Coherent beam combining performance in harsh environment

NASA Astrophysics Data System (ADS)

Lombard, L.; Canat, G.; Durecu, A.; Bourdon, P.

2014-03-01

Coherent beam combining (CBC) is a promising solution for high power directed energy weapons. We investigate several particular issues for this application: First, we study the evolution of phase noise spectrum for increasing pump power in 100 W MOPFA. The main variations in the spectrum are located in the low frequency region corresponding to thermal transfer between the fiber core heated by the pump absorption and the fiber environment. The phase noise root mean square evolves linearly with the pump power. Noise spectrum is not shifted to higher frequencies. Second, we investigate the influence of fiber packaging and amplifier packaging on the phase noise and estimate the LOCSET controller bandwidth (BW) requirement in each case. Results show large variation of BW depending on the packaging, and not on the power. Then, we investigate the performances of CBC in harsh environment. For this purpose, we implement CBC of a 20-W fiber amplifier and a passive fiber using the LOCSET technique and simulate harsh environment by applying strong vibrations with a hammering drill on the optical table. The applied vibration spectrum ranges from 1 Hz to ~10 kHz with a standard deviation of 9 m/s2. CBC of the amplifier output and the passive fiber output is performed on a second table, isolated from vibrations. Measurements of the phase difference between both outputs and of the applied vibrations are simultaneously performed. Residual phase error of λ/40 (i.e. > 99 % CBC efficiency) is achieved under strong vibrations at 20 W. The -3 dB bandwidth of the LOCSET controller has been measured to be ~4.5 kHz. Results are in agreement with simulations.

The PyCBC search for compact binary mergers in the second run of Advanced LIGO

NASA Astrophysics Data System (ADS)

Dal Canton, Tito; PyCBC Team

2017-01-01

The PyCBC software implements a matched-filter search for gravitational-wave signals associated with mergers of compact binaries. During the first observing run of Advanced LIGO, it played a fundamental role in the discovery of the binary-black-hole merger signals GW150914, GW151226 and LVT151012. In preparation for Advanced LIGO's second run, PyCBC has been modified with the goal of increasing the sensitivity of the search, reducing its computational cost and expanding the explored parameter space. The ability to report signals with a latency of tens of seconds and to perform inference on the parameters of the detected signals has also been introduced. I will give an overview of PyCBC and present the new features and their impact.

Coherent beam combining of collimated fiber array based on target-in-the-loop technique

NASA Astrophysics Data System (ADS)

Li, Xinyang; Geng, Chao; Zhang, Xiaojun; Rao, Changhui

2011-11-01

Coherent beam combining (CBC) of fiber array is a promising way to generate high power and high quality laser beams. Target-in-the-loop (TIL) technique might be an effective way to ensure atmosphere propagation compensation without wavefront sensors. In this paper, we present very recent research work about CBC of collimated fiber array using TIL technique at the Key Lab on Adaptive Optics (KLAO), CAS. A novel Adaptive Fiber Optics Collimator (AFOC) composed of phase-locking module and tip/tilt control module was developed. CBC experimental setup of three-element fiber array was established. Feedback control is realized using stochastic parallel gradient descent (SPGD) algorithm. The CBC based on TIL with piston and tip/tilt correction simultaneously is demonstrated. And the beam pointing to locate or sweep position of combined spot on target was achieved through TIL technique too. The goal of our work is achieve multi-element CBC for long-distance transmission in atmosphere.

High Temperature Water Heat Pipes Radiator for a Brayton Space Reactor Power System

NASA Astrophysics Data System (ADS)

El-Genk, Mohamed S.; Tournier, Jean-Michel

2006-01-01

A high temperature water heat pipes radiator design is developed for a space power system with a sectored gas-cooled reactor and three Closed Brayton Cycle (CBC) engines, for avoidance of single point failures in reactor cooling and energy conversion and rejection. The CBC engines operate at turbine inlet and exit temperatures of 1144 K and 952 K. They have a net efficiency of 19.4% and each provides 30.5 kWe of net electrical power to the load. A He-Xe gas mixture serves as the turbine working fluid and cools the reactor core, entering at 904 K and exiting at 1149 K. Each CBC loop is coupled to a reactor sector, which is neutronically and thermally coupled, but hydraulically decoupled to the other two sectors, and to a NaK-78 secondary loop with two water heat pipes radiator panels. The segmented panels each consist of a forward fixed segment and two rear deployable segments, operating hydraulically in parallel. The deployed radiator has an effective surface area of 203 m2, and when the rear segments are folded, the stowed power system fits in the launch bay of the DELTA-IV Heavy launch vehicle. For enhanced reliability, the water heat pipes operate below 50% of their wicking limit; the sonic limit is not a concern because of the water, high vapor pressure at the temperatures of interest (384 - 491 K). The rejected power by the radiator peaks when the ratio of the lengths of evaporator sections of the longest and shortest heat pipes is the same as that of the major and minor widths of the segments. The shortest and hottest heat pipes in the rear segments operate at 491 K and 2.24 MPa, and each rejects 154 W. The longest heat pipes operate cooler (427 K and 0.52 MPa) and because they are 69% longer, reject more power (200 W each). The longest and hottest heat pipes in the forward segments reject the largest power (320 W each) while operating at ~ 46% of capillary limit. The vapor temperature and pressure in these heat pipes are 485 K and 1.97 MPa. By contrast, the shortest water heat pipes in the forward segments operate much cooler (427 K and 0.52 MPa), and reject a much lower power of 45 W each. The radiator with six fixed and 12 rear deployable segments rejects a total of 324 kWth, weights 994 kg and has an average specific power of 326 Wth/kg and a specific mass of 5.88 kg/m2.

Preliminary assessment of rover power systems for the Mars Rover Sample Return Mission

NASA Technical Reports Server (NTRS)

Bents, David J.

1989-01-01

Four isotope power system concepts were presented and compared on a common basis for application to on-board electrical prime power for an autonomous planetary rover vehicle. A representative design point corresponding to the Mars Rover Sample Return (MRSR) preliminary mission requirements (500 W) was selected for comparison purposes. All systems concepts utilize the General Purpose Heat Source (GPHS) isotope heat source developed by DOE. Two of the concepts employ thermoelectric (TE) conversion: one using the GPHS Radioisotope Thermoelectric Generator (RTG) used as a reference case, the other using an advanced RTG with improved thermoelectric materials. The other two concepts employed are dynamic isotope power systems (DIPS): one using a closed Brayton cycle (CBC) turboalternator, and the other using a free piston Stirling cycle engine/linear alternator (FPSE) with integrated heat source/heater head. Near term technology levels have been assumed for concept characterization using component technology figure-of-merit values taken from the published literature. For example, the CBC characterization draws from the historical test database accumulated from space Brayton cycle subsystems and components from the NASA B engine through the mini-Brayton rotating unit. TE system performance is estimated from Voyager/multihundred Watt (MHW)-RTG flight experience through Mod-RTG performance estimates considering recent advances in TE materials under the DOD/DOE/NASA SP-100 and NASA Committee on Scientific and Technological Information programs. The Stirling DIPS system is characterized from scaled-down Space Power Demonstrator Engine (SPDE) data using the GPHS directly incorporated into the heater head. The characterization/comparison results presented here differ from previous comparison of isotope power (made for Low Earth Orbit (LEO) applications) because of the elevated background temperature on the Martian surface compared to LEO, and the higher sensitivity of dynamic systems to elevated sink temperature. The mass advantage of dynamic systems is significantly reduced for this application due to Mars' elevated background temperature.

Heat Rejection Concepts for Brayton Power Conversion Systems

NASA Technical Reports Server (NTRS)

Siamidis, John; Mason, Lee; Beach, Duane; Yuko, James

2005-01-01

This paper describes potential heat rejection design concepts for closed Brayton cycle (CBC) power conversion systems. Brayton conversion systems are currently under study by NASA for Nuclear Electric Propulsion (NEP) applications. The Heat Rejection Subsystem (HRS) must dissipate waste heat generated by the power conversion system due to inefficiencies in the thermal-to-electric conversion process. Space Brayton conversion system designs tend to optimize at efficiencies of about 20 to 25 percent with radiator temperatures in the 400 to 600 K range. A notional HRS was developed for a 100 kWe-class Brayton power system that uses a pumped sodium-potassium (NaK) heat transport loop coupled to a water heat pipe radiator. The radiator panels employ a sandwich construction consisting of regularly-spaced circular heat pipes contained within two composite facesheets. Heat transfer from the NaK fluid to the heat pipes is accomplished by inserting the evaporator sections into the NaK duct channel. The paper evaluates various design parameters including heat pipe diameter, heat pipe spacing, and facesheet thickness. Parameters were varied to compare design options on the basis of NaK pump pressure rise and required power, heat pipe unit power and radial flux, radiator panel areal mass, and overall HRS mass.

Application of Multivariate Modeling for Radiation Injury Assessment: A Proof of Concept

PubMed Central

Bolduc, David L.; Villa, Vilmar; Sandgren, David J.; Ledney, G. David; Blakely, William F.; Bünger, Rolf

2014-01-01

Multivariate radiation injury estimation algorithms were formulated for estimating severe hematopoietic acute radiation syndrome (H-ARS) injury (i.e., response category three or RC3) in a rhesus monkey total-body irradiation (TBI) model. Classical CBC and serum chemistry blood parameters were examined prior to irradiation (d 0) and on d 7, 10, 14, 21, and 25 after irradiation involving 24 nonhuman primates (NHP) (Macaca mulatta) given 6.5-Gy 60Co Υ-rays (0.4 Gy min−1) TBI. A correlation matrix was formulated with the RC3 severity level designated as the “dependent variable” and independent variables down selected based on their radioresponsiveness and relatively low multicollinearity using stepwise-linear regression analyses. Final candidate independent variables included CBC counts (absolute number of neutrophils, lymphocytes, and platelets) in formulating the “CBC” RC3 estimation algorithm. Additionally, the formulation of a diagnostic CBC and serum chemistry “CBC-SCHEM” RC3 algorithm expanded upon the CBC algorithm model with the addition of hematocrit and the serum enzyme levels of aspartate aminotransferase, creatine kinase, and lactate dehydrogenase. Both algorithms estimated RC3 with over 90% predictive power. Only the CBC-SCHEM RC3 algorithm, however, met the critical three assumptions of linear least squares demonstrating slightly greater precision for radiation injury estimation, but with significantly decreased prediction error indicating increased statistical robustness. PMID:25165485

System Mass Variation and Entropy Generation in 100k We Closed-Brayton-Cycle Space Power Systems

NASA Technical Reports Server (NTRS)

Barrett, Michael J.; Reid, Bryan M.

2004-01-01

State-of-the-art closed-Brayton-cycle (CBC) space power systems were modeled to study performance trends in a trade space characteristic of interplanetary orbiters. For working-fluid molar masses of 48.6, 39.9, and 11.9 kg/kmol, peak system pressures of 1.38 and 3.0 MPa and compressor pressure ratios ranging from 1.6 to 2.4, total system masses were estimated. System mass increased as peak operating pressure increased for all compressor pressure ratios and molar mass values examined. Minimum mass point comparison between 72 percent He at 1.38 MPa peak and 94 percent He at 3.0 MPa peak showed an increase in system mass of 14 percent. Converter flow loop entropy generation rates were calculated for 1.38 and 3.0 MPa peak pressure cases. Physical system behavior was approximated using a pedigreed NASA Glenn modeling code, Closed Cycle Engine Program (CCEP), which included realistic performance prediction for heat exchangers, radiators and turbomachinery.

System Mass Variation and Entropy Generation in 100-kWe Closed-Brayton-Cycle Space Power Systems

NASA Technical Reports Server (NTRS)

Barrett, Michael J.; Reid, Bryan M.

2004-01-01

State-of-the-art closed-Brayton-cycle (CBC) space power systems were modeled to study performance trends in a trade space characteristic of interplanetary orbiters. For working-fluid molar masses of 48.6, 39.9, and 11.9 kg/kmol, peak system pressures of 1.38 and 3.0 MPa and compressor pressure ratios ranging from 1.6 to 2.4, total system masses were estimated. System mass increased as peak operating pressure increased for all compressor pressure ratios and molar mass values examined. Minimum mass point comparison between 72 percent He at 1.38 MPa peak and 94 percent He at 3.0 MPa peak showed an increase in system mass of 14 percent. Converter flow loop entropy generation rates were calculated for 1.38 and 3.0 MPa peak pressure cases. Physical system behavior was approximated using a pedigreed NASA Glenn modeling code, Closed Cycle Engine Program (CCEP), which included realistic performance prediction for heat exchangers, radiators and turbomachinery.

Dual-mode, high energy utilization system concept for mars missions

NASA Astrophysics Data System (ADS)

El-Genk, Mohamed S.

2000-01-01

This paper describes a dual-mode, high energy utilization system concept based on the Pellet Bed Reactor (PeBR) to support future manned missions to Mars. The system uses proven Closed Brayton Cycle (CBC) engines to partially convert the reactor thermal power to electricity. The electric power generated is kept the same during the propulsion and the power modes, but the reactor thermal power in the former could be several times higher, while maintaining the reactor temperatures almost constant. During the propulsion mode, the electric power of the system, minus ~1-5 kWe for house keeping, is used to operate a Variable Specific Impulse Magnetoplasma Rocket (VASIMR). In addition, the reactor thermal power, plus more than 85% of the head load of the CBC engine radiators, are used to heat hydrogen. The hot hydrogen is mixed with the high temperature plasma in a VASIMR to provide both high thrust and Isp>35,000 N.s/kg, reducing the travel time to Mars to about 3 months. The electric power also supports surface exploration of Mars. The fuel temperature and the inlet temperatures of the He-Xe working fluid to the nuclear reactor core and the CBC turbine are maintained almost constant during both the propulsion and power modes to minimize thermal stresses. Also, the exit temperature of the He-Xe from the reactor core is kept at least 200 K below the maximum fuel design temperature. The present system has no single point failure and could be tested fully assembled in a ground facility using electric heaters in place of the nuclear reactor. Operation and design parameters of a 40-kWe prototype are presented and discussed to illustrate the operation and design principles of the proposed system. .

