Quercitrin Protects Skin from UVB-induced Oxidative Damage

PubMed Central

Yin, Yuanqin; Li, Wenqi; Son, Yong-Ok; Sun, Lijuan; Lu, Jian; Kim, Donghern; Wang, Xin; Yao, Hua; Wang, Lei; Pratheeshkumar, Poyil; Hitron, Andrew J; Luo, Jia; Gao, Ning; Shi, Xianglin; Zhang, Zhuo

2013-01-01

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. PMID:23545178

Quercitrin protects skin from UVB-induced oxidative damage.

PubMed

Yin, Yuanqin; Li, Wenqi; Son, Young-Ok; Sun, Lijuan; Lu, Jian; Kim, Donghern; Wang, Xin; Yao, Hua; Wang, Lei; Pratheeshkumar, Poyil; Hitron, Andrew J; Luo, Jia; Gao, Ning; Shi, Xianglin; Zhang, Zhuo

2013-06-01

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. Copyright © 2013 Elsevier Inc. All rights reserved.

Earthquake damage to transportation systems

USGS Publications Warehouse

McCullough, Heather

1994-01-01

Earthquakes represent one of the most destructive natural hazards known to man. A large magnitude earthquake near a populated area can affect residents over thousands of square kilometers and cause billions of dollars in property damage. Such an event can kill or injure thousands of residents and disrupt the socioeconomic environment for months, sometimes years. A serious result of a large-magnitude earthquake is the disruption of transportation systems, which limits post-disaster emergency response. Movement of emergency vehicles, such as police cars, fire trucks and ambulances, is often severely restricted. Damage to transportation systems is categorized below by cause including: ground failure, faulting, vibration damage, and tsunamis.

Damage prediction of 7025 aluminum alloy during equal-channel angular pressing

NASA Astrophysics Data System (ADS)

Ebrahimi, M.; Attarilar, Sh.; Gode, C.; Djavanroodi, F.

2014-10-01

Equal-channel angular pressing (ECAP) is a prominent technique that imposes severe plastic deformation into materials to enhance their mechanical properties. In this research, experimental and numerical approaches were utilized to investigate the mechanical properties, strain behavior, and damage prediction of ECAPed 7025 aluminum alloy in various conditions, such as die channel angle, outer corner angle, and friction coefficient. Experimental results indicate that, after the first pass, the yield strength, ultimate tensile strength, and hardness magnitude are improved by approximately 95%, 28%, and 48.5%, respectively, compared with the annealed state, mainly due to grain refinement during the deformation. Finite element analysis shows that the influence of die channel angle is more important than that of outer corner angle or friction coefficient on both the strain behavior and the damage prediction. Also, surface cracks are the main cause of damage during the ECAP process for every die channel angle except for 90°; however, the cracks initiated from the neighborhood of the central regions are the possible cause of damage in the ECAPed sample with the die channel angle of 90°.

31 CFR 50.80 - Federal cause of action and remedy.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) of this section shall exist only for causes of action for property damage, personal injury, or death... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Federal cause of action and remedy... RISK INSURANCE PROGRAM Federal Cause of Action; Approval of Settlements § 50.80 Federal cause of action...

Decision tree analysis of factors influencing rainfall-related building damage

NASA Astrophysics Data System (ADS)

Spekkers, M. H.; Kok, M.; Clemens, F. H. L. R.; ten Veldhuis, J. A. E.

2014-04-01

Flood damage prediction models are essential building blocks in flood risk assessments. Little research has been dedicated so far to damage of small-scale urban floods caused by heavy rainfall, while there is a need for reliable damage models for this flood type among insurers and water authorities. The aim of this paper is to investigate a wide range of damage-influencing factors and their relationships with rainfall-related damage, using decision tree analysis. For this, district-aggregated claim data from private property insurance companies in the Netherlands were analysed, for the period of 1998-2011. The databases include claims of water-related damage, for example, damages related to rainwater intrusion through roofs and pluvial flood water entering buildings at ground floor. Response variables being modelled are average claim size and claim frequency, per district per day. The set of predictors include rainfall-related variables derived from weather radar images, topographic variables from a digital terrain model, building-related variables and socioeconomic indicators of households. Analyses were made separately for property and content damage claim data. Results of decision tree analysis show that claim frequency is most strongly associated with maximum hourly rainfall intensity, followed by real estate value, ground floor area, household income, season (property data only), buildings age (property data only), ownership structure (content data only) and fraction of low-rise buildings (content data only). It was not possible to develop statistically acceptable trees for average claim size, which suggest that variability in average claim size is related to explanatory variables that cannot be defined at the district scale. Cross-validation results show that decision trees were able to predict 22-26% of variance in claim frequency, which is considerably better compared to results from global multiple regression models (11-18% of variance explained). Still, a large part of the variance in claim frequency is left unexplained, which is likely to be caused by variations in data at subdistrict scale and missing explanatory variables.

Research on the fundamental principles of China's marine invasive species prevention legislation.

PubMed

Bai, Jiayu

2014-12-15

China's coastal area is severely damaged by marine invasive species. Traditional tort theory resolves issues relevant to property damage or personal injuries, through which plaintiffs cannot cope with the ecological damage caused by marine invasive species. Several defects exist within the current legal regimes, such as imperfect management systems, insufficient unified technical standards, and unsound legal responsibility systems. It is necessary to pass legislation to prevent the ecological damage caused by marine invasive species. This investigation probes the fundamental principles needed for the administration and legislation of an improved legal framework to combat the problem of invasive species within China's coastal waters. Copyright © 2014 Elsevier Ltd. All rights reserved.

7 CFR 252.6 - Miscellaneous provisions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Miscellaneous provisions. (a) Improper distribution or loss of or damage to donated food. If a processor improperly distributes or uses any donated food, or causes loss of or damage to a donated food through its... commodity related funds, assets, or property in child nutrition programs. Whoever embezzles, willfully...

7 CFR 252.6 - Miscellaneous provisions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Miscellaneous provisions. (a) Improper distribution or loss of or damage to donated food. If a processor improperly distributes or uses any donated food, or causes loss of or damage to a donated food through its... commodity related funds, assets, or property in child nutrition programs. Whoever embezzles, willfully...

7 CFR 252.6 - Miscellaneous provisions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Miscellaneous provisions. (a) Improper distribution or loss of or damage to donated food. If a processor improperly distributes or uses any donated food, or causes loss of or damage to a donated food through its... commodity related funds, assets, or property in child nutrition programs. Whoever embezzles, willfully...

7 CFR 252.6 - Miscellaneous provisions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Miscellaneous provisions. (a) Improper distribution or loss of or damage to donated food. If a processor improperly distributes or uses any donated food, or causes loss of or damage to a donated food through its... commodity related funds, assets, or property in child nutrition programs. Whoever embezzles, willfully...

7 CFR 252.6 - Miscellaneous provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Miscellaneous provisions. (a) Improper distribution or loss of or damage to donated food. If a processor improperly distributes or uses any donated food, or causes loss of or damage to a donated food through its... commodity related funds, assets, or property in child nutrition programs. Whoever embezzles, willfully...

Cytotoxic and DNA-damaging properties of glyphosate and Roundup in human-derived buccal epithelial cells.

PubMed

Koller, Verena J; Fürhacker, Maria; Nersesyan, Armen; Mišík, Miroslav; Eisenbauer, Maria; Knasmueller, Siegfried

2012-05-01

Glyphosate (G) is the largest selling herbicide worldwide; the most common formulations (Roundup, R) contain polyoxyethyleneamine as main surfactant. Recent findings indicate that G exposure may cause DNA damage and cancer in humans. Aim of this investigation was to study the cytotoxic and genotoxic properties of G and R (UltraMax) in a buccal epithelial cell line (TR146), as workers are exposed via inhalation to the herbicide. R induced acute cytotoxic effects at concentrations > 40 mg/l after 20 min, which were due to membrane damage and impairment of mitochondrial functions. With G, increased release of extracellular lactate dehydrogenase indicative for membrane damage was observed at doses > 80 mg/l. Both G and R induced DNA migration in single-cell gel electrophoresis assays at doses > 20 mg/l. Furthermore, an increase of nuclear aberrations that reflect DNA damage was observed. The frequencies of micronuclei and nuclear buds were elevated after 20-min exposure to 10-20 mg/l, while nucleoplasmatic bridges were only enhanced by R at the highest dose (20 mg/l). R was under all conditions more active than its active principle (G). Comparisons with results of earlier studies with lymphocytes and cells from internal organs indicate that epithelial cells are more susceptible to the cytotoxic and DNA-damaging properties of the herbicide and its formulation. Since we found genotoxic effects after short exposure to concentrations that correspond to a 450-fold dilution of spraying used in agriculture, our findings indicate that inhalation may cause DNA damage in exposed individuals.

50 CFR 91.17 - Property insurance for contest entries.

Code of Federal Regulations, 2010 CFR

2010-10-01

... damage unless such is caused by Service or Department negligence or willful misconduct. The Service and Department reserve the right to determine whether negligence or willful misconduct led to artwork being... to be damaged by any negligence on our part. This waiver remains at our discretion. [71 FR 39015...

Advanced patrol routing with on-call response for effective resource management.

DOT National Transportation Integrated Search

2011-12-01

Traffic incidents not only greatly impact individuals, but also affect the general population. : Depending on the incident severity, incidents are likely to cause both private and public property : damage and possibly cause injury and fatalities. Due...

Method for detecting moment connection fracture using high-frequency transients in recorded accelerations

USGS Publications Warehouse

Rodgers, J.E.; Elebi, M.

2011-01-01

The 1994 Northridge earthquake caused brittle fractures in steel moment frame building connections, despite causing little visible building damage in most cases. Future strong earthquakes are likely to cause similar damage to the many un-retrofitted pre-Northridge buildings in the western US and elsewhere. Without obvious permanent building deformation, costly intrusive inspections are currently the only way to determine if major fracture damage that compromises building safety has occurred. Building instrumentation has the potential to provide engineers and owners with timely information on fracture occurrence. Structural dynamics theory predicts and scale model experiments have demonstrated that sudden, large changes in structure properties caused by moment connection fractures will cause transient dynamic response. A method is proposed for detecting the building-wide level of connection fracture damage, based on observing high-frequency, fracture-induced transient dynamic responses in strong motion accelerograms. High-frequency transients are short (<1 s), sudden-onset waveforms with frequency content above 25 Hz that are visually apparent in recorded accelerations. Strong motion data and damage information from intrusive inspections collected from 24 sparsely instrumented buildings following the 1994 Northridge earthquake are used to evaluate the proposed method. The method's overall success rate for this data set is 67%, but this rate varies significantly with damage level. The method performs reasonably well in detecting significant fracture damage and in identifying cases with no damage, but fails in cases with few fractures. Combining the method with other damage indicators and removing records with excessive noise improves the ability to detect the level of damage. ?? 2010 Elsevier B.V. All rights reserved.

76 FR 37267 - Safety Zone, Pantego Creek; Belhaven, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... obstructions to the waterway that may cause death, serious bodily harm, or property damage. Establishing a... notice and opportunity to comment when the agency for good cause finds that those procedures are... finds that good cause exists for not publishing a notice of proposed rulemaking (NPRM) with respect to...

Supply and demand analysis for flood insurance by using logistic regression model: case study at Citarum watershed in South Bandung, West Java, Indonesia

NASA Astrophysics Data System (ADS)

Sidi, P.; Mamat, M.; Sukono; Supian, S.

2017-01-01

Floods have always occurred in the Citarum river basin. The adverse effects caused by floods can cover all their property, including the destruction of houses. The impact due to damage to residential buildings is usually not small. Indeed, each of flooding, the government and several social organizations providing funds to repair the building. But the donations are given very limited, so it cannot cover the entire cost of repair was necessary. The presence of insurance products for property damage caused by the floods is considered very important. However, if its presence is also considered necessary by the public or not? In this paper, the factors that affect the supply and demand of insurance product for damaged building due to floods are analyzed. The method used in this analysis is the ordinal logistic regression. Based on the analysis that the factors that affect the supply and demand of insurance product for damaged building due to floods, it is included: age, economic circumstances, family situations, insurance motivations, and lifestyle. Simultaneously that the factors affecting supply and demand of insurance product for damaged building due to floods mounted to 65.7%.

Quercitrin protects skin from UVB-induced oxidative damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yin, Yuanqin; Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY; Li, Wenqi

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidativemore » damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. - Highlights: • Oxidative stress plays a key role in UV-induced cell and tissue injuries. • Quercitrin decreases ROS generation and restores antioxidants irradiated by UVB. • Quercitrin reduces UVB-irradiated oxidative DNA damage, apoptosis, and inflammation. • Quercitrin functions as an antioxidant against UVB-induced skin injuries.« less

33 CFR 173.57 - Contents of report.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., fiberglass, or other), and year built (model year), of the reporting operator's vessel. (x) The name, address...) The nature and extent of each injury. (r) A description of all property damage and vessel damage with... contributed to causing the casualty. (w) The make, model, type (open, cabin, house, or other), beam width at...

UVA-induced protection of skin through the induction of heme oxygenase-1.

PubMed

Xiang, Yuancai; Liu, Gang; Yang, Li; Zhong, Julia Li

2011-12-01

UVA (320-400 nm) and UVB (290-320 nm) are the major components of solar UV irradiation, which is associated with various pathological conditions. UVB causes direct damage to DNA of epidermal cells and is mainly responsible for erythema, immunosuppression, photoaging, and skin cancer. UVA has oxidizing properties that can cause damage or enhance UVB damaging effects on skin. On the other hand, UVA can also lead to high levels of heme oxygenase-1 (HO-1) expression of cells that can provide an antioxidant effect on skin as well as anti-inflammatory properties in mammals and rodents. Therefore, this review focuses on the potential protection of UVA wavebands for the skin immune response, instead of mechanisms that underlie UVA-induced damage. Also, the role of HO-1 in UVA-mediated protection against UVB-induced immunosuppression in skin will be summarized. Thus, this review facilitates further understanding of potential beneficial mechanisms of UVA irradiation, and using the longer UVA (UVA1, 340-400 nm) in combination with HO-1 for phototherapy and skin protection against sunlight exposure.

Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koller, Verena J., E-mail: verena.koller@meduniwien.ac.at; Auwärter, Volker, E-mail: volker.auwaerter@uniklinik-freiburg.de; Grummt, Tamara, E-mail: tamara.grummt@uba.de

Cannabicyclohexanol (CP-47,497-C8) is a representative of a group of cannabimimetic cyclohexylphenols which is added to herbal mixtures as a cannabis substitute since 2008. Although in the beginning CP-47,497-C8 was the main ingredient of “Spice” and similar products, it was partly replaced by aminoalkylindole-type cannabinoid receptor agonists like JWH-018, JWH-073 or JWH-250, but never completely disappeared from the market. Since information on its toxicological properties is scarce, we investigated the effects of the drug in human derived cell lines. The cytotoxic effects were studied in a panel of assays (SRB, XTT, LDHe and NR tests) in a buccal derived (TR146) andmore » a liver derived (HepG2) cell line. The strongest effects were seen in the two former assays at levels ≥ 7.5 μM indicating that the compound interferes with protein synthesis and causes membrane damage. In additional comet assays, DNA damage was detected at levels ≥ 10 μM. Experiments with lesion specific enzymes showed that these effects are not due to oxidative damage of DNA bases. The negative findings obtained in Salmonella/microsome assays and the positive results of micronucleus tests with the cell lines indicate that the compound does not cause gene mutations but acts on the chromosomal level. In contrast to other synthetic cannabinoids, no indication for estrogenic/antiestrogenic properties was seen in a luciferase assay with bone marrow derived U2-OS cells. In conclusion, our findings show that the drug has only weak cytotoxic properties. However, the induction of chromosomal damage indicates that it may cause adverse effects in users due to its impact on the stability of the genetic material. - Highlights: • We tested the toxic properties of a synthetic cannabinoid. • Acute cytotoxic effects were detected with doses ≥ 7 μM. • No hormonal effects were found. • DNA damage was detected at levels ≥ 10 μM in comet assay and micronucleus tests. • Effects in directly exposed tissues may occur in humans.« less

31 CFR 50.81 - State causes of action preempted.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false State causes of action preempted. 50.81 Section 50.81 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK.... All State causes of action of any kind for property damage, personal injury, or death arising out of...

31 CFR 50.81 - State causes of action preempted.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false State causes of action preempted. 50.81 Section 50.81 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK.... All State causes of action of any kind for property damage, personal injury, or death arising out of...

31 CFR 50.81 - State causes of action preempted.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false State causes of action preempted. 50.81 Section 50.81 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK.... All State causes of action of any kind for property damage, personal injury, or death arising out of...

31 CFR 50.81 - State causes of action preempted.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false State causes of action preempted. 50.81 Section 50.81 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK.... All State causes of action of any kind for property damage, personal injury, or death arising out of...

Development, characterization, and modeling of ballistic impact on composite laminates under compressive pre-stress

NASA Astrophysics Data System (ADS)

Kerr-Anderson, Eric

Structural composite laminates were ballistically impacted while under in-plane compressive pre-stress. Residual properties, damage characterization, and energy absorption were compared to determine synergistic effects of in-plane compressive pre-stress and impact velocity. A fixture was developed to apply in-plane compressive loads up to 30 tons to structural composites during an impact event using a single-stage light-gas gun. Observed failure modes included typical conical delamination, the development of an impact initiated shear crack (IISC), and the shear failure of a pre-stressed composite due to impact. It was observed that the compressive failure threshold quadratically decreased in relation to the impact velocity up to velocities that caused partial penetration. For all laminates impacted at velocities causing partial or full penetration up to 350 ms-1, the failure threshold was consistent and used as an experimental normalization. Samples impacted below 65% of the failure threshold witnessed no significant change in damage morphology or residual properties when compared to typical conical delamination. Samples impacted above 65% of the failure threshold witnessed additional damage in the form of a shear crack extending perpendicular to the applied load from the point of impact. The presence of an IISC reduced the residual properties and even caused failure upon impact at extreme combinations. Four failure envelopes have been established as: transient failure, steady state failure, impact initiated shear crack, and conical damage. Boundaries and empirically based equations for residual compressive strength have been developed for each envelope with relation to two E-glass/vinyl ester laminate systems. Many aspects of pre-stressed impact have been individually examined, but there have been no comprehensive examinations of pre-stressed impact. This research has resulted in the exploration and characterization of compressively pre-stressed damage for impact velocities resulting in reflection, partial penetration, and penetration at pre-stress levels resulting in conical damage, shear cracking, and failure.

18 CFR 12.35 - Specific inspection requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... from monitoring instruments; and (vi) The quality and adequacy of maintenance, surveillance, and... life or cause significant property damage, the independent consultant must evaluate the ability of... endanger the project works. (2) If structural failure would not present a hazard to human life of cause...

18 CFR 12.35 - Specific inspection requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... from monitoring instruments; and (vi) The quality and adequacy of maintenance, surveillance, and... life or cause significant property damage, the independent consultant must evaluate the ability of... endanger the project works. (2) If structural failure would not present a hazard to human life of cause...

[Ophthalmological opinions for liability affairs material damage (Part I) (author's transl)].

PubMed

Burggraf, H

1979-02-01

German law abides anyone reponsible for the damage he or she has caused to another person's property or corporal integrity. This includes all medical costs directed towards the restitution of health as well as economical damage in direct consequence of the corporal damage. An ophthalmological expert is to state his opinion therefore in accordance with the specific conditions of every individual case and not just according to general charts. Financial compensation is only granted for the actual results of damage inquestion. Prior damage and disability have to be remarked but not to justify a financial compensation. The question of smart-money is dealt with in Part II.

31 CFR 50.80 - Federal cause of action and remedy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Federal cause of action and remedy. 50.80 Section 50.80 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... 102 of the Act, there shall exist a Federal cause of action for property damage, personal injury, or...

31 CFR 50.80 - Federal cause of action and remedy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Federal cause of action and remedy. 50.80 Section 50.80 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... 102 of the Act, there shall exist a Federal cause of action for property damage, personal injury, or...

31 CFR 50.80 - Federal cause of action and remedy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Federal cause of action and remedy. 50.80 Section 50.80 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... 102 of the Act, there shall exist a Federal cause of action for property damage, personal injury, or...

31 CFR 50.80 - Federal cause of action and remedy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Federal cause of action and remedy. 50.80 Section 50.80 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... 102 of the Act, there shall exist a Federal cause of action for property damage, personal injury, or...

33 CFR 140.201 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OCS activities: (a) Death. (b) Injury resulting in substantial impairment of any bodily unit or function. (c) Fire which causes death, serious injury or property damage exceeding $25,000. (d) Oil...

Earthquakes in Ohio and Vicinity 1776-2007

USGS Publications Warehouse

Dart, Richard L.; Hansen, Michael C.

2008-01-01

This map summarizes two and a third centuries of earthquake activity. The seismic history consists of letters, journals, diaries, and newspaper and scholarly articles that supplement seismograph recordings (seismograms) dating from the early twentieth century to the present. All of the pre-instrumental (historical) earthquakes were large enough to be felt by people or to cause shaking damage to buildings and their contents. Later, widespread use of seismographs meant that tremors too small or distant to be felt could be detected and accurately located. Earthquakes are a legitimate concern in Ohio and parts of adjacent States. Ohio has experienced more than 160 felt earthquakes since 1776. Most of these events caused no damage or injuries. However, 15 Ohio earthquakes resulted in property damage and some minor injuries. The largest historic earthquake in the state occurred in 1937. This event had an estimated magnitude of 5.4 and caused considerable damage in the town of Anna and in several other western Ohio communities. The large map shows all historical and instrumentally located earthquakes from 1776 through 2007.

Detection of fungal damaged popcorn using image property covariance features

USDA-ARS?s Scientific Manuscript database

Covariance-matrix-based features were applied to the detection of popcorn infected by a fungus that cause a symptom called “blue-eye.” This infection of popcorn kernels causes economic losses because of their poor appearance and the frequently disagreeable flavor of the popped kernels. Images of ker...

"Stronger than the Storm": Keeping Infants and Young Children in Mind During the Response to Superstorm Sandy

ERIC Educational Resources Information Center

Costa, Gerard; Mulrooney, Kathleen; Spinazzola, Nicci

2013-01-01

Superstorm Sandy hit the coast of New Jersey with deadly force causing hundreds of miles of coastline damage, loss of homes, property and road damage, and power outages throughout the region. despite the state's strong disaster response network, most programs and responders have little background in supporting the needs of infants and very young…

[A Method Research on Environmental Damage Assessment of a Truck Rollover Pollution Incident].

PubMed

Cai, Feng; Zhao, Shi-ho; Chen, Gang-cai; Xian, Si-shu; Yang, Qing-ling; Zhou, Xian-jie; Yu, Hai

2015-05-01

With high occurrence of sudden water pollution incident, China faces an increasingly severe situation of water environment. In order to deter the acts of environmental pollution, ensure the damaged resources of environment can be restored and compensated, it is very critical to quantify the economic losses caused by the sudden water pollution incident. This paper took truck rollover pollution incidents in Chongqing for an example, established a set of evaluation method for quantifying the environmental damage, and then assessed the environmental damage by the method from four aspects, including the property damage, ecological environment and resources damages, the costs of administrative affairs in emergency disposal, and the costs of investigation and evaluation.

24 CFR 573.1 - Authority and purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD to guarantee loans made by financial institutions to certain nonprofit organizations to finance activities designed to remedy the damage and destruction to real and personal property caused by acts of...

24 CFR 573.1 - Authority and purpose.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD to guarantee loans made by financial institutions to certain nonprofit organizations to finance activities designed to remedy the damage and destruction to real and personal property caused by acts of...

Magnetic properties of a stainless steel irradiated with 6 MeV Xe ions

NASA Astrophysics Data System (ADS)

Xu, Chaoliang; Liu, Xiangbing; Qian, Wangjie; Li, Yuanfei

2017-11-01

Specimens of austenitic stainless steel were irradiated with 6 MeV Xe ions at room temperature to 2, 7, 15 and 25 dpa. The vibrating sample magnetometer (VSM), grazing incidence X-ray diffraction (GIXRD) and positron annihilation lifetime spectroscopy (PLS) were carried out to analysis the magnetic properties and microstructural variations. The magnetic hysteresis loops indicated that higher irradiation damage causes more significant magnetization phenomenon. The equivalent saturated magnetization Mes and coercive force Hc were obtained from magnetic hysteresis loops. It is indicated that the Mes increases with irradiation damage. While Hc increases first to 2 dpa and then decreases continuously with irradiation damage. The different contributions of irradiation defects and ferrite precipitates on Mes and Hc can explain these phenomena.

Visualization of interaction between inorganic nanoparticles and bacteria or fungi.

PubMed

Chwalibog, André; Sawosz, Ewa; Hotowy, Anna; Szeliga, Jacek; Mitura, Stanislaw; Mitura, Katarzyna; Grodzik, Marta; Orlowski, Piotr; Sokolowska, Aleksandra

2010-12-06

The objective of the present investigation was to evaluate the morphologic characteristics of self-assemblies of diamond (nano-D), silver (nano-Ag), gold (nano-Au), and platinum (nano-Pt) nanoparticles with Staphylococcus aureus (bacteria) and Candida albicans (fungi), to determine the possibility of constructing microorganism-nanoparticle vehicles. Hydrocolloids of individual nanoparticles were added to suspensions of S. aureus and C. albicans. Immediately after mixing, the samples were inspected by transmission electron microscopy. Visualization of the morphologic interaction between the nanoparticles and microorganisms showed that nano-D, which are dielectrics and exhibit a positive zeta potential, were very different from the membrane potentials of microorganisms, and uniformly surrounded the microorganisms, without causing visible damage and destruction of cells. All metal nanoparticles with negative zeta potential had cell damaging properties. Nano-Ag showed the properties of self-organization with the cells, disintegrating the cell walls and cytoplasmic membranes, and releasing a substance (probably cytoplasm) outside the cell. Arrangement of nano-Au with microorganisms did not create a system of self-organization, but instead a "noncontact" interaction between the nanoparticles and microorganisms was observed to cause damage to fungal cells. Nano-Pt caused both microorganisms to release a substance outside the cell and disintegrated the cytoplasmic membrane and cell wall. Nano-Ag, nano-Au, and nano-Pt (all metal nanoparticles) are harmful to bacteria and fungi. In contrast, nano-D bind closely to the surface of microorganisms without causing visible damage to cells, and demonstrating good self-assembling ability. The results indicate that both microorganisms could be used as potential carriers for nano-D.

Visualization of interaction between inorganic nanoparticles and bacteria or fungi

PubMed Central

Chwalibog, André; Sawosz, Ewa; Hotowy, Anna; Szeliga, Jacek; Mitura, Stanislaw; Mitura, Katarzyna; Grodzik, Marta; Orlowski, Piotr; Sokolowska, Aleksandra

2010-01-01

Purpose The objective of the present investigation was to evaluate the morphologic characteristics of self-assemblies of diamond (nano-D), silver (nano-Ag), gold (nano-Au), and platinum (nano-Pt) nanoparticles with Staphylococcus aureus (bacteria) and Candida albicans (fungi), to determine the possibility of constructing microorganism–nanoparticle vehicles. Methods Hydrocolloids of individual nanoparticles were added to suspensions of S. aureus and C. albicans. Immediately after mixing, the samples were inspected by transmission electron microscopy. Results Visualization of the morphologic interaction between the nanoparticles and microorganisms showed that nano-D, which are dielectrics and exhibit a positive zeta potential, were very different from the membrane potentials of microorganisms, and uniformly surrounded the microorganisms, without causing visible damage and destruction of cells. All metal nanoparticles with negative zeta potential had cell damaging properties. Nano-Ag showed the properties of self-organization with the cells, disintegrating the cell walls and cytoplasmic membranes, and releasing a substance (probably cytoplasm) outside the cell. Arrangement of nano-Au with microorganisms did not create a system of self-organization, but instead a “noncontact” interaction between the nanoparticles and microorganisms was observed to cause damage to fungal cells. Nano-Pt caused both microorganisms to release a substance outside the cell and disintegrated the cytoplasmic membrane and cell wall. Conclusion Nano-Ag, nano-Au, and nano-Pt (all metal nanoparticles) are harmful to bacteria and fungi. In contrast, nano-D bind closely to the surface of microorganisms without causing visible damage to cells, and demonstrating good self-assembling ability. The results indicate that both microorganisms could be used as potential carriers for nano-D. PMID:21270959

Genotoxic effect of ethacrynic acid and impact of antioxidants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ward, William M.; Hoffman, Jared D.; Loo, George, E-mail: g_loo@uncg.edu

It is known that ethacrynic acid (EA) decreases the intracellular levels of glutathione. Whether the anticipated oxidative stress affects the structural integrity of DNA is unknown. Therefore, DNA damage was assessed in EA-treated HCT116 cells, and the impact of several antioxidants was also determined. EA caused both concentration-dependent and time-dependent DNA damage that eventually resulted in cell death. Unexpectedly, the DNA damage caused by EA was intensified by either ascorbic acid or trolox. In contrast, EA-induced DNA damage was reduced by N-acetylcysteine and by the iron chelator, deferoxamine. In elucidating the DNA damage, it was determined that EA increased themore » production of reactive oxygen species, which was inhibited by N-acetylcysteine and deferoxamine but not by ascorbic acid and trolox. Also, EA decreased glutathione levels, which were inhibited by N-acetylcysteine. But, ascorbic acid, trolox, and deferoxamine neither inhibited nor enhanced the capacity of EA to decrease glutathione. Interestingly, the glutathione synthesis inhibitor, buthionine sulfoxime, lowered glutathione to a similar degree as EA, but no noticeable DNA damage was found. Nevertheless, buthionine sulfoxime potentiated the glutathione-lowering effect of EA and intensified the DNA damage caused by EA. Additionally, in examining redox-sensitive stress gene expression, it was found that EA increased HO-1, GADD153, and p21mRNA expression, in association with increased nuclear localization of Nrf-2 and p53 proteins. In contrast to ascorbic acid, trolox, and deferoxamine, N-acetylcysteine suppressed the EA-induced upregulation of GADD153, although not of HO-1. Overall, it is concluded that EA has genotoxic properties that can be amplified by certain antioxidants. - Highlights: • Ethacrynic acid (EA) caused cellular DNA damage. • EA-induced DNA damage was potentiated by ascorbic acid or trolox. • EA increased ROS production, not inhibited by ascorbic acid or trolox. • EA decreased glutathione levels, not prevented by ascorbic acid or trolox. • Buthionine sulfoxime intensified the DNA damage caused by EA.« less

Economic analysis of prescribed burning for wildfire management in Western Australia

Treesearch

Veronique Florec; David Pannell; Michael Burton; Joel Kelso; Drew Mellor; George Milne

2013-01-01

Wildfires can cause significant damage to ecosystems, life and property, and wildfire events that do not involve people and property are becoming rare. With the expansion of the rural– urban interface in Western Australia and elsewhere, objectives of life and property protection become more difficult to achieve. We applied the cost plus net value change (C+NVC) model...

Composite fibrous glaucoma drainage implant

NASA Astrophysics Data System (ADS)

Klapstova, A.; Horakova, J.; Shynkarenko, A.; Lukas, D.

2017-10-01

Glaucoma is a frequent reason of loss vision. It is usually caused by increased intraocular pressure leading to damage of optic nerve head. This work deals with the development of fibrous structure suitable for glaucoma drainage implants (GDI). Commercially produced metallic glaucoma implants are very effective in lowering intraocular pressure. However, these implants may cause adverse events such as damage to adjacent tissue, fibrosis, hypotony or many others [1]. The aim of this study is to reduce undesirable properties of currently produced drains and improve their properties by creating of the composite fibrous drain for achieve a normal intraocular pressure. Two types of electrospinning technologies were used for the production of very small tubular implants. First type was focused for production of outer part of tubular drain and the second type of electrospinning method made the inner part of shape follows the connections of both parts. Complete implant had a special properties suitable for drainage of fluid. Morphological parameters, liquid transport tests and in-vitro cell adhesion tests were detected.

[Most common skin disorders caused by excessive exposure to sunlight].

PubMed

Zitás, Éva; Mészáros, Judit

2016-01-17

The healing properties of sunlight has been known for millennia, however the gradual deterioration of the ozone layer and the increased use of sun tanning beds in recent decades are causing an increase in skin damaging ultraviolet exposure. In this article the most common photodermatoses and the principles of their treatments are reviewed.

A symmetry measure for damage detection with mode shapes

NASA Astrophysics Data System (ADS)

Chen, Justin G.; Büyüköztürk, Oral

2017-11-01

This paper introduces a feature for detecting damage or changes in structures, the continuous symmetry measure, which can quantify the amount of a particular rotational, mirror, or translational symmetry in a mode shape of a structure. Many structures in the built environment have geometries that are either symmetric or almost symmetric, however damage typically occurs in a local manner causing asymmetric changes in the structure's geometry or material properties, and alters its mode shapes. The continuous symmetry measure can quantify these changes in symmetry as a novel indicator of damage for data-based structural health monitoring approaches. This paper describes the concept as a basis for detecting changes in mode shapes and detecting structural damage. Application of the method is demonstrated in various structures with different symmetrical properties: a pipe cross-section with a finite element model and experimental study, the NASA 8-bay truss model, and the simulated IASC-ASCE structural health monitoring benchmark structure. The applicability and limitations of the feature in applying it to structures of varying geometries is discussed.

78 FR 29089 - Safety Zones; Hawaiian Island Commercial Harbors, HI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

..., cause millions of dollars in property damage, and alter sensitive ecologies. The tsunami generated by... individually or cumulatively have a significant effect on the human environment. This rule will evacuate...

Dental X-ray exposure and Alzheimer's disease: a hypothetical etiological association.

PubMed

Rodgers, Caroline C

2011-07-01

Despite the fact that Alzheimer's disease was identified more than 100 years ago, its cause remains elusive. Although the chance of developing Alzheimer's disease increases with age, it is not a natural consequence of aging. This article proposes that dental X-rays can damage microglia telomeres - the structures at the end of chromosomes that determine how many times cells divide before they die - causing them to age prematurely. Degenerated microglia lose their neuroprotective properties, resulting in the formation of neurofibrillary tau tangles and consequently, the neuronal death that causes Alzheimer's dementia. The hypothesis that Alzheimer's is caused specifically by microglia telomere damage would explain the delay of one decade or longer between the presence of Alzheimer's brain pathology and symptoms; telomere damage would not cause any change in microglial function, it would just reset the countdown clock so that senescence and apoptosis occurred earlier than they would have without the environmental insult. Once microglia telomere damage causes premature aging and death, the adjacent neurons are deprived of the physical support, maintenance and nourishment they require to survive. This sequence of events would explain why therapies and vaccines that eliminate amyloid plaques have been unsuccessful in stopping dementia. Regardless of whether clearing plaques is beneficial or harmful - which remains a subject of debate - it does not address the failing microglia population. If microglia telomere damage is causing Alzheimer's disease, self-donated bone marrow or dental pulp stem cell transplants could give rise to new microglia populations that would maintain neuronal health while the original resident microglia population died. Copyright © 2011 Elsevier Ltd. All rights reserved.

Study on Damage Mechanism of Ductile Cast Iron Cooling Stave

NASA Astrophysics Data System (ADS)

Wang, Cui; Zhang, Jianliang; Zuo, Haibin; Dai, Bing

The damage mechanism of ductile cast iron cooling stave applied to No.4 blast furnace of Guofeng steel was analyzed through damage investigation in details, the damage causes: high-temperature gas flow erosion, wear of burden, high-temperature ablation, carburizing damage, improper operation on blast furnace, etc. were given out both in macroscopic and microscopic views. It can be obtained from metallographic diagrams that the diameter of graphite nodules increases, the number per unit area reduces, and roundness declines, successively, from cold to hot surface, which are not conducive to stave longevity. In summary, the material for staves manufacture should be better in comprehensive mechanical properties to prolong the service life, thus making blast furnace long campaign.

Static and fatigue tensile properties of cross-ply laminates containing vascules for self-healing applications

NASA Astrophysics Data System (ADS)

Luterbacher, R.; Trask, R. S.; Bond, I. P.

2016-01-01

The effect of including hollow channels (vascules) within cross-ply laminates on static tensile properties and fatigue performance is investigated. No change in mechanical properties or damage formation is observed when a single vascule is included in the 0/90 interface, representing 0.5% of the cross sectional area within the specimen. During tensile loading, matrix cracks develop in the 90° layers leading to a reduction of stiffness and strength (defined as the loss of linearity) and a healing agent is injected through the vascules in order to heal them and mitigate the caused degradation. Two different healing agents, a commercial low viscosity epoxy resin (RT151, Resintech) and a toughened epoxy blend (bespoke, in-house formulation) have been used to successfully recover stiffness under static loading conditions. The RT151 system recovered 75% of the initial failure strength, whereas the toughened epoxy blend achieved a recovery of 67%. Under fatigue conditions, post healing, a rapid decay of stiffness was observed as the healed damage re-opened within the first 2500 cycles. This was caused by the high fatigue loading intensity, which was near the static failure strength of the healing resin. However, the potential for ameliorating (via self-healing or autonomous repair) more diffuse transverse matrix damage via a vascular network has been shown.

Impact resistance of fiber composite blades used in aircraft turbine engines

NASA Technical Reports Server (NTRS)

Friedrich, L. A.; Preston, J. L., Jr.

1973-01-01

Resistance of advanced fiber reinforced epoxy matrix composite materials to ballistic impact was investigated as a function of impacting projectile characteristics, and composite material properties. Ballistic impact damage due to normal impacts, was classified as transverse (stress wave delamination and splitting), penetrative, or structural (gross failure). Steel projectiles were found to be gelatin ice projectiles in causing penetrative damage leading to reduced tensile strength. Gelatin and ice projectiles caused either transverse or structural damage, depending upon projectile mass and velocity. Improved composite transverse tensile strength, use of dispersed ply lay-ups, and inclusion of PRD-49-1 or S-glass fibers correlated with improved resistance of composite materials to transverse damage. In non-normal impacts against simulated blade shapes, the normal velocity component of the impact was used to correlate damage results with normal impact results. Stiffening the leading edge of simulated blade specimens led to reduced ballistic damage, while addition of a metallic leading edge provided nearly complete protection against 0.64 cm diameter steel, and 1.27 cm diameter ice and gelatin projectiles, and partial protection against 2.54 cm diameter projectiles of ice and gelatin.

Naval Survivability and Susceptibility Reduction Study-Surface Ship

DTIC Science & Technology

2012-09-01

the ship, causing damage. There are four properties affecting the susceptibility of a ship. The first property is the ease at which the ship can be...will affect how easily she can be detected. The second property is the ease at which the ship can be effective tracked, identified and classified by...being tracked by the active sensor after the she had been detected (PT|D). The third property is the ability to avoid being targeted. Again this is

26 CFR 1.270-1 - Limitation on deductions allowable to individuals in certain cases.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Losses and expenses of the trade or business of farming which are directly attributable to drought, (v... attributable to drought conditions and not to other causes such as faulty management or unfavorable market... for damages to or destruction of property as a result of drought conditions, if such property is used...

SITE AMPLIFICATION OF EARTHQUAKE GROUND MOTION.

USGS Publications Warehouse

Hays, Walter W.

1986-01-01

When analyzing the patterns of damage in an earthquake, physical parameters of the total earthquake-site-structure system are correlated with the damage. Soil-structure interaction, the cause of damage in many earthquakes, involves the frequency-dependent response of both the soil-rock column and the structure. The response of the soil-rock column (called site amplification) is controversial because soil has strain-dependent properties that affect the way the soil column filters the input body and surface seismic waves, modifying the amplitude and phase spectra and the duration of the surface ground motion.

Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, Karen L.; Dashner, Erica J.; Tsosie, Ranalda

Uranium has radiological and non-radiological effects within biological systems and there is increasing evidence for genotoxic and carcinogenic properties attributable to uranium through its heavy metal properties. In this study, we report that low concentrations of uranium (as uranyl acetate; < 10 μM) is not cytotoxic to human embryonic kidney cells or normal human keratinocytes; however, uranium exacerbates DNA damage and cytotoxicity induced by hydrogen peroxide, suggesting that uranium may inhibit DNA repair processes. Concentrations of uranyl acetate in the low micromolar range inhibited the zinc finger DNA repair protein poly(ADP-ribose) polymerase (PARP)-1 and caused zinc loss from PARP-1 protein.more » Uranyl acetate exposure also led to zinc loss from the zinc finger DNA repair proteins Xeroderma Pigmentosum, Complementation Group A (XPA) and aprataxin (APTX). In keeping with the observed inhibition of zinc finger function of DNA repair proteins, exposure to uranyl acetate enhanced retention of induced DNA damage. Co-incubation of uranyl acetate with zinc largely overcame the impact of uranium on PARP-1 activity and DNA damage. These findings present evidence that low concentrations of uranium can inhibit DNA repair through disruption of zinc finger domains of specific target DNA repair proteins. This may provide a mechanistic basis to account for the published observations that uranium exposure is associated with DNA repair deficiency in exposed human populations. - Highlights: • Low micromolar concentration of uranium inhibits polymerase-1 (PARP-1) activity. • Uranium causes zinc loss from multiple DNA repair proteins. • Uranium enhances retention of DNA damage caused by ultraviolet radiation. • Zinc reverses the effects of uranium on PARP activity and DNA damage repair.« less

USDA Forest Products Laboratory's Debris Launcher

Treesearch

James J. Bridwell; Robert J. Ross; Zhiyong Cai; David E. Kretschmann

2013-01-01

Throughout the United States, hundreds of tornados and several hurricanes affect people’s livelihoods each year. These natural disasters not only cause structural damage to property, they also cause numerous injuries, and regrettably, far too many deaths of people caught in their path. In an effort to increase the probability of surviving the strong winds and...

Spatiotemporal variability of hydrometeorological extremes and their impacts in the Jihlava region in the 1650-1880 period

NASA Astrophysics Data System (ADS)

Dolak, Lukas; Brazdil, Rudolf; Chroma, Katerina; Valasek, Hubert; Reznickova, Ladislava

2017-04-01

Different documentary evidence (taxation records, chronicles, insurance reports etc.) and secondary sources (peer-reviewed papers, historical literature, newspapers) are used for reconstruction of hydrometeorological extremes (HMEs) in the former Jihlava region in the 1651-1880 period. The study describes the system of tax alleviation in Moravia, presents assessment of the impacts of HMEs with regard to physical-geographical characteristic of area studied, presents up to now non-utilized documentary evidence (early fire and hail damage insurance claims) and application of the new methodological approaches for the analysis of HMEs impacts. During the period studied more than 500 HMEs were analysed for the 19 estates (past basic economic units) in the region. Thunderstorm in 1651 in Rančířov (the Jihlava estate), which caused damage on the fields and meadows, is the first recorded extreme event. Downpours causing flash floods and hailstorms are the most frequently recorded natural disasters. Together with floods, droughts, windstorms, blizzards, late frosts and lightning strikes starting fires caused enormous damage as well. The impacts of HMEs are classified into three categories: impacts on agricultural production, material property and the socio-economic impacts. Natural disasters became the reasons of losses of human lives, property, supplies and farming equipment. HMEs caused damage to fields and meadows, depletion of livestock and triggered the secondary consequences as lack of seeds and finance, high prices, indebtedness, poverty and deterioration in field fertility. The results are discussed with respect to uncertainties associated with documentary evidences and their spatiotemporal distribution. The paper shows that particularly archival records, preserved in the Moravian Land Archives in Brno and other district archives, represent a unique source of data contributing to the better understanding of extreme events and their impacts in the past.

Hydrometeorological extremes reconstructed from documentary evidence for the Jihlava region in the 17th-19th centuries

NASA Astrophysics Data System (ADS)

Dolak, Lukas; Brazdil, Rudolf; Chroma, Katerina; Valasek, Hubert; Belinova, Monika; Reznickova, Ladislava

2016-04-01

Different documentary evidence (taxation records, chronicles, insurance reports etc.) is used for reconstruction of hydrometeorological extremes (HMEs) in the Jihlava region (central part of the recent Czech Republic) in the 17th-19th centuries. The aim of the study is description of the system of tax alleviation in Moravia, presentation of utilization of early fire and hail damage insurance claims and application of the new methodological approaches for the analysis of HMEs impacts. During the period studied more than 400 HMEs were analysed for the 16 estates (past basic economic units). Late frost on 16 May 1662 on the Nove Mesto na Morave estate, which destroyed whole cereals and caused damage in the forests, is the first recorded extreme event. Downpours causing flash floods and hailstorms are the most frequently recorded natural disasters. Moreover, floods, droughts, windstorms, blizzards, late frosts and lightning strikes starting fires caused enormous damage as well. The impacts of HMEs are classified into three categories: impacts on agricultural production, material property and the socio-economic impacts. Natural disasters became the reasons of losses of human lives, property, supplies and farming equipment. HMEs caused damage to fields and meadows, depletion of livestock and triggered the secondary consequences as lack of seeds and finance, high prices, indebtedness, poverty and deterioration in field fertility. The results are discussed with respect to uncertainties associated with documentary evidences and their spatiotemporal distribution. Archival records, preserved in the Moravian Land Archives in Brno and other district archives, create a unique source of data contributing to the better understanding of extreme events and their impacts.

Study on quantitative risk assessment model of the third party damage for natural gas pipelines based on fuzzy comprehensive assessment

NASA Astrophysics Data System (ADS)

Qiu, Zeyang; Liang, Wei; Wang, Xue; Lin, Yang; Zhang, Meng

2017-05-01

As an important part of national energy supply system, transmission pipelines for natural gas are possible to cause serious environmental pollution, life and property loss in case of accident. The third party damage is one of the most significant causes for natural gas pipeline system accidents, and it is very important to establish an effective quantitative risk assessment model of the third party damage for reducing the number of gas pipelines operation accidents. Against the third party damage accident has the characteristics such as diversity, complexity and uncertainty, this paper establishes a quantitative risk assessment model of the third party damage based on Analytic Hierarchy Process (AHP) and Fuzzy Comprehensive Evaluation (FCE). Firstly, risk sources of third party damage should be identified exactly, and the weight of factors could be determined via improved AHP, finally the importance of each factor is calculated by fuzzy comprehensive evaluation model. The results show that the quantitative risk assessment model is suitable for the third party damage of natural gas pipelines and improvement measures could be put forward to avoid accidents based on the importance of each factor.

Out-of-plane properties

NASA Technical Reports Server (NTRS)

Jackson, Wade C.; Portanova, Marc A.

1995-01-01

This paper summarizes three areas of research which were performed to characterize out-of-plane properties of composite materials. In the first investigation, a series of tests was run to characterize the through-the-thickness tensile strength for a variety of composites that included 2D braids, 2D and 3D weaves, and prepreg tapes. A new test method based on a curved beam was evaluated. Failures were significantly different between the 2D materials and the 3D weaves. The 2D materials delaminated between layers due to out-of-plane tensile stresses while the 3D weaves failed due to the formation of radial cracks between the surface plies caused by high circumferential stresses along the inner radius. The strength of the 2D textile composites did not increase relative to the tapes. Final failure in the 3D weaves was caused by a circumferential crack similar to the 2D materials and occurred at a lower bending moment than in other materials. The early failures in the 3D weaves were caused by radial crack formation rather than a low through-the-thickness strength. The second investigation focused on the development of a standard impact test method to measure impact damage resistance. The only impact tests that currently exist are compression after impact (CAI) tests which incorporate elements of both damage resistance and damage tolerance. A new impact test method is under development which uses a quasi-static indentation (QSI) test to directly measure damage resistance. Damage resistance is quantified in terms of the contact force to produce a unit of damage where a metric for damage may be area in C-scan, depth of residual dent , penetration, damage growth, etc. A final draft of an impact standard that uses a QSI test method will be presented to the ASTM Impact Task Group on impact. In the third investigation, the impact damage resistance behavior of a variety of textile materials was studied using the QSI test method. In this study, the force where large damage initiates was measured and the delamination size as a function of force was determined. The force to initiate large damage was significantly lower in braids and weaves. The delamination diameter - impact forace relationship was quanitfied using a damage resistance parameter, Q(*), which related delamination diameter to imapct force over a range of delamination sizes. Using this Q(*) parameter to rate the materials, the stitched uniweaves, toughened epoxy tapes, and through-the-thickness orthogonal interlock weave were the most damage resistant.

Influence of Water Solute Exposure on the Chemical Evolution and Rheological Properties of Asphalt.

PubMed

Pang, Ling; Zhang, Xuemei; Wu, Shaopeng; Ye, Yong; Li, Yuanyuan

2018-06-11

The properties of asphalt pavement are damaged under the effects of moisture. The pH value and salt concentration of water are the key factors that affect the chemical and rheological properties of asphalt during moisture damage. Four kinds of water solutions, including distilled water, an acidic solution, alkaline solution and saline solution were used to investigate the effects of aqueous solute compositions on the chemical and rheological properties of asphalt. Thin-layer chromatography with flame ionization detection (TLC-FID), Fourier transform infrared (FTIR) spectroscopy and dynamic shear rheometer (DSR) were applied to investigate the components, chemistry and rheology characteristics of asphalt specimens before and after water solute exposure. The experimental results show that moisture damage of asphalt is not only associated with an oxidation process between asphalt with oxygen, but it is also highly dependent on some compounds of asphalt dissolving and being removed in the water solutions. In detail, after immersion in water solute, the fraction of saturates, aromatics and resins in asphalt binders decreased, while asphaltenes increased; an increase in the carbonyl and sulphoxide indices, and a decrease in the butadiene index were also found from the FTIR analyzer test. The rheological properties of asphalt are sensitive to water solute immersing. The addition of aqueous solutes causes more serious moisture damage on asphalt binders, with the pH11 solution presenting as the most destructive during water solute exposure.

Light triggered interfacial damage self-healing of poly(p-phenylene benzobisoxazole) fiber composites.

PubMed

Hu, Zhen; Shao, Qing; Huang, Yudong; Yu, Long; Zhang, Dayu; Xu, Xirong; Lin, Jing; Liu, Hu; Guo, Zhanhu

2018-05-04

The interfacial microcracks in the resin matrix composites are difficult to be detected and repaired. However, the self-healing concept provides opportunities to fabricate composites with unusual properties. In the present study, photothermal conversion Ag-Cu 2 S nanoparticles were immobilized onto poly(p-phenylene benzobisoxazole) (PBO) fibers via a polydopamine chemistry. Benefitting from the photothermal effects of Ag-Cu 2 S, the obtained PBO fibers (Ag-Cu 2 S-PBO) efficiently converted the light energy into heat under Xenon lamp irradiation. Then, single PBO fiber composites were prepared using thermoplastic polyurethane as the matrix. It was found that the interfacial damage caused by single fiber pull-out was simply self-healed by Xe light irradiation. This wonderful interfacial damage self-healing property was mainly attributed to the in situ heating generation via photothermal effects of Ag-Cu 2 S in the composite interface. This paper reports a novel strategy to construct advanced composites with light-triggered self-healing properties, which will provide inspiration for preparing high performance composite materials.

Light triggered interfacial damage self-healing of poly(p-phenylene benzobisoxazole) fiber composites

NASA Astrophysics Data System (ADS)

Hu, Zhen; Shao, Qing; Huang, Yudong; Yu, Long; Zhang, Dayu; Xu, Xirong; Lin, Jing; Liu, Hu; Guo, Zhanhu

2018-05-01

The interfacial microcracks in the resin matrix composites are difficult to be detected and repaired. However, the self-healing concept provides opportunities to fabricate composites with unusual properties. In the present study, photothermal conversion Ag-Cu2S nanoparticles were immobilized onto poly(p-phenylene benzobisoxazole) (PBO) fibers via a polydopamine chemistry. Benefitting from the photothermal effects of Ag-Cu2S, the obtained PBO fibers (Ag-Cu2S-PBO) efficiently converted the light energy into heat under Xenon lamp irradiation. Then, single PBO fiber composites were prepared using thermoplastic polyurethane as the matrix. It was found that the interfacial damage caused by single fiber pull-out was simply self-healed by Xe light irradiation. This wonderful interfacial damage self-healing property was mainly attributed to the in situ heating generation via photothermal effects of Ag-Cu2S in the composite interface. This paper reports a novel strategy to construct advanced composites with light-triggered self-healing properties, which will provide inspiration for preparing high performance composite materials.

Pear thrips damage and impact on the Vermont sugarmaker

Treesearch

Daniel B. Crocker

1991-01-01

I am a sugarmaker from southern Vermont. I became a sugarmaker because I wanted to establish a long-term project on my property from which I could make a living. The trees on my land are very healthy, as evidenced by the high volume of syrup I am able to produce. I have noticed the thrips damage for a number of years, but didn't know the cause until 1987. I would...

The Army Needs to Recoup Funds Expended on Property Damaged in an Accident at a Development Subcontractor’s Facility (Redacted)

DTIC Science & Technology

2012-05-24

liability for the JLENS prope1iy damaged in an accident at a subcontractor’s facility. The accident occmTed when high winds caused an Airship ...modernization proponent for space, high - altitude and global missile defense, is the Almy operational integrator for global missile defense, and conducts...Alexandria, VA 22350-1500 Acronyms and Abbreviations AMS Airship Management Services DCMA Defense Contract

3D lattice distortions and defect structures in ion-implanted nano-crystals

DOE PAGES

Hofmann, Felix; Robinson, Ian K.; Tarleton, Edmund; ...

2017-04-06

The ability of Focused Ion Beam (FIB) techniques to cut solid matter at the nano-scale revolutionized the study of material structure across the life-, earth- and material sciences. But a detailed understanding of the damage caused by the ion beam and its effect on material properties remains elusive. We examine this damage in 3D using coherent X-ray diffraction to measure the full lattice strain tensor in FIB-milled gold nano-crystals. We also found that even very low ion doses, previously thought to be negligible, cause substantial lattice distortions. At higher doses, extended self-organized defect structures appear. Combined with detailed numerical calculations,more » these observations allow fundamental insight into the nature of the damage created and the structural instabilities that lead to a surprisingly inhomogeneous morphology.« less

Research on the fragment impact resistance of a composite mast

NASA Astrophysics Data System (ADS)

Zhang, Wei; Wu, Chao; Yang, Wenshan; Xu, Shanshan; Ren, Shaofei

2011-09-01

Due to the unique structural mode and material property of a composite sandwich plate, related research such as fragment impact resistance of a composite mast is short of publication and urgent in this field. In this paper, the commonly accepted sandwich core board theory was modified. Damage caused by a fragment attack was simulated onto a sandwich plate model built with solid and shell elements. It was shown that shear failure and vast matrix cracking are the main reasons for outer coat damage, and tension failure and partial matrix cracking are the cause for inner coat damage. Additionally, according to complexities in actual sea battles, different work conditions of missile attacks were set. Ballistic limit values of different fragment sizes were also obtained, which provides references for enhancing the fragment impact resistance of a composite mast.

3D lattice distortions and defect structures in ion-implanted nano-crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmann, Felix; Robinson, Ian K.; Tarleton, Edmund

The ability of Focused Ion Beam (FIB) techniques to cut solid matter at the nano-scale revolutionized the study of material structure across the life-, earth- and material sciences. But a detailed understanding of the damage caused by the ion beam and its effect on material properties remains elusive. We examine this damage in 3D using coherent X-ray diffraction to measure the full lattice strain tensor in FIB-milled gold nano-crystals. We also found that even very low ion doses, previously thought to be negligible, cause substantial lattice distortions. At higher doses, extended self-organized defect structures appear. Combined with detailed numerical calculations,more » these observations allow fundamental insight into the nature of the damage created and the structural instabilities that lead to a surprisingly inhomogeneous morphology.« less

Ultra-high Speed Optical Imaging of Ultrasound-activated Microbubbles in Mesenteric Microvessels

NASA Astrophysics Data System (ADS)

Chen, Hong

Ultrasound contrast agent microbubbles have gained widespread applications in diagnostic and therapeutic ultrasound. Animal studies of bioeffects induced by ultrasound-activated microbubbles have demonstrated that microbubbles can cause microvessel damage. Much scientific attention has been attracted to such microvascular bioeffects, not only because of the related safety concerns, but also because of the potential useful applications of microbubbles in the intravascular delivery of drugs and genetic materials into target tissues. A significant challenge in using microbubbles in medical ultrasound is the lack of knowledge about how the microbubbles behave in blood vessels when exposed to ultrasound and how their interactions with ultrasound cause vascular damage. Although extensive studies were performed in the past to study the dynamics of microbubbles, most of those studies were performed in vitro and did not directly address the clinical environment in which microbubbles are injected into blood vessels. In this thesis work, a synchronized optical-acoustic system was set up for ultrahigh speed imaging of insonated microbubbles in microvessels. The recorded images revealed the formation of microjets penetrating the microbubbles, as well as vessel distention (motion outward against the surrounding tissue) and vessel invagination (motion inward toward the lumen) caused by the expansion and collapse of the microbubbles, respectively. Contrary to current paradigms which propose that microbubbles damage vessels either by distending them or by forming liquid jets impinging on them, microbubbles translation and jetting were in the direction away from the nearest vessel wall; furthermore, invagination typically exceeded distention in arterioles and venules. Vessel invagination was found to be associated with vascular damage. These studies suggest that vessel invagination may be a newly discovered potential mechanism for vascular damage by ultrasound-activated microbubbles. The dynamics of bubble-vessel interactions are coupled intimately with the viscoelastic properties of the microvessels. To probe these properties, a method based on the relaxation times of the invaginated microvessels was used to estimate the relaxation time constants of the microvessels. It was found that the time constants were on microsecond time scales, which provided insight into the unique and unknown viscoelastic properties of the microvessels.

MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity.

PubMed

Thomas, David M; Kuhn, Donald M

2005-07-19

Methamphetamine causes long-term toxicity to dopamine nerve endings of the striatum. Evidence is emerging that microglia can contribute to the neuronal damage associated with disease, injury, or inflammation, but their role in methamphetamine-induced neurotoxicity has received relatively little attention. Lipopolysaccharide (LPS) and the neurotoxic HIV Tat protein, which cause dopamine neuronal toxicity after direct infusion into brain, cause activation of cultured mouse microglial cells as evidenced by increased expression of intracellular cyclooxygenase-2 and elevated secretion of tumor necrosis factor-alpha. MK-801, a non-competitive NMDA receptor antagonist that is known to protect against methamphetamine neurotoxicity, prevents microglial activation by LPS and HIV Tat. Dextromethorphan, an antitussive agent with NMDA receptor blocking properties, also prevents microglial activation. In vivo, MK-801 and dextromethorphan reduce methamphetamine-induced activation of microglia in striatum and they protect dopamine nerve endings against drug-induced nerve terminal damage. The present results indicate that the ability of MK-801 and dextromethorphan to protect against methamphetamine neurotoxicity is related to their common property as blockers of microglial activation.

78 FR 56912 - Notice of Regulatory Waiver Requests Granted for the Second Quarter of Calendar Year 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-16

... the devastation caused by Hurricanes Katrina, Rita and Gustav. The City is located within a declared..., 2013. Reason Waived: The SJBPHA requested a waiver due to severe property damage from Hurricane Isaac...

BROMINATED FLAME RETARDANTS: CAUSE FOR CONCERN?

EPA Science Inventory

Brominated flame retardants (BFRs) have routinely been added to consumer products for several decades in a successful effort to reduce fire-related injury and property damage. Recently, concern for this emerging class of chemicals has risen due to the occurrence of several class...

Identifying Hail Signatures in Satellite Imagery from the 9-10 August 2011 Severe Weather Event

NASA Technical Reports Server (NTRS)

Dryden, Rachel L.; Molthan, Andrew L.; Cole, Tony A.; Bell, Jordan

2014-01-01

Severe thunderstorms can produce large hail that causes property damage, livestock fatalities, and crop failure. However, detailed storm surveys of hail damage conducted by the National Weather Service (NWS) are not required. Current gaps also exist between Storm Prediction Center (SPC) hail damage estimates and crop-insurance payouts. NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard the Terra and Aqua satellites can be used to support NWS damage assessments, particularly to crops during the growing season. The two-day severe weather event across western Nebraska and central Kansas during 9-10 August 2011 offers a case study for investigating hail damage signatures by examining changes in Normalized Difference Vegetation Index (NDVI) derived from MODIS imagery. By analyzing hail damage swaths in satellite imagery, potential economic losses due to crop damage can be quantified and further improve the estimation of weather impacts on agriculture without significantly increasing manpower requirements.

On the classification of normalized natural frequencies for damage detection in cantilever beam

NASA Astrophysics Data System (ADS)

Dahak, Mustapha; Touat, Noureddine; Benseddiq, Noureddine

2017-08-01

The presence of a damage on a beam causes changes in the physical properties, which introduce flexibility, and reduce the natural frequencies of the beam. Based on this, a new method is proposed to locate the damage zone in a cantilever beam. In this paper, the cantilever beam is discretized into a number of zones, where each zone has a specific classification of the first four normalized natural frequencies. The damaged zone is distinguished by only the classification of the normalized frequencies of the structure. In the case when the damage is symmetric to the vibration node, we use the unchanged natural frequency as a second information to obtain a more accurate location. The effectiveness of the proposed method is shown by a numerical simulation with ANSYS software and experimental investigation of a cantilever beam with different damage.

32 CFR 750.54 - Payment of costs, settlements, and judgments related to certain medical or legal malpractice claims.

Code of Federal Regulations, 2013 CFR

2013-07-01

... cognizable under 10 U.S.C. 1089(f) [for personal injury or death caused by any physician, dentist, nurse... assistants, and therapists)] or 10 U.S.C. 1054(f) (for damages for injury or loss of property caused by any... health care functions or legal services and within the scope of employment; and (2) Such personnel...

32 CFR 750.54 - Payment of costs, settlements, and judgments related to certain medical or legal malpractice claims.

Code of Federal Regulations, 2014 CFR

2014-07-01

... cognizable under 10 U.S.C. 1089(f) [for personal injury or death caused by any physician, dentist, nurse... assistants, and therapists)] or 10 U.S.C. 1054(f) (for damages for injury or loss of property caused by any... health care functions or legal services and within the scope of employment; and (2) Such personnel...

32 CFR 750.54 - Payment of costs, settlements, and judgments related to certain medical or legal malpractice claims.

Code of Federal Regulations, 2011 CFR

2011-07-01

... cognizable under 10 U.S.C. 1089(f) [for personal injury or death caused by any physician, dentist, nurse... assistants, and therapists)] or 10 U.S.C. 1054(f) (for damages for injury or loss of property caused by any... health care functions or legal services and within the scope of employment; and (2) Such personnel...

32 CFR 750.54 - Payment of costs, settlements, and judgments related to certain medical or legal malpractice claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... cognizable under 10 U.S.C. 1089(f) [for personal injury or death caused by any physician, dentist, nurse... assistants, and therapists)] or 10 U.S.C. 1054(f) (for damages for injury or loss of property caused by any... health care functions or legal services and within the scope of employment; and (2) Such personnel...

32 CFR 750.54 - Payment of costs, settlements, and judgments related to certain medical or legal malpractice claims.

Code of Federal Regulations, 2012 CFR

2012-07-01

... cognizable under 10 U.S.C. 1089(f) [for personal injury or death caused by any physician, dentist, nurse... assistants, and therapists)] or 10 U.S.C. 1054(f) (for damages for injury or loss of property caused by any... health care functions or legal services and within the scope of employment; and (2) Such personnel...

On the mechanical properties of tooth enamel under spherical indentation.

PubMed

Chai, Herzl

2014-11-01

The mechanical properties of tooth enamel generally exhibit large variations, which reflect its structural and material complexity. Some key properties were evaluated under localized contact, simulating actual functioning conditions. Prominent cusps of extracted human molar teeth were polished down ~0.7 mm below the cusp tip and indented by tungsten carbide balls. The internal damage was assessed after unloading from longitudinal or transverse sections. The ultimate tensile stress (UTS) was determined using a novel bilayer specimen. The damage is characterized by penny-like radial cracks driven by hoop stresses and cylindrical cracks driven along protein-rich interrod materials by shear stresses. Shallow cone cracks typical of homogeneous materials which may cause rapid tooth wear under repeat contact are thus avoided. The mean stress vs. indentation strain curve is highly nonlinear, attributable to plastic shearing of protein between and within enamel rods. This curve is also affected by damage, especially radial cracks, the onset of which depends on ball radius. Several material properties were extracted from the tests, including shear strain at the onset of ring cracks γ(F) (=0.14), UTS (=119 MPa), toughness K(C) (=0.94 MPa m(1/2)), a crack propagation law and a constitutive response determined by trial and error with the aid of a finite-element analysis. These quantities, which are only slightly sensitive to anatomical location within the enamel region tested, facilitate a quantitative assessment of crown failure. Causes for variations in published UTS and K(C) values are discussed. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Correlation of fully-softened shear strength of clay soil with index properties : phase I.

DOT National Transportation Integrated Search

2010-09-01

Shallow slope failures in clay soils cause many millions of dollars of damage annually on highway : embankments and cut slopes and necessitate difficult and expensive repairs that negatively : impact budgets, traffic flow, and the environment. The em...

75 FR 24820 - Federal Management Regulation; Replacement of Personal Property Pursuant to the Exchange/Sale...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... of damage caused by, for example, natural disaster or accident, should also be eligible for exchange... natural disaster); or (3) Scrap gold for fine gold. * * * * * Sec. 102-39.80 [Amended] 0 3. Amend Sec. 102...

EDA's post-disaster assistance program after hurricane Andrew : final report.

DOT National Transportation Integrated Search

1996-03-01

Hurricane Andrew devastated parts of South Florida in August 1992, causing $20 billion in property damage, killing at least 41 people, and injuring many more. EDA joined other federal agencies in the disaster recovery process by promptly sending a te...

Control of large commercial vehicle accidents caused by front tire failures.

DOT National Transportation Integrated Search

1975-08-01

The Federal Highway Administration of the u.s. Department of Transportation is concerned with the loss of life, injury, and property damage that result from front tire failure on heavyduty trucks. The Bureau of Motor Carrier Safety contracted with Ul...

Flood Losses Associated with Winter Storms in the U.S. Northeast

NASA Astrophysics Data System (ADS)

Ting, M.; Shimkus, C.

2015-12-01

Winter storms pose a number of hazards to coastal communities in the U.S. Northeast including heavy rain, snow, strong wind, cold temperatures, and flooding. These hazards can cause millions in property damages from one storm alone. This study addresses the impacts of winter storms from 2001 - 2012 on coastal counties in the U.S. Northeast and underscores the significant economic consequences extreme winter storms have on property. The analysis on the types of hazards (floods, strong wind, snow, etc.) and associated damage from the National Climatic Data Center Storm Events Database indicates that floods were responsible for the highest damages. This finding suggests that winter storm vulnerability could grow in the future as precipitation intensity increases and sea level rise exacerbate flood losses. Flood loss maps are constructed based on damage amount, which can be compared to the flood exposure maps constructed by the NOAA Office of Coastal Management. Interesting agreements and discrepancies exist between the two methods, which warrant further examination. Furthermore, flood losses often came from storms characterized as heavy precipitation storms and strong surge storms, and sometimes both, illustrating the compounding effect of flood risks in the region. While New Jersey counties experienced the most damage per unit area, there is no discernable connection between population density and damage amount, which suggests that societal impacts may rely less on population characteristics and more on infrastructure types and property values, which vary throughout the region.

Effects of the earthquake of March 27, 1964, at Whittier, Alaska: Chapter B in The Alaska earthquake, March 27, 1964: effects on communities

USGS Publications Warehouse

Kachadoorian, Reuben

1965-01-01

Whittier, Alaska, lying at the western end of Passage Canal, is an ocean terminal of The Alaska Railroad. The earthquake that shook south-central Alaska at 5:36 p.m. (Alaska Standard Time) on March 27, 1964, took the lives of 13 persons and caused more than $5 million worth of damage to Government and private property at Whittier. Seismic motion lasted only 2½-3 minutes, but when it stopped the Whittier waterfront was in shambles land the port facilities were inoperable. Damage was caused by (1) a 5.3-foot subsidence of the landmass, sufficient to put some of the developed land under water during high tides, (2) seismic shock, (3) fracturing of fill and unconsolidated sediments, (4) compaction of fill and unconsolidated deposits, (5) submarine landslides which generated waves that destroyed part of The Alaska Railroad roadbed and other property, (6) at least two, but probably three, waves generated by landslides, which completely wrecked the buildings of two lumber companies, the stub pier, the small-boat harbor, the car-barge slip dock, and several homes, and (7) fire that destroyed the fuel-storage tanks at the Whittier waterfront. Many buildings and other facilities were totally wrecked, others were damaged to lesser degrees. For example, the 14-story reinforced concrete Hodge Building, which rests upon at least 44 feet of sandy gravel, was moderately damaged by seismic shock, but the six-story reinforced-concrete Buckner Building, which rests upon bedrock, was only slightly damaged.

Observations and Modeling of Environmental and Human Damages by the 2004 Indian Ocean tsunami

NASA Astrophysics Data System (ADS)

Goto, K.; Imamura, F.; Koshimura, S.; Yanagisawa, H.

2008-05-01

On 26 December 2004, one of the largest tsunamis in human history (the 2004 Indian Ocean tsunami) struck coastal areas of countries surrounding the Indian Ocean, causing severe property damage and loss of life and causing us to think anew about the fearful consequences of a tsunami disaster. The tsunami devastated more than 10 countries around the ocean including Indonesia, Sri Lanka, India, and Thailand. Since its energy remains almost constant, the tsunami wave height grows tremendously in shallow water. It ranged in runups of ~48m on the western shore of Sumatra, ~18m in Thailand, and ~15m in Sri Lanka. The tsunami killed nearly 230,000 people, including visitors from foreign countries, resulting in great economic losses. The tsunami was also affected coastal environment at these countries and induced severe topographic change, and damages to the marine ecosystems as well as vegetations on land. Immediately following the tsunami, number of research teams has investigated damages of environment and human communities by tsunamis. Numerical analyses of tsunami propagation have also been carried out to understand the behavior and wave properties of tsunamis. However, there are few studies that focused on the integration of the field observations and numerical results, nevertheless that such analysis is critically important to evaluate the environmental and human damages by the tsunami. In this contribution, we first review damages to the environment and humans due to the 2004 Indian Ocean tsunami at Thailand, Indonesia, and Sri Lanka based on our field observations, and then we evaluate these damages based on high resolution numerical results. For example, we conducted field observation as well as high-resolution (17 m grid cells) numerical calculation for damages of corals (reef rocks) and mangroves at Pakarang Cape, Thailand. We found that hundreds of reef rocks were emplaced on the tidal bench, and 70 % of mangroves were destroyed at the cape. Our numerical results further clarified that these damages are well explained by the calculated hydraulic force of tsunamis. This kind of analysis that integrated the observation and numerical results is important to evaluate environmental and human damages quantitatively, and to make a future disaster prevention plan.

Transport properties of damaged materials. Cementitious barriers partnership

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langton, C.

2014-11-01

The objective of the Cementitious Barriers Partnership (CBP) project is to develop tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers used in low-level waste storage applications. One key concern for the long-term durability of concrete is the degradation of the cementitious matrix, which occurs as a result of aggressive chemical species entering the material or leaching out in the environment, depending on the exposure conditions. The objective of the experimental study described in this report is to provide experimental data relating damage in cementitious materials to changes in transport properties, whichmore » can eventually be used to support predictive model development. In order to get results within a reasonable timeframe and to induce as much as possible uniform damage level in materials, concrete samples were exposed to freezing and thawing (F/T) cycles. The methodology consisted in exposing samples to F/T cycles and monitoring damage level with ultrasonic pulse velocity measurements. Upon reaching pre-selected damage levels, samples were tested to evaluate changes in transport properties. Material selection for the study was motivated by the need to get results rapidly, in order to assess the relevance of the methodology. Consequently, samples already available at SIMCO from past studies were used. They consisted in three different concrete mixtures cured for five years in wet conditions. The mixtures had water-to-cement ratios of 0.5, 0.65 and 0.75 and were prepared with ASTM Type I cement only. The results showed that porosity is not a good indicator for damage caused by the formation of microcracks. Some materials exhibited little variations in porosity even for high damage levels. On the other hand, significant variations in tortuosity were measured in all materials. This implies that damage caused by internal pressure does not necessarily create additional pore space in the microstructure, but likely creates new thin pathways between existing pore space for species to travel. These results have a significant impact on modeling efforts. Models relating porosity to tortuosity and permeability are unlikely to provide the correct basis for predicting long-term durability of concrete sustaining internal pressures and microcrack formation. Other avenues like the modeling of internal crystallization pressure need to be explored.« less

On the occurrence of rainstorm damage based on home insurance and weather data

NASA Astrophysics Data System (ADS)

Spekkers, M. H.; Clemens, F. H. L. R.; ten Veldhuis, J. A. E.

2014-08-01

Rainstorm damage caused by malfunctioning of urban drainage systems and water intrusion due to defects in the building envelope can be considerable. Little research on this topic focused on the collection of damage data, the understanding of damage mechanisms and the deepening of data analysis methods. In this paper, the relative contribution of different failure mechanisms to the occurrence of rainstorm damage are investigated, as well as the extent to which these mechanisms relate to weather variables. For a case study in Rotterdam, the Netherlands, a property level home insurance database of around 3100 water-related damage claims was analysed. Records include comprehensive transcripts of communication between insurer, insured and damage assessment experts, which allowed claims to be classified according to their actual damage cause. Results show that roof and wall leakage is the most frequent failure mechanism causing precipitation-related claims, followed by blocked roof gutters, melting snow and sewer flooding. Claims related to sewer flooding were less present in the data, but are associated with significantly larger claim sizes than claims in the majority class, i.e. roof and wall leakages. Rare events logistic regression analysis revealed that maximum rainfall intensity and rainfall volume are significant predictors for the occurrence probability of precipitation-related claims. Moreover, it was found that claims associated with rainfall intensities smaller than 7-8 mm in a 60 min window are mainly related to failures processes in the private domain, such as roof and wall leakages. For rainfall events that exceed the 7-8 mm h-1 threshold, failure of systems in the public domain, such as sewer systems, start to contribute considerably to the overall occurrence probability of claims. The communication transcripts, however, lacked information to be conclusive about to extent to which sewer-related claims were caused by overloading of sewer systems or failure of system components.

On the occurrence of rainstorm damage based on home insurance and weather data

NASA Astrophysics Data System (ADS)

Spekkers, M. H.; Clemens, F. H. L. R.; ten Veldhuis, J. A. E.

2015-02-01

Rainstorm damage caused by the malfunction of urban drainage systems and water intrusion due to defects in the building envelope can be considerable. Little research on this topic focused on the collection of damage data, the understanding of damage mechanisms and the deepening of data analysis methods. In this paper, the relative contribution of different failure mechanisms to the occurrence of rainstorm damage is investigated, as well as the extent to which these mechanisms relate to weather variables. For a case study in Rotterdam, the Netherlands, a property level home insurance database of around 3100 water-related damage claims was analysed. The records include comprehensive transcripts of communication between insurer, insured and damage assessment experts, which allowed claims to be classified according to their actual damage cause. The results show that roof and wall leakage is the most frequent failure mechanism causing precipitation-related claims, followed by blocked roof gutters, melting snow and sewer flooding. Claims related to sewer flooding were less present in the data, but are associated with significantly larger claim sizes than claims in the majority class, i.e. roof and wall leakages. Rare events logistic regression analysis revealed that maximum rainfall intensity and rainfall volume are significant predictors for the occurrence probability of precipitation-related claims. Moreover, it was found that claims associated with rainfall intensities smaller than 7-8 mm in a 60-min window are mainly related to failure processes in the private domain, such as roof and wall leakages. For rainfall events that exceed the 7-8 mm h-1 threshold, the failure of systems in the public domain, such as sewer systems, start to contribute considerably to the overall occurrence probability of claims. The communication transcripts, however, lacked information to be conclusive about to which extent sewer-related claims were caused by overloading of sewer systems or failure of system components.

Summary of the Effects of Two Years of Hygro-Thermal Cycling on a Carbon/Epoxy Composite Material

NASA Technical Reports Server (NTRS)

Kohlman, Lee W.; Binienda, Wieslaw K.; Roberts, Gary D.; Miller, Sandi G.; Pereira, J. Michael; Bail, Justin L.

2011-01-01

Composite materials are beginning to be used for structures in the fan section of commercial gas turbine engines. This paper explores the type of damage that could occur within one type of composite material after exposure to hygrothermal cycles (temperature/humidity cycles) that are representative of the environment in the fan section of an engine. The effect of this damage on composite material properties is measured. Chemical changes in the matrix material were limited to the exposed surface. Microcrack formation was identified in the composite material. This damage did not cause a significant reduction in tensile strength or impact penetration resistance of the composite material. Additional data is needed to assess the effect of damage on compressive strength.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarwar, Tarique; Zafaryab, Md; Husain, Mohammed Amir

Ferulic acid (FA) is a plant polyphenol showing diverse therapeutic effects against cancer, diabetes, cardiovascular and neurodegenerative diseases. FA is a known antioxidant at lower concentrations, however at higher concentrations or in the presence of metal ions such as copper, it may act as a pro-oxidant. It has been reported that copper levels are significantly raised in different malignancies. Cancer cells are under increased oxidative stress as compared to normal cells. Certain therapeutic substances like polyphenols can further increase this oxidative stress and kill cancer cells without affecting the proliferation of normal cells. Through various in vitro experiments we havemore » shown that the pro-oxidant properties of FA are enhanced in the presence of copper. Comet assay demonstrated the ability of FA to cause oxidative DNA breakage in human peripheral lymphocytes which was ameliorated by specific copper-chelating agent such as neocuproine and scavengers of ROS. This suggested the mobilization of endogenous copper in ROS generation and consequent DNA damage. These results were further validated through cytotoxicity experiments involving different cell lines. Thus, we conclude that such a pro-oxidant mechanism involving endogenous copper better explains the anticancer activities of FA. This would be an alternate non-enzymatic, and copper-mediated pathway for the cytotoxic activities of FA where it can selectively target cancer cells with elevated levels of copper and ROS. - Highlights: • Pro-oxidant properties of ferulic acid are enhanced in presence of copper. • Ferulic acid causes oxidative DNA damage in lymphocytes as observed by comet assay. • DNA damage was ameliorated by copper chelating agent neocuproine and ROS scavengers. • Endogenous copper is involved in ROS generation causing DNA damage. • Ferulic acid exerts cancer cell specific cytotoxicity as observed by MTT assay.« less

All-season flash flood forecasting system for real-time operations

USDA-ARS?s Scientific Manuscript database

Flash floods can cause extensive damage to both life and property, especially because they are difficult to predict. Flash flood prediction requires high-resolution meteorologic observations and predictions, as well as calibrated hydrologic models in addition to extensive data handling. We have de...

Effects of realistic heat straightening repair on the properties and serviceability of damaged steel beam bridges.

DOT National Transportation Integrated Search

2012-02-01

The permanent deformations in steel beam bridges caused by collision with high profile vehicles can be repaired by heat straightening, : which is a structurally efficient and costeffective repair process developed by many engineers over the years....

Summary of floods in the United States during 1960

USGS Publications Warehouse

Rostvedt, J.O.

1965-01-01

This report describes the most outstanding floods in the United States during 1960. No major floods occurred during the year, although two floods caused severe damage the first in March and April in eastern Nebraska and adjacent areas, and the second in September in Puerto Rico.Unseasonal rains in mid-March caused extensive flooding in north-central Florida. Several thousand persons were evacuated from their homes, and damage to homes, roads, and crops was extensive.The most widespread flooding ever known in Nebraska occurred late in March and early in April as a result of rapid melting of a heavy snow cover. Most of the flood damage, estimated at about $3 million, was to roads and bridges. The flood area extended into South Dakota, Iowa, Kansas, Missouri, and Wisconsin.Snowmelt in April supplemented by rains and later heavy rains in early May caused severe flooding in northern Wisconsin and in Michigan Upper Peninsula.The most destructive flood of the year was in eastern Puerto Rico as the result of hurricane Donna. More than one hundred persons died, and considerably more than one hundred persons were injured; property damage was f.bout $7 million. Hurricane Donna also caused severe flooding as it passed over Florida and along the Atlantic coastline.In addition to these floods mentioned, 31 others of lesser magnitude were significant enough to report in this annual summary.

Examining the impact of lahars on buildings using numerical modelling

NASA Astrophysics Data System (ADS)

Mead, Stuart R.; Magill, Christina; Lemiale, Vincent; Thouret, Jean-Claude; Prakash, Mahesh

2017-05-01

Lahars are volcanic flows containing a mixture of fluid and sediment which have the potential to cause significant damage to buildings, critical infrastructure and human life. The extent of this damage is controlled by properties of the lahar, location of elements at risk and susceptibility of these elements to the lahar. Here we focus on understanding lahar-induced building damage. Quantification of building damage can be difficult due to the complexity of lahar behaviour (hazard), varying number and type of buildings exposed to the lahar (exposure) and the uncertain susceptibility of buildings to lahar impacts (vulnerability). In this paper, we quantify and examine the importance of lahar hazard, exposure and vulnerability in determining building damage with reference to a case study in the city of Arequipa, Peru. Numerical modelling is used to investigate lahar properties that are important in determining the inundation area and forces applied to buildings. Building vulnerability is quantified through the development of critical depth-pressure curves based on the ultimate bending moment of masonry structures. In the case study area, results suggest that building strength plays a minor role in determining overall building losses in comparison to the effects of building exposure and hydraulic characteristics of the lahar.

Examining the causes of a devastating debris flow

NASA Astrophysics Data System (ADS)

Balcerak, Ernie

2014-08-01

Storm-triggered landslides cause loss of life, property damage, and landscape alterations. For instance, the remnants of Hurricane Camille in 1969 caused 109 deaths in central Virginia, after 600 millimeters of rain fell in mountainous terrain in 6 hours. More recently, on 8 August 2010, a rainstorm-induced landslide devastated the Chinese county of Zhouqu, causing more than 1000 deaths. A new modeling study by Ren examines the multiple factors, natural and human caused, that came together to produce this event. Three things contribute to storm-triggered landslides: geological condition, surface loading and vegetation roots, and extreme precipitation.

In vitro study of the mechanical effects of shock-wave lithotripsy.

PubMed

Howard, D; Sturtevant, B

1997-01-01

Impulsive stress in repeated shock waves administered during extracorporeal shock-wave lithotripsy (ESWL) causes injury to kidney tissue. In a study of the mechanical input of ESWL, the effects of focused shock waves on thin planar polymeric membranes immersed in a variety of tissue-mimicking fluids have been examined. A direct mechanism of failure by shock compression and an indirect mechanism by bubble collapse have been observed. Thin membranes are easily damaged by bubble collapse. After propagating through cavitation-free acoustically heterogeneous media (liquids mixed with hollow glass spheres, and tissue) shock waves cause membranes to fail in fatigue by a shearing mechanism. As is characteristic of dynamic fatigue, the failure stress increases with strain rate, determined by the amplitude and rise time of the attenuated shock wave. Shocks with large amplitude and short rise time (i.e., in uniform media) cause no damage. Thus the inhomogeneity of tissue is likely to contribute to injury in ESWL. A definition of dose is proposed which yields a criterion for damage based on measurable shock wave properties.

Human activity and damaging landslides and floods on Madeira Island

NASA Astrophysics Data System (ADS)

Baioni, D.

2011-11-01

Over the last few decades, the island of Madeira has become an important offshore tourism and business center, with rapid economic and demographic development that has caused changes to the landscape due to human activity. In Madeira's recent history, there has been an increase over time in the frequency of occurrence of damaging landslide and flood events. As a result, the costs of restoration work due to damage caused by landslide and flood events have become a larger and larger component of Madeira's annual budget. Landslides and floods in Madeira deserve particular attention because they represent the most serious hazard to human life, to property, and to the natural environment and its important heritage value. The work reported on in this paper involved the analysis of historical data regarding damaging landslide and flood events on Madeira (in particular from 1941 to 1991) together with data on geological characteristics, topographic features, and climate, and from field observations. This analysis showed that the main factor triggering the occurrence of damaging landslide and flood events is rainfall, but that the increase in the number of damaging events recorded on Madeira Island, especially in recent times, seems to be related mostly to human activity, specifically to economic development and population growth, rather than to natural factors.

Lead Adsorption into Activated Carbon: A Critical Review of the Literature

EPA Science Inventory

Lead has been widely used in many industries due to its desirable chemical and physical properties such as its malleability and resistance to corrosion. However, Lead poisoning is a serious health hazard that causes severe damage to multiple target organs including kidney, liver,...

Damage assessment of composite plate structures with material and measurement uncertainty

NASA Astrophysics Data System (ADS)

Chandrashekhar, M.; Ganguli, Ranjan

2016-06-01

Composite materials are very useful in structural engineering particularly in weight sensitive applications. Two different test models of the same structure made from composite materials can display very different dynamic behavior due to large uncertainties associated with composite material properties. Also, composite structures can suffer from pre-existing imperfections like delaminations, voids or cracks during fabrication. In this paper, we show that modeling and material uncertainties in composite structures can cause considerable problem in damage assessment. A recently developed C0 shear deformable locking free refined composite plate element is employed in the numerical simulations to alleviate modeling uncertainty. A qualitative estimate of the impact of modeling uncertainty on the damage detection problem is made. A robust Fuzzy Logic System (FLS) with sliding window defuzzifier is used for delamination damage detection in composite plate type structures. The FLS is designed using variations in modal frequencies due to randomness in material properties. Probabilistic analysis is performed using Monte Carlo Simulation (MCS) on a composite plate finite element model. It is demonstrated that the FLS shows excellent robustness in delamination detection at very high levels of randomness in input data.

Is Allelopathic Activity of Ipomoea murucoides Induced by Xylophage Damage?

PubMed

Flores-Palacios, Alejandro; Corona-López, Angélica María; Rios, María Yolanda; Aguilar-Guadarrama, Berenice; Toledo-Hernández, Víctor Hugo; Rodríguez-López, Verónica; Valencia-Díaz, Susana

2015-01-01

Herbivory activates the synthesis of allelochemicals that can mediate plant-plant interactions. There is an inverse relationship between the activity of xylophages and the abundance of epiphytes on Ipomoea murucoides. Xylophagy may modify the branch chemical constitution, which also affects the liberation of allelochemicals with defense and allelopathic properties. We evaluated the bark chemical content and the effect of extracts from branches subjected to treatments of exclusion, mechanical damage and the presence/absence of epiphytes, on the seed germination of the epiphyte Tillandsia recurvata. Principal component analysis showed that branches without any treatment separate from branches subjected to treatments; damaged and excluded branches had similar chemical content but we found no evidence to relate intentional damage with allelopathy; however 1-hexadecanol, a defense volatile compound correlated positively with principal component (PC) 1. The chemical constitution of branches subject to exclusion plus damage or plus epiphytes was similar among them. PC2 indicated that palmitic acid (allelopathic compound) and squalene, a triterpene that attracts herbivore enemies, correlated positively with the inhibition of seed germination of T. recurvata. Inhibition of seed germination of T. recurvata was mainly correlated with the increment of palmitic acid and this compound reached higher concentrations in excluded branches treatments. Then, it is likely that the allelopathic response of I. murucoides would increase to the damage (shade, load) that may be caused by a high load of epiphytes than to damage caused by the xylophages.

Effet de l'usinage sur les proprietes mecaniques en tension et controle non-destructif des materiaux composites

NASA Astrophysics Data System (ADS)

Genereux, Louis-Alexandre

The main goal of this work is to evaluate the impact of milling operations on the integrity of unidirectional carbon/epoxy laminate. Milling, often used for finishing composite structures, cause some damage in the form of craters, cracks and thermal damage to the matrix. Here, two approaches are used to qualify and quantify the amount of damage. First, two nondestructive testing methods, namely immersion ultrasonic inspection and pulsed thermography, are evaluated on samples with artificial defects. These techniques are then used on machined samples with realistic machining damages. Only ultrasounds allowed the detection and quantification of the machining damages, but only if the damages are at the surface of the laminate. The depth of damage depends primarily on the fiber orientation of the first ply with respect to the cutting direction. The ultrasonic inspections are also accompanied by scanning electron microscope observations. The second approach is to check whether the presence of the machining damage will affect the mechanical properties of the laminate. To do this, static tensile tests are performed on samples prepared by three different methods, namely, by abrasive diamond saw, by saw cut followed by sanding and finally by milling. The results show that the damages caused by the milling operation are not important enough to affect the ultimate stress and elastic modulus. Despite this, it would be interesting, for future works, to investigate this aspect in fatigue rather than with static tests. The presence of damages on the edge might promote delamination during cyclic loads.

Data fusion of multi-scale representations for structural damage detection

NASA Astrophysics Data System (ADS)

Guo, Tian; Xu, Zili

2018-01-01

Despite extensive researches into structural health monitoring (SHM) in the past decades, there are few methods that can detect multiple slight damage in noisy environments. Here, we introduce a new hybrid method that utilizes multi-scale space theory and data fusion approach for multiple damage detection in beams and plates. A cascade filtering approach provides multi-scale space for noisy mode shapes and filters the fluctuations caused by measurement noise. In multi-scale space, a series of amplification and data fusion algorithms are utilized to search the damage features across all possible scales. We verify the effectiveness of the method by numerical simulation using damaged beams and plates with various types of boundary conditions. Monte Carlo simulations are conducted to illustrate the effectiveness and noise immunity of the proposed method. The applicability is further validated via laboratory cases studies focusing on different damage scenarios. Both results demonstrate that the proposed method has a superior noise tolerant ability, as well as damage sensitivity, without knowing material properties or boundary conditions.

Stress and Damage in Polymer Matrix Composite Materials Due to Material Degradation at High Temperatures

NASA Technical Reports Server (NTRS)

McManus, Hugh L.; Chamis, Christos C.

1996-01-01

This report describes analytical methods for calculating stresses and damage caused by degradation of the matrix constituent in polymer matrix composite materials. Laminate geometry, material properties, and matrix degradation states are specified as functions of position and time. Matrix shrinkage and property changes are modeled as functions of the degradation states. The model is incorporated into an existing composite mechanics computer code. Stresses, strains, and deformations at the laminate, ply, and micro levels are calculated, and from these calculations it is determined if there is failure of any kind. The rationale for the model (based on published experimental work) is presented, its integration into the laminate analysis code is outlined, and example results are given, with comparisons to existing material and structural data. The mechanisms behind the changes in properties and in surface cracking during long-term aging of polyimide matrix composites are clarified. High-temperature-material test methods are also evaluated.

Flame Spread and Damaged Properties of RCD Cases by Tracking

NASA Astrophysics Data System (ADS)

Choi, Chung-Seog; Kim, Hyang-Kon; Shong, Kil-Mok; Kim, Dong-Woo

In this paper, the flame spread and damaged properties of residual current protective devices (RCDs) by tracking were analyzed. Pictures of tracking process were taken by High Speed Imaging System (HSIS), and fire progression was observed by timeframe. During the tracking process of RCD, it seemed to explode just once in appearance, but in the results of HSIS analysis, a small fire broke out and disappeared repeatedly 35 times and a flash of light repeated 15 times. Finally, an explosion with a flash of light occurred and lots of particles were scattered. Electric muffle furnace was used for heat treatment of RCD cases. The surface characteristics of specimens due to heat treatment and tracking deterioration were taken by Scanning Electron Microscope (SEM). Chemical and thermal properties of these deteriorated specimens were analyzed by Fourier Transform Infrared Spectrometer (FT-IR) and Differential Thermal Analyzer (DTA). The carbonization characteristics showed different chemical properties due to energy sources, and the results could be applicable to judge the accident causes.

78 FR 21590 - Coconino National Forest; Arizona; Flagstaff Watershed Protection Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... also cause extensive damage to private municipal property should a high-intensity wildfire occur in... would be necessarily to implement the proposed activities. Treatments would include mechanical and hand thinning as well as prescribed fire on approximately 8,810 acres. Mechanical tree thinning would occur...

32 CFR 842.55 - Scope of this subpart.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Scope of this subpart. 842.55 Section 842.55 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION... property damage, personal injury, or death caused by military and civilian members of the US Armed Forces...

32 CFR 842.137 - Scope of this subpart.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Scope of this subpart. 842.137 Section 842.137 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION... United States for damage to US Government property caused by CAP members or third parties. ...

25 CFR 11.1005 - Preliminary inquiry.

Code of Federal Regulations, 2010 CFR

2010-04-01

... that the minor will commit a serious act causing damage to person or property. (g) The children's court... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

25 CFR 11.1005 - Preliminary inquiry.

Code of Federal Regulations, 2011 CFR

2011-04-01

... that the minor will commit a serious act causing damage to person or property. (g) The children's court... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

25 CFR 11.1005 - Preliminary inquiry.

Code of Federal Regulations, 2013 CFR

2013-04-01

... that the minor will commit a serious act causing damage to person or property. (g) The children's court... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

25 CFR 11.1005 - Preliminary inquiry.

Code of Federal Regulations, 2012 CFR

2012-04-01

... that the minor will commit a serious act causing damage to person or property. (g) The children's court... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

25 CFR 11.1005 - Preliminary inquiry.

Code of Federal Regulations, 2014 CFR

2014-04-01

... that the minor will commit a serious act causing damage to person or property. (g) The children's court... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

45 CFR 34.5 - Unallowable claims.

Code of Federal Regulations, 2014 CFR

2014-10-01

... or damage caused in whole or in part by the negligent or wrongful act of the claimant or his agent or... exercise due care in protecting his or her property. (10) Sales Tax. Reimbursements for the payment of sales tax incurred in connection with repairs or replacing an item will not be allowed. ...

45 CFR 34.5 - Unallowable claims.

Code of Federal Regulations, 2010 CFR

2010-10-01

... or damage caused in whole or in part by the negligent or wrongful act of the claimant or his agent or... exercise due care in protecting his or her property. (10) Sales Tax. Reimbursements for the payment of sales tax incurred in connection with repairs or replacing an item will not be allowed. ...

45 CFR 34.5 - Unallowable claims.

Code of Federal Regulations, 2013 CFR

2013-10-01

... or damage caused in whole or in part by the negligent or wrongful act of the claimant or his agent or... exercise due care in protecting his or her property. (10) Sales Tax. Reimbursements for the payment of sales tax incurred in connection with repairs or replacing an item will not be allowed. ...

45 CFR 34.5 - Unallowable claims.

Code of Federal Regulations, 2011 CFR

2011-10-01

... or damage caused in whole or in part by the negligent or wrongful act of the claimant or his agent or... exercise due care in protecting his or her property. (10) Sales Tax. Reimbursements for the payment of sales tax incurred in connection with repairs or replacing an item will not be allowed. ...

30 CFR 250.490 - Hydrogen sulfide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... mitigate damage to property and the environment caused by H2S. You must follow the requirements of this... documentation do I need? For each individual working on the platform, either: (i) You must have documentation of... respirator; practice in donning and adjusting the assigned respirator; information on the safe briefing areas...

Damage and fracture in fabric-reinforced composites under quasi-static and dynamic bending

NASA Astrophysics Data System (ADS)

Ullah, H.; Harland, A. R.; Silberschmidt, V. V.

2013-07-01

Fabric-reinforced polymer composites used in sports products can be exposed to different in-service conditions such as large deformations caused by quasi-static and dynamic loading. Composite materials subjected to such bending loads can demonstrate various damage modes - matrix cracking, delamination and, ultimately, fabric fracture. Damage evolution in composites affects both their in-service properties and performance that can deteriorate with time. Such behaviour needs adequate means of analysis and investigation, the main approaches being experimental characterisation and non-destructive examination of internal damage in composite laminates. This research deals with a deformation behaviour and damage in carbon fabric-reinforced polymer (CFRP) laminates caused by quasi-static and dynamic bending. Experimental tests were carried out to characterise the behaviour of a CFRP material under large-deflection bending, first in quasi-static and then in dynamic conditions. Izod-type impact bending tests were performed on un-notched specimens of CFRP using a Resil impactor to assess the transient response and energy absorbing capability of the material. X-ray micro computed tomography (micro-CT) was used to analyse various damage modes in the tested specimens. X-ray tomographs revealed that through-thickness matrix cracking, inter-ply and intra-ply delamination such as tow debonding, and fabric fracture were the prominent damage modes both in quasi-static and dynamic test specimens. However, the inter-ply damage was localised at impact location in dynamically tested specimens, whereas in the quasi-static specimens, it spread almost over the entire interface.

Winter storm intensity, hazards, and property losses in the New York tristate area.

PubMed

Shimkus, Cari E; Ting, Mingfang; Booth, James F; Adamo, Susana B; Madajewicz, Malgosia; Kushnir, Yochanan; Rieder, Harald E

2017-07-01

Winter storms pose numerous hazards to the Northeast United States, including rain, snow, strong wind, and flooding. These hazards can cause millions of dollars in damages from one storm alone. This study investigates meteorological intensity and impacts of winter storms from 2001 to 2014 on coastal counties in Connecticut, New Jersey, and New York and underscores the consequences of winter storms. The study selected 70 winter storms on the basis of station observations of surface wind strength, heavy precipitation, high storm tide, and snow extremes. Storm rankings differed between measures, suggesting that intensity is not easily defined with a single metric. Several storms fell into two or more categories (multiple-category storms). Following storm selection, property damages were examined to determine which types lead to high losses. The analysis of hazards (or events) and associated damages using the Storm Events Database of the National Centers for Environmental Information indicates that multiple-category storms were responsible for a greater portion of the damage. Flooding was responsible for the highest losses, but no discernible connection exists between the number of storms that afflict a county and the damage it faces. These results imply that losses may rely more on the incidence of specific hazards, infrastructure types, and property values, which vary throughout the region. © 2017 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.

Economic Estimation of the Losses Caused by Surface Water Pollution Accidents in China From the Perspective of Water Bodies’ Functions

PubMed Central

Yao, Hong; You, Zhen; Liu, Bo

2016-01-01

The number of surface water pollution accidents (abbreviated as SWPAs) has increased substantially in China in recent years. Estimation of economic losses due to SWPAs has been one of the focuses in China and is mentioned many times in the Environmental Protection Law of China promulgated in 2014. From the perspective of water bodies’ functions, pollution accident damages can be divided into eight types: damage to human health, water supply suspension, fishery, recreational functions, biological diversity, environmental property loss, the accident’s origin and other indirect losses. In the valuation of damage to people’s life, the procedure for compensation of traffic accidents in China was used. The functional replacement cost method was used in economic estimation of the losses due to water supply suspension and loss of water’s recreational functions. Damage to biological diversity was estimated by recovery cost analysis and damage to environmental property losses were calculated using pollutant removal costs. As a case study, using the proposed calculation procedure the economic losses caused by the major Songhuajiang River pollution accident that happened in China in 2005 have been estimated at 2263 billion CNY. The estimated economic losses for real accidents can sometimes be influenced by social and political factors, such as data authenticity and accuracy. Besides, one or more aspects in the method might be overestimated, underrated or even ignored. The proposed procedure may be used by decision makers for the economic estimation of losses in SWPAs. Estimates of the economic losses of pollution accidents could help quantify potential costs associated with increased risk sources along lakes/rivers but more importantly, highlight the value of clean water to society as a whole. PMID:26805869

Economic Estimation of the Losses Caused by Surface Water Pollution Accidents in China From the Perspective of Water Bodies' Functions.

PubMed

Yao, Hong; You, Zhen; Liu, Bo

2016-01-22

The number of surface water pollution accidents (abbreviated as SWPAs) has increased substantially in China in recent years. Estimation of economic losses due to SWPAs has been one of the focuses in China and is mentioned many times in the Environmental Protection Law of China promulgated in 2014. From the perspective of water bodies' functions, pollution accident damages can be divided into eight types: damage to human health, water supply suspension, fishery, recreational functions, biological diversity, environmental property loss, the accident's origin and other indirect losses. In the valuation of damage to people's life, the procedure for compensation of traffic accidents in China was used. The functional replacement cost method was used in economic estimation of the losses due to water supply suspension and loss of water's recreational functions. Damage to biological diversity was estimated by recovery cost analysis and damage to environmental property losses were calculated using pollutant removal costs. As a case study, using the proposed calculation procedure the economic losses caused by the major Songhuajiang River pollution accident that happened in China in 2005 have been estimated at 2263 billion CNY. The estimated economic losses for real accidents can sometimes be influenced by social and political factors, such as data authenticity and accuracy. Besides, one or more aspects in the method might be overestimated, underrated or even ignored. The proposed procedure may be used by decision makers for the economic estimation of losses in SWPAs. Estimates of the economic losses of pollution accidents could help quantify potential costs associated with increased risk sources along lakes/rivers but more importantly, highlight the value of clean water to society as a whole.

Damage tolerance in filament-wound graphite/epoxy pressure vessels

NASA Technical Reports Server (NTRS)

Simon, William E.; Ngueyen, Vinh D.; Chenna, Ravi K.

1995-01-01

Graphite/epoxy composites are extensively used in the aerospace and sporting goods industries due to their superior engineering properties compared to those of metals. However, graphite/epoxy is extremely susceptible to impact damage which can cause considerable and sometimes undetected reduction in strength. An inelastic impact model was developed to predict damage due to low-velocity impact. A transient dynamic finite element formulation was used in conjunction with the 3D Tsai-Wu failure criterion to determine and incorporate failure in the materials during impact. Material degradation can be adjusted from no degradation to partial degradation to full degradation. The developed software is based on an object-oriented implementation framework called Extensible Implementation Framework for Finite Elements (EIFFE).

Rock Failure Analysis Based on a Coupled Elastoplastic-Logarithmic Damage Model

NASA Astrophysics Data System (ADS)

Abdia, M.; Molladavoodi, H.; Salarirad, H.

2017-12-01

The rock materials surrounding the underground excavations typically demonstrate nonlinear mechanical response and irreversible behavior in particular under high in-situ stress states. The dominant causes of irreversible behavior are plastic flow and damage process. The plastic flow is controlled by the presence of local shear stresses which cause the frictional sliding. During this process, the net number of bonds remains unchanged practically. The overall macroscopic consequence of plastic flow is that the elastic properties (e.g. the stiffness of the material) are insensitive to this type of irreversible change. The main cause of irreversible changes in quasi-brittle materials such as rock is the damage process occurring within the material. From a microscopic viewpoint, damage initiates with the nucleation and growth of microcracks. When the microcracks length reaches a critical value, the coalescence of them occurs and finally, the localized meso-cracks appear. The macroscopic and phenomenological consequence of damage process is stiffness degradation, dilatation and softening response. In this paper, a coupled elastoplastic-logarithmic damage model was used to simulate the irreversible deformations and stiffness degradation of rock materials under loading. In this model, damage evolution & plastic flow rules were formulated in the framework of irreversible thermodynamics principles. To take into account the stiffness degradation and softening on post-peak region, logarithmic damage variable was implemented. Also, a plastic model with Drucker-Prager yield function was used to model plastic strains. Then, an algorithm was proposed to calculate the numerical steps based on the proposed coupled plastic and damage constitutive model. The developed model has been programmed in VC++ environment. Then, it was used as a separate and new constitutive model in DEM code (UDEC). Finally, the experimental Oolitic limestone rock behavior was simulated based on the developed model. The irreversible strains, softening and stiffness degradation were reproduced in the numerical results. Furthermore, the confinement pressure dependency of rock behavior was simulated in according to experimental observations.

Honest sexual signalling mediated by parasite and testosterone effects on oxidative balance.

PubMed

Mougeot, Francois; Martínez-Padilla, Jesús; Webster, Lucy M I; Blount, Jonathan D; Pérez-Rodríguez, Lorenzo; Piertney, Stuart B

2009-03-22

Extravagant ornaments evolved to advertise their bearers' quality, the honesty of the signal being ensured by the cost paid to produce or maintain it. The oxidation handicap hypothesis (OHH) proposes that a main cost of testosterone-dependent ornamentation is oxidative stress, a condition whereby the production of reactive oxygen and nitrogen species (ROS/RNS) overwhelms the capacity of antioxidant defences. ROS/RNS are unstable, very reactive by-products of normal metabolic processes that can cause extensive damage to key biomolecules (cellular proteins, lipids and DNA). Oxidative stress has been implicated in the aetiology of many diseases and could link ornamentation and genetic variation in fitness-related traits. We tested the OHH in a free-living bird, the red grouse. We show that elevated testosterone enhanced ornamentation and increased circulating antioxidant levels, but caused oxidative damage. Males with smaller ornaments suffered more oxidative damage than those with larger ornaments when forced to increase testosterone levels, consistent with a handicap mechanism. Parasites depleted antioxidant defences, caused oxidative damage and reduced ornament expression. Oxidative damage extent and the ability of males to increase antioxidant defences also explained the impacts of testosterone and parasites on ornamentation within treatment groups. Because oxidative stress is intimately linked to immune function, parasite resistance and fitness, it provides a reliable currency in the trade-off between individual health and ornamentation. The costs induced by oxidative stress can apply to a wide range of signals, which are testosterone-dependent or coloured by pigments with antioxidant properties.

Honest sexual signalling mediated by parasite and testosterone effects on oxidative balance

PubMed Central

Mougeot, Francois; Martínez-Padilla, Jesu´s; Webster, Lucy M.I.; Blount, Jonathan D.; Pérez-Rodríguez, Lorenzo; Piertney, Stuart B.

2008-01-01

Extravagant ornaments evolved to advertise their bearers' quality, the honesty of the signal being ensured by the cost paid to produce or maintain it. The oxidation handicap hypothesis (OHH) proposes that a main cost of testosterone-dependent ornamentation is oxidative stress, a condition whereby the production of reactive oxygen and nitrogen species (ROS/RNS) overwhelms the capacity of antioxidant defences. ROS/RNS are unstable, very reactive by-products of normal metabolic processes that can cause extensive damage to key biomolecules (cellular proteins, lipids and DNA). Oxidative stress has been implicated in the aetiology of many diseases and could link ornamentation and genetic variation in fitness-related traits. We tested the OHH in a free-living bird, the red grouse. We show that elevated testosterone enhanced ornamentation and increased circulating antioxidant levels, but caused oxidative damage. Males with smaller ornaments suffered more oxidative damage than those with larger ornaments when forced to increase testosterone levels, consistent with a handicap mechanism. Parasites depleted antioxidant defences, caused oxidative damage and reduced ornament expression. Oxidative damage extent and the ability of males to increase antioxidant defences also explained the impacts of testosterone and parasites on ornamentation within treatment groups. Because oxidative stress is intimately linked to immune function, parasite resistance and fitness, it provides a reliable currency in the trade-off between individual health and ornamentation. The costs induced by oxidative stress can apply to a wide range of signals, which are testosterone-dependent or coloured by pigments with antioxidant properties. PMID:19129122

Detecting Damage in Composite Material Using Nonlinear Elastic Wave Spectroscopy Methods

NASA Astrophysics Data System (ADS)

Meo, Michele; Polimeno, Umberto; Zumpano, Giuseppe

2008-05-01

Modern aerospace structures make increasing use of fibre reinforced plastic composites, due to their high specific mechanical properties. However, due to their brittleness, low velocity impact can cause delaminations beneath the surface, while the surface may appear to be undamaged upon visual inspection. Such damage is called barely visible impact damage (BVID). Such internal damages lead to significant reduction in local strengths and ultimately could lead to catastrophic failures. It is therefore important to detect and monitor damages in high loaded composite components to receive an early warning for a well timed maintenance of the aircraft. Non-linear ultrasonic spectroscopy methods are promising damage detection and material characterization tools. In this paper, two different non-linear elastic wave spectroscopy (NEWS) methods are presented: single mode nonlinear resonance ultrasound (NRUS) and nonlinear wave modulation technique (NWMS). The NEWS methods were applied to detect delamination damage due to low velocity impact (<12 J) on various composite plates. The results showed that the proposed methodology appear to be highly sensitive to the presence of damage with very promising future NDT and structural health monitoring applications.

Analysis of Retrieved Hubble Space Telescope Thermal Control Materials

NASA Technical Reports Server (NTRS)

Townsend, Jacqueline A.; Hansen, Patricia A.; Dever, Joyce A.; Triolo, Jack J.

1998-01-01

The mechanical and optical properties of the thermal control materials on the Hubble Space Telescope (HST) have degraded over the nearly seven years the telescope has been in orbit. Astronaut observations and photographs from the Second Servicing Mission (SM2) revealed large cracks in the metallized Teflon FEP, the outer-layer of the multi-layer insulation (MLI), in many locations around the telescope. Also, the emissivity of the bonded metallized Teflon FEP radiator surfaces of the telescope has increased over time. Samples of the top layer of the MLI and radiator material were retrieved during SM2, and a thorough investigation into the de-radiation followed in order to determine the primary cause of the damage. Mapping of the cracks on HST and the ground testing showed that thermal cycling with deep-layer damage from electron and proton radiation are necessary to cause the observed embrittlement. Further, strong, evidence was found indicating that chain scission (reduced molecular weight) is the dominant form of damage to the metallized Teflon FEP.

Moral understanding in children with autism.

PubMed

Grant, Cathy M; Boucher, Jill; Riggs, Kevin J; Grayson, Andrew

2005-07-01

Children with autism were compared with control groups on their ability to make moral judgements. Participants were presented with pairs of vignettes in which actions were either deliberate or accidental and caused injury to a person or damage to property. Participants were asked to judge which protagonist was the naughtier and to verbally justify this judgement. Results showed that the children with autism were as likely as controls to judge culpability on the basis of motive, and to judge injury to persons as more culpable than damage to property. Children with autism also offered some appropriate verbal justifications for their judgments although most justifications were of poor quality and reiterated the story. Results are discussed in terms of theory of mind and the possible role of deficits in complex reasoning and executive functions.

Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice.

PubMed

Kadri, Yamina; Nciri, Riadh; Brahmi, Noura; Saidi, Saber; Harrath, Abdel Halim; Alwasel, Saleh; Aldahmash, Waleed; El Feki, Abdelfatteh; Allagui, Mohamed Salah

2018-05-07

Cerium chloride (CeCl 3 ) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl 3 , 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl 3 -treated mice. In addition, CeCl 3 induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl 3 -treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl 3 -induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl 3 -damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl 3 -induced damage in the brain.

Summary of floods in the United States during 1958

USGS Publications Warehouse

Hendricks, E.L.

1964-01-01

This report describes the most outstanding floods that occurred in the United States during 1958.A series of storms from January 23 to February 16 brought large amounts of precipitation to northern California and produced damaging floods, particularly in the Lower Sacramento Valley where losses totaled about \\$12 million.Major floods, notable because of the large area affected, occurred on many small streams in central and south Texas, following heavy general rains in late February. Extensive flooding occurred along the Gulf Coastal plain on the lower reaches of the major streams from the Brazos River to the Nueces River. Two lives were lost, and property damage exceeded \\$1 million.Damaging floods of April 1-7 followed one of the wettest winters in California history. Swollen streams overflowed their banks throughout the central part of the State, and discharge peaks on many streams exceeded those .of the floods of December 1955. Most severely flooded was the San Francisco Bay area. Total flood damage was estimated at \\$23 million.The storms and floods of April-May in Louisiana and adjacent States outranked all other floods in the United States during 1958 with respect to intensity of rain over a large area, number of streams having maximum discharge of record, rare occurrence of peaks, and great amount (\\$21 million) of resultant damage.Heavy rains on June 8-15 caused one of the greatest summer floods of record in central Indiana. Peak discharges were high and of rare occurrences. Failure of numerous levees along the Wabash River caused great damage. Crop damage alone was estimated at \\$48 million.Intense rains of July 1-2 caused record-breaking floods in southwestern Iowa. Rapid rises and the great magnitude of the floods on small streams resulted in 18 deaths and many injuries. Six towns and cities along the East Nishnabotna River and its tributaries were particularly hard hit; rural damage was also high. Total damage was estimated at \\$15 million.Heavy rains (as much as 40 inches during the last 2 weeks in September) from the middle of September to the middle of October caused destructive floods along the Rio Grande in Texas and Mexico. Many communities were isolated by the flood waters, and damage to crops was great.In addition to the 7 floods mentioned above, 21 others of lesser magnitude are reported in this annual summary.

HOW to Recognize Hazardous Defects in Trees

Treesearch

Minnesota Department of Natural Resources; USDA Forest Service

1996-01-01

Trees add to our enjoyment of outdoor experiences whether in forests, parks, or urban landscapes. Too often, we are unaware of the risks associated with defective trees, which can cause personal injury and property damage. Interest in hazard tree management has increased in recent years due to safety and liability concerns resulting from preventable accidents....

Development of an Analysis Tool for Evaluation of Marginal Impacts of Freeway Incidents in the Las Vegas Area Using FAST’s Dashboard Freeway Data.

DOT National Transportation Integrated Search

2014-01-21

Incidents are a major source of non-recurring congestion on freeways. In addition to costing millions of dollars in the loss of life, injuries and property damage, traffic incidents also cause additional losses due to the resulting traffic congestion...

