economic modelling for policy support

NASA Astrophysics Data System (ADS)

de Roo, Ad; Burek, Peter; Bouraoui, Faycal; Reynaud, Arnaud; Udias, Angel; Pistocchi, Alberto; Lanzanova, Denis; Trichakis, Ioannis; Beck, Hylke; Bernhard, Jeroen

2014-05-01

To support European Union water policy making and policy monitoring, a hydro-economic modelling environment has been developed to assess optimum combinations of water retention measures, water savings measures, and nutrient reduction measures for continental Europe. This modelling environment consists of linking the agricultural CAPRI model, the LUMP land use model, the LISFLOOD water quantity model, the EPIC water quality model, the LISQUAL combined water quantity, quality and hydro-economic model, and a multi-criteria optimisation routine. With this modelling environment, river basin scale simulations are carried out to assess the effects of water-retention measures, water-saving measures, and nutrient-reduction measures on several hydro-chemical indicators, such as the Water Exploitation Index (WEI), Nitrate and Phosphate concentrations in rivers, the 50-year return period river discharge as an indicator for flooding, and economic losses due to water scarcity for the agricultural sector, the manufacturing-industry sector, the energy-production sector and the domestic sector, as well as the economic loss due to flood damage. Recently, this model environment is being extended with a groundwater model to evaluate the effects of measures on the average groundwater table and available resources. Also, water allocation rules are addressed, while having environmental flow included as a minimum requirement for the environment. Economic functions are currently being updated as well. Recent development and examples will be shown and discussed, as well as open challenges.

InterPred: A pipeline to identify and model protein-protein interactions.

PubMed

Mirabello, Claudio; Wallner, Björn

2017-06-01

Protein-protein interactions (PPI) are crucial for protein function. There exist many techniques to identify PPIs experimentally, but to determine the interactions in molecular detail is still difficult and very time-consuming. The fact that the number of PPIs is vastly larger than the number of individual proteins makes it practically impossible to characterize all interactions experimentally. Computational approaches that can bridge this gap and predict PPIs and model the interactions in molecular detail are greatly needed. Here we present InterPred, a fully automated pipeline that predicts and model PPIs from sequence using structural modeling combined with massive structural comparisons and molecular docking. A key component of the method is the use of a novel random forest classifier that integrate several structural features to distinguish correct from incorrect protein-protein interaction models. We show that InterPred represents a major improvement in protein-protein interaction detection with a performance comparable or better than experimental high-throughput techniques. We also show that our full-atom protein-protein complex modeling pipeline performs better than state of the art protein docking methods on a standard benchmark set. In addition, InterPred was also one of the top predictors in the latest CAPRI37 experiment. InterPred source code can be downloaded from http://wallnerlab.org/InterPred Proteins 2017; 85:1159-1170. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications.

PubMed

Isidori, Andrea M; Graziadio, Chiara; Paragliola, Rosa Maria; Cozzolino, Alessia; Ambrogio, Alberto G; Colao, Annamaria; Corsello, Salvatore M; Pivonello, Rosario

2015-01-01

Cushing's syndrome is associated with increased mortality, mainly due to cardiovascular complications, which are sustained by the common development of systemic arterial hypertension and metabolic syndrome, which partially persist after the disease remission. Cardiovascular diseases and hypertension associated with endogenous hypercortisolism reveal underexplored peculiarities. The use of exogenous corticosteroids also impacts on hypertension and cardiovascular system, especially after prolonged treatment. The mechanisms involved in the development of hypertension differ, whether glucocorticoid excess is acute or chronic, and the source endogenous or exogenous, introducing inconsistencies among published studies. The pleiotropic effects of glucocorticoids and the overlap of the several regulatory mechanisms controlling blood pressure suggest that a rigorous comparison of in-vivo and in-vitro studies is necessary to draw reliable conclusions. This review, developed during the first 'Altogether to Beat Cushing's syndrome' workshop held in Capri in 2012, evaluates the most important peculiarities of hypertension associated with CS, with a particular focus on its pathophysiology. A critical appraisal of most significant animal and human studies is compared with a systematic review of the few available clinical trials. A special attention is dedicated to the description of the clinical features and cardiovascular damage secondary to glucocorticoid excess. On the basis of the consensus reached during the workshop, a pathophysiology-oriented therapeutic algorithm has been developed and it could serve as a first attempt to rationalize the treatment of hypertension in Cushing's syndrome.

Search for the viking 2 landing site.

PubMed

Masursky, H; Crabill, N L

1976-10-01

The search for the landing site of Viking 2 was more extensive than the search for the Viking 1 site. Seven times as much area (4.5 million square kilometers) was examined as for Viking 1. Cydonia (B1) and Capri (C1) sites were examined with the Viking 1 orbiter. The B latitude band (40 degrees to 50 degrees N) was selected before the final midcourse maneuver of Viking 2 because of its high scientific interest (that is, high atmospheric water content, surface temperature, possible near-surface permafrost, and a different geological domain). The Viking 1 orbiter continued photographing the Cydonia (B1) site to search for an area large and smooth enough on which to land (three-sigma ellipse; 100 by 260 kilometers); such an area was not found. The second spacecraft photographed and made infrared measurements in large areas in Arcadia (B2) and Utopia Planitia (B3). Both areas are highly textured, mottled cratered plains with abundant impact craters like Cydonia (B1), but smaller sectors in each area are partially mantled by wind-formed deposits. The thermal inertia, from which the grain size of surface material can be computed, and atmospheric water content were determined from the infrared observations. A region in Utopia Planitia, west of the crater Mie, was selected: the landing took place successfully on 3 September 1976 at 3:58:20 p.m. Pacific Daylight Time, earth received time.

Search for the Viking 2 landing site

USGS Publications Warehouse

Masursky, H.; Crabill, N.L.

1976-01-01

The search for the landing site of Viking 2 was more extensive than the search for the Viking 1 site. Seven times as much area (4.5 million square kilometers) was examined as for Viking 1. Cydonia (B1) and Capri (C1) sites were examined with the Viking 1 orbiter. The B latitude band (40?? to 50??N) was selected before the final midcourse maneuver of Viking 2 because of its high scientific interest (that is, high atmospheric water content, surface temperature, possible near-surface permafrost, and a different geological domain). The Viking 1 orbiter continued photographing the Cydonia (B1) site to search for an area large and smooth enough on which to land (three-sigma ellipse; 100 by 260 kilometers); such an area was not found. The second spacecraft photographed and made infrared measurements in large areas in Arcadia (B2) and Utopia Planitia (B3). Both areas are highly textured, mottled cratered plains with abundant impact craters like Cydonia (B1), but smaller sectors in each area are partially mantled by wind-formed deposits. The thermal inertia, from which the grain size of surface material can be computed, and atmospheric water content were determined from the infrared observations. A region in Utopia Planitia, west of the crater Mie, was selected: the landing took place successfully on 3 September 1976 at 3:58:20 p.m. Pacific Daylight Time, earth received time.

The pepATTRACT web server for blind, large-scale peptide-protein docking.

PubMed

de Vries, Sjoerd J; Rey, Julien; Schindler, Christina E M; Zacharias, Martin; Tuffery, Pierre

2017-07-03

Peptide-protein interactions are ubiquitous in the cell and form an important part of the interactome. Computational docking methods can complement experimental characterization of these complexes, but current protocols are not applicable on the proteome scale. pepATTRACT is a novel docking protocol that is fully blind, i.e. it does not require any information about the binding site. In various stages of its development, pepATTRACT has participated in CAPRI, making successful predictions for five out of seven protein-peptide targets. Its performance is similar or better than state-of-the-art local docking protocols that do require binding site information. Here we present a novel web server that carries out the rigid-body stage of pepATTRACT. On the peptiDB benchmark, the web server generates a correct model in the top 50 in 34% of the cases. Compared to the full pepATTRACT protocol, this leads to some loss of performance, but the computation time is reduced from ∼18 h to ∼10 min. Combined with the fact that it is fully blind, this makes the web server well-suited for large-scale in silico protein-peptide docking experiments. The rigid-body pepATTRACT server is freely available at http://bioserv.rpbs.univ-paris-diderot.fr/services/pepATTRACT. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

A computable phenotype for asthma case identification in adult and pediatric patients: External validation in the Chicago Area Patient-Outcomes Research Network (CAPriCORN).

PubMed

Afshar, Majid; Press, Valerie G; Robison, Rachel G; Kho, Abel N; Bandi, Sindhura; Biswas, Ashvini; Avila, Pedro C; Kumar, Harsha Vardhan Madan; Yu, Byung; Naureckas, Edward T; Nyenhuis, Sharmilee M; Codispoti, Christopher D

2017-10-13

Comprehensive, rapid, and accurate identification of patients with asthma for clinical care and engagement in research efforts is needed. The original development and validation of a computable phenotype for asthma case identification occurred at a single institution in Chicago and demonstrated excellent test characteristics. However, its application in a diverse payer mix, across different health systems and multiple electronic health record vendors, and in both children and adults was not examined. The objective of this study is to externally validate the computable phenotype across diverse Chicago institutions to accurately identify pediatric and adult patients with asthma. A cohort of 900 asthma and control patients was identified from the electronic health record between January 1, 2012 and November 30, 2014. Two physicians at each site independently reviewed the patient chart to annotate cases. The inter-observer reliability between the physician reviewers had a κ-coefficient of 0.95 (95% CI 0.93-0.97). The accuracy, sensitivity, specificity, negative predictive value, and positive predictive value of the computable phenotype were all above 94% in the full cohort. The excellent positive and negative predictive values in this multi-center external validation study establish a useful tool to identify asthma cases in in the electronic health record for research and care. This computable phenotype could be used in large-scale comparative-effectiveness trials.

7 CFR 3052.515 - Audit working papers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Audit working papers. 3052.515 Section 3052.515....515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and... the parties contesting the audit finding for guidance prior to destruction of the working papers and...

29 CFR 99.515 - Audit working papers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 1 2011-07-01 2011-07-01 false Audit working papers. 99.515 Section 99.515 Labor Office of....515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and... the parties contesting the audit finding for guidance prior to destruction of the working papers and...

Developing a Serious Game for decision making for the water-land-food-energy-climate Nexus in Sardinia-Italy: The SIM4NEXUS approach

NASA Astrophysics Data System (ADS)

Vamvakeridou-Lyroudia, Lydia; Alexandri, Eva; Blanco, Maria; Chew, Chengzi; Conradt, Tobias; Daskalou, Olympia; Evans, Barry; Guitart, Francesc; Mereu, Simone; Sartori, Martina; Susnik, Janez; Savic, Dragan

2017-04-01

A four-year EU H2020 project "Sustainable Integrated Management FOR the NEXUS of water-land-food-energy-climate for a resource-efficient Europe (SIM4NEXUS)" started in June 2016, with an overall grant of € 7.9M (www.sim4nexus.eu). The project involves 25 partners from 15 European countries. SIM4NEXUS has four objectives: (i) to adopt existing knowledge and develop new expertise on the water-energy-food-climate-land use Nexus; (ii) to reduce uncertainties of how policies, governance and institutions affect complex environmental systems; (iii) to showcase the implementation via a network of three regional, five national, two transboundary case studies in Europe, as well as continental and global studies; (iv) to valorise the project outputs by suitable business models. SIM4NEXUS develops an innovative concept and methodologies to facilitate the design of policies and bridge knowledge and technology gaps in the field of the Nexus under global change. The project will develop a methodology of integration using a complexity science approach and a Serious Game (a decision-based platform that allows policy makers to play out scenarios to see what would bring the best outcome) as an integrating tool for testing and evaluating policy decisions. The Serious Game is based on Aqua Republica (http://www.dhigroup.com/upload/publications/scribd/172629015-Exploring-the-World-of-Aqua-Republica-DHI-Case-Story.pdf ) and will cover a vast array of scenarios for all the case studies, over short, medium and long terms. In this presentation we focus on all the stages of the development of the Serious Game for one of our Case Studies (Sardinia, Italy) which is being used as a pilot example prior to wider rollout. Specifically we detail the components and steps involved in Game development including: (i) linking thematic models (CAPRI- http://www.capri-model.org/dokuwiki/doku.php and E3ME- http://www.e3me.com/) and downscaling to regional level; (ii) climate change scenarios (using and downscaling HADGEM2 models - http://www.metoffice.gov.uk/research/modelling-systems/unified-model/climate-models/hadgem2); (iii) socio-economic inputs and projections (GTAP - http://en.openei.org/wiki/Global_Trade_and_Analysis_Project_(GTAP)_Model) with System Dynamic Modelling (SDM) using STELLA for the visual environment- http://www.iseesystems.com/store/products/stella-professional.aspx and STELLAR as an open source programming language - http://www.r-gis.net/stellar/); (iv) creating a Knowledge Elicitation Engine (KEE), providing nexus semantics to the outputs of the SDM and (v) generating knowledge from Serious Game user interaction. Local data from Sardinian experts and stakeholders are being used in the pilot, which has been developed with their participation. The presentation will show results from sample scenarios and the approach to simulating uncertainties using SDM, as well as the overall data transfer and management scheme. It should be pointed out that the process of linking thematic models to System Dynamics (Complexity Science Modelling) and creating a KEE out of this combination is, to the best of our knowledge, novel and does not exist in the literature.

38 CFR 41.515 - Audit working papers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Audit working papers. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and reports for a minimum of...

Evidence for ponding and catastrophic floods in central Valles Marineris, Mars

USGS Publications Warehouse

Harrison, K.P.; Chapman, M.G.

2008-01-01

The Valles Marineris canyon system of Mars is closely related to large flood channels, some of which emerge full born from chaotic terrain in canyon floors. Coprates Chasma, one of the largest Valles Marineris canyons, is connected at its west end to Melas Chasma and on its east end to chaotic terrain-filled Capri and Eos Chasmata. The area from central Melas to Eos Chasmata contains a 1500 km long and about 1 km deep depression in its floor. Despite the large volumes of groundwater that likely discharged from chaotic terrain in this depression, no evidence of related fluvial activity has thus far been reported. We present an analysis of the regional topography which, together with photogeologic interpretation of available imagery, suggests that ponding due to late Hesperian discharge of water possibly produced a lake (mean depth 842 m) spanning parts of the Valles Marineris depression (VMD). Overflow of this lake at its eastern end resulted in delivery of water to downstream chaos regions and outflow channels. Our ponding hypothesis is motivated primarily by the identification of scarp and terrace features which, despite a lateral spread of about 1500 km, have similar elevations. Furthermore, these elevations correspond to the maximum ponding elevation of the region (-3560 m). Simulated ponding in the VMD yields an overflow point at its eastern extremity, in Eos Chasma. The neighborhood of this overflow point contains clear indicators of fluvial erosion in a consistent east-west orientation. ?? 2008 Elsevier Inc.

Cryo-EM Data Are Superior to Contact and Interface Information in Integrative Modeling.

PubMed

de Vries, Sjoerd J; Chauvot de Beauchêne, Isaure; Schindler, Christina E M; Zacharias, Martin

2016-02-23

Protein-protein interactions carry out a large variety of essential cellular processes. Cryo-electron microscopy (cryo-EM) is a powerful technique for the modeling of protein-protein interactions at a wide range of resolutions, and recent developments have caused a revolution in the field. At low resolution, cryo-EM maps can drive integrative modeling of the interaction, assembling existing structures into the map. Other experimental techniques can provide information on the interface or on the contacts between the monomers in the complex. This inevitably raises the question regarding which type of data is best suited to drive integrative modeling approaches. Systematic comparison of the prediction accuracy and specificity of the different integrative modeling paradigms is unavailable to date. Here, we compare EM-driven, interface-driven, and contact-driven integrative modeling paradigms. Models were generated for the protein docking benchmark using the ATTRACT docking engine and evaluated using the CAPRI two-star criterion. At 20 Å resolution, EM-driven modeling achieved a success rate of 100%, outperforming the other paradigms even with perfect interface and contact information. Therefore, even very low resolution cryo-EM data is superior in predicting heterodimeric and heterotrimeric protein assemblies. Our study demonstrates that a force field is not necessary, cryo-EM data alone is sufficient to accurately guide the monomers into place. The resulting rigid models successfully identify regions of conformational change, opening up perspectives for targeted flexible remodeling. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Cyto-adherence of Mycoplasma mycoides subsp. mycoides to bovine lung epithelial cells.

PubMed

Aye, Racheal; Mwirigi, Martin Kiogora; Frey, Joachim; Pilo, Paola; Jores, Joerg; Naessens, Jan

2015-02-07

Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP), a respiratory disease of cattle, whereas the closely related Mycoplasma mycoides subsp. capri (Mmc) is a goat pathogen. Cyto-adherence is a crucial step in host colonization by mycoplasmas and subsequent pathogenesis. The aim of this study was to investigate the interactions between Mmm and mammalian host cells by establishing a cyto-adherence flow cytometric assay and comparing tissue and species specificity of Mmm and Mmc strains. There were little significant differences in the adherence patterns of eight different Mmm strains to adult bovine lung epithelial cells. However, there was statistically significant variation in binding to different host cells types. Highest binding was observed with lung epithelial cells, intermediate binding with endothelial cells and very low binding with fibroblasts, suggesting the presence of effective adherence of Mmm on cells lining the airways of the lung, which is the target organ for this pathogen, possibly by high expression of a specific receptor. However, binding to bovine fetal lung epithelial cells was comparably low; suggesting that the lack of severe pulmonary disease seen in many infected young calves can be explained by reduced expression of a specific receptor. Mmm bound with high efficiency to adult bovine lung cells and less efficiently to calves or goat lung cells. The data show that cyto-adherence of Mmm is species- and tissue- specific confirming its role in colonization of the target host and subsequent infection and development of CBPP.

The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications

PubMed Central

Isidori, Andrea M.; Graziadio, Chiara; Paragliola, Rosa Maria; Cozzolino, Alessia; Ambrogio, Alberto G.; Colao, Annamaria; Corsello, Salvatore M.; Pivonello, Rosario

2015-01-01

Cushing's syndrome is associated with increased mortality, mainly due to cardiovascular complications, which are sustained by the common development of systemic arterial hypertension and metabolic syndrome, which partially persist after the disease remission. Cardiovascular diseases and hypertension associated with endogenous hypercortisolism reveal underexplored peculiarities. The use of exogenous corticosteroids also impacts on hypertension and cardiovascular system, especially after prolonged treatment. The mechanisms involved in the development of hypertension differ, whether glucocorticoid excess is acute or chronic, and the source endogenous or exogenous, introducing inconsistencies among published studies. The pleiotropic effects of glucocorticoids and the overlap of the several regulatory mechanisms controlling blood pressure suggest that a rigorous comparison of in-vivo and in-vitro studies is necessary to draw reliable conclusions. This review, developed during the first ‘Altogether to Beat Cushing's syndrome’ workshop held in Capri in 2012, evaluates the most important peculiarities of hypertension associated with CS, with a particular focus on its pathophysiology. A critical appraisal of most significant animal and human studies is compared with a systematic review of the few available clinical trials. A special attention is dedicated to the description of the clinical features and cardiovascular damage secondary to glucocorticoid excess. On the basis of the consensus reached during the workshop, a pathophysiology-oriented therapeutic algorithm has been developed and it could serve as a first attempt to rationalize the treatment of hypertension in Cushing's syndrome. PMID:25415766

Cryo-EM Data Are Superior to Contact and Interface Information in Integrative Modeling

PubMed Central

de Vries, Sjoerd J.; Chauvot de Beauchêne, Isaure; Schindler, Christina E.M.; Zacharias, Martin

2016-01-01

Protein-protein interactions carry out a large variety of essential cellular processes. Cryo-electron microscopy (cryo-EM) is a powerful technique for the modeling of protein-protein interactions at a wide range of resolutions, and recent developments have caused a revolution in the field. At low resolution, cryo-EM maps can drive integrative modeling of the interaction, assembling existing structures into the map. Other experimental techniques can provide information on the interface or on the contacts between the monomers in the complex. This inevitably raises the question regarding which type of data is best suited to drive integrative modeling approaches. Systematic comparison of the prediction accuracy and specificity of the different integrative modeling paradigms is unavailable to date. Here, we compare EM-driven, interface-driven, and contact-driven integrative modeling paradigms. Models were generated for the protein docking benchmark using the ATTRACT docking engine and evaluated using the CAPRI two-star criterion. At 20 Å resolution, EM-driven modeling achieved a success rate of 100%, outperforming the other paradigms even with perfect interface and contact information. Therefore, even very low resolution cryo-EM data is superior in predicting heterodimeric and heterotrimeric protein assemblies. Our study demonstrates that a force field is not necessary, cryo-EM data alone is sufficient to accurately guide the monomers into place. The resulting rigid models successfully identify regions of conformational change, opening up perspectives for targeted flexible remodeling. PMID:26846888

7 CFR 3052.515 - Audit working papers.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 3052.515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and reports for a minimum of three years after the date of issuance of the auditor's report(s) to the auditee...

38 CFR 41.515 - Audit working papers.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and reports for a minimum of three years after the date of issuance of the auditor's report(s) to the auditee, unless the auditor is...

29 CFR 99.515 - Audit working papers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 99.515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and reports for a minimum of three years after the date of issuance of the auditor's report(s) to the auditee...

Seminar on Cataloguing (1970): Working Paper and Proceedings.

ERIC Educational Resources Information Center

Documentation Research and Training Centre, Bangalore (India).

The publication includes papers from the opening session, eighteen working papers on library cataloging, eighteen papers presented at group meetings and plenary sessions, and papers from the concluding session. The inaugural address "Cataloging Enters the Spiral of Scientific Method" was presented by S.R. Ranganathan. The working paper…

Protein Models Docking Benchmark 2

PubMed Central

Anishchenko, Ivan; Kundrotas, Petras J.; Tuzikov, Alexander V.; Vakser, Ilya A.

2015-01-01

Structural characterization of protein-protein interactions is essential for our ability to understand life processes. However, only a fraction of known proteins have experimentally determined structures. Such structures provide templates for modeling of a large part of the proteome, where individual proteins can be docked by template-free or template-based techniques. Still, the sensitivity of the docking methods to the inherent inaccuracies of protein models, as opposed to the experimentally determined high-resolution structures, remains largely untested, primarily due to the absence of appropriate benchmark set(s). Structures in such a set should have pre-defined inaccuracy levels and, at the same time, resemble actual protein models in terms of structural motifs/packing. The set should also be large enough to ensure statistical reliability of the benchmarking results. We present a major update of the previously developed benchmark set of protein models. For each interactor, six models were generated with the model-to-native Cα RMSD in the 1 to 6 Å range. The models in the set were generated by a new approach, which corresponds to the actual modeling of new protein structures in the “real case scenario,” as opposed to the previous set, where a significant number of structures were model-like only. In addition, the larger number of complexes (165 vs. 63 in the previous set) increases the statistical reliability of the benchmarking. We estimated the highest accuracy of the predicted complexes (according to CAPRI criteria), which can be attained using the benchmark structures. The set is available at http://dockground.bioinformatics.ku.edu. PMID:25712716

78 FR 68501 - International Standards on the Transport of Dangerous Goods

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-14

... include: Review of Working papers Working Group updates Regulatory Cooperation Council (RCC) Update... sessions, can be found on the United Nations Economic Commission for Europe (UNECE) Transport Division Web... its decisions on Working Papers. The Working Papers for the 26th session of the UNSCEGHS are located...

Tracking the follow-up of work in progress papers.

PubMed

Mubin, Omar; Arsalan, Mudassar; Al Mahmud, Abdullah

2018-01-01

Academic conferences offer numerous submission tracks to support the inclusion of a variety of researchers and topics. Work in progress papers are one such submission type where authors present preliminary results in a poster session. They have recently gained popularity in the area of Human Computer Interaction (HCI) as a relatively easier pathway to attending the conference due to their higher acceptance rate as compared to the main tracks. However, it is not clear if these work in progress papers are further extended or transitioned into more complete and thorough full papers or are simply one-off pieces of research. In order to answer this we explore self-citation patterns of four work in progress editions in two popular HCI conferences (CHI2010, CHI2011, HRI2010 and HRI2011). Our results show that almost 50% of the work in progress papers do not have any self-citations and approximately only half of the self-citations can be considered as true extensions of the original work in progress paper. Specific conferences dominate as the preferred venue where extensions of these work in progress papers are published. Furthermore, the rate of self-citations peaks in the immediate year after publication and gradually tails off. By tracing author publication records, we also delve into possible reasons of work in progress papers not being cited in follow up publications. In conclusion, we speculate on the main trends observed and what they may mean looking ahead for the work in progress track of premier HCI conferences.

Satellite-Distributed Educational Television For Developing Countries; Working Papers. Volume 4.

ERIC Educational Resources Information Center

Schramm, Wilbur; And Others

This volume contains a collection of working papers designed to accompany the case studies of India and Latin America in providing a framework for the planning of educational broadcasting systems. The first two papers offer useful orientation to policy-makers who are considering educational television. Working Paper No. 3 compares the two media of…

Measuring Instruction, Curriculum Content, and Instructional Resources: The Status of Recent Work. Working Paper Series.

ERIC Educational Resources Information Center

Leighton, Mary S.; Mullens, John E.; Turnbull, Brenda; Weiner, Lisa K.; Williams, Angela S.

The four papers in this volume are four parts of a series on the status of recent work on measuring instruction, curriculum content, and instructional resources. These papers are intended to identify aspects of instruction, to analyze the approaches used in several leading studies, and to describe the implications of recent work for National…

32 CFR 2001.24 - Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Foreign Nuclear Information (TFNI). (1) As permitted under 42 U.S.C. 2162(e), the Department of Energy.... (d) Working papers. A working paper is defined as documents or materials, regardless of the media... retention. Working papers containing classified information shall be dated when created, marked with the...

32 CFR 2001.24 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Foreign Nuclear Information (TFNI). (1) As permitted under 42 U.S.C. 2162(e), the Department of Energy.... (d) Working papers. A working paper is defined as documents or materials, regardless of the media... retention. Working papers containing classified information shall be dated when created, marked with the...

32 CFR 2001.24 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Foreign Nuclear Information (TFNI). (1) As permitted under 42 U.S.C. 2162(e), the Department of Energy.... (d) Working papers. A working paper is defined as documents or materials, regardless of the media... retention. Working papers containing classified information shall be dated when created, marked with the...

32 CFR 2001.24 - Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Foreign Nuclear Information (TFNI). (1) As permitted under 42 U.S.C. 2162(e), the Department of Energy.... (d) Working papers. A working paper is defined as documents or materials, regardless of the media... retention. Working papers containing classified information shall be dated when created, marked with the...

San Francisco Bay Area 1990 Regional Travel Characteristics, Working Paper #4: 1990 MTC Travel Survey

DOT National Transportation Integrated Search

1994-12-01

This working paper is the fourth in a series to document analysis and results : from the 1990 MTC household travel survey. Previous working papers on the 1990 : travel survey covered survey design issues, sample weighting and expansion, and : trip li...

Work, Family, and the Faculty Career. New Pathways: Faculty Career and Employment for the 21st Century Working Paper Series, Inquiry #8.

ERIC Educational Resources Information Center

Gappa, Judith M.; MacDermid, Shelley M.

This paper, one in a series about the priorities of the professoriate, examines work-family issues as they affect faculty recruitment, retention, and productivity. Following a brief discussion of changing work-force demographics, the first part of the paper examines the structure of an academic career, focusing particularly on junior faculty and…

Structural Interface Parameters Are Discriminatory in Recognising Near-Native Poses of Protein-Protein Interactions

PubMed Central

Malhotra, Sony; Sankar, Kannan; Sowdhamini, Ramanathan

2014-01-01

Interactions at the molecular level in the cellular environment play a very crucial role in maintaining the physiological functioning of the cell. These molecular interactions exist at varied levels viz. protein-protein interactions, protein-nucleic acid interactions or protein-small molecules interactions. Presently in the field, these interactions and their mechanisms mark intensively studied areas. Molecular interactions can also be studied computationally using the approach named as Molecular Docking. Molecular docking employs search algorithms to predict the possible conformations for interacting partners and then calculates interaction energies. However, docking proposes number of solutions as different docked poses and hence offers a serious challenge to identify the native (or near native) structures from the pool of these docked poses. Here, we propose a rigorous scoring scheme called DockScore which can be used to rank the docked poses and identify the best docked pose out of many as proposed by docking algorithm employed. The scoring identifies the optimal interactions between the two protein partners utilising various features of the putative interface like area, short contacts, conservation, spatial clustering and the presence of positively charged and hydrophobic residues. DockScore was first trained on a set of 30 protein-protein complexes to determine the weights for different parameters. Subsequently, we tested the scoring scheme on 30 different protein-protein complexes and native or near-native structure were assigned the top rank from a pool of docked poses in 26 of the tested cases. We tested the ability of DockScore to discriminate likely dimer interactions that differ substantially within a homologous family and also demonstrate that DOCKSCORE can distinguish correct pose for all 10 recent CAPRI targets. PMID:24498255

Structural interface parameters are discriminatory in recognising near-native poses of protein-protein interactions.