Coherent beam combining architectures for high power tapered laser arrays

NASA Astrophysics Data System (ADS)

Schimmel, G.; Janicot, S.; Hanna, M.; Decker, J.; Crump, P.; Erbert, G.; Witte, U.; Traub, M.; Georges, P.; Lucas-Leclin, G.

2017-02-01

Coherent beam combining (CBC) aims at increasing the spatial brightness of lasers. It consists in maintaining a constant phase relationship between different emitters, in order to combine them constructively in one single beam. We have investigated the CBC of an array of five individually-addressable high-power tapered laser diodes at λ = 976 nm, in two architectures: the first one utilizes the self-organization of the lasers in an interferometric extended-cavity, which ensures their mutual coherence; the second one relies on the injection of the emitters by a single-frequency laser diode. In both cases, the coherent combining of the phase-locked beams is ensured on the front side of the array by a transmission diffractive grating with 98% efficiency. The passive phase-locking of the laser bar is obtained up to 5 A (per emitter). An optimization algorithm is implemented to find the proper currents in the five ridge sections that ensured the maximum combined power on the front side. Under these conditions we achieve a maximum combined power of 7.5 W. In the active MOPA configuration, we can increase the currents in the tapered sections up to 6 A and get a combined power of 11.5 W, corresponding to a combining efficiency of 76%. It is limited by the beam quality of the tapered emitters and by fast phase fluctuations between emitters. Still, these results confirm the potential of CBC approaches with tapered lasers to provide a high-power and high-brightness beam, and compare with the current state-of-the-art with laser diodes.

Multi-aperture all-fiber active coherent beam combining for free-space optical communication receivers.

PubMed

Yang, Yan; Geng, Chao; Li, Feng; Huang, Guan; Li, Xinyang

2017-10-30

Multi-aperture receiver with optical combining architecture is an effective approach to overcome the turbulent atmosphere effect on the performance of the free-space optical (FSO) communications, in which how to combine the multiple laser beams received by the sub-apertures efficiently is one of the key technologies. In this paper, we focus on the combining module based on fiber couplers, and propose the all-fiber coherent beam combining (CBC) with two architectures by using active phase locking. To validate the feasibility of the proposed combining module, corresponding experiments and simulations on the CBC of four laser beams are carried out. The experimental results show that the phase differences among the input beams can be compensated and the combining efficiency can be stably promoted by active phase locking in CBC with both of the two architectures. The simulation results show that the combining efficiency fluctuates when turbulent atmosphere is considered, and the effectiveness of the combining module decreases as the turbulence increases. We believe that the combining module proposed in this paper has great potential, and the results can provide significant advices for researchers when building such a multi-aperture receiver with optical combining architecture for FSO commutation systems.

Fuel assembly design for APR1400 with low CBC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hah, Chang Joo, E-mail: changhah@kings.ac.kr

2015-04-29

APR 1400 is a PWR (Pressurized Water Reactor) with rated power of 3983 MWth and 241 assemblies. Recently, demand for extremely longer cycle up to 24 months is increasing with challenge of higher critical boron concentration (CBC). In this paper, assembly design method of selecting Gd-rods is introduced to reduce CBC. The purpose of the method is to lower the critical boron concentration of the preliminary core loading pattern (PLP), and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). In this method, both the ratio of the number of low-Gd rod to the number of high-Gdmore » rod (r) and assembly average Gd wt% (w) are the decision variables. The target function is the amount of soluble boron concentration reduction, which can be converted to Δk{sub TARGET}. A set of new designed fuel assembly satisfies an objective function, min [f=∑{sub i}(Δk{sub FA}−Δk{sub i})], and enables a final loading pattern to reach a target CBC. The constraints required to determine a set of Δk are physically realizable pair, (r,w), and the sum of Δk of new designed assemblies as close to Δk{sub TARGET} as possible. New Gd-bearing assemblies selected based on valid pairs of (r,w) are replaced with existing assemblies in a PLP. This design methodology is applied to Shin-Kori Unit 3 Cycle 1 used as a reference model. CASMO-3/MASTER code is used for depletion calculation. CASMO-3/MASTER calculations with new designed assemblies produce lower CBC than the expected CBC, proving that the proposed method works successful.« less

Brayton Power Conversion System Parametric Design Modelling for Nuclear Electric Propulsion

NASA Technical Reports Server (NTRS)

Ashe, Thomas L.; Otting, William D.

1993-01-01

The parametrically based closed Brayton cycle (CBC) computer design model was developed for inclusion into the NASA LeRC overall Nuclear Electric Propulsion (NEP) end-to-end systems model. The code is intended to provide greater depth to the NEP system modeling which is required to more accurately predict the impact of specific technology on system performance. The CBC model is parametrically based to allow for conducting detailed optimization studies and to provide for easy integration into an overall optimizer driver routine. The power conversion model includes the modeling of the turbines, alternators, compressors, ducting, and heat exchangers (hot-side heat exchanger and recuperator). The code predicts performance to significant detail. The system characteristics determined include estimates of mass, efficiency, and the characteristic dimensions of the major power conversion system components. These characteristics are parametrically modeled as a function of input parameters such as the aerodynamic configuration (axial or radial), turbine inlet temperature, cycle temperature ratio, power level, lifetime, materials, and redundancy.

A comparison of energy conversion systems for meeting the power requirements of manned rover for Mars missions

NASA Technical Reports Server (NTRS)

El-Genk, Mohamed S.; Morley, Nicholas; Cataldo, Robert; Bloomfield, Harvey

1990-01-01

Several types of conversion systems of interest for a nuclear Mars manned application are examined, including: free-piston Stirling engines (FPSE), He/Xe closed Brayton cycle (CBC), CO2 open Brayton, and SiGe/GaP thermoelectric systems. Optimization studies were conducted to determine the impact of the conversion system on the overall mass of the nuclear power system and the mobility power requirement of the rover vehicle. The results of an analysis of a manned Mars rover equipped with a nuclear reactor power system show that the free-piston Stirling engine and the He/Xe closed Brayton cycle are the best available options for minimizing the overall mass and electric power requirements of the rover vehicle. While the current development of Brayton technology is further advanced than that of FPSE, the FPSE could provide approximately 13.5 percent lower mass than the He/Xe closed Brayton system. Results show that a specific mass of 160 is achievable with FPSE, for which the mass of the radiation shield (2.8 tons) is about half that for He/Xe CBC (5 tons).

Solar dynamic power for Space Station Freedom

NASA Technical Reports Server (NTRS)

Labus, Thomas L.; Secunde, Richard R.; Lovely, Ronald G.

1989-01-01

The Space Station Freedom Program is presently planned to consist of two phases. At the completion of Phase 1, Freedom's manned base will consist of a transverse boom with attached manned modules and 75 kW of available electric power supplied by photovoltaic (PV) power sources. In Phase 2, electric power available to the manned base will be increased to 125 kW by the addition of two solar dynamic (SD) power modules, one at each end of the transverse boom. Power for manned base growth beyond Phase 2 will be supplied by additional SD modules. Studies show that SD power for the growth eras will result in life cycle cost savings of $3 to $4 billion when compared to PV-supplied power. In the SD power modules for Space Station Freedom, an offset parabolic concentrator collects and focuses solar energy into a heat receiver. To allow full power operation over the entire orbit, the receiver includes integral thermal energy storage by means of the heat of fusion of a salt mixture. Thermal energy is removed from the receiver and converted to electrical energy by a power conversion unit (PCU) which includes a closed brayton cycle (CBC) heat engine and an alternator. The receiver/PCU/radiator combination will be completely assembled and charged with gas and cooling fluid on earth before launch to orbit. The concentrator subassemblies will be pre-aligned and stowed in the orbiter bay before launch. On orbit, the receiver/PCU/radiator assembly will be installed as a unit. The pre-aligned concentrator panels will then be latched together and the total concentrator attached to the receiver/PCU/radiator by the astronauts. After final electric connections are made and checkout is complete, the SD power module will be ready for operation.

Solar dynamic power for space station freedom

NASA Technical Reports Server (NTRS)

Labus, Thomas L.; Secunde, Richard R.; Lovely, Ronald G.

1989-01-01

The Space Station Freedom Program is presently planned to consist of two phases. At the completion of Phase 1, Freedom's manned base will consist of a transverse boom with attached manned modules and 75 kW of available electric power supplied by photovoltaic (PV) power sources. In Phase 2, electric power available to the manned base will be increased to 125 kW by the addition of two solar dynamic (SD) power modules, one at each end of the transverse boom. Power for manned base growth beyond Phase 2 will be supplied by additional SD modules. Studies show that SD power for the growth eras will result in life cycle cost savings of $3 to $4 billion when compared to PV-supplied power. In the SD power modules for Space Station Freedom, an offset parabolic concentrator collects and focuses solar energy into a heat receiver. To allow full power operation over the entire orbit, the receiver includes integral thermal energy storage by means of the heat of fusion of a salt mixture. Thermal energy is removed from the receiver and converted to electrical energy by a power conversion unit (PCU) which includes a closed brayton cycle (CBC) heat engine and an alternator. The receiver/PCU/radiator combination will be completely assembled and charged with gas and cooling fluid on Earth before launch to orbit. The concentrator subassemblies will be pre-aligned and stowed in the orbiter bay before launch. On orbit, the receiver/PCU/radiator assembly will be installed as a unit. The pre-aligned concentrator panels will then be latched together and the total concentrator attached to the receiver/PCU/radiator by the astronauts. After final electric connections are made and checkout is complete, the SD power module will be ready for operation.

Biomass-Derived Nitrogen-Doped Carbon Nanofiber Network: A Facile Template for Decoration of Ultrathin Nickel-Cobalt Layered Double Hydroxide Nanosheets as High-Performance Asymmetric Supercapacitor Electrode.

PubMed

Lai, Feili; Miao, Yue-E; Zuo, Lizeng; Lu, Hengyi; Huang, Yunpeng; Liu, Tianxi

2016-06-01

The development of biomass-based energy storage devices is an emerging trend to reduce the ever-increasing consumption of non-renewable resources. Here, nitrogen-doped carbonized bacterial cellulose (CBC-N) nanofibers are obtained by one-step carbonization of polyaniline coated bacterial cellulose (BC) nanofibers, which not only display excellent capacitive performance as the supercapacitor electrode, but also act as 3D bio-template for further deposition of ultrathin nickel-cobalt layered double hydroxide (Ni-Co LDH) nanosheets. The as-obtained CBC-N@LDH composite electrodes exhibit significantly enhanced specific capacitance (1949.5 F g(-1) at a discharge current density of 1 A g(-1) , based on active materials), high capacitance retention of 54.7% even at a high discharge current density of 10 A g(-1) and excellent cycling stability of 74.4% retention after 5000 cycles. Furthermore, asymmetric supercapacitors (ASCs) are constructed using CBC-N@LDH composites as positive electrode materials and CBC-N nanofibers as negative electrode materials. By virtue of the intrinsic pseudocapacitive characteristics of CBC-N@LDH composites and 3D nitrogen-doped carbon nanofiber networks, the developed ASC exhibits high energy density of 36.3 Wh kg(-1) at the power density of 800.2 W kg(-1) . Therefore, this work presents a novel protocol for the large-scale production of biomass-derived high-performance electrode materials in practical supercapacitor applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High-performance aqueous asymmetric supercapacitor based on K0.3WO3 nanorods and nitrogen-doped porous carbon

NASA Astrophysics Data System (ADS)

Ma, Guofu; Zhang, Zhiguo; Sun, Kanjun; Feng, Enke; Peng, Hui; Zhou, Xiaozhong; Lei, Ziqiang

2016-10-01

A novel asymmetric supercapacitor device for energy storage is fabricated using K0.3WO3 nanorods as negative electrode and nitrogen-doped porous carbon (CBC-1) based on agricultural wastes corn bract as positive electrode. The K0.3WO3 nanorods are composed of some thinner needle-shaped nanorods which are parallel to each other, and the CBC-1 reveals rough surface of coral-like frameworks with abundant nanopores. The structures can provide high surface area, low diffusion paths and intercalation/de-intercalation of electrolyte ions between the electrode/electrolyte interfaces. Thus, the asymmetric supercapacitor exhibits high energy density about 26.3 Wh kg-1 at power density of 404.2 W kg-1 in the wide voltage region of 0-1.6 V, as well as a good electrochemical stability (80% capacitance retention after 1000 cycles). Such outstanding electrochemical behaviors imply the CBC-1//K0.3WO3 asymmetric supercapacitor is a promising practical energy-storage system.

A High Performance COTS Based Computer Architecture

NASA Astrophysics Data System (ADS)

Patte, Mathieu; Grimoldi, Raoul; Trautner, Roland

2014-08-01

Using Commercial Off The Shelf (COTS) electronic components for space applications is a long standing idea. Indeed the difference in processing performance and energy efficiency between radiation hardened components and COTS components is so important that COTS components are very attractive for use in mass and power constrained systems. However using COTS components in space is not straightforward as one must account with the effects of the space environment on the COTS components behavior. In the frame of the ESA funded activity called High Performance COTS Based Computer, Airbus Defense and Space and its subcontractor OHB CGS have developed and prototyped a versatile COTS based architecture for high performance processing. The rest of the paper is organized as follows: in a first section we will start by recapitulating the interests and constraints of using COTS components for space applications; then we will briefly describe existing fault mitigation architectures and present our solution for fault mitigation based on a component called the SmartIO; in the last part of the paper we will describe the prototyping activities executed during the HiP CBC project.