Moral Understanding in Children with Autism

ERIC Educational Resources Information Center

Grant, Cathy M.; Boucher, Jill; Riggs, Kevin J.; Grayson, Andrew

2005-01-01

Children with autism were compared with control groups on their ability to make moral judgements. Participants were presented with pairs of vignettes in which actions were either deliberate or accidental and caused injury to a person or damage to property. Participants were asked to judge which protagonist was the naughtier and to verbally justify…

26 CFR 1.270-1 - Limitation on deductions allowable to individuals in certain cases.

Code of Federal Regulations, 2014 CFR

2014-04-01

... to drought, (v) The net operating loss deduction allowed by section 172, or the corresponding... and expenses must be directly attributable to drought conditions and not to other causes such as...)(iv) of this paragraph: (i) Losses for damages to or destruction of property as a result of drought...

26 CFR 1.270-1 - Limitation on deductions allowable to individuals in certain cases.

Code of Federal Regulations, 2011 CFR

2011-04-01

... to drought, (v) The net operating loss deduction allowed by section 172, or the corresponding... and expenses must be directly attributable to drought conditions and not to other causes such as...)(iv) of this paragraph: (i) Losses for damages to or destruction of property as a result of drought...

26 CFR 1.270-1 - Limitation on deductions allowable to individuals in certain cases.

Code of Federal Regulations, 2012 CFR

2012-04-01

... to drought, (v) The net operating loss deduction allowed by section 172, or the corresponding... and expenses must be directly attributable to drought conditions and not to other causes such as...)(iv) of this paragraph: (i) Losses for damages to or destruction of property as a result of drought...

26 CFR 1.270-1 - Limitation on deductions allowable to individuals in certain cases.

Code of Federal Regulations, 2013 CFR

2013-04-01

... to drought, (v) The net operating loss deduction allowed by section 172, or the corresponding... and expenses must be directly attributable to drought conditions and not to other causes such as...)(iv) of this paragraph: (i) Losses for damages to or destruction of property as a result of drought...

30 CFR 551.6 - Obligations and rights under a permit or a Notice.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., coastal, or human environment; (3) Cause harm or damage to any mineral resource (in areas leased or not... environmental hazards which imminently threaten life and property; or (3) Adversely affect the environment... of the area for navigation and safety purposes. (d) Any persons conducting shallow test drilling or...

30 CFR 551.6 - Obligations and rights under a permit or a Notice.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., coastal, or human environment; (3) Cause harm or damage to any mineral resource (in areas leased or not... environmental hazards which imminently threaten life and property; or (3) Adversely affect the environment... of the area for navigation and safety purposes. (d) Any persons conducting shallow test drilling or...

30 CFR 551.6 - Obligations and rights under a permit or a Notice.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., coastal, or human environment; (3) Cause harm or damage to any mineral resource (in areas leased or not... environmental hazards which imminently threaten life and property; or (3) Adversely affect the environment... of the area for navigation and safety purposes. (d) Any persons conducting shallow test drilling or...

Phase I Report for SERRI Project No. 80037: Investigation of surge and wave reduction by vegetation

USDA-ARS?s Scientific Manuscript database

Surge and waves generated by hurricanes and other severe storms can cause devastating damage of property and loss of life in coastal areas. Vegetation in wetlands, coastal fringes and stream floodplains can reduce storm surge and waves while providing ecological benefits and complementing traditiona...

3 CFR 8386 - Proclamation 8386 of May 26, 2009. National Hurricane Preparedness Week, 2009

Code of Federal Regulations, 2010 CFR

2010-01-01

... coastal and inland communities. These powerful storms can cause heavy rainfall, high winds, tornadoes, and storm surges, which can in turn bring severe flooding, power outages, damage to homes and businesses... property of those who face advancing storms. Americans can take basic steps before a hurricane arrives. The...

48 CFR 245.7309-10 - Risk of loss.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Risk of loss. 245.7309-10...-10 Risk of loss. The Contractor is responsible for reasonable care and protection of the property until the date specified for removal. All risk of loss, damage, or destruction from any cause whatsoever...

78 FR 69118 - Information Collection Activities: General; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... human, marine, and coastal environments; to ensure the public a fair and equitable return on the... ``operations in the [O]uter Continental Shelf should be conducted in a safe manner by well trained personnel... subsoil and seabed, or other occurrences which may cause damage to the environment or to property or...

75 FR 54370 - BOEMRE Information Collection Activity: 1010-0183, Information Requirements for Exploration Plans...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... development with protection of human, marine, and coastal environments; to ensure the public a fair and... conducted in a safe manner by well-trained personnel using technology, precautions, and techniques... cause damage to the environment or to property, or endanger life or health.'' To carry out these...

38 CFR 14.667 - Claims payable.

Code of Federal Regulations, 2010 CFR

2010-07-01

... incident to the employee's service and his or her possession of the property was reasonable, useful, or... States. (4) Was not caused wholly or partly by the negligent act of claimant, the claimant's agent, or employee, and that the claimant has no right to indemnification for the loss or damage from other than the...

Recovery from Large-Scale Crises: Guidelines for Crisis Teams and Administrators

ERIC Educational Resources Information Center

Communique, 2018

2018-01-01

The United States has recently experienced numerous large-scale crises that resulted in high death tolls and extensive property damage. Critical incidents such as suicide contagion, natural disasters, or mass casualty events have the potential to cause traumatic reactions and significantly affect children's sense of safety and security. School…

38 CFR 14.667 - Claims payable.

Code of Federal Regulations, 2013 CFR

2013-07-01

... incident to the employee's service and his or her possession of the property was reasonable, useful, or... States. (4) Was not caused wholly or partly by the negligent act of claimant, the claimant's agent, or employee, and that the claimant has no right to indemnification for the loss or damage from other than the...

38 CFR 14.667 - Claims payable.

Code of Federal Regulations, 2014 CFR

2014-07-01

... incident to the employee's service and his or her possession of the property was reasonable, useful, or... States. (4) Was not caused wholly or partly by the negligent act of claimant, the claimant's agent, or employee, and that the claimant has no right to indemnification for the loss or damage from other than the...

38 CFR 14.667 - Claims payable.

Code of Federal Regulations, 2012 CFR

2012-07-01

... incident to the employee's service and his or her possession of the property was reasonable, useful, or... States. (4) Was not caused wholly or partly by the negligent act of claimant, the claimant's agent, or employee, and that the claimant has no right to indemnification for the loss or damage from other than the...

38 CFR 14.667 - Claims payable.

Code of Federal Regulations, 2011 CFR

2011-07-01

... incident to the employee's service and his or her possession of the property was reasonable, useful, or... States. (4) Was not caused wholly or partly by the negligent act of claimant, the claimant's agent, or employee, and that the claimant has no right to indemnification for the loss or damage from other than the...

Responses to Childhood Trauma: An International Perspective

ERIC Educational Resources Information Center

Little, Steven G.; Akin-Little, Angeleque

2011-01-01

Children throughout the world are exposed to traumatic events such as sexual or physical abuse, severe accidents, cancer or other life threatening illness, natural or man-made disasters, war, terrorism, the sudden death of a parent or close friend or relative, among other things. Recently, natural disasters have caused property damage and loss of…

[Effects of riboxin, essentiale, and phylloquinone on the immunomodulating and antioxidant effect of laser and magneto-laser irradiation in liver toxicosis induced by gentamycin].

PubMed

Konoplia, N A; Prokopenko, L G; Uteshev, B S

2002-01-01

The introduction of gentamycine to Wistar rats leads to the toxic liver damage, suppresses humoral immune response to goat erythrocytes, and induces immunosuppressant properties in erythrocytes (caused by increased lipid peroxidation in their membranes and violated cell energy balance) Under these conditions, a combination of the laser or magneto-laser irradiation with the administration of phylloquinone of riboxin provides for a more effective correction of the immune reaction and antioxidant status as compared to the radiation treatment without drugs or with essential. Elimination of the gentamycine induced immunosuppressant properties of erythrocytes is explained by the ability of phylloquinone and essential to reduce the intensity of lipid peroxidation in the cell membranes and with the ability of riboxin to normalize the cell energy balance. An important factor of immunosuppression development in the case of a toxic liver damage caused by D-galactosamine it the interaction of thrombocytes and light erythrocytes with serum factors. The introduction of essential and riboxin favors this interaction and stimulates the development of immunosuppression in thrombocytes.

Time-resolved optical spectroscopic quantification of red blood cell damage caused by cardiovascular devices

NASA Astrophysics Data System (ADS)

Sakota, D.; Sakamoto, R.; Sobajima, H.; Yokoyama, N.; Yokoyama, Y.; Waguri, S.; Ohuchi, K.; Takatani, S.

2008-02-01

Cardiovascular devices such as heart-lung machine generate un-physiological level of shear stress to damage red blood cells, leading to hemolysis. The diagnostic techniques of cell damages, however, have not yet been established. In this study, the time-resolved optical spectroscopy was applied to quantify red blood cell (RBC) damages caused by the extracorporeal circulation system. Experimentally, the fresh porcine blood was subjected to varying degrees of shear stress in the rotary blood pump, followed with measurement of the time-resolved transmission characteristics using the pico-second pulses at 651 nm. The propagated optical energy through the blood specimen was detected using a streak camera. The data were analyzed in terms of the mean cell volume (MCV) and mean cell hemoglobin concentration (MCHC) measured separately versus the energy and propagation time of the light pulses. The results showed that as the circulation time increased, the MCV increased with decrease in MCHC. It was speculated that the older RBCs with smaller size and fragile membrane properties had been selectively destroyed by the shear stress. The time-resolved optical spectroscopy is a useful technique in quantifying the RBCs' damages by measuring the energy and propagation time of the ultra-short light pulses through the blood.

Is Allelopathic Activity of Ipomoea murucoides Induced by Xylophage Damage?

PubMed Central

Flores-Palacios, Alejandro; Corona-López, Angélica María; Rios, María Yolanda; Aguilar-Guadarrama, Berenice; Toledo-Hernández, Víctor Hugo; Rodríguez-López, Verónica; Valencia-Díaz, Susana

2015-01-01

Herbivory activates the synthesis of allelochemicals that can mediate plant-plant interactions. There is an inverse relationship between the activity of xylophages and the abundance of epiphytes on Ipomoea murucoides. Xylophagy may modify the branch chemical constitution, which also affects the liberation of allelochemicals with defense and allelopathic properties. We evaluated the bark chemical content and the effect of extracts from branches subjected to treatments of exclusion, mechanical damage and the presence/absence of epiphytes, on the seed germination of the epiphyte Tillandsia recurvata. Principal component analysis showed that branches without any treatment separate from branches subjected to treatments; damaged and excluded branches had similar chemical content but we found no evidence to relate intentional damage with allelopathy; however 1-hexadecanol, a defense volatile compound correlated positively with principal component (PC) 1. The chemical constitution of branches subject to exclusion plus damage or plus epiphytes was similar among them. PC2 indicated that palmitic acid (allelopathic compound) and squalene, a triterpene that attracts herbivore enemies, correlated positively with the inhibition of seed germination of T. recurvata. Inhibition of seed germination of T. recurvata was mainly correlated with the increment of palmitic acid and this compound reached higher concentrations in excluded branches treatments. Then, it is likely that the allelopathic response of I. murucoides would increase to the damage (shade, load) that may be caused by a high load of epiphytes than to damage caused by the xylophages. PMID:26625350

Study of cumulative fatigue damage detection for used parts with nonlinear output frequency response functions based on NARMAX modelling

NASA Astrophysics Data System (ADS)

Huang, Honglan; Mao, Hanying; Mao, Hanling; Zheng, Weixue; Huang, Zhenfeng; Li, Xinxin; Wang, Xianghong

2017-12-01

Cumulative fatigue damage detection for used parts plays a key role in the process of remanufacturing engineering and is related to the service safety of the remanufactured parts. In light of the nonlinear properties of used parts caused by cumulative fatigue damage, the based nonlinear output frequency response functions detection approach offers a breakthrough to solve this key problem. First, a modified PSO-adaptive lasso algorithm is introduced to improve the accuracy of the NARMAX model under impulse hammer excitation, and then, an effective new algorithm is derived to estimate the nonlinear output frequency response functions under rectangular pulse excitation, and a based nonlinear output frequency response functions index is introduced to detect the cumulative fatigue damage in used parts. Then, a novel damage detection approach that integrates the NARMAX model and the rectangular pulse is proposed for nonlinear output frequency response functions identification and cumulative fatigue damage detection of used parts. Finally, experimental studies of fatigued plate specimens and used connecting rod parts are conducted to verify the validity of the novel approach. The obtained results reveal that the new approach can detect cumulative fatigue damages of used parts effectively and efficiently and that the various values of the based nonlinear output frequency response functions index can be used to detect the different fatigue damages or working time. Since the proposed new approach can extract nonlinear properties of systems by only a single excitation of the inspected system, it shows great promise for use in remanufacturing engineering applications.

Development and regeneration of vestibular hair cells in mammals.

PubMed

Burns, Joseph C; Stone, Jennifer S

2017-05-01

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small organs in the inner ear. Damage to hair cells and their innervating neurons can cause crippling symptoms such as vertigo, visual field oscillation, and imbalance. In adult rodents, some Type II hair cells are regenerated and become re-innervated after damage, presenting opportunities for restoring vestibular function after hair cell damage. This article reviews features of vestibular sensory cells in mammals, including their basic properties, how they develop, and how they are replaced after damage. We discuss molecules that control vestibular hair cell regeneration and highlight areas in which our understanding of development and regeneration needs to be deepened. Copyright © 2016 Elsevier Ltd. All rights reserved.

Method to reduce damage to backing plate

DOEpatents

Perry, Michael D.; Banks, Paul S.; Stuart, Brent C.

2001-01-01

The present invention is a method for penetrating a workpiece using an ultra-short pulse laser beam without causing damage to subsequent surfaces facing the laser. Several embodiments are shown which place holes in fuel injectors without damaging the back surface of the sack in which the fuel is ejected. In one embodiment, pulses from an ultra short pulse laser remove about 10 nm to 1000 nm of material per pulse. In one embodiment, a plasma source is attached to the fuel injector and initiated by common methods such as microwave energy. In another embodiment of the invention, the sack void is filled with a solid. In one other embodiment, a high viscosity liquid is placed within the sack. In general, high-viscosity liquids preferably used in this invention should have a high damage threshold and have a diffusing property.

Analysis on Causes of Employees' Damaged Rights in Perspective of Property Rights

NASA Astrophysics Data System (ADS)

Zheng, Xiuzhi; Lin, Lijie

An employment contract is a contract of human capital property rights transaction between employees and employer. Due to its incompleteness, the employees' rights can not be fully defined in the employment contract. Therefore, some rights of employees lie in "Public Domain". Due to the rule of "Power Defining Property" in the prosperity dealing, employers with great power are able to grab at employees' rights in "Public Domain". In this paper, the theoretical foundation on the source of violations to employees' rights, the value of labor contract law and the role of labor union playing in the labor relationship are presented in perspective of property rights.

Timelapse ultrasonic tomography for measuring damage localization in geomechanics laboratory tests.

PubMed

Tudisco, Erika; Roux, Philippe; Hall, Stephen A; Viggiani, Giulia M B; Viggiani, Gioacchino

2015-03-01

Variation of mechanical properties in materials can be detected non-destructively using ultrasonic measurements. In particular, changes in elastic wave velocity can occur due to damage, i.e., micro-cracking and particles debonding. Here the challenge of characterizing damage in geomaterials, i.e., rocks and soils, is addressed. Geomaterials are naturally heterogeneous media in which the deformation can localize, so that few measurements of acoustic velocity across the sample are not sufficient to capture the heterogeneities. Therefore, an ultrasonic tomography procedure has been implemented to map the spatial and temporal variations in propagation velocity, which provides information on the damage process. Moreover, double beamforming has been successfully applied to identify and isolate multiple arrivals that are caused by strong heterogeneities (natural or induced by the deformation process). The applicability of the developed experimental technique to laboratory geomechanics testing is illustrated using data acquired on a sample of natural rock before and after being deformed under triaxial compression. The approach is then validated and extended to time-lapse monitoring using data acquired during plane strain compression of a sample including a well defined layer with different mechanical properties than the matrix.

Jeju ground water containing vanadium induced immune activation on splenocytes of low dose γ-rays-irradiated mice.

PubMed

Ha, Danbee; Joo, Haejin; Ahn, Ginnae; Kim, Min Ju; Bing, So Jin; An, Subin; Kim, Hyunki; Kang, Kyung-goo; Lim, Yoon-Kyu; Jee, Youngheun

2012-06-01

Vanadium, an essential micronutrient, has been implicated in controlling diabetes and carcinogenesis and in impeding reactive oxygen species (ROS) generation. γ-ray irradiation triggers DNA damage by inducing ROS production and causes diminution in radiosensitive immunocytes. In this study, we elucidate the immune activation capacities of Jeju water containing vanadium on immunosuppression caused by γ-ray irradiation, and identify its mechanism using various low doses of NaVO(3). We examined the intracellular ROS generation, DNA damage, cell proliferation, population of splenocytes, and cytokine/antibody profiles in irradiated mice drinking Jeju water for 180 days and in non-irradiated and in irradiated splenocytes both of which were treated with NaVO(3). Both Jeju water and 0.245 μM NaVO(3) attenuated the intracellular ROS generation and DNA damage in splenocytes against γ-ray irradiation. Splenocytes were significantly proliferated by the long-term intake of Jeju water and by 0.245 μM NaVO(3) treatment, and the expansion of B cells accounted for the increased number of splenocytes. Also, 0.245 μM NaVO(3) treatment showed the potency to amplify the production of IFN-γ and total IgG in irradiated splenocytes, which correlated with the expansion of B cells. Collectively, Jeju water containing vanadium possesses the immune activation property against damages caused by γ-irradiation. Copyright © 2012 Elsevier Ltd. All rights reserved.

Fusarium infection causes genotoxic disorders and antioxidant-based damages in Orobanche spp.

PubMed

Aybeke, Mehmet

2017-08-01

This study aims to evaluate the toxic effects of Fusarium oxysporum on root parasitic weed, Orobanche spp. Comparative genetic and gene expression studies were conducted on uninfected and fungus-infected orobanches. In genetic studies, isolated total DNA was amplified by RAPD PCR. Fragment properties were analysed by GTS test. According to the results, the fragment properties of control and Fusarium infected (experimental) groups varied widely; and it has been observed that Fusarium has genotoxic effects on the DNA of orobanches. In gene expression studies, the expression levels of genes encoding enzymes or proteins were associated with ROS damage and toxic effects, therefore, gene expressions of Mn-superoxide dismutase (SOD), Zn-superoxide dismutase (=SOD2, mitochondrial), glutamine synthetase (GS), heat shock protein gene (HSP70), BAX, Caspase-3 and BCL2 were significantly higher in the experimental group. In the light of obtained data, it was concluded that F. oxysporum (1) caused heavy ROS damage in Orobanche (2) induced significant irrevocable genotoxic effects on the DNA of Orobanche, (3) degraded protein metabolism and synthesis, and finally (4) triggered apoptosis. The results of this study can be a ground for further research on reducing the toxic effects of Fusarium on agricultural products, so that advancements in bio-herbicide technology may provide a sustainable agricultural production. Copyright © 2017 Elsevier GmbH. All rights reserved.

Antimicrobial role of human meibomian lipids at the ocular surface.

PubMed

Mudgil, Poonam

2014-10-14

Human meibomian lipids form the outermost lipid layer of the tear film and serve many important functions to maintain its integrity. Although not investigated earlier, these lipids may have antimicrobial properties that help in strengthening the innate host defense of tears at the ocular surface. The aim of this study was to investigate the antimicrobial role of human meibomian lipids. Ocular pathogenic bacteria, Staphylococcus aureus 31, Pseudomonas aeruginosa 19, Pseudomonas aeruginosa 20, and Serratia marcescens 35, were grown in the presence and absence of human meibomian lipids in an artificial tear solution at the physiological temperature. Viable counts were obtained to note the number of bacteria surviving the treatment with meibomian lipids. Bacterial cells were imaged using scanning electron microscopy to observe the damages caused by meibomian lipids. Viable count results showed that in the presence of meibomian lipids, growth of all bacteria was considerably lower. Scanning electron microscopy showed that meibomian lipids caused extensive cellular damage to bacteria as manifested in smaller size, loss of aggregation, abnormal phenotype, cellular distortion, damaged cell wall, and cell lysis. This is the first-ever report of the antimicrobial role of human meibomian lipids. These lipids possess antimicrobial properties against both Gram-positive and Gram-negative bacteria and are involved in the innate host defense of tears in protecting the ocular surface against microbial pathogens. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

Cancer cells recovering from damage exhibit mitochondrial restructuring and increased aerobic glycolysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akakura, Shin; Ostrakhovitch, Elena; Sanokawa-Akakura, Reiko

2014-06-13

Highlights: • Some cancer cells recover from severe damage that causes cell death in majority of cells. • Damage-Recovered (DR) cancer cells show reduced mitochondria, mDNA and mitochondrial enzymes. • DR cells show increased aerobic glycolysis, ATP, cell proliferation, and resistance to damage. • DR cells recovered from in vivo damage also show increased glycolysis and proliferation rate. - Abstract: Instead of relying on mitochondrial oxidative phosphorylation, most cancer cells rely heavily on aerobic glycolysis, a phenomenon termed as “the Warburg effect”. We considered that this effect is a direct consequence of damage which persists in cancer cells that recovermore » from damage. To this end, we studied glycolysis and rate of cell proliferation in cancer cells that recovered from severe damage. We show that in vitro Damage-Recovered (DR) cells exhibit mitochondrial structural remodeling, display Warburg effect, and show increased in vitro and in vivo proliferation and tolerance to damage. To test whether cancer cells derived from tumor microenvironment can show similar properties, we isolated Damage-Recovered (T{sup DR}) cells from tumors. We demonstrate that T{sup DR} cells also show increased aerobic glycolysis and a high proliferation rate. These findings show that Warburg effect and its consequences are induced in cancer cells that survive severe damage.« less

Unguided Rocket Safety: An Informal Compendium of Range Techniques for Assuring Safety in Rocket Testing.

DTIC Science & Technology

1982-03-01

issued when weather conditions are expected that may endanger life or property or which might jeopardize successful completion of range missions...physical data is prepared in advance of the launch day with data supplied by the range user. The rawinsonde deck is created hour(s) prior to the...goal is to contain the flight of all vehicles and to preclude an impact which might endanger human life , cause damage to property, or result in

Self-healing of damage inside metals triggered by electropulsing stimuli.

PubMed

Song, Hui; Wang, Zhong-Jin; He, Xiao-Dong; Duan, Jie

2017-08-02

The microscopic defects that distributed randomly in metals are not only hard to detect, but also may inevitably cause catastrophic failure. Thus, autonomic probing and healing for damage inside metals continue to be a challenging. Here we show a novel approach for self-healing using electropulsing as a stimulus to trigger repairing of damaged metals. This is achieved via a process that through expelling absolutely currents, the microcrack causes them to be redistributed to form a concentrated and a diluted region around it, thereby inducing an extremely high temperature gradient and a large compressive stress, which drive material flow to close microcracks. Simultaneously, a large enough heat for bonding atoms was produced. That is, the microcrack as an empty cavity can be regarded as a special micro-device to shape a localized microscopic energy field, which in turn activates a healing process. The microstructure and mechanical property verified the extrinsic self-healing of a titanium alloy. The process is performed on a short timescale, is enable to detect automatically and act directly on the internal defects in metals, and to heal damage without any healing agent, long time heating as well as applied high pressure, offering unique advantages over conventional healing approaches.

Antimicrobial property of zinc based nanoparticles

NASA Astrophysics Data System (ADS)

Chiriac, V.; Stratulat, D. N.; Calin, G.; Nichitus, S.; Burlui, V.; Stadoleanu, C.; Popa, M.; Popa, I. M.

2016-06-01

Pathogen bacteria strains with wide spectrum can cause serious infections with drastic damages on humans. There are studies reflecting antibacterial effect of nanoparticles type metal or metal oxides as an alternative or concurrent treatment to the diseases caused by infectious agents. Synthesised nanoparticles using different methods like sol-gel, hydrothermal or plant extraction were tested following well-established protocols with the regard to their antimicrobial activity. It was found that zinc based nanoparticles possess strong synergistic effect with commonly used antibiotics on infection tratment.

Observing storm surges from satellite altimetry

NASA Astrophysics Data System (ADS)

Han, Guoqi

2016-07-01

Storm surges can cause catastrophic damage to properties and loss of life in coastal communities. Thus it is important to enhance our capabilities of observing and forecasting storm surges for mitigating damage and loss. In this presentation we show examples of observing storm surges around the world using nadir satellite altimetry, during Hurricane Sandy, Igor, and Isaac, as well as other cyclone events. The satellite observations are evaluated against tide-gauge observations and discussed for dynamic mechanisms. We also show the potential of a new wide-swath altimetry mission, the Surface Water and Ocean Topography (SWOT), for observing storm surges.

Stress and Damage in Polymer Matrix Composite Materials Due to Material Degradation at High Temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mcmanus, H.L.; Chamis, C.C.

1996-01-01

This report describes analytical methods for calculating stresses and damage caused by degradation of the matrix constituent in polymer matrix composite materials. Laminate geometry, material properties, and matrix degradation states are specified as functions of position and time. Matrix shrinkage and property changes are modeled as functions of the degradation states. The model is incorporated into an existing composite mechanics computer code. Stresses, strains, and deformations at the laminate, ply, and micro levels are calculated, and from these calculations it is determined if there is failure of any kind. The rationale for the model (based on published experimental work) ismore » presented, its integration into the laminate analysis code is outlined, and example results are given, with comparisons to existing material and structural data. The mechanisms behind the changes in properties and in surface cracking during long-term aging of polyimide matrix composites are clarified. High-temperature-material test methods are also evaluated.« less

Feasibility study for eradication of Reticulitermes flavipes from Endeavor, Wisconsin

Treesearch

Rachel A. Arango; Frederick Green

2007-01-01

Establishment of the Eastern subterranean termite, Reticulitermes flavipes in Endeavor, Wisconsin, in the early 1980s has caused significant damage to homes, businesses, and village properties over the years. Though precise reasons for successful establishment of the colony are still to be determined, we believe that the nearby lake and low-lying sandy soils have...

Predicting the economic costs and property value losses attributed to sudden oak death damage in California (2010-2020)

Treesearch

Kent Kovacs; Tomas Václavík; Robert G. Haight; Arwin Pang; Nik J. Cunniffe; Christopher A. Gilligan; Ross K. Meentemeyer

2011-01-01

Phytophthora ramorum, cause of sudden oak death, is a quarantined, non-native, invasive forest pathogen resulting in substantial mortality in coastal live oak (Quercus agrifolia) and several other related tree species on the Pacific Coast of the United States. We estimate the discounted cost of oak treatment, removal, and...

14 CFR 1261.103 - Time limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Time limitations. 1261.103 Section 1261.103...) Employees' Personal Property Claims § 1261.103 Time limitations. (a) A claim may be allowed only if the... accrues at the time of the accident or incident causing the loss or damage, or at such time as the loss or...

14 CFR 1261.103 - Time limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Time limitations. 1261.103 Section 1261.103...) Employees' Personal Property Claims § 1261.103 Time limitations. (a) A claim may be allowed only if the... accrues at the time of the accident or incident causing the loss or damage, or at such time as the loss or...

14 CFR 1261.103 - Time limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Time limitations. 1261.103 Section 1261.103...) Employees' Personal Property Claims § 1261.103 Time limitations. (a) A claim may be allowed only if the... accrues at the time of the accident or incident causing the loss or damage, or at such time as the loss or...

Tornado Protection: Selecting and Designing Safe Areas in Buildings.

ERIC Educational Resources Information Center

Abernethy, James J.

Tornadoes and extreme winds cause heavy loss of life and property damage throughout the United States. Most buildings offer significant protection from this danger, and building administrators should know the areas where this protection is available. This booklet presents a review of three schools, all of which were struck by tornadoes on April 3,…

Fusion of Remote Sensing and Non-Authoritative Data for Flood Disaster and Transportation Infrastructure Assessment

ERIC Educational Resources Information Center

Schnebele, Emily K.

2013-01-01

Flooding is the most frequently occurring natural hazard on Earth; with catastrophic, large scale floods causing immense damage to people, property, and the environment. Over the past 20 years, remote sensing has become the standard technique for flood identification because of its ability to offer synoptic coverage. Unfortunately, remote sensing…

Blowing dust and highway safety in the southwestern United States: Characteristics of dust emission "hotspots" and management implications

USDA-ARS?s Scientific Manuscript database

Despite the widespread media attention of chain-reaction traffic incidents and property damage caused by windblown dust in the U.S. and elsewhere in the world, very few studies have provided in-depth analysis on this issue. Remote sensing and field observations reveal that wind erosion in the southw...

41 CFR 102-72.69 - What additional terms and conditions apply to an Executive agencies' delegation of ancillary...

Code of Federal Regulations, 2014 CFR

2014-01-01

... alteration work, the Executive agency shall deliver, or cause its contractor to deliver, to the building... liability and property damage insurance policies to cover claims arising from or relating to the contractor... liability, either directly or indirectly, for any contractual claims or disputes that arise out of or relate...

41 CFR 102-72.69 - What additional terms and conditions apply to an Executive agencies' delegation of ancillary...

Code of Federal Regulations, 2013 CFR

2013-07-01

... alteration work, the Executive agency shall deliver, or cause its contractor to deliver, to the building... liability and property damage insurance policies to cover claims arising from or relating to the contractor... liability, either directly or indirectly, for any contractual claims or disputes that arise out of or relate...

41 CFR 102-72.69 - What additional terms and conditions apply to an Executive agencies' delegation of ancillary...

Code of Federal Regulations, 2011 CFR

2011-01-01

... alteration work, the Executive agency shall deliver, or cause its contractor to deliver, to the building... liability and property damage insurance policies to cover claims arising from or relating to the contractor... liability, either directly or indirectly, for any contractual claims or disputes that arise out of or relate...

41 CFR 102-72.69 - What additional terms and conditions apply to an Executive agencies' delegation of ancillary...

Code of Federal Regulations, 2010 CFR

2010-07-01

... alteration work, the Executive agency shall deliver, or cause its contractor to deliver, to the building... liability and property damage insurance policies to cover claims arising from or relating to the contractor... liability, either directly or indirectly, for any contractual claims or disputes that arise out of or relate...

Efficient initial attacks: analysis of capacity and funding provides insights to wildfire protection planning

Treesearch

Jeremy Fried; Paul Meznarich

2014-01-01

Large wildfires in the United States pose significant challenges to fire management agencies charged with protecting lives, property, and natural resources. A vigorous initial response to a wildfire, a process referred to as "initial attack," can greatly reduce the likelihood of the fire becoming larger and causing substantial damage. Successful...

Economic valuation of landslide damage in hilly regions: a case study from Flanders, Belgium.

PubMed

Vranken, Liesbet; Van Turnhout, Pieter; Van Den Eeckhaut, Miet; Vandekerckhove, Liesbeth; Poesen, Jean

2013-03-01

Several regions around the globe are at risk of incurring damage from landslides, but only few studies have concentrated on a quantitative estimate of the overall damage caused by landslides at a regional scale. This study therefore starts with a quantitative economic assessment of the direct and indirect damage caused by landslides in a 2,910 km study area located west of Brussels, a low-relief region susceptible to landslides. Based on focus interviews as well as on semi-structured interviews with homeowners, civil servants and the owners and providers of lifelines such as electricity and sewage, a quantitative damage assessment is provided. For private properties (houses, forest and pasture land) we estimate the real estate and production value losses for different damage scenarios, while for public infrastructure the costs of measures to repair and prevent landslide induced damage are estimated. In addition, the increase in amenity value of forests and grasslands due to the occurrence of landslides is also calculated. The study illustrates that a minority of land (only 2.3%) within the study area is used for dwellings, roads and railway lines, but that these land use types are responsible for the vast majority of the economic damage due to the occurrence of landslides. The annual cost of direct damage due to landsliding amounts to 688,148 €/year out of which 550,740 €/year for direct damage to houses, while the annual indirect damage augments to 3,020,049 €/year out of which 2,007,375 €/year for indirect damage to real estate. Next, the study illustrates that the increase of the amenity value of forests and grasslands outweighs the production value loss. As such the study does not only provide quantitative input data for the estimation of future risks, but also important information for government officials as it clearly informs about the costs associated with certain land use types in landslide areas. Copyright © 2013 Elsevier B.V. All rights reserved.

29 CFR 15.205 - What types of claims for property damage are allowed under the MPCECA?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 1 2013-07-01 2013-07-01 false What types of claims for property damage are allowed under... Civilian Employees' Claims Act of 1964 § 15.205 What types of claims for property damage are allowed under the MPCECA? (a) Claims for property damage are allowed under the MPCECA only if the property involved...

29 CFR 15.205 - What types of claims for property damage are allowed under the MPCECA?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 1 2014-07-01 2013-07-01 true What types of claims for property damage are allowed under... Civilian Employees' Claims Act of 1964 § 15.205 What types of claims for property damage are allowed under the MPCECA? (a) Claims for property damage are allowed under the MPCECA only if the property involved...

Impact Behavior of Composite Fan Blade Leading Edge Subcomponent with Thermoplastic Polyurethane Interleave

NASA Technical Reports Server (NTRS)

Miller, Sandi G.; Roberts, Gary D.; Kohlman, Lee W.; Heimann, Paula J.; Pereira, J. Michael; Ruggeri, Charles R.; Martin, Richard E.; McCorkle, Linda S.

2015-01-01

Impact damage tolerance and damage resistance is a critical metric for application of polymer matrix composites where failure caused by impact damage could compromise structural performance and safety. As a result, several materials and/or design approaches to improve impact damage tolerance have been investigated over the past several decades. Many composite toughening methodologies impart a trade-off between increased fracture toughness and compromised in-plane strength and modulus. In large part, mechanical tests to evaluate composite damage tolerance include static methods such as Mode I, Mode II, and mixed mode failures. However, ballistic impact damage resistance does not always correlate with static properties. The intent of this paper is to evaluate the influence of a thermoplastic polyurethane veil interleave on the static and dynamic performance of composite test articles. Static coupon tests included tension, compression, double cantilever beam, and end notch flexure. Measurement of the resistance to ballistic impact damage were made to evaluate the composites response to high speed impact. The interlayer material showed a decrease of in-plane performance with only a moderate improvement to Mode I and Mode II fracture toughness. However, significant benefit to impact damage tolerance was observed through ballistic tests.

Hydraulic Physical Model of Debris Flow for Malaysia Case Study

NASA Astrophysics Data System (ADS)

Arif Zainol, M. R. R. Mohd; Awahab, M. K.

2018-06-01

In the recent decade, several debris flow events occurred and caused hundreds of deaths, missing or injury and damaged many facilities. In addition to causing significant morphological changes along riverbeds and mountain slopes, these flows are frequently reported to bring about extensive property damage and loss of life. Debris flow phenomena occasionally occur in Malaysia and numbers of death reported cause by this event. In order to investigate the debris flow and its deposition process, experiments were conducted at the School of Civil Engineering Laboratory, Universiti Sains Malaysia. The models consists of three main parts which are water tank, rectangular flume and deposition board. A high speed video camera (HSVC) had been placed nearly downstream of the rectangular flume to capture the movement characteristics of particle grain. From this study, the characteristics of particle routing segregation can be understand clearly, therefore this input will be a very useful information to other researchers for further investigation in terms of knowledge sharing between researchers. Catastrophic cause by debris flow event can be minimized therefore in term of economy losses can be reduce and human life can be safe.

Floods of January and February 1980 in California

USGS Publications Warehouse

Wahl, Kenneth L.; Crippen, John R.; Knott, J.M.

1980-01-01

During January and February 1980, storms caused substantial rises in streamflow throughout much of California. In mid-January flooding occurred in the foothills of the Sierra Nevada and in the central coast area. In late January and mid-February, high floodflows in streams in coastal southern California caused much damage and several deaths. The Tijuana River in northern Baja California (Mexico) and southern San Diego County flooded many square miles of lowlands as its flow during two separate flooding episodes exceeded all records. Most reservoirs in San Diego County spilled, several for the first time since their completion. Lake Elsinore, in eastern Riverside County, caused much damage to lakeside property as it filled to an elevation not reached since 1916. The February flooding in southern California was caused by a series of storms separated by short intervals. Some peaks of record were observed, and streamflow throughout the area remained high for a relatively long period. In many streams, the volumes of sustained flow for periods of 7 and 15 consecutive days were the greatest that have occurred during the period of record.

Effects of the earthquake of March 27, 1964, at Anchorage, Alaska: Chapter A in The Alaska earthquake, March 27, 1964: effects on communities

USGS Publications Warehouse

Hansen, Wallace R.

1965-01-01

Anchorage, Alaska’s largest city, is about 80 miles west-northwest of the epicenter of the March 27 earthquake. Because of its size, Anchorage bore the brunt of property damage from the quake; it sustained greater losses than all the rest of Alaska combined. Damage was caused by direct seismic vibration, by ground cracks, and by landslides. Direct seismic vibration affected chiefly multistory buildings and buildings having large floor areas, probably because of the long period and large amplitude of the seismic waves reaching Anchorage. Most small buildings were spared. Ground cracks caused capricious damage throughout the Anchorage Lowland. Cracking was mast prevalent near the heads or within landslides but was also widespread elsewhere. Landslides themselves caused the most devastating damage. Triggering of landslides by the earthquake was related to the physical-engineering properties of the Bootlegger Cove Clay, a glacial estuarine-marine deposit that underlies much of the Anchorage area. The Bootlegger Cove Clay contains zones of low shear strength, high water content, and high sensitivity that failed under the vibratory stress of the earthquake. Shear strength in sensitive zones ranged from less than 0.2 tsf to about 0.5 tsf; sensitivity ranged from about 10 to more than 40. Sensitive zones generally are centered about 10 to 20 feet above sea level, between zones of stiff insensitive clay. Many physical tests by the U.S. Army Corps of Engineers were directed toward analyzing the causes of failure in the Bootlegger Cove Clay and finding possible remedies. Strengths and sensitivities were measured directly in the field by means of vane shear apparatus. A4tterberg limits, natural water contents, triaxial shear, sensitivity, dynamic modulus, consolidation strength, and other properties were measured in the laboratory. Pulsating-load tests simulated earthquake loading. Most of the destructive landslides in the Anchorage area moved primarily by translation rather than by rotation. Thus, all the highly damaging slides were of a single structural dynamic family despite wide variations in size, appearance, and complexity. They slid on nearly horizontal slip surfaces after loss of strength in the Bootlegger Core Clay. Same failures are attributed to spontaneous liquefaction of sand layers. All translatory slides surmounted flat-topped bluffs bounded marginally by steep slopes facing lower ground. Destructive translatory slides occurred in the downtown area (Fourth Avenue slide and L Street slide), at Government Hill, and at Turnagain Heights. Less destructive slides occurred in many other places-mostly uninhabited or undeveloped areas. In most translatory slides, damage was greatest in graben areas at the head and in pressure-ridge areas at the toe. Many buildings inside the perimeters of slide blocks were little damaged despite horizontal translations of several feet. The large Turnagain Heights slide, however, was characterized by a complete disintegration and drastic lowering of the prequake land surface. Extensive damage back from the slide, moreover, was caused by countless tension cracks. An approximation of the depth of failure in the Bootlegger Cove Clay in the various slides may be obtained by using a geometric relationship herein called the "graben rule." Because the cross-sectional area of the graben at the head of the slide approximated the cross-sectional area of the space voided behind the slide block as the block moved outward, the depth of failure was equal to the area of the graben divided by the lateral displacement. This approximation supplements and accords with test data obtained from borings. The graben rule should apply to any translatory slide in which flowage of material from the zone of failure has not been excessive. Geologic evidence indicates that landslides similar to those triggered by the March 27 earthquake have occurred in the Anchorage area at various times in the past.

Urban Flood Management with Integrated Inland-River System in Seoul

NASA Astrophysics Data System (ADS)

Moon, Y. I.; Kim, J. S.; Yuk, J. M.

2015-12-01

Global warming and climate change have caused significant damage and loss of life worldwide. The pattern of natural disasters has gradually diversified and their frequency is increasing. The impact of climate change on flood risk in urban rivers is of particular interest because these areas are typically densely populated. The occurrence of urban river flooding due to climate change not only causes significant loss of life and property but also causes health and social problems. It is therefore necessary to develop a scientific urban flood management system to cope with and reduce the impacts of climate change, including flood damage. In this study, we are going to introduce Integrated Inland-River Flood Analysis System in Seoul to conduct predictions on flash rain or short-term rainfall by using radar and satellite information and perform prompt and accurate prediction on the inland flooded areas. In addition, this urban flood management system can be used as a tool for decision making of systematic disaster prevention through real-time monitoring.

Challenges in Modelling of Lightning-Induced Delamination; Effect of Temperature-Dependent Interfacial Properties

NASA Technical Reports Server (NTRS)

Naghipour, P.; Pineda, E. J.; Arnold, S.

2014-01-01

Lightning is a major cause of damage in laminated composite aerospace structures during flight. Due to the dielectric nature of Carbon fiber reinforced polymers (CFRPs), the high energy induced by lightning strike transforms into extreme, localized surface temperature accompanied with a high-pressure shockwave resulting in extensive damage. It is crucial to develop a numerical tool capable of predicting the damage induced from a lightning strike to supplement extremely expensive lightning experiments. Delamination is one of the most significant failure modes resulting from a lightning strike. It can be extended well beyond the visible damage zone, and requires sophisticated techniques and equipment to detect. A popular technique used to model delamination is the cohesive zone approach. Since the loading induced from a lightning strike event is assumed to consist of extreme localized heating, the cohesive zone formulation should additionally account for temperature effects. However, the sensitivity to this dependency remains unknown. Therefore, the major focus point of this work is to investigate the importance of this dependency via defining various temperature dependency profiles for the cohesive zone properties, and analyzing the corresponding delamination area. Thus, a detailed numerical model consisting of multidirectional composite plies with temperature-dependent cohesive elements in between is subjected to lightning (excessive amount of heat and pressure) and delamination/damage expansion is studied under specified conditions.

Electron beam induced radiation damage in the catalyst layer of a proton exchange membrane fuel cell.

PubMed

He, Qianping; Chen, Jihua; Keffer, David J; Joy, David C

2014-01-01

Electron microscopy is an essential tool for the evaluation of microstructure and properties of the catalyst layer (CL) of proton exchange membrane fuel cells (PEMFCs). However, electron microscopy has one unavoidable drawback, which is radiation damage. Samples suffer temporary or permanent change of the surface or bulk structure under radiation damage, which can cause ambiguity in the characterization of the sample. To better understand the mechanism of radiation damage of CL samples and to be able to separate the morphological features intrinsic to the material from the consequences of electron radiation damage, a series of experiments based on high-angle annular dark-field-scanning transmission scanning microscope (HAADF-STEM), energy filtering transmission scanning microscope (EFTEM), and electron energy loss spectrum (EELS) are conducted. It is observed that for thin samples (0.3-1 times λ), increasing the incident beam energy can mitigate the radiation damage. Platinum nanoparticles in the CL sample facilitate the radiation damage. The radiation damage of the catalyst sample starts from the interface of Pt/C or defective thin edge and primarily occurs in the form of mass loss accompanied by atomic displacement and edge curl. These results provide important insights on the mechanism of CL radiation damage. Possible strategies of mitigating the radiation damage are provided. © 2013 Wiley Periodicals, Inc.

Damage Proxy Map from InSAR Coherence Applied to February 2011 M6.3 Christchurch Earthquake, 2011 M9.0 Tohoku-oki Earthquake, and 2011 Kirishima Volcano Eruption

NASA Astrophysics Data System (ADS)

Yun, S.; Agram, P. S.; Fielding, E. J.; Simons, M.; Webb, F.; Tanaka, A.; Lundgren, P.; Owen, S. E.; Rosen, P. A.; Hensley, S.

2011-12-01

Under ARIA (Advanced Rapid Imaging and Analysis) project at JPL and Caltech, we developed a prototype algorithm to detect surface property change caused by natural or man-made damage using InSAR coherence change. The algorithm was tested on building demolition and construction sites in downtown Pasadena, California. The developed algorithm performed significantly better, producing 150 % higher signal-to-noise ratio, than a standard coherence change detection method. We applied the algorithm to February 2011 M6.3 Christchurch earthquake in New Zealand, 2011 M9.0 Tohoku-oki earthquake in Japan, and 2011 Kirishima volcano eruption in Kyushu, Japan, using ALOS PALSAR data. In Christchurch area we detected three different types of damage: liquefaction, building collapse, and landslide. The detected liquefaction damage is extensive in the eastern suburbs of Christchurch, showing Bexley as one of the most significantly affected areas as was reported in the media. Some places show sharp boundaries of liquefaction damage, indicating different type of ground materials that might have been formed by the meandering Avon River in the past. Well reported damaged buildings such as Christchurch Cathedral, Canterbury TV building, Pyne Gould building, and Cathedral of the Blessed Sacrament were detected by the algorithm. A landslide in Redcliffs was also clearly detected. These detected damage sites were confirmed with Google earth images provided by GeoEye. Larger-scale damage pattern also agrees well with the ground truth damage assessment map indicated with polygonal zones of 3 different damage levels, compiled by the government of New Zealand. The damage proxy map of Sendai area in Japan shows man-made structure damage due to the tsunami caused by the M9.0 Tohoku-oki earthquake. Long temporal baseline (~2.7 years) and volume scattering caused significant decorrelation in the farmlands and bush forest along the coastline. The 2011 Kirishima volcano eruption caused a lot of ash fall deposit in the southeast from the volcano. The detected ash fall damage area exactly matches the in-situ measurements implemented through fieldwork by Geological Survey of Japan. With 99-percentile threshold for damage detection, the periphery of the detected damage area aligns with a contour line of 100 kg/m2 ash deposit, equivalent to 10 cm of depth assuming a density of 1000 kg/m3 for the ash layer. With growing number of InSAR missions, rapidly produced accurate damage assessment maps will help save people, assisting effective prioritization of rescue operations at early stage of response, and significantly improve timely situational awareness for emergency management and national / international assessment and response for recovery planning. Results of this study will also inform the design of future InSAR missions including the proposed DESDynI.

Resurfacing Damaged Articular Cartilage to Restore Compressive Properties

PubMed Central

Grenier, Stephanie; Donnelly, Patrick E.; Gittens, Jamila; Torzilli, Peter A.

2014-01-01

Surface damage to articular cartilage is recognized as the initial underlying process causing the loss of mechanical function in early-stage osteoarthritis. In this study, we developed structure-modifying treatments to potentially prevent, stabilize or reverse the loss in mechanical function. Various polymers (chondroitin sulfate, carboxymethylcellulose, sodium hyaluronate) and photoinitiators (riboflavin, irgacure 2959) were applied to the surface of collagenase-degraded cartilage and crosslinked in situ using UV light irradiation. While matrix permeability and deformation significantly increased following collagenase-induced degradation of the superficial zone, resurfacing using tyramine-substituted sodium hyaluronate and riboflavin decreased both values to a level comparable to that of intact cartilage. Repetitive loading of resurfaced cartilage showed minimal variation in the mechanical response over a 7 day period. Cartilage resurfaced using a low concentration of riboflavin had viable cells in all zones while a higher concentration resulted in a thin layer of cell death in the uppermost superficial zone. Our approach to repair surface damage initiates a new therapeutic advance in the treatment of injured articular cartilage with potential benefits that include enhanced mechanical properties, reduced susceptibility to enzymatic degradation and reduced adhesion of macrophages. PMID:25468298

Overview of landslide problems, research, and mitigation, Cincinnati, Ohio, area

USGS Publications Warehouse

Baum, Rex L.; Johnson, Arvid M.

1996-01-01

Landslides cause much damage to property throughout the metropolitan area of Cincinnati, Ohio. Most landslides occur in unconsolidated deposits, including colluvium, till, glacial lake clays, and man-made fill derived from colluvium and glacial deposits. Landslides in thin colluvium are widespread on steeper slopes that wall the valleys of the Ohio River and its tributaries. Abundant landslides also form in thick colluvium on flatter slopes, especially where the colluvium has been disturbed by earthwork. Unusual block glides and block-extrusion glides form where till rests on lake clay. Through the years, knowledge of the distribution and causes of landslides has increased as a result of many investigations. This knowledge became part of the basis for landslide mitigation programs adopted by the City of Cincinnati and Hamilton County, Ohio. In 1974 the Cincinnati City Council passed an excavation and fill ordinance to help reduce landslide damage in areas of new construction. In 1989 following much additional study, Cincinnati created a geotechnical office within its Department of Public Works. The office, which is staffed by a geotechnical engineer, an engineering geologist, and two technicians, carries out a mitigation program. Since 1989, members of the geotechnical staff have worked in several ways to reduce landslide damage in the city; their work includes engineering-geologic mapping of selected parts of the city, inspection of retaining walls that impact public right-of-way, review of proposed construction in hillside areas, inspecting and arranging for repair of landslide areas that affect city property, and compiling geologic and geotechnical data on landslide areas within the city. In 1990, Hamilton County also adopted an excavation and fill ordinance to help reduce the damage due to landslides in areas of new construction.

MULTI-LABORATORY STUDY OF FLOW-INDUCED HEMOLYSIS USING THE FDA BENCHMARK NOZZLE MODEL

PubMed Central

Herbertson, Luke H.; Olia, Salim E.; Daly, Amanda; Noatch, Christopher P.; Smith, William A.; Kameneva, Marina V.; Malinauskas, Richard A.

2015-01-01

Multilaboratory in vitro blood damage testing was performed on a simple nozzle model to determine how different flow parameters and blood properties affect device-induced hemolysis and to generate data for comparison with computational fluid dynamics-based predictions of blood damage as part of an FDA initiative for assessing medical device safety. Three independent laboratories evaluated hemolysis as a function of nozzle entrance geometry, flow rate, and blood properties. Bovine blood anticoagulated with acid citrate dextrose solution (2–80 h post-draw) was recirculated through nozzle-containing and paired nozzle-free control loops for 2 h. Controlled parameters included hematocrit (36 ± 1.5%), temperature (25°C), blood volume, flow rate, and pressure. Three nozzle test conditions were evaluated (n = 26–36 trials each): (i) sudden contraction at the entrance with a blood flow rate of 5 L/min, (ii) gradual cone at the entrance with a 6-L/min blood flow rate, and (iii) sudden-contraction inlet at 6 L/min. The blood damage caused only by the nozzle model was calculated by subtracting the hemolysis generated by the paired control loop test. Despite high intralaboratory variability, significant differences among the three test conditions were observed, with the sharp nozzle entrance causing the most hemolysis. Modified index of hemolysis (MIHnozzle) values were 0.292 ± 0.249, 0.021 ± 0.128, and 1.239 ± 0.667 for conditions i–iii, respectively. Porcine blood generated hemolysis results similar to those obtained with bovine blood. Although the interlaboratory hemolysis results are only applicable for the specific blood parameters and nozzle model used here, these empirical data may help to advance computational fluid dynamics models for predicting blood damage. PMID:25180887

Research on Damage Identification of Bridge Based on Digital Image Measurement

NASA Astrophysics Data System (ADS)

Liang, Yingjing; Huan, Shi; Tao, Weijun

2017-12-01

In recent years, the number of the damage bridge due to excessive deformation gradually increased, which caused significant property damage and casualties. Hence health monitoring and the damage detection of the bridge structure based on the deflection measurement are particularly important. The current conventional deflection measurement methods, such as total station, connected pipe, GPS, etc., have many shortcomings as low efficiency, heavy workload, low degree of automation, operating frequency and working time constrained. GPS has a low accuracy in the vertical displacement measurement and cannot meet the dynamic measured requirements of the current bridge engineering. This paper presents a bridge health monitoring and damage detection technology based on digital image measurement method in which the measurement accuracy is sub-millimeter level and can achieve the 24-hour automatic non-destructive monitoring for the deflection. It can be concluded from this paper that it is feasible to use digital image measurement method for identification of the damage in the bridge structure, because it has been validated by the theoretical analysis, the laboratory model and the application of the real bridge.

The effects of global climate change on Southeast Asia: A survey of likely impacts and problems of adaptation

NASA Technical Reports Server (NTRS)

Njoto, Sukrisno; Howe, Charles W.

1991-01-01

Study results indicate the likelihood of significant net damages from climate change, in particular damages from sea-level rise and higher temperatures that seem unlikely to be offset by favorable shifts in precipitation and carbon dioxide. Also indicated was the importance of better climate models, in particular models that can calculate climate change on a regional scale appropriate to policy-making. In spite of this potential for damage, there seems to be a low level of awareness and concern, probably caused by the higher priority given to economic growth and reinforced by the great uncertainty in the forecasts. The common property nature of global environment systems also leads to a feeling of helplessness on the part of country governments.

Assessment of concrete damage and strength degradation caused by reinforcement corrosion

NASA Astrophysics Data System (ADS)

Nepal, Jaya; Chen, Hua-Peng

2015-07-01

Structural performance deterioration of reinforced concrete structures has been extensively investigated, but very limited studies have been carried out to investigate the effect of reinforcement corrosion on time-dependent reliability with consideration of the influence of mechanical characteristics of the bond interface due to corrosion. This paper deals with how corrosion in reinforcement creates different types of defects in concrete structure and how they are responsible for the structural capacity deterioration of corrosion affected reinforced concrete structures during their service life. Cracking in cover concrete due to reinforcement corrosion is investigated by using rebar-concrete model and realistic concrete properties. The flexural strength deterioration is analytically predicted on the basis of bond strength evolution due to reinforcement corrosion, which is examined by the experimental data available. The time-dependent reliability analysis is undertaken to calculate the life time structural reliability of corrosion damaged concrete structures by stochastic deterioration modelling of reinforced concrete. The results from the numerical example show that the proposed approach is capable of evaluating the damage caused by reinforcement corrosion and also predicting the structural reliability of concrete structures during their lifecycle.

Biophysical and medical safety basis of laser emission

NASA Astrophysics Data System (ADS)

Paltsev, Yu.; Levina, A.

1996-01-01

Laser equipment may inflict serious losses to human health if safety norms established by relevant standards and other documentation are not properly observed. It is explained by physical properties of laser emission (LE) which differs from general light sources by quantitative behavior of such parameters as the degrees of coherence, monochromaticity, brightness, polarization. Thus, biological effects due to laser emission, as a rule, are more expressed comparing with other types of emission from other spontaneous light sources. LE effects biological tissues through the density of energy flow and impulse duration. It is common knowledge nowadays that LE biological action is assessed by two criteria: physical parameters and absorptive properties of tissues exposed to rays. LE causes the greatest danger to the eyes due to their specific structure. The next target organ vulnerable to LE is skin. Pathological changes of skin depend on the LE power, time of exposure, wave length, and the extent of skin pigmentation. Along with different kinds of damage directly in the tissues exposed to rays, LE may cause changes in organs and body systems subject to indirect exposure. It is important that these changes may develop due to low intensity levels of LE that do not cause local damage. National and international standards on LE safety are based on maximum allowable levels (MAL) of exposure. It has been generally accepted that the main MAL criterion is LE threshold minimal exposure which causes damage to retina, eyes, and skin. As distinct from foreign safety standards, hygienic norms and regulations are in force in the Russian Federation where additional co-efficients along with standard generally accepted MAL values have been introduced for the persons who are subject to occupational regular exposure to lasers. This approach has been chosen after the results of follow-up and health studies of these occupational contingents have been analyzed, and experiments on laboratory animals assessed.

Evaluation of a portable MOS electronic nose to detect root rots in shade tree species

Treesearch

Manuela Baietto; Letizia Pozzi; Alphus Dan Wilson; Daniele Bassi

2013-01-01

The early detection of wood decays in high-value standing trees is very important in urban areas because mitigating control measures must be implemented long before tree failures result in property damage or injuries to citizens. Adverse urban environments increase physiological stresses in trees, causing greater susceptibility to attacks by pathogenic decay fungi. The...

Frequency analyses for recent regional floods in the United States

USGS Publications Warehouse

Melcher, Nick B.; Martinez, Patsy G.; ,

1996-01-01

During 1993-95, significant floods that resulted in record-high river stages, loss of life, and significant property damage occurred in the United States. The floods were caused by unique global weather patterns that produced large amounts of rain over large areas. Standard methods for flood-frequency analyses may not adequately consider the probability of recurrence of these global weather patterns.

76 FR 63200 - Safety Zone; The Old Club Cannonade, Lake St. Clair, Muscamoot Bay, Harsens Island, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

.... Department of Transportation, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE... into Lake St. Clair could cause death, serious bodily harm, or property damage. Discussion of Rule....5' N, 082[deg]40.6' W then angling southeast to the point of origin creating a triangle shaped...