PubMed

Malhotra, Sony; Sankar, Kannan; Sowdhamini, Ramanathan

2014-01-01

Interactions at the molecular level in the cellular environment play a very crucial role in maintaining the physiological functioning of the cell. These molecular interactions exist at varied levels viz. protein-protein interactions, protein-nucleic acid interactions or protein-small molecules interactions. Presently in the field, these interactions and their mechanisms mark intensively studied areas. Molecular interactions can also be studied computationally using the approach named as Molecular Docking. Molecular docking employs search algorithms to predict the possible conformations for interacting partners and then calculates interaction energies. However, docking proposes number of solutions as different docked poses and hence offers a serious challenge to identify the native (or near native) structures from the pool of these docked poses. Here, we propose a rigorous scoring scheme called DockScore which can be used to rank the docked poses and identify the best docked pose out of many as proposed by docking algorithm employed. The scoring identifies the optimal interactions between the two protein partners utilising various features of the putative interface like area, short contacts, conservation, spatial clustering and the presence of positively charged and hydrophobic residues. DockScore was first trained on a set of 30 protein-protein complexes to determine the weights for different parameters. Subsequently, we tested the scoring scheme on 30 different protein-protein complexes and native or near-native structure were assigned the top rank from a pool of docked poses in 26 of the tested cases. We tested the ability of DockScore to discriminate likely dimer interactions that differ substantially within a homologous family and also demonstrate that DOCKSCORE can distinguish correct pose for all 10 recent CAPRI targets.

Incidence and causes of new-onset dyspnea in 3,719 patients treated with clopidogrel and aspirin combination after coronary stenting.

PubMed

Serebruany, Victor; Pokov, Ilya; Kuliczkowski, Wiktor; Vahabi, Javad; Atar, Dan

2008-08-01

The experimental oral antiplatelet agent AZD6140 causes dyspnea in randomized trials. Whether clopidogrel may also cause dyspnea remains controversial. We sought to define the incidence and causes of dyspnea in a large post-percutaneous coronary intervention (PCI) cohort based on open-labeled consecutive registry analysis of in-hospital charts and discharge diagnoses. Data were collected at six-month follow-up by means of telephone interviews or returned questionnaires during outpatient visits. Patients undergoing coronary stent implantation were loaded with 600 mg clopidogrel followed by 75 mg/daily in combination with 75-325 mg of aspirin daily for at least six months. Data from 3,719 patients were analyzed. Dyspnea was diagnosed in 157 (4.2%) patients caused by chronic obstructive pulmonary disease (n = 43 or 27% of the dyspnea group), heart failure (n = 30 or 19%), cancer (n = 22 or 14%), pneumonia (n = 17 or 11%); asthma (n = 8 or 5%), pulmonary hypertension (n = 8 or 5%); pericarditis (n = 5 or 3%); cardiac arrhythmias (n = 4 or 2.5%); pleural effusion (n = 1), pulmonary embolism (n = 1), anxiety (n = 1), or unknown (n = 17, or 11%). The incidence of dyspnea at six months in a post-stent cohort treated with aspirin and clopidogrel is low (4.2%). The majority of patients with dyspnea (140/157) exhibit a distinct underlying disease or condition, in contrast to only 17 patients (0.45% of total cohort) in whom the pathogenesis of dyspnea remained unidentified. These data closely match the frequency of dyspnea that was observed in the CAPRIE trial, suggesting that therapy with clopidogrel, and/or aspirin holds very small (if any) risk for dyspnea.

Using Shaun Tan's Work to Foster Multiliteracies in 21st-Century Classrooms

ERIC Educational Resources Information Center

Dallacqua, Ashley K.; Kersten, Sara; Rhoades, Mindi

2015-01-01

This paper explores work in multimodality and design as it relates to 21st century multiliteracies. After outlining the concept of a multiliteracies pedagogy, this paper describes multimodality and multimodal texts. Moving from the theoretical to the practical, this paper primarily explores selected multimodal works of Shaun Tan and the…

Intelligent transportation system (ITS) study for the Buffalo and Niagara Falls metropolitan area, Erie and Niagara Counties, New York : strategic plan, working paper #7

DOT National Transportation Integrated Search

1997-06-18

This document has been prepared as part of the New York State Department of Transportation (NYSDOT) Buffalo and Niagara Falls Intelligent Transportation System Study. This working paper utilizes input from the previous working papers to generate an o...

The Characteristics of Faculty in Comprehensive Institutions: New England Comprehensive Universities Academic Labor Market Study. Working Paper #10.

ERIC Educational Resources Information Center

Youn, Ted I. K.

This paper compares the characteristics of faculty in comprehensive institutions of higher education with those of faculty in other college and university categories. The paper summarizes demographic features, working conditions, satisfaction and participation in academic work organizations, mobility and careers, and attitudes and orientations…

Working Papers in Art Education, 1989-1990.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1990-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this double volume the works are organized by sponsoring university. Student papers presented are: (1) "Looking, Talking, and Experiencing Art with Preschoolers" (Shari…

Working Papers in Art Education, 1991.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1991-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by sponsoring university. Student papers presented are: (1) "Interpreting Museums as Cultural Metaphors" (Michael Sikes); (2) "Key…

Social Work Learning Spaces: The Social Work Studio

ERIC Educational Resources Information Center

Zufferey, Carole; King, Sue

2016-01-01

This paper explores the contribution of a physical learning space to student engagement in social work education. Drawing on a constructivist methodology, this paper examines the findings of a survey conducted with students and staff in a social work and human service programme about their experiences of a Social Work Studio learning space. The…

Programs for Middle School Math: An Inventory of Existing Technology. Working Paper

ERIC Educational Resources Information Center

Saultz, Andrew

2012-01-01

In this working paper, Andrew Saultz of Michigan State University inventories the current landscape of technology programs available for middle school math. The working paper is not intended as a "consumers' guide" to technology programs, and the descriptions of some specific programs are not fully accurate or current. Readers who are interested…

Project-Based Learning: A Literature Review. Working Paper

ERIC Educational Resources Information Center

Condliffe, Barbara

2017-01-01

The concept of project-based learning (PBL) has garnered wide support among a number of K-12 education policy advocates and funders. This working paper builds on and updates a seminal literature review of PBL published in 2000. Focused primarily on articles and studies that have emerged in the 17 years since then, the working paper discusses the…

Basic Skills Instruction in Community Colleges: The Dominance of Remedial Pedagogy. Working Paper, Number 2

ERIC Educational Resources Information Center

Grubb, W. Norton; Boner, Elizabeth; Frankel, Kate; Parker, Lynette; Patterson, David; Gabriner, Robert; Hope, Laura; Schiorring, Eva; Smith, Bruce; Taylor, Richard; Walton, Ian; Wilson, Smokey

2011-01-01

A previous working paper argued, that, to understand basic skills education, it is necessary to observe classrooms to see what the "instructional triangle" involving the instructor, students, and content is like. This working paper presents the results of observing classes in 13 community colleges. It starts with a conceptualization of…

Improving the Health of Working Families: Research Connections Between Work and Health. NPA Report.

ERIC Educational Resources Information Center

Yen, Irene H.; Frank, John W.

This document contains two papers on connections between work and health and policy options for improving the health of working families. "Foreword" (James A. Auerbach) places the two papers in the context of recent research on the connections between work, family, and health. Chapter 1's overview addresses the changing nature of work,…

76 FR 80970 - Records Schedules; Availability and Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... studies working groups and other senior bodies, and substantive working papers. 11. Office of the Director... external web page material, and non-substantive working papers and drafts. Proposed for permanent retention... correspondence, staff-level working groups and committees, advisory program background information, non...

Artifice, Interpretation and Nature: Key Categories in Radiology Work

NASA Astrophysics Data System (ADS)

Nyce, James M.

This paper extends on some prior work on nature, culture and computation. This paper will look at “image work” in a radiology department, i.e, how radiologists use images and other kinds of knowledge in daily clinical work. In particular, the paper will look at the role tacit knowledge and categories have in the work radiologists carry out. How radiologists make use of and contrast analog and digital representations of nature will be explored here because this is key to how radiologists work and think. In other words, the role that computer derived artifacts, correspondence theory and mimesis play in the clinical work of radiology will be discussed.

Working Papers in Art Education, 1988.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1988-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by sponsoring university. Student papers presented are: (1) "A Naturalistic Study of Art Choices in a Preschool Setting" (Karen Thomas);…

Working Papers in Art Education, 1992.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1992-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by the sponsoring university. Student papers presented are: (1) "How Will Moy, Chantale, Susan and Lola Make It through Art School?" (Miriam…

Working Papers in Art Education, 1994-1995.

ERIC Educational Resources Information Center

Thunder-McGuire, Steve, Ed.

1996-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by the sponsoring university. Student papers presented are: (1) "Looking at Feminist Pedagogies: What is Seen in the Literature and What is…

Disability, Work and Cash Benefits.

ERIC Educational Resources Information Center

Mashaw, Jerry L., Ed.; And Others

This book contains 13 papers from a workshop convened to explore the causes of work disability and the types of interventions that might enable individuals to remain at work, return to work, or enter the work force for the first time, despite having chronic health conditions or impairments. Following an overview of the papers by editors Jerry L.…

Higher Education's Responsiveness in Mexico and the United States to a New Economy and the Impacts of NAFTA. "Understanding the Differences": A Working Paper Series on Higher Education in the U.S. and Mexico. Working Paper Number 4.

ERIC Educational Resources Information Center

Santillanez, Elizabeth J.

This working paper discusses the critical role that higher education in the United States and Mexico must play since the implementation of the North American Free Trade Agreement (NAFTA). The paper gives an overview of recent transformations in areas of economic development and business needs which require that higher education better prepare…

Gendered Violence: Examining Education's Role. Working Paper Series. Working Paper 4.

ERIC Educational Resources Information Center

Hanson, Katherine

Violence is a part of daily life in the United States, the world's leader in the number of homicides, rapes, and assaults. This working paper examines the issue of violence in the United States from a gender equity perspective. Gendered violence is reinforced by cultural beliefs that allow individuals and groups to use violence to establish and…

USL/DBMS NASA/RECON working paper series. Standards

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Chum, Frank Y.

1984-01-01

The USL/DBMS NASA/RECON Working Paper Series contains a collection of reports representing results of activities being conducted by the Computer Science Department of the University of Southwestern Louisiana pursuant to the specifications of NASA Contract number NASw-3846. The work on this portion of the contract is being performed jointly by the University of Southwestern Louisiana and Southern University. This report contains the full set of standards for the development, formatting, reviewing, and issuance of entries within the USL/DBMS NASA/RECON Working Paper Series.

Council of Ontario Universities Working Paper Series, 2001-2002.

ERIC Educational Resources Information Center

Forcese, Dennis; Oosthuizen, Patrick; Aubrey, Jocelyn B.

2002-01-01

Papers in this volume are the first working papers produced by the Council of Ontario Universities. Issue 1, "The Role and State of Ontario Graduate Education" by Dennis Forcese, advocates the reinforcement of graduate education in Ontario institutions to maintain the overall quality of the institutions and to secure the future. The paper outlines…

Work and the Quality of Life: Resource Papers for Work in America.

ERIC Educational Resources Information Center

O'Toole, James, Ed.

A sequel to Work in America, the volume of resource papers provides additional data on issues concerning the relationships of work to health, education, and welfare. The report is a planning document which focuses on how the institution of work can be changed to improve the quality of life, to contribute to a more just society, and to strengthen…

Adult Education and Work. Papers Presented at the Seminar on Adult Education and Work (Hamburg, Germany, November 30-December 1, 1990).

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Hamburg (Germany). Inst. for Education.

This report contains an introduction and six presentations from a seminar on adult education and work. The introduction by Paul Belanger and four of the papers are in French; the other two are in English. The papers are "The Expansion of Adult Education and Training in Europe: Trends, Explanations, and Challenges" (Albert Tuijnman);…

A Geometry Based Infra-Structure for Computational Analysis and Design

NASA Technical Reports Server (NTRS)

Haimes, Robert

1998-01-01

The computational steps traditionally taken for most engineering analysis suites (computational fluid dynamics (CFD), structural analysis, heat transfer and etc.) are: (1) Surface Generation -- usually by employing a Computer Assisted Design (CAD) system; (2) Grid Generation -- preparing the volume for the simulation; (3) Flow Solver -- producing the results at the specified operational point; (4) Post-processing Visualization -- interactively attempting to understand the results. For structural analysis, integrated systems can be obtained from a number of commercial vendors. These vendors couple directly to a number of CAD systems and are executed from within the CAD Graphical User Interface (GUI). It should be noted that the structural analysis problem is more tractable than CFD; there are fewer mesh topologies used and the grids are not as fine (this problem space does not have the length scaling issues of fluids). For CFD, these steps have worked well in the past for simple steady-state simulations at the expense of much user interaction. The data was transmitted between phases via files. In most cases, the output from a CAD system could go to Initial Graphics Exchange Specification (IGES) or Standard Exchange Program (STEP) files. The output from Grid Generators and Solvers do not really have standards though there are a couple of file formats that can be used for a subset of the gridding (i.e. PLOT3D data formats). The user would have to patch up the data or translate from one format to another to move to the next step. Sometimes this could take days. Specifically the problems with this procedure are:(1) File based -- Information flows from one step to the next via data files with formats specified for that procedure. File standards, when they exist, are wholly inadequate. For example, geometry from CAD systems (transmitted via IGES files) is defined as disjoint surfaces and curves (as well as masses of other information of no interest for the Grid Generator). This is particularly onerous for modern CAD systems based on solid modeling. The part was a proper solid and in the translation to IGES has lost this important characteristic. STEP is another standard for CAD data that exists and supports the concept of a solid. The problem with STEP is that a solid modeling geometry kernel is required to query and manipulate the data within this type of file. (2) 'Good' Geometry. A bottleneck in getting results from a solver is the construction of proper geometry to be fed to the grid generator. With 'good' geometry a grid can be constructed in tens of minutes (even with a complex configuration) using unstructured techniques. Adroit multi-block methods are not far behind. This means that a million node steady-state solution can be computed on the order of hours (using current high performance computers) starting from this 'good' geometry. Unfortunately, the geometry usually transmitted from the CAD system is not 'good' in the grid generator sense. The grid generator needs smooth closed solid geometry. It can take a week (or more) of interaction with the CAD output (sometimes by hand) before the process can begin. One way Communication. (3) One-way Communication -- All information travels on from one phase to the next. This makes procedures like node adaptation difficult when attempting to add or move nodes that sit on bounding surfaces (when the actual surface data has been lost after the grid generation phase). Until this process can be automated, more complex problems such as multi-disciplinary analysis or using the above procedure for design becomes prohibitive. There is also no way to easily deal with this system in a modular manner. One can only replace the grid generator, for example, if the software reads and writes the same files. Instead of the serial approach to analysis as described above, CAPRI takes a geometry centric approach. This makes the actual geometry (not a discretized version) accessible to all phases of the analysis. The connection to the geometry is made through an Application Programming Interface (API) and NOT a file system. This API isolates the top-level applications (grid generators, solvers and visualization components) from the geometry engine. Also this allows the replacement of one geometry kernel with another, without effecting these top-level applications. For example, if UniGraphics is used as the CAD package then Parasolid (UG's own geometry engine) can be used for all geometric queries so that no solid geometry information is lost in a translation. This is much better than STEP because when the data is queried, the same software is executed as used in the CAD system. Therefore, one analyzes the exact part that is in the CAD system. CAPRI uses the same idea as the commercial structural analysis codes but does not specify control. Software components of the CAD system are used, but the analysis suite, not the CAD operator, specifies the control of the software session. This also means that the license issues (may be) minimized and individuals need not have to know how to operate a CAD system in order to run the suite.

Review on pen-and-paper-based observational methods for assessing ergonomic risk factors of computer work.

PubMed

Rahman, Mohd Nasrull Abdol; Mohamad, Siti Shafika

2017-01-01

Computer works are associated with Musculoskeletal Disorders (MSDs). There are several methods have been developed to assess computer work risk factor related to MSDs. This review aims to give an overview of current techniques available for pen-and-paper-based observational methods in assessing ergonomic risk factors of computer work. We searched an electronic database for materials from 1992 until 2015. The selected methods were focused on computer work, pen-and-paper observational methods, office risk factors and musculoskeletal disorders. This review was developed to assess the risk factors, reliability and validity of pen-and-paper observational method associated with computer work. Two evaluators independently carried out this review. Seven observational methods used to assess exposure to office risk factor for work-related musculoskeletal disorders were identified. The risk factors involved in current techniques of pen and paper based observational tools were postures, office components, force and repetition. From the seven methods, only five methods had been tested for reliability. They were proven to be reliable and were rated as moderate to good. For the validity testing, from seven methods only four methods were tested and the results are moderate. Many observational tools already exist, but no single tool appears to cover all of the risk factors including working posture, office component, force, repetition and office environment at office workstations and computer work. Although the most important factor in developing tool is proper validation of exposure assessment techniques, the existing observational method did not test reliability and validity. Futhermore, this review could provide the researchers with ways on how to improve the pen-and-paper-based observational method for assessing ergonomic risk factors of computer work.

Shortages in Professions Working with Young Children with Disabilities and Their Families.

ERIC Educational Resources Information Center

Hebbeler, Kathleen

This paper synthesizes information about shortages among the professions working with young children with disabilities, birth through age 5, and their families. The paper begins with a look at national data on personnel working in early intervention and preschool special education. Distinctions between the work force in early intervention (Part H…

Cognitive Tools and the Acquisition of Literacy. Working Paper No. 5

ERIC Educational Resources Information Center

Egan, Kieran

2001-01-01

This is the fifth paper published by The Centre for Literacy in its Working Papers on Literacy series, which presents new perspectives on literacy-related topics relevant to researchers, practitioners, and policy-makers. This paper was adapted from a longer manuscript submitted by Kieran Egan in 1999 for the UNESCO Award for Research in Adult…

Laboring Below the Line: The New Ethnography of Poverty, Low-Wage Work, and Survival in the Global Economy.

ERIC Educational Resources Information Center

Munger, Frank, Ed.

This document contains 15 papers on poverty, low-wage work, and survival in the global economy, with emphasis on the following topics: identity and the meaning of work; making decisions about work, family, and welfare; and paths toward change. The following papers are included: "Identity as a Weapon in the Moral Politics of Work and…

Do scientific advancements lean on the shoulders of giants? A bibliometric investigation of the Ortega hypothesis.

PubMed

Bornmann, Lutz; de Moya Anegón, Félix; Leydesdorff, Loet

2010-10-13

In contrast to Newton's well-known aphorism that he had been able "to see further only by standing on the shoulders of giants," one attributes to the Spanish philosopher Ortega y Gasset the hypothesis saying that top-level research cannot be successful without a mass of medium researchers on which the top rests comparable to an iceberg. The Ortega hypothesis predicts that highly-cited papers and medium-cited (or lowly-cited) papers would equally refer to papers with a medium impact. The Newton hypothesis would be supported if the top-level research more frequently cites previously highly-cited work than that medium-level research cites highly-cited work. Our analysis is based on (i) all articles and proceedings papers which were published in 2003 in the life sciences, health sciences, physical sciences, and social sciences, and (ii) all articles and proceeding papers which were cited within these publications. The results show that highly-cited work in all scientific fields more frequently cites previously highly-cited papers than that medium-cited work cites highly-cited work. We demonstrate that papers contributing to the scientific progress in a field lean to a larger extent on previously important contributions than papers contributing little. These findings support the Newton hypothesis and call into question the Ortega hypothesis (given our usage of citation counts as a proxy for impact).

Work, Family Roles and Support Systems. CEW Series No. 3: New Research on Women.

ERIC Educational Resources Information Center

Golden, Susan, Ed.

The volume presents five research papers and sixteen reports of research in progress which examine the relationship of women to work, family roles, and support systems. The papers examine internal factors influencing women's goals, racial differences in why women work, how work and family roles are integrated, class differences as determinants of…

"Not Footprints Behind but Footsteps Forward": Working Class Women Who Teach

ERIC Educational Resources Information Center

Maguire, Meg

2005-01-01

This paper draws on in-depth interviews with five working class women who work/have worked as schoolteachers in inner city settings. The paper explores their subjective and continuing engagement with their class origins--their footprints in their past--as well as the way in which social class is implicated in their professional contemporary…

Welfare Reform and Community Colleges: A Policy and Research Context. MDRC Working Paper.

ERIC Educational Resources Information Center

Brock, Thomas; Matus-Grossman, Lisa; Hamilton, Gayle

This paper reports on the state of welfare after the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) passed by Congress in 1996. The National Evaluation of Welfare-to-Work Strategies (NEWWS) is a federally initiated study that explores the questions of what works best and for whom. NEWWS evaluated seven areas across the…

Working in the People's Republic of China.

ERIC Educational Resources Information Center

Schnulle, Linda

Primarily the result of observations made during an eighteen-day tour of the People's Republic of China (conducted by Professor Eugene Gilliom at Ohio State University), this paper examines working conditions and attitudes toward work in China. Focus in the first half of the paper is on motivation to work in China and how it differs from U.S.…

The Effect of Union Type on Work-Life Conflict in Five European Countries

ERIC Educational Resources Information Center

Kasearu, Kairi

2009-01-01

This paper explores the strategies for reconciling family and work in different union types. The focus here is on investigating how cohabiting and married individuals perceive the work-life conflict in different European countries. To test the union type impact on work-life balance in the context of different societal conditions, this paper draws…

Papers from the Linguistics Laboratory. Working Papers in Linguistics, No. 50.

ERIC Educational Resources Information Center

Ainsworth-Darnell, Kim, Ed.; D'Imperio, Mariapaola, Ed.

Research reports included in this volume of working papers in linguistics are: "Perception of Consonant Clusters and Variable Gap Time" (Mike Cahill); "Near-Merger in Russian Palatalization" (Erin Diehm, Keith Johnson); "Breadth of Focus, Modality, and Prominence Perception in Neapolitan Italian" (Mariapaola…

Papers in Syntax. Working Papers in Linguistics No. 42.

ERIC Educational Resources Information Center

Kathol, Andreas, Ed.; Pollard, Carl, Ed.

1993-01-01

This collection of working papers in syntax includes: "Null Objects in Mandarin Chinese" (Christie Block); "Toward a Linearization-Based Approach to Word Order Variation in Japanese" (Mike Calcagno); "A Lexical Approach to Inalienable Possession Constructions in Korean" (Chung, Chan); "Chinese NP Structure"…

Cost minimizing of cutting process for CNC thermal and water-jet machines

NASA Astrophysics Data System (ADS)

Tavaeva, Anastasia; Kurennov, Dmitry

2015-11-01

This paper deals with optimization problem of cutting process for CNC thermal and water-jet machines. The accuracy of objective function parameters calculation for optimization problem is investigated. This paper shows that working tool path speed is not constant value. One depends on some parameters that are described in this paper. The relations of working tool path speed depending on the numbers of NC programs frames, length of straight cut, configuration part are presented. Based on received results the correction coefficients for working tool speed are defined. Additionally the optimization problem may be solved by using mathematical model. Model takes into account the additional restrictions of thermal cutting (choice of piercing and output tool point, precedence condition, thermal deformations). At the second part of paper the non-standard cutting techniques are considered. Ones may lead to minimizing of cutting cost and time compared with standard cutting techniques. This paper considers the effectiveness of non-standard cutting techniques application. At the end of the paper the future research works are indicated.

Poverty Alleviation, Work and Adult Learning. Report of the UIE Round Table Held during the International Congress on Vocational Education and Training (2nd, Seoul, Korea, April 26-30, 1999). UIE Working Paper.

ERIC Educational Resources Information Center

Singh, Madhu, Ed.

This document contains six papers about and from a roundtable discussion of poverty alleviation, work, and adult learning. The "Introduction" (Madhu Singh) presents an overview of the roundtable. "Work-Related Adult Education: Challenges and Possibilities in Poverty Areas" (Enrique Pieck) describes work-related adult education…

Behaviour and Beliefs of Volunteer Literacy Tutors. Working Paper No. 3

ERIC Educational Resources Information Center

Hambly, Catherine

2011-01-01

This is the third paper published by The Centre for Literacy in its Working Papers in Literacy series, which presents fresh perspectives on literacy-related issues. The topics are relevant both to other researchers, to practitioners in the field, and to policy-makers. This paper examines the behaviours and beliefs of a group of volunteer tutors to…

[Pleural mesothelioma in women in the Veneto Region who used to work as rag sorters for textile recycling and paper production].

PubMed

Merler, E; Gioffrè, F; Rozio, L; Bizzotto, R; Mion, M; Sarto, F

2001-01-01

The paper reports 9 cases of mesothelioma diagnosed by means of histology or cytology that were observed among women resident in the Veneto Region, Northern Italy, whose only activity that could involve exposure to asbestos was as rag sorter. These cases are part of a group of about 260 subjects with mesothelioma whose entire working and residential history has been collected. The women worked as rag sorters between the 1940's and 1960's in textile recycling (8 cases) or (one case) at a paper mill where cotton was used for paper production. The work as rag sorter helps to explain the high proportion of mesotheliomas among women with an occupational exposure to asbestos.

Freud on Brothers and Sisters: A Neglected Topic

ERIC Educational Resources Information Center

Sherwin-White, Susan

2007-01-01

This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

Sources of funding for Nobel Prize-winning work: public or private?

PubMed

Tatsioni, Athina; Vavva, Effie; Ioannidis, John P A

2010-05-01

Funding is important for scientists' work and may contribute to exceptional research outcomes. We analyzed the funding sources reported in the landmark scientific papers of Nobel Prize winners. Between 2000 and 2008, 70 Nobel laureates won recognition in medicine, physics, and chemistry. Sixty five (70%) of the 93 selected papers related to the Nobel-awarded work reported some funding source including U.S. government sources in 53 (82%), non-U.S. government sources in 19 (29%), and nongovernment sources in 33 (51%). A substantial portion of this exceptional work was unfunded. We contacted Nobel laureates whose landmark papers reported no funding. Thirteen Nobel laureates responded and offered their insights about the funding process and difficulties inherent in funding. Overall, very diverse sources amounting to a total of 64 different listed sponsors supported Nobel-related work. A few public institutions, in particular the U.S. National Institutes of Health (with n=26 funded papers) and the National Science Foundation (with n=17 papers), stood out for their successful record for funding exceptional research. However, Nobel-level work arose even from completely unfunded research, especially when institutions offered a protected environment for dedicated scientists.

Edinburgh Working Papers in Applied Linguistics, 1996.

ERIC Educational Resources Information Center

Parkinson, Brian, Ed.; Mitchell, Keith

1996-01-01

This monograph contains papers on research work in progress at the Department of Applied Linguistics and Institute for Applied Language Studies at the University of Edinburgh (Scotland). Topics addressed include general English teaching, English for Academic Purposes teaching, Modern Language teaching, and teacher education. Papers are:…

From Working Parties to Social Work: Middle-Class Girls' Education and Social Service 1890-1914

ERIC Educational Resources Information Center

Brewis, Georgina

2009-01-01

This paper considers the voluntary work of girls in late Victorian and Edwardian Britain. Historians have so far neglected to study social work as an integral part of middle-class girls' formal and informal education. The paper uses records of several little-known girls' service leagues including Time and Talents, Girl's Realm Guild of Service,…

High-Tech, Hard Work: An Investigation of Teachers' Work in the Digital Age

ERIC Educational Resources Information Center

Selwyn, Neil; Nemorin, Selena; Johnson, Nicola

2017-01-01

This paper explores the ways in which digital technologies are now implicated in the work--and specifically the labour--of school teachers. Drawing upon qualitative studies in two Australian high schools, the paper examines the variety of ways in which teachers' work is now enacted and experienced along digital lines. In particular, the paper…

Integration of Work and Learning. Proceedings of the Workshop on Curriculum Innovation (2nd, Bled, Slovenia, September 1997).

ERIC Educational Resources Information Center

European Training Foundation, Turin (Italy).

This proceedings consists of 13 papers and 3 working group presentations from a 3-day workshop on issues of work-linked learning relevant for curriculum development. "Welcome" (Slavko Gaber, Peter de Rooij) is followed by two introductory papers: "Integration of Work and Learning: A Challenge for Both Schools and Companies"…

Correlates of Employment among High School Seniors. Monitoring the Future Occasional Paper Series, Paper 20.

ERIC Educational Resources Information Center

Bachman, Jerald G.; And Others

To explore costs and benefits of part-time work for high school students, survey responses of high school seniors from the classes of 1980 through 1984 were examined, distinguishing between those working many hours, those working fewer hours, and those not employed. Because hours of work differed by sex and by college plans, most analyses…

78 FR 18630 - Records Schedules; Availability and Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... speeches, program files, records of senior-level boards, and substantive working papers. 11. Office of the... reference materials, non-substantive drafts, routine briefings and speeches, staff level working groups, Web... speeches, drafts, non-substantive working papers, reference files, and the internal Web site. Proposed for...

