Finite element model updating and damage detection for bridges using vibration measurement.

DOT National Transportation Integrated Search

2013-12-01

In this report, the results of a study on developing a damage detection methodology based on Statistical Pattern Recognition are : presented. This methodology uses a new damage sensitive feature developed in this study that relies entirely on modal :...

Finite element method for viscoelastic medium with damage and the application to structural analysis of solid rocket motor grain

NASA Astrophysics Data System (ADS)

Deng, Bin; Shen, ZhiBin; Duan, JingBo; Tang, GuoJin

2014-05-01

This paper studies the damage-viscoelastic behavior of composite solid propellants of solid rocket motors (SRM). Based on viscoelastic theories and strain equivalent hypothesis in damage mechanics, a three-dimensional (3-D) nonlinear viscoelastic constitutive model incorporating with damage is developed. The resulting viscoelastic constitutive equations are numerically discretized by integration algorithm, and a stress-updating method is presented by solving nonlinear equations according to the Newton-Raphson method. A material subroutine of stress-updating is made up and embedded into commercial code of Abaqus. The material subroutine is validated through typical examples. Our results indicate that the finite element results are in good agreement with the analytical ones and have high accuracy, and the suggested method and designed subroutine are efficient and can be further applied to damage-coupling structural analysis of practical SRM grain.

Statistical and perceptual updating: correlated impairments in right brain injury.

PubMed

Stöttinger, Elisabeth; Filipowicz, Alex; Marandi, Elahe; Quehl, Nadine; Danckert, James; Anderson, Britt

2014-06-01

It has been hypothesized that many of the cognitive impairments commonly seen after right brain damage (RBD) can be characterized as a failure to build or update mental models. We (Danckert et al. in Neglect as a disorder of representational updating. NOVA Open Access, New York, 2012a; Cereb Cortex 22:2745-2760, 2012b) were the first to directly assess the association between RBD and updating and found that RBD patients were unable to exploit a strongly biased play strategy in their opponent in the children's game rock, paper, scissors. Given that this game required many other cognitive capacities (i.e., working memory, sustained attention, reward processing), RBD patients could have failed this task for various reasons other than a failure to update. To assess the generality of updating deficits after RBD, we had RBD, left brain-damaged (LBD) patients and healthy controls (HCs) describe line drawings that evolved gradually from one figure (e.g., rabbit) to another (e.g., duck) in addition to the RPS updating task. RBD patients took significantly longer to alter their perceptual report from the initial object to the final object than did LBD patients and HCs. Although both patient groups performed poorly on the RPS task, only the RBD patients showed a significant correlation between the two, very different, updating tasks. We suggest these data indicate a general deficiency in the ability to update mental representations following RBD.

Detestable or marvelous? Neuroanatomical correlates of character judgments.

PubMed

Croft, Katie E; Duff, Melissa C; Kovach, Christopher K; Anderson, Steven W; Adolphs, Ralph; Tranel, Daniel

2010-05-01

As we learn new information about the social and moral behaviors of other people, we form and update character judgments of them, and this can profoundly influence how we regard and act towards others. In the study reported here, we capitalized on two interesting neurological patient populations where this process of complex "moral updating" may go awry: patients with bilateral damage to ventromedial prefrontal cortex (vmPFC) and patients with bilateral damage to hippocampus (HC). We predicted that vmPFC patients, who have impaired emotion processing, would exhibit reduced moral updating, and we also investigated how moral updating might be affected by severe declarative memory impairment in HC patients. The vmPFC, HC, and brain-damaged comparison (BDC) participants made moral judgments about unfamiliar persons before and after exposure to social scenarios depicting the persons engaged in morally good, bad, or neutral behaviors. In line with our prediction, the vmPFC group showed the least amount of change in moral judgments, and interestingly, the HC group showed the most amount of change. These results suggest that the vmPFC and hippocampus play critical but complementary roles in updating moral character judgments about others: the vmPFC may attribute emotional salience to moral information, whereas the hippocampus may provide necessary contextual information from which to make appropriate character judgments. 2010 Elsevier Ltd. All rights reserved.

Online damage detection using recursive principal component analysis and recursive condition indicators

NASA Astrophysics Data System (ADS)

Krishnan, M.; Bhowmik, B.; Tiwari, A. K.; Hazra, B.

2017-08-01

In this paper, a novel baseline free approach for continuous online damage detection of multi degree of freedom vibrating structures using recursive principal component analysis (RPCA) in conjunction with online damage indicators is proposed. In this method, the acceleration data is used to obtain recursive proper orthogonal modes in online using the rank-one perturbation method, and subsequently utilized to detect the change in the dynamic behavior of the vibrating system from its pristine state to contiguous linear/nonlinear-states that indicate damage. The RPCA algorithm iterates the eigenvector and eigenvalue estimates for sample covariance matrices and new data point at each successive time instants, using the rank-one perturbation method. An online condition indicator (CI) based on the L2 norm of the error between actual response and the response projected using recursive eigenvector matrix updates over successive iterations is proposed. This eliminates the need for offline post processing and facilitates online damage detection especially when applied to streaming data. The proposed CI, named recursive residual error, is also adopted for simultaneous spatio-temporal damage detection. Numerical simulations performed on five-degree of freedom nonlinear system under white noise and El Centro excitations, with different levels of nonlinearity simulating the damage scenarios, demonstrate the robustness of the proposed algorithm. Successful results obtained from practical case studies involving experiments performed on a cantilever beam subjected to earthquake excitation, for full sensors and underdetermined cases; and data from recorded responses of the UCLA Factor building (full data and its subset) demonstrate the efficacy of the proposed methodology as an ideal candidate for real-time, reference free structural health monitoring.

Remote sensing as tool for development of landslide databases: The case of the Messina Province (Italy) geodatabase

NASA Astrophysics Data System (ADS)

Ciampalini, Andrea; Raspini, Federico; Bianchini, Silvia; Frodella, William; Bardi, Federica; Lagomarsino, Daniela; Di Traglia, Federico; Moretti, Sandro; Proietti, Chiara; Pagliara, Paola; Onori, Roberta; Corazza, Angelo; Duro, Andrea; Basile, Giuseppe; Casagli, Nicola

2015-11-01

Landslide geodatabases, including inventories and thematic data, today are fundamental tools for national and/or local authorities in susceptibility, hazard and risk management. A well organized landslide geo-database contains different kinds of data such as past information (landslide inventory maps), ancillary data and updated remote sensing (space-borne and ground based) data, which can be integrated in order to produce landslide susceptibility maps, updated landslide inventory maps and hazard and risk assessment maps. Italy is strongly affected by landslide phenomena which cause victims and significant economic damage to buildings and infrastructure, loss of productive soils and pasture lands. In particular, the Messina Province (southern Italy) represents an area where landslides are recurrent and characterized by high magnitude, due to several predisposing factors (e.g. morphology, land use, lithologies) and different triggering mechanisms (meteorological conditions, seismicity, active tectonics and volcanic activity). For this area, a geodatabase was created by using different monitoring techniques, including remote sensing (e.g. SAR satellite ERS1/2, ENVISAT, RADARSAT-1, TerraSAR-X, COSMO-SkyMed) data, and in situ measurements (e.g. GBInSAR, damage assessment). In this paper a complete landslide geodatabase of the Messina Province, designed following the requirements of the local and national Civil Protection authorities, is presented. This geo-database was used to produce maps (e.g. susceptibility, ground deformation velocities, damage assessment, risk zonation) which today are constantly used by the Civil Protection authorities to manage the landslide hazard of the Messina Province.

Damage identification via asymmetric active magnetic bearing acceleration feedback control

NASA Astrophysics Data System (ADS)

Zhao, Jie; DeSmidt, Hans; Yao, Wei

2015-04-01

A Floquet-based damage detection methodology for cracked rotor systems is developed and demonstrated on a shaft-disk system. This approach utilizes measured changes in the system natural frequencies to estimate the severity and location of shaft structural cracks during operation. The damage detection algorithms are developed with the initial guess solved by least square method and iterative damage parameter vector by updating the eigenvector updating. Active Magnetic Bearing is introduced to break the symmetric structure of rotor system and the tuning range of proper stiffness/virtual mass gains is studied. The system model is built based on energy method and the equations of motion are derived by applying assumed modes method and Lagrange Principle. In addition, the crack model is based on the Strain Energy Release Rate (SERR) concept in fracture mechanics. Finally, the method is synthesized via harmonic balance and numerical examples for a shaft/disk system demonstrate the effectiveness in detecting both location and severity of the structural damage.

Stochastic filtering for damage identification through nonlinear structural finite element model updating

NASA Astrophysics Data System (ADS)

Astroza, Rodrigo; Ebrahimian, Hamed; Conte, Joel P.

2015-03-01

This paper describes a novel framework that combines advanced mechanics-based nonlinear (hysteretic) finite element (FE) models and stochastic filtering techniques to estimate unknown time-invariant parameters of nonlinear inelastic material models used in the FE model. Using input-output data recorded during earthquake events, the proposed framework updates the nonlinear FE model of the structure. The updated FE model can be directly used for damage identification and further used for damage prognosis. To update the unknown time-invariant parameters of the FE model, two alternative stochastic filtering methods are used: the extended Kalman filter (EKF) and the unscented Kalman filter (UKF). A three-dimensional, 5-story, 2-by-1 bay reinforced concrete (RC) frame is used to verify the proposed framework. The RC frame is modeled using fiber-section displacement-based beam-column elements with distributed plasticity and is subjected to the ground motion recorded at the Sylmar station during the 1994 Northridge earthquake. The results indicate that the proposed framework accurately estimate the unknown material parameters of the nonlinear FE model. The UKF outperforms the EKF when the relative root-mean-square error of the recorded responses are compared. In addition, the results suggest that the convergence of the estimate of modeling parameters is smoother and faster when the UKF is utilized.

Predicting remaining life by fusing the physics of failure modeling with diagnostics

NASA Astrophysics Data System (ADS)

Kacprzynski, G. J.; Sarlashkar, A.; Roemer, M. J.; Hess, A.; Hardman, B.

2004-03-01

Technology that enables failure prediction of critical machine components (prognostics) has the potential to significantly reduce maintenance costs and increase availability and safety. This article summarizes a research effort funded through the U.S. Defense Advanced Research Projects Agency and Naval Air System Command aimed at enhancing prognostic accuracy through more advanced physics-of-failure modeling and intelligent utilization of relevant diagnostic information. H-60 helicopter gear is used as a case study to introduce both stochastic sub-zone crack initiation and three-dimensional fracture mechanics lifing models along with adaptive model updating techniques for tuning key failure mode variables at a local material/damage site based on fused vibration features. The overall prognostic scheme is aimed at minimizing inherent modeling and operational uncertainties via sensed system measurements that evolve as damage progresses.

Damage identification in beams using speckle shearography and an optimal spatial sampling

NASA Astrophysics Data System (ADS)

Mininni, M.; Gabriele, S.; Lopes, H.; Araújo dos Santos, J. V.

2016-10-01

Over the years, the derivatives of modal displacement and rotation fields have been used to localize damage in beams. Usually, the derivatives are computed by applying finite differences. The finite differences propagate and amplify the errors that exist in real measurements, and thus, it is necessary to minimize this problem in order to get reliable damage localizations. A way to decrease the propagation and amplification of the errors is to select an optimal spatial sampling. This paper presents a technique where an optimal spatial sampling of modal rotation fields is computed and used to obtain the modal curvatures. Experimental measurements of modal rotation fields of a beam with single and multiple damages are obtained with shearography, which is an optical technique allowing the measurement of full-fields. These measurements are used to test the validity of the optimal sampling technique for the improvement of damage localization in real structures. An investigation on the ability of a model updating technique to quantify the damage is also reported. The model updating technique is defined by the variations of measured natural frequencies and measured modal rotations and aims at calibrating the values of the second moment of area in the damaged areas, which were previously localized.

Detection of damage in welded structure using experimental modal data

NASA Astrophysics Data System (ADS)

Abu Husain, N.; Ouyang, H.

2011-07-01

A typical automotive structure could contain thousands of spot weld joints that contribute significantly to the vehicle's structural stiffness and dynamic characteristics. However, some of these joints may be imperfect or even absent during the manufacturing process and they are also highly susceptible to damage due to operational and environmental conditions during the vehicle lifetime. Therefore, early detection and estimation of damage are important so necessary actions can be taken to avoid further problems. Changes in physical parameters due to existence of damage in a structure often leads to alteration of vibration modes; thus demonstrating the dependency between the vibration characteristics and the physical properties of structures. A sensitivity-based model updating method, performed using a combination of MATLAB and NASTRAN, has been selected for the purpose of this work. The updating procedure is regarded as parameter identification which aims to bring the numerical prediction to be as closely as possible to the measured natural frequencies and mode shapes data of the damaged structure in order to identify the damage parameters (characterised by the reductions in the Young's modulus of the weld patches to indicate the loss of material/stiffness at the damage region).

A Fatigue Crack Size Evaluation Method Based on Lamb Wave Simulation and Limited Experimental Data

PubMed Central

He, Jingjing; Ran, Yunmeng; Liu, Bin; Yang, Jinsong; Guan, Xuefei

2017-01-01

This paper presents a systematic and general method for Lamb wave-based crack size quantification using finite element simulations and Bayesian updating. The method consists of construction of a baseline quantification model using finite element simulation data and Bayesian updating with limited Lamb wave data from target structure. The baseline model correlates two proposed damage sensitive features, namely the normalized amplitude and phase change, with the crack length through a response surface model. The two damage sensitive features are extracted from the first received S0 mode wave package. The model parameters of the baseline model are estimated using finite element simulation data. To account for uncertainties from numerical modeling, geometry, material and manufacturing between the baseline model and the target model, Bayesian method is employed to update the baseline model with a few measurements acquired from the actual target structure. A rigorous validation is made using in-situ fatigue testing and Lamb wave data from coupon specimens and realistic lap-joint components. The effectiveness and accuracy of the proposed method is demonstrated under different loading and damage conditions. PMID:28902148

Continuous flow measurements using ultrasonic velocity meters - an update

USGS Publications Warehouse

Oltmann, Rick

1995-01-01

An article in the summer 1993 Newsletter described USGS work to continously monitor tidal flows in the delta using ultrasonic velocity meters.  This article updates progress since 1993, including new installations, results of data analysis, damage during this year's high flows, and the status of each site.

Damage Detection in Flexible Plates through Reduced-Order Modeling and Hybrid Particle-Kalman Filtering

PubMed Central

Capellari, Giovanni; Eftekhar Azam, Saeed; Mariani, Stefano

2015-01-01

Health monitoring of lightweight structures, like thin flexible plates, is of interest in several engineering fields. In this paper, a recursive Bayesian procedure is proposed to monitor the health of such structures through data collected by a network of optimally placed inertial sensors. As a main drawback of standard monitoring procedures is linked to the computational costs, two remedies are jointly considered: first, an order-reduction of the numerical model used to track the structural dynamics, enforced with proper orthogonal decomposition; and, second, an improved particle filter, which features an extended Kalman updating of each evolving particle before the resampling stage. The former remedy can reduce the number of effective degrees-of-freedom of the structural model to a few only (depending on the excitation), whereas the latter one allows to track the evolution of damage and to locate it thanks to an intricate formulation. To assess the effectiveness of the proposed procedure, the case of a plate subject to bending is investigated; it is shown that, when the procedure is appropriately fed by measurements, damage is efficiently and accurately estimated. PMID:26703615

Development of a procedure for updating liquidated damage rates used in ALDOT construction contracts.

DOT National Transportation Integrated Search

2008-10-01

This research effort sought to develop statistically justifiable means for developing a : schedule of liquidated damage (LD) rates to be adopted by the Alabama Department of : Transportation (ALDOT). The procedure outlined is to be used to review and...

Firefighting and Emergency Response Study of Advanced Composites Aircraft; Objective 1: Composite Material Damage in Minor Aircraft Fires

DTIC Science & Technology

2013-05-18

26 4.3. 1-D Heat Transfer Model with Pyrolysis and Thermal Damage...Improvements and Added Features ........................................................................31 4.3.4. Pyrolysis Model Calibration... Pyrolysis Model ................................................32 Figure 25. Updated Heat Transfer Algorithm Flow Chart

GRAPPA 2015 Research and Education Project Reports.

PubMed

Mease, Philip J; Helliwell, Philip S; Boehncke, Wolf-Henning; Coates, Laura C; FitzGerald, Oliver; Gladman, Dafna D; Deodhar, Atul A; Callis Duffin, Kristina

2016-05-01

At the 2015 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), attendees were presented with brief updates on several ongoing initiatives, including educational projects. Updates were presented on the treatment recommendations project, the development of simple criteria to identify inflammatory musculoskeletal disease, new patient/physician Delphi exercises, and BIODAM (identifying biomarkers that predict progressive structural joint damage). The publication committee also gave a report. Herein we summarize those project updates.

Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review.

PubMed

Teh, Seoh Wei; Mok, Pooi Ling; Abd Rashid, Munirah; Bastion, Mae-Lynn Catherine; Ibrahim, Normala; Higuchi, Akon; Murugan, Kadarkarai; Mariappan, Rajan; Subbiah, Suresh Kumar

2018-02-13

Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections.

Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review

PubMed Central

Teh, Seoh Wei; Mok, Pooi Ling; Abd Rashid, Munirah; Bastion, Mae-Lynn Catherine; Ibrahim, Normala; Higuchi, Akon; Murugan, Kadarkarai; Mariappan, Rajan

2018-01-01

Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections. PMID:29438279

A response surface methodology based damage identification technique

NASA Astrophysics Data System (ADS)

Fang, S. E.; Perera, R.

2009-06-01

Response surface methodology (RSM) is a combination of statistical and mathematical techniques to represent the relationship between the inputs and outputs of a physical system by explicit functions. This methodology has been widely employed in many applications such as design optimization, response prediction and model validation. But so far the literature related to its application in structural damage identification (SDI) is scarce. Therefore this study attempts to present a systematic SDI procedure comprising four sequential steps of feature selection, parameter screening, primary response surface (RS) modeling and updating, and reference-state RS modeling with SDI realization using the factorial design (FD) and the central composite design (CCD). The last two steps imply the implementation of inverse problems by model updating in which the RS models substitute the FE models. The proposed method was verified against a numerical beam, a tested reinforced concrete (RC) frame and an experimental full-scale bridge with the modal frequency being the output responses. It was found that the proposed RSM-based method performs well in predicting the damage of both numerical and experimental structures having single and multiple damage scenarios. The screening capacity of the FD can provide quantitative estimation of the significance levels of updating parameters. Meanwhile, the second-order polynomial model established by the CCD provides adequate accuracy in expressing the dynamic behavior of a physical system.

On the Role of Urban and Vegetative Land Cover in the Identification of Tornado Damage Using Dual-Resolution Multispectral Satellite Imagery

NASA Astrophysics Data System (ADS)

Kingfield, D.; de Beurs, K.

2014-12-01

It has been demonstrated through various case studies that multispectral satellite imagery can be utilized in the identification of damage caused by a tornado through the change detection process. This process involves the difference in returned surface reflectance between two images and is often summarized through a variety of ratio-based vegetation indices (VIs). Land cover type plays a large contributing role in the change detection process as the reflectance properties of vegetation can vary based on several factors (e.g. species, greenness, density). Consequently, this provides the possibility for a variable magnitude of loss, making certain land cover regimes less reliable in the damage identification process. Furthermore, the tradeoff between sensor resolution and orbital return period may also play a role in the ability to detect catastrophic loss. Moderate resolution imagery (e.g. Moderate Resolution Imaging Spectroradiometer (MODIS)) provides relatively coarse surface detail with a higher update rate which could hinder the identification of small regions that underwent a dynamic change. Alternatively, imagery with higher spatial resolution (e.g. Landsat) have a longer temporal return period between successive images which could result in natural recovery underestimating the absolute magnitude of damage incurred. This study evaluates the role of land cover type and sensor resolution on four high-end (EF3+) tornado events occurring in four different land cover groups (agriculture, forest, grassland, urban) in the spring season. The closest successive clear images from both Landsat 5 and MODIS are quality controlled for each case. Transacts of surface reflectance across a homogenous land cover type both inside and outside the damage swath are extracted. These metrics are synthesized through the calculation of six different VIs to rank the calculated change metrics by land cover type, sensor resolution and VI.

Multi-Hazard Assessment of Scour Damaged Bridges with UAS-Based Measurements

NASA Astrophysics Data System (ADS)

Özcan, O.; Ozcan, O.

2017-12-01

Flood and stream induced scour occurring in bridge piers constructed on rivers is one of the mostly observed failure reasons in bridges. Scour induced failure risk in bridges and determination of the alterations in bridge safety under seismic effects has the ultimate importance. Thus, for the determination of bridge safety under the scour effects, the scour amount under bridge piers should be designated realistically and should be tracked and updated continuously. Hereby, the scour induced failures in bridge foundation systems will be prevented and bridge substructure design will be conducted safely. In this study, in order to measure the amount of scour in bridge load bearing system (pile foundations and pile abutments) and to attain very high definition 3 dimensional models of river flood plain for the flood analysis, unmanned aircraft system (UAS) based measurement methods were implemented. UAS based measurement systems provide new and practical approach and bring high precision and reliable solutions considering recent measurement systems. For this purpose, the reinforced concrete (RC) bridge that is located on Antalya Boğaçayı River, Turkey and that failed in 2003 due to flood-induced scour was selected as the case study. The amount of scour occurred in bridge piers and piles was determined realistically and the behavior of bridge piers under scour effects was investigated. Future flood effects and the resultant amount of scour was determined with HEC-RAS software by using digital surface models that were obtained at regular intervals using UAS for the riverbed. In the light of the attained scour measurements and expected scour after a probable flood event, the behavior of scour damaged RC bridge was investigated by pushover and time history analyses under lateral and vertical seismic loadings. In the analyses, the load and displacement capacity of bridge was observed to diminish significantly under expected scour. Thus, the deterioration in multi hazard performance of the bridge was monitored significantly in the light of updated bridge load bearing system capacity. Regarding the case study, UAS based and continuously updated bridge multi hazard risk detection system was established that can be used for bridges located on riverbed.

Updating impairments and the failure to explore new hypotheses following right brain damage.

PubMed

Stöttinger, Elisabeth; Guay, Carolyn Louise; Danckert, James; Anderson, Britt

2018-06-01

We have shown recently that damage to the right hemisphere impairs the ability to update mental models when evidence suggests an old model is no longer appropriate. We argue that this deficit is generic in the sense that it crosses multiple cognitive and perceptual domains. Here, we examined the nature of this updating impairment to determine more precisely the underlying mechanisms. We had right (RBD, N = 12) and left brain damaged (LBD, N = 10) patients perform versions of our picture-morphing task in which pictures gradually morph from one object (e.g., shark) to another (e.g., plane). Performance was contrasted against two groups of healthy older controls, one matched on age (HCO-age-matched, N = 9) and another matched on general level of cognitive ability (HCO-cognitively-matched, N = 9). We replicated our earlier findings showing that RBD patients took longer than LBD patients and HCOs to report seeing the second object in a sequence of morphing images. The groups did not differ when exposed to a morphing sequence a second time, or when responding to ambiguous images outside the morphing context. This indicates that RBD patients have little difficulty alternating between known representations or labeling ambiguous images. Instead, the difficulty lies in generating alternate hypotheses for ambiguous information. Lesion overlay analyses, although speculative given the sample size, are consistent with our fMRI work in healthy individuals in implicating the anterior insular cortex as critical for updating mental models.

Quantitative Measures for Evaluation of Ultrasound Therapies of the Prostate

NASA Astrophysics Data System (ADS)

Kobelevskiy, Ilya; Burtnyk, Mathieu; Bronskill, Michael; Chopra, Rajiv

2010-03-01

Development of non-invasive techniques for prostate cancer treatment requires implementation of quantitative measures for evaluation of the treatment results. In this paper. we introduce measures that estimate spatial targeting accuracy and potential thermal damage to the structures surrounding the prostate. The measures were developed for the technique of treating prostate cancer with a transurethral ultrasound heating applicators guided by active MR temperature feedback. Variations of ultrasound element length and related MR imaging parameters such as MR slice thickness and update time were investigated by performing numerical simulations of the treatment on a database of ten patient prostate geometries segmented from clinical MR images. Susceptibility of each parameter configuration to uncertainty in MR temperature measurements was studied by adding noise to the temperature measurements. Gaussian noise with zero mean and standard deviation of 0, 1, 3 and 5° C was used to model different levels of uncertainty in MR temperature measurements. Results of simulations for each parameter configuration were averaged over the database of the ten prostate patient geometries studied. Results have shown that for update time of 5 seconds both 3- and 5-mm elements achieve appropriate performance for temperature uncertainty up to 3° C, while temperature uncertainty of 5° C leads to noticeable reduction in spatial accuracy and increased risk of damaging rectal wall. Ten-mm elements lacked spatial accuracy and had higher risk of damaging rectal wall compared to 3- and 5-mm elements, but were less sensitive to the level of temperature uncertainty. The effect of changing update time was studied for 5-mm elements. Simulations showed that update time had minor effects on all aspects of treatment for temperature uncertainty of 0° C and 1° C, while temperature uncertainties of 3° C and 5° C led to reduced spatial accuracy, increased potential damage to the rectal wall, and longer treatment times for update time above 5 seconds. Overall evaluation of results suggested that 5-mm elements showed best performance under physically reachable MR imaging parameters.

A recursive Bayesian approach for fatigue damage prognosis: An experimental validation at the reliability component level

NASA Astrophysics Data System (ADS)

Gobbato, Maurizio; Kosmatka, John B.; Conte, Joel P.

2014-04-01

Fatigue-induced damage is one of the most uncertain and highly unpredictable failure mechanisms for a large variety of mechanical and structural systems subjected to cyclic and random loads during their service life. A health monitoring system capable of (i) monitoring the critical components of these systems through non-destructive evaluation (NDE) techniques, (ii) assessing their structural integrity, (iii) recursively predicting their remaining fatigue life (RFL), and (iv) providing a cost-efficient reliability-based inspection and maintenance plan (RBIM) is therefore ultimately needed. In contribution to these objectives, the first part of the paper provides an overview and extension of a comprehensive reliability-based fatigue damage prognosis methodology — previously developed by the authors — for recursively predicting and updating the RFL of critical structural components and/or sub-components in aerospace structures. In the second part of the paper, a set of experimental fatigue test data, available in the literature, is used to provide a numerical verification and an experimental validation of the proposed framework at the reliability component level (i.e., single damage mechanism evolving at a single damage location). The results obtained from this study demonstrate (i) the importance and the benefits of a nearly continuous NDE monitoring system, (ii) the efficiency of the recursive Bayesian updating scheme, and (iii) the robustness of the proposed framework in recursively updating and improving the RFL estimations. This study also demonstrates that the proposed methodology can lead to either an extent of the RFL (with a consequent economical gain without compromising the minimum safety requirements) or an increase of safety by detecting a premature fault and therefore avoiding a very costly catastrophic failure.

Investigations & Casualty Analysis « Coast Guard Maritime Commons

Science.gov Websites

marine casualty reporting property damage thresholds now in effect This post provides links to updated : This post was updated April 10, 2018 to reflect that Inmarsat will begin the migration 1400 UTC May 9 website provided in our blog post. Inmarsat announced that it will migrate Inmarsat-C, Mini C, and Fleet77

The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group.

PubMed

Østergaard, Mikkel; Peterfy, Charles G; Bird, Paul; Gandjbakhch, Frédérique; Glinatsi, Daniel; Eshed, Iris; Haavardsholm, Espen A; Lillegraven, Siri; Bøyesen, Pernille; Ejbjerg, Bo; Foltz, Violaine; Emery, Paul; Genant, Harry K; Conaghan, Philip G

2017-11-01

The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Updated 2016 RAMRIS recommendations and a research agenda were developed.

Uncertainty quantification and propagation in dynamic models using ambient vibration measurements, application to a 10-story building

NASA Astrophysics Data System (ADS)

Behmanesh, Iman; Yousefianmoghadam, Seyedsina; Nozari, Amin; Moaveni, Babak; Stavridis, Andreas

2018-07-01

This paper investigates the application of Hierarchical Bayesian model updating for uncertainty quantification and response prediction of civil structures. In this updating framework, structural parameters of an initial finite element (FE) model (e.g., stiffness or mass) are calibrated by minimizing error functions between the identified modal parameters and the corresponding parameters of the model. These error functions are assumed to have Gaussian probability distributions with unknown parameters to be determined. The estimated parameters of error functions represent the uncertainty of the calibrated model in predicting building's response (modal parameters here). The focus of this paper is to answer whether the quantified model uncertainties using dynamic measurement at building's reference/calibration state can be used to improve the model prediction accuracies at a different structural state, e.g., damaged structure. Also, the effects of prediction error bias on the uncertainty of the predicted values is studied. The test structure considered here is a ten-story concrete building located in Utica, NY. The modal parameters of the building at its reference state are identified from ambient vibration data and used to calibrate parameters of the initial FE model as well as the error functions. Before demolishing the building, six of its exterior walls were removed and ambient vibration measurements were also collected from the structure after the wall removal. These data are not used to calibrate the model; they are only used to assess the predicted results. The model updating framework proposed in this paper is applied to estimate the modal parameters of the building at its reference state as well as two damaged states: moderate damage (removal of four walls) and severe damage (removal of six walls). Good agreement is observed between the model-predicted modal parameters and those identified from vibration tests. Moreover, it is shown that including prediction error bias in the updating process instead of commonly-used zero-mean error function can significantly reduce the prediction uncertainties.

Computational simulation of the creep-rupture process in filamentary composite materials

NASA Technical Reports Server (NTRS)

Slattery, Kerry T.; Hackett, Robert M.

1991-01-01

A computational simulation of the internal damage accumulation which causes the creep-rupture phenomenon in filamentary composite materials is developed. The creep-rupture process involves complex interactions between several damage mechanisms. A statistically-based computational simulation using a time-differencing approach is employed to model these progressive interactions. The finite element method is used to calculate the internal stresses. The fibers are modeled as a series of bar elements which are connected transversely by matrix elements. Flaws are distributed randomly throughout the elements in the model. Load is applied, and the properties of the individual elements are updated at the end of each time step as a function of the stress history. The simulation is continued until failure occurs. Several cases, with different initial flaw dispersions, are run to establish a statistical distribution of the time-to-failure. The calculations are performed on a supercomputer. The simulation results compare favorably with the results of creep-rupture experiments conducted at the Lawrence Livermore National Laboratory.

Demagnetization monitoring and life extending control for permanent magnet-driven traction systems

NASA Astrophysics Data System (ADS)

Niu, Gang; Liu, Senyi

2018-03-01

This paper presents a novel scheme of demagnetization monitoring and life extending control for traction systems driven by permanent magnet synchronous motors (PMSMs). Firstly, the offline training is carried to evaluate fatigue damage of insulated gate bipolar transistors (IGBTs) under different flux loss based on first-principle modeling. Then an optimal control law can be extracted by turning down the power distribution factor of the demagnetizing PMSM until all damages of IGBTs turn to balance. Next, the similarity-based empirical modeling is employed to online estimate remaining flux of PMSMs, which is used to update the power distribution factor by referring the optimal control law for the health-oriented autonomous control. The proposed strategy can be demonstrated by a case study of traction drive system coupled with dual-PMSMs. Compared with traditional control strategy, the results show that the novel scheme can not only guarantee traction performance but also extend remaining useful life (RUL) of the system after suffering demagnetization fault.

An Update on the Conceptual-Production Systems Model of Apraxia: Evidence from Stroke

ERIC Educational Resources Information Center

Stamenova, Vessela; Black, Sandra E.; Roy, Eric A.

2012-01-01

Limb apraxia is a neurological disorder characterized by an inability to pantomime and/or imitate gestures. It is more commonly observed after left hemisphere damage (LHD), but has also been reported after right hemisphere damage (RHD). The Conceptual-Production Systems model (Roy, 1996) suggests that three systems are involved in the control of…

Structural Finite Element Model Updating Using Vibration Tests and Modal Analysis for NPL footbridge - SHM demonstrator

NASA Astrophysics Data System (ADS)

Barton, E.; Middleton, C.; Koo, K.; Crocker, L.; Brownjohn, J.

2011-07-01

This paper presents the results from collaboration between the National Physical Laboratory (NPL) and the University of Sheffield on an ongoing research project at NPL. A 50 year old reinforced concrete footbridge has been converted to a full scale structural health monitoring (SHM) demonstrator. The structure is monitored using a variety of techniques; however, interrelating results and converting data to knowledge are not possible without a reliable numerical model. During the first stage of the project, the work concentrated on static loading and an FE model of the undamaged bridge was created, and updated, under specified static loading and temperature conditions. This model was found to accurately represent the response under static loading and it was used to identify locations for sensor installation. The next stage involves the evaluation of repair/strengthening patches under both static and dynamic loading. Therefore, before deliberately introducing significant damage, the first set of dynamic tests was conducted and modal properties were estimated. The measured modal properties did not match the modal analysis from the statically updated FE model; it was clear that the existing model required updating. This paper introduces the results of the dynamic testing and model updating. It is shown that the structure exhibits large non-linear, amplitude dependant characteristics. This creates a difficult updating process, but we attempt to produce the best linear representation of the structure. A sensitivity analysis is performed to determine the most sensitive locations for planned damage/repair scenarios and is used to decide whether additional sensors will be necessary.

Jaundice in the full-term newborn.

PubMed

Cohen, Shannon Munro

2006-01-01

Jaundice is a common problem affecting over half of all full-term and most preterm infants. Jaundice describes the yellow orange hue of the skin caused by excessive circulating levels of bilirubin that accumulate in the skin. In most healthy full-term newborns, jaundice is noticed during the first week of life. Shortened hospital stays and inconsistent follow up, especially for first-time breastfeeding mothers, prompted the American Academy of Pediatrics (AAP) to update management guidelines. Health care providers need to be familiar with the diagnosis and management of jaundice to prevent brain, vision, and hearing damage. Treatment of choice for jaundice remains close observation and frequent feeding followed by phototherapy, and finally exchange transfusion for severe or refractory cases.

Potential of SENTINEL-1A for Nation-Wide Routine Updates of Active Landslide Maps

NASA Astrophysics Data System (ADS)

Lazecky, M.; Canaslan Comut, F.; Nikolaeva, E.; Bakon, M.; Papco, J.; Ruiz-Armenteros, A. M.; Qin, Y.; de Sousa, J. J. M.; Ondrejka, P.

2016-06-01

Slope deformation is one of the typical geohazards that causes an extensive economic damage in mountainous regions. As such, they are usually intensively monitored by means of modern expertise commonly by national geological or emergency services. Resulting landslide susceptibility maps, or landslide inventories, offer an overview of areas affected by previously activated landslides as well as slopes known to be unstable currently. Current slope instabilities easily transform into a landslide after various triggering factors, such as an intensive rainfall or a melting snow cover. In these inventories, the majority of the existing landslide-affected slopes are marked as either stable or active, after a continuous investigative work of the experts in geology. In this paper we demonstrate the applicability of Sentinel-1A satellite SAR interferometry (InSAR) to assist by identifying slope movement activity and use the information to update national landslide inventories. This can be done reliably in cases of semi-arid regions or low vegetated slopes. We perform several analyses based on multitemporal InSAR techniques of Sentinel-1A data over selected areas prone to landslides.

Orbiter Boundary Layer Transition Prediction Tool Enhancements

NASA Technical Reports Server (NTRS)

Berry, Scott A.; King, Rudolph A.; Kegerise, Michael A.; Wood, William A.; McGinley, Catherine B.; Berger, Karen T.; Anderson, Brian P.

2010-01-01

Updates to an analytic tool developed for Shuttle support to predict the onset of boundary layer transition resulting from thermal protection system damage or repair are presented. The boundary layer transition tool is part of a suite of tools that analyze the local aerothermodynamic environment to enable informed disposition of damage for making recommendations to fly as is or to repair. Using mission specific trajectory information and details of each d agmea site or repair, the expected time (and thus Mach number) of transition onset is predicted to help define proper environments for use in subsequent thermal and stress analysis of the thermal protection system and structure. The boundary layer transition criteria utilized within the tool were updated based on new local boundary layer properties obtained from high fidelity computational solutions. Also, new ground-based measurements were obtained to allow for a wider parametric variation with both protuberances and cavities and then the resulting correlations were calibrated against updated flight data. The end result is to provide correlations that allow increased confidence with the resulting transition predictions. Recently, a new approach was adopted to remove conservatism in terms of sustained turbulence along the wing leading edge. Finally, some of the newer flight data are also discussed in terms of how these results reflect back on the updated correlations.

Frequency Response Function Based Damage Identification for Aerospace Structures

NASA Astrophysics Data System (ADS)

Oliver, Joseph Acton

Structural health monitoring technologies continue to be pursued for aerospace structures in the interests of increased safety and, when combined with health prognosis, efficiency in life-cycle management. The current dissertation develops and validates damage identification technology as a critical component for structural health monitoring of aerospace structures and, in particular, composite unmanned aerial vehicles. The primary innovation is a statistical least-squares damage identification algorithm based in concepts of parameter estimation and model update. The algorithm uses frequency response function based residual force vectors derived from distributed vibration measurements to update a structural finite element model through statistically weighted least-squares minimization producing location and quantification of the damage, estimation uncertainty, and an updated model. Advantages compared to other approaches include robust applicability to systems which are heavily damped, large, and noisy, with a relatively low number of distributed measurement points compared to the number of analytical degrees-of-freedom of an associated analytical structural model (e.g., modal finite element model). Motivation, research objectives, and a dissertation summary are discussed in Chapter 1 followed by a literature review in Chapter 2. Chapter 3 gives background theory and the damage identification algorithm derivation followed by a study of fundamental algorithm behavior on a two degree-of-freedom mass-spring system with generalized damping. Chapter 4 investigates the impact of noise then successfully proves the algorithm against competing methods using an analytical eight degree-of-freedom mass-spring system with non-proportional structural damping. Chapter 5 extends use of the algorithm to finite element models, including solutions for numerical issues, approaches for modeling damping approximately in reduced coordinates, and analytical validation using a composite sandwich plate model. Chapter 6 presents the final extension to experimental systems-including methods for initial baseline correlation and data reduction-and validates the algorithm on an experimental composite plate with impact damage. The final chapter deviates from development and validation of the primary algorithm to discuss development of an experimental scaled-wing test bed as part of a collaborative effort for developing structural health monitoring and prognosis technology. The dissertation concludes with an overview of technical conclusions and recommendations for future work.

Modeling and Measuring the Effects of Radiation Damage Annealing on Helium Diffusion Kinetics in Apatite

NASA Astrophysics Data System (ADS)

Willett, C. D.; Fox, M.; Shuster, D. L.

2016-12-01

Understanding helium diffusion kinetics in apatite is critical for the accurate interpretation of (U-Th)/He thermochronometric data. This problem is complicated by the observation that helium diffusivity is not a simple function of temperature, but may evolve as a function of damage to the apatite crystal lattice resulting from alpha recoil. This `radiation damage' increases as a function of the amount of radiometric parent products, or effective uranium concentration, and time, but decreases due to thermal annealing of damage, necessitating a detailed understanding of radiation damage production and annealing in cases of burial heating over geologic timescales. Published observations [1,2] suggest that annealing rates of damage caused by alpha recoil and fission tracks in apatite differ. Existing models, however, assume the diffusion kinetics resulting from the two sources of damage are identical [3], demonstrating the need for further investigation of these damage sources. We present modeling and experimental work designed to interrogate the effects of radiation damage and its annealing on helium diffusion kinetics in apatite. Using previously published results [4] that investigated the effects of annealing temperature and duration on measured helium diffusivity, we fit a set of functions that are then integrated into a numerical model that tracks the evolution of radiation damage and apparent (U-Th)/He age. We compare the results of this model calibration to existing models [3]. In addition, we present data from two suites of diffusion experiments. The first suite, intended to test the published methodology and results, uses Durango apatite, while the second uses Sierran (CA) granite as a first test to determine if apatite of varying chemistry and age responds differently to the thermal annealing of radiation damage. Ultimately, the updated model and experimental results will benefit the interpretation of the effects of radiation damage accumulation and annealing in apatite and expand the range of geologic settings that can be studied using low-temperature thermochronology. References: [1] Fox, M., Shuster, D. (2014), EPSL 397, 174-183; [2] Gautheron, C. et al. (2013), Chem. Geol. 351, 257-267; [3] Flowers, R. et al. (2009), GCA 73, 2347-2365; [4] Shuster, D., Farley, K. (2009), GCA 73, 6183-6196.

Implication of general anaesthetic and sedation techniques in temporomandibular joint disorders - a systematic review.

PubMed

Talaván-Serna, J; Montiel-Company, J M; Bellot-Arcís, C; Almerich-Silla, J M

2017-02-01

The purpose of this study was to conduct a systematic review of the literature on temporomandibular joint damage directly related to general anaesthesia and sedation. We searched MEDLINE, SCOPUS and the COCHRANE Library for titles and abstracts containing terms related to the subject. The search delimiters were analytical and descriptive studies with abstracts in Spanish, German, English or French, with no time limit. The search was updated in January 2015. Of the 398 articles found, 89 were duplicates and only 28 were of interest. Of these, 23 (82.14%) were case and case series reports, 4 (14.28%) were longitudinal studies and 1 (3.57%) was a cross-sectional study. General anaesthesia and sedation are risk factors for temporomandibular joint damage because of the drop in muscle tone caused by the drugs employed and because of airway management manoeuvres involving the joint. Joint complications have been described with spontaneous ventilation as well as with ventilation assisted by a face or laryngeal mask and with intubation. They are more frequent in women and/or patients with previous temporomandibular problems. Proper assessment is required both before and after anaesthesia or sedation in order to foresee and avoid or minimize temporomandibular complications. The data should be treated with caution, as the evidence of case and case series reports is not of a high standard and the small number of analytical studies is not entirely comparable. General anaesthesia and sedation techniques can influence the onset of temporomandibular joint disorders. More studies are needed to provide better clinical evidence. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

About Heart Attacks

MedlinePlus

... Artery Disease Venous Thromboembolism Aortic Aneurysm More About Heart Attacks Updated:Jan 11,2018 A heart attack is ... coronary artery damage leads to a heart attack . Heart Attack Questions and Answers What is a heart attack? ...

Dynamic Data Driven Methods for Self-aware Aerospace Vehicles

DTIC Science & Technology

2015-04-08

structural response model that incorporates multiple degradation or failure modes including damaged panel strength (BVID, thru- hole ), damaged panel...stiffness (BVID, thru- hole ), loose fastener, fretted fastener hole , and disbonded surface. • A new data-driven approach for the online updating of the flight...between the first and second plies. The panels were reinforced around the boarders of the panel with through holes to simulate mounting the wing skins to

Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline.

PubMed

Vuurberg, Gwendolyn; Hoorntje, Alexander; Wink, Lauren M; van der Doelen, Brent F W; van den Bekerom, Michel P; Dekker, Rienk; van Dijk, C Niek; Krips, Rover; Loogman, Masja C M; Ridderikhof, Milan L; Smithuis, Frank F; Stufkens, Sjoerd A S; Verhagen, Evert A L M; de Bie, Rob A; Kerkhoffs, Gino M M J

2018-03-07

This guideline aimed to advance current understandings regarding the diagnosis, prevention and therapeutic interventions for ankle sprains by updating the existing guideline and incorporate new research. A secondary objective was to provide an update related to the cost-effectiveness of diagnostic procedures, therapeutic interventions and prevention strategies. It was posited that subsequent interaction of clinicians with this guideline could help reduce health impairments and patient burden associated with this prevalent musculoskeletal injury. The previous guideline provided evidence that the severity of ligament damage can be assessed most reliably by delayed physical examination (4-5 days post trauma). After correct diagnosis, it can be stated that even though a short time of immobilisation may be helpful in relieving pain and swelling, the patient with an acute lateral ankle ligament rupture benefits most from use of tape or a brace in combination with an exercise programme. New in this update: Participation in certain sports is associated with a heightened risk of sustaining a lateral ankle sprain. Care should be taken with non-steroidal anti-inflammatory drugs (NSAIDs) usage after an ankle sprain. They may be used to reduce pain and swelling, but usage is not without complications and NSAIDs may suppress the natural healing process. Concerning treatment, supervised exercise-based programmes preferred over passive modalities as it stimulates the recovery of functional joint stability. Surgery should be reserved for cases that do not respond to thorough and comprehensive exercise-based treatment. For the prevention of recurrent lateral ankle sprains, ankle braces should be considered as an efficacious option. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

DNA Damage and Oxidative Stress in Dyskeratosis Congenita: Analysis of Pathways and Therapeutic Stategies Using CPISPR and iPSC Model Systems

DTIC Science & Technology

2017-06-01

Milestone Achieved: HRPO/ACURO Approval 6 Finished Major Task 2 CRISPR knockout/RNAseq Viral infection/prep 3-6 CRISPR KO virus library prep...finished; RNA-Seq: ~75% Cell manipulation 3-6 CRISPR KO virus infection: 50%; Single cDNA infections: finished Bioinformatics 1 CRISPR KO library...characterization 1-3 Finished Update: production of iPSC clones harboring DC mutations generated by CRISPR : Design 1 Finished Update: production of

Current review of prepubertal vaginal bleeding.

PubMed

Dwiggins, Maggie; Gomez-Lobo, Veronica

2017-10-01

Prepubertal vaginal bleeding raises many concerns and evaluation and diagnosis may prove difficult for many providers. We aim to provide a comprehensive review and recent updates for those practitioners who care for these patients. Prompt management in the case of prepubertal vaginal bleeding is indicated, especially to rule out malignancy or abuse. If a child is reluctant to undergo examination, or if the extent of injury or source of bleeding cannot be determined, examination under anesthesia and vaginoscopy is recommended. Use of vaginoscopy allows for clear visualization of the vagina and cervix without distorting hymenal anatomy, as well as diagnosis and removal of a foreign body and evaluation of mucosal damage caused. In the case of sexual abuse, providers specifically trained in pediatrics need to be present, and safety of the patient should always be ensured. Careful history taking and targeted examination may lead to diagnosis in the case of prepubertal vaginal bleeding. However, in more difficult cases, practitioners should not hesitate to examine a patient in the operating room using general anesthesia to elicit the cause. Although sexual abuse and malignancy are always on the differential, most causes of bleeding are benign and easily treated.

Lawn mower injuries as a cause of serious visual acuity impairment - Case reports.

PubMed

Jasielska, Monika; Winiarczyk, Mateusz; Bieliński, Paweł; Mackiewicz, Jerzy

2017-05-11

[b]Abstract Objective.[/b] The aim of the study is to present four cases of lawn mowers injuries as a cause of serious visual acuity impairment. [b]Materials and Method[/b]. A retrospective study of four patients admitted in 2013-2015 to the Department of Vitreoretinal Surgery in Lublin with severe open or closed globe injury, one with an intraocular foreign body (IOFB). The presence of eye protective equipment was assessed, as well as visual acuity, eye tissue condition before and after treatment, and applied therapy. In all cases an improvement was achieved in local conditions. The intraocular foreign body was removed, wounds sutured and damaged tissues placed in position. All eyeballs were saved. In three cases, visual acuity was improved to a usable level. Three patients underwent pars plana vitrectomy, one with IOFB removal from the vitreous cavity. [b]Conclusions[/b]. Lawn mower induced eye injuries are a significant cause of serious visual acuity impairment or blindness. The presented study shows that lawn mower eye injuries are still a therapeutic, social and economic problem, yet are very preventable with proper eye protection and patients' education. Current prevention strategies are inadequate, and therefore should be updated.

Updated recommendations: an assessment of NICE clinical guidelines

PubMed Central

2014-01-01

Background Updating is important to ensure clinical guideline (CG) recommendations remain valid. However, little research has been undertaken in this field. We assessed CGs produced by the National Institute for Health and Care Excellence (NICE) to identify and describe updated recommendations and to investigate potential factors associated with updating. Also, we evaluated the reporting and presentation of recommendation changes. Methods We performed a descriptive analysis of original and updated CGs and recommendations, and an assessment of presentation formats and methods for recording information. We conducted a case-control study, defining cases as original recommendations that were updated (‘new-replaced’ recommendations), and controls as original recommendations that were considered to remain valid (‘not changed’ recommendations). We performed a comparison of main characteristics between cases and controls, and we planned a multiple regression analysis to identify potential predictive factors for updating. Results We included nine updated CGs (1,306 recommendations) and their corresponding original versions (1,106 recommendations). Updated CGs included 812 (62%) recommendations ‘not reviewed’, 368 (28.1%) ‘new’ recommendations, 104 (7.9%) ‘amended’ recommendations, and 25 (1.9%) recommendations reviewed but unchanged. The presentation formats used to indicate the changes in recommendations varied widely across CGs. Changes in ‘amended’, ‘deleted’, and ‘new-replaced’ recommendations (n = 296) were reported infrequently, mostly in appendices. These changes were recorded in 167 (56.4%) recommendations; and were explained in 81 (27.4%) recommendations. We retrieved a total of 7.1% (n = 78) case recommendations (‘new-replaced’) and 2.4% (n = 27) control recommendations (‘not changed’) in original CGs. The updates were mainly from ‘Fertility CG’, about ‘gynaecology, pregnancy and birth’ topic, and ‘treatment’ or ‘prevention’ purposes. We did not perform the multiple regression analysis as originally planned due to the small sample of recommendations retrieved. Conclusion Our study is the first to describe and assess updated CGs and recommendations from a national guideline program. Our results highlight the pressing need to standardise the reporting and presentation of updated recommendations and the research gap about the optimal way to present updates to guideline users. Furthermore, there is a need to investigate updating predictive factors. PMID:24919856

Benefits of Model Updating: A Case Study Using the Micro-Precision Interferometer Testbed

NASA Technical Reports Server (NTRS)

Neat, Gregory W.; Kissil, Andrew; Joshi, Sanjay S.

1997-01-01

This paper presents a case study on the benefits of model updating using the Micro-Precision Interferometer (MPI) testbed, a full-scale model of a future spaceborne optical interferometer located at JPL.

Search and Seizure of Students in Public Schools: 2002 Update of Fourth Amendment Cases.

ERIC Educational Resources Information Center

Stefkovich, Jacqueline A.

This paper presents court cases for the purpose of updating current knowledge on search and seizure of students in the school setting. These cases focus on the balance and interplay between students' Fourth Amendment rights and school administrators' obligations to maintain order and discipline in the schools. Part of this obligation implies…

Detector Damage at X-Ray Free-Electron Laser Sources

NASA Astrophysics Data System (ADS)

Blaj, G.; Carini, G.; Carron, S.; Haller, G.; Hart, P.; Hasi, J.; Herrmann, S.; Kenney, C.; Segal, J.; Stan, C. A.; Tomada, A.

2016-06-01

Free-electron lasers (FELs) opened a new window on imaging the motion of atoms and molecules. At SLAC, FEL experiments are performed at LCLS using 120 Hz pulses with 1012 to 1013 photons in 10 fs (billions of times brighter than at the most powerful synchrotrons). Concurrently, users and staff operate under high pressure due to flexible and often rapidly changing setups and low tolerance for system malfunction. This extreme detection environment raises unique challenges, from obvious to surprising, and leads to treating detectors as consumables. We discuss in detail the detector damage mechanisms observed in 7 years of operation at LCLS, together with the corresponding damage mitigation strategies and their effectiveness. Main types of damage mechanisms already identified include: (1) x-ray radiation damage (from “catastrophic” to “classical”), (2) direct and indirect damage caused by optical lasers, (3) sample induced damage, (4) vacuum related damage, (5) high-pressure environment. In total, 19 damage mechanisms have been identified. We also present general strategies for reducing damage risk or minimizing the impact of detector damage on the science program. These include availability of replacement parts and skilled operators and also careful planning, incident investigation resulting in updated designs, procedures and operator training.

Estimation of probability of failure for damage-tolerant aerospace structures

NASA Astrophysics Data System (ADS)

Halbert, Keith

The majority of aircraft structures are designed to be damage-tolerant such that safe operation can continue in the presence of minor damage. It is necessary to schedule inspections so that minor damage can be found and repaired. It is generally not possible to perform structural inspections prior to every flight. The scheduling is traditionally accomplished through a deterministic set of methods referred to as Damage Tolerance Analysis (DTA). DTA has proven to produce safe aircraft but does not provide estimates of the probability of failure of future flights or the probability of repair of future inspections. Without these estimates maintenance costs cannot be accurately predicted. Also, estimation of failure probabilities is now a regulatory requirement for some aircraft. The set of methods concerned with the probabilistic formulation of this problem are collectively referred to as Probabilistic Damage Tolerance Analysis (PDTA). The goal of PDTA is to control the failure probability while holding maintenance costs to a reasonable level. This work focuses specifically on PDTA for fatigue cracking of metallic aircraft structures. The growth of a crack (or cracks) must be modeled using all available data and engineering knowledge. The length of a crack can be assessed only indirectly through evidence such as non-destructive inspection results, failures or lack of failures, and the observed severity of usage of the structure. The current set of industry PDTA tools are lacking in several ways: they may in some cases yield poor estimates of failure probabilities, they cannot realistically represent the variety of possible failure and maintenance scenarios, and they do not allow for model updates which incorporate observed evidence. A PDTA modeling methodology must be flexible enough to estimate accurately the failure and repair probabilities under a variety of maintenance scenarios, and be capable of incorporating observed evidence as it becomes available. This dissertation describes and develops new PDTA methodologies that directly address the deficiencies of the currently used tools. The new methods are implemented as a free, publicly licensed and open source R software package that can be downloaded from the Comprehensive R Archive Network. The tools consist of two main components. First, an explicit (and expensive) Monte Carlo approach is presented which simulates the life of an aircraft structural component flight-by-flight. This straightforward MC routine can be used to provide defensible estimates of the failure probabilities for future flights and repair probabilities for future inspections under a variety of failure and maintenance scenarios. This routine is intended to provide baseline estimates against which to compare the results of other, more efficient approaches. Second, an original approach is described which models the fatigue process and future scheduled inspections as a hidden Markov model. This model is solved using a particle-based approximation and the sequential importance sampling algorithm, which provides an efficient solution to the PDTA problem. Sequential importance sampling is an extension of importance sampling to a Markov process, allowing for efficient Bayesian updating of model parameters. This model updating capability, the benefit of which is demonstrated, is lacking in other PDTA approaches. The results of this approach are shown to agree with the results of the explicit Monte Carlo routine for a number of PDTA problems. Extensions to the typical PDTA problem, which cannot be solved using currently available tools, are presented and solved in this work. These extensions include incorporating observed evidence (such as non-destructive inspection results), more realistic treatment of possible future repairs, and the modeling of failure involving more than one crack (the so-called continuing damage problem). The described hidden Markov model / sequential importance sampling approach to PDTA has the potential to improve aerospace structural safety and reduce maintenance costs by providing a more accurate assessment of the risk of failure and the likelihood of repairs throughout the life of an aircraft.

School Officials and the Courts: Update 2001. ERS Monograph.

ERIC Educational Resources Information Center

Thompson, David P.; Hartmeister, Fredric J.

This is the 22nd in a series of yearly updates of judicial decision summaries for case law related to elementary and secondary education issues. One can use previous and future editions to track decisions on appeal or to see trends in case law. With few exceptions, the cases were selected from court decisions found in federal and regional…

School Officials and the Courts: Update 2002. ERS Monograph.

ERIC Educational Resources Information Center

Thompson, David P.; Hartmeister, Fredric J.

This is the 23rd in a series of yearly updates of judicial decision summaries for case law related to elementary- and secondary-education issues. One can use previous and future editions to track decisions on appeal or to spot trends in case law. With few exceptions, the cases were selected from court decisions found in federal and regional…

Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review.

PubMed

Asproudis, Ioannis; Katsanos, Andreas; Kozeis, Nikolaos; Tantou, Alexandra; Konstas, Anastasios G

2017-12-01

Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile idiopathic arthritis is initially limited in the anterior part of the eye, chronic active inflammation may eventually cause significant damage to the posterior pole. Complications may include band keratopathy, cataract, secondary glaucoma, posterior synechiae, cystoid macular edema, and hypotony. The cooperation of ophthalmologists with rheumatologists may help define the best treatment plan. The ophthalmic therapeutic regimen includes topical corticosteroids and mydriatics, while in severe cases immunosuppressive and biological agents are introduced. Surgical management of complications might be needed.

Structural Health Monitoring of Large Structures

NASA Technical Reports Server (NTRS)

Kim, Hyoung M.; Bartkowicz, Theodore J.; Smith, Suzanne Weaver; Zimmerman, David C.

1994-01-01

This paper describes a damage detection and health monitoring method that was developed for large space structures using on-orbit modal identification. After evaluating several existing model refinement and model reduction/expansion techniques, a new approach was developed to identify the location and extent of structural damage with a limited number of measurements. A general area of structural damage is first identified and, subsequently, a specific damaged structural component is located. This approach takes advantage of two different model refinement methods (optimal-update and design sensitivity) and two different model size matching methods (model reduction and eigenvector expansion). Performance of the proposed damage detection approach was demonstrated with test data from two different laboratory truss structures. This space technology can also be applied to structural inspection of aircraft, offshore platforms, oil tankers, ridges, and buildings. In addition, its applications to model refinement will improve the design of structural systems such as automobiles and electronic packaging.

Adaptability to Changes in Temporal Structure Is Fornix-Dependent

ERIC Educational Resources Information Center

Kwok, Sze Chai; Mitchell, Anna S.; Buckley, Mark J.

2015-01-01

Recognition memory deficits, even after short delays, are sometimes observed following hippocampal damage. One hypothesis links the hippocampus with processes in updating contextual memory representation. Here, we used fornix transection, which partially disconnects the hippocampal system, and compares the performance of fornix-transected monkeys…

Adaptability to Changes Intemporal Structure Is Fornix-Dependent

ERIC Educational Resources Information Center

Kwok, Sze Chai; Mitchell, Anna S.; Buckley, Mark J.

2015-01-01

Recognition memory deficits, even after short delays, are sometimes observed following hippocampal damage. One hypothesis links the hippocampus with processes in updating contextual memory representation. Here, we used fornix transection, which partially disconnects the hippocampal system, and compares the performance of fornix-transected monkeys…

77 FR 35921 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211, 212, 218, 246, 252 and Appendix F to Chapter 2 RIN 0750-AH64 Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011-D055) AGENCY: Defense Acquisition Regulations System...

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

PubMed Central

Félix-Silva, Juliana; Silva-Junior, Arnóbio Antônio; Zucolotto, Silvana Maria

2017-01-01

Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage. PMID:28904556

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.

PubMed

Félix-Silva, Juliana; Silva-Junior, Arnóbio Antônio; Zucolotto, Silvana Maria; Fernandes-Pedrosa, Matheus de Freitas

2017-01-01

Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.

Updates to building-code maps for the 2015 NEHRP recommended seismic provisions

USGS Publications Warehouse

Luco, Nicolas; Bachman, Robert; Crouse, C.B; Harris, James R.; Hooper, John D.; Kircher, Charles A.; Caldwell, Phillp; Rukstales, Kenneth S.