Reducing the number of templates for aligned-spin compact binary coalescence gravitational wave searches using metric-agnostic template nudging

NASA Astrophysics Data System (ADS)

Indik, Nathaniel; Fehrmann, Henning; Harke, Franz; Krishnan, Badri; Nielsen, Alex B.

2018-06-01

Efficient multidimensional template placement is crucial in computationally intensive matched-filtering searches for gravitational waves (GWs). Here, we implement the neighboring cell algorithm (NCA) to improve the detection volume of an existing compact binary coalescence (CBC) template bank. This algorithm has already been successfully applied for a binary millisecond pulsar search in data from the Fermi satellite. It repositions templates from overdense regions to underdense regions and reduces the number of templates that would have been required by a stochastic method to achieve the same detection volume. Our method is readily generalizable to other CBC parameter spaces. Here we apply this method to the aligned-single-spin neutron star-black hole binary coalescence inspiral-merger-ringdown gravitational wave parameter space. We show that the template nudging algorithm can attain the equivalent effectualness of the stochastic method with 12% fewer templates.

Brayton Power Conversion System Study to Advance Technology Readiness for Nuclear Electric Propulsion

NASA Technical Reports Server (NTRS)

Allen, Bog; Delventhal, Rex; Frye, Patrick

2004-01-01

Recently, there has been significant interest within the aerospace community to develop space based nuclear power conversion technologies especially for exploring the outer planets of our solar system where the solar energy density is very low. To investigate these technologies NASA awarded several contracts under Project Prometheus, the Nuclear Systems Program. The studies described in this paper were performed under one of those contracts, which was to investigate the use of a nuclear power conversion system based on the closed Brayton cycle (CBC).The investigation performed included BPCS (Brayton Power Conversion System) trade studies to minimize system weight and radiator area and advance the state of the art of BPCS technology. The primary requirements for studies were a power level of 100 kWe (to the PPU), a low overall power system mass and a lifetime of 15 years (10 years full power). For the radiation environment, the system was to be capable of operation in the generic space environment and withstand the extreme environments surrounding Jupiter. The studies defined a BPCS design traceable to NEP (Nuclear Electric Propulsion) requirements and suitable for future missions with a sound technology plan for technology readiness level (TRL) advancement identified. The studies assumed a turbine inlet temperature approx. 100 C above the current the state of the art capabilities with materials issues and related development tasks identified. Analyses and evaluations of six different HRS (heat rejection system) designs and three primary power management and distribution (PMAD) configurations will be discussed in the paper.

Power systems for future missions

NASA Technical Reports Server (NTRS)

Gill, S. P.; Frye, P. E.; Littman, Franklin D.; Meisl, C. J.

1994-01-01

A comprehensive scenario of future missions was developed and applicability of different power technologies to these missions was assessed. Detailed technology development roadmaps for selected power technologies were generated. A simple methodology to evaluate economic benefits of current and future power system technologies by comparing Life Cycle Costs of potential missions was developed. The methodology was demonstrated by comparing Life Cycle Costs for different implementation strategies of DIPS/CBC technology to a selected set of missions.

The ATP-binding cassette transporter Cbc (choline/betaine/carnitine) recruits multiple substrate-binding proteins with strong specificity for distinct quaternary ammonium compounds

PubMed Central

Chen, Chiliang; Malek, Adel A.; Wargo, Matthew J.; Hogan, Deborah A.; Beattie, Gwyn A.

2017-01-01

Summary We identified a choline, betaine and carnitine transporter, designated Cbc, from Pseudomonas syringae and Pseudomonas aeruginosa that is unusual among members of the ATP-binding cassette (ABC) transporter family in its use of multiple periplasmic substrate-binding proteins (SBPs) that are highly specific for their substrates. The SBP encoded by the cbcXWV operon, CbcX, binds choline with a high affinity (Km, 2.6 μM) and, although it also binds betaine (Km, 24.2 μM), CbcXWV-mediated betaine uptake did not occur in the presence of choline. The CbcX orthologue ChoX from Sinorhizobium meliloti was similar to CbcX in these binding properties. The core transporter CbcWV also interacts with the carnitine-specific SBP CaiX (Km, 24 μM) and the betaine-specific SBP BetX (Km, 0.6 μM). Unlike most ABC transporter loci, caiX, betX and cbcXWV are separated in the genome. CaiX-mediated carnitine uptake was reduced by CbcX and BetX only when they were bound by their individual ligands, providing the first in vivo evidence for a higher affinity for ligand-bound than ligand-free SBPs by an ABC transporter. These studies demonstrate not only that the Cbc transporter serves as a useful model for exploring ABC transporter component interactions, but also that the orphan SBP genes common to bacterial genomes can encode functional SBPs. PMID:19919675

The ATP-binding cassette transporter Cbc (choline/betaine/carnitine) recruits multiple substrate-binding proteins with strong specificity for distinct quaternary ammonium compounds.

PubMed

Chen, Chiliang; Malek, Adel A; Wargo, Matthew J; Hogan, Deborah A; Beattie, Gwyn A

2010-01-01

We identified a choline, betaine and carnitine transporter, designated Cbc, from Pseudomonas syringae and Pseudomonas aeruginosa that is unusual among members of the ATP-binding cassette (ABC) transporter family in its use of multiple periplasmic substrate-binding proteins (SBPs) that are highly specific for their substrates. The SBP encoded by the cbcXWV operon, CbcX, binds choline with a high affinity (K(m), 2.6 microM) and, although it also binds betaine (K(m), 24.2 microM), CbcXWV-mediated betaine uptake did not occur in the presence of choline. The CbcX orthologue ChoX from Sinorhizobium meliloti was similar to CbcX in these binding properties. The core transporter CbcWV also interacts with the carnitine-specific SBP CaiX (K(m), 24 microM) and the betaine-specific SBP BetX (K(m), 0.6 microM). Unlike most ABC transporter loci, caiX, betX and cbcXWV are separated in the genome. CaiX-mediated carnitine uptake was reduced by CbcX and BetX only when they were bound by their individual ligands, providing the first in vivo evidence for a higher affinity for ligand-bound than ligand-free SBPs by an ABC transporter. These studies demonstrate not only that the Cbc transporter serves as a useful model for exploring ABC transporter component interactions, but also that the orphan SBP genes common to bacterial genomes can encode functional SBPs.

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

PubMed Central

Pabis, Marta; Neufeld, Noa; Steiner, Michaela C.; Bojic, Teodora; Shav-Tal, Yaron; Neugebauer, Karla M.

2013-01-01

The nuclear cap-binding complex (CBC) binds to the 7-methyl guanosine cap present on every RNA polymerase II transcript. CBC has been implicated in many aspects of RNA biogenesis; in addition to roles in miRNA biogenesis, nonsense-mediated decay, 3′-end formation, and snRNA export from the nucleus, CBC promotes pre-mRNA splicing. An unresolved question is how CBC participates in splicing. To investigate CBC’s role in splicing, we used mass spectrometry to identify proteins that copurify with mammalian CBC. Numerous components of spliceosomal snRNPs were specifically detected. Among these, three U4/U6·U5 snRNP proteins (hBrr2, hPrp4, and hPrp31) copurified with CBC in an RNA-independent fashion, suggesting that a significant fraction of CBC forms a complex with the U4/U6·U5 snRNP and that the activity of CBC might be associated with snRNP recruitment to pre-mRNA. To test this possibility, CBC was depleted from HeLa cells by RNAi. Chromatin immunoprecipitation and live-cell imaging assays revealed decreased cotranscriptional accumulation of U4/U6·U5 snRNPs on active transcription units, consistent with a requirement for CBC in cotranscriptional spliceosome assembly. Surprisingly, recruitment of U1 and U2 snRNPs was also affected, indicating that RNA-mediated interactions between CBC and snRNPs contribute to splicing. On the other hand, CBC depletion did not impair snRNP biogenesis, ruling out the possibility that decreased snRNP recruitment was due to changes in nuclear snRNP concentration. Taken together, the data support a model whereby CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly. PMID:23793891

Multicollision attack on CBC-MAC, EMAC, and XCBC-MAC of AES-128 algorithm

NASA Astrophysics Data System (ADS)

Brolin Sihite, Alfonso; Hayat Susanti, Bety

2017-10-01

A Message Authentication Codes (MAC) can be constructed based on a block cipher algorithm. CBC-MAC, EMAC, and XCBC-MAC constructions are some of MAC schemes that used in the hash function. In this paper, we do multicollision attack on CBC-MAC, EMAC, and XCBC-MAC construction which uses AES-128 block cipher algorithm as basic construction. The method of multicollision attack utilizes the concept of existential forgery on CBC-MAC. The results show that the multicollision can be obtained easily in CBC-MAC, EMAC, and XCBC-MAC construction.

The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters.

PubMed

Li, Tianlu; De Clercq, Nikki; Medina, Daniel A; Garre, Elena; Sunnerhagen, Per; Pérez-Ortín, José E; Alepuz, Paula

2016-02-01

The highly conserved Saccharomyces cerevisiae cap-binding protein Cbc1/Sto1 binds mRNA co-transcriptionally and acts as a key coordinator of mRNA fate. Recently, Cbc1 has also been implicated in transcription elongation and pre-initiation complex (PIC) formation. Previously, we described Cbc1 to be required for cell growth under osmotic stress and to mediate osmostress-induced translation reprogramming. Here, we observe delayed global transcription kinetics in cbc1Δ during osmotic stress that correlates with delayed recruitment of TBP and RNA polymerase II to osmo-induced promoters. Interestingly, we detect an interaction between Cbc1 and the MAPK Hog1, which controls most gene expression changes during osmostress, and observe that deletion of CBC1 delays the accumulation of the activator complex Hot1-Hog1 at osmostress promoters. Additionally, CBC1 deletion specifically reduces transcription rates of highly transcribed genes under non-stress conditions, such as ribosomal protein (RP) genes, while having low impact on transcription of weakly expressed genes. For RP genes, we show that recruitment of the specific activator Rap1, and subsequently TBP, to promoters is Cbc1-dependent. Altogether, our results indicate that binding of Cbc1 to the capped mRNAs is necessary for the accumulation of specific activators as well as PIC components at the promoters of genes whose expression requires high and rapid transcription. Copyright © 2016 Elsevier B.V. All rights reserved.

High Temperature Fusion Reactor Cooling Using Brayton Cycle Based Partial Energy Conversion

NASA Technical Reports Server (NTRS)

Juhasz, Albert J.; Sawicki, Jerzy T.

2003-01-01

For some future space power systems using high temperature nuclear heat sources most of the output energy will be used in other than electrical form, and only a fraction of the total thermal energy generated will need to be converted to electrical work. The paper describes the conceptual design of such a partial energy conversion system, consisting of a high temperature fusion reactor operating in series with a high temperature radiator and in parallel with dual closed cycle gas turbine (CCGT) power systems, also referred to as closed Brayton cycle (CBC) systems, which are supplied with a fraction of the reactor thermal energy for conversion to electric power. Most of the fusion reactor's output is in the form of charged plasma which is expanded through a magnetic nozzle of the interplanetary propulsion system. Reactor heat energy is ducted to the high temperature series radiator utilizing the electric power generated to drive a helium gas circulation fan. In addition to discussing the thermodynamic aspects of the system design the authors include a brief overview of the gas turbine and fan rotor-dynamics and proposed bearing support technology along with performance characteristics of the three phase AC electric power generator and fan drive motor.

High Temperature Fusion Reactor Cooling Using Brayton Cycle Based Partial Energy Conversion

NASA Astrophysics Data System (ADS)

Juhasz, Albert J.; Sawicki, Jerzy T.

2004-02-01

For some future space power systems using high temperature nuclear heat sources most of the output energy will be used in other than electrical form, and only a fraction of the total thermal energy generated will need to be converted to electrical work. The paper describes the conceptual design of such a ``partial energy conversion'' system, consisting of a high temperature fusion reactor operating in series with a high temperature radiator and in parallel with dual closed cycle gas turbine (CCGT) power systems, also referred to as closed Brayton cycle (CBC) systems, which are supplied with a fraction of the reactor thermal energy for conversion to electric power. Most of the fusion reactor's output is in the form of charged plasma which is expanded through a magnetic nozzle of the interplanetary propulsion system. Reactor heat energy is ducted to the high temperature series radiator utilizing the electric power generated to drive a helium gas circulation fan. In addition to discussing the thermodynamic aspects of the system design the authors include a brief overview of the gas turbine and fan rotor-dynamics and proposed bearing support technology along with performance characteristics of the three phase AC electric power generator and fan drive motor.

Practical laboratory-based clinical decision tools and associations with short-term bleeding and mortality outcomes.