Working Papers in Art Education, 1996-1997.

ERIC Educational Resources Information Center

Thunder-McGuire, Steve

1997-01-01

This collection of working papers in art education is comprised of manuscripts by graduate students presented at the National Art Education Conference. Papers in this issue reflect several educational settings and geographic areas. The 22 articles include: (1) "Symbolic Meanings in the Ghanaian Arts: A Step Towards Developing Cultural Literacy"…

Accreditation of Health Educational Programs. Part II: Staff Working Papers.

ERIC Educational Resources Information Center

Study of Accreditation of Selected Health Educational Programs, Washington, DC.

This publication contains a second set of working papers concerned with procedures of the accrediting agencies in the health fields, the accountability and social responsibility of accreditation, and the relationship of accreditation to certification, licensure, and registration. Texts of these papers are included: (1) "Dilemmas of Accreditation…

China in Mexico: More Opportunity than Risk

DTIC Science & Technology

2011-10-17

FDI Quality, and Plant Mortality,” World Development 37, 6 (2011): 1069- 1082 , http://ea.panam.edu/cbes/pdf/WorkingPaper1- 06.pdf. 26 Ayala, “The...1069- 1082 , http://ea.panam.edu/cbes/pdf/WorkingPaper1- 06.pdf. 9 What the study did identify were policies pursuing “proximity dependent...Mortality.” World Development 37, 6, (2011): 1069- 1082 . http://ea.panam.edu/cbes/pdf/WorkingPaper1-06.pdf. 19 Sauvant, Karl P., and Ken Davies

An overview of the USL/DBMS NASA/PC R and D project working paper series

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor)

1984-01-01

An introduction is given to the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA/PC R and D Working Paper Series which has been established to provide a foundation for both a formal and informal information dissemination mechanism concerning PC-based research and development activities being performed pursuant to the NASA contract. This entry also serves as an index to the collection of Working Paper Series reports.

The TV Development Concept Papers. Preliminary Working Draft. Occasional Papers, Vol. 1, No. 4.

ERIC Educational Resources Information Center

To Educate the People Consortium, Detroit, MI.

This working paper is an intermediary stage in the development of a new telecurriculum for the To Educate the People Consortium. Section 1 is an introduction to the process. Section 2 contains the outlines of 18 courses in the telecurriculum based on concept papers submitted by teams from the consortium. Each course is in the format of six 1-hour…

The Electronic Cottage. State-of-the-Art Paper.

ERIC Educational Resources Information Center

Morf, Martin; Alexander, Philip

This paper provides an overview of the information currently available on the prospects of electronic work at home. The first major section examines the technological environment that makes electronic home work possible. Central and dispersed computer facilities, internal and external means of communication, work stations, software, and security…

Education and Training for Work. Volume 1--Planning Programs.

ERIC Educational Resources Information Center

Campbell, Clifton P., Ed.

This book, which is intended for practicing or aspiring instructors, curriculum developers, and others engaged in work force development at the secondary and postsecondary levels, contains eight papers explaining how to plan education and training for work. The following papers are included: "Determining the Market Demand for Skilled Workers"…

The Changing Shape of Work.

ERIC Educational Resources Information Center

Brown, Richard K., Ed.

This book contains nine papers that were presented to the Sociology and Social Policy section of the British Association for the Advancement of Science. The first paper, "Introduction: Work and Employment in the 1990s" (Richard Brown), puts work and employment in a historical context and examines how globalization of the economy has…

Edinburgh Working Papers in Applied Linguistics, Number 4.

ERIC Educational Resources Information Center

Davies, Alan

1993-01-01

"Edinburgh Working Papers" is intended to show a yearly cross-section of current work in Edinburgh's Department of Applied Linguistics and to elicit reactions and criticism. Articles in this volume include the following: "MSC Common Room Conversations: Topics and Terms" (Joan Cutting); "Speculation and Empiricism in Applied Linguistics" (Alan…

Hypermedia Ethnography in Educational Settings: Possibilities and Challenges

ERIC Educational Resources Information Center

Coffey, Amanda; Renold, Emma; Dicks, Bella; Soyinka, Bambo; Mason, Bruce

2006-01-01

This paper considers some of the methodological implications of undertaking and representing multimedia and digital, ethnographic work. It explores some of the challenges and opportunities of working with and across a range of media, and explores some of the consequences of bringing hypermedia applications to ethnographic work. The paper draws on…

What Students Produce from the Net: Assessing Their Work.

ERIC Educational Resources Information Center

1996

Two papers that examine how to assess students' work in this age of electronic information sources include: "Students on the Net: Enhancing Learning through Authentic Assessment" (James Henri); and "Assessing Students' Work from the Net: An Impossible Dream?" (Paul Lupton) The first paper notes the problem of parents doing…

Becoming an A & E nurse.

PubMed

Sbaih, L C

1997-10-01

This is the first of four papers which examine the work of Accident and Emergency (A & E) nurses. The descriptions in this and the following three papers have emerged from an ethnomethodological study which sought to obtain the views of what A & E nurses believed their work to be. All are rooted in nurses' accounts of the ways in which nursing work is talked about and accomplished within the A & E setting. It should be noted that all four papers describe the ordinary rather than the extraordinary and should hold no surprises for those familiar with A & E nursing work. This first paper explores the ways in which nurses become A & E nurses, however, before descriptions can be put forward, an introduction to the study from which they have emerged needs to be made.

What Works for Disconnected Young People: A Scan of the Evidence. MDRC Working Paper

ERIC Educational Resources Information Center

Treskon, Louisa

2016-01-01

The purpose of this paper was to conduct a scan of the current state of the evidence regarding what works in helping disconnected young people, defined as the population of young people ages 16 to 24 who are not connected to work or school. The following four main research questions were investigated: (1) What local, state, and federal policies…

The Storage and Transmission of Men's Non-Formal Skills in Working Class Communities: A Working Paper. NALL Working Paper.

ERIC Educational Resources Information Center

Smith, Dorothy E.

A descriptive study observed the transmission of manual job skills from older to younger men in working class communities in Ontario and the effects of massive downsizing in industrial plants on this process. Current as well as previous ethnographic research was used. Some of the outcomes of the continual downsizing included the following: (1) the…

"Opt-Out" Rates at Motherhood across High-Education Career Paths: Selection versus Work Environment. NBER Working Paper No. 14717

ERIC Educational Resources Information Center

Herr, Jane Leber; Wolfram, Catherine

2009-01-01

This paper examines the propensity of highly educated women to exit the labor force at motherhood. We focus on systematic differences across women with various graduate degrees to analyze whether these speak to differences in the capacity to combine children with work over a variety of high-education career paths. Working with a sample of Harvard…

Progress by the JWST Science Working Group

NASA Technical Reports Server (NTRS)

Gardner, Jonathan P.

2007-01-01

The JWST Science Working Group recently published a comprehensive, top-level review of JWST science in the journal Space Science Reviews (Gardner et al. 2006, SSR, 123, 485). That review paper gives details of the 4 JWST science themes, and describes the design of the observatory and ground system. Since publication, the SWG, working with members of the astronomical community, has continued to develop the science case for JWST, giving more details in a series of white papers. The white paper topics include first light, galaxy surveys, AGN, supernovae, stellar populations, and exoplanets. The white papers are in various stages of completion. In this poster, I will review recent progress.

Working Papers in Dialogue Modeling, Volume 2.

ERIC Educational Resources Information Center

Mann, William C.; And Others

The technical working papers that comprise the two volumes of this document are related to the problem of creating a valid process model of human communication in dialogue. In Volume 2, the first paper concerns study methodology, and raises such issues as the choice between system-building and process-building, and the advantages of studying cases…

Ethics and Engineering. Working Papers Series Volume 2.

ERIC Educational Resources Information Center

Cutcliffe, Stephen H., Ed.

This collection of essays is the second volume in a series of working papers from Lehigh University Technology Studies Resource Center. The papers focus on the ethical implications of engineering as a profession and the current problems associated with the public responsibility of engineers. Issues that relate to the ethical dimensions of…

Kansas Working Papers in Linguistics, Volume 17, Numbers 1 and 2.

ERIC Educational Resources Information Center

Linn, Mary Sarah, Ed.; Oliverio, Giulia R. M., Ed.

"Kansas Working Papers in Linguistics" is intended as a forum for the presentation of the latest original research by the faculty and students of the Department of Linguistics and other related departments of the University of Kansas. Papers in this volume include: "Some Issues in Japanese Accent" (Kenneth Miner);…

Accreditation of Health Educational Programs. Part 1: Staff Working Papers.

ERIC Educational Resources Information Center

Study of Accreditation of Selected Health Educational Programs, Washington, DC.

This publication contains the first set of working papers concerned with structure, financing, research, and expansion as they relate to the accreditation of health education programs conducted by professional agencies. Texts of these papers are included: (1) "Historical Introduction to Accreditation of Health Educational Programs" by W.K. Selden,…

Contradictions in Portfolio Careers: Work Design and Client Relations

ERIC Educational Resources Information Center

Fenwick, Tara J.

2006-01-01

Purpose: The paper aims to explore "Portfolio work", an emerging form of flexible self-employment, which has been identified as significant but under-researched. This paper also seeks to explore the challenges and benefits of portfolio work from the perspective of individuals' experiences. Design/methodology/approach: The argument draws from a…

Academic Work: The Changing Labour Process in Higher Education.

ERIC Educational Resources Information Center

Smyth, John, Ed.

This collection of papers examines what academics do as a work process and how that is changing dramatically with the fiscal crises being experienced by most governments around the world. It explores how academic work is organized, how it is enacted, in whose interests, and with what ultimate effects. Papers include: "Markets in Higher…

Group Work in Schools: A Process Consultation Approach

ERIC Educational Resources Information Center

Farouk, Shaalan

2004-01-01

This paper provides a description of how an educational psychologist can consult with groups of teachers mostly in relation to their work with pupils who display emotional behavioural difficulties. The paper includes a review of the work on group consultation in schools, followed by a description of process consultation (Schein, 1988 ) and how the…

The Algebra Initiative Colloquium. Volume 2: Working Group Papers.

ERIC Educational Resources Information Center

Lacampagne, Carole B., Ed.; And Others

This volume presents recommendations from four working groups at a conference on reform in algebra held in Leesburg, Virginia, December 9-12, 1993. Working Group 1: Creating an Appropriate Algebra Experience for All Grades K-12 Students produced the following papers: (1) "Report" (A. H. Schoenfeld); (2) "Five Questions About Algebra…

Seeing Epistemic Order: Construction and Transmission of Evaluative Criteria

ERIC Educational Resources Information Center

Shalem, Yael; Slonimsky, Lynne

2010-01-01

This paper focuses on formative assessment in the field of higher education. It examines Bernstein's work on vertical discourses and knowledge structures with the view to deepening understanding of the concept of assessment "for" learning. The first part of the paper draws on Vygotsky's work on concept development and Bernstein's work on…

Roger Bastide: the social construction on the border of disciplines. Mental illness as a field of study.

PubMed

Nunes, Everardo Duarte

2015-05-01

The paper explores the contributions of Roger Bastide (1898-1974) to the field of insanity and mental illness, revisiting his work in social psychiatry, psychoanalysis, psychology and, sociology of mental disorder. It highlights the interdisciplinary nature that marks Bastide's works, that also include religion, art, literature. The paper presents biographical data and highlights the importance of Bastide to the field of sociology of health/illness. The analysis situates Bastide's work at the time of its development, comparing it with the development of the sociology of mental illness today.The paper explores the contributions of Roger Bastide (1898-1974) to the field of insanity and mental illness, revisiting his work in social psychiatry, psychoanalysis, psychology and, sociology of mental disorder. It highlights the interdisciplinary nature that marks Bastide's works, that also include religion, art, literature. The paper presents biographical data and highlights the importance of Bastide to the field of sociology of health/illness. The analysis situates Bastide's work at the time of its development, comparing it with the development of the sociology of mental illness today.

Introduction to NASA Living With a Star (LWS) Institute GIC Working Group Special Collection

NASA Technical Reports Server (NTRS)

Pulkkinen, A.

2017-01-01

This paper is a brief introduction to the NASA Living With a Star (LWS) Institute GIC Working Group Special Collection that is product of work by a group of researchers from more than 20 different international organizations. In this introductory paper, I summarize the group's work in the context of novel NASA LWS Institute element and introduce the individual contributions in the collection.

The Teaching of Evidence-Based Practice in Social Work Higher Education--Living by the Charlie Parker Dictum: A Response to Papers by Shlonsky and Stern, and Soydan

ERIC Educational Resources Information Center

Springer, David W.

2007-01-01

This article, as a response to two papers, identifies five critical issues and themes related to the teaching of evidence-based practice (EBP) in social work higher education. These five themes are: defining EBP; modeling the complexity of EBP in teaching; examining social work curriculum; coordinating social work professional organizations; and…

76 FR 43206 - Electronic Tariff Filing System (ETFS)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

...) Working papers and statistical data. (1) Concurrently with the filing of any tariff change or tariff... explanation of how the working papers relate to that information. (2) All statistical studies must be...

Emerging Issues in Science and Technology, 1982. A Compendium of Working Papers for the National Science Foundation.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC.

Presented are nine working papers prepared for the National Science Foundation as one means of assisting the Office of Science and Technology Policy in preparing the administration's "Annual Science and Technology Report to the Congress, 1982." The papers explore aspects of three broad themes central to the administration's science and…

The Aging Work Force: A Guide for Higher Education Administrators.

ERIC Educational Resources Information Center

Julius, Nancy B., Ed.; Krauss, Herbert H., Ed.

This volume offers 15 papers on the "graying" of the college and university work force in the context of national demographic trends. The papers are arranged in groups which address: growing older, the graying of America, adapting to changing times, retirement and retirement planning, and the corporate example. The following papers are presented:…

Web-GIS based information management system to Bureau of Law Enforcement for Urban Managementenforcement for urban management

NASA Astrophysics Data System (ADS)

Sun, Hai; Wang, Cheng; Ren, Bo

2007-06-01

Daily works of Law Enforcement Bureau are crucial in the urban management. However, with the development of the city, the information and data which are relative to Law Enforcement Bureau's daily work are increasing and updating. The increasing data result in that some traditional work is limited and inefficient in daily work. Analyzing the demands and obstacles of Law Enforcement Bureau, the paper proposes a new method to solve these problems. A web-GIS based information management system was produced for Bureau of Law Enforcement for Urban Management of Foshan. First part of the paper provides an overview of the system. Second part introduces the architecture of system and data organization. In the third part, the paper describes the design and implement of functional modules detailedly. In the end, this paper is concluded and proposes some strategic recommendations for the further development of the system. This paper focuses on the architecture and implementation of the system, solves the developing issues based on ArcServer, and introduces a new concept to the local government to solve the current problems. Practical application of this system showed that it played very important role in the Law Enforcement Bureau's work.

Work stress and the risk of recurrent coronary heart disease events: A systematic review and meta-analysis.

PubMed

Li, Jian; Zhang, Min; Loerbroks, Adrian; Angerer, Peter; Siegrist, Johannes

2015-01-01

Though much evidence indicates that work stress increases the risk of incident of coronary heart disease (CHD), little is known about the role of work stress in the development of recurrent CHD events. The objective of this study was to review and synthesize the existing epidemiological evidence on whether work stress increases the risk of recurrent CHD events in patients with the first CHD. A systematic literature search in the PubMed database (January 1990 - December 2013) for prospective studies was performed. Inclusion criteria included: peer-reviewed English papers with original data, studies with substantial follow-up (> 3 years), end points defined as cardiac death or nonfatal myocardial infarction, as well as work stress assessed with reliable and valid instruments. Meta-analysis using random-effects modeling was conducted in order to synthesize the observed effects across the studies. Five papers derived from 4 prospective studies conducted in Sweden and Canada were included in this systematic review. The measurement of work stress was based on the Demand- Control model (4 papers) or the Effort-Reward Imbalance model (1 paper). According to the estimation by meta-analysis based on 4 papers, a significant effect of work stress on the risk of recurrent CHD events (hazard ratio: 1.65, 95% confidence interval: 1.23-2.22) was observed. Our findings suggest that, in patients with the first CHD, work stress is associated with an increased relative risk of recurrent CHD events by 65%. Due to the limited literature, more well-designed prospective research is needed to examine this association, in particular, from other than western regions of the world. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

The good work--a Swedish trade union vision in the shadow of lean production.

PubMed

Johansson, Jan; Abrahamsson, Lena

2009-07-01

"The Good Work" (Det goda arbetet) was established as a highly praised and established concept in the Swedish working life debate in the middle of the 1980s. In this paper, we are going to discuss the concept in relation to the massive introduction of lean production in Swedish industry. The aim of this paper is to restore the theory of the good work into the industrial society of today. We will search for a model for 'good work' in balance between the demands from production and good conditions for a learning environment. The theoretical base for this paper will be found in both organisational research and research on production technology systems. We identify three strong trends in Swedish industrial companies giving both pitfalls and possibilities for the good work; the learning focus as a way to increase productivity and improve working conditions; Lean Production in most cases imply narrow short-cyclic work tasks; and the global market that reduces national discretion. As a result, we formulate a new set of criteria for "the good work".

Cognitive work hardening: a return-to-work intervention for people with depression.

PubMed

Wisenthal, Adeena; Krupa, Terry

2013-01-01

Mental health claims in the workplace are rising, particularly those due to depression. Associated with this is an increase in disability costs for the employer and the disability insurer, but even more important is the human suffering that results. While treatments are available for the depression there is a gap in interventions that specifically target return-to-work preparation. This paper presents cognitive work hardening, a treatment intervention that can bridge this gap by addressing the unique functional issues inherent in depression with a view to increasing return-to-work success. Cognitive work hardening applies the proven principles of classical work hardening (which has typically been applied to people with physical injuries) to the mental health domain. This paper explains how the occupational therapy principle of occupation and the core competency, enablement, are utilized and applied in cognitive work hardening. Key skills of the occupational therapist are also discussed. In addition, the paper considers the relationship of cognitive work hardening to recovery and mental illness, and the role it plays among workplace-based return-to-work interventions in the current movement toward non-clinical return-to-work interventions.

International Social Work Field Placement or Volunteer Tourism? Developing an Asset-Based Justice-Learning Field Experience

ERIC Educational Resources Information Center

Sossou, Marie-Antoinette; Dubus, Nicole

2013-01-01

This paper examines a developing model for building an international social work placement that meets the needs of the host agency and community first. The paper addresses the challenges for social work departments to develop a strong learning environment while also keeping primary the needs of the host community and agency.

"Brothers Gonna Work It Out:" Understanding the Pedagogic Performance of African American Male Teachers Working with African American Male Students

ERIC Educational Resources Information Center

Brown, Anthony L.

2009-01-01

Drawing from ethnographic data, this paper explores how African American male teachers working with African American male students performed their pedagogy. This paper highlights how teachers' understanding of African American males social and educational needs shaped their pedagogical performance. Interestingly however, teachers' performance was…

Effective Faculty Evaluation at the Teaching-Centered University: Building a Fair and Authentic Portfolio of Faculty Work

ERIC Educational Resources Information Center

Lakin, Amy L.

2016-01-01

Purpose: The purpose of this paper is to determine the most fair, authentic, and reliable elements to include in a portfolio of faculty work, specifically at teaching-centered institutions. Design/methodology/approach: This paper examines and evaluates relevant literature pertaining to faculty portfolios of work and recommends portfolio formats…

The Impact of Quantum Theoretical Models of Consciousness on the Study of Education.

ERIC Educational Resources Information Center

Andris, James F.

This paper abstracts and discusses the approaches of five educational theorists who have used quantum theory as a model for educational phenomena, sets forth and uses metatheoretical criteria to evaluate the work of these theorists, and states guidelines for further work in this domain. The paper abstracts and discusses the works of the following…

The Political Participation of Working Youth and College Students. CIRCLE Working Paper 36

ERIC Educational Resources Information Center

Jarvis, Sharon E.; Montoya, Lisa; Mulvoy, Emily

2005-01-01

Unprecedented attention has gone to researching young voters, and yet one segment of this age group has been largely ignored: non-college (or "working") youth. Because very little is known about them, the following paper advances three fundamental concerns: What types of political activities do young workers engage in? What can be learned about…

Education and Its Poverty-Reducing Effects: The Case of Paraiba, Brazil. World Bank Policy Research Working Paper 3321

ERIC Educational Resources Information Center

Verner, Dorte

2004-01-01

The Policy Research Working Paper Series disseminates the findings of work in progress to encourage the exchange of ideas about development issues. Breaking the inter-generational transmission of poverty requires far-reaching actions in the education sector. Widespread poverty affects both students' performance and their availability to attend…

Dilemmatic Spaces: High-Stakes Testing and the Possibilities of Collaborative Knowledge Work to Generate Learning Innovations

ERIC Educational Resources Information Center

Singh, Parlo; Märtsin, Mariann; Glasswell, Kathryn

2015-01-01

This paper examines collaborative researcher-practitioner knowledge work around assessment data in culturally diverse, low socio-economic school communities in Queensland, Australia. Specifically, the paper draws on interview accounts about the work of a cohort of school-based researchers who acted as mediators bridging knowledge flows between a…

Perceptions of Women Academics Regarding Work-Life Balance: A Pakistan Case

ERIC Educational Resources Information Center

Naz, Sadaf; Fazal, Shawana; Khan, Muhammad Ilyas

2017-01-01

Work-life balance in the context of this paper means keeping a balance between home and workplace responsibilities and roles. In more traditional societies, such as in Pakistan, working women often find it difficult to keep a balance between their responsibilities in the workplace and their home responsibilities. This paper is based on findings…

Travaux Neuchatelois de linguistique (Neuchatel Working Papers in Linguistics).

ERIC Educational Resources Information Center

Neuchatel Univ. (Switzerland). Inst. de Linguistique.

This collection of working papers in linguistics includes four works. "Autour de la racine indo-europeenne 'pet-' ('voler') (pour servir a l'histoire des faits latins)" ("Concerning the Indo-European Root 'Pet-' ('To Fly') (To Serve as an Example of Latin Facts)" by Claude Sandoz looks at the Latin manifestations of the root and illustrates the…

Flex-Time. A Catalyst Occasional Paper.

ERIC Educational Resources Information Center

Catalyst, New York, NY.

Contains history, case studies, and discussion of the use and benefits of flex-time employment, a pattern of working hours in which individual employees begin and end their work day at times of their choice, within certain limits, as long as they work a prescribed number of hours. The paper addresses the following topics: (1) What is flex-time,…

How Technology Changes Demands for Human Skills. OECD Education Working Papers, No. 45

ERIC Educational Resources Information Center

Levy, Frank

2010-01-01

This paper places the competencies to be measured by the OECD's Programme for the International Assessment of Adult Competencies (PIAAC) in the context of the technological developments which are reshaping the nature of the workplace and work in the 21st century. The largest technological force currently shaping work is the computer. Computers are…

Systematic review of the qualitative literature on return to work after injury.

PubMed

MacEachen, Ellen; Clarke, Judy; Franche, Renée-Louise; Irvin, Emma

2006-08-01

This paper reports on a systematic review of the international qualitative research literature on return to work. This review was undertaken in order to better understand the dimensions, processes, and practices of return to work. Because return to work often includes early return before full recovery while a person is undergoing rehabilitation treatment, physical recovery is embedded in complicated ways with workplace processes and practices and social organization. These process-oriented dimensions of return to work are well described in the qualitative literature. This systematic review of the literature covered peer-reviewed papers that focused on musculoskeletal and pain-related injuries and were published in English or French between 1990 and 2003. Findings from papers meeting relevance and quality criteria were synthesized using the meta-ethnographic approach. This review found that return to work extends beyond concerns about managing physical function to the complexities related to beliefs, roles, and perceptions of many players. Good will and trust are overarching conditions that are central to successful return-to-work arrangements. In addition, there are often social and communication barriers to return to work, and intermediary players have the potential to play a key role in facilitating this process. This paper identifies key mechanisms of workplace practice, process, and environment that can affect the success of return to work. The findings illustrate the contribution that qualitative literature can make to important aspects of implementation in relation to return to work.

Time to Work or Time to Play: The Effect of Student Employment on Homework, Housework, Screen Time, and Sleep. Working Paper 423

ERIC Educational Resources Information Center

Kalenkoski, Charlene Marie; Pabilonia, Sabrina Wulff

2009-01-01

Recent research suggests that working while in high school reduces the amount of time students spend doing homework. However, an additional hour of work leads to a reduction in homework by much less than one hour, suggesting a reduction in other activities. This paper uses data from the 2003-2007 American Time Use Surveys (ATUS) to investigate the…

Griffith Edwards, the Addiction Research Unit and research on the criminal justice system.

PubMed

Farrell, Michael; Marsden, John; Strang, John

2015-07-01

This paper reviews the early work of Griffith Edwards and his colleagues on alcohol in the criminal justice system and outlines the direction of research in this area in the Addiction Research Unit in the 1960s and 1970s. The paper outlines the link between that work and work undertaken in the more recent past in this area. The key papers of the authors are reviewed and the impact of this work on policy and practice is discussed. There is a rich seam of work on deprived and incarcerated populations that has been under way at the Addiction Research Unit and subsequently the National Addiction Centre, Institute of Psychiatry, London. Griffith Edwards initiated this work that explores the risks and problems experienced by people moving between the health and criminal justice system, and demonstrated the need for better care and continuity across this system. © 2015 Society for the Study of Addiction.

Working Paper 5: American High Schools; Some Organizational Characteristics and Factors Related to Teacher Satisfaction, Counselor Satisfaction, and the Quality of Counseling Programs. Interim Report.

ERIC Educational Resources Information Center

Johnston, Lloyd D.; And Others

This working paper is the fifth in a series on Youth in Transition. Included are four papers plus comments on these papers. The findings are based on information gathered from approximately 2,000 high school teachers and 300 counselors. The teachers' and counselors' perceptions of the way our high schools are run and the impact of those schools on…

Study on power grid characteristics in summer based on Linear regression analysis

NASA Astrophysics Data System (ADS)

Tang, Jin-hui; Liu, You-fei; Liu, Juan; Liu, Qiang; Liu, Zhuan; Xu, Xi

2018-05-01

The correlation analysis of power load and temperature is the precondition and foundation for accurate load prediction, and a great deal of research has been made. This paper constructed the linear correlation model between temperature and power load, then the correlation of fault maintenance work orders with the power load is researched. Data details of Jiangxi province in 2017 summer such as temperature, power load, fault maintenance work orders were adopted in this paper to develop data analysis and mining. Linear regression models established in this paper will promote electricity load growth forecast, fault repair work order review, distribution network operation weakness analysis and other work to further deepen the refinement.

Schooling, work satisfaction and productivity: an examination of Jeremy Bentham.

PubMed

Lyons, R G

1998-01-01

This paper examines the ethical dimensions of work productivity and work satisfaction. This issue is explored by looking at the ethical theory of Jeremy Bentham. He argues that work satisfaction is so highly subjective and personal that we can school people to experience work satisfaction when in the most distasteful jobs. Bentham argues that, from the perspective of the principle of utility, there is nothing wrong with schooling some people to experience work satisfaction from what seems like distasteful work. This paper suggests that Bentham's theory justifies class relationship and flies in the face of the notion of equality of job opportunity.

Work-life balance/imbalance: the dominance of the middle class and the neglect of the working class.

PubMed

Warren, Tracey

2015-12-01

The paper was stimulated by the relative absence of the working class from work-life debates. The common conclusion from work-life studies is that work-life imbalance is largely a middle-class problem. It is argued here that this classed assertion is a direct outcome of a particular and narrow interpretation of work-life imbalance in which time is seen to be the major cause of difficulty. Labour market time, and too much of it, dominates the conceptualization of work-life and its measurement too. This heavy focus on too much labour market time has rendered largely invisible from dominant work-life discourses the types of imbalance that are more likely to impact the working class. The paper's analysis of large UK data-sets demonstrates a reduction in hours worked by working-class men, more part-time employment in working-class occupations, and a substantial growth in levels of reported financial insecurity amongst the working classes after the 2008-9 recession. It shows too that economic-based work-life imbalance is associated with lower levels of life satisfaction than is temporal imbalance. The paper concludes that the dominant conceptualization of work-life disregards the major work-life challenge experienced by the working class: economic precarity. The work-life balance debate needs to more fully incorporate economic-based work-life imbalance if it is to better represent class inequalities. © London School of Economics and Political Science 2015.

Statistical Policy Working Paper 24. Electronic Dissemination of Statistical Data

DOT National Transportation Integrated Search

1995-11-01

The report, Statistical Policy Working Paper 24, Electronic Dissemination of Statistical Data, includes several topics, such as Options and Best Uses for Different Media Operation of Electronic Dissemination Service, Customer Service Programs, Cost a...

Kansas Working Papers in Linguistics.

ERIC Educational Resources Information Center

Khym, Hangyoo, Ed.; Kookiattikoon, Supath, Ed.