2015-01-01

With the 2014 update of the U.S. Geological Survey (USGS) National Seismic Hazard Model (NSHM) as a basis, the Building Seismic Safety Council (BSSC) has updated the earthquake ground motion maps in the National Earthquake Hazards Reduction Program (NEHRP) Recommended Seismic Provisions for New Buildings and Other Structures, with partial funding from the Federal Emergency Management Agency. Anticipated adoption of the updated maps into the American Society of Civil Engineers Minimum Design Loads for Building and Other Structures and the International Building and Residential Codes is underway. Relative to the ground motions in the prior edition of each of these documents, most of the updated values are within a ±20% change. The larger changes are, in most cases, due to the USGS NSHM updates, reasons for which are given in companion publications. In some cases, the larger changes are partly due to a BSSC update of the slope of the fragility curve that is used to calculate the risk-targeted ground motions, and/or the introduction by BSSC of a quantitative definition of “active faults” used to calculate deterministic ground motions.

76 FR 68525 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-04

...This final rule sets forth updates to the home health prospective payment system (HH PPS) rates, including: the national standardized 60-day episode rates; the national per-visit rates; and the low utilization payment amount (LUPA) under the Medicare PPS for home health agencies effective January 1, 2012. This rule applies a 1.4 percent update factor to the episode rates, which reflects a 1 percent reduction applied to the 2.4 percent market basket update factor, as mandated by the Affordable Care Act. This rule also updates the wage index used under the HH PPS, and further reduces home health payments to account for continued nominal growth in case-mix which is unrelated to changes in patient health status. This rule removes two hypertension codes from the HH PPS case-mix system, thereby requiring recalibration of the case-mix weights. In addition, the rule implements two structural changes designed to decrease incentives to upcode and provide unneeded therapy services. Finally, this rule incorporates additional flexibility regarding face-to-face encounters with providers related to home health care.

Medicare program; home health prospective payment system rate update for calendar year 2012. Final rule.

PubMed

2011-11-04

This final rule sets forth updates to the home health prospective payment system (HH PPS) rates, including: the national standardized 60-day episode rates; the national per-visit rates; and the low utilization payment amount (LUPA) under the Medicare PPS for home health agencies effective January 1, 2012. This rule applies a 1.4 percent update factor to the episode rates, which reflects a 1 percent reduction applied to the 2.4 percent market basket update factor, as mandated by the Affordable Care Act. This rule also updates the wage index used under the HH PPS, and further reduces home health payments to account for continued nominal growth in case-mix which is unrelated to changes in patient health status. This rule removes two hypertension codes from the HH PPS case-mix system, thereby requiring recalibration of the case-mix weights. In addition, the rule implements two structural changes designed to decrease incentives to upcode and provide unneeded therapy services. Finally, this rule incorporates additional flexibility regarding face-to-face encounters with providers related to home health care.

SPH calculations of asteroid disruptions: The role of pressure dependent failure models

NASA Astrophysics Data System (ADS)

Jutzi, Martin

2015-03-01

We present recent improvements of the modeling of the disruption of strength dominated bodies using the Smooth Particle Hydrodynamics (SPH) technique. The improvements include an updated strength model and a friction model, which are successfully tested by a comparison with laboratory experiments. In the modeling of catastrophic disruptions of asteroids, a comparison between old and new strength models shows no significant deviation in the case of targets which are initially non-porous, fully intact and have a homogeneous structure (such as the targets used in the study by Benz and Asphaug, 1999). However, for many cases (e.g. initially partly or fully damaged targets and rubble-pile structures) we find that it is crucial that friction is taken into account and the material has a pressure dependent shear strength. Our investigations of the catastrophic disruption threshold Q D * as a function of target properties and target sizes up to a few 100 km show that a fully damaged target modeled without friction has a Q D * which is significantly (5-10 times) smaller than in the case where friction is included. When the effect of the energy dissipation due to compaction (pore crushing) is taken into account as well, the targets become even stronger ( Q D * is increased by a factor of 2-3). On the other hand, cohesion is found to have an negligible effect at large scales and is only important at scales ≲ 1 km. Our results show the relative effects of strength, friction and porosity on the outcome of collisions among small (≲ 1000 km) bodies. These results will be used in a future study to improve existing scaling laws for the outcome of collisions (e.g. Leinhardt and Stewart, 2012).

RCRA, Superfund and EPCRA hotline training module. Introduction to: the Superfund response program (updated February 1998); Directive

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

This module includes the following: Regulatory Summary (Definitions; National Contingency Plan; Notification or Discovery; Response Process; Removal Process; Remedial Process; Community Involvement; State Role; Natural Resource Damage Assessments; Federal Facility Response; and Contractor Support); and Module Summary.

EEG Correlates of Preparatory Orienting, Contextual Updating, and Inhibition of Sensory Processing in Left Spatial Neglect.

PubMed

Lasaponara, Stefano; D'Onofrio, Marianna; Pinto, Mario; Dragone, Alessio; Menicagli, Dario; Bueti, Domenica; De Lucia, Marzia; Tomaiuolo, Francesco; Doricchi, Fabrizio

2018-04-11

Studies with event-related potentials have highlighted deficits in the early phases of orienting to left visual targets in right-brain-damaged patients with left spatial neglect (N+). However, brain responses associated with preparatory orienting of attention, with target novelty and with the detection of a match/mismatch between expected and actual targets (contextual updating), have not been explored in N+. Here in a study in healthy humans and brain-damaged patients of both sexes we demonstrate that frontal activity that reflects supramodal mechanisms of attentional orienting (Anterior Directing Attention Negativity, ADAN) is entirely spared in N+. In contrast, posterior responses that mark the early phases of cued orienting (Early Directing Attention Negativity, EDAN) and the setting up of sensory facilitation over the visual cortex (Late Directing Attention Positivity, LDAP) are suppressed in N+. This uncoupling is associated with damage of parietal-frontal white matter. N+ also exhibit exaggerated novelty reaction to targets in the right side of space and reduced novelty reaction for those in the left side (P3a) together with impaired contextual updating (P3b) in the left space. Finally, we highlight a drop in the amplitude and latency of the P1 that over the left hemisphere signals the early blocking of sensory processing in the right space when targets occur in the left one: this identifies a new electrophysiological marker of the rightward attentional bias in N+. The heterogeneous effects and spatial biases produced by localized brain damage on the different phases of attentional processing indicate relevant functional independence among their underlying neural mechanisms and improve the understanding of the spatial neglect syndrome. SIGNIFICANCE STATEMENT Our investigation answers important questions: are the different components of preparatory orienting (EDAN, ADAN, LDAP) functionally independent in the healthy brain? Is preparatory orienting of attention spared in left spatial neglect? Does the sparing of preparatory orienting have an impact on deficits in reflexive orienting and in the assignment of behavioral relevance to the left space? We show that supramodal preparatory orienting in frontal areas is entirely spared in neglect patients though this does not counterbalance deficits in preparatory parietal-occipital activity, reflexive orienting, and contextual updating. This points at relevant functional dissociations among different components of attention and suggests that improving voluntary attention in N+ might be behaviorally ineffective unless associated with stimulations boosting the response of posterior parietal-occipital areas. Copyright © 2018 the authors 0270-6474/18/383792-17$15.00/0.

26 CFR 301.7426-2 - Recovery of damages in certain cases.

Code of Federal Regulations, 2010 CFR

2010-04-01

... in the case of negligence), or the sum of— (1) Actual, direct economic damages as defined in § 301... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Recovery of damages in certain cases. 301.7426... the United States § 301.7426-2 Recovery of damages in certain cases. (a) In general. In addition to...

Helicobacter heilmannii-associated Gastritis: Clinicopathologic Findings and Comparison with Helicobacter pylori-associated Gastritis

PubMed Central

Kwak, Ji Eun; Chang, Sun Hee; Kim, Hanseong; Chi, Je G.; Kim, Kyung-Ah; Yang, Jeon Ho; Lee, June Sung; Moon, Young-Soo; Kim, Kyoung-Mee

2007-01-01

The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastritis groups. There were 10 cases of H. heilmannii-associated gastritis (0.17%) and 3,285 cases of H. pylori-associated gastritis (54.9%). The organisms were superficially located within the mucous layer without adhesion to epithelial cells. Interestingly, in one case many intracytoplasmic H. heilmannii organisms were observed in parietal cells with cell damage. A case of low-grade mucosa-associated lymphoid tissue (MALT) lymphoma concomitant with H. heilmannii infection was detected. Compared to H. pylori-associated gastritis, H. heilmannii-associated gastritis showed less severe neutrophilic activity (p<0.0001), mononuclear cell infiltration (p=0.0029), and endoscopic findings of chronic gastritis devoid of erosion or ulcer (p=0.0309). In conclusion, we present the detailed clinicopathologic findings of H. heilmannii-associated gastritis compared to H. pylori-associated gastritis. H. heilmannii-associated gastritis is uncommon and milder than H. pylori-associated gastritis, however it may be noteworthy with respect to the development of MALT lymphoma. PMID:17297253

Systematic analysis of nonlinear ground motion and temporal changes of material properties produced by small and medium earthquakes

NASA Astrophysics Data System (ADS)

Wu, C.; Peng, Z.; Ben-Zion, Y.

2009-12-01

Recent studies based on spectral ratio analysis have found clear temporal changes of material properties in the shallow crust and around active fault zones during large earthquakes with peak ground acceleration (PGA) larger than 100-200 gals (e.g., Sawazaki et al., GRL, 2006; Rubenstein et al., JGR, 2007; Wu et al., GJI, 2009). The temporal evolution of properties is generally characterized by a clear drop of resonant frequency and increased damping, followed by logarithmic recoveries with time. The shift in resonant frequency and damping are considered two hallmarks of nonlinear response associated with increasing material damage. However, an existing damage can produce similar changes in resonance curves with increasing wave amplitude, even in cases when the material damage does not increase (Lyakhovsky et al., GJI, 2009). In such cases the recovery of resonance properties with reduced source amplitude should be essentially instantaneous. It is important to distinguish with in situ seismic data nonlinear wave propagation effects that reflect fixed vs. evolving material damage. Here we systematically analyze temporal changes of material properties and nonlinear response associated with small and medium earthquakes, using seismic data recorded by the Japanese Strong Motion Network KIK-Net, a temporary 10-station PASSCAL seismic network along the North Anatolian Fault in Turkey, and the borehole and surface stations around the Parkfield section of the San Andreas fault. We compute the spectral ratios of windowed records from a pair of target and reference stations, and apply the sliding-window to the entire seismic records including the pre-event noise, P and S waves, and the early and late S-coda waves. We choose small and medium events to reduce the effects from additional material damage and use small sliding-window size to capture the subtle changes in the spectral ratios. The spectral ratio traces from windows within certain PGA ranges are then stacked to enhance the stability of the results. The preliminary results from the KIK-Net data suggest that the resonant frequency starts to decrease for PGA levels of several tens of gals, followed by near instantaneous recovery. Updated results from analysis of all the datasets will be presented in the meeting.

Update of Forest Service Research Data

Treesearch

Terence L. Wagner

2002-01-01

The U.S. Forest Service undertakes research to improve the protection of wood products against subterranean termite damage, define the role of termites in forest ecosystems, and understand their impact on forest health. Specifically, the Wood Products Insect Research Unit concentrates efforts on developing, refining, and assessing new and alternative compounds,...

78 FR 40069 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... and an updated fatigue and damage tolerance analysis that the risk for fatigue cracking on the front... and correct fatigue cracks in the bolt holes of the wing spars, which could result in reduced..., between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. For service information...

GSD Update: Strategies for understanding and controlling species invasions

Treesearch

Deborah M. Finch

2013-01-01

Invasive species are significant environmental and economic threats to our Nation's and the world's ecosystems and natural resources. They impact wildlife habitat, endanger native species, threaten ecosystem services, damage lakes and rivers, reduce recreational opportunities, affect production of wood products, jeopardize human health and safety and reduce...

Influenza virus vaccine for neglected hosts: horses and dogs

PubMed Central

2016-01-01

This study provides information regarding vaccine research and the epidemiology of influenza virus in neglected hosts (horses and dogs). Equine influenza virus (EIV) causes a highly contagious disease in horses and other equids, and outbreaks have occurred worldwide. EIV has resulted in costly damage to the horse industry and has the ability of cross the host species barrier from horses to dogs. Canine influenza is a virus of equine or avian origin and infects companion animals that live in close contact with humans; this results in possible exposure to the seasonal epizootic influenza virus. There have been case reports of genetic reassortment between human and canine influenza viruses, which results in high virulence and the ability of transmission to ferrets. This emphasizes the need for vaccine research on neglected hosts to update knowledge on current strains and to advance technology for controlling influenza outbreaks for public health. PMID:27489801

Mesenchymal stem-cell potential in cartilage repair: an update

PubMed Central

Mazor, M; Lespessailles, E; Coursier, R; Daniellou, R; Best, T M; Toumi, H

2014-01-01

Articular cartilage damage and subsequent degeneration are a frequent occurrence in synovial joints. Treatment of these lesions is a challenge because this tissue is incapable of quality repair and/or regeneration to its native state. Non-operative treatments endeavour to control symptoms and include anti-inflammatory medications, viscosupplementation, bracing, orthotics and activity modification. Classical surgical techniques for articular cartilage lesions are frequently insufficient in restoring normal anatomy and function and in many cases, it has not been possible to achieve the desired results. Consequently, researchers and clinicians are focusing on alternative methods for cartilage preservation and repair. Recently, cell-based therapy has become a key focus of tissue engineering research to achieve functional replacement of articular cartilage. The present manuscript is a brief review of stem cells and their potential in the treatment of early OA (i.e. articular cartilage pathology) and recent progress in the field. PMID:25353372

Project of Near-Real-Time Generation of ShakeMaps and a New Hazard Map in Austria

NASA Astrophysics Data System (ADS)

Jia, Yan; Weginger, Stefan; Horn, Nikolaus; Hausmann, Helmut; Lenhardt, Wolfgang

2016-04-01

Target-orientated prevention and effective crisis management can reduce or avoid damage and save lives in case of a strong earthquake. To achieve this goal, a project for automatic generated ShakeMaps (maps of ground motion and shaking intensity) and updating the Austrian hazard map was started at ZAMG (Zentralanstalt für Meteorologie und Geodynamik) in 2015. The first goal of the project is set for a near-real-time generation of ShakeMaps following strong earthquakes in Austria to provide rapid, accurate and official information to support the governmental crisis management. Using newly developed methods and software by SHARE (Seismic Hazard Harmonization in Europe) and GEM (Global Earthquake Model), which allows a transnational analysis at European level, a new generation of Austrian hazard maps will be ultimately calculated. More information and a status of our project will be given by this presentation.

[Ubiquitin-proteasome system and sperm DNA repair: An update].

PubMed

Zhang, Guo-Wei; Cai, Hong-Cai; Shang, Xue-Jun

2016-09-01

The ubiquitin-proteasome system (UPS) is a proteasome system widely present in the human body, which is composed of ubiquitin (Ub), ubiquitin activating enzymes (E1), ubiquitin conjugating enzymes (E2), ubiquitin protein ligases (E3), 26S proteasome, and deubiquitinating enzymes (DUBs) and involved in cell cycle regulation, immune response, signal transduction, DNA repair as well as protein degradation. Sperm DNA is vulnerable to interference or damage in the progression of chromosome association and homologous recombination. Recent studies show that UPS participates in DNA repair in spermatogenesis by modulating DNA repair enzymes via ubiquitination, assisting in the identification of DNA damage sites, raising damage repair-related proteins, initiating the DNA repair pathway, maintaining chromosome stability, and ensuring the normal process of spermatogenesis.

Near Real-Time Applications of Earth Remote Sensing for Response to Meteorological Disasters

NASA Technical Reports Server (NTRS)

Molthan, Andrew L.; Burks, Jason E.; McGrath, Kevin M.; Bell, Jordan R.

2013-01-01

Numerous on-orbit satellites provide a wide range of spatial, spectral, and temporal resolutions supporting the use of their resulting imagery in assessments of disasters that are meteorological in nature. This presentation will provide an overview of recent use of Earth remote sensing by NASA's Short-term Prediction Research and Transition (SPoRT) Center in response to disaster activities in 2012 and 2013, along with case studies supporting ongoing research and development. The SPoRT Center, with support from NASA's Applied Sciences Program, has explored a variety of new applications of Earth-observing sensors to support disaster response. In May 2013, the SPoRT Center developed unique power outage composites representing the first clear sky view of damage inflicted upon Moore and Oklahoma City, Oklahoma following the devastating EF-5 tornado that occurred on May 20. Subsequent ASTER, MODIS, Landsat-7 and Landsat-8 imagery help to identify the damaged area. Higher resolution imagery of Moore, Oklahoma were provided by commercial satellites and the recently available International Space Station (ISS) SERVIR Environmental Research and Visualization System (ISERV) instrument. New techniques are being explored by the SPoRT team in order to better identify damage visible in high resolution imagery, and to monitor ongoing recovery for Moore, Oklahoma. Other applications are being developed to refine light source detections with the VIIRS day-night band and to map hail during the growing season through combination of available satellite and radar imagery. The aforementioned products and support are not useful unless they are distributed in a timely manner and within an appropriate decision support system. This presentation will provide an update on ongoing activities to support inclusion of these data sets within the NOAA National Weather Service Damage Assessment Toolkit, which allows meteorologists in the field to consult available satellite imagery while performing their damage assessment.

Near Real-­Time Applications of Earth Remote Sensing for Response to Meteorological Disasters

NASA Technical Reports Server (NTRS)

Molthan, Andrew L.; Burks, Jason E.; McGrath, Kevin M.; Bell, Jordan R.

2013-01-01

Numerous on-orbit satellites provide a wide range of spatial, spectral, and temporal resolutions supporting the use of their resulting imagery in assessments of disasters that are meteorological in nature. This presentation will provide an overview of recent use of Earth remote sensing by NASA's Short-term Prediction Research and Transition (SPoRT) Center in response to disaster activities in 2012 and 2013, along with case studies supporting ongoing research and development. The SPoRT Center, with support from NASA's Applied Sciences Program, has explored a variety of new applications of Earth-observing sensors to support disaster response. In May 2013, the SPoRT Center developed unique power outage composites representing the first clear sky view of damage inflicted upon Moore and Oklahoma City, Oklahoma following the devastating EF-5 tornado that occurred on May 20. Subsequent ASTER, MODIS, Landsat-7 and Landsat-8 imagery help to identify the damaged area. Higher resolution imagery of Moore, Oklahoma were provided by commercial satellites and the recently available International Space Station (ISS) SERVIR Environmental Research and Visualization System (ISERV) instrument. New techniques are being explored by the SPoRT team in order to better identify damage visible in high resolution imagery, and to monitor ongoing recovery for Moore, Oklahoma. Other applications are being developed to refine light source detections with the VIIRS day-night band and to map hail during the growing season through combination of available satellite and radar imagery. The aforementioned products and support are not useful unless they are distributed in a timely manner and within an appropriate decision support system. This presentation will provide an update on ongoing activities to support inclusion of these data sets within the NOAA National Weather Service Damage Assessment Toolkit, which allows meteorologists in the field to consult available satellite imagery while performing their damage assessment.

An update on the management of Budd-Chiari syndrome: the issues of timing and choice of treatment.

PubMed

Mancuso, Andrea

2015-03-01

Because of the rarity of Budd-Chiari syndrome (BCS), the flow chart of management comes from expert opinion and is not evidence based. To report an update on the management of BCS. I performed a review on published papers on BCS in an attempt to speculate in particular on the timing and the choice of treatment. Some authors suggest that the management of BCS should follow a step-wise strategy. Anticoagulation and medical therapy should be the first-line treatment. Revascularization or transjugular intrahepatic portosystemic shunt should be performed in case of no response to medical therapy. Orthotopic liver transplant should be used as a rescue therapy. The biggest criticism of this flow chart is that it is based on the assumption that patients with BCS should receive further treatment only when hemodynamic effects on portal hypertension become clinically evident, thus paying little attention to the chronic ischemic liver damage effects on hepatic function and to the possibility of preventing liver failure by relieving impaired hepatic veins outflow. Recently, I presented a proposal of a new algorithm for the management of BCS, in which medical therapy alone is suggested only for patients without any sign of portal hypertension, irrespective of whether early interventional treatment is suggested when either any symptoms or signs of portal hypertension appear, with the aim of preventing hepatic fibrosis development, disease progression, and finally improving outcome. Given that the benefit of treatments for BCS is not under debate, guidelines for the management of BCS should be re-evaluated and updated, with particular attention to both the timing and the choice of treatment.

76 FR 71928 - Defense Federal Acquisition Regulation Supplement; Updates to Wide Area WorkFlow (DFARS Case 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... Defense Federal Acquisition Regulation Supplement; Updates to Wide Area WorkFlow (DFARS Case 2011-D027... Wide Area WorkFlow (WAWF) and TRICARE Encounter Data System (TEDS). WAWF, which electronically... civil emergencies, when access to Wide Area WorkFlow by those contractors is not feasible; (4) Purchases...

2014 Bone and Muscle Risks Standing Review Panel

NASA Technical Reports Server (NTRS)

Steinberg, Susan; Glowacki, Julie; Gregor, Robert; Cullen, Diane; Drake, Almond; Enoka, Roger; Hanley, Edward Jr.; Kraemer, William; Raven, Peter; Sumner, Rick, D.

2014-01-01

The 2014 Bone and Muscle Risks Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on December 17 - 18, 2014. The SRP reviewed the updated research plans for the Risk of Impaired Performance Due to Reduced Muscle Mass, Strength and Endurance (Muscle Risk) and the Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity (Aerobic Risk). The SRP also received a status update on the Risk of Bone Fracture (Bone Risk), the Risk of Early Onset Osteoporosis Due To Spaceflight (Osteo Risk), the Risk of Intervertebral Disc Damage (IVD Risk), and the Risk of Renal Stone Formation (Renal Risk).

42 CFR 412.328 - Determining and updating the hospital-specific rate.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-year cost reporting period—(1) Last 12 month cost reporting period ending on or before December 31... intermediary updates the case-mix adjusted base period costs per discharge to FY 1992 based on the national... determined under paragraph (d) of this section by the following factors: (1) Update factor. After FY 1992...

42 CFR 412.328 - Determining and updating the hospital-specific rate.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-year cost reporting period—(1) Last 12 month cost reporting period ending on or before December 31... intermediary updates the case-mix adjusted base period costs per discharge to FY 1992 based on the national... determined under paragraph (d) of this section by the following factors: (1) Update factor. After FY 1992...

42 CFR 412.328 - Determining and updating the hospital-specific rate.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-year cost reporting period—(1) Last 12 month cost reporting period ending on or before December 31... intermediary updates the case-mix adjusted base period costs per discharge to FY 1992 based on the national... determined under paragraph (d) of this section by the following factors: (1) Update factor. After FY 1992...

42 CFR 412.328 - Determining and updating the hospital-specific rate.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-year cost reporting period—(1) Last 12 month cost reporting period ending on or before December 31... intermediary updates the case-mix adjusted base period costs per discharge to FY 1992 based on the national... determined under paragraph (d) of this section by the following factors: (1) Update factor. After FY 1992...

System for estimating fatigue damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

LeMonds, Jeffrey; Guzzo, Judith Ann; Liu, Shaopeng

In one aspect, a system for estimating fatigue damage in a riser string is provided. The system includes a plurality of accelerometers which can be deployed along a riser string and a communications link to transmit accelerometer data from the plurality of accelerometers to one or more data processors in real time. With data from a limited number of accelerometers located at sensor locations, the system estimates an optimized current profile along the entire length of the riser including riser locations where no accelerometer is present. The optimized current profile is then used to estimate damage rates to individual risermore » components and to update a total accumulated damage to individual riser components. The number of sensor locations is small relative to the length of a deepwater riser string, and a riser string several miles long can be reliably monitored along its entire length by fewer than twenty sensor locations.« less

Normal response function method for mass and stiffness matrix updating using complex FRFs

NASA Astrophysics Data System (ADS)

Pradhan, S.; Modak, S. V.

2012-10-01

Quite often a structural dynamic finite element model is required to be updated so as to accurately predict the dynamic characteristics like natural frequencies and the mode shapes. Since in many situations undamped natural frequencies and mode shapes need to be predicted, it has generally been the practice in these situations to seek updating of only mass and stiffness matrix so as to obtain a reliable prediction model. Updating using frequency response functions (FRFs) has been one of the widely used approaches for updating, including updating of mass and stiffness matrices. However, the problem with FRF based methods, for updating mass and stiffness matrices, is that these methods are based on use of complex FRFs. Use of complex FRFs to update mass and stiffness matrices is not theoretically correct as complex FRFs are not only affected by these two matrices but also by the damping matrix. Therefore, in situations where updating of only mass and stiffness matrices using FRFs is required, the use of complex FRFs based updating formulation is not fully justified and would lead to inaccurate updated models. This paper addresses this difficulty and proposes an improved FRF based finite element model updating procedure using the concept of normal FRFs. The proposed method is a modified version of the existing response function method that is based on the complex FRFs. The effectiveness of the proposed method is validated through a numerical study of a simple but representative beam structure. The effect of coordinate incompleteness and robustness of method under presence of noise is investigated. The results of updating obtained by the improved method are compared with the existing response function method. The performance of the two approaches is compared for cases of light, medium and heavily damped structures. It is found that the proposed improved method is effective in updating of mass and stiffness matrices in all the cases of complete and incomplete data and with all levels and types of damping.

SPALLMAP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sabau, Adrian; Wright, Ian

Boiler tubes in steam power plants experience exfoliation of oxide grown on the inner side of the tubes. In extreme cases, the exfoliation cause significant tube blockages that lead to forced power plant outages. It is thus desired to predict through modeling the propensity of exfoliation events in order to inform power plant operators of possible tube blockages. SpallMap solves for the stress-strain equations in an axisymmetric geometry, tracking the stress/strain evolution during boiler operation including outages at one-location along a boiler tube and compares it with scale damage criteria represented by Armitt diagram. The SPALLMAP code contains modules developedmore » for oxide growth, stress analysis, and classical fracture mechanics correlations by taking into account the following phenomena and features, (a) Non-uniform thermal expansion coefficient of oxides and metal substrates, (b) Plant operation schedule with periodic alternate full-load and partial-load regimes, (c) axisymmetric formulation for cylindrical tubes, (d) Multiple oxide layers, (e) oxide-growth induced stresses, and (f) damage criteria from classical fracture mechanics. The computer program is written in FORTRAN90. Its modular structure was sought for allowing the best flexibility in updating the program by implementing new constitutive equations due to availability of new material property data and/or new physical phenomena.« less

Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating

PubMed Central

Rudebeck, Peter H.; Saunders, Richard C.; Prescott, Anna T.; Chau, Lily S.; Murray, Elisabeth A.

2013-01-01

Two ideas have dominated the neuropsychology of the orbitofrontal cortex (OFC). One holds that OFC regulates emotion and enhances behavioral flexibility through inhibitory control. The other ascribes to OFC a role in updating valuations based on current motivational states. Neuroimaging, neurophysiological and clinical observations are consistent with either or both hypotheses. Although these hypotheses are compatible in principle, the present results support the latter view of OFC function and argue against the former. We show that excitotoxic, fibersparing lesions confined to OFC in monkeys do not alter either behavioral flexibility, as measured by object reversal learning, or emotion regulation, as assessed by snake fear. A follow-up experiment indicates that previous reports of a loss of inhibitory control resulted from damage to nearby fiber tracts and not from OFC dysfunction. Thus, OFC plays a more specialized role in reward-guided behavior and emotion than currently thought, a function that includes value updating. PMID:23792944

Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating.

PubMed

Rudebeck, Peter H; Saunders, Richard C; Prescott, Anna T; Chau, Lily S; Murray, Elisabeth A

2013-08-01

Two ideas have dominated neuropsychology concerning the orbitofrontal cortex (OFC). One holds that OFC regulates emotion and enhances behavioral flexibility through inhibitory control. The other ascribes to OFC a role in updating valuations on the basis of current motivational states. Neuroimaging, neurophysiological and clinical observations are consistent with either or both hypotheses. Although these hypotheses are compatible in principle, we present results supporting the latter view of OFC function and arguing against the former. We found that excitotoxic, fiber-sparing lesions confined to OFC in monkeys did not alter either behavioral flexibility, as measured by object reversal learning, or emotion regulation, as assessed by fear of snakes. A follow-up experiment indicated that a previously reported loss of inhibitory control resulted from damage to nearby fiber tracts and not from OFC dysfunction. Thus, OFC has a more specialized role in reward-guided behavior and emotion than has been thought, a function that includes value updating.

First report of the Soybean Cyst Nematode, Heterodera glycines, in New York

USDA-ARS?s Scientific Manuscript database

The soybean cyst nematode (SCN), Heterodera glycines Ichinohe, is the most damaging pathogen of soybean (Glycine max (L.) Merr.), causing more than $1 billion in yield losses annually in the United States (Koenning and Wrather 2010). The SCN distribution map updated in 2014 showed that SCN were dete...

Build Green: Wood Can Last for Centuries

Treesearch

Carol A. Clausen; Samuel V. Glass

2012-01-01

This report updates and revises information from the 1976 Forest Service publication by Rodney C. DeGroot, “Your Wood Can Last for Centuries.” It explains why wood decays, alerts the homeowner to conditions that can result in decay in buildings, and describes measures to prevent moisture-related damage to wood.

CMS MDS 3.0 Section M Skin Conditions in Long-term Care: Pressure Ulcers, Skin Tears, and Moisture-Associated Skin Damage Data Update.

PubMed

Ayello, Elizabeth A

2017-09-01

The purpose of this learning activity is to provide information about the updates to the Centers for Medicare & Medicaid Services (CMS) MDS 3.0 Section M, Skin Conditions documentation in long-term care. This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. After participating in this educational activity, the participant should be better able to:1. Explain the use of the CMS MDS 3.0 tool for documenting skin problems in long-term care.2. Demonstrate examples of proper documentation for specific skin problems. This manuscript reviews some of the key parts of the October 2016 revised Long-term Care Resident Assessment Instrument manual for Minimum Data Set (MDS) 3.0 Section M Skin Conditions. It also reports the Centers for Medicare & Medicaid's publicly reported frequency data in long-term care for selected items on the MDS 3.0 Section M Skin Conditions. Percentages and trends of pressure ulcers/injuries, skin tears, and moisture-associated skin damage are assessed.

Reliability based impact localization in composite panels using Bayesian updating and the Kalman filter

NASA Astrophysics Data System (ADS)

Morse, Llewellyn; Sharif Khodaei, Zahra; Aliabadi, M. H.

2018-01-01

In this work, a reliability based impact detection strategy for a sensorized composite structure is proposed. Impacts are localized using Artificial Neural Networks (ANNs) with recorded guided waves due to impacts used as inputs. To account for variability in the recorded data under operational conditions, Bayesian updating and Kalman filter techniques are applied to improve the reliability of the detection algorithm. The possibility of having one or more faulty sensors is considered, and a decision fusion algorithm based on sub-networks of sensors is proposed to improve the application of the methodology to real structures. A strategy for reliably categorizing impacts into high energy impacts, which are probable to cause damage in the structure (true impacts), and low energy non-damaging impacts (false impacts), has also been proposed to reduce the false alarm rate. The proposed strategy involves employing classification ANNs with different features extracted from captured signals used as inputs. The proposed methodologies are validated by experimental results on a quasi-isotropic composite coupon impacted with a range of impact energies.

Overview, prevention and management of chemotherapy extravasation.

PubMed

Kreidieh, Firas Y; Moukadem, Hiba A; El Saghir, Nagi S

2016-02-10

Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.

Overview, prevention and management of chemotherapy extravasation

PubMed Central

Kreidieh, Firas Y; Moukadem, Hiba A; El Saghir, Nagi S

2016-01-01

Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused. PMID:26862492

Earthquake outlook for the San Francisco Bay region 2014–2043

USGS Publications Warehouse

Aagaard, Brad T.; Blair, James Luke; Boatwright, John; Garcia, Susan H.; Harris, Ruth A.; Michael, Andrew J.; Schwartz, David P.; DiLeo, Jeanne S.; Jacques, Kate; Donlin, Carolyn

2016-06-13

Using information from recent earthquakes, improved mapping of active faults, and a new model for estimating earthquake probabilities, the 2014 Working Group on California Earthquake Probabilities updated the 30-year earthquake forecast for California. They concluded that there is a 72 percent probability (or likelihood) of at least one earthquake of magnitude 6.7 or greater striking somewhere in the San Francisco Bay region before 2043. Earthquakes this large are capable of causing widespread damage; therefore, communities in the region should take simple steps to help reduce injuries, damage, and disruption, as well as accelerate recovery from these earthquakes.

Wooden beverage cases cause little damage to bottle caps

Treesearch

R. Bruce Anderson; William C. Miller

1973-01-01

Wooden beverage cases cause little damage to aluminum resealable caps during distribution. A study at bottling plants and distribution warehouses showed that an average of 1 bottle out of 4,000 has cap damage. Most of the damage was attributed to handling at the warehouse and in transit. Some recommendations are given for improvement of wooden beverage cases to prevent...

32 CFR 750.48 - Measure of damages in injury or death cases.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Measure of damages in injury or death cases. 750... GENERAL CLAIMS REGULATIONS Military Claims Act § 750.48 Measure of damages in injury or death cases. (a... possessions, determine the measure of damages under the law of the location where the injury arises. (b) Where...

32 CFR 750.48 - Measure of damages in injury or death cases.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Measure of damages in injury or death cases. 750... GENERAL CLAIMS REGULATIONS Military Claims Act § 750.48 Measure of damages in injury or death cases. (a... possessions, determine the measure of damages under the law of the location where the injury arises. (b) Where...

32 CFR 750.48 - Measure of damages in injury or death cases.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Measure of damages in injury or death cases. 750... GENERAL CLAIMS REGULATIONS Military Claims Act § 750.48 Measure of damages in injury or death cases. (a... possessions, determine the measure of damages under the law of the location where the injury arises. (b) Where...

32 CFR 750.48 - Measure of damages in injury or death cases.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Measure of damages in injury or death cases. 750... GENERAL CLAIMS REGULATIONS Military Claims Act § 750.48 Measure of damages in injury or death cases. (a... possessions, determine the measure of damages under the law of the location where the injury arises. (b) Where...

32 CFR 750.48 - Measure of damages in injury or death cases.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Measure of damages in injury or death cases. 750... GENERAL CLAIMS REGULATIONS Military Claims Act § 750.48 Measure of damages in injury or death cases. (a... possessions, determine the measure of damages under the law of the location where the injury arises. (b) Where...

A Meteorological Model's Dependence on Radiation Update Frequency

NASA Technical Reports Server (NTRS)

Eastman, Joseph L.; Peters-Lidard, Christa; Tao, Wei-Kuo; Kumar, Sujay; Tian, Yudong; Lang, Stephen E.; Zeng, Xiping

2004-01-01

Numerical weather models are used to simulate circulations in the atmosphere including clouds and precipitation by applying a set of mathematical equations over a three-dimensional grid. The grid is composed of discrete points at which the meteorological variables are defined. As computing power continues to rise these models are being used at finer grid spacing, but they must still cover a wide range of scales. Some of the physics that must be accounted for in the model cannot be explicitly resolved, and their effects, therefore, must be estimated or "parameterized". Some of these parameterizations are computationally expensive. To alleviate the problem, they are not always updated at the time resolution of the model with the assumption being that the impact will be small. In this study, a coupled land-atmosphere model is used to assess the impact of less frequent updates of the computationally expensive radiation physics for a case on June 6, 2002, that occurred during a field experiment over the central plains known as International H20 Project (IHOP). The model was tested using both the original conditions, which were dry, and with modified conditions wherein moisture was added to the lower part of the atmosphere to produce clouds and precipitation (i.e., a wet case). For each of the conditions (i.e., dry and wet), four set of experiments were conducted wherein the model was run for a period of 24 hours and the radiation fields (including both incoming solar and outgoing longwave) were updated every 1, 3, 10, and 100 time steps. Statistical tests indicated that average quantities of surface variables for both the dry and wet cases were the same for the various update frequencies. However, spatially the results could be quite different especially in the wet case after it began to rain. The near-surface wind field was found to be different most of the time even for the dry case. In the wet case, rain intensities and average vertical profiles of heating associated with cloudy areas were found to differ for the various radiation update frequencies. The latter implies that the mean state of the model could be different as a result of not updating the radiation fields every time step and has important implications for longer term climate studies

Air traffic control surveillance accuracy and update rate study

NASA Technical Reports Server (NTRS)

Craigie, J. H.; Morrison, D. D.; Zipper, I.

1973-01-01

The results of an air traffic control surveillance accuracy and update rate study are presented. The objective of the study was to establish quantitative relationships between the surveillance accuracies, update rates, and the communication load associated with the tactical control of aircraft for conflict resolution. The relationships are established for typical types of aircraft, phases of flight, and types of airspace. Specific cases are analyzed to determine the surveillance accuracies and update rates required to prevent two aircraft from approaching each other too closely.

Evaluation of Teachers and Leaders. State Implementation of College- and Career-Readiness Standards

ERIC Educational Resources Information Center

Anderson, Kimberly; Mira, Mary Elizabeth

2015-01-01

By 2012, all of the states in this study had started implementing new or revised teacher and leader evaluation systems. The systems include many and varying updates. In some cases, the updates were designed to meet conditions for a state's "Race to the Top" grant. In others, the updates were made to meet conditions for a state's waiver…

Schools Going Solar: A Guide to Schools Enjoying the Power of Solar Energy. Volume 2.

ERIC Educational Resources Information Center

Hitchcock, Susan Tyler

This companion document updates an April 1998 volume on designing schools to use solar energy as a power source. Volume 2 presents numerous case studies of solar installations in new and existing schools across the United States and Europe, updates and presents new examples of solar education programs, and offers an updated resource listing of…

Evolving learning rules and emergence of cooperation in spatial prisoner's dilemma.

PubMed

Moyano, Luis G; Sánchez, Angel

2009-07-07

In the evolutionary Prisoner's dilemma (PD) game, agents play with each other and update their strategies in every generation according to some microscopic dynamical rule. In its spatial version, agents do not play with every other but, instead, interact only with their neighbours, thus mimicking the existing of a social or contact network that defines who interacts with whom. In this work, we explore evolutionary, spatial PD systems consisting of two types of agents, each with a certain update (reproduction, learning) rule. We investigate two different scenarios: in the first case, update rules remain fixed for the entire evolution of the system; in the second case, agents update both strategy and update rule in every generation. We show that in a well-mixed population the evolutionary outcome is always full defection. We subsequently focus on two-strategy competition with nearest-neighbour interactions on the contact network and synchronised update of strategies. Our results show that, for an important range of the parameters of the game, the final state of the system is largely different from that arising from the usual setup of a single, fixed dynamical rule. Furthermore, the results are also very different if update rules are fixed or evolve with the strategies. In these respect, we have studied representative update rules, finding that some of them may become extinct while others prevail. We describe the new and rich variety of final outcomes that arise from this co-evolutionary dynamics. We include examples of other neighbourhoods and asynchronous updating that confirm the robustness of our conclusions. Our results pave the way to an evolutionary rationale for modelling social interactions through game theory with a preferred set of update rules.

USDA-ARS Knipling-Bushland U.S. Livestock Insects Research Laboratory Tick & Biting Fly Research Unit scientific update

USDA-ARS?s Scientific Manuscript database

Ticks and biting flies cause tremendous economic damage to the U.S. livestock industry while also being a health concern to humans. Research on their biology and control is done at the Knipling-Bushland U.S. Livestock Insects Research Laboratory, Tick and Biting Fly Research Unit with scientists loc...

An Innovative Approach to Improve Completeness of Treatment and Other Key Data Elements in a Population-Based Cancer Registry: A15-Month Data Submission.

PubMed

Hsieh, Mei-Chin; Mumphrey, Brent; Pareti, Lisa; Yi, Yong; Wu, Xiao-Cheng

2017-01-01

BACKGROUND: In order to comply with the Louisiana legislative obligation and meet funding agencies’ requirement of case completeness for 12-month data submission, hospital cancer registries are mandated to submit cancer incidence data to the Louisiana Tumor Registry (LTR) within 6 months of diagnosis. However, enforcing compliance with timely reporting may result in incomplete data on adjuvant treatment received by the LTR. Although additional treatment information can be obtained via retransmission of the North American Association of Central Cancer Registries (NAACCR)–modified abstracts, consolidating multiple NAACCR-modified abstracts for the same case is extremely time consuming. To avoid a huge amount of work while obtaining timely and complete data, the LTR has requested hospital cancer registries resubmit their data 15 months after the close of the diagnosis year. The purpose of this report is to assess the improvement in the completeness of data items related to treatment, staging and site specific factors. METHODS: The LTR requested that hospital cancer registries resubmit 15-month data between April 1, 2016 and April 15, 2016 for cases diagnosed in 2014. Microsoft Visual Studio Visual Basic script was used to link and compare resubmitted data with existing data in the LTR database. Data elements used for matching same patient/tumor were name, Social Security number, date of birth, primary site, laterality, and hospital identifier number. Treatment data items were compared as known vs none/ unknown and known vs known with different code. Matched records with updated information were imported into the LTR database and flagged as modified abstract records for manual consolidation. Nonmatched records were also loaded in the LTR database as potential new cases for further investigation. RESULTS: A total of 25,207 resubmitted NAACCR abstracts were received from 38 hospitals and freestanding radiation centers. About 11.1% had at least 1 update related to treatment and/or other data item; an average of 3.3 updates per updated abstract. The majority of the updates (45.7%) for treatment were changes from none/unknown to known value and 42.6% of the updates were related to radiation treatment fields. In addition, 172 potential new cases were identified. Approximately 10.5% (18 cases) of these new cases were confirmed to be truly missed cases after investigation. CONCLUSION: The 15-month data resubmission is a cost-effective approach to obtaining complete information on treatment and other key data items from reporting facilities and can also be used to identify potential missed cases.

A new version of the ERICA tool to facilitate impact assessments of radioactivity on wild plants and animals.

PubMed

Brown, J E; Alfonso, B; Avila, R; Beresford, N A; Copplestone, D; Hosseini, A

2016-03-01

A new version of the ERICA Tool (version 1.2) was released in November 2014; this constitutes the first major update of the Tool since release in 2007. The key features of the update are presented in this article. Of particular note are new transfer databases extracted from an international compilation of concentration ratios (CRwo-media) and the modification of 'extrapolation' approaches used to select transfer data in cases where information is not available. Bayesian updating approaches have been used in some cases to draw on relevant information that would otherwise have been excluded in the process of deriving CRwo-media statistics. All of these efforts have in turn led to the requirement to update Environmental Media Concentration Limits (EMCLs) used in Tier 1 assessments. Some of the significant changes with regard to EMCLs are highlighted. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Damage-mitigating control of aerospace systems for high performance and extended life

NASA Technical Reports Server (NTRS)

Ray, Asok; Wu, Min-Kuang; Carpino, Marc; Lorenzo, Carl F.; Merrill, Walter C.

1992-01-01

The concept of damage-mitigating control is to minimize fatigue (as well as creep and corrosion) damage of critical components of mechanical structures while simultaneously maximizing the system dynamic performance. Given a dynamic model of the plant and the specifications for performance and stability robustness, the task is to synthesize a control law that would meet the system requirements and, at the same time, satisfy the constraints that are imposed by the material and structural properties of the critical components. The authors present the concept of damage-mitigating control systems design with the following objectives: (1) to achieve high performance with a prolonged life span; and (2) to systematically update the controller as the new technology of advanced materials evolves. The major challenge is to extract the information from the material properties and then utilize this information in a mathematical form so that it can be directly applied to robust control synthesis for mechanical systems. The basic concept of damage-mitigating control is illustrated using a relatively simplified model of a space shuttle main engine.

Finite element implementation of a thermo-damage-viscoelastic constitutive model for hydroxyl-terminated polybutadiene composite propellant

NASA Astrophysics Data System (ADS)

Xu, Jinsheng; Han, Long; Zheng, Jian; Chen, Xiong; Zhou, Changsheng

2017-11-01

A thermo-damage-viscoelastic model for hydroxyl-terminated polybutadiene (HTPB) composite propellant with consideration for the effect of temperature was implemented in ABAQUS. The damage evolution law of the model has the same form as the crack growth equation for viscoelastic materials, and only a single damage variable S is considered. The HTPB propellant was considered as an isotropic material, and the deviatoric and volumetric strain-stress relations are decoupled and described by the bulk and shear relaxation moduli, respectively. The stress update equations were expressed by the principal stresses σ_{ii}R and the rotation tensor M, the Jacobian matrix in the global coordinate system J_{ijkl} was obtained according to the fourth-order tensor transformation rules. Two models having complex stress states were used to verify the accuracy of the constitutive model. The test results showed good agreement with the strain responses of characteristic points measured by a contactless optical deformation test system, which illustrates that the thermo-damage-viscoelastic model perform well at describing the mechanical properties of an HTPB propellant.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Four years after its occurrence rocked the petroleum industry and revitalized the US environmental movement, the Exxon Valdez tanker oil spill off Alaska continues to stir controversy. Conflicting reports abound over whether there is long term damage to the Prince William Sound ecosystem resulting from the March 24, 1989, spill. Government scientists at recent conferences disclosed studies they contend show long term, significant damage to the sound. Exxon this month launched a counteroffensive, disclosing results of studies it funded that it claims show no credible scientific evidence of long term damage. At the same time, the company blasted as flawedmore » the government's data on assessing environmental damage to the sound and charged that test samples from the sound were mishandled. Meantime, Prince William Sound still shows lingering effects from the Exxon Valdez oil spill. But recovery has been so rapid that there is more controversy over how to use $900 million in natural resource recovery funds that Exxon paid than over how badly species are suffering. The paper describes Exxon's studies; faulty data; lingering damage; and an update on tanker safety.« less

Michoud Recovering From Tornado on This Week @NASA – February 10, 2017

NASA Image and Video Library

2017-02-10

Recovery efforts are underway at NASA’s Michoud Assembly Facility in New Orleans, which was hit by a tornado Feb. 7. In accounting for all 3,500 employees at the facility, officials reported five suffered minor injuries. Buildings, structures and parked cars sustained damage, but there was no reported damage to hardware for NASA’s Space Launch System (SLS) rocket, Orion spacecraft, or the barge Pegasus docked at Michoud. NASA will release updates on the facility’s status as they become available. Also, SpaceX Launch Targeted for Mid-February, SLS Booster Hardware Arrives at KSC, and NASA Aerospace Days!

Development of GENOA Progressive Failure Parallel Processing Software Systems

NASA Technical Reports Server (NTRS)

Abdi, Frank; Minnetyan, Levon

1999-01-01

A capability consisting of software development and experimental techniques has been developed and is described. The capability is integrated into GENOA-PFA to model polymer matrix composite (PMC) structures. The capability considers the physics and mechanics of composite materials and structure by integration of a hierarchical multilevel macro-scale (lamina, laminate, and structure) and micro scale (fiber, matrix, and interface) simulation analyses. The modeling involves (1) ply layering methodology utilizing FEM elements with through-the-thickness representation, (2) simulation of effects of material defects and conditions (e.g., voids, fiber waviness, and residual stress) on global static and cyclic fatigue strengths, (3) including material nonlinearities (by updating properties periodically) and geometrical nonlinearities (by Lagrangian updating), (4) simulating crack initiation. and growth to failure under static, cyclic, creep, and impact loads. (5) progressive fracture analysis to determine durability and damage tolerance. (6) identifying the percent contribution of various possible composite failure modes involved in critical damage events. and (7) determining sensitivities of failure modes to design parameters (e.g., fiber volume fraction, ply thickness, fiber orientation. and adhesive-bond thickness). GENOA-PFA progressive failure analysis is now ready for use to investigate the effects on structural responses to PMC material degradation from damage induced by static, cyclic (fatigue). creep, and impact loading in 2D/3D PMC structures subjected to hygrothermal environments. Its use will significantly facilitate targeting design parameter changes that will be most effective in reducing the probability of a given failure mode occurring.

Tracking composite material damage evolution using Bayesian filtering and flash thermography data

NASA Astrophysics Data System (ADS)

Gregory, Elizabeth D.; Holland, Steve D.

2016-05-01

We propose a method for tracking the condition of a composite part using Bayesian filtering of ash thermography data over the lifetime of the part. In this demonstration, composite panels were fabricated; impacted to induce subsurface delaminations; and loaded in compression over multiple time steps, causing the delaminations to grow in size. Flash thermography data was collected between each damage event to serve as a time history of the part. The ash thermography indicated some areas of damage but provided little additional information as to the exact nature or depth of the damage. Computed tomography (CT) data was also collected after each damage event and provided a high resolution volume model of damage that acted as truth. After each cycle, the condition estimate, from the ash thermography data and the Bayesian filter, was compared to 'ground truth'. The Bayesian process builds on the lifetime history of ash thermography scans and can give better estimates of material condition as compared to the most recent scan alone, which is common practice in the aerospace industry. Bayesian inference provides probabilistic estimates of damage condition that are updated as each new set of data becomes available. The method was tested on simulated data and then on an experimental data set.

FIRE-CAT - An application for mobile devices for first response after natural disasters

NASA Astrophysics Data System (ADS)

Eggert, S.; Schmid, S.

2011-12-01

The FIRE-CAT application uses the technology of an easy to use mobile application that works independently from any phone system and applies it to the field of near real-time disaster management. The application allows the user to report about structural or human damages to the operation's head quarter. Requirements are a mobile phone or tablet based on the WebOS system and equipped with a GPS receiver. Starting the application, the user can tag a damage to the actual position he is. He can distinguish between different classes of damage, from "visually intact building" to "completely collapsed building" and add any further information concerning human losses or comments. This information will then be sent to a geographical information system in the head quarter. Information can also be updated, corrected or completed with comments. The damage map created by these reports from victims directly in the affected areas can then be a base for the disaster management to decide where to send rescue teams first.

Uncertainty aggregation and reduction in structure-material performance prediction

NASA Astrophysics Data System (ADS)

Hu, Zhen; Mahadevan, Sankaran; Ao, Dan

2018-02-01

An uncertainty aggregation and reduction framework is presented for structure-material performance prediction. Different types of uncertainty sources, structural analysis model, and material performance prediction model are connected through a Bayesian network for systematic uncertainty aggregation analysis. To reduce the uncertainty in the computational structure-material performance prediction model, Bayesian updating using experimental observation data is investigated based on the Bayesian network. It is observed that the Bayesian updating results will have large error if the model cannot accurately represent the actual physics, and that this error will be propagated to the predicted performance distribution. To address this issue, this paper proposes a novel uncertainty reduction method by integrating Bayesian calibration with model validation adaptively. The observation domain of the quantity of interest is first discretized into multiple segments. An adaptive algorithm is then developed to perform model validation and Bayesian updating over these observation segments sequentially. Only information from observation segments where the model prediction is highly reliable is used for Bayesian updating; this is found to increase the effectiveness and efficiency of uncertainty reduction. A composite rotorcraft hub component fatigue life prediction model, which combines a finite element structural analysis model and a material damage model, is used to demonstrate the proposed method.

Emerald ash borer in Russia: 2009 situation update

Treesearch

Y. Baranchikov; Y. Gninenko; G. Yurchenko

2011-01-01

The emerald ash borer (EAB), Agrilus planipennis Fairmaire, is a beetle native to East Asia and the Russian Far East where it is considered a minor pest, attacking weakened or dying ash trees. In 2006, EAB was found to be responsible for enormous damage of ash species in Moscow, which causes serious concern for Europe. Recently we reviewed the EAB...

Rock falls landslides in Abruzzo (Central Italy) after recent earthquakes: morphostructural control

NASA Astrophysics Data System (ADS)

Piacentini, T.; Miccadei, E.; Di Michele, R.; Esposito, G.

2012-04-01

Recent earthquakes show that damages due to collateral effects could, in some cases exceed the economic and social losses directly connected to the seismic shaking. The earthquake heavily damaged urban areas and villages and induced several coseismic deformations and geomorphologic effects, including different types of instability such as: rock falls, debris falls, sink holes, ground collapses, liquefaction, etc. Among the effects induced by the seismic energy release, landslides are one of the most significant in terms of hazard and related risk, owing to the occurrence of exposed elements. This work analyzes the geomorphological effects, and particularly the rock falls, which occurred in the L'Aquila area during and immediately after the April 2009 earthquake. The analysis is focused mainly on the rock fall distribution related to the local morphostructural setting. Rock falls occurred mostly on calcareous bedrock slopes or on scarps developed on conglomerates and breccias of Quaternary continental deposits. Geological and geomorphological surveys have outlined different types of rock falls on different morpho-structural settings, which can be summarized as follow: 1)rock falls on calcareous faulted homoclinal ridges; 2)rock falls on calcareous rock slopes of karst landforms; 3)rock falls on structural scarps on conglomerates and breccias of Quaternary continental deposits. The first type of rockfall occurred particularly along main gorges carved on calcareous rocks and characterised by very steep fault slopes and structural slopes (i.e. San Venanzio Gorges, along the Aterno river). In these cases already unstable slopes due to lithological and structural control were triggered as rockfalls also at high distance from the epicentre area. These elements provide useful indications both at local scale, for seismic microzonation studies and seismic risk prevention, and at regional scale, for updating studies and inventory of landslides.

Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning.

PubMed

Ekino, Shigeo; Susa, Mari; Ninomiya, Tadashi; Imamura, Keiko; Kitamura, Toshinori

2007-11-15

The first well-documented outbreak of acute methyl mercury (MeHg) poisoning by consumption of contaminated fish occurred in Minamata, Japan, in 1953. The clinical picture was officially recognized and called Minamata disease (MD) in 1956. However, 50 years later there are still arguments about the definition of MD in terms of clinical symptoms and extent of lesions. We provide a historical review of this epidemic and an update of the problem of MeHg toxicity. Since MeHg dispersed from Minamata to the Shiranui Sea, residents living around the sea were exposed to low-dose MeHg through fish consumption for about 20 years (at least from 1950 to 1968). These patients with chronic MeHg poisoning continue to complain of distal paresthesias of the extremities and the lips even 30 years after cessation of exposure to MeHg. Based on findings in these patients the symptoms and lesions in MeHg poisoning are reappraised. The persisting somatosensory disorders after discontinuation of exposure to MeHg were induced by diffuse damage to the somatosensory cortex, but not by damage to the peripheral nervous system, as previously believed.

Carcinogenicity of chromium and chemoprevention: a brief update

PubMed Central

Gu, Yuanliang; Song, Xin; Zhao, Jinshun

2017-01-01

Chromium has two main valence states: hexavalent chromium (Cr[VI]) and trivalent chromium (Cr[III]). Cr(VI), a well-established human carcinogen, can enter cells by way of a sulfate/phosphate anion-transport system, and then be reduced to lower-valence intermediates consisting of pentavalent chromium (Cr[V]), tetravalent chromium (Cr[IV]) or Cr(III) via cellular reductants. These intermediates may directly or indirectly result in DNA damage or DNA–protein cross-links. Although Cr(III) complexes cannot pass easily through cell membranes, they have the ability to accumulate around cells to induce cell-surface morphological alteration and result in cell-membrane lipid injuries via disruption of cellular functions and integrity, and finally to cause DNA damage. In recent years, more research, including in vitro, in vivo, and epidemiological studies, has been conducted to evaluate the genotoxicity/carcinogenicity induced by Cr(VI) and/or Cr(III) compounds. At the same time, various therapeutic agents, especially antioxidants, have been explored through in vitro and in vivo studies for preventing chromium-induced genotoxicity/carcinogenesis. This review aims to provide a brief update on the carcinogenicity of Cr(VI) and Cr(III) and chemoprevention with different antioxidants. PMID:28860815

Biological and chemical weapons of mass destruction: updated clinical therapeutic countermeasures since 2003.

PubMed

Pettineo, Christopher; Aitchison, Robert; Leikin, Scott M; Vogel, Stephen N; Leikin, Jerrold B

2009-01-01

The objective of this article is to provide updated treatment options for bioterrorism agents. This updated synopsis includes recent clinical cases and treatment recommendations that have arisen in the last 5 years. The decontamination, treatment, and disposition of these biologic and chemical agents are presented alphabetically by agent type: biologic, chemical, and radiologic/nuclear. The information provided outlines only new treatment options since 2003.

An Investigation Into the Effects of Frequency Response Function Estimators on Model Updating

NASA Astrophysics Data System (ADS)

Ratcliffe, M. J.; Lieven, N. A. J.

1999-03-01

Model updating is a very active research field, in which significant effort has been invested in recent years. Model updating methodologies are invariably successful when used on noise-free simulated data, but tend to be unpredictable when presented with real experimental data that are—unavoidably—corrupted with uncorrelated noise content. In the development and validation of model-updating strategies, a random zero-mean Gaussian variable is added to simulated test data to tax the updating routines more fully. This paper proposes a more sophisticated model for experimental measurement noise, and this is used in conjunction with several different frequency response function estimators, from the classical H1and H2to more refined estimators that purport to be unbiased. Finite-element model case studies, in conjunction with a genuine experimental test, suggest that the proposed noise model is a more realistic representation of experimental noise phenomena. The choice of estimator is shown to have a significant influence on the viability of the FRF sensitivity method. These test cases find that the use of the H2estimator for model updating purposes is contraindicated, and that there is no advantage to be gained by using the sophisticated estimators over the classical H1estimator.

The approaches for the decision support in case natural hazards

NASA Astrophysics Data System (ADS)

Vyazilov, Evgeny; Chunyaev, Nikita

2013-04-01

In spite of using highly automated systems of measurement, collecting, storing, handling, prediction and delivery of information on the marine environment, including natural hazards, the amount of damage from natural phenomena increases. Because information on the marine environment delivered to the industrial facilities not effectively used. To such information pays little attention by individual decision-makers and not always perform preventive measures necessary for reduce and prevent damage. Automation of information support will improve the efficiency management of the marine activities. In Russia develops "The Unified system of the information about World ocean" (ESIMO, http://esimo.ru/), that integrates observation, analysis, prognostic and climate data. Necessary to create tools to automatic selection natural disasters through all integrated data; notification decision-makers about arising natural hazards - software agent; provision of information in a compact form for the decision-makers; assessment of possible damage and costs to the preventive measures; providing information on the impacts of environment on economic facilities and recommendations for decision-making; the use of maps, diagrams, tables for reporting. Tools for automatic selection designed for identification of natural phenomena based on the resources ESIMO and corresponding critical values of the indicators environment. The result of this module will be constantly updated database of critical situations of environment for each object or technological process. To operational notify and provide current information about natural hazards proposes using a software agent that is installed on the computer decision-makers, which is activated in case critical situations and provides a minimum of information. In the event of natural disaster software agent should be able to inform decision-makers about this, providing information on the current situation, and the possibility for more and detailed information about natural hazard. Software agent must be able to be configured by the user to a specific object: a specific station or a drilling rigs that region or area, regardless of the size of the object. And depending on the selected settings and parameters it needs to apply the values of critical indexes. There is a need for real-time display hydrometeorological information with compact scheme that reflects the environment indicators that affect industrial facility in the form of devices (thermometer, aneroid, footstock, speedometer, hygrometer, thermograph, barograph, rain gauge, wind vane, etc.) with the ability to display indicators exceed a critical value. This scheme is designed to provide maximum information in the shortest possible time reference that provides an intuitive interface (display by generally accepted standardized instruments). Analytical services ESIMO combined with geographic information service provides information about area or point to decision-makers of showing the dynamics of changes of parameters in the form of graphics, diagrams, maps, tables. If the data sources are updated, analytical services automatically provides the relevance of the data in the analytical views of the complex. Analytical services works with database of integrated data and used for the preparation and presentation of the consumers of the federal and regional level for the analysis of information on the World Oceans. The analytic services show a set of indicators about the situation in the World Ocean. The complex provides the processing, analysis of qualitative and quantitative characteristics (indexes) of the marine environment and maritime activities of the Russian Federation. To assess the need for preventive measures, decision-makers require information in the form of potential economic consequences of natural hazard, cost of preventive measures to prevent damage. We can use for that the economic and mathematical models. When making the decision decision-makers must understand the possible consequences of natural phenomena and rely on the advice that they receive from a decision support system. Such information about the impacts and recommendations are based on the knowledge base (rules of "if, then"), formed on the basis of experience gained in the past. This should take into account not only the critical values for each object and technological process, but also the type of information (observations, forecasting, climate, and after the phenomenon), the level of decision-making, the season of the year, the climate zone where the object is located. Within ESIMO created integrated database that containing the results of the monitoring of the marine environment. The database includes the observation, analysis, and forecasting and climate data. Operational data is updated automatically at specified intervals of a few minutes to a week, depending on the frequency of observations. Climatic data is updated as needed, for example, once a year or once every five years. Integrated database contains a set of indicators related to a specific object, and to a certain geographic area, according to the observations made and the data entered data. In addition to hydrometeorological parameters database contains socio-economic information. At present, was created the database of critical values and information about the impacts of and recommendations for the 30 natural hazards, developed the data structure and software is under development. The interaction of all components of an information support will reduce the economic damage from natural disaster on individual objects economy (ships, ports, etc.) and improve public safety through more prompt delivery of information to decision-makers and the public, besides receive more informative data (district with symptoms natural phenomena , assessment of possible damage, the impact of and recommendations).