PubMed

Graves, Kevin G; Muhlestein, Joseph B; Lappé, Donald L; McCubrey, Raymond O; May, Heidi T; Knight, Stacey; Le, Viet T; Bair, Tami L; Anderson, Jeffrey L; Horne, Benjamin D

2018-07-01

The red cell distribution width (RDW) predicts mortality in numerous populations. The Intermountain Risk Scores (IMRS) predict patient outcomes using laboratory measurements including RDW. Whether the RDW or IMRS predicts in-hospital outcomes is unknown. The predictive abilities of RDW and two IMRS formulations (the complete blood count [CBC] risk score [CBC-RS] or full IMRS using CBC plus the basic metabolic profile) were studied among percutaneous coronary intervention patients at Intermountain (males: N = 6007, females: N = 2165). Primary endpoints were a composite bleeding outcome and in-hospital mortality. IMRS predicted the composite bleeding endpoint (females: χ 2  = 47.1, odds ratio [OR] = 1.13 per +1 score, p < 0.001; males: χ 2  = 108.7, OR = 1.13 per +1 score, p < 0.001) more strongly than RDW (females: χ 2  = 1.6, OR = 1.04 per +1%, p = 0.20; males: χ 2  = 11.2, OR = 1.09 per +1%, p < 0.001). For in-hospital mortality, RDW was predictive in females (χ 2  = 4.3, OR = 1.13 per +1%, p = 0.037) and males (χ 2  = 4.4, OR = 1.11 per +1%, p = 0.037), but IMRS was profoundly more predictive (females: χ 2  = 35.5, OR = 1.36 per +1 score, p < 0.001; males: χ 2  = 72.9, OR = 1.40 per+1 score, p < 0.001). CBC-RS was more predictive than RDW but not as powerful as IMRS. The IMRS, the CBC-RS, and RDW predict in-hospital outcomes. Risk score-directed personalization of in-hospital clinical care should be studied. Copyright © 2018 Elsevier B.V. All rights reserved.

Review of methods for handling confounding by cluster and informative cluster size in clustered data

PubMed Central

Seaman, Shaun; Pavlou, Menelaos; Copas, Andrew

2014-01-01

Clustered data are common in medical research. Typically, one is interested in a regression model for the association between an outcome and covariates. Two complications that can arise when analysing clustered data are informative cluster size (ICS) and confounding by cluster (CBC). ICS and CBC mean that the outcome of a member given its covariates is associated with, respectively, the number of members in the cluster and the covariate values of other members in the cluster. Standard generalised linear mixed models for cluster-specific inference and standard generalised estimating equations for population-average inference assume, in general, the absence of ICS and CBC. Modifications of these approaches have been proposed to account for CBC or ICS. This article is a review of these methods. We express their assumptions in a common format, thus providing greater clarity about the assumptions that methods proposed for handling CBC make about ICS and vice versa, and about when different methods can be used in practice. We report relative efficiencies of methods where available, describe how methods are related, identify a previously unreported equivalence between two key methods, and propose some simple additional methods. Unnecessarily using a method that allows for ICS/CBC has an efficiency cost when ICS and CBC are absent. We review tools for identifying ICS/CBC. A strategy for analysis when CBC and ICS are suspected is demonstrated by examining the association between socio-economic deprivation and preterm neonatal death in Scotland. PMID:25087978

Resistance of Pseudomonas to Quaternary Ammonium Compounds. I. Growth in Benzalkonium Chloride Solution

PubMed Central

Adair, Frank W.; Geftic, Sam G.; Gelzer, Justus

1969-01-01

Resistant cells of Pseudomonas aeruginosa and a waterborne Pseudomonas sp. (strain Z-R) were able to multiply in nitrogen-free minimal salts solution containing various concentrations of commercially prepared, ammonium acetate-buffered benzalkonium chloride (CBC), a potent antimicrobial agent. As the CBC concentration increased, growth increased until a point was reached at which the extent of growth leveled off or was completely depressed. Minimal salts solutions of pure benzalkonium chloride (PBC) containing no ammonium acetate did not support bacterial growth. When ammonium acetate was added to PBC solutions in the same concentrations found in CBC solutions, growth patterns developed that were comparable to those found with CBC. Likewise, (NH4)2SO4 added to PBC solutions supported growth of both organisms. P. aeruginosa was initially resistant to CBC levels of 0.02% and it was adapted to tolerate levels as high as 0.36%. Strain Z-R was naturally resistant to 0.4% CBC. Since ammonium acetate, carried over by the CBC used in drug formulations and disinfectant solutions, has the potential to support the growth of resistant bacteria and thus make possible the risk of serious infection, it is suggested that regulations allowing the presence of ammonium acetate in CBC solution be reconsidered. PMID:4984761

Design and Off-design Performance of 100 Kwe-class Brayton Power Conversion Systems

NASA Technical Reports Server (NTRS)

Johnson, Paul K.; Mason, Lee S.

2005-01-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30, 45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50% of nominal), and circulating a percentage (up to 20%) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

Searching for gravitational-waves from compact binary coalescences while dealing with challenges of real data and simulated waveforms

NASA Astrophysics Data System (ADS)

Dayanga, Waduthanthree Thilina

Albert Einstein's general theory of relativity predicts the existence of gravitational waves (GWs). Direct detection of GWs will provide enormous amount of new information about physics, astronomy and cosmology. Scientists around the world are currently working towards the first direct detection of GWs. The global network of ground-based GW detectors are currently preparing for their first advanced detector Science runs. In this thesis we focus on detection of GWs from compact binary coalescence (CBC) systems. Ability to accurately model CBC GW waveforms makes them the most promising source for the first direct detection of GWs. In this thesis we try to address several challenges associated with detecting CBC signals buried in ground-based GW detector data for past and future searches. Data analysis techniques we employ to detect GW signals assume detector noise is Gaussian and stationary. However, in reality, detector data is neither Gaussian nor stationary. To estimate the performance loss due to these features, we compare the efficiencies of detecting CBC signals in simulated Gaussian and real data. Additionally, we also demonstrate the effectiveness of multi-detector signal based consistency tests such ad null-stream. Despite, non-Gaussian and non-stationary features of real detector data, with effective data quality studies and signal-based vetoes we can approach the performance of Gaussian and stationary data. As we are moving towards advanced detector era, it is important to be prepared for future CBC searches. In this thesis we investigate the performances of non-spinning binary black hole (BBH) searches in simulated Gaussian using advanced detector noise curves predicted for 2015--2016. In the same study, we analyze the GW detection probabilities of latest pN-NR hybrid waveforms submitted to second version of Numerical Injection Analysis (NINJA-2) project. The main motivation for this study is to understand the ability to detect realistic BBH signals of currently available template waveforms in LIGO Algorithms Libraries (LAL) such as EOBNR waveform family. Results of the analysis demonstrates, although the detection efficiency is least affected, parameter estimation can be challenging in future searches. Many authors suggested and demonstrated coherent searches are the most sensitive in detecting GW signals using network of multiple detectors. Owing to computational expenses in recent Science data searches of LIGO and Virgo we did not employ coherent search methods. In this thesis we demonstrate how to employ coherent searches for current CBC searches in computational feasible way. As a solution, we thoroughly investigate many aspects of coherent searches using a all-sky blind hierarchical coherent pipeline. Most importantly we presents some powerful insights extracted by running coherent hierarchical pipeline on LIGO and Virgo data. This also includes the challenges we need to address before moving to all-sky all-time fully coherent searches. Estimating GW background play critical role in data analysis. We are still exploring the best way to estimate background of a CBC GW search when one or more signal present in data. In this thesis we try to address this to certain extend through NINJA-2 mock data challenge. However, due to limitations of methods and computer power, for triple coincident GW candidates we only consider loudest two interferometers for background estimation purposes.

Molecular and Biochemical Characterization of a Cathepsin B-Like Protease Family Unique to Trypanosoma congolense▿ †

PubMed Central

Mendoza-Palomares, Carlos; Biteau, Nicolas; Giroud, Christiane; Coustou, Virginie; Coetzer, Theresa; Authié, Edith; Boulangé, Alain; Baltz, Théo

2008-01-01

Cysteine proteases have been shown to be essential virulence factors and drug targets in trypanosomatids and an attractive antidisease vaccine candidate for Trypanosoma congolense. Here, we describe an important amplification of genes encoding cathepsin B-like proteases unique to T. congolense. More than 13 different genes were identified, whereas only one or two highly homologous genes have been identified in other trypanosomatids. These proteases grouped into three evolutionary clusters: TcoCBc1 to TcoCBc5 and TcoCBc6, which possess the classical catalytic triad (Cys, His, and Asn), and TcoCBs7 to TcoCBs13, which contains an unusual catalytic site (Ser, Xaa, and Asn). Expression profiles showed that members of the TcoCBc1 to TcoCBc5 and the TcoCBs7 to TcoCBs13 groups are expressed mainly in bloodstream forms and localize in the lysosomal compartment. The expression of recombinant representatives of each group (TcoCB1, TcoCB6, and TcoCB12) as proenzymes showed that TcoCBc1 and TcoCBc6 are able to autocatalyze their maturation 21 and 31 residues, respectively, upstream of the predicted start of the catalytic domain. Both displayed a carboxydipeptidase function, while only TcoCBc1 behaved as an endopeptidase. TcoCBc1 exhibited biochemical differences regarding inhibitor sensitivity compared to that of other cathepsin B-like proteases. Recombinant pro-TcoCBs12 did not automature in vitro, and the pepsin-matured enzyme was inactive in tests with cathepsin B fluorogenic substrates. In vivo inhibition studies using CA074Me (a cell-permeable cathepsin B-specific inhibitor) demonstrated that TcoCB are involved in lysosomal protein degradation essential for survival in bloodstream form. Furthermore, TcoCBc1 elicited an important immune response in experimentally infected cattle. We propose this family of proteins as a potential therapeutic target and as a plausible antigen for T. congolense diagnosis. PMID:18281598

Complete blood count risk score and its components, including RDW, are associated with mortality in the JUPITER trial.

PubMed

Horne, Benjamin D; Anderson, Jeffrey L; Muhlestein, Joseph B; Ridker, Paul M; Paynter, Nina P

2015-04-01

Previously, we showed that sex-specific complete blood count (CBC) risk scores strongly predicted risk of all-cause mortality in multiple sets of general medical patients. This study evaluated the CBC risk score in an independent, well-studied international primary risk population of lower-risk individuals initially free from cardiovascular (CV) disease. Observational secondary analysis of a randomized trial population. The previously derived and validated CBC score was evaluated for association with all-cause mortality among CV disease-free females (n = 6568) and males (n = 10,629) enrolled for up to 5 years in the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Associations of the CBC score with CV mortality and with major CV disease were also tested. The CBC score predicted all-cause mortality, with univariable hazard ratio (HR) 4.83 (95% CI 3.70-6.31) for the third CBC score tertile vs. the first tertile, and HR 2.31 (CI 1.75-3.05) for the second tertile (p trend < 0.001). The CBC score retained significance after adjustment: HR 1.97 (CI 1.46-2.67) and 1.51 (CI 1.13-2.00) for tertiles 3 and 2 vs. 1, respectively (p trend < 0.001). The CBC score also predicted CV mortality (p trend = 0.025) and the primary JUPITER endpoint (p trend = 0.015). c-statistics for mortality were 0.729 among all, and 0.722 and 0.750 for females and males, respectively. The CBC risk score was strongly associated with all-cause mortality among JUPITER trial participants and had good discrimination. It also predicted CV-specific outcomes. This CBC score may be useful in identifying cardiac disease-free individuals at increased risk of mortality. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

The effect of cannabichromene on adult neural stem/progenitor cells.

PubMed

Shinjyo, Noriko; Di Marzo, Vincenzo

2013-11-01

Apart from the psychotropic compound Δ(9)-tetrahydrocannabinol (THC), evidence suggests that other non-psychotropic phytocannabinoids are also of potential clinical use. This study aimed at elucidating the effect of major non-THC phytocannabinoids on the fate of adult neural stem progenitor cells (NSPCs), which are an essential component of brain function in health as well as in pathology. We tested three compounds: cannabidiol, cannabigerol, and cannabichromene (CBC), and found that CBC has a positive effect on the viability of mouse NSPCs during differentiation in vitro. The expression of NSPC and astrocyte markers nestin and Glial fibrillary acidic protein (GFAP), respectively, was up- and down-regulated, respectively. CBC stimulated ERK1/2 phosphorylation; however, this effect had a slower onset in comparison to typical MAPK stimulation. A MEK inhibitor, U0126, antagonized the up-regulation of nestin but not the down-regulation of GFAP. Based on a previous report, we studied the potential involvement of the adenosine A1 receptor in the effect of CBC on these cells and found that the selective adenosine A1 receptor antagonist, DPCPX, counteracted both ERK1/2 phosphorylation and up-regulation of nestin by CBC, indicating that also adenosine is involved in these effects of CBC, but possibly not in CBC inhibitory effect on GFAP expression. Next, we measured ATP levels as an equilibrium marker of adenosine and found higher ATP levels during differentiation of NSPCs in the presence of CBC. Taken together, our results suggest that CBC raises the viability of NSPCs while inhibiting their differentiation into astroglia, possibly through up-regulation of ATP and adenosine signalling. Copyright © 2013 Elsevier Ltd. All rights reserved.

Predictors associated with MRI surveillance screening in women with a personal history of unilateral breast cancer but without a genetic predisposition for future contralateral breast cancer.