1997-01-01

The seven working papers on linguistic theory contained in this volume include: "Two Properties of the Intransitive Resultative Construction" (Yoichi Miyamoto); "Multiple Subject Construction in Korean: A Functional Explanation" (Youngjun Jang); "Constraints on Noun Incorporation in Korean" (Hangyoo Khym);…

1979 SIGNUM meeting on numerical ordinary differential equations. [University Inn, Champaign, IL, April 3-5, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skeel, R. D.

1979-04-01

This report gives a summary of the papers presented at the meeting. It consists of all working papers distributed at the conference and all working papers received too late for distribution. In addition, abstracts and/or summaries are included where practical for those talks and workshop sessions that did not generate papers. This document should be a useful reference to very current research in ODEs. These papers are preliminary versions of papers that will be submitted for publication. One paper in this volume has been cited in ERA, and can be located by reference to the entry CONF-790403-- in the Reportmore » Number Index.« less

Hispanic/Latina Women and AIDS: A Critical Perspective. JSRI Working Paper No. 36. JSRI Research & Publications Working Paper Series.

ERIC Educational Resources Information Center

Blasini-Caceres, Lydia; Cook, Amy Beth

Women are a rapidly growing group of people with AIDS in the United States, and Hispanic/Latina and African American women are disproportionately represented. This paper reviews the literature on the epidemiology of AIDS/HIV infection among Latina women, children, and adolescents and discusses the needs of Latinas regarding AIDS prevention…

Treatability of five Appalachian wood species with creosote and timbor®

Treesearch

Jeffrey J. Slahor; Curt C. Hassler; Rodney C. DeGroot; Douglas J. Gardner

2000-01-01

The work described in this paper culminates an investigation into the treatability of five Appalachian hardwood species. Previous papers have described work using the waterborne preservatives CCA-C and ACQ-B. This paper details the results of pressure treatment with creosote and Timbor®. Six-inch long nominal two-by-four samples of red maple, yellow-poplar, red oak,...

Economic Growth and Poverty Reduction: Measurement and Policy Issues. OECD Development Centre Working Paper No. 246

ERIC Educational Resources Information Center

Klasen, Stephan

2005-01-01

The aim of this Working Paper is to broaden the debate on "pro-poor growth". An exclusive focus on the income dimension of poverty has neglected the non-income dimensions. After an examination of prominent views on the linkages between economic growth, inequality, and poverty reduction this paper discusses the proper definition and…

Work Papers of the Summer Institute of Linguistics: University of North Dakota Session, Volume 39.

ERIC Educational Resources Information Center

Bickford, J. Albert, Ed.

This volume contains an index to volumes 18-38 (1974-1994) of the "Work Papers of the Summer Institute of Linguistics" (Stephen A. Marlett and J. Albert Bickford) as well as the following 1995 papers: "Laryngeal Licensing and Syllable Well-formedness in Quiengolani Zapotec" (Cherly A. Black); "A Grammar Sketch of the Kaki…

Intelligent transportation system (ITS) study for the Buffalo and Niagara Falls metropolitan area, Erie and Niagara Counties, New York : objectives, performance criteria & user service plan, working paper #3

DOT National Transportation Integrated Search

1997-06-18

This paper is the third in a series that together will comprise an Intelligent Transportation System Study (ITS) for the Buffalo/Niagara Falls region. In this document, the problems identified in Working Paper #1 are critically reviewed to develop go...

Delineation of State Agency, Accreditation, and Institutional Responsibilities. Improving Community College Evaluation and Planning: Project Working Paper Number Four.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Office of the Chancellor.

One of a series of papers resulting from a Fund for the Improvement of Postsecondary Education (FIPSE) project to improve evaluation and planning in community colleges, this working paper presents a plan of purposes and activities to experimentally test a model of delineation of responsibilities among accrediting commissions, state agencies, and…

Workpapers in Teaching English as a Second Language. Vol. 7.

ERIC Educational Resources Information Center

Gorman, T. P., Ed.

This is the seventh volume in a continuing series of working papers on teaching English as a second language. The 13 papers included here represent work in progress and cover a wide variety of subjects. In the first paper, E. Hatch summarizes research on reading a second language. S. J. A. Garcia discusses some of the areas of controversy in the…

Comparing School-Level to Private Higher Education: Using the Dominican Republic as a Pioneer Study. PROPHE Working Paper Series. WP No. 8

ERIC Educational Resources Information Center

Mendoza, Ancell Scheker

2007-01-01

This working paper reviews concepts and categories developed in private higher education research, analyzing their applicability to lower levels of education. Most specifically and prominently, the paper uses the three waves of private growth identified in Latin American higher education--Catholic, elite, and demand-absorbing--and categories of…

Materials Toward the Comparative Analysis of Presentation Techniques. Project TACT Working Paper 2.

ERIC Educational Resources Information Center

Bossert, William H.; Oettinger, Anthony G.

One of the objectives of Project TACT is to determine the potential of a gamut of educational media. The working papers in this set have a basis in pictorial information produced through computer graphics. These papers are intended to serve as a basis for sharpening questions, delineating the context within which the answers might be significant,…

Bridging the Skills Gap. Working Paper Part II: High Technology and Related Occupations.

ERIC Educational Resources Information Center

Kaplan, Christine E.

This part of a 2-part working paper identifies and describes major occupational groups that are characteristic of high technology manufacturing and service industries as well as employment sectors that use high technology products in their provision of goods and services. The paper is based on a review of a wide range of employment projections…

A Discourse on Ethics and the Corporate Workplace: Can Ethics Be Taught? Working Paper 2.

ERIC Educational Resources Information Center

Martinsons, Barbara, Ed.

This working paper is one in a series of policy statements on the relationship between liberal education and careers in business; it covers a seminar discussing ethics and the teaching of morality. Papers given by seven professionals in the corporate and academic world are included. After an introduction to the seminar and a statement on corporate…

The Arizona Board of Regents' Task Force on Excellence, Efficiency and Competitiveness. The Final Report and Working Papers. Volume Two.

ERIC Educational Resources Information Center

Arizona Board of Regents, Phoenix.

Volume Two of a report by the Arizona Board of Regents' independent citizen commission to examine the performance of the state's three public universities presents 26 working papers in four sections. Section One, Research and Graduate Education/Universities: A State Resource, offers five papers, including: "University Research and Economic…

Rapid ILs-polishing Processes Toward Flexible Nanostructured Paper with Dually High Transparency and Haze.

PubMed

Ou, Yanghao; Chen, Jinbo; Lu, Pengbo; Cheng, Fan; Lin, Meiyan; Su, Lingfeng; Li, Jun; Liu, Detao

2017-07-31

Biodegradable highly nanostructured paper has received great interest in past years due to its excellent optical properties which facilitate its wide applications in green flexible electronics and devices. However, energy and/or time-consuming procedure during the process of fabricating most nanostructured transparent paper are presently the main obstacle to their scalable production. In this work, we demonstrated a novel nanostructured paper with dually high transparency (∼91%) and high haze (∼89%) that was directly fabricated from original paper with rapid ILs-polishing processes. The whole fabricating time only requires 10 min. Compared to the previously reported nanopaper made of the isolated cellulose nanofibers by pure mechanical and/or chemical approaches, this work presented herein is devoted to use green ILs to polish directly the micrometer-sized fibrous paper into the nanostructured paper. This new method brings a rapid fabrication of transparent nanostructured paper while also retaining dual intriguing properties both in optical transmittance and haze. This work is capable of fabricating next-generation flexible and highly transparent and haze paper by a high-speed roll-to-roll manufacturing process with a much lower cost.

Do Raffles Boys "Rule" and Anglo-Chinese Boys "Own" Singapore? Analysing School-to-Work Correspondences in an Elite Developmental State

ERIC Educational Resources Information Center

Chua, Vincent

2015-01-01

This paper utilises ideas of correspondence as a way of thinking about intersections between school and work in Singapore's developmental state. Whereas the principle of correspondence predicts segregated patterns of association between school and work, this paper shows how a developmentalist form of political economy gives rise to crosscutting,…

Relationship of Child Abuse to the Workplace: Employer-Based Strategies for Prevention. Prevention Focus Working Paper No. 4.

ERIC Educational Resources Information Center

Coolson, Peter

This background paper examines the relationship between child abuse and the workplace and discusses employer-based strategies that can reduce the stress levels of working parents and provide a buffer against problems of child abuse and neglect. Part 1, "Child Abuse and the World of Work," discusses the kinds of stress experienced by…

Contemporary Macro-Issues in Human Work Organizations--Agenda for the Scientist-Practitioner in Organizational Communication.

ERIC Educational Resources Information Center

Keenan, James J.

This paper presents a brief survey of several contemporary macro-issues in human work organizations as context for--and part of the work of--scientists-practitioners in organizational communication. A special attempt has been made to identify concerns or issues--called "TransIssues" for the purposes of this paper--that appear to cut across two…

Replication in Interaction and Working Memory Research: Révész (2012) and Goo (2012)

ERIC Educational Resources Information Center

Gass, Susan; Valmori, Lorena

2015-01-01

This paper argues for the replication of two studies, both of which consider feedback and working memory. In the first part of this paper, we discuss the role of interaction-based research and working memory research in second language acquisition research. We then describe two studies that have unified these two areas in recent published articles…

Time Students Spend Working at Home for School

ERIC Educational Resources Information Center

Wagner, Petra; Schober, Barbara; Spiel, Christiane

2008-01-01

The paper presents three studies which deal with the time students spend working at home for school. In addition, the paper focuses on the distribution of time investment over the course of a week and on the relationship between academic achievement and time spent working at home for school. In sum, 824 students with an average age of 15 years…

Understanding Accounting as a Career: An Immersion Work Experience for Students Making Career Decisions

ERIC Educational Resources Information Center

McGrath, Dianne; Murphy, Daniel

2016-01-01

This paper reports on a project which is designed to increase the participation of high school students in accounting work experience placements. The focus of the paper is on an Australian-based project which overcomes the identified barriers to offering high school accounting work experience placements with a resultant increase in the number and…

Advancing Work Practices: Rethinking Online Professional Development in the Context of the Intervention-Based Sustainable Change

ERIC Educational Resources Information Center

Noesgaard, Signe Schack

2016-01-01

Purpose: The paper aims to discuss the effectiveness of e-Learning in advancing work practices. The paper investigates the assumption that e-Learning is as effective as face-to-face interventions when stimulating change. It also examines the assumption that well-designed and well-executed instructional interventions will advance work practices.…

Work and Family Responsibilities: Achieving a Balance. A Program Paper of the Ford Foundation.

ERIC Educational Resources Information Center

Ford Foundation, New York, NY.

The relationship between work and family is an issue of growing concern in the United States. The increasing participation of women in the labor force has created new demands for services, especially for low-income families, to offset women's dual responsibilities at work and home. This paper describes a Ford Foundation program to study the place…

Education and Work.

ERIC Educational Resources Information Center

Poole, Millicent E., Ed.

This book contains 13 papers that identify major education and work issues related to post-compulsory schooling in Australia. The following papers are included: "Changing Policy Perspectives" (Millicent E. Poole); "A Historical Essay" (Andrew Spaull); "A Philosophical Perspective" (Colin W. Evers); "School to…

Integrated Cost Accounting System.

DTIC Science & Technology

1992-07-27

D., Srikant M. Datar, and Sunder Kekre . "Relevant Costs, Congestion, and Stochasticity in Production Environments." unpublished working paper...School, 1984. 113 Kekre , Sunder . "Strategic Consideration of Order Flexibility, Costs, and Delivery in Long-Term Contracts." Unpublished Working Paper

Work environments for employee creativity.

PubMed

Dul, Jan; Ceylan, Canan

2011-01-01

Innovative organisations need creative employees who generate new ideas for product or process innovation. This paper presents a conceptual framework for the effect of personal, social-organisational and physical factors on employee creativity. Based on this framework, an instrument to analyse the extent to which the work environment enhances creativity is developed. This instrument was applied to a sample of 409 employees and support was found for the hypothesis that a creative work environment enhances creative performance. This paper illustrates how the instrument can be used in companies to select and implement improvements. STATEMENT OF RELEVANCE: The ergonomics discipline addresses the work environment mainly for improving health and safety and sometimes productivity and quality. This paper opens a new area for ergonomics: designing work environments for enhancing employee creativity in order to strengthen an organisation's capability for product and process innovation and, consequently, its competitiveness.

Spotted fever Rickettsia species in Hyalomma and Ixodes ticks infesting migratory birds in the European Mediterranean area

PubMed Central

2014-01-01

Background A few billion birds migrate annually between their breeding grounds in Europe and their wintering grounds in Africa. Many bird species are tick-infested, and as a result of their innate migratory behavior, they contribute significantly to the geographic distribution of pathogens, including spotted fever rickettsiae. The aim of the present study was to characterize, in samples from two consecutive years, the potential role of migrant birds captured in Europe as disseminators of Rickettsia-infected ticks. Methods Ticks were collected from a total of 14,789 birds during their seasonal migration northwards in spring 2009 and 2010 at bird observatories on two Mediterranean islands: Capri and Antikythira. All ticks were subjected to RNA extraction followed by cDNA synthesis and individually assayed with a real-time PCR targeting the citrate synthase (gltA) gene. For species identification of Rickettsia, multiple genes were sequenced. Results Three hundred and ninety-eight (2.7%) of all captured birds were tick-infested; some birds carried more than one tick. A total number of 734 ticks were analysed of which 353 ± 1 (48%) were Rickettsia-positive; 96% were infected with Rickettsia aeschlimannii and 4% with Rickettsia africae or unidentified Rickettsia species. The predominant tick taxon, Hyalomma marginatum sensu lato constituted 90% (n = 658) of the ticks collected. The remaining ticks were Ixodes frontalis, Amblyomma sp., Haemaphysalis sp., Rhipicephalus sp. and unidentified ixodids. Most ticks were nymphs (66%) followed by larvae (27%) and adult female ticks (0.5%). The majority (65%) of ticks was engorged and nearly all ticks contained visible blood. Conclusions Migratory birds appear to have a great impact on the dissemination of Rickettsia-infected ticks, some of which may originate from distant locations. The potential ecological, medical and veterinary implications of such Rickettsia infections need further examination. PMID:25011617

Development of loop-mediated isothermal amplification assay for specific and rapid detection of differential goat pox virus and sheep pox virus.

PubMed

Zhao, Zhixun; Fan, Bin; Wu, Guohua; Yan, Xinmin; Li, Yingguo; Zhou, Xiaoli; Yue, Hua; Dai, Xueling; Zhu, Haixia; Tian, Bo; Li, Jian; Zhang, Qiang

2014-01-17

Capripox viruses are economically important pathogens in goat and sheep producing areas of the world, with specific focus on goat pox virus (GTPV), sheep pox virus (SPPV) and the Lumpy Skin Disease virus (LSDV). Clinically, sheep pox and goat pox have the same symptoms and cannot be distinguished serologically. This presents a real need for a rapid, inexpensive, and easy to operate and maintain genotyping tool to facilitate accurate disease diagnosis and surveillance for better management of Capripox outbreaks. A LAMP method was developed for the specific differential detection of GTPV and SPPV using three sets of LAMP primers designed on the basis of ITR sequences. Reactions were performed at 62°C for either 45 or 60 min, and specificity confirmed by successful differential detection of several GTPV and SPPV isolates. No cross reactivity with Orf virus, foot-and-mouth disease virus (FMDV), A. marginale Lushi isolate, Mycoplasma mycoides subsp. capri, Chlamydophila psittaci, Theileria ovis, T. luwenshuni, T. uilenbergi or Babesia sp was noted. RFLP-PCR analysis of 135 preserved epidemic materials revealed 48 samples infected with goat pox and 87 infected with sheep pox, with LAMP test results showing a positive detection for all samples. When utilizing GTPV and SPPV genomic DNA, the universal LAMP primers (GSPV) and GTPV LAMP primers displayed a 100% detection rate; while the SPPV LAMP detection rate was 98.8%, consistent with the laboratory tested results. In summary, the three sets of LAMP primers when combined provide an analytically robust method able to fully distinguish between GTPV and SPPV. The presented LAMP method provides a specific, sensitive and rapid diagnostic tool for the distinction of GTPV and SPPV infections, with the potential to be standardized as a detection method for Capripox viruses in endemic areas.

TB-IRIS and remodelling of the T cell compartment in highly immunosuppressed HIV+ patients with TB: the CAPRI T (ANRS-12614) study

PubMed Central

Haridas, V.; Pean, P.; Jasenosky, L.D.; Madec, Y.; Laureillard, D.; Sok, T.; Sath, S.; Borand, L.; Marcy, O.; Chan, S.; Tsitsikov, E.; Delfraissy, J.-F.; Blanc, F.-X.; Goldfeld, A.E.

2015-01-01

Objective To investigate the impact of tuberculosis (TB)-associated immune reconstitution syndrome (IRIS) upon immunological recovery and the T cell compartment after initiation of TB and antiretroviral therapy (ART). Design and methods We prospectively evaluated T cell immunophenotypes by flow cytometry and cytokines by Luminex assays in a subset (n=154) of highly immunosuppressed HIV+ patients with TB from the CAMELIA randomized clinical trial. We compared findings from patients who developed TB-IRIS to findings from patients who did not develop TB-IRIS. Data were evaluated with mixed effect linear regression, Kaplan-Meier estimates, and Wilcoxon rank sum tests, and q-values were calculated to control for multiple comparisons. Results Development of TB-IRIS was associated with significantly greater pre-ART frequencies of HLA-DR+CD45RO+CD4+, CCR5+CD4+, OX40+CD4+, and Fas+ effector memory (EM) CD8+ T cells, and significantly elevated levels of plasma IL-6, IL-1β, IL-8, and IL-10 and viral load. Post-ART initiation, EM CD4+ and Fas+ EM CD4+ T cell frequencies significantly expanded, and central memory (CM) CD4+ T cell frequencies significantly contracted in patients who experienced TB-IRIS. By week 34 post-TB treatment initiation, EM/CM CD4+ T cell ratios were markedly higher in TB-IRIS versus non-TB-IRIS patients. Conclusions A distinct pattern of pre-ART T cell and cytokine markers appear to poise the immune response to develop TB-IRIS. Experience of TB-IRIS is then associated with long-term remodeling of the CD4+ T cell memory compartment towards an EM-dominated phenotype. We speculate that these pre- and post-ART TB-IRIS-associated immune parameters may contribute to superior immune control of TB/HIV co-infection and better clinical outcome. PMID:25486415

Building macromolecular assemblies by information-driven docking: introducing the HADDOCK multibody docking server.

PubMed

Karaca, Ezgi; Melquiond, Adrien S J; de Vries, Sjoerd J; Kastritis, Panagiotis L; Bonvin, Alexandre M J J

2010-08-01

Over the last years, large scale proteomics studies have generated a wealth of information of biomolecular complexes. Adding the structural dimension to the resulting interactomes represents a major challenge that classical structural experimental methods alone will have difficulties to confront. To meet this challenge, complementary modeling techniques such as docking are thus needed. Among the current docking methods, HADDOCK (High Ambiguity-Driven DOCKing) distinguishes itself from others by the use of experimental and/or bioinformatics data to drive the modeling process and has shown a strong performance in the critical assessment of prediction of interactions (CAPRI), a blind experiment for the prediction of interactions. Although most docking programs are limited to binary complexes, HADDOCK can deal with multiple molecules (up to six), a capability that will be required to build large macromolecular assemblies. We present here a novel web interface of HADDOCK that allows the user to dock up to six biomolecules simultaneously. This interface allows the inclusion of a large variety of both experimental and/or bioinformatics data and supports several types of cyclic and dihedral symmetries in the docking of multibody assemblies. The server was tested on a benchmark of six cases, containing five symmetric homo-oligomeric protein complexes and one symmetric protein-DNA complex. Our results reveal that, in the presence of either bioinformatics and/or experimental data, HADDOCK shows an excellent performance: in all cases, HADDOCK was able to generate good to high quality solutions and ranked them at the top, demonstrating its ability to model symmetric multicomponent assemblies. Docking methods can thus play an important role in adding the structural dimension to interactomes. However, although the current docking methodologies were successful for a vast range of cases, considering the variety and complexity of macromolecular assemblies, inclusion of some kind of experimental information (e.g. from mass spectrometry, nuclear magnetic resonance, cryoelectron microscopy, etc.) will remain highly desirable to obtain reliable results.

Lifetime Learning Trajectories: Close Encounters of Five Kinds. Patterns of Participation in Adult Education and Training. Working Paper 7.

ERIC Educational Resources Information Center

Gorard, Stephen; Rees, Gareth; Fevre, Ralph; Furlong, John

This working paper is a product of a regional study in industrial South Wales of the determinants of participation and non-participation in post-compulsory education and training, with special reference to processes of change in the patterns of these determinants over time and to variations between geographical areas. This paper describes the…

John Dewey: Su filosofia y filosofia de la educacion (John Dewey: His Philosophy and Philosophy of Education). Working Paper.

ERIC Educational Resources Information Center

Zoreda, Margaret Lee

This paper forms part of an investigation about how the philosophy of John Dewey (1859-1952) can illuminate the practice of the teaching of English as a foreign language. The paper seeks to interpret and synthesize John Dewey's philosophical works to construct a "Deweyian lens" with which to analyze and evaluate the field of the teaching…

Radio for Education and Development: Case Studies, Volume I. World Bank Staff Working Paper No. 266.

ERIC Educational Resources Information Center

Spain, Peter L.; And Others

Six papers describe use of the radio for in-school and out-of-school formal education in this first volume of working papers on how radio can and is being used for education and development. Part one on in-school education contains: a Nicaraguan project to teach mathematics to first grade children (including curriculum, materials, teacher…

Planning and Accreditation: A Survey of Attitudes of Policymakers. Improving Community College Evaluation and Planning: Project Working Papers Numbers Five, Six, and Seven.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Office of the Chancellor.

One of a series of papers resulting from a Fund for the Improvement of Postsecondary Education (FIPSE) project to improve evaluation and planning in community colleges, this working paper presents the results of interviews with community college policymakers conducted to assess their views on matters such as non-governmental accreditation,…

40 CFR 80.620 - What are the additional requirements for diesel fuel or distillates produced by foreign...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Accountant in the United States and a citizen of the United States, or be approved in advance by EPA based on... petition has not been approved, and any work papers related to refinery baseline establishment; (B) The... papers; and (G) Reports prepared for submission to EPA, and any work papers related to such reports. (vi...

40 CFR 80.620 - What are the additional requirements for diesel fuel or distillates produced by foreign...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Accountant in the United States and a citizen of the United States, or be approved in advance by EPA based on... petition has not been approved, and any work papers related to refinery baseline establishment; (B) The... papers; and (G) Reports prepared for submission to EPA, and any work papers related to such reports. (vi...

Systems scenarios: a tool for facilitating the socio-technical design of work systems.

PubMed

Hughes, Helen P N; Clegg, Chris W; Bolton, Lucy E; Machon, Lauren C

2017-10-01

The socio-technical systems approach to design is well documented. Recognising the benefits of this approach, organisations are increasingly trying to work with systems, rather than their component parts. However, few tools attempt to analyse the complexity inherent in such systems, in ways that generate useful, practical outputs. In this paper, we outline the 'System Scenarios Tool' (SST), which is a novel, applied methodology that can be used by designers, end-users, consultants or researchers to help design or re-design work systems. The paper introduces the SST using examples of its application, and describes the potential benefits of its use, before reflecting on its limitations. Finally, we discuss potential opportunities for the tool, and describe sets of circumstances in which it might be used. Practitioner Summary: The paper presents a novel, applied methodological tool, named the 'Systems Scenarios Tool'. We believe this tool can be used as a point of reference by designers, end-users, consultants or researchers, to help design or re-design work systems. Included in the paper are two worked examples, demonstrating the tool's application.

Working paper : national costs of the metropolitan ITS infrastructure : updated with 2004 deployment data

DOT National Transportation Integrated Search

The purpose of this report, "Working Paper National Costs of the Metropolitan ITS infrastructure: Updated with 2004 Deployment Data," is to update the estimates of the costs remaining to deploy Intelligent Transportation Systems (ITS) infrastructure ...

Multi-Modal Traveler Information System - Gateway Design Options

DOT National Transportation Integrated Search

1997-05-19

The purpose of this working paper is to provide insight into the options that are available from which to design the Gateway Traveler Information System (TIS). This working paper will discuss each option in a general manner without becoming overly te...

MITA Working Papers in Psycholinguistics, Volume 3.

ERIC Educational Resources Information Center

Otsu, Yukio, Ed.

1993-01-01

This volume of working papers in psycholinguistics, from the "MITA Psycholinguistics Circle", contains the following articles: "Some Problems in the Acquisition of Derived Nouns" (Mika Endo); "World Knowledge in Children's Sentence Comprehension" (Yuki Hirose); "Examining the Including and Excluding Roles of…

Aid to private transportation providers : a working paper.

DOT National Transportation Integrated Search

1979-01-01

This working paper was prepared for the Public Transportation Division. Within the three-week period in which it was prepared, little more than a cursory examination could be made of the number of private providers operating in Virginia; however, the...

Protecting children: intuition and awareness in the work of health visitors.

PubMed

Ling, M S; Luker, K A

2000-09-01

Protecting children: intuition and awareness in the work of health visitors This paper is based upon an ethnographic study of a group of health visitors engaged in child protection work. The purpose of this paper is to explore the meanings individual health visitors attach to events concerned with identifying children who may be at risk of harm from child abuse, and also the idiosyncratic nature of health visiting in this complex but everyday social situation. The paper focuses on understanding the importance of a particular form of knowledge which the health visitors referred to as 'intuitive awareness'.

The Consequences of Age at First Childbirth: Labor Force Participation and Earnings. Working Paper: 1146-04.

ERIC Educational Resources Information Center

Hofferth, Sandra L.; And Others

The primary focus of this paper is on the impact an early birth has on later labor force participation and earnings of women. Variables affecting the participation of women in a given year and factors affecting the total work experience are discussed in detail. These include: hours worked, annual earnings, hourly wages, occupational status, race,…

Working With Children? The Probability of Mothers Exiting the Workforce at Time of Birth. Working Paper 2008-8

ERIC Educational Resources Information Center

Hotchkiss, Julie L.; Pitts, M. Melinda; Walker, Mary Beth

2008-01-01

Recent trends in the labor force participation of women have brought much public attention to the issue of women opting out. This paper explores the decision of working women to exit the labor market at a time of major transition--the birth of a child--utilizing linked vital statistics, administrative employer, and state welfare records. The…

"We Must Have Writers": An Introduction to the Narrative Rhetorical Theory of Meridel LeSueur.

ERIC Educational Resources Information Center

Allen, Julia M.

This paper examines the life and works of Meridel LeSueur, a colleague of Kenneth Burke, and herself a radical writer during the 1920s and 1930s. The paper states that LeSueur's primary aim was to establish an indigenous working-class culture to support working-class action. It notes that her arguments about writing build upon the rhetorical…

Family Policy in Hungary: How to Improve the Reconciliation between Work and Family? OECD Economics Department Working Papers, No. 566

ERIC Educational Resources Information Center

Hemmings, Philip

2007-01-01

Hungarian family policy focuses on providing generous options to take time off work to look after children. This system not only contributes to Hungary's low employment rate but encourages long separation from the labour market, has largely failed to significantly influence fertility rates and is relatively expensive to run. This paper looks at…

Social Learning among People Who Are Excluded from the Labor Market. Part One: Context and Case Studies. NALL Working Paper.

ERIC Educational Resources Information Center

Church, Kathryn; Fontan, Jean-Marc; Ng, Roxana; Shragge, Eric

This working paper lays groundwork for a Network for New Approaches to Lifelong Learning study on informal learning by people displaced from the labor market or chronically unemployed, in the context of community organizations. Section 1 examines the context and two particularly significant features--wider changes in the nature of work and related…

Agora VII: Working Time, Training Time (Thessaloniki, Greece, October 7-8, 1999). CEDEFOP Panorama Series.

ERIC Educational Resources Information Center

Guggenheim, Eric Fries, Ed.

This document contains the agenda and papers on work and training presented at the Agora VII meeting in Thessaloniki, Greece in October, 1999. The Foreword describes each session with a list of the topics and papers, along with a brief introduction to the topics. The three sessions are: Work and Training in Society in the 21st Century; Working…

Getting published well requires fulfilling editors' and reviewers' needs and desires.