Ohio River main stem study - The role of geographic information systems and remote sensing in flood damage assessments

NASA Technical Reports Server (NTRS)

Edwardo, H. A.; Moulis, F. R.; Merry, C. J.; Mckim, H. L.; Kerber, A. G.; Miller, M. A.

1985-01-01

The Pittsburgh District, Corps of Engineers, has conducted feasibility analyses of various procedures for performing flood damage assessments along the main stem of the Ohio River. Procedures using traditional, although highly automated, techniques and those based on geographic information systems have been evaluated at a test site, the City of New Martinsville, Wetzel County, WV. The flood damage assessments of the test site developed from an automated, conventional structure-by-structure appraisal served as the ground truth data set. A geographic information system was developed for the test site which includes data on hydraulic reach, ground and reference flood elevations, and land use/cover. Damage assessments were made using land use mapping developed from an exhaustive field inspection of each tax parcel. This ground truth condition was considered to provide the best comparison of flood damages to the conventional approach. Also, four land use/cover data sets were developed from Thematic Mapper Simulator (TMS) and Landsat-4 Thematic Mapper (TM) data. One of these was also used to develop a damage assessment of the test site. This paper presents the comparative absolute and relative accuracies of land use/cover mapping and flood damage assessments, and the recommended role of geographic information systems aided by remote sensing for conducting flood damage assessments and updates along the main stem of the Ohio River.

Updating the Behavior Engineering Model.

ERIC Educational Resources Information Center

Chevalier, Roger

2003-01-01

Considers Thomas Gilbert's Behavior Engineering Model as a tool for systematically identifying barriers to individual and organizational performance. Includes a detailed case study and a performance aid that incorporates gap analysis, cause analysis, and force field analysis to update the original model. (Author/LRW)

Repairing casing at a gas storage field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollenbaugh, B.

1992-09-01

This paper reports on the Leyden gas storage field which is a 1.5-Bcf working volume underground gas storage facility locating at the northwest edge of the Denver, Colo., metropolitan area. The field is owned by Public Service Co. of Colorado and operated by its wholly owned subsidiary, Western Gas Supply Co. Logging technology was instrumental in locating casing damage at two wells, identifying the extent of the damage and ensuring a successful repair. The well casings were repaired by installing a liner between two packers, with one packer set above the damage and the other set below it. Special equipmentmore » and procedures were required for workover and drilling operations because of the complications associated with cavern storage. Logging technology can locate damaged casing and evaluate the type and extent of the damage, and also predict the probability of gas migration behind the casing.« less

Planning practice in support of economically and environmentally sustainable roads in floodplains: the case of the Mekong delta floodplains.

PubMed

Douven, Wim; Buurman, Joost

2013-10-15

Road development in relatively undisturbed floodplain systems, such as the floodplains of the Mekong River, will impact hydraulics and interrupt the natural flow of water. This affects the ecology and environment, and the livelihoods of people who depend on fishing and agriculture. On the other hand, floods can severely damage road infrastructure in years with large floods and can cause high annual maintenance costs. Improving road development practices in floodplains is a complex, multidimensional task involving hydraulic and geotechnical analysis, ecosystem analysis, socio-economic analysis, policy analysis, etc. This paper analyses the planning practice of road development and rehabilitation and how this practice can be improved in support of economically and environmentally sustainable roads in floodplains. It is concluded that although ample technical, planning and environmental assessment guidelines exist, guidelines need updating to address cumulative impacts at floodplain level and factors hampering the implementation in guidelines should be addressed in the guideline design (process). Copyright © 2013 Elsevier Ltd. All rights reserved.

Effectiveness of radio waves application in modern general dental procedures: An update.

PubMed

Qureshi, Arslan; Kellesarian, Sergio Varela; Pikos, Michael A; Javed, Fawad; Romanos, Georgios E

2017-01-01

The purpose of the present study was to review indexed literature and provide an update on the effectiveness of high-frequency radio waves (HRW) application in modern general dentistry procedures. Indexed databases were searched to identify articles that assessed the efficacy of radio waves in dental procedures. Radiosurgery is a refined form of electrosurgery that uses waves of electrons at a radiofrequency ranging between 2 and 4 MHz. Radio waves have also been reported to cause much less thermal damage to peripheral tissues compared with electrosurgery or carbon dioxide laser-assisted surgery. Formation of reparative dentin in direct pulp capping procedures is also significantly higher when HRW are used to achieve hemostasis in teeth with minimally exposed dental pulps compared with traditional techniques for achieving hemostasis. A few case reports have reported that radiosurgery is useful for procedures such as gingivectomy and gingivoplasty, stage-two surgery for implant exposure, operculectomy, oral biopsy, and frenectomy. Radiosurgery is a relatively modern therapeutic methodology for the treatment of trigeminal neuralgia; however, its long-term efficacy is unclear. Radio waves can also be used for periodontal procedures, such as gingivectomies, coronal flap advancement, harvesting palatal grafts for periodontal soft tissue grafting, and crown lengthening. Although there are a limited number of studies in indexed literature regarding the efficacy of radio waves in modern dentistry, the available evidence shows that use of radio waves is a modernization in clinical dentistry that might be a contemporary substitute for traditional clinical dental procedures.

Updating Risk Prediction Tools: A Case Study in Prostate Cancer

PubMed Central

Ankerst, Donna P.; Koniarski, Tim; Liang, Yuanyuan; Leach, Robin J.; Feng, Ziding; Sanda, Martin G.; Partin, Alan W.; Chan, Daniel W; Kagan, Jacob; Sokoll, Lori; Wei, John T; Thompson, Ian M.

2013-01-01

Online risk prediction tools for common cancers are now easily accessible and widely used by patients and doctors for informed decision-making concerning screening and diagnosis. A practical problem is as cancer research moves forward and new biomarkers and risk factors are discovered, there is a need to update the risk algorithms to include them. Typically the new markers and risk factors cannot be retrospectively measured on the same study participants used to develop the original prediction tool, necessitating the merging of a separate study of different participants, which may be much smaller in sample size and of a different design. Validation of the updated tool on a third independent data set is warranted before the updated tool can go online. This article reports on the application of Bayes rule for updating risk prediction tools to include a set of biomarkers measured in an external study to the original study used to develop the risk prediction tool. The procedure is illustrated in the context of updating the online Prostate Cancer Prevention Trial Risk Calculator to incorporate the new markers %freePSA and [−2]proPSA measured on an external case control study performed in Texas, U.S.. Recent state-of-the art methods in validation of risk prediction tools and evaluation of the improvement of updated to original tools are implemented using an external validation set provided by the U.S. Early Detection Research Network. PMID:22095849

Updating risk prediction tools: a case study in prostate cancer.

PubMed

Ankerst, Donna P; Koniarski, Tim; Liang, Yuanyuan; Leach, Robin J; Feng, Ziding; Sanda, Martin G; Partin, Alan W; Chan, Daniel W; Kagan, Jacob; Sokoll, Lori; Wei, John T; Thompson, Ian M

2012-01-01

Online risk prediction tools for common cancers are now easily accessible and widely used by patients and doctors for informed decision-making concerning screening and diagnosis. A practical problem is as cancer research moves forward and new biomarkers and risk factors are discovered, there is a need to update the risk algorithms to include them. Typically, the new markers and risk factors cannot be retrospectively measured on the same study participants used to develop the original prediction tool, necessitating the merging of a separate study of different participants, which may be much smaller in sample size and of a different design. Validation of the updated tool on a third independent data set is warranted before the updated tool can go online. This article reports on the application of Bayes rule for updating risk prediction tools to include a set of biomarkers measured in an external study to the original study used to develop the risk prediction tool. The procedure is illustrated in the context of updating the online Prostate Cancer Prevention Trial Risk Calculator to incorporate the new markers %freePSA and [-2]proPSA measured on an external case-control study performed in Texas, U.S.. Recent state-of-the art methods in validation of risk prediction tools and evaluation of the improvement of updated to original tools are implemented using an external validation set provided by the U.S. Early Detection Research Network. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Epidural mass due to aspergillus flavus causing spinal cord compression--a case report and brief update.

PubMed

Tendolkar, U; Sharma, A; Mathur, M; Ranadive, N; Sachdev, M

2005-07-01

Aspergillus infection of the central nervous system (CNS) is an uncommon disease. Most of the reported cases are of sinocranial spread and cases with contiguous spread to spinal cord from lung and other organs are uncommon. A case of pulmonary aspergillosis with extension to thoracic vertebrae forming a paraspinal mass resulting in neurological deficit due to Aspergillus flavus, is reported. The 43 year old patient did not have any obvious predisposing condition. He presented with loss of motor function and succumbed to the infection despite operative intervention and antifungal therapy. A brief update on CNS aspergillosis is presented along with detailed clinical, radiological and laboratory work up of the patient.

Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judkoff, R.; Neymark, J.

2013-07-01

ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and themore » informative example results.« less

Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judkoff, R.; Neymark, J.

2013-07-01

ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and themore » informative example results.« less

A systematic approach to synoptic tornado climatology of Hungary for the recent years (1996 2001) based on official damage reports

NASA Astrophysics Data System (ADS)

Szilárd, Sárközi

2007-02-01

Due to the significant amount of severe storm damage from the mid 1990s, a practical need has arisen for updating risk assessment. For reliable and systematic sampling of events, data acquisition has been arranged through the disaster management official body using a pyramidal national coverage. Post-analysis, including its meteorological part, proceeds in a GIS environment. This paper focuses specifically on damaging tornadoes, since those are the most violent and best-documented phenomena. Different statistics are calculated and explained, such as seasonal, diurnal and magnitude distributions. Spatial occurrence and features are mapped. A complete synoptic climatology is given by typifying the generating conditions and categorizing events into certain classes, while discussing the role of the Carpathian Basin. In the end a conceptual issue in connection with self-similarity is raised for further discussion.

Pericyte function in the physiological central nervous system.

PubMed

Muramatsu, Rieko; Yamashita, Toshihide

2014-01-01

Damage to the central nervous system (CNS) leads to disruption of the vascular network, causing vascular dysfunction. Vascular dysfunction is the major event in the pathogenesis of CNS diseases and is closely associated with the severity of neuronal dysfunction. The suppression of vascular dysfunction has been considered a promising avenue to limit damage to the CNS, leading to efforts to clarify the cellular and molecular basis of vascular homeostasis maintenance. A reduction of trophic support and oxygen delivery due to circulatory insufficiency has long been regarded as a major cause of vascular damage. Moreover, recent studies provide a new perspective on the importance of the structural stability of blood vessels in CNS diseases. This updated article discusses emerging information on the key role of vascular integrity in CNS diseases, specially focusing on pericyte function. Copyright © 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Nonlinear dynamics and health monitoring of 6-DOF breathing cracked Jeffcott rotor

NASA Astrophysics Data System (ADS)

Zhao, Jie; DeSmidt, Hans; Yao, Wei

2015-04-01

Jeffcott rotor is employed to study the nonlinear vibration characteristics of breathing cracked rotor system and explore the possibility of further damage identification. This paper is an extension work of prior study based on 4 degree-of-freedom Jeffcott rotor system. With consideration of disk tilting and gyroscopic effect, 6-dof EOM is derived and the crack model is established using SERR (strain energy release rate) in facture mechanics. Same as the prior work, the damaged stiffness matrix is updated by computing the instant crack closure line through Zero Stress Intensity Factor method. The breathing crack area is taken as a variable to analyze the breathing behavior in terms of eccentricity phase and shaft speed. Furthermore, the coupled vibration among lateral, torsional and longitudinal d.o.f is studied under torsional/axial excitation. The final part demonstrates the possibility of using vibration signal of damaged system for the crack diagnosis and health monitoring.

Ontology to relational database transformation for web application development and maintenance

NASA Astrophysics Data System (ADS)

Mahmudi, Kamal; Inggriani Liem, M. M.; Akbar, Saiful

2018-03-01

Ontology is used as knowledge representation while database is used as facts recorder in a KMS (Knowledge Management System). In most applications, data are managed in a database system and updated through the application and then they are transformed to knowledge as needed. Once a domain conceptor defines the knowledge in the ontology, application and database can be generated from the ontology. Most existing frameworks generate application from its database. In this research, ontology is used for generating the application. As the data are updated through the application, a mechanism is designed to trigger an update to the ontology so that the application can be rebuilt based on the newest ontology. By this approach, a knowledge engineer has a full flexibility to renew the application based on the latest ontology without dependency to a software developer. In many cases, the concept needs to be updated when the data changed. The framework is built and tested in a spring java environment. A case study was conducted to proof the concepts.

Effects of fire, insect, and pathogen damage on wood quality of dead and dying western conifers

Treesearch

Eini C. Lowell; Valerie A. Rapp; Richard W. Haynes; Caitlin Cray

2010-01-01

We update and expand the 1992 survey of research findings by Lowell and colleagues, providing an ecological context for the findings, using a more reader-friendly format, and including extensive citations so readers can get indepth information on particular topics. Our intent is that managers will use this report as a desktop reference and field guide. The worksheet...

Update Direct-Strike Lightning Environment for Stockpile-to-Target Sequence: Supplement LLNL Subcontract #B568621 Lightning Protection at the Yucca Mountain Waste Storage Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uman, M A

2008-10-09

The University of Florida has surveyed all relevant publications reporting lightning damage to metals, metals which could be used as components of storage containers for nuclear waste materials. We show that even the most severe lightning could not penetrate the stainless steel thicknesses proposed for nuclear waste storage casks.

Updating the Theoretical Content of Teacher Preparation Pertaining to Educational Subjects: Some Recent Developments in Estonia. Reprints and Miniprints No. 754.

ERIC Educational Resources Information Center

Krull, Edgar

Fifty years of Soviet occupation in Estonia has damaged social and economic life. One issue for further development of Estonian society is the need to reform teacher education programs. This paper outlines some of the main problems concerning the content of theoretical preparation of future teachers in educational subjects at Tartu University…

An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barré syndrome

PubMed Central

Zhang, Gang

2010-01-01

Anti-glycan antibodies directed against gangliosides are now considered the major immune effectors that induce damage to intact nerve fibers in some variants of the monophasic neuropathic disorders that comprise Guillain-Barré syndrome. Recent experimental studies elucidating the complexity of anti-glycan antibody-mediated pathobiologic effects on intact and injured nerves undergoing repair are discussed. PMID:20948812

Historical sources on climate and extreme events before XX century in Calabria (Italy)

NASA Astrophysics Data System (ADS)

Aurora Pasqua, Angela; Petrucci, Olga

2014-05-01

Damaging Hydrogeological Events (DHEs) are defined as the occurrence of destructive phenomena, such as landslides and floods, triggered by extreme rain events. Due to the huge damage that they can cause to people and properties, DHEs are often described in a wide series of historical sources. The historical series of DHEs that affected a study region can supply useful information about the climatic trend of the area. Moreover, it can reveals temporal and spatial increases in vulnerability affecting sectors where urbanization increased throughout the time. On the other side, it can highlight further vulnerability variations occurred throughout the decades and related to specific defensive measures undertaken (or abandoned) in order to prevent damage caused by either landslides or floods. We present the historical series of catastrophic DHEs which affected a Mediterranean region named Calabria that is located in southern Italy. Data presented came from the database named ASICal (the Italian acronym of historically flooded areas in Calabria) that has been built at the beginning of 2000 at CNR-IRPI of Cosenza and that has been continuously updated since then. Currently, this database includes more than 11,000 records about floods and landslides which have been occurred in Calabria since the XVI century. These data came from different information sources as newspapers, archives of regional and national agencies, scientific and technical reports, on-site surveys reports and so on. ASICal is constantly updated. The updating concerns both current DHEs that every years affect the region, and the results of specific historical research that we regularly perform in order to fill data gaps for older epochs. In this work we present the result of a recent survey carried out in some regional public libraries focusing on the early-mid XIX century. The type of data sources available for the regional framework are described and a sketch of the DHEs trend during the last three centuries is presented. Moreover, a panoramic view of both proxy data and irregularly measured parameters concerning climatic trend of the region obtained from the analyzed historical sources is also shown.

Nonadditive entropy maximization is inconsistent with Bayesian updating

NASA Astrophysics Data System (ADS)

Pressé, Steve

2014-11-01

The maximum entropy method—used to infer probabilistic models from data—is a special case of Bayes's model inference prescription which, in turn, is grounded in basic propositional logic. By contrast to the maximum entropy method, the compatibility of nonadditive entropy maximization with Bayes's model inference prescription has never been established. Here we demonstrate that nonadditive entropy maximization is incompatible with Bayesian updating and discuss the immediate implications of this finding. We focus our attention on special cases as illustrations.

Nonadditive entropy maximization is inconsistent with Bayesian updating.

PubMed

Pressé, Steve

2014-11-01

The maximum entropy method-used to infer probabilistic models from data-is a special case of Bayes's model inference prescription which, in turn, is grounded in basic propositional logic. By contrast to the maximum entropy method, the compatibility of nonadditive entropy maximization with Bayes's model inference prescription has never been established. Here we demonstrate that nonadditive entropy maximization is incompatible with Bayesian updating and discuss the immediate implications of this finding. We focus our attention on special cases as illustrations.

Thresholds for thermal damage to normal tissues: an update.

PubMed

Yarmolenko, Pavel S; Moon, Eui Jung; Landon, Chelsea; Manzoor, Ashley; Hochman, Daryl W; Viglianti, Benjamin L; Dewhirst, Mark W

2011-01-01

The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the consecutive years from 2002-2009. The first review on this subject was published in 2003. It included an extensive discussion of how to use thermal dosimetric principles to normalise all time-temperature data histories to a common format. This review utilises those same principles to address sensitivity of a variety of tissues, but with particular emphasis on brain and testis. The review includes new data on tissues that were not included in the original review. Several important observations have come from this review. First, a large proportion of the papers examined for this review were discarded because time-temperature history at the site of thermal damage assessment was not recorded. It is strongly recommended that future research on this subject include such data. Second, very little data is available examining chronic consequences of thermal exposure. On a related point, the time of assessment of damage after exposure is critically important for assessing whether damage is transient or permanent. Additionally, virtually no data are available for repeated thermal exposures which may occur in certain recreational or occupational activities. For purposes of regulatory guidelines, both acute and lasting effects of thermal damage should be considered.

Satellite imagery-based monitoring of archaeological site damage in the Syrian civil war

PubMed Central

Laugier, Elise Jakoby

2017-01-01

Since the start of the Syrian civil war in 2011, the rich archaeological heritage of Syria and northern Iraq has faced severe threats, including looting, combat-related damage, and intentional demolition of monuments. However, the inaccessibility of the conflict zone to archaeologists or cultural heritage specialists has made it difficult to produce accurate damage assessments, impeding efforts to develop mitigation strategies and policies. This paper presents results of a project, undertaken in collaboration with the American Schools of Oriental Research (ASOR) and the US Department of State, to monitor damage to archaeological sites in Syria, northern Iraq, and southern Turkey using recent, high-resolution satellite imagery. Leveraging a large database of archaeological and heritage sites throughout the region, as well as access to continually updated satellite imagery from DigitalGlobe, this project has developed a flexible and efficient methodology to log observations of damage in a manner that facilitates spatial and temporal queries. With nearly 5000 sites carefully evaluated, analysis reveals unexpected patterns in the timing, severity, and location of damage, helping us to better understand the evolving cultural heritage crisis in Syria and Iraq. Results also offer a model for future remote sensing-based archaeological and heritage monitoring efforts in the Middle East and beyond. PMID:29190783

Satellite imagery-based monitoring of archaeological site damage in the Syrian civil war.

PubMed

Casana, Jesse; Laugier, Elise Jakoby

2017-01-01

Since the start of the Syrian civil war in 2011, the rich archaeological heritage of Syria and northern Iraq has faced severe threats, including looting, combat-related damage, and intentional demolition of monuments. However, the inaccessibility of the conflict zone to archaeologists or cultural heritage specialists has made it difficult to produce accurate damage assessments, impeding efforts to develop mitigation strategies and policies. This paper presents results of a project, undertaken in collaboration with the American Schools of Oriental Research (ASOR) and the US Department of State, to monitor damage to archaeological sites in Syria, northern Iraq, and southern Turkey using recent, high-resolution satellite imagery. Leveraging a large database of archaeological and heritage sites throughout the region, as well as access to continually updated satellite imagery from DigitalGlobe, this project has developed a flexible and efficient methodology to log observations of damage in a manner that facilitates spatial and temporal queries. With nearly 5000 sites carefully evaluated, analysis reveals unexpected patterns in the timing, severity, and location of damage, helping us to better understand the evolving cultural heritage crisis in Syria and Iraq. Results also offer a model for future remote sensing-based archaeological and heritage monitoring efforts in the Middle East and beyond.

Suicide and reputation damage.

PubMed

Pridmore, Saxby; McArthur, Milford

2008-10-01

This paper uses the public record to explore the relationship between reputation damage and suicide. The public record of the last 20 years was examined for examples of individuals without evidence of mental disorder who suffered actual or threatened reputation damage and suicided shortly thereafter. Fifteen individual cases were identified; 18 additional cases, less comprehensively detailed, were mentioned in reports of The Wood Royal Commission and Operation Auxin. All cases were male. Of the 15 individual cases, the average age was 55 years, with a range of 40 to 76 years. The available details of the 18 additional cases were consistent with these findings. Middle-aged males without clear evidence of mental disorder, who suffer actual or threatened reputation damage, may be at increased risk of suicide. Naming and shaming needs to be conducted with caution.

Impact of casing damaging on aflatoxin B1 concentration during the ripening of dry-fermented meat sausages.

PubMed

Pleadin, Jelka; Kovačević, Dragan; Perković, Irena

2015-01-01

The aim of this article is to investigate the impact of casing damaging on the formation of aflatoxin B1 (AFB1) during the ripening of dry-fermented meat sausages. The level of AFB1 contamination was determined in 24 samples using the ELISA immunoassay throughout a six-month production period. While with intact casing samples no contamination was observed throughout the whole production process, in damaged casing samples AFB1 was detected in the ripening end-stages in the range of 1.62-4.49 μg/kg. The results showed that casing damaging occurring during long-term ripening of dry-fermented sausages can cause AFB1 contamination, possibly arising on the grounds of diffusion of this mycotoxin from the product surface to its interior.

Plant-parasitic nematodes associated with olive tree (Olea europaea L.) with a focus on the Mediterranean Basin: a review.

PubMed

Ali, Nadine; Chapuis, Elodie; Tavoillot, Johannes; Mateille, Thierry

2014-01-01

The olive tree (Olea europaea ssp. europaea.) is one of the most ancient cultivated trees. It is an emblematic species owing to its ecological, economic and cultural importance, especially in the Mediterranean Basin. Plant-parasitic nematodes are major damaging pests on olive trees, mainly in nurseries. They significantly contribute to economic losses in the top-ten olive-producing countries in the world. However, the damages they induce in orchards and nurseries are specifically documented only in a few countries. This review aims to update knowledge about the olive-nematode pathosystem by: (1) updating the list of plant-parasitic nematodes associated with olive trees; (2) analysing their diversity (taxonomic level, trophic groups, dominance of taxa), which allowed us (i) to assess the richness observed in each country, and (ii) to exhibit and describe the most important taxa able to induce damages on olive trees such as: Meloidogyne, Pratylenchus, Helicotylenchus, Xiphinema, Tylenchulus, Rotylenchulus, Heterodera (distribution especially in the Mediterranean Basin, pathogenicity and reactions of olive trees); (3) describing some management strategies focusing on alternative control methods; (4) suggesting new approaches for controlling plant-parasitic nematodes based on the management of the diversity of their communities, which are structured by several environmental factors such as olive diversity (due to domestication of wild olive in the past, and to breeding now), cropping systems (from traditional to high-density orchards), irrigation, and terroirs. Copyright © 2014 Académie des sciences. Published by Elsevier SAS. All rights reserved.

Flood loss model transfer: on the value of additional data

NASA Astrophysics Data System (ADS)

Schröter, Kai; Lüdtke, Stefan; Vogel, Kristin; Kreibich, Heidi; Thieken, Annegret; Merz, Bruno

2017-04-01

The transfer of models across geographical regions and flood events is a key challenge in flood loss estimation. Variations in local characteristics and continuous system changes require regional adjustments and continuous updating with current evidence. However, acquiring data on damage influencing factors is expensive and therefore assessing the value of additional data in terms of model reliability and performance improvement is of high relevance. The present study utilizes empirical flood loss data on direct damage to residential buildings available from computer aided telephone interviews that were carried out after the floods in 2002, 2005, 2006, 2010, 2011 and 2013 mainly in the Elbe and Danube catchments in Germany. Flood loss model performance is assessed for incrementally increased numbers of loss data which are differentiated according to region and flood event. Two flood loss modeling approaches are considered: (i) a multi-variable flood loss model approach using Random Forests and (ii) a uni-variable stage damage function. Both model approaches are embedded in a bootstrapping process which allows evaluating the uncertainty of model predictions. Predictive performance of both models is evaluated with regard to mean bias, mean absolute and mean squared errors, as well as hit rate and sharpness. Mean bias and mean absolute error give information about the accuracy of model predictions; mean squared error and sharpness about precision and hit rate is an indicator for model reliability. The results of incremental, regional and temporal updating demonstrate the usefulness of additional data to improve model predictive performance and increase model reliability, particularly in a spatial-temporal transfer setting.

Update on the biologic role of the vitamin D endocrine system.

PubMed

Dusso, Adriana S

2014-03-01

The integrity of the vitamin D endocrine system is essential for human health. Nutritional vitamin D deficiency in otherwise healthy individuals, associates with a higher risk of mortality for all causes, despite normal serum calcitriol. These deadly causes extend beyond the recognized adverse impact of vitamin D deficiency on calcium and phosphate homeostasis predisposing to secondary hyperparathyroidism, bone loss and vascular calcification. Vitamin D deficiency also associates with an early onset of disorders of aging, including hypertension, proteinuria, insulin resistance, immune abnormalities that enhance the propensity for viral and bacterial infections, autoimmune disorders, cancer, and multiple organ damage due to excessive systemic inflammation causing atherosclerosis, vascular stiffness, renal lesions, and impaired DNA-damage responses. The frequency and severity of all of these disorders markedly increase in chronic kidney disease (CKD) because the kidney is essential to maintain serum levels of calcitriol, the most potent endogenous endocrine activator of the vitamin D receptor (VDR), and also of 25-hydroxyvitamin D, for local rather than systemic VDR activation. The goal of this review is to update the current understanding of the pathophysiology behind the classical and non-classical actions of VDR activation that help prevent the onset and/or attenuate the progression of renal and cardiovascular damage in CKD. This knowledge is essential to identify non-invasive, sensitive and accurate biomarkers of the severity of these disorders, a first step to generate evidence-based recommendations for a safe correction of vitamin D and/or calcitriol deficiency in the course of CKD that effectively improves outcomes.

Mechanisms of MDMA (Ecstasy)-Induced Oxidative Stress, Mitochondrial Dysfunction, and Organ Damage

PubMed Central

Song, Byoung-Joon; Moon, Kwan-Hoon; Upreti, Vijay V.; Eddington, Natalie D.; Lee, Insong J.

2010-01-01

Despite numerous reports about the acute and sub-chronic toxicities caused by MDMA (3,4-methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is poorly understood. The aim of this review is to present an update of the mechanistic studies on MDMA-mediated organ damage partly caused by increased oxidative/nitrosative stress. Because of the extensive reviews on MDMA-mediated oxidative stress and tissue damage, we specifically focus on the mechanisms and consequences of oxidative-modifications of mitochondrial proteins, leading to mitochondrial dysfunction. We briefly describe a method to systematically identify oxidatively-modified mitochondrial proteins in control and MDMA-exposed rats by using biotin-N-maleimide (biotin-NM) as a sensitive probe for oxidized proteins. We also describe various applications and advantages of this Cys-targeted proteomics method and alternative approaches to overcome potential limitations of this method in studying oxidized proteins from MDMA-exposed tissues. Finally we discuss the mechanism of synergistic drug-interaction between MDMA and other abused substances including alcohol (ethanol) as well as application of this redox-based proteomics method in translational studies for developing effective preventive and therapeutic agents against MDMA-induced organ damage. PMID:20420575

Benefits of dietary phytochemical supplementation on eccentric exercise-induced muscle damage: Is including antioxidants enough?

PubMed

Pereira Panza, Vilma Simões; Diefenthaeler, Fernando; da Silva, Edson Luiz

2015-09-01

The purpose of this review was to critically discuss studies that investigated the effects of supplementation with dietary antioxidant phytochemicals on recovery from eccentric exercise-induced muscle damage. The performance of physical activities that involve unaccustomed eccentric muscle actions-such as lowering a weight or downhill walking-can result in muscle damage, oxidative stress, and inflammation. These events may be accompanied by muscle weakness and delayed-onset muscle soreness. According to the current evidences, supplementation with dietary antioxidant phytochemicals appears to have the potential to attenuate symptoms associated with eccentric exercise-induced muscle damage. However, there are inconsistencies regarding the relationship between muscle damage and blood markers of oxidative stress and inflammation. Furthermore, the effectiveness of strategies appear to depend on a number of aspects inherent to phytochemical compounds as well as its food matrix. Methodological issues also may interfere with the proper interpretation of supplementation effects. Thus, the study may contribute to updating professionals involved in sport nutrition as well as highlighting the interest of scientists in new perspectives that can widen dietary strategies applied to training. Copyright © 2015 Elsevier Inc. All rights reserved.

Breaking new ground for remote sensing in support of disaster relief efforts: Detecting and pinpointing earthquake damage in near real-time (El Salvador, January 2001)

NASA Astrophysics Data System (ADS)

Nezry, Edmond; Romeijn, Paul P.; Sarti, Francesco; Inglada, Jordi; Zagolski, Francis; Yakam-Simen, Francis

2002-01-01

On January 13th 2001, a very strong earthquake struck El-Salvador, causing almost 1000 deaths and huge destruction, leaving more than one million people homeless. As support to the rescue teams, a project was initiated to provide up-to date maps and to identify damages to housing and infrastructures, covering the whole country. Based on the analysis of SPOT Panchromatic satellite imagery, updated maps were delivered to the rescue teams within 72 hours after the earthquake. In addition, during the 10 days following the earthquake, high resolution mapping of the damages was carried out in cooperation and coordination with rescue teams and relief organizations. Some areas of particular interest were even processed and damage maps delivered through the Internet, three hours after the request. For the first time in the history of spaceborne Earth observation, identification and evaluation of the damages were delivered on-site, in real-time (during the interventions), to local authorities, rescue teams and humanitarian organizations. In this operation, operating 24 hours a day and technical ability were the keys for success and contributed to saving lives.

OSATE Overview & Community Updates

DTIC Science & Technology

2015-02-15

update 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Delange /Julien 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...main language capabilities Modeling patterns & model samples for beginners Error-Model examples EMV2 model constructs Demonstration of tools Case

Update '98.

ERIC Educational Resources Information Center

Mock, Karen R.

1998-01-01

Updates cases and issues previously discussed in this regular column on human rights in Canada, including racism and anti-Semitism, laws on hate crimes, hate sites on the World Wide Web, the use of the "free speech" defense by hate groups, and legal challenges to antiracist groups by individuals criticized by them. (DSK)

29 CFR 1904.33 - Retention and updating.

Code of Federal Regulations, 2012 CFR

2012-07-01

... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original entry...

29 CFR 1904.33 - Retention and updating.

Code of Federal Regulations, 2014 CFR

2014-07-01

... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original entry...

29 CFR 1904.33 - Retention and updating.

Code of Federal Regulations, 2013 CFR

2013-07-01

... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original entry...

Landsat Imagery: A Tool for Updating Land Use in Gulf Coast Mexico

ERIC Educational Resources Information Center

Harnapp, Vern

1978-01-01

Explores the use of Landsat imagery in mapping and updating land use for the purpose of planning. Examines Gulf Coast Mexico as a case study, because modern agricultural techniques used to expand the ranching industry have significantly altered the landscape. (Author/BC)

An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document.

PubMed

Campistol, Josep M; Arias, Manuel; Ariceta, Gema; Blasco, Miguel; Espinosa, Laura; Espinosa, Mario; Grinyó, Josep M; Macía, Manuel; Mendizábal, Santiago; Praga, Manuel; Román, Elena; Torra, Roser; Valdés, Francisco; Vilalta, Ramón; Rodríguez de Córdoba, Santiago

2015-01-01

Haemolytic uraemic syndrome (HUS) is a clinical entity defined as the triad of nonimmune haemolytic anaemia, thrombocytopenia, and acute renal failure, in which the underlying lesions are mediated by systemic thrombotic microangiopathy (TMA). Different causes can induce the TMA process that characterizes HUS. In this document we consider atypical HUS (aHUS) a sub-type of HUS in which the TMA phenomena are the consequence of the endotelial damage in the microvasculature of the kidneys and other organs due to a disregulation of the activity of the complement system. In recent years, a variety of aHUs-related mutations have been identified in genes of the the complement system, which can explain approximately 60% of the aHUS cases, and a number of mutations and polymorphisms have been functionally characterized. These findings have stablished that aHUS is a consequence of the insufficient regulation of the activiation of the complement on cell surfaces, leading to endotelial damage mediated by C5 and the complement terminal pathway. Eculizumab is a monoclonal antibody that inhibits the activation of C5 and blocks the generation of the pro-inflammatory molecule C5a and the formation of the cell membrane attack complex. In prospective studies in patients with aHUS, the use of Eculizumab has shown a fast and sustained interruption of the TMA process and it has been associated with significative long-term improvements in renal function, the interruption of plasma therapy and important reductions in the need of dialysis. According to the existing literature and the accumulated clinical experience, the Spanish aHUS Group published a consensus document with recommendations for the treatment of aHUs (Nefrologia 2013;33[1]:27-45). In the current online version of this document, we update the aetiological classification of TMAs, the pathophysiology of aHUS, its differential diagnosis and its therapeutic management. Copyright © 2015 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

[Damage to cranial and peripheral nerves following patency restoration of the internal carotid artery].

PubMed

Myrcha, P; Ciostek, P; Szopiński, P; Noszczyk, W

2001-01-01

The aim of the study was an assessment of the incidence of injury to cranial and peripheral nerves as complication of patency restoration of the internal carotid artery, and analysis of the effect of peripheral nerve injury on the results of carotid patency restoration. From Oct 1987 to Sept 1999 543 procedures were carried out for restoration of patency of the internal carotid artery. After the operation hypoglossus nerve injury was found in 7 cases (1.4%), vagus injury in 9 (1.8%). Signs of exclusively recurrent laryngeal nerve damage were found in 6 cases (1.2%). Glossopharyngeus nerve was damaged in 2 cases (0.4%), transient phrenic nerve palsy as a result of conduction anaesthesia was noted in 2 cases (0.4%). Damage to the transverse cervical nerve was found in 96 cases (60%). In 2 patients (1.2%) lower position of mouth angle was due to section of the mandibular ramus of the facial nerve. In another 2 cases skin sensation disturbances were a consequence of lesion of the auricularis magnus nerve and always they coexisted with signs of transverse cervical nerve damage. damage to the cranial nerves during operation for carotid patency restoration are frequent but mostly they are not connected with any health risks and often they regress spontaneously.

Fast model updating coupling Bayesian inference and PGD model reduction

NASA Astrophysics Data System (ADS)

Rubio, Paul-Baptiste; Louf, François; Chamoin, Ludovic

2018-04-01

The paper focuses on a coupled Bayesian-Proper Generalized Decomposition (PGD) approach for the real-time identification and updating of numerical models. The purpose is to use the most general case of Bayesian inference theory in order to address inverse problems and to deal with different sources of uncertainties (measurement and model errors, stochastic parameters). In order to do so with a reasonable CPU cost, the idea is to replace the direct model called for Monte-Carlo sampling by a PGD reduced model, and in some cases directly compute the probability density functions from the obtained analytical formulation. This procedure is first applied to a welding control example with the updating of a deterministic parameter. In the second application, the identification of a stochastic parameter is studied through a glued assembly example.

Criticality and Chaos in Systems of Communities

NASA Astrophysics Data System (ADS)

Ostilli, Massimo; Figueiredo, Wagner

2016-01-01

We consider a simple model of communities interacting via bilinear terms. After analyzing the thermal equilibrium case, which can be described by an Hamiltonian, we introduce the dynamics that, for Ising-like variables, reduces to a Glauber-like dynamics. We analyze and compare four different versions of the dynamics: flow (differential equations), map (discretetime dynamics), local-time update flow, and local-time update map. The presence of only bilinear interactions prevent the flow cases to develop any dynamical instability, the system converging always to the thermal equilibrium. The situation is different for the map when unfriendly couplings are involved, where period-two oscillations arise. In the case of the map with local-time updates, oscillations of any period and chaos can arise as a consequence of the reciprocal “tension” accumulated among the communities during their sleeping time interval. The resulting chaos can be of two kinds: true chaos characterized by positive Lyapunov exponent and bifurcation cascades, or marginal chaos characterized by zero Lyapunov exponent and critical continuous regions.

Punitive Damages in Civil Rights Actions.

ERIC Educational Resources Information Center

Frels, Kelly

Punitive damages have been permitted in certain cases to deter wrongdoers from similar conduct in the future. The Supreme Court decision in the case of "Smith vs. Wade" set the standard for the award of punitive damages by permitting punitive award on varying standards of negligence, gross negligence, recklessness, or other culpable…

Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement.

PubMed

Flack, John M; Sica, Domenic A; Bakris, George; Brown, Angela L; Ferdinand, Keith C; Grimm, Richard H; Hall, W Dallas; Jones, Wendell E; Kountz, David S; Lea, Janice P; Nasser, Samar; Nesbitt, Shawna D; Saunders, Elijah; Scisney-Matlock, Margaret; Jamerson, Kenneth A

2010-11-01

Since the first International Society on Hypertension in Blacks consensus statement on the "Management of High Blood Pressure in African American" in 2003, data from additional clinical trials have become available. We reviewed hypertension and cardiovascular disease prevention and treatment guidelines, pharmacological hypertension clinical end point trials, and blood pressure-lowering trials in blacks. Selected trials without significant black representation were considered. In this update, blacks with hypertension are divided into 2 risk strata, primary prevention, where elevated blood pressure without target organ damage, preclinical cardiovascular disease, or overt cardiovascular disease for whom blood pressure consistently <135/85 mm Hg is recommended, and secondary prevention, where elevated blood pressure with target organ damage, preclinical cardiovascular disease, and/or a history of cardiovascular disease, for whom blood pressure consistently <130/80 mm Hg is recommended. If blood pressure is ≤10 mm Hg above target levels, monotherapy with a diuretic or calcium channel blocker is preferred. When blood pressure is >15/10 mm Hg above target, 2-drug therapy is recommended, with either a calcium channel blocker plus a renin-angiotensin system blocker or, alternatively, in edematous and/or volume-overload states, with a thiazide diuretic plus a renin-angiotensin system blocker. Effective multidrug therapeutic combinations through 4 drugs are described. Comprehensive lifestyle modifications should be initiated in blacks when blood pressure is ≥115/75 mm Hg. The updated International Society on Hypertension in Blacks consensus statement on hypertension management in blacks lowers the minimum target blood pressure level for the lowest-risk blacks, emphasizes effective multidrug regimens, and de-emphasizes monotherapy.

Fundamentals of Collection Development and Management. Second Edition

ERIC Educational Resources Information Center

Johnson, Peggy

2009-01-01

In this fully updated revision, expert instructor and librarian Peggy Johnson addresses the art in controlling and updating your library's collection. Each chapter offers complete coverage of one aspect of collection development, including suggestions for further reading and a narrative case study exploring the issue. Johnson also integrates…

Special Education Law Update II.

ERIC Educational Resources Information Center

Zirkel, Perry A.

1991-01-01

An annotated outline provides recent case law in special education since the last update in volume 56 of this journal. Based on the 1990 amendments to the Education of the Handicapped Act (EHA), references are in the form of the acronym for its new title, the Individuals with Disabilities Education Act (IDEA). (MLF)

Legal Update of Gifted Education

ERIC Educational Resources Information Center

Zirkel, Perry A.

2016-01-01

This update of the legislation/regulations and case law specific to pre-K-12 gifted students since a cluster of publications in 2004-2005 primarily focuses on the "gifted alone" category, with only secondary attention to twice-exceptional and other students in the "gifted plus" category. For the gifted-alone category, the…

Updates in the War against Terrorism.

ERIC Educational Resources Information Center

Strickland, Lee S.

2002-01-01

Provides an update of new court cases related to Part IV of the series on Information and the War Against Terrorism. Discusses civil liberties versus security involving the legality of mandatory commercial use of biometrics as identification; and communication of privileged information between a person and his or her attorney. (LRW)

Mechanism of action of recombinant activated factor VII: an update.

PubMed

Hedner, Ulla

2006-01-01

Bleeding episodes in patients with hemophilia and inhibitors must be managed using agents that are hemostatically active in the absence of factor VIII or IX. Activated prothrombin complex concentrates have long been used in this context. However, the search for safer and more effective agents has led to the development of recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark). This paper presents an update on the mechanism of action of rFVIIa, and describes how pharmacologic doses of this agent enhance thrombin production and thus contribute to the development of a stable, lysis-resistant fibrin plug at the site of vessel damage. This mechanism explains the reported efficacy of rFVIIa in a range of clinical situations characterized by impaired thrombin generation.

2016 update on induced earthquakes in the United States

USGS Publications Warehouse

Petersen, Mark D.

2016-01-01

During the past decade people living in numerous locations across the central U.S. experienced many more small to moderate sized earthquakes than ever before. This earthquake activity began increasing about 2009 and peaked during 2015 and into early 2016. For example, prior to 2009 Oklahoma typically experienced 1 or 2 small earthquakes per year with magnitude greater than 3.0 but by 2015 this number rose to over 900 earthquakes per year of that size and over 30 earthquakes greater than 4.0. These earthquakes can cause damage. In 2011 a magnitude 5.6 earthquake struck near the town of Prague, Oklahoma on a preexisting fault and caused severe damage to several houses and school buildings. During the past 6 years more than 1500 reports of damaging shaking levels were reported in areas of induced seismicity. This rapid increase and the potential for damaging ground shaking from induced earthquakes caused alarm to about 8 million people living nearby and officials responsible for public safety. They wanted to understand why earthquakes were increasing and the potential threats to society and buildings located nearby.

Scaling future tropical cyclone damage with global mean temperature

NASA Astrophysics Data System (ADS)

Geiger, T.; Bresch, D.; Frieler, K.

2017-12-01

Tropical cyclones (TC) are one of the most damaging natural hazards and severely affectmany countries around the globe each year. Their nominal impact is projected to increasesubstantially as the exposed coastal population grows, per capita income increases, andanthropogenic climate change manifests. The magnitude of this increase, however, variesacross regions and is obscured by the stochastic behaviour of TCs, so far impeding arigorous quantification of trends in TC damage with global mean temperature (GMT) rise. Here, we build on the large sample of spatially explicit TCs simulations generated withinISIMIP(2b) for 1) pre-industrial conditions, 2) the historical period, and 3) future projectionsunder RCP2.6 and RCP6.0 to estimate future TC damage assuming fixed present-daysocio-economic conditions or SSP-based future projections of population patterns andincome. Damage estimates will be based on region-specific empirical damage modelsderived from reported damages and accounting for regional characteristics of vulnerability.Different combinations of 1) socio-economic drivers with pre-industrial climate or 2) changingclimate with fixed socio-economic conditions will be used to derive functional relationshipsbetween regionally aggregated changes in damages on one hand and global meantemperature and socio-economic predictors on the other hand. The obtained region-specific scaling of future TC damage with GMT provides valuable inputfor IPCC's special report on the impacts of global warming of 1.5°C by quantifying theincremental changes in impact with global warming. The approach allows for an update ofdamage functions used in integrated assessment models, and contributes to assessing theadequateness of climate mitigation and adaptation strategies.

Low-Level Analytical Methodology Updates to Support Decontaminant Performance Evaluations

DTIC Science & Technology

2011-06-01

from EPDM and tire rubber coupon materials that were spiked with a known amount of the chemical agent VX, treated with bleach decontaminant, and...to evaluate the performance of bleach decontaminant on EPDM and tire rubber coupons. Dose-confirmation or Tool samples were collected by delivering...components • An aging or damaged analytical column • Dirty detector • Other factors related to general instrument and/or sample analysis performance

Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts.

PubMed

Barja, Gustavo

2013-10-20

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity is reviewed. Key aspects of the theory are emphasized. Another main focus concerns common misconceptions that can mislead investigators from other specialties, even to wrongly discard the theory. Those different issues include (i) the main reactive oxygen species (ROS)-generating site in the respiratory chain in relation to aging and longevity: complex I; (ii) the close vicinity or even contact between that site and the mitochondrial DNA, in relation to the lack of local efficacy of antioxidants and to sub-cellular compartmentation; (iii) the relationship between mitochondrial ROS production and oxygen consumption; (iv) recent criticisms on the MFRTA; (v) the widespread assumption that ROS are simple "by-products" of the mitochondrial respiratory chain; (vi) the unnecessary postulation of "vicious cycle" hypotheses of mitochondrial ROS generation which are not central to the free radical theory of aging; and (vii) the role of DNA repair concerning endogenous versus exogenous damage. After considering the large body of data already available, two general characteristics responsible for the high maintenance degree of long-lived animals emerge: (i) a low generation rate of endogenous damage: and (ii) the possession of tissue macromolecules that are highly resistant to oxidative modification.

Medicare and Medicaid Programs; CY 2017 Home Health Prospective Payment System Rate Update; Home Health Value-Based Purchasing Model; and Home Health Quality Reporting Requirements. Final rule.

PubMed

2016-11-03

This final rule updates the Home Health Prospective Payment System (HH PPS) payment rates, including the national, standardized 60-day episode payment rates, the national per-visit rates, and the non-routine medical supply (NRS) conversion factor; effective for home health episodes of care ending on or after January 1, 2017. This rule also: Implements the last year of the 4-year phase-in of the rebasing adjustments to the HH PPS payment rates; updates the HH PPS case-mix weights using the most current, complete data available at the time of rulemaking; implements the 2nd-year of a 3-year phase-in of a reduction to the national, standardized 60-day episode payment to account for estimated case-mix growth unrelated to increases in patient acuity (that is, nominal case-mix growth) between CY 2012 and CY 2014; finalizes changes to the methodology used to calculate payments made under the HH PPS for high-cost "outlier" episodes of care; implements changes in payment for furnishing Negative Pressure Wound Therapy (NPWT) using a disposable device for patients under a home health plan of care; discusses our efforts to monitor the potential impacts of the rebasing adjustments; includes an update on subsequent research and analysis as a result of the findings from the home health study; and finalizes changes to the Home Health Value-Based Purchasing (HHVBP) Model, which was implemented on January 1, 2016; and updates to the Home Health Quality Reporting Program (HH QRP).

Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

PubMed

Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

2017-10-01

To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

Uncertainty in flood damage estimates and its potential effect on investment decisions

NASA Astrophysics Data System (ADS)

Wagenaar, D. J.; de Bruijn, K. M.; Bouwer, L. M.; de Moel, H.

2016-01-01

This paper addresses the large differences that are found between damage estimates of different flood damage models. It explains how implicit assumptions in flood damage functions and maximum damages can have large effects on flood damage estimates. This explanation is then used to quantify the uncertainty in the damage estimates with a Monte Carlo analysis. The Monte Carlo analysis uses a damage function library with 272 functions from seven different flood damage models. The paper shows that the resulting uncertainties in estimated damages are in the order of magnitude of a factor of 2 to 5. The uncertainty is typically larger for flood events with small water depths and for smaller flood events. The implications of the uncertainty in damage estimates for flood risk management are illustrated by a case study in which the economic optimal investment strategy for a dike segment in the Netherlands is determined. The case study shows that the uncertainty in flood damage estimates can lead to significant over- or under-investments.

Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments

PubMed Central

Chakraborty, Subhojit; Kolling, Nils; Walton, Mark E; Mitchell, Anna S

2016-01-01

Adaptive decision-making uses information gained when exploring alternative options to decide whether to update the current choice strategy. Magnocellular mediodorsal thalamus (MDmc) supports adaptive decision-making, but its causal contribution is not well understood. Monkeys with excitotoxic MDmc damage were tested on probabilistic three-choice decision-making tasks. They could learn and track the changing values in object-reward associations, but they were severely impaired at updating choices after reversals in reward contingencies or when there were multiple options associated with reward. These deficits were not caused by perseveration or insensitivity to negative feedback though. Instead, monkeys with MDmc lesions exhibited an inability to use reward to promote choice repetition after switching to an alternative option due to a diminished influence of recent past choices and the last outcome to guide future behavior. Together, these data suggest MDmc allows for the rapid discovery and persistence with rewarding options, particularly in uncertain or changing environments. DOI: http://dx.doi.org/10.7554/eLife.13588.001 PMID:27136677

Earthquakes in the Central United States, 1699-2010

USGS Publications Warehouse

Dart, Richard L.; Volpi, Christina M.

2010-01-01

This publication is an update of an earlier report, U.S. Geological Survey (USGS) Geologic Investigation I-2812 by Wheeler and others (2003), titled ?Earthquakes in the Central United States-1699-2002.? Like the original poster, the center of the updated poster is a map showing the pattern of earthquake locations in the most seismically active part of the central United States. Arrayed around the map are short explanatory texts and graphics, which describe the distribution of historical earthquakes and the effects of the most notable of them. The updated poster contains additional, post 2002, earthquake data. These are 38 earthquakes covering the time interval from January 2003 to June 2010, including the Mount Carmel, Illinois, earthquake of 2008. The USGS Preliminary Determination of Epicenters (PDE) was the source of these additional data. Like the I-2812 poster, this poster was prepared for a nontechnical audience and designed to inform the general public as to the widespread occurrence of felt and damaging earthquakes in the Central United States. Accordingly, the poster should not be used to assess earthquake hazard in small areas or at individual locations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Ootegem, Luc; SHERPPA — Ghent University; Verhofstadt, Elsy

Depth–damage-functions, relating the monetary flood damage to the depth of the inundation, are commonly used in the case of fluvial floods (floods caused by a river overflowing). We construct four multivariate damage models for pluvial floods (caused by extreme rainfall) by differentiating on the one hand between ground floor floods and basement floods and on the other hand between damage to residential buildings and damage to housing contents. We do not only take into account the effect of flood-depth on damage, but also incorporate the effects of non-hazard indicators (building characteristics, behavioural indicators and socio-economic variables). By using a Tobit-estimationmore » technique on identified victims of pluvial floods in Flanders (Belgium), we take into account the effect of cases of reported zero damage. Our results show that the flood depth is an important predictor of damage, but with a diverging impact between ground floor floods and basement floods. Also non-hazard indicators are important. For example being aware of the risk just before the water enters the building reduces content damage considerably, underlining the importance of warning systems and policy in this case of pluvial floods. - Highlights: • Prediction of damage of pluvial floods using also non-hazard information • We include ‘no damage cases’ using a Tobit model. • The damage of flood depth is stronger for ground floor than for basement floods. • Non-hazard indicators are especially important for content damage. • Potential gain of policies that increase awareness of flood risks.« less

DNA and chromosome damage induced by bleomycin in mammalian cells: An update.

PubMed

Bolzán, Alejandro D; Bianchi, Martha S

Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors. Because of this, the study of BLM genotoxicity is of practical interest. This antibiotic is an S-independent clastogen and an agent that generates free radicals and induces single- and double-strand breaks in DNA. In the present review, we will summarize our current knowledge concerning the DNA and chromosome damage induced by BLM in mammalian cells, with emphasis on new developments published since 1991. Copyright © 2018 Elsevier B.V. All rights reserved.

Iatrogenic genetic damage of spermatozoa

PubMed Central

O’Flaherty, Cristian

2016-01-01

Different factors can affect sperm morphology and physiology that negatively influence men fertility. Many studies on humans and animals suggest that both radiation and chemotherapy alter sperm chromatin thus promoting significant damage on sperm DNA and, decreasing the level of protamination, thus altering DNA compaction. Spermatozoa from cancer survivors are affected by chemotherapy even years after the end of the treatment. We are exposed to different toxicants present in the environment (products of air pollution, pesticides, plasticizers, etc), which their impact on men reproduction has not been yet established. This chapter aims to update our knowledge on how sperm chromatin structure is modified by external agents and to describe the different strategies available to better study this complex structure in the infertile men. PMID:23955676

Encounters of aircraft with volcanic ash clouds; A compilation of known incidents, 1953-2009

USGS Publications Warehouse

Guffanti, Marianne; Casadevall, Thomas J.; Budding, Karin

2010-01-01

Information about reported encounters of aircraft with volcanic ash clouds from 1953 through 2009 has been compiled to document the nature and scope of risks to aviation from volcanic activity. The information, gleaned from a variety of published and other sources, is presented in database and spreadsheet formats; the compilation will be updated as additional encounters occur and as new data and corrections come to light. The effects observed by flight crews and extent of aircraft damage vary greatly among incidents, and each incident in the compilation is rated according to a severity index. Of the 129 reported incidents, 94 incidents are confirmed ash encounters, with 79 of those having various degrees of airframe or engine damage; 20 are low-severity events that involve suspected ash or gas clouds; and 15 have data that are insufficient to assess severity. Twenty-six of the damaging encounters involved significant to very severe damage to engines and (or) airframes, including nine encounters with engine shutdown during flight. The average annual rate of damaging encounters since 1976, when reporting picked up, has been approximately 2 per year. Most of the damaging encounters occurred within 24 hours of the onset of ash production or at distances less than 1,000 kilometers from the source volcanoes. The compilation covers only events of relatively short duration for which aircraft were checked for damage soon thereafter; documenting instances of long-term repeated exposure to ash (or sulfate aerosols) will require further investigation. Of 38 source volcanoes, 8 have caused 5 or more encounters, of which the majority were damaging: Augustine (United States), Chaiten (Chile), Mount St. Helens (United States), Pacaya (Guatemala), Pinatubo (Philippines), Redoubt (United States), Sakura-jima (Japan), and Soufriere Hills (Montserrat, Lesser Antilles, United Kingdom). Aircraft have been damaged by eruptions ranging from small, recurring episodes to very large, infrequent events. Moderate-size (Volcanic Explosivity Index 3) eruptions are responsible for nearly half of the damaging encounters. Vigilance is required during the early phases of eruptive activity when data about ash emission may be the most limited and warning capabilities the most strained, yet the risk the greatest. The risk-mitigation strategy for minimizing damaging encounters continues to rely on the combination of real-time volcano monitoring and rapid eruption reporting, detection and tracking of ash clouds in the atmosphere using satellite-based sensors, dispersion modeling to forecast expected ash-cloud movement, and global dissemination of specialized warning messages. To obtain the entire Data Series 545 report, download the text file and appendixes 1-4, which are available as separate files. Click on the links at right. Please Send Updates We hope that publication of this compilation will encourage more reporting of encounters by the aviation industry and civil aviation authorities. We actively seek corrections and additions to the information presented here. Persons who have corrections or additional data pertaining to incidents already in the database or who have data about previously unreported incidents are urged to contact the authors.

Copyright Updates for K-12 Librarians

ERIC Educational Resources Information Center

Johnson, Wendell G.

2016-01-01

Copyright concerns continue to bedevil K-12 librarians, who are often called upon to act as the copyright officers in public schools. This article describes recent copyright developments of concern to these librarians in three areas: a recent court case involving a university library, pending legislation supported by ALA, and a regulatory update.…

Postsecondary Transition under IDEA 2004: A Legal Update

ERIC Educational Resources Information Center

Prince, Angela M. T.; Katsiyannis, Antonis; Farmer, Jennie

2013-01-01

Postsecondary transition planning for students with disabilities first entered the Individuals with Disabilities Education Act (IDEA) in 1990. The required provisions for transition planning were updated with the amendments to IDEA in 1997 and its reauthorization in 2004. Since IDEA 2004 took effect in July 2005, 11 court cases have been decided…

77 FR 21782 - International Conference on Harmonisation; Draft Guidance for Industry on E2C(R2) Periodic...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... electronic submission of individual case safety reports to regulatory authorities, automated data mining... Safety Data Management: Periodic Safety Update Reports for Marketed Drugs'' (E2C guidance) and ``Addendum to E2C Clinical Safety Data Management: Periodic Safety Update Reports for Marketed Drugs'' (addendum...

School Finance Litigation across the States: An Update.

ERIC Educational Resources Information Center

Verstegen, D. A., Ed.

This report is an update on eight state-level cases: (1) "School Financier Litigation in Minnesota" (Van D. Mueller), which states students are allowed enhanced access to suburban schools and to Minneapolis magnet schools; (2) "School Finance Litigation across the States--New Hampshire" (Van D. Mueller), which states the court ruled that property…

Distinguishing between damage to clothing as a result of normal wear and tear or as a result of deliberate damage: a sexual assault case study.

PubMed

Daly, Dyan J; Lee-Gorman, Marce A; Ryan, Jennifer

2009-03-01

This paper focuses on bra damage, specifically damage observed in hook and eye fasteners that are generally located at the backstraps of bras. We describe bra design including the method by which hook and eye fasteners are generally constructed. We assess bra damage in two situations where the damage observed was unexpected given the case scenarios. These were: (i) the complainant of an alleged rape attributed damage to her bra hooks to force during a struggle and (ii) the complainant had earlier manipulated her bra hooks in an incident not related to her complaint. Steriomicroscopy and reconstruction experimentation were necessarily used to assess the bra damage. A systematic approach to damage analysis was employed by the forensic practitioners to correctly identify damage as being a result of mechanical manipulation and therefore as falsified. This paper suggests that more examples of falsified damage should be documented.

Uncertainty in flood damage estimates and its potential effect on investment decisions

NASA Astrophysics Data System (ADS)

Wagenaar, Dennis; de Bruijn, Karin; Bouwer, Laurens; de Moel, Hans

2015-04-01

This paper addresses the large differences that are found between damage estimates of different flood damage models. It explains how implicit assumptions in flood damage models can lead to large uncertainties in flood damage estimates. This explanation is used to quantify this uncertainty with a Monte Carlo Analysis. This Monte Carlo analysis uses a damage function library with 272 functions from 7 different flood damage models. This results in uncertainties in the order of magnitude of a factor 2 to 5. This uncertainty is typically larger for small water depths and for smaller flood events. The implications of the uncertainty in damage estimates for flood risk management are illustrated by a case study in which the economic optimal investment strategy for a dike segment in the Netherlands is determined. The case study shows that the uncertainty in flood damage estimates can lead to significant over- or under-investments.