Soil hydraulic characteristics of a small southwest Oregon watershed following high-intensity wildfires

Treesearch

David S. Parks; Terrance W. Cundy

1989-01-01

The Angel Fire of September, 1987 caused extensive damage to second growth forest in the south fork drainage of Cow Creek, 55 km northeast of Grant's Pass, Oregon, USA. The fire was characterized by a high-intensity burn over areas of steep topography. The areal distribution of soil hydraulic properties in a small, tributary watershed following high-intensity...

Numerical simulation of microstructural damage and tensile strength of snow

NASA Astrophysics Data System (ADS)

Hagenmuller, Pascal; Theile, Thiemo C.; Schneebeli, Martin

2014-01-01

This contribution uses finite-element analysis to simulate microstructural failure processes and the tensile strength of snow. The 3-D structure of snow was imaged by microtomography. Modeling procedures used the elastic properties of ice with bond fracture assumptions as inputs. The microstructure experiences combined tensile and compressive stresses in response to macroscopic tensile stress. The simulated nonlocalized failure of ice lattice bonds before or after reaching peak stress creates a pseudo-plastic yield curve. This explains the occurrence of acoustic events observed in advance of global failure. The measured and simulated average tensile strengths differed by 35%, a typical range for strength measurements in snow given its low Weibull modulus. The simulation successfully explains damage, fracture nucleation, and strength according to the geometry of the microstructure of snow and the mechanical properties of ice. This novel method can be applied to more complex snow structures including the weak layers that cause avalanches.

Numerical simulation of flood barriers

NASA Astrophysics Data System (ADS)

Srb, Pavel; Petrů, Michal; Kulhavý, Petr

This paper deals with testing and numerical simulating of flood barriers. The Czech Republic has been hit by several very devastating floods in past years. These floods caused several dozens of causalities and property damage reached billions of Euros. The development of flood measures is very important, especially for the reduction the number of casualties and the amount of property damage. The aim of flood control measures is the detention of water outside populated areas and drainage of water from populated areas as soon as possible. For new flood barrier design it is very important to know its behaviour in case of a real flood. During the development of the barrier several standardized tests have to be carried out. Based on the results from these tests numerical simulation was compiled using Abaqus software and some analyses were carried out. Based on these numerical simulations it will be possible to predict the behaviour of barriers and thus improve their design.

Expansive Soil Crack Depth under Cumulative Damage

PubMed Central

Shi, Bei-xiao; Chen, Sheng-shui; Han, Hua-qiang; Zheng, Cheng-feng

2014-01-01

The crack developing depth is a key problem to slope stability of the expansive soil and its project governance and the crack appears under the roles of dry-wet cycle and gradually develops. It is believed from the analysis that, because of its own cohesion, the expansive soil will have a certain amount of deformation under pulling stress but without cracks. The soil body will crack only when the deformation exceeds the ultimate tensile strain that causes cracks. And it is also believed that, due to the combined effect of various environmental factors, particularly changes of the internal water content, the inherent basic physical properties of expansive soil are weakened, and irreversible cumulative damages are eventually formed, resulting in the development of expansive soil cracks in depth. Starting from the perspective of volumetric strain that is caused by water loss, considering the influences of water loss rate and dry-wet cycle on crack developing depth, the crack developing depth calculation model which considers the water loss rate and the cumulative damages is established. Both the proposal of water loss rate and the application of cumulative damage theory to the expansive soil crack development problems try to avoid difficulties in matrix suction measurement, which will surely play a good role in promoting and improving the research of unsaturated expansive soil. PMID:24737974

Tremors from earthquakes and blasting in the Powder River basin of Wyoming and Montana

USGS Publications Warehouse

Miller, C.H.; Osterwald, F.W.

1980-01-01

We are not aware of any damage to people or to property caused by blasting in the coal surface mines even though thousands of tons of explosives are detonated each year in the basin. The maximum weight of an individual explosive charge and the time interval between blasts are regulated so that any nearby structures will not be damaged or the residents disturbed. Blasting, nevertheless, does produce seismic tremors that can be recorded over 200 kilometers away. In addition, at one mine, some very low order aftershocks were recorded relatively close to the source within 2 hours after blasting.  

Free radical development in phacoemulsification cataract surgery.

PubMed

Takahashi, Hiroshi

2005-02-01

Phacoemulsification and aspiration (PEA) has become the most popular cataract surgery, due to the establishment of safe surgical techniques and development of associated instruments. However, corneal endothelial damage still represents a serious complication, as excessive damage can lead to irreversible bullous keratopathy. In addition to causes such as mechanical or heat injuries, free radical formation due to ultrasound has been posited as another cause of corneal endothelium damage in PEA. Ultrasound in aqueous solution induces cavitation, directly causing water molecule disintegration and resulting in the formation of hydroxylradicals, the most potent of the reactive oxygen species. Considering the oxidative insult to endothelial cells caused by free radicals, their presence in the anterior chamber may represent one of the most harmful factors during these procedures. Indeed, some researchers have recently started to evaluate PEA from the perspective of oxidative stress. Conversely, the major ingredient in ophthalmic viscosurgical devices (OVDs), which are indispensable for maintaining the anterior chamber in PEA surgery, is sodium hyaluronate, a known free radical scavenger. OVDs can thus be expected to provide some anti-free radical effect during PEA procedures. In addition, since commercially available OVDs display different properties regarding retention in the anterior chamber during PEA, the anti-free radical effect of OVDs is likely to depend on behavior during irrigation and aspiration. The present study followed standard PEA procedures in an eye model and measured hydroxylradicals in the anterior chamber using electron spin resonance. The kinetics of free radical intensity and effects of several OVDs during clinical PEA were also demonstrated. These studies may be of significance in re-evaluating OVDs as a chemical protectant for corneal endothelium, since the OVD has thus far only been regarded as a physical barrier. In addition, many reports about corneal endothelium damage during PEA have been published, but objective evaluation of various damaging factors has been difficult. The present assay of free radicals in a simulation of clinical PEA offers the first method to quantitatively assess stress on the corneal endothelium.

A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics.

PubMed

Dautriche, Cula N; Tian, Yangzi; Xie, Yubing; Sharfstein, Susan T

2015-09-21

Among ocular pathologies, glaucoma is the second leading cause of progressive vision loss, expected to affect 80 million people worldwide by 2020. A primary cause of glaucoma appears to be damage to the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm's canal, regulate and maintain homeostatic responses to intraocular pressure. In glaucoma, filtration of aqueous humor into the Schlemm's canal is hindered, leading to an increase in intraocular pressure and subsequent damage to the optic nerve, with progressive vision loss. The Schlemm's canal encompasses a unique endothelium. Recent advances in culturing and manipulating Schlemm's canal cells have elucidated several aspects of their physiology, including ultrastructure, cell-specific marker expression, and biomechanical properties. This review highlights these advances and discusses implications for engineering a 3D, biomimetic, in vitro model of the Schlemm's canal endothelium to further advance glaucoma research, including drug testing and gene therapy screening.

Systematic review: the effects of carbonated beverages on gastro-oesophageal reflux disease.

PubMed

Johnson, T; Gerson, L; Hershcovici, T; Stave, C; Fass, R

2010-03-01

Carbonated beverages have unique properties that may potentially exacerbate gastro-oesophageal reflux disease (GERD), such as high acidity and carbonation. Cessation of carbonated beverage consumption is commonly recommended as part of lifestyle modifications for patients with GERD. To evaluate the relationship of carbonated beverages with oesophageal pH, oesophageal motility, oesophageal damage, GERD symptoms and GERD complications. A systematic review. Carbonated beverage consumption results in a very short decline in intra-oesophageal pH. In addition, carbonated beverages may lead to a transient reduction in lower oesophageal sphincter basal pressure. There is no evidence that carbonated beverages directly cause oesophageal damage. Carbonated beverages have not been consistently shown to cause GERD-related symptoms. Furthermore, there is no evidence that these popular drinks lead to GERD complications or oesophageal cancer. Based on the currently available literature, it appears that there is no direct evidence that carbonated beverages promote or exacerbate GERD.

General characteristics of causes of urban flood damage and flood forecasting/warning system in Seoul, Korea Young-Il Moon1, 2, Jong-Suk Kim1, 2 1 Department of Civil Engineering, University of Seoul, Seoul 130-743, South Korea 2 Urban Flood Research Inst

NASA Astrophysics Data System (ADS)

Moon, Young-Il; Kim, Jong-Suk

2015-04-01

Due to rapid urbanization and climate change, the frequency of concentrated heavy rainfall has increased, causing urban floods that result in casualties and property damage. As a consequence of natural disasters that occur annually, the cost of damage in Korea is estimated to be over two billion US dollars per year. As interest in natural disasters increase, demands for a safe national territory and efficient emergency plans are on the rise. In addition to this, as a part of the measures to cope with the increase of inland flood damage, it is necessary to build a systematic city flood prevention system that uses technology to quantify flood risk as well as flood forecast based on both rivers and inland water bodies. Despite the investment and efforts to prevent landside flood damage, research and studies of landside-river combined hydro-system is at its initial stage in Korea. Therefore, the purpose of this research introduces the causes of flood damage in Seoul and shows a flood forecasting and warning system in urban streams of Seoul. This urban flood forecasting and warning system conducts prediction on flash rain or short-term rainfall by using radar and satellite information and performs prompt and accurate prediction on the inland flooded area and also supports synthetic decision-making for prevention through real-time monitoring. Although we cannot prevent damage from typhoons or localized heavy rain, we can minimize that damage with accurate and timely forecast and a prevention system. To this end, we developed a flood forecasting and warning system, so in case of an emergency there is enough time for evacuation and disaster control. Keywords: urban flooding, flood risk, inland-river system, Korea Acknowledgments This research was supported by a grant (13AWMP-B066744-01) from Advanced Water Management Research Program (AWMP) funded by Ministry of Land, Infrastructure and Transport of Korean government.

Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and prevents UVB-induced oxidative stress and DNA damage in a skin cell model.

PubMed

Pérez-Sánchez, Almudena; Barrajón-Catalán, Enrique; Herranz-López, María; Castillo, Julián; Micol, Vicente

2016-11-01

Solar ultraviolet (UV) radiation is one of the main causes of a variety of cutaneous disorders, including photoaging and skin cancer. Its UVB component (280-315nm) leads to oxidative stress and causes inflammation, DNA damage, p53 induction and lipid and protein oxidation. Recently, an increase in the use of plant polyphenols with antioxidant and anti-inflammatory properties has emerged to protect human skin against the deleterious effects of sunlight. This study evaluates the protective effects of lemon balm extract (LBE) (Melissa Officinalis, L) and its main phenolic compound rosmarinic acid (RA) against UVB-induced damage in human keratinocytes. The LBE composition was determined by HPLC analysis coupled to photodiode array detector and ion trap mass spectrometry with electrospray ionization (HPLC-DAD-ESI-IT-MS/MS). Cell survival, ROS generation and DNA damage were determined upon UVB irradiation in the presence of LBE. The melanogenic capacity of LBE was also determined. RA and salvianolic acid derivatives were the major compounds, but caffeic acid and luteolin glucuronide were also found in LBE. LBE and RA significantly increased the survival of human keratinocytes upon UVB radiation, but LBE showed a stronger effect. LBE significantly decreased UVB-induced intracellular ROS production. Moreover, LBE reduced UV-induced DNA damage and the DNA damage response (DDR), which were measured as DNA strand breaks in the comet assay and histone H2AX activation, respectively. Finally, LBE promoted melanogenesis in the cell model. These results suggest that LBE may be considered as a candidate for the development of oral/topical photoprotective ingredients against UVB-induced skin damage. Copyright © 2016 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

A brush fire forensic case.

PubMed

Rella, R; Sturaro, A; Parvoli, G; Ferrara, D; Casellato, U; Vadalà, G

2005-01-01

In Italy, every summer forest fires attract public attention due to the number of victims, the intensity of the fires, the areas devastated, the environmental damage and the loss of property. Excluding some fires by natural causes, other causes are related to the social, economic, and productive profile of the territory. The erroneous expectation is that wooded areas destroyed by fire can then be used for private interests. Often, a fire, started to clear a small area, can completely change the expected result, producing disaster, loss of property, destruction of entire forests and resident fauna, and kill innocent people. In this case report, the reconstruction of an arson scene, the analytical techniques and the results obtained are illustrated in this paper, with the aim of sharing with other research laboratories the current knowledge on forest fire.

Natural Hazard Public Policy Implications of the May 12, 2008 M7.9 Wenchuan Earthquake, Sichuan, China

NASA Astrophysics Data System (ADS)

Cydzik, K.; Hamilton, D.; Stenner, H. D.; Cattarossi, A.; Shrestha, P. L.

2009-12-01

The May 12, 2008 M7.9 Wenchuan Earthquake in Sichuan Province, China killed almost 90,000 people and affected a population of over 45.5 million throughout western China. Shaking caused the destruction of five million buildings, many of them homes and schools, and damaged 21 million other structures, inflicting devastating impacts to communities. Landslides, a secondary effect of the shaking, caused much of the devastation. Debris flows buried schools and homes, rock falls crushed cars, and rockslides, landslides, and rock avalanches blocked streams and rivers creating massive, unstable landslide dams, which formed “quake lakes” upstream of the blockages. Impassable roads made emergency access slow and extremely difficult. Collapses of buildings and structures large and small took the lives of many. Damage to infrastructure impaired communication, cut off water supplies and electricity, and put authorities on high alert as the integrity of large engineered dams were reviewed. During our field reconnaissance three months after the disaster, evidence of the extent of the tragedy was undeniably apparent. Observing the damage throughout Sichuan reminded us that earthquakes in the United States and throughout the world routinely cause widespread damage and destruction to lives, property, and infrastructure. The focus of this poster is to present observations and findings based on our field reconnaissance regarding the scale of earthquake destruction with respect to slope failures, landslide dams, damage to infrastructure (e.g., schools, engineered dams, buildings, roads, rail lines, and water resources facilities), human habitation within the region, and the mitigation and response effort to this catastrophe. This is presented in the context of the policy measures that could be developed to reduce risks of similar catastrophes. The rapid response of the Chinese government and the mobilization of the Chinese People’s Liberation Army to help the communities affected by the earthquake have allowed survivors to begin rebuilding their lives. However, the long-term impact of the earthquake continues to make headlines. Post-earthquake landslides and debris flows initiated by storm events have continued to impart devastation on the region. Events such as the Wenchuan Earthquake provide unique opportunities for engineers, scientists, and policy makers to collaborate for purposes of exploring the details of natural hazards and developing sound policies to protect lives and property in the future.

Vitamin A and C compounds permitted in supplements differ in their abilities to affect cell viability, DNA and the DNA nucleoside deoxyguanosine.

PubMed

Bergström, Therese; Bergman, Jan; Möller, Lennart

2011-11-01

In accordance with the European Parliament and Council's directive, vitamin A and C supplements can include any of four (vitamin A) or five (vitamin C) specified compounds. This study focuses on these compounds and compares their abilities to affect the DNA and viability of cells in culture, but also their potencies to chemically oxidise the DNA nucleoside deoxyguanosine (dG). To study the vitamins' strict chemical oxidation potencies, dG was exposed to vitamin solution and the amount of the oxidation product 8'-hydroxydeoxyguanosine (8-oxodG) formed was estimated using a high-performance liquid chromatography system with electrochemical and ultraviolet detection. The vitamin's ability to cause DNA damage to promyelocytic leukaemia cells (HL-60), as detected by strand breaks, alkaline labile sites and formamido pyrimidine DNA glycosylase (FPG)-sensitive sites was, after vitamin exposure, measured using the comet assay and cytotoxicity was estimated using trypan blue staining. The results highlight that vitamin A and C compounds found in supplements do have different properties, chemically as well as in a cellular system. Among the vitamin C compounds, ascorbic acid, sodium ascorbate and calcium ascorbate stood out causing both oxidation to dG and cytotoxicity to cells. The vitamin A compounds retinol, retinyl acetate and retinal (a breakdown product found in vivo) caused oxidation of dG, while retinal was the only compound causing cytotoxicity, giving rise to an almost complete cell death. β-carotene caused, as the only vitamin compound, a small increase in FPG-sensitive sites. It is concluded that even though the compounds are found under the same name (vitamin A or C), they do have different properties linked to oxidation, cytotoxicity and DNA damage.

Protective effect of pomegranate derived products on UVB-mediated damage in human reconstituted skin

PubMed Central

Afaq, Farrukh; Zaid, Mohammad Abu; Khan, Naghma; Dreher, Mark; Mukhtar, Hasan

2010-01-01

Solar ultraviolet (UV) radiation, particularly its UVB (290-320 nm) component, is the primary cause of many adverse biological effects including photoaging and skin cancer. UVB radiation causes DNA damage, protein oxidation and induces matrix metalloproteinases (MMPs). Photochemoprevention via the use of botanical antioxidants in affording protection to human skin against UVB damage is receiving increasing attention. Pomegranate, from the tree Punica granatum contains anthocyanins and hydrolyzable tannins and possesses strong anti-oxidant and anti-tumor promoting properties. In this study, we determined the effect of pomegranate derived products POMx juice, POMx extract and pomegranate oil (POMo) against UVB-mediated damage using reconstituted human skin (EpiDerm™ FT-200). EpiDerm was treated with POMx juice (1-2 μl/0.1 ml/well), POMx extract (5-10 μg/0.1 ml/well), and POMo (1-2 μl/0.1 ml/well) for 1 h prior to UVB (60 mJ/cm2) irradiation and was harvested 12 h post-UVB to assess protein oxidation, markers of DNA damage and photoaging by western blot analysis and immunohistochemistry. Pretreatment of Epiderm with pomegranate derived products resulted in inhibition of UVB-induced (i) cyclobutane pyrimidine dimers, (ii) 8-dihydro-2′-deoxyguanosine, (iii) protein oxidation, and (iv) PCNA protein expression. We also found that pretreatment of Epiderm with pomegranate derived products resulted in inhibition of UVB-induced (i) collagenase (MMP-1), (ii) gelatinase (MMP-2, MMP-9), (iii) stromelysin (MMP-3), (iv) marilysin (MMP-7), (v) elastase (MMP-12), and (vi) tropoelastin. Gelatin zymography revealed that pomegranate derived products inhibited UVB-induced MMP-2 and MMP-9 activities. Pomegranate derived products also caused a decrease in UVB-induced protein expression of c-Fos and phosphorylation of c-Jun. Collectively, these results suggest that all three pomegranate derived products may be useful against UVB-induced damage to human skin. PMID:19320737

The frequency and distribution of recent landslides in three montane tropical regions of Puerto Rico

Treesearch

Matthew C. Larsen; Angel J. Torres-Sanchez

1998-01-01

Landslides are common in steep mountainous areas of Puerto Rico where mean annual rainfall and the frequency of intense storms are high. Each year, landslides cause extensive damage to property and occasionally result in loss of life. Average population density is high, 422 peoplerkm2, and is increasing. This increase in population density is accompanied by growing...

The Tornado Hazard in Southern New England: History, Characteristics, Student and Teacher Perceptions

ERIC Educational Resources Information Center

Lewis, Thomas R.

2006-01-01

People generally do not perceive New England to be tornado-prone. Yet, there is a long history of such storms in the six states going back to the late seventeenth century. Usually, New England tornadoes are small and short-lived; even so, some have caused many deaths and much property damage. There is a greater probability for a person to be…

Susceptibility of central hardwood trees to stem breakage due to ice glazing

Treesearch

KaDonna C. Randolph

2014-01-01

During January 26-28, 2009, a winter storm dropped a mix of rain, ice, and snow from Texas across the Ohio River Valley and into New England. The storm caused multiple fatalities and millions of dollars of property damage and was called "the biggest natural disaster in modern Kentucky history" (Brammer and Funk 2009: 13). The storm disturbed an estimated 2.4...

Modeling Creep-Fatigue-Environment Interactions in Steam Turbine Rotor Materials for Advanced Ultra-supercritical Coal Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Chen

2014-04-01

The goal of this project is to model creep-fatigue-environment interactions in steam turbine rotor materials for advanced ultra-supercritical (A-USC) coal power Alloy 282 plants, to develop and demonstrate computational algorithms for alloy property predictions, and to determine and model key mechanisms that contribute to the damages caused by creep-fatigue-environment interactions.

Using remote sensing to predict earthquake impacts

NASA Astrophysics Data System (ADS)

Fylaktos, Asimakis; Yfantidou, Anastasia

2017-09-01

Natural hazards like earthquakes can result to enormous property damage, and human casualties in mountainous areas. Italy has always been exposed to numerous earthquakes, mostly concentrated in central and southern regions. Last year, two seismic events near Norcia (central Italy) have occurred, which led to substantial loss of life and extensive damage to properties, infrastructure and cultural heritage. This research utilizes remote sensing products and GIS software, to provide a database of information. We used both SAR images of Sentinel 1A and optical imagery of Landsat 8 to examine the differences of topography with the aid of the multi temporal monitoring technique. This technique suits for the observation of any surface deformation. This database is a cluster of information regarding the consequences of the earthquakes in groups, such as property and infrastructure damage, regional rifts, cultivation loss, landslides and surface deformations amongst others, all mapped on GIS software. Relevant organizations can implement these data in order to calculate the financial impact of these types of earthquakes. In the future, we can enrich this database including more regions and enhance the variety of its applications. For instance, we could predict the future impacts of any type of earthquake in several areas, and design a preliminarily model of emergency for immediate evacuation and quick recovery response. It is important to know how the surface moves, in particular geographical regions like Italy, Cyprus and Greece, where earthquakes are so frequent. We are not able to predict earthquakes, but using data from this research, we may assess the damage that could be caused in the future.

Optimal filter design with progressive genetic algorithm for local damage detection in rolling bearings

NASA Astrophysics Data System (ADS)

Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw

2018-03-01

Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.

Studies on transmitted beam modulation effect from laser induced damage on fused silica optics.

PubMed

Zheng, Yi; Ma, Ping; Li, Haibo; Liu, Zhichao; Chen, Songlin

2013-07-15

UV laser induced damage (LID) on exit surface of fused silica could cause modulation effect to transmitted beam and further influence downstream propagation properties. This paper presents our experimental and analytical studies on this topic. In experiment, a series of measurement instruments are applied, including beam profiler, interferometer, microscope, and optical coherent tomography (OCT). Creating and characterizing of LID on fused silica sample have been implemented. Morphological features are studied based on their particular modulation effects on transmitted beam. In theoretical investigation, analytical modeling and numerical simulation are performed. Modulation effects from amplitude, phase, and size factors are analyzed respectively. Furthermore, we have novelly designed a simplified polygon model to simulate actual damage site with multiform modulation features, and the simulation results demonstrate that the modeling is usable and representative.

Distribution of intensity for the Westmorland, California, earthquake of April 26, 1981

USGS Publications Warehouse

Barnhard, L.M.; Thenhaus, P.C.; Algermissen, Sylvester Theodore

1982-01-01

The maximum Modified Mercalli intensity of the April 26, 1981 earthquake located 5 km northwest of Westmorland, California is VII. Twelve buildings in Westmorland were severely damaged with an additional 30 sustaining minor damage. Two brick parapets fell in Calipatria, 14 km northeast of Westmorland and 10 km from the earthquake epicenter. Significant damage in rural areas was restricted to unreinforced, concrete-lined irrigation canals. Liquefaction effects and ground slumping were widespread in rural areas and were the primary causes of road cracking. Preliminary local government estimates of property loss range from one to three million dollars (Imperial Valley Press, 1981). The earthquake was felt over an area of approximately 160,000 km2; about the same felt area of the October 15, 1979 (Reagor and others, 1980), and May 18, 1940 (Ulrich, 1941) Imperial Valley earthquakes.

The 1964 Great Alaska Earthquake and tsunamis: a modern perspective and enduring legacies

USGS Publications Warehouse

Brocher, Thomas M.; Filson, John R.; Fuis, Gary S.; Haeussler, Peter J.; Holzer, Thomas L.; Plafker, George; Blair, J. Luke

2014-01-01

The magnitude 9.2 Great Alaska Earthquake that struck south-central Alaska at 5:36 p.m. on Friday, March 27, 1964, is the largest recorded earthquake in U.S. history and the second-largest earthquake recorded with modern instruments. The earthquake was felt throughout most of mainland Alaska, as far west as Dutch Harbor in the Aleutian Islands some 480 miles away, and at Seattle, Washington, more than 1,200 miles to the southeast of the fault rupture, where the Space Needle swayed perceptibly. The earthquake caused rivers, lakes, and other waterways to slosh as far away as the coasts of Texas and Louisiana. Water-level recorders in 47 states—the entire Nation except for Connecticut, Delaware, and Rhode Island— registered the earthquake. It was so large that it caused the entire Earth to ring like a bell: vibrations that were among the first of their kind ever recorded by modern instruments. The Great Alaska Earthquake spawned thousands of lesser aftershocks and hundreds of damaging landslides, submarine slumps, and other ground failures. Alaska’s largest city, Anchorage, located west of the fault rupture, sustained heavy property damage. Tsunamis produced by the earthquake resulted in deaths and damage as far away as Oregon and California. Altogether the earthquake and subsequent tsunamis caused 129 fatalities and an estimated $2.3 billion in property losses (in 2013 dollars). Most of the population of Alaska and its major transportation routes, ports, and infrastructure lie near the eastern segment of the Aleutian Trench that ruptured in the 1964 earthquake. Although the Great Alaska Earthquake was tragic because of the loss of life and property, it provided a wealth of data about subductionzone earthquakes and the hazards they pose. The leap in scientific understanding that followed the 1964 earthquake has led to major breakthroughs in earth science research worldwide over the past half century. This fact sheet commemorates Great Alaska Earthquake and examines the advances in knowledge and technology that have helped to improve earthquake preparation and response both in Alaska and around the world.

Mechanical properties of cocoons constructed consecutively by a single silkworm caterpillar, Bombyx mori

NASA Astrophysics Data System (ADS)

Huang, S. Q.; Zhao, H. P.; Feng, X. Q.; Cui, W.; Lin, Z.; Xu, M. Q.

2008-04-01

Most animals have the ability to adapt, to some extends and in different ways, the variation or disturbance of environment. In our experiments, we forced a silkworm caterpillar to spin two, three or four thin cocoons by taking it out from the cocoon being constructed. The mechanical properties of these cocoons were studied by static tensile tests and dynamic mechanical thermal analysis. Though external disturbances may cause the decrease in the total weight of silk spun by the silkworm, a gradual enhancement was interestingly found in the mechanical properties of these thin cocoons. Scanning electron microscopy observations of the fractured specimens of the cocoons showed that there exist several different energy dissipation mechanisms occurred simultaneously at macro-, meso-, and micro-scales, yielding a superior capacity of cocoons to adsorb the energy of possible attacks from the outside and to protect efficiently its pupa against damage. Through evolution of millions of years, therefore, the silkworm Bombyx mori seems to have gained the ability to adapt external disturbances and to redesign a new cocoon with optimized protective function when its first cocoon has been damaged for some reasons.

Effect of high energy X-ray irradiation on the nano-mechanical properties of human enamel and dentine.

PubMed

Liang, Xue; Zhang, Jing Yang; Cheng, Iek Ka; Li, Ji Yao

2016-01-01

Radiotherapy for malignancies in the head and neck can cause common complications that can result in tooth damage that are also known as radiation caries. The aim of this study was to examine damage to the surface topography and calculate changes in friction behavior and the nano-mechanical properties (elastic modulus, nanohardness and friction coefficient) of enamel and dentine from extracted human third molars caused by exposure to radiation. Enamel and dentine samples from 50 human third molars were randomly assigned to four test groups or a control group. The test groups were exposed to high energy X-rays at 2 Gy/day, 5 days/week for 5 days (10 Gy group), 15 days (30 Gy group), 25 days (50 Gy group), 35 days (70 Gy group); the control group was not exposed. The nanohardness, elastic modulus, and friction coefficient were analyzed using a Hysitron Triboindenter. The nano-mechanical properties of both enamel and dentine showed significant dose-response relationships. The nanohardness and elastic modulus were most variable between 30-50 Gy, while the friction coefficient was most variable between 0-10 Gy for dentine and 30-50 Gy for enamel. After exposure to X-rays, the fracture resistance of the teeth clearly decreased (rapidly increasing friction coefficient with increasing doses under the same load), and they were more fragile. These nano-mechanical changes in dental hard tissue may increase the susceptibility to caries. Radiotherapy caused nano-mechanical changes in dentine and enamel that were dose related. The key doses were 30-50 Gy and the key time points occurred during the 15th-25th days of treatment, which is when application of measures to prevent radiation caries should be considered.

A prediction and damage assessment model for snowmelt flood events in middle and high latitudes Region

NASA Astrophysics Data System (ADS)

Qiao, C.; Huang, Q.; Chen, T.; Zhang, X.

2017-12-01

In the context of global warming, the snowmelt flood events in the mountainous area of the middle and high latitudes are increasingly frequent and create severe casualties and property damages. Carrying out the prediction and risk assessment of the snowmelt flood is of great importance in the water resources management, the flood warning and prevention. Based on the remote sensing and GIS techniques, the relationships of the variables influencing the snowmelt flood such as the snow area, the snow depth, the air temperature, the precipitation, the land topography and land covers are analyzed and a prediction and damage assessment model for snowmelt floods is developed. This model analyzes and predicts the flood submerging area, flood depth, flood grade, and the damages of different underlying surfaces in the study area in a given time period based on the estimation of snowmelt amount, the snowmelt runoff, the direction and velocity of the flood. Then it was used to predict a snowmelt flood event in the Ertis River Basin in northern Xinjiang, China, during March and June, 2005 and to assess its damages including the damages of roads, transmission lines, settlements caused by the floods and the possible landslides using the hydrological and meteorological data, snow parameter data, DEM data and land use data. A comparison was made between the prediction results from this model and observation data including the flood measurement and its disaster loss data, which suggests that this model performs well in predicting the strength and impact area of snowmelt flood and its damage assessment. This model will be helpful for the prediction and damage assessment of snowmelt flood events in the mountainous area in the middle and high latitudes in spring, which has great social and economic significance because it provides a relatively reliable method for snowmelt flood prediction and reduces the possible damages caused by snowmelt floods.

Prophylaxis with Bacopa monnieri attenuates acrylamide induced neurotoxicity and oxidative damage via elevated antioxidant function.

PubMed

Shinomol, George Kunnel; Raghunath, Narayanareddy; Bharath, Muchukunte Mukunda Srinivas; Muralidhara

2013-03-01

Acrylamide (ACR) is a water-soluble, vinyl monomer that has multiple chemical and industrial applications. Exposure to ACR causes neuropathy and associated neurological defects including gait abnormalities and skeletal muscle weakness, due to impaired neurotransmitter release and eventual neurodegeneration. Using in vivo and in vitro models, we examined whether oxidative events are involved in ACR-mediated neurotoxicity and whether these could be prevented by natural plant extracts. Administration (i.p.) of ACR in mice (40 mg/kg bw/ d for 5d) induced significant oxidative damage in the brain cortex and liver as evidenced by elevated lipid peroxidation, reactive oxygen species and protein carbonyls. This was associated with lowered antioxidant activities including antioxidant enzymes (catalase, glutathione-s-transferase) and reduced glutathione (GSH) compared to untreated controls. Similarly, exposure of N27 neuronal cells in culture to ACR (1-5 mM) caused dose-dependent neuronal death and lowered GSH. Interestingly, dietary supplementation with the leaf powder of Bacopa monnieri (BM) (which possesses neuroprotective properties and nootropic activity) in mice for 30 days offered significant protection against ACR toxicity and oxidative damage in vivo. Similarly, pretreatment with BM protected the N27 cells against ACR-induced cell death and associated oxidative damage. Co-treatment and pre-treatment of Drosophila melanogaster with BM extract protected against ACR-induced locomotor dysfunction and GSH depletion. We infer that BM displays prophylactic effects against ACR induced oxidative damage and neurotoxicity with potential therapeutic application in human pathology associated with neuropathy.

Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries

PubMed Central

Manshian, Bella B.; Soenen, Stefaan J.; Brown, Andy; Hondow, Nicole; Wills, John; Jenkins, Gareth J. S.; Doak, Shareen H.

2016-01-01

Quantum dots (QD) have unique electronic and optical properties promoting biotechnological advances. However, our understanding of the toxicological structure–activity relationships remains limited. This study aimed to determine the biological impact of varying nanomaterial surface chemistry by assessing the interaction of QD with either a negative (carboxyl), neutral (hexadecylamine; HDA) or positive (amine) polymer coating with human lymphoblastoid TK6 cells. Following QD physico-chemical characterisation, cellular uptake was quantified by optical and electron microscopy. Cytotoxicity was evaluated and genotoxicity was characterised using the micronucleus assay (gross chromosomal damage) and the HPRT forward mutation assay (point mutagenicity). Cellular damage mechanisms were also explored, focusing on oxidative stress and mitochondrial damage. Cell uptake, cytotoxicity and genotoxicity were found to be dependent on QD surface chemistry. Carboxyl-QD demonstrated the smallest agglomerate size and greatest cellular uptake, which correlated with a dose dependent increase in cytotoxicity and genotoxicity. Amine-QD induced minimal cellular damage, while HDA-QD promoted substantial induction of cell death and genotoxicity. However, HDA-QD were not internalised by the cells and the damage they caused was most likely due to free cadmium release caused by QD dissolution. Oxidative stress and induced mitochondrial reactive oxygen species were only partially associated with cytotoxicity and genotoxicity induced by the QD, hence were not the only mechanisms of importance. Colloidal stability, nanoparticle (NP) surface chemistry, cellular uptake levels and the intrinsic characteristics of the NPs are therefore critical parameters impacting genotoxicity induced by QD. PMID:26275419

A new survey tool to assess pluvial damage to residential buildings

NASA Astrophysics Data System (ADS)

Rözer, Viktor; Spekkers, Matthieu; ten Veldhuis, Marie-Claire; Kreibich, Heidi

2017-04-01

Pluvial floods have caused severe damage to urban dwellings in Europe and elsewhere in recent years. These type of flood events are caused by storm events with exceptionally high rainfall rates, which lead to inundation of streets and buildings and are commonly associated with a failure of the urban drainage system. Therefore, pluvial floods often happen with little warning and in areas that are not obviously prone to flooding. With a predicted increase in extreme weather events as well as an ongoing urbanization, pluvial flood damage is expected to increase in the future. So far little research was done on the adverse consequences of pluvial floods, as empirical damage data of pluvial flooding is scarce. Therefore, a newly developed survey tool to assess pluvial flood damage as well as the results of a comparison between two international pluvial flood case studies are presented. The questionnaire used in the two study areas was developed with the aim to create a harmonized transnational pluvial flood damage survey that can potentially be extended to other European countries. New indicator variables have been developed to account for different national and regional standards in building structure, early warning, socio-economic data and recovery. The surveys comprise interviews with 510 households in the Münster area (Germany) and 349 households in Amsterdam (the Netherlands), which were affected by the heavy rainfall events on July 28 2014. The respondents were asked more than 80 questions about the damage to their building structure and contents, as well as on topics such as early warning, emergency and precautionary measures, building properties and hazard characteristics. A comparison of the two surveys revealed strong similarities concerning damage reducing effects and the popularity of precautionary measures, besides significant differences between the mean water levels inside the house as well as the median of the building structure and content damage. A comparison between the relative damage contributions for different entry points of water into the house indicates an effect of regional distinctions in building topology on the total damage. The results of this comparison give important insights for the development and transferability of pluvial flood damage models.

Assessment of the Antioxidant Activity of Silybum marianum Seed Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

PubMed Central

Serçe, Aynur; Toptancı, Bircan Çeken; Tanrıkut, Sevil Emen; Altaş, Sevcan; Kızıl, Göksel; Kızıl, Süleyman

2016-01-01

Summary Antioxidant properties of ethanol extract of Silybum marianum (milk thistle) seeds was investigated. We have also investigated the protein damage activated by oxidative Fenton reaction and its prevention by Silybum marianum seed extract. Antioxidant potential of Silybum marianum seed ethanol extract was measured using different in vitro methods, such as lipid peroxidation, 1,1–diphenyl–2–picrylhydrazyl (DPPH) and ferric reducing power assays. The extract significantly decreased DNA damage caused by hydroxyl radicals. Protein damage induced by hydroxyl radicals was also efficiently inhibited, which was confirmed by the presence of protein damage markers, such as protein carbonyl formation and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS–PAGE). The present study shows that milk thistle seeds have good DPPH free radical scavenging activity and can prevent lipid peroxidation. Therefore, Silybum marianum can be used as potentially rich source of antioxidants and food preservatives. The results suggest that the seeds may have potential beneficial health effects providing opportunities to develop value-added products. PMID:28115903

Assessment of the Antioxidant Activity of Silybum marianum Seed Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation.

PubMed

Serçe, Aynur; Toptancı, Bircan Çeken; Tanrıkut, Sevil Emen; Altaş, Sevcan; Kızıl, Göksel; Kızıl, Süleyman; Kızıl, Murat

2016-12-01

Antioxidant properties of ethanol extract of Silybum marianum (milk thistle) seeds was investigated. We have also investigated the protein damage activated by oxidative Fenton reaction and its prevention by Silybum marianum seed extract. Antioxidant potential of Silybum marianum seed ethanol extract was measured using different in vitro methods, such as lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing power assays. The extract significantly decreased DNA damage caused by hydroxyl radicals. Protein damage induced by hydroxyl radicals was also efficiently inhibited, which was confirmed by the presence of protein damage markers, such as protein carbonyl formation and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The present study shows that milk thistle seeds have good DPPH free radical scavenging activity and can prevent lipid peroxidation. Therefore, Silybum marianum can be used as potentially rich source of antioxidants and food preservatives. The results suggest that the seeds may have potential beneficial health effects providing opportunities to develop value-added products.

Simulation of rainfall-runoff for major flash flood events in Karachi

NASA Astrophysics Data System (ADS)

Zafar, Sumaira

2016-07-01

Metropolitan city Karachi has strategic importance for Pakistan. With the each passing decade the city is facing urban sprawl and rapid population growth. These rapid changes directly affecting the natural resources of city including its drainage pattern. Karachi has three major cities Malir River with the catchment area of 2252 sqkm and Lyari River has catchment area about 470.4 sqkm. These are non-perennial rivers and active only during storms. Change of natural surfaces into hard pavement causing an increase in rainfall-runoff response. Curve Number is increased which is now causing flash floods in the urban locality of Karachi. There is only one gauge installed on the upstream of the river but there no record for the discharge. Only one gauge located at the upstream is not sufficient for discharge measurements. To simulate the maximum discharge of Malir River rainfall (1985 to 2014) data were collected from Pakistan meteorological department. Major rainfall events use to simulate the rainfall runoff. Maximum rainfall-runoff response was recorded in during 1994, 2007 and 2013. This runoff causes damages and inundation in floodplain areas of Karachi. These flash flooding events not only damage the property but also cause losses of lives

Prevention of DNA damage and anticarcinogenic activity of Activia® in a preclinical model.

PubMed

Limeiras, S M A; Ogo, F M; Genez, L A L; Carreira, C M; Oliveira, E J T; Pessatto, L R; Neves, S C; Pesarini, J R; Schweich, L C; Silva, R A; Cantero, W B; Antoniolli-Silva, A C M B; Oliveira, R J

2017-03-22

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

Correlation of Radiation Dosage With Mechanical Properties of Thin Films

NASA Technical Reports Server (NTRS)

Newton, R. L.

2003-01-01

The objective of this investigation was to examine the relationship between irradiation level (proton dose), microstructure, and stress levels in chemical vapor deposited diamond and polysilicon film using crosssectioned specimens. However, the emphasis was placed on the diamond specimen because diamond holds much promise for use in advanced technologies. The use of protons allows not only the study of the charged particle that may cause the most microstructural damage in Earth-orbit microelectromechanical systems (MEMS) devices, but also allows the study of relatively deeply buried damage inside the diamond material. Using protons allows these studies without having to resort to megaelectronvolt implant energies that may create extensive damage due to the high energy that is needed for the implantation process. Since 1 MEMS devices operating in space will not have an opportunity to reverse radiation damage via annealing, only nonannealed specimens were investigated. The following three high spatial resolution techniques were used to examine these relationships: (I) Scanning electron microscopy, (2) micro-Raman spectroscopy, and (3) micro x-ray diffraction.

3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter

PubMed Central

Anneken, John H.; Angoa-Pérez, Mariana; Kuhn, Donald M.

2016-01-01

Methylone, 3,4-methylenedioxypyrovalerone (MDPV), and mephedrone are psychoactive ingredients of ‘bath salts’ and their abuse represents a growing public health care concern. These drugs are cathinone derivatives and are classified chemically as β-ketoamphetamines. Because of their close structural similarity to the amphetamines, methylone, MDPV, and mephedrone share most of their pharmacological, neurochemical, and behavioral properties. One point of divergence in their actions is the ability to cause damage to the CNS. Unlike methamphetamine, the β-ketoamphetamines do not damage dopamine (DA) nerve endings. However, mephedrone has been shown to significantly accentuate methamphetamine neurotoxicity. Bath salt formulations contain numerous different psychoactive ingredients, and individuals who abuse bath salts also coabuse other illicit drugs. Therefore, we have evaluated the effects of methylone, MDPV, mephedrone, and methamphetamine on DA nerve endings. The β-ketoamphetamines alone or in all possible two-drug combinations do not result in damage to DA nerve endings but do cause hyperthermia. MDPV completely protects against the neurotoxic effects of methamphetamine while methylone accentuates it. Neither MDPV nor methylone attenuates the hyperthermic effects of methamphetamine. The potent neuroprotective effects of MDPV extend to amphetamine-, 3,4-methylenedioxymethamphetamine-, and MPTP-induced neurotoxicity. These results indicate that β-ketoamphetamine drugs that are non-substrate blockers of the DA transporter (i.e., MDPV) protect against methamphetamine neurotoxicity, whereas those that are substrates for uptake by the DA transporter and which cause DA release (i.e., methylone, mephedrone) accentuate neurotoxicity. PMID:25626880

Quantitative diagnosis and prognosis framework for concrete degradation due to alkali-silica reaction

NASA Astrophysics Data System (ADS)

Mahadevan, Sankaran; Neal, Kyle; Nath, Paromita; Bao, Yanqing; Cai, Guowei; Orme, Peter; Adams, Douglas; Agarwal, Vivek

2017-02-01

This research is seeking to develop a probabilistic framework for health diagnosis and prognosis of aging concrete structures in nuclear power plants that are subjected to physical, chemical, environment, and mechanical degradation. The proposed framework consists of four elements: monitoring, data analytics, uncertainty quantification, and prognosis. The current work focuses on degradation caused by ASR (alkali-silica reaction). Controlled concrete specimens with reactive aggregate are prepared to develop accelerated ASR degradation. Different monitoring techniques — infrared thermography, digital image correlation (DIC), mechanical deformation measurements, nonlinear impact resonance acoustic spectroscopy (NIRAS), and vibro-acoustic modulation (VAM) — are studied for ASR diagnosis of the specimens. Both DIC and mechanical measurements record the specimen deformation caused by ASR gel expansion. Thermography is used to compare the thermal response of pristine and damaged concrete specimens and generate a 2-D map of the damage (i.e., ASR gel and cracked area), thus facilitating localization and quantification of damage. NIRAS and VAM are two separate vibration-based techniques that detect nonlinear changes in dynamic properties caused by the damage. The diagnosis results from multiple techniques are then fused using a Bayesian network, which also helps to quantify the uncertainty in the diagnosis. Prognosis of ASR degradation is then performed based on the current state of degradation obtained from diagnosis, by using a coupled thermo-hydro-mechanical-chemical (THMC) model for ASR degradation. This comprehensive approach of monitoring, data analytics, and uncertainty-quantified diagnosis and prognosis will facilitate the development of a quantitative, risk informed framework that will support continuous assessment and risk management of structural health and performance.

Using insurance data to learn more about damages to buildings caused by surface runoff

NASA Astrophysics Data System (ADS)

Bernet, Daniel; Roethlisberger, Veronika; Prasuhn, Volker; Weingartner, Rolf

2015-04-01

In Switzerland, almost forty percent of total insurance loss due to natural hazards in the last two decades was caused by flooding. Those flood damages occurred not only within known inundation zones of water courses. Practitioners expect that roughly half of all flood damages lie outside of known inundation zones. In urban areas such damages may simply be caused by drainage system overload for instance. However, as several case studies show, natural and agricultural land play a major role in surface runoff formation leading to damages in rural and peri-urban areas. Although many damages are caused by surface runoff, the whole process chain including surface runoff formation, propagation through the landscape and damages to buildings is not well understood. Therefore, within the framework of a project, we focus our research on this relevant process. As such flash flood events have a very short response time and occur rather diffusely in the landscape, this process is very difficult to observe directly. Therefore indirect data sources with the potential to indicate spatial and temporal distributions of the process have to be used. For that matter, post-flood damage data may be a profitable source. Namely, insurance companies' damage claim records could provide a good picture about the spatial and temporal distributions of damages caused by surface runoff and, thus, about the process itself. In our research we analyze insurance data records of flood damage claims systematically to infer main drivers and influencing factors of surface runoff causing damages to buildings. To demonstrate the potential and drawbacks of using data from insurance companies in relation to damages caused by surface runoff, a case study is presented. A well-documented event with data from a public as well as a private insurance company is selected. The case study focuses on the differences of the datasets as well as the associated problems and advantages respectively. Furthermore, the analysis of the data, especially the crucial identification of damages caused by surface runoff opposed to damages caused by other processes such as riverine flooding, drainage system surcharges etc. are discussed.

Floods in the United States: Magnitude and frequency

USGS Publications Warehouse

Jarvis, Clarence S.; ,

1936-01-01

From time immemorial floods have transformed beneficent river waters into a menace to humanity. Man's progress toward economic stability has been repeatedly halted or even thrown backward by the interruption of his efforts to make effective use of rivers and of valley lands. This handicap is not imposed by the destructiveness of large rivers alone, or of rivers in widely separated areas, for there are few if any streams, brooks, or rivulets that are not subject to flows beyond their channel capacities. Yet, though man for ages has suffered seriously from recurring floods, he has not been deterred from continuing to extend his activities in areas that are virtually foredoomed to flood damage.Today in the United States serious floods may occur in any section in any year, and even, in some regions, several times a year. Many of these floods leave behind them the tragedy of death and disease and of property irreparably damaged. The aggregate direct property damage caused by floods in this country has been estimated roughly to average $35,000,000 a year. In addition there are serious indirect and intangible losses of great but not precisely calculable magnitude.

Cumulative co-seismic fault damage and feedbacks on earthquake rupture

NASA Astrophysics Data System (ADS)

Mitchell, T. M.; Aben, F. M.; Ostermeijer, G.; Rockwell, T. K.; Doan, M. L.

2017-12-01

The importance of the damage zone in the faulting and earthquake process is widely recognized, but our understanding of how damage zones are created, what their properties are, and how they feed back into the seismic cycle, is remarkably poorly known. Firstly, damaged rocks have reduced elastic moduli, cohesion and yield strength, which can cause attenuation and potentially non-linear wave propagation effects during ruptures. Secondly, damaged fault rocks are generally more permeable than intact rocks, and hence play a key role in the migration of fluids in and around fault zones over the seismic cycle. Finally, the dynamic generation of damage as the earthquake propagates can itself influence the dynamics of rupture propagation, by increasing the amount of energy dissipation, decreasing the rupture velocity, modifying the size of the earthquake, changing the efficiency of weakening mechanisms such as thermal pressurisation of pore fluids, and even generating seismic waves itself . All of these effects imply that a feedback exists between the damage imparted immediately after rupture propagation, at the early stages of fault slip, and the effects of that damage on subsequent ruptures dynamics. In recent years, much debate has been sparked by the identification of so-called `pulverized rocks' described on various crustal-scale faults, a type of intensely damaged fault rock which has undergone minimal shear strain, and the occurrence of which has been linked to damage induced by transient high strain-rate stress perturbations during earthquake rupture. Damage induced by such transient stresses, whether compressional or tensional, likely constitute heterogeneous modulations of the remote stresses that will impart significant changes on the strength, elastic and fluid flow properties of a fault zone immediately after rupture propagation, at the early stage of fault slip. In this contribution, we will demonstrate laboratory and field examples of two dynamic mechanisms that have been proposed for the generation of pulverized rocks; (i) compressive loading by high-frequency stress pulses due to the radiation of seismic waves and (ii) explosive dilation in tension in rocks containing pressurized pore fluids.

Damage Caused by the Rogue Trustee

ERIC Educational Resources Information Center

O'Banion, Terry

2009-01-01

Fifty-nine community college presidents and chancellors in 16 states report on the damage caused by rogue trustees. While the damage to presidents, other trustees, and faculty and staff is alarming, the damage these trustees cause the college suggests that the rogue trustee may be the single most destructive force ever to plague an educational…

The natural product citral can cause significant damage to the hyphal cell walls of Magnaporthe grisea.

PubMed

Li, Rong-Yu; Wu, Xiao-Mao; Yin, Xian-Hui; Liang, Jing-Nan; Li, Ming

2014-07-15

In order to find a natural alternative to the synthetic fungicides currently used against the devastating rice blast fungus, Magnaporthe grisea, this study explored the antifungal potential of citral and its mechanism of action. It was found that citral not only inhibited hyphal growth of M. grisea, but also caused a series of marked hyphal morphological and structural alterations. Specifically, citral was tested for antifungal activity against M. grisea in vitro and was found to significantly inhibit colony development and mycelial growth with IC50 and IC90 values of 40.71 and 203.75 μg/mL, respectively. Furthermore, citral reduced spore germination and germ tube length in a concentration-dependent manner. Following exposure to citral, the hyphal cell surface became wrinkled with folds and cell breakage that were observed under scanning electron microscopy (SEM). There was damage to hyphal cell walls and membrane structures, loss of villous-like material outside of the cell wall, thinning of the cell wall, and discontinuities formed in the cell membrane following treatment based on transmission electron microscopy (TEM). This increase in chitinase activity both supports the morphological changes seen in the hyphae, and also suggests a mechanism of action. In conclusion, citral has strong antifungal properties, and treatment with this compound is capable of causing significant damage to the hyphal cell walls of M. grisea.

The exploration study of fire damage to concrete specimen using x-ray computed tomography

NASA Astrophysics Data System (ADS)

Su, Yu-Min; Lee, Min-Gin; Chen, Guan-Ying

2015-04-01

Portland Cement Concrete (PCC) loses the evaporable water at about 100 °C, decomposes C-S-H at about 200 °C, and dehydrates CH at about 500 °C, and deconstruct C-S-H at about 900°C. The concrete degradation or cracks are caused by several possible parameters, such as vapor pressure in pores, thermal gradient, and varied expansion rates of cement pastes and aggregates. The objective of the exploration study was to assess the porosity before and after conditioning of high temperature in the laboratory with the medical X-ray computed tomography. The experimental program was determined to identify the mineral properties of the aggregates used and determine the consensus properties of compressive, splitting tensile, and flexural strengths. Concrete cylinders were subject with one temperature conditioning, namely 400°C, but two different heat conditioning time namely four and eight hours. The X-ray CT, before and after high temperature conditioning, was administrated on the concrete cylinders to inspect the depth of the damage zone, which shall consist of more porosity than undamaged one. The damage zone will be examined and identified through the changes in porosity of concrete paste and aggregates within a concrete cylinder. The significance of the exploration study was to provide an in-depth insight to define the damaged zone for a better understanding of the following repairing and reinforced work.

Development of Integrated Flood Analysis System for Improving Flood Mitigation Capabilities in Korea

NASA Astrophysics Data System (ADS)

Moon, Young-Il; Kim, Jong-suk

2016-04-01

Recently, the needs of people are growing for a more safety life and secure homeland from unexpected natural disasters. Flood damages have been recorded every year and those damages are greater than the annual average of 2 trillion won since 2000 in Korea. It has been increased in casualties and property damages due to flooding caused by hydrometeorlogical extremes according to climate change. Although the importance of flooding situation is emerging rapidly, studies related to development of integrated management system for reducing floods are insufficient in Korea. In addition, it is difficult to effectively reduce floods without developing integrated operation system taking into account of sewage pipe network configuration with the river level. Since the floods result in increasing damages to infrastructure, as well as life and property, structural and non-structural measures should be urgently established in order to effectively reduce the flood. Therefore, in this study, we developed an integrated flood analysis system that systematized technology to quantify flood risk and flood forecasting for supporting synthetic decision-making through real-time monitoring and prediction on flash rain or short-term rainfall by using radar and satellite information in Korea. Keywords: Flooding, Integrated flood analysis system, Rainfall forecasting, Korea Acknowledgments This work was carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ011686022015)" Rural Development Administration, Republic of Korea

Structural changes of polymer-coated microgranules and excipients on tableting investigated by microtomography using synchrotron X-ray radiation.

PubMed

Kajihara, Ryusuke; Noguchi, Shuji; Iwao, Yasunori; Suzuki, Yoshio; Terada, Yasuko; Uesugi, Kentaro; Itai, Shigeru

2015-03-15

Multiple-unit tablets consisting of polymer-coated microgranules and excipients have a number of advantageous pharmaceutical properties. Polymer-coated microgranules are known to often lose their functionality because of damage to the polymer coating caused by tableting, and the mechanism of polymer coating damage as well as the structural changes of excipients upon tableting had been investigated but without in-situ visualization and quantitative analysis. To elucidate the mechanism of coating damage, the internal structures of multiple-unit tablets were investigated by X-ray computed microtomography using synchrotron X-rays. Cross sectional images of the tablets with sub-micron spatial resolution clearly revealed that void spaces remained around the compressed excipient particles in the tablets containing an excipient composed of cellulose and lactose (Cellactose(®) 80), whereas much smaller void spaces remained in the tablets containing an excipient made of sorbitol (Parteck(®) SI 150). The relationships between the void spaces and the physical properties of the tablets such as hardness and disintegration were investigated. Damage to the polymer coating in tablets was found mainly where polymer-coated microgranules were in direct contact with each other in both types of tablets, which could be attributed to the difference in hardness of excipient particles and the core of the polymer-coated microgranules. Copyright © 2015 Elsevier B.V. All rights reserved.

Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling.

PubMed

Dong, Liqun; Zhou, Shu; Yang, Xiaohua; Chen, Qianming; He, Yang; Huang, Wen

2013-07-01

Magnolol, an orally available compound from Magnolia officinalis used widely in traditional herbal medicine against a variety of neuronal diseases, possesses potent antioxidant properties and protects the brain against oxidative damage. The aim of the work is to examine the protective mechanisms of magnolol on human neuroblastoma SH-SY5Y cells against apoptosis induced by the neurotoxin acrolein, which can cause neurodegenerative disorders by inducing oxidative stress. By investigating the effect of magnolol on neural cell damage induced by the neurotoxin acrolein, we found that magnolol pretreatment significantly attenuated acrolein-induced oxidative stress through inhibiting reactive oxygen species accumulation caused by intracellular glutathione depletion and nicotinamide adenine dinucleotide phosphate oxidase activation. We next examined the signaling cascade(s) involved in magnolol-mediated antiapoptotic effects. The results showed that acrolein induced SH-SY5Y cell apoptosis by activating mitochondria/caspase and MEK/ERK signaling pathways. Our findings provide the first evidence that magnolol protects SH-SY5Y cells against acrolein-induced oxidative stress and prolongs SH-SY5Y cell survival through regulating JNK/mitochondria/caspase, PI3K/MEK/ERK, and PI3K/Akt/FoxO1 signaling pathways.

SCHISTOSOMICIDAL ACTIVITY OF THE CRUDE EXTRACT OF ARTOCARPUS LAKOOCHA.

PubMed

Preyavichyapugdee, Narin; Sangfuang, Manaw; Chaiyapum, Saowapark; Sriburin, Suwatcharaporn; Pootaeng-on, Yupa; Chusongsang, Phiraphol; Jiraungkoorskul, Wannee; Preyavichyapugdee, Mananya; Sobhon, Prasert

2016-01-01

Puag-Haad is a traditional anthelmintic drug used to treat taeniasis in Thailand and Lao PDR. It is derived from the aqueous extract of the plant Artocarpus lakoocha. We investigated the in vitro anthelmintic properties of Puag-Haad against Schistosoma mansoni. Adult worms were incubated in M-199 medium containing 250, 500 and 750 μg/ml of Puag-Haad or praziquantel (PZQ) at a concentration of 175 μg/ml for 3, 6, 12 and 24 hours. The relative motility (RM value), survival index (SI) and tegument alterations seen under scanning electron microscope were assessed at each incubation time. The results showed the crude extract of A. lakoocha at a concentration of 250 μg/ml was more effective in causing damage than PZQ at a concentration of 175 μg/ml using RM and SI values. The major target organ affected by Puag-Haad was the tegument. The damage was greater at higher concentrations of the crude extract. It is likely tetrahydroxystilbene (THS), the main compound in Puag-Haad, caused the damage. THS could be a future candidate as a schistosomal drug. Further studies are needed to explore its mechanism, efficiency and safety in vivo.