PubMed

Schoenwolf, Gary C

2013-12-01

Publication in international scientific journals provides an unparalleled opportunity for authors to showcase their work. Where authors publish affects how the community values the work. This value directly determines the impact of the work on the field-papers must be read and cited to advance the field, and because the scientific literature is vast, only a subset of the literature is widely read and cited. Moreover, the value placed on the work also affects the authors' scientific reputation and career advancement. Consequently, it is essential that manuscripts receive the recognition they deserve by being published in one of the "best" journals that the scientific findings allow. Several factors determine where a paper is published: how well the topic of the paper fits the scope of the journal, the quality of the study and the manuscript describing it, the advance the paper makes in its field, the importance of the advance, and the extent to which the paper impacts the broader community of science. As scientists, we assume that our papers will be assessed objectively using only well defined scientific standards, but editors and reviewers also view papers subjectively, having biases of what defines a high-quality publication based on Western standards. Therefore, scientists trained in other parts of the world can be significantly disadvantaged in getting their papers published in the best journals. Here, I present concrete suggestions for improving the perception of a paper in the reader's minds, increasing the likelihood that it will get published well. © 2013 The Authors Development, Growth & Differentiation © 2013 Japanese Society of Developmental Biologists.

Good work - how is it recognised by the nurse?

PubMed

Christiansen, Bjørg

2008-06-01

The aim of this paper is to shed light on how nurses describe situations that reflect achievement and provide confirmation that they have done good work. Nurses' recognition of good work does not seem to have been the object of direct investigation, but is indirectly reflected in studies focusing on nurses' perceptions on work environments and the multifaceted nature of nursing. However, acknowledging high-quality performance in professional nurses can facilitate nurses in maintaining and strengthening the goals and values of the profession. This in turn can help nurses shoulder the multifaceted responsibilities they have to patients and next of kin. This paper is part of the Professional Learning in a Changing Society project, Institute of Educational Research, University of Oslo, funded by the Research Council of Norway. The project involves four professional groups. This paper, however, focuses on a group of 10 nurses, nine of whom work in hospitals and one in an outpatient clinic. A qualitative approach was chosen to gain insight into how nurses, as well as the other professional groups in the project, engage in processes of knowledge production and quality assurance work. Data presented in this paper derive from semi-structured in-depth interviews conducted during spring 2005 and focuses on the recognition of good work. The following themes were identified as essential in confirming that one did good work: securing fundamental needs of patients and next of kin; managing the flow of responsibilities; positive feedback. CONCLUSIONS. Good work seems to be related to specific situations and a sense of achievement by the respondents. Recognition of good work is not only rewarding and enjoyable; it may also serve as a source of consciousness raising for professional and ethical guidelines in the work place.

Statistical Policy Working Paper 25. Data Editing Workshop and Exposition

DOT National Transportation Integrated Search

1996-12-01

Statistical Policy Working Paper 25 is the written record of the Data Editing Workshop and Exposition held March 22, 1996, at the Bureau of Labor Statistics (BLS) Conference and Training Center. The program consisted of 44 oral presentations and 19 s...

Working paper : national costs of the metropolitan ITS infrastructure : updated with 2005 deployment data

DOT National Transportation Integrated Search

2006-07-01

The purpose of this report, "Working Paper National Costs of the Metropolitan ITS Infrastructure: Updated with 2005 Deployment Data," is to update the estimates of the costs remaining to fully deploy Intelligent Transportation Systems (ITS) infrastru...

Action Learning at Work.

ERIC Educational Resources Information Center

Mumford, Alan, Ed.

This book contains 34 papers examining the theory, process, and outcomes of action learning at work. The following papers are included: "An Introduction to the Text" (Alan Mumford); "The Learning Equation" (Reg Revans); "Action Learning as a Vehicle for Learning" (Alan Mumford); "Placing Action Learning and…

Issues Related to Effects of New Maintenance Concept on AF Specialists Working in the Field

DOT National Transportation Integrated Search

1990-03-07

This working paper was prepared by the Transportation Systems Center, Operator : performance and Safety Analysis Division (DTS-45) for the Federal Aviation Ad : ministration. The paper provides initial thinking on groups of human resource issues : re...

Multi-Modal Traveler Information System - Gateway Phased Implementation Plan

DOT National Transportation Integrated Search

1997-11-25

The purpose of this working paper is to provide the main concepts and elements that need to be addressed in the overall implementation of the Gateway, both the Initial Phase and the Ultimate Phase. This working paper addresses these concepts and elem...

The Female Sex Work Industry in a District of India in the Context of HIV Prevention

PubMed Central

Buzdugan, Raluca; Halli, Shiva S.; Hiremath, Jyoti M.; Jayanna, Krishnamurthy; Raghavendra, T.; Moses, Stephen; Blanchard, James; Scambler, Graham; Cowan, Frances

2012-01-01

HIV prevalence in India remains high among female sex workers. This paper presents the main findings of a qualitative study of the modes of operation of female sex work in Belgaum district, Karnataka, India, incorporating fifty interviews with sex workers. Thirteen sex work settings (distinguished by sex workers' main places of solicitation and sex) are identified. In addition to previously documented brothel, lodge, street, dhaba (highway restaurant), and highway-based sex workers, under-researched or newly emerging sex worker categories are identified, including phone-based sex workers, parlour girls, and agricultural workers. Women working in brothels, lodges, dhabas, and on highways describe factors that put them at high HIV risk. Of these, dhaba and highway-based sex workers are poorly covered by existing interventions. The paper examines the HIV-related vulnerability factors specific to each sex work setting. The modes of operation and HIV-vulnerabilities of sex work settings identified in this paper have important implications for the local programme. PMID:23346389

The Female Sex Work Industry in a District of India in the Context of HIV Prevention.

PubMed

Buzdugan, Raluca; Halli, Shiva S; Hiremath, Jyoti M; Jayanna, Krishnamurthy; Raghavendra, T; Moses, Stephen; Blanchard, James; Scambler, Graham; Cowan, Frances

2012-01-01

HIV prevalence in India remains high among female sex workers. This paper presents the main findings of a qualitative study of the modes of operation of female sex work in Belgaum district, Karnataka, India, incorporating fifty interviews with sex workers. Thirteen sex work settings (distinguished by sex workers' main places of solicitation and sex) are identified. In addition to previously documented brothel, lodge, street, dhaba (highway restaurant), and highway-based sex workers, under-researched or newly emerging sex worker categories are identified, including phone-based sex workers, parlour girls, and agricultural workers. Women working in brothels, lodges, dhabas, and on highways describe factors that put them at high HIV risk. Of these, dhaba and highway-based sex workers are poorly covered by existing interventions. The paper examines the HIV-related vulnerability factors specific to each sex work setting. The modes of operation and HIV-vulnerabilities of sex work settings identified in this paper have important implications for the local programme.

Designing a ticket to ride with the Cognitive Work Analysis Design Toolkit.

PubMed

Read, Gemma J M; Salmon, Paul M; Lenné, Michael G; Jenkins, Daniel P

2015-01-01

Cognitive work analysis has been applied in the design of numerous sociotechnical systems. The process used to translate analysis outputs into design concepts, however, is not always clear. Moreover, structured processes for translating the outputs of ergonomics methods into concrete designs are lacking. This paper introduces the Cognitive Work Analysis Design Toolkit (CWA-DT), a design approach which has been developed specifically to provide a structured means of incorporating cognitive work analysis outputs in design using design principles and values derived from sociotechnical systems theory. This paper outlines the CWA-DT and describes its application in a public transport ticketing design case study. Qualitative and quantitative evaluations of the process provide promising early evidence that the toolkit fulfils the evaluation criteria identified for its success, with opportunities for improvement also highlighted. The Cognitive Work Analysis Design Toolkit has been developed to provide ergonomics practitioners with a structured approach for translating the outputs of cognitive work analysis into design solutions. This paper demonstrates an application of the toolkit and provides evaluation findings.

Equity and Quality? Challenges for Early Childhood and Primary Education in Ethiopia, India and Peru. Working Papers in Early Childhood Development, No. 55. Studies in Early Childhood Transitions

ERIC Educational Resources Information Center

Woodhead, Martin; Ames, Patricia; Vennam, Uma; Abebe, Workneh; Streuli, Natalia

2009-01-01

Part of the "Studies in Early Transitions" series, this Working Paper draws on interviews and observations carried out as part of "Young Lives", a 15-year longitudinal study of childhood poverty in Ethiopia, India, Peru and Vietnam based at the University of Oxford's Department of International Development. This paper focuses…

Nourishing People and Communities Through the Lean Years. Selected Papers of the National Institute on Social Work in Rural Areas (7th, Dubuque, IA, July 24-27, 1982).

ERIC Educational Resources Information Center

Jacobsen, G. Michael, Ed.

The papers selected for this reader represent the broad range of "practice oriented" interests, problems, populations, and interventions found in both rural social work and at the Seventh National Institute. Section 1 contains four papers which deal with program development and community practice, i.e., planning social services in a…

Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume II.

ERIC Educational Resources Information Center

Benson, Susan Shattuck: Bresie, Mayellen

Volume 2 contains 13 working papers from the 15th Seminar on Acquisition of Latin American Library Materials. The papers are: (1) A Report on Bibliographic Activities; (2) Microfilm Projects Newsletter; (3) Role of Latin American Legal Material in the Social Science Research Library; (4) A description of sources for Legal and Social Science…

Do Community-Managed Schools Work? An Evaluation of El Salvador's EDUCO Program. Working Paper Series on Impact Evaluation of Education Reforms. Paper No. 8.

ERIC Educational Resources Information Center

Jimenez, Emmanuel; Sawada, Yasuyuki

This paper measures the effects on student outcomes of decentralizing educational responsibility to communities and schools. In El Salvador, community-managed schools emerged during the 1980s when public schools could not be extended to rural areas because of the country's civil war. In 1991, El Salvador's Ministry of Education decided to draw on…

Ergonomics in industrially developing countries: a literature review.

PubMed

Huck-Soo, Loo; Richardson, Stanley

2012-12-01

The two final decades of the 20th century saw a significant increase in ergonomics activity (and resulting publications) in industrially developing countries (IDCs). However, a few ergonomics papers from Singapore, for example, were published in 1969 and 1970. This paper reviews developments in ergonomics in industrially developing countries from 1969 relying heavily on published papers although their quality varies considerably. Some criticism of these papers is offered. Most were concerned with the use of work tools, workstation operations, material handling and working environments especially in tropical climates. The similar problems encountered in a variety of countries are discussed, and the importance of low-cost solutions stressed. This study presents an overview of er gonomics research in IDCs. It concentrates on ASEAN countries whilst recognising the valuable work done in other areas.

Working paper : national costs of the metropolitan ITS infrastructure : update to the FHWA 1995 report

DOT National Transportation Integrated Search

2001-07-01

This working paper has been prepared to provide new estimates of the costs to deploy Intelligent Transportation System (ITS) infrastructure elements in the largest metropolitan areas in the United States. It builds upon estimates that were distribute...

Data Collection for Foreign Scholars. Working Paper #11.

ERIC Educational Resources Information Center

Dean, Michael F.

This working paper provides suggestions and considerations for anyone contemplating the electronic collection of data on foreign scholars (as distinct from international students). It is noted that, because the Immigration and Naturalization Service requires employment verification and immigration information such as country of citizenship and…

Working Paper : national costs of the metropolitan ITS infrastructure : update to the FHWA 1995 report

DOT National Transportation Integrated Search

2000-08-01

This working paper has been prepared to provide new estimates of the costs to deploy Intelligent Transportation System (ITS) infrastructure elements in the largest metropolitan areas in the United States. It builds upon estimates that were distribute...

Travaux Neuchatelois de Linguistique (TRANEL) (Neuchatel Working Papers in Linguistics), Volume 17.

ERIC Educational Resources Information Center

Rubattel, Christian, Ed.

1991-01-01

Papers in linguistics in this issue include: "Aspects logico-semantiques de la metaphore" ("Logico-Semantic Aspects of the Metaphor") (Michel le Guern); "Metaphore et travail lexicale" ("Metaphor and Lexical Work") (Georges Ludi); "Aspects linguistiques et pragmatiques de la metaphore: anomalie…

Working Papers in Linguistics 17.

ERIC Educational Resources Information Center

University of Trondheim Working Papers in Linguistics, 1993

1993-01-01

In this volume, five working papers are presented. "Accessing Contexts with Intonation" (Thorstein Fretheim) discusses the use of intonation as a tool for understanding the context of an utterance, particularly in combination with reference. Examples are offered in Norwegian. In "'Altsa' and 'Nemlig': Two Views of Causality"…

Penn Working Papers in Educational Linguistics, Volume 5, Number 2.

ERIC Educational Resources Information Center

Riley, Kathryn, Ed.

The working papers contained in this volume include the following: "Research on Language Learning; How Can It Respond to Classroom Concerns?" (Teresa Pica); "Building Rapport Through Indirect Complaints: Implications for Language Learning" (Diana Boxer); "(Bi)literacy and Empowerment: Education for Indigenous Groups in…

Problems of teaching students to use the featured technologies in the area of semantic web

NASA Astrophysics Data System (ADS)

Klimov, V. V.; Chernyshov, A. A.; Balandina, A. I.; Kostkina, A. D.

2017-01-01

The following paper contains the description of up-to-date technologies in the area of web-services development, service-oriented architecture and the Semantic Web. The paper contains the analysis of the most popular and widespread technologies and methods in the semantic web area which are used in the developed educational course. In the paper, we also describe the problem of teaching students to use these technologies and specify conditions for the creation of the learning and development course. We also describe the main exercise for personal work and skills, which all the students learning this course have to gain. Moreover, in the paper we specify the problem with software which students are going to use while learning this course. In order to solve this problem, we introduce the developing system which will be used to support the laboratory works. For this moment this system supports only the fourth work execution, but our following plans contain the expansion of the system in order to support the leftover works.

From boundaries to boundary work: middle managers creating inter-organizational change.

PubMed

Oldenhof, Lieke; Stoopendaal, Annemiek; Putters, Kim

2016-11-21

Purpose In healthcare, organizational boundaries are often viewed as barriers to change. The purpose of this paper is to show how middle managers create inter-organizational change by doing boundary work: the dual act of redrawing boundaries and coordinating work in new ways. Design/methodology/approach Theoretically, the paper draws on the concept of boundary work from Science and Technology Studies. Empirically, the paper is based on an ethnographic investigation of middle managers that participate in a Dutch reform program across health, social care, and housing. Findings The findings show how middle managers create a sense of urgency for inter-organizational change by emphasizing "fragmented" service provision due to professional, sectoral, financial, and geographical boundaries. Rather than eradicating these boundaries, middle managers change the status quo gradually by redrawing composite boundaries. They use boundary objects and a boundary-transcending vocabulary emphasizing the need for societal gains that go beyond production targets of individual organizations. As a result, work is coordinated in new ways in neighborhood teams and professional expertise is being reconfigured. Research limitations/implications Since boundary workers create incremental change, it is necessary to follow their work for a longer period to assess whether boundary work contributes to paradigm change. Practical implications Organizations should pay attention to conditions for boundary work, such as legitimacy of boundary workers and the availability of boundary spaces that function as communities of practice. Originality/value By shifting the focus from boundaries to boundary work, this paper gives valuable insights into "how" boundaries are redrawn and embodied in objects and language.

[Work and Family: Seeking a New Balance. Papers Presented at the National Conference on Work and Family (Washington, DC, March 30-31,1987).

ERIC Educational Resources Information Center

Gault, Stanley C.; Brock, William E.; Donahue, Thomas R.

Three conference papers explore issues related to work and the American family. The first, by Stanley C. Gault, Chairman of th Board of the National Association of Manufacturers, discusses recent changes in business practices that accommodate changes in the structure of the modern American family. The second, by Secretary of Labor, William E.…

Choosing Mars-Time: Analysis of the Mars Exploration Rover Experience

NASA Technical Reports Server (NTRS)

Bass, Deborah S.; Wales,Roxana C.; Shalin, Valerie L.

2004-01-01

This paper focuses on the Mars Exploration Rover (MER) mission decision to work on Mars Time and the implications of that decision on the tactical surface operations process as personnel planned activities and created a new command load for work on each Martian sol. The paper also looks at tools that supported the complexities of Mars Time work, and makes some comparisons between Earth and Mars time scheduling.

Work, Disability and Rehabilitation. Papers on Vocational Rehabilitation and Employment of People with Disabilities presented at the European Conference on Research in Rehabilitation (1st, Edinburgh, Scotland, April 6-8, 1983).

ERIC Educational Resources Information Center

Cornes, Paul, Ed.; Hunter, John, Ed.

Fifteen author-contributed papers are presented from the 1983 First European Conference on Research in Rehabilitation. The following titles and authors are represented: "Disability in a Large Public Sector Work Force" (D. Walker); "The Accidents and Absence of Disabled People at Work" (M. Kettle); "Employment…

Exploring Teacher Professional Learning for Future-Oriented Schooling: Working Paper 1 from the Back to the Future Project

ERIC Educational Resources Information Center

Gilbert, Jane; Bull, Ally

2014-01-01

This working paper sets out some of the early findings from a pilot project to explore the qualities that future-oriented teachers might need and how those qualities might be developed. The work began under a New Zealand Council for Educational Research (NZCER) project called Back to the Future and is now part of a Teaching & Learning Research…

The Need for Innovative Methods of Teaching and Learning Chemistry in Higher Education--Reflections from a Project of the European Chemistry Thematic Network

ERIC Educational Resources Information Center

Eilks, Ingo; Byers, Bill

2010-01-01

This paper summarizes the work and conclusions of a working group established by the European Chemistry Thematic Network (ECTN). The aim of the working group was to identify potential areas for innovative approaches to the teaching and learning of chemistry in Higher Education, and to survey good practice throughout the EU. The paper starts by…

Developing Literacy for the Workplace.

ERIC Educational Resources Information Center

Keeley, Meg

This paper presents a case and some ideas for integrating basic skills development with occupational training. Explaining why traditional instructional methods do not work in the workplace, the paper summarizes learning theories that support work force literacy programs. It explains how to identify the skills needed in the workplace, provides…

Combating Learning

ERIC Educational Resources Information Center

Jarvensivu, Anu; Koski, Pasi

2012-01-01

Purpose: The purpose of this paper is to look at workplace learning through research into sociology of work. It explores the "learning discourse" at work place level looking for possibilities to oppose learning. Design/methodology/approach: This paper is based on case studies conducted at six workplaces. The data on the cases include…

Scientific papers: A new paradigm

NASA Astrophysics Data System (ADS)

Reid, George C.

The problem of how to organize and write a scientific paper is a very basic one for most of us. A scientific paper is, after all, the only tangible product of a research scientist and, like all products, will be a failure if not marketed properly to reach its potential buyers. I think that a lack of attention to this “marketing and sales” aspect of research is a serious fault in our community, by which I mean those of us who publish in AGU journals.The potential audience for a scientific paper can be divided roughly into three distinct categories. The first group is usually rather small in number, consisting of fellow scientists working in a very closely related field, and to whom the details of the work are of major importance. The second group is also fellow scientists, but their interest is less sharply focused, and they are concerned with the broad outlines of the work and essential results. The third group is the sponsors and the people who actually pay for the work, whose interest in the details is minimal and they, sadly enough, are often concerned only with the fact that a paper has been published rather than its content.

Final Technical Report for contract number DE-FG02-05ER15670

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glazebrook, Jane

This is the final technical report for contract number DE-FG02-05ER15670. The project is now complete, and results of the project have been published. Two papers were published based on work done in the last three-year funding period. The DOIs of these papers are included below. The abstracts of the papers, providing summaries of the work, are included in the body of the report.

'To call it work somehow demeans it': the social construction of talk in the care of terminally ill patients.

PubMed

May, C

1995-09-01

The nurse has an important role in helping the terminally ill patient come to terms with the imminence of death. Such work is highly demanding and often stressful, but is work which is accorded a high moral priority by respondents in the study reported in this paper. The paper explores the ways in which nurses work to respond to patients' expressed psychosocial problems and the emphasis that they placed on providing opportunities for patients to speak about their impending death.

Factors related to difficulties with employment in patients with multiple sclerosis: a review of 2002-2011 literature.

PubMed

Schiavolin, Silvia; Leonardi, Matilde; Giovannetti, Ambra M; Antozzi, Carlo; Brambilla, Laura; Confalonieri, Paolo; Mantegazza, Renato; Raggi, Alberto

2013-06-01

We assess the knowledge available on the difficulties experienced by multiple sclerosis (MS) patients in work-related activities. A literature review was carried out using the keywords 'multiple sclerosis' and 'employment' or 'work' through PubMed and EMBASE. Papers reporting patient-derived data on difficulties at work as primary or secondary outcome measures and published in the period 2002-December 2011 were searched. A total of 26 papers were selected, for a total of 32 507 patients (mean age 46.2 years; 42.1% with relapsing-remitting MS). Most papers reported observational studies or cross-sectional surveys focused on health-related quality of life and MS costs. Symptoms more frequently addressed are fatigue, mobility and cognitive impairments. Limited research has been carried out on the working environment. We found a relatively small number of papers published in the last 10 years on the difficulties that patients with MS can experience at work, and this kind of information always appeared as a secondary outcome. In general, it is possible to affirm that MS has a strong impact on patients' employment status, as the mean unemployment rate was 59%. Research on factors promoting maintenance of remunerative employment is required.

EDITORIAL: MST Best Paper Award for 2004

NASA Astrophysics Data System (ADS)

Gill, Patrick

2005-12-01

For the last 13 years, Measurement Science and Technology has awarded a Best Paper prize. The Editorial Board of the journal believes that such a prize is an opportunity to thank authors for submitting their work, and serves as an integral part of the on-going quality review of the journal. An Editorial Board working party, comprising Patrick Gill (Chairman), David Birch and Ralph Tatam undertook the task of selecting as Best Paper 2004 a single contributed paper describing new and significant work, well aligned with the measurement scope of the journal, and presented in clear and rigorous form. They received a number of recommendations from the Editorial and International Advisory Board Members, and they would like to record their thanks to the Members for these recommendations, as they form an all-important first stage in the assessment process. There were responses from some five Board Members. In total, there were 16 papers nominated, plus another six from the working party. All these papers had quality ratings of 2 or higher from the referees, and note was also taken of the total electronic accesses for those papers subsequently short-listed. Review Articles, and papers that included a Board Member as an author, were automatically excluded. From the submitted nominations and working party deliberations, a short list of two papers was drawn up. The winning paper was then selected on the totality of criteria. Thus the paper recommended by the working party for the MST Best Paper Award for 2004 is: 'Adsorptive pressure-sensitive coatings on porous anodised aluminium' by Masaharu Kameda, Norikazu Tezuka, Tomohiro Hangai, Keisuke Asai, Kazuyuki Nakakita and Yutaka Amao, 15 489-500 (2004) This paper describes a novel pressure sensor based on a luminescent coating applied to a porous anodized aluminium layer, with application to the measurement of fluctuating pressures on short timescales with high spatial resolution. The research has particular application to pressure and flow measurements on aircraft structures in wind tunnels. The luminescence from the molecular sensor can be quenched by oxygen, giving a luminescence intensity inversely proportional to quencher concentration and hence air pressure. Quenching occurs on the 10 µs timescale, allowing use in unsteady pressure measurement situations. The paper is well organized and clearly written, with a good introduction to the principle of the sensor technique and its application, together with a clear description of the techniques needed to produce good sensitivity by means of luminophore adsorption to enhanced surface area offered by porous anodized aluminium. The paper considers theoretical aspects of the sensor time response, both in respect of luminescence lifetime and also gas permeation in a micropore. The experimental responses for two types of pressure fluctuation are presented. These include a pressure-jump apparatus by means of a fast opening valve on the millisecond timescale, and a shock tube system capable of microsecond resolution using a CCD array. In addition, coating intensity versus pressure and temperature relations, together with photodegradation, have been studied. Thus the paper reports a good combination of multidisciplinary activities necessary to develop and test a simple sensor capable of widespread application. The paper cites up-to-date references to prior art, has a good quality rating from the referees and significant downloads. We therefore recommend this paper for the MST 2004 Best Paper Award. The paper that came a close second was 'Micromachined strain gauges for the determination of liquid flow friction coefficients in microchannels' by R Baviere and F Ayela, 15 377-383 (2004)

Creating High-Quality Health Care Workplaces. A Background Paper for Canadian Policy Research Networks' National Roundtable (Ottawa, Ontario, Canada, October 29, 2001). CPRN Work Network Discussion Paper.

ERIC Educational Resources Information Center

Koehoorn, Mieke; Lowe, Graham S.; Rondeau, Kent V.; Schellenberg, Grant; Wagar, Terry H.

Insights from a variety of research streams were synthesized to identify the key ingredients of a high-quality work environment in Canada's health care sector and ways of achieving high-quality workplaces in the sector. The following sets of interacting factors were considered: (1) the work environment and the human resource practices that shape…

Manned Mars missions: A working group report

NASA Technical Reports Server (NTRS)

Duke, Michael B. (Editor); Keaton, Paul W. (Editor)

1986-01-01

The discussions of the Working Group (based in large part on working papers, which will shortly be published separately) are summarized. These papers cover a broad range of subjects which need to be addressed in the formulation of such a formidable enterprise as a manned Mars program. Science objective and operations; Mars surface infrastructure and activities; mission and system concepts and configurations; life sciences; impacts on the space infrastructure; and costs, schedules, and organizations are addressed.

Teleconferencing; A Bibliography.

ERIC Educational Resources Information Center

Weber, Dianne, Comp.

A bibliography lists works on two-way electronic conferencing, as well as several general works on telecommunications. It is in three parts. The record identifications (RECID) index is a list of 168 references to books, parts of books, journal articles, conference papers, news items, and unpublished papers. The author index relists the entire…

When Is It OK to Learn at Work? The Learning Work of Organisational Practices

ERIC Educational Resources Information Center

Scheeres, Hermine; Solomon, Nicky; Boud, David; Rooney, Donna

2010-01-01

Purpose: The purpose of this paper is to examine the use of "learning" through what we have termed "integrated development practices". These are common organisational practices that both enhance organisational effectiveness and contribute to organisational and employee learning. Design/methodology/approach: The paper analyses…

Facilitating Student Learning through Contextualization. CCRC Working Paper No. 29

ERIC Educational Resources Information Center

Perin, Dolores

2011-01-01

This paper is a literature review that explores the nature and effectiveness of contextualization as a way to improve outcomes for academically underprepared college students. Two forms of contextualization have been studied: "contextualized" and "integrated" instruction. There is more descriptive work on the contextualization of basic skills than…

Lacan, Subjectivity and the Task of Mathematics Education Research

ERIC Educational Resources Information Center

Brown, Tony

2008-01-01

This paper addresses the issue of subjectivity in the context of mathematics education research. It introduces the psychoanalyst and theorist Jacques Lacan whose work on subjectivity combined Freud's psychoanalytic theory with processes of signification as developed in the work of de Saussure and Peirce. The paper positions Lacan's subjectivity…

Grammar and the Lexicon. Working Papers in Linguistics 16.

ERIC Educational Resources Information Center

University of Trondheim Working Papers in Linguistics, 1993

1993-01-01

In this volume, five working papers are presented. "Minimal Signs and Grammar" (Lars Hellan) proposes that a significant part of the "production" of grammar is incremental, building larger and larger constructs, with lexical objects called minimal signs as the first steps. It also suggests that the basic lexical information in…

University of New Mexico Working Papers in Linguistics, Volume 1.

ERIC Educational Resources Information Center

Meehan, Teresa M., Ed.; Schwenter, Scott A., Ed.

This volume contains working papers on a variety of topics in linguistics. They include: "A View of Phonology from a Cognitive and Functional Perspective" (Joan Bybee); "The Geography of Language Shift: Distance from the Mexican Border and Spanish Language Claiming in the Southwestern United States" (Garland D. Bills, Eduardo…

How to Work Effectively with Alumni Boards.

ERIC Educational Resources Information Center

Alberger, Patricia L., Ed.

Perspectives on working with alumni boards are presented in papers presented at a 1980 conference sponsored by the Council for the Advancement and Support of Education. Papers and authors are as follows: "Your Alumni: An Untapped Resource," Robert G. Forman; "Involving your Alumni in the Total Alumni Program," Douglas Wilson;…

Understanding Quality of Working Life of Workers with Intellectual Disabilities

ERIC Educational Resources Information Center

Flores, Noelia; Jenaro, Cristina; Orgaz, M. Begona; Martin, M. Victoria

2011-01-01

Background: This paper examines the perceived quality of working life of workers with intellectual disabilities. Specifically, this paper looks at participants' perceptions in relation to perceived job demands and resources and their impact on experienced job satisfaction. Methods: In this cross-sectional survey, 507 workers with intellectual…

Working To Learn: Transforming Learning in the Workplace.

ERIC Educational Resources Information Center

Evans, Karen, Ed.; Hodkinson, Phil, Ed.; Unwin, Lorna, Ed.

This book contains 13 papers on transformations in the nature of work that affect the learning and skill requirements of jobs and individuals and ways those requirements can be met. The following papers are included: "The Significance of Workplace Learning for a 'Learning Society'" (Karen Evans, Helen Rainbird); "Learning Careers:…

34 CFR 668.23 - Compliance audits and audited financial statements.

Code of Federal Regulations, 2011 CFR

2011-07-01

...” refers to an independent certified public accountant or a government auditor. To conduct an audit under... to records, audit work papers, or other documents necessary to review that audit, including the right to obtain copies of those records, work papers, or documents. (2) An institution must give the...