Uncertainty in flood damage estimates and its potential effect on investment decisions

NASA Astrophysics Data System (ADS)

Wagenaar, D. J.; de Bruijn, K. M.; Bouwer, L. M.; De Moel, H.

2015-01-01

This paper addresses the large differences that are found between damage estimates of different flood damage models. It explains how implicit assumptions in flood damage models can lead to large uncertainties in flood damage estimates. This explanation is used to quantify this uncertainty with a Monte Carlo Analysis. As input the Monte Carlo analysis uses a damage function library with 272 functions from 7 different flood damage models. This results in uncertainties in the order of magnitude of a factor 2 to 5. The resulting uncertainty is typically larger for small water depths and for smaller flood events. The implications of the uncertainty in damage estimates for flood risk management are illustrated by a case study in which the economic optimal investment strategy for a dike segment in the Netherlands is determined. The case study shows that the uncertainty in flood damage estimates can lead to significant over- or under-investments.

The Influence of Ballistic Damage on the Aeroelastic Characteristics of Lifting Surfaces.

DTIC Science & Technology

1979-07-01

the pressure distribution. The finite-element method, often referred to as a vortex- lattice or doublet- lattice method, divides the lifting surface into...finite-element modeling, such as doublet- lattice , would provide a better understanding of the near-field effects of a damage hole and allow a data base...0.17 0.33 0.50 6.67 0.833 1.00 Figure 42 125 CASE 5 and CASE 5D 0 Ye=.57 = UNDAMAGED M = DAMAGED 0 C3/ C22 CD QCD 6.330,4 0/ Fiue4 02 CASE 5 and CASE

The position of symbrachydactyly in the classification of congenital hand anomalies.

PubMed

Miura, T; Nakamura, R; Horii, E

1994-06-01

The clinical features of 53 cases of intercalated hypoplasia and 113 cases of distal aplasia are reviewed and compared with each other and with 129 cases of syndactyly. Tri-, di- and mono-phalangeal symbrachydactyly, and adactyly with nubbin digits are consecutive anomalies. Transverse deficiency may result if the mesenchyme is damaged severely, and if damage is mild and formation has continued, intercalated transverse deficiency may occur. Webbing in symbrachydactyly may result from failure of the apical ectodermal ridge under the influence of damaged mesenchyme.

Introducing GEOPHIRES v2.0: Updated Geothermal Techno-Economic Simulation Tool: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckers, Koenraad J; McCabe, Kevin

This paper presents an updated version of the geothermal techno-economic simulation tool GEOPHIRES (GEOthermal Energy for Production of Heat and electricity (IR) Economically Simulated). GEOPHIRES combines reservoir, wellbore, surface plant and economic models to estimate the capital, and operation and maintenance costs, lifetime energy production, and overall levelized cost of energy of a geothermal plant. The available end-use options are electricity, direct-use heat and cogeneration. The main updates in the new version include conversion of the source code from FORTRAN to Python, the option to couple to an external reservoir simulator, updated cost correlations, and more flexibility in selecting themore » time step and number of injection and production wells. An overview of all the updates and two case-studies to illustrate the tool's new capabilities are provided in this paper.« less

Application of Artificial Intelligence for Bridge Deterioration Model.

PubMed

Chen, Zhang; Wu, Yangyang; Li, Li; Sun, Lijun

2015-01-01

The deterministic bridge deterioration model updating problem is well established in bridge management, while the traditional methods and approaches for this problem require manual intervention. An artificial-intelligence-based approach was presented to self-updated parameters of the bridge deterioration model in this paper. When new information and data are collected, a posterior distribution was constructed to describe the integrated result of historical information and the new gained information according to Bayesian theorem, which was used to update model parameters. This AI-based approach is applied to the case of updating parameters of bridge deterioration model, which is the data collected from bridges of 12 districts in Shanghai from 2004 to 2013, and the results showed that it is an accurate, effective, and satisfactory approach to deal with the problem of the parameter updating without manual intervention.

Application of Artificial Intelligence for Bridge Deterioration Model

PubMed Central

Chen, Zhang; Wu, Yangyang; Sun, Lijun

2015-01-01

The deterministic bridge deterioration model updating problem is well established in bridge management, while the traditional methods and approaches for this problem require manual intervention. An artificial-intelligence-based approach was presented to self-updated parameters of the bridge deterioration model in this paper. When new information and data are collected, a posterior distribution was constructed to describe the integrated result of historical information and the new gained information according to Bayesian theorem, which was used to update model parameters. This AI-based approach is applied to the case of updating parameters of bridge deterioration model, which is the data collected from bridges of 12 districts in Shanghai from 2004 to 2013, and the results showed that it is an accurate, effective, and satisfactory approach to deal with the problem of the parameter updating without manual intervention. PMID:26601121

Synchronous parallel spatially resolved stochastic cluster dynamics

DOE PAGES

Dunn, Aaron; Dingreville, Rémi; Martínez, Enrique; ...

2016-04-23

In this work, a spatially resolved stochastic cluster dynamics (SRSCD) model for radiation damage accumulation in metals is implemented using a synchronous parallel kinetic Monte Carlo algorithm. The parallel algorithm is shown to significantly increase the size of representative volumes achievable in SRSCD simulations of radiation damage accumulation. Additionally, weak scaling performance of the method is tested in two cases: (1) an idealized case of Frenkel pair diffusion and annihilation, and (2) a characteristic example problem including defect cluster formation and growth in α-Fe. For the latter case, weak scaling is tested using both Frenkel pair and displacement cascade damage.more » To improve scaling of simulations with cascade damage, an explicit cascade implantation scheme is developed for cases in which fast-moving defects are created in displacement cascades. For the first time, simulation of radiation damage accumulation in nanopolycrystals can be achieved with a three dimensional rendition of the microstructure, allowing demonstration of the effect of grain size on defect accumulation in Frenkel pair-irradiated α-Fe.« less

Normalized spectral damage of a linear system over different spectral loading patterns

NASA Astrophysics Data System (ADS)

Kim, Chan-Jung

2017-08-01

Spectral fatigue damage is affected by different loading patterns; the damage may be accumulated in a different manner because the spectral pattern has an influence on stresses or strains. The normalization of spectral damage with respect to spectral loading acceleration is a novel solution to compare the accumulated fatigue damage over different spectral loading patterns. To evaluate the sensitivity of fatigue damage over different spectral loading cases, a simple notched specimen is used to conduct a uniaxial vibration test for two representative spectral patterns-random and harmonic-between 30 and 3000 Hz. The fatigue damage to the simple specimen is analyzed for different spectral loading cases using the normalized spectral damage from the measured response data for both acceleration and strain. The influence of spectral loading patterns is discussed based on these analyses.

Virus Information Update CIAC-2301

DTIC Science & Technology

1998-05-21

a tune through a sound card. Byway is reported to be in the wild internationally, especially in Venezuela, Mexico , Bulgaria, UK and USA. REMOVAL NOTE...1482, Varicella Type: Program. Disk Location: Features: Damage: Size: See Also: Notes: v6-146: This virus was written to hurt users of the TBCLEAN...antivirus package. If you have a file infected with the Varicella virus, and if you tried to clean this virus infected file with tbclean, what would

Automated Simulation Updates based on Flight Data

NASA Technical Reports Server (NTRS)

Morelli, Eugene A.; Ward, David G.

2007-01-01

A statistically-based method for using flight data to update aerodynamic data tables used in flight simulators is explained and demonstrated. A simplified wind-tunnel aerodynamic database for the F/A-18 aircraft is used as a starting point. Flight data from the NASA F-18 High Alpha Research Vehicle (HARV) is then used to update the data tables so that the resulting aerodynamic model characterizes the aerodynamics of the F-18 HARV. Prediction cases are used to show the effectiveness of the automated method, which requires no ad hoc adjustments by the analyst.

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

Friedman, Paul

The document reports on five new cases and updates information on 29 previously reported cases regarding mental retardation and the law. Cases are divided into the following categories: classification, commitment, confidentiality, education, employment, protection from harm, sterilization, treatment, and zoning. Listed separately, by the above…

[Application of damage control surgery idea in the treatment of severe pancreatic duodenal injury].

PubMed

Zhu, Ren-wu; Gu, Ye-chun; Jiang, Yang-gui; Zhao, Mao-sen; Shen, Xian

2013-12-01

To explore the significance of damage control surgery (DCS) in the treatments of severe pancreaticoduodenal injuries. Clinical data of 19 patients with severe pancreaticoduodenal injuries managed with DCS approach in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine and the First Affiliated Hospital of Wenzhou Medical College from March 2005 to January 2013 were analyzed retrospectively. Three cases were cured after damage control operation and postoperative ICU resuscitation treatment. Twelve cases underwent definite operations (distal pancreaticojejunal Roux-en-Y anastomosis, proximal duodenojejunal Roux-en-Y anastomosis or pancreaticoduodenectomy) after damage control operation and postoperative ICU resuscitation treatment and cured. Four cases died after damage control operation due to multiple organ failure and the mortality was 21.1%. Application of DCS approach can improve the prognosis of patients with severe pancreaticoduodenal injuries.

[Valuation of forest damage cost from SO2 emission: a case study in Hunan Province].

PubMed

Hao, Jiming; Li, Ji; Duan, Lei; He, Kebin; Dai, Wennan

2002-11-01

Large amount SO2 emission caused serious damage of forest ecosystem in China and calculation of the damage cost is an important issue for policy-making. However, no applicable method was developed to estimate forest damage under different SO2 emission scenarios. Basing on previous field researches on sulfur-related forest impact in China and recent critical load mapping research, this paper presented a model for forest damage calculation by developing a dose-response function that related the damage to cumulative sulfur critical loads. This model was applied to the forests in Hunan, a province in acid rain control zone in China. Results showed that in the business-as-usual case, SO2 emission in Hunan will increase by 120% from 1995 (8.82 mil. ton) to 2020 (19.56 mil. ton), but damage cost will increase by 4.3 times, reaching 6.19 billion RMB in 2020. Results also showed the measures for SO2 control were cost-effective because the marginal damage cost will be about 6000 RMB per ton SO2 in 2020 in BAU case. At current SO2 emission level, marginal benefit will be about 1500 RMB per ton. Uncertainty analysis demonstrated that this model provides reasonable damage estimates and would therefore be applicable in a broad range of policy settings.

Retinal damage caused by air-fluid exchange during pars plana vitrectomy.

PubMed

Yang, Sam S; McDonald, H Richard; Everett, A I; Johnson, Robert N; Jumper, J Michael; Fu, Arthur D

2006-03-01

To report two cases of retinal damage associated with air infusion during pars plana vitrectomy. Observational case report. The authors reviewed the course of two patients who had retinal damage during par plana vitrectomy and air-fluid exchange for the treatment of macular hole and optic pit-related macular detachment, respectively. The intraoperative observations, postoperative course, and outcomes were reported. As a result of high air infusion flow during air-fluid exchange, retinal damage was created in the area contralateral to the infusion port. In Case 1, an oval area of whitening was noted on the first postoperative day. This area subsequently developed into a large retinal break associated with retinal detachment. In the second case, retinal whitening was noted intraoperatively. This region of pallor resolved quickly during the early postoperative period but resulted in a corresponding inferotemporal visual field defect. High infusion flow during air-fluid exchange in eyes undergoing vitrectomy surgery may result in significant retinal damage. This pressure-induced trauma initially causes retinal whitening that may be seen intraoperatively or during the early postoperative period. The region of damaged retina may develop a retinal break and detachment or a corresponding visual field defect.

Safe Surgery Trainer

DTIC Science & Technology

2014-11-15

design, testing, and development. b) Prototype Development – Continue developing SST software, game -flow, and mechanics. Continue developing art...refined learning objectives into measurement outlines. Update IRB submissions, edit usability game play study, and update I/ITSEC IRB. Provide case...minimal or near zero. 9) Related Activities a) Presenting at the Design of Learning Games Community Workshop, at I/ITSEC, Wednesday, Dec 3 rd

[WWW.2CHEAT.COM] Update

ERIC Educational Resources Information Center

Rooks, Clay D.

2006-01-01

This paper is an updated presentation on the subject of cheating and plagiarism via the World Wide Web. In a few hours searching the Internet, the author found even more "cheat" sites than in 1998 that offered not only all types of term and research papers, but college admission letters, reviews, case studies, even dissertations as well. Most now…

Dell Hymes and the New Language Policy Studies: Update from an Underdeveloped Country

ERIC Educational Resources Information Center

McCarty, Teresa L.; Collins, James; Hopson, Rodney K.

2011-01-01

This essay updates Dell Hymes's "Report from an Underdeveloped Country" (the USA), positioning our analysis in the New Language Policy Studies. Taking up Hymes's call for comparative, critical studies of language use, we examine three cases, organizing our analysis around Hymes's questions: What "counts" as a language, a language problem, and…

Assessment Update: Progress, Trends, and Practices in Higher Education. Volume 25, Issue 3, May-June 2013

ERIC Educational Resources Information Center

Banta, Trudy W., Ed.

2013-01-01

This issue of "Assessment Update" presents the following articles: (1) Launching E-Portfolios: An Organic Process; (2) Editor's Notes: Envisioning Learning; (3) Promoting Student Affairs Buy-In for Assessment: Lessons Learned; (4) Working at Assessment; (5) Making the Case for Formative Assessment: How It Improves Student Engagement and…

Designing Adult Learning Strategies: The Case of South Eastern Europe

ERIC Educational Resources Information Center

Gunny, Madeleine; Viertel, Evelyn

2006-01-01

The importance of lifelong learning is generally well understood and few people today would query the need for adults to regularly update their skills in line with labour market needs, and for governments and social partners to provide an environment that supports skills acquisition and updating. However, it is clear when we look at data from the…

A Case Study of Private Schools in Kibera: An Update

ERIC Educational Resources Information Center

Dixon, Pauline; Tooley, James

2012-01-01

This article provides an update on our earlier paper on the introduction by the Kenyan government in 2003 of free primary education (FPE), and its impact on low-fee private schools. First, published papers that have used our contribution as a springboard for discussion are critically reviewed. The argument and supporting evidence that the poor are…

An Update on the "Cycle of Violence." Research in Brief.

ERIC Educational Resources Information Center

Widom, Cathy S.; Maxfield, Michael G.

This brief updates a longitudinal study comparing the arrest records of abused and neglected children with arrest records of non-abused or neglected children. Subjects included 908 substantiated cases of childhood abuse or neglect processed by the courts from 1967-71 who were matched by sex, age, race, and family socioeconomic status with 667…

[Organ damage and cardiorenal syndrome in acute heart failure].

PubMed

Casado Cerrada, Jesús; Pérez Calvo, Juan Ignacio

2014-03-01

Heart failure is a complex syndrome that affects almost all organs and systems of the body. Signs and symptoms of organ dysfunction, in particular kidney dysfunction, may be accentuated or become evident for the first time during acute decompensation of heart failure. Cardiorenal syndrome has been defined as the simultaneous dysfunction of both the heart and the kidney, regardless of which of the two organs may have suffered the initial damage and regardless also of their previous functional status. Research into the mechanisms regulating the complex relationship between the two organs is prompting the search for new biomarkers to help physicians detect renal damage in subclinical stages. Hence, a preventive approach to renal dysfunction may be adopted in the clinical setting in the near future. This article provides a general overview of cardiorenal syndrome and an update of the physiopathological mechanisms involved. Special emphasis is placed on the role of visceral congestion as an emergent mechanism in this syndrome. Copyright © 2014 Elsevier España, S.L. All rights reserved.

Damage prognosis of adhesively-bonded joints in laminated composite structural components of unmanned aerial vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrar, Charles R; Gobbato, Maurizio; Conte, Joel

2009-01-01

The extensive use of lightweight advanced composite materials in unmanned aerial vehicles (UAVs) drastically increases the sensitivity to both fatigue- and impact-induced damage of their critical structural components (e.g., wings and tail stabilizers) during service life. The spar-to-skin adhesive joints are considered one of the most fatigue sensitive subcomponents of a lightweight UAV composite wing with damage progressively evolving from the wing root. This paper presents a comprehensive probabilistic methodology for predicting the remaining service life of adhesively-bonded joints in laminated composite structural components of UAVs. Non-destructive evaluation techniques and Bayesian inference are used to (i) assess the current statemore » of damage of the system and, (ii) update the probability distribution of the damage extent at various locations. A probabilistic model for future loads and a mechanics-based damage model are then used to stochastically propagate damage through the joint. Combined local (e.g., exceedance of a critical damage size) and global (e.g.. flutter instability) failure criteria are finally used to compute the probability of component failure at future times. The applicability and the partial validation of the proposed methodology are then briefly discussed by analyzing the debonding propagation, along a pre-defined adhesive interface, in a simply supported laminated composite beam with solid rectangular cross section, subjected to a concentrated load applied at mid-span. A specially developed Eliler-Bernoulli beam finite element with interlaminar slip along the damageable interface is used in combination with a cohesive zone model to study the fatigue-induced degradation in the adhesive material. The preliminary numerical results presented are promising for the future validation of the methodology.« less

Kinetic Damage from Meteorites

NASA Technical Reports Server (NTRS)

Cooke, William; Brown, Peter; Matney, Mark

2017-01-01

A Near Earth object impacting into Earth's atmosphere may produce damaging effects at the surface due to airblast, thermal pulse, or kinetic impact in the form of meteorites. At large sizes (>many tens of meters), the damage is amplified by the hypersonic impact of these large projectiles moving with cosmic velocity, leaving explosively produced craters. However, much more common is simple "kinetic" damage caused by the impact of smaller meteorites moving at terminal speeds. As of this date a handful of instances are definitively known of people or structures being directly hit and/or damaged by the kinetic impact of meteorites. Meteorites known to have struck humans include the Sylacauga, Alabama fall (1954) and the Mbale meteorite fall (1992). Much more common is kinetic meteorite damage to cars, buildings, and even a post box (Claxton, Georgia - 1984). Historical accounts indicate that direct kinetic damage by meteorites may be more common than recent accounts suggest (Yau et al., 1994). In this talk we will examine the contemporary meteorite flux and estimate the frequency of kinetic damage to various structures, as well as how the meteorite flux might affect the rate of human casualties. This will update an earlier study by Halliday et al (1985), adding variations expected in meteorite flux with latitude (Le Feuvre and Wieczorek, 2008) and validating these model predictions of speed and entry angle with observations from the NASA and SOMN fireball networks. In particular, we explore the physical characteristics of bright meteors which may be used as a diagnostic for estimating which fireballs produce meteorites and hence how early warning of such kinetic damage may be estimated in advance through observations and modelling.

Kinetic Damage from Meteorites

NASA Technical Reports Server (NTRS)

Cooke, William; Brown, Peter; Matney, Mark

2017-01-01

A Near Earth object impacting into Earth's atmosphere may produce damaging effects at the surface due to airblast, thermal pulse, or kinetic impact in the form of meteorites. At large sizes (greater than many tens of meters), the damage is amplified by the hypersonic impact of these large projectiles moving with cosmic velocity, leaving explosively produced craters. However, much more common is simple "kinetic" damage caused by the impact of smaller meteorites moving at terminal speeds. As of this date a handful of instances are definitively known of people or structures being directly hit and/or damaged by the kinetic impact of meteorites. Meteorites known to have struck humans include the Sylacauga, Alabama fall (1954) and the Mbale meteorite fall (1992). Much more common is kinetic meteorite damage to cars, buildings, and even a post box (Claxton, Georgia - 1984). Historical accounts indicate that direct kinetic damage by meteorites may be more common than recent accounts suggest (Yau et al., 1994). In this talk we will examine the contemporary meteorite flux and estimate the frequency of kinetic damage to various structures, as well as how the meteorite flux might affect the rate of human casualties. This will update an earlier study by Halliday et al (1985), adding variations expected in meteorite flux with latitude (Le Feuvre and Wieczorek, 2008) and validating these model predictions of speed and entry angle with observations from the NASA and SOMN fireball networks. In particular, we explore the physical characteristics of bright meteors which may be used as a diagnostic for estimating which fireballs produce meteorites and hence how early warning of such kinetic damage may be estimated in advance through observations and modeling.

Spatial Case Information Management System (SCIMS)

Science.gov Websites

SCIMS facilitates the update of the Land Administration System (LAS) Case File location. Please select Cleanup Notes Utilities LAS Request Import Utility Privacy Copyright System Status Support User Guide

Comparing multistate expected damages, option price and cumulative prospect measures for valuing flood protection

NASA Astrophysics Data System (ADS)

Farrow, Scott; Scott, Michael

2013-05-01

Floods are risky events ranging from small to catastrophic. Although expected flood damages are frequently used for economic policy analysis, alternative measures such as option price (OP) and cumulative prospect value exist. The empirical magnitude of these measures whose theoretical preference is ambiguous is investigated using case study data from Baltimore City. The outcome for the base case OP measure increases mean willingness to pay over the expected damage value by about 3%, a value which is increased with greater risk aversion, reduced by increased wealth, and only slightly altered by higher limits of integration. The base measure based on cumulative prospect theory is about 46% less than expected damages with estimates declining when alternative parameters are used. The method of aggregation is shown to be important in the cumulative prospect case which can lead to an estimate up to 41% larger than expected damages. Expected damages remain a plausible and the most easily computed measure for analysts.

On the computation and updating of the modified Cholesky decomposition of a covariance matrix

NASA Technical Reports Server (NTRS)

Vanrooy, D. L.

1976-01-01

Methods for obtaining and updating the modified Cholesky decomposition (MCD) for the particular case of a covariance matrix when one is given only the original data are described. These methods are the standard method of forming the covariance matrix K then solving for the MCD, L and D (where K=LDLT); a method based on Householder reflections; and lastly, a method employing the composite-t algorithm. For many cases in the analysis of remotely sensed data, the composite-t method is the superior method despite the fact that it is the slowest one, since (1) the relative amount of time computing MCD's is often quite small, (2) the stability properties of it are the best of the three, and (3) it affords an efficient and numerically stable procedure for updating the MCD. The properties of these methods are discussed and FORTRAN programs implementing these algorithms are listed.

Multiple sclerosis epidemiology in Latin America: An updated survey

PubMed Central

Rojas, Juan Ignacio

2017-01-01

Novel epidemiological data have appeared in recent years in Latin America (LATAM). The objective of this study was to perform an updated systematic review of the epidemiology of the disease reported in LATAM. Methods We conducted a systematic review of published epidemiological articles from January 1995 to December 2016. Results Incidence data were found in four studies and ranged from 0.3 to 3 annual cases per 100,000 person-years. Prevalence was reported in 13 studies and ranged from 0.83 to 38.2 cases per 100,000 inhabitants. Two studies showed an increase in prevalence and incidence in the last five years in specific regions. Conclusion The study provides updated information on epidemiological features of MS in the region. The frequency reported is lower compared with some European and North American countries; however, due to recent observations, studies including follow-up assessment of prevalence and incidence should be conducted in the region. PMID:28638628

Updated model assessment of pollution at major U. S. airports

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamartino, R.J.; Rote, D.M.

1979-02-01

The air quality impact of aircraft at and around Los Angeles International Airport (LAX) was simulated for hours of peak aircraft operation and 'worst case' pollutant dispersion conditions by using an updated version of the Argonne Airport Vicinity Air Pollution model; field programs at LAX, O'Hara, and John F. Kennedy International Airports determined the 'worst case' conditions. Maximum carbon monoxide concentrations at LAX were low relative to National Ambient Air Quality Standards; relatively high and widespread hydrocarbon concentrations indicated that aircraft emissions may aggravate oxidant problems near the airport; nitrogen oxide concentrations were close to the levels set in proposedmore » standards. Data on typical time-in-mode for departing and arriving aircraft, the 8/4/77 diurnal variation in airport activity, and carbon monoxide concentration isopleths are given, and the update factors in the model are discussed.« less

Center for Disease Control's Diethylstilbestrol Update: a case for effective operationalization of messaging in social marketing practice.

PubMed

Mattson, Marifran; Basu, Ambar

2010-07-01

The Center for Disease Control's (CDC) Diethylstilbestrol (DES) Update, a campaign to educate people who may have been exposed to the drug DES, is framed on the premises of the social marketing model, namely formative research, audience segmentation, product, price, placement, promotion, and campaign evaluation. More than that, the campaign takes a critical step in extending the social marketing paradigm by highlighting the need to situate the messaging process at the heart of any health communication campaign. This article uses CDC's DES Update as a case study to illustrate an application of a message development tool within social marketing. This tool promotes the operationalization of messaging within health campaigns. Ultimately, the goal of this project is to extend the social marketing model and provide useful theoretical guidance to health campaign practitioners on how to accomplish stellar communication within a social marketing campaign.

Automating the evaluation of flood damages: methodology and potential gains

NASA Astrophysics Data System (ADS)

Eleutério, Julian; Martinez, Edgar Daniel

2010-05-01

The evaluation of flood damage potential consists of three main steps: assessing and processing data, combining data and calculating potential damages. The first step consists of modelling hazard and assessing vulnerability. In general, this step of the evaluation demands more time and investments than the others. The second step of the evaluation consists of combining spatial data on hazard with spatial data on vulnerability. Geographic Information System (GIS) is a fundamental tool in the realization of this step. GIS software allows the simultaneous analysis of spatial and matrix data. The third step of the evaluation consists of calculating potential damages by means of damage-functions or contingent analysis. All steps demand time and expertise. However, the last two steps must be realized several times when comparing different management scenarios. In addition, uncertainty analysis and sensitivity test are made during the second and third steps of the evaluation. The feasibility of these steps could be relevant in the choice of the extent of the evaluation. Low feasibility could lead to choosing not to evaluate uncertainty or to limit the number of scenario comparisons. Several computer models have been developed over time in order to evaluate the flood risk. GIS software is largely used to realise flood risk analysis. The software is used to combine and process different types of data, and to visualise the risk and the evaluation results. The main advantages of using a GIS in these analyses are: the possibility of "easily" realising the analyses several times, in order to compare different scenarios and study uncertainty; the generation of datasets which could be used any time in future to support territorial decision making; the possibility of adding information over time to update the dataset and make other analyses. However, these analyses require personnel specialisation and time. The use of GIS software to evaluate the flood risk requires personnel with a double professional specialisation. The professional should be proficient in GIS software and in flood damage analysis (which is already a multidisciplinary field). Great effort is necessary in order to correctly evaluate flood damages, and the updating and the improvement of the evaluation over time become a difficult task. The automation of this process should bring great advance in flood management studies over time, especially for public utilities. This study has two specific objectives: (1) show the entire process of automation of the second and third steps of flood damage evaluations; and (2) analyse the induced potential gains in terms of time and expertise needed in the analysis. A programming language is used within GIS software in order to automate hazard and vulnerability data combination and potential damages calculation. We discuss the overall process of flood damage evaluation. The main result of this study is a computational tool which allows significant operational gains on flood loss analyses. We quantify these gains by means of a hypothetical example. The tool significantly reduces the time of analysis and the needs for expertise. An indirect gain is that sensitivity and cost-benefit analyses can be more easily realized.

Structures and Materials Experimental Facilities and Capabilities Catalog

NASA Technical Reports Server (NTRS)

Horta, Lucas G. (Compiler); Kurtz-Husch, Jeanette D. (Compiler)

2000-01-01

The NASA Center of Excellent for Structures and Materials at Langley Research Center is responsible for conducting research and developing useable technology in the areas of advanced materials and processing technologies, durability, damage tolerance, structural concepts, advanced sensors, intelligent systems, aircraft ground operations, reliability, prediction tools, performance validation, aeroelastic response, and structural dynamics behavior for aerospace vehicles. Supporting the research activities is a complementary set of facilities and capabilities documented in this report. Because of the volume of information, the information collected was restricted in most cases to one page. Specific questions from potential customers or partners should be directed to the points of contacts provided with the various capabilities. Grouping of the equipment is by location as opposed to function. Geographical information of the various buildings housing the equipment is also provided. Since this is the first time that such an inventory is ever collected at Langley it is by no means complete. It is estimated that over 90 percent of the equipment capabilities at hand are included but equipment is continuously being updated and will be reported in the future.

What is new in the management of rapidly progressive glomerulonephritis?

PubMed Central

Greenhall, George H.B.; Salama, Alan D.

2015-01-01

Rapidly progressive glomerulonephritis (RPGN) results from severe crescentic damage to glomeruli and leads to irreversible kidney failure if not diagnosed and managed in a timely fashion. Traditional treatment has relied on glucocorticoids and cyclophosphamide, with additional plasmapheresis for certain conditions. Here we describe updates in the management of RPGN, according to the underlying renal pathology. However, there remains a paucity of trials that have enrolled patients with more advanced renal disease, dialysis dependence or with RPGN, and we are therefore still reliant on extrapolation of data from studies of patients with a less severe form of disease. In addition, reporting bias results in publication of cases or cohorts showing benefit for newer agents in advanced disease or RPGN, but it remains unclear how many unsuccessful outcomes in these circumstances take place. Since clinical trials specifically in RPGN are unlikely, use of biologic registries or combination of sufficient sized cohort series may provide indications of benefit outside of a clinical trial setting and should be encouraged, in order to provide some evidence for the efficacy of therapeutic regimens in RPGN and advanced renal disease. PMID:25815169

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

Friedman, Paul; Beck, Ronna Lee

Included in the report are summaries of four new cases and updated information on 38 cases regarding legal issues in mental retardation. Featured is a review of cases dealing with liability of judges and lawyers in violating the rights of mentally retarded persons. Other issues addressed (with sample court case in parentheses) include commitment…

Physicians’ duty to recontact and update genetic advice

PubMed Central

Stevens, Yvonne A; Senner, Grant D; Marchant, Gary E

2017-01-01

This perspective addresses whether physicians have a duty to recontact former or current patients to update clinical advice based on newly discovered genomic information. Genetic information is unique compared with other medical data in that the underlying data do not appreciably change during the patients’ lifetime, but the clinical significance of that information will continue to evolve. Based on relevant case law and guidelines, there is no general, established legal duty for physicians to affirmatively recontact former or current patients to update clinical advice based on newly discovered genetic information. However, integration of genomics into clinical practice is advancing quickly, and there may be limited, specific situations where a physician may have a duty to provide updated genetic information. PMID:29158769

Introducing GEOPHIRES v2.0: Updated Geothermal Techno-Economic Simulation Tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckers, Koenraad J; McCabe, Kevin

This paper presents an updated version of the geothermal techno-economic simulation tool GEOPHIRES (GEOthermal energy for Production of Heat and electricity ('IR') Economically Simulated). GEOPHIRES combines engineering models of the reservoir, wellbores, and surface plant facilities of a geothermal plant with an economic model to estimate the capital and operation and maintenance costs, lifetime energy production, and overall levelized cost of energy. The available end-use options are electricity, direct-use heat, and cogeneration. The main updates in the new version include conversion of the source code from FORTRAN to Python, the option to import temperature data (e.g., measured or from stand-alonemore » reservoir simulator), updated cost correlations, and more flexibility in selecting the time step and number of injection and production wells. In this paper, we provide an overview of all the updates and two case studies to illustrate the tool's new capabilities.« less

75 FR 53643 - Examination Guidelines Update: Developments in the Obviousness Inquiry After KSR v.Teleflex

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

...The United States Patent and Trademark Office (USPTO or Office) is issuing an update (2010 KSR Guidelines Update) to its obviousness guidelines for its personnel to be used when applying the law of obviousness under 35 U.S.C. 103. This 2010 KSR Guidelines Update highlights case law developments on obviousness under 35 U.S.C. 103 since the 2007 decision by the United States Supreme Court (Supreme Court) in KSR Int'l Co. v. Teleflex Inc. These guidelines are intended to be used by Office personnel in conjunction with the guidance in the Manual of Patent Examining Procedure when applying the law of obviousness under 35 U.S.C. 103. Members of the public are invited to provide comments on the 2010 KSR Guidelines Update. The Office is especially interested in receiving suggestions of recent decisional law in the field of obviousness that would have particular value as teaching tools.

Model Updating of Complex Structures Using the Combination of Component Mode Synthesis and Kriging Predictor

PubMed Central

Li, Yan; Wang, Dejun; Zhang, Shaoyi

2014-01-01

Updating the structural model of complex structures is time-consuming due to the large size of the finite element model (FEM). Using conventional methods for these cases is computationally expensive or even impossible. A two-level method, which combined the Kriging predictor and the component mode synthesis (CMS) technique, was proposed to ensure the successful implementing of FEM updating of large-scale structures. In the first level, the CMS was applied to build a reasonable condensed FEM of complex structures. In the second level, the Kriging predictor that was deemed as a surrogate FEM in structural dynamics was generated based on the condensed FEM. Some key issues of the application of the metamodel (surrogate FEM) to FEM updating were also discussed. Finally, the effectiveness of the proposed method was demonstrated by updating the FEM of a real arch bridge with the measured modal parameters. PMID:24634612

The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017.

PubMed

Neal, Joseph M; Barrington, Michael J; Fettiplace, Michael R; Gitman, Marina; Memtsoudis, Stavros G; Mörwald, Eva E; Rubin, Daniel S; Weinberg, Guy

2018-02-01

The American Society of Regional Anesthesia and Pain Medicine's Third Practice Advisory on local anesthetic systemic toxicity is an interim update from its 2010 advisory. The advisory focuses on new information regarding the mechanisms of lipid resuscitation, updated frequency estimates, the preventative role of ultrasound guidance, changes to case presentation patterns, and limited information related to local infiltration anesthesia and liposomal bupivacaine. In addition to emerging information, the advisory updates recommendations pertaining to prevention, recognition, and treatment of local anesthetic systemic toxicity. WHAT'S NEW IN THIS UPDATE?: This interim update summarizes recent scientific findings that have enhanced our understanding of the mechanisms that lead to lipid emulsion reversal of LAST, including rapid partitioning, direct inotropy, and post-conditioning. Since the previous practice advisory, epidemiological data have emerged that suggest a lower frequency of LAST as reported by single institutions and some registries, nevertheless a considerable number of events still occur within the general community. Contemporary case reports suggest a trend toward delayed presentation, which may mirror the increased use of ultrasound guidance (fewer intravascular injections), local infiltration techniques (slower systemic uptake), and continuous local anesthetic infusions. Small patient size and sarcopenia are additional factors that increase potential risk for LAST. An increasing number of reported events occur outside of the traditional hospital setting and involve non-anesthesiologists.

Modifications of natural hazard impacts and hydrological extremes in previous centuries (Southern Italy)

NASA Astrophysics Data System (ADS)

Petrucci, Olga; Pasqua, Aurora Angela; Polemio, Maurizio

2013-04-01

The present work is based on the use of a wide historical database concerning floods and landslides which occurred in Calabria, a region of southern Italy, since the seventeenth century, and including more than 11,000 records. This database has been built by collecting data coming from different information sources as newspapers, archives of regional and national agencies, scientific and technical reports, on-site surveys reports and information collected by interviewing both people involved and local administrators. This database has been continuously updated by both the results of local historical research and data coming from the daily survey of regional newspapers. Similarly, a wide archive of rainfall data for the same period and the same region has been implemented. In this work, basing on the abovementioned archives, a comparative analysis of floods that occurred in a regional sector over a long period and the climatic data characterizing the same period has been carried out, focusing on the climate trend and aiming to investigate the potential effect of climate variation on the damaging floods trend. The aim was to assess whether the frequency of floods is changing and, if so, whether these changes can be related to either rainfall and/or anthropogenic modifications. In order to assess anthropogenic modifications, the evolution of urbanized sectors of the study area in the last centuries has been reenacted by mean of comparisons, in GIS environment, of historical maps of different epochs. The annual variability of rainfall was discussed using an annual index. Short duration-high intensity rainfalls were characterized considering time series of annual maxima of 1, 3, 6, 12, and 24 hours and daily rainfall. The analysis indicates that, despite a rainfall trend favorable towards a reduction in flood occurrence, floods damage has not decreased. This seems to be mainly the effect of mismanagement of land use modifications. Moreover, the long historical series analyzed allowed us to individuate both the most frequently damaged elements and the frequently damaged geographical sectors of the study area, even with a further in depth on the cases involving people in urbanized sectors.

Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases.

PubMed

Acheampong, Paul; Thomas, Simon H L

2016-10-01

To evaluate the role of reported daily dose, age and other risk factors, and to assess the value of quantifying serum transaminase activity and paracetamol (acetaminophen) concentration at initial assessment for identifying patients at risk of hepatotoxicity following repeated supratherapeutic paracetamol ingestion (RSPI). Systematic literature review with collation and analysis of individual-level data from reported cases of RSPI associated with liver damage. In 199 cases meeting the selection criteria, severe liver damage (ALT/AST ≥1000 IU l(-1) , liver failure or death) was reported in 186 (93%) cases including 77/78 (99%) children aged ≤6 years. Liver failure occurred in 127 (64%) cases; of these 49 (39%) died. Maximum ingested daily paracetamol doses were above UK recommendations in 143 (72%) patients. US-Australasian thresholds for repeated supratherapeutic ingestions requiring intervention were not met in 71 (36%) cases; of these 35 (49%) developed liver failure and 10 (14%) died. No cases developing liver damage had paracetamol concentration < 20 mg l(-1) and a normal ALT/AST on initial presentation or when RSPI was first suspected, but both of these values were only available for 79 (40%) cases. Severe liver damage is reported after RSPI in adults and children, sometimes involving reported doses below current thresholds for intervention. Paracetamol concentrations <20 mg l(-1) with normal serum ALT/AST activity on initial assessment suggests a low risk of subsequent liver damage. These findings are, however, limited by low patient numbers, publication bias and the accuracy of the histories in reported cases. © 2016 The British Pharmacological Society.

Courtside: A Damaging Lesson

ERIC Educational Resources Information Center

Zirkel, Perry A.

2004-01-01

This case presents a costly lesson for teachers and for districts that include a liquidated, or stipulated, damages clause in their teacher employment contracts. Although the court enforced the clause in this case, in this well-reasoned recent decision and in most of the much older, canvassed case law from other jurisdictions, the answer to the…

The Anatomy of Amnesia: Neurohistological Analysis of Three New Cases

ERIC Educational Resources Information Center

Gold, Jeffrey J.; Squire, Larry R.

2006-01-01

The most useful information about the anatomy of human memory comes from cases where there has been extensive neuropsychological testing followed by detailed post-mortem neurohistological analysis. To our knowledge, only eight such cases have been reported (four with medial temporal lobe damage and four with diencephalic damage). Here we present…

Medicare and Medicaid Programs; CY 2018 Home Health Prospective Payment System Rate Update and CY 2019 Case-Mix Adjustment Methodology Refinements; Home Health Value-Based Purchasing Model; and Home Health Quality Reporting Requirements. Final rule.

PubMed

2017-11-07

This final rule updates the home health prospective payment system (HH PPS) payment rates, including the national, standardized 60-day episode payment rates, the national per-visit rates, and the non-routine medical supply (NRS) conversion factor, effective for home health episodes of care ending on or after January 1, 2018. This rule also: Updates the HH PPS case-mix weights using the most current, complete data available at the time of rulemaking; implements the third year of a 3-year phase-in of a reduction to the national, standardized 60-day episode payment to account for estimated case-mix growth unrelated to increases in patient acuity (that is, nominal case-mix growth) between calendar year (CY) 2012 and CY 2014; and discusses our efforts to monitor the potential impacts of the rebasing adjustments that were implemented in CY 2014 through CY 2017. In addition, this rule finalizes changes to the Home Health Value-Based Purchasing (HHVBP) Model and to the Home Health Quality Reporting Program (HH QRP). We are not finalizing the implementation of the Home Health Groupings Model (HHGM) in this final rule.

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

Friedman, Paul, Ed.; Beck, Ronna Lee, Ed.

Included in the booklet on mental retardation and the law are reports on 11 new court cases and updated information on 35 court cases reported in previous issues. Court cases cover the following issues: architectural barriers, commitment, criminal law, education, employment, guardianship, protection from harm, sterilization, treatment, and zoning.…

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

President's Committee on Mental Retardation, Washington, DC.

Featured in the issue is an analysis of the consent Decree in New York State Association for Retarded Children v. Carey (Willowbrook case). In addition, summaries and updated information are presented for 25 new cases and 34 cases previously reported regarding the following topics: architectural barriers, classification, commitment, custody,…

Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update.

PubMed

Tomaszewski, Dariusz

2015-01-01

The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients varies from 16% to 45%, although it can be as high as 72%. As a consequence, the hospitalization time of patients who developed POCD was longer, the outcome and quality of life were worsened, and prolonged medical and social assistance were necessary. In this review the short description of such biomarkers of brain damage as the S100B protein, NSE, GFAP, Tau protein, metalloproteinases, ubiquitin C terminal hydrolase, microtubule-associated protein, myelin basic protein, α-II spectrin breakdown products, and microRNA was made. The role of thromboembolic material in the development of cognitive decline was also discussed. Special attention was paid to optimization of surgical and anesthetic procedures in the prevention of postoperative cognitive decline.

The Maintenance of Mitochondrial DNA Integrity—Critical Analysis and Update

PubMed Central

Alexeyev, Mikhail; Shokolenko, Inna; Wilson, Glenn; LeDoux, Susan

2013-01-01

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are constantly damaged by noxious agents. Eukaryotic cells have developed efficient mechanisms to deal with this assault. The process of DNA repair in mitochondria, initially believed nonexistent, has now evolved into a mature area of research. In recent years, it has become increasingly appreciated that mitochondria possess many of the same DNA repair pathways that the nucleus does. Moreover, a unique pathway that is enabled by high redundancy of the mitochondrial DNA and allows for the disposal of damaged DNA molecules operates in this organelle. In this review, we attempt to present a unified view of our current understanding of the process of DNA repair in mitochondria with an emphasis on issues that appear controversial. PMID:23637283

STS-121: Discovery Pre-Launch Mission Management Team Press Briefing

NASA Technical Reports Server (NTRS)

2006-01-01

The briefing began with Allard Buetel (NASA Public Affairs) introducing Bill Gerstenmaier (Associate Administrator for Space Operations) who provided an update of the Mission Management team meeting. The 3 criteria reviewed by the team were: a) ascent heating; b) ice formation and c) remaining foam still intact. The ascent heating had a safety factor of 5 and posed no concern. Ice formation was not a concern. In order to insure there was no damage to the remaining foam, an 8ft. pipe with a camera attached was used to provide pictures. The boroscope pictures showed there was no damage to the brackets or foam. The inspection went very well and the foam was acceptable and ready to fly. Then the floor was open to questions from the press.

Current concepts in the management of hidradenitis suppurativa in children.

PubMed

Danby, F William

2015-08-01

This review is intended to provide the background aetiopathogenetic framework upon which management of this disorder can be based, particularly with relation to new concepts of the pathogenesis of the disorder. The emphasis is on the prevention of the disorder's full expression by addressing the metabolic changes that drive the underlying structural damage and the immune system's subsequent reaction to this damage. The mechanism by which dietary factors impact on this disease are elucidated, the anatomic defect suspected to be responsible for the disorder is introduced, and an updated flow sheet describing and linking the clinicopathological changes recently described are provided. Recent work in the understanding of the induction and evolution of the lesions provides a background upon which the preventive regimen and both the medical and surgical approaches can be effectively based.

[Orbitofrontal cortex and morality].

PubMed

Funayama, Michitaka; Mimura, Masaru

2012-10-01

Research on the neural substrates of morality is a recently emerging field in neuroscience. The anatomical structures implicated to play a role in morality include the frontal lobe, temporal lobe, cingulate gyrus, amygdala, hippocampus, and basal ganglia. In particular, the orbitofrontal or ventromedial prefrontal areas are thought to be involved in decision-making, and damage to these areas is likely to cause decision-making deficits and/or problems in impulsive control, which may lead to antisocial and less moral behaviors. In this article, we focus on case presentation and theory development with regard to moral judgment. First, we discuss notable cases and syndromes developing after orbitofrontal/ventromedial prefrontal damage, such as the famous cases of Gage and EVR, cases of childhood orbitofrontal damage, forced collectionism, squalor syndrome, and hypermoral syndrome. We then review the proposed theories and neuropsychological mechanisms underlying decision-making deficits following orbitofrontal/ventromedial prefrontal damage, including the somatic-marker hypothesis, reversal learning, preference judgment, theory of mind, and moral dilemma.

Update on Photoprotection

PubMed Central

Rai, Reena; Shanmuga, Sekar C; Srinivas, CR

2012-01-01

Photoprotection by sunscreens, clothing and glasses are important to protect the skin against the detrimental effects of sun exposure. In order to achieve complete protection, topical strategies must shield against the range of solar wavelengths ultraviolet A, ultraviolet B, infrared radiation that can damage the skin. To provide the necessary broad spectrum coverage, combinations of chemical and physical UV filters along with molecules that are capable of interfering with and/or preventing the deleterious effects of sunlight are discussed in this review. PMID:23112351

Optimal Artificial Boundary Condition Configurations for Sensitivity-Based Model Updating and Damage Detection

DTIC Science & Technology

2010-09-01

matrix is used in many methods, like Jacobi or Gauss Seidel , for solving linear systems. Also, no partial pivoting is necessary for a strictly column...problems that arise during the procedure, which in general, converges to the solving of a linear system. The most common issue with the solution is the... iterative procedure to find an appropriate subset of parameters that produce an optimal solution commonly known as forward selection. Then, the

The Deceit Continues: An Updated Literature Review of Munchausen Syndrome By Proxy.

ERIC Educational Resources Information Center

Sheridan, Mary S.

2003-01-01

This updated review of the literature on Munchausen Syndrome by Proxy (MBSP) analyzes 451 cases from 154 medical and psychosocial journal articles. Typical victims were usually 4 years of age or under; 6% were dead, and 7.3% suffered long-term or permanent injury. Twenty-five percent of siblings were dead. Mothers were perpetrators in 76.5% of…

An adverse event of suprapubic catheter SPC insertion. A call for updating the existing guidelines.

PubMed

Jalil, Rozh; Mukundan, Chandrika; Bhatti, Tahir S

2012-11-15

The suprapubic catheter (SPC) is a useful and widely used tool in urological practice. However, complications can arise from its insertion or ongoing care. We add to the literature a case of an adverse event of its insertion where it has gone through a vascular graft and recommending updating the SPC insertion guidelines.

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

PubMed Central

2013-01-01

Abstract An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity is reviewed. Key aspects of the theory are emphasized. Another main focus concerns common misconceptions that can mislead investigators from other specialties, even to wrongly discard the theory. Those different issues include (i) the main reactive oxygen species (ROS)-generating site in the respiratory chain in relation to aging and longevity: complex I; (ii) the close vicinity or even contact between that site and the mitochondrial DNA, in relation to the lack of local efficacy of antioxidants and to sub-cellular compartmentation; (iii) the relationship between mitochondrial ROS production and oxygen consumption; (iv) recent criticisms on the MFRTA; (v) the widespread assumption that ROS are simple “by-products” of the mitochondrial respiratory chain; (vi) the unnecessary postulation of “vicious cycle” hypotheses of mitochondrial ROS generation which are not central to the free radical theory of aging; and (vii) the role of DNA repair concerning endogenous versus exogenous damage. After considering the large body of data already available, two general characteristics responsible for the high maintenance degree of long-lived animals emerge: (i) a low generation rate of endogenous damage: and (ii) the possession of tissue macromolecules that are highly resistant to oxidative modification. Antioxid. Redox Signal. 19, 1420–1445. PMID:23642158

Clothing damage analysis in alleged sexual assaults--the need for a systematic approach.

PubMed

Boland, C A; McDermott, S D; Ryan, J

2007-04-11

Clothing damage analysis is an integral part of the examinations carried out in sexual assault type cases. This analysis can be used to corroborate different versions of events and is at its most powerful in elucidating false allegation cases and consent cases. The purpose of this study was to determine to what extent people with varying levels of forensic awareness, experience and training could correctly carry out damage analysis. Two participant groups were asked to take part in this study. Group A ('forensic group') comprised participants at a forensic science conference, and Group B ('student group') comprised students undertaking a degree course in Forensic Science. Each group was given a practical workshop consisting of a lecture outlining common fabric types and general features observed in different damage types. Each participant was subsequently shown 25 pieces of 'damage' and asked to identify both the type of fabric construction (knit or weave) and the type of damage (cut, tear, rip, wear and tear). The ability to identify fabric construction and damage types varied within the two groups studied and across the groups. The forensic group performed better both in fabric and damage assessment than the student group. This paper suggests a systematic approach to clothing damage analysis to maximise the benefits that can be obtained from this area of forensic science and to minimise the subjectivity within the field.

Computer-assisted expert case definition in electronic health records.

PubMed

Walker, Alexander M; Zhou, Xiaofeng; Ananthakrishnan, Ashwin N; Weiss, Lisa S; Shen, Rongjun; Sobel, Rachel E; Bate, Andrew; Reynolds, Robert F

2016-02-01

To describe how computer-assisted presentation of case data can lead experts to infer machine-implementable rules for case definition in electronic health records. As an illustration the technique has been applied to obtain a definition of acute liver dysfunction (ALD) in persons with inflammatory bowel disease (IBD). The technique consists of repeatedly sampling new batches of case candidates from an enriched pool of persons meeting presumed minimal inclusion criteria, classifying the candidates by a machine-implementable candidate rule and by a human expert, and then updating the rule so that it captures new distinctions introduced by the expert. Iteration continues until an update results in an acceptably small number of changes to form a final case definition. The technique was applied to structured data and terms derived by natural language processing from text records in 29,336 adults with IBD. Over three rounds the technique led to rules with increasing predictive value, as the experts identified exceptions, and increasing sensitivity, as the experts identified missing inclusion criteria. In the final rule inclusion and exclusion terms were often keyed to an ALD onset date. When compared against clinical review in an independent test round, the derived final case definition had a sensitivity of 92% and a positive predictive value of 79%. An iterative technique of machine-supported expert review can yield a case definition that accommodates available data, incorporates pre-existing medical knowledge, is transparent and is open to continuous improvement. The expert updates to rules may be informative in themselves. In this limited setting, the final case definition for ALD performed better than previous, published attempts using expert definitions. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

ACHP | Working with Section 106

Science.gov Websites

Federal Review webpage. State-by-State List of ACHP Signed Agreement Documents In hundreds of cases cases. Use the OFAP Agency Organizational Chart to identify the appropriate OFAP contact for assistance of federal historic preservation cases Updated February 13, 2018 Return to Top

Study flow diagrams in Cochrane systematic review updates: an adapted PRISMA flow diagram.

PubMed

Stovold, Elizabeth; Beecher, Deirdre; Foxlee, Ruth; Noel-Storr, Anna

2014-05-29

Cochrane systematic reviews are conducted and reported according to rigorous standards. A study flow diagram must be included in a new review, and there is clear guidance from the PRISMA statement on how to do this. However, for a review update, there is currently no guidance on how study flow diagrams should be presented. To address this, a working group was formed to find a solution and produce guidance on how to use these diagrams in review updates.A number of different options were devised for how these flow diagrams could be used in review updates, and also in cases where multiple searches for a review or review update have been conducted. These options were circulated to the Cochrane information specialist community for consultation and feedback. Following the consultation period, the working group refined the guidance and made the recommendation that for review updates an adapted PRISMA flow diagram should be used, which includes an additional box with the number of previously included studies feeding into the total. Where multiple searches have been conducted, the results should be added together and treated as one set of results.There is no existing guidance for using study flow diagrams in review updates. Our adapted diagram is a simple and pragmatic solution for showing the flow of studies in review updates.

Field operating experience in locating and re-recovering landslide-damaged oil wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, R.J.

1974-01-01

Landslides have damaged 65 oil wells on Getty Oil Co.'s leases in the Ventura Avenue field. During a landslide, some wells may remain connected to the surface while other wells may be buried. Well damage ranges from slight bending to complete severing of all casing strings, and depth of damage varies from 15 to 120 ft. Two major problems have been encountered when repair work is planned for a landslide damaged well. The first problem is to locate the undamaged well casing below the landslide. The second problem is to recover the well and replace the damaged casing. Some methodsmore » used by Getty Oil Co. to locate the undamaged portion of a well are conventional surveys, dipneedle surveys, magnetometer surveys, kink-meter surveys, and test holes. Three methods have been used to recover landslide damaged wells in the Ventura Avenue field. The simplest method is an open excavation made with standard earthmoving equipment. This method is limited to shallow depths and locations where the landslide would not be reactivated. To reach greater depths, special methods such as hand-dug or machine-dug shafts must be used. All 3 methods have been used successfully by Getty Oil Co.« less

On-line Bayesian model updating for structural health monitoring

NASA Astrophysics Data System (ADS)

Rocchetta, Roberto; Broggi, Matteo; Huchet, Quentin; Patelli, Edoardo

2018-03-01

Fatigue induced cracks is a dangerous failure mechanism which affects mechanical components subject to alternating load cycles. System health monitoring should be adopted to identify cracks which can jeopardise the structure. Real-time damage detection may fail in the identification of the cracks due to different sources of uncertainty which have been poorly assessed or even fully neglected. In this paper, a novel efficient and robust procedure is used for the detection of cracks locations and lengths in mechanical components. A Bayesian model updating framework is employed, which allows accounting for relevant sources of uncertainty. The idea underpinning the approach is to identify the most probable crack consistent with the experimental measurements. To tackle the computational cost of the Bayesian approach an emulator is adopted for replacing the computationally costly Finite Element model. To improve the overall robustness of the procedure, different numerical likelihoods, measurement noises and imprecision in the value of model parameters are analysed and their effects quantified. The accuracy of the stochastic updating and the efficiency of the numerical procedure are discussed. An experimental aluminium frame and on a numerical model of a typical car suspension arm are used to demonstrate the applicability of the approach.

Game-Theoretic Models of Information Overload in Social Networks

NASA Astrophysics Data System (ADS)

Borgs, Christian; Chayes, Jennifer; Karrer, Brian; Meeder, Brendan; Ravi, R.; Reagans, Ray; Sayedi, Amin

We study the effect of information overload on user engagement in an asymmetric social network like Twitter. We introduce simple game-theoretic models that capture rate competition between celebrities producing updates in such networks where users non-strategically choose a subset of celebrities to follow based on the utility derived from high quality updates as well as disutility derived from having to wade through too many updates. Our two variants model the two behaviors of users dropping some potential connections (followership model) or leaving the network altogether (engagement model). We show that under a simple formulation of celebrity rate competition, there is no pure strategy Nash equilibrium under the first model. We then identify special cases in both models when pure rate equilibria exist for the celebrities: For the followership model, we show existence of a pure rate equilibrium when there is a global ranking of the celebrities in terms of the quality of their updates to users. This result also generalizes to the case when there is a partial order consistent with all the linear orders of the celebrities based on their qualities to the users. Furthermore, these equilibria can be computed in polynomial time. For the engagement model, pure rate equilibria exist when all users are interested in the same number of celebrities, or when they are interested in at most two. Finally, we also give a finite though inefficient procedure to determine if pure equilibria exist in the general case of the followership model.

Is 30-second update fast enough for convection-resolving data assimilation?

NASA Astrophysics Data System (ADS)

Miyoshi, Takemasa; Ruiz, Juan; Lien, Guo-Yuan; Teramura, Toshiki; Kondo, Keiichi; Maejima, Yasumitsu; Honda, Takumi; Otsuka, Shigenori

2017-04-01

For local severe weather forecasting at 100-m resolution with 30-minute lead time, we have been working on the "Big Data Assimilation" (BDA) effort for super-rapid 30-second cycle of an ensemble Kalman filter. We have presented two papers with the concept and case studies (Miyoshi et al. 2016, BAMS; Proceedings of the IEEE). We focus on the non-Gaussian PDF in this study. We were hoping that we could assume the Gaussian error distribution in 30-second forecasts before strong nonlinear dynamics distort the error distribution for rapidly-changing convective storms. However, using 1000 ensemble members, the reduced-resolution version of the BDA system at 1-km grid spacing with 30-second updates showed ubiquity of highly non-Gaussian PDF. Although our results so far with multiple case studies were quite successful, this gives us a doubt about our Gaussian assumption even if the data assimilation interval is short enough compared with the system's chaotic time scale. We therefore pose a question if the 30-second update is fast enough for convection-resolving data assimilation under the Gaussian assumption. To answer this question, we aim to gain combined knowledge from BDA case studies, 1000-member experiments, 30-second breeding experiments, and toy-model experiments with dense and frequent observations. In this presentation, we will show the most up-to-date results of the BDA research, and will discuss about the question if the 30-second update is fast enough for convective-scale data assimilation.

Damage mechanisms of MoN/SiN multilayer optics for next-generation pulsed XUV light sources.

PubMed

Sobierajski, R; Bruijn, S; Khorsand, A R; Louis, E; van de Kruijs, R W E; Burian, T; Chalupsky, J; Cihelka, J; Gleeson, A; Grzonka, J; Gullikson, E M; Hajkova, V; Hau-Riege, S; Juha, L; Jurek, M; Klinger, D; Krzywinski, J; London, R; Pelka, J B; Płociński, T; Rasiński, M; Tiedtke, K; Toleikis, S; Vysin, L; Wabnitz, H; Bijkerk, F

2011-01-03

We investigated the damage mechanism of MoN/SiN multilayer XUV optics under two extreme conditions: thermal annealing and irradiation with single shot intense XUV pulses from the free-electron laser facility in Hamburg - FLASH. The damage was studied "post-mortem" by means of X-ray diffraction, interference-polarizing optical microscopy, atomic force microscopy, and scanning transmission electron microscopy. Although the timescale of the damage processes and the damage threshold temperatures were different (in the case of annealing it was the dissociation temperature of Mo2N and in the case of XUV irradiation it was the melting temperature of MoN) the main damage mechanism is very similar: molecular dissociation and the formation of N2, leading to bubbles inside the multilayer structure.

Mental Retardation and the Law: A Report on Status of Current Court Cases, December 1975.

ERIC Educational Resources Information Center

Friedman, Paul R.; Beck, Ronna Lee

Reported are seven new court cases and updated information on 39 previously reported cases regarding the legal rights of the retarded. Analyzed are cases on the following topics (with sample cases in parentheses): classification (Steward, et. al. v. Philips, et al.); commitment (Pate v. Parham and White v. Director of Michigan Department of Mental…

Update on the Status of the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope

NASA Astrophysics Data System (ADS)

Hernandez, Svea; Aloisi, A.; Bostroem, K. A.; Cox, C.; Debes, J. H.; DiFelice, A.; Roman-Duval, J.; Hodge, P.; Holland, S.; Lindsay, K.; Lockwood, S. A.; Mason, E.; Oliveira, C. M.; Penton, S. V.; Proffitt, C. R.; Sonnentrucker, P.; Taylor, J. M.; Wheeler, T.

2013-06-01

The Space Telescope Imaging Spectrograph (STIS) has been on orbit for approximately 16 years as one of the 2nd generation instruments on the Hubble Space Telescope (HST). Its operations were interrupted by an electronics failure in 2004, but STIS was successfully repaired in May 2009 during Service Mission 4 (SM4) allowing it to resume science observations. The Instrument team continues to monitor its performance and work towards improving the quality of its products. Here we present updated information on the status of the FUV and NUV MAMA and the CCD detectors onboard STIS and describe recent changes to the STIS calibration pipeline. We also discuss the status of efforts to apply a pixel-based correction for charge transfer inefficiency (CTI) effects to STIS CCD data. These techniques show promise for ameliorating the effects of ongoing radiation damage on the quality of STIS CCD data.

Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner

PubMed Central

Gergianaki, Irini; Bertsias, George

2018-01-01

Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that manifests a wide range of organ involvement. Traditionally, the diagnosis and management of SLE is provided at secondary and tertiary centers to ensure prompt initiation of treatment, adequate control of flares and prevention of irreversible organ damage. Notwithstanding, the role of primary care in SLE is also emerging as there are still significant unmet needs such as the diagnostic delay at the community level and the high burden of therapy- and disease-related comorbidities. In the present review, we summarize practical messages for primary care physicians and general practitioners (GPs) concerning early diagnosis and proper referral of patients with SLE. In addition, we discuss the main comorbidities complicating the disease course and the recommended preventative measures, and we also provide an update on the role and current educational needs of GPs regarding the disease. PMID:29896474

Advanced Mitigation Process (AMP) for Improving Laser Damage Threshold of Fused Silica Optics

NASA Astrophysics Data System (ADS)

Ye, Xin; Huang, Jin; Liu, Hongjie; Geng, Feng; Sun, Laixi; Jiang, Xiaodong; Wu, Weidong; Qiao, Liang; Zu, Xiaotao; Zheng, Wanguo

2016-08-01

The laser damage precursors in subsurface of fused silica (e.g. photosensitive impurities, scratches and redeposited silica compounds) were mitigated by mineral acid leaching and HF etching with multi-frequency ultrasonic agitation, respectively. The comparison of scratches morphology after static etching and high-frequency ultrasonic agitation etching was devoted in our case. And comparison of laser induce damage resistance of scratched and non-scratched fused silica surfaces after HF etching with high-frequency ultrasonic agitation were also investigated in this study. The global laser induce damage resistance was increased significantly after the laser damage precursors were mitigated in this case. The redeposition of reaction produce was avoided by involving multi-frequency ultrasonic and chemical leaching process. These methods made the increase of laser damage threshold more stable. In addition, there is no scratch related damage initiations found on the samples which were treated by Advanced Mitigation Process.

Impact damage and residual tension strength of a thick graphite/epoxy rocket motor case

NASA Technical Reports Server (NTRS)

Poe, C. C., Jr.

1992-01-01

Impacters of various masses were dropped from various heights onto thick graphite/epoxy filament-wound cylinders. The cylinders represented filament-wound cases made for the booster motors of the Space Shuttle. Tups of various shapes were affixed to the impacters. Some of the cylinders were filled with inert propellant, and some were empty. The cylinders were impacted numerous times around the circumference and then cut into tension coupons, each containing an impact site. The size of the damage and the residual tension strength were measured. For hemispherical tups, strength was reduced as much as 30 percent by nonvisible damage. The damage consisted of matrix cracking and broken fibers. Analytical methods were used to predict the damage and residual tension strength. A factor of safety to account for nonvisible damage was determined. For corner and rod shaped tups, any damage that resulted in strength loss was readily visible.

Advanced Mitigation Process (AMP) for Improving Laser Damage Threshold of Fused Silica Optics

PubMed Central

Ye, Xin; Huang, Jin; Liu, Hongjie; Geng, Feng; Sun, Laixi; Jiang, Xiaodong; Wu, Weidong; Qiao, Liang; Zu, Xiaotao; Zheng, Wanguo

2016-01-01

The laser damage precursors in subsurface of fused silica (e.g. photosensitive impurities, scratches and redeposited silica compounds) were mitigated by mineral acid leaching and HF etching with multi-frequency ultrasonic agitation, respectively. The comparison of scratches morphology after static etching and high-frequency ultrasonic agitation etching was devoted in our case. And comparison of laser induce damage resistance of scratched and non-scratched fused silica surfaces after HF etching with high-frequency ultrasonic agitation were also investigated in this study. The global laser induce damage resistance was increased significantly after the laser damage precursors were mitigated in this case. The redeposition of reaction produce was avoided by involving multi-frequency ultrasonic and chemical leaching process. These methods made the increase of laser damage threshold more stable. In addition, there is no scratch related damage initiations found on the samples which were treated by Advanced Mitigation Process. PMID:27484188

Assessment of infrastructure functional damages caused by natural-technological disasters

NASA Astrophysics Data System (ADS)

Massabò, Marco; Trasforini, Eva; Traverso, Stefania; Rudari, Roberto; De Angeli, Silvia; Cecinati, Francesca; Cerruti, Valentina

2013-04-01

The assessment of infrastructure damages caused by technological disaster poses several challenges, from gathering needed information on the territorial system to the definition of functionality curves for infrastructures elements (such as, buildings, road school) that are exposed to both natural and technological event. Moreover, areas affected by natural or natech (technological disasters triggered by natural events) disasters have often very large extensions and a rapid survey of them to gather all the needed information is a very difficult task, for many reasons, not least the difficult access to the existing databases and resources. We use multispectral optical imagery with other geographical and unconventional data to identify and characterize exposed elements. Our efforts in the virtual survey and during the investigation steps have different aims: to identify the vulnerability of infrastructures, buildings or activities; to execute calculations of exposition to risk; to estimate physical and functional damages. Subsequently, we apply specific algorithms to estimate values of acting forces and physical and functional damages. The updated picture of target areas in terms of risk-prone people, infrastructures and their connections is very important. It is possible to develop algorithms providing values of systemic functionality for each network element. The methodology is here applied to a natech disaster, arising from the combination of a flood event (specifically, the January 2010 flooding of Drin and Buna rivers, with a worsening in the road safety levels in the Shkoder area) with and the subsequent overturning of a truck transporting hazardous material. The accident causes the loss of containment and the total material release. Once the release has taken place, the evolution will depend on the physical state of the substance spilled (liquid, gas or dust). As a specific case we consider the rupture of a trucks transporting liquid fuels such as gasoline through Shkoder downtown. Goods entering in Albania from north pass through Shkoder, indeed a high traffic road that connects Albania with Montenegro and Kosovo crosses Shkoder downtown. We consider a truck overturned in downtown Shkoder during the flooding of January 2010; the gasoline transported by the truck is completely released and a pool fire develops damaging roads. We use the model CHESRM (Chemical Spill Risk Mapper) for identify the threat zones of the accident and as a basis for assessing the potential leads to functional damages to other elements of the considered system. The application of the methodology shows the potential use not only on real time emergency management or prevention but also during post-event management for the evaluation of the functional damage to the affected infrastructure (villages isolated from the rest of the network, villages unable to reach schools, hospitals or other services...) and to set a hierarchy in restoration activities, giving priority to the reconstruction of links between primary nodes.

A fundamental reconsideration of the CRASH3 damage analysis algorithm: the case against uniform ubiquitous linearity between BEV, peak collision force magnitude, and residual damage depth.

PubMed

Singh, Jai

2013-01-01

The objective of this study was a thorough reconsideration, within the framework of Newtonian mechanics and work-energy relationships, of the empirically interpreted relationships employed within the CRASH3 damage analysis algorithm in regards to linearity between barrier equivalent velocity (BEV) or peak collision force magnitude and residual damage depth. The CRASH3 damage analysis algorithm was considered, first in terms of the cases of collisions that produced no residual damage, in order to properly explain the damage onset speed and crush resistance terms. Under the modeling constraints of the collision partners representing a closed system and the a priori assumption of linearity between BEV or peak collision force magnitude and residual damage depth, the equations for the sole realistic model were derived. Evaluation of the work-energy relationships for collisions at or below the elastic limit revealed that the BEV or peak collision force magnitude relationships are bifurcated based upon the residual damage depth. Rather than being additive terms from the linear curve fits employed in the CRASH3 damage analysis algorithm, the Campbell b 0 and CRASH3 AL terms represent the maximum values that can be ascribed to the BEV or peak collision force magnitude, respectively, for collisions that produce zero residual damage. Collisions resulting in the production of non-zero residual damage depth already account for the surpassing of the elastic limit during closure and therefore the secondary addition of the elastic limit terms represents a double accounting of the same. This evaluation shows that the current energy absorbed formulation utilized in the CRASH3 damage analysis algorithm extraneously includes terms associated with the A and G stiffness coefficients. This sole realistic model, however, is limited, secondary to reducing the coefficient of restitution to a constant value for all cases in which the residual damage depth is nonzero. Linearity between BEV or peak collision force magnitude and residual damage depth may be applicable for particular ranges of residual damage depth for any given region of any given vehicle. Within the modeling construct employed by the CRASH3 damage algorithm, the case of uniform and ubiquitous linearity cannot be supported. Considerations regarding the inclusion of internal work recovered and restitution for modeling the separation phase change in velocity magnitude should account for not only the effects present during the evaluation of a vehicle-to-vehicle collision of interest but also to the approach taken for modeling the force-deflection response for each collision partner.

Mental Retardation and the Law: A Report on Status of Current Court Cases. July 1978.

ERIC Educational Resources Information Center

President's Committee on Mental Retardation, Washington, DC.

The issue contains reports on seven new court cases regarding mental retardation and the law and updated information on 35 cases previously reported. Cases concern such issues as classification, commitment, education, employment, sterilization, and treatment. Also included is a feature article on the implications of Halderman v Pennhurst State…

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

President's Committee on Mental Retardation, Washington, DC.

Presented by the President's Committee on Mental Retardation are an analysis of architectural barriers and a summary of new state cases, updated information on previously reported cases, and a listing of cases all concerned with the legal rights of the retarded. Architectural barriers are considered in terms of statutory actions and constitutional…

Boosting cooperation by involving extortion in spatial prisoner's dilemma games

NASA Astrophysics Data System (ADS)

Wu, Zhi-Xi; Rong, Zhihai

2014-12-01

We study the evolution of cooperation in spatial prisoner's dilemma games with and without extortion by adopting the aspiration-driven strategy updating rule. We focus explicitly on how the strategy updating manner (whether synchronous or asynchronous) and also the introduction of extortion strategy affect the collective outcome of the games. By means of Monte Carlo simulations as well as dynamical cluster techniques, we find that the involvement of extortioners facilitates the boom of cooperators in the population (and whom can always dominate the population if the temptation to defect is not too large) for both synchronous and asynchronous strategy updating, in stark contrast to the other case, where cooperation is promoted for an intermediate aspiration level with synchronous strategy updating, but is remarkably inhibited if the strategy updating is implemented asynchronously. We explain the results by configurational analysis and find that the presence of extortion leads to the checkerboard-like ordering of cooperators and extortioners, which enable cooperators to prevail in the population with both strategy updating manners. Moreover, extortion itself is evolutionary stable, and therefore acts as the incubator for the evolution of cooperation.

The Daniel K. Inouye College of Pharmacy Scripts: Updates on Clostridium difficile Infection: Advances in Laboratory Testing to Aid Diagnosis and Treatment.

PubMed

Lteif, Louis

2017-02-01

Clostridium difficile remains a major source of nosocomial infections and associated diarrhea. More recently, community-acquired cases are on the rise creating a concern for a serious public health threat. Appropriate infection control precautions as well as prevention and optimal management may help to avoid detrimental outbreaks. A key step is utilizing laboratory testing for quick and accurate diagnosis of potential cases. This overview article describes Clostridium difficile infection control and prevention methods and updates the most recent management strategies including a focus on the utilization and interpretation of laboratory diagnostic testing and appropriate treatment.

Assessment of potential doses to workers during postulated accident conditions at the Waste Isolation Pilot Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoover, M.D.; Farrell, R.F.; Newton, G.J.

1995-12-01

The recent 1995 WIPP Safety Analysis Report (SAR) Update provided detailed analyses of potential radiation doses to members of the public at the site boundary during postulated accident scenarios at the U.S. Department of Energy`s Waste Isolation Pilot Plant (WIPP). The SAR Update addressed the complete spectrum of potential accidents associated with handling and emplacing transuranic waste at WIPP, including damage to waste drums from fires, punctures, drops, and other disruptions. The report focused on the adequacy of the multiple layers of safety practice ({open_quotes}defense-in-depth{close_quotes}) at WIPP, which are designed to (1) reduce the likelihood of accidents and (2) limitmore » the consequences of those accidents. The safeguards which contribute to defense-in-depth at WIPP include a substantial array of inherent design features, engineered controls, and administrative procedures. The SAR Update confirmed that the defense-in-depth at WIPP is adequate to assure the protection of the public and environment. As a supplement to the 1995 SAR Update, we have conducted additional analyses to confirm that these controls will also provide adequate protection to workers at the WIPP. The approaches and results of the worker dose assessment are summarized here. In conformance with the guidance of DOE Standard 3009-94, we emphasize that use of these evaluation guidelines is not intended to imply that these numbers constitute acceptable limits for worker exposures under accident conditions. However, in conjunction with the extensive safety assessment in the 1995 SAR Update, these results indicate that the Carlsbad Area Office strategy for the assessment of hazards and accidents assures the protection of workers, members of the public, and the environment.« less

Evaluation of a threshold-based model of fatigue in gamma titanium aluminide following impact damage

NASA Astrophysics Data System (ADS)

Harding, Trevor Scott

2000-10-01

Recent interest in gamma titanium aluminide (gamma-TiAl) for use in gas turbine engine applications has centered on the low density and good elevated temperature strength retention of gamma-TiAl compared to current materials. However, the relatively low ductility and fracture toughness of gamma-TiAl leads to serious concerns regarding its ability to resist impact damage. Furthermore, the limited fatigue crack growth resistance of gamma-TiAl means that the potential for fatigue failures resulting from impact damage is real if a damage tolerant design approach is used. A threshold-based design approach may be required if fatigue crack growth from potential impact sites is to be avoided. The objective of the present research is to examine the feasibility of a threshold-based approach for the design of a gamma-TiAl low-pressure turbine blade subjected to both assembly-related impact damage and foreign object damage. Specimens of three different gamma-TiAl alloys were damaged in such a way as to simulate anticipated impact damage for a turbine blade. Step-loading fatigue tests were conducted at both room temperature and 600°C. In terms of the assembly-related impact damage, the results indicate that there is reasonably good agreement between the threshold-based predictions of the fatigue strength of damaged specimens and the measured data. However, some discrepancies do exist. In the case of very lightly damaged specimens, prediction of the resulting fatigue strength requires that a very conservative small-crack fatigue threshold be used. Consequently, the allowable design conditions are significantly reduced. For severely damaged specimens, an analytical approach found that the potential effects of residual stresses may be related to the discrepancies observed between the threshold-based model and measured fatigue strength data. In the case of foreign object damage, a good correlation was observed between impacts resulting in large cracks and a long-crack threshold-based approximation of the fatigue strength. However, in the case of smaller impact sites, a lower small-crack threshold appears to be more appropriate. In some cases, a complete perforation of the material, or blowout, would result from the impact. Prediction of the reduction in fatigue strength resulting from this form of damage required the use of a stress concentration factor, rather than a threshold-based prediction.

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

NASA Kennedy Space Center's Flight Operations prepares to rehearse a helicopter crash-landing to test new and updated emergency procedures. Called the Aircraft Mishap Preparedness and Contingency Plan, the operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Endobronchial Ultrasound (EBUS) - Update 2017.

PubMed

Darwiche, Kaid; Özkan, Filiz; Wolters, Celina; Eisenmann, Stephan

2018-02-01

Endobronchial ultrasound (EBUS) has revolutionized the diagnosis of lung cancer over the last decade. This minimally invasive diagnostic method has also become increasingly important in the case of other diseases such as sarcoidosis, thereby helping to avoid unnecessary diagnostic interventions. This review article provides an update regarding EBUS and discusses current and future developments of this method. © Georg Thieme Verlag KG Stuttgart · New York.

Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis.

PubMed

Shibuya, Masako; Watanabe, Yuichiro; Nunokawa, Ayako; Egawa, Jun; Kaneko, Naoshi; Igeta, Hirofumi; Someya, Toshiyuki

2014-01-01

Interleukin-1 beta (IL-1β) has been implicated in the pathophysiology of schizophrenia. To assess whether the IL1B gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis. We tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers, including common tagging single nucleotide variations (SNVs) and a rare non-synonymous variation detected by resequencing the coding regions. We also performed a meta-analysis of rs16944 using a total of 8724 case-control and 201 trio samples from 16 independent populations. We found no significant associations between any of the 12 SNVs examined and schizophrenia in either case-control or trio samples. Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia. The present study does not support a role for IL1B in schizophrenia susceptibility.

Identification of delaminations in composite: structural health monitoring software based on spectral estimation and hierarchical genetic algorithm

NASA Astrophysics Data System (ADS)

Nag, A.; Mahapatra, D. Roy; Gopalakrishnan, S.

2003-10-01

A hierarchical Genetic Algorithm (GA) is implemented in a high peformance spectral finite element software for identification of delaminations in laminated composite beams. In smart structural health monitoring, the number of delaminations (or any other modes of damage) as well as their locations and sizes are no way completely known. Only known are the healthy structural configuration (mass, stiffness and damping matrices updated from previous phases of monitoring), sensor measurements and some information about the load environment. To handle such enormous complexity, a hierarchical GA is used to represent heterogeneous population consisting of damaged structures with different number of delaminations and their evolution process to identify the correct damage configuration in the structures under monitoring. We consider this similarity with the evolution process in heterogeneous population of species in nature to develop an automated procedure to decide on what possible damaged configuration might have produced the deviation in the measured signals. Computational efficiency of the identification task is demonstrated by considering a single delamination. The behavior of fitness function in GA, which is an important factor for fast convergence, is studied for single and multiple delaminations. Several advantages of the approach in terms of computational cost is discussed. Beside tackling different other types of damage configurations, further scope of research for development of hybrid soft-computing modules are highlighted.

Probabilistic Prognosis of Non-Planar Fatigue Crack Growth

NASA Technical Reports Server (NTRS)

Leser, Patrick E.; Newman, John A.; Warner, James E.; Leser, William P.; Hochhalter, Jacob D.; Yuan, Fuh-Gwo

2016-01-01

Quantifying the uncertainty in model parameters for the purpose of damage prognosis can be accomplished utilizing Bayesian inference and damage diagnosis data from sources such as non-destructive evaluation or structural health monitoring. The number of samples required to solve the Bayesian inverse problem through common sampling techniques (e.g., Markov chain Monte Carlo) renders high-fidelity finite element-based damage growth models unusable due to prohibitive computation times. However, these types of models are often the only option when attempting to model complex damage growth in real-world structures. Here, a recently developed high-fidelity crack growth model is used which, when compared to finite element-based modeling, has demonstrated reductions in computation times of three orders of magnitude through the use of surrogate models and machine learning. The model is flexible in that only the expensive computation of the crack driving forces is replaced by the surrogate models, leaving the remaining parameters accessible for uncertainty quantification. A probabilistic prognosis framework incorporating this model is developed and demonstrated for non-planar crack growth in a modified, edge-notched, aluminum tensile specimen. Predictions of remaining useful life are made over time for five updates of the damage diagnosis data, and prognostic metrics are utilized to evaluate the performance of the prognostic framework. Challenges specific to the probabilistic prognosis of non-planar fatigue crack growth are highlighted and discussed in the context of the experimental results.

Field-scale and wellbore modeling of compaction-induced casing failures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hilbert, L.B. Jr.; Gwinn, R.L.; Moroney, T.A.

1999-06-01

Presented in this paper are the results and verification of field- and wellbore-scale large deformation, elasto-plastic, geomechanical finite element models of reservoir compaction and associated casing damage. The models were developed as part of a multidisciplinary team project to reduce the number of costly well failures in the diatomite reservoir of the South Belridge Field near Bakersfield, California. Reservoir compaction of high porosity diatomite rock induces localized shearing deformations on horizontal weak-rock layers and geologic unconformities. The localized shearing deformations result in casing damage or failure. Two-dimensional, field-scale finite element models were used to develop relationships between field operations, surfacemore » subsidence, and shear-induced casing damage. Pore pressures were computed for eighteen years of simulated production and water injection, using a three-dimensional reservoir simulator. The pore pressures were input to the two-dimensional geomechanical field-scale model. Frictional contact surfaces were used to model localized shear deformations. To capture the complex casing-cement-rock interaction that governs casing damage and failure, three-dimensional models of a wellbore were constructed, including a frictional sliding surface to model localized shear deformation. Calculations were compared to field data for verification of the models.« less

ECIRS (Endoscopic Combined Intrarenal Surgery) in the Galdakao-modified supine Valdivia position: a new life for percutaneous surgery?

PubMed

Cracco, Cecilia Maria; Scoffone, Cesare Marco

2011-12-01

Percutaneous nephrolithotomy (PNL) is still the gold-standard treatment for large and/or complex renal stones. Evolution in the endoscopic instrumentation and innovation in the surgical skills improved its success rate and reduced perioperative morbidity. ECIRS (Endoscopic Combined IntraRenal Surgery) is a new way of affording PNL in a modified supine position, approaching antero-retrogradely to the renal cavities, and exploiting the full array of endourologic equipment. ECIRS summarizes the main issues recently debated about PNL. The recent literature regarding supine PNL and ECIRS has been reviewed, namely about patient positioning, synergy between operators, procedures, instrumentation, accessories and diagnostic tools, step-by-step standardization along with versatility of the surgical sequence, minimization of radiation exposure, broadening to particular and/or complex patients, limitation of post-operative renal damage. Supine PNL and ECIRS are not superior to prone PNL in terms of urological results, but guarantee undeniable anesthesiological and management advantages for both patient and operators. In particular, ECIRS requires from the surgeon a permanent mental attitude to synergy, standardized surgical steps, versatility and adherence to the ongoing clinical requirements. ECIRS can be performed also in particular cases, irrespective to age or body habitus. The use of flexible endoscopes during ECIRS contributes to minimizing radiation exposure, hemorrhagic risk and post-PNL renal damage. ECIRS may be considered an evolution of the PNL procedure. Its proposal has the merit of having triggered the critical analysis of the various PNL steps and of patient positioning, and of having transformed the old static PNL into an updated approach.

Indications of correlation between gravity measurements and isoseismal maps. A case study of Athens basin (Greece)

NASA Astrophysics Data System (ADS)

Dilalos, S.; Alexopoulos, J. D.

2017-05-01

In this paper, we discuss the correlation between isoseismal contour maps and gravity residual anomaly maps and how it might contribute to the characterization of vulnerable areas to earthquake damage, especially in urban areas, where the geophysical data collection is difficult. More specifically, we compare a couple of isoseismal maps that have been produced and published after the catastrophic earthquake of 7th September 1999 (5.9R) in Athens, the metropolis of Greece, with the residual map produced from the processing and data reduction of a gravity survey that has been carried out in the Athens basin recently. The geologic and tectonic regime of the Athens basin is quite complicated and it is still being updated with new elements. Basically it is comprised of four different geotectonic units, one of them considered as the autochthon. During the gravity investigation, 807 gravity stations were collected, based on a grid plan with spacing almost 1 km, covering the entire basin and supported by a newly established gravity base network comprised by thirteen bases. Differential DGPS technique was used for the accurate measurement of all the gravity stations and bases coordinates. After the appropriate data reduction and the construction of the Complete Bouguer Anomaly map, we applied FFT filtering in order to remove the regional component and produce the Residual Anomaly Map. The comparison of the Residual Anomaly Map with the isoseismal contours revealed that the areas with the most damage because of the earthquake were located in the areas with the minimum values of the Residual Anomaly Map.

Investigation of impact phenomena on the marine structures: Part I - On the behaviour of thin-walled double bottom tanker during rock-structure interaction

NASA Astrophysics Data System (ADS)

Prabowo, A. R.; Cho, H. J.; Byeon, J. H.; Bae, D. M.; Sohn, J. M.

2018-01-01

Predicted loads, such as crew, cargo, and structure have been applied as main inputs during ship design and analysis. However, unexpected events on the sea has high possibility to deliver remarkable losses for ship, industry, and environment. Previous oil spill incident by the Exxon Valdez in Alaska is the perfect example which an environmental damage and industry loss are initiated by an impact phenomenon on the ship, i.e. grounding. Even though hull arrangement has adopted double hull system, grounding may threaten ship safety in various scenarios. This situation pushes society to demand sustainable investigation for impact phenomena on water transportation mode to update understanding in the phenomenon and ensure structural safety during ship operation. This work aimed to study structural behaviour of chemical tanker as a marine structure under impact, namely ship grounding. Bottom raking case was considered to be calculated by virtual experiment. The study was performed using nonlinear finite element (FE) method and an idealised geometry of seabed rock would be deployed to be hard obstruction. Observation on the selected crashworthiness criteria, i.e. internal energy and crushing force indicated that as advanced penetration occurred on the ship structure, the absorbed strain energy continued to increase, while major fluctuation appeared during the initial contact between obstruction and ship happened. Damage extent of several structural members during the crushing process was shown, which concluded that the bottom plating had the largest severity in forms of tearing mode among of all members on the bottom structure.

TSARINA: A Computer Model for Assessing Conventional and Chemical Attacks on Airbases

DTIC Science & Technology

1990-09-01

IV, and has been updated to FORTRAN 77; it has been adapted to various computer systems, as was the widely used AIDA model and the previous versions of...conventional and chemical attacks on sortie generation. In the first version of TSARINA [1 2], several key additions were made to the AIDA model so that (1...various on-base resources, in addition to the estimates of hits and facility damage that are generated by the original AIDA model . The second version

Malignant external otitis: The diagnostic value of bone scintigraphy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ostfeld, E.; Aviel, A.; Pelet, D.

1981-06-01

Technetium99m Methylene Diphosphate bone scintigraphy (BS) of the skull was performed in three patients with malignant external otitis (MEO). Pathological uptake of the radioisotope in the mastoid region was found during the early stages of MEO updating radiologic findings. The extent of the radioisotope accumulation during the early stages of MEO indicates that the actual tissue damage exceeds the clinical estimation. The follow-up BS findings correlate well with the clinical course of MEO indicating either healing or extension to the base of skull.

The Revision Decision: Is Change Always Good? A Comparison of CELF-R and CELF-3 Test Scores in Children with Language Impairment, Focal Brain Damage, and Typical Development

ERIC Educational Resources Information Center

Ballantyne, Angela O.; Spilkin, Amy M.; Trauner, Doris A.

2007-01-01

Purpose: The Clinical Evaluation of Language Fundamentals (CELF) is a widely used, comprehensive test battery that assesses language in school-age children and adolescents. The CELF-R (E. Semel, E. H. Wiig, & W. Secord, 1987) was updated to the CELF-3 (E. Semel, E. H. Wiig, & W. A. Secord, 1995) in 1995. The goal of the present study was to…

Method for detecting moment connection fracture using high-frequency transients in recorded accelerations

USGS Publications Warehouse

Rodgers, J.E.; Elebi, M.

2011-01-01

The 1994 Northridge earthquake caused brittle fractures in steel moment frame building connections, despite causing little visible building damage in most cases. Future strong earthquakes are likely to cause similar damage to the many un-retrofitted pre-Northridge buildings in the western US and elsewhere. Without obvious permanent building deformation, costly intrusive inspections are currently the only way to determine if major fracture damage that compromises building safety has occurred. Building instrumentation has the potential to provide engineers and owners with timely information on fracture occurrence. Structural dynamics theory predicts and scale model experiments have demonstrated that sudden, large changes in structure properties caused by moment connection fractures will cause transient dynamic response. A method is proposed for detecting the building-wide level of connection fracture damage, based on observing high-frequency, fracture-induced transient dynamic responses in strong motion accelerograms. High-frequency transients are short (<1 s), sudden-onset waveforms with frequency content above 25 Hz that are visually apparent in recorded accelerations. Strong motion data and damage information from intrusive inspections collected from 24 sparsely instrumented buildings following the 1994 Northridge earthquake are used to evaluate the proposed method. The method's overall success rate for this data set is 67%, but this rate varies significantly with damage level. The method performs reasonably well in detecting significant fracture damage and in identifying cases with no damage, but fails in cases with few fractures. Combining the method with other damage indicators and removing records with excessive noise improves the ability to detect the level of damage. ?? 2010 Elsevier B.V. All rights reserved.

Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients.

PubMed

Shaw, Jyoti; Chakraborty, Ayan; Nag, Arijit; Chattopadyay, Arnab; Dasgupta, Anjan K; Bhattacharyya, Maitreyee

2017-11-01

To investigate the cause and effects of intracellular iron overload in lymphocytes of thalassemia major patients. Sixty-six thalassemia major patients having iron overload and 10 age-matched controls were chosen for the study. Blood sample was collected, and serum ferritin, oxidative stress; lymphocyte DNA damage were examined, and infective episodes were also counted. Case-control analysis revealed significant oxidative stress, iron overload, DNA damage, and rate of infections in thalassemia cases as compared to controls. For cases, oxidative stress (ROS) and iron overload (serum ferritin) showed good correlation with R 2  = 0.934 and correlation between DNA damage and ROS gave R 2  = 0.961. We also demonstrated that intracellular iron overload in thalassemia caused oxidative damage of lymphocyte DNA as exhibited by DNA damage assay. The inference is further confirmed by partial inhibition of such damage by chelation of iron and the concurrent lowering of the ROS level in the presence of chelator deferasirox. Therefore, intracellular iron overload caused DNA fragmentation, which may ultimately hamper lymphocyte function, and this may contribute to immune dysfunction and increased susceptibility to infections in thalassemia patients as indicated by the good correlation (R 2  = 0.91) between lymphocyte DNA damage and rate of infection found in this study. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Sickle cell disease

PubMed Central

2016-01-01

Introduction Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to one third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 369 studies. After deduplication and removal of conference abstracts, 136 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 99 studies and the further review of 37 full publications. Of the 37 full articles evaluated, three already included systematic reviews were updated, two systematic reviews, two RCTs, and one subsequent RCT were added at this update. We performed a GRADE evaluation for 12 PICO combinations. Conclusions In this systematic overview, we categorised the efficacy for five interventions based on information about the effectiveness and safety of antibiotic prophylaxis in children aged under 5 years, antibiotic prophylaxis in children aged 5 years or older, hydroxyurea, malaria chemoprophylaxis, and pneumococcal vaccines. PMID:26808098

The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses

PubMed Central

Aurora, R. Nisha; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Zak, Rochelle S.; Casey, Kenneth R.; Lamm, Carin I.; Tracy, Sharon L.; Rosenberg, Richard S.

2012-01-01

A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a STANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS. Citation: Aurora RN; Kristo DA; Bista SR; Rowley JA: Zak RS; Casey KR; Lamm CI; Tracy SL; Rosenberg RS. The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. SLEEP 2012;35(8):1039-1062. PMID:22851801

Closed-form integrator for the quaternion (euler angle) kinematics equations

NASA Technical Reports Server (NTRS)

Whitmore, Stephen A. (Inventor)

2000-01-01

The invention is embodied in a method of integrating kinematics equations for updating a set of vehicle attitude angles of a vehicle using 3-dimensional angular velocities of the vehicle, which includes computing an integrating factor matrix from quantities corresponding to the 3-dimensional angular velocities, computing a total integrated angular rate from the quantities corresponding to a 3-dimensional angular velocities, computing a state transition matrix as a sum of (a) a first complementary function of the total integrated angular rate and (b) the integrating factor matrix multiplied by a second complementary function of the total integrated angular rate, and updating the set of vehicle attitude angles using the state transition matrix. Preferably, the method further includes computing a quanternion vector from the quantities corresponding to the 3-dimensional angular velocities, in which case the updating of the set of vehicle attitude angles using the state transition matrix is carried out by (a) updating the quanternion vector by multiplying the quanternion vector by the state transition matrix to produce an updated quanternion vector and (b) computing an updated set of vehicle attitude angles from the updated quanternion vector. The first and second trigonometric functions are complementary, such as a sine and a cosine. The quantities corresponding to the 3-dimensional angular velocities include respective averages of the 3-dimensional angular velocities over plural time frames. The updating of the quanternion vector preserves the norm of the vector, whereby the updated set of vehicle attitude angles are virtually error-free.

Classification of the severe trauma patient with the Abbreviated Injury Scale: degree of correlation between versions 98 and 2005 (2008 update).

PubMed

Abajas Bustillo, Rebeca; Leal Costa, César; Ortego Mate, María Del Carmen; Zonfrillo, Mark R; Seguí Gómez, María; Durá Ros, María Jesús

2018-02-01

To explore differences in severity classifications according to 2 versions of the Abbreviated Injury Scale (AIS): version 2005 (the 2008 update) and the earlier version 98. To determine whether possible differences might have an impact on identifying severe trauma patients. Descriptive study and cross-sectional analysis of a case series of patients admitted to two spanish hospitals with out-of-hospital injuries between February 2012 and February 2013. For each patient we calculated the Injury Severity Score (ISS), the New Injury Severity Score (NISS), and the AIS scores according to versions 98 and 2005. The sample included 699 cases. The mean Severity (SD) age of patients was 52.7 (29.2) years, and 388 (55.5%) were males. Version 98 of the AIS correlated more strongly with both the ISS (2.6%) and the NISS (2.9%). The 2008 update of the AIS (version 2005) classified fewer trauma patients than version 98 at the severity levels indicated by the ISS and NISS.

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

PubMed Central

Bernhagen, Jürgen; Bucala, Richard

2013-01-01

Sepsis and septic shock are among the leading causes of death in intensive care units worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines are important pleiotropic regulators of the immune response, which have a crucial role in the complex pathophysiology underlying sepsis. They have both pro- and anti-inflammatory functions and are capable of coordinating effective defense mechanisms against invading pathogens. On the other hand, cytokines may dysregulate the immune response and promote tissue-damaging inflammation. In this review, we address the current knowledge of the actions of pro- and anti-inflammatory cytokines in sepsis pathophysiology as well as how these cytokines and other important immunomodulating agents may be therapeutically targeted to improve the clinical outcome of sepsis. PMID:23853427

Study flow diagrams in Cochrane systematic review updates: an adapted PRISMA flow diagram

PubMed Central

2014-01-01

Cochrane systematic reviews are conducted and reported according to rigorous standards. A study flow diagram must be included in a new review, and there is clear guidance from the PRISMA statement on how to do this. However, for a review update, there is currently no guidance on how study flow diagrams should be presented. To address this, a working group was formed to find a solution and produce guidance on how to use these diagrams in review updates. A number of different options were devised for how these flow diagrams could be used in review updates, and also in cases where multiple searches for a review or review update have been conducted. These options were circulated to the Cochrane information specialist community for consultation and feedback. Following the consultation period, the working group refined the guidance and made the recommendation that for review updates an adapted PRISMA flow diagram should be used, which includes an additional box with the number of previously included studies feeding into the total. Where multiple searches have been conducted, the results should be added together and treated as one set of results. There is no existing guidance for using study flow diagrams in review updates. Our adapted diagram is a simple and pragmatic solution for showing the flow of studies in review updates. PMID:24886533

An Adaptive Pheromone Updation of the Ant-System using LMS Technique

NASA Astrophysics Data System (ADS)

Paul, Abhishek; Mukhopadhyay, Sumitra

2010-10-01

We propose a modified model of pheromone updation for Ant-System, entitled as Adaptive Ant System (AAS), using the properties of basic Adaptive Filters. Here, we have exploited the properties of Least Mean Square (LMS) algorithm for the pheromone updation to find out the best minimum tour for the Travelling Salesman Problem (TSP). TSP library has been used for the selection of benchmark problem and the proposed AAS determines the minimum tour length for the problems containing large number of cities. Our algorithm shows effective results and gives least tour length in most of the cases as compared to other existing approaches.

Trends in hospital labor and total factor productivity, 1981-86

PubMed Central

Cromwell, Jerry; Pope, Gregory C.

1989-01-01

The per-case payment rates of Medicare's prospective payment system are annually updated. As one element of the update factor, Congress required consideration of changes in hospital productivity. In this article, calculations of annual changes in labor and total factor productivity during 1981-86 of hospitals eligible for prospective payment are presented using several output and input variants. Generally, productivity has declined since 1980, although the rates of decline have slowed since prospective payment implementation. According to the series of analyses most relevant for policy, significant hospital productivity gains occurred during 1983-86. This may justify a lower update factor. PMID:10313278

Mental Retardation and the Law: A Report on Status of Current Court Cases.

ERIC Educational Resources Information Center

Friedman, Paul R.; Beck, Ronna Lee

Featured in the issue is an analysis of the Supreme Court's decision on O'Connor v. Donaldson, and provided are updated summaries of 104 cases previously reported in the publication. Reviewed are cases on the following topic areas: architectural barriers, classification, commitment, custody, education, employment, guardianship, protection from…

Patterns of Practice: Case Studies of Early Childhood Education & Family Engagement in Community Schools

ERIC Educational Resources Information Center

Jacobson, Linda; Rollins, S. Kwesi; Brown, Janet; Naviasky, Heather

2016-01-01

This "Patterns of Practice: Case Studies of Early Childhood Education & Family Engagement in Community Schools" report updates the community school case studies through a description of ongoing developments in Cincinnati, OH; Evansville, IN; Multnomah County, OR; and Tulsa, OK and adds to that knowledge base of early learning and…

76 FR 61725 - Agency Information Collection Activities: Case Submission Form, Case Assistance Form; (Form DHS...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

..., Case Assistance Form; (Form DHS-7001), Online Ombudsman Form DHS-7001 AGENCY: Office of the Citizenship... System'' to ``Online Ombudsman Form DHS-7001''. The instructions have been updated to reflect the... Services Ombudsman--001 Virtual Ombudsman System (March 2010) to reflect the name change to Online...

42 CFR 412.308 - Determining and updating the Federal rate.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., changes in the case mix index, the effect of changes to DRG classification and relative weights, and... increase attributable to changes in case mix. (ii) Effective FY 1996. Effective FY 1996, the standard... under the Federal rate for outlier cases under subpart F of this part, determined as a proportion of...

Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update

PubMed Central

Graham, Stephen M.; Cuevas, Luis E.; Jean-Philippe, Patrick; Browning, Renee; Casenghi, Martina; Detjen, Anne K.; Gnanashanmugam, Devasena; Hesseling, Anneke C.; Kampmann, Beate; Mandalakas, Anna; Marais, Ben J.; Schito, Marco; Spiegel, Hans M. L.; Starke, Jeffrey R.; Worrell, Carol; Zar, Heather J.

2015-01-01

Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results. PMID:26409281

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

Members of NASA Kennedy Space Center's Flight Operations team participate in a rehearsal of a helicopter crash-landing to test new and updated emergency procedures. Called the Aircraft Mishap Preparedness and Contingency Plan, the operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

NASA Kennedy Space Center's Flight Operations team reviews procedures before beginning a rehearsal of a helicopter crash-landing to test new and updated emergency procedures. Called the Aircraft Mishap Preparedness and Contingency Plan, the operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

Members of NASA Kennedy Space Center's Flight Operations team prepare for a rehearsal of a helicopter crash-landing to test new and updated emergency procedures. Called the Aircraft Mishap Preparedness and Contingency Plan, the operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

A member of NASA Kennedy Space Center's Flight Operations team prepares for a rehearsal of a helicopter crash-landing to test new and updated emergency procedures. Called the Aircraft Mishap Preparedness and Contingency Plan, the operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Development of reversible jump Markov Chain Monte Carlo algorithm in the Bayesian mixture modeling for microarray data in Indonesia

NASA Astrophysics Data System (ADS)

Astuti, Ani Budi; Iriawan, Nur; Irhamah, Kuswanto, Heri

2017-12-01

In the Bayesian mixture modeling requires stages the identification number of the most appropriate mixture components thus obtained mixture models fit the data through data driven concept. Reversible Jump Markov Chain Monte Carlo (RJMCMC) is a combination of the reversible jump (RJ) concept and the Markov Chain Monte Carlo (MCMC) concept used by some researchers to solve the problem of identifying the number of mixture components which are not known with certainty number. In its application, RJMCMC using the concept of the birth/death and the split-merge with six types of movement, that are w updating, θ updating, z updating, hyperparameter β updating, split-merge for components and birth/death from blank components. The development of the RJMCMC algorithm needs to be done according to the observed case. The purpose of this study is to know the performance of RJMCMC algorithm development in identifying the number of mixture components which are not known with certainty number in the Bayesian mixture modeling for microarray data in Indonesia. The results of this study represent that the concept RJMCMC algorithm development able to properly identify the number of mixture components in the Bayesian normal mixture model wherein the component mixture in the case of microarray data in Indonesia is not known for certain number.

Adaptive model-based control systems and methods for controlling a gas turbine

NASA Technical Reports Server (NTRS)

Brunell, Brent Jerome (Inventor); Mathews, Jr., Harry Kirk (Inventor); Kumar, Aditya (Inventor)

2004-01-01

Adaptive model-based control systems and methods are described so that performance and/or operability of a gas turbine in an aircraft engine, power plant, marine propulsion, or industrial application can be optimized under normal, deteriorated, faulted, failed and/or damaged operation. First, a model of each relevant system or component is created, and the model is adapted to the engine. Then, if/when deterioration, a fault, a failure or some kind of damage to an engine component or system is detected, that information is input to the model-based control as changes to the model, constraints, objective function, or other control parameters. With all the information about the engine condition, and state and directives on the control goals in terms of an objective function and constraints, the control then solves an optimization so the optimal control action can be determined and taken. This model and control may be updated in real-time to account for engine-to-engine variation, deterioration, damage, faults and/or failures using optimal corrective control action command(s).

Extended Kalman filtering for the detection of damage in linear mechanical structures

NASA Astrophysics Data System (ADS)

Liu, X.; Escamilla-Ambrosio, P. J.; Lieven, N. A. J.

2009-09-01

This paper addresses the problem of assessing the location and extent of damage in a vibrating structure by means of vibration measurements. Frequency domain identification methods (e.g. finite element model updating) have been widely used in this area while time domain methods such as the extended Kalman filter (EKF) method, are more sparsely represented. The difficulty of applying EKF in mechanical system damage identification and localisation lies in: the high computational cost, the dependence of estimation results on the initial estimation error covariance matrix P(0), the initial value of parameters to be estimated, and on the statistics of measurement noise R and process noise Q. To resolve these problems in the EKF, a multiple model adaptive estimator consisting of a bank of EKF in modal domain was designed, each filter in the bank is based on different P(0). The algorithm was iterated by using the weighted global iteration method. A fuzzy logic model was incorporated in each filter to estimate the variance of the measurement noise R. The application of the method is illustrated by simulated and real examples.

Update: Science and security

NASA Astrophysics Data System (ADS)

Richman, Barbara T.

Although ‘a substantial and serious technology transfer [to the Soviet Union] exists,’ open communication of federally funded research does not damage our national security, according to Dale R. Corson, president emeritus of Cornell University and chairman of the National Academy of Sciences' Panel on Scientific Communication and National Security. Corson characterized those technology transfers at a recent press conference on the panel's findings, which are summarized in their report, ‘Science Communications and National Security’ (Eos, October 5, p. 801).‘A net flow of products, processes, and ideas is continually moving from the United States and its allies to the Soviet Union, through both overt and covert means,’ Corson said. While some of this technology transfer has not compromised national security (‘in part because a technology in question had little or no military significance’), a ‘substantial portion of the transfer has been damaging to national security,’ Corson explained. The ‘damaging transfers’ occur through the ‘legal as well as illegal sale of products, through transfers via third countries, and through a highly organized espionage operation.’

[Application of damage control concept in severe limbs fractures combining with multiple trauma].

PubMed

Bayin, Er-gu-le; Jin, Hong-bing; Li, Ming

2015-09-01

To discuss the application and clinical effect of damage control concept in the treatment of severe limbs fractures combining with multiple trauma. From July 2009 to July 2012, 30 patients with severe limbs fractures combining with multiple trauma were treated with the damage control concept, included 20 males and 10 females with an average age of (34.03 ± 12.81) years old ranging from 20 to 60 years old; the ISS averaged (35.00 ± 12.81) points (ranged from 26 to 54 points). And the control group also contained 30 patients with severe limbs fractures combining with multiple trauma treated by the traditional operation from June 2006 to June 2009, there were 23 males and 7 females with an average age of (34.23 ± 11.04) years old ranging from 18 to 65 years old. The ISS averaged (35.56 ± 11.04) points (ranged from 26 to 51 points). The age, gender, ISS, Gustilo classification, operation time, intraoperative blood loss, blood transfusion,postoperative complications and mortality rate were observed and compared. In the damage control concept group,there were 28 cases surviving and 2 cases (6.7%) death; 6 cases of postoperative complication included 2 cases of adult respiratory distress syndrome, 1 case of multiple organ failure, 1 case of disseminated intravascular coagulation and 2 cases of wound infection. In the control group, there were 22 cases surviving and 8 cases death(26.7%); 13 cases of postoperative complication included 4 cases of adult respiratory distress syndrome,2 cases of multiple organ failure, 2 cases of disseminated intravascular coagulation and 3 cases of wound infection. There were no statistically significant differences between two groups in age, gender, ISS, Gustilo classfication and complication (P > 0.05), however there were statistically significant differences in mortality rate, operation time, blodd loss, blodd transfusion between two groups (P < 0.05). Damage control concept is used to treat severe limbs fractures combining with multiple trauma which has the rapid and effective therapy, can improve survival rate and reduce complication.

Pediatric Vesicoureteral Reflux Guidelines Panel Summary Report: Clinical Practice Guidelines for Screening Siblings of Children With Vesicoureteral Reflux and Neonates/Infants With Prenatal Hydronephrosis.

PubMed

Skoog, Steven J; Peters, Craig A; Arant, Billy S; Copp, Hillary L; Elder, Jack S; Hudson, R Guy; Khoury, Antoine E; Lorenzo, Armando J; Pohl, Hans G; Shapiro, Ellen; Snodgrass, Warren T; Diaz, Mireya

2010-09-01

The American Urological Association established the Vesicoureteral Reflux Guideline Update Committee in July 2005 to update the management of primary vesicoureteral reflux in children guideline. The Panel defined the task into 5 topics pertaining to specific vesicoureteral reflux management issues, which correspond to the management of 3 distinct index patients and the screening of 2 distinct index patients. This report summarizes the existing evidence pertaining to screening of siblings and offspring of index patients with vesicoureteral reflux and infants with prenatal hydronephrosis. From this evidence clinical practice guidelines are developed to manage the clinical scenarios insofar as the data permit. The Panel searched the MEDLINE(R) database from 1994 to 2008 for all relevant articles dealing with the 5 chosen guideline topics. The database was reviewed and each abstract segregated into a specific topic area. Exclusions were case reports, basic science, secondary reflux, review articles and not relevant. The extracted article to be accepted should have assessed a cohort of children, clearly stating the number of children undergoing screening for vesicoureteral reflux. Vesicoureteral reflux should have been diagnosed with a cystogram and renal outcomes assessed by nuclear scintigraphy. The screening articles were extracted into data tables developed to evaluate epidemiological factors, patient and renal outcomes, and results of treatment. The reporting of meta-analysis of observational studies elaborated by the MOOSE group was followed. The extracted data were analyzed and formulated into evidence-based recommendations regarding the screening of siblings and offspring in index cases with vesicoureteral reflux and infants with prenatal hydronephrosis. In screened populations the prevalence of vesicoureteral reflux is 27.4% in siblings and 35.7% in offspring. Prevalence decreases at a rate of 1 screened person every 3 months of age. The prevalence is the same in males and females. Bilateral reflux prevalence is similar to unilateral reflux. Grade I-II reflux is estimated to be present in 16.7% and grade III-V reflux in 9.8% of screened patients. The estimate for renal cortical abnormalities overall is 19.3%, with 27.8% having renal damage in cohorts of symptomatic and asymptomatic children combined. In asymptomatic siblings only the rate of renal damage is 14.4%. There are presently no randomized, controlled trials of treated vs untreated screened siblings with vesicoureteral reflux to evaluate health outcomes as spontaneous resolution, decreased rates of urinary infection, pyelonephritis or renal scarring. In screened populations with prenatal hydronephrosis the prevalence of vesicoureteral reflux is 16.2%. Reflux in the contralateral nondilated kidney accounted for a mean of 25.2% of detected cases for a mean prevalence of 4.1%. In patients with a normal postnatal renal ultrasound the prevalence of reflux is 17%. The prenatal anteroposterior renal pelvic diameter was not predictive of reflux prevalence. A diameter of 4 mm is associated with a 10% to 20% prevalence of vesicoureteral reflux. The prevalence of reflux is statistically significantly greater in females (23%) than males (16%) (p=0.022). Reflux grade distribution is approximately a third each for grades I-II, III and IV-V. The estimate of renal damage in screened infants without infection is 21.8%. When stratified by reflux grade renal damage was estimated to be present in 6.2% grade I-III and 47.9% grade IV-V (p <0.0001). The risk of urinary tract infection in patients with and without prenatal hydronephrosis and vesicoureteral reflux could not be determined. The incidence of reported urinary tract infection in patients with reflux was 4.2%. The meta-analysis provided meaningful information regarding screening for vesicoureteral reflux. However, the lack of randomized clinical trials for screened patients to assess clinical health outcomes has made evidence-based guideline recommendations difficult. Consequently, screening guidelines are based on present practice, risk assessment, meta-analysis results and Panel consensus. 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

The Gist of Juries: Testing a Model of Damage Award Decision Making

PubMed Central

Reyna, Valerie F.; Hans, Valerie P.; Corbin, Jonathan C.; Yeh, Ryan; Lin, Kelvin; Royer, Caisa

2017-01-01

Despite the importance of damage awards, juries are often at sea about the amounts that should be awarded, with widely differing awards for cases that seem comparable. We tested a new model of damage award decision making by systematically varying the size, context, and meaningfulness of numerical comparisons or anchors. As a result, we were able to elicit large differences in award amounts that replicated for 2 different cases. Although even arbitrary dollar amounts (unrelated to the cases) influenced the size of award judgments, the most consistent effects of numerical anchors were achieved when the amounts were meaningful in the sense that they conveyed the gist of numbers as small or large. Consistent with the model, the ordinal gist of the severity of plaintiff’s damages and defendant’s liability predicted damage awards, controlling for other factors such as motivation for the award-judgment task and perceived economic damages. Contrary to traditional dual-process approaches, numeracy and cognitive style (e.g., need for cognition and cognitive reflection) were not significant predictors of these numerical judgments, but they were associated with lower levels of variability once the gist of the judgments was taken into account. Implications for theory and policy are discussed. PMID:29075092

The Clinical Test of Nano gold Cosmetic for Recovering Skin Damage Due to Chemicals: Special Case

NASA Astrophysics Data System (ADS)

Taufikurohmah, T.; Wardana, A. P.; Tjahjani, S.; Sanjaya, I. G. M.; Baktir, A.; Syahrani, A.

2018-01-01

Manufacturing of Nano gold cosmetics was done at PT. Gizi Indonesia. Clinical trials to cosmetics data supported that cosmetics are able to treat skin health which has been reported partially. For special cases, the recovery process of facial skin damage should also receive attention including cases of facial skin damage caused by chemicals such as phenol, HCl, aqua regia or other harsh chemicals. The problem determined whether the Nano gold is able to recover skin damage due to the harsh chemicals. This clinical trial data on the forms of early skin damage caused by phenol was delivered in the forms of facial photos patients. The recovery progress of facial skin condition was obtained every week for two months. The data included the forms of widespread wounds during the recovery process. This statement supported by anova statistical analysis of the widespread wound changing every week for 8 times. The conclusion is skin damage due to Phenol impregnation can be recovered with the use of Nano gold cosmetics for 8 weeks. This results support the manufacturing of Nano gold cosmetics for the needs of society. It also suggest that Nano gold material can be used for medicine manufacturing in the future.

A Continuum Damage Mechanics Model for the Static and Cyclic Fatigue of Cellular Composites

PubMed Central

Huber, Otto

2017-01-01

The fatigue behavior of a cellular composite with an epoxy matrix and glass foam granules is analyzed and modeled by means of continuum damage mechanics. The investigated cellular composite is a particular type of composite foam, and is very similar to syntactic foams. In contrast to conventional syntactic foams constituted by hollow spherical particles (balloons), cellular glass, mineral, or metal place holders are combined with the matrix material (metal or polymer) in the case of cellular composites. A microstructural investigation of the damage behavior is performed using scanning electron microscopy. For the modeling of the fatigue behavior, the damage is separated into pure static and pure cyclic damage and described in terms of the stiffness loss of the material using damage models for cyclic and creep damage. Both models incorporate nonlinear accumulation and interaction of damage. A cycle jumping procedure is developed, which allows for a fast and accurate calculation of the damage evolution for constant load frequencies. The damage model is applied to examine the mean stress effect for cyclic fatigue and to investigate the frequency effect and the influence of the signal form in the case of static and cyclic damage interaction. The calculated lifetimes are in very good agreement with experimental results. PMID:28809806

Investigating the Effect of Damage Progression Model Choice on Prognostics Performance

NASA Technical Reports Server (NTRS)

Daigle, Matthew; Roychoudhury, Indranil; Narasimhan, Sriram; Saha, Sankalita; Saha, Bhaskar; Goebel, Kai

2011-01-01

The success of model-based approaches to systems health management depends largely on the quality of the underlying models. In model-based prognostics, it is especially the quality of the damage progression models, i.e., the models describing how damage evolves as the system operates, that determines the accuracy and precision of remaining useful life predictions. Several common forms of these models are generally assumed in the literature, but are often not supported by physical evidence or physics-based analysis. In this paper, using a centrifugal pump as a case study, we develop different damage progression models. In simulation, we investigate how model changes influence prognostics performance. Results demonstrate that, in some cases, simple damage progression models are sufficient. But, in general, the results show a clear need for damage progression models that are accurate over long time horizons under varied loading conditions.

An enhancement to the NA4 gear vibration diagnostic parameter

NASA Technical Reports Server (NTRS)

Decker, Harry J.; Handschuh, Robert F.; Zakrajsek, James J.

1994-01-01

A new vibration diagnostic parameter for health monitoring of gears, NA4*, is proposed and tested. A recently developed gear vibration diagnostic parameter NA4 outperformed other fault detection methods at indicating the start and initial progression of damage. However, in some cases, as the damage progressed, the sensitivity of the NA4 and FM4 parameters tended to decrease and no longer indicated damage. A new parameter, NA4* was developed by enhancing NA4 to improve the trending of the parameter. This allows for the indication of damage both at initiation and also as the damage progresses. The NA4* parameter was verified and compared to the NA4 and FM4 parameters using experimental data from single mesh spur and spiral bevel gear fatigue rigs. The primary failure mode for the test cases was naturally occurring tooth surface pitting. The NA4* parameter is shown to be a more robust indicator of damage.

Earthquake and Tsunami Disaster Mitigation in the Marmara Region and Disaster Education in Turkey Part3

NASA Astrophysics Data System (ADS)

Kaneda, Yoshiyuki; Ozener, Haluk; Meral Ozel, Nurcan; Kalafat, Dogan; Ozgur Citak, Seckin; Takahashi, Narumi; Hori, Takane; Hori, Muneo; Sakamoto, Mayumi; Pinar, Ali; Oguz Ozel, Asim; Cevdet Yalciner, Ahmet; Tanircan, Gulum; Demirtas, Ahmet

2017-04-01

There have been many destructive earthquakes and tsunamis in the world.The recent events are, 2011 East Japan Earthquake/Tsunami in Japan, 2015 Nepal Earthquake and 2016 Kumamoto Earthquake in Japan, and so on. And very recently a destructive earthquake occurred in Central Italy. In Turkey, the 1999 Izmit Earthquake as the destructive earthquake occurred along the North Anatolian Fault (NAF). The NAF crosses the Sea of Marmara and the only "seismic gap" remains beneath the Sea of Marmara. Istanbul with high population similar to Tokyo in Japan, is located around the Sea of Marmara where fatal damages expected to be generated as compound damages including Tsunami and liquefaction, when the next destructive Marmara Earthquake occurs. The seismic risk of Istanbul seems to be under the similar risk condition as Tokyo in case of Nankai Trough earthquake and metropolitan earthquake. It was considered that Japanese and Turkish researchers can share their own experiences during past damaging earthquakes and can prepare for the future large earthquakes in cooperation with each other. Therefore, in 2013 the two countries, Japan and Turkey made an agreement to start a multidisciplinary research project, MarDiM SATREPS. The Project runs researches to aim to raise the preparedness for possible large-scale earthquake and Tsunami disasters in Marmara Region and it has four research groups with the following goals. 1) The first one is Marmara Earthquake Source region observational research group. This group has 4 sub-groups such as Seismicity, Geodesy, Electromagnetics and Trench analyses. Preliminary results such as seismicity and crustal deformation on the sea floor in Sea of Marmara have already achieved. 2) The second group focuses on scenario researches of earthquake occurrence along the North Anatolia Fault and precise tsunami simulation in the Marmara region. Research results from this group are to be the model of earthquake occurrence scenario in Sea of Marmara and the case studies with advanced tsunami simulation for measure cities. 3) Aims of the third group are improvements and constructions of seismic characterizations and damage predictions based on observation researches and precise simulations. Research results from this group will be very important for disaster measures. 4) The fourth group is promoting disaster educations using research result visuals. The mission of this group is very important for information dissemination and practical and effective disaster education in Turkey. The research results from all components will be integrated and utilized for disaster mitigation in Marmara region and disaster education in Turkey. Updated research results of the MarDiM SATREPS Project will be officially presented toward the end of the Project period, which is March 2018.

Avast Ye Salty Dogs: Salt damage in the context of coastal residential construction and historical maritime timbers

Treesearch

Grant T. Kirker; Samuel L. Zelinka; Leandro Passarini

2016-01-01

Salt damage is a frequent problem in wood exposed to seawater and other saline environments. Symptoms of salt damage are often referred to as fuzzy wood and have been historically considered non-structural damage, but a growing number of customer inquiries have prompted a re-evaluation of this phenomenon. This paper details several case studies involving salt damage,...

Using insurance data to learn more about damages to buildings caused by surface runoff

NASA Astrophysics Data System (ADS)

Bernet, Daniel; Roethlisberger, Veronika; Prasuhn, Volker; Weingartner, Rolf

2015-04-01

In Switzerland, almost forty percent of total insurance loss due to natural hazards in the last two decades was caused by flooding. Those flood damages occurred not only within known inundation zones of water courses. Practitioners expect that roughly half of all flood damages lie outside of known inundation zones. In urban areas such damages may simply be caused by drainage system overload for instance. However, as several case studies show, natural and agricultural land play a major role in surface runoff formation leading to damages in rural and peri-urban areas. Although many damages are caused by surface runoff, the whole process chain including surface runoff formation, propagation through the landscape and damages to buildings is not well understood. Therefore, within the framework of a project, we focus our research on this relevant process. As such flash flood events have a very short response time and occur rather diffusely in the landscape, this process is very difficult to observe directly. Therefore indirect data sources with the potential to indicate spatial and temporal distributions of the process have to be used. For that matter, post-flood damage data may be a profitable source. Namely, insurance companies' damage claim records could provide a good picture about the spatial and temporal distributions of damages caused by surface runoff and, thus, about the process itself. In our research we analyze insurance data records of flood damage claims systematically to infer main drivers and influencing factors of surface runoff causing damages to buildings. To demonstrate the potential and drawbacks of using data from insurance companies in relation to damages caused by surface runoff, a case study is presented. A well-documented event with data from a public as well as a private insurance company is selected. The case study focuses on the differences of the datasets as well as the associated problems and advantages respectively. Furthermore, the analysis of the data, especially the crucial identification of damages caused by surface runoff opposed to damages caused by other processes such as riverine flooding, drainage system surcharges etc. are discussed.