PubMed

Hegde, John V; Wang, Xiaoyan; Attai, Deanna J; DiNome, Maggie L; Kusske, Amy; Hoyt, Anne C; Hurvitz, Sara A; Weidhaas, Joanne B; Steinberg, Michael L; McCloskey, Susan A

2017-11-01

For women with a personal history of breast cancer (PHBC), no validated mechanisms exist to calculate future contralateral breast cancer (CBC) risk. The Manchester risk stratification guidelines were developed to evaluate CBC risk in women with a PHBC, primarily for surgical decision making. This tool may be informative for the use of MRI screening, as CBC risk is an assumed consideration for high-risk surveillance. Three hundred twenty-two women with a PHBC were treated with unilateral surgery within our multidisciplinary breast clinic. We calculated lifetime CBC risk using the Manchester tool, which incorporates age at diagnosis, family history, genetic mutation status, estrogen receptor positivity, and endocrine therapy use. Univariate and multivariate logistic regression analyses (UVA/MVA) were performed, evaluating whether CBC risk predicted MRI surveillance. For women with invasive disease undergoing MRI surveillance, 66% had low, 23% above-average, and 11% moderate/high risk for CBC. On MVA, previous mammography-occult breast cancer [odds ratio (OR) 18.95, p < 0.0001], endocrine therapy use (OR 3.89, p = 0.009), dense breast tissue (OR 3.69, p = 0.0007), mastectomy versus lumpectomy (OR 3.12, p = 0.0041), and CBC risk (OR 3.17 for every 10% increase, p = 0.0002) were associated with MRI surveillance. No pathologic factors increasing ipsilateral breast cancer recurrence were significant on MVA. Although CBC risk predicted MRI surveillance, 89% with invasive disease undergoing MRI had <20% calculated CBC risk. Concerns related to future breast cancer detectability (dense breasts and/or previous mammography-occult disease) predominate decision making. Pathologic factors important for determining ipsilateral recurrence risk, aside from age, were not associated with MRI surveillance.

A taxonomy for community-based care programs focused on HIV/AIDS prevention, treatment, and care in resource-poor settings.

PubMed

Rachlis, Beth; Sodhi, Sumeet; Burciul, Barry; Orbinski, James; Cheng, Amy H Y; Cole, Donald

2013-04-16

Community-based care (CBC) can increase access to key services for people affected by HIV/AIDS through the mobilization of community interests and resources and their integration with formal health structures. Yet, the lack of a systematic framework for analysis of CBC focused on HIV/AIDS impedes our ability to understand and study CBC programs. We sought to develop taxonomy of CBC programs focused on HIV/AIDS in resource-limited settings in an effort to understand their key characteristics, uncover any gaps in programming, and highlight the potential roles they play. Our review aimed to systematically identify key CBC programs focused on HIV/AIDS in resource-limited settings. We used both bibliographic database searches (Medline, CINAHL, and EMBASE) for peer-reviewed literature and internet-based searches for gray literature. Our search terms were 'HIV' or 'AIDS' and 'community-based care' or 'CBC'. Two co-authors developed a descriptive taxonomy through an iterative, inductive process using the retrieved program information. We identified 21 CBC programs useful for developing taxonomy. Extensive variation was observed within each of the nine categories identified: region, vision, characteristics of target populations, program scope, program operations, funding models, human resources, sustainability, and monitoring and evaluation strategies. While additional research may still be needed to identify the conditions that lead to overall program success, our findings can help to inform our understanding of the various aspects of CBC programs and inform potential logic models for CBC programming in the context of HIV/AIDS in resource-limited settings. Importantly, the findings of the present study can be used to develop sustainable HIV/AIDS-service delivery programs in regions with health resource shortages.

Performance Analyses of 38 kWe Turbo-Machine Unit for Space Reactor Power Systems

NASA Astrophysics Data System (ADS)

Gallo, Bruno M.; El-Genk, Mohamed S.

2008-01-01

This paper developed a design and investigated the performance of 38 kWe turbo-machine unit for space nuclear reactor power systems with Closed Brayton Cycle (CBC) energy conversion. The compressor and turbine of this unit are scaled versions of the NASA's BRU developed in the sixties and seventies. The performance results of turbo-machine unit are calculated for rotational speed up to 45 krpm, variable reactor thermal power and system pressure, and fixed turbine and compressor inlet temperatures of 1144 K and 400 K. The analyses used a detailed turbo-machine model developed at the University of New Mexico that accounts for the various energy losses in the compressor and turbine and the effect of compressibility of the He-Xe (40 mole/g) working fluid with increased flow rate. The model also accounts for the changes in the physical and transport properties of the working fluid with temperature and pressure. Results show that a unit efficiency of 24.5% is achievable at rotation speed of 45 krpm and system pressure of 0.75 MPa, assuming shaft and electrical generator efficiencies of 86.7% and 90%. The corresponding net electric power output of the unit is 38.5 kWe, the flow rate of the working fluid is 1.667 kg/s, the pressure ratio and polytropic efficiency for the compressor are 1.60 and 83.1%, and 1.51 and 88.3% for the turbine.

Coherent combining of high brightness tapered lasers in master oscillator power amplifier configuration

NASA Astrophysics Data System (ADS)

Albrodt, P.; Hanna, M.; Moron, F.; Decker, J.; Winterfeldt, M.; Blume, G.; Erbert, G.; Crump, P.; Georges, P.; Lucas-Leclin, G.

2018-02-01

Improved diode laser beam combining techniques are in strong demand for applications in material processing. Coherent beam combining (CBC) is the only combining approach that has the potential to maintain or even improve all laser properties, and thus has high potential for future systems. As part of our ongoing studies into CBC of diode lasers, we present recent progress in the coherent superposition of high-power single-pass tapered laser amplifiers. The amplifiers are seeded by a DFB laser at λ = 976 nm, where the seed is injected into a laterally single-mode ridge-waveguide input section. The phase pistons on each beam are actively controlled by varying the current in the ridge section of each amplifier, using a sequential hill-climbing algorithm, resulting in a combined beam with power fluctuations of below 1%. The currents into the tapered sections of the amplifiers are separately controlled, and remain constant. In contrast to our previous studies, we favour a limited number of individual high-power amplifiers, in order to preserve a high extracted power per emitter in a simple, low-loss coupling arrangement. Specifically, a multi-arm interferometer architecture with only three devices is used, constructed using 6 mm-long tapered amplifiers, mounted junction up on C-mounts, to allow separate contact to single mode and amplifier sections. A maximum coherently combined power of 12.9 W is demonstrated in a nearly diffraction-limited beam, corresponding to a 65% combining efficiency, with power mainly limited by the intrinsic beam quality of the amplifiers. Further increased combined power is currently sought.

Novel adaptive fiber-optics collimator for coherent beam combination.

PubMed

Zhi, Dong; Ma, Pengfei; Ma, Yanxing; Wang, Xiaolin; Zhou, Pu; Si, Lei

2014-12-15

In this manuscript, we experimentally validate a novel design of adaptive fiber-optics collimator (AFOC), which utilizes two levers to enlarge the movable range of the fiber end cap. The enlargement of the range makes the new AFOC possible to compensate the end-cap/tilt aberration in fiber laser beam combining system. The new AFOC based on flexible hinges and levers was fabricated and the performance of the new AFOC was tested carefully, including its control range, frequency response and control accuracy. Coherent beam combination (CBC) of two 5-W fiber amplifiers array with simultaneously end-cap/tilt control and phase-locking control was implemented successfully with the novel AFOC. Experimental results show that the average normalized power in the bucket (PIB) value increases from 0.311 to 0.934 with active phasing and tilt aberration compensation simultaneously, and with both controls on, the fringe contrast improves to more than 82% from 0% for the case with both control off. This work presents a promising structure for tilt aberration control in high power CBC system.

Does Challenge by Choice Increase Participation?

ERIC Educational Resources Information Center

Chase, Daniel L.

2015-01-01

Challenge by choice (CBC) has been regarded as a foundational principle for challenge ropes course programs. Although CBC is widely accepted as the primary mechanism for facilitating intended ropes course outcomes, especially a participant's involvement, until recently it had remained an untested assumption. This study explored the role of CBC as…

Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries.

PubMed

Mezencev, Roman; Švajdler, Marián

2017-05-01

Women diagnosed with breast cancer display higher propensity to develop second primary cancer in the contralateral breast (CBC). Identification of patients with increased risk of CBC and understanding relationships between hormone receptor (HR) statuses of the first and second breast cancers is desirable for endocrine-based prevention strategies. Using 1992-2012 data from 13 SEER registries, the risk of developing CBC was determined as ratio of observed and expected second breast cancers (SIR). Association between HR statuses was examined by exploratory data analysis and multivariable logistic regression. Women with ER-positive and ER-negative breast cancers have increased risk of developing CBC with SIR values 2.09 (CI 95 = 1.97-2.21) and 2.40 (CI 95 = 2.18-2.63), respectively. ER statuses of the CBC are moderately positively associated. In metachronous CBC, most cases with ER-positive first cancers had ER-positive second breast cancers (81.6 %; CI 95 = 80.2-82.9 %); however, considerable proportion of cases with ER-negative first cancers had ER-positive second cancers (48.8 %; CI 95 = 46.2-51.4 %). Some women with ER-negative breast cancers may benefit from endocrine-based prevention of ER-positive CBC.

Analysis of the Nonlinear Characteristics of Microwave Power Heterojunction Bipolar Transistors and Optoelectronic Integrated Circuits.

NASA Astrophysics Data System (ADS)

Samelis, Apostolos

A physical basis for large-signal HBT modeling was established in terms of transit times using a Monte Carlo analysis of AlGaAs/GaAs and GaInP/GaAs designs. Static carriers located in the collector-subcollector interface were found to prohibit accurate evaluation of transit times from electron velocity profiles. These carriers also influence the bias dependence of device capacitances. Analytical parameter extraction techniques for DC, thermal and high frequency HBT parameters were developed and applied to HBT large-signal modeling. The "impedance block" conditioned optimization technique was introduced to facilitate parameter extraction. Physical analysis of HBTs by means of Volterra Series techniques showed that C_{bc } dominates nonlinear distortion in high gain amplifiers. Designs with that C_{bc }-V_{cb} characteristics i.e. p -n collector HBTs lead to more than 10 dB IP3 improvement over n-collector HBTs. Nonlinear current cancellation was found to improve intermodulation distortion. A Gummel -Poon-based HBT large-signal model incorporating self-heating effects was developed and applied to AlGaAs/GaAs HBTs. Maximum power drive was shown to occur using constant V _{be} father than I_ {b} bias. The device temperature of constant I_{b} biased HBTs decreases at increased rf-drive levels ensuring in this case safer device operation. A large-signal model incorporating "soft" -breakdown effects typical of InP/InGaAs HBTs was developed and found to model succesfully the power characteristics of OEICs built with them. The effective large-signal transimpedance of a cascode transimpedance preamplifier was evaluated using this model and found to degrade by 3dBOmega for a variation of P_{in} from -65 to -5 dBm. Self-bias of individual transistors was studied and found to be related to variations of the amplifier characteristics at higher rf-drive levels. The power characteristics of CE and CB AlGaAs/GaAs HBTs were investigated using an on -wafer source/load pull setup developed for this purpose. The load-pull power, intermodulation and efficiency contours of power CE HBTs are eccentric due to the feedback provided by C_{bc} between the input and output of the device. Concentric contours were found for P_{out} and PAE of CB HBTs.

Congruence in Parent-Teacher Communication: Implications for the Efficacy of CBC for Students with Behavioral Concerns

ERIC Educational Resources Information Center

Garbacz, S. Andrew; Sheridan, Susan M.; Koziol, Natalie A.; Kwon, Kyongboon; Holmes, Shannon R.

2015-01-01

The present study examined parent-teacher congruent communication within conjoint behavioral consultation (CBC). Specifically, the study purpose was to determine the extent to which congruence in parent-teacher communication (i.e., the degree to which parents and teachers view their communication in a similar fashion) moderated CBC's effects on…

A close-up view on ITS2 evolution and speciation - a case study in the Ulvophyceae (Chlorophyta, Viridiplantae)

PubMed Central

2011-01-01

Background The second Internal Transcriber Spacer (ITS2) is a fast evolving part of the nuclear-encoded rRNA operon located between the 5.8S and 28S rRNA genes. Based on crossing experiments it has been proposed that even a single Compensatory Base Change (CBC) in helices 2 and 3 of the ITS2 indicates sexual incompatibility and thus separates biological species. Taxa without any CBC in these ITS2 regions were designated as a 'CBC clade'. However, in depth comparative analyses of ITS2 secondary structures, ITS2 phylogeny, the origin of CBCs, and their relationship to biological species have rarely been performed. To gain 'close-up' insights into ITS2 evolution, (1) 86 sequences of ITS2 including secondary structures have been investigated in the green algal order Ulvales (Chlorophyta, Viridiplantae), (2) after recording all existing substitutions, CBCs and hemi-CBCs (hCBCs) were mapped upon the ITS2 phylogeny, rather than merely comparing ITS2 characters among pairs of taxa, and (3) the relation between CBCs, hCBCs, CBC clades, and the taxonomic level of organisms was investigated in detail. Results High sequence and length conservation allowed the generation of an ITS2 consensus secondary structure, and introduction of a novel numbering system of ITS2 nucleotides and base pairs. Alignments and analyses were based on this structural information, leading to the following results: (1) in the Ulvales, the presence of a CBC is not linked to any particular taxonomic level, (2) most CBC 'clades' sensu Coleman are paraphyletic, and should rather be termed CBC grades. (3) the phenetic approach of pairwise comparison of sequences can be misleading, and thus, CBCs/hCBCs must be investigated in their evolutionary context, including homoplasy events (4) CBCs and hCBCs in ITS2 helices evolved independently, and we found no evidence for a CBC that originated via a two-fold hCBC substitution. Conclusions Our case study revealed several discrepancies between ITS2 evolution in the Ulvales and generally accepted assumptions underlying ITS2 evolution as e.g. the CBC clade concept. Therefore, we developed a suite of methods providing a critical 'close-up' view into ITS2 evolution by directly tracing the evolutionary history of individual positions, and we caution against a non-critical use of the ITS2 CBC clade concept for species delimitation. PMID:21933414

Structural models of increasing complexity for icosahedral boron carbide with compositions throughout the single-phase region from first principles

NASA Astrophysics Data System (ADS)

Ektarawong, A.; Simak, S. I.; Alling, B.