34 CFR 668.23 - Compliance audits and audited financial statements.

Code of Federal Regulations, 2013 CFR

2013-07-01

...” refers to an independent certified public accountant or a government auditor. To conduct an audit under... to records, audit work papers, or other documents necessary to review that audit, including the right to obtain copies of those records, work papers, or documents. (2) An institution must give the...

34 CFR 668.23 - Compliance audits and audited financial statements.

Code of Federal Regulations, 2014 CFR

2014-07-01

...” refers to an independent certified public accountant or a government auditor. To conduct an audit under... to records, audit work papers, or other documents necessary to review that audit, including the right to obtain copies of those records, work papers, or documents. (2) An institution must give the...

34 CFR 668.23 - Compliance audits and audited financial statements.

Code of Federal Regulations, 2012 CFR

2012-07-01

...” refers to an independent certified public accountant or a government auditor. To conduct an audit under... to records, audit work papers, or other documents necessary to review that audit, including the right to obtain copies of those records, work papers, or documents. (2) An institution must give the...

Work Papers of the Summer Institute of Linguistics, University of North Dakota Session. Volume 41.

ERIC Educational Resources Information Center

Marlett, Stephen A., Ed.

The collection of seven working papers in linguistics includes: "Proceeding from Syllable Inventory to Phonemic Inventory in the Analysis of Liangshan Yi (Andy Eatough); "Empty Consonants in Root-Medial Position" (Stephen A. Marlett); "What Is Literature? A Definition Based on Prototypes" (Jim Meyer); "Seri…

7 CFR 305.6 - Cold treatment requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) The cold treatment facility must remain locked during non-working hours. (v) Black light or sticky... hours. (vi) Black light or sticky paper must be used within the cold treatment facility, and other... remain locked during non-working hours. (viii) Black lights or sticky paper must be used within the cold...

Paper and Other Web Coating Maximum Achievable Control Technology (MACT): Work Practice, Testing, Monitoring, Recordkeeping, and Reporting Summary Table

EPA Pesticide Factsheets

This April 2004 document is a table that details the various requirements of the Paper and Other Web Coating NESHAP, broken down by category. This table covers applicability, recordkeeping, emission limits, work practice standards, and other requirements

Building Self: Adolescent Girls and Self-Esteem. Working Paper 2.

ERIC Educational Resources Information Center

Flansburg, Sundra

This working paper explores current thinking about self-esteem in adolescent girls in a pluralistic or multicultural society. A large percentage of current discussion and research on gender, adolescence, and self-esteem overlooks the diversity among females and neglects to analyze how various identities interweave with gender and strongly…

Women and Work. Exploring Race, Ethnicity, and Class. Women and Work, Volume 6.

ERIC Educational Resources Information Center

Higginbotham, Elizabeth, Ed.; Romero, Mary, Ed.

This book contains 10 papers exploring the effects of race, ethnicity, and class on women in the workplace. The following papers are included: "Series Editors' Introduction" (Ann Stromberg, Barbara A. Gutek, Laurie Larwood); "Introduction" (Elizabeth Higginbotham). The book is organized in four parts. Part I, "Historical…

Management Training in Educational Systems.

ERIC Educational Resources Information Center

Valle, Victor M.

The purpose of this paper is to provide a theoretical and experiential background for a better approach to the question "What are the learning needs in management training for personnel working at the management level within ministries of education?" The paper reviews the literature on management training for personnel working in…

Work Papers of the Summer Institute of Linguistics, University of North Dakota Session. Volume 35.

ERIC Educational Resources Information Center

Dooley, Robert A., Ed.; Quakenbush, J. Stephen, Ed.

The working papers by students and professors of linguistics on research in progress include the following: "Are Cariban Languages Moving Away From or Towards Ergative Systems?" (Desmond D. Derbyshire); "A Double-Verb Construction in Mbya Guarani" (Robert A. Dooley); "Semantically Ergative Languages in Typological…

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

Focusing on Staff Development and Administrative Issues.

ERIC Educational Resources Information Center

Kolvitz, Marcia, Ed.

These four conference papers from the Biennial Conference on Postsecondary Education for Persons who are Deaf or Hard of Hearing focus on staff development and administrative issues for postsecondary personnel working with students with deafness or who are hard of hearing. The first paper, "Mentorship for the Working Interpreter"…

NASA scheduling technologies

NASA Technical Reports Server (NTRS)

Adair, Jerry R.

1994-01-01

This paper is a consolidated report on ten major planning and scheduling systems that have been developed by the National Aeronautics and Space Administration (NASA). A description of each system, its components, and how it could be potentially used in private industry is provided in this paper. The planning and scheduling technology represented by the systems ranges from activity based scheduling employing artificial intelligence (AI) techniques to constraint based, iterative repair scheduling. The space related application domains in which the systems have been deployed vary from Space Shuttle monitoring during launch countdown to long term Hubble Space Telescope (HST) scheduling. This paper also describes any correlation that may exist between the work done on different planning and scheduling systems. Finally, this paper documents the lessons learned from the work and research performed in planning and scheduling technology and describes the areas where future work will be conducted.

How authors did it - a methodological analysis of recent engineering education research papers in the European Journal of Engineering Education

NASA Astrophysics Data System (ADS)

Malmi, Lauri; Adawi, Tom; Curmi, Ronald; de Graaff, Erik; Duffy, Gavin; Kautz, Christian; Kinnunen, Päivi; Williams, Bill

2018-03-01

We investigated research processes applied in recent publications in the European Journal of Engineering Education (EJEE), exploring how papers link to theoretical work and how research processes have been designed and reported. We analysed all 155 papers published in EJEE in 2009, 2010 and 2013, classifying the papers using a taxonomy of research processes in engineering education research (EER) (Malmi et al. 2012). The majority of the papers presented either empirical work (59%) or were case reports (27%). Our main findings are as follows: (1) EJEE papers build moderately on a wide selection of theoretical work; (2) a great majority of papers have a clear research strategy, but data analysis methods are mostly simple descriptive statistics or simple/undocumented qualitative research methods; and (3) there are significant shortcomings in reporting research questions, methodology and limitations of studies. Our findings are consistent with and extend analyses of EER papers in other publishing venues; they help to build a clearer picture of the research currently published in EJEE and allow us to make recommendations for consideration by the editorial team of the journal. Our employed procedure also provides a framework that can be applied to monitor future global evolution of this and other EER journals.

Geological Survey Research 1966, Chapter B

USGS Publications Warehouse

,

1966-01-01

This collection of 43 short papers is the first published chapter of 'Geological Survey Research 1966.' The papers report on scientific and economic results of current work by members of the Conservation, Geologic, Topographic, and Water Resources Divisions of the U.S. Geological Survey. Chapter A, to be published later in the year, will present a summary of significant results of work done during fiscal year 1966, together with lists of investigations in progress, reports published, cooperating agencies, and Geological Survey offices. 'Geological Survey Research 1966' is the seventh volume of the annual series Geological Survey Research. The six volumes already published are listed below, with their series designations. Geological Survey Research 1960-Prof. Paper 400 Geological Survey Research 1961-Prof. Paper 424 Geological Survey Research 1962-Prof. Paper 450 Geological Survey Research 1963-Prof. Paper 475 Geological Survey Research 1964-Prof. Paper 501 Geological Survey Research 1965-Prof. Paper 525

Biomineralization Guided by Paper Templates.

PubMed

Camci-Unal, Gulden; Laromaine, Anna; Hong, Estrella; Derda, Ratmir; Whitesides, George M

2016-06-09

This work demonstrates the fabrication of partially mineralized scaffolds fabricated in 3D shapes using paper by folding, and by supporting deposition of calcium phosphate by osteoblasts cultured in these scaffolds. This process generates centimeter-scale free-standing structures composed of paper supporting regions of calcium phosphate deposited by osteoblasts. This work is the first demonstration that paper can be used as a scaffold to induce template-guided mineralization by osteoblasts. Because paper has a porous structure, it allows transport of O2 and nutrients across its entire thickness. Paper supports a uniform distribution of cells upon seeding in hydrogel matrices, and allows growth, remodelling, and proliferation of cells. Scaffolds made of paper make it possible to construct 3D tissue models easily by tuning material properties such as thickness, porosity, and density of chemical functional groups. Paper offers a new approach to study mechanisms of biomineralization, and perhaps ultimately new techniques to guide or accelerate the repair of bone.

Biomineralization Guided by Paper Templates

PubMed Central

Camci-Unal, Gulden; Laromaine, Anna; Hong, Estrella; Derda, Ratmir; Whitesides, George M.

2016-01-01

This work demonstrates the fabrication of partially mineralized scaffolds fabricated in 3D shapes using paper by folding, and by supporting deposition of calcium phosphate by osteoblasts cultured in these scaffolds. This process generates centimeter-scale free-standing structures composed of paper supporting regions of calcium phosphate deposited by osteoblasts. This work is the first demonstration that paper can be used as a scaffold to induce template-guided mineralization by osteoblasts. Because paper has a porous structure, it allows transport of O2 and nutrients across its entire thickness. Paper supports a uniform distribution of cells upon seeding in hydrogel matrices, and allows growth, remodelling, and proliferation of cells. Scaffolds made of paper make it possible to construct 3D tissue models easily by tuning material properties such as thickness, porosity, and density of chemical functional groups. Paper offers a new approach to study mechanisms of biomineralization, and perhaps ultimately new techniques to guide or accelerate the repair of bone. PMID:27277575

Women's collective constructions of embodied practices through memory work: Cartesian dualism in memories of sweating and pain.

PubMed

Gillies, Val; Harden, Angela; Johnson, Katherine; Reavey, Paula; Strange, Vicki; Willig, Carla

2004-03-01

The research presented in this paper uses memory work as a method to explore six women's collective constructions of two embodied practices, sweating and pain. The paper identifies limitations in the ways in which social constructionist research has theorized the relationship between discourse and materiality, and it proposes an approach to the study of embodiment which enjoins, rather than bridges, the discursive and the non-discursive. The paper presents an analysis of 25 memories of sweating and pain which suggests that Cartesian dualism is central to the women's accounts of their experiences. However, such dualism does not operate as a stable organizing principle. Rather, it offers two strategies for the performance of a split between mind and body. The paper traces the ways in which dualism can be both functional and restrictive, and explores the tensions between these two forms. The paper concludes by identifiying opportunities and limitations associated with memory work as a method for studying embodiment.

Working Papers in Art Education, 1981.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1981-01-01

Papers by graduate students, and occasionally papers from their mentors which establish a context for the student papers, are organized into four sections. Section 1, "Observation," includes two papers, "Observation Children at a Puppet Theater Performance" (Grace Johnson), and "Manipulations: Clay Construction" (Kim Spradling). Section 2,…

Fabrication of Lab-on-Paper Using Porous Au-Paper Electrode: Application to Tumor Marker Electrochemical Immunoassays.

PubMed

Ge, Shenguang; Zhang, Yan; Yan, Mei; Huang, Jiadong; Yu, Jinghua

2017-01-01

A simple, low-cost, and sensitive electrochemical lab-on-paper assay is developed based on a novel gold nanoparticle modified porous paper working electrode for use in point-of-care testing (POCT). Electrochemical methods are introduced for lab-on-paper based on screen-printed paper electrodes. To further improve specificity, performance, and sensitivity for point-of-care testing, a novel porous Au-paper working electrode (Au-PWE) is designed for lab-on-paper using growth of an interconnected Au nanoparticle (NP) layer on the surface of cellulose fibers in order to enhance the conductivity of the paper sample zone and immobilize the primary antibodies (Ab1). With a sandwich-type immunoassay format, Pd-Au bimetallic nanoparticles possessing peroxidase-like activity are used as a matrix to immobilize secondary antibodies (Ab2) for rapid detection of targets. This lab-on-paper based immunodevice is applied to the diagnosis of a cancer biomarker in clinical serum samples.

Working Hours Flexibility. Background Paper No. 30.

ERIC Educational Resources Information Center

Staines, Graham L.

Flexible work schedules offer the promise of a low-cost option for helping people manage work and family responsibilities. Alternative work schedules include part-time work, job sharing, work sharing, shiftwork, compressed work week, flexitime, and flexiplace. Flexitime is the most prevalent full-time flexible schedule and is second in prevalence…

Policy Approaches to Evaluation and Incentive Funding in U.S. and Mexican Higher Education. "Understanding the Differences": A Working Paper Series on Higher Education in the U.S. and Mexico. Working Paper #1.

ERIC Educational Resources Information Center

Ewell, Peter T.; Kent, Rollin

This paper explores efforts of Mexico and the United States to obtain a significant return on their investment in postsecondary education. The authors establish a context for comparison between Mexico and the United States and discuss the challenges and central policy dilemmas that each country faces in implementing the policy tools of evaluation…

Learning from Consumer-Oriented Review Efforts To Guide the Development of a System of Expert Panels To Identify and Share Promising and Exemplary Products and Programs. Working Papers. Volumes One and Two.

ERIC Educational Resources Information Center

Office of Educational Research and Improvement (ED), Washington, DC. Office of Reform Assistance and Dissemination.

These volumes contain working papers related to the development of the Office of Educational Research and Improvement (OERI) Facilitated System of Expert Panels. Introductory papers by Susan Klein, Michael Scriven, Sharon Bobbitt and Susan Klein, and Michael Scriven and Lois-ellin Datta (printed in both volumes) set the stage for the discussions…

NOSTOS: a paper-based ubiquitous computing healthcare environment to support data capture and collaboration.

PubMed

Bång, Magnus; Larsson, Anders; Eriksson, Henrik

2003-01-01

In this paper, we present a new approach to clinical workplace computerization that departs from the window-based user interface paradigm. NOSTOS is an experimental computer-augmented work environment designed to support data capture and teamwork in an emergency room. NOSTOS combines multiple technologies, such as digital pens, walk-up displays, headsets, a smart desk, and sensors to enhance an existing paper-based practice with computer power. The physical interfaces allow clinicians to retain mobile paper-based collaborative routines and still benefit from computer technology. The requirements for the system were elicited from situated workplace studies. We discuss the advantages and disadvantages of augmenting a paper-based clinical work environment.

Development of a Work Control System for Propulsion Testing at NASA Stennis

NASA Technical Reports Server (NTRS)

Messer, Elizabeth A.

2005-01-01

This paper will explain the requirements and steps taken to develop the current Propulsion Test Directorate electronic work control system for Test Operations. The PTD Work Control System includes work authorization and technical instruction documents, such as test preparation sheets, discrepancy reports, test requests, pre-test briefing reports, and other test operations supporting tools. The environment that existed in the E-Complex test areas in the late 1990's was one of enormous growth which brought people of diverse backgrounds together for the sole purpose of testing propulsion hardware. The problem that faced us was that these newly formed teams did not have a consistent and clearly understood method for writing, performing or verifying work. A paper system was developed that would allow the teams to use the same forms, but this still presented problems in the large amount of errors occurring, such as lost paperwork and inconsistent implementation. In a sampling of errors in August 1999, the paper work control system encountered 250 errors out of 230 documents released and completed, for an error rate of 111%.

New roles and challenges within the healthcare workforce: a Heideggerian perspective.

PubMed

Wilson, Anthea

2015-01-01

The purpose of this paper is to explore insights based on the phenomenology of Martin Heidegger, on the dynamic relationships between human experience and work roles. Drawing on the findings of a hermeneutic phenomenological study of nurse mentors, the topics of new roles and role challenges are explored, along with a consideration of their relevance to wider issues of workforce redesign. Heidegger's philosophy of Dasein, in particular his concepts of inauthentic and authentic self, provided an interpretational lens. This paper applies these philosophical concepts to challenges associated with a changing workforce. Concepts elaborating human existence as proposed by Heidegger may offer analytic structures for understanding shifts in the lived experience of a changing workplace. In particular, the concepts could help managers to explore the implications of introducing novel work roles or extending roles. The understanding gained can also extend to situations where work practices may need to be challenged. As work roles and skill mix undergo rapid shifts, this paper offers an original way of understanding the experience of work roles.

Benjamin's Angel of History and the Work of Mourning in Ethical Remembrance: Understanding the Effect of W.G. Sebald's Novels in the Classroom

ERIC Educational Resources Information Center

Joldersma, Clarence W.

2014-01-01

The paper develops a conceptual framework for understanding the work of ethical remembrance in the classroom. Using David Hansen's recent example of using Sebald's novels in his classroom to do the work or remembrance, the paper argues that the effect of Sebald's novels is best understood using Walter Benjamin's figure of the…

Working Papers in Art Education, 1983.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1983-01-01

Papers by graduate students, and occasionally papers from their mentors which establish a context for the student papers, are organized by sponsoring University. Student papers presented are: (1) "An Overview of the Development Stages in Children's Drawings" (Jeralyn Hufford); (2) "Theories and Activities of Conceptual Artists: An Aesthetic…

Working Papers in Art Education, 1985.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1985-01-01

Papers by graduate students, and occasionally papers from their mentors which establish a context for the student papers, are organized by sponsoring University. Student papers presented are: (1) "Cognitive Strategy in Design: The Measurement of its Effect On the Student Design Project" (Michael Eckersley); (2) "The Effects of…

Geological Survey research 1962: Short papers in geology, hydrology, and topography: Articles 180-239

USGS Publications Warehouse

,

1963-01-01

This collection of 60 short papers on subjects in the fields of geology, hydrology, topography, and related sciences is the last of a series released as chapters of Professional Paper 450. The papers in this chapter report on the scientific and economic results of current work by members of the Conservation, Geologic, Topographic, and Water Resources Divisions of the United States Geological Survey. Some of the papers announce new discoveries or present observations on problems of limited scope; other papers draw conclusions from more extensive or continuing investigations that in large part will be discussed in greater detail in reports to be published in the future.Chapter A of this series presents a synopsis of results from a wide range of work done during the 1962 fiscal year.

Linking School and Work: Roles for Standards and Assessment. First Edition.

ERIC Educational Resources Information Center

Resnick, Lauren B., Ed.; Wirt, John G., Ed.

This book contains 12 papers commissioned by the Secretary's Commission for Achieving Necessary Skills (SCANS) to develop the SCANS recommendations concerning the role of standards and assessment in the transition from school to work. "The Changing Workplace" (Lauren B. Resnick, John G. Wirt) offers a summary of the 12 papers.…

Educational Decentralization and Behavior Change Needs in Indonesia. Working Paper.

ERIC Educational Resources Information Center

Cohen, Joseph

This working paper examines behavior change as a key element in creating an enabling environment to sustain educational reform in Indonesia. It recommends elevating the importance of a formalized behavior change framework and methodology so that future plans for educational reform in Indonesia will include social marketing as a planned…

Work-Based Research Degrees: Systematic Cultivation through a University-Industry Network Space

ERIC Educational Resources Information Center

Sense, Andrew J.

2016-01-01

The purpose of this paper is to expound on an innovative approach to cultivating work-based Doctorates and Masters of Philosophy degrees, which involves close collaboration between industry organisations and a tertiary institution. This paper also reports on an examination of the programme's structural ability to help develop the learning…

Career Frontiers: New Conceptions of Working Lives.

ERIC Educational Resources Information Center

Peiperl, Maury A., Ed.; Arthur, Michael B., Ed.; Goffee, Rob, Ed.; Morris, Timothy, Ed.

This book draws upon and extends a number of existing debates in the area of careers and opens additional dialogues on the future of working life. The book contains 13 papers, organized in three parts and an Introduction. The Introduction contains one paper, "Topics for Conversation: Career Themes Old and New" (Maury A. Peiperl and…

Transgressive vs Conformative: Immigrant Women Learning at Contingent Work

ERIC Educational Resources Information Center

Maitra, Srabani; Shan, Hongxia

2007-01-01

Purpose--The paper seeks to explore workers' learning in relation to the racialized and gendered organization of contingent work. Design/methodology/approach--This paper is informed by Marxist theorization of labour power and learning. It draws on the interview data of 24 highly educated immigrant women from the research project "Skilled In…

Pathfinders: Making a Way from Segregation to Community Life.

ERIC Educational Resources Information Center

O'Brien, Connie Lyle; Mount, Beth; O'Brien, John; Rosen, Fredda

This paper describes the Pathfinders program in New York (New York), which works to facilitate the full integration of adults with developmental disabilities into workplaces and neighborhoods. The paper is organized around the question of whether students graduating from special education can find paid and volunteer work in community settings,…

47 CFR 61.38 - Supporting information to be submitted with letters of transmittal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... economic information to support the changed or new matter. (1) For a tariff change the carrier must submit... located in the respective zones, and receive approval of its proposed plan. (c) Working papers and... previously offered, the Chief, Pricing Policy Division must be provided two sets of working papers containing...

Public Service Professionalism among State Administrators: A Multiple State Study. A Working Paper.

ERIC Educational Resources Information Center

Rose, Bruce J.; And Others

This working paper, part of an ongoing national study, presents preliminary analysis of public service professionalism among state public administrators in many states on the basis of data already produced by a continuing survey research project. Information about the data source and sample profiles are provided. Additionally, the research…

Negotiating the Curriculum. Tutors and Students. Coombe Lodge Working Paper. Information Bank Number 1968.

ERIC Educational Resources Information Center

Brace, Diane

This working paper presents guidelines for negotiating learning contracts between tutors and postsecondary students enrolled in a vocational program. The first two sections discuss the general rationale for negotiating curricula and the specific benefits of conducting such negotiations with students over the age of 16. Addressed next is the…

Public Welfare and Work Incentives: Theory and Practice. Studies in Public Welfare. Paper No. 14.

ERIC Educational Resources Information Center

Burke, Vee; Townsend, Alair A.

This chart book summarizes two volumes in the subcommittee's series, "Studies in Public Welfare." Paper No. 4 (Dec. 22, 1972) explored work incentive and disincentive features in existing and proposed public welfare programs (cash welfare, unemployment insurance, social security, veterans' benefits, food stamps, public housing, and medicaid).…

Anthropology and International Business. Studies in Third World Societies. Publication Number Twenty-Eight.

ERIC Educational Resources Information Center

Serrie, Hendrick, Ed.

The range and possibilities of "business anthropology" are explored in fourteen papers. The papers are presented in an order designed to illustrate five major roles for anthropologists interested in working with business: (1) conducting cross-cultural orientation programs for business personnel working in foreign countries or with different…

Learning and Recognition in Health and Care Work: An Inter-Subjective Perspective

ERIC Educational Resources Information Center

Liveng, Anne

2010-01-01

Purpose: The purpose of this paper is to discuss the role of recognition in learning processes among female nurses, social and health care assistants and occupational therapists working with people with dementia and other age-related illnesses. Design/methodology/approach: The paper highlights the need to experience recognizing learning spaces…

Do Financial Education Programs Work? Working Paper 08-03

ERIC Educational Resources Information Center

Hathaway, Ian; Khatiwada, Sameer

2008-01-01

In this paper we provide a comprehensive critical analysis of research that has investigated the impact of financial education programs on consumer financial behavior. In light of the evidence, we recommend that future programs be highly targeted towards a specific audience and area of financial activity (e.g. home-ownership or credit card…

1988 Work Papers of the Summer Institute of Linguistics, University of North Dakota Session. Volume 32.

ERIC Educational Resources Information Center

Derbyshire, Desmond C., Ed.

Six working papers in linguistics are presented. "The Semantics and Morphology of Mixtec Mood and Aspect" (J. Albert Bickford and Stephen A. Marlett) presents a relatively detailed description of the following grammatical categories in three Mixtec languages: Santiago Nuyoo, Santo Domingo Nuxaa, and Municipio of Tezoatlan.…

The Design and Management of an Organisation's Lifelong Learning Curriculum

ERIC Educational Resources Information Center

Dealtry, Richard

2009-01-01

Purpose: The purpose of this paper is to examine the successful design and management of high performance work-based lifelong learning processes. Design: The paper summarises the process management practices and contextual parameters that are being applied in the successful design and management of high performance work based lifelong learning…

UNIVERSALITY AND EVOLUTION OF BASIC COLOR TERMS. WORKING PAPER NUMBER 1.

ERIC Educational Resources Information Center

BERLIN, BRENT; KAY, PAUL

THE RESEARCH REPORTED IN THIS WORKING PAPER "STRONGLY INDICATES" THAT SEMANTIC UNIVERSALS HAVE BEEN DISCOVERED IN THE DOMAIN OF COLOR VOCABULARY. MOREOVER, THESE UNIVERSALS APPEAR TO BE RELATED TO THE HISTORICAL DEVELOPMENT OF ALL LANGUAGES IN A WAY THAT CAN PROPERLY BE TERMED EVOLUTIONARY. THE RESEARCH WAS CONDUCTED IN A GRADUATE…

Developments with the Commission's Longitudinal Student Data System. Working Paper WP/06-07

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2006

2006-01-01

This paper summarizes the many uses of the California Postsecondary Education Commission's data system and describes work in progress on adding additional data elements. It describes how the Commission is using its Longitudinal Student Data System (LSDS) to examine the movement of students through California's public colleges and universities. The…

'Right-to-Work' Laws and Economic Development in Oklahoma. Briefing Paper.

ERIC Educational Resources Information Center

Mishel, Lawrence, Ed.

The bulk of this position paper consists of statements in opposition to a September 2001 referendum on adopting 'right-to-work' (RTW) legislation in Oklahoma. The statements are by Joan Fitzgerald, William Sschweke, Raymond Hogler, Steven Shulman, Stephan Weiler, Ann Markusen, Robert G. Lynch, David R. Howell, James Galbraith, Colin Gordon, Wim…

Experiencing the Workplace: Shaping Worker Identities through Assessment, Work and Learning

ERIC Educational Resources Information Center

Timma, Hilary

2007-01-01

This paper explores how worker identities are shaped (and reshaped) in the workplace through the interconnected experiences of assessment, work and learning. Drawing on a study conducted at three food production companies in regional Victoria, the paper locates these workplace experiences as social constructions and considers the significance of…

Assessment of Online Discussion in Work-Integrated Learning

ERIC Educational Resources Information Center

McNamara, Judith; Brown, Catherine

2009-01-01

Purpose: The purpose of this paper is to examine how online discussion can be used in work-integrated learning as a vehicle for students to demonstrate their learning in the workplace and to facilitate collaborative learning where face-to-face classes are not feasible. Design/methodology/approach: The paper evaluates the use of assessable online…

Media Work and the Creative Industries: Identity Work, Professionalism and Employability

ERIC Educational Resources Information Center

Ashton, Daniel

2011-01-01

Purpose: The purpose of this paper is to examine the situated understandings that higher education students can offer on their employability, and to make sense of "employability" in industry and career context-specific ways. The paper further seeks to explore potential critical reflections on emerging professional practice and future…

Understanding Responsive Web Design in Higher Education. ECAR Working Group Paper

ERIC Educational Resources Information Center

Bollens, Eric; Rocchio, Rosemary A.; Peterson, Jill Eleanor; Pollack, Brett; Tirpak, Lori; Ward, Christopher Matthew

2014-01-01

This paper is a publication of the EDUCAUSE Center for Analysis and Research (ECAR) Mobile Strategy and Application Development (MSAD) Working Group. In higher education, nearly every user interaction that takes place on a desktop or laptop browser is also attempted using phones, tablets, watches, and more. As students, faculty, and staff…

African Diaspora Movement Arts in Philadelphia: A Beginning Resource List. Philadelphia Folklore Project Working Papers #10.

ERIC Educational Resources Information Center

Brown-Danquah, Benita Binta

This guide provides history, format, contact names, addresses, and phone numbers of some African dance and African American marching units in Philadelphia (Pennsylvania). The working papers are divided into two categories. "Part One: Movements of African Dance in Philadelphia" begins with a sensitive, detailed explanation of the…

2010 Profile of a Research Administrator

ERIC Educational Resources Information Center

Shambrook, Jennifer; Roberts, Thomas J.

2011-01-01

This paper expands upon the seminal work of Roberts and House, which described the first empirical study of the demographic profile of a research administrator. The original work was based upon data from the 2005 Research Administrator Survey (RAS), a regional study of research administrators in the southeastern United States. In this paper,…

Finance Project. Status Report and Preliminary Working Papers.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Office of the Chancellor.

This status report outlines the progress of the California Community College Finance Project. Working papers, models, and alternative proposals are reviewed in four areas: mission and function, finance, governance, and management. Priorities in mission and function are stated in terms of the characteristics and educational needs of the nearly 1.3…

Science, Philosophy & Religion. Working Papers Series Volume 1.

ERIC Educational Resources Information Center

Schenck, David, Ed.

Lehigh University Technology Studies Resource Center has coordinated and produced a series of publications that focus on expanding an understanding of the social context of technology in contemporary society. This volume is the first in a series of working papers that aim to stimulate new research, facilitate dissemination, encourage peer review,…

Occupational Adaptability and Educational Policy: Missing Links Between Working and Learning.