Radiation and Thermal Ageing of Nuclear Waste Glass

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, William J

2014-01-01

The radioactive decay of fission products and actinides incorporated into nuclear waste glass leads to self-heating and self-radiation effects that may affect the stability, structure and performance of the glass in a closed system. Short-lived fission products cause significant self-heating for the first 600 years. Alpha decay of the actinides leads to self-radiation damage that can be significant after a few hundred years, and over the long time periods of geologic disposal, the accumulation of helium and radiation damage from alpha decay may lead to swelling, microstructural evolution and changes in mechanical properties. Four decades of research on the behaviormore » of nuclear waste glass are reviewed.« less

The effect of nonablative laser energy on joint capsular properties. An in vitro histologic and biochemical study using a rabbit model

NASA Technical Reports Server (NTRS)

Hayashi, K.; Thabit, G. 3rd; Vailas, A. C.; Bogdanske, J. J.; Cooley, A. J.; Markel, M. D.

1996-01-01

The purpose of this study was to evaluate the effect of laser energy at nonablative levels on joint capsular histologic and biochemical properties in an in vitro rabbit model. The medial and lateral portions of the femoropatellar joint capsule from both stifles of 12 mature New Zealand White rabbits were used. Specimens were divided into three treatment groups (5 watts, 10 watts, and 15 watt) and one control group using a randomized block design. Specimens were placed in a 37 degrees bath of lactated Ringer's solution and laser energy was applied using a holmium:yttrium-aluminum-garnet laser in four transverse passes across the tissue at a velocity of 2 mm/sec with the handpiece set 1.5 mm from the synovial surface. Histologic analysis revealed thermal alteration of collagen (fusion) and fibroblasts (pyknosis) at all energy densities, with higher laser energy causing significantly greater morphologic changes over a larger area (P < 0.05). Application of laser energy did not significantly alter the biochemical parameters evaluated, including type I collagen content and nonreducible crosslinks (P > 0.05). This study demonstrated that nonablative laser energy caused significant thermal damage to the joint capsular tissue in an energy-dependent fashion, but type I collagen content and nonreducible crosslinks (P > 0.05). This study demonstrated that nonablative laser energy caused significant thermal damage to the joint capsular tissue in an energy-dependent fashion, but type I Collagen content and nonreducible corsslinks were not significantly altered.

The impact of unilateral brain damage on anticipatory grip force scaling when lifting everyday objects.

PubMed

Eidenmüller, S; Randerath, J; Goldenberg, G; Li, Y; Hermsdörfer, J

2014-08-01

The scaling of our finger forces according to the properties of manipulated objects is an elementary prerequisite of skilled motor behavior. Lesions of the motor-dominant left brain may impair several aspects of motor planning. For example, limb-apraxia, a tool-use disorder after left brain damage is thought to be caused by deficient recall or integration of tool-use knowledge into an action plan. The aim of the present study was to investigate whether left brain damage affects anticipatory force scaling when lifting everyday objects. We examined 26 stroke patients with unilateral brain damage (16 with left brain damage, ten with right brain damage) and 21 healthy control subjects. Limb apraxia was assessed by testing pantomime of familiar tool-use and imitation of meaningless hand postures. Participants grasped and lifted twelve randomly presented everyday objects. Grip force was measured with help of sensors fixed on thumb, index and middle-finger. The maximum rate of grip force was determined to quantify the precision of anticipation of object properties. Regression analysis yielded clear deficits of anticipation in the group of patients with left brain damage, while the comparison of patient with right brain damage with their respective control group did not reveal comparable deficits. Lesion-analyses indicate that brain structures typically associated with a tool-use network in the left hemisphere play an essential role for anticipatory grip force scaling, especially the left inferior frontal gyrus (IFG) and the premotor cortex (PMC). Furthermore, significant correlations of impaired anticipation with limb apraxia scores suggest shared representations. However, the presence of dissociations, implicates also independent processes. Overall, our findings suggest that the left hemisphere is engaged in anticipatory grip force scaling for lifting everyday objects. The underlying neural substrate is not restricted to a single region or stream; instead it may rely on the intact functioning of a left hemisphere network that may overlap with the left hemisphere dominant tool-use network. Copyright © 2014 Elsevier Ltd. All rights reserved.

Products Liability and Tort Risk Distribution in Government Contract Programs

DTIC Science & Technology

1978-09-30

IndemnityStatutes . . . . . . . . . . . . . . . . . . . . .126 E. Swine Flu Immunization Act. . . . . . . . . . . . .126 F. Teton Dam Act...handle 311 discovery and other preliminary matters. Litigation under the Swine Flu Act can be expected to continue for a number of years. F. Teton Dam ...Act On June 5, 1976, the Teton Dam collapsed in Idaho, killing 11 persons, injuring more than 100 -others and causing property 312 damage in excess of

Learn from the burn: The High Park Fire 5 years later

Treesearch

Sue Miller; Charles Rhodes; Pete Robichaud; Sandra Ryan; Jen Kovecses; Carl Chambers; Sara Rathburn; Jared Heath; Stephanie Kampf; Codie Wilson; Dan Brogan; Brad Piehl; Mary Ellen Miller; John Giordanengo; Erin Berryman; Monique Rocca

2017-01-01

It has been 5 years since the High Park Fire burned over 85,000 acres in Northern Colorado, causing extensive property damage, loss of life, and severe impacts to the water quality of the Poudre River. In the fall of 2016, a conference was organized by the USFS Rocky Mountain Research Station and the Coalition for the Poudre River Watershed to discuss what has been...

Liquefaction-induced lateral spreading in Oceano, California, during the 2003 San Simeon Earthquake

USGS Publications Warehouse

Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.; Di Alessandro, Carola; Boatwright, John; Tinsley, John C.; Sell, Russell W.; Rosenberg, Lewis I.

2004-01-01

The December 22, 2003, San Simeon, California, (M6.5) earthquake caused damage to houses, road surfaces, and underground utilities in Oceano, California. The community of Oceano is approximately 50 miles (80 km) from the earthquake epicenter. Damage at this distance from a M6.5 earthquake is unusual. To understand the causes of this damage, the U.S. Geological Survey conducted extensive subsurface exploration and monitoring of aftershocks in the months after the earthquake. The investigation included 37 seismic cone penetration tests, 5 soil borings, and aftershock monitoring from January 28 to March 7, 2004. The USGS investigation identified two earthquake hazards in Oceano that explain the San Simeon earthquake damage?site amplification and liquefaction. Site amplification is a phenomenon observed in many earthquakes where the strength of the shaking increases abnormally in areas where the seismic-wave velocity of shallow geologic layers is low. As a result, earthquake shaking is felt more strongly than in surrounding areas without similar geologic conditions. Site amplification in Oceano is indicated by the physical properties of the geologic layers beneath Oceano and was confirmed by monitoring aftershocks. Liquefaction, which is also commonly observed during earthquakes, is a phenomenon where saturated sands lose their strength during an earthquake and become fluid-like and mobile. As a result, the ground may undergo large permanent displacements that can damage underground utilities and well-built surface structures. The type of displacement of major concern associated with liquefaction is lateral spreading because it involves displacement of large blocks of ground down gentle slopes or towards stream channels. The USGS investigation indicates that the shallow geologic units beneath Oceano are very susceptible to liquefaction. They include young sand dunes and clean sandy artificial fill that was used to bury and convert marshes into developable lots. Most of the 2003 damage was caused by lateral spreading in two separate areas, one near Norswing Drive and the other near Juanita Avenue. The areas coincided with areas with the highest liquefaction potential found in Oceano. Areas with site amplification conditions similar to those in Oceano are particularly vulnerable to earthquakes. Site amplification may cause shaking from distant earthquakes, which normally would not cause damage, to increase locally to damaging levels. The vulnerability in Oceano is compounded by the widespread distribution of highly liquefiable soils that will reliquefy when ground shaking is amplified as it was during the San Simeon earthquake. The experience in Oceano can be expected to repeat because the region has many active faults capable of generating large earthquakes. In addition, liquefaction and lateral spreading will be more extensive for moderate-size earthquakes that are closer to Oceano than was the 2003 San Simeon earthquake. Site amplification and liquefaction can be mitigated. Shaking is typically mitigated in California by adopting and enforcing up-to-date building codes. Although not a guarantee of safety, application of these codes ensures that the best practice is used in construction. Building codes, however, do not always require the upgrading of older structures to new code requirements. Consequently, many older structures may not be as resistant to earthquake shaking as new ones. For older structures, retrofitting is required to bring them up to code. Seismic provisions in codes also generally do not apply to nonstructural elements such as drywall, heating systems, and shelving. Frequently, nonstructural damage dominates the earthquake loss. Mitigation of potential liquefaction in Oceano presently is voluntary for existing buildings, but required by San Luis Obispo County for new construction. Multiple mitigation procedures are available to individual property owners. These procedures typically involve either

Synthesis and testing of a conducting polymeric composite material for lightning strike protection applications

NASA Astrophysics Data System (ADS)

Katunin, A.; Krukiewicz, K.; Turczyn, R.; Sul, P.; Łasica, A.; Catalanotti, G.; Bilewicz, M.

2017-02-01

Lightning strike protection is one of the important issues in the modern maintenance problems of aircraft. This is due to a fact that the most of exterior elements of modern aircraft is manufactured from polymeric composites which are characterized by isolating electrical properties, and thus cannot carry the giant electrical charge when the lightning strikes. This causes serious damage of an aircraft structure and necessity of repairs and tests before returning a vehicle to operation. In order to overcome this problem, usually metallic meshes are immersed in the polymeric elements. This approach is quite effective, but increases a mass of an aircraft and significantly complicates the manufacturing process. The approach proposed by the authors is based on a mixture of conducting and dielectric polymers. Numerous modeling studies which are based on percolation clustering using kinetic Monte Carlo methods, finite element modeling of electrical and mechanical properties, and preliminary experimental studies, allow achieving an optimal content of conducting particles in a dielectric matrix in order to achieve possibly the best electrical conductivity and mechanical properties, simultaneously. After manufacturing the samples with optimal content of a conducting polymer, mechanical and electrical characterization as well as high-voltage testing was performed. The application of such a material simplifies manufacturing process and ensures unique properties of aircraft structures, which allows for minimizing damage after lightning strike, as well as provide electrical bounding and grounding, interference shielding, etc. The proposed solution can minimize costs of repair, testing and certification of aircraft structures damaged by lightning strikes.

41 CFR 102-37.250 - What actions must a SASP take when it learns of damage to or loss of surplus property in its...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What actions must a SASP take when it learns of damage to or loss of surplus property in its custody? 102-37.250 Section 102-37... learns of damage to or loss of surplus property in its custody? If you learn that surplus property in...

41 CFR 102-37.250 - What actions must a SASP take when it learns of damage to or loss of surplus property in its...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What actions must a SASP take when it learns of damage to or loss of surplus property in its custody? 102-37.250 Section 102-37... learns of damage to or loss of surplus property in its custody? If you learn that surplus property in...

49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

Code of Federal Regulations, 2011 CFR

2011-10-01

... included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints, warranty claims, and... code, the number of such property damage claims, consumer complaints, warranty claims, or field reports...

49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

Code of Federal Regulations, 2014 CFR

2014-10-01

... included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints, warranty claims, and... code, the number of such property damage claims, consumer complaints, warranty claims, or field reports...

49 CFR 579.21 - Reporting requirements for manufacturers of 5,000 or more light vehicles annually.

Code of Federal Regulations, 2011 CFR

2011-10-01

... codes to be included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints... or rollover indicated by the code. If an underlying property damage claim, consumer complaint...

49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

Code of Federal Regulations, 2012 CFR

2012-10-01

... included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints, warranty claims, and... code, the number of such property damage claims, consumer complaints, warranty claims, or field reports...

49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

Code of Federal Regulations, 2013 CFR

2013-10-01

... included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints, warranty claims, and... code, the number of such property damage claims, consumer complaints, warranty claims, or field reports...

49 CFR 579.21 - Reporting requirements for manufacturers of 5,000 or more light vehicles annually.

Code of Federal Regulations, 2012 CFR

2012-10-01

... codes to be included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints... or rollover indicated by the code. If an underlying property damage claim, consumer complaint...

49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

Code of Federal Regulations, 2010 CFR

2010-10-01

... included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints, warranty claims, and... code, the number of such property damage claims, consumer complaints, warranty claims, or field reports...

Judgments of damage to public versus private property in Chinese children at different historical times.

PubMed

Chen, Xinyin; Li, Dan; Liu, Junsheng; Chen, Huichang; Zhao, Siman

2018-01-01

This study examined children's judgments of damage to public versus private property in China at two historical times. Participants were two cohorts (1980 and 2012) of elementary school children at ages 7, 9, and 11 years. The children were administered paired stories that described a protagonist who damaged public or private property with a good or bad intention. The results showed that children in the 2012 cohort were less likely than their counterparts in the 1980 cohort to judge damage to public property as more culpable than damage to private property. The cohort differences were more evident in older children than in younger children. The results suggest that macro-level contexts may play an important role in shaping children's judgments. © 2016 John Wiley & Sons Ltd.

Electrically conductive carbon fibre-reinforced composite for aircraft lightning strike protection

NASA Astrophysics Data System (ADS)

Katunin, Andrzej; Krukiewicz, Katarzyna; Turczyn, Roman; Sul, Przemysław; Bilewicz, Marcin

2017-05-01

Aircraft elements, especially elements of exterior fuselage, are subjected to damage caused by lightning strikes. Due to the fact that these elements are manufactured from polymeric composites in modern aircraft, and thus, they cannot conduct electrical charges, the lightning strikes cause burnouts in composite structures. Therefore, the effective lightning strike protection for such structures is highly desired. The solution presented in this paper is based on application of organic conductive fillers in the form of intrinsically conducting polymers and carbon fabric in order to ensure electrical conductivity of whole composite and simultaneously retain superior mechanical properties. The presented studies cover synthesis and manufacturing of the electrically conductive composite as well as its characterization with respect to mechanical and electrical properties. The performed studies indicate that the proposed material can be potentially considered as a constructional material for aircraft industry, which characterizes by good operational properties and low cost of manufacturing with respect to current lightning strike protection materials solutions.

Study of the surface activation of ETFE by low energy (keV) Si and N bombardment

NASA Astrophysics Data System (ADS)

Parada, M. A.; de Almeida, A.; Muntele, C.; Muntele, I.; Delalez, N.; Ila, D.

2005-12-01

The ethylenetetrafluoroethylene (ETFE) is a polymer formed by alternating ethylene and tetrafluoroethylene segments. It can be applied in the field of medical physics as intra venous catheters and as radiation dosimeters. The increasing application of polymeric materials in technological and scientific fields has motivated the use of surface treatments to modify the physical and chemical properties of polymer surfaces. When a material is exposed to ionizing radiation, it suffers damage leading to surface activation depending on the type, energy and intensity of the applied radiation. In order to determine the radiation damage and the surface activation mechanism ETFE films were bombarded with keV Si and N at various fluences. The bombarded film was also analyzed with optical absorption photospectrometry (OAP), Raman and Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy showing quantitatively the chemical nature at the damage caused by the Si and N bombardment.

Roughness Effects on Fretting Fatigue

NASA Astrophysics Data System (ADS)

Yue, Tongyan; Abdel Wahab, Magd

2017-05-01

Fretting is a small oscillatory relative motion between two normal loaded contact surfaces. It may cause fretting fatigue, fretting wear and/or fretting corrosion damage depending on various fretting couples and working conditions. Fretting fatigue usually occurs at partial slip condition, and results in catastrophic failure at the stress levels below the fatigue limit of the material. Many parameters may affect fretting behaviour, including the applied normal load and displacement, material properties, roughness of the contact surfaces, frequency, etc. Since fretting damage is undesirable due to contacting, the effect of rough contact surfaces on fretting damage has been studied by many researchers. Experimental method on this topic is usually focusing on rough surface effects by finishing treatment and random rough surface effects in order to increase fretting fatigue life. However, most of numerical models on roughness are based on random surface. This paper reviewed both experimental and numerical methodology on the rough surface effects on fretting fatigue.

Environmental factors and unhealthy lifestyle influence oxidative stress in humans--an overview.

PubMed

Aseervatham, G Smilin Bell; Sivasudha, T; Jeyadevi, R; Arul Ananth, D

2013-07-01

Oxygen is the most essential molecule for life; since it is a strong oxidizing agent, it can aggravate the damage within the cell by a series of oxidative events including the generation of free radicals. Antioxidative agents are the only defense mechanism to neutralize these free radicals. Free radicals are not only generated internally in our body system but also trough external sources like environmental pollution, toxic metals, cigarette smoke, pesticides, etc., which add damage to our body system. Inhaling these toxic chemicals in the environment has become unavoidable in modern civilization. Antioxidants of plant origin with free radical scavenging properties could have great importance as therapeutic agents in several diseases caused by environmental pollution. This review summarizes the generation of reactive oxygen species and damage to cells by exposure to external factors, unhealthy lifestyle, and role of herbal plants in scavenging these reactive oxygen species.

Analysis of Radiation Damage in Light Water Reactors: Comparison of Cluster Analysis Methods for the Analysis of Atom Probe Data.

PubMed

Hyde, Jonathan M; DaCosta, Gérald; Hatzoglou, Constantinos; Weekes, Hannah; Radiguet, Bertrand; Styman, Paul D; Vurpillot, Francois; Pareige, Cristelle; Etienne, Auriane; Bonny, Giovanni; Castin, Nicolas; Malerba, Lorenzo; Pareige, Philippe

2017-04-01

Irradiation of reactor pressure vessel (RPV) steels causes the formation of nanoscale microstructural features (termed radiation damage), which affect the mechanical properties of the vessel. A key tool for characterizing these nanoscale features is atom probe tomography (APT), due to its high spatial resolution and the ability to identify different chemical species in three dimensions. Microstructural observations using APT can underpin development of a mechanistic understanding of defect formation. However, with atom probe analyses there are currently multiple methods for analyzing the data. This can result in inconsistencies between results obtained from different researchers and unnecessary scatter when combining data from multiple sources. This makes interpretation of results more complex and calibration of radiation damage models challenging. In this work simulations of a range of different microstructures are used to directly compare different cluster analysis algorithms and identify their strengths and weaknesses.

Effects of ionizing radiation on bio-active plant extracts useful for preventing oxidative damages.

PubMed

Mulinacci, Nadia; Valletta, Alessio; Pasqualetti, Valentina; Innocenti, Marzia; Giuliani, Camilla; Bellumori, Maria; De Angelis, Giulia; Carnevale, Alessia; Locato, Vittoria; Di Venanzio, Cristina; De Gara, Laura; Pasqua, Gabriella

2018-04-02

Humans are exposed to ionizing radiations in medical radiodiagnosis and radiotherapy that cause oxidative damages and degenerative diseases. Airplane pilots, and even more astronauts, are exposed to a variety of potentially harmful factors, including cosmic radiations. Among the phytochemicals, phenols are particularly efficient in countering the oxidative stress. In the present study, different extracts obtained from plant food, plant by-products and dietary supplements, have been compared for their antioxidant properties before and after irradiation of 140 cGy, a dose absorbed during a hypothetical stay of three years in the space. All the dry extracts, characterized in terms of vitamin C and phenolic content, remained chemically unaltered and maintained their antioxidant capability after irradiation. Our results suggest the potential use of these extracts as nutraceuticals to protect humans from oxidative damages, even when these extracts must be stored in an environment exposed to cosmic radiations as in a space station.

36 CFR 9.51 - Damages and penalties.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Damages and penalties. 9.51... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.51 Damages and penalties. (a) The operator shall be... employees from any damages or claims for injury or death of persons and damage or loss of property by any...

36 CFR 9.51 - Damages and penalties.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Damages and penalties. 9.51... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.51 Damages and penalties. (a) The operator shall be... employees from any damages or claims for injury or death of persons and damage or loss of property by any...

36 CFR 9.51 - Damages and penalties.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Damages and penalties. 9.51... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.51 Damages and penalties. (a) The operator shall be... employees from any damages or claims for injury or death of persons and damage or loss of property by any...

36 CFR 9.51 - Damages and penalties.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Damages and penalties. 9.51... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.51 Damages and penalties. (a) The operator shall be... employees from any damages or claims for injury or death of persons and damage or loss of property by any...

36 CFR 9.51 - Damages and penalties.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Damages and penalties. 9.51... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.51 Damages and penalties. (a) The operator shall be... employees from any damages or claims for injury or death of persons and damage or loss of property by any...

On the monitoring and implications of growing damages caused by manufacturing defects in composite structures

NASA Astrophysics Data System (ADS)

Schagerl, M.; Viechtbauer, C.; Hörrmann, S.

2015-07-01

Damage tolerance is a classical safety concept for the design of aircraft structures. Basically, this approach considers possible damages in the structure, predicts the damage growth under applied loading conditions and predicts the following decrease of the structural strength. As a fundamental result the damage tolerance approach yields the maximum inspection interval, which is the time a damage grows from a detectable to a critical level. The above formulation of the damage tolerance safety concept targets on metallic structures where the damage is typically a simple fatigue crack. Fiber-reinforced polymers show a much more complex damage behavior, such as delaminationsin laminated composites. Moreover, progressive damage in composites is often initiated by manufacturing defects. The complex manufacturing processes for composite structures almost certainly yield parts with defects, e.g. pores in the matrix or undulations of fibers. From such defects growing damages may start after a certain time of operation. The demand to simplify or even avoid the inspection of composite structures has therefore led to a comeback of the traditional safe-life safety concept. The aim of the so-called safe-life flaw tolerance concept is a structure that is capable of carrying the static loads during operation, despite significant damages and after a representative fatigue load spectrum. A structure with this property does not need to be inspected, respectively monitored at all during its service life. However, its load carrying capability is thereby not fully utilized. This article presents the possible refinement of the state-of-the-art safe-life flaw tolerance concept for composite structures towards a damage tolerance approach considering also the influence of manufacturing defects on damage initiation and growth. Based on fundamental physical relations and experimental observations the challenges when developing damage growth and residual strength curves are discussed.

An association of cocoa consumption with improved physical fitness and decreased muscle damage and oxidative stress in athletes.

PubMed

González-Garrido, José A; García-Sánchez, José R; Garrido-Llanos, Silvia; Olivares-Corichi, Ivonne M

2017-04-01

Several studies have demonstrated the protective effects of cocoa consumption, due to its anti-inflammatory and antioxidant properties. Acute exercise induces oxidative stress and causes muscular damage during training. This study was designed to examine the effect of cocoa consumption on the markers of muscle damage, oxidative stress and physical fitness in professional soccer players. Fifteen players (15-18 years old) were included in the study. Biochemical parameters, markers of muscle damage and oxidative stress, and physical performance were evaluated before and after cocoa consumption. Biochemical parameters determined the healthy metabolic status of the study group; biomarkers of muscle and oxidative damage were measured in blood to establish muscle and redox status. However, high levels of biomarkers of muscle damage were detected. Interestingly, cocoa consumption decreased the muscle damage biomarkers of CK and LDH by 39.4% and 23.03%, respectively. The redox status was modified by a decrease in oxidative damage (carbonyl groups, 26.31%; thiol groups, 27.52%; MDA, 32.42%) and an increase in total antioxidant capacity (15.98%) and GSH-Px activity (26.37%). In addition, we observed an increase in physical performance by 4% in the Cooper Test. Our findings suggest that a short period of cocoa consumption could be useful in maintaining a good physical fitness, due to the favourable effects on muscle and redox status in athletes during exhaustive exercise.

A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage.

PubMed

Maxwell, Adam D; Wang, Tzu-Yin; Yuan, Lingqian; Duryea, Alexander P; Xu, Zhen; Cain, Charles A

2010-12-01

Many ultrasound studies involve the use of tissue-mimicking materials to research phenomena in vitro and predict in vivo bioeffects. We have developed a tissue phantom to study cavitation-induced damage to tissue. The phantom consists of red blood cells suspended in an agarose hydrogel. The acoustic and mechanical properties of the gel phantom were found to be similar to soft tissue properties. The phantom's response to cavitation was evaluated using histotripsy. Histotripsy causes breakdown of tissue structures by the generation of controlled cavitation using short, focused, high-intensity ultrasound pulses. Histotripsy lesions were generated in the phantom and kidney tissue using a spherically focused 1-MHz transducer generating 15 cycle pulses, at a pulse repetition frequency of 100 Hz with a peak negative pressure of 14 MPa. Damage appeared clearly as increased optical transparency of the phantom due to rupture of individual red blood cells. The morphology of lesions generated in the phantom was very similar to that generated in kidney tissue at both macroscopic and cellular levels. Additionally, lesions in the phantom could be visualized as hypoechoic regions on a B-mode ultrasound image, similar to histotripsy lesions in tissue. High-speed imaging of the optically transparent phantom was used to show that damage coincides with the presence of cavitation. These results indicate that the phantom can accurately mimic the response of soft tissue to cavitation and provide a useful tool for studying damage induced by acoustic cavitation. Copyright © 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Nanotribological effects of hair care products and environment on human hair using atomic force microscopy

NASA Astrophysics Data System (ADS)

Latorre, Carmen; Bhushan, Bharat

2005-07-01

Tribological properties are useful in the study of human hair and other biological materials. Major sources of investigation for conditioner treated hair includes localization of conditioner, mechanisms related to changes in surface roughness, friction, and adhesion on the nanoscale due to conditioner agents, and how the products change the microstructure of the cuticle. The paper presents nanotribological studies investigating surface roughness, friction, and adhesion using atomic force/friction force microscopy (AFM/FFM). Test samples include virgin and chemically damaged hair, both with and without commercial conditioner treatment, as well as chemically damaged hair with experimental conditioner treatments. Friction force mapping provides insight into the localized change in friction caused by the application of hair care materials. Adhesive force maps to study adhesion on the cuticle surface provide information about localization and distribution of conditioner as well. A discussion is presented on these properties of hair as a function of relative humidity, temperature, durability, and conditioning treatments.

Safety Modification of Cam-and-Groove Hose Coupling

NASA Technical Reports Server (NTRS)

Schwindt, Paul; Littlefield, Alan

2008-01-01

A modification has been made in the mating halves of a cam-and-groove hose coupling to prevent rapid separation of the halves in the event that the cam levers are released while the fluid in the hose is pressurized. The need for this modification arises because commercial off-the-shelf cam-and-groove hose-coupling halves do not incorporate safety features to prevent separation in the pressurized state. Especially when the pressurized fluid is compressible (e.g., steam or compressed air), the separated halves can be propelled with considerable energy, causing personal injury and/or property damage. Therefore, one purpose served by the modification is to provide for venting to release compressive energy in a contained and safe manner while preventing personal injury and/or property damage. Another purpose served by the modification, during the process of connecting the coupling halves, is to ensure that the coupling halves are properly aligned before the cam levers can be locked into position.

Sacrificial Charge and the Spectral Resolution Performance of ACIS CCDs

NASA Astrophysics Data System (ADS)

Grant, Catherine E.; Prigozhin, Gregory; Lamarr, Beverly; Bautz, Mark W.

2002-04-01

Soon after launch, the Advanced CCD Imaging Spectrometer (ACIS), one of the focal plane instruments on the Chandra X-ray Observatory, suffered radiation damage from exposure to soft protons during passages through the Earth's radiation belts. The ACIS team is continuing to study the properties of the damage with an emphasis on developing techniques to mitigate charge transfer inefficiency (CTI) and spectral resolution degradation. A post-facto CTI corrector has been developed which can effectively recover much of the lost resolution (Townsley et al. 2000, ApJ, 534, L139). Any further improvements in performance will require knowledge of the location and amount of sacrificial charge - charge deposited along the readout path of an event which fills electron traps and changes CTI. We report on efforts by the ACIS Instrument team to characterize which charge traps cause performance degradation and the properties of the sacrificial charge seen on-orbit. We also report on early attempts to correct for the presence of sacrificial charge.

Sacrificial charge and the spectral resolution performance of the Chandra advanced CCD imaging spectrometer

NASA Astrophysics Data System (ADS)

Grant, Catherine E.; Prigozhin, Gregory Y.; LaMarr, Beverly; Bautz, Mark W.

2003-03-01

Soon after launch, the Advanced CCD Imaging Spectrometer (ACIS), one of the focal plane instruments on the Chandra X-ray Observatory, suffered radiation damage from exposure to soft protons during passages through the Earth's radiation belts. The ACIS team is continuing to study the properties of the damage with an emphasis on developing techniques to mitigate charge transfer inefficiency (CTI) and spectral resolution degradation. A post-facto CTI corrector has been developed which can effectively recover much of the lost resolution. Any further improvements in performance will require knowledge of the location and amount of sacrificial charge - charge deposited along the readout path of an event which fills electron traps and changes CTI. We report on efforts by the ACIS Instrument team to characterize which charge traps cause performance degradation and the properties of the sacrificial charge seen on-orbit. We also report on attempts to correct X-ray pulseheights for the presence of sacrificial charge.

Domestic Property Violence: A Distinct and Damaging Form of Parent Abuse.

PubMed

Murphy-Edwards, Latesha; van Heugten, Kate

2018-02-01

This article reports on the qualitative phase of mixed method research conducted in a medium-size city in New Zealand, which examined 14 parents' experiences of child- and youth-perpetrated domestic property violence (DPV). The research used semi-structured interviews and interpretative phenomenological analysis, enabling parents' perceptions of the causes and impacts of this form of family violence to be explored in depth. Three superordinate themes were identified in the analysis: damage done, the various impacts of DPV; staying safe and sane; and making sense of DPV, parents' perspectives. An ecological meaning-making theory emerged from the data and provided an overarching interpretative framework for considering the themes both separately and together. The findings showed that DPV is a distinct form of parent abuse and one that can have serious impacts of a financial, emotional, and relational nature. The theoretical and practical implications of the findings are discussed along with ideas for further research into this problem.

Bioinspired porous membranes containing polymer nanoparticles for wound healing.

PubMed

Ferreira, Ana M; Mattu, Clara; Ranzato, Elia; Ciardelli, Gianluca

2014-12-01

Skin damages covering a surface larger than 4 cm(2) require a regenerative strategy based on the use of appropriate wound dressing supports to facilitate the rapid tissue replacement and efficient self-healing of the lost or damaged tissue. In the present work, A novel biomimetic approach is proposed for the design of a therapeutic porous construct made of poly(L-lactic acid) (PLLA) fabricated by thermally induced phase separation (TIPS). Biomimicry of ECM was achieved by immobilization of type I collagen through a two-step plasma treatment for wound healing. Anti-inflammatory (indomethacin)-containing polymeric nanoparticles (nps) were loaded within the porous membranes in order to minimize undesired cell response caused by post-operative inflammation. The biological response to the scaffold was analyzed by using human keratinocytes cell cultures. In this work, a promising biomimetic construct for wound healing and soft tissue regeneration with drug-release properties was fabricated since it shows (i) proper porosity, pore size, and mechanical properties, (ii) biomimicry of ECM, and (iii) therapeutic potential. © 2014 Wiley Periodicals, Inc.

Protective mechanisms of Moringa oleifera against CCl(4)-induced oxidative stress in precision-cut liver slices.

PubMed

Sreelatha, S; Padma, P R

2010-01-01

The present study was designed to evaluate the efficacy of Moringa oleifera leaves against carbon tetrachloride (CCl(4))-treated liver slices in vitro. The study evaluated the antioxidant properties of Moringa oleifera leaves against CCl(4)-induced oxidative damage in liver slices. CCl(4) treatment significantly decreased the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase and caused decreased glutathione content and increased the thiobarbituric acid-reacting substances (TBARS). Treatment with Moringa oleifera extract increased the activities of antioxidant enzymes and glutathione content and reduced the levels of TBARS significantly. Observed reduction in the level of lipid peroxides showed a decreased tendency of peroxidative damage. We conclude that, under these experimental conditions, the leaf extracts effectively suppress CCl(4)-induced oxidative stress. Our findings provide evidence to demonstrate that the possible mechanism of this activity may be due to the strong antioxidant property of the leaves. Copyright 2010 S. Karger AG, Basel.

30 CFR 220.011 - Schedule of allowable direct and allocable joint costs and credits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... household applicances, and purchases of insurance against damages to or loss of personal property are... approval. (h) Damages and losses to NPSL property. All costs necessary for the repair or replacement of NPSL property made necessary because of damages or losses incurred by fire, flood, storm, theft...

49 CFR 579.21 - Reporting requirements for manufacturers of 5,000 or more light vehicles annually.

Code of Federal Regulations, 2010 CFR

2010-10-01

... codes to be included. (c) Numbers of property damage claims, consumer complaints, warranty claims, and field reports. Separate reports on the numbers of those property damage claims, consumer complaints... report shall state, separately by each such code, the number of such property damage claims, consumer...

Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. & Thoms. roots (ACP) on APAP/CCl4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property.

PubMed

Shine, Varghese Jancy; Latha, Panikamparambil Gopalakrishnan; Suja, Somasekharan Nair Rajam; Anuja, Gangadharan Indira; Raj, Gopan; Rajasekharan, Sreedharan Nair

2014-02-01

To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata (C. peltata) against paracetamol/carbon tetra chloride induced liver damage in Wistar rats. In vivo paracetamol/carbon tetrachloride induced liver damage in Wistar rats, in vitro free radical scavenging studies, HPTLC estimation of tetrandrine and direct analysis in real time- mass spectrometry of alkaloid extract of C. peltata were used for the validation. The results showed that pretreatment with alkaloid extract of C. peltata caused significant reduction of serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, serum alkaline phosphatase, serum cholesterol, liver malondialdehyde levels. The reduced glutathione, catalase, superoxide dismutase levels in liver were increased with alkaloid extract of C. peltata treatment. These results were almost comparable to silymarin and normal control. Histopathological studies also substantiated the biochemical findings. The in vitro hydroxyl, superoxide and DPPH scavenging study of alkaloid extract of C. peltata showed significant free radical scavenging property. The hepatoprotective property of alkaloid extract of C. peltata against paracetamol/carbon tetrachloride may be due the synergistic action of alkaloids especially tetrandrine, fangchinoline through free radical scavenging and thus preventing oxidative stress.

Low doses of gamma radiation in the management of postharvest Lasiodiplodia theobromae in mangos

PubMed Central

Santos, Alice Maria Gonçalves; Lins, Severina Rodrigues Oliveira; da Silva, Josenilda Maria; de Oliveira, Sônia Maria Alves

2015-01-01

The postharvest life of mango is limited by the development of pathogens, especially fungi that cause rot, among which stands out the Lasiodiplodia theobromae. Several control methods have been employed to minimize the damages caused by this fungus, chemical control can leave residues to man and nature; physical control by the use of gamma radiation in combination with modified atmosphere and cold storage. The use of gamma radiation helps to reduce the severity of the pathogen assist in the ripening process of fruits, even at low doses (0.25, 0.35 and 0.45 kGy) chemical properties such as pH, soluble solids, acid ascorbic, titratable acidity and also the quality parameters of the pulp showed no damage that are ideal for trade and consumption of mangoes. This treatment can be extended for use in the management of diseases such as natural infections for penducular rot complex that has as one of L. theobroma pathogens involved. PMID:26413068

Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays.

PubMed

Erturk, Filiz Aygun; Aydin, Murat; Sigmaz, Burcu; Taspinar, M Sinan; Arslan, Esra; Agar, Guleray; Yagci, Semra

2015-12-01

Arsenic is a well-known toxic substance on the living organisms. However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. In the present study, effects of As2O3 (arsenic trioxide) on LTR retrotransposon polymorphism and DNA methylation as well as DNA damage in Zea mays seedlings were investigated. The results showed that all of arsenic doses caused a decreasing genomic template stability (GTS) and an increasing Random Amplified Polymorphic DNAs (RAPDs) profile changes (DNA damage). In addition, increasing DNA methylation and LTR retrotransposon polymorphism characterized a model to explain the epigenetically changes in the gene expression were also found. The results of this experiment have clearly shown that arsenic has epigenetic effect as well as its genotoxic effect. Especially, the increasing of polymorphism of some LTR retrotransposon under arsenic stress may be a part of the defense system against the stress.

Root Cause Investigation of the Starboard Solar Alpha Rotary Joint Anomaly on the International Space Station

NASA Technical Reports Server (NTRS)

Taylor, Deneen; Enriquez, Carlos; McCann, David; McFatter, Justin

2010-01-01

The Solar Alpha Rotary Joint (SARJ) is a single-axis pointing mechanism used to orient the solar power generating arrays relative to the sun for the International Space Station (ISS). Approximately 83 days after its on-orbit installation, one of the two SARJ mechanisms aboard the ISS began to exhibit high current draw. Later inspections via Extravehicular Activity (EVA) discovered that the case hardened steel race ring on the outboard side of the joint had extensive damage to one of its three rolling surfaces. A far-reaching investigation of the anomaly was undertaken, comprising metallurgical inspections, coupon tests, traction kinematics tests, detailed bearing measurements, and thermal and structural analyses. The investigation found that the race ring damage had been caused by high bearing edge stresses that resulted from inadequate lubrication of the rolling contact. The profile of the roller bearings and the metallurgical properties of the race ring were also found to be significant contributing factors.

Mesoscale modeling of solute precipitation and radiation damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yongfeng; Schwen, Daniel; Ke, Huibin

2015-09-01

This report summarizes the low length scale effort during FY 2014 in developing mesoscale capabilities for microstructure evolution in reactor pressure vessels. During operation, reactor pressure vessels are subject to hardening and embrittlement caused by irradiation-induced defect accumulation and irradiation-enhanced solute precipitation. Both defect production and solute precipitation start from the atomic scale, and manifest their eventual effects as degradation in engineering-scale properties. To predict the property degradation, multiscale modeling and simulation are needed to deal with the microstructure evolution, and to link the microstructure feature to material properties. In this report, the development of mesoscale capabilities for defect accumulationmore » and solute precipitation are summarized. Atomic-scale efforts that supply information for the mesoscale capabilities are also included.« less

Economic effects of poor IAQ

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haymore, C.; Odom, R.

Poor indoor air quality (IAQ) takes its toll in a variety of ways. It damages health and possessions; it lowers productivity at work; and it diverts resources to diagnosing and solving problems that result from it. Although the economic costs of some of these damages are fairly tangible and easy to quantify, a large portion are hidden. The cumulative impact can easily reach into the billions of dollars. The cost to diagnose, mitigate, and litigate IAQ problems is evidenced by the burgeoning number of businesses providing these services. A recent EPA survey indicated that over 1,500 firms specialize in IAQmore » services, a 25-percent increase from 1988. The median price for evaluating and balancing ventilation systems ranges from $250 to $1,500. The median for duct-cleaning service is about $500 and for asbestos abatement and construction/renovation, about $5,000. Costs can be as high as $50,000 for some of these services. The economic costs of poor IAQ also include the actual damages to property caused by contaminants. Indoor air pollutants can damage metals, paints, textiles, paper, and magnetic storage media and can cause increased soiling, deterioration of appearance, and reduced service life for furniture draperies, interiors, and heating, ventilation, and air conditioning (HVAC) equipment. Injury to people represent an even larger cost of poor IAQ. EPA ranks IAQ problems as one of the largest remaining health risks in the US. Health effects range from the mildly irritating, such as headaches and allergies, to the life threatening, such as cancer and heart disease. One study indicated that for every 100 white collar workers, poor IAQ would cause an extra 24 doctor visits per year. This amounts to another $288 million.« less

[Mutagenic and antimutagenic properties of bemitil].

PubMed

Seredenin, S B; Bobkov, Iu G; Durnev, A D; Dubovskaia, O Iu

1986-07-01

Complex research of the genetic activity of a new 2-mercaptobenzimidazole derivative bemythyl has shown that the drug failed to induce recessive, age-related lethal mutations in drosophila, dominant lethal mutations in germ mammalian cells and chromosomal damage in murine bone marrow cells and human peripheral blood cell cultures. The experiments on mice have demonstrated that therapeutic bemythyl doses caused a two-fold decrease in the level of aberrant cells induced by alkylating agents--fotrin and fopurin.

Statistical analysis of low-rise building damage caused by the San Fernando earthquake

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholl, R.E.

1974-02-01

An empirical investigation of damage to low-rise buildings in two selected control areas within Glendale, California, caused by the ground motion precipitated by the San Fernando earthquake of February 9, 1971 is summarized. The procedures for obtaining the appropriate data and the methodology used in deriving ground motion-damage relationships are described. Motion-damage relationships are derived for overall damage and for the most frequently damaged building components. Overall motion-damage relationships are expressed in terms of damage incidence (damage ratio) and damage cost (damage cost factor). The motion-damage relationships derived from the earthquake data are compared with similar data obtained for lou-risemore » buildings subjected to ground motion generated by an underground nuclear explosion. Overall comparison results show that for the same spectral acceleration, the earthquake caused slightly more damage. Differences in ground-motion characteristics for the two types of disturbances provide the most probable explanation for this discrepancy. (auth)« less

On high explosive launching of projectiles for shock physics experiments

NASA Astrophysics Data System (ADS)

Swift, Damian C.; Forest, Charles A.; Clark, David A.; Buttler, William T.; Marr-Lyon, Mark; Rightley, Paul

2007-06-01

The hydrodynamic operation of the "Forest Flyer" type of explosive launching system for shock physics projectiles was investigated in detail using one and two dimensional continuum dynamics simulations. The simulations were numerically converged and insensitive to uncertainties in the material properties; they reproduced the speed of the projectile and the shape of its rear surface. The most commonly used variant, with an Al alloy case, was predicted to produce a slightly curved projectile, subjected to some shock heating and likely exhibiting some porosity from tensile damage. The curvature is caused by a shock reflected from the case; tensile damage is caused by the interaction of the Taylor wave pressure profile from the detonation wave with the free surface of the projectile. The simulations gave only an indication of tensile damage in the projectile, as damage is not understood well enough for predictions in this loading regime. The flatness can be improved by using a case of lower shock impedance, such as polymethyl methacrylate. High-impedance cases, including Al alloys but with denser materials improving the launching efficiency, can be used if designed according to the physics of oblique shock reflection, which indicates an appropriate case taper for any combination of explosive and case material. The tensile stress induced in the projectile depends on the relative thickness of the explosive, expansion gap, and projectile. The thinner the projectile with respect to the explosive, the smaller the tensile stress. Thus if the explosive is initiated with a plane wave lens, the tensile stress is lower than that for initiation with multiple detonators over a plane. The previous plane wave lens designs did, however, induce a tensile stress close to the spall strength of the projectile. The tensile stress can be reduced by changes in the component thicknesses. Experiments verifying the operation of explosively launched projectiles should attempt to measure porosity induced in the projectile: arrival time measurements are likely to be insensitive to porous regions caused by damaged or recollected material.

Nanofabrication and ion milling introduced effects on magnetic properties in magnetic recording

NASA Astrophysics Data System (ADS)

Sun, Zhenzhong

Perpendicular magnetic nanostructures have played an important role in magnetic recording technologies. In this dissertation, a systematic study on the CoPt magnetic nanostructures from fabrication, characterization to computer simulation has been performed. During the fabrication process, ion irradiation/bombardment in ion mill can cause physical damage to the magnetic nanostructures and degrade their magnetic properties. To study the effect of ion damage on CoPt nanostructures, different degrees of ion damage are introduced into CoPt nanopillars by varying the accelerating voltage in ion mill. The results demonstrate that the ion damage can reduce the coercivity by softening circumferential edge, and therefore changes the switching mechanism from coherent rotation to nucleation followed by rapid domain wall propagation. The SFD of CoPt nanostructures is independent of ion damage and is mainly determined by the intrinsic anisotropy distribution of the film rather than the nanostructure size distribution. Anisotropy-graded bit-patterned media are fabricated and studied based on high anisotropy L10-FePt material system. L10-FePt thin films with linearly and quadratically distributed anisotropy are achieved by varying substrate temperature during film growth. After patterning, the anisotropy-graded L10-FePt nanopillars display a reduced switching field and maintain a good thermal stability compared to the non-graded one. Experimental investigation and comparison further prove the concept of "anisotropy-graded" bit-patterned media and their potential application in the future magnetic recording. During magnetic write head fabrication, ion-beam damage may degrade the performance of the magnetic write pole. A surface sensitive MOKE is used to characterize the magnetic properties of these etched FeCo films. MOKE measurement shows a hard axis hysteresis loop with a high Mr in the high power etched film due to the ion beam introduced defects. The high power etched film also shows the highest RMS by AFM measurement. The geometric peaks at the top surface may have shape anisotropy and serve as the pinning sites. These magnetic pinning sites can prevent the nucleation center forming at the top surface during the switching process and lead to a high Mr in the top surface region.

29 CFR 15.42 - Claim procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Are there limits on claims under the MPCECA? 15.205 What types of claims for property damage are... a claim for loss of or damages to personal property under the WIA? 15.304 Are there limits to claims for loss of or damages to personal property under the WIA? Authority: 28 U.S.C. 2672; 28 CFR § 14.11...

43 CFR 422.13 - Reporting an injury or property damage or loss.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Requirements § 422.13 Reporting an injury or property damage or loss. (a) An officer must immediately report orally and in writing to his/her supervisor any: (1) Injury suffered while on duty; and (2) Any loss, damage, or theft of government property. (b) The written report must be in detail and must include names...

Does it make sense to modify tropical cyclones? A decision-analytic assessment.

PubMed

Klima, Kelly; Morgan, M Granger; Grossmann, Iris; Emanuel, Kerry

2011-05-15

Recent dramatic increases in damages caused by tropical cyclones (TCs) and improved understanding of TC physics have led DHS to fund research on intentional hurricane modification. We present a decision analytic assessment of whether it is potentially cost-effective to attempt to lower the wind speed of TCs approaching South Florida by reducing sea surface temperatures with wind-wave pumps. Using historical data on hurricanes approaching South Florida, we develop prior probabilities of how storms might evolve. The effects of modification are estimated using a modern TC model. The FEMA HAZUS-MH MR3 damage model and census data on the value of property at risk are used to estimate expected economic losses. We compare wind damages after storm modification with damages after implementing hardening strategies protecting buildings. We find that if it were feasible and properly implemented, modification could reduce net losses from an intense storm more than hardening structures. However, hardening provides "fail safe" protection for average storms that might not be achieved if the only option were modification. The effect of natural variability is larger than that of either strategy. Damage from storm surge is modest in the scenario studied but might be abated by modification.

Brain hemorrhage after electrical burn injury: Case report and probable mechanism.

PubMed

Axayacalt, Gutierrez Aceves Guillermo; Alejandro, Ceja Espinosa; Marcos, Rios Alanis; Inocencio, Ruiz Flores Milton; Alfredo, Herrera Gonzalez Jose

2016-01-01

High-voltage electric injury may induce lesion in different organs. In addition to the local tissue damage, electrical injuries may lead to neurological deficits, musculoskeletal damage, and cardiovascular injury. Severe vascular damage may occur making the blood vessels involved prone to thrombosis and spontaneous rupture. Here, we present the case of a 39-year-old male who suffered an electrical burn with high tension wire causing intracranial bleeding. He presented with an electrical burn in the parietal area (entry zone) and the left forearm (exit zone). The head tomography scan revealed an intraparenchimatous bleeding in the left parietal area. In this case, the electric way was the scalp, cranial bone, blood vessels and brain, upper limb muscle, and skin. The damage was different according to the dielectric property in each tissue. The injury was in the scalp, cerebral blood vessel, skeletal muscle, and upper limb skin. The main damage was in brain's blood vessels because of the dielectric and geometric features that lead to bleeding, high temperature, and gas delivering. This is a report of a patient with an electric brain injury that can be useful to elucidate the behavior of the high voltage electrical current flow into the nervous system.

First-Principles Investigation of Radiation Induced Defects in SiC and Si.

NASA Astrophysics Data System (ADS)

Windl, Wolfgang; Lenosky, Thomas J.; Kress, Joel D.; Voter, Arthur F.

1997-03-01

SiC shows promise as a structural material for fusion reactors, partly because of its low activation under neutron irradiation. This radiation, however, can cause damage to its crystal structure, thereby degrading its properties. The focus of this work is the understanding of this neutron-induced radiation damage to SiC. Neutrons interact with matter primarily by scattering off nuclei, an event which suddenly imparts energy and momentum to an atom. If enough energy is transferred, this scattering event creates structural damage, such as displacement of the impacted atom from its original position to an interstitial site. We performed quantum molecular dynamics simulations to determine the displacement energy threshold, i.e., the minimum energy transfer required to create damage. To do this, we used the self-consistent Demkov-Ortega-Grumbach-Sankey (DOGS) extension(A. A. Demkov et al.), Phys. Rev. B 52, 1618 (1995). of the Harris-functional local orbital LDA method of Sankey et al. In order to benchmark the quality of our methodology for studying radiation damage, we compare our results to those of calculations employing classical interatomic potentials; furthermore, we performed similar simulations for Si, where experimental data exist.

Investigation of amorphization energies for heavy ion implants into silicon carbide at depths far beyond the projected ranges

NASA Astrophysics Data System (ADS)

Friedland, E.

2017-01-01

At ion energies with inelastic stopping powers less than a few keV/nm, radiation damage is thought to be due to atomic displacements by elastic collisions only. However, it is well known that inelastic processes and non-linear effects due to defect interaction within collision cascades can significantly increase or decrease damage efficiencies. The importance of these processes changes significantly along the ion trajectory and becomes negligible at some distance beyond the projected range, where damage is mainly caused by slowly moving secondary recoils. Hence, in this region amorphization energies should become independent of the ion type and only reflect the properties of the target lattice. To investigate this, damage profiles were obtained from α-particle channeling spectra of 6H-SiC wafers implanted at room temperature with ions in the mass range 84 ⩽ M ⩽ 133, employing the computer code DICADA. An average amorphization dose of (0.7 ± 0.2) dpa and critical damage energy of (17 ± 6) eV/atom are obtained from TRIM simulations at the experimentally observed boundary positions of the amorphous zones.

Material Damage System and Method for Determining Same

NASA Technical Reports Server (NTRS)

Okojie, Robert (Inventor)

2017-01-01

A system and method for determining a change in a thickness and temperature of a surface of a material are disclosed herein. The system and the method are usable in a thermal protection system of a space vehicle, such as an aeroshell of a space vehicle. The system and method may incorporate micro electric sensors arranged in a ladder network and capacitor strip sensors. Corrosion or ablation causes a change in an electrical property of the sensors. An amount of or rate of the corrosion or the ablation and a temperature of the material is determined based on the change of the electrical property of the sensors.

Long-term temperature effects on GaAs solar cells

NASA Technical Reports Server (NTRS)

Heinbockel, J. H.; Hong, K. H.

1979-01-01

The thermal degradation of AlGaAs solar cells resulting from a long-term operation in a space environment is investigated. The solar cell degradation effects caused by zinc and aluminum diffusion as well as deterioration by arsenic evaporation are presented. Also, the results are presented of experimental testing and measurements of various GaAs solar cell properties while the solar cell was operating in the temperature range of 27 C to 350 C. In particular, the properties of light current voltage curves, dark current voltage curves, and spectral response characteristics are given. Finally, some theoretical models for the annealing of radiation damage over various times and temperatures are included.

Advances in using satellite altimetry to observe storm surge

NASA Astrophysics Data System (ADS)

Han, Guoqi

2017-04-01

Storm surges are the major cause for coastal flooding, resulting in catastrophic damage to properties and loss of life in coastal communities. Thus it is important to utilize new technology to enhance our capabilities of observing storm surges and ultimately to improve our capacity for forecasting storm surges and mitigating damage and loss. In this talk we first review traditional methods of monitoring storm surges. We then provide examples of storm surges observed by nadir satellite altimetry, during Hurricane Sandy and Igor, as well as typhoon and cyclone events. We further evaluate satellite results against tide-gauge data and explain storm surge features. Finally, we discuss the potential of a wide-swath altimetry mission, the Surface Water and Ocean Topography (SWOT), for observing storm surges.

Significance of hair-dye base-induced sensory irritation.

PubMed

Fujita, F; Azuma, T; Tajiri, M; Okamoto, H; Sano, M; Tominaga, M

2010-06-01

Oxidation hair-dyes, which are the principal hair-dyes, sometimes induce painful sensory irritation of the scalp caused by the combination of highly reactive substances, such as hydrogen peroxide and alkali agents. Although many cases of severe facial and scalp dermatitis have been reported following the use of hair-dyes, sensory irritation caused by contact of the hair-dye with the skin has not been reported clearly. In this study, we used a self-assessment questionnaire to measure the sensory irritation in various regions of the body caused by two model hair-dye bases that contained different amounts of alkali agents without dyes. Moreover, the occipital region was found as an alternative region of the scalp to test for sensory irritation of the hair-dye bases. We used this region to evaluate the relationship of sensitivity with skin properties, such as trans-epidermal water loss (TEWL), stratum corneum water content, sebum amount, surface temperature, current perception threshold (CPT), catalase activities in tape-stripped skin and sensory irritation score with the model hair-dye bases. The hair-dye sensitive group showed higher TEWL, a lower sebum amount, a lower surface temperature and higher catalase activity than the insensitive group, and was similar to that of damaged skin. These results suggest that sensory irritation caused by hair-dye could occur easily on the damaged dry scalp, as that caused by skin cosmetics reported previously.

Xanthohumol Prevents DNA Damage by Dietary Carcinogens: Results of a Human Intervention Trial.

PubMed

Pichler, Christoph; Ferk, Franziska; Al-Serori, Halh; Huber, Wolfgang; Jäger, Walter; Waldherr, Monika; Mišík, Miroslav; Kundi, Michael; Nersesyan, Armen; Herbacek, Irene; Knasmueller, Siegfried

2017-02-01

Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. In vitro and animal studies indicated that XN has DNA and cancer protective properties. To find out if it causes DNA protective effects in humans, an intervention trial was conducted in which the participants (n = 22) consumed a XN containing drink (12 mg XN/P/d). We monitored prevention of DNA damage induced by representatives of major groups of dietary carcinogens [i.e., nitrosodimethylamine (NDMA) benzo(a)pyrene (B(a)P) and the heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)]. Lymphocytes were collected before, during, and after the intervention and incubated with the carcinogens and with human liver homogenate (S9). We found substantial reduction of B(a)P and IQ (P < 0.001 for both substances) induced DNA damage after consumption of the beverage; also, with the nitrosamine a moderate, but significant protective effect was found. The results of a follow-up trial (n = 10) with XN pills showed that the effects are caused by the flavonoid and were confirmed in γH2AX experiments. To elucidate the underlying mechanisms we measured several parameters of glutathione related detoxification. We found clear induction of α-GST (by 42.8%, P < 0.05), but no alteration of π-GST. This observation provides a partial explanation for the DNA protective effects and indicates that the flavonoid also protects against other carcinogens that are detoxified by α-GST. Taken together, our findings support the assumption that XN has anticarcinogenic properties in humans. Cancer Prev Res; 10(2); 153-60. ©2016 AACR. ©2016 American Association for Cancer Research.

Protecting the radiation-damaged skin from friction: a mini review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herst, Patries M

2014-06-15

Radiation-induced skin reactions are an unavoidable side effect of external beam radiation therapy, particularly in areas prone to friction and excess moisture such as the axilla, head and neck region, perineum and skin folds. Clinical studies investigating interventions for preventing or managing these reactions have largely focussed on formulations with moisturising, anti-inflammatory, anti-microbial and wound healing properties. However, none of these interventions has emerged as a consistent candidate for best practice. Much less emphasis has been placed on evaluating ways to protect the radiation-damaged skin from friction and excess moisture. This mini review analyses the clinical evidence for barrier productsmore » that form a protective layer by adhering very closely to the skin folds and do not cause further trauma to the radiation-damaged skin upon removal. A database search identified only two types of barrier products that fitted these criteria and these were tested in two case series and six controlled clinical trials. Friction protection was most effective when the interventions were used from the start of treatment and continued for several weeks after completion of treatment. Soft silicone dressings (Mepilex Lite and Mepitel Film) and Cavilon No Sting Barrier Film, but not Cavilon Moisturizing Barrier Cream, decreased skin reaction severity, most likely due to differences in formulation and skin build-up properties. It seems that prophylactic use of friction protection of areas at risk could be a worthwhile addition to routine care of radiation-damaged skin.« less

Protecting the radiation-damaged skin from friction: a mini review

PubMed Central

Herst, Patries M

2014-01-01

Radiation-induced skin reactions are an unavoidable side effect of external beam radiation therapy, particularly in areas prone to friction and excess moisture such as the axilla, head and neck region, perineum and skin folds. Clinical studies investigating interventions for preventing or managing these reactions have largely focussed on formulations with moisturising, anti-inflammatory, anti-microbial and wound healing properties. However, none of these interventions has emerged as a consistent candidate for best practice. Much less emphasis has been placed on evaluating ways to protect the radiation-damaged skin from friction and excess moisture. This mini review analyses the clinical evidence for barrier products that form a protective layer by adhering very closely to the skin folds and do not cause further trauma to the radiation-damaged skin upon removal. A database search identified only two types of barrier products that fitted these criteria and these were tested in two case series and six controlled clinical trials. Friction protection was most effective when the interventions were used from the start of treatment and continued for several weeks after completion of treatment. Soft silicone dressings (Mepilex Lite and Mepitel Film) and Cavilon No Sting Barrier Film, but not Cavilon Moisturizing Barrier Cream, decreased skin reaction severity, most likely due to differences in formulation and skin build-up properties. It seems that prophylactic use of friction protection of areas at risk could be a worthwhile addition to routine care of radiation-damaged skin. PMID:26229646

Multilevel modeling of damage accumulation processes in metals

NASA Astrophysics Data System (ADS)

Kurmoiartseva, K. A.; Trusov, P. V.; Kotelnikova, N. V.