2018-05-01

We perform first-principles calculations to investigate the phase stability of boron carbide, concentrating on the recently proposed alternative structural models composed not only of the regularly studied B11Cp (CBC) and B12(CBC), but also of B12(CBCB) and B12( B4 ). We find that a combination of the four structural motifs can result in low-energy electron precise configurations of boron carbide. Among several considered configurations within the composition range of B10.5C and B4C , we identify in addition to the regularly studied B11Cp (CBC) at the composition of B4C two low-energy configurations, resulting in a new view of the B-C convex hull. Those are [B12 (CBC)]0.67[B12(B4)] 0.33 and [B12 (CBC)]0.67[ B12 (CBCB)]0.33, corresponding to compositions of B10.5C and B6.67C , respectively. As a consequence, B12(CBC) at the composition of B6.5C , previously suggested in the literature as a stable configuration of boron carbide, is no longer part of the B -C convex hull. By inspecting the electronic density of states as well as the elastic moduli, we find that the alternative models of boron carbide can provide a reasonably good description for electronic and elastic properties of the material in comparison with the experiments, highlighting the importance of considering B12(CBCB) and B12( B4 ), together with the previously proposed B11Cp (CBC) and B12(CBC), as the crucial ingredients for modeling boron carbide with compositions throughout the single-phase region.

A taxonomy for community-based care programs focused on HIV/AIDS prevention, treatment, and care in resource-poor settings

PubMed Central

Rachlis, Beth; Sodhi, Sumeet; Burciul, Barry; Orbinski, James; Cheng, Amy H.Y.; Cole, Donald

2013-01-01

Community-based care (CBC) can increase access to key services for people affected by HIV/AIDS through the mobilization of community interests and resources and their integration with formal health structures. Yet, the lack of a systematic framework for analysis of CBC focused on HIV/AIDS impedes our ability to understand and study CBC programs. We sought to develop taxonomy of CBC programs focused on HIV/AIDS in resource-limited settings in an effort to understand their key characteristics, uncover any gaps in programming, and highlight the potential roles they play. Our review aimed to systematically identify key CBC programs focused on HIV/AIDS in resource-limited settings. We used both bibliographic database searches (Medline, CINAHL, and EMBASE) for peer-reviewed literature and internet-based searches for gray literature. Our search terms were ‘HIV’ or ‘AIDS’ and ‘community-based care’ or ‘CBC’. Two co-authors developed a descriptive taxonomy through an iterative, inductive process using the retrieved program information. We identified 21 CBC programs useful for developing taxonomy. Extensive variation was observed within each of the nine categories identified: region, vision, characteristics of target populations, program scope, program operations, funding models, human resources, sustainability, and monitoring and evaluation strategies. While additional research may still be needed to identify the conditions that lead to overall program success, our findings can help to inform our understanding of the various aspects of CBC programs and inform potential logic models for CBC programming in the context of HIV/AIDS in resource-limited settings. Importantly, the findings of the present study can be used to develop sustainable HIV/AIDS-service delivery programs in regions with health resource shortages. PMID:23594416

Design and Off-Design Performance of 100 kWe-Class Brayton Power Conversion Systems

NASA Technical Reports Server (NTRS)

Johnson, Paul K.; Mason, Lee S.

2005-01-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30, 45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), helium-xenon working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50 percent of nominal), and circulating a percentage (up to 20 percent) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

Design and Off-Design Performance of 100 kWe-Class Brayton Power Conversion Systems

NASA Astrophysics Data System (ADS)

Johnson, Paul K.; Mason, Lee S.

2005-02-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30,45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), helium-xenon working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50% of nominal), and circulating a percentage (up to 20%) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

Experimental demonstration of using divergence cost-function in SPGD algorithm for coherent beam combining with tip/tilt control.

PubMed

Geng, Chao; Luo, Wen; Tan, Yi; Liu, Hongmei; Mu, Jinbo; Li, Xinyang

2013-10-21

A novel approach of tip/tilt control by using divergence cost function in stochastic parallel gradient descent (SPGD) algorithm for coherent beam combining (CBC) is proposed and demonstrated experimentally in a seven-channel 2-W fiber amplifier array with both phase-locking and tip/tilt control, for the first time to our best knowledge. Compared with the conventional power-in-the-bucket (PIB) cost function for SPGD optimization, the tip/tilt control using divergence cost function ensures wider correction range, automatic switching control of program, and freedom of camera's intensity-saturation. Homemade piezoelectric-ring phase-modulator (PZT PM) and adaptive fiber-optics collimator (AFOC) are developed to correct piston- and tip/tilt-type aberrations, respectively. The PIB cost function is employed for phase-locking via maximization of SPGD optimization, while the divergence cost function is used for tip/tilt control via minimization. An average of 432-μrad of divergence metrics in open loop has decreased to 89-μrad when tip/tilt control implemented. In CBC, the power in the full width at half maximum (FWHM) of the main lobe increases by 32 times, and the phase residual error is less than λ/15.

Cognitive-behavioral intervention to promote smoking cessation for pregnant and postpartum inner city women

PubMed Central

Lee, Minsun; Wen, Kuang-Yi; Hui, Sui-kuen Azor; Roussi, Pagona; Hernandez, Enrique

2015-01-01

This study evaluated a theory-guided cognitive-behavioral counseling (CBC) intervention for smoking cessation during pregnancy and postpartum. It also explored the mediating role of cognitive-affective variables on the impact of CBC. Underserved inner city pregnant women (N = 277) were randomized to the CBC or a best practice (BP) condition, each of which consisted of two prenatal and two postpartum sessions. Assessments were obtained at baseline, late pregnancy, and 1- and 5-months postpartum. An intent-to-treat analysis found no differences between the two groups in 7-day point-prevalence abstinence. However, a respondents-only analysis revealed a significantly higher cessation rate in the CBC (37.3 %) versus the BP (19.0 %) condition at 5-months postpartum follow-up. This effect was mediated by higher quitting self-efficacy and lower cons of quitting. CBC, based on the Cognitive-Social Health Information Processing model, has the potential to increase postpartum smoking abstinence by assessing and addressing cognitive-affective barriers among women who adhere to the intervention. PMID:26335312

A soft biomolecule actuator based on a highly functionalized bacterial cellulose nano-fiber network with carboxylic acid groups.

PubMed

Wang, Fan; Jeon, Jin-Han; Park, Sukho; Kee, Chang-Doo; Kim, Seong-Jun; Oh, Il-Kwon

2016-01-07

Upcoming human-related applications such as soft wearable electronics, flexible haptic systems, and active bio-medical devices will require bio-friendly actuating materials. Here, we report a soft biomolecule actuator based on carboxylated bacterial cellulose (CBC), ionic liquid (IL), and poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) ( PSS) electrodes. Soft and biocompatible polymer-IL composites were prepared via doping of CBC with ILs. The highly conductive PSS layers were deposited on both sides of the CBC-IL membranes by a dip-coating technique to yield a sandwiched actuator system. Ionic conductivity and ionic exchange capacity of the CBC membrane can be increased up to 22.8 times and 1.5 times compared with pristine bacterial cellulose (BC), respectively, resulting in 8 times large bending deformation than the pure BC actuators with metallic electrodes in an open air environment. The developed CBC-IL actuators show significant progress in the development of biocompatible and soft actuating materials with quick response, low operating voltage and comparatively large bending deformation.

Breastfeeding trends at a Community Breastfeeding Center: an evaluative survey.

PubMed

Adams, C; Berger, R; Conning, P; Cruikshank, L; Doré, K

2001-01-01

To evaluate the Community Breastfeeding Center's (CBC) impact on clients' breastfeeding experiences. Retrospective survey; participants were mailed a questionnaire. A hospital-based drop-in center operated jointly by the Wellington-Dufferin-Guelph Health Unit and Headwaters Health Care Center and offering professional breastfeeding support and peer interaction. The 164 mothers of singleton births, both inpatients and community clients, who attended the CBC during a 10-month period in 1996-1997 and completed a survey. A mailed survey with forced-choice and open-ended questions. Of the respondents, 90.9% rated their overall CBC experience as excellent or good. Seventy-three percent of respondents breastfed for 4 months or longer. Primiparae and mothers of preterm infants tended to visit the CBC more frequently, while achieving duration rates similar to other subgroups. Returning to work was the reason most frequently cited for stopping breastfeeding (35%). The CBC is an effective community support strategy to lengthen breastfeeding duration and enhance clients' satisfaction with their breastfeeding experience.

Proving Chaotic Behavior of CBC Mode of Operation

NASA Astrophysics Data System (ADS)

Abidi, Abdessalem; Wang, Qianxue; Bouallegue, Belgacem; Machhout, Mohsen; Guyeux, Christophe

2016-06-01

The cipher block chaining (CBC) mode of operation was invented by IBM (International Business Machine) in 1976. It presents a very popular way of encrypting that is used in various applications. In this paper, we have mathematically proven that, under some conditions, the CBC mode of operation can admit a chaotic behavior according to Devaney. Some cases will be properly studied in order to provide evidence for this idea.

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

PubMed Central

Maione, Sabatino; Piscitelli, Fabiana; Gatta, Luisa; Vita, Daniela; De Petrocellis, Luciano; Palazzo, Enza; de Novellis, Vito; Di Marzo, Vincenzo

2011-01-01

BACKGROUND AND PURPOSE Two non-psychoactive cannabinoids, cannabidiol (CBD) and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved in nociceptive mechanisms, including transient receptor potential (TRP) channels of vanilloid type-1 (TRPV1) and of ankyrin type-1 (TRPA1), the equilibrative nucleoside transporter and proteins facilitating endocannabinoid inactivation. Here we have tested these two cannabinoids on the activity of the descending pathway of antinociception. EXPERIMENTAL APPROACH Electrical activity of ON and OFF neurons of the rostral ventromedial medulla in anaesthetized rats was recorded extracellularly and tail flick latencies to thermal stimuli were measured. CBD or CBC along with various antagonists were injected into the ventrolateral periaqueductal grey. KEY RESULTS Cannabidiol and CBC dose-dependently reduced the ongoing activity of ON and OFF neurons in anaesthetized rats, whilst inducing antinociceptive responses in the tail flick-test. These effects were maximal with 3 nmol CBD and 6 nmol CBC, and were antagonized by selective antagonists of cannabinoid CB1 adenosine A1 and TRPA1, but not of TRPV1, receptors. Both CBC and CBD also significantly elevated endocannabinoid levels in the ventrolateral periaqueductal grey. A specific agonist at TRPA1 channels and a synthetic inhibitor of endocannabinoid cellular reuptake exerted effects similar to those of CBC and CBD. CONCLUSIONS AND IMPLICATIONS CBD and CBC stimulated descending pathways of antinociception and caused analgesia by interacting with several target proteins involved in nociceptive control. These compounds might represent useful therapeutic agents with multiple mechanisms of action. PMID:20942863

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

PubMed Central

Izzo, Angelo A; Capasso, Raffaele; Aviello, Gabriella; Borrelli, Francesca; Romano, Barbara; Piscitelli, Fabiana; Gallo, Laura; Capasso, Francesco; Orlando, Pierangelo; Di Marzo, Vincenzo

2012-01-01

BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states. EXPERIMENTAL APPROACH Inflammation was induced in the mouse small intestine by croton oil. Endocannabinoid (anandamide and 2-arachidonoyl glycerol), palmitoylethanolamide and oleoylethanolamide levels were measured by liquid chromatography-mass spectrometry; TRPA1 and cannabinoid receptors were analysed by quantitative RT-PCR; upper gastrointestinal transit, colonic propulsion and whole gut transit were evaluated in vivo; contractility was evaluated in vitro by stimulating the isolated ileum, in an organ bath, with ACh or electrical field stimulation (EFS). KEY RESULTS Croton oil administration was associated with decreased levels of anandamide (but not 2-arachidonoyl glycerol) and palmitoylethanolamide, up-regulation of TRPA1 and CB1 receptors and down-regulation of CB2 receptors. Ex vivo CBC did not change endocannabinoid levels, but it altered the mRNA expression of TRPA1 and cannabinoid receptors. In vivo, CBC did not affect motility in control mice, but normalized croton oil-induced hypermotility. In vitro, CBC reduced preferentially EFS- versus ACh-induced contractions. Both in vitro and in vivo, the inhibitory effect of CBC was not modified by cannabinoid or TRPA1 receptor antagonists. CONCLUSION AND IMPLICATIONS CBC selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1. PMID:22300105

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brooks, Jennifer D., E-mail: brooksj@mskcc.org; Boice, John D.; Stovall, Marilyn

Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computedmore » to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.« less

Reduction of low potential electron acceptors requires the CbcL inner membrane cytochrome of Geobacter sulfurreducens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zacharoff, Lori; Chan, Chi Ho; Bond, Daniel R.