ERIC Educational Resources Information Center

Faddis, Constance; And Others

Intended for use by policymakers, program designers, researchers, and others concerned about education and employment outcomes, this collection of papers explores policy-relevant implications of occupational adaptability for the worlds of school and work. The first paper provides an overview of the concepts of change, adaptation, and the American…

Making Pathways: Young People and Their Informal Vocational Learning. Discussion Paper. Working Paper.

ERIC Educational Resources Information Center

Bye, Jayne

Current research into youth transitions in Australia documents an increasingly individualized process in which significant numbers of youths are deemed at risk of not making a successful transition from school to work. Many theorists are questioning the applicability of the linear model of transition to current conditions. Other theorists are…

Engaging with Employers in Work-Based Learning: A Foundation Degree in Applied Technology

ERIC Educational Resources Information Center

Benefer, Richard

2007-01-01

Purpose: This paper aims to describe the work of Staffordshire University in engaging with local employers and local further education colleges in the development of a Foundation Degree in Applied Technology. Design/methodology/approach: Following an outline of current government policy in employer engagement, the paper identifies--from the…

Key Policy Issues in the Implementation of User Choice. Working Paper No. 8.

ERIC Educational Resources Information Center

Smith, Joy Selby; Smith, Chris Selby; Ferrier, Fran

This working paper examines key policy issues in the implementation of Australia's User Choice policy regarding allocating public funds for vocational education and training (VET). Part 1 explains the process used to obtain stakeholders regarding the User Choice policy, the administrative arrangements required to support it, and issues that must…

Learning for Renewal; Learning in a Trade Union Practice

ERIC Educational Resources Information Center

Kopsen, Susanne

2011-01-01

Purpose: The purpose of this paper is to analyze learning in a Swedish trade union board in a workplace, according to contemporary challenges in working life and conditions, of decentralization and local independency of trade union work and learning. Design/methodology/approach: The paper is based on ethnographic studies of two Swedish local trade…

Research Data Storage: A Framework for Success. ECAR Working Group Paper

ERIC Educational Resources Information Center

Blair, Douglas; Dawson, Barbara E.; Fary, Michael; Hillegas, Curtis W.; Hopkins, Brian W.; Lyons, Yolanda; McCullough, Heather; McMullen, Donald F.; Owen, Kim; Ratliff, Mark; Williams, Harry

2014-01-01

The EDUCAUSE Center for Analysis and Research Data Management Working Group (ECAR-DM) has created a framework for research data storage as an aid for higher education institutions establishing and evaluating their institution's research data storage efforts. This paper describes areas for consideration and suggests graduated criteria to assist in…

Work Papers of the Summer Intitute of Linguistics, 1993. University of North Dakota Session, Volume 37.

ERIC Educational Resources Information Center

Dooley, Robert A., Ed.; Meyer, Jim, Ed.

This volume of work papers from the Summer Institute of Linguistics includes the following: "Goals and Indirect Objects in Seri" (Stephen A. Marlett); "Seri Kinship Terminology" (Mary B. Moser and Stephen A. Marlett); "Quiegolani Zapotec Phonology" (Sue Regnier); "Role and Reference Grammar" (Robert D. Van…

Work Papers of the 1990 Summer Institute of Linguistics, University of North Dakota Session. Volume 34.

ERIC Educational Resources Information Center

Dooley, Robert A.; Clifton, John

Five working papers in linguistics are presented. "Case Marking Strategies in Kope" (John Clifton) shows that there are different strategies followed by Kope for marking core as opposed to peripheral arguments, and discusses typological implications. In "Unmarked and Marked Instances of Topicalization in Hebrew" (Stephen H.…

Technology in Education, 1988. Working Papers of Planning and Development Research. Working Paper 88-2.

ERIC Educational Resources Information Center

Sharon, Donna

This report on technology in education has been prepared, primarily for TVOntario staff, to highlight new and growing educational applications and to summarize recent evaluations of earlier application efforts. The descriptions of trends and developments are classified by media format. Representative applications of the media include: (1)…

Intelligent transportation system (ITS) study for the Buffalo and Niagara Falls metropolitan area, Erie and Niagara Counties, New York : system architecture, working paper #5

DOT National Transportation Integrated Search

1997-06-18

This document has been prepared as part of the New York State Department of Transportation (NYSDOT) Buffalo and Niagara Falls Intelligent Transportation System Study. Working Paper #5 defines the conceptual system architecture that applies to the reg...

Factors Affecting College-Going Rates in California: A Study Prospectus. Working Paper WP/06-09

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2006

2006-01-01

This working paper announces a report proposed by the California Postsecondary Education Commission to conduct a further statistical study on the factors affecting college-going rates in California. These factors would include school demographics, neighborhood characteristics, and regional labor market forces. Such a study could reveal insights…

A Guide to Classical Liberal Scholarship. Revised Edition.

ERIC Educational Resources Information Center

Palmer, Tom G.

This booklet introduces students to a wide range of works of classical liberal scholarship. The works described can be used in researching term papers, theses, and dissertations; each book and article provides valuable insights and information that can make the difference between an "A" and a "B" paper. The tradition of classical liberalism…

Civilising the Natives? Liberal Studies in Further Education Revisited

ERIC Educational Resources Information Center

Simmons, Robin

2015-01-01

This paper uses Basil Bernstein's work on pedagogic discourses to examine a largely neglected facet of the history of vocational education--the liberal studies movement in English further education colleges. Initially, the paper discusses some of the competing conceptions of education, work and society which underpinned the rise and fall of the…

1987 Work Papers of the Summer Institute of Linguistics, University of North Dakota Session. Volume 31.

ERIC Educational Resources Information Center

Derbyshire, Desmond C., Ed.

Four working papers in linguistics are presented. "Basic Configurations of Pragmatic Structuring" (Robert A. Dooley) presents evidence for basic or unmarked pragmatic configurations in three Brazilian languages: Topic-Comment in Mbya Guarani, Comment-Topic in Hixkaryana, and Focus-Presupposition in Xavante. "The Syllable Structure…

Intelligent transportation system (ITS) study for the Buffalo and Niagara Falls metropolitan area, Erie and Niagara Counties, New York : transportation systems and deficiencies, working paper #1

DOT National Transportation Integrated Search

1997-06-18

This document has been prepared as part of the New York State Department of Transportation (NYSDOT) Buffalo and Niagara Falls Intelligent Transportation Systems Study. The primary objective of this working paper is to define and document transportati...

Becoming a Woman: Considerations in Educating Adolescents about Menstruation. Revised 1988. Working Paper No. 169.

ERIC Educational Resources Information Center

Stubbs, Margaret L.; And Others

This paper reports findings that have emerged from several studies conducted concerning young girls' and boys' attitudes toward menstruation. The research work discussed included: (1) cross-sectional data about menarcheal experience and about attitudes toward menstruation from early adolescent girls in grades six through nine; (2) cross-sectional…

Struggling with Involuntary Expressive Behaviours: Chinese Doctors' Professional Learning in Working Contexts

ERIC Educational Resources Information Center

Ma, Songge

2012-01-01

Purpose: This paper aims to explore what Chinese doctors have learned in authentic medical practice, what they want to learn, and the dynamics behind their professional learning in working contexts. Design/methodology/approach: The paper uses Narrative Inquiry, qualitative data which were collected by open-ended face-to-face interviews and…

Penn Working Papers in Educational Linguistics. Volume 7, Number 1, Spring 1991.

ERIC Educational Resources Information Center

Hardman, Joel, Ed.; And Others

Five working papers in linguistics and education are presented. "The Mediators: Providing Access To Texts in English in a Semi-Urban Maharashtrian College Community" (Grace Plamthodathil Jacob) examines the teacher's role in mediating cultural awareness as part of English second language education in a multilingual, non-western society.…

Neophilia Ranking of Scientific Journals.

PubMed

Packalen, Mikko; Bhattacharya, Jay

2017-01-01

The ranking of scientific journals is important because of the signal it sends to scientists about what is considered most vital for scientific progress. Existing ranking systems focus on measuring the influence of a scientific paper (citations)-these rankings do not reward journals for publishing innovative work that builds on new ideas. We propose an alternative ranking based on the proclivity of journals to publish papers that build on new ideas, and we implement this ranking via a text-based analysis of all published biomedical papers dating back to 1946. In addition, we compare our neophilia ranking to citation-based (impact factor) rankings; this comparison shows that the two ranking approaches are distinct. Prior theoretical work suggests an active role for our neophilia index in science policy. Absent an explicit incentive to pursue novel science, scientists underinvest in innovative work because of a coordination problem: for work on a new idea to flourish, many scientists must decide to adopt it in their work. Rankings that are based purely on influence thus do not provide sufficient incentives for publishing innovative work. By contrast, adoption of the neophilia index as part of journal-ranking procedures by funding agencies and university administrators would provide an explicit incentive for journals to publish innovative work and thus help solve the coordination problem by increasing scientists' incentives to pursue innovative work.

Sequential mathematical solution for authentication and authorization technique implementing encryption methodology creating secure transaction using various methods also at quantum level

NASA Astrophysics Data System (ADS)

Gharami, Snigdha; Dinakaran, M.

2017-11-01

We see challenges in authenticating each aspect of electronic usage, starting from transaction to social interaction the authenticity and availability of correct information is guided in various ways. Authentication and authorization follow one another; a process of authentication is calculated on multiple layers of steps. In this paper we discuss various possibilities of modifying and using ways to deal with authentication and authorization mechanism. Idea is to work through authentication with mathematical calculations. We will go through various scenarios and find out the system of information that fits best at the moment of need. We will take account of new approaches of authentication and authorization while working on mathematical paradigm of information. The paper also takes an eye on quantum cryptography and discusses on how it could help one in the present scenario. This paper is divided into sections discussing on various paradigm of authentication and how one can achieve it in secure way, this paper is part of research work where analysis of various constraints are to be followed in the extended research work.

A contemporary look at Hermann Hankel's 1861 pioneering work on Lagrangian fluid dynamics

NASA Astrophysics Data System (ADS)

Frisch, Uriel; Grimberg, Gérard; Villone, Barbara

2017-12-01

The present paper is a companion to the paper by Villone and Rampf (2017), titled "Hermann Hankel's On the general theory of motion of fluids, an essay including an English translation of the complete Preisschrift from 1861" together with connected documents [Eur. Phys. J. H 42, 557-609 (2017)]. Here we give a critical assessment of Hankel's work, which covers many important aspects of fluid dynamics considered from a Lagrangian-coordinates point of view: variational formulation in the spirit of Hamilton for elastic (barotropic) fluids, transport (we would now say Lie transport) of vorticity, the Lagrangian significance of Clebsch variables, etc. Hankel's work is also put in the perspective of previous and future work. Hence, the action spans about two centuries: from Lagrange's 1760-1761 Turin paper on variational approaches to mechanics and fluid mechanics problems to Arnold's 1966 founding paper on the geometrical/variational formulation of incompressible flow. The 22-year-old Hankel - who was to die 12 years later — emerges as a highly innovative master of mathematical fluid dynamics, fully deserving Riemann's assessment that his Preisschrift contains "all manner of good things."

Is There a Role for Publication Consultants and How Should Their Contribution be Recognized?

PubMed

Kendall, Graham; Yee, Angelina; McCollum, Barry

2016-10-01

When a scientific paper, dissertation or thesis is published the author(s) have a duty to report who has contributed to the work. This recognition can take several forms such as authorship, relevant acknowledgments and by citing previous work. There is a growing industry where publication consultants will work with authors, research groups or even institutions to help get their work published, or help submit their dissertation/thesis. This help can range from proof reading, data collection, analysis (including statistics), helping with the literature review and identifying suitable journals/conferences. In this opinion article we question whether these external services are required, given that institutions should provide this support and that experienced researchers should be qualified to carry out these activities. If these services are used, we argue that their use should at least be made transparent either by the consultant being an author on the paper, or by being acknowledged on the paper, dissertation or thesis. We also argue that publication consultants should provide an annual return that details the papers, dissertations and thesis that they have consulted on.

Doing more with less in nursing work: a review of the literature.

PubMed

Bradley, C

1999-09-01

The paper explores the literature on changes in nursing work. It examines the suggestion that changes in work practices are management responses to cost cutting imperatives. Nursing labour force issues such as staffing roles and staffing mix, the push for flexibility in the workforce and casualisation are discussed. The paper concludes that given the rise of casual work in the general Australian workforce, research needs to be conducted on the extent of casualisation of nursing, and the implications this may have for nursing practice, professional development and on the nursing labour market.

Encuentros esteticos deweyanos con la cultura popular anglofona en la ensenanza de ingles como lengua extranjera (EILE). Working Paper (Deweyan Aesthetic Encounters with Anglophone Popular Culture in the Teaching of English as a Foreign Language. Working Paper).

ERIC Educational Resources Information Center

Zoreda, Margaret Lee

This paper discusses how the introduction of Anglophone popular culture in the English-as-a-foreign-language class can serve to foster critical aesthetic experiences. It is argued that the popular culture of the hegemonic Anglophone countries is already part of students' lives and for that reason should be included in any critical Anglophone…

Experiencias interculturales y la pedagogia de la anglofonia en la ensenanza de ingles como lengua extranjera (EILE) desde una perspectiva deweyana. Working Paper (A Deweyan Perspective on Cross-Cultural Experiences and Anglophone Pedagogy in the Teaching of English as a Foreign Language. Working Paper).

ERIC Educational Resources Information Center

Zoreda, Margaret Lee

This paper discusses a framework for teaching English as a foreign language that incorporates significant cultural content and fosters critical encounters with Anglophone culture. It reviews relevant contemporary perspectives for understanding cross-cultural processes within the foreign language teaching environment with emphasis on the issue of…

Fraud prevention in paying portal

NASA Astrophysics Data System (ADS)

Sandhu, P. S.; Senthilkumar, N. C.

2017-11-01

The purpose of presenting this paper is to give the idea to prevent the fraud in finance paying portals as fraud is increasing on daily basis and mostly in financial sector. So through this paper we are trying to prevent the fraud. This paper will give you the working algorithm through which you can able to prevent the fraud. Algorithm will work according to the spending amount of the user, which means that use will get categories into one of the low, medium, high or very high category.

Analysis of Performance of Selected AFC, ATF Fuels, and Lanthanide Transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unal, Cetin; Galloway, Jack D.

2015-09-29

We started to look at the performance of ATF concept in LWRs late in FY14 and finish our studies in FY15. The work has been presented in AFC review meetings, ICAPP and TOPFUEL conferences. The final version of the work is accepted for publication in Nuclear Engineering and Science Journal (NES). The copy of ICAPP and NES papers are attached separately to this document as our milestone deliverables. We made an important progress in the modeling of lanthanide transport in FY15. This work produced an ANS Winter Meeting paper and GLOBAL 2015 paper. GLOBAL 2015 paper is also attached asmore » deliverable of FY15. The work on the lanthanide transport is preliminary. We are exploring other potential mechanisms, in addition to “liquid-like” diffusion mechanisms, proposed by Robert Mariani [1] before we analyze data that will be taken by Ohio State University. This year, we concentrate on developing diffusion kernels and principles of modeling. Next year, this work will continue and analyze the Ohio State data and develop approaches to solve multicomponent diffusion. In addition to three papers we attached to this report, we have done some research on coupling and the development of gas release model for metallic fuels in FY15. They are also preliminary in nature; therefore, we give the summary of what we found rather than an extended report that will be done in FY16.« less

Working Papers in Art Education, 1984.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1984-01-01

Papers by graduate students, and occasionally papers from their mentors which establish a context for the student papers, are organized by sponsoring University. Student papers presented are: (1) "The Relationship of Amount of Experience in Art to Visual Perception and Picture Memory" (Scott Wiley); (2) "In Pursuit of the Idea that…

Work-Family Conflict and Working Conditions in Western Europe

ERIC Educational Resources Information Center

Gallie, Duncan; Russell, Helen

2009-01-01

This article explores the influence of working conditions on work-family conflict (WFC) among married/cohabiting employees across seven European countries. Using data from the European Social Survey, the paper first investigates the role of working conditions relative to household level characteristics in mediating work-family conflict at the…

'I'm a bad mum': pregnant presenteeism and poor health at work.

PubMed

Gatrell, Caroline Jane

2011-02-01

This paper contributes to research on women's health by challenging the 'common belief' that pregnant employees are prone to take sick leave. Conversely, it shows how some pregnant employees are so determined to appear 'well' that they remain at work when they are ill. The paper coins the phrase 'pregnant presenteeism' to describe pregnant employees who resist taking sick leave. The paper first acknowledges previous studies which show how employers associate pregnancy with incompetence and sickness absence. It then examines why (in contrast to employers' assumptions), some pregnant employees remain at work when they are ill. It does this through a qualitative study of 15 employed mothers in the UK, each of whom was working in a managerial/professional role at the time of her interview. Of these 15 women, three remained at work during pregnancy despite serious health problems. In order to understand the experiences of these 'pregnant presentees', the paper draws upon Annandale and Clark's (1996) concept of a 'binary opposition' which articulates the tendency within medicine to polarize women's and men's health as if at opposite ends of a scale, with women's health classified as 'poor' and men's health as 'good'. The paper argues that the conceptual principles of 'binary opposition' spill over into workplace contexts especially in relation to pregnancy. It then proposes that some employed pregnant women deny their own ill health due to fear of being identified with the female, 'poor health' end of the binary opposition scale. It articulates such denial as a potentially serious health issue for pregnant workers. The paper develops new and more explicit links between 'socio-cultural' feminist studies on the employed maternal body, and health research. Copyright © 2010 Elsevier Ltd. All rights reserved.

Semicentennial tribute to the ingenious neurobiologist Christfried Jakob (1866-1956). 1. Works from Germany and the first Argentina period, 1891-1913.

PubMed

Triarhou, Lazaros C; del Cerro, Manuel

2006-01-01

This study, and the companion paper that follows, pays homage to the life and work of Christfried (also Christian or Christofredo) Jakob, a German-born neuropathologist who adopted Argentina as his country of vocation. Rated by von Economo and Koskinas among the three most important pre-1925 cortical neuro-anatomists, alongside Ramón y Cajal, Jakob is little known in the English literature. He has left an impressive record of publications, 30 richly illustrated monographs and 200 articles that span over a vast array of neurological themes, including cortical development and evolution, and the visceral brain. The present paper reviews works from his German years and the first visit to Argentina in 1899-1910. The companion paper covers his works (all in Spanish) during his 'second Argentina period', after 1913. Copyright (c) 2006 S. Karger AG, Basel.

Improving cardiac surgical care: a work systems approach.

PubMed

Wiegmann, Douglas A; Eggman, Ashley A; Elbardissi, Andrew W; Parker, Sarah Henrickson; Sundt, Thoralf M

2010-09-01

Over the past 50 years, significant improvements in cardiac surgical care have been achieved. Nevertheless, surgical errors that significantly impact patient safety continue to occur. In order to further improve surgical outcomes, patient safety programs must focus on rectifying work system factors in the operating room (OR) that negatively impact the delivery of reliable surgical care. The goal of this paper is to provide an integrative review of specific work system factors in the OR that may directly impact surgical care processes, as well as the subsequent recommendations that have been put forth to improve surgical outcomes and patient safety. The important role that surgeons can play in facilitating work system changes in the OR is also discussed. The paper concludes with a discussion of the challenges involved in assessing the impact that interventions have on improving surgical care. Opportunities for future research are also highlighted throughout the paper. 2010 Elsevier Ltd. All rights reserved.

Study of the ink-paper interaction by image analysis: surface and bulk inspection

NASA Astrophysics Data System (ADS)

Fiadeiro, Paulo T.; de O. Mendes, António; M. Ramos, Ana M.; L. de Sousa, Sónia C.

2013-11-01

In this work, two optical systems previously designed and implemented by our research team, were used to enable the surface and bulk inspection of the ink-paper interaction by image analysis. Basically, the first system works by ejecting micro-liter ink drops onto the papers surface while monitoring the event under three different views over time. The second system is used for sectioning the paper samples through their thickness and to simultaneously acquire images of the ink penetration of each section cut. In the performed experiments, three black inks of different brands and a common copy paper were chosen, used, and tested with the two developed optical systems. Both qualitative and quantitative analyses were carried out at the surface level and in the bulk of the paper. In terms of conclusions, it was shown that the three tested ink-paper combinations revealed very distinct characteristics.

Direct Desktop Printed-Circuits-on-Paper Flexible Electronics

PubMed Central

Zheng, Yi; He, Zhizhu; Gao, Yunxia; Liu, Jing

2013-01-01

There currently lacks of a way to directly write out electronics, just like printing pictures on paper by an office printer. Here we show a desktop printing of flexible circuits on paper via developing liquid metal ink and related working mechanisms. Through modifying adhesion of the ink, overcoming its high surface tension by dispensing machine and designing a brush like porous pinhead for printing alloy and identifying matched substrate materials among different papers, the slightly oxidized alloy ink was demonstrated to be flexibly printed on coated paper, which could compose various functional electronics and the concept of Printed-Circuits-on-Paper was thus presented. Further, RTV silicone rubber was adopted as isolating inks and packaging material to guarantee the functional stability of the circuit, which suggests an approach for printing 3D hybrid electro-mechanical device. The present work paved the way for a low cost and easygoing method in directly printing paper electronics.

A realist review of the partograph: when and how does it work for labour monitoring?

PubMed

Bedwell, Carol; Levin, Karen; Pett, Celia; Lavender, Dame Tina

2017-01-13

The partograph (or partogram) is recommended by the World Health Organisation (WHO), for monitoring labour wellbeing and progress. Concerns about limitations in the way the partograph is used in the clinical context and the potential impact on its effectiveness have led to this realist systematic review of partograph use. This review aimed to answer two key questions, 1) What is it about the partograph that works (or does not work); for whom does it work; and in what circumstances? 2) What are the essential inputs required for the partograph to work? A comprehensive search strategy encompassed key databases; including papers of varying methodologies. Papers were selected for inclusion if the focus of the paper was the partograph and related to context, mechanism or outcome. Ninety five papers were included for data synthesis. Two authors completed data extraction and synthesis. The evidence synthesis relates the evidence to identified theories of health worker acceptability, health system support, effective referral systems, human resources and health worker competence, highlighting barriers and facilitators. This first comprehensive realist synthesis of the partograph, provides the international community of maternity clinicians with a picture of potential issues and solutions related to successful labour recording and management, which is also translatable to other monitoring approaches.

Early variability in the conceptualisation of "sustainable development and human factors".

PubMed

Thatcher, Andrew

2012-01-01

The sub-discipline of "sustainable development and human factors" is relatively new, first being used in 2006 with a Technical Committee of the IEA being established only in 2009 and a similar special interest group on "green ergonomics" at the Institute of Ergonomics and Human Factors being established in 2010. In general though, the definitions and practice of "sustainable development" is highly contentious and ambiguous across a range of disciplines. This paper examines the diversity of definitions and approaches to sustainable development and human factors in the early papers in this sub-discipline. An examination of 45 chapters and papers (from 2008 to 2011) reveals a surprising consistency in the definitions used for sustainable development but also a large proportion of the papers where no definitions are given at all. The majority of papers were, however, biased towards an economic capital and social capital emphasis, which is to be expected of work traditionally in the ergonomics paradigm. Further, most papers were theoretical in nature demonstrating a great opportunity for empirical work. The variability in definitions is discussed in relation to the future challenges facing the growth of this emergent sub-discipline and opportunities for further theoretical and empirical work.

Space Technology Plasma Issues in 2001

NASA Technical Reports Server (NTRS)

Garrett, Henry (Editor); Feynman, Joan (Editor); Gabriel, Stephen (Editor)

1986-01-01

The purpose of the workshop was to identify and discuss plasma issues that need to be resolved during the next 10 to 20 years (circa 2001) to facilitate the development of the advanced space technology that will be required 20 or 30 years into the future. The workshop consisted of 2 days of invited papers and 2 sessions of contributed poster papers. During the third day the meeting broke into 5 working groups, each of which held discussions and then reported back to the conference as a whole. The five panels were: Measurements Technology and Active Experiments Working Group; Advanced High-Voltage, High-Power and Energy-Storage Space Systems Working Group; Large Structures and Tethers Working Group; Plasma Interactions and Surface/Materials Effects Working Group; and Beam Plasmas, Electronic Propulsion and Active Experiments Using Beams Working Group.

Three-dimensional paper-based electrochemiluminescence immunodevice for multiplexed measurement of biomarkers and point-of-care testing.

PubMed

Ge, Lei; Yan, Jixian; Song, Xianrang; Yan, Mei; Ge, Shenguang; Yu, Jinghua

2012-02-01

In this work, electrochemiluminescence (ECL) immunoassay was introduced into the recently proposed microfluidic paper-based analytical device (μPADs) based on directly screen-printed electrodes on paper for the very first time. The screen-printed paper-electrodes will be more important for further development of this paper-based ECL device in simple, low-cost and disposable application than commercialized ones. To further perform high-performance, high-throughput, simple and inexpensive ECL immunoassay on μPAD for point-of-care testing, a wax-patterned three-dimensional (3D) paper-based ECL device was demonstrated for the very first time. In this 3D paper-based ECL device, eight carbon working electrodes including their conductive pads were screen-printed on a piece of square paper and shared the same Ag/AgCl reference and carbon counter electrodes on another piece of square paper after stacking. Using typical tris-(bipyridine)-ruthenium (Ⅱ) - tri-n-propylamine ECL system, the application test of this 3D paper-based ECL device was performed through the diagnosis of four tumor markers in real clinical serum samples. With the aid of a facile device-holder and a section-switch assembled on the analyzer, eight working electrodes were sequentially placed into the circuit to trigger the ECL reaction in the sweeping range from 0.5 to 1.1 V at room temperature. In addition, this 3D paper-based ECL device can be easily integrated and combined with the recently emerging paper electronics to further develop simple, sensitive, low-cost, disposable and portable μPAD for point-of-care testing, public health and environmental monitoring in remote regions, developing or developed countries. Copyright © 2011 Elsevier Ltd. All rights reserved.

From Car Park to Children's Park: A Childcare Centre in Development. Working Papers in Early Childhood Development.

ERIC Educational Resources Information Center

Wunschel, Gerda

This working paper describes the development of a child care center in Berlin, Germany, focusing on how the program's pedagogical principles support children's learning, how respect for diversity is integrated in everyday practice, and how program quality and accessibility are defined within a multicultural context. Chapter 1 describes the…

Assessing Students with Disabilities and Limited English Proficiency. Working Paper Series. Working Paper No. 95-13.

ERIC Educational Resources Information Center

Houser, James

In recent assessments, the National Center for Education Statistics (NCES) has permitted schools to exclude some students with disabilities or limited English proficiency because it believed that its assessments would not accurately measure the ability and achievement levels of these students. The exclusion of a portion of students from…

School Social Work Interventions with Behaviorally Disordered Children: Practical Applications of Theory.

ERIC Educational Resources Information Center

McCullagh, James G., Ed.; McCullagh, Cheryl A., Ed.

The handbook, intended for school social workers and related services personnel in Iowa who work with behavior disordered students, consists of 21 papers organized into four sections. The first section provides an orientation to behavior disorders in two papers: "Behavioral Disorders in Iowa--An Overview" (Carl R. Smith and Jeff Grimes);…

Integration of Immigrants in OECD Countries: Do Policies Matter? OECD Economics Department Working Papers, No. 564

ERIC Educational Resources Information Center

Causa, Orsetta; Jean, Sebastien

2007-01-01

This working paper assesses the ease of immigrants' integration in OECD labour markets by estimating how an immigration background influences the probability of being active or employed and the expected hourly earnings, for given individual characteristics. Applying the same methodology to comparable data across twelve OECD countries, immigrants…

Sectorial Relations & Chicago School Reform: A Preliminary View from the Foundation Sector. A Working Paper.

ERIC Educational Resources Information Center

McKersie, William S.

Are sectorial relations among nonprofit organizations, business, and government truly dependent, or are they instead a complex mix of dependent and independent actions? This working paper is based on a dissertation in progress, which is a comparative analysis of how private foundations influence the reform of urban public education. It compares…

Mexican-Origin Women's Employment Instability. Working Paper No. 51.

ERIC Educational Resources Information Center

De Anda, Roberto M.

This paper compares the causes and consequences of employment instability among Mexican-origin women, White women, and White men. Data came from the work experience supplement in the March 1995 file of the Current Population Survey for a sample that included 1,399 Mexican-origin women, 17,092 White women, and 24,440 White men. All were experienced…

Developing Appropriate Workforce Skills for Australia's Emerging Digital Economy: Working Paper

ERIC Educational Resources Information Center

Gekara, Victor; Molla, Alemayehu; Snell, Darryn; Karanasios, Stan; Thomas, Amanda

2017-01-01

This working paper is the first publication coming out of a project investigating the role of vocational education and training (VET) in developing digital skills in the Australian workforce, using two sectors as case studies--Transport and Logistics, and Public Safety and Correctional Services. The study employs a mixed method approach, combining…

Big Data: Laying the Groundwork. ECAR Working Group Paper

ERIC Educational Resources Information Center

Almes, Guy T.; Hillegas, Curtis W.; Lance, Timothy; Lynch, Clifford A.; Monaco, Gregory E.; Mundrane, Michael R.; Zottola, Ralph J.