2017-12-01

To predict the behavior of components and constructions it is necessary to develop the methods and mathematical models which take into account the self-organization of microstructural processes and the strain localization. The damage accumulation processes and the evolution of material properties during deformation are important to take into account. The heterogeneity of the process of damage accumulation is due to the appropriate physical mechanisms at the scale levels, which are lower than the macro-level. The purpose of this work is to develop a mathematical model for analyzing the behavior of polycrystalline materials that allows describing the damage accumulation processes. Fracture is the multistage and multiscale process of the build-up of micro- and mesodefects over the wide range of loading rates. The formation of microcracks by mechanisms is caused by the interactions of the dislocations of different slip systems, barriers, boundaries and the inclusions of the secondary phase. This paper provides the description of some of the most well-known models of crack nucleation and also suggests the structure of a mathematical model based on crystal plasticity and dislocation models of crack nucleation.

The effect of resin on the impact damage tolerance of graphite-epoxy laminates

NASA Technical Reports Server (NTRS)

Williams, J. G.; Rhodes, M. D.

1981-01-01

The effect of the matrix resin on the impact damage tolerance of graphite-epoxy composite laminates was investigated. The materials were evaluated on the basis of the damage incurred due to local impact and on their ability to retain compression strength in the presence of impact damage. Twenty-four different resin systems were evaluated. Five of the systems demonstrated substantial improvements compared to the baseline system including retention of compression strength in the presence of impact damage. Examination of the neat resin mechanical properties indicates the resin tensile properties influence significantly the laminate damage tolerance and that improvements in laminate damage tolerance are not necessarily made at the expense of room temperature mechanical properties. Preliminary results indicate a resin volume fraction on the order of 40 percent or greater may be required to permit the plastic flow between fibers necessary for improved damage tolerance.

Regional landslide-hazard assessment for Seattle, Washington, USA

USGS Publications Warehouse

Baum, R.L.; Coe, J.A.; Godt, J.W.; Harp, E.L.; Reid, M.E.; Savage, W.Z.; Schulz, W.H.; Brien, D.L.; Chleborad, A.F.; McKenna, J.P.; Michael, J.A.

2005-01-01

Landslides are a widespread, frequent, and costly hazard in Seattle and the Puget Sound area of Washington State, USA. Shallow earth slides triggered by heavy rainfall are the most common type of landslide in the area; many transform into debris flows and cause significant property damage or disrupt transportation. Large rotational and translational slides, though less common, also cause serious property damage. The hundreds of landslides that occurred during the winters of 1995-96 and 1996-97 stimulated renewed interest by Puget Sound communities in identifying landslide-prone areas and taking actions to reduce future landslide losses. Informal partnerships between the U.S. Geological Survey (USGS), the City of Seattle, and private consultants are focusing on the problem of identifying and mapping areas of landslide hazard as well as characterizing temporal aspects of the hazard. We have developed GIS-based methods to map the probability of landslide occurrence as well as empirical rainfall thresholds and physically based methods to forecast times of landslide occurrence. Our methods for mapping landslide hazard zones began with field studies and physically based models to assess relative slope stability, including the effects of material properties, seasonal groundwater levels, and rainfall infiltration. We have analyzed the correlation between historic landslide occurrence and relative slope stability to map the degree of landslide hazard. The City of Seattle is using results of the USGS studies in storm preparedness planning for emergency access and response, planning for development or redevelopment of hillsides, and municipal facility planning and prioritization. Methods we have developed could be applied elsewhere to suit local needs and available data.

A Hypothesis on Biological Protection from Space Radiation Through the Use of Therapeutic Gases

NASA Technical Reports Server (NTRS)

Schoenfeld, Michael

2011-01-01

This slide presentation proposes a hypothesis to use therapeutic gases in space to enhance the biological protection for astronauts from space radiation. The fundamental role in how radiation causes biological damage appears to be radiolysis, the dissociation of water by radiation. A chain of events appears to cause molecular and biological transformations that ultimately manifest into medical diseases. The hypothesis of this work is that applying medical gases may increase resistance to radiation, by possessing the chemical properties that effectively improve the radical scavenging and enhance bond repair and to induce biological processes which enhance and support natural resistance and repair mechanisms.

Combined Effects of Temperature and Irradiation on Concrete Damage

DOE PAGES

Le Pape, Yann; Giorla, Alain; Sanahuja, Julien

2016-01-01

Aggregate radiation-induced volumetric expansion (RIVE) is a predominant mechanism in the formation of mechanical damage in the hardened cement paste (hcp) of irradiated concrete under fast-neutron flux (Giorla et al. 2015). Among the operating conditions difference between test reactors and light water reactors (LWRs), the difference of irradiation flux and temperature is significant. While a temperature increase is quite generally associated with a direct, or indirect (e.g., by dehydration) loss of mechanical properties (Maruyama et al. 2014), we found that it causes a partial annealing of irradiation amorphization of α-quartz, hence, reducing RIVE rate. Based on data collected by Bykovmore » et al. (1981), an incremental RIVE model coupling neutron fluence and temperature is developed. The elastic properties and coefficient of thermal expansion (CTE) of irradiated polycrystalline quartz are interpreted through analytical homogenization of experimental data on irradiated α-quartz published by Mayer and Lecomte (1960). Moreover, the proposed model, implemented in the meso-scale simulation code AMIE, is compared to experimental data obtained on ordinary concrete made of quartz/quartzite aggregate (Dubrovskii et al. 1967). Substantial discrepancy, in terms of damage and volumetric expansion developments, is found when comparing irradiation scenarios assuming constant flux and temperature, as opposed to more realistic test reactor operation conditions.« less

Personal Injury and Property Damage in the Moral Judgments of Children

ERIC Educational Resources Information Center

Elkind, David; Dabek, Ruth F.

1977-01-01

A total of 72 elementary school students responded to six moral judgment story pairs which corresponded to all the possible combinations of intentionality (intentional/unintentional) and type of damage (personal injury/property damage). (Author/JMB)

Optical and electrical properties of indium tin oxide films near their laser damage threshold [Electrical and optical properties of indium tin oxide films under multi-pulse laser irradiation at 1064 nm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoo, Jae -Hyuck; Lange, Andrew; Bude, Jeff

In this paper, we investigated whether the optical and electrical properties of indium tin oxide (ITO) films are degraded under laser irradiation below their laser ablation threshold. While performing multi-pulse laser damage experiments on a single ITO film (4.7 ns, 1064 nm, 10 Hz), we examined the optical and electrical properties in situ. A decrease in reflectance was observed prior to laser damage initiation. However, under sub-damage threshold irradiation, conductivity and reflectance of the film were maintained without measurable degradation. This indicates that ITO films in optoelectronic devices may be operated below their lifetime laser damage threshold without noticeable performancemore » degradation.« less

Optical and electrical properties of indium tin oxide films near their laser damage threshold [Electrical and optical properties of indium tin oxide films under multi-pulse laser irradiation at 1064 nm

DOE PAGES

Yoo, Jae -Hyuck; Lange, Andrew; Bude, Jeff; ...

2017-02-10

In this paper, we investigated whether the optical and electrical properties of indium tin oxide (ITO) films are degraded under laser irradiation below their laser ablation threshold. While performing multi-pulse laser damage experiments on a single ITO film (4.7 ns, 1064 nm, 10 Hz), we examined the optical and electrical properties in situ. A decrease in reflectance was observed prior to laser damage initiation. However, under sub-damage threshold irradiation, conductivity and reflectance of the film were maintained without measurable degradation. This indicates that ITO films in optoelectronic devices may be operated below their lifetime laser damage threshold without noticeable performancemore » degradation.« less

Sustained water-level changes caused by damage and compaction induced by teleseismic earthquakes

NASA Astrophysics Data System (ADS)

Shalev, Eyal; Kurzon, Ittai; Doan, Mai-Linh; Lyakhovsky, Vladimir

2016-07-01

Sustained water-level increase and decrease induced by distant earthquakes were observed in two wells, Gomè 1 and Meizar 1 in Israel. The Gomè 1 well is located within a damage zone of a major fault zone, and Meizar 1 is relatively far from a fault. The monitored pressure change in both wells shows significant water-level oscillations and sustained water-level changes in response to the passage of the seismic waves. The sustained water-level changes include short-term (minutes) undrained behavior and longer-period (hours and days) drained behavior associated with groundwater flow. We model the short-term undrained response of water pressure oscillations and sustained change to the distant 2013 Mw 7.7 Balochistan earthquake by nonlinear elastic behavior of damaged rocks, accounting for small wave-induced compaction and damage accumulation. We suggest that the rocks are close to failure in both locations and strain oscillations produced by the passing seismic waves periodically push the rock above the yield cap, creating compaction when volumetric strain increases and damage when shear strain increases. Compaction increases pore pressure, whereas damage accumulation decreases pore pressure by fracture dilation. The dominant process depends on the properties of the rock. For highly damaged rocks, dilatancy is dominant and a sustained pressure decrease is expected. For low-damage rocks, compaction is the dominant process creating sustained water-level increase. We calculate damage and porosity changes associated to the Balochistan earthquake in both wells and quantify damage accumulation and compaction during the passage of the seismic waves.

Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy.

PubMed

Nweke, Mauryn C; Turmaine, Mark; McCartney, R Graham; Bracewell, Daniel G

2017-03-01

The drying of chromatography resins prior to scanning electron microscopy is critical to image resolution and hence understanding of the bead structure at sub-micron level. Achieving suitable drying conditions is especially important with agarose-based chromatography resins, as over-drying may cause artefact formation, bead damage and alterations to ultrastructural properties; and under-drying does not provide sufficient resolution for visualization under SEM. This paper compares and contrasts the effects of two drying techniques, critical point drying and freeze drying, on the morphology of two agarose based resins (MabSelect™/d w ≈85 µm and Capto™ Adhere/d w ≈75 µm) and provides a complete method for both. The results show that critical point drying provides better drying and subsequently clearer ultrastructural visualization of both resins under SEM. Under this protocol both the polymer fibers (thickness ≈20 nm) and the pore sizes (diameter ≈100 nm) are clearly visible. Freeze drying is shown to cause bead damage to both resins, but to different extents. MabSelect resin encounters extensive bead fragmentation, whilst Capto Adhere resin undergoes partial bead disintegration, corresponding with the greater extent of agarose crosslinking and strength of this resin. While freeze drying appears to be the less favorable option for ultrastructural visualization of chromatography resin, it should be noted that the extent of fracturing caused by the freeze drying process may provide some insight into the mechanical properties of agarose-based chromatography media. © 2017 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation de l'effet structurel de l'impact d'un micrometeorite ou d'un debris orbital sur le bras Canadien 2

NASA Astrophysics Data System (ADS)

Lanouette, Anne-Marie

Space structures are more and more likely to be impacted at hypervelocities, velocities greater than 3km/s, as the number of orbital debris has rapidly grown in the last two decades. These debris are mostly composed of pieces jettisoned from a launcher or a satellite during the deployment of a structure, dead spacecrafts and fragmentation debris. Collision between two debris, generating many smaller new debris, are more likely to happen. Large space debris (diameter over 10cm) are tracked by different space organizations and their position at all time is known. It is however impossible to track the smaller debris while several studies have already demonstrated that they can also cause significant damage to structures. It is now more and more common to add a kind of protection against collisions to the space structures, but the great majority of space structures currently in orbit, as the Canadarm2, are not protected against hypervelocity impacts. Damage caused by such impacts to different space materials such as aluminum, sandwich panels and laminates has already been characterized during different studies since the end of the 1980s while no study, dedicated to the experimental evaluation of the mechanical properties of a space structure after an impact, relevant to the case of the Canadarm2, has been published. It is only possible to find, in the literature, studies determining the residual mechanical properties after an impact at much lower velocities; the energy of impact is generally three orders of magnitude smaller. The Canadarm2, or Space Station Remote Manipulator System (SSRMS), is installed on the International Space Station (ISS) since 2001. It had an initial 10-year lifespan, but it is still very useful today for maintenance operations and to capture and release incoming space capsules. Understanding the effects of an orbital debris impact on the Canadarm2 structure is now primordial in order to adequately redefine the load levels that can be applied on the arm as a function of the observable damage on the thermal blankets. The main objectives of this study are: first, to obtain a correlation between the visible damage on the booms and the corresponding internal damage of the structure, second to study the cracks caused by the impact growth under different cyclic loads, and finally to provide considerations on the load levels to be applied on the robotic arm as a function of the observable damage. To achieve these objectives, samples representative of the Canadarm2 structure, four cylindrical samples of carbon fibers IM7/PEEK with an external diameter of 35cm and a thickness of 2.7mm, were obtained and covered by pieces of thermal blankets also representative of the Canadarm2. These four samples were impacted at the University of New Brunswick hypervelocity facility, HIT Dynamics. Two samples were impacted by projectiles 5.556mm in diameter and the two remaining samples were impacted with 7.938mm in diameter projectiles. All projectiles were aluminum spheres travelling at ˜7km/s. The samples underwent ultrasonic scanning thereafter to obtain images of their internal damage. In the case of the 5.556mm diameter projectiles, the damage left on the front side was an entry crater 6.2cm in diameter on the thermal blanket and a crater 14.8mm in diameter on the composite wall accompanied by no visual damage on the opposite side of the cylinder. In the case of the 7.938mm diameter projectiles, the damage left on the front side was an entry crater 9.2cm in diameter on the thermal blanket and a crater 17.0mm in diameter on the composite wall accompanied by visible damage on the opposite side in a zone 25.5cm in diameter. The suggestions given for the utilization of the Canadarm2 after an impact are thus the followings. If a crater ≤ 14mm on the composite wall is visible on one side accompanied by no damage on the opposite side of the structure, then the flight and emergency load levels can be maintained. However, if a crater ≤ 17.0mm on the composite wall is visible on one side accompanied by damage in a zone ≤ 25.5cm on the opposite side of the cylinder, only the flight load level can still be used for any position of the damaged zones. If the emergency level must be used, then the damaged zones must absolutely be positioned close to the bending neutral plan, otherwise the applied loads will aggravate the damage caused by the orbital debris impact. (Abstract shortened by ProQuest.).

Development and Testing of PRD-66 Hot Gas Filters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambers, J.A.; Garnier, J.E.; McMahon, T. J.

1996-12-31

The overall objective of this program is to develop and commercialize PRD-66 hot gas filters for application in pressurized fluidized bed combustors (PFBC) and Integrated Gas Combined Cycle (IGCC) power generation systems. The work is being carried out in phases with the following specific objectives: 1. Demonstrate acceptable mechanical, chemical, and filtration properties in exposure tests. 2. Produce and qualify selected prototype design filter elements in high temperature high pressure (HTHP) simulated PFBC exposure tests. 3. (Option) Generate a manufacturing plan to support commercial scale-up. 4. (Option) Recommend process equipment upgrades and produce 50 candle filters. Since the beginning ofmore » this program, a parallel evaluation of DuPont Lanxide Composites Inc. (DLC) PRD-66 hot gas candle filters took place using AEP`s TIDD PFBC facility. Several PRD-66 filters experienced damage during the final testing phase at TIDD, after highly successful testing in earlier runs. During the past year, DLC has undertaken a study under this contract to understand the mechanism of damage sustained in TIDD Test Segment 5. DLC has formulated a hypothesis for the damage mechanism based on the available evidence, and verified that the damage mechanism is possible given the conditions known to exist in TIDD. Improvements to the filter design to eliminate the root cause of the failure have been undertaken. This report details DLC`s conclusions regarding the failure mechanism, the evidence supporting the conclusions, and steps being taken to eliminate the root cause.« less

A study on the dynamic behavior of the Meuse/Haute-Marne argillite

NASA Astrophysics Data System (ADS)

Cai, M.; Kaiser, P. K.; Suorineni, F.; Su, K.

Excavation of underground tunnels can be conducted by tunnel boring machines (TBM) or drill-and-blast. TBMs cause minimum damage to excavation walls. Blasting effects on excavation walls depend on the care with which the blasting is executed. For blast-induced damage in excavation walls, two issues have to be addressed: rate of loss of confinement (rate of excavation) and dynamic loading from wave propagation that causes both intended and unintended damage. To address these two aspects, laboratory dynamic tests were conducted for the determination of the dynamic properties of the Meuse/Haute-Marne argillite. In the present study, 17 tensile (Brazilian) and 15 compression split Hopkinson pressure bar (SHPB) tests were conducted. The test revealed that the dynamic strengths of the argillite are strain rate dependent. The average dynamic increase factors (ratio of dynamic strength to static strength) for tensile and compressive strength are about 3.3 and 2.4, respectively. A high-speed video camera was used to visualize the initiation of failure and subsequent deformation of the specimens. The direct compression specimens were found to deform and fail uniformly around the circumference of the specimen, by a spalling process. The SHPB Brazilian tests indicated that failure occurred in tension along the line of load application. Radial fractures were also observed. The test results can be used for the development of a dynamic constitutive model for the argillite for the prediction of damage in underground excavation utilizing the drill-and blast method.

Cytotoxicity of mequindox and its metabolites in HepG2 cells in vitro and murine hepatocytes in vivo.

PubMed

Liu, Yingchun; Jiang, Wei; Chen, Yongjun; Liu, Yanyan; Zeng, Peng; Xue, Feiqun; Wang, Quan

2016-02-01

Mequindox, a quinoxaline 1,4-dioxide, is widely used as a feed additive in the Chinese livestock industry because of its effective antibacterial properties. Many recent studies have found that mequindox is rapidly metabolized to numerous metabolites following administration to animals. There have, however, been few reports describing the cytotoxicity of mequindox metabolites. In this study, HepG2 cells were treated with mequindox (0, 2, 10, 50 or 100 μg/ml) or its major metabolites (0, 40, 100, 250 or 500 μg/ml) for 24h. Mice were administrated with mequindox (0, 50, 200 or 500 mg/kg.bw) for five days. DNA damage in the HepG2 cells and mouse hepatocytes was then assessed using an SCGE assay. The cell cycle of the HepG2 cells was also determined by flow cytometry. Mequindox was found to induce cell cycle arrest to the G2/M phase and cause dose-dependent DNA damage in HepG2 cells in vitro and in murine hepatocytes in vivo. Compared with mequindox, the major metabolites had much smaller effects on the cell cycle and caused much less DNA damage in HepG2 cells. And the results indicated that the process of metabolites formed by reduction of the MEQ acetyl group or reduction of the N → O groups could contribute to DNA damage in murine hepatocytes in vivo. Copyright © 2016 Elsevier B.V. All rights reserved.

Lycopene and male infertility

PubMed Central

Durairajanayagam, Damayanthi; Agarwal, Ashok; Ong, Chloe; Prashast, Pallavi

2014-01-01

Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inflicted on spermatozoa. It is postulated that lycopene may have other beneficial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility—lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4–8 mg of lycopene daily for 3–12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. PMID:24675655

41 CFR 101-39.406 - Responsibility for damages.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Responsibility for damages. 101-39.406 Section 101-39.406 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR...

41 CFR 101-39.406 - Responsibility for damages.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Responsibility for damages. 101-39.406 Section 101-39.406 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR...

Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

PubMed Central

Weidinger, Adelheid; Kozlov, Andrey V.

2015-01-01

In the past, reactive oxygen and nitrogen species (RONS) were shown to cause oxidative damage to biomolecules, contributing to the development of a variety of diseases. However, recent evidence has suggested that intracellular RONS are an important component of intracellular signaling cascades. The aim of this review was to consolidate old and new ideas on the chemical, physiological and pathological role of RONS for a better understanding of their properties and specific activities. Critical consideration of the literature reveals that deleterious effects do not appear if only one primary species (superoxide radical, nitric oxide) is present in a biological system, even at high concentrations. The prerequisite of deleterious effects is the formation of highly reactive secondary species (hydroxyl radical, peroxynitrite), emerging exclusively upon reaction with another primary species or a transition metal. The secondary species are toxic, not well controlled, causing irreversible damage to all classes of biomolecules. In contrast, primary RONS are well controlled (superoxide dismutase, catalase), and their reactions with biomolecules are reversible, making them ideal for physiological/pathophysiological intracellular signaling. We assume that whether RONS have a signal transducing or damaging effect is primarily defined by their quality, being primary or secondary RONS, and only secondly by their quantity. PMID:25884116

Operational Forecasting and Warning systems for Coastal hazards in Korea

NASA Astrophysics Data System (ADS)

Park, Kwang-Soon; Kwon, Jae-Il; Kim, Jin-Ah; Heo, Ki-Young; Jun, Kicheon

2017-04-01

Coastal hazards caused by both Mother Nature and humans cost tremendous social, economic and environmental damages. To mitigate these damages many countries have been running the operational forecasting or warning systems. Since 2009 Korea Operational Oceanographic System (KOOS) has been developed by the leading of Korea Institute of Ocean Science and Technology (KIOST) in Korea and KOOS has been operated in 2012. KOOS is consists of several operational modules of numerical models and real-time observations and produces the basic forecasting variables such as winds, tides, waves, currents, temperature and salinity and so on. In practical application systems include storm surges, oil spills, and search and rescue prediction models. In particular, abnormal high waves (swell-like high-height waves) have occurred in the East coast of Korea peninsula during winter season owing to the local meteorological condition over the East Sea, causing property damages and the loss of human lives. In order to improve wave forecast accuracy even very local wave characteristics, numerical wave modeling system using SWAN is established with data assimilation module using 4D-EnKF and sensitivity test has been conducted. During the typhoon period for the prediction of sever waves and the decision making support system for evacuation of the ships, a high-resolution wave forecasting system has been established and calibrated.

Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity.

PubMed

Shimura, Hideki; Tanaka, Ryota; Shimada, Yoshiaki; Yamashiro, Kazuo; Hattori, Nobutaka; Urabe, Takao

2017-11-22

Peptides with cytoprotective functions, including antioxidants and anti-infectives, could be useful therapeutics. Carnosine, β-alanine-histidine, is a dipeptide with anti-oxidant properties. Tripeptides of Ala-His-Lys, Pro-His-His, or Tyr-His-Tyr are also of interest in this respect. We synthesized several histidine-containing peptides including glycine or alanine, and tested their cytoprotective effects on hydrogen peroxide toxicity for PC12 cells. Of all these peptides (Gly-His-His, Ala-His-His, Ala-His-Ala, Ala-Ala-His, Ala-Gly-His, Gly-Ala-His (GAH), Ala-His-Gly, His-Ala-Gly, His-His-His, Gly-His-Ala, and Gly-Gly-His), GAH was found to have the strongest cytoprotective activity. GAH decreased lactate dehydrogenase (LDH) leakage, apoptosis, morphological changes, and nuclear membrane permeability changes against hydrogen peroxide toxicity in PC12 cells. The cytoprotective activity of GAH was superior to that of carnosine against hydrogen peroxide toxicity in PC12 cells. GAH also protected PC12 cells against damage caused by actinomycin D and staurosporine. Additionally, it was found that GAH also protected SH-SY5Y and Jurkat cells from damage caused by hydrogen peroxide, as assessed by LDH leakage. Thus, a novel tripeptide, GAH, has been identified as having broad cytoprotective effects against hydrogen peroxide-induced cell damage.

Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract

PubMed Central

THAM, CHING S.; CHAKRAVARTHI, SRIKUMAR; HALEAGRAHARA, NAGARAJA; DE ALWIS, RANJIT

2013-01-01

Lead causes damage to the body by inducing oxidative stress. The sites of damage include the bone marrow, where marrow hypoplasia and osteosclerosis may be observed. Leaves of Carica papaya, which have antioxidant and haemopoietic properties, were tested against the effect of lead acetate in experimental rats. The rats were divided into 8 groups; control, lead acetate only, Carica papaya (50 mg and 200 mg), post-treatment with Carica papaya (50 mg and 200 mg) following lead acetate administration and pre-treatment with Carica papaya (50 mg and 200 mg) followed by lead acetate administration. The substances were administered for 14 days. The effects were evaluated by measuring protein carbonyl content (PCC) and glutathione content (GC) in the bone marrow. Histological changes in the bone marrow were also observed. The results showed that Carica papaya induced a significant reduction in the PCC activity and significantly increased the GC in the bone marrow. Carica papaya also improved the histology of the bone marrow compared with that of the lead acetate-treated group. In summary, Carica papaya was effective against the oxidative damage caused by lead acetate in the bone marrow and had a stimulatory effect on haemopoiesis. PMID:23403524

Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract.

PubMed

Tham, Ching S; Chakravarthi, Srikumar; Haleagrahara, Nagaraja; DE Alwis, Ranjit

2013-02-01

Lead causes damage to the body by inducing oxidative stress. The sites of damage include the bone marrow, where marrow hypoplasia and osteosclerosis may be observed. Leaves of Carica papaya, which have antioxidant and haemopoietic properties, were tested against the effect of lead acetate in experimental rats. The rats were divided into 8 groups; control, lead acetate only, Carica papaya (50 mg and 200 mg), post-treatment with Carica papaya (50 mg and 200 mg) following lead acetate administration and pre-treatment with Carica papaya (50 mg and 200 mg) followed by lead acetate administration. The substances were administered for 14 days. The effects were evaluated by measuring protein carbonyl content (PCC) and glutathione content (GC) in the bone marrow. Histological changes in the bone marrow were also observed. The results showed that Carica papaya induced a significant reduction in the PCC activity and significantly increased the GC in the bone marrow. Carica papaya also improved the histology of the bone marrow compared with that of the lead acetate-treated group. In summary, Carica papaya was effective against the oxidative damage caused by lead acetate in the bone marrow and had a stimulatory effect on haemopoiesis.

Murine liver damage caused by exposure to nano-titanium dioxide

NASA Astrophysics Data System (ADS)

Hong, Jie; Zhang, Yu-Qing

2016-03-01

Due to its unique physiochemical properties, nano-titanium dioxide (nano-TiO2) is widely used in all aspects of people’s daily lives, bringing it into increasing contact with humans. Thus, this material’s security issues for humans have become a heavily researched subject. Nano-TiO2 can enter the body through the mouth, skin, respiratory tract or in other ways, after which it enters the blood circulation and is deposited in the liver, changing biochemical indicators and causing liver inflammation. Meanwhile, the light sensitivity of these nanoparticles allows them to become media-generating reactive oxygen species (ROS), causing an imbalance between oxidation and anti-oxidation that leads to oxidative stress and liver damage. Nano-TiO2 can be transported into cells via phagocytosis, where the nanoparticles bind to the mitochondrial membrane, resulting in the disintegration of the membrane and the electron transport chain within the mitochondria. Thus, more ROS are produced. Nano-TiO2 can also enter the nucleus, where it can directly embed into or indirectly affect DNA, thereby causing DNA breakage or affecting gene expression. These effects include increased mRNA and protein expression levels of inflammation-related factors and decreased mRNA and protein expression levels of IκB and IL-2, resulting in inflammation. Long-term inflammation of the liver causes HSC cell activation, and extracellular matrix (ECM) deposition is promoted by multiple signalling pathways, resulting in liver fibrosis. In this paper, the latest progress on murine liver injury induced by environmental TiO2 is systematically described. The toxicity of nano-TiO2 also depends on size, exposure time, surface properties, dosage, administration route, and its surface modification. Therefore, its toxic effects in humans should be studied in greater depth. This paper also provides useful reference information regarding the safe use of nano-TiO2 in the future.

The SAFRR tsunami scenario: improving resilience for California

USGS Publications Warehouse

Ross, Stephanie L.; Jones, Lucile M.; Miller, Kevin H.; Porter, Keith A.; Wein, Anne; Wilson, Rick I.; Bahng, Bohyun; Barberopoulou, Aggeliki; Borrero, Jose C.; Brosnan, Deborah M.; Bwarie, John T.; Geist, Eric L.; Johnson, Laurie A.; Kirby, Stephen H.; Knight, William R.; Long, Kate; Lynett, Patrick; Mortensen, Carl E.; Nicolsky, Dmitry J.; Perry, Suzanne C.; Plumlee, Geoffrey S.; Real, Charles R.; Ryan, Kenneth; Suleimani, Elena; Thio, Hong Kie; Titov, Vasily V.; Whitmore, Paul M.; Wood, Nathan J.

2013-01-01

On March 11, 2011, the Tohoku earthquake and the resulting tsunami devastated Japan with a disaster of unfathomable proportions. Five thousand miles away, the waves from Tohoku caused $50 to 100 million in damages in California. Although this pales in comparison to the loss of lives and property in Japan, the U.S. Government must ask whether California, and the national economy, will someday face worse consequences from other distant-source tsunamis. Unfortunately, the answer is “yes.”

Tsunami Defense Efforts at Samcheok Port, Korea

NASA Astrophysics Data System (ADS)

Cho, Y. S.

2016-02-01

Tsunamis mainly triggered by impulsive undersea motions are long waves and can propagate a long distance. Thus, they can cause huge casualties not only neighboring countries but also distant countries. Recently, several devastating tsunamis have been occurred around the Pacific Ocean rim. Among them, the Great East Japan tsunami occurred on March 11, 2011 is probably recorded as one of the most destructive tsunamis during last several decades. The Tsunami killed more than 20,000 people (including missing people) and deprived of property damage of approximately 300 billion USD. The eastern coast of the Korean Peninsula has been attacked historically by unexpected tsunami events. These tsunamis were generated by undersea earthquakes occurred off the west coast of Japan. For example, the Central East Sea Tsunami occurred on May 26, 1983 killed 3 people and caused serious property damage at Samcheok Port located at the eastern coast of Korea. Thus, a defense plan against unexpected tsunami strikes is an essential task for the port authority to protect lives of human beings and port facilities. In this study, a master plan of tsunami defense is introduced at Samcheok Port. A tsunami hazard map is also made by employing both propagation and inundation models. Detailed defense efforts are described including the procedure of development of a tsunami hazard map. Keywords: tsunami, hazard map, run-up height, emergency action plan

Comparing simulations and test data of a radiation damaged CCD for the Euclid mission

NASA Astrophysics Data System (ADS)

Skottfelt, Jesper; Hall, David; Gow, Jason; Murray, Neil; Holland, Andrew; Prod'homme, Thibaut

2016-07-01

The radiation damage effects from the harsh radiative environment outside the Earth's atmosphere can be a cause for concern for most space missions. With the science goals becoming ever more demanding, the requirements on the precision of the instruments on board these missions also increases, and it is therefore important to investigate how the radiation induced damage affects the Charge-Coupled Devices (CCDs) that most of these instruments rely on. The primary goal of the Euclid mission is to study the nature of dark matter and dark energy using weak lensing and baryonic acoustic oscillation techniques. The weak lensing technique depends on very precise shape measurements of distant galaxies obtained by a large CCD array. It is anticipated that over the 6 year nominal lifetime of mission, the CCDs will be degraded to an extent that these measurements will not be possible unless the radiation damage effects are corrected. We have therefore created a Monte Carlo model that simulates the physical processes taking place when transferring signal through a radiation damaged CCD. The software is based on Shockley-Read-Hall theory, and is made to mimic the physical properties in the CCD as close as possible. The code runs on a single electrode level and takes charge cloud size and density, three dimensional trap position, and multi-level clocking into account. A key element of the model is that it takes device specific simulations of electron density as a direct input, thereby avoiding to make any analytical assumptions about the size and density of the charge cloud. This paper illustrates how test data and simulated data can be compared in order to further our understanding of the positions and properties of the individual radiation-induced traps.

49 CFR 1242.16 - Road property damaged-other (account XX-19-48).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Road property damaged-other (account XX-19-48... Structures § 1242.16 Road property damaged—other (account XX-19-48). Separate common expenses in proportion... accounts: Road Property Damaged—Running (XX-17-48) Road Property Damaged—Switching (XX-18-48) ...

Dielectric Characteristics of Microstructural Changes and Property Evolution in Engineered Materials

NASA Astrophysics Data System (ADS)

Clifford, Jallisa Janet

Heterogeneous materials are increasingly used in a wide range of applications such as aerospace, civil infrastructure, fuel cells and many others. The ability to take properties from two or more materials to create a material with properties engineered to needs is always very attractive. Hence heterogeneous materials are evolving into more complex formulations in multiple disciplines. Design of microstructure at multiple scales control the global functional properties of these materials and their structures. However, local microstructural changes do not directly cause a proportional change to the global properties (such as strength and stiffness). Instead, local changes follow an evolution process including significant interactions. Therefore, in order to understand property evolution of engineered materials, microstructural changes need to be effectively captured. Characterizing these changes and representing them by material variables will enable us to further improve our material level understanding. In this work, we will demonstrate how microstructural features of heterogeneous materials can be described quantitatively using broadband dielectric spectroscopy (BbDS). The frequency dependent dielectric properties can capture the change in material microstructure and represent these changes in terms of material variables, such as complex permittivity. These changes in terms of material properties can then be linked to a number of different conditions, such as increasing damage due to impact or fatigue. Two different broadband dielectric spectroscopy scanning modes are presented: bulk measurements and continuous scanning to measure dielectric property change as a function of position across the specimen. In this study, we will focus on ceramic materials and fiber reinforced polymer matrix composites as test bed material systems. In the first part of the thesis, we will present how different micro-structural design of porous ceramic materials can be captured quantitatively using BbDS. These materials are typically used in solid oxide fuel cells (SOFC). Results show significant effect of microstructural design on material properties at multiple temperatures (up to 800 °C). In the later part of the thesis, we will focus on microstructural changes of fiber reinforced composite materials due to impact and static loading. The changes in dielectric response can then be linked to the bulk mechanical properties of the material and various damage modes. Observing trends in dielectric response enables us to further determine local mechanisms and distribution of properties throughout the damaged specimens. A 3D X-ray microscope and a digital microscope have been used to visualize these changes in material microstructure and validate experimental observations. The increase in damage observed in the material microstructure can then also be linked to the changes in dielectric response. Results show that BbDS is an extremely useful tool for identifying microstructural changes within a heterogeneous material and particularly useful in relating remaining properties. Dielectric material variables can be used directly in property degradation laws and help develop a framework for future predictive modeling methodologies.

Effects of Deadly California Debris Flows Seen in Before/After Images from NASA's UAVSAR

NASA Image and Video Library

2018-02-12

Extreme winter rains in January 2018 following the Thomas Fire in Ventura and Santa Barbara Counties caused severe debris flows, resulting in significant loss of life and considerable property damage in the town on Montecito, just east of Santa Barbara. NASA's Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) airborne radar platform detected changes caused by the debris flows between two images acquired on Nov. 2, 2017, and Feb. 5, 2018. An enhanced image pair (top left) shows disturbed areas in orange. In areas of severe surface disruption from the fire scar and debris flows the two image pairs can't be matched and decorrelate (top right). In the middle panels, the radar images are overlaid on the structure damage map produced by the County of Santa Barbara. The fire scars and damage correspond well with the risk map (lower left) and damage map (lower right). With an operational system, products such as these have the potential to augment information available for search and rescue, and for damage assessment for government agencies or the insurance industry. Radar has the advantage of being available in all weather conditions, as it can image through clouds. NASA's Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR), developed and managed by the Jet Propulsion Laboratory, Pasadena, California, can record changes on the ground beneath the aircraft that occur between multiple flights, which take exactly the same flight path. The instrument is used to monitor how volcanoes, earthquakes, and other natural hazards are changing Earth. The JPL UAVSAR team collected and processed the imagery for Principal Investigator Andrea Donnellan who performed the analysis. She has been conducting ground change research using UAVSAR in this and other regions of California since 2009. https://photojournal.jpl.nasa.gov/catalog/PIA22243

Hepatoprotective activity of sea cucumber Phyllophorus sp. extract in carp (Cyprinus carpio)

NASA Astrophysics Data System (ADS)

Sulmartiwi, Laksmi; Triastuti, Juni; Andriyono, Sapto; Umami, Mardiah Rahma

2017-02-01

Many procedures continuously in aquaculture and scientific research like tagging and vaccinating cause pain, involving damaging tissue and also cause stress responses in fish. Stress responses in fish influence liver because liver have vital role to supply energy and metabolism. Histology alteration in liver is caused by stress response like changes of vacuolation hepatocyte and characteristic colour. Triterpenoid was known had hepatoprotective activity. One of marine organism contained triterpenoid was sea cucumber. Result of research showed that liver tissue in fish with injected acetic acid 5 % (in upper lip) as pain stimulus have histopathology damages such as pyknosis (medium damage level) and oedema (heavy damage level) after 8 hour injection. Injected Lidocaine 1mg/fish as analgesic drug have histopathology damages such as oedema (heavy damages level), necrosis and pyknosis (low damages level). Injected acetic acid 5 % (in upper lip) and ethanolic extract of sea cucumber Phyllophorus sp. dose 5 mg/50 gr body weight shown histopathology damages such as necrosis, edema (medium damage level) and pyknosis (low damage level).

Effects of the earthquake of March 27, 1964, on the communities of Kodiak and nearby islands: Chapter F in The Alaska earthquake, March 27, 1964: effects on communities

USGS Publications Warehouse

Kachadoorian, Reuben; Plafker, George

1967-01-01

The great earthquake (Richter magnitude of 8.4–8.5) that struck south-central Alaska at 5:36 p.m., Alaska standard time, on March 27, 1964 (03:36, March 28, Greenwich mean time), was felt in every community on Kodiak Island and the nearby islands. It was the most severe earthquake to strike this part of Alaska in modern time, and took the lives of 18 persons in the area by drowning; this includes two in Kodiak and three at Kaguyak. Property damage and loss of income to the communities is estimated at more than $45 million. The largest community, Kodiak, had the greatest loss from the earthquake. Damage was caused chiefly by 5.6 feet of tectonic subsidence and a train of 10 seismic sea waves that inundated the low-lying areas of the town. The seismic sea waves destroyed all but one of the docking facilities and more than 215 structures; many other structures were severely damaged. The waves struck the town during the evening hours of March 27 and early morning hours of March 28. They moved from the southwest and northeast: and reached their maximum height of 20–30 feet above mean lower low water at Shahafka Cove between 11:00 and 11:45 p.m., March 27. The violently destructive seismic sea waves not only severely damaged homes, shops, and naval-station structures but also temporarily crippled the fishing industry in Kodiak by destroying the processing plants and most of the fishing vessels. The waves scoured out 10 feet of sediments in the channel between Kodiak Island and Near Island and exposed bedrock. This bedrock presented a major post-earthquake construction problem because no sediments remained into which piles could be driven for foundations of waterfront facilities. Because of tectonic subsidence, high tides now flood Mission and Potatopatch Lakes which, before the earthquake, had not been subject to tidal action. The subsidence also accelerated erosion of the unconsolidated sediments along the shoreline in the city of Kodiak. Seismic shaking lasted 4½–5½ minutes at Kodiak and had a rolling motion. Inasmuch as most of Kodiak is underlain by bedrock or by only a thin veneer of unconsolidated sediments, very little if any damage occurred from ground motion or seismic shaking. The ground motion, however, did cause a massive short circuit and power failure at Kodiak. The Kodiak Naval Station, 5 miles southwest of Kodiak, was also severely damaged by the earthquake. The station was inundated by at least 10 seismic sea waves which reached a maximum height of 25 feet above post-earthquake mean lower low water between 11:16 and 11:34 p.m. on March 27, 1964. The first seismic sea wave that inundated the station did not do severe damage because it behaved much like a rapid rise of tide, but the subsequent and more violent waves destroyed most of the docking facilities and several other shoreline structures. The waves struck the station from the southwest and from the east. The shoreline structures that were not destroyed required rehabilitation because the 5.6 feet of tectonic subsidence put them under water during the highest tides. Furthermore the subsidence accelerated erosion during high tide of the soft unconsolidated sediments and fill in the low-lying areas of the station. Seismic shaking did little damage to the station housing facility, but it was responsible for compaction of sediments, lateral displacement of a seawall, and the development of fissures in the aircraft parking area. The ground motion was as south-southeast–north-northwest to north-south in direction. An unusual case of radioactive contamination was reported at the naval station. The inundating seismic sea waves entered a building in which radionuclides were stored. The contamination was restricted to the building only, however, and did not spread throughout the station. Afognak was abandoned because of the extensive damage incurred from tectonic subsistence and seismic sea waves. The seismic effects, estimated Mercalli intensity VI-VII, did not directly cause any significant property damage at Afognak Serious long-term damage, however, resulted from tectonic subsidence estimated to be from 3½ to 5½ feet. The subsidence has resulted in rapid erosion of the coast, landward shift and building up of bench berms to the new higher sea levels, and flooding of extensive low-lying areas behind the barrier beaches. Inundation of low-lying parts of the village by a train of seismic sea waves having maximum heights of 10.8 feet above post-earthquake tide level (14.5 ft above post-earthquake mean lower low water) caused losses of about half a million dollars to homes, vehicles, bridges, and personal possessions. Uzinki was damaged by tectonic subsidence and seismic sea waves. No significant damage resulted from the ground motion during the earthquake; the Mercalli intensity was about VI. However, tectonic subsidence, estimated to be 5 feet, caused inundation of a narrow zone along the waterfront. Structures and vessels were damaged as a result of the seismic sea waves that repeatedly flooded the waterfront area after the earthquake. Old Harbor was damaged by seismic shock, subsidence, and seismic sea waves. The tremors, which had a Mercalli intensity estimated at VII-VIII, toppled two concrete-block chimneys, cracked interior walls, and caused minor breakage of personal property in the homes. Regional tectonic subsidence and superficial subsidence of the unconsolidated deposits on which the village is situated apparently caused incursion of salt water into the school well. A quarter of million yards of fill was required to raise the waterfront areas to their pre-earthquake elevations relative to sea level. Seismic sea waves having a maximum runup of about 12 feet above tide level (16 ft above post-earthquake mean lower low water) destroyed 34 of the 35 residences in the village and presumably drowned one man who lived immediately across the strait from Old Harbor. At Kaguyak, seismic sea waves having a maximum runup of about 25 feet above mean lower low water carried away all 10 buildings in the village, took three lives, and damaged an unknown number of fishing vessels. The village site has been abandoned. The communities of Akhiok, Karluk, and Larsen Bay were virtually undamaged by the earthquake tremors, which had estimated Mercalli intensities of VI-VII, but tectonic subsidence of about 2–2½ feet at Larsen Bay made it necessary to raise the cannery dock level at an estimated cost of $80,000.

INHIBITION OF FRIED MEAT-INDUCED DNA DAMAGE: A DIETARY INTERVENTION STUDY IN HUMANS

EPA Science Inventory

Dietary exposures have been implicated as risk factors in colorectal cancer. Such agents may act by causing DNA damage or may be protective against DNA damage. The effects of dietary exposures in causing or preventing damage have not been assessed directly in colon tissues. In th...

Do native parasitic plants cause more damage to exotic invasive hosts than native non-invasive hosts? An implication for biocontrol.

PubMed

Li, Junmin; Jin, Zexin; Song, Wenjing

2012-01-01

Field studies have shown that native, parasitic plants grow vigorously on invasive plants and can cause more damage to invasive plants than native plants. However, no empirical test has been conducted and the mechanism is still unknown. We conducted a completely randomized greenhouse experiment using 3 congeneric pairs of exotic, invasive and native, non-invasive herbaceous plant species to quantify the damage caused by parasitic plants to hosts and its correlation with the hosts' growth rate and resource use efficiency. The biomass of the parasitic plants on exotic, invasive hosts was significantly higher than on congeneric native, non-invasive hosts. Parasites caused more damage to exotic, invasive hosts than to congeneric, native, non-invasive hosts. The damage caused by parasites to hosts was significantly positively correlated with the biomass of parasitic plants. The damage of parasites to hosts was significantly positively correlated with the relative growth rate and the resource use efficiency of its host plants. It may be the mechanism by which parasitic plants grow more vigorously on invasive hosts and cause more damage to exotic, invasive hosts than to native, non-invasive hosts. These results suggest a potential biological control effect of native, parasitic plants on invasive species by reducing the dominance of invasive species in the invaded community.

The effect of thermal damage on the mechanical properties of polymer regrinds

NASA Technical Reports Server (NTRS)

Kundu, Nikhil K.

1990-01-01

Reprocessed polymers are subjected to high processing temperatures that result in the breakdown of molecular chains and changes in the molecular structures. These phenomena are reflected in the mechanical properties of materials. Practically every regrind is seen as a new material. These experiments deal with the molding, regrinding, and reprocessing of test specimens for the study of their mechanical properties. The comparative test data from each recycled material would give students an insight of the molecular structures and property degradation. Three important rheological and mechanical properties such as melt flow, impact strength, and flexural strength are to be determined. These properties play key roles in the selection of engineering materials. The material selected for demonstration was Makrolon 3000L, a polycarbonate thermoplastic from Bayer AG. The thermal degradation due to repeated processing is reflected in the decrease in molecular weight and breakdown of molecular chains causing increase in melt flow. The Izod-impact resistance and the flexural strength deteriorate gradually.

Importance of secondary damage in downer cows.

PubMed

Poulton, P J; Vizard, A L; Anderson, G A; Pyman, M F

2016-05-01

To investigate the relative importance in downer cows of the primary cause of recumbency in comparison with secondary complications. Downer dairy cows were monitored during their recumbency under field conditions in South Gippsland, Victoria, Australia. The cause of the original recumbency of the 218 cows was determined and secondary damage, status on day 7 and final outcome were recorded. Some type of secondary damage was found in 183/218 (84%) cows, of which 173/218 (79%) had damage deemed to be clinically important. By day 7, 52 (24%) had recovered and 69 (32%) eventually recovered. Of the 149 (68%) cows that were euthanased or died, 23 (15%) were deemed to have been lost solely from the primary cause, 107 (72%) from secondary damage and 19 (13%) from a combination of both. There was no difference in recovery among the five broad groups of causes of primary recumbency. Secondary damage was very common and presented in a large variety of ways, with many cows having multiple types of secondary damage concurrently. For most cows the secondary damage was more important than the initial primary damage in determining their fate. © 2016 Australian Veterinary Association.

Analysis of optical properties behaviour of CLEARCERAM, fused silica and CaF2 glasses exposed to simulated space conditions

NASA Astrophysics Data System (ADS)

Fernández-Rodríguez, M.; Alvarado, C. G.; Núñez, A.; Álvarez-Herrero, A.

2017-11-01

Optical instrumentation on-board satellites suffer degradation due to the hostile conditions of space environment. Space conditions produce instrumentation performances changes causing a decrease or a cancellation of their features. Particularly, space environment conditions have a significant influence on the optical properties of glasses which are part of space optical systems. Space environment characteristics which effects on the optical system have to be taken into account are: outgassing, volatile components, gas or water vapor which form part of the spacecraft materials, vacuum, microgravity, micrometeorites, space debris, thermal, mechanical and radiation environment and effects of the high atmosphere [1]. This work is focused on analyzing temperature variations and ultraviolet (UV) and gamma radiation effects on the optical properties of several glasses used on space applications. Thermal environment is composed of radiation from the Sun, the albedo and the Earth radiation and the radiation from the spacecraft to deep space. Flux and influence of temperature on satellite materials depend on factors as the period of year or the position of them on the space system. Taking into account that the transfer mechanisms of heat are limited by the conduction and the radiation, high gradients of temperature are obtained in system elements which can cause changes of their optical properties, birefringence… Also, these thermal cycles can introduce mechanical loads into material structure due to the expansion and the contraction of the material leading to mechanical performances degradation [2]. However, it is the radiation environment the main cause of damage on optical properties of materials used on space instrumentation. This environment consists of a wide range of energetic particles between keV and MeV which are trapped by the geomagnetic field or are flux of particles that cross the Earth environment from the external of the Solar System [3]. The damage produced by the radiation environment on the optical materials can be classified in two types: ionizing or non-ionizing. This damage may produce continual or accumulative (dose) alterations on the optical material performances, or may produce alterations which not remain along the time (transitory effects). The effects of the radiation on optical materials can be summarized on changes of optical transmission and refractive index, variation of density and superficial degradation [4-6]. Two non-invasive and non-destructive techniques such as Optical Spectrum Analyzer and Spectroscopic Ellipsometry [7] have been used to characterize optically the three kinds of studied glasses, CaF2, Fused Silica and Clearceram. The study of the temperature and radiation effects on the glasses optical properties showed that the gamma radiation is the principal responsible of glasses optical degradation. The optical properties of the Clearceram glass have been affected by the gamma irradiation due to the absorption bands induced by the radiation in the visible spectral range (color centers). Therefore, an analysis about the behavior of these color centers with the gamma radiation total dose and with the time after the irradiation has been carried out in the same way that it is performed in [8].

Atmospheric skin aging-Contributors and inhibitors.

PubMed

McDaniel, David; Farris, Patricia; Valacchi, Giuseppe

2018-04-01

Cutaneous aging is a complex biological process consisting of 2 elements: intrinsic aging, which is primarily determined by genetics, and extrinsic aging, which is largely caused by atmospheric factors, such as exposure to sunlight and air pollution, and lifestyle choices, such as diet and smoking. The role of the solar spectrum, comprised of ultraviolet light, specifically UVB (290-320 nm) and UVA (320-400) in causing skin damage, including skin cancers, has been well documented. In recent years, the contribution of visible light (400-700 nm) and infrared radiation (above 800 nm) in causing skin damage, similar to the photodamage caused by UV light, is also being elucidated. In addition, other atmospheric factors such as air pollution (smog, ozone, particulate matter, etc.) have been implicated in premature skin aging. The skin damage caused by environmental exposure is largely attributable to a complex cascade of reactions inside the skin initiated by the generation of reactive oxygen species (ROS), which causes oxidative damage to cellular components such as proteins, lipids, and nucleic acids. These damaged skin cells initiate inflammatory responses leading to the eventual damage manifested in chronically exposed skin. Novel therapeutic strategies to combat ROS species generation are being developed to prevent the skin damage caused by atmospheric factors. In addition to protecting skin from solar radiation using sunscreens, other approaches using topically applied ingredients, particularly antioxidants that penetrate the skin and protect the skin from within, have also been well documented. This review summarizes current knowledge of atmospheric aggressors, including UVA, UVB, visible light, infrared radiation (IR), and ozone on skin damage, and proposes new avenues for future research in the prevention and treatment of premature skin aging caused by such atmospheric factors. New therapeutic modalities currently being developed are also discussed. © 2018 Wiley Periodicals, Inc.

A method to separate and quantify the effects of indentation size, residual stress and plastic damage when mapping properties using instrumented indentation

NASA Astrophysics Data System (ADS)

Hou, X. D.; Jennett, N. M.

2017-11-01

Instrumented indentation is a convenient and increasingly rapid method of high resolution mapping of surface properties. There is, however, significant untapped potential for the quantification of these properties, which is only possible by solving a number of serious issues that affect the absolute values for mechanical properties obtained from small indentations. The three most pressing currently are the quantification of: the indentation size effect (ISE), residual stress, and pile-up and sink-in—which is itself affected by residual stress and ISE. Hardness based indentation mapping is unable to distinguish these effects. We describe a procedure that uses an elastic modulus as an internal reference and combines the information available from an indentation modulus map, a hardness map, and a determination of the ISE coefficient (using self-similar geometry indentation) to correct for the effects of stress, pile up and the indentation size effect, to leave a quantified map of plastic damage and grain refinement hardening in a surface. This procedure is used to map the residual stress in a cross-section of the machined surface of a previously stress free metal. The effect of surface grinding is compared to milling and is shown to cause different amounts of work hardening, increase in residual stress, and surface grain size reduction. The potential use of this procedure for mapping coatings in cross-section is discussed.

A freeze-stable formulation for DTwP and DTaP vaccines.

PubMed

Xue, Honggang; Yang, Bangling; Kristensen, Debra D; Chen, Dexiang

2014-01-01

Inadvertent vaccine freezing often occurs in the cold chain and may cause damage to freeze‑sensitive vaccines. Liquid vaccines that contain aluminum salt adjuvants are particularly vulnerable. Polyol cryoprotective excipients have been shown to prevent freeze damage to hepatitis B vaccine. In this study, we examined the freeze-protective effect of propylene glycol on diphtheria-tetanus-pertussis-whole-cell (DTwP) and acellular (DTaP) vaccines. Pilot lots of DTwP and DTaP formulated with 7.5% propylene glycol underwent 3 freeze-thaw treatments. The addition of propylene glycol had no impact on pH, particle size distribution, or potency of the vaccines prior to freeze-thaw treatment; the only change noted was an increase in osmolality. The potencies and the physical properties of the vaccines containing cryoprotectant were maintained after freeze-thawing and for 3 months in accelerated stability studies. The results from this study indicate that formulating vaccines with propylene glycol can protect diphtheria-tetanus-pertussis vaccines against freeze damages.

Automated Detection of Alkali-silica Reaction in Concrete using Linear Array Ultrasound Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santos-Villalobos, Hector J; Clayton, Dwight A; Ezell, N Dianne Bull

Alkali-silica reaction (ASR) is a chemical reaction in either concrete or mortar between hydroxyl ions of the alkalis (sodium and potassium) from hydraulic cement (or other sources), and certain siliceous minerals present in some aggregates. The reaction product, an alkali-silica gel, is hygroscopic having a tendency to absorb water and swell, which under certain circumstances, leads to abnormal expansion and cracking of the concrete. This phenomenon affects the durability and performance of concrete structures severely since it can cause significant loss of mechanical properties. Developing reliable methods and tools that can evaluate the degree of the ASR damage in existingmore » structures, so that informed decisions can be made toward mitigating ASR progression and damage, is important to the long term operation of nuclear power plants especially if licenses are extended beyond 60 years. This paper examines an automated method of determining the extent of ASR damage in fabricated concrete specimens.« less

Natural Hazards - A National Threat

USGS Publications Warehouse

Geological Survey, U.S.

2007-01-01

The USGS Role in Reducing Disaster Losses -- In the United States each year, natural hazards cause hundreds of deaths and cost billions of dollars in disaster aid, disruption of commerce, and destruction of homes and critical infrastructure. Although the number of lives lost to natural hazards each year generally has declined, the economic cost of major disaster response and recovery continues to rise. Each decade, property damage from natural hazards events doubles or triples. The United States is second only to Japan in economic damages resulting from natural disasters. A major goal of the U.S. Geological Survey (USGS) is to reduce the vulnerability of the people and areas most at risk from natural hazards. Working with partners throughout all sectors of society, the USGS provides information, products, and knowledge to help build more resilient communities.

Rapid annealing of iron implanted Hg(1-x)Cd(x)Te

NASA Astrophysics Data System (ADS)

Kalish, Rafael

1990-03-01

Different Rapid Thermal Annealing techniques were employed to achieve damage removal and electrical activation of dopants in ion implanted Hg(1-x)Cd(x)Te (x = 0.2, 0.3). As seen by Rutherford Backscattering Spectrometry combined with channeling and Auger measurements annealings with a CO2 laser or a flash lamp lead to good removal of implantation damage without causing changes in the stoichiometry. These techniques, however, suffer from complexity and lack of reproducibility. The new simple method for RTA of mercury containing crystals Annealing by immersion in a how MErcury BAth (AMEBA) which was developed within the present project was found to be comparable to other more complicate techniques as for improving the electrical properties of HgCdTe as deduced from Hall and differential Hall measurements.

Tornado-associated fatalities--Arkansas, 1997.

PubMed

1997-05-16

On March 1, 1997, approximately nine tornadoes originating from two separate thunderstorms swept across Arkansas, from Hempstead County in the southwest to Clay County in the northeast (approximately 260 miles). The tornadoes caused 26 deaths and an estimated $115 million in property damage, reflecting damage to residences, nonresidential buildings, bridges, and roads and agriculture and timber losses. The strongest tornadoes touched down southwest of Little Rock in Clark, Saline, and Pulaski counties; the estimated widths of the tornado paths ranged from 1/2 to 1 mile, and wind speeds were > 200 miles per hour (National Weather Service [NWS], unpublished data, 1997). This report summarizes circumstances of the tornado-associated fatalities from information collected by the American Red Cross (ARC); 14 of the 26 fatalities occurred among persons who were in mobile homes.