2015-09-05

The respiration of metals by the bacterium Geobacter sulfurreducens requires electrons generated by metabolism to pass from the interior of the cell to electron acceptors beyond the cell membranes. The G. sulfurreducens inner membrane multiheme c-type cytochrome ImcH is required for respiration to extracellular electron acceptors with redox potentials greater than - 0.1 V vs. SHE, but ImcH is not essential for electron transfer to lower potential acceptors. In contrast, deletion of cbcL, encoding an inner membrane protein consisting of b-type and multiheme c-type cytochrome domains, severely affected reduction of low potential electron acceptors such as Fe(III)-oxides and electrodes poisedmore » at - 0.1 V vs. SHE. Catalytic cyclic voltammetry of a ΔcbcL strain growing on poised electrodes revealed a 50 mV positive shift in driving force required for electron transfer out of the cell. In non-catalytic conditions, low-potential peaks present in wild type biofilms were absent in ΔcbcL mutants. Expression of cbcL in trans increased growth at low redox potential and restored features to cyclic voltammetry. This evidence supports a model where CbcL is a component of a second electron transfer pathway out of the G. sulfurreducens inner membrane that dominates when redox potential is at or below - 0.1 V vs. SHE.« less

Reduction of low potential electron acceptors requires the CbcL inner membrane cytochrome of Geobacter sulfurreducens.

PubMed

Zacharoff, Lori; Chan, Chi Ho; Bond, Daniel R

2016-02-01

The respiration of metals by the bacterium Geobacter sulfurreducens requires electrons generated by metabolism to pass from the interior of the cell to electron acceptors beyond the cell membranes. The G. sulfurreducens inner membrane multiheme c-type cytochrome ImcH is required for respiration to extracellular electron acceptors with redox potentials greater than -0.1 V vs. SHE, but ImcH is not essential for electron transfer to lower potential acceptors. In contrast, deletion of cbcL, encoding an inner membrane protein consisting of b-type and multiheme c-type cytochrome domains, severely affected reduction of low potential electron acceptors such as Fe(III)-oxides and electrodes poised at -0.1 V vs. SHE. Catalytic cyclic voltammetry of a ΔcbcL strain growing on poised electrodes revealed a 50 mV positive shift in driving force required for electron transfer out of the cell. In non-catalytic conditions, low-potential peaks present in wild type biofilms were absent in ∆cbcL mutants. Expression of cbcL in trans increased growth at low redox potential and restored features to cyclic voltammetry. This evidence supports a model where CbcL is a component of a second electron transfer pathway out of the G. sulfurreducens inner membrane that dominates when redox potential is at or below -0.1 V vs. SHE. Copyright © 2015. Published by Elsevier B.V.

Rapid and sensitive detection of Citrus Bacterial Canker by loop-mediated isothermal amplification combined with simple visual evaluation methods

PubMed Central

2010-01-01

Background Citrus Bacterial Canker (CBC) is a major, highly contagious disease of citrus plants present in many countries in Asia, Africa and America, but not in the Mediterranean area. There are three types of Citrus Bacterial Canker, named A, B, and C that have different genotypes and posses variation in host range within citrus species. The causative agent for type A CBC is Xanthomonas citri subsp. citri, while Xanthomonas fuscans subsp. aurantifolii, strain B causes type B CBC and Xanthomonas fuscans subsp. aurantifolii strain C causes CBC type C. The early and accurate identification of those bacteria is essential for the protection of the citrus industry. Detection methods based on bacterial isolation, antibodies or polymerase chain reaction (PCR) have been developed previously; however, these approaches may be time consuming, laborious and, in the case of PCR, it requires expensive laboratory equipment. Loop-mediated isothermal amplification (LAMP), which is a novel isothermal DNA amplification technique, is sensitive, specific, fast and requires no specialized laboratory equipment. Results A loop-mediated isothermal amplification assay for the diagnosis of Citrus Bacterial Canker (CBC-LAMP) was developed and evaluated. DNA samples were obtained from infected plants or cultured bacteria. A typical ladder-like pattern on gel electrophoresis was observed in all positive samples in contrast to the negative controls. In addition, amplification products were detected by visual inspection using SYBRGreen and using a lateral flow dipstick, eliminating the need for gel electrophoresis. The sensitivity and specificity of the assay were evaluated in different conditions and using several sample sources which included purified DNA, bacterium culture and infected plant tissue. The sensitivity of the CBC-LAMP was 10 fg of pure Xcc DNA, 5 CFU in culture samples and 18 CFU in samples of infected plant tissue. No cross reaction was observed with DNA of other phytopathogenic bacteria. The assay was capable of detecting CBC-causing strains from several geographical origins and pathotypes. Conclusions The CBC-LAMP technique is a simple, fast, sensitive and specific method for the diagnosis of Citrus Bacterial Canker. This method can be useful in the phytosanitary programs of the citrus industry worldwide. PMID:20565886

Detecting Infections Rapidly and Easily for Candidemia Trial (DIRECT1): A Prospective, Multicenter Study of the T2Candida Panel

PubMed Central

Clancy, Cornelius J; Pappas, Peter; Vazquez, Jose; Judson, Marc A; Tobin, Ellis; Kontoyiannis, Dimitrios P; Thompson, George R; Reboli, Annette; Garey, Kevin W; Greenberg, Richard N; Ostrosky-Zeichner, Luis; Wu, Alan; Lyon, G Marshall; Apewokin, Senu; Nguyen, M Hong; Caliendo, Angela

2017-01-01

Abstract Background Blood cultures (BC) are the diagnostic gold standard for candidemia, but sensitivity is <50%. T2 Candida (T2) is a novel, FDA-approved nanodiagnostic panel, which utilizes T2 magnetic resonance and a dedicated instrument to detect Candida within whole blood samples. Methods Candidemic adults were identified at 14 centers by diagnostic BC (dBC). Follow-up blood samples were collected from all patients (pts) for testing by T2 and companion BC (cBC). T2 was run-in batch at a central lab; results are reported qualitatively for three groups of spp. (Candida albicans/C. tropicalis (CA/CT), C. glabrata/C. krusei (CG/CK), or C. parapsilosis (CP)). T2 and cBC were defined as positive (+) if they detected a sp. identified in dBC. Results 152 patients were enrolled (median age: 54 yrs (18–93); 54% (82) men). Candidemia risk factors included indwelling catheters (82%, 125), abdominal surgery (24%, 36), transplant (22%, 33), cancer (22%, 33), hemodialysis (17%, 26), neutropenia (10%, 15). Mean times to Candida detection/spp. identification by dBC were 47/133 hours (2/5.5 d). dBC revealed CA (30%, 46), CG (29%, 45), CP (28%, 43), CT (11%, 17) and CK (3%, 4). Mean time to collection of T2/cBC was 62 hours (2.6 d). 74% (112) of patients received antifungal (AF) therapy prior to T2/cBC (mean: 55 hours (2.3 d)). Overall, T2 results were more likely than cBC to be + (P < 0.0001; Table), a result driven by performance in AF-treated patients (P < 0.0001). T2 was more likely to be + among patients originally infected with CA (61% (28) vs. 20% (9); P = 0.001); there were trends toward higher positivity in patients infected with CT (59% (17) vs. 23% (4; P = 0.08) and CP (42% (18) vs. 28% (12); P = 0.26). T2 was + in 89% (32/36) of patients with + cBC. Conclusion T2 was sensitive for diagnosing candidemia at the time of + cBC, and it was significantly more like to be + than cBC among AF-treated patients. T2 is an important advance in the diagnosis of candidemia, which is likely to be particularly useful in patients receiving prophylactic, pre-emptive or empiric AF therapy. Test results, n (%) Pt group (n) T2+ T2- cBC+ cBC- T2+/cBC+ T2+/cBC- T2-/cBC+ T2-/cBC- All (152) 69 
(45%) 83 
(55%) 36 
(24%) 116 
(76%) 32 
(21%) 37 
(24%) 4 
(3%) 79 
(52%) Prior AF (112) 55 
(49%) 57 
(51%) 23 
(20%) 89 
(80%) 20 
(18%) 35 
(31%) 3 
(3%) 54 
(48%) No AF (40) 14 
(35%) 26 
(65%) 13 
(32%) 27 
(68%) 12 
(30%) 2 
(5%) 1 
(2%) 25 
(62%) Disclosure D. P. Kontoyiannis, Pfizer: Research Contractor, Research support and Speaker honorarium; Astellas: Research Contractor, Research support and Speaker honorarium; Merck: Honorarium, Speaker honorarium; Cidara: Honorarium, Speaker honorarium; Amplyx: Honorarium, Speaker honorarium; F2G: Honorarium, Speaker honorarium; L. Ostrosky-Zeichner, Astellas: Consultant and Grant Investigator, Consulting fee and Research grant; Merck: Scientific Advisor and Speaker’s Bureau, Consulting fee and Speaker honorarium; Pfizer: Grant Investigator and Speaker’s Bureau, Grant recipient and Speaker honorarium; Scynexis: Grant Investigator and Scientific Advisor, Consulting fee and Grant recipient; Cidara: Grant Investigator and Scientific Advisor, Consulting fee and Research grant; S. Apewokin, T2 biosystems: Investigator, Research support; Astellas: Scientific Advisor, Consulting fee

Fuel loading of PeBR for a long operation life on the lunar surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schriener, T. M.; Chemical and Nuclear Engineering Dept., Univ. of New Mexico, Albuquerque, NM; El-Genk, M. S.

2012-07-01

The Pellet Bed Reactor (PeBR) power system could provide 99.3 kW e to a lunar outpost for 66 full power years and is designed for no single point failures. The core of this fast energy spectrum reactor consists of three sectors that are neutronically and thermally coupled, but hydraulically independent. Each sector has a separate Closed Brayton Cycle (CBC) loop for energy conversion and separate water heat-pipes radiator panels for heat rejection. He-Xe (40 g/mole) binary gas mixture serves as the reactor coolant and CBC working fluid. On the lunar surface, the emplaced PeBR below grade is loaded with sphericalmore » fuel pellets (1-cm in dia.). It is launched unfueled and the pellets are launched in separate subcritical canisters, one for each core sector. This paper numerically simulates the transient loading of a core sector with fuel pellets on the Moon. The simulation accounts for the dynamic interaction of the pellets during loading and calculates the axial and radial distributions of the volume porosity in the sector. The pellets pack randomly with a volume porosity of 0.39 - 0.41 throughout most of the sector, except near the walls the local porosity is higher. (authors)« less

Fragmentation of Red Blood Cells Caused Pseudothrombocytosis in a Patient.

PubMed

Tang, Wenjun; Tang, Chunhua; Zheng, Jianfeng; He, Yongling; Lu, Fangfang

2018-06-01

Pseudothrombocytopenia, caused by platelet (PLT) clumping, is often found in clinical studies [1]. However, pseudothrombocytosis resulting from the fragmentation of red blood cells (RBCs) is a very rare phenomenon. EDTA-K2 anticoagulation was used on a sample of venous blood extracted from the patient. A Symex XN9000 automatic blood analyzer was used to conduct CBC + DIFF mode and CBC + DIFF + RET mode tests, stained smear microscopy. The Symex XN9000 automatic blood analyzer was used to conduct CBC + DIFF mode test; PLTs were measured at 570 x 109/L. Stained smear microscopy revealed the number of PLTs did not conform to the instrument measured 570 x 109/L. "RET" alarm instrument, switch to CBC + DIFF + RET mode for testing. The second test result showed PLTs at 128 x 109/L, which accords with artificial microscopy. This was a case of a very rare phenomenon: the fragmentation of RBCs caused pseudothrombocytosis.

Perceptions of Contralateral Breast Cancer Risk: A Prospective, Longitudinal Study.

PubMed

Portschy, Pamela R; Abbott, Andrea M; Burke, Erin E; Nzara, Rumbidzayi; Marmor, Schelomo; Kuntz, Karen M; Tuttle, Todd M

2015-11-01

An increasing proportion of breast cancer patients undergo contralateral prophylactic mastectomy (CPM) to reduce their risk of contralateral breast cancer (CBC). Our goal was to evaluate CBC risk perception changes over time among breast cancer patients. We conducted a prospective, longitudinal study of women with newly diagnosed unilateral breast cancer. Patients completed a survey before and approximately 2 years after treatment. Survey questions used open-ended responses or 5-point Likert scale scoring (e.g., 5 = very likely, 1 = not at all likely). A total of 74 women completed the presurgical treatment survey, and 43 completed the postsurgical treatment survey. Baseline characteristics were not significantly different between responders and nonresponders of the follow-up survey. The mean estimated 10-year risk of CBC was 35.7 % on the presurgical treatment survey and 13.8 % on the postsurgical treatment survey (p < 0.001). The perceived risks of developing cancer in the same breast and elsewhere in the body significantly decreased between surveys. Both CPM and non-CPM (breast-conserving surgery or unilateral mastectomy) patients' perceived risk of CBC significantly decreased from pre- to postsurgical treatment surveys. Compared with non-CPM patients, CPM patients had a significantly lower perceived 10-year risk of CBC (5.8 vs. 17.3 %, p = 0.046) on postsurgical treatment surveys. The perceived risk of CBC significantly attenuated over time for both CPM and non-CPM patients. These data emphasize the importance of early physician counseling and improvement in patient education to provide women with accurate risk information before they make surgical treatment decisions.

Complete blood count reference values of cord blood in Taiwan and the influence of gender and delivery route on them.