2014-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

Big Data in the Campus Landscape: Curation. ECAR Working Group Paper

ERIC Educational Resources Information Center

Lynch, Clifford A.

2015-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

Supplement to This School Works for Me: Creating Choices to Boost Achievement. A Guide for Data Analysts

ERIC Educational Resources Information Center

Bill & Melinda Gates Foundation, 2010

2010-01-01

This paper serves as a supplement to the "This School Works for Me: Creating Choices to Boost Achievement. A Guide for Data Analysts" report. This paper contains the following sections: (1) Initial Steps; (2) Developing Baseline District Facts; (3) Identifying Effective Options; (4) Identifying Effective Options: Preventative; and (5) Identifying…

Creativity, Group Pedagogy and Social Action: A Departure from Gough

ERIC Educational Resources Information Center

Evans, James; Cook, Ian; Griffiths, Helen

2008-01-01

The following paper continues discussions within this journal about how the work of Delueze and Guattari can inform radical pedagogy. Building primarily on Noel Gough's 2004 paper, we take up the challenge to move towards a more creative form of "becoming cyborg" in our teaching. In contrast to work that has focused on Deleuzian theories of the…

Jobs-Plus Site-by-Site: An Early Look at Program Implementation. A Jobs-Plus Working Paper.

ERIC Educational Resources Information Center

Bloom, Susan Philipson, Ed.

This working paper assembles chapters written by onsite researchers about program implementation in each of seven cities included in the Job-Plus Community Revitalization Initiative for Public Housing Families. This report, which provides a "snapshot" of each site, documents the nature and extent of implementation as of that point in…

Classroom Assessment in Mathematics: Views from a National Science Foundation Working Conference (Greensboro, North Carolina, May 16-18, 1997).

ERIC Educational Resources Information Center

Bright, George W., Ed.; Joyner, Jeane M., Ed.

This document presents papers from a National Science Foundation (NSF) working conference to identify research issues and implementation strategies that support quality classroom assessment. Papers include: (1) "Understanding and Improving Classroom Assessment: Summary of Issues Raised" (George W. Bright and Jeane M. Joyner); (2) "Recommendations…

College Students and Politics: A Literature Review. CIRCLE Working Paper 46

ERIC Educational Resources Information Center

Longo, Nicholas V.; Meyer, Ross P.

2006-01-01

In this working paper, the authors review the literature on college students' political attitudes and behaviors. It is hoped that this review will help to refine research questions and ultimately lead to a larger follow-up research study on college student political engagement. The literature review was based on the following three questions: (1)…

The Classroom-Kitchen Table Connection: The Effects of Political Discussion on Youth Knowledge and Efficacy. CIRCLE Working Paper #72

ERIC Educational Resources Information Center

Vercellotti, Tim; Matto, Elizabeth C.

2010-01-01

CIRCLE Working Paper #72 addresses whether efforts to systematically incorporate media into school curricula increases several elements of civic engagement, including students' media use, political knowledge or their sense of being able to understand and influence politics (internal political efficacy). In "The Classroom-Kitchen Table…

Natural language query system design for interactive information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Liu, I-Hsiung

1985-01-01

This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled Natural Language Query System Design for Interactive Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-17.

How to Publish Work in Indexed Scientific Journals--An Overview

ERIC Educational Resources Information Center

Suzic, Nenad

2017-01-01

This paper sets out to tackle the issue of the criteria which should be met prior to submission of papers to indexed scientific journals. Firstly, the author addresses the field of qualitative research and tries to define the general characteristics of such works, and secondly, some clarification is brought with respect to the imbalance between…

"Quality Circles": A Strategy for Personal and Curriculum Development. Coombe Lodge Working Paper. Information Bank Number 1803.

ERIC Educational Resources Information Center

Field, M. J.; Harrison, A. B.

Quality circles attempt to satisfy both task and personal needs through staff involvement in solving work-related problems. This paper summarizes quality circle theory, applies it to school settings, and suggests a framework for introducing the process to educational institutions. After briefly defining quality circles, the article presents two…

Getting People Involved: The Benefit of Intellectual Capital Management for Addressing HR Challenges

ERIC Educational Resources Information Center

Pook, Katja

2011-01-01

Purpose: This paper aims to explore the benefits of intellectual capital assessment for facing current challenges of human resources work and organizational development. Design/methodology/approach: The paper takes findings of studies on challenges in HR work and maps them with features of intellectual capital assessment methods. It is thus a…

Staff Development for Raising Attainment: A Practitioner's View of What Works

ERIC Educational Resources Information Center

Bates, Sharon; Watt, Laura

2016-01-01

This paper offers a practitioner's view of how continuing professional development (CPD) can help raise achievement in schools. It is one of four papers in this issue linked to a research project in Stoke-on-Trent seeking to raise attainment in schools in deprived communicates. Based on over 20 years' experience working in and with different…

Women in Working Class Ethnic Communities. "Controversial Issues Kit" No. 2.

ERIC Educational Resources Information Center

Risinger, C. Frederick

This kit provides a summary of a scholarly paper, discussion questions, and activities to promote constructive debate between scholars and ethnic groups about the role of women in working class ethnic communities. The paper identifies these women as descendants of immigrant women who still live in large industrial centers of the East and Midwest.…

Utilizing Alternative Assessment Techniques with Physically Impaired Students To Increase Work Completion and Improve Work Quality.

ERIC Educational Resources Information Center

Thomas, Traci L.

This paper describes a practicum project that involved teaching 14 students (ages 8 through 13) with physical disabilities (cerebral palsy, spina bifida, and muscular dystrophy) to plan, organize, and complete projects and assignments independently. The paper explains the low expectations for the students and the students' lack of experience in…

Understanding Works of Art, the Inexpressible, and Teaching: A Philosophical Sketch

ERIC Educational Resources Information Center

Richmond, Stuart

2010-01-01

Understanding is an elusive and little understood concept yet it is frequently cited as an educational aim. The aim of this paper is to illuminate the nature of understanding in the art education context. This paper explores critically the conceptual background of understanding, drawing on the work of Wittgenstein, to reveal its varied and…

What Works: Real Research or a Cherry Picker's Paradise?

ERIC Educational Resources Information Center

Dainton, Sheila

2006-01-01

The purpose of this article is to consider the evidence base for some of the proposals in the Education White Paper, Higher Standards: better schools for all. In particular, the article challenges the assertion by the Secretary of State for Education and Skills that the White Paper is based on knowledge of "what works." Using the issue…

The Science of Neglect: The Persistent Absence of Responsive Care Disrupts the Developing Brain. Working Paper 12

ERIC Educational Resources Information Center

National Scientific Council on the Developing Child, 2012

2012-01-01

Young children who experience severe deprivation or neglect can experience a range of negative consequences. Neglect can delay brain development, impair executive function skills, and disrupt the body's stress response. This working paper from the National Scientific Council on the Developing Child explains why neglect is so harmful in the…

School Safety in Urban Charter and Traditional Public Schools. NCSRP Working Paper # 2007-1

ERIC Educational Resources Information Center

Christensen, Jon

2007-01-01

This working paper discusses safety in urban charter schools relative to other urban public schools, using several indicators from the Schools and Staffing Survey (SASS). SASS is the nation's most extensive sample survey of elementary and secondary schools and the teachers and administrators who staff them. The indicators measure the frequency of…

Higher Education and American Competitiveness. Working Paper.

ERIC Educational Resources Information Center

Lynton, Ernest A.

This working paper reflects the conviction that three areas of change are needed if America's higher education system as a whole is to make optimal contributions to the economic health of the country; it is based on the premise that at this time higher education is far from fully contributing to the economic well-being of the United States. The…

Making Grading Work.

ERIC Educational Resources Information Center

Lotto, Edward; Smith, Bruce

Two teachers have developed a procedure for grading student compositions that seems fairer to both them and their students. The students are given a choice of which papers they wish to submit for grading, and when they do submit work, the papers are identified by a number only (chosen by the student and indexed in a class card file). Each teacher…

Science Teachers' Satisfaction: Evidence from the PISA 2015 Teacher Survey. OECD Education Working Papers, No. 168

ERIC Educational Resources Information Center

Mostafa, Tarek; Pál, Judit

2018-01-01

In 2015, for the first time in its history, PISA (the Programme for International Student Assessment) asked teachers to describe the various aspects of their working environment and teaching practices. This paper examines how teacher, student, and school characteristics are related to science teachers' satisfaction in 19 PISA-participating…

Supportive Relationships and Active Skill-Building Strengthen the Foundations of Resilience. Working Paper 13

ERIC Educational Resources Information Center

National Scientific Council on the Developing Child, 2015

2015-01-01

Science shows that children who do well despite serious hardship have had at least one stable and committed relationship with a supportive adult. These relationships buffer children from developmental disruption and help them develop "resilience," or the set of skills needed to respond to adversity and thrive. This working paper from the…

"Living on the Edge": A Case of School Reform Working for Disadvantaged Young Adolescents

ERIC Educational Resources Information Center

Smyth, John; McInerney, Peter

2007-01-01

This paper describes an instance of a disadvantaged (urban) Australian government school that realized it had little alternative but to try new approaches; "old ways" were not working. The paper describes an ensemble of school reform practices, philosophies and strategies that give young adolescents genuine ownership of their learning.…

The New Family Equality: Myth or Reality?

ERIC Educational Resources Information Center

Vanek, Joann

The paper analyzes the work roles of husbands and wives in the 1970s and suggests policies to implement sex equality in the workplace and at home. Data reviewed in the paper support the structural-cultural view that work behavior both inside and outside the home is shaped by deeply embedded cultural and structural forces. In 1975, 41% of families…

Work and Inertial Frames

ERIC Educational Resources Information Center

Kaufman, Richard

2017-01-01

A fairly recent paper resolves a large discrepancy in the internal energy utilized to fire a cannon as calculated by two inertial observers. Earth and its small reaction velocity must be considered in the system so that the change in kinetic energy is calculated correctly. This paper uses a car in a similar scenario, but considers the work done by…

"Learning to Work" in Small Businesses: Learning and Training for Young Adults with Learning Disabilities

ERIC Educational Resources Information Center

Ruggeri-Stevens, Geoff; Goodwin, Susan

2007-01-01

Purpose: The paper alerts small business employers to new dictates of the Disability Discrimination Act (2005) as it applies to learning disabilities. Then the "Learning to Work" project featured in the paper offers small business employers a set of approaches and methods for the identification of a learning-disabled young adult…

University Research and Economic Development in Arizona Today: A Working Paper.

ERIC Educational Resources Information Center

Fisher, Marvin

One of the working papers in the final report of the Arizona Board of Regents' Task Force on Excellence, Efficiency and Competitiveness, this study focuses on Arizona's university research and economic development. There is concern that America is losing its competitive edge in the crucial areas of science and technology as fewer students study…

Children's Work and Schooling: Does Gender Matter? Evidence from the Peru LSMS Panel Data. Working Paper.

ERIC Educational Resources Information Center

Ilahi, Nadeem

Using panel data from Peru, this paper investigates the determinants of the allocation of boys' and girls' time to schooling, housework, and income-generating activities. Specifically, it explores whether sickness, employment of adult women, infrastructure, and female headship have different impacts on the time use of boys and girls. Girls mostly…

Working Collectively to Design Online Teacher Education Curriculum: How Do Teacher Educators Manage to Do It?

ERIC Educational Resources Information Center

Milewski, Amanda; Gürsel, Umut; Herbst, Patricio

2017-01-01

This paper is part of a three-year inquiry that supports and investigates the work of groups of mathematics teacher educators using technological tools to design and implement multimedia practice-based teacher education curriculum materials. This paper describes the kinds of activities, interactions, and tools used by mathematics teacher educators…

Excellence at Work. Policy Option Papers for the National Governors' Association.

ERIC Educational Resources Information Center

Ganzglass, Evelyn, Ed.

This volume contains an introduction and four policy option papers that explore key issues affecting the economy and state options to address the issues within the context of the U.S. workplace. "Introduction" (David Bedford, Evelyn Ganzglass) discusses the issues identified in the first phase of the governors' initiative on Excellence at Work and…

Financial Measures Project. New Developments in Measuring Financial Conditions of Colleges and Universities: Papers Presented at a Working Conference.

ERIC Educational Resources Information Center

New York Community Trust, NY.

Papers presented at a working conference on new developments in measuring financial conditions of colleges and universities included the following: "Using Financial Indicators for Public Policy Purposes," by George W. Bonham; "Conceptual Advances in Specifying Financial Indicators: Cash Flows in the Short and Long Run," by Hans…

Education, Training and the Future of Work II: Developments in Vocational Education and Training.

ERIC Educational Resources Information Center

Flude, Mike, Ed.; Sieminski, Sandy, Ed.

This book contains 13 papers on developments in vocational education and training in Great Britain and the future of work. The following papers are included: "Introduction" (Geoff Esland, Mike Flude, Sandy Sieminski); "The Roles of the State and the Social Partners in Vocational Education and Training Systems" (Andy Green);…

Litera Scripta Manet--The Written Word Endures.

ERIC Educational Resources Information Center

McKenzie, Hope Bussey

Intended for college students and teachers of English literature, this paper examines the lives and works of three great medieval Anglo-Saxon priestly scholars whose Latin writings have preserved the Anglo-Saxon roots of the English language. The paper first describes the works of Aldhelm, born in 650 A.D., whose poetry was not in the Latin…

The Psychotherapy of Parenthood: Towards a Formulation and Valuation of Concurrent Work with Parents

ERIC Educational Resources Information Center

Sutton, Adrian; Hughes, Lynette

2005-01-01

This paper explores the process and value of concurrent work with parents when their child is being treated in individual psychotherapy. The position taken is that psychoanalytic understanding generally and the specific formulations presented in this paper have a broader applicability in other aspects and approaches in child and adolescent mental…

Reconsidering the Framework. Learning in Science Project. Working Paper No. 14.

ERIC Educational Resources Information Center

Osborne, Roger; And Others

The first working paper of the Learning in Science Project, "An Initial Framework," outlined what was then seen as the major aims of the project and suggested how these aims might be achieved by three phases of research: exploratory (to observe teaching/learning in Form 1 to 4 science classrooms and to identify difficulties perceived by…

Bridging the Skills Gap. Working Paper Part I: High Technology Industries.

ERIC Educational Resources Information Center

Kaplan, Christine E.

In this working paper on high technology industries, a few representative industries are studied in detail, while an overview is also given of the group as a whole. The overview, which highlights the findings of selected studies of the unique characteristics of high tech industries, considers such issues as locational factors, occupational and…

The Work of John Isaac Plummer at Orwell Park Observatory in the years 1874 to 1890

NASA Astrophysics Data System (ADS)

Whiting, P. J.

2006-12-01

This paper builds on the unpublished collation by the Orwell Astronomical Society entitled John Isaac Plummer. It takes the form of a chronology and critique of papers published by John Isaac Plummer (1844-1925) in the Monthly Notices of the Royal Astronomical Society and Astronomische Nachrichten on work undertaken at the Orwell Park Observatory, Ipswich, in the years 1874 to 1890. This work, mainly, although not exclusively, in England, took the form of measuring the positions and deriving the orbits of as many comets as could be observed from Orwell Park. Plummer also published papers in other journals, such as Nature and The Observatory, but these are to be the subject of future research.

The hypertensive response to intubation. Do researchers acknowledge previous work?

PubMed

Smith, A J; Goodman, N W

1997-01-01

To see whether investigators of a circumscribed research topic, the haemodynamic response to orotracheal intubation, review and cite previous work. A 1989 editorial about the response was critical to investigators for measuring physiology but not outcome; for nonetheless making recommendations; for studying only patients not at risk; and for implying patients are at risk when this is not certain. A systemic Medline search was made for English language reports published during or after 1990, and their citation lists read for missed reports. All retrieved papers were read for citation of the editorial and for acknowledgement of its criticisms. Citations were tabulated, and cross-referenced between papers, to see whether blocks of citations had been obtained from other investigators' reports. Eighty-one full reports, from 48 groups of investigators, were obtained. The 1989 editorial was cited twice. All studies included physiological measurements, but none reported long-term outcome. There was no comment on the need to know outcome in 39 reports. Pre-existing risk factors were exclusions in 65 studies. In 56 papers, complications of the response were given as the reason for the study; in 41 of these papers only healthy subjects were studied. In total, 249 references about the response were identified from the 81 papers. There was no obvious evidence that citations were obtained from others' papers. Recognised deficiencies in research method were not acknowledged. When submitting work for publication, investigators should provide evidence of how they searched for previous work.

Short papers in geology, hydrology, and topography; Articles 120-179

USGS Publications Warehouse

,

1962-01-01

This collection of 60 short papers on subjects in the fields of geology, hydrology, topography, and related sciences is the third of a series to be released during the year as chapters of Professional Paper 450. The papers in this chapter report on the scientific and economic results of current work by members of the Geologic, Water Resources, and Topographic Divisions of the United States Geologicai Survey. Some of the papers announce new discoveries or present observations on problems of limited scope; other papers draw conclusions from more extensive or continuing investigations that in large part will be discussed in greater detail in reports to be published in the future.Chapter A of this series, to be published later in the year, will present a synopsis of results from a wide range of work done during the present fiscal year.

P-12 Engineering Education Research and Practice

ERIC Educational Resources Information Center

Moore, Tamara; Richards, Larry G.

2012-01-01

This special issue of "Advances in Engineering Education" explores recent developments in P-12 Engineering Education. It includes papers devoted to research and practice, and reports some of the most exciting work in the field today. In our Call of Papers, we solicited two types of papers: Research papers and Practice papers. The former…

Wind Speed Measurement by Paper Anemometer

ERIC Educational Resources Information Center

Zhong, Juhua; Cheng, Zhongqi; Guan, Wenchuan

2011-01-01

A simple wind speed measurement device, a paper anemometer, is fabricated based on the theory of standing waves. In providing the working profile of the paper anemometer, an experimental device is established, which consists of an anemometer sensor, a sound sensor, a microphone, paper strips, a paper cup, and sonic acquisition software. It shows…

Issues Regarding the Assimilation of Cloud and Precipitation Data

NASA Technical Reports Server (NTRS)

Errico, Ronald M.; Bauer, Peter; Mahfouf, Jean-Francois

2008-01-01

This is the authors' response to a set of criticisms regarding a previously published work. It briefly addresses the main criticisms. In particular, it explains why some papers identified as having some fundamental flaws were referenced in the original work without detailed exposition of those flaws. It also explains why parts of the conclusion criticized as being contradictory are, in fact, not. It further highlights the need for more publishing of scientific criticisms. In the December 2007, special issue of the Journal of Atmospheric Sciences devoted to the Workshop on Assimilation of Satellite Cloud and Precipitation Observations, the authors published an article summarizing the many critical issues that render observations of cloud and precipitation difficult to analyze. Essentially, these include the inaccuracies of both current instruments and the relationships between what is actually observed (infrared or microwave energy detected at the altitude of the satellite) to what is desired (e.g., estimates of cloud drop sizes or rain rates) and the chaotic nature of atmospheric behavior and the complex mathematics describing it. The paper also included recommendations for future research and brief descriptions of many previous works concerning the subject. One reader is now attempting to publish a criticism of that paper. Her three complaints are that there was insufficient explanation of the identification of some cited works as being fundamentally flawed, that as a review the paper should have referenced some works additional to those it did, and that two recommendations were contradictory. Each of these complaints is addressed briefly in this response. First we explain why a brief list of works cited in our paper were identified as "flawed" with only a brief explanation. The design and conduct of the experiments reported in those papers violate well-established fundamentals such that, once the errors are recognized, their interpretations are no longer supported. Unfortunately, over the years, no researchers have bothered to publish criticisms of those papers, such that there are now too many to address in any single paper not devoted to that purpose. Yet, those papers are so often cited that we could not simply ignore them. Furthermore, if we had cited them without warning our readers regarding their flaws, we would have perpetrated a great disservice. In our response, however, we do offer further explanation of why some details, neglected in these papers, are critical to proper scientific evaluation. Neither did we offer insufficient references. Although we intentionally did not claim to be a "review' paper, we did cite 100 papers. That number is approximately 5 times the usual amount cited in journal articles. Although we only referenced few papers published after 2005, that was because our manuscript was submitted in January 2006, with its final, editorially-reviewed form in June 2006. We therefore could not reference papers published after this date. The problem here is that our paper was "in press" for 18 months. Finally, we explain that a careful reading of our paper reveals that our recommendations are not contradictory. Essentially, although we recommend 2 very distinct research approaches, these are complimentary and either alone is insufficient to accelerate progress. In conclusion, we recommend that the scientific community expends greater effort in publishing careful scientific criticisms so that others do not face the same dilemma we did. Likely this requires some reward system for doing so.

Key Concepts of Teams in an Organisation. Information Bank Working Paper Number 2541.

ERIC Educational Resources Information Center

Marsh, D. T.

Teams in an organization are more than cooperative working groups. Advantages of group work, as opposed to individual work, include producing a better end result, providing satisfaction for the individual and the organization, and assisting the organization through coordination and work allocation. Disadvantages of group work include producing a…

Exploring team working and shared leadership in multi-disciplinary cancer care.

PubMed

Willcocks, Stephen George

2018-02-05

Purpose The purpose of this paper is to explore the relevance of shared leadership to multi-disciplinary cancer care. It examines the policy background and applies concepts from shared leadership to this context. It includes discussion of the implications and recommendations. Design/methodology/approach This is a conceptual paper examining policy documents and secondary literature on the topic. While it focuses on the UK National Health Services, it is also relevant to other countries given they follow a broadly similar path with regard to multi-disciplinary working. Findings The paper suggests that shared leadership is a possible way forward for multi-disciplinary cancer care, particularly as policy developments are supportive of this. It shows that a shared perspective is likely to be beneficial to the further development of multi-disciplinary working. Research limitations/implications Adopting shared leadership needs to be explored further using appropriate empirical research. Practical implications The paper offers comments on the implications of introducing shared leadership and makes recommendations including being aware of the barriers to its implementation. Originality/value The paper offers an alternative view on leadership in the health-care context.

Computational support of the laminar flow supersonic wind tunnel, CNSFV code development, Maglev, and grid generation

NASA Technical Reports Server (NTRS)

Klopfer, Goetz H.

1995-01-01

This final report covers the work done on corporate agreement NCC2-616 over a period of 5 1/2 years. It is broken into three segments of approximately 1 1/2 to 2 years each. The report is a summary report and is not intended to be comprehensive of all the work done under this corporate agreement. A more complete coverage of the work done is obtained from the papers and reports listed in the 'Papers' section. Additional reporting of significant work was done through 'Technical Highlights' and 'Research and Technical Summaries'. A listing of copies are given in the 'Technical Highlights and R and T' section. The work was also reported in a series of seminars, conference meetings, branch reviews, workshops, and project reviews. A list of these talks is given in the 'Presentation' section. Also during this time three students ranging from high school to graduate level were supervised. A list of the students and the type of work accomplished is given in the 'Mentoring' section. The report concludes with the 'Appendices' sections which include the three papers produced during the last 1 1/2 years of this corporate agreement.

The nearly universal link between the age of past knowledge and tomorrow's breakthroughs in science and technology: The hotspot.

PubMed

Mukherjee, Satyam; Romero, Daniel M; Jones, Ben; Uzzi, Brian

2017-04-01

Scientists and inventors can draw on an ever-expanding literature for the building blocks of tomorrow's ideas, yet little is known about how combinations of past work are related to future discoveries. Our analysis parameterizes the age distribution of a work's references and revealed three links between the age of prior knowledge and hit papers and patents. First, works that cite literature with a low mean age and high age variance are in a citation "hotspot"; these works double their likelihood of being in the top 5% or better of citations. Second, the hotspot is nearly universal in all branches of science and technology and is increasingly predictive of a work's future citation impact. Third, a scientist or inventor is significantly more likely to write a paper in the hotspot when they are coauthoring than whey they are working alone. Our findings are based on all 28,426,345 scientific papers in the Web of Science, 1945-2013, and all 5,382,833 U.S. patents, 1950-2010, and reveal new antecedents of high-impact science and the link between prior literature and tomorrow's breakthrough ideas.

Interprofessional learning at work: what spatial theory can tell us about workplace learning in an acute care ward.

PubMed

Gregory, Linda Rosemary; Hopwood, Nick; Boud, David

2014-05-01

It is widely recognized that every workplace potentially provides a rich source of learning. Studies focusing on health care contexts have shown that social interaction within and between professions is crucial in enabling professionals to learn through work, address problems and cope with challenges of clinical practice. While hospital environments are beginning to be understood in spatial terms, the links between space and interprofessional learning at work have not been explored. This paper draws on Lefebvre's tri-partite theoretical framework of perceived, conceived and lived space to enrich understandings of interprofessional learning on an acute care ward in an Australian teaching hospital. Qualitative analysis was undertaken using data from observations of Registered Nurses at work and semi-structured interviews linked to observed events. The paper focuses on a ward round, the medical workroom and the Registrar's room, comparing and contrasting the intended (conceived), practiced (perceived) and pedagogically experienced (lived) spatial dimensions. The paper concludes that spatial theory has much to offer understandings of interprofessional learning in work, and the features of work environments and daily practices that produce spaces that enable or constrain learning.

"Re-Making" Jobs: Enacting and Learning Work Practices

ERIC Educational Resources Information Center

Price, Oriana Milani; Scheeres, Hermine; Boud, David

2009-01-01

This paper takes up understandings of organisations where practices constitute and frame past and present work, as well as future work practice possibilities. Within this view, work practices, and thus organisations, are both perpetuated and varied through employees' enactments of work. Using a practice lens, we are particularly interested in the…

Operating the production calculus: ordering a production system in the print industry.

PubMed

Button, Graham; Sharrock, Wes

2002-06-01

The topic of shop-floor work has been extensively examined within sociology. However, the organizational structures within which this work takes place have, in the most part, been taken as unexamined givens. Yet, their operation is also the shop-floor work of some people. This paper examines the way in which the stable organizational structures within which shop-floor work takes place are achieved. It is based upon a fieldwork investigation of a large commercial printer and focuses upon the collaborative work of those who are involved in scheduling the production of a job and their use of 'the production calculus' in planning the work of the site. The print industry is undergoing considerable technological change and scheduling technologies have been developed to automate this work. However, there has been little take up of these technologies and the paper also considers how the characteristics of operating the production calculus in practice may account for this.

Neophilia Ranking of Scientific Journals

PubMed Central

Packalen, Mikko; Bhattacharya, Jay

2017-01-01

The ranking of scientific journals is important because of the signal it sends to scientists about what is considered most vital for scientific progress. Existing ranking systems focus on measuring the influence of a scientific paper (citations)—these rankings do not reward journals for publishing innovative work that builds on new ideas. We propose an alternative ranking based on the proclivity of journals to publish papers that build on new ideas, and we implement this ranking via a text-based analysis of all published biomedical papers dating back to 1946. In addition, we compare our neophilia ranking to citation-based (impact factor) rankings; this comparison shows that the two ranking approaches are distinct. Prior theoretical work suggests an active role for our neophilia index in science policy. Absent an explicit incentive to pursue novel science, scientists underinvest in innovative work because of a coordination problem: for work on a new idea to flourish, many scientists must decide to adopt it in their work. Rankings that are based purely on influence thus do not provide sufficient incentives for publishing innovative work. By contrast, adoption of the neophilia index as part of journal-ranking procedures by funding agencies and university administrators would provide an explicit incentive for journals to publish innovative work and thus help solve the coordination problem by increasing scientists' incentives to pursue innovative work. PMID:28713181

[Robotics].

PubMed

Bier, J

2000-05-01

Content of this paper is the current state of the art of robots in surgery and the ongoing work on the field of surgical robotics at the Clinic for Maxillofacial Surgery at the Charité. Robots in surgery allows the surgeon to transform the accuracy of the imaging systems directly during the intervention and to plan an intervention beforehand. In this paper firstly the state of the art is described. Subsequently the scientific work at the clinic is described in detail. The paper closes with a outlook for future applications of robotics systems in maxillofacial surgery.

The design of PC/MISI, a PC-based common user interface to remote information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Hall, Philip P.

1985-01-01

This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-15. The paper discusses the following: problem definition; the PC solution; the goals of system design; the design description; future considerations, the research environment; conclusions.

The Potential of Captioned Television for Adult Learners. Working Papers of Planning and Development Research. Working Paper 88-3.

ERIC Educational Resources Information Center

Mehler, Audrey

With the assistance of the Canadian Captioning Development Agency, TVOntario has undertaken to determine the efficacy of applying closed-captioned television to the needs of adult learners who are not hearing impaired. In this research study, actual and potential applications of closed-captioned television for hearing audiences in Canada, the…