Rapid mapping of hurricane damage to forests

Treesearch

Erik M. Nielsen

2009-01-01

The prospects for producing rapid, accurate delineations of the spatial extent of forest wind damage were evaluated using Hurricane Katrina as a test case. A damage map covering the full spatial extent of Katrina?s impact was produced from Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery using higher resolution training data. Forest damage...

The application of continuum damage mechanics to solve problems in geodynamics

NASA Astrophysics Data System (ADS)

Manaker, David Martin

Deformation within the Earth's lithosphere is largely controlled by the rheology of the rock. Ductile behavior in rocks is often associated with plasticity due to dislocation motion or diffusion under high pressures and temperatures. However, ductile behavior can also occur in brittle materials. An example would be cataclastic flow associated with folding at shallow crustal levels, steep subduction zones, and large-scale deformation at plate boundaries. Engineers utilize damage mechanics to model the continuum deformation of brittle materials. We utilize a modified form of damage mechanics where damage represents a reduction in frictional strength and includes a yield stress. We use this empirical approach to simulate the bending of the lithosphere. We use numerical simulations to obtain elastostatic solutions for plate bending and where the stress exceeds a yield stress, we apply damage to reduce the elastic moduli. Damage is calculated at each time step by a power-law relationship of the ratio of the yield stress to stress and the yield strain to the strain. To test our method, we apply our damage rheology to a plate deforming under applied shear, a constant bending moment, and a constant load. We simulate a wide range of behaviors from slow relaxation to instantaneous failure, over timescales that span six orders of magnitude. Stress relaxation produces elastic-perfectly plastic behavior in cases where failure does not occur. For cases of failure, we observe a rapid increase in damage leading to failure. The changes in the rate of damage accumulation in failure cases are similar to the changes in b-values of acoustic emissions observed in triaxial compression tests of fractured rock and b-value changes prior to some large earthquakes. Thus continuum damage mechanics can simulate ductile behavior due to brittle mechanisms as well as observations of laboratory experiments and seismicity.

Satellite Imagery Analysis for Nighttime Temperature Inversion Clouds

NASA Technical Reports Server (NTRS)

Kawamoto, K.; Minnis, P.; Arduini, R.; Smith, W., Jr.

2001-01-01

Clouds play important roles in the climate system. Their optical and microphysical properties, which largely determine their radiative property, need to be investigated. Among several measurement means, satellite remote sensing seems to be the most promising. Since most of the cloud algorithms proposed so far are daytime use which utilizes solar radiation, Minnis et al. (1998) developed a nighttime use one using 3.7-, 11 - and 12-microns channels. Their algorithm, however, has a drawback that is not able to treat temperature inversion cases. We update their algorithm, incorporating new parameterization by Arduini et al. (1999) which is valid for temperature inversion cases. This updated algorithm has been applied to GOES satellite data and reasonable retrieval results were obtained.

A fracture mechanics analysis of impact damage in a thick composite laminate

NASA Technical Reports Server (NTRS)

Poe, C. C., Jr.

1985-01-01

Graphite/epoxy filament-wound cases (FWC) for the solid rocket motors of the space shuttle are being made by NASA. The FWC cases are wound with AS4W graphite fiber impregnated with an epoxy resin and are about 1.4 inches or more thick. Graphite-epoxy composite laminates, unlike metals, can be damaged easily by low velocity impacts of objects like dropped tools. The residual tension strength of the FWC laminate, after impact, is being studied at Langley Research Center. The conditions that give minimum visual evidence of damage are being emphasized. A fracture mechanics analysis was developed to predict the residual strength, after impact, using radiographs to measure the size of the damage and an equivalent surface crack to represent the damage.

The Ultimate Strength of Double Hull Oil Tanker Due to Grounding and Collision

NASA Astrophysics Data System (ADS)

Izaak Latumahina, Samuel; Zubair Muis Alie, Muhammad; Sitepu, Ganding

2018-02-01

The damaged tanker by grounding and collision may totally collapse if loss its buoyancy, stability and suffer structural failure. The objective of the present study is to investigate the ultimate strength of double hull oil tanker under vertical bending moments due to grounding and collision. The damages are modelled by removing the elements consist of stiffened and unstiffened plates from the damages part. One-frame space of the double hull oil tanker is taken to be analysed. Two damages cases are considered in the analyses those are grounding and collision. The transversal damage extent for grounding are 10%, 25%, 40% and 55%. The groundings are placed at symmetric position on the outer bottom part. For the case of collision, the vertical damage extent are taken as 10%, 20%, 40% and 60%. The transversal damages extent is taken to be B/16 and it is constant for all collision damages. The investigation of the ultimate strength is performed by the Non-Linear Finite Element Analysis method under moment control. The boundary condition is applied with fully constrained on all nodes at the aft-end, while the rigid linked on all nodes is attached at the fore-end with respect to the reference point on the neutral axis. The initial imperfection, welding residual stress and crack are not considered in the analyses. The results obtained by Non-Linear Finite Element Analyses for the ultimate strength are compared with the in-house program using Smith’s method implemented in HULLST. The stress distribution and deformation for every case of damages including intact are also discussed in the present study.

Handling Qualities Evaluations of Low Complexity Model Reference Adaptive Controllers for Reduced Pitch and Roll Damping Scenarios

NASA Technical Reports Server (NTRS)

Hanson, Curt; Schaefer, Jacob; Burken, John J.; Johnson, Marcus; Nguyen, Nhan

2011-01-01

National Aeronautics and Space Administration (NASA) researchers have conducted a series of flight experiments designed to study the effects of varying levels of adaptive controller complexity on the performance and handling qualities of an aircraft under various simulated failure or damage conditions. A baseline, nonlinear dynamic inversion controller was augmented with three variations of a model reference adaptive control design. The simplest design consisted of a single adaptive parameter in each of the pitch and roll axes computed using a basic gradient-based update law. A second design was built upon the first by increasing the complexity of the update law. The third and most complex design added an additional adaptive parameter to each axis. Flight tests were conducted using NASA s Full-scale Advanced Systems Testbed, a highly modified F-18 aircraft that contains a research flight control system capable of housing advanced flight controls experiments. Each controller was evaluated against a suite of simulated failures and damage ranging from destabilization of the pitch and roll axes to significant coupling between the axes. Two pilots evaluated the three adaptive controllers as well as the non-adaptive baseline controller in a variety of dynamic maneuvers and precision flying tasks designed to uncover potential deficiencies in the handling qualities of the aircraft, and adverse interactions between the pilot and the adaptive controllers. The work was completed as part of the Integrated Resilient Aircraft Control Project under NASA s Aviation Safety Program.

Bayesian nonlinear structural FE model and seismic input identification for damage assessment of civil structures

NASA Astrophysics Data System (ADS)

Astroza, Rodrigo; Ebrahimian, Hamed; Li, Yong; Conte, Joel P.

2017-09-01

A methodology is proposed to update mechanics-based nonlinear finite element (FE) models of civil structures subjected to unknown input excitation. The approach allows to jointly estimate unknown time-invariant model parameters of a nonlinear FE model of the structure and the unknown time histories of input excitations using spatially-sparse output response measurements recorded during an earthquake event. The unscented Kalman filter, which circumvents the computation of FE response sensitivities with respect to the unknown model parameters and unknown input excitations by using a deterministic sampling approach, is employed as the estimation tool. The use of measurement data obtained from arrays of heterogeneous sensors, including accelerometers, displacement sensors, and strain gauges is investigated. Based on the estimated FE model parameters and input excitations, the updated nonlinear FE model can be interrogated to detect, localize, classify, and assess damage in the structure. Numerically simulated response data of a three-dimensional 4-story 2-by-1 bay steel frame structure with six unknown model parameters subjected to unknown bi-directional horizontal seismic excitation, and a three-dimensional 5-story 2-by-1 bay reinforced concrete frame structure with nine unknown model parameters subjected to unknown bi-directional horizontal seismic excitation are used to illustrate and validate the proposed methodology. The results of the validation studies show the excellent performance and robustness of the proposed algorithm to jointly estimate unknown FE model parameters and unknown input excitations.

[Preventive measures against health damage due to chemicals in household products].

PubMed

Kaniwa, Masa-aki

2006-01-01

Chemicals in household products have been paid much attention as main cause of health damage on consumers, such as allergic contact dermatitis. Preventive measures against health damage due to chemicals in fabric, plastic and rubber products for household uses, are reviewed, focusing on (1) regulation and voluntary control by manufacturers, (2) incidence of health damage from household products, (3) causative product-chemical investigation, (4) case studies on skin damage and respiratory tract damage.

Performance of casings in Cerro Prieto production wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dominguez A, B.; Vital B, F.; Bermejo M, F.

A careful evaluation of different production casings used at Cerro Prieto from 1964 to date has shown that the following casings have yielded particularly impressive results: 7 5/8-in. diameter, J-55, 26 lb/ft; 7 5/8-in. diameter, K-55, 45.3 lb/ft; and 5-in. diameter, K-55, 23.2 lb/ft. These casings differ from others of the same diameter but lighter weight which were also used at the field. The results are favorable in spite of severe construction problems, especially the loss of circulation during cementing operations, which we encountered in some of the wells where these casings were used. The use of gravity-fed fine sandmore » as packing material and the arrangement of the production and intermediate casings were important in avoiding damage due to tension-compression stresses and, above all, damage due to internal or external corrosion over time. This situation is clearly evidenced if we compare the damage to the above casings with that experienced by grade N-80 production casings, especially in a corrosive environment.« less

Experimental Validation of Normalized Uniform Load Surface Curvature Method for Damage Localization

PubMed Central

Jung, Ho-Yeon; Sung, Seung-Hoon; Jung, Hyung-Jo

2015-01-01

In this study, we experimentally validated the normalized uniform load surface (NULS) curvature method, which has been developed recently to assess damage localization in beam-type structures. The normalization technique allows for the accurate assessment of damage localization with greater sensitivity irrespective of the damage location. In this study, damage to a simply supported beam was numerically and experimentally investigated on the basis of the changes in the NULS curvatures, which were estimated from the modal flexibility matrices obtained from the acceleration responses under an ambient excitation. Two damage scenarios were considered for the single damage case as well as the multiple damages case by reducing the bending stiffness (EI) of the affected element(s). Numerical simulations were performed using MATLAB as a preliminary step. During the validation experiments, a series of tests were performed. It was found that the damage locations could be identified successfully without any false-positive or false-negative detections using the proposed method. For comparison, the damage detection performances were compared with those of two other well-known methods based on the modal flexibility matrix, namely, the uniform load surface (ULS) method and the ULS curvature method. It was confirmed that the proposed method is more effective for investigating the damage locations of simply supported beams than the two conventional methods in terms of sensitivity to damage under measurement noise. PMID:26501286

Foveal damage in habitual poppers users.

PubMed

Audo, Isabelle; El Sanharawi, Mohamed; Vignal-Clermont, Catherine; Villa, Antoine; Morin, Annie; Conrath, John; Fompeydie, Dominique; Sahel, José-Alain; Gocho-Nakashima, Kiyoko; Goureau, Olivier; Paques, Michel

2011-06-01

To describe foveal damage in habitual use of poppers, a popular recreational drug. Retrospective observational case series. Six patients with bilateral vision loss after chronic popper inhalation were seen in 4 university-based ophthalmology departments. Symptoms, medical history, ophthalmic examination, and functional and morphological tests are described. All patients experienced progressive bilateral vision loss, with central photopsia in 2 cases. Initial visual acuities ranged from 20/50 to 20/25. In all patients, a bilateral yellow foveal spot was present that, by optical coherence tomography, was associated with disruption of the outer segments of foveal cones. Functional and anatomical damage was restricted to the fovea. The poppers involved were identified as isopropyl nitrite in 3 cases. Four patients showed anatomical and/or functional improvement over several months after discontinuing popper inhalation. Repeated inhalation of poppers may be associated with prolonged bilateral vision loss due to the disruption of foveal cone outer segments. Retinal damage may progressively improve following drug discontinuation.

2017 One‐year seismic‐hazard forecast for the central and eastern United States from induced and natural earthquakes

USGS Publications Warehouse

Petersen, Mark D.; Mueller, Charles; Moschetti, Morgan P.; Hoover, Susan M.; Shumway, Allison; McNamara, Daniel E.; Williams, Robert; Llenos, Andrea L.; Ellsworth, William L.; Rubinstein, Justin L.; McGarr, Arthur F.; Rukstales, Kenneth S.

2017-01-01

We produce a one‐year 2017 seismic‐hazard forecast for the central and eastern United States from induced and natural earthquakes that updates the 2016 one‐year forecast; this map is intended to provide information to the public and to facilitate the development of induced seismicity forecasting models, methods, and data. The 2017 hazard model applies the same methodology and input logic tree as the 2016 forecast, but with an updated earthquake catalog. We also evaluate the 2016 seismic‐hazard forecast to improve future assessments. The 2016 forecast indicated high seismic hazard (greater than 1% probability of potentially damaging ground shaking in one year) in five focus areas: Oklahoma–Kansas, the Raton basin (Colorado/New Mexico border), north Texas, north Arkansas, and the New Madrid Seismic Zone. During 2016, several damaging induced earthquakes occurred in Oklahoma within the highest hazard region of the 2016 forecast; all of the 21 moment magnitude (M) ≥4 and 3 M≥5 earthquakes occurred within the highest hazard area in the 2016 forecast. Outside the Oklahoma–Kansas focus area, two earthquakes with M≥4 occurred near Trinidad, Colorado (in the Raton basin focus area), but no earthquakes with M≥2.7 were observed in the north Texas or north Arkansas focus areas. Several observations of damaging ground‐shaking levels were also recorded in the highest hazard region of Oklahoma. The 2017 forecasted seismic rates are lower in regions of induced activity due to lower rates of earthquakes in 2016 compared with 2015, which may be related to decreased wastewater injection caused by regulatory actions or by a decrease in unconventional oil and gas production. Nevertheless, the 2017 forecasted hazard is still significantly elevated in Oklahoma compared to the hazard calculated from seismicity before 2009.

Development of Improved Composite Pressure Vessels for Hydrogen Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newhouse, Norman L.

2016-04-29

Hexagon Lincoln started this DOE project as part of the Hydrogen Storage Engineering Center of Excellence (HSECoE) contract on 1 February 2009. The purpose of the HSECoE was the research and development of viable material based hydrogen storage systems for on-board vehicular applications to meet DOE performance and cost targets. A baseline design was established in Phase 1. Studies were then conducted to evaluate potential improvements, such as alternate fiber, resin, and boss materials. The most promising concepts were selected such that potential improvements, compared with the baseline Hexagon Lincoln tank, resulted in a projected weight reduction of 11 percent,more » volume increase of 4 percent, and cost reduction of 10 percent. The baseline design was updated in Phase 2 to reflect design improvements and changes in operating conditions specified by HSECoE Partners. Evaluation of potential improvements continued during Phase 2. Subscale prototype cylinders were designed and fabricated for HSECoE Partners’ use in demonstrating their components and systems. Risk mitigation studies were conducted in Phase 3 that focused on damage tolerance of the composite reinforcement. Updated subscale prototype cylinders were designed and manufactured to better address the HSECoE Partners’ requirements for system demonstration. Subscale Type 1, Type 3, and Type 4 tanks were designed, fabricated and tested. Laboratory tests were conducted to evaluate vacuum insulated systems for cooling the tanks during fill, and maintaining low temperatures during service. Full scale designs were prepared based on results from the studies of this program. The operating conditions that developed during the program addressed adsorbent systems operating at cold temperatures. A Type 4 tank would provide the lowest cost and lightest weight, particularly at higher pressures, as long as issues with liner compatibility and damage tolerance could be resolved. A Type 1 tank might be the choice if the liner and damage tolerance issues were not resolved, particularly if the operating pressure was reduced.« less

Aircraft Mishap Exercise at SLF

NASA Image and Video Library

2018-02-14

An Aircraft Mishap Preparedness and Contingency Plan is underway at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The center's Flight Operations rehearsed a helicopter crash-landing to test new and updated emergency procedures. The operation was designed to validate several updated techniques the center's first responders would follow, should they ever need to rescue a crew in case of a real accident. The mishap exercise took place at the center's Shuttle Landing Facility.

Damage-mitigating control of a reusable rocket engine for high performance and extended life

NASA Technical Reports Server (NTRS)

Ray, Asok; Dai, Xiaowen

1995-01-01

The goal of damage mitigating control in reusable rocket engines is to achieve high performance with increased durability of mechanical structures such that functional lives of the critical components are increased. The major benefit is an increase in structural durability with no significant loss of performance. This report investigates the feasibility of damage mitigating control of reusable rocket engines. Phenomenological models of creep and thermo-mechanical fatigue damage have been formulated in the state-variable setting such that these models can be combined with the plant model of a reusable rocket engine, such as the Space Shuttle Main Engine (SSME), for synthesizing an optimal control policy. Specifically, a creep damage model of the main thrust chamber wall is analytically derived based on the theories of sandwich beam and viscoplasticity. This model characterizes progressive bulging-out and incremental thinning of the coolant channel ligament leading to its eventual failure by tensile rupture. The objective is to generate a closed form solution of the wall thin-out phenomenon in real time where the ligament geometry is continuously updated to account for the resulting deformation. The results are in agreement with those obtained from the finite element analyses and experimental observation for both Oxygen Free High Conductivity (OFHC) copper and a copper-zerconium-silver alloy called NARloy-Z. Due to its computational efficiency, this damage model is suitable for on-line applications of life prediction and damage mitigating control, and also permits parametric studies for off-line synthesis of damage mitigating control systems. The results are presented to demonstrate the potential of life extension of reusable rocket engines via damage mitigating control. The control system has also been simulated on a testbed to observe how the damage at different critical points can be traded off without any significant loss of engine performance. The research work reported here is built upon concepts derived from the disciplines of Controls, Thermo-fluids, Structures, and Materials. The concept of damage mitigation, as presented in this report, is not restricted to control of rocket engines. It can be applied to any system where structural durability is an important issue.

Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: oral NSAID-induced corneal damage.

PubMed

Masuda, Ikuya; Matsuo, Toshihiko; Okamoto, Kazuo; Matsushita, Kyoko; Ohtsuki, Hiroshi

2010-01-01

To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs). In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively. After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively. It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.

[Preventive measures against health damage due to chemicals in household products].

PubMed

Kaniwa, Masa-aki

2010-01-01

Chemicals in household products have been paid much attention as the main cause of health damage in consumers, such as allergic contact dermatitis. Preventive measures against health damage due to chemicals in fabrics, plastics and rubber products for household use, are reviewed, focusing on 1) the incidence of health damage due to household products, 2) causative product-chemical investigation, and 3) case studies on skin damage.

Improved Ant Algorithms for Software Testing Cases Generation

PubMed Central

Yang, Shunkun; Xu, Jiaqi

2014-01-01

Existing ant colony optimization (ACO) for software testing cases generation is a very popular domain in software testing engineering. However, the traditional ACO has flaws, as early search pheromone is relatively scarce, search efficiency is low, search model is too simple, positive feedback mechanism is easy to porduce the phenomenon of stagnation and precocity. This paper introduces improved ACO for software testing cases generation: improved local pheromone update strategy for ant colony optimization, improved pheromone volatilization coefficient for ant colony optimization (IPVACO), and improved the global path pheromone update strategy for ant colony optimization (IGPACO). At last, we put forward a comprehensive improved ant colony optimization (ACIACO), which is based on all the above three methods. The proposed technique will be compared with random algorithm (RND) and genetic algorithm (GA) in terms of both efficiency and coverage. The results indicate that the improved method can effectively improve the search efficiency, restrain precocity, promote case coverage, and reduce the number of iterations. PMID:24883391

Damage localization and quantification of composite stratified beam Structures using residual force method

NASA Astrophysics Data System (ADS)

Behtani, A.; Bouazzouni, A.; Khatir, S.; Tiachacht, S.; Zhou, Y.-L.; Abdel Wahab, M.

2017-05-01

In this paper, the problem of using measured modal parameters to detect and locate damage in beam composite stratified structures with four layers of graphite/epoxy [0°/902°/0°] is investigated. A technique based on the residual force method is applied to composite stratified structure with different boundary conditions, the results of damage detection for several damage cases demonstrate that using residual force method as damage index, the damage location can be identified correctly and the damage extents can be estimated as well.

Impact damage in filament wound composite bottles

NASA Technical Reports Server (NTRS)

Highsmith, Alton L.

1993-01-01

Increasingly, composite materials are being used in advanced structural applications because of the significant weight savings they offer when compared to more traditional engineering materials. The higher cost of composites must be offset by the increased performance that results from reduced structural weight if these new materials are to be used effectively. At present, there is considerable interest in fabricating solid rocket motor cases out of composite materials, and capitalizing on the reduced structural weight to increase rocket performance. However, one of the difficulties that arises when composite materials are used is that composites can develop significant amounts of internal damage during low velocity impacts. Such low velocity impacts may be encountered in routine handling of a structural component like a rocket motor case. The ability to assess the reduction in structural integrity of composite motor cases that experience accidental impacts is essential if composite rocket motor cases are to be certified for manned flight. While experimental studies of the post-impact performance of filament wound composite motor cases haven been proven performed (2,3), scaling impact data from small specimens to full scale structures has proven difficult. If such a scaling methodology is to be achieved, an increased understanding of the damage processes which influence residual strength is required. The study described herein was part of an ongoing investigation of damage development and reduction of tensile strength in filament wound composites subjected to low velocity impacts. The present study, which focused on documenting the damage that develops in filament wound composites as a result of such impacts, included two distinct tasks. The first task was to experimentally assess impact damage in small, filament wound pressure bottles using x-ray radiography. The second task was to study the feasibility of using digital image processing techniques to assist in determining the 3-D distribution of damage from stereo x-ray pairs.

SWCD: a sliding window and self-regulated learning-based background updating method for change detection in videos

NASA Astrophysics Data System (ADS)

Işık, Şahin; Özkan, Kemal; Günal, Serkan; Gerek, Ömer Nezih

2018-03-01

Change detection with background subtraction process remains to be an unresolved issue and attracts research interest due to challenges encountered on static and dynamic scenes. The key challenge is about how to update dynamically changing backgrounds from frames with an adaptive and self-regulated feedback mechanism. In order to achieve this, we present an effective change detection algorithm for pixelwise changes. A sliding window approach combined with dynamic control of update parameters is introduced for updating background frames, which we called sliding window-based change detection. Comprehensive experiments on related test videos show that the integrated algorithm yields good objective and subjective performance by overcoming illumination variations, camera jitters, and intermittent object motions. It is argued that the obtained method makes a fair alternative in most types of foreground extraction scenarios; unlike case-specific methods, which normally fail for their nonconsidered scenarios.

Walking through doorways causes forgetting: environmental integration.

PubMed

Radvansky, Gabriel A; Tamplin, Andrea K; Krawietz, Sabine A

2010-12-01

Memory for objects declines when people move from one location to another (the location updating effect). However, it is unclear whether this is attributable to event model updating or to task demands. The focus here was on the degree of integration for probed-for information with the experienced environment. In prior research, the probes were verbal labels of visual objects. Experiment 1 assessed whether this was a consequence of an item-probe mismatch, as with transfer-appropriate processing. Visual probes were used to better coordinate what was seen with the nature of the memory probe. In Experiment 2, people received additional word pairs to remember, which were less well integrated with the environment, to assess whether the probed-for information needed to be well integrated. The results showed location updating effects in both cases. These data are consistent with an event cognition view that mental updating of a dynamic event disrupts memory.

Social tension as precursor of large damaging earthquake: legend or reality?

NASA Astrophysics Data System (ADS)

Molchanov, O.

2008-11-01

Using case study of earthquake (EQ) activity and war conflicts in Caucasus during 1975 2002 time interval and correlation analysis of global distribution of damaging EQs and war-related social tension during 1901 2005 period we conclude:

• There is a statistically reliable increase of social tension several years (or several months in case study) before damaging EQs,
• There is evident decrease of social tension several years after damaging EQs, probably due to society consolidation,
• Preseismic effect is absent for the large EQs in unpopulated areas,
• There is some factual background for legendary belief in Almighty retribution for social abnormal behavior.

Radiation-damage-induced phasing: a case study using UV irradiation with light-emitting diodes.

PubMed

de Sanctis, Daniele; Zubieta, Chloe; Felisaz, Franck; Caserotto, Hugo; Nanao, Max H

2016-03-01

Exposure to X-rays, high-intensity visible light or ultraviolet radiation results in alterations to protein structure such as the breakage of disulfide bonds, the loss of electron density at electron-rich centres and the movement of side chains. These specific changes can be exploited in order to obtain phase information. Here, a case study using insulin to illustrate each step of the radiation-damage-induced phasing (RIP) method is presented. Unlike a traditional X-ray-induced damage step, specific damage is introduced via ultraviolet light-emitting diodes (UV-LEDs). In contrast to UV lasers, UV-LEDs have the advantages of small size, low cost and relative ease of use.

A Case Study of the Cognitive and Behavioral Deficits of Temporal Lobe Damage in Herpes Simplex Encephalitis.

ERIC Educational Resources Information Center

Greer, Margaret K.; And Others

1989-01-01

This case study illustrates the highly significant language difficulties, marked memory deficits, and propensity for physical aggression following temporal lobe damage brought about by herpes encephalitis, and presents the usefulness of a new diagnostic measure in delineating such a variable cognitive pattern. (Author)

3D ductile crack propagation within a polycrystalline microstructure using XFEM

NASA Astrophysics Data System (ADS)

Beese, Steffen; Loehnert, Stefan; Wriggers, Peter

2018-02-01

In this contribution we present a gradient enhanced damage based method to simulate discrete crack propagation in 3D polycrystalline microstructures. Discrete cracks are represented using the eXtended finite element method. The crack propagation criterion and the crack propagation direction for each point along the crack front line is based on the gradient enhanced damage variable. This approach requires the solution of a coupled problem for the balance of momentum and the additional global equation for the gradient enhanced damage field. To capture the discontinuity of the displacements as well as the gradient enhanced damage along the discrete crack, both fields are enriched using the XFEM in combination with level sets. Knowing the crack front velocity, level set methods are used to compute the updated crack geometry after each crack propagation step. The applied material model is a crystal plasticity model often used for polycrystalline microstructures of metals in combination with the gradient enhanced damage model. Due to the inelastic material behaviour after each discrete crack propagation step a projection of the internal variables from the old to the new crack configuration is required. Since for arbitrary crack geometries ill-conditioning of the equation system may occur due to (near) linear dependencies between standard and enriched degrees of freedom, an XFEM stabilisation technique based on a singular value decomposition of the element stiffness matrix is proposed. The performance of the presented methodology to capture crack propagation in polycrystalline microstructures is demonstrated with a number of numerical examples.

Post-head-emergence frost in wheat and barley: defining the problem, assessing the damage, and identifying resistance.

PubMed

Frederiks, T M; Christopher, J T; Sutherland, M W; Borrell, A K

2015-06-01

Radiant frost is a significant production constraint to wheat (Triticum aestivum) and barley (Hordeum vulgare), particularly in regions where spring-habit cereals are grown through winter, maturing in spring. However, damage to winter-habit cereals in reproductive stages is also reported. Crops are particularly susceptible to frost once awns or spikes emerge from the protection of the flag leaf sheath. Post-head-emergence frost (PHEF) is a problem distinct from other cold-mediated production constraints. To date, useful increased PHEF resistance in cereals has not been identified. Given the renewed interest in reproductive frost damage in cereals, it is timely to review the problem. Here we update the extent and impacts of PHEF and document current management options to combat this challenge. We clarify terminology useful for discussing PHEF in relation to chilling and other freezing stresses. We discuss problems characterizing radiant frost, the environmental conditions leading to PHEF damage, and the effects of frost at different growth stages. PHEF resistant cultivars would be highly desirable, to both reduce the incidence of direct frost damage and to allow the timing of crop maturity to be managed to maximize yield potential. A framework of potential adaptation mechanisms is outlined. Clarification of these critical issues will sharpen research focus, improving opportunities to identify genetic sources for improved PHEF resistance. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Voter model with non-Poissonian interevent intervals

NASA Astrophysics Data System (ADS)

Takaguchi, Taro; Masuda, Naoki

2011-09-01

Recent analysis of social communications among humans has revealed that the interval between interactions for a pair of individuals and for an individual often follows a long-tail distribution. We investigate the effect of such a non-Poissonian nature of human behavior on dynamics of opinion formation. We use a variant of the voter model and numerically compare the time to consensus of all the voters with different distributions of interevent intervals and different networks. Compared with the exponential distribution of interevent intervals (i.e., the standard voter model), the power-law distribution of interevent intervals slows down consensus on the ring. This is because of the memory effect; in the power-law case, the expected time until the next update event on a link is large if the link has not had an update event for a long time. On the complete graph, the consensus time in the power-law case is close to that in the exponential case. Regular graphs bridge these two results such that the slowing down of the consensus in the power-law case as compared to the exponential case is less pronounced as the degree increases.

Computer modelling of cyclic deformation of high-temperature materials. Technical progress report, 1 September-30 November 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duesbery, M.S.

1993-11-30

This program aims at improving current methods of lifetime assessment by building in the characteristics of the micro-mechanisms known to be responsible for damage and failure. The broad approach entails the integration and, where necessary, augmentation of the micro-scale research results currently available in the literature into a macro-sale model with predictive capability. In more detail, the program will develop a set of hierarchically structured models at different length scales, from atomic to macroscopic, at each level taking as parametric input the results of the model at the next smaller scale. In this way the known microscopic properties can bemore » transported by systematic procedures to the unknown macro-scale region. It may mot be possible to eliminate empiricism completely, because some of the quantities involved cannot yet be estimated to the required degree of precision. In this case the aim will be at least to eliminate functional empiricism. Restriction of empiricism to the choice of parameters to be input to known functional forms permits some confidence in extrapolation procedures and has the advantage that the models can readily be updated as better estimates of the parameters become available.« less

An update on the recent literature on sickle cell bone disease.

PubMed

Osunkwo, Ifeyinwa

2013-12-01

To summarize the findings of the recent publications on sickle cell bone disease (SBD). Individuals with sickle cell disease (SCD) are living longer and develop progressive organ damage including SBD with age. Recent studies suggest alternative radiological diagnostics such as ultrasound and scintigraphy can detect and differentiate between different forms of SBD. MRI with or without diffusion-weighted sequences remains the gold standard. Case reports of cranio-orofacial SBD highlight the rarity of this presentation. Vitamin D deficiency is highly prevalent at all ages, but may not be an independent risk factor for avascular necrosis (AVN). Gene polymorphisms of the Annexin A gene may predict AVN in SCD. A recent study demonstrated reduced days with pain and improved physical activity quality of life following high-dose vitamin D therapy. The high rates of osteopenia and osteoporosis in SCD support the need for research addressing this rising public health problem. Lastly, results of total hip arthroplasty for AVN in SCD has improved significantly over time with the use of cementless prosthetic material and improved supportive care. SBD remains poorly studied. Prospective randomized studies targeting predictors, diagnostics, prevention, and treatment options for SBD are sorely needed.

Network traffic anomaly prediction using Artificial Neural Network

NASA Astrophysics Data System (ADS)

Ciptaningtyas, Hening Titi; Fatichah, Chastine; Sabila, Altea

2017-03-01

As the excessive increase of internet usage, the malicious software (malware) has also increase significantly. Malware is software developed by hacker for illegal purpose(s), such as stealing data and identity, causing computer damage, or denying service to other user[1]. Malware which attack computer or server often triggers network traffic anomaly phenomena. Based on Sophos's report[2], Indonesia is the riskiest country of malware attack and it also has high network traffic anomaly. This research uses Artificial Neural Network (ANN) to predict network traffic anomaly based on malware attack in Indonesia which is recorded by Id-SIRTII/CC (Indonesia Security Incident Response Team on Internet Infrastructure/Coordination Center). The case study is the highest malware attack (SQL injection) which has happened in three consecutive years: 2012, 2013, and 2014[4]. The data series is preprocessed first, then the network traffic anomaly is predicted using Artificial Neural Network and using two weight update algorithms: Gradient Descent and Momentum. Error of prediction is calculated using Mean Squared Error (MSE) [7]. The experimental result shows that MSE for SQL Injection is 0.03856. So, this approach can be used to predict network traffic anomaly.

SU34. A Systematic Review of Behavioral Research and Lesion Evidence for the 2-Factor Theory of Monothematic Delusions

PubMed Central

Neustadter, Eli; Pinder, Juno; Corlett, Philip

2017-01-01

Abstract Background: Two-factor theory (TFT) posits monothematic delusion formation requires damage producing delusion content (factor 1) and a deficit in belief evaluation (factor 2, posited to be localized in right frontal cortex). The purpose of the current study was 2-fold: (1) to review the behavioral data supporting TFT and (2) to assess whether locations of delusion-inducing lesions were consistent with TFT predictions: ie, common factor 1 damage within a particular monothematic delusion and common factor 2 damage across delusions. Furthermore, factor 2 damage ought to distinguish Capgras syndrome (the delusion that a previously familiar person is an imposter) from nondelusional-affective agnosia (unfamiliarity without delusion). Methods: We reviewed all papers concerned with TFT and all studies of galvanic skin response (GSR) in monothematic delusions (frequently cited as behavioral evidence for TFT). Next, we reviewed case reports of lesion-induced monothematic delusions including Capgras, Fregoli, Cotard, and somatoparaphrenia, as well as affective agnosia. We report lesion location frequencies in 12 regions of interest. Results: We found 27 articles on TFT. Only 3 contained empirical evidence (11%, all hypnosis studies): one had no direct hypothesis regarding TFT, one was inconclusive, and another failed to support TFT. We found 7 additional GSR studies of Capgras, 6 of which reported statistically significant abnormal GSR, but no effects were specific to the familiar person accused of being an imposter. One neuroimaging case study of Capgras did find fMRI correlates of perceiving the imposter in the left hemisphere. One study of somatoparaphrenia reported a GSR deficit to noxious stimuli approaching the denied limb. There were no published studies testing TFT predictions about Cotard or Fregoli. We analyzed 46 reports of lesion-induced delusions and 20 cases of affective agnosia. Right hemisphere damage was most common in monothematic delusion cases (χ2(1, N = 46) = 40.09, P < .0001). Within the right hemisphere, frontal and temporal damage were most common (46% of cases had damage in these regions). The patterns of regional codamage were not consistent within delusion contents (as factor 1 would demand). Contrary to TFT, affective agnosia was associated with bilateral frontal damage more frequently than Capgras delusion (P < .005), which calls into question a right frontal locus for factor 2. Conclusion: Overall, this study found no strong hypothesis-driven support of TFT. GSR findings often failed to account for the specificity of delusional content and no common pattern of brain damage for factor 2 emerged. However, the anatomical analysis was coarse (by dint of the data available in the case reports), and diaschesis effects (wherein damage in one region effects function of a distant region) are also potentially important.

A New Approach to Defining Human Touch Temperature Standards

NASA Technical Reports Server (NTRS)

Ungar, Eugene; Stroud, Kenneth

2010-01-01

Defining touch temperature limits for skin contact with both hot and cold objects is important to prevent pain and skin damage, which may affect task performance or become a safety concern. Pain and skin damage depend on the skin temperature during contact, which depends on the contact thermal conductance, the object's initial temperature, and its material properties. However, previous spacecraft standards have incorrectly defined touch temperature limits in terms of a single object temperature value for all materials, or have provided limited material-specific values which do not cover the gamut of likely designs. A new approach has been developed for updated NASA standards, which defines touch temperature limits in terms of skin temperature at pain onset for bare skin contact with hot and cold objects. The authors have developed an analytical verification method for safe hot and cold object temperatures for contact times from 1 second to infinity.

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma--a review.

PubMed

Bedreag, Ovidiu Horea; Rogobete, Alexandru Florin; Sarandan, Mirela; Cradigati, Alina Carmen; Papurica, Marius; Dumbuleu, Maria Corina; Chira, Alexandru Mihai; Rosu, Oana Maria; Sandesc, Dorel

2015-01-01

Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

Model correlation and damage location for large space truss structures: Secant method development and evaluation

NASA Technical Reports Server (NTRS)

Smith, Suzanne Weaver; Beattie, Christopher A.

1991-01-01

On-orbit testing of a large space structure will be required to complete the certification of any mathematical model for the structure dynamic response. The process of establishing a mathematical model that matches measured structure response is referred to as model correlation. Most model correlation approaches have an identification technique to determine structural characteristics from the measurements of the structure response. This problem is approached with one particular class of identification techniques - matrix adjustment methods - which use measured data to produce an optimal update of the structure property matrix, often the stiffness matrix. New methods were developed for identification to handle problems of the size and complexity expected for large space structures. Further development and refinement of these secant-method identification algorithms were undertaken. Also, evaluation of these techniques is an approach for model correlation and damage location was initiated.

Photodecomposition and Phototoxicity of Natural Retinoids

PubMed Central

Tolleson, William H.; Cherng, Shui-Hui; Xia, Qingsu; Boudreau, Mary; Yin, Jun Jie; Wamer, Wayne G.; Howard, Paul C.; Yu, Hongtao; Fu, Peter P.

2005-01-01

Sunlight is a known human carcinogen. Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight. However, little is known about the photodecomposition of some retinoids and the toxicity of these retinoids and their sunlight-induced photodecomposition products on skin. Thus, studies are required to test whether topical application of retinoids enhances the phototoxicity and photocarcinogenicity of sunlight and UV light. Mechanistic studies are needed to provide insight into the disposition of retinoids in vitro and on the skin, and to test thoroughly whether genotoxic damage by UV-induced radicals may participate in any toxicity of topically applied retinoids in the presence of UV light. This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1). PMID:16705812

Brain damage in fatal non-missile head injury without high intracranial pressure.

PubMed Central

Graham, D I; Lawrence, A E; Adams, J H; Doyle, D; McLellan, D R

1988-01-01

As part of a comprehensive study of brain damage in 635 fatal non-missile head injuries, the type and prevalence of brain damage occurring in the absence of high intracranial pressure were analysed. Of 71 such cases, 53 sustained their injury as a result of a road traffic accident; only 25 experienced a lucid interval. Thirty eight had a fractured skull, a mean total contusion index of 12.9 and diffuse axonal injury in 29: severe to moderate ischaemic damage was present in the cerebral cortex in 25, brain swelling in 13, and acute bacterial meningitis in nine. The prevalence and range of brain damage that may occur in the absence of high intracranial pressure are important to forensic pathologists in the medicolegal interpretation of cases of fatal head injury. PMID:3343378

Evidence-based Peer Review for Radiation Therapy - Updated Review of the Literature with a Focus on Tumour Subsite and Treatment Modality.

PubMed

Huo, M; Gorayski, P; Poulsen, M; Thompson, K; Pinkham, M B

2017-10-01

Technological advances in radiation therapy permit steep dose gradients from the target to spare normal tissue, but increase the risk of geographic miss. Suboptimal target delineation adversely affects clinical outcomes. Prospective peer review is a method for quality assurance of oncologists' radiotherapy plans. Published surveys suggest it is widely implemented. However, it may not be feasible to review every case before commencement of radiation therapy in all departments. The rate of plan changes following peer review of cases without a specific subsite or modality is typically around 10%. Stereotactic body radiation therapy, head and neck, gynaecological, gastrointestinal, haematological and lung cases are associated with higher rates of change of around 25%. These cases could thus be prioritised for peer review. Other factors may limit peer review efficacy including organisational culture, time constraints and the physical environment in which sessions are held. Recommendations for peer review endorsed by the American Society for Radiation Oncology were made available in 2013, but a number of relevant studies have been published since. Here we review and update the literature, and provide an updated suggestion for the implementation of peer review to serve as an adjunct to published guidelines. This may help practitioners evaluate their current processes and maximise the utility and effectiveness of peer review sessions. Copyright © 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Agent Communication for Dynamic Belief Update

NASA Astrophysics Data System (ADS)

Kobayashi, Mikito; Tojo, Satoshi

Thus far, various formalizations of rational / logical agent model have been proposed. In this paper, we include the notion of communication channel and belief modality into update logic, and introduce Belief Update Logic (BUL). First, we discuss that how we can reformalize the inform action of FIPA-ACL into communication channel, which represents a connection between agents. Thus, our agents can send a message only when they believe, and also there actually is, a channel between him / her and a receiver. Then, we present a static belief logic (BL) and show its soundness and completeness. Next, we develop the logic to BUL, which can update Kripke model by the inform action; in which we show that in the updated model the belief operator also satisfies K45. Thereafter, we show that every sentence in BUL can be translated into BL; thus, we can contend that BUL is also sound and complete. Furthermore, we discuss the features of CUL, including the case of inconsistent information, as well as channel transmission. Finally, we summarize our contribution and discuss some future issues.

Portuguese recommendations for the prevention, diagnosis and management of primary osteoporosis - 2018 update.

PubMed

Rodrigues, A M; Canhão, H; Marques, A; Ambrósio, C; Borges, J; Coelho, P; Costa, L; Fernandes, S; Gonçalves, I; Gonçalves, M; Guerra, M; Marques, M L; Pimenta, S; Pinto, P; Sequeira, G; Simões, E; Teixeira, L; Vaz, C; Vieira-Sousa, E; Vieira, R; Alvarenga, F; Araújo, F; Barcelos, A; Barcelos, F; Barros, R; Bernardes, M; Canas da Silva, J; Cordeiro, A; Costa, M; Cunha-Miranda, L; Cruz, M; Duarte, A C; Duarte, C; Faustino, A; Figueiredo, G; Fonseca, J E; Furtado, C; Gomes, J; Lopes, C; Mourão, A F; Oliveira, M; Pimentel-Santos, F M; Ribeiro, A; Sampaio da Nóvoa, T; Santiago, M; Silva, C; Silva-Dinis, A; Sousa, S; Tavares-Costa, J; Terroso, G; Vilar, A; Branco, J C; Tavares, V; Romeu, J C; da Silva, Jap

2018-01-01

Advances in osteoporosis (OP)case definition, treatment options, optimal therapy duration and pharmacoeconomic evidence in the national context motivated the Portuguese Society of Rheumatology (SPR) to update the Portuguese recommendations for the diagnosis and management of osteoporosis published in 2007. SPR bone diseases' working group organized meetings involving 55 participants (rheumatologists, rheumatology fellows and one OP specialist nurse) to debate and develop the document. First, the working group selected 11 pertinent clinical questions for the diagnosis and management of osteoporosis in standard clinical practice. Then, each question was investigated through literature review and draft recommendations were built through consensus. When insufficient evidence was available, recommendations were based on experts' opinion and on good clinical practice. At two national meetings, the recommendations were discussed and updated. A draft of the recommendations full text was submitted to critical review among the working group and suggestions were incorporated. A final version was circulated among all Portuguese rheumatologists before publication and the level of agreement was anonymously assessed using an online survey. The 2018 SPR recommendations provide comprehensive guidance on osteoporosis prevention, diagnosis, fracture risk assessment, pharmacological treatment initiation, therapy options and duration of treatment, based on the best available evidence. They attained desirable agreement among Portuguese rheumatologists. As more evidence becomes available, periodic revisions will be performed. Target audience and patient population: The target audience for these guidelines includes all clinicians. The target patient population includes adult Portuguese people. Intended use: These recommendations provide general guidance for typical cases. They may not be appropriate in all situations - clinicians are encouraged to consider this information together with updated evidence and their best clinical judgment in individual cases.

Application of correspondence analysis in the assessment of mine tailings dam breakage risk in the Mediterranean region.

PubMed

Salgueiro, Ana Rita; Pereira, Henrique Garcia; Rico, Maria-Teresa; Benito, Gerado; Díez-Herreo, Andrés

2008-02-01

A new statistical approach for preliminary risk evaluation of breakage in tailings dam is presented and illustrated by a case study regarding the Mediterranean region. The objective of the proposed method is to establish an empirical scale of risk, from which guidelines for prioritizing the collection of further specific information can be derived. The method relies on a historical database containing, in essence, two sets of qualitative data: the first set concerns the variables that are observable before the disaster (e.g., type and size of the dam, its location, and state of activity), and the second refers to the consequences of the disaster (e.g., failure type, sludge characteristics, fatalities categorization, and downstream range of damage). Based on a modified form of correspondence analysis, where the second set of attributes are projected as "supplementary variables" onto the axes provided by the eigenvalue decomposition of the matrix referring to the first set, a "qualitative regression" is performed, relating the variables to be predicted (contained in the second set) with the "predictors" (the observable variables). On the grounds of the previously derived relationship, the risk of breakage in a new case can be evaluated, given observable variables. The method was applied in a case study regarding a set of 13 test sites where the ranking of risk obtained was validated by expert knowledge. Once validated, the procedure was included in the final output of the e-EcoRisk UE project (A Regional Enterprise Network Decision-Support System for Environmental Risk and Disaster Management of Large-Scale Industrial Spills), allowing for a dynamic historical database updating and providing a prompt rough risk evaluation for a new case. The aim of this section of the global project is to provide a quantified context where failure cases occurred in the past for supporting analogue reasoning in preventing similar situations.

An Updated Review of Tyrosinase Inhibitors

PubMed Central

Chang, Te-Sheng

2009-01-01

Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed. PMID:19582213

New paradigms and future challenges in Radiation Oncology: An Update of Biological Targets and Technology*

PubMed Central

Liauw, Stanley L.; Connell, Philip P.; Weichselbaum, Ralph R.

2013-01-01

The primary objective of radiation oncology is to exploit the biological interaction of radiation within tissue to promote tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of radiation relies on principles of radiation physics that define how radiation energy is deposited in the body, as well as technology that facilitates accurate tumor targeting. This review will summarize the current landscape of recent biological and technological advances in radiation oncology, describe the challenges that exist, and offer potential avenues for improvement. PMID:23427246

Resolving occlusion and segmentation errors in multiple video object tracking

NASA Astrophysics Data System (ADS)

Cheng, Hsu-Yung; Hwang, Jenq-Neng

2009-02-01

In this work, we propose a method to integrate the Kalman filter and adaptive particle sampling for multiple video object tracking. The proposed framework is able to detect occlusion and segmentation error cases and perform adaptive particle sampling for accurate measurement selection. Compared with traditional particle filter based tracking methods, the proposed method generates particles only when necessary. With the concept of adaptive particle sampling, we can avoid degeneracy problem because the sampling position and range are dynamically determined by parameters that are updated by Kalman filters. There is no need to spend time on processing particles with very small weights. The adaptive appearance for the occluded object refers to the prediction results of Kalman filters to determine the region that should be updated and avoids the problem of using inadequate information to update the appearance under occlusion cases. The experimental results have shown that a small number of particles are sufficient to achieve high positioning and scaling accuracy. Also, the employment of adaptive appearance substantially improves the positioning and scaling accuracy on the tracking results.

Enumeration and extension of non-equivalent deterministic update schedules in Boolean networks.

PubMed

Palma, Eduardo; Salinas, Lilian; Aracena, Julio

2016-03-01

Boolean networks (BNs) are commonly used to model genetic regulatory networks (GRNs). Due to the sensibility of the dynamical behavior to changes in the updating scheme (order in which the nodes of a network update their state values), it is increasingly common to use different updating rules in the modeling of GRNs to better capture an observed biological phenomenon and thus to obtain more realistic models.In Aracena et al. equivalence classes of deterministic update schedules in BNs, that yield exactly the same dynamical behavior of the network, were defined according to a certain label function on the arcs of the interaction digraph defined for each scheme. Thus, the interaction digraph so labeled (update digraphs) encode the non-equivalent schemes. We address the problem of enumerating all non-equivalent deterministic update schedules of a given BN. First, we show that it is an intractable problem in general. To solve it, we first construct an algorithm that determines the set of update digraphs of a BN. For that, we use divide and conquer methodology based on the structural characteristics of the interaction digraph. Next, for each update digraph we determine a scheme associated. This algorithm also works in the case where there is a partial knowledge about the relative order of the updating of the states of the nodes. We exhibit some examples of how the algorithm works on some GRNs published in the literature. An executable file of the UpdateLabel algorithm made in Java and the files with the outputs of the algorithms used with the GRNs are available at: www.inf.udec.cl/ ∼lilian/UDE/ CONTACT: lilisalinas@udec.cl Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

"Should I Buy the Jerry's Famous Frozen Desserts' Chain?" Case Study [and] Case Study Update: Our Advice on Jerry's Famous Frozen Desserts.

ERIC Educational Resources Information Center

Finkle, Todd A.; And Others

1996-01-01

Offers a case study of a business plan in which the potential business owner examines the industry and the financial statements of the company he plans to purchase. A variety of experts give their perspectives on the situation and the authors provide a follow-up analysis. (JOW)

Pedophilia: an update on theory and practice.

PubMed

Travin, S; Bluestone, H; Coleman, E; Cullen, K; Melella, J

1985-01-01

The number of sexual attacks on children is staggering, yet it is extremely difficult to understand what effective treatments are available for the pedophile by reviewing the literature. Therefore, the authors present an update of the changing conceptualizations regarding the offenders and their victims. An overview of the currently used modalities to treat the pedophile is presented with emphasis on the promising cognitive-behavioral approach. A brief description of this approach is given with two case illustrations.

Analysis and evaluation of relative positions of mandibular third molar and mandibular canal impacts

PubMed Central

Kim, Hang-Gul

2014-01-01

Objectives This study used cone-beam computed tomography (CBCT) images to categorize the relationships between the mandibular canal and the roots and investigated the prevalence of nerve damage. Materials and Methods Through CBCT images, contact and three-dimensional positional relationships between the roots of the mandibular third molar and the mandibular canal were investigated. With this data, prevalence of nerve damage according to the presence of contact and three-dimensional positional relationships was studied. Other factors that affected the prevalence of nerve damage were also investigated. Results When the mandibular third molar and the mandibular canal were shown to have direct contact in CBCT images, the prevalence of nerve damage was higher than in other cases. Also, in cases where the mandibular canal was horizontally lingual to the mandibular third molar and the mandibular canal was vertically at the cervical level of the mandibular third molar, the prevalence of nerve damage was higher than in opposite cases. The percentage of mandibular canal contact with the roots of the mandibular third molar was higher when the mandibular canal was horizontally lingual to the mandibular third molar. Finally, the prevalence of nerve damage was higher when the diameter of the mandibular canal lumen suddenly decreased at the contact area between the mandibular canal and the roots, as shown in CBCT images. Conclusion The three-dimensional relationship of the mandibular third molar and the mandibular canal can help predict nerve damage and can guide patient expectations of the possibility and extent of nerve damage. PMID:25551092

Update on B-cell targeted therapies for systemic lupus erythematosus.

PubMed

Mok, Chi Chiu

2014-06-01

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by flares and remission, leading to accrual of organ damage over time as a result of persistent tissue inflammation and treatment-related complications. Novel therapies aiming at better treatment response and fewer adverse effects are being tested in the pipeline. This review summarizes the B-cell abnormalities observed in patients with SLE, and updates recent data on the efficacy and safety of B-cell targeted therapies in the treatment of SLE. The pitfalls of clinical trial design and future directions of the development of SLE therapeutics are discussed. The variability of clinical response to treatment in SLE reflects the clinical and immunological heterogeneity of the disease. The treatment plan for patients with SLE should be individualized with the aim of eradicating disease activity, preventing flares and minimizing treatment-related complications. Despite the disappointment of recent clinical trials, B-cell remains the promising target of future SLE therapies. Results from ongoing clinical trials on B-cell targeted biological agents are eagerly awaited.

Update on the approach of urinary tract infection in childhood.

PubMed

Simões e Silva, Ana Cristina; Oliveira, Eduardo Araújo

2015-01-01

Urinary tract infection (UTI) is the most common bacterial infection in childhood. UTI may be the sentinel event for underlying renal abnormality. There are still many controversies regarding proper management of UTI. In this review article, the authors discuss recent recommendations for the diagnosis, treatment, prophylaxis, and imaging of UTI in childhood based on evidence, and when this is lacking, based on expert consensus. Data were obtained after a review of the literature and a search of Pubmed, Embase, Scopus, and Scielo. In the first year of life, UTIs are more common in boys (3.7%) than in girls (2%). Signs and symptoms of UTI are very nonspecific, especially in neonates and during childhood; in many cases, fever is the only symptom. Clinical history and physical examination may suggest UTI, but confirmation should be made by urine culture, which must be performed before any antimicrobial agent is given. During childhood, the proper collection of urine is essential to avoid false-positive results. Prompt diagnosis and initiation of treatment is important to prevent long-term renal scarring. Febrile infants with UTIs should undergo renal and bladder ultrasonography. Intravenous antibacterial agents are recommended for neonates and young infants. The authors also advise exclusion of obstructive uropathies as soon as possible and later vesicoureteral reflux, if indicated. Prophylaxis should be considered for cases of high susceptibility to UTI and high risk of renal damage. Copyright © 2015 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Categorizing natural disaster damage assessment using satellite-based geospatial techniques

USGS Publications Warehouse

Myint, S.W.; Yuan, M.; Cerveny, R.S.; Giri, C.

2008-01-01

Remote sensing of a natural disaster's damage offers an exciting backup and/or alternative to traditional means of on-site damage assessment. Although necessary for complete assessment of damage areas, ground-based damage surveys conducted in the aftermath of natural hazard passage can sometimes be potentially complicated due to on-site difficulties (e.g., interaction with various authorities and emergency services) and hazards (e.g., downed power lines, gas lines, etc.), the need for rapid mobilization (particularly for remote locations), and the increasing cost of rapid physical transportation of manpower and equipment. Satellite image analysis, because of its global ubiquity, its ability for repeated independent analysis, and, as we demonstrate here, its ability to verify on-site damage assessment provides an interesting new perspective and investigative aide to researchers. Using one of the strongest tornado events in US history, the 3 May 1999 Oklahoma City Tornado, as a case example, we digitized the tornado damage path and co-registered the damage path using pre- and post-Landsat Thematic Mapper image data to perform a damage assessment. We employed several geospatial approaches, specifically the Getis index, Geary's C, and two lacunarity approaches to categorize damage characteristics according to the original Fujita tornado damage scale (F-scale). Our results indicate strong relationships between spatial indices computed within a local window and tornado F-scale damage categories identified through the ground survey. Consequently, linear regression models, even incorporating just a single band, appear effective in identifying F-scale damage categories using satellite imagery. This study demonstrates that satellite-based geospatial techniques can effectively add spatial perspectives to natural disaster damages, and in particular for this case study, tornado damages.

Categorizing natural disaster damage assessment using satellite-based geospatial techniques

NASA Astrophysics Data System (ADS)

Myint, S. W.; Yuan, M.; Cerveny, R. S.; Giri, C.

2008-07-01

Remote sensing of a natural disaster's damage offers an exciting backup and/or alternative to traditional means of on-site damage assessment. Although necessary for complete assessment of damage areas, ground-based damage surveys conducted in the aftermath of natural hazard passage can sometimes be potentially complicated due to on-site difficulties (e.g., interaction with various authorities and emergency services) and hazards (e.g., downed power lines, gas lines, etc.), the need for rapid mobilization (particularly for remote locations), and the increasing cost of rapid physical transportation of manpower and equipment. Satellite image analysis, because of its global ubiquity, its ability for repeated independent analysis, and, as we demonstrate here, its ability to verify on-site damage assessment provides an interesting new perspective and investigative aide to researchers. Using one of the strongest tornado events in US history, the 3 May 1999 Oklahoma City Tornado, as a case example, we digitized the tornado damage path and co-registered the damage path using pre- and post-Landsat Thematic Mapper image data to perform a damage assessment. We employed several geospatial approaches, specifically the Getis index, Geary's C, and two lacunarity approaches to categorize damage characteristics according to the original Fujita tornado damage scale (F-scale). Our results indicate strong relationships between spatial indices computed within a local window and tornado F-scale damage categories identified through the ground survey. Consequently, linear regression models, even incorporating just a single band, appear effective in identifying F-scale damage categories using satellite imagery. This study demonstrates that satellite-based geospatial techniques can effectively add spatial perspectives to natural disaster damages, and in particular for this case study, tornado damages.

To Your Health: NLM update transcript - Why US diplomats in Cuba became ill

MedlinePlus

... Havana embassy. Most of the diplomats in the case study were assessed from five to seven months after ... over the course of months, and, in many cases, after receiving rehabilitative therapies' (end of quote). Similarly, the study's three authors explain most of the impacted workers ...

75 FR 72777 - Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS Case 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... RIN 0750-AG62 Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS... Defense Federal Acquisition Regulation Supplement (DFARS) to update text on patents, data, and copyrights... selecting ``Search.'' Select the link ``Submit a Comment'' that corresponds with ``DFARS Case 2010-D001...

[Histomorphology of the liver by damage with phenolisatine-containing laxatives (Recurrent chronic cholangiohepatitis)].

PubMed

Lüders, C J; Riske, W E; Henning, H; Vogel, H M

1975-01-01

In the case of 36 female patients who were anamnestically known to have taken laxatives, semiquantitative histological investigations with laparoscopically obtained liver needle biopsies were effected after the exposition with preparations containing phenolisatine. The time gap until exposition was 12 to 24 h (16 cases), 48 h (8 cases), 72 to 96 h (4 cases) and 7 to 14 days (4 cases). The histological result after the exposition is an acute cholangiolitis of the allergic-hyperergic type with edema and a dense eosinophile infiltration of the portal fields with destruction of the epithelium of preformed bile ducts and portally proliferated ductles. In addition, the parenchyma of the liver shows a pleomorphism of the cells in form and colour with a cellular edema and with disseminated acidophilic necroses and necrobioses of the individual cells as well as with little reactive proliferation of the Kupffer's cell. After a period of 8 days the acute process has more or less subsided. Also, in the majority of cases there are histological signs of an aggressive chronic hepatitis of type IIa, partially in the active stage with piece-meal necroses and partially stabilized or in the process of healing. A transition to the picture of hepatitic cirrhosis is possible. In serious cases the picture of a chronic non-purulent destructive cholangitis can be simulated by the hepatocellular and canalicular damage. Thirty-one bioptic pre-examinations from the same results, whereby the acute cholangiolitical exacerbation can be attributed to an exposition of the patients themselves. The clinical picture of the phenolisatine damage in its entirety is induced by medication and is described as a recurrent chronic cholangiohepatitis. Similarities exist between the liver damages caused by chlorpromazine and arsphenamine. When medication is discontinued, the morphologic substrate recedes leaving behind an inactive fibrosis or cirrhosis. The formal and known causal pathogenetic connections are discussed with regard to this clinically important liver disease. Guidelines are then given for histological diagnosis of this damage caused by medication. 14% of the female patients with a histological picture of aggressive chronic hepatitis and hepatitic cirrhosis are affected by this type of liver damage.

Spatial problem-solving in a wheel-shaped maze: quantitative and qualitative analyses of the behavioural changes following damage to the hippocampus in the rat.

PubMed

Buhot, M C; Chapuis, N; Scardigli, P; Herrmann, T

1991-07-01

The behaviour of sham-operated rats and rats with damage to the dorsal hippocampus was compared in a complex spatial problem-solving task using a 'hub-spoke-rim' wheel type maze. Compared to the classical Olton 8-arm radial maze and Morris water maze, this apparatus presents the animal with a series of possible alternative routes both direct and indirect to the goal (food). The task included 3 main stages: exploration, feeding and testing, as do the classic problem-solving tasks. During exploration, hippocampal rats were found to be more active than sham rats. Nevertheless, they displayed habituation and a relatively efficient circumnavigation, though, in both cases, different from those of sham rats. During test trials, hippocampal rats were characterized as being less accurate, making more errors than sham rats. Nevertheless, both groups increased their accuracy of first choices over trials. The qualitative analyses of test trial performance indicated that hippocampal rats were less accurate in terms of the initial error's deviation from the goal, and less efficient in terms of corrective behaviour than sham rats which used either the periphery or the spokes to attain economically the goal. Surprisingly, hippocampal rats were not limited to a taxon type orientation but learned to use the periphery, a tendency which developed over time. Seemingly, for sham rats, the problem-solving process took the form of updating information during transit. For hippocampal rats, the use of periphery reflected both an ability to discriminate its usefulness in reaching the goal via a taxis type behaviour, and some sparing of ability to generalize the closeness and the location of the goal. These results, especially the strategic correction patterns, are discussed in the light of Sutherland and Rudy's 'configurational association theory'.