PubMed

Chang, Yu-Hsun; Yang, Shang-Hsien; Wang, Tso-Fu; Lin, Teng-Yi; Yang, Kuo-Liang; Chen, Shu-Huey

2011-06-01

Cord blood banking has become more popular in recent years. Checking cord blood complete blood count (CBC) and white blood cell (WBC) differential counts (DCs) is essential before cryopreserving the cord blood units. Therefore, establishing the normal reference values of cord blood CBC and WBC DC is important in clinical practice and research. To obtain a large-scale population-based normal CBC and WBC DC reference values of healthy neonates' cord blood from a public cord blood bank and to investigate the influence of the gender and delivery route. From September 2001 to November 2006, the cord blood of healthy Taiwanese neonates with gestational age 36 weeks and more were collected by Tzu Chi Cord Blood Bank with written informed consents. All cord blood samples were analyzed by Sysmex XE2100 automated hematology analyzer (Sysmex Corporation, Kobe, Japan) to obtain the CBC. The WBC DC was calculated by manual method. We used Student's t test and Mann-Whitney U test for investigating the influences of gender and delivery route on the CBC and WBC DC reference values. The results were presented by mean±standard deviation or 2.5-97.5th percentiles. In the study period, totally 5602 cord blood samples were collected eligibly for analysis. The cord blood CBC and WBC DC normal reference values were calculated. The female neonates had significantly higher mean corpuscular volume, platelet count, and WBC count, but lower red blood cell (RBC) count, hemoglobin (Hb), hematocrit, and mean corpuscular Hb concentration values (p<0.001). Newborns through vaginal delivery had significantly higher RBC count, Hb, hematocrit, platelet count, and WBC count (p<0.001). The percentages of some different types WBC were significantly influenced by gender and delivery routes. Male babies had higher lymphocyte, monocyte, eosinophil, basophil, and nucleated RBC ratios than the female neonates. Newborns through cesarean section had significantly lower neutrophil, monocyte, and nucleated RBC ratios, but higher lymphocyte and eosinophil ratios, than newborns through vaginal delivery. We successfully obtained the normal CBC and WBC DC reference values of the cord blood in Taiwan. Gender and delivery routes were important confounding factors that influenced the cord blood CBC and WBC DC values. Copyright © 2011. Published by Elsevier B.V.

A randomized trial examining the effects of Conjoint Behavioral Consultation in rural schools: Student outcomes and the mediating role of the teacher-parent relationship.

PubMed

Sheridan, Susan M; Witte, Amanda L; Holmes, Shannon R; Coutts, Michael J; Dent, Amy L; Kunz, Gina M; Wu, ChaoRong

2017-04-01

The results of a large-scale randomized controlled trial of Conjoint Behavioral Consultation (CBC) on student outcomes and teacher-parent relationships in rural schools are presented. CBC is an indirect service delivery model that addresses concerns shared by teachers and parents about students. In the present study, the intervention was aimed at promoting positive school-related social-behavioral skills and strengthening teacher-parent relationships in rural schools. Participants were 267 students in grades K-3, their parents, and 152 teachers in 45 Midwest rural schools. Results revealed that, on average, improvement among students whose parents and teachers experienced CBC significantly outpaced that of control students in their teacher-reported school problems and observational measures of their inappropriate (off-task and motor activity) and appropriate (on-task and social interactions) classroom behavior. In addition, teacher responses indicated significantly different rates of improvement in their relationship with parents in favor of the CBC group. Finally, the teacher-parent relationship was found to partially mediate effects of CBC on several student outcomes. Unique contributions of this study, implications of findings for rural students, study limitations and suggestions for future research are discussed. Copyright © 2016 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

Development of thin wraparound junction silicon solar cells

NASA Technical Reports Server (NTRS)

Ho, F.; Iles, P. A.

1981-01-01

The state of the art technologies was applied to fabricate 50 micro thick 2x4 cm, coplanar back contact (CBC) solar cells with AMO efficiency above 12%. A requirement was that the cells have low solar absorptance. A wraparound junction (WAJ) with wraparound metallization was chosen. This WAJ approach avoided the need for very complex fixturing, especially during rotation of the cells for providing adequate contacts over dielectric edge layers. The contact adhesion to silicon was considered better than to an insulator. It is indicated that shunt resistance caused by poor WAJ diode quality, and series resistance from the WAJ contact, give good cell performance. The cells developed reached 14 percent AMO efficiency (at 25 C), with solar absorptance values of 0.73. Space/cell environmental tests were performed on these cells and the thin CSC cells performed well. The optimized design configuration and process sequence were used to make 50 deliverable CBC cells. These cells were all above 12 percent efficiency and had an average efficiency of -13 percent. Results of environmental tests (humidity-temperature, thermal shock, and contact adherence) are also given.

Recovery of fermented inulin fiber by lactic acid bacteria (LAB) from inulin hydrolysate using fungi inulinase enzymes of Scopulariopsis sp.-CBS1 and class of Deuteromycetes-CBS4 as cholesterol binder

NASA Astrophysics Data System (ADS)

Susilowati, Agustine; Melanie, Hakiki; Maryati, Yati; Aspiyanto

2017-01-01

Fermentation of Lactobacillus Acid Bacteria (LAB) which are mixtures of Lactobacillus acidophilus, Bifidobacteriumbifidum, Lactobacillus bulgaricus and Streptococcus thermophillus on hydrolysate as a result of inulin hydrolysis using inulinase enzymes obtained from endophytic fungi ofScopulariopsis sp.-CBS1 (inulin hydrolysate of S) and Class of Deuteromycetes-CBS4 (inulin hydrolysate of D) generate potential fermented inulin fiber as cholesterol binder. Fermentation process was conducted under concentrations of inulin hydrolysate 50% (w/v), LAB 15% (v/v) and skim milk 12.5% (w/v) at room temperature and 40°C for 0, 12, 24, 36 and 48 hours, respectively. Result of experimental work showed that longer time of LAB fermentation increased total acids, TPC and CBC at pH 2, but decreased total sugar, reducing, IDF, SDF, CBC pH 2 and CBC pH 7. Based on Cholesterol Binding Capacity (CBC), optimization of fermentation process on inulin hydrolysate of S was achieved by combining treatment at 40°C for 24 hours resulted in CBC pH 2 of 19.11 mg/g TDF and inulin hydrolysate of D was achieved by fermentation at 40 °C for 48 hours resulted in CBC pH 2 of 24.28 mg/g TDF. Inulin hydrolysate of class of Deutrymecetes CBS4 fermented by LAB had better functional property as cholesterol binder than that inulin hydrolysate of S fermented by LAB. This is due to cholesterol binder and cholesterol derivatives as a result of degradation of LAB on digestive system (stomach) when compared to higher colon under optimal process condition.

A hierarchical model for regional analysis of population change using Christmas Bird Count data, with application to the American Black Duck

USGS Publications Warehouse

Link, W.A.; Sauer, J.R.; Niven, D.K.

2006-01-01

Analysis of Christmas Bird Count (CBC) data is complicated by the need to account for variation in effort on counts and to provide summaries over large geographic regions. We describe a hierarchical model for analysis of population change using CBC data that addresses these needs. The effect of effort is modeled parametrically, with parameter values varying among strata as identically distributed random effects. Year and site effects are modeled hierarchically, accommodating large regional variation in number of samples and precision of estimates. The resulting model is complex, but a Bayesian analysis can be conducted using Markov chain Monte Carlo techniques. We analyze CBC data for American Black Ducks (Anas rubripes), a species of considerable management interest that has historically been monitored using winter surveys. Over the interval 1966-2003, Black Duck populations showed distinct regional patterns of population change. The patterns shown by CBC data are similar to those shown by the Midwinter Waterfowl Inventory for the United States.

Optical design of cipher block chaining (CBC) encryption mode by using digital holography

NASA Astrophysics Data System (ADS)

Gil, Sang Keun; Jeon, Seok Hee; Jung, Jong Rae; Kim, Nam

2016-03-01

We propose an optical design of cipher block chaining (CBC) encryption by using digital holographic technique, which has higher security than the conventional electronic method because of the analog-type randomized cipher text with 2-D array. In this paper, an optical design of CBC encryption mode is implemented by 2-step quadrature phase-shifting digital holographic encryption technique using orthogonal polarization. A block of plain text is encrypted with the encryption key by applying 2-step phase-shifting digital holography, and it is changed into cipher text blocks which are digital holograms. These ciphered digital holograms with the encrypted information are Fourier transform holograms and are recorded on CCDs with 256 gray levels quantized intensities. The decryption is computed by these encrypted digital holograms of cipher texts, the same encryption key and the previous cipher text. Results of computer simulations are presented to verify that the proposed method shows the feasibility in the high secure CBC encryption system.

Evaluation of Complete Blood Count Indices (NLR, PLR, MPV/PLT, and PLCRi) in Healthy Dogs, Dogs With Periodontitis, and Dogs With Oropharyngeal Tumors as Potential Biomarkers of Systemic Inflammatory Response.

PubMed

Rejec, Ana; Butinar, Janos; Gawor, Jerzy; Petelin, Milan

2017-12-01

The aim of the study was to retrospectively assess complete blood count (CBC) indices of dogs with periodontitis (PD; n = 73) and dogs with oropharyngeal tumors (OT; n = 92) in comparison to CBC indices of healthy dogs (HD; n = 71). Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet ratio, and platelet large cell ratio index (PLCRi) were evaluated as biomarkers of systemic inflammatory response provoked by PD and OT. Results of multivariable polytomous logistic regression analysis indicated no significant associations between CBC indices and PD. Both NLR and PLCRi were significantly higher in dogs with OT when compared to HD and dogs with PD and could, therefore, indicate a tumor-associated systemic inflammatory response. Additional studies of CBC indices, along with other biomarkers of systemic inflammatory response, are recommended to validate them as reliable indicators of clinical disease activity.

Biological activity of cannabichromene, its homologs and isomers.

PubMed

Turner, C E; Elsohly, M A

1981-01-01

Cannabichromene (CBC) is one of four major cannabinoids in Cannabis sativa L. and is the second most abundant cannabinoid in drug-type cannabis. Cannabichromene and some of its homologs, analogs, and isomers were evaluated for antiinflammatory, antibacterial, and antifungal activity. Antiinflammatory activity was evaluated by the carrageenan-induced rat paw edema and the erythrocyte membrane stabilization method. In both tests, CBC was superior to phenylbutazone. Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria. Antifungal activity was evaluated using yeast-like and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.

A decision support system using combined-classifier for high-speed data stream in smart grid

NASA Astrophysics Data System (ADS)

Yang, Hang; Li, Peng; He, Zhian; Guo, Xiaobin; Fong, Simon; Chen, Huajun

2016-11-01

Large volume of high-speed streaming data is generated by big power grids continuously. In order to detect and avoid power grid failure, decision support systems (DSSs) are commonly adopted in power grid enterprises. Among all the decision-making algorithms, incremental decision tree is the most widely used one. In this paper, we propose a combined classifier that is a composite of a cache-based classifier (CBC) and a main tree classifier (MTC). We integrate this classifier into a stream processing engine on top of the DSS such that high-speed steaming data can be transformed into operational intelligence efficiently. Experimental results show that our proposed classifier can return more accurate answers than other existing ones.

Oil-Free Turbomachinery Technologies for Long-Life, Maintenance-Free Power Generation Applications

NASA Technical Reports Server (NTRS)

Dellacorte, Christopher

2013-01-01

Turbines have long been used to convert thermal energy to shaft work for power generation. Conventional turbines rely upon oil-lubricated rotor supports (bearings, seals, etc.) to achieve low wear, high efficiency and reliability. Emerging Oil-Free technologies such as gas foil bearings and magnetic bearings offer a path for reduced weight and complexity and truly maintenance free systems. Oil-Free gas turbines, using gaseous and liquid fuels are commercially available in power outputs to at least 250kWe and are gaining acceptance for remote power generation where maintenance is a challenge. Closed Brayton Cycle (CBC) turbines are an approach to power generation that is well suited for long life space missions. In these systems, a recirculating gas is heated by nuclear, solar or other heat energy source then fed into a high-speed turbine that drives an electrical generator. For closed cycle systems such as these, the working fluid also passes through the bearing compartments thus serving as a lubricant and bearing coolant. Compliant surface foil gas bearings are well suited for the rotor support systems of these advanced turbines. Foil bearings develop a thin hydrodynamic gas film that separates the rotating shaft from the bearing preventing wear. During start-up and shut down when speeds are low, rubbing occurs. Solid lubricants are used to reduce starting torque and minimize wear. Other emerging technologies such as magnetic bearings can also contribute to robust and reliable Oil-Free turbomachinery. In this presentation, Oil-Free technologies for advanced rotor support systems will be reviewed as will the integration and development processes recommended for implementation.

High Efficiency Nuclear Power Plants Using Liquid Fluoride Thorium Reactor Technology

NASA Technical Reports Server (NTRS)

Juhasz, Albert J.; Rarick, Richard A.; Rangarajan, Rajmohan

2009-01-01

An overall system analysis approach is used to propose potential conceptual designs of advanced terrestrial nuclear power plants based on Oak Ridge National Laboratory (ORNL) Molten Salt Reactor (MSR) experience and utilizing Closed Cycle Gas Turbine (CCGT) thermal-to-electric energy conversion technology. In particular conceptual designs for an advanced 1 GWe power plant with turbine reheat and compressor intercooling at a 950 K turbine inlet temperature (TIT), as well as near term 100 MWe demonstration plants with TITs of 950 and 1200 K are presented. Power plant performance data were obtained for TITs ranging from 650 to 1300 K by use of a Closed Brayton Cycle (CBC) systems code which considered the interaction between major sub-systems, including the Liquid Fluoride Thorium Reactor (LFTR), heat source and heat sink heat exchangers, turbo-generator machinery, and an electric power generation and transmission system. Optional off-shore submarine installation of the power plant is a major consideration.

Conjoint Behavioral Consultation for Children with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Garbacz, S. Andrew; McIntyre, Laura Lee

2016-01-01

The present study examined the efficacy of Conjoint Behavioral Consultation (CBC) for children with Autism Spectrum Disorder (ASD) in early elementary school. In addition, the parent-teacher relationship, parent and teacher competence in problem solving, and CBC acceptability were examined. Participants included 3 children with ASD in early…

Excerpts from the January 1993 Senate Report: The Valour and the Horror.

ERIC