Squirrel Damage to Pines

Treesearch

USDA Forest Service

1981-01-01

Flagging (dead branch tips) on jack pine and red pine may be caused by insects, diseases, or mechanical damage. In the Lake States, flagging is often the result of mechanical damage, sometimes girdling, caused when the cones are torn off by red squirrels.

Effects of yolk contamination, shearing, and heating on foaming properties of fresh egg white.

PubMed

Wang, G; Wang, T

2009-03-01

A series of experiments were conducted to evaluate effects of yolk contamination, shearing, and thermal treatment on foaming properties of liquid egg white. Samples obtained from industrial processing were also evaluated. Whipping and purging methods were both used to assess their effectiveness and sensitivity in evaluating foaming. A concentration as low as 0.022% (as-is basis) of yolk contamination caused significant reductions in foaming capacity and foaming speed. The neutral lipid fraction of egg yolk caused the major detrimental effect on foaming, and phospholipids fraction did not give significant foaming reduction at a concentration as high as 0.1%. High-speed and short-time shearing caused no apparent damage but longer shearing time significantly impaired foaming. Heat-induced foaming change is a function of temperature and holding time. Foaming was significantly reduced at a temperature of 55 degrees C for 10 min, whereas it did not change up to 3 min at a heating temperature of 62 to 64 degrees C. Industrial processing steps (pumping, pipe transfer, and storage) did not produce negative effects on foaming of the final products and the controlled pasteurization was actually beneficial for good foaming performance. Therefore, yolk contamination of the egg white was the major factor in reducing foaming properties of the white protein.

Legal aspects of sinkhole development and flooding in karst terranes: 1. Review and synthesis

NASA Astrophysics Data System (ADS)

Quinlan, James F.

1986-03-01

Structures built within the area of influence of a sinkhole can be affected by collapse, subsidence, or flooding. Unanticipated property losses may be involved, and litigation commonly ensues. Insurance compensation for damages that result from sinkhole collapse or subsidence in a karst terrane are covered by statute only in Florida and by voluntary agreement of companies operating in Tennessee Liability or insurance compensation for damages resulting from sinkhole flooding is not specifically covered by any state or federal statute. Regulations of the National Flood Insurance Program have been interpreted to allow coverage by this program for homes affected by sinkhole flooding in Bowling Green, Kentucky In the present article, case law, legal concepts of groundwater and surface water, liability, and law review articles relevant to sinkhole litigation are summarized The rationales of plaintiffs and defendants are reviewed Liability for damages have been based on allegations of negligence, breach of various water law doctrines, trespass, nuisance, loss of support, breach of contract, and implied warranty of habitability Defenses against these allegations have been based on the merits of each of them and on caveat emptor Several alternative rationales for claiming liability for losses incurred because of sinkhole development or flooding are proposed and discussed. The little-known Henderson v Wade Sand and Gravel is highly recommended as an alternative leading case that clearly and justifiably gives protection to adjacent landowners, and ties liability for damages caused by groundwater pumpage to nuisance law and related interference with property rights. Several little-known litigated cases of sinkhole development in response to groundwater pumpage will be summarized in a second article at a later date. Concepts of liability are evolving It can be expected that the professional geologist or engineer will have an increasing number of claims made against him or her which allege responsibility for sinkhole-related damages. Such damages can often be prevented by creative zoning, sound engineering, and better husbandry of land.

The role of mechanical properties in cavitation erosion resistance. [parameters affecting metal fatigue under cavitation flow conditions

NASA Technical Reports Server (NTRS)

Gould, G. C.

1974-01-01

Methods for determining the correlations of erosion resistance and mechanical properties of materials are discussed. The most common method of testing cavitation erosion resistance of materials is the vibratory cavitation probe. The instrument and its operation are described. The use of the whirling arm device is considered as a second method. Metallographic investigations of the earliest stages of cavitation erosion damage of metallic materials was conducted. The materials show plastic deformation occurring during the incubation period and increasing until cracks form and metal fragments are lost. The parameters of the work done to cause material fractures are identified. The reactions obtained with specific materials are reported.

32 CFR 751.7 - Claims not payable.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Loss or damage to property to the extent of any available insurance coverage. Except for claims for loss or damage to household goods or privately-owned vehicles (POVS) while shipped or stored at... quality. (h) Loss or damage to property due to negligence of the claimant. Negligence is a failure to...

32 CFR 751.7 - Claims not payable.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Loss or damage to property to the extent of any available insurance coverage. Except for claims for loss or damage to household goods or privately-owned vehicles (POVS) while shipped or stored at... quality. (h) Loss or damage to property due to negligence of the claimant. Negligence is a failure to...

32 CFR 751.7 - Claims not payable.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Loss or damage to property to the extent of any available insurance coverage. Except for claims for loss or damage to household goods or privately-owned vehicles (POVS) while shipped or stored at... quality. (h) Loss or damage to property due to negligence of the claimant. Negligence is a failure to...

32 CFR 751.7 - Claims not payable.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Loss or damage to property to the extent of any available insurance coverage. Except for claims for loss or damage to household goods or privately-owned vehicles (POVS) while shipped or stored at... quality. (h) Loss or damage to property due to negligence of the claimant. Negligence is a failure to...

32 CFR 751.7 - Claims not payable.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Loss or damage to property to the extent of any available insurance coverage. Except for claims for loss or damage to household goods or privately-owned vehicles (POVS) while shipped or stored at... quality. (h) Loss or damage to property due to negligence of the claimant. Negligence is a failure to...

Symposium: Noise-Induced Hearing Loss Held in Beaune, France on 28-30 May 1990.

DTIC Science & Technology

1991-01-01

dehydeogenase (Loll),is a common result of cell damage, and Injury to any Struclture In the cochlea would cause A taumbcr ofbioclienmlcal analyses...threshsold shsft (ITrS) and permanent this transitional stage at which,’the processes threshold shift (PIS) conditions, is a dynamic of repair anid Injury ...properties, hsps can be divided Into several cilia injury in these cases is not known. Mech. families; in eukaryotes there are at least three anisms of

Lightning-Related Indicators for National Climate Assessment (NCA) Studies

NASA Technical Reports Server (NTRS)

Koshak, W.

2017-01-01

Changes in climate can affect the characteristics of lightning (e.g., number of flashes that occur in a region, return stroke current and multiplicity, polarity of charge deposited to ground, and the lightning cloud-top optical energy emission). The NASA/MSFC Lightning Analysis Tool (LAT) monitors these and other quantities in support of the National Climate Assessment (NCA) program. Changes in lightning characteristics lead to changes in lightning-caused impacts to humans (e.g., fatalities, injuries, crop/property damage, wildfires, airport delays, changes in air quality).

Coupled field-structural analysis of HGTR fuel brick using ABAQUS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, S.; Jain, R.; Majumdar, S.

2012-07-01

High-temperature, gas-cooled reactors (HTGRs) are usually helium-gas cooled, with a graphite core that can operate at reactor outlet temperatures much higher than can conventional light water reactors. In HTGRs, graphite components moderate and reflect neutrons. During reactor operation, high temperature and high irradiation cause damage to the graphite crystal and grains and create other defects. This cumulative structural damage during the reactor lifetime leads to changes in graphite properties, which can alter the ability to support the designed loads. The aim of the present research is to develop a finite-element code using commercially available ABAQUS software for the structural integritymore » analysis of graphite core components under extreme temperature and irradiation conditions. In addition, the Reactor Geometry Generator tool-kit, developed at Argonne National Laboratory, is used to generate finite-element mesh for complex geometries such as fuel bricks with multiple pin holes and coolant flow channels. This paper presents the proposed concept and discusses results of stress analysis simulations of a fuel block with H-451 grade material properties. (authors)« less

Extrinsic and intrinsic properties in metal–insulator transition of hydrothermally prepared vanadium dioxide crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Myeongsoon; Kim, Don, E-mail: donkim@pknu.ac.kr

2014-03-01

The clear insulator (monoclinic-VO{sub 2}) to metal (rutile-VO{sub 2}) transition (IMT) was observed in electrical conductivity and differential scanning calorimeter (DSC) measurements at around 340 K, which is IMT temperature (T{sub H}), in the hydrothermally prepared VO{sub 2} crystals. The occurrence of metal to insulator transition (MIT) temperature (T{sub C}) was observed below 333 K during the first resistance measurement cycle in the most of cases. The sudden jump of the electrical resistance at IMT and MIT points was amplified several times than that of the first cycle during the repeated successive thermal cycles (heating and cooling across the IMTmore » and MIT temperatures). T{sub C} and T{sub H} shifted to higher temperature by the repeated successive thermal cycles. This shift and the amplified jump might be related to the mechanical stress between the VO{sub 2} crystals, i.e. extrinsic properties. However, the starting point of MIT, T{sub CS} = ∼ 336 K, and the starting point of IMT, T{sub HS} = ∼ 338 K, kept almost constant during the repeated thermal cycles (< 10 times). These two temperatures may be related to the intrinsic properties of the VO{sub 2}: the phase transitions initiated at these temperatures regardless of the number of the repeated thermal cycles. The neat surface of the VO{sub 2} crystals was severely damaged and the average size of particles reduced from 110 nm to 70–90 nm after extensively repeated thermal cycles (> 70 times). The damaged surface and the smaller particles, which would be originated from the mechanical stress caused by crystal volume change during the first order transition of the VO{sub 2}, would weaken the electrical conduction path (loosen grain boundaries) between the VO{sub 2} single crystals and would result in the amplified jump at the following MIT. This report may boost the study for the improved stability and lifetime of the VO{sub 2} based electronic devices. - Highlights: • The sharp phase transition in cluster of VO{sub 2} crystals depends on repeated thermal cycles. • Two intrinsic and two extrinsic temperatures are observed during the phase transition. • The mechanical stress change and surface damage may cause the extrinsic properties in transport measurement.« less

Light-induced damage and its diagnosis in two-photon excited autofluorescence imaging of retinal pigment epithelium cells

NASA Astrophysics Data System (ADS)

Chen, Danni; Qu, Junle; Xu, Gaixia; Zhao, Lingling; Niu, Hanben

2007-05-01

In this paper, a novel method for the differentiation of the retinal pigment epithelium (RPE) cells after light-induced damage by two-photon excitation is presented. Fresh samples of RPE cells of pig eyes are obtained from local slaughterhouse. Light-induced damage is produced by the output from Ti: sapphire laser which is focused onto the RPE layer. We study the change of the autofluorescence properties of RPE after two-photon excitation with the same wavelength. Preliminary results show that after two-photon excitation, there are two clear changes in the emission spectrum. The first change is the blue-shift of the emission peak. The emission peak of the intact RPE is located at 592nm, and after excitation, it shifts to 540nm. It is supposed that the excitation has led to the increased autofluorescence of flavin whose emission peak is located at 540nm. The second change is the increased intensity of the emission peak, which might be caused by the accelerated aging because the autofluorescence of RPE would increase during aging process. Experimental results indicate that two-photon excitation could not only lead to the damage of the RPE cells in multiphoton RPE imaging, but also provide an evaluation of the light-induced damage.

Role of phenolics from Spondias pinnata bark in amelioration of iron overload induced hepatic damage in Swiss albino mice.

PubMed

Chaudhuri, Dipankar; Ghate, Nikhil Baban; Panja, Sourav; Mandal, Nripendranath

2016-07-26

Crude Spondias pinnata bark extract was previously assessed for its antioxidant, anticancer and iron chelating potentials. The isolated compounds gallic acid (GA) and methyl gallate (MG) were evaluated for their curative potential against iron overload-induced liver fibrosis and hepatocellular damage. In vitro iron chelation property and in vivo ameliorating potential from iron overload induced liver toxicity of GA and MG was assessed by different biochemical assays and histopathological studies. MG and GA demonstrated excellent reducing power activities but iron chelation potential of MG is better than GA. Oral MG treatment in mice displayed excellent efficacy (better than GA) to significantly restore the levels of liver antioxidants, serum markers and cellular reactive oxygen species in a dose-dependent fashion. Apart from these, MG exceptionally prevented lipid peroxidation and protein oxidation whereas GA demonstrated better activity to reduce collagen content, thereby strengthening its position as an efficient drug against hepatic damage/fibrosis, which was further supported by histopathological studies. Alongside, MG efficiently eliminated the cause of liver damage, i.e., excess iron, by chelating free iron and reducing the ferritin-bound iron. The present study confirmed the curative effect of GA and MG against iron overload hepatic damage via their potent antioxidant and iron-chelating potential.

Effects of electrocautery on transvenous lead insulation materials.

PubMed

Lim, Kiam-Khiang; Reddy, Shantanu; Desai, Shrojal; Smelley, Matthew; Kim, Susan S; Beshai, John F; Lin, Albert C; Burke, Martin C; Knight, Bradley P

2009-04-01

Insulation defects are a leading cause of transvenous lead failure. The purpose of this study was to determine the effects of electrocautery on transvenous lead insulation materials. A preparation was done to simulate dissection of a transvenous lead from tissues. Radiofrequency energy was delivered using a standard cautery blade at outputs of 10, 20, and 30 W, for 3 and 6 seconds, using parallel and perpendicular blade orientations on leads with outermost insulations of silicone rubber, polyurethane, and silicone-polyurethane copolymer. Damage to each lead segment was classified after visual and microscopic analysis. Significant insulation damage occurred to almost all polyurethane leads. Full insulation breaches were observed with 30 W regardless of application duration with a parallel direction and with all power outputs with a perpendicular direction. Thermal insulation damage to copolymer insulation was similar to that of the polyurethane leads. In contrast, there was no thermal damage to silicone leads, regardless of the power output and duration of power delivery. However, mechanical insulation damage was observed to all silicone leads when at least 20 W was applied in a direction perpendicular to the lead. Polyurethane (PU55D) and copolymer materials have low thermal stability and are highly susceptible to thermal damage during cautery. Implanting physicians should be aware of the lead insulation materials being used during implant procedures and their properties. The use of direct contact cautery on transvenous leads should be minimized to avoid damage to the lead, especially on leads with polyurethane or copolymer outer insulations.

Volcano Hazards - A National Threat

USGS Publications Warehouse

,

2006-01-01

When the violent energy of a volcano is unleashed, the results are often catastrophic. The risks to life, property, and infrastructure from volcanoes are escalating as more and more people live, work, play, and travel in volcanic regions. Since 1980, 45 eruptions and 15 cases of notable volcanic unrest have occurred at 33 U.S. volcanoes. Lava flows, debris avalanches, and explosive blasts have invaded communities, swept people to their deaths, choked major riverways, destroyed bridges, and devastated huge tracts of forest. Noxious volcanic gas emissions have caused widespread lung problems. Airborne ash clouds have disrupted the health, lives, and businesses of hundreds of thousands of people; caused millions of dollars of aircraft damage; and nearly brought down passenger flights.

The 7.2 magnitude earthquake, November 1975, Island of Hawaii

USGS Publications Warehouse

1976-01-01

It was centered about 5 km beneath the Kalapana area on the southeastern coast of Hawaii, the largest island of the Hawaiian chain (Fig. 1) and was preceded by numerous foreshocks. The event was accompanied, or followed shortly, by a tsunami, large-scale ground movemtns, hundreds of aftershocks, an eruption in the summit caldera of Kilauea Volcano. The earthquake and the tsunami it generated produced about 4.1 million dollars in property damage, and the tsumani caused two deaths. Although we have some preliminary findings about the cause and effects of the earthquake, detailed scientific investigations will take many more months to complete. This article is condensed from a recent preliminary report (Tillings an others 1976)

Earthquakes in Mississippi and vicinity 1811-2010

USGS Publications Warehouse

Dart, Richard L.; Bograd, Michael B.E.

2011-01-01

This map summarizes two centuries of earthquake activity in Mississippi. Work on the Mississippi map was done in collaboration with the Mississippi Department of Environmental Quality, Office of Geology. The earthquake data plotted on the map are from several sources: the Mississippi Department of Environmental Quality, the Center for Earthquake Research and Information, the National Center for Earthquake Engineering Research, and the Arkansas Geological Survey. In addition to earthquake locations, other materials include seismic hazard and isoseismal maps and related text. Earthquakes are a legitimate concern in Mississippi and parts of adjacent States. Mississippi has undergone a number of felt earthquakes since 1811. At least two of these events caused property damage: a magnitude 4.7 earthquake in 1931, and a magnitude 4.3 earthquake in 1967. The map shows all historical and instrumentally located earthquakes in Mississippi and vicinity between 1811 and 2010. The largest historic earthquake in the vicinity of the State was an intensity XI event, on December 16, 1811; the first earthquake in the New Madrid sequence. This violent event and the earthquakes that followed caused considerable damage to the then sparsely settled region.

Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

PubMed Central

Kwon, Jee Young; Koedrith, Preeyaporn; Seo, Young Rok

2014-01-01

Engineered nanoparticles (NPs) are widely used in many sectors, such as food, medicine, military, and sport, but their unique characteristics may cause deleterious health effects. Close attention is being paid to metal NP genotoxicity; however, NP genotoxic/carcinogenic effects and the underlying mechanisms remain to be elucidated. In this review, we address some metal and metal oxide NPs of interest and current genotoxicity tests in vitro and in vivo. Metal NPs can cause DNA damage such as chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. We also discuss several parameters that may affect genotoxic response, including physicochemical properties, widely used assays/end point tests, and experimental conditions. Although potential biomarkers of nanogenotoxicity or carcinogenicity are suggested, inconsistent findings in the literature render results inconclusive due to a variety of factors. Advantages and limitations related to different methods for investigating genotoxicity are described, and future directions and recommendations for better understanding genotoxic potential are addressed. PMID:25565845

Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate.

PubMed

Cheng, Yung-Hsin; Yang, Shu-Hua; Liu, Chia-Ching; Gefen, Amit; Lin, Feng-Huei

2013-02-15

Reactive oxygen species-induced oxidative stress is involved in apoptosis of nucleus pulposus (NP) cells that can alter cellular phenotype and accelerate disc degeneration. Ferulic acid (FA) possesses an excellent antioxidant and anti-inflammatory properties. In the study, we developed the thermosensitive FA-gelatin/chitosan/glycerol phosphate (FA-G/C/GP) hydrogel which was applied as a sustained release system of FA to treat NP cells from the damage caused by oxidative stress. The gelation temperature of the FA-G/C/GP hydrogel was 32.17 °C. NP cells submitted to oxidative stress promoted by H(2)O(2), and post-treated with FA-G/C/GP exhibited down-regulation of MMP-3 and up-regulation aggrecan and type II collagen in mRNA level. The sulfated-glycosaminoglycan production was increased and the apoptosis was inhibited in the post-treatment group. The results suggest that the thermosensitive FA-G/C/GP hydrogel can treat NP cells from the damage caused by oxidative stress and may apply in minimally invasive surgery for NP regeneration. Copyright © 2012 Elsevier Ltd. All rights reserved.

Do Native Parasitic Plants Cause More Damage to Exotic Invasive Hosts Than Native Non-Invasive Hosts? An Implication for Biocontrol

PubMed Central

Li, Junmin; Jin, Zexin; Song, Wenjing

2012-01-01

Field studies have shown that native, parasitic plants grow vigorously on invasive plants and can cause more damage to invasive plants than native plants. However, no empirical test has been conducted and the mechanism is still unknown. We conducted a completely randomized greenhouse experiment using 3 congeneric pairs of exotic, invasive and native, non-invasive herbaceous plant species to quantify the damage caused by parasitic plants to hosts and its correlation with the hosts' growth rate and resource use efficiency. The biomass of the parasitic plants on exotic, invasive hosts was significantly higher than on congeneric native, non-invasive hosts. Parasites caused more damage to exotic, invasive hosts than to congeneric, native, non-invasive hosts. The damage caused by parasites to hosts was significantly positively correlated with the biomass of parasitic plants. The damage of parasites to hosts was significantly positively correlated with the relative growth rate and the resource use efficiency of its host plants. It may be the mechanism by which parasitic plants grow more vigorously on invasive hosts and cause more damage to exotic, invasive hosts than to native, non-invasive hosts. These results suggest a potential biological control effect of native, parasitic plants on invasive species by reducing the dominance of invasive species in the invaded community. PMID:22493703

A Physical Basis for M s-Yield Scaling in Hard Rock and Implications for Late-Time Damage of the Source Medium

DOE PAGES

Patton, Howard John

2016-04-11

Surface wave magnitude M s for a compilation of 72 nuclear tests detonated in hard rock media for which yields and burial depths have been reported in the literature is shown to scale with yield W as a + b × log[W], where a = 2.50 ± 0.08 and b = 0.80 ± 0.05. While the exponent b is consistent with an M s scaling model for fully coupled, normal containment-depth explosions, the intercept a is offset 0.45 magnitude units lower than the model. The cause of offset is important to understand in terms of the explosion source. Hard rockmore » explosions conducted in extensional and compressional stress regimes show similar offsets, an indication that the tectonic setting in which an explosion occurs plays no role causing the offset. The scaling model accounts for the effects of source medium material properties on the generation of 20-s period Rayleigh wave amplitudes. Aided by thorough characterizations of the explosion and tectonic release sources, an extensive analysis of the 1963 October 26 Shoal nuclear test detonated in granite 27 miles southeast of Fallon NV shows that the offset is consistent with the predictions of a material damage source model related to non-linear stress wave interactions with the free surface. This source emits Rayleigh waves with polarity opposite to waves emitted by the explosion. The Shoal results were extended to analyse surface waves from the 1962 February 15 Hardhat nuclear test, the 1988 September 14 Soviet Joint Verification Experiment, and the anomalous 1979 August 18 northeast Balapan explosion which exhibits opposite polarity, azimuth-independent source component U1 compared to an explosion. Modelling these tests shows that Rayleigh wave amplitudes generated by the damage source are nearly as large as or larger than amplitudes from the explosion. As such, destructive interference can be drastic, introducing metastable conditions due to the sensitivity of reduced amplitudes to Rayleigh wave initial phase angles of the explosion and damage sources. This meta-stability is a likely source of scatter in M s-yield scaling observations. The agreement of observed scaling exponent b with the model suggests that the damage source strength does not vary much with yield, in contrast to explosions conducted in weak media where Ms scaling rates are greater than the model predicts, and the yield dependence of the damage source strength is significant. This difference in scaling behaviour is a consequence of source medium material properties.« less

A Physical Basis for M s-Yield Scaling in Hard Rock and Implications for Late-Time Damage of the Source Medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, Howard John

Surface wave magnitude M s for a compilation of 72 nuclear tests detonated in hard rock media for which yields and burial depths have been reported in the literature is shown to scale with yield W as a + b × log[W], where a = 2.50 ± 0.08 and b = 0.80 ± 0.05. While the exponent b is consistent with an M s scaling model for fully coupled, normal containment-depth explosions, the intercept a is offset 0.45 magnitude units lower than the model. The cause of offset is important to understand in terms of the explosion source. Hard rockmore » explosions conducted in extensional and compressional stress regimes show similar offsets, an indication that the tectonic setting in which an explosion occurs plays no role causing the offset. The scaling model accounts for the effects of source medium material properties on the generation of 20-s period Rayleigh wave amplitudes. Aided by thorough characterizations of the explosion and tectonic release sources, an extensive analysis of the 1963 October 26 Shoal nuclear test detonated in granite 27 miles southeast of Fallon NV shows that the offset is consistent with the predictions of a material damage source model related to non-linear stress wave interactions with the free surface. This source emits Rayleigh waves with polarity opposite to waves emitted by the explosion. The Shoal results were extended to analyse surface waves from the 1962 February 15 Hardhat nuclear test, the 1988 September 14 Soviet Joint Verification Experiment, and the anomalous 1979 August 18 northeast Balapan explosion which exhibits opposite polarity, azimuth-independent source component U1 compared to an explosion. Modelling these tests shows that Rayleigh wave amplitudes generated by the damage source are nearly as large as or larger than amplitudes from the explosion. As such, destructive interference can be drastic, introducing metastable conditions due to the sensitivity of reduced amplitudes to Rayleigh wave initial phase angles of the explosion and damage sources. This meta-stability is a likely source of scatter in M s-yield scaling observations. The agreement of observed scaling exponent b with the model suggests that the damage source strength does not vary much with yield, in contrast to explosions conducted in weak media where Ms scaling rates are greater than the model predicts, and the yield dependence of the damage source strength is significant. This difference in scaling behaviour is a consequence of source medium material properties.« less

Milling of rice grains: effects of starch/flour structures on gelatinization and pasting properties.

PubMed

Hasjim, Jovin; Li, Enpeng; Dhital, Sushil

2013-01-30

Starch gelatinization and flour pasting properties were determined and correlated with four different levels of starch structures in rice flour, i.e. flour particle size, degree of damaged starch granules, whole molecular size, and molecular branching structure. Onset starch-gelatinization temperatures were not significantly different among all flour samples, but peak and conclusion starch-gelatinization temperatures were significantly different and were strongly correlated with the flour particle size, indicating that rice flour with larger particle size has a greater barrier for heat transfer. There were slight differences in the enthalpy of starch gelatinization, which are likely associated with the disruption of crystalline structure in starch granules by the milling processes. Flours with volume-median diameter ≥56 μm did not show a defined peak viscosity in the RVA viscogram, possibly due to the presence of native protein and/or cell-wall structure stabilizing the swollen starch granules against the rupture caused by shear during heating. Furthermore, RVA final viscosity of flour was strongly correlated with the degree of damage to starch granules, suggesting the contribution of granular structure, possibly in swollen form. The results from this study allow the improvement in the manufacture and the selection criteria of rice flour with desirable gelatinization and pasting properties. Copyright © 2012 Elsevier Ltd. All rights reserved.

Wooden beverage cases cause little damage to bottle caps

Treesearch

R. Bruce Anderson; William C. Miller

1973-01-01

Wooden beverage cases cause little damage to aluminum resealable caps during distribution. A study at bottling plants and distribution warehouses showed that an average of 1 bottle out of 4,000 has cap damage. Most of the damage was attributed to handling at the warehouse and in transit. Some recommendations are given for improvement of wooden beverage cases to prevent...

Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension

PubMed Central

Chen, Pin-I; Cao, Aiqin; Miyagawa, Kazuya; Tojais, Nancy F.; Hennigs, Jan K.; Li, Caiyun G.; Sweeney, Nathaly M.; Inglis, Audrey S.; Wang, Lingli; Li, Dan; Ye, Matthew; Feldman, Brian J.

2017-01-01

Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary artery endothelial cells (PAECs) from AMPH-associated-PAH patients show DNA damage as judged by γH2AX foci and DNA comet tails. We therefore hypothesized that AMPH induces DNA damage and vascular pathology by interfering with normal adaptation to an environmental perturbation causing oxidative stress. Consistent with this, we found that AMPH alone does not cause DNA damage in normoxic PAECs, but greatly amplifies DNA damage in hypoxic PAECs. The mechanism involves AMPH activation of protein phosphatase 2A, which potentiates inhibition of Akt. This increases sirtuin 1, causing deacetylation and degradation of HIF1α, thereby impairing its transcriptional activity, resulting in a reduction in pyruvate dehydrogenase kinase 1 and impaired cytochrome c oxidase 4 isoform switch. Mitochondrial oxidative phosphorylation is inappropriately enhanced and, as a result of impaired electron transport and mitochondrial ROS increase, caspase-3 is activated and DNA damage is induced. In mice given binge doses of METH followed by hypoxia, HIF1α is suppressed and pulmonary artery DNA damage foci are associated with worse pulmonary vascular remodeling. Thus, chronic AMPH/METH can induce DNA damage associated with vascular disease by subverting the adaptive responses to oxidative stress. PMID:28138562

Is flood risk capitalized into real estate market values? : a Mahalanobis-metric matching approach to housing market in Busan, South Korea

NASA Astrophysics Data System (ADS)

Jung, E.; Yoon, H.

2016-12-01

Natural disasters are substantial source of social and economic damage around the globe. The amount of damage is larger when such catastrophe events happen in urbanized areas where the wealth is concentrated. Disasters cause losses in real estate assets, incurring additional cost of repair and maintenance of the properties. For this reason, natural hazard risk such as flooding and landslide is regarded as one of the important determinants of homebuyers' choice and preference. In this research, we aim to reveal whether the past records of flood affect real estate market values in Busan, Korea in 2014, under a hypothesis that homebuyers' perception of natural hazard is reflected on housing values, using the Mahalanobis-metric matching method. Unlike conventionally used hedonic pricing model to estimate capitalization of flood risk into the sales price of properties, the analytical method we adopt here enables inferring causal effects by efficiently controlling for observed/unobserved omitted variable bias. This matching approach pairs each inundated property (treatment variable) with a non-inundated property (control variable) with the closest Mahalanobis distance between them, and comparing their effects on residential property sales price (outcome variable). As a result, we expect price discounts for inundated properties larger than the one for comparable non-inundated properties. This research will be valuable in establishing the mitigation policies of future climate change to relieve the possible negative economic consequences from the disaster by estimating how people perceive and respond to natural hazard. This work was supported by the Korea Environmental Industry and Technology Institute (KEITI) under Grant (No. 2014-001-310007).

Assessment of damage in ceramics and ceramic matrix composites using ultrasonic techniques

NASA Technical Reports Server (NTRS)

Chu, Y. C.; Baaklini, G. Y.; Rokhlin, S.I.

1993-01-01

This paper addresses the application of ultrasonic sensing to damage assessment in ceramics and ceramic matrix composites. It focuses on damage caused by thermal shock or oxidation at elevated temperatures, which often results in elastic anisotropy. This damaged-induced anisotropy is determined by measuring the velocities of ultrasonic waves in different propagation directions. Thermal shock damage is assessed in ceramic samples of reaction bonded silicon nitride (RBSN). Thermal shock treatment from different temperatures up to 1000 C is applied to produce the microcracks. Results indicate that most microcracks produced by thermal shock are located near sample surfaces. Ultrasonic measurements using the surface wave method are found to correlate well with measurements of degradation of mechanical properties obtained independently by other authors using destructive methods. Oxidation damage is assessed in silicon carbide fiber/reaction bonded silicon nitride matrix (SCS-6/RBSN) composites. The oxidation is done by exposing the samples in a flowing oxygen environment at elevated temperatures, up to 1400 C, for 100 hr. The Youngs' modulus in the fiber direction as obtained from ultrasonic measurements decreases significantly at 600 C but retains its original value at temperatures above 1200 C. This agrees well with the results of destructive tests by other authors. On the other hand, the transverse moduli obtained from ultrasonic measurements decrease continually until 1200 C. Measurements on the shear stiffnesses show behavior similar to the transverse moduli. The results of this work show that the damage-induced anisotropy in both ceramics and ceramic matrix composites can be determined successfully by ultrasonic methods. This suggests the possibility of assessing damage severity using ultrasonic techniques.

Flood loss assessment in Can Tho City, Vietnam

NASA Astrophysics Data System (ADS)

Do, T. C.; Kreibich, H.

2012-04-01

Floods are recurring events in the Lower Mekong Basin resulting in loss of life and property, causing damage to agriculture and rural infrastructure, and disrupting social and economic activities. Flood management and mitigation has become a priority issue at the national and regional levels. Besides, it is expected that large areas of the Mekong delta, the Red River delta and the central coast will be flooded by sea-level rise due to climate change. Can Tho City is ranked under the five most flood-tide-influenced cities of Vietnam. It is the biggest city in the Mekong delta and it is located near the Hau river. Like other region of the Mekong delta, Can Tho suffers due to floods from upstream and flood tides from the sea. In the flood season large rural areas of the city are flooded, particularly during tidal days. Flood risk management policy includes preparative measures for living with floods and to minimise the damage caused by floods as well as to take advantage of floods for sustainable development. An intensive literature review, including administrative reports as well as expert interviews have been undertaken to gain more insight into flood characteristics, their consequences and risk mitigation. Therefore, flood damaging processes and trends have been reviewed for Can Tho City and the Mekong Basin in Vietnam. Additionally, suitable flood damage estimation methodologies have been collected as important input for flood risk analyses. On this basis it has been investigated which flood risk mitigation and management strategies promise to be effective in Can Tho City, Vietnam.

A Probabilistic Typhoon Risk Model for Vietnam

NASA Astrophysics Data System (ADS)

Haseemkunju, A.; Smith, D. F.; Brolley, J. M.

2017-12-01

Annually, the coastal Provinces of low-lying Mekong River delta region in the southwest to the Red River Delta region in Northern Vietnam is exposed to severe wind and flood risk from landfalling typhoons. On average, about two to three tropical cyclones with a maximum sustained wind speed of >=34 knots make landfall along the Vietnam coast. Recently, Typhoon Wutip (2013) crossed Central Vietnam as a category 2 typhoon causing significant damage to properties. As tropical cyclone risk is expected to increase with increase in exposure and population growth along the coastal Provinces of Vietnam, insurance/reinsurance, and capital markets need a comprehensive probabilistic model to assess typhoon risk in Vietnam. In 2017, CoreLogic has expanded the geographical coverage of its basin-wide Western North Pacific probabilistic typhoon risk model to estimate the economic and insured losses from landfalling and by-passing tropical cyclones in Vietnam. The updated model is based on 71 years (1945-2015) of typhoon best-track data and 10,000 years of a basin-wide simulated stochastic tracks covering eight countries including Vietnam. The model is capable of estimating damage from wind, storm surge and rainfall flooding using vulnerability models, which relate typhoon hazard to building damageability. The hazard and loss models are validated against past historical typhoons affecting Vietnam. Notable typhoons causing significant damage in Vietnam are Lola (1993), Frankie (1996), Xangsane (2006), and Ketsana (2009). The central and northern coastal provinces of Vietnam are more vulnerable to wind and flood hazard, while typhoon risk in the southern provinces are relatively low.

Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons

PubMed Central

Wang, Wei-Ping; Iyo, Abiye H.; Miguel-Hidalgo, Javier; Regunathan, Soundar; Zhu, Meng-Yang

2010-01-01

Agmatine is a polyamine and has been considered as a novel neurotransmitter or neuromodulator in the central nervous system. In the present study, the neuroprotective effect of agmatine against cell damage caused by N-methyl-d-aspartate (NMDA) and glutamate was investigated in cultured rat hippocampal neurons. Lactate dehydrogenase (LDH) activity assay, β-tubulin III immunocytochemical staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick end-labeling (TUNEL) assay were conducted to detect cell damage. Exposure of 12-day neuronal cultures of rat hippocampus to NMDA or glutamate for 1 h caused a concentration-dependent neurotoxicity, as indicated by the significant increase in released LDH activities. Addition of 100 µM agmatine into media ablated the neurotoxicity induced by NMDA or glutamate, an effect also produced by the specific NMDA receptor antagonist dizocilpine hydrogen maleate (MK801). Arcaine, an analog of agmatine with similar structure as agmatine, fully prevented the NMDA- or glutamate-induced neuronal damage. Spermine and putrescine, the endogenous polyamine and metabolic products of agmatine without the guanidine moiety of agmatine, failed to show this effect, indicating a structural relevance for this neuroprotection. Immunocytochemical staining and TUNEL assay confirmed the findings in the LDH measurement. That is, agmatine and MK801 markedly attenuated NMDA-induced neuronal death and significantly reduced TUNEL-positive cell numbers induced by exposure of cultured hippocampal neurons to NMDA. Taken together, these results demonstrate that agmatine can protect cultured hippocampal neurons from NMDA- or glutamate-induced excitotoxicity, through a possible blockade of the NMDA receptor channels or a potential anti-apoptotic property. PMID:16546145

The effects of ozone exposure and associated injury mechanisms on the central nervous system.

PubMed

Martínez-Lazcano, Juan Carlos; González-Guevara, Edith; del Carmen Rubio, María; Franco-Pérez, Javier; Custodio, Verónica; Hernández-Cerón, Miguel; Livera, Carlos; Paz, Carlos

2013-01-01

Ozone (O3) is a component of photochemical smog, which is a major air pollutant and demonstrates properties that are harmful to health because of the toxic properties that are inherent to its powerful oxidizing capabilities. Environmental O3 exposure is associated with many symptoms related to respiratory disorders, which include loss of lung function, exacerbation of asthma, airway damage, and lung inflammation. The effects of O3 are not restricted to the respiratory system or function - adverse effects within the central nervous system (CNS) such as decreased cognitive response, decrease in motor activity, headaches, disturbances in the sleep-wake cycle, neuronal dysfunctions, cell degeneration, and neurochemical alterations have also been described; furthermore, it has also been proposed that O3 could have epigenetic effects. O3 exposure induces the reactive chemical species in the lungs, but the short half-life of these chemical species has led some authors to attribute the injurious mechanisms observed within the lungs to inflammatory processes. However, the damage to the CNS induced by O3 exposure is not well understood. In this review, the basic mechanisms of inflammation and activation of the immune system by O3 exposure are described and the potential mechanisms of damage, which include neuroinflammation and oxidative stress, and the signs and symptoms of disturbances within the CNS caused by environmental O3 exposure are discussed.

Prostate-specific membrane antigen-directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells.

PubMed

Lee, Seung S; Roche, Philip Jr; Giannopoulos, Paresa N; Mitmaker, Elliot J; Tamilia, Michael; Paliouras, Miltiadis; Trifiro, Mark A

2017-03-01

Almost all biological therapeutic interventions cannot overcome neoplastic heterogeneity. Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. Multi-walled carbon nanotubes offer a number of unique properties: chemical stability, photonic properties including efficient light absorption, thermal conductivity, and extensive surface area availability for covalent chemical ligation. When combined together with a targeting moiety such as an antibody or small molecule, one can deliver highly localized temperature increases and cause extensive cellular damage. We have functionalized multi-walled carbon nanotubes by conjugating an antibody against prostate-specific membrane antigen. In our in vitro studies using prostate-specific membrane antigen-positive LNCaP prostate cancer cells, we have effectively demonstrated cell ablation of >80% with a single 30-s exposure to a 2.7-W, 532-nm laser for the first time without bulk heating. We also confirmed the specificity and selectivity of prostate-specific membrane antigen targeting by assessing prostate-specific membrane antigen-null PC3 cell lines under the same conditions (<10% cell ablation). This suggests that we can achieve an extreme nearfield cell ablation effect, thus restricting potential tissue damage when transferred to in vivo clinical applications. Developing this new platform will introduce novel approaches toward current therapeutic modalities and will usher in a new age of effective cancer treatment squarely addressing tumoral heterogeneity.

Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium

PubMed Central

Cooper, Karen L.; Dashner, Erica J.; Tsosie, Ranalda; Cho, Young Mi; Lewis, Johnnye

2015-01-01

Uranium has radiological and non-radiological effects within biological systems and there is increasing evidence for genotoxic and carcinogenic properties attributable to uranium through its heavy metal properties. In this study, we report that low concentrations of uranium (as uranyl acetate; <10 μM) is not cytotoxic to human embryonic kidney cells or normal human keratinocytes; however, uranium exacerbates DNA damage and cytotoxicity induced by hydrogen peroxide, suggesting that uranium may inhibit DNA repair processes. Concentrations of uranyl acetate in the low micromolar range inhibited the zinc finger DNA repair protein poly(ADP-ribose) polymerase (PARP)-1 and caused zinc loss from PARP-1 protein. Uranyl acetate exposure also led to zinc loss from the zinc finger DNA repair proteins Xeroderma Pigmentosum, Complementation Group A (XPA) and aprataxin (APTX). In keeping with the observed inhibition of zinc finger function of DNA repair proteins, exposure to uranyl acetate enhanced retention of induced DNA damage. Co-incubation of uranyl acetate with zinc largely overcame the impact of uranium on PARP-1 activity and DNA damage. These findings present evidence that low concentrations of uranium can inhibit DNA repair through disruption of zinc finger domains of specific target DNA repair proteins. This may provide a mechanistic basis to account for the published observations that uranium exposure is associated with DNA repair deficiency in exposed human populations. PMID:26627003

Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.

PubMed

Cooper, Karen L; Dashner, Erica J; Tsosie, Ranalda; Cho, Young Mi; Lewis, Johnnye; Hudson, Laurie G

2016-01-15

Uranium has radiological and non-radiological effects within biological systems and there is increasing evidence for genotoxic and carcinogenic properties attributable to uranium through its heavy metal properties. In this study, we report that low concentrations of uranium (as uranyl acetate; <10 μM) is not cytotoxic to human embryonic kidney cells or normal human keratinocytes; however, uranium exacerbates DNA damage and cytotoxicity induced by hydrogen peroxide, suggesting that uranium may inhibit DNA repair processes. Concentrations of uranyl acetate in the low micromolar range inhibited the zinc finger DNA repair protein poly(ADP-ribose) polymerase (PARP)-1 and caused zinc loss from PARP-1 protein. Uranyl acetate exposure also led to zinc loss from the zinc finger DNA repair proteins Xeroderma Pigmentosum, Complementation Group A (XPA) and aprataxin (APTX). In keeping with the observed inhibition of zinc finger function of DNA repair proteins, exposure to uranyl acetate enhanced retention of induced DNA damage. Co-incubation of uranyl acetate with zinc largely overcame the impact of uranium on PARP-1 activity and DNA damage. These findings present evidence that low concentrations of uranium can inhibit DNA repair through disruption of zinc finger domains of specific target DNA repair proteins. This may provide a mechanistic basis to account for the published observations that uranium exposure is associated with DNA repair deficiency in exposed human populations. Copyright © 2015 Elsevier Inc. All rights reserved.

20 CFR 10.711 - How is the amount of the recovery of the FECA beneficiary determined?

Code of Federal Regulations, 2014 CFR

2014-04-01

... surviving spouse and children, the recovery is the gross recovery less the portion representing damage to... representing damage to real or personal property, the portion representing loss of consortium, the portion..., the recovery is the gross recovery less the portion representing damage to real or personal property...

20 CFR 10.711 - How is the amount of the recovery of the FECA beneficiary determined?

Code of Federal Regulations, 2013 CFR

2013-04-01

... surviving spouse and children, the recovery is the gross recovery less the portion representing damage to... representing damage to real or personal property, the portion representing loss of consortium, the portion..., the recovery is the gross recovery less the portion representing damage to real or personal property...

20 CFR 10.711 - How is the amount of the recovery of the FECA beneficiary determined?

Code of Federal Regulations, 2012 CFR

2012-04-01

... surviving spouse and children, the recovery is the gross recovery less the portion representing damage to... representing damage to real or personal property, the portion representing loss of consortium, the portion..., the recovery is the gross recovery less the portion representing damage to real or personal property...

41 CFR 109-1.5113 - Loss, damage, or destruction of personal property in possession of designated contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... designated contractors. (a) Designated contractors shall report any loss, damage, or destruction of personal... administrator; or loss, damage, or destruction of personal property not previously reported by the contractor... written reports. (c) Reports of physical inventory results and identified discrepancies shall be submitted...

41 CFR 109-1.5113 - Loss, damage, or destruction of personal property in possession of designated contractors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... designated contractors. (a) Designated contractors shall report any loss, damage, or destruction of personal... administrator; or loss, damage, or destruction of personal property not previously reported by the contractor... written reports. (c) Reports of physical inventory results and identified discrepancies shall be submitted...

Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems

NASA Astrophysics Data System (ADS)

Caon, Thiago; Zanetti-Ramos, Betina Giehl; Lemos-Senna, Elenara; Cloutet, Eric; Cramail, Henri; Borsali, Redouane; Soldi, Valdir; Simões, Cláudia Maria Oliveira

2010-06-01

The in vitro cytotoxicity and DNA damage evaluation of biodegradable polyurethane-based micro- and nanoparticles were carried out on animal fibroblasts. For cytotoxicity measurement and primary DNA damage evaluation, MTT and Comet assays were used, respectively. Different formulations were tested to evaluate the influence of chemical composition and physicochemical characteristics of particles on cell toxicity. No inhibition of cells growth surrounding the polyurethane particles was observed. On the other hand, a decrease of cell viability was verified when the anionic surfactant sodium dodecyl sulfate (SDS) was used as droplets stabilizer of monomeric phase. Polyurethane nanoparticles stabilized with Tween 80 and Pluronic F68 caused minor cytotoxic effects. These results indicated that the surface charge plays an important role on cytotoxicity. Particles synthesized from MDI displayed a higher cytotoxicity than those synthesized from IPDI. Size and physicochemical properties of the particles may explain the higher degree of DNA damage produced by two tested formulations. In this way, a rational choice of particles' constituents based on their cytotoxicity and genotoxicity could be very useful for conceiving biomaterials to be used as drug delivering systems.

Runoff inundation hazard cartography

NASA Astrophysics Data System (ADS)

Pineux, N.; Degré, A.

2012-04-01

Between 1998 and 2004, Europe suffered from more than hundred major inundations, responsible for some 700 deaths, for the moving of about half a million of people and the economic losses of at least 25 billions Euros covered by the insurance policies. Within this context, EU launched the 2007/60/CE directive. The inundations are natural phenomenon. They cannot be avoided. Nevertheless this directive permits to better evaluate the risks and to coordinate the management measures taken at member states level. In most countries, inundation maps only include rivers' overflowing. In Wallonia, overland flows and mudflows also cause huge damages, and must be included in the flood hazard map. Indeed, the cleaning operations for a village can lead to an estimated cost of 11 000 €. Average construction cost of retention dams to control off-site damage caused by floods and muddy flows was valued at 380 000€, and yearly dredging costs associated with these retention ponds at 15 000€. For a small city for which a study was done in a more specific way (Gembloux), the mean annual cost for the damages that can generate the runoff is about 20 000€. This cost consists of the physical damages caused to the real estate and movable properties of the residents as well as the emergency operations of the firemen and the city. On top of damages to public infrastructure (clogging of trenches, silting up of retention ponds) and to private property by muddy flows, runoff generates a significant loss of arable land. Yet, the soil resource is not an unlimited commodity. Moreover, sediments' transfer to watercourses alters their physical and chemical quality. And that is not to mention the increased psychological stress for people. But to map overland flood and mud flow hazard is a real challenge. This poster will present the methodology used to in Wallonia. The methodology is based on 3 project rainfalls: 25, 50 and 100 years return period (consistency with the cartography of the overflowing hazard map), with a rain duration set at 1h. The arable lands are considered as bare, except for the permanent meadows. The worst situation is envisaged, the hydrologic effect of the soil cover in the farming area being variable from a year to another according to the vegetative development and to the cultural operations. The peak discharge is chosen as the more critic parameter because it synthesizes the watershed propensity to stream, its size, and its flow network. The cartographic representation is done in a linear way along the concentrated runoff axes. Whereas this first approach at regional scale includes uncertainties, the aim of this map is currently to prompt consideration of the runoff inundation hazard during the design of urban development projects.

Lower Length Scale Model Development for Embrittlement of Reactor Presure Vessel Steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yongfeng; Schwen, Daniel; Chakraborty, Pritam

2016-09-01

This report summarizes the lower-length-scale effort during FY 2016 in developing mesoscale capabilities for microstructure evolution, plasticity and fracture in reactor pressure vessel steels. During operation, reactor pressure vessels are subject to hardening and embrittlement caused by irradiation induced defect accumulation and irradiation enhanced solute precipitation. Both defect production and solute precipitation start from the atomic scale, and manifest their eventual effects as degradation in engineering scale properties. To predict the property degradation, multiscale modeling and simulation are needed to deal with the microstructure evolution, and to link the microstructure feature to material properties. In this report, the development ofmore » mesoscale capabilities for defect accumulation and solute precipitation are summarized. A crystal plasticity model to capture defect-dislocation interaction and a damage model for cleavage micro-crack propagation is also provided.« less

Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor.

PubMed

Zhou, Dan; Cheng, Hongjing; Liu, Jinyu; Zhang, Lei

2017-06-01

Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, we verified the property of transfected cells through detecting surface marker by flow cytometry. We show here establishment of the hHGF-overexpressing lentivirus vector, and successfully transfection to human hair follicle mesenchymal stem cells. The verified experiments could demonstrate the human hair follicle mesenchymal stem cells which have been transfected still have the properties of stem cells. We successfully constructed human hair follicle mesenchymal stem cells which overexpression hHGF, and maintain the same properties compared with pro-transfected cells.

3D Progressive Damage Modeling for Laminated Composite Based on Crack Band Theory and Continuum Damage Mechanics

NASA Technical Reports Server (NTRS)

Wang, John T.; Pineda, Evan J.; Ranatunga, Vipul; Smeltzer, Stanley S.

2015-01-01

A simple continuum damage mechanics (CDM) based 3D progressive damage analysis (PDA) tool for laminated composites was developed and implemented as a user defined material subroutine to link with a commercially available explicit finite element code. This PDA tool uses linear lamina properties from standard tests, predicts damage initiation with an easy-to-implement Hashin-Rotem failure criteria, and in the damage evolution phase, evaluates the degradation of material properties based on the crack band theory and traction-separation cohesive laws. It follows Matzenmiller et al.'s formulation to incorporate the degrading material properties into the damaged stiffness matrix. Since nonlinear shear and matrix stress-strain relations are not implemented, correction factors are used for slowing the reduction of the damaged shear stiffness terms to reflect the effect of these nonlinearities on the laminate strength predictions. This CDM based PDA tool is implemented as a user defined material (VUMAT) to link with the Abaqus/Explicit code. Strength predictions obtained, using this VUMAT, are correlated with test data for a set of notched specimens under tension and compression loads.

Repair-Resistant DNA Lesions

PubMed Central

2017-01-01

The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is growing evidence that certain DNA lesions are repaired slowly or are entirely resistant to repair in cells, tissues, and in cell extract model assay systems. It is well established that the eukaryotic DNA lesion-sensing proteins do not detect the damaged nucleotide, but recognize the distortions/destabilizations in the native DNA structure caused by the damaged nucleotides. In this article, the nature of the structural features of certain bulky DNA lesions that render them resistant to NER, or cause them to be repaired slowly, is compared to that of those that are good-to-excellent NER substrates. Understanding the structural features that distinguish NER-resistant DNA lesions from good NER substrates may be useful for interpreting the biological significance of biomarkers of exposure of human populations to genotoxic environmental chemicals. NER-resistant lesions can survive to replication and cause mutations that can initiate cancer and other diseases. Furthermore, NER diminishes the efficacy of certain chemotherapeutic drugs, and the design of more potent pharmaceuticals that resist repair can be advanced through a better understanding of the structural properties of DNA lesions that engender repair-resistance. PMID:28750166

Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney.

PubMed

Cano-Europa, Edgar; Blas-Valdivia, Vanessa; Franco-Colin, Margarita; Gallardo-Casas, Carlos Angel; Ortiz-Butrón, Rocio

2011-01-01

It is known that a hypothyroidism-induced hypometabolic state protects against oxidative damage caused by toxins. However, some workers demonstrated that antithyroid drug-induced hypothyroidism can cause cellular damage. Our objective was to determine if methimazole (an antithyroid drug) or hypothyroidism causes cellular damage in the liver, kidney, lung, spleen and heart. Twenty-five male Wistar rats were divided into 5 groups: euthyroid, false thyroidectomy, thyroidectomy-induced hypothyroidism, methimazole-induced hypothyroidism (60 mg/kg), and treatment with methimazole (60 mg/kg) and a T₄ injection (20 μg/kg/d sc). At the end of the treatments (4 weeks for the pharmacological groups and 8 weeks for the surgical groups), the animals were anesthetized with sodium pentobarbital and they were transcardially perfused with 10% formaldehyde. The spleen, heart, liver, lung and kidney were removed and were processed for embedding in paraffin wax. Coronal sections were stained with hematoxylin-eosin. At the end of treatment, animals with both the methimazole- and thyroidectomy-induced hypothyroidism had a significant reduction of serum concentration of thyroid hormones. Only methimazole-induced hypothyroidism causes cellular damage in the kidney, lung, liver, heart, kidney and spleen. In addition, animals treated with methimazole and T₄ showed cellular damage in the lung, spleen and renal medulla with lesser damage in the liver, renal cortex and heart. The thyroidectomy only altered the lung structure. The alterations were prevented by T₄ completely in the heart and partially in the kidney cortex. These results indicate that tissue damage found in hypothyroidism is caused by methimazole. Copyright © 2009 Elsevier GmbH. All rights reserved.

Human impacts of hydrometeorological extremes in the Bohemian-Moravian Highlands derived from documentary sources in the 18th-19th centuries

NASA Astrophysics Data System (ADS)

Dolák, Lukáš; Brázdil, Rudolf; Valášek, Hubert

2014-05-01

The extent of damage caused by hydrometeorological events or extremes (HME) has risen up in the entire world in the last few years. Especially the floods, flash floods, torrential rains and hailstorms are the most typical and one of the most frequent kind of natural disasters in the central Europe. Catastrophes are a part of human history and people were forced to cope with their consequences (e. g. material damage, economical losses, impacts on agriculture and society or losses of human lives). This paper analyses the human impacts of HME in the Bohemian-Moravian Highlands (central part of the Czech Republic) on the basis of documentary sources from the 18th-19th centuries. The paper presents various negative impacts of natural disasters on lives and property and subsequent inconveniences of Czech peasants. The preserved archival documents of estates or domains became the primary sources of data (e. g. taxation reliefs, damaged records, reports of afflicted farmers, administrative correspondence etc.). Particularly taxation reliefs relate to taxation system in the Czech lands during the 17th-19th centuries allowing to farmers to ask for tax alleviation when their crops were significantly damaged by any HME. These archival documents are a highly valuable source for the study of human impacts of natural disasters. Devastating consequences of these extremes affected individual farmers much more than the aristocracy. Floods caused inundations of farmer's fields, meadows, houses and farm buildings, washed away the arable land with crops, caused losses of cattle, clogged the land with gravel and mud and destroyed roads, bridges or agricultural equipment. Afflicted fields became worthless and it took them many years to become became fertile again. Crop was also damaged by hailstorms, droughts or late/early frosts. All these events led to lack of food and seeds in the following year and it meant the decrease of living standard, misery and poverty of farmers. Acquired results could give better insight of human impacts of HME in history and help to compare the negative consequences in the past and present.

Gas exchange recovery following natural drought is rapid unless limited by loss of leaf hydraulic conductance: evidence from an evergreen woodland.

PubMed

Skelton, Robert P; Brodribb, Timothy J; McAdam, Scott A M; Mitchell, Patrick J

2017-09-01

Drought can cause major damage to plant communities, but species damage thresholds and postdrought recovery of forest productivity are not yet predictable. We used an El Niño drought event as a natural experiment to test whether postdrought recovery of gas exchange could be predicted by properties of the water transport system, or if metabolism, primarily high abscisic acid concentration, might delay recovery. We monitored detailed physiological responses, including shoot sapflow, leaf gas exchange, leaf water potential and foliar abscisic acid (ABA), during drought and through the subsequent rehydration period for a sample of eight canopy and understory species. Severe drought caused major declines in leaf water potential, elevated foliar ABA concentrations and reduced stomatal conductance and assimilation rates in our eight sample species. Leaf water potential surpassed levels associated with incipient loss of leaf hydraulic conductance in four species. Following heavy rainfall gas exchange in all species, except those trees predicted to have suffered hydraulic impairment, recovered to prestressed rates within 1 d. Recovery of plant gas exchange was rapid and could be predicted by the hydraulic safety margin, providing strong support for leaf vulnerability to water deficit as an index of damage under natural drought conditions. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells.

PubMed

Hegde, Mahesh; Vartak, Supriya V; Kavitha, Chandagirikoppal V; Ananda, Hanumappa; Prasanna, Doddakunche S; Gopalakrishnan, Vidya; Choudhary, Bibha; Rangappa, Kanchugarakoppal S; Raghavan, Sathees C

2017-05-31

Chemically synthesized small molecules play important role in anticancer therapy. Several chemical compounds have been reported to damage the DNA, either directly or indirectly slowing down the cancer cell progression by causing a cell cycle arrest. Direct or indirect reactive oxygen species formation causes DNA damage leading to cell cycle arrest and subsequent cell death. Therefore, identification of chemically synthesized compounds with anticancer potential is important. Here we investigate the effect of benzothiazole derivative (5g) for its ability to inhibit cell proliferation in different cancer models. Interestingly, 5g interfered with cell proliferation in both, cell lines and tumor cells leading to significant G2/M arrest. 5g treatment resulted in elevated levels of ROS and subsequently, DNA double-strand breaks (DSBs) explaining observed G2/M arrest. Consistently, we observed deregulation of many cell cycle associated proteins such as CDK1, BCL2 and their phosphorylated form, CyclinB1, CDC25c etc. Besides, 5g treatment led to decreased levels of mitochondrial membrane potential and activation of apoptosis. Interestingly, 5g administration inhibited tumor growth in mice without significant side effects. Thus, our study identifies 5g as a potent biochemical inhibitor to induce G2/M phase arrest of the cell cycle, and demonstrates its anticancer properties both ex vivo and in vivo.