Contemporary epidemiological overview of malaria in Madagascar: operational utility of reported routine case data for malaria control planning.

PubMed

Howes, Rosalind E; Mioramalala, Sedera Aurélien; Ramiranirina, Brune; Franchard, Thierry; Rakotorahalahy, Andry Joeliarijaona; Bisanzio, Donal; Gething, Peter W; Zimmerman, Peter A; Ratsimbasoa, Arsène

2016-10-18

Malaria remains a major public health problem in Madagascar. Widespread scale-up of intervention coverage has led to substantial reductions in case numbers since 2000. However, political instability since 2009 has disrupted these efforts, and a resurgence of malaria has since followed. This paper re-visits the sub-national stratification of malaria transmission across Madagascar to propose a contemporary update, and evaluates the reported routine case data reported at this sub-national scale. Two independent malariometrics were evaluated to re-examine the status of malaria across Madagascar. First, modelled maps of Plasmodium falciparum infection prevalence (PfPR) from the Malaria Atlas Project were used to update the sub-national stratification into 'ecozones' based on transmission intensity. Second, routine reports of case data from health facilities were synthesized from 2010 to 2015 to compare the sub-national epidemiology across the updated ecozones over time. Proxy indicators of data completeness are investigated. The epidemiology of malaria is highly diverse across the island's ecological regions, with eight contiguous ecozones emerging from the transmission intensity PfPR map. East and west coastal areas have highest transmission year-round, contrasting with the central highlands and desert south where trends appear more closely associated with epidemic outbreak events. Ecozones have shown steady increases in reported malaria cases since 2010, with a near doubling of raw reported case numbers from 2014 to 2015. Gauges of data completeness suggest that interpretation of raw reported case numbers will underestimate true caseload as only approximately 60-75 % of health facility data are reported to the central level each month. A sub-national perspective is essential when monitoring the epidemiology of malaria in Madagascar and assessing local control needs. A robust assessment of the status of malaria at a time when intervention coverage efforts are being scaled up provides a platform from which to guide intervention preparedness and assess change in future periods of transmission.

Mathematical modeling of damage in unidirectional composites

NASA Technical Reports Server (NTRS)

Goree, J. G.; Dharani, L. R.; Jones, W. F.

1983-01-01

Extending the work of Goree and Gross (1979), solutions are given for a two-dimensional region of unidirectional fibers embedded in an elastic matrix whose initial flaw may take the form of a transverse notch, a rectangular cutout, or a circular hole. Subsequent flaw-induced damage is generated by remote stresses acting parallel to the fibers. For the case of such ductile matrix composites as boron/aluminum, present results indicate that both longitudinal matrix yielding and transverse notch extension must be included in order for the model to agree with experimental results. Little difference is found for the three types of initial damage considered. In all cases, the presence of additional damage changes the nature of stress distribution through the unbroken fibers.

Updating categorical soil maps using limited survey data by Bayesian Markov chain cosimulation.

PubMed

Li, Weidong; Zhang, Chuanrong; Dey, Dipak K; Willig, Michael R

2013-01-01

Updating categorical soil maps is necessary for providing current, higher-quality soil data to agricultural and environmental management but may not require a costly thorough field survey because latest legacy maps may only need limited corrections. This study suggests a Markov chain random field (MCRF) sequential cosimulation (Co-MCSS) method for updating categorical soil maps using limited survey data provided that qualified legacy maps are available. A case study using synthetic data demonstrates that Co-MCSS can appreciably improve simulation accuracy of soil types with both contributions from a legacy map and limited sample data. The method indicates the following characteristics: (1) if a soil type indicates no change in an update survey or it has been reclassified into another type that similarly evinces no change, it will be simply reproduced in the updated map; (2) if a soil type has changes in some places, it will be simulated with uncertainty quantified by occurrence probability maps; (3) if a soil type has no change in an area but evinces changes in other distant areas, it still can be captured in the area with unobvious uncertainty. We concluded that Co-MCSS might be a practical method for updating categorical soil maps with limited survey data.

Updating Categorical Soil Maps Using Limited Survey Data by Bayesian Markov Chain Cosimulation

PubMed Central

Dey, Dipak K.; Willig, Michael R.

2013-01-01

Updating categorical soil maps is necessary for providing current, higher-quality soil data to agricultural and environmental management but may not require a costly thorough field survey because latest legacy maps may only need limited corrections. This study suggests a Markov chain random field (MCRF) sequential cosimulation (Co-MCSS) method for updating categorical soil maps using limited survey data provided that qualified legacy maps are available. A case study using synthetic data demonstrates that Co-MCSS can appreciably improve simulation accuracy of soil types with both contributions from a legacy map and limited sample data. The method indicates the following characteristics: (1) if a soil type indicates no change in an update survey or it has been reclassified into another type that similarly evinces no change, it will be simply reproduced in the updated map; (2) if a soil type has changes in some places, it will be simulated with uncertainty quantified by occurrence probability maps; (3) if a soil type has no change in an area but evinces changes in other distant areas, it still can be captured in the area with unobvious uncertainty. We concluded that Co-MCSS might be a practical method for updating categorical soil maps with limited survey data. PMID:24027447

Management of iatrogenic crystalline lens injury occurred during intravitreal injection.

PubMed

Erdogan, Gurkan; Gunay, Betul Onal; Unlu, Cihan; Gunay, Murat; Ergin, Ahmet

2016-08-01

To evaluate the approach to management of iatrogenic crystalline lens injury occurred during intravitreal injection (IVI). The patients who were managed operatively or followed-up without intervention after the iatrogenic lens injury due to IVI were included in the study. Capsular breaks remained either quiescent or resulted in cataract formation in the patients with inadvertent crystalline lens capsule damage. Phacoemulsification surgery was performed in patients with cataract formation with lower fluidic settings. A total of 9 cases included in the study. Seven cases underwent phacoemulsification with intraocular lens implantation. Two cases remained as quiescent lens injury during the follow-up. In 2 cases, dislocation of lens fragments occurred during phacoemulsification where pars plana vitrectomy was performed at the same session. After iatrogenic crystalline lens injury, capsular damage could remain quiescent or progress to cataract formation. Although phacoemulsification surgery can be performed with appropriate parameters, lens fragment dislocation can be observed in cases with traumatic lens damage secondary to IVI.

[Possibilities of medical opinionating in cases associated with "exposure to direct danger of death or serious health damage"].

PubMed

Konopka, Tomasz; Skupień, Elzbieta

2008-01-01

In the opinion of some forensic medicine experts, assessment of potential consequences in keeping with Article 160 of the Polish Penal code, which refers to the crime of "exposure to direct danger of death or severe health damage", lies within the competence of medicolegal specialists. This view is accepted by courts and prosecution offices. However, the knowledge of physicians in the field of predicting consequences which did not occur is only somewhat better than that of lawyers. In simple cases, e.g. in trauma involving a sensitive area of the body, passing an opinion confirming a serious danger is not associated with any major problems. Similarly, no problems arise when passing an opinion on the lack of such a danger e.g. in the case of traumawithout any injuries. In complex cases, however, which include the majority of medical error cases, passing an opinion on exposure to direct danger of death or severe health damage may be not feasible.

[Atraumatic dislocation in mobile-bearing total knee arthroplasty: two case reports].

PubMed

Schuh, A; Hönle, W

2007-10-01

Atraumatic dislocation following total knee arthroplasty (TKA) is a rare condition. Severe complications after dislocation are lesion of the vascular-nerve bundle, compartment syndrome or amputation. The benefit of TKA with mobile-bearing are an improvement of the range of motion and better articulation. In comparison to fixed-bearing TKA there is the risk of dislocation or breakage of the polyethylene insert. We present two cases with dislocation following TKA with mobile-bearing. In both cases preoperatively there was a significant weakening of the function of the quadriceps muscle. During revision of the TKA severe damage with multiple scratches of the polyethylene onlay could be detected. The damage of the PE onlay could especially be found at the tibial aspect. Follow-up showed an uneventful course after conversion to fixed-bearing polyethylen component. In cases of dislocation following TKA with mobile-bearing operative revision is recommended to exchange the damaged PE onlay and prevent increased wear. TKA with mobile-bearing should be reserved only for cases with a good quadriceps muscle function.

Taphonomic Analysis of Rodentia and Lagomorpha Bone Gnawing Based Upon Incisor Size.

PubMed

Pokines, James T; Sussman, Rachel; Gough, Megan; Ralston, Claira; McLeod, Elizabeth; Brun, Karen; Kearns, Aisling; Moore, Tara L

2017-01-01

Rodent and lagomorph species have a worldwide distribution and have the potential to alter remains from forensic cases by gnawing soft tissue and bones and through dispersal. The present research compiled metric data on the incisors widths of all rodent and lagomorph species whose ranges include Massachusetts, U.S.A., to compare their sizes to gnawing damage found on 17 cases of human remains from the Office of the Chief Medical Examiner, Boston, MA. Data on gnawing maximum striation widths also were collected from live laboratory, zoo, and wild specimens. Gnawing damage on the forensic cases could be attributed only to a particular size class of rodent or lagomorph, and identification to a particular species based on gnawing damage alone may be possible only in relatively rare cases. Multiple species examined here have broad distribution ranges, so their taphonomic alterations may impact bones from forensic cases throughout large portions of North America. © 2016 American Academy of Forensic Sciences.

Acute organo-phosphorus pesticide poisoning in North Karnataka, India: oxidative damage, haemoglobin level and total leukocyte.

PubMed

Hundekari, I A; Suryakar, A N; Rathi, D B

2013-03-01

Pesticide poisoning is an important cause of morbidity and mortality in India. To assess the oxidative damage, hemoglobin level and leukocyte count in acute organophosphorus pesticide poisoning. Plasma cholinesterase was assessed as a toxicity marker. Oxidative damage was assessed by estimating serum malondialdehyde (MDA) levels, plasma total antioxidant capacity (TAC), erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels. Progressive and significant decline (p< 0.001) in plasma cholinesterase in correlation with the severity of organophosphorus poisoning was observed. Serum MDA levels significantly increased (p< 0.001) in all grades of organophosphorus poisoning cases as compared to controls. Erythrocyte SOD, CAT and GPx were significantly increased (p< 0.05) in earlier grade and (p< 0.001) in later grades of organophosphorus poisoning cases as compared to controls. While plasma TAC (p<0.001) was significantly decreased in all grades of organophosphorus poisoning cases as compared to controls. Leucocytosis observed in these cases signifies the activation of defense mechanism which could be a positive response for survival. Organophosphorus compounds inhibit cholinesterase action leading to cholinergic hyperactivity. Increased MDA level may lead to peroxidative damages deteriorating the structural and functional integrity of neuronal membrane. Increased erythrocyte SOD, CAT and GPx activities suggest an adaptive measure to tackle the pesticide accumulation. Hence it is concluded that cholinesterase inhibition may initiate cellular dysfunction leading to acetylcholine induced oxidative damage.

Study of VLCC tanker ship damage stability during off-shore operation

NASA Astrophysics Data System (ADS)

Hanzu-Pazara, R.; Arsenie, P.; Duse, A.; Varsami, C.

2016-08-01

Today, for the carriage of crude oil on sea are used larger tanker ships, especially from VLCC class. The operation of this type of ships requires in many cases special conditions, mainly related to water depth in the terminal area and enough maneuvering space for entrance and departure. Because, many ports from all over the world don't have capacity to operate this type of ships inside, in designed oil terminal, have chosen for development of outside terminals, off-shore oil terminals. In case of this type of terminals, the problems of water depth and manoeuvring space are fixed, but other kind of situations appears, regarding the safety in operation and environment factors impact on ship during mooring at oil transfer buoy. In the present paper we intend to show a study made using simulation techniques about VLCC class tanker ship in case of a damage condition resulted after a possible collision with another ship during loading operation at an off-shore terminal. From the beginning, we take in consideration that the ship intact stability, during all loading possible situations, has to be high enough, so that in case of some damage with flooding of different compartments due to hypothetical dimension water hole, the ship stability in the final stage of flooding to correspond to the requirements for damage stability and, also, to complementary requirements for damage ship stability.

Improving the representation of secondary organic aerosol (SOA) in the MOZART-4 global chemical transport model

NASA Astrophysics Data System (ADS)

Mahmud, A.; Barsanti, K. C.

2012-12-01

The secondary organic aerosol (SOA) module in the Model for Ozone and Related chemical Tracers, version 4 (MOZART-4) has been updated by replacing existing two-product (2p) parameters with those obtained from two-product volatility basis set (2p-VBS) fits, and by treating SOA formation from the following volatile organic compounds (VOCs): isoprene, propene and lumped alkenes. Strong seasonal and spatial variations in global SOA distributions were demonstrated, with significant differences in the predicted concentrations between the base-case and updated model versions. The base-case MOZART-4 predicted annual average SOA of 0.36 ± 0.50 μg m-3 in South America, 0.31 ± 0.38 μg m-3 in Indonesia, 0.09 ± 0.05 μg m-3 in the USA, and 0.12 ± 0.07 μg m-3 in Europe. Concentrations from the updated versions of the model showed a~marked increase in annual average SOA. Using the updated set of parameters alone (MZ4-v1) increased annual average SOA by ~8%, ~16%, ~56%, and ~108% from the base-case in South America, Indonesia, USA, and Europe, respectively. Treatment of additional parent VOCs (MZ4-v2) resulted in an even more dramatic increase of ~178-406% in annual average SOA for these regions over the base-case. The increases in predicted SOA concentrations further resulted in increases in corresponding SOA contributions to annual average total aerosol optical depth (AOD) by <1% for MZ4-v1 and ~1-6% for MZ4-v2. Estimated global SOA production was ~6.6 Tg yr-1 and ~19.1 Tg yr-1 with corresponding burdens of ~0.24 Tg and ~0.59 Tg using MZ4-v1 and MZ4-v2, respectively. The SOA budgets predicted in the current study fall well within reported ranges for similar modeling studies, 6.7 to 96 Tg yr-1, but are lower than recently reported observationally-constrained values, 50 to 380 Tg yr-1. With MZ4-v2, simulated SOA concentrations at the surface were also in reasonable agreement with comparable modeling studies and observations. Concentrations of estimated organic aerosol (OA) at the surface, however, showed under-prediction in Europe and over-prediction in the Amazonian regions and Malaysian Borneo during certain months of the year. Overall, the updated version of MOZART-4, MZ4-v2, showed consistently better skill in predicting SOA and OA levels and spatial distributions as compared with unmodified MOZART-4. The MZ4-v2 updates may be particularly important when MOZART-4 output is used to generate boundary conditions for regional air quality simulations that require more accurate representation of SOA concentrations and distributions.

Is neonatal neurological damage in the delivery room avoidable? Experience of 33 levels I and II maternity units of a French perinatal network.

PubMed

Dupuis, O; Dupont, C; Gaucherand, P; Rudigoz, R-C; Fernandez, M P; Peigne, E; Labaune, J M

2007-09-01

To determine the frequency of avoidable neonatal neurological damage. We carried out a retrospective study from January 1st to December 31st 2003, including all children transferred from a level I or II maternity unit for suspected neurological damage (SND). Only cases confirmed by a persistent abnormality on clinical examination, EEG, transfontanelle ultrasound scan, CT scan or cerebral MRI were retained. Each case was studied in detail by an expert committee and classified as "avoidable", "unavoidable" or "of indeterminate avoidability." The management of "avoidable" cases was analysed to identify potentially avoidable factors (PAFs): not taking into account a major risk factor (PAF1), diagnostic errors (PAF2), suboptimal decision to delivery interval (PAF3) and mechanical complications (PAF4). In total, 77 children were transferred for SND; two cases were excluded (inaccessible medical files). Forty of the 75 cases of SND included were confirmed: 29 were "avoidable", 8 were "unavoidable" and 3 were "of indeterminate avoidability". Analysis of the 29 avoidable cases identified 39 PAFs: 18 PAF1, 5 PAF2, 10 PAF3 and 6 PAF4. Five had no classifiable PAF (0 death), 11 children had one type of PAF (one death), 11 children had two types of PAF (3 deaths), 2 had three types of PAF (2 deaths). Three quarters of the confirmed cases of neurological damage occurring in levels I and II maternity units of the Aurore network in 2003 were avoidable. Five out of six cases resulting in early death involved several potentially avoidable factors.

RUCAM in Drug and Herb Induced Liver Injury: The Update

PubMed Central

Danan, Gaby; Teschke, Rolf

2015-01-01

RUCAM (Roussel Uclaf Causality Assessment Method) or its previous synonym CIOMS (Council for International Organizations of Medical Sciences) is a well established tool in common use to quantitatively assess causality in cases of suspected drug induced liver injury (DILI) and herb induced liver injury (HILI). Historical background and the original work confirm the use of RUCAM as single term for future cases, dismissing now the term CIOMS for reasons of simplicity and clarity. RUCAM represents a structured, standardized, validated, and hepatotoxicity specific diagnostic approach that attributes scores to individual key items, providing final quantitative gradings of causality for each suspect drug/herb in a case report. Experts from Europe and the United States had previously established in consensus meetings the first criteria of RUCAM to meet the requirements of clinicians and practitioners in care for their patients with suspected DILI and HILI. RUCAM was completed by additional criteria and validated, assisting to establish the timely diagnosis with a high degree of certainty. In many countries and for more than two decades, physicians, regulatory agencies, case report authors, and pharmaceutical companies successfully applied RUCAM for suspected DILI and HILI. Their practical experience, emerging new data on DILI and HILI characteristics, and few ambiguous questions in domains such alcohol use and exclusions of non-drug causes led to the present update of RUCAM. The aim was to reduce interobserver and intraobserver variability, to provide accurately defined, objective core elements, and to simplify the handling of the items. We now present the update of the well accepted original RUCAM scale and recommend its use for clinical, regulatory, publication, and expert purposes to validly establish causality in cases of suspected DILI and HILI, facilitating a straightforward application and an internationally harmonized approach of causality assessment as a common basic tool. PMID:26712744

Aspiration dynamics of multi-player games in finite populations

PubMed Central

Du, Jinming; Wu, Bin; Altrock, Philipp M.; Wang, Long

2014-01-01

On studying strategy update rules in the framework of evolutionary game theory, one can differentiate between imitation processes and aspiration-driven dynamics. In the former case, individuals imitate the strategy of a more successful peer. In the latter case, individuals adjust their strategies based on a comparison of their pay-offs from the evolutionary game to a value they aspire, called the level of aspiration. Unlike imitation processes of pairwise comparison, aspiration-driven updates do not require additional information about the strategic environment and can thus be interpreted as being more spontaneous. Recent work has mainly focused on understanding how aspiration dynamics alter the evolutionary outcome in structured populations. However, the baseline case for understanding strategy selection is the well-mixed population case, which is still lacking sufficient understanding. We explore how aspiration-driven strategy-update dynamics under imperfect rationality influence the average abundance of a strategy in multi-player evolutionary games with two strategies. We analytically derive a condition under which a strategy is more abundant than the other in the weak selection limiting case. This approach has a long-standing history in evolutionary games and is mostly applied for its mathematical approachability. Hence, we also explore strong selection numerically, which shows that our weak selection condition is a robust predictor of the average abundance of a strategy. The condition turns out to differ from that of a wide class of imitation dynamics, as long as the game is not dyadic. Therefore, a strategy favoured under imitation dynamics can be disfavoured under aspiration dynamics. This does not require any population structure, and thus highlights the intrinsic difference between imitation and aspiration dynamics. PMID:24598208

Aspiration dynamics of multi-player games in finite populations.

PubMed

Du, Jinming; Wu, Bin; Altrock, Philipp M; Wang, Long

2014-05-06

On studying strategy update rules in the framework of evolutionary game theory, one can differentiate between imitation processes and aspiration-driven dynamics. In the former case, individuals imitate the strategy of a more successful peer. In the latter case, individuals adjust their strategies based on a comparison of their pay-offs from the evolutionary game to a value they aspire, called the level of aspiration. Unlike imitation processes of pairwise comparison, aspiration-driven updates do not require additional information about the strategic environment and can thus be interpreted as being more spontaneous. Recent work has mainly focused on understanding how aspiration dynamics alter the evolutionary outcome in structured populations. However, the baseline case for understanding strategy selection is the well-mixed population case, which is still lacking sufficient understanding. We explore how aspiration-driven strategy-update dynamics under imperfect rationality influence the average abundance of a strategy in multi-player evolutionary games with two strategies. We analytically derive a condition under which a strategy is more abundant than the other in the weak selection limiting case. This approach has a long-standing history in evolutionary games and is mostly applied for its mathematical approachability. Hence, we also explore strong selection numerically, which shows that our weak selection condition is a robust predictor of the average abundance of a strategy. The condition turns out to differ from that of a wide class of imitation dynamics, as long as the game is not dyadic. Therefore, a strategy favoured under imitation dynamics can be disfavoured under aspiration dynamics. This does not require any population structure, and thus highlights the intrinsic difference between imitation and aspiration dynamics.

Advances in adaptive control theory: Gradient- and derivative-free approaches

NASA Astrophysics Data System (ADS)

Yucelen, Tansel

In this dissertation, we present new approaches to improve standard designs in adaptive control theory, and novel adaptive control architectures. We first present a novel Kalman filter based approach for approximately enforcing a linear constraint in standard adaptive control design. One application is that this leads to alternative forms for well known modification terms such as e-modification. In addition, it leads to smaller tracking errors without incurring significant oscillations in the system response and without requiring high modification gain. We derive alternative forms of e- and adaptive loop recovery (ALR-) modifications. Next, we show how to use Kalman filter optimization to derive a novel adaptation law. This results in an optimization-based time-varying adaptation gain that reduces the need for adaptation gain tuning. A second major contribution of this dissertation is the development of a novel derivative-free, delayed weight update law for adaptive control. The assumption of constant unknown ideal weights is relaxed to the existence of time-varying weights, such that fast and possibly discontinuous variation in weights are allowed. This approach is particulary advantageous for applications to systems that can undergo a sudden change in dynamics, such as might be due to reconfiguration, deployment of a payload, docking, or structural damage, and for rejection of external disturbance processes. As a third and final contribution, we develop a novel approach for extending all the methods developed in this dissertation to the case of output feedback. The approach is developed only for the case of derivative-free adaptive control, and the extension of the other approaches developed previously for the state feedback case to output feedback is left as a future research topic. The proposed approaches of this dissertation are illustrated in both simulation and flight test.

Herb-Induced Liver Injuries in Developing Nations: An Update.

PubMed

Amadi, Cecilia Nwadiuto; Orisakwe, Orish Ebere

2018-04-17

The last few decades have seen a rise in the use of herbal supplements, natural products, and traditional medicines. However, there are growing concerns related to the safety and toxicities of these medicines. These herbal medicines are associated with complications such as liver damage with a high incidence of mortalities and morbidities. Clinical manifestations range from asymptomatic cases with abnormal liver functions tests to sudden and severe liver failure necessitating liver transplantation. This work aimed to review the etiology, risk factors, diagnosis, clinical manifestations and selected clinical case reports of herbal hepatotoxicity in developing nations. PubMed and Google Scholar searches were undertaken to identify relevant literature. Furthermore, we scanned the reference lists of the primary and review articles to identify publications not retrieved by electronic searches. Little data exists on clinical cases of herb-induced liver injury in some developing countries such as Nigeria, as most incidences are either not reported to health care providers or reports from hospitals go unpublished. Studies in Nigeria have highlighted a possible correlation between use of herbs and liver disease. In Uganda, and association between the use of traditional herbal medicine with liver fibrosis in HIV-infected and non-HIV patients was demonstrated. Reports from China have revealed incidences of acute liver failure as a result of herbal medicine use. The actual incidence and prevalence of HILI in developing nations remain largely unknown due to both poor pharmacovigilance programs and non-application of emerging technologies. Improving education and public awareness of the potential risks of herbals and herbal products is desirable to ensure that suspected adverse effects are formally reported. There is need for stricter regulations and pre-clinical studies necessary for efficacy and safety.

Brain hemorrhage after electrical burn injury: Case report and probable mechanism.

PubMed

Axayacalt, Gutierrez Aceves Guillermo; Alejandro, Ceja Espinosa; Marcos, Rios Alanis; Inocencio, Ruiz Flores Milton; Alfredo, Herrera Gonzalez Jose

2016-01-01

High-voltage electric injury may induce lesion in different organs. In addition to the local tissue damage, electrical injuries may lead to neurological deficits, musculoskeletal damage, and cardiovascular injury. Severe vascular damage may occur making the blood vessels involved prone to thrombosis and spontaneous rupture. Here, we present the case of a 39-year-old male who suffered an electrical burn with high tension wire causing intracranial bleeding. He presented with an electrical burn in the parietal area (entry zone) and the left forearm (exit zone). The head tomography scan revealed an intraparenchimatous bleeding in the left parietal area. In this case, the electric way was the scalp, cranial bone, blood vessels and brain, upper limb muscle, and skin. The damage was different according to the dielectric property in each tissue. The injury was in the scalp, cerebral blood vessel, skeletal muscle, and upper limb skin. The main damage was in brain's blood vessels because of the dielectric and geometric features that lead to bleeding, high temperature, and gas delivering. This is a report of a patient with an electric brain injury that can be useful to elucidate the behavior of the high voltage electrical current flow into the nervous system.

The effect of lamination-induced stresses on fatigue damage development at internal flaws

NASA Technical Reports Server (NTRS)

Reifsnider, K. L.

1981-01-01

The effects of stresses induced by the lamination of off-axis plies to O-deg lamina on the development of damage during the fatigue loading of the O-deg plies are discussed. The transverse normal stresses in the plane of the laminae and the laminate created by the laminating constraints when an axial force is applied to the laminate are calculated in terms of a differential Poisson ratio between the ply in question in the unconstrained and constrained states, and significant differences in the constraint environments of an unnotched specimen joined to plies of 45 and 90 deg inclination are noted which correspond to an increase in longitudinal splitting in the 90 deg case and a marked decrease in longitudinal splitting in the 45 deg case. If a notch is present, shear and crack-opening damage is found to be very effectively suppressed in 45-deg laminates, and less so in the 90-deg case. It is pointed out that whereas the 45-deg laminate represents the least damage situation, it does not have the greatest notched strength. It is concluded that an understanding and prediction of damage development in laminates requires knowledge of the stress fields caused by the lamination constraints.

ShakeCast: Automating and Improving the Use of ShakeMap for Post-Earthquake Decision- Making and Response

NASA Astrophysics Data System (ADS)

Lin, K.; Wald, D. J.

2007-12-01

ShakeCast is a freely available, post-earthquake situational awareness application that automatically retrieves earthquake shaking data from ShakeMap, compares intensity measures against users" facilities, sends notifications of potential damage to responsible parties, and generates facility damage maps and other Web-based products for emergency managers and responders. ShakeMap, a tool used to portray the extent of potentially damaging shaking following an earthquake, provides overall information regarding the affected areas. When a potentially damaging earthquake occurs, utility and other lifeline managers, emergency responders, and other critical users have an urgent need for information about the impact on their particular facilities so they can make appropriate decisions and take quick actions to ensure safety and restore system functionality. To this end, ShakeCast estimates the potential damage to a user's widely distributed facilities by comparing the complex shaking distribution with the potentially highly variable damageability of their inventory to provide a simple, hierarchical list and maps showing structures or facilities most likely impacted. All ShakeMap and ShakeCast files and products are non-propriety to simplify interfacing with existing users" response tools and to encourage user-made enhancement to the software. ShakeCast uses standard RSS and HTTP requests to communicate with the USGS Web servers that host ShakeMaps, which are widely-distributed and heavily mirrored. The RSS approach allows ShakeCast users to initiate and receive selected ShakeMap products and information on software updates. To assess facility damage estimates, ShakeCast users can combine measured or estimated ground motion parameters with damage relationships that can be pre-computed, use one of these ground motion parameters as input, and produce a multi-state discrete output of damage likelihood. Presently three common approaches are being used to provide users with an indication of damage: HAZUS-based, intensity-based, and customized damage functions. Intensity-based thresholds are for locations with poorly established damage relationships; custom damage levels are for advanced ShakeCast users such as Caltrans which produces its own set of damage functions that correspond to the specific details of each California bridge or overpass in its jurisdiction. For users whose portfolio of structures is comprised of common, standard designs, ShakeCast offers a simplified structural damage-state estimation capability adapted from the HAZUS-MH earthquake module (NIBS and FEMA, 2003). Currently the simplified fragility settings consist of 128 combinations of HAZUS model building types, construction materials, building heights, and building-code eras.

Bumper 3 Update for IADC Protection Manual

NASA Technical Reports Server (NTRS)

Christiansen, Eric L.; Nagy, Kornel; Hyde, Jim

2016-01-01

The Bumper code has been the standard in use by NASA and contractors to perform meteoroid/debris risk assessments since 1990. It has undergone extensive revisions and updates [NASA JSC HITF website; Christiansen et al., 1992, 1997]. NASA Johnson Space Center (JSC) has applied BUMPER to risk assessments for Space Station, Shuttle, Mir, Extravehicular Mobility Units (EMU) space suits, and other spacecraft (e.g., LDEF, Iridium, TDRS, and Hubble Space Telescope). Bumper continues to be updated with changes in the ballistic limit equations describing failure threshold of various spacecraft components, as well as changes in the meteoroid and debris environment models. Significant efforts are expended to validate Bumper and benchmark it to other meteoroid/debris risk assessment codes. Bumper 3 is a refactored version of Bumper II. The structure of the code was extensively modified to improve maintenance, performance and flexibility. The architecture was changed to separate the frequently updated ballistic limit equations from the relatively stable common core functions of the program. These updates allow NASA to produce specific editions of the Bumper 3 that are tailored for specific customer requirements. The core consists of common code necessary to process the Micrometeoroid and Orbital Debris (MMOD) environment models, assess shadowing and calculate MMOD risk. The library of target response subroutines includes a board range of different types of MMOD shield ballistic limit equations as well as equations describing damage to various spacecraft subsystems or hardware (thermal protection materials, windows, radiators, solar arrays, cables, etc.). The core and library of ballistic response subroutines are maintained under configuration control. A change in the core will affect all editions of the code, whereas a change in one or more of the response subroutines will affect all editions of the code that contain the particular response subroutines which are modified. Note that the Bumper II program is no longer maintained or distributed by NASA.

Assessment of impact damage of composite rocket motor cases

NASA Technical Reports Server (NTRS)

Paris, Henry G.

1994-01-01

This contract reviewed the available literature on mechanisms of low velocity impact damage in filament wound rocket motor cases, MDE methods to quantify damage, critical coupon level test methods, manufacturing and material process variables and empirical and analytical modeling off impact damage. The critical design properties for rocket motor cases are biaxial hoop and axial tensile strength. Low velocity impact damage is insidious because it can create serious nonvisible damage at very low impact velocities. In thick rocket motor cases the prevalent low velocity impact damage is fiber fracture and matrix cracking adjacent to the front face. In contrast, low velocity loading of thin wall cylinders induces flexure, depending on span length and the flexure induces delamination and tensile cracking on the back face wall opposed to impact occurs due to flexural stresses imposed by impact loading. Important NDE methods for rocket motor cases are non-contacting methods that allow inspection from one side. Among these are vibrothermography, and pulse-echo methods based on acoustic-ultrasonic methods. High resolution techniques such as x-ray computed tomography appear to have merit for accurate geometrical characterization of local damage to support development of analytical models of micromechanics. The challenge of coupon level testing is to reproduce the biaxial stress state that the full scale article experiences, and to determine how to scale the composite structure to model full sized behavior. Biaxial tensile testing has been performed by uniaxially tensile loading internally pressurized cylinders. This is experimentally difficult due to gripping problems and pressure containment. Much prior work focused on uniaxial tensile testing of model filament wound cylinders. Interpretation of the results of some studies is complicated by the fact that the fabrication process did not duplicate full scale manufacturing. It is difficult to scale results from testing subscale cylinders since there are significant differences in out time of the resins relative to full scale cylinder fabrication, differences in hoop fiber tensioning and unsatisfactory coupon configurations. It appears that development of a new test method for subscale cylinders is merited. Damage tolerance may be improved by material optimization that uses fiber treatments and matrix modifications to control the fiber matrix interface bonding. It is difficult to develop process optimization in subscale cylinders without also modeling the longer out times resins experience in full scale testing. A major breakthrough in characterizing the effect of impact damage on residual strength, and understanding how to scale results of subscale evaluations, will be a sound micromechanical model that described progressive failure of the composite. Such models will utilize a three dimensional stress analysis due to the complex nature of low velocity impact stresses in thick composites. When these models are coupled with non-contact NDE methods that geometrically characterize the damage and acoustic methods that characterize the effective local elastic properties, accurate assessment of residual strength from impact damage may be possible. Directions for further development are suggested.

Assessment of impact damage of composite rocket motor cases

NASA Astrophysics Data System (ADS)

Paris, Henry G.

1994-02-01

This contract reviewed the available literature on mechanisms of low velocity impact damage in filament wound rocket motor cases, MDE methods to quantify damage, critical coupon level test methods, manufacturing and material process variables and empirical and analytical modeling off impact damage. The critical design properties for rocket motor cases are biaxial hoop and axial tensile strength. Low velocity impact damage is insidious because it can create serious nonvisible damage at very low impact velocities. In thick rocket motor cases the prevalent low velocity impact damage is fiber fracture and matrix cracking adjacent to the front face. In contrast, low velocity loading of thin wall cylinders induces flexure, depending on span length and the flexure induces delamination and tensile cracking on the back face wall opposed to impact occurs due to flexural stresses imposed by impact loading. Important NDE methods for rocket motor cases are non-contacting methods that allow inspection from one side. Among these are vibrothermography, and pulse-echo methods based on acoustic-ultrasonic methods. High resolution techniques such as x-ray computed tomography appear to have merit for accurate geometrical characterization of local damage to support development of analytical models of micromechanics. The challenge of coupon level testing is to reproduce the biaxial stress state that the full scale article experiences, and to determine how to scale the composite structure to model full sized behavior. Biaxial tensile testing has been performed by uniaxially tensile loading internally pressurized cylinders. This is experimentally difficult due to gripping problems and pressure containment. Much prior work focused on uniaxial tensile testing of model filament wound cylinders. Interpretation of the results of some studies is complicated by the fact that the fabrication process did not duplicate full scale manufacturing. It is difficult to scale results from testing subscale cylinders since there are significant differences in out time of the resins relative to full scale cylinder fabrication, differences in hoop fiber tensioning and unsatisfactory coupon configurations. It appears that development of a new test method for subscale cylinders is merited. Damage tolerance may be improved by material optimization that uses fiber treatments and matrix modifications to control the fiber matrix interface bonding. It is difficult to develop process optimization in subscale cylinders without also modeling the longer out times resins experience in full scale testing. A major breakthrough in characterizing the effect of impact damage on residual strength, and understanding how to scale results of subscale evaluations, will be a sound micromechanical model that described progressive failure of the composite.

S100 B: A new concept in neurocritical care

PubMed Central

Rezaei, Omidvar; Pakdaman, Hossein; Gharehgozli, Kurosh; Simani, Leila; Vahedian-Azimi, Amir; Asaadi, Sina; Sahraei, Zahra; Hajiesmaeili, Mohammadreza

2017-01-01

After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neurocritical care domain, an electronic literature search was carried among articles published in English prior to March 2017. They were retrieved from PubMed, Scopus, EMBSCO, CINAHL, ISC and the Cochrane Library using keywords including “brain”, “neurobiochemical marker”, “neurocritical care”, and “S100B protein”. The integrative review included 48 studies until March 2017. S100B protein can be considered as a marker for blood brain barrier damage. The marker has an important role in the development and recovery of normal central nervous system (CNS) after injury. In addition to extra cerebral sources of S100B, the marker is principally built in the astroglial and Schwann cells. The neurobiochemical marker, S100B, has a pathognomonic role in the diagnosis of a broad spectrum of brain damage including traumatic brain injury (TBI), brain tumor, and stroke. Moreover, a potential predicting role for the neurobiochemical marker has been presumed in the efficiency of brain damage treatment and prognosis. However further animal and human studies are required before widespread routine clinical introduction of S100 protein. PMID:28761630

Revision of seismic design codes corresponding to building damages in the ``5.12'' Wenchuan earthquake

NASA Astrophysics Data System (ADS)

Wang, Yayong

2010-06-01

A large number of buildings were seriously damaged or collapsed in the “5.12” Wenchuan earthquake. Based on field surveys and studies of damage to different types of buildings, seismic design codes have been updated. This paper briefly summarizes some of the major revisions that have been incorporated into the “Standard for classification of seismic protection of building constructions GB50223-2008” and “Code for Seismic Design of Buildings GB50011-2001.” The definition of seismic fortification class for buildings has been revisited, and as a result, the seismic classifications for schools, hospitals and other buildings that hold large populations such as evacuation shelters and information centers have been upgraded in the GB50223-2008 Code. The main aspects of the revised GB50011-2001 code include: (a) modification of the seismic intensity specified for the Provinces of Sichuan, Shanxi and Gansu; (b) basic conceptual design for retaining walls and building foundations in mountainous areas; (c) regularity of building configuration; (d) integration of masonry structures and pre-cast RC floors; (e) requirements for calculating and detailing stair shafts; and (f) limiting the use of single-bay RC frame structures. Some significant examples of damage in the epicenter areas are provided as a reference in the discussion on the consequences of collapse, the importance of duplicate structural systems, and the integration of RC and masonry structures.

An update on airborne contact dermatitis.

PubMed

Huygens, S; Goossens, A

2001-01-01

This review is an update of 2 previously published articles on airborne contact dermatoses. Because reports in the literature often omit the term 'airborne', 18 volumes of Contact Dermatitis (April 1991-June 2000), 8 volumes of the American Journal of Contact Dermatitis (1992 1999) and 4 volumes of La Lettre du Gerda (1996-1999) were screened, and the cases cited were classified as to history, lesion locations, sensitization sources, and other factors. Reports on airborne dermatitis are increasingly being published, sometimes in relation to specific occupational areas.

Gossip algorithms in quantum networks

NASA Astrophysics Data System (ADS)

Siomau, Michael

2017-01-01

Gossip algorithms is a common term to describe protocols for unreliable information dissemination in natural networks, which are not optimally designed for efficient communication between network entities. We consider application of gossip algorithms to quantum networks and show that any quantum network can be updated to optimal configuration with local operations and classical communication. This allows to speed-up - in the best case exponentially - the quantum information dissemination. Irrespective of the initial configuration of the quantum network, the update requiters at most polynomial number of local operations and classical communication.

DOE Office of Scientific and Technical Information (OSTI.GOV)

KIRKBRIDE, R.A.

The Tank Waste Remediation System Operation and Utilization Plan updates the operating scenario and plans for the delivery of feed to BNFL Inc., retrieval of waste from single-shell tanks, and the overall process flowsheets for Phases I and II of the privatization of the Tank Waste Remediation System. The plans and flowsheets are updated with the most recent tank-by-tank inventory and sludge washing data. Sensitivity cases were run to evaluate the impact or benefits of proposed changes to the BNFL Inc. contract and to evaluate a risk-based SST retrieval strategy.

Effects of fire damage on the structural properties of steel bridge elements.

DOT National Transportation Integrated Search

2011-04-30

It is well known that fire can cause severe damage to steel bridges. There are documented cases where fire has directly led to the collapse or significant sagging of a steel bridge. However, when the damage is less severe, the effects of the fire, if...

Radiation damage caused by cold neutrons in boron doped CMOS active pixel sensors

NASA Astrophysics Data System (ADS)

Linnik, B.; Bus, T.; Deveaux, M.; Doering, D.; Kudejova, P.; Wagner, F. M.; Yazgili, A.; Stroth, J.

2017-05-01

CMOS Monolithic Active Pixel Sensors (MAPS) are considered as an emerging technology in the field of charged particle tracking. They will be used in the vertex detectors of experiments like STAR, CBM and ALICE and are considered for the ILC and the tracker of ATLAS. In those applications, the sensors are exposed to sizeable radiation doses. While the tolerance of MAPS to ionizing radiation and fast hadrons is well known, the damage caused by low energy neutrons was not studied so far. Those slow neutrons may initiate nuclear fission of 10B dopants found in the B-doped silicon active medium of MAPS. This effect was expected to create an unknown amount of radiation damage beyond the predictions of the NIEL (Non Ionizing Energy Loss) model for pure silicon. We estimate the impact of this effect by calculating the additional NIEL created by this fission. Moreover, we show first measured data for CMOS sensors which were irradiated with cold neutrons. The empirical results contradict the prediction of the updated NIEL model both, qualitatively and quantitatively: the sensors irradiated with slow neutrons show an unexpected and strong acceptor removal, which is not observed in sensors irradiated with MeV neutrons.

Remote sensing for hurricane Andrew impact assessment

NASA Technical Reports Server (NTRS)

Davis, Bruce A.; Schmidt, Nicholas

1994-01-01

Stennis Space Center personnel flew a Learjet equipped with instrumentation designed to acquire imagery in many spectral bands into areas most damaged by Hurricane Andrew. The calibrated airborne multispectral scanner (CAMS), a NASA-developed sensor, and a Zeiss camera acquired images of these areas. The information derived from the imagery was used to assist Florida officials in assessing the devastation caused by the hurricane. The imagery provided the relief teams with an assessment of the debris covering roads and highways so cleanup plans could be prioritized. The imagery also mapped the level of damage in residential and commercial areas of southern Florida and provided maps of beaches and land cover for determination of beach loss and vegetation damage, particularly the mangrove population. Stennis Space Center personnel demonstrated the ability to respond quickly and the value of such response in an emergency situation. The digital imagery from the CAMS can be processed, analyzed, and developed into products for field crews faster than conventional photography. The resulting information is versatile and allows for rapid updating and editing. Stennis Space Center and state officials worked diligently to compile information to complete analyses of the hurricane's impact.

Payments for Improved Ecostructure (PIE): Funding for the Coexistence of Humans and Wolves in Finland.

PubMed

Hiedanpää, Juha; Kalliolevo, Hanna; Salo, Matti; Pellikka, Jani; Luoma, Mikael

2016-09-01

The gray wolf (Canis lupus) is a source of concern and a cause of damage to people's livelihoods. In Finland, as in most countries, actual damages are compensated according to the real lost value. However, often, the suffered damages are larger than what is compensated, and worries and fears are not accounted for at all. The purpose of our transdisciplinary action research is to contribute to the process of modifying the scientific, administrative, and everyday habits of mind in order to meet the practical prerequisites of living with the wolf. In 2014, we planned and participated in a process designed to update Finland's wolf population management plan. During our study, we applied e-deliberation, conducted a national wolf survey, and organized solution-oriented workshops in wolf territory areas around Finland. By applying abductive reasoning, we illustrate the basic features of an economic scheme that would help finance and coordinate practical modifications to the ecological, economic, and institutional circumstances and settings in wolf territory areas. The potential economic instrument is based on payments for improved ecostructures. In our paper, we describe the organization, functioning, and financing of this instrument in detail.

Payments for Improved Ecostructure (PIE): Funding for the Coexistence of Humans and Wolves in Finland

NASA Astrophysics Data System (ADS)

Hiedanpää, Juha; Kalliolevo, Hanna; Salo, Matti; Pellikka, Jani; Luoma, Mikael

2016-09-01

The gray wolf ( Canis lupus) is a source of concern and a cause of damage to people's livelihoods. In Finland, as in most countries, actual damages are compensated according to the real lost value. However, often, the suffered damages are larger than what is compensated, and worries and fears are not accounted for at all. The purpose of our transdisciplinary action research is to contribute to the process of modifying the scientific, administrative, and everyday habits of mind in order to meet the practical prerequisites of living with the wolf. In 2014, we planned and participated in a process designed to update Finland's wolf population management plan. During our study, we applied e-deliberation, conducted a national wolf survey, and organized solution-oriented workshops in wolf territory areas around Finland. By applying abductive reasoning, we illustrate the basic features of an economic scheme that would help finance and coordinate practical modifications to the ecological, economic, and institutional circumstances and settings in wolf territory areas. The potential economic instrument is based on payments for improved ecostructures. In our paper, we describe the organization, functioning, and financing of this instrument in detail.

Methodologies for Adaptive Flight Envelope Estimation and Protection

NASA Technical Reports Server (NTRS)

Tang, Liang; Roemer, Michael; Ge, Jianhua; Crassidis, Agamemnon; Prasad, J. V. R.; Belcastro, Christine

2009-01-01

This paper reports the latest development of several techniques for adaptive flight envelope estimation and protection system for aircraft under damage upset conditions. Through the integration of advanced fault detection algorithms, real-time system identification of the damage/faulted aircraft and flight envelop estimation, real-time decision support can be executed autonomously for improving damage tolerance and flight recoverability. Particularly, a bank of adaptive nonlinear fault detection and isolation estimators were developed for flight control actuator faults; a real-time system identification method was developed for assessing the dynamics and performance limitation of impaired aircraft; online learning neural networks were used to approximate selected aircraft dynamics which were then inverted to estimate command margins. As off-line training of network weights is not required, the method has the advantage of adapting to varying flight conditions and different vehicle configurations. The key benefit of the envelope estimation and protection system is that it allows the aircraft to fly close to its limit boundary by constantly updating the controller command limits during flight. The developed techniques were demonstrated on NASA s Generic Transport Model (GTM) simulation environments with simulated actuator faults. Simulation results and remarks on future work are presented.

Damaging events along roads during bad weather periods: a case study in Calabria (Italy)

NASA Astrophysics Data System (ADS)

Petrucci, O.; Pasqua, A. A.

2012-02-01

The study focuses on circumstances that affect people during periods of bad weather conditions characterised by winds, rainfall, landslides, flooding, and storm surges. A methodological approach and its application to a study area in southern Italy are presented here. A 10-yr database was generated by mining data from a newspaper. Damaging agents were sorted into five types: flood, urban flooding, landslide, wind, and storm surge. Damage to people occurred in 126 cases, causing 13 victims, 129 injured and about 782 people involved but not injured. For cases of floods, urban flooding and landslides, the analysis does not highlight straightforward relationships between rainfall and damage to people, even if the events showed different features according to the months of occurrence. The events occurring between May and October were characterised by concentrated and intense rainfall, and between May and July, the highest values of hourly (103 mm on the average) and monthly rainfall (114 mm on the average) were recorded. Urban flooding and flash floods were the most common damaging agents: injured, involved people and more rarely, cases with victims were reported. Between November and April, the highest number of events was recorded. Rainfall presented longer durations and hourly and sub-hourly rainfall were lower than those recorded between May and October. Landslides were the most frequent damaging agents but the highest number of cases with victims, which occurred between November and January, were mainly related to floods and urban flooding. Motorists represent the totality of the victims; 84% of the people were injured and the whole of people involved. All victims were men, and the average age was 43 yr. The primary cause of death was drowning caused by floods, and the second was trauma suffered in car accidents caused by urban flooding. The high number of motorists rescued in submerged cars reveals an underestimation of danger in the case of floods, often increased by the sense of security related to the familiarity of the road. In contrast, in the cases of people involved in landslides, when there was enough time to realise the potential risk, people behaved appropriately to avoid negative consequences. Of the victims, 50% were killed along fast-flowing roads; this may be related to the high speed limit in force on these roads, as a car's speed reduces the reaction time of a driver's response to an unexpected situation, whatever the damaging agent is. These results can be used in local information/education campaigns to both increase risk awareness and promote self-protective behaviours. Moreover, the mapping of damaging effects pointed out the regional sectors in which the high frequency of the events suggests further planning of in-depth examinations, which can individuate the critical points and local regulator interventions that might change damage incidences in the future.

Ground vibration tests of a high fidelity truss for verification of on orbit damage location techniques

NASA Technical Reports Server (NTRS)

Kashangaki, Thomas A. L.

1992-01-01

This paper describes a series of modal tests that were performed on a cantilevered truss structure. The goal of the tests was to assemble a large database of high quality modal test data for use in verification of proposed methods for on orbit model verification and damage detection in flexible truss structures. A description of the hardware is provided along with details of the experimental setup and procedures for 16 damage cases. Results from selected cases are presented and discussed. Differences between ground vibration testing and on orbit modal testing are also described.

Effects of bolt-hole contact on bearing-bypass damage-onset strength

NASA Technical Reports Server (NTRS)

Crews, John H., Jr.; Naik, Rajiv A.

1991-01-01

A combined experimental and analytical study was conducted to investigate the effects of bolt-hole contact on the bearing bypass strength of a graphite-epoxy laminate. Tests were conducted on specimens consisting of 16-ply quasi-isotropic T300/5208 laminates with a centrally located hole. Bearing loads were applied through a clearance-fit steel bolt. Damage onset strength and damage mode were determined for each test case. A finite element procedure was used to calculate the bolt-hole stresses and bolt contact for each test case. A finite element procedure was used to calculate the bolt-hole stresses and bolt contact for each measured damage-onset strength. For the tension bearing-bypass cases tested, the bolt contact half-angle was approximately 60 degrees at damage onset. For compression, the contact angle was 20 degrees as the bypass load increased. A corresponding decrease in the bearing damage onset strength was attributed to the decrease in contact angle which made the bearing loads more severe. Hole boundary stresses were also computed by superimposing stresses for separate bearing and bypass loading. Stresses at the specimen net section were accurately approximated by the superposition procedure. However, the peak bearing stresses had large errors because the bolt contact angles were not represented correctly. For compression, peak bearing stress errors of nearly 50 percent were calculated.

Hippocampal amnesia.

PubMed

Spiers, H J; Maguire, E A; Burgess, N

2001-01-01

This article reviews 147 cases of amnesia following damage including the hippocampus or fornix as reported in 179 publications. The aetiology, mnestic abilities and reference(s) are tabulated for each case. Consistent findings across cases include the association of bilateral hippocampal damage with a deficit in anterograde episodic memory combined with spared procedural and working memory. The limited nature of retrograde amnesia following lesions to the fornix is also noted. Less consistent and thus more controversial findings, include effects of lesion size or laterality, deficits in semantic memory or familiarity-based recognition and the extent of retrograde amnesia. The evidence concerning these issues is reviewed across cases.

Sex estimation in a modern American osteological sample using a discriminant function analysis from the calcaneus.

PubMed

DiMichele, Daniel L; Spradley, M Katherine

2012-09-10

Reliable methods for sex estimation during the development of a biological profile are important to the forensic community in instances when the common skeletal elements used to assess sex are absent or damaged. Sex estimation from the calcaneus has potentially significant importance for the forensic community. Specifically, measurements of the calcaneus provide an additional reliable method for sex estimation via discriminant function analysis based on a North American forensic population. Research on a modern American sample was chosen in order to develop up-to-date population specific discriminant functions for sex estimation. The current study addresses this matter, building upon previous research and introduces a new measurement, posterior circumference that promises to advance the accuracy of use of this single, highly resistant bone in future instances of sex determination from partial skeletal remains. Data were collected from The William Bass Skeletal Collection, housed at The University of Tennessee. Sample size includes 320 adult individuals born between the years 1900 and 1985. The sample was comprised of 136 females and 184 males. Skeletons used for measurements were confined to those with fused diaphyses showing no signs of pathology or damage that may have altered measurements, and that also had accompanying records that included information on ancestry, age, and sex. Measurements collected and analyzed include maximum length, load-arm length, load-arm width, and posterior circumference. The sample was used to compute a discriminant function, based on all four variables, and was performed in SAS 9.1.3. The discriminant function obtained an overall cross-validated classification rate of 86.69%. Females were classified correctly in 88.64% of the cases and males were correctly classified in 84.75% of the cases. Due to the increasing heterogeneity of current populations further discussion on this topic will include the importance that the re-evaluation of past studies has on modern forensic populations. Due to secular and micro evolutionary changes among populations, the near future must include additional methods being updated, and new methods being examined, both which should cover a wide population spectrum. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

A new methodology for modeling of direct landslide costs for transportation infrastructures

NASA Astrophysics Data System (ADS)

Klose, Martin; Terhorst, Birgit

2014-05-01

The world's transportation infrastructure is at risk of landslides in many areas across the globe. A safe and affordable operation of traffic routes are the two main criteria for transportation planning in landslide-prone areas. The right balancing of these often conflicting priorities requires, amongst others, profound knowledge of the direct costs of landslide damage. These costs include capital investments for landslide repair and mitigation as well as operational expenditures for first response and maintenance works. This contribution presents a new methodology for ex post assessment of direct landslide costs for transportation infrastructures. The methodology includes tools to compile, model, and extrapolate landslide losses on different spatial scales over time. A landslide susceptibility model enables regional cost extrapolation by means of a cost figure obtained from local cost compilation for representative case study areas. On local level, cost survey is closely linked with cost modeling, a toolset for cost estimation based on landslide databases. Cost modeling uses Landslide Disaster Management Process Models (LDMMs) and cost modules to simulate and monetize cost factors for certain types of landslide damage. The landslide susceptibility model provides a regional exposure index and updates the cost figure to a cost index which describes the costs per km of traffic route at risk of landslides. Both indexes enable the regionalization of local landslide losses. The methodology is applied and tested in a cost assessment for highways in the Lower Saxon Uplands, NW Germany, in the period 1980 to 2010. The basis of this research is a regional subset of a landslide database for the Federal Republic of Germany. In the 7,000 km² large Lower Saxon Uplands, 77 km of highway are located in potential landslide hazard area. Annual average costs of 52k per km of highway at risk of landslides are identified as cost index for a local case study area in this region. The cost extrapolation for the Lower Saxon Uplands results in annual average costs for highways of 4.02mn. This test application as well as a validation of selected modeling tools verifies the functionality of this methodology.

Semi Automated Land Cover Layer Updating Process Utilizing Spectral Analysis and GIS Data Fusion

NASA Astrophysics Data System (ADS)

Cohen, L.; Keinan, E.; Yaniv, M.; Tal, Y.; Felus, A.; Regev, R.

2018-04-01

Technological improvements made in recent years of mass data gathering and analyzing, influenced the traditional methods of updating and forming of the national topographic database. It has brought a significant increase in the number of use cases and detailed geo information demands. Processes which its purpose is to alternate traditional data collection methods developed in many National Mapping and Cadaster Agencies. There has been significant progress in semi-automated methodologies aiming to facilitate updating of a topographic national geodatabase. Implementation of those is expected to allow a considerable reduction of updating costs and operation times. Our previous activity has focused on building automatic extraction (Keinan, Zilberstein et al, 2015). Before semiautomatic updating method, it was common that interpreter identification has to be as detailed as possible to hold most reliable database eventually. When using semi-automatic updating methodologies, the ability to insert human insights based knowledge is limited. Therefore, our motivations were to reduce the created gap by allowing end-users to add their data inputs to the basic geometric database. In this article, we will present a simple Land cover database updating method which combines insights extracted from the analyzed image, and a given spatial data of vector layers. The main stages of the advanced practice are multispectral image segmentation and supervised classification together with given vector data geometric fusion while maintaining the principle of low shape editorial work to be done. All coding was done utilizing open source software components.

Dynamic Impact Analyses and Tests of Concrete Overpacks - 13638

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Sanghoon; Cho, Sang-Soon; Kim, Ki-Young

Concrete cask is an option for spent nuclear fuel interim storage which is prevailingly used in US. A concrete cask usually consists of metallic canister which confines the spent nuclear fuel and concrete overpack. When the overpack undergoes a severe missile impact which might be caused by a tornado or an aircraft crash, it should sustain acceptable level of structural integrity so that its radiation shielding capability and the retrievability of canister are maintained. Missile impact against a concrete overpack involves two damage modes, local damage and global damage. Local damage of concrete is usually evaluated by empirical formulas whilemore » the global damage is evaluated by finite element analysis. In many cases, those two damage modes are evaluated separately. In this research, a series of numerical simulations are performed using finite element analysis to evaluate the global damage of concrete overpack as well as its local damage under high speed missile impact. We consider two types of concrete overpack, one with steel in-cased concrete without reinforcement and the other with partially-confined reinforced concrete. The numerical simulation results are compared with test results and it is shown that appropriate modeling of material failure is crucial in this analysis and the results are highly dependent on the choice of failure parameters. (authors)« less

Beyond Re/Presentation: A Case for Updating the Epistemology of Schooling

ERIC Educational Resources Information Center

Biesta, Gert J. J.; Osberg, Deborah

2007-01-01

In this paper we wish to argue that despite strong challenges to representational epistemology in the last two centuries, modern schooling is still organised around a representational view of knowledge. This is the case despite teaching practices being modified to accommodate different views of knowledge that have emerged in the last two…

Pine needle abortion in cattle update: Metabolite detection in sera and fetal fluids from abortion case samples

USDA-ARS?s Scientific Manuscript database

Cattle abortions associated with consumption of pine needles during late gestation are a serious poisonous plant problem in the Western US. Most cases of abortion have been associated with consumption of ponderosa pine (Pinus ponderosa) and the causative agent was identified as the labdane diterpen...

School Officials and the Courts: Update 1985. ERS Monograph.

ERIC Educational Resources Information Center

Beckham, Joseph C.

Cases involving public elementary and secondary education that were decided in state and federal courts from July 1984 to June 1985 are summarized in this review. The cases were selected on the basis of their relevance to contemporary problems in public schools, their definitiveness as articulations of existing law, and their reliability as guides…

Runaways in Juvenile Courts. OJJDP Update on Statistics.

ERIC Educational Resources Information Center

Sickmund, Melissa

The National Center for Juvenile Justice (NCJJ) analyzed records in the Center's National Juvenile Court Data Archive to examine how the juvenile courts handled runaway cases. NCJJ examined 40,000 records of runaway cases processed between 1985 and 1986 in 611 jurisdictions from 12 states representing about one-quarter of the U.S. youth population…

Compendium of animal rabies prevention and control, 2011.

PubMed

2011-11-04

Rabies has one of the highest case-fatality ratios of any infectious disease. This report provides recommendations for public health officials, veterinarians, animal control officials, and other parties engaged in rabies prevention and control activities and should serve as the basis for standardizing procedures among jurisdictions. The recommendations regarding domestic animal vaccination, management of animals exposed to rabies, and management of animals that bite humans are the core elements of animal rabies control and human rabies prevention. These updated 2011 guidelines include the national case definition for animal rabies and clarify the role of the CDC rabies laboratory in providing confirmatory testing of suspect animals. The table of rabies vaccines licensed and marketed in the United States has been updated, and additional references have been included to provide scientific support for information in this report.

75 FR 70371 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

...This final rule sets forth an update to the Home Health Prospective Payment System (HH PPS) rates, including: the national standardized 60-day episode rates, the national per-visit rates, the nonroutine medical supply (NRS) conversion factors, and the low utilization payment amount (LUPA) add-on payment amounts, under the Medicare prospective payment system for HHAs effective January 1, 2011. This rule also updates the wage index used under the HH PPS and, in accordance with the Patient Protection and Affordable Care Act of 2010 (Affordable Care Act), updates the HH PPS outlier policy. In addition, this rule revises the home health agency (HHA) capitalization requirements. This rule further adds clarifying language to the ``skilled services'' section. The rule finalizes a 3.79 percent reduction to rates for CY 2011 to account for changes in case-mix, which are unrelated to real changes in patient acuity. Finally, this rule incorporates new legislative requirements regarding face-to-face encounters with providers related to home health and hospice care.

Optimization of Aerospace Structure Subject to Damage Tolerance Criteria

NASA Technical Reports Server (NTRS)

Akgun, Mehmet A.

1999-01-01

The objective of this cooperative agreement was to seek computationally efficient ways to optimize aerospace structures subject to damage tolerance criteria. Optimization was to involve sizing as well as topology optimization. The work was done in collaboration with Steve Scotti, Chauncey Wu and Joanne Walsh at the NASA Langley Research Center. Computation of constraint sensitivity is normally the most time-consuming step of an optimization procedure. The cooperative work first focused on this issue and implemented the adjoint method of sensitivity computation in an optimization code (runstream) written in Engineering Analysis Language (EAL). The method was implemented both for bar and plate elements including buckling sensitivity for the latter. Lumping of constraints was investigated as a means to reduce the computational cost. Adjoint sensitivity computation was developed and implemented for lumped stress and buckling constraints. Cost of the direct method and the adjoint method was compared for various structures with and without lumping. The results were reported in two papers. It is desirable to optimize topology of an aerospace structure subject to a large number of damage scenarios so that a damage tolerant structure is obtained. Including damage scenarios in the design procedure is critical in order to avoid large mass penalties at later stages. A common method for topology optimization is that of compliance minimization which has not been used for damage tolerant design. In the present work, topology optimization is treated as a conventional problem aiming to minimize the weight subject to stress constraints. Multiple damage configurations (scenarios) are considered. Each configuration has its own structural stiffness matrix and, normally, requires factoring of the matrix and solution of the system of equations. Damage that is expected to be tolerated is local and represents a small change in the stiffness matrix compared to the baseline (undamaged) structure. The exact solution to a slightly modified set of equations can be obtained from the baseline solution economically without actually solving the modified system. Sherrnan-Morrison-Woodbury (SMW) formulas are matrix update formulas that allow this. SMW formulas were therefore used here to compute adjoint displacements for sensitivity computation and structural displacements in damaged configurations.

Flood damage data gathering: procedures and use

NASA Astrophysics Data System (ADS)

Molinari, D.; Aronica, G. T.; Ballio, F.; Berni, N.; Pandolfo, C.

2012-04-01

Damage data represents the basis on which flood risk models, re-founding schemes and mitigation activities are grounded on. Nevertheless damage data have been collected so far mainly at the national-regional scale; few databases exist at the local scale and, even if present, no standard exist for their development. On the contrary, risk analyses and mitigation strategies are usually carried out at local scale. This contribution describes the ongoing activity to collect and analyze local damage data coming from past events with recently hit Umbria an Sicily regions (central and south part of Italy respectively). Data from past events will be discussed from two different perspectives. In Italy, procedures to gather damage data after a flood are defined by law. According to this, authors will first question whether or not collected data are suitable to give an exhaustive representation of the total impact the events had on the affected territories. As regards, suggestions are provided about how gathering procedures can improve. On the other hand, collected data will be discussed with respect to their implementation in the definition of depth-damage curves for the Italian context; literature review highlights indeed that no curves are available for Italy. Starting from the knowledge of observed hazard intensity and damage data, available curves from other countries are validated, the objective being to reduce the uncertainty which currently characterise damage estimation. Indeed, a variety of curves can be found in literature and the choice of one curve in place of another can change damage assessment results of one order of magnitude. The validation procedure will allow, in its turn, to face a secondary but key question for the contribution, being the identification of those hazard and vulnerability features that should be recorded and kept updated in a local GIS database to support risk modelling, funding and management. The two areas under investigation are prone to different types of hazard: flash floods with high debris concentration are typical of the Sicilian area whilst riverine floods are common in the Umbria region. This way, reasoning can be made with respect to different hazard and vulnerability aspects.

Pure word deafness following left temporal damage: Behavioral and neuroanatomical evidence from a new case.

PubMed

Maffei, Chiara; Capasso, Rita; Cazzolli, Giulia; Colosimo, Cesare; Dell'Acqua, Flavio; Piludu, Francesca; Catani, Marco; Miceli, Gabriele

2017-12-01

Pure Word Deafness (PWD) is a rare disorder, characterized by selective loss of speech input processing. Its most common cause is temporal damage to the primary auditory cortex of both hemispheres, but it has been reported also following unilateral lesions. In unilateral cases, PWD has been attributed to the disconnection of Wernicke's area from both right and left primary auditory cortex. Here we report behavioral and neuroimaging evidence from a new case of left unilateral PWD with both cortical and white matter damage due to a relatively small stroke lesion in the left temporal gyrus. Selective impairment in auditory language processing was accompanied by intact processing of nonspeech sounds and normal speech, reading and writing. Performance on dichotic listening was characterized by a reversal of the right-ear advantage typically observed in healthy subjects. Cortical thickness and gyral volume were severely reduced in the left superior temporal gyrus (STG), although abnormalities were not uniformly distributed and residual intact cortical areas were detected, for example in the medial portion of the Heschl's gyrus. Diffusion tractography documented partial damage to the acoustic radiations (AR), callosal temporal connections and intralobar tracts dedicated to single words comprehension. Behavioral and neuroimaging results in this case are difficult to integrate in a pure cortical or disconnection framework, as damage to primary auditory cortex in the left STG was only partial and Wernicke's area was not completely isolated from left or right-hemisphere input. On the basis of our findings we suggest that in this case of PWD, concurrent partial topological (cortical) and disconnection mechanisms have contributed to a selective impairment of speech sounds. The discrepancy between speech and non-speech sounds suggests selective damage to a language-specific left lateralized network involved in phoneme processing. Copyright © 2017 Elsevier Ltd. All rights reserved.

Automated wind load characterization of wind turbine structures by embedded model updating

NASA Astrophysics Data System (ADS)

Swartz, R. Andrew; Zimmerman, Andrew T.; Lynch, Jerome P.

2010-04-01

The continued development of renewable energy resources is for the nation to limit its carbon footprint and to enjoy independence in energy production. Key to that effort are reliable generators of renewable energy sources that are economically competitive with legacy sources. In the area of wind energy, a major contributor to the cost of implementation is large uncertainty regarding the condition of wind turbines in the field due to lack of information about loading, dynamic response, and fatigue life of the structure expended. Under favorable circumstances, this uncertainty leads to overly conservative designs and maintenance schedules. Under unfavorable circumstances, it leads to inadequate maintenance schedules, damage to electrical systems, or even structural failure. Low-cost wireless sensors can provide more certainty for stakeholders by measuring the dynamic response of the structure to loading, estimating the fatigue state of the structure, and extracting loading information from the structural response without the need of an upwind instrumentation tower. This study presents a method for using wireless sensor networks to estimate the spectral properties of a wind turbine tower loading based on its measured response and some rudimentary knowledge of its structure. Structural parameters are estimated via model-updating in the frequency domain to produce an identification of the system. The updated structural model and the measured output spectra are then used to estimate the input spectra. Laboratory results are presented indicating accurate load characterization.

World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management.

PubMed

Gotlib, Jason

2017-11-01

The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary, clonal) disorders with potential for end-organ damage. Hypereosinophilia has generally been defined as a peripheral blood eosinophil count greater than 1500/mm 3 and may be associated with tissue damage. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescent in situ-hybridization, flow immunocytometry, and T-cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid or lymphoproliferative disorder. Disease prognosis relies on identifying the subtype of eosinophilia. After evaluation of secondary causes of eosinophilia, the 2016 World Health Organization endorses a semi-molecular classification scheme of disease subtypes which includes the major category "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2," and the "MPN subtype, chronic eosinophilic leukemia, not otherwise specified" (CEL, NOS). Lymphocyte-variant hypereosinophilia is an aberrant T-cell clone-driven reactive eosinophila, and idiopathic hypereosinophilic syndrome (HES) is a diagnosis of exclusion. The goal of therapy is to mitigate eosinophil-mediated organ damage. For patients with milder forms of eosinophilia (e.g., < 1500/mm 3 ) without symptoms or signs of organ involvement, a watch and wait approach with close-follow-up may be undertaken. Identification of rearranged PDGFRA or PDGFRB is critical because of the exquisite responsiveness of these diseases to imatinib. Corticosteroids are first-line therapy for patients with lymphocyte-variant hypereosinophilia and HES. Hydroxyurea and interferon-alpha have demonstrated efficacy as initial treatment and steroid-refractory cases of HES. In addition to hydroxyurea, second line cytotoxic chemotherapy agents and hematopoietic cell transplant have been used for aggressive forms of HES and CEL with outcomes reported for limited numbers of patients. The use of antibodies against interleukin-5 (IL-5) (mepolizumab), the IL-5 receptor (benralizumab), and CD52 (alemtuzumab), as well as other targets on eosinophils remains an active area of investigation. © 2017 Wiley Periodicals, Inc.

Chromosomal DNA damage measured using the cytokinesis-block micronucleus cytome assay is significantly associated with cognitive impairment in South Australians.

PubMed

Lee, Sau Lai; Thomas, Philip; Hecker, Jane; Faunt, Jeffrey; Fenech, Michael

2015-01-01

Loss of genome integrity may be associated with increased risk for neurodegenerative disease. The aim of this study was to investigate whether mild cognitive impairment (MCI) or Alzheimer's disease (AD) individuals have increased DNA damage relative to age- and gender- matched controls using the cytokinesis-block micronucleus cytome (CBMN-Cyt) assay. DNA damage was measured as micronuclei (MN), nucleoplasmic bridges (NPB), and nuclear buds (NBUD) in binucleated cells. The assay was performed on blood samples from 80 participants consisting of (i) MCI cases (N = 20) and age- and gender- matched controls (N = 20), and (ii) AD cases (N = 20) and age- and gender- matched controls (N = 20). There was a significant increase in MCI NBUD frequency (P = 0.006) relative to controls, which was also observed in male (P = 0.03) and female (P = 0.04) subgroups. For AD cases, there were no significant differences in assay biomarkers relative to controls. There was a significant negative correlation between Mini Mental State Examination (MMSE) and (i) MN in all controls, (R = -0.3, P = 0.04), and AD cases (R = -0.4, P = 0.03), (ii) NPB in all controls, (R = -0.4, P = 0.006) and AD cases (R = -0.5, P = 0.01), and (iii) NBUD in MCI cases (R = -0.5, P = 0.007) and AD cases (R = -0.7, P = 0.0002). The results suggest that an increase in lymphocyte CBMN-Cyt DNA damage biomarkers may be associated with cognitive decline. © 2014 Wiley Periodicals, Inc.

Landsat-7 ETM+ Radiometric Calibration Status

NASA Technical Reports Server (NTRS)

Barsi, Julia A.; Markham, Brian L.; Czapla-Myers, Jeffrey S.; Helder, Dennis L.; Hook, Simon J.; Schott, John R; Haque, Md. Obaidul

2016-01-01

Now in its 17th year of operation, the Enhanced Thematic Mapper + (ETM+), on board the Landsat-7 satellite, continues to systematically acquire imagery of the Earth to add to the 40+ year archive of Landsat data. Characterization of the ETM+ on-orbit radiometric performance has been on-going since its launch in 1999. The radiometric calibration of the reflective bands is still monitored using on-board calibration devices, though the Pseudo-Invariant Calibration Sites (PICS) method has proven to be an effect tool as well. The calibration gains were updated in April 2013 based primarily on PICS results, which corrected for a change of as much as -0.2%/year degradation in the worst case bands. A new comparison with the SADE database of PICS results indicates no additional degradation in the updated calibration. PICS data are still being tracked though the recent trends are not well understood. The thermal band calibration was updated last in October 2013 based on a continued calibration effort by NASA/Jet Propulsion Lab and Rochester Institute of Technology. The update accounted for a 0.31 W/sq m/ sr/micron bias error. The updated lifetime trend is now stable to within + 0.4K.

77 FR 25371 - Transportation of Household Goods in Interstate Commerce; Consumer Protection Regulations...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... services when the shipper agrees to release the carrier from full liability for potential loss and damage... implemented a congressional directive to enhance consumer protection in cases of loss or damage that occur... the estimates they provide to prospective shippers: WARNING: If a moving company loses or damages your...

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Assessment of Liquidated Damages § 133.51 Relief from forfeiture or liquidated damages. (a) Petition for... of § 133.24 or § 133.46. (b) Conditioned relief. In appropriate cases, except for articles bearing a... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1...

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Assessment of Liquidated Damages § 133.51 Relief from forfeiture or liquidated damages. (a) Petition for... of § 133.24 or § 133.46. (b) Conditioned relief. In appropriate cases, except for articles bearing a... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1...

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Assessment of Liquidated Damages § 133.51 Relief from forfeiture or liquidated damages. (a) Petition for... of § 133.24 or § 133.46. (b) Conditioned relief. In appropriate cases, except for articles bearing a... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1...

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Assessment of Liquidated Damages § 133.51 Relief from forfeiture or liquidated damages. (a) Petition for... of § 133.24 or § 133.46. (b) Conditioned relief. In appropriate cases, except for articles bearing a... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1...

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Assessment of Liquidated Damages § 133.51 Relief from forfeiture or liquidated damages. (a) Petition for... of § 133.24 or § 133.46. (b) Conditioned relief. In appropriate cases, except for articles bearing a... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1...

A sneaky surgical emergency: Acute compartment syndrome. Retrospective analysis of 66 closed claims, medico-legal pitfalls and damages evaluation.

PubMed

Marchesi, M; Marchesi, A; Calori, G M; Cireni, L V; Sileo, G; Merzagora, I; Zoia, R; Vaienti, L; Morini, O

2014-12-01

Acute compartment syndrome (ACS) is a clinical condition with potentially dramatic consequences, therefore, it is important to recognise and treat it early. Good management of ACS minimises or avoids the sequelae associated with a late diagnosis, and may also reduce the risk of malpractice claims. The aim of this article was to evaluate different errors ascribed to the surgeon and to identify how the damage was evaluated. A total of 66 completed and closed ACS cases were selected. The following were analysed for each case: clinical management before and after diagnosis of ACS, imputed errors, professional fault, damage evaluation and quantification. Particular attention was paid to distinguishing between impairment because of primary injury and iatrogenic impairment. Statistical analyses were performed using Fisher's exact test and Pearson's correlation. The most common presenting symptom was pain. Delay in the diagnosis, and hence delay in decompression, was common in the study. A total of 48 out of 66 cases resolved with the verdict of iatrogenic damage, which varied from 12% to 75% of global capability of the person. A total of $394,780 out of $574,680 (average payment) derived from a medical error. ACS is a clinical emergency that requires continuous clinical surveillance from both medical and nursing staff. The related damage should be evaluated in two parts: damage deriving from the trauma, so that it is considered inevitable and independent from the surgeon's conduct, and damage deriving from a surgeon's error, which is eligible for an indemnity payment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Dissemination of health information through social networks: twitter and antibiotics.

PubMed

Scanfeld, Daniel; Scanfeld, Vanessa; Larson, Elaine L

2010-04-01

This study reviewed Twitter status updates mentioning "antibiotic(s)" to determine overarching categories and explore evidence of misunderstanding or misuse of antibiotics. One thousand Twitter status updates mentioning antibiotic(s) were randomly selected for content analysis and categorization. To explore cases of potential misunderstanding or misuse, these status updates were mined for co-occurrence of the following terms: "cold + antibiotic(s)," "extra + antibiotic(s)," "flu + antibiotic(s)," "leftover + antibiotic(s)," and "share + antibiotic(s)" and reviewed to confirm evidence of misuse or misunderstanding. Of the 1000 status updates, 971 were categorized into 11 groups: general use (n = 289), advice/information (n = 157), side effects/negative reactions (n = 113), diagnosis (n = 102), resistance (n = 92), misunderstanding and/or misuse (n = 55), positive reactions (n = 48), animals (n = 46), other (n = 42), wanting/needing (n = 19), and cost (n = 8). Cases of misunderstanding or abuse were identified for the following combinations: "flu + antibiotic(s)" (n = 345), "cold + antibiotic(s)" (n = 302), "leftover + antibiotic(s)" (n = 23), "share + antibiotic(s)" (n = 10), and "extra + antibiotic(s)" (n = 7). Social media sites offer means of health information sharing. Further study is warranted to explore how such networks may provide a venue to identify misuse or misunderstanding of antibiotics, promote positive behavior change, disseminate valid information, and explore how such tools can be used to gather real-time health data. 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

Nonexpansiveness of a linearized augmented Lagrangian operator for hierarchical convex optimization

NASA Astrophysics Data System (ADS)

Yamagishi, Masao; Yamada, Isao

2017-04-01

Hierarchical convex optimization concerns two-stage optimization problems: the first stage problem is a convex optimization; the second stage problem is the minimization of a convex function over the solution set of the first stage problem. For the hierarchical convex optimization, the hybrid steepest descent method (HSDM) can be applied, where the solution set of the first stage problem must be expressed as the fixed point set of a certain nonexpansive operator. In this paper, we propose a nonexpansive operator that yields a computationally efficient update when it is plugged into the HSDM. The proposed operator is inspired by the update of the linearized augmented Lagrangian method. It is applicable to characterize the solution set of recent sophisticated convex optimization problems found in the context of inverse problems, where the sum of multiple proximable convex functions involving linear operators must be minimized to incorporate preferable properties into the minimizers. For such a problem formulation, there has not yet been reported any nonexpansive operator that yields an update free from the inversions of linear operators in cases where it is utilized in the HSDM. Unlike previously known nonexpansive operators, the proposed operator yields an inversion-free update in such cases. As an application of the proposed operator plugged into the HSDM, we also present, in the context of the so-called superiorization, an algorithmic solution to a convex optimization problem over the generalized convex feasible set where the intersection of the hard constraints is not necessarily simple.

Outrunning damage: Electrons vs X-rays-timescales and mechanisms.

PubMed

Spence, John C H

2017-07-01

Toward the end of his career, Zewail developed strong interest in fast electron spectroscopy and imaging, a field to which he made important contributions toward his aim of making molecular movies free of radiation damage. We therefore compare here the atomistic mechanisms leading to destruction of protein samples in diffract-and-destroy experiments for the cases of high-energy electron beam irradiation and X-ray laser pulses. The damage processes and their time-scales are compared and relevant elastic, inelastic, and photoelectron cross sections are given. Inelastic mean-free paths for ejected electrons at very low energies in insulators are compared with the bioparticle size. The dose rate and structural damage rate for electrons are found to be much lower, allowing longer pulses, reduced beam current, and Coulomb interactions for the formation of smaller probes. High-angle electron scattering from the nucleus, which has no parallel in the X-ray case, tracks the slowly moving nuclei during the explosion, just as the gain of the XFEL (X-ray free-electron laser) has no parallel in the electron case. Despite reduced damage and much larger elastic scattering cross sections in the electron case, leading to not dissimilar elastic scattering rates (when account is taken of the greatly increased incident XFEL fluence), progress for single-particle electron diffraction is seen to depend on the effort to reduce emittance growth due to Coulomb interactions, and so allow formation of intense sub-micron beams no larger than a virus.

DNA Damage Analysis in Children with Non-syndromic Developmental Delay by Comet Assay.

PubMed

Susai, Surraj; Chand, Parkash; Ballambattu, Vishnu Bhat; Hanumanthappa, Nandeesha; Veeramani, Raveendranath

2016-05-01

Majority of the developmental delays in children are non-syndromic and they are believed to have an underlying DNA damage, though not well substantiated. Hence the present study was carried out to find out if there is any increased DNA damage in children with non-syndromic developmental delay by using the comet assay. The present case-control study was undertaken to assess the level of DNA damage in children with non syndromic developmental delay and compare the same with that of age and sex matched controls using submarine gel electrophoresis (Comet Assay). The blood from clinically diagnosed children with non syndromic developmental delay and controls were subjected for alkaline version of comet assay - Single cell gel electrophoresis using lymphocytes isolated from the peripheral blood. The comets were observed under a bright field microscope; photocaptured and scored using the Image J image quantification software. Comet parameters were compared between the cases and controls and statistical analysis and interpretation of results was done using the statistical software SPSS version 20. The mean comet tail length in cases and control was 20.77+7.659μm and 08.97+4.398μm respectively which was statistically significant (p<0.001). Other comet parameters like total comet length and % DNA in tail also showed a statistically significant difference (p < 0.001) between cases and controls. The current investigation unraveled increased levels of DNA damage in children with non syndromic developmental delay when compared to the controls.

Outrunning damage: Electrons vs X-rays—timescales and mechanisms

PubMed Central

Spence, John C. H.

2017-01-01

Toward the end of his career, Zewail developed strong interest in fast electron spectroscopy and imaging, a field to which he made important contributions toward his aim of making molecular movies free of radiation damage. We therefore compare here the atomistic mechanisms leading to destruction of protein samples in diffract-and-destroy experiments for the cases of high-energy electron beam irradiation and X-ray laser pulses. The damage processes and their time-scales are compared and relevant elastic, inelastic, and photoelectron cross sections are given. Inelastic mean-free paths for ejected electrons at very low energies in insulators are compared with the bioparticle size. The dose rate and structural damage rate for electrons are found to be much lower, allowing longer pulses, reduced beam current, and Coulomb interactions for the formation of smaller probes. High-angle electron scattering from the nucleus, which has no parallel in the X-ray case, tracks the slowly moving nuclei during the explosion, just as the gain of the XFEL (X-ray free-electron laser) has no parallel in the electron case. Despite reduced damage and much larger elastic scattering cross sections in the electron case, leading to not dissimilar elastic scattering rates (when account is taken of the greatly increased incident XFEL fluence), progress for single-particle electron diffraction is seen to depend on the effort to reduce emittance growth due to Coulomb interactions, and so allow formation of intense sub-micron beams no larger than a virus. PMID:28653018

A comparative survey of the impacts of extreme rainfall in two international case studies

NASA Astrophysics Data System (ADS)

Spekkers, Matthieu; Rözer, Viktor; Thieken, Annegret; ten Veldhuis, Marie-Claire; Kreibich, Heidi

2017-08-01

Flooding is assessed as the most important natural hazard in Europe, causing thousands of deaths, affecting millions of people and accounting for large economic losses in the past decade. Little is known about the damage processes associated with extreme rainfall in cities, due to a lack of accurate, comparable and consistent damage data. The objective of this study is to investigate the impacts of extreme rainfall on residential buildings and how affected households coped with these impacts in terms of precautionary and emergency actions. Analyses are based on a unique dataset of damage characteristics and a wide range of potential damage explaining variables at the household level, collected through computer-aided telephone interviews (CATI) and an online survey. Exploratory data analyses based on a total of 859 completed questionnaires in the cities of Münster (Germany) and Amsterdam (the Netherlands) revealed that the uptake of emergency measures is related to characteristics of the hazardous event. In case of high water levels, more efforts are made to reduce damage, while emergency response that aims to prevent damage is less likely to be effective. The difference in magnitude of the events in Münster and Amsterdam, in terms of rainfall intensity and water depth, is probably also the most important cause for the differences between the cities in terms of the suffered financial losses. Factors that significantly contributed to damage in at least one of the case studies are water contamination, the presence of a basement in the building and people's awareness of the upcoming event. Moreover, this study confirms conclusions by previous studies that people's experience with damaging events positively correlates with precautionary behaviour. For improving future damage data acquisition, we recommend the inclusion of cell phones in a CATI survey to avoid biased sampling towards certain age groups.

Research study on high energy radiation effect and environment solar cell degradation methods

NASA Technical Reports Server (NTRS)

Horne, W. E.; Wilkinson, M. C.

1974-01-01

The most detailed and comprehensively verified analytical model was used to evaluate the effects of simplifying assumptions on the accuracy of predictions made by the external damage coefficient method. It was found that the most serious discrepancies were present in heavily damaged cells, particularly proton damaged cells, in which a gradient in damage across the cell existed. In general, it was found that the current damage coefficient method tends to underestimate damage at high fluences. An exception to this rule was thick cover-slipped cells experiencing heavy degradation due to omnidirectional electrons. In such cases, the damage coefficient method overestimates the damage. Comparisons of degradation predictions made by the two methods and measured flight data confirmed the above findings.

Pharyngitis - sore throat

MedlinePlus

... by colds, the flu, coxsackie virus or mono (mononucleosis). Bacteria that can cause pharyngitis in some cases: ... Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition. 8th ed. Philadelphia, PA: Elsevier ...

Impact of ASTM Standard E722 update on radiation damage metrics

DOE Office of Scientific and Technical Information (OSTI.GOV)

DePriest, Kendall Russell

2014-06-01

The impact of recent changes to the ASTM Standard E722 is investigated. The methodological changes in the production of the displacement kerma factors for silicon has significant impact for some energy regions of the 1-MeV(Si) equivalent fluence response function. When evaluating the integral over all neutrons energies in various spectra important to the SNL electronics testing community, the change in the response results in an increase in the total 1-MeV(Si) equivalent fluence of 2 7%. Response functions have been produced and are available for users of both the NuGET and MCNP codes.

An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - 1989

DTIC Science & Technology

1989-04-17

Perforation 0 1 1 533.4 Peptic Ulcer with Haemorrhage 0 0 1 540-543 Appendici ti s 540.0 Acute Apyendicitis, Peritonitis 0 0 1 560-569 Intestine and...Hand C1-C5 Comp 530-537 Oesophagus, Stomach and Duodenum 531.9 Gastric Ulcer 0 0 1 532.4 Duodenal Ulcer with Haemorrhage 0 0 1 532.5 Duodenal Ulcer with...Stomach and-Duodenum 532.4 Duodenal Ulcer with Haemorrhage 0 0 1 570-579 Digestive System, Other 571.3 Alcoholic Liver Damage, Unspecified 0 0 1 Total 0 0 2

[GESIDA/National AIDS Plan: Consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (Updated January 2015)].

PubMed

2015-10-01

This consensus document is an update of combined antiretroviral therapy (cART) guidelines and recommendations for HIV-1 infected adult patients. To formulate these recommendations, a panel composed of members of the AIDS Study Group and the AIDS National Plan (GeSIDA/Plan Nacional sobre el Sida) reviewed the efficacy and safety advances in clinical trials, and cohort and pharmacokinetic studies published in medical journals (PubMed and Embase) or presented in medical scientific meetings. The strength of the recommendations, and the evidence that supports them, are based on modified criteria of the Infectious Diseases Society of America. In this update, cART is recommended for all patients infected by type 1 human immunodeficiency virus (HIV-1). The strength and level of the recommendation depends on the CD4+T-lymphocyte count, the presence of opportunistic diseases or comorbid conditions, age, and prevention of transmission of HIV. The objective of cART is to achieve an undetectable plasma viral load. Initial cART should always comprise a combination of 3 drugs, including 2 nucleoside reverse transcriptase inhibitors, and a third drug from a different family. Three out of the ten recommended regimes are regarded as preferential (all of them with an integrase inhibitor as the third drug), and the other seven (based on a non-nucleoside reverse transcriptase inhibitor, a ritonavir-boosted protease inhibitor, or an integrase inhibitor) as alternatives. This update presents the causes and criteria for switching cART in patients with undetectable plasma viral load, and in cases of virological failure where rescue cART should comprise 3 (or at least 2) drugs that are fully active against the virus. An update is also provided for the specific criteria for cART in special situations (acute infection, HIV-2 infection, and pregnancy) and with comorbid conditions (tuberculosis or other opportunistic infections, kidney disease, liver disease, and cancer). These new guidelines update previous recommendations related to cART (when to begin and what drugs should be used), how to monitor and what to do in case of viral failure or drug adverse reactions. cART specific criteria in comorbid patients and special situations are equally updated. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Design and analysis of compound flexible skin based on deformable honeycomb

NASA Astrophysics Data System (ADS)

Zou, Tingting; Zhou, Li

2017-04-01

In this study, we focused at the development and verification of a robust framework for surface crack detection in steel pipes using measured vibration responses; with the presence of multiple progressive damage occurring in different locations within the structure. Feature selection, dimensionality reduction, and multi-class support vector machine were established for this purpose. Nine damage cases, at different locations, orientations and length, were introduced into the pipe structure. The pipe was impacted 300 times using an impact hammer, after each damage case, the vibration data were collected using 3 PZT wafers which were installed on the outer surface of the pipe. At first, damage sensitive features were extracted using the frequency response function approach followed by recursive feature elimination for dimensionality reduction. Then, a multi-class support vector machine learning algorithm was employed to train the data and generate a statistical model. Once the model is established, decision values and distances from the hyper-plane were generated for the new collected data using the trained model. This process was repeated on the data collected from each sensor. Overall, using a single sensor for training and testing led to a very high accuracy reaching 98% in the assessment of the 9 damage cases used in this study.

Detection of surface cracking in steel pipes based on vibration data using a multi-class support vector machine classifier

NASA Astrophysics Data System (ADS)

Mustapha, S.; Braytee, A.; Ye, L.

2017-04-01

In this study, we focused at the development and verification of a robust framework for surface crack detection in steel pipes using measured vibration responses; with the presence of multiple progressive damage occurring in different locations within the structure. Feature selection, dimensionality reduction, and multi-class support vector machine were established for this purpose. Nine damage cases, at different locations, orientations and length, were introduced into the pipe structure. The pipe was impacted 300 times using an impact hammer, after each damage case, the vibration data were collected using 3 PZT wafers which were installed on the outer surface of the pipe. At first, damage sensitive features were extracted using the frequency response function approach followed by recursive feature elimination for dimensionality reduction. Then, a multi-class support vector machine learning algorithm was employed to train the data and generate a statistical model. Once the model is established, decision values and distances from the hyper-plane were generated for the new collected data using the trained model. This process was repeated on the data collected from each sensor. Overall, using a single sensor for training and testing led to a very high accuracy reaching 98% in the assessment of the 9 damage cases used in this study.

Judo as a possible cause of anoxic brain damage. A case report.

PubMed

Owens, R G; Ghadiali, E J

1991-12-01

The rules of judo provide for strangulation techniques in which the blood supply to the brain is blocked by pressure on the carotid arteries; such techniques produce anoxia and possible unconsciousness if the victim fails to submit. A case is presented of a patient with signs of anoxic brain damage, with psychometric investigation showing memory disturbance consistent with a left temporal lobe lesion. This patient had been frequently strangled during his career as a judo player; it is suggested that such frequent strangulation was the cause of the damage. Such an observation indicates the need for caution in the use of such techniques.

Florivory and nectar-robbing perforations in flowers of pointleaf manzanita Arctostaphylos pungens (Ericaceae) and their effects on plant reproductive success

PubMed Central

Eliyahu, Dorit; McCall, Andrew C.; Lauck, Marina; Trakhtenbrot, Ana

2015-01-01

Damage to petals may have varying effects on the reproductive success of the plant. The variation may depend on the kind of damage to the corolla. Whether the damage is limited to the corolla, as is usually the case with nectar-robbing perforations, or extending to the reproductive parts of the flower, as in the case of florivory holes, might determine the extent of the effect on the plant's reproduction. We examined the various perforations in the flowers of Arctostaphylos pungens and correlated their presence with fruiting success. We found that though florivory holes were highly associated with damage to reproductive parts, fruiting success did not differ significantly between flowers with the two kinds of damage. Although nectar-robbing perforations were not associated with reduced number of fruit produced, they were significantly correlated with reduced number of fruit that contained seemingly viable seeds. The implications of our findings are discussed in the context of pollination and antagonism. PMID:26811740

Florivory and nectar-robbing perforations in flowers of pointleaf manzanita Arctostaphylos pungens (Ericaceae) and their effects on plant reproductive success.

PubMed

Eliyahu, Dorit; McCall, Andrew C; Lauck, Marina; Trakhtenbrot, Ana

2015-12-01

Damage to petals may have varying effects on the reproductive success of the plant. The variation may depend on the kind of damage to the corolla. Whether the damage is limited to the corolla, as is usually the case with nectar-robbing perforations, or extending to the reproductive parts of the flower, as in the case of florivory holes, might determine the extent of the effect on the plant's reproduction. We examined the various perforations in the flowers of Arctostaphylos pungens and correlated their presence with fruiting success. We found that though florivory holes were highly associated with damage to reproductive parts, fruiting success did not differ significantly between flowers with the two kinds of damage. Although nectar-robbing perforations were not associated with reduced number of fruit produced, they were significantly correlated with reduced number of fruit that contained seemingly viable seeds. The implications of our findings are discussed in the context of pollination and antagonism.

[Pitfalls in informed consent: a statistical analysis of malpractice law suits].

PubMed

Echigo, Junko

2014-05-01

In medical malpractice law suits, the notion of informed consent is often relevant in assessing whether negligence can be attributed to the medical practitioner who has caused injury to a patient. Furthermore, it is not rare that courts award damages for a lack of appropriate informed consent alone. In this study, two results were arrived at from a statistical analysis of medical malpractice law suits. One, unexpectedly, was that the severity of a patient's illness made no significant difference to whether damages were awarded. The other was that cases of typical medical treatment that national medical insurance does not cover were involved significantly more often than insured treatment cases. In cases where damages were awarded, the courts required more disclosure and written documents of information by medical practitioners, especially about complications and adverse effects that the patient might suffer.

Antibiotics for acute pyelonephritis in children.

PubMed

Strohmeier, Yvonne; Hodson, Elisabeth M; Willis, Narelle S; Webster, Angela C; Craig, Jonathan C

2014-07-28

Urinary tract infection (UTI) is one of the most common bacterial infections in infants. The most severe form of UTI is acute pyelonephritis, which results in significant acute morbidity and may cause permanent kidney damage. There remains uncertainty regarding the optimum antibiotic regimen, route of administration and duration of treatment. This is an update of a review that was first published in 2003 and updated in 2005 and 2007. To evaluate the benefits and harms of antibiotics used to treat children with acute pyelonephritis. The aspects of therapy considered were 1) different antibiotics, 2) different dosing regimens of the same antibiotic, 3) different duration of treatment, and 4) different routes of administration. We searched the Cochrane Renal Group's Specialised Register, CENTRAL, MEDLINE, EMBASE, reference lists of articles and conference proceedings without language restriction to 10 April 2014. Randomised and quasi-randomised controlled trials comparing different antibiotic agents, routes, frequencies or durations of therapy in children aged 0 to 18 years with proven UTI and acute pyelonephritis were selected. Four authors independently assessed study quality and extracted data. Statistical analyses were performed using the random-effects model and the results expressed as risk ratio (RR) for dichotomous outcomes or mean difference (MD) for continuous data with 95% confidence intervals (CI). This updated review included 27 studies (4452 children). This update included evidence from three new studies, and following re-evaluation, a previously excluded study was included because it now met our inclusion criteria.Risk of bias was assessed as low for sequence generation (12 studies), allocation concealment (six studies), blinding of outcome assessors (17 studies), incomplete outcome reporting (19 studies) and selective outcome reporting (13 studies). No study was blinded for participants or investigators. The 27 included studies evaluated 12 different comparisons. No significant differences were found in duration of fever (2 studies, 808 children: MD 2.05 hours, 95% CI -0.84 to 4.94), persistent UTI at 72 hours after commencing therapy (2 studies, 542 children: RR 1.10, 95% CI 0.07 to 17.41) or persistent kidney damage at six to 12 months (4 studies, 943 children: RR 0.82, 95% CI 0.59 to 1.12) between oral antibiotic therapy (10 to 14 days) and intravenous (IV) therapy (3 days) followed by oral therapy (10 days). Similarly, no significant differences in persistent bacteriuria at the end of treatment (4 studies, 305 children: RR 0.78, 95% CI 0.24 to 2.55) or persistent kidney damage (4 studies, 726 children: RR 1.01, 95% CI 0.80 to 1.29) were found between IV therapy (three to four days) followed by oral therapy and IV therapy (seven to 14 days). No significant differences in efficacy were found between daily and thrice daily administration of aminoglycosides (1 study, 179 children, persistent clinical symptoms at three days: RR 1.98, 95% CI 0.37 to 10.53). Adverse events were mild and uncommon and rarely resulted in discontinuation of treatment. This updated review increases the body of evidence that oral antibiotics alone are as effective as a short course (three to four days) of IV antibiotics followed by oral therapy for a total treatment duration of 10 to 14 days for the treatment of acute pyelonephritis in children. When IV antibiotics are given, a short course (two to four days) of IV therapy followed by oral therapy is as effective as a longer course (seven to 10 days) of IV therapy. If IV therapy with aminoglycosides is chosen, single daily dosing is safe and effective. Insufficient data are available to extrapolate these findings to children aged less than one month of age or to children with dilating vesicoureteric reflux (grades III-V). Further studies are required to determine the optimal total duration of antibiotic therapy required for acute pyelonephritis.

Lesions along the upper motor neuronal pathway with locked-in features after lightning strike and cardiac arrest: a case-review analysis.

PubMed

Abdulla, Susanne; Conrad, Anton; Schwemm, Karl-Peter; Stienstra, Mark P; Gorsselink, Edward L; Dengler, Reinhard; Abdulla, Walied

2014-01-01

This study describes a case of lesions of the upper motor neuronal pathway with locked-in features after lightning strike and cardiac arrest. A case-review analysis. In a 29-year-old male who was hit by a lightning strike during farming activities, cardiopulmonary resuscitation was provided first by co-workers and continued with success by the medical rescue service. After conducting advanced life support under monitoring and therapeutic hypothermia, quadriplegia with facial diplegia was recognized. A review was undertaken detailing the clinical course. MR imaging presented signs consistent with hypoxia-induced damage and diffusion-weighted MR images revealed pronounced damages along the upper motor neuronal pathway. A reactive electroencephalogram pattern, sustained eye movement and the patient communicating via eye-blinking were interpreted as locked-in features. Two weeks after admission the patient was transferred to a neurological rehabilitation centre for further professional care. Direct damage of the upper motor neuron pathway due to the current of the lightning should be considered, albeit the relative contribution of hypoxia-induced damage cannot be separated.

Developmental outcomes after early prefrontal cortex damage.

PubMed

Eslinger, Paul J; Flaherty-Craig, Claire V; Benton, Arthur L

2004-06-01

The neuropsychological bases of cognitive, social, and moral development are minimally understood, with a seemingly wide chasm between developmental theories and brain maturation models. As one approach to bridging ideas in these areas, we review 10 cases of early prefrontal cortex damage from the clinical literature, highlighting overall clinical profiles and real life developmental outcomes. Based on these cases, there is preliminary evidence to support distinctive developmental differences after: (1) dorsolateral, (2) mesial, and (3) orbital-polar prefrontal lesions, for more profound impairments after bilateral damage, and possibly for recovery differences after very early vs. later childhood lesion onset. Further case and group studies are needed to confirm reliable effects of specific lesion locations, the influence of age of lesion onset, and related experiential and treatment variables in determining adult outcomes. Rather than a single underlying deficit associated with early prefrontal cortex damage, we interpret the findings to suggest that it is the altered integration and interplay of cognitive, emotional, self-regulatory, and executive/metacognitive deficits that contribute to diverse developmental frontal lobe syndromes. The findings support the fundamental importance of prefrontal cortex maturation in protracted cognitive, social-emotional, and moral development.

Cost-effective and rapid concrete repair techniques.

DOT National Transportation Integrated Search

2016-02-08

Concrete is a principal component of many transportation structures. While highly durable, a : variety of processes degrade and damage concrete. Replacement is expensive. Many cases : warrant repair instead of replacement. Since many damage processes...

A study of pump cavitation damage

NASA Astrophysics Data System (ADS)

Brophy, M. C.; Stinebring, D. R.; Billet, M. L.

1983-11-01

The cavitation assessment for the space shuttle main engine high pressure oxidizer turbopump is documented. A model of the flow through the pump was developed. Initially, a computational procedure was used to analyze the flow through the inlet casing including the prediction of wakes downstream of the casing vanes. From these flow calculations, cavitation patterns on the inducer blades were approximated and the damage rate estimated. The model correlates the heavy damage on the housing and over the inducer with unsteady blade surface cavitation. The unsteady blade surface cavitation is due to the large incidence changes caused by the wakes of the upstream vanes. Very high cavitation damage rates are associated with this type of cavitation. Design recommendations for reducing the unsteady cavitation include removing the set of vanes closest to the inducer and modifying the remaining vanes.

Possible mechanisms for delayed neurological damage in lightning and electrical injury.

PubMed

Reisner, Andrew D

2013-01-01

This article provides and reviews hypotheses to help explain the poorly understood phenomenon of delayed neurological injury following lightning or electrical injury. A review of extant literature provides a starting point to integrate what is already known in an attempt to provide new hypotheses for this phenomenon, as well as to discuss existing hypotheses. The author proposes two theories which stem from the literature on the damaging effects of oxidative stress, and also reviews an existing hypothesis, the electroporation hypothesis. The former two theories can account for delayed damage which is either of vascular or nonvascular origin. The electroporation hypothesis can explain changes both in cases where there is cellular loss as well as cases where there only appears to be change in function after lightning or electrical injury. Although all theories discussed are speculative, the formation of hypotheses is always a starting point in the scientific process. In cases where there is delayed neurological damage with a vascular origin, it is possible that free radicals resulting from oxidative stress may gradually damage spinal vascular endothelial cells, cutting off blood supply, and ending in death of spinal neurons. When the delayed condition is demyelination without vascular damage, it is possible that the free radicals from oxidative stress are formed directly from the lipids found in abundance in myelin cells. The electroporation hypothesis, the formation of additional pores in neurons, may best explain immediate or progressive changes in structure and function after lightning or electrical injury.

Delamination Assessment Tool for Spacecraft Composite Structures

NASA Astrophysics Data System (ADS)

Portela, Pedro; Preller, Fabian; Wittke, Henrik; Sinnema, Gerben; Camanho, Pedro; Turon, Albert

2012-07-01

Fortunately only few cases are known where failure of spacecraft structures due to undetected damage has resulted in a loss of spacecraft and launcher mission. However, several problems related to damage tolerance and in particular delamination of composite materials have been encountered during structure development of various ESA projects and qualification testing. To avoid such costly failures during development, launch or service of spacecraft, launcher and reusable launch vehicles structures a comprehensive damage tolerance verification approach is needed. In 2009, the European Space Agency (ESA) initiated an activity called “Delamination Assessment Tool” which is led by the Portuguese company HPS Lda and includes academic and industrial partners. The goal of this study is the development of a comprehensive damage tolerance verification approach for launcher and reusable launch vehicles (RLV) structures, addressing analytical and numerical methodologies, material-, subcomponent- and component testing, as well as non-destructive inspection. The study includes a comprehensive review of current industrial damage tolerance practice resulting from ECSS and NASA standards, the development of new Best Practice Guidelines for analysis, test and inspection methods and the validation of these with a real industrial case study. The paper describes the main findings of this activity so far and presents a first iteration of a Damage Tolerance Verification Approach, which includes the introduction of novel analytical and numerical tools at an industrial level. This new approach is being put to the test using real industrial case studies provided by the industrial partners, MT Aerospace, RUAG Space and INVENT GmbH

Update on State-Wide School Finance Cases. School Finance Project.

ERIC Educational Resources Information Center

Lawyers' Committee for Civil Rights Under Law, Washington, DC.

In May 1974, the School Finance Project of the Lawyers' Committee published a Summary of State-Wide School Finance Cases. Its purpose was to provide an overview of the field so that interested persons could quickly learn the status of school finance litigation in the several states. This was accomplished by tracing the procedural history of each…

75 FR 42835 - Medicare Program; Inpatient Rehabilitation Facility Prospective Payment System for Federal Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... estimated cost of the case exceeds the adjusted outlier threshold. We calculate the adjusted outlier... to 80 percent of the difference between the estimated cost of the case and the outlier threshold. In... Federal Prospective Payment Rates VI. Update to Payments for High-Cost Outliers under the IRF PPS A...

An Update of Judicial Rulings Specific to FBAs or BIPs under the IDEA and Corollary State Laws

ERIC Educational Resources Information Center

Zirkel, Perry A.

2017-01-01

Exemplifying the insufficient treatment of legal issues in refereed journals in special education and related fields, the limited legal coverage of functional behavioral assessments (FBAs) and behavior intervention plans (BIPs) tends to view the applicable case law through normative lenses. This skewed view characterizes the case law as requiring…

Considering Generality in the Systematic Review and Meta-Analysis of Single-Case Research: A Response to Hitchcock et al.

ERIC Educational Resources Information Center

Maggin, Daniel M.

2015-01-01

This paper responds to the commentary provided by Hitchcock et al. "(Journal of Behavioral Education," 2015) which provides updated information on the procedures for considering the generality of an intervention using the "What Works Clearinghouse" (WWC) single-case guidelines. The new information provided by Hitchcock et al.…

MOVES sensitivity analysis update : Transportation Research Board Summer Meeting 2012 : ADC-20 Air Quality Committee

DOT National Transportation Integrated Search

2012-01-01

OVERVIEW OF PRESENTATION : Evaluation Parameters : EPAs Sensitivity Analysis : Comparison to Baseline Case : MOVES Sensitivity Run Specification : MOVES Sensitivity Input Parameters : Results : Uses of Study

CDC's Cervical Cancer Study

MedlinePlus

... Radon What We Know What States Can Do Case Study: Reducing Radon in Illinois What Comprehensive Cancer Control ... reviewed: July 9, 2015 Page last updated: December 1, 2015 Content source: Division of Cancer Prevention and ...

Cancer and Women

MedlinePlus

... Radon What We Know What States Can Do Case Study: Reducing Radon in Illinois What Comprehensive Cancer Control ... ePub file RIS file Page last reviewed: May 1, 2018 Page last updated: May 1, 2018 Content ...

Drug Testing of Students in Extracurricular Activities: An Update.

ERIC Educational Resources Information Center

Mawdsley, Ralph D.; Russo, Charles J.

2001-01-01

Reviews recent federal appellate court cases dealing with legal issues involving random drug testing of students participating in extracurricular activities. Draws implications for school business officials and other educators. (PKP)

Modeling of reservoir compaction and surface subsidence at South Belridge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, K.S.; Chan, C.K.; Prats, M.

1995-08-01

Finite-element models of depletion-induced reservoir compaction and surface subsidence have been calibrated with observed subsidence, locations of surface fissures, and regions of subsurface casing damage at South Belridge and used predictively for the evaluation of alternative reservoir-development plans. Pressure maintenance through diatomite waterflooding appears to be a beneficial means of minimizing additional subsidence and fissuring as well as reducing axial-compressive-type casing damage.

Integration of a supersonic unsteady aerodynamic code into the NASA FASTEX system

NASA Technical Reports Server (NTRS)

Appa, Kari; Smith, Michael J. C.

1987-01-01

A supersonic unsteady aerodynamic loads prediction method based on the constant pressure method was integrated into the NASA FASTEX system. The updated FASTEX code can be employed for aeroelastic analyses in subsonic and supersonic flow regimes. A brief description of the supersonic constant pressure panel method, as applied to lifting surfaces and body configurations, is followed by a documentation of updates required to incorporate this method in the FASTEX code. Test cases showing correlations of predicted pressure distributions, flutter solutions, and stability derivatives with available data are reported.

Testing the effectiveness of simplified search strategies for updating systematic reviews.

PubMed

Rice, Maureen; Ali, Muhammad Usman; Fitzpatrick-Lewis, Donna; Kenny, Meghan; Raina, Parminder; Sherifali, Diana

2017-08-01

The objective of the study was to test the overall effectiveness of a simplified search strategy (SSS) for updating systematic reviews. We identified nine systematic reviews undertaken by our research group for which both comprehensive and SSS updates were performed. Three relevant performance measures were estimated, that is, sensitivity, precision, and number needed to read (NNR). The update reference searches for all nine included systematic reviews identified a total of 55,099 citations that were screened resulting in final inclusion of 163 randomized controlled trials. As compared with reference search, the SSS resulted in 8,239 hits and had a median sensitivity of 83.3%, while precision and NNR were 4.5 times better. During analysis, we found that the SSS performed better for clinically focused topics, with a median sensitivity of 100% and precision and NNR 6 times better than for the reference searches. For broader topics, the sensitivity of the SSS was 80% while precision and NNR were 5.4 times better compared with reference search. SSS performed well for clinically focused topics and, with a median sensitivity of 100%, could be a viable alternative to a conventional comprehensive search strategy for updating this type of systematic reviews particularly considering the budget constraints and the volume of new literature being published. For broader topics, 80% sensitivity is likely to be considered too low for a systematic review update in most cases, although it might be acceptable if updating a scoping or rapid review. Copyright © 2017 Elsevier Inc. All rights reserved.

[Ophthalmological opinions for liability affairs material damage (Part I) (author's transl)].

PubMed

Burggraf, H

1979-02-01

German law abides anyone reponsible for the damage he or she has caused to another person's property or corporal integrity. This includes all medical costs directed towards the restitution of health as well as economical damage in direct consequence of the corporal damage. An ophthalmological expert is to state his opinion therefore in accordance with the specific conditions of every individual case and not just according to general charts. Financial compensation is only granted for the actual results of damage inquestion. Prior damage and disability have to be remarked but not to justify a financial compensation. The question of smart-money is dealt with in Part II.

On high explosive launching of projectiles for shock physics experiments

NASA Astrophysics Data System (ADS)

Swift, Damian C.; Forest, Charles A.; Clark, David A.; Buttler, William T.; Marr-Lyon, Mark; Rightley, Paul

2007-06-01

The hydrodynamic operation of the "Forest Flyer" type of explosive launching system for shock physics projectiles was investigated in detail using one and two dimensional continuum dynamics simulations. The simulations were numerically converged and insensitive to uncertainties in the material properties; they reproduced the speed of the projectile and the shape of its rear surface. The most commonly used variant, with an Al alloy case, was predicted to produce a slightly curved projectile, subjected to some shock heating and likely exhibiting some porosity from tensile damage. The curvature is caused by a shock reflected from the case; tensile damage is caused by the interaction of the Taylor wave pressure profile from the detonation wave with the free surface of the projectile. The simulations gave only an indication of tensile damage in the projectile, as damage is not understood well enough for predictions in this loading regime. The flatness can be improved by using a case of lower shock impedance, such as polymethyl methacrylate. High-impedance cases, including Al alloys but with denser materials improving the launching efficiency, can be used if designed according to the physics of oblique shock reflection, which indicates an appropriate case taper for any combination of explosive and case material. The tensile stress induced in the projectile depends on the relative thickness of the explosive, expansion gap, and projectile. The thinner the projectile with respect to the explosive, the smaller the tensile stress. Thus if the explosive is initiated with a plane wave lens, the tensile stress is lower than that for initiation with multiple detonators over a plane. The previous plane wave lens designs did, however, induce a tensile stress close to the spall strength of the projectile. The tensile stress can be reduced by changes in the component thicknesses. Experiments verifying the operation of explosively launched projectiles should attempt to measure porosity induced in the projectile: arrival time measurements are likely to be insensitive to porous regions caused by damaged or recollected material.

Data Updating Methods for Spatial Data Infrastructure that Maintain Infrastructure Quality and Enable its Sustainable Operation

NASA Astrophysics Data System (ADS)

Murakami, S.; Takemoto, T.; Ito, Y.

2012-07-01

The Japanese government, local governments and businesses are working closely together to establish spatial data infrastructures in accordance with the Basic Act on the Advancement of Utilizing Geospatial Information (NSDI Act established in August 2007). Spatial data infrastructures are urgently required not only to accelerate computerization of the public administration, but also to help restoration and reconstruction of the areas struck by the East Japan Great Earthquake and future disaster prevention and reduction. For construction of a spatial data infrastructure, various guidelines have been formulated. But after an infrastructure is constructed, there is a problem of maintaining it. In one case, an organization updates its spatial data only once every several years because of budget problems. Departments and sections update the data on their own without careful consideration. That upsets the quality control of the entire data system and the system loses integrity, which is crucial to a spatial data infrastructure. To ensure quality, ideally, it is desirable to update data of the entire area every year. But, that is virtually impossible, considering the recent budget crunch. The method we suggest is to update spatial data items of higher importance only in order to maintain quality, not updating all the items across the board. We have explored a method of partially updating the data of these two geographical features while ensuring the accuracy of locations. Using this method, data on roads and buildings that greatly change with time can be updated almost in real time or at least within a year. The method will help increase the availability of a spatial data infrastructure. We have conducted an experiment on the spatial data infrastructure of a municipality using those data. As a result, we have found that it is possible to update data of both features almost in real time.

Radiation damage by light- and heavy-ion bombardment of single-crystal LiNbO₃

DOE PAGES

Huang, Hsu-Cheng; Zhang, Lihua; Malladi, Girish; ...

2015-04-14

In this work, a battery of analytical methods including in situ RBS/C, confocal micro-Raman, TEM/STEM, EDS, AFM, and optical microscopy were used to provide a comparative investigation of light- and heavy-ion radiation damage in single-crystal LiNbO₃. High (~MeV) and low (~100s keV) ion energies, corresponding to different stopping power mechanisms, were used and their associated damage events were observed. In addition, sequential irradiation of both ion species was also performed and their cumulative depth-dependent damage was determined. It was found that the contribution from electronic stopping by high-energy heavy ions gave rise to a lower critical fluence for damage formationmore » than for the case of low-energy irradiation. Such energy-dependent critical fluence of heavy-ion irradiation is two to three orders of magnitude smaller than that for the case of light-ion damage. In addition, materials amorphization and collision cascades were seen for heavy-ion irradiation, while for light ion, crystallinity remained at the highest fluence used in the experiment. The irradiation-induced damage is characterized by the formation of defect clusters, elastic strain, surface deformation, as well as change in elemental composition. In particular, the presence of nanometric-scale damage pockets results in increased RBS/C backscattered signal and the appearance of normally forbidden Raman phonon modes. The location of the highest density of damage is in good agreement with SRIM calculations. (author)« less

Radiation damage by light- and heavy-ion bombardment of single-crystal LiNbO₃

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Hsu-Cheng; Zhang, Lihua; Malladi, Girish

In this work, a battery of analytical methods including in situ RBS/C, confocal micro-Raman, TEM/STEM, EDS, AFM, and optical microscopy were used to provide a comparative investigation of light- and heavy-ion radiation damage in single-crystal LiNbO₃. High (~MeV) and low (~100s keV) ion energies, corresponding to different stopping power mechanisms, were used and their associated damage events were observed. In addition, sequential irradiation of both ion species was also performed and their cumulative depth-dependent damage was determined. It was found that the contribution from electronic stopping by high-energy heavy ions gave rise to a lower critical fluence for damage formationmore » than for the case of low-energy irradiation. Such energy-dependent critical fluence of heavy-ion irradiation is two to three orders of magnitude smaller than that for the case of light-ion damage. In addition, materials amorphization and collision cascades were seen for heavy-ion irradiation, while for light ion, crystallinity remained at the highest fluence used in the experiment. The irradiation-induced damage is characterized by the formation of defect clusters, elastic strain, surface deformation, as well as change in elemental composition. In particular, the presence of nanometric-scale damage pockets results in increased RBS/C backscattered signal and the appearance of normally forbidden Raman phonon modes. The location of the highest density of damage is in good agreement with SRIM calculations. (author)« less

Modeling of beam-induced damage of the LHC tertiary collimators

NASA Astrophysics Data System (ADS)

Quaranta, E.; Bertarelli, A.; Bruce, R.; Carra, F.; Cerutti, F.; Lechner, A.; Redaelli, S.; Skordis, E.; Gradassi, P.

2017-09-01

Modern hadron machines with high beam intensity may suffer from material damage in the case of large beam losses and even beam-intercepting devices, such as collimators, can be harmed. A systematic method to evaluate thresholds of damage owing to the impact of high energy particles is therefore crucial for safe operation and for predicting possible limitations in the overall machine performance. For this, a three-step simulation approach is presented, based on tracking simulations followed by calculations of energy deposited in the impacted material and hydrodynamic simulations to predict the thermomechanical effect of the impact. This approach is applied to metallic collimators at the CERN Large Hadron Collider (LHC), which in standard operation intercept halo protons, but risk to be damaged in the case of extraction kicker malfunction. In particular, tertiary collimators protect the aperture bottlenecks, their settings constrain the reach in β* and hence the achievable luminosity at the LHC experiments. Our calculated damage levels provide a very important input on how close to the beam these collimators can be operated without risk of damage. The results of this approach have been used already to push further the performance of the present machine. The risk of damage is even higher in the upgraded high-luminosity LHC with higher beam intensity, for which we quantify existing margins before equipment damage for the proposed baseline settings.

Sex and Sexuality and HIV

MedlinePlus

... Education Home HIV Meds Updates Online Courses (CME) Case Studies Journal Articles Glossary Quick References Quick References Home ... against HIV: oral contraceptive ("the pill") injectable contraceptive (shot) contraceptive implant IUD (intrauterine device) emergency contraception ("morning- ...

Amiodarone-Induced Thyroid Dysfunction: A Clinical Update.

PubMed

Elnaggar, Mohamed Nabil; Jbeili, Kahtan; Nik-Hussin, Nik; Kozhippally, Mohandas; Pappachan, Joseph M

2018-06-01

Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Amiodarone-induced hypothyroidism (AIH) is diagnosed and managed in the same way as a usual case of hypothyroidism. However, differential diagnosis and clinical management of amiodarone-induced thyrotoxicosis (AIT) subtypes can be challenging. With the aid of a case snippet, we update the current evidence for the diagnostic work up and management of patients with amiodarone-induced thyroid dysfunction in this article. © Georg Thieme Verlag KG Stuttgart · New York.

Nongenetic risk factors for holoprosencephaly: An updated review of the epidemiologic literature.

PubMed

Summers, April D; Reefhuis, Jennita; Taliano, Joanna; Rasmussen, Sonja A

2018-05-15

Holoprosencephaly (HPE) is a major structural birth defect of the brain that occurs in approximately 1 in 10,000 live births. Although some genetic causes of HPE are known, a substantial proportion of cases have an unknown etiology. Due to the low birth prevalence and rarity of exposure to many potential risk factors for HPE, few epidemiologic studies have had sufficient sample size to examine risk factors. A 2010 review of the literature identified several risk factors that had been consistently identified as occurring more frequently among cases of HPE, including maternal diabetes, twinning, and a predominance of females, while also identifying a number of potential risk factors that had been less widely studied. In this article, we summarize a systematic literature review conducted to update the evidence for nongenetic risk factors for HPE. © 2018 Wiley Periodicals, Inc.

A Upgrade of the Aeroheating Software "MINIVER"

NASA Technical Reports Server (NTRS)

Louderback, Pierce

2013-01-01

Many software packages assist engineers with performing flight vehicle analysis, but some of these packages have gone many years without updates or significant improvements to their workflows. One such software package, known as MINIVER, is a powerful yet lightweight tool used for aeroheating analyses. However, it is an aging program that has not seen major improvements within the past decade. As part of a collaborative effort with the Florida Institute of Technology, MINIVER has received a major user interface overhaul, a change in program language, and will be continually receiving updates to improve its capabilities. The user interface update includes a migration from a command-line interface to that of a graphical user interface supported in the Windows operating system. The organizational structure of the pre-processor has been transformed to clearly defined categories to provide ease of data entry. Helpful tools have been incorporated, including the ability to copy sections of cases as well as a generalized importer which aids in bulk data entry. A visual trajectory editor has been included, as well as a CAD Editor which allows the user to input simplified geometries in order to generate MINIVER cases in bulk. To demonstrate its continued effectiveness, a case involving the JAXA OREX flight vehicle will be included, providing comparisons to captured flight data as well as other computational solutions. The most recent upgrade effort incorporated the use of the CAD Editor, and current efforts are investigating methods to link MINIVER projects with SINDA/Fluint and Thermal Desktop.