Induced seismicity and the potential for liability under U.S. law

NASA Astrophysics Data System (ADS)

Cypser, Darlene A.; Davis, Scott D.

1998-04-01

Research by seismologists over the past 30+ years has firmly established that some human activities induce seismicity. Sometimes induced seismicity causes injuries to people or property. The activities which induce seismicity generally involve extraction of energy, or natural resources, or the disposal of wastes. As the human population increases these extraction and disposal activities will increase in number of sites and intensity of effort as the demands become greater and the resources scarcer. With these increases the number and severity of damaging induced earthquakes is likely to increase. Induced seismicity may cause injuries by vibrations or by seismically induced ground failure. In either case compensation for injuries caused by induced seismicity should be paid for by the inducer. In the United States the inducer of damaging seismicity can be made to pay for the harm caused. Liability for damage caused by vibrations can be based on several legal theories: trespass, strict liability, negligence and nuisance. Our research revealed no cases in which an appellate court has upheld or rejected the application of tort liability to an induced earthquake situation. However, there are numerous analogous cases that support the application of these legal theories to induced seismicity. Vibrations or concussions due to blasting or heavy machinery are sometimes viewed as a `trespass' analogous to a physical invasion. In some states activities which induce earthquakes might be considered `abnormally dangerous' activities that require companies engaged in them to pay for injuries the quakes cause regardless of how careful the inducers were. In some circumstances, a court may find that an inducer was negligent in its site selection or in maintenance of the project. If induced seismicity interferes with the use or enjoyment of another's land, then the inducing activity may be a legal nuisance, even if the seismicity causes little physical damage. In most states of the United States owners of land owe a duty of lateral support to adjacent landowners, and, in some states, mineral estate owners and lessees owe a duty of subjacent support to the surface owners. Failure to meet those duties of support can result in liability. Seismicity induced by one source might accelerate failure of support originating from another source, leaving both of the parties at fault proportionally liable to the injured parties. Geoscientists can use their roles as investigators, educators and advisors to help companies in the petroleum, mining and geothermal fields avoid liability.

Damage from wind and other causes in mixed white fir-red fir stands adjacent to clearcuttings

Treesearch

Donald T. Gordon

1973-01-01

Damage to timber surrounding clearcuttings and in one light selection cutting in mixed white fir-red fir stands was monitored for 6 years in northeastern California. In some years, bark beetles apparently killed more trees than did wind damage, but in two of the study years, severe wind storms caused much damage. One storm produced mainly break-age, apparently...

Foam on Tile Impact Modeling for the STS-107 Investigation

NASA Technical Reports Server (NTRS)

Stellingwerf, R. F.; Robinson, J. H.; Richardson, S.; Evans, S. W.; Stallworth, R.; Hovater, M.

2004-01-01

Following the breakup of the Space Shuttle Columbia during reentry a NASA/Contractor investigation team was formed to examine the probable damage inflicted on Orbiter Thermal Protection System elements by impact of External Tank insulating foam projectiles. The authors formed a working subgroup within the larger team to apply the Smooth Particle Hydrodynamics code SPHC to the damage estimation problem. Numerical models of the Orbiter's tiles and of the Tank's foam were constructed and used as inputs into the code. Material properties needed to properly model the tiles and foam were obtained from other working subgroups who performed tests on these items for this purpose. Two- and three-dimensional models of the tiles were constructed, including the glass outer layer, the main body of LI-900 insulation, the densified lower layer of LI-900, the Nomex felt mounting layer, and the Aluminum 2024 vehicle skin. A model for the BX-250 foam including porous compression, elastic rebound, and surface erosion was developed. Code results for the tile damage and foam behavior were extensively validated through comparison with Southwest Research Institute foam-on-tile impact experiments carried out in 1999. These tests involved small projectiles striking individual tiles and small tile arrays. Following code and model validation we simulated impacts of larger foam projectiles on the examples of tile systems used on the Orbiter. Results for impacts on the main landing gear door are presented in this paper, including effects of impacts at several angles, and of rapidly rotating projectiles. General results suggest that foam impacts on tiles at about 500 mph could cause appreciable damage if the impact angle is greater than about 20 degrees. Some variations of the foam properties, such as increased brittleness or increased density could increase damage in some cases. Rotation up to 17 rps failed to increase the damage for the two cases considered. This does not rule out other cases in which the rotational energy might lead to an increase in tile damage, but suggests that in most cases rotation will not be an important factor.

24 CFR 203.378 - Property condition.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the Commissioner, the property shall be undamaged by fire, earthquake, flood, or tornado, except as... mortgagee shall be responsible for: (1) Damage by fire, flood, earthquake, hurricane, or tornado; (2) Damage...

24 CFR 203.378 - Property condition.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the Commissioner, the property shall be undamaged by fire, earthquake, flood, or tornado, except as... mortgagee shall be responsible for: (1) Damage by fire, flood, earthquake, hurricane, or tornado; (2) Damage...

24 CFR 203.378 - Property condition.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the Commissioner, the property shall be undamaged by fire, earthquake, flood, or tornado, except as... mortgagee shall be responsible for: (1) Damage by fire, flood, earthquake, hurricane, or tornado; (2) Damage...

24 CFR 203.378 - Property condition.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the Commissioner, the property shall be undamaged by fire, earthquake, flood, or tornado, except as... mortgagee shall be responsible for: (1) Damage by fire, flood, earthquake, hurricane, or tornado; (2) Damage...

24 CFR 203.378 - Property condition.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the Commissioner, the property shall be undamaged by fire, earthquake, flood, or tornado, except as... mortgagee shall be responsible for: (1) Damage by fire, flood, earthquake, hurricane, or tornado; (2) Damage...

Effects of substrate on the femtosecond laser-induced damage properties of gold films

NASA Astrophysics Data System (ADS)

Huang, Haopeng; Wang, Leilei; Kong, Fanyu; Xia, Zhilin; Jin, Yunxia; Xu, Jiao; Chen, Junming; Cui, Yun; Shao, Jianda

2018-07-01

In this work, gold films on two different types of substrates were fabricated by electron beam (e-beam) evaporation, and the femtosecond laser-induced damage properties were evaluated. The first sample was gold film deposited on fused silica, whereas the second was gold deposited on photoresist. 1-on-1 damage tests were implemented by an 800 ± 30 nm laser with pulse duration of 30 fs. Different damage thresholds and morphologies were obtained for the two samples. The damage threshold of the gold film on fused silica was 0.64 J/cm2, with the typical damage morphology of thermal ablation and melting; the damage threshold of the gold film on photoresist was 0.30 J/cm2, with the typical damage morphology of blisters or peeling off. In order to better understand the impact of the substrate on the properties of the whole sample, the normalized electric field intensity, temperature, and thermal stress distributions were calculated. The adhesion between the gold film and substrate were measured and the experimental results well agreed with the theoretical analysis. The results indicate that gold films deposited onto grating-structured fused silica will have more powerful laser damage resistance performance.

Landsliding and flooding event triggered by heavy rains in the Rize region

NASA Astrophysics Data System (ADS)

Yalcin, Ali; Kavurmaci, M. Murat

2013-04-01

Rize province has been significantly damaged by frequent landslides and floods which are caused by severe rainfalls and result in many casualties. The area is prone to landslides because of the climate conditions, geologic, and land cover characteristics of the region. The most recent landslide occurred on August 26, 2010 in Gundogdu town. The landslides have caused large numbers of casualties and huge economic losses in the region. Thirteen people died, twenty houses collapsed, more than a hundred houses damaged, and one hundred fifty vehicles were damaged in the Gundogdu landslide. Flood event is often seen in the region of Rize, due to continuous rainfall. Floods cause huge loss of life and property in this region. Rainfall is the most frequent landslide-triggering factor in East Black Sea region, Turkey, especially Rize region. Rize is the rainiest city of Turkey. Total annual precipitation is over 2300 mm, and precipitation is equally distributed in each month. However, in August 26, 166.5 mm precipitation rained within 24 hours in the region and this rainstorm caused great damage. The intensity rainfall periods were become as an indicator of landslide activity. It is very important that the presence of suitable lithologic units for occurring landslides. There are appropriate materials to contributed constitution of landslides in the study area; completely weathered dacite. In addition, intensity land cover types as tea plantations have been blocked surface flows and rainfall is able to quickly penetrate into the soil through open tension cracks that appear in the landslide head and in stretching zones. According to the results of the analysis, the study area has been overlaid tea garden 70 % percentage approximately. Furthermore, the landslide risks have increased by devastation of land cover in this region. In this region, over-steepened slopes, slope saturation in areas of heavy rainfall, and removal of slope vegetation can also increase landslide potential. The combination of all these effects have been affected to the settlement areas and living people in the study area. In this study, the effects of all the factors were separately examined on landslides.

Terrain changes, caused by the 15-17 June 2013 heavy rainfall in the Garhwal Himalaya, India: A case study of Alaknanda and Mandakini basins

NASA Astrophysics Data System (ADS)

Mehta, Manish; Shukla, Tanuj; Bhambri, Rakesh; Gupta, Anil K.; Dobhal, D. P.

2017-05-01

Exceptional early high monsoon rains between 15 and 17 June 2013 combined with discharge from snowmelt water caused widespread floods in every major river of the Garhwal Himalaya. This catastrophic event triggered widespread landslides and devastation in the region, affecting the movement of the people that led to stranding of pilgrims in various pilgrimage routes. This event caused many casualties and irreparable damage to the infrastructures and property in the Garhwal Himalaya. A large volume of debris was deposited in Kedarnath town (3.9 × 106 m3), and a huge amount of debris was removed from Rambara and surrounding areas (2.6 × 108 m3). The study also found that villages like Lambaghar, Bhyundar (Alaknanda River Valley), and Rambara (Mandakini River Valley) were completely washed away, leaving no trace of earlier settlement. Govindghat and Pulna villages in the Alaknanda River Valley were also badly damaged. Approximately 0.3 × 106 and 0.72 × 106 m3 of debris was deposited, respectively. Similarly in the Mandakini Valley, Kedarnath and Sonprayag towns were also badly damaged and 3.9 × 106 and 1.4 × 106 m3 of debris was deposited in the area, respectively. Simultaneously, the moraine-dammed Chorabari Lake breached releasing 6.1 × 105 m3 of water with an average rate of 1429 m3/s (discharge of lake). The towns of Pandukeshwar in the Alaknanda Valley and Gaurikund in the Mandakini Valley were partially damaged. However, no evidence of such magnitude of destruction was reported from the Yamuna River Valley during the same period. This catastrophic event changed the landscape in many parts of Uttarakhand, making the whole region more fragile and vulnerable. A disaster of such magnitude was perhaps not witnessed by the region for at least the last 100 years.

Damage assessment of RC buildings subjected to the different strong motion duration

NASA Astrophysics Data System (ADS)

Mortezaei, Alireza; mohajer Tabrizi, Mohsen

2015-07-01

An earthquake has three important characteristics; namely, amplitude, frequency content and duration. Amplitude and frequency content have a direct impact but not necessarily the sole cause of structural damage. Regarding the duration, some researchers show a high correlation between strong motion duration and structural damage whereas some others find no relation. This paper focuses on the ground motion durations characterized by Arias Intensity (AI). High duration may increase the damage state of structure for the damage accumulation. This paper investigates the response time histories (acceleration, velocity and displacement) of RC buildings under the different strong motion durations. Generally, eight earthquake records were selected from different soil type, and these records were grouped according to their PGA and frequency ranges. Maximum plastic rotation and drift response was chosen as damage indicator. In general, there was a positive correlation between strong motion duration and damage; however, in some PGA and frequency ranges input motions with shorter durations might cause more damage than the input motions with longer durations. In soft soils, input motions with longer durations caused more damage than the input motions with shorter durations.

The Integral Theory System Questionnaire: an anatomically directed questionnaire to determine pelvic floor dysfunctions in women.

PubMed

Wagenlehner, Florian Martin Erich; Fröhlich, Oliver; Bschleipfer, Thomas; Weidner, Wolfgang; Perletti, Gianpaolo

2014-06-01

Anatomical damage to pelvic floor structures may cause multiple symptoms. The Integral Theory System Questionnaire (ITSQ) is a holistic questionnaire that uses symptoms to help locate damage in specific connective tissue structures as a guide to reconstructive surgery. It is based on the integral theory, which states that pelvic floor symptoms and prolapse are both caused by lax suspensory ligaments. The aim of the present study was to psychometrically validate the ITSQ. Established psychometric properties including validity, reliability, and responsiveness were considered for evaluation. Criterion validity was assessed in a cohort of 110 women with pelvic floor dysfunctions by analyzing the correlation of questionnaire responses with objective clinical data. Test-retest was performed with questionnaires from 47 patients. Cronbach's alpha and "split-half" reliability coefficients were calculated for inner consistency analysis. Psychometric properties of ITSQ were comparable to the ones of previously validated Pelvic Floor Questionnaires. Face validity and content validity were approved by an expert group of the International Collaboration of Pelvic Floor surgeons. Convergent validity assessed using Bayesian method was at least as accurate as the expert assessment of anatomical defects. Objective data measurement in patients demonstrated significant correlations with ITSQ domains fulfilling criterion validity. Internal consistency values ranked from 0.85 to 0.89 in different scenarios. The ITSQ proofed accurate and is able to serve as a holistic Pelvic Floor Questionnaire directing symptoms to site-specific pelvic floor reconstructive surgery.

1980 Weather summary

NASA Astrophysics Data System (ADS)

Bell, Peter M.

The weather in the United States during 1980 was bad. A 3-month heat wave in the southwest caused about $20 billion in ruined crops, an increase in power consumption, and damage to roads and highways. Nationwide, the heat killed 1320 people. Floods caused more than $1 billion in losses. Hurricane Allen caused about $500 million in property losses and took two lives.The highest temperature reading during 1980, 51°C (124°F), was reached five times. Locations were at Bull Head, Arizona; Death Valley, California; and three times at Baker, California. Preliminary figures also show that the lowest temperature for the year was recorded at Tok weather station, 150 miles southeast of Fairbanks, Alaska. There the mercury plummeted to -56°C (-68°F). In the lower 48 states the minimum thermometer reading was -44°C at Wisdom, Montana.

Tornado disaster--Kansas, 1991.

PubMed

1992-03-13

On April 26, 1991, 54 tornadoes swept across six midwestern states, causing 24 deaths and more than 200 injuries, requiring disaster-relief services for more than 8000 persons, and causing property damage of more than $250 million. In Kansas, one tornado, with wind speeds exceeding 260 mph, caused 17 deaths. The 46-mile path of the tornado led through Andover, Kansas (Butler County) (population: 4300), where the town's only outdoor warning siren failed. A mobile-home park (MHP) in Andover with 244 homes and one community storm shelter was struck by the tornado, resulting in the destruction of 205 (84%) of these homes. This report summarizes a poststorm survey, conducted by local health departments, the Kansas Department of Health and Environment, the American Red Cross, and CDC, to identify risk factors for injury and death among persons in the MHP.

Nanogravimetric and voltammetric DNA-hybridization biosensors for studies of DNA damage by common toxicants and pollutants.

PubMed

Nowicka, Anna M; Kowalczyk, Agata; Stojek, Zbigniew; Hepel, Maria

2010-01-01

Electrochemical and nanogravimetric DNA-hybridization biosensors have been developed for sensing single mismatches in the probe-target ssDNA sequences. The voltammetric transduction was achieved by coupling ferrocene moiety to streptavidin linked to biotinylated tDNA. The mass-related frequency transduction was implemented by immobilizing the sensory pDNA on a gold-coated quartz crystal piezoresonators oscillating in the 10MHz band. The high sensitivity of these sensors enabled us to study DNA damage caused by representative toxicants and environmental pollutants, including Cr(VI) species, common pesticides and herbicides. We have found that the sensor responds rapidly to any damage caused by Cr(VI) species, with more severe DNA damage observed for Cr(2)O(7)(2-) and for CrO(4)(2-) in the presence of H(2)O(2) as compared to CrO(4)(2-) alone. All herbicides and pesticides examined caused DNA damage or structural alterations leading to the double-helix unwinding. Among these compounds, paraoxon-ethyl and atrazine caused the fastest and most severe damage to DNA. The physico-chemical mechanism of damaging interactions between toxicants and DNA has been proposed. The methodology of testing voltammetric and nanogravimetric DNA-hybridization biosensors developed in this work can be employed as a simple protocol to obtain rapid comparative data concerning DNA damage caused by herbicide, pesticides and other toxic pollutants. The DNA-hybridization biosensor can, therefore, be utilized as a rapid screening device for classifying environmental pollutants and to evaluate DNA damage induced by these compounds.

Empirical Models for Quantification of Machining Damage in Composite Materials

NASA Astrophysics Data System (ADS)

Machado, Carla Maria Moreira

The tremendous growth which occurs at a global level of demand and use of composite materials brings with the need to develop new manufacturing tools and methodologies. One of the major uses of such materials, in particular plastics reinforced with carbon fibres, is their application in structural components for the aircraft industry with low weight and high stiffness. These components are produced in near-final form but the so-called secondary processes such as machining are often unavoidable. In this type of industry, drilling is the most frequent operation due to the need to obtain holes for riveting and fastening bolt assembly of structures. However, the problems arising from drilling, particularly the damage caused during the operation, may lead to rejection of components because it is an origin of lack of resistance. The delamination is the most important damage, as it causes a decrease of the mechanical properties of the components of an assembly and, irrefutably, a reduction of its reliability in use. It can also raise problems with regard to the tolerances of the assemblies. Moreover, the high speed machining is increasingly recognized to be a manufacturing technology that promotes productivity by reducing production times. However, the investigation whose focus is in high speed drilling is quite limited, and few studies on this subject have been found in the literature review. Thus, this thesis aims to investigate the effects of process variables in high speed drilling on the damage produced. The empirical models that relate the delamination damage, the thrust force and the torque with the process parameters were established using Response Surface Methodology. The process parameters considered as input factors were the spindle speed, the feed per tooth, the tool diameter and the workpiece thickness. A new method for fixing the workpiece was developed and tested. The results proved to be very promising since in the same cutting conditions and with this new methodology, it was observed a significant reduction of the delamination damage. Finally, it has been found that is possible to use high speed drilling, using conventional twist drills, to produce holes with good quality, minimizing the damage.

10 CFR 140.94 - Appendix D-Form of indemnity agreement with Federal agencies.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., disease, or death, or loss of or damage to property, or loss of use of property, arising out of or... bodily injury, sickness, disease, or death, or loss of or damage to property, or loss of use of property... harmless the licensee and other persons indemnified, as their interest may appear, from public liability. 2...

10 CFR 140.94 - Appendix D-Form of indemnity agreement with Federal agencies.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., disease, or death, or loss of or damage to property, or loss of use of property, arising out of or... bodily injury, sickness, disease, or death, or loss of or damage to property, or loss of use of property... harmless the licensee and other persons indemnified, as their interest may appear, from public liability. 2...

10 CFR 140.94 - Appendix D-Form of indemnity agreement with Federal agencies.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., disease, or death, or loss of or damage to property, or loss of use of property, arising out of or... bodily injury, sickness, disease, or death, or loss of or damage to property, or loss of use of property... harmless the licensee and other persons indemnified, as their interest may appear, from public liability. 2...

10 CFR 140.94 - Appendix D-Form of indemnity agreement with Federal agencies.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., disease, or death, or loss of or damage to property, or loss of use of property, arising out of or... bodily injury, sickness, disease, or death, or loss of or damage to property, or loss of use of property... harmless the licensee and other persons indemnified, as their interest may appear, from public liability. 2...

32 CFR 537.16 - Scope for maritime claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... claims for damage to: (1) DA-accountable properties of a kind that are within the federal maritime jurisdiction. (2) Property under the DA's jurisdiction or DA property damaged by a vessel or floating object... services (including contract salvage and towage) performed by the DA. Claims for salvage services are based...

Nucleotide excision repair deficient mouse models and neurological disease

PubMed Central

Niedernhofer, Laura J.

2008-01-01

Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA base damage. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy are three human diseases caused by inherited defects in NER. The symptoms and severity of these diseases vary dramatically, ranging from profound developmental delay to cancer predisposition and accelerated aging. All three syndromes include neurological disease, indicating an important role for NER in protecting against spontaneous DNA damage as well. To study the pathophysiology caused by DNA damage, numerous mouse models of NER deficiency were generated by knocking-out genes required for NER or knocking-in disease-causing human mutations. This review explores the utility of these mouse models to study neurological disease caused by NER deficiency. PMID:18272436

Karaya gum electrocardiographic electrodes for preterm infants.

PubMed Central

Cartlidge, P H; Rutter, N

1987-01-01

Changes in transepidermal water loss were used to measure skin damage caused by removal of electrocardiograph electrodes in 20 preterm infants. Electrodes secured by conventional adhesive damaged the skin, leading to a potentially dangerous increase in skin permeability. In contrast, those secured by karaya gum caused no skin damage. PMID:3435167

Root-cause estimation of ultrasonic scattering signatures within a complex textured titanium

NASA Astrophysics Data System (ADS)

Blackshire, James L.; Na, Jeong K.; Freed, Shaun

2016-02-01

The nondestructive evaluation of polycrystalline materials has been an active area of research for many decades, and continues to be an area of growth in recent years. Titanium alloys in particular have become a critical material system used in modern turbine engine applications, where an evaluation of the local microstructure properties of engine disk/blade components is desired for performance and remaining life assessments. Current NDE methods are often limited to estimating ensemble material properties or detecting localized voids, inclusions, or damage features within a material. Recent advances in computational NDE and material science characterization methods are providing new and unprecedented access to heterogeneous material properties, which permits microstructure-sensing interactions to be studied in detail. In the present research, Integrated Computational Materials Engineering (ICME) methods and tools are being leveraged to gain a comprehensive understanding of root-cause ultrasonic scattering processes occurring within a textured titanium aerospace material. A combination of destructive, nondestructive, and computational methods are combined within the ICME framework to collect, holistically integrate, and study complex ultrasound scattering using realistic 2-dimensional representations of the microstructure properties. Progress towards validating the computational sensing methods are discussed, along with insight into the key scattering processes occurring within the bulk microstructure, and how they manifest in pulse-echo immersion ultrasound measurements.

A comparative assessment of different frequency based damage detection in unidirectional composite plates using MFC sensors

NASA Astrophysics Data System (ADS)

de Medeiros, Ricardo; Sartorato, Murilo; Vandepitte, Dirk; Tita, Volnei

2016-11-01

The basic concept of the vibration based damage identification methods is that the dynamic behaviour of a structure can change if damage occurs. Damage in a structure can alter the structural integrity, and therefore, the physical properties like stiffness, mass and/or damping may change. The dynamic behaviour of a structure is a function of these physical properties and will, therefore, directly be affected by the damage. The dynamic behaviour can be described in terms of time, frequency and modal domain parameters. The changes in these parameters (or properties derived from these parameters) are used as indicators of damage. Hence, this work has two main objectives. The first one is to provide an overview of the structural vibration based damage identification methods. For this purpose, a fundamental description of the structural vibration based damage identification problem is given, followed by a short literature overview of the damage features, which are commonly addressed. The second objective is to create a damage identification method for detection of the damage in composite structures. To aid in this process, two basic principles are discussed, namely the effect of the potential damage case on the dynamic behaviour, and the consequences involved with the information reduction in the signal processing. Modal properties from the structural dynamic output response are obtained. In addition, experimental and computational results are presented for the application of modal analysis techniques applied to composite specimens with and without damage. The excitation of the structures is performed using an impact hammer and, for measuring the output data, accelerometers as well as piezoelectric sensors. Finite element models are developed by shell elements, and numerical results are compared to experimental data, showing good correlation for the response of the specimens in some specific frequency range. Finally, FRFs are analysed using suitable metrics, including a new one, which are compared in terms of their capability for damage identification. The experimental and numerical results show that the vibration-based damage methods combined to the metrics can be used in Structural Health Monitoring (SHM) systems to identify the damage in the structure.

Early diagnosis of teeth erosion using polarized laser speckle imaging

NASA Astrophysics Data System (ADS)

Nader, Christelle Abou; Pellen, Fabrice; Loutfi, Hadi; Mansour, Rassoul; Jeune, Bernard Le; Brun, Guy Le; Abboud, Marie

2016-07-01

Dental erosion starts with a chemical attack on dental tissue causing tooth demineralization, altering the tooth structure and making it more sensitive to mechanical erosion. Medical diagnosis of dental erosion is commonly achieved through a visual inspection by the dentist during dental checkups and is therefore highly dependent on the operator's experience. The detection of this disease at preliminary stages is important since, once the damage is done, cares become more complicated. We investigate the difference in light-scattering properties between healthy and eroded teeth. A change in light-scattering properties is observed and a transition from volume to surface backscattering is detected by means of polarized laser speckle imaging as teeth undergo acid etching, suggesting an increase in enamel surface roughness.

Mesenchymal stem cells and immunomodulation: current status and future prospects

PubMed Central

Gao, F; Chiu, S M; Motan, D A L; Zhang, Z; Chen, L; Ji, H-L; Tse, H-F; Fu, Q-L; Lian, Q

2016-01-01

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy. PMID:26794657

Identifying the impact of the built environment on flood damage in Texas.

PubMed

Brody, Samuel D; Zahran, Sammy; Highfield, Wesley E; Grover, Himanshu; Vedlitz, Arnold

2008-03-01

Floods continue to pose the greatest threat to the property and safety of human communities among all natural hazards in the United States. This study examines the relationship between the built environment and flood impacts in Texas, which consistently sustains the most damage from flooding of any other state in the country. Specifically, we calculate property damage resulting from 423 flood events between 1997 and 2001 at the county level. We identify the effect of several built environment measures, including wetland alteration, impervious surface, and dams on reported property damage while controlling for biophysical and socio-economic characteristics. Statistical results suggest that naturally occurring wetlands play a particularly important role in mitigating flood damage. These findings provide guidance to planners and flood managers on how to alleviate most effectively the costly impacts of foods at the community level.

In vitro immunotoxic and genotoxic activities of particles emitted from two different small-scale wood combustion appliances

NASA Astrophysics Data System (ADS)

Tapanainen, Maija; Jalava, Pasi I.; Mäki-Paakkanen, Jorma; Hakulinen, Pasi; Happo, Mikko S.; Lamberg, Heikki; Ruusunen, Jarno; Tissari, Jarkko; Nuutinen, Kati; Yli-Pirilä, Pasi; Hillamo, Risto; Salonen, Raimo O.; Jokiniemi, Jorma; Hirvonen, Maija-Riitta

2011-12-01

Residential wood combustion appliances emit large quantities of fine particles which are suspected to cause a substantial health burden worldwide. Wood combustion particles contain several potential health-damaging metals and carbon compounds such as polycyclic aromatic hydrocarbons (PAH), which may determine the toxic properties of the emitted particles. The aim of the present study was to characterize in vitro immunotoxicological and chemical properties of PM 1 ( Dp ≤ 1 μm) emitted from a pellet boiler and a conventional masonry heater. Mouse RAW264.7 macrophages were exposed for 24 h to different doses of the emission particles. Cytotoxicity, production of the proinflammatory cytokine TNF-α and the chemokine MIP-2, apoptosis and phases of the cell cycle as well as genotoxic activity were measured after the exposure. The type of wood combustion appliance had a significant effect on emissions and chemical composition of the particles. All the studied PM 1 samples induced cytotoxic, genotoxic and inflammatory responses in a dose-dependent manner. The particles emitted from the conventional masonry heater were 3-fold more potent inducers of programmed cell death and DNA damage than those emitted from the pellet boiler. Furthermore, the particulate samples that induced extensive DNA damage contained also large amounts of PAH compounds. Instead, significant differences between the studied appliances were not detected in measurements of inflammatory mediators, although the chemical composition of the combustion particles differed considerably from each other. In conclusion, the present results show that appliances representing different combustion technology have remarkable effects on physicochemical and associated toxicological and properties of wood combustion particles. The present data indicate that the particles emitted from incomplete combustion are toxicologically more potent than those emitted from more complete combustion processes.

Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model

PubMed Central

2014-01-01

Background Metal oxide nanoparticles such as ZnO are used in sunscreens as they improve their optical properties against the UV-light that causes dermal damage and skin cancer. However, the hazardous properties of the particles used as UV-filters in the sunscreens and applied to the skin have remained uncharacterized. Methods Here we investigated whether different sized ZnO particles would be able to penetrate injured skin and injured allergic skin in the mouse atopic dermatitis model after repeated topical application of ZnO particles. Nano-sized ZnO (nZnO) and bulk-sized ZnO (bZnO) were applied to mechanically damaged mouse skin with or without allergen/superantigen sensitization. Allergen/superantigen sensitization evokes local inflammation and allergy in the skin and is used as a disease model of atopic dermatitis (AD). Results Our results demonstrate that only nZnO is able to reach into the deep layers of the allergic skin whereas bZnO stays in the upper layers of both damaged and allergic skin. In addition, both types of particles diminish the local skin inflammation induced in the mouse model of AD; however, nZnO has a higher potential to suppress the local effects. In addition, especially nZnO induces systemic production of IgE antibodies, evidence of allergy promoting adjuvant properties for topically applied nZnO. Conclusions These results provide new hazard characterization data about the metal oxide nanoparticles commonly used in cosmetic products and provide new insights into the dermal exposure and hazard assessment of these materials in injured skin. PMID:25123235

7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 14 2013-01-01 2013-01-01 false Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer and...

7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer and...

7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 14 2014-01-01 2014-01-01 false Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer and...

7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 14 2012-01-01 2012-01-01 false Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer and...

7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer and...

10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been or...

10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been or...

10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been or...

10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been or...

Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view.

PubMed

Xu, Min; Heng, Paul Wan Sia; Liew, Celine Valeria

2016-02-29

Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage sustained during the preparation of MUPS tablets in a rotary tablet press. Blends containing ethylcellulose-coated pellets and cushioning agent (spray dried aggregates of micronized lactose and mannitol), were compacted into MUPS tablets in a rotary tablet press. The effects of compaction pressure and dwell time on the physicomechanical properties of resultant MUPS tablets and extent of pellet coat damage were systematically examined. The coated pellets from various locations at the axial and radial peripheral surfaces and core of the MUPS tablets were excavated and assessed for their coat damage individually. Interestingly, for a MUPS tablet formulation which consolidates by plastic deformation, the tablet mechanical strength could be enhanced without exacerbating pellet coat damage by extending the dwell time in the compaction cycle during rotary tableting. However, the increase in compaction pressure led to faster drug release rate. The location of the coated pellets in the MUPS tablet also contributed to the extent of their coat damage, possibly due to uneven force distribution within the compact. To ensure viability of pellet coat integrity, the formation of a continuous percolating network of cushioning agent is critical and the applied compaction pressure should be less than the pellet crushing strength. Copyright © 2015 Elsevier B.V. All rights reserved.

Earthquakes, May-June 1981

USGS Publications Warehouse

Person, W.J.

1981-01-01

The months of May and June were somewhat quiet, seismically speaking. There was one major earthquake (7.0-7.9) off the west coast of South Island, New Zealand. The most destructive earthquake during this reporting period was in southern Iran on June 11 which caused fatalities and extensive damage. Peru also experienced a destructive earthquake on June 22 which caused fatalities and damage. In the United States, a number of earthquakes were experienced, but none caused significant damage. 

32 CFR 842.7 - Who may file a claim.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ADMINISTRATIVE CLAIMS General Information § 842.7 Who may file a claim. (a) Property damage. The owner or owners of the property or their authorized agent may file a claim for property damage. (b) Personal injury... duly appointed guardian of a minor child or any other person legally entitled to do so under applicable...

32 CFR 842.7 - Who may file a claim.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ADMINISTRATIVE CLAIMS General Information § 842.7 Who may file a claim. (a) Property damage. The owner or owners of the property or their authorized agent may file a claim for property damage. (b) Personal injury... duly appointed guardian of a minor child or any other person legally entitled to do so under applicable...

32 CFR 842.7 - Who may file a claim.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ADMINISTRATIVE CLAIMS General Information § 842.7 Who may file a claim. (a) Property damage. The owner or owners of the property or their authorized agent may file a claim for property damage. (b) Personal injury... duly appointed guardian of a minor child or any other person legally entitled to do so under applicable...

32 CFR 842.7 - Who may file a claim.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ADMINISTRATIVE CLAIMS General Information § 842.7 Who may file a claim. (a) Property damage. The owner or owners of the property or their authorized agent may file a claim for property damage. (b) Personal injury... duly appointed guardian of a minor child or any other person legally entitled to do so under applicable...

32 CFR 842.7 - Who may file a claim.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ADMINISTRATIVE CLAIMS General Information § 842.7 Who may file a claim. (a) Property damage. The owner or owners of the property or their authorized agent may file a claim for property damage. (b) Personal injury... duly appointed guardian of a minor child or any other person legally entitled to do so under applicable...

14 CFR 1261.109 - Computation of allowance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... to the loss or damage of property lost or damaged beyond economical repair, less any salvage value... price paid in cash or property, or the value at the time of acquisition if not acquired by purchase or exchange). There will be no allowance for replacement cost or for appreciation in the value of the property...

24 CFR 17.48 - Computation of amount of award.

Code of Federal Regulations, 2011 CFR

2011-04-01

... loss or damage, of property lost or damaged beyond economical repair, less any salvage value; or (2... property, or the value at the time of acquisition if not acquired by purchase or exchange); and there will be no allowance for replacement cost or for appreciation in the value of the property. Subject to...

44 CFR 11.78 - Computation of amount of award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... in the value of the property. Subject to these limitations, the amount allowable is either: (1) The depreciated value, immediately prior to the loss or damage, of property lost or damaged beyond economical... the item (either the price paid in cash or property, or the value at the time of acquisition if not...

Efficacy of antioxidants in human hair.

PubMed

Fernández, Estibalitz; Martínez-Teipel, Blanca; Armengol, Ricard; Barba, Clara; Coderch, Luisa

2012-12-05

Hair is exposed every day to a range of harmful effects such as sunlight, pollution, cosmetic treatments, grooming practices and cleansing. The UV components of sunlight damage human hair, causing fibre degradation. UV-B attacks the melanin pigments and the protein fractions (keratin) of hair and UV-A produces free radical/reactive oxygen species (ROS) through the interaction of endogenous photosensitizers. Hair was dyed and the efficacy of two antioxidant formulations was demonstrated after UV exposure by evaluating, surface morphology, protein and amino acid degradation, lipidic peroxidation, colour and shine changes and strength/relaxation properties. UV treatment resulted in an increase in protein and lipid degradation, changes in colour and shine and in adverse consequences for the mechanical properties. Natural antioxidants obtained from artichoke and rice applied to pretreated hair improved mechanical properties and preserved colour and shine of fibres, coating them and protecting them against UV. Furthermore, the lipidic peroxidation of the protein degradation caused by UV was reduced for some treated fibres, suggesting an improvement in fibre integrity. This was more marked in the case of the fibres treated using the artichoke extract, whereas the rice extract was better preserving shine and colour of hair fibres. Copyright © 2012 Elsevier B.V. All rights reserved.

Mechanical properties of silicon in subsurface damage layer from nano-grinding studied by atomistic simulation

NASA Astrophysics Data System (ADS)

Zhang, Zhiwei; Chen, Pei; Qin, Fei; An, Tong; Yu, Huiping

2018-05-01

Ultra-thin silicon wafer is highly demanded by semi-conductor industry. During wafer thinning process, the grinding technology will inevitably induce damage to the surface and subsurface of silicon wafer. To understand the mechanism of subsurface damage (SSD) layer formation and mechanical properties of SSD layer, atomistic simulation is the effective tool to perform the study, since the SSD layer is in the scale of nanometer and hardly to be separated from underneath undamaged silicon. This paper is devoted to understand the formation of SSD layer, and the difference between mechanical properties of damaged silicon in SSD layer and ideal silicon. With the atomistic model, the nano-grinding process could be performed between a silicon workpiece and diamond tool under different grinding speed. To reach a thinnest SSD layer, nano-grinding speed will be optimized in the range of 50-400 m/s. Mechanical properties of six damaged silicon workpieces with different depths of cut will be studied. The SSD layer from each workpiece will be isolated, and a quasi-static tensile test is simulated to perform on the isolated SSD layer. The obtained stress-strain curve is an illustration of overall mechanical properties of SSD layer. By comparing the stress-strain curves of damaged silicon and ideal silicon, a degradation of Young's modulus, ultimate tensile strength (UTS), and strain at fracture is observed.

The Value of Wetlands in Protecting Southeast Louisiana from Hurricane Storm Surges

PubMed Central

Barbier, Edward B.; Georgiou, Ioannis Y.; Enchelmeyer, Brian; Reed, Denise J.

2013-01-01

The Indian Ocean tsunami in 2004 and Hurricanes Katrina and Rita in 2005 have spurred global interest in the role of coastal wetlands and vegetation in reducing storm surge and flood damages. Evidence that coastal wetlands reduce storm surge and attenuate waves is often cited in support of restoring Gulf Coast wetlands to protect coastal communities and property from hurricane damage. Yet interdisciplinary studies combining hydrodynamic and economic analysis to explore this relationship for temperate marshes in the Gulf are lacking. By combining hydrodynamic analysis of simulated hurricane storm surges and economic valuation of expected property damages, we show that the presence of coastal marshes and their vegetation has a demonstrable effect on reducing storm surge levels, thus generating significant values in terms of protecting property in southeast Louisiana. Simulations for four storms along a sea to land transect show that surge levels decline with wetland continuity and vegetation roughness. Regressions confirm that wetland continuity and vegetation along the transect are effective in reducing storm surge levels. A 0.1 increase in wetland continuity per meter reduces property damages for the average affected area analyzed in southeast Louisiana, which includes New Orleans, by $99-$133, and a 0.001 increase in vegetation roughness decreases damages by $24-$43. These reduced damages are equivalent to saving 3 to 5 and 1 to 2 properties per storm for the average area, respectively. PMID:23536815

The value of wetlands in protecting southeast louisiana from hurricane storm surges.

PubMed

Barbier, Edward B; Georgiou, Ioannis Y; Enchelmeyer, Brian; Reed, Denise J

2013-01-01

The Indian Ocean tsunami in 2004 and Hurricanes Katrina and Rita in 2005 have spurred global interest in the role of coastal wetlands and vegetation in reducing storm surge and flood damages. Evidence that coastal wetlands reduce storm surge and attenuate waves is often cited in support of restoring Gulf Coast wetlands to protect coastal communities and property from hurricane damage. Yet interdisciplinary studies combining hydrodynamic and economic analysis to explore this relationship for temperate marshes in the Gulf are lacking. By combining hydrodynamic analysis of simulated hurricane storm surges and economic valuation of expected property damages, we show that the presence of coastal marshes and their vegetation has a demonstrable effect on reducing storm surge levels, thus generating significant values in terms of protecting property in southeast Louisiana. Simulations for four storms along a sea to land transect show that surge levels decline with wetland continuity and vegetation roughness. Regressions confirm that wetland continuity and vegetation along the transect are effective in reducing storm surge levels. A 0.1 increase in wetland continuity per meter reduces property damages for the average affected area analyzed in southeast Louisiana, which includes New Orleans, by $99-$133, and a 0.001 increase in vegetation roughness decreases damages by $24-$43. These reduced damages are equivalent to saving 3 to 5 and 1 to 2 properties per storm for the average area, respectively.

Landscape changes have greater effects than climate changes on six insect pests in China.

PubMed

Zhao, Zihua; Sandhu, Hardev S; Ouyang, Fang; Ge, Feng

2016-06-01

In recent years, global changes are the major causes of frequent, widespread outbreaks of pests in mosaic landscapes, which have received substantial attention worldwide. We collected data on global changes (landscape and climate) and economic damage caused by six main insect pests during 1951-2010 in China. Landscape changes had significant effects on all six insect pests. Pest damage increased significantly with increasing arable land area in agricultural landscapes. However, climate changes had no effect on damage caused by pests, except for the rice leaf roller (Cnaphalocrocis medinalis Guenee) and armyworm (Mythimna separate (Walker)), which caused less damage to crops with increasing mean temperature. Our results indicate that there is slight evidence of possible offset effects of climate changes on the increasing damage from these two agricultural pests. Landscape changes have caused serious outbreaks of several species, which suggests the possibility of the use of landscape design for the control of pest populations through habitat rearrangement. Landscape manipulation may be used as a green method to achieve sustainable pest management with minimal use of insecticides and herbicides.

Fear based Education or Curiosity based Education as an Example of Earthquake and Natural Disaster Education: Results of Statistical Study in Primary Schools in Istanbul-Turkey

NASA Astrophysics Data System (ADS)

Ozcep, T.; Ozcep, F.

2012-04-01

Natural disaster reduction focuses on the urgent need for prevention activities to reduce loss of life, damage to property, infrastructure and environment, and the social and economic disruption caused by natural hazards. One of the most important factors in reduction of the potential damage of earthquakes is trained manpower. To understanding the causes of earthquakes and other natural phenomena (landslides, avalanches, floods, volcanoes, etc.) is one of the pre-conditions to show a conscious behavior. The aim of the study is to analysis and to investigate, how earthquakes and other natural phenomena are perceived by the students and the possible consequences of this perception, and their effects of reducing earthquake damage. One of the crucial questions is that is our education system fear or curiosity based education system? Effects of the damages due to earthquakes have led to look like a fear subject. In fact, due to the results of the effects, the earthquakes are perceived scary phenomena. In the first stage of the project, the learning (or perception) levels of earthquakes and other natural disasters for the students of primary school are investigated with a survey. Aim of this survey study of earthquakes and other natural phenomena is that have the students fear based or curiosity based approaching to the earthquakes and other natural events. In the second stage of the project, the path obtained by the survey are evaluated with the statistical point of approach. A questionnaire associated with earthquakes and natural disasters are applied to primary school students (that total number of them is approximately 700 pupils) to measure the curiosity and/or fear levels. The questionnaire consists of 17 questions related to natural disasters. The questions are: "What is the Earthquake ?", "What is power behind earthquake?", "What is the mental response during the earthquake ?", "Did we take lesson from earthquake's results ?", "Are you afraid of earthquake ?", "Could earthquake be predicted ?", "Does earthquake kill people or buildings ?", "What is fault?", "Who is earthquake scientist?", "Are the Moon, Sun and other planets caused the earthquake?", "Does the weather conditions trigger the earthquake?", "What is the cause of tsunami?", "What is cause of the flood?", " What is the cause of volcanic eruption?", "What is cause of the landslide?", "What is the cause of disasters?", "What is your feeling about the earthquake; curiosity or fear?". Answers of these questions are evaluated. In the result, the primary school students think that earthquakes and other events are both religious and scientific origin. As example; the answers of "What is your feeling about the earthquake; corusity or fear?" question are replied 81 % Fear and %19 Curiosity.

Design and comparison of laser windows for high-power lasers

NASA Astrophysics Data System (ADS)

Niu, Yanxiong; Liu, Wenwen; Liu, Haixia; Wang, Caili; Niu, Haisha; Man, Da

2014-11-01

High-power laser systems are getting more and more widely used in industry and military affairs. It is necessary to develop a high-power laser system which can operate over long periods of time without appreciable degradation in performance. When a high-energy laser beam transmits through a laser window, it is possible that the permanent damage is caused to the window because of the energy absorption by window materials. So, when we design a high-power laser system, a suitable laser window material must be selected and the laser damage threshold of the window must be known. In this paper, a thermal analysis model of high-power laser window is established, and the relationship between the laser intensity and the thermal-stress field distribution is studied by deducing the formulas through utilizing the integral-transform method. The influence of window radius, thickness and laser intensity on the temperature and stress field distributions is analyzed. Then, the performance of K9 glass and the fused silica glass is compared, and the laser-induced damage mechanism is analyzed. Finally, the damage thresholds of laser windows are calculated. The results show that compared with K9 glass, the fused silica glass has a higher damage threshold due to its good thermodynamic properties. The presented theoretical analysis and simulation results are helpful for the design and selection of high-power laser windows.

Effects of microscale damage evolution on piezoresistive sensing in nanocomposite bonded explosives under dynamic loading via electromechanical peridynamics

NASA Astrophysics Data System (ADS)

Prakash, Naveen; Seidel, Gary D.

2018-01-01

Polymer bonded explosives can sustain microstructural damage due to accidental impact, which may reduce their operational reliability or even cause unwanted ignition leading to detonation of the explosive. Therefore a nanocomposite piezoresistivity based sensing solution is discussed here that employs a carbon nanotube based nanocomposite binder in the explosive material by which in situ real-time sensing can be obtained. A coupled electromechanical peridynamics code is used to numerically obtain the piezoresistive response of such a material under dynamic conditions, which allows one to capture damage initiation and propagation mechanisms due to stress waves. The relative change in resistance at three locations along the length of the microstructure is monitored, and found to correlate well with deformation and damage mechanisms within the material. This response can depend on many factors, such as carbon nanotube content, electrical conductivity of the grain, impact velocity and fracture properties, which are explored through numerical simulations. For example, it is found that the piezoresistive response is highly dependent on preferential pathways of electrical current , i.e. the phase through which the current flows, which is in turn affected by the conductivity of the grain and the specific pattern of damage. It is found that the results qualitatively agree with experimental data on the dynamic piezoresistive response of nanocomposites and look promising as a sensing mechanism for explosive materials.

The effect of laser ablation parameters on optical limiting properties of silver nanoparticles

NASA Astrophysics Data System (ADS)

Gursoy, Irmak; Yaglioglu, Halime Gul

2017-09-01

This paper presents the effect of laser ablation parameters on optical limiting properties of silver nanoparticles. The current applications of lasers such as range finding, guidance, detection, illumination and designation have increased the potential of damaging optical imaging systems or eyes temporary or permanently. The applications of lasers introduce risks for sensors or eyes, when laser power is higher than damage threshold of the detection system. There are some ways to protect these systems such as neutral density (nd) filters, shutters, etc. However, these limiters reduce the total amount of light that gets into the system. Also, response time of these limiters may not be fast enough to prevent damage and cause precipitation in performance due to deprivation of transmission or contrast. Therefore, optical limiting filters are needed that is transparent for low laser intensities and limit or block the high laser intensities. Metal nanoparticles are good candidates for such optical limiting filters for ns pulsed lasers or CW lasers due to their high damage thresholds. In this study we investigated the optical limiting performances of silver nanoparticles produced by laser ablation technique. A high purity silver target immersed in pure water was ablated with a Nd:YAG nanosecond laser at 532 nm. The effect of altering laser power and ablation time on laser ablation efficiency of nanoparticles was investigated experimentally and optimum values were specified. Open aperture Zscan experiment was used to investigate the effect of laser ablation parameters on the optical limiting performances of silver nanoparticles in pure water. It was found that longer ablation time decreases the optical limiting threshold. These results are useful for silver nanoparticles solutions to obtain high performance optical limiters.

Flood of July 12-13, 2004, Burlington and Camden Counties, South-Central New Jersey

USGS Publications Warehouse

Protz, Amy R.; Reed, Timothy J.

2006-01-01

Intense rainfall inundated south-central New Jersey on July 12-13, 2004, causing major flooding with heavy property, road, and bridge damage in Burlington and Camden Counties. Forty-five dams were topped or damaged, or failed completely. The affected areas were in the Rancocas Creek, Cooper River, and Pennsauken Creek Basins. The U.S. Geological Survey (USGS) documented peak stream elevations and flows at 56 selected sites within the affected area. With rainfall totals averaging more than 6 inches throughout the three basins, peak-of-record flood elevations and streamflows occurred at all but one USGS stream gage, where the previous record was tied. Flood-frequency recurrence-intervals ranged from 30 to greater than 100 years and maximum streamflow per square mile ranged from 13.9 to 263 cubic feet per second per square mile (ft3/s/mi2). Peak streamflow at USGS stream gages surrounding the affected basins are associated with considerably lower recurrence intervals and demonstrate the limited extent of the flood. A high tide of about 1 foot above monthly mean high tide did not contribute to high-water conditions. Low ground-water levels prior to the rainfall helped to mitigate flooding in the affected basins. Compared with historical floods in the Rancocas Creek Basin during 1938-40, the July 2004 flood had greater streamflow, but lower stream elevations. Property damage from the event was estimated at $50 million. Governor James E. McGreevy declared a State of Emergency in Burlington and Camden Counties on July 13, 2004. After assessment of the damage by the Federal Emergency Management Agency (FEMA), President George W. Bush declared Burlington and Camden Counties disaster areas on July 16, 2004.

ANALYSIS FOR HOUSE DAMAGE PROPERTY OF 2007 MID-NIIGATA PREFECTURE OFFSHORE EARTHQUAKE

NASA Astrophysics Data System (ADS)

Ochiai, Hirokazu; Yamada, Kento; Ohtsuka, Satoru; Isobe, Koichi

This paper reports the result of correlation analysis for house damage in 2007 Mid-piigata prefecture offshore earthquake by focusing geomorphological land classification and other factors as landform and ground properties with organizing the house damage data of disaster victim certificate conducted by public administrations. In former part of the paper, the features of house damage at 2007 Mid-Niigata prefecture offshore earthquake were analyzed for various influencing factors. The authors discussed the affrecting factors to houses at earthquake. In latter part, the features of house damage at 2007 Mid-Niigata prefecture offshore earthquake was discussed with that at 2004 Mid-Niigata prefecture earthquake. The house damage function of distance from the epicenter was proposed based on the analysis on house damage ratio recorded in two earthquakes.

Beyond the basics: lightning-strike injuries.

PubMed

Mistovich, Joseph J; Krost, William S; Limmer, Daniel D

2008-03-01

It is estimated that a lightning flash occurs approximately 8 million times per day throughout the world. Most strikes are benign and cause little damage to property and physical structures; however, when lightning strikes a person or group of people, it is a significant medical and potentially traumatic event that could lead to immediate death or permanent disability. By understanding some basic physics of lightning and pathophysiology of injuries associated with lightning strikes, EMS providers will be better prepared to identify assessment findings, anticipate complications and provide effective emergency care.

The Basal Ganglia and Adaptive Motor Control

NASA Astrophysics Data System (ADS)

Graybiel, Ann M.; Aosaki, Toshihiko; Flaherty, Alice W.; Kimura, Minoru

1994-09-01

The basal ganglia are neural structures within the motor and cognitive control circuits in the mammalian forebrain and are interconnected with the neocortex by multiple loops. Dysfunction in these parallel loops caused by damage to the striatum results in major defects in voluntary movement, exemplified in Parkinson's disease and Huntington's disease. These parallel loops have a distributed modular architecture resembling local expert architectures of computational learning models. During sensorimotor learning, such distributed networks may be coordinated by widely spaced striatal interneurons that acquire response properties on the basis of experienced reward.

Protective effect of Selenium nanoparticle against cyclophosphamide induced hepatotoxicity and genotoxicity in Swiss albino mice.

PubMed

Bhattacharjee, Arin; Basu, Abhishek; Ghosh, Prosenjit; Biswas, Jaydip; Bhattacharya, Sudin

2014-08-01

Cyclophosphamide (CP) is the most commonly used chemotherapeutic drug for various types of cancer. However, its use causes severe cytotoxicity to normal cells in human. It is well known that the undesirable side effects are caused due to the formation of reactive oxygen species. Selenium is an essential micronutrient for both animals and humans and has antioxidant and membrane stabilizing property, but selenium is also toxic above certain level. Nano selenium has been well proved to be less toxic than inorganic selenium as well as certain organoselenium compounds. The objective of the study is to evaluate the protective role of Nano-Se against CP-induced hepatotoxicity and genotoxicity in Swiss albino mice. CP was administered intraperitoneally (25 mg/kg b.w.) and Nano-Se was given by oral gavages (2 mg Se/kg b.w.) in concomitant and pretreatment scheme. Intraperitoneal administration of CP induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases and increased the malonaldehyde level, depleted the glutathione content and antioxidant enzyme activity (glutathione peroxidase, glutathione-s-transferase, superoxide dismutase and catalase), and induced DNA damage and chromosomal aberration. Oral administration of Nano-Se caused a significant reduction in malonaldehyde, ROS level and glutathione levels, restoration of antioxidant enzyme activity, reduction in chromosomal aberration in bone marrow, and DNA damage in lymphocytes and also in bone marrow. Moreover, the chemoprotective efficiency of Nano-Se against CP induced toxicity was confirmed by histopathological evaluation. The results support the protective effect of Nano-Se against CP-induced hepatotoxicity and genotoxicity. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Bile-acid-induced cell injury and protection

PubMed Central

Perez, Maria J; Briz, Oscar

2009-01-01

Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involving oxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N-methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties. PMID:19360911

Conventional (MG-BR46 Conquista) and transgenic (BRS Valiosa RR) soybeans have no mutagenic effects and may protect against induced-DNA damage in vivo.

PubMed

Venâncio, Vinicius P; Silva, João Paulo L; Almeida, Alaor A; Brigagão, Maísa R P L; Azevedo, Luciana

2012-01-01

In the present study, we evaluated the pesticide and metal concentrations as well as the antimutagenic and mutagenic properties of commercial soybeans (Glycine max). Male Swiss mice were fed diets containing 1%, 10%, or 20% (w/w) transgenic soybeans (BRS Valiosa RR) or parental isogenic conventional soybeans (MG-BR46 Conquista). Cyclophosphamide (50 mg kg⁻¹ b.w.) was added in a single dose 24 h before euthanasia as an induction agent. There was no difference in the composition (ash, total fat, protein, moisture, and carbohydrates) of the diets containing the same soybean concentration. The results show that the commercially available Brazilian soybeans tested are free of organochlorine, organophosphate, and carbamate pesticides and contain acceptable heavy metal concentrations. Both cyclophosphamide and soybean treatments were not sufficient to cause detectable oxidative damage on liver by the levels of malondialdehyde and protein carbonyl. The transgenic soybeans are also nonmutagenic and have protective effects against DNA damage similar to those of conventional soybeans but to a lesser percentage (64%-101% for conventional and 23%-33% for transgenic diets).

Modeling of karst deformation and analysis of acoustic emission during sinkhole formation

NASA Astrophysics Data System (ADS)

Bakeev, R. A.; Stefanov, Yu. P.; Duchkov, A. A.; Myasnikov, A. V.

2017-12-01

In this paper, the fracture pattern and formation of a sinkhole are estimated depending on the rock properties. The possibility of using geophysical methods for recording and analyzing acoustic emission to monitor and predict the state of the medium is considered. The problem of deformation of the sedimentary cover over the growing karst cavity is solved on the basis of the elastoplastic Drucker-Prager-Nikolaevsky model and the equation of damage accumulation. The specified kinetics of accumulation of damages allows us to describe slow processes of degradation of the strength of the medium under stresses that are low for the development of inelastic deformations. The results are obtained for different values of the strength of karst rock; we show the influence of the kinetic parameters of damage accumulation on the shape of collapse depressions. We also model acoustic emission caused by the material fracture. One can follow different stages of the karst development by looking at patterns of cells which fail at a given time. Our observations show the relation between the intensity of material fracture and the intensity of seismic emission.

Interaction of gases with lunar materials. [surface properties of lunar fines, especially on exposure to water vapor

NASA Technical Reports Server (NTRS)

Holmes, H. F.; Gammage, R. B.

1975-01-01

The surface properties of lunar fines were investigated. Results indicate that, for the most part, these properties are independent of the chemical composition and location of the samples on the lunar surface. The leaching of channels and pores by adsorbed water vapor is a distinguishing feature of their surface chemistry. The elements of air, if adsorbed in conjunction with water vapor or liquid water, severely impedes the leaching process. In the absence of air, liquid water is more effective than water vapor in attacking the grains. The characteristics of Apollo 17 orange fines were evaluated and compared with those of other samples. The interconnecting channels produced by water vapor adsorption were found to be wider than usual for other types of fines. Damage tracks caused by heavy cosmic ray nuclei and an unusually high halogen content might provide for stronger etching conditions upon exposure to water vapor.

Economic impacts of the ShakeOut scenario

USGS Publications Warehouse

Rose, A.; Wei, D.; Wein, A.

2011-01-01

For the ShakeOut Earthquake Scenario, we estimate $68 billion in direct and indirect business interruption (BI) and $11 billion in related costs in addition to the $113 billion in property damage in an eight-county Southern California region. The modeled conduits of shock to the economy are property damage and lifeline service outages that affect the economy’s ability to produce. Property damage from fire is 50% greater than property damage from shaking because fire is more devastating. BI from water service disruption and fire each represent around one-third of total BI losses because of the long duration of service outage or long restoration and reconstruction periods. Total BI losses are 4.3% of annual gross output in the affected region, an impact far larger than most conventional economic recessions. These losses are still much lower than they potentially could be due to the resilience of the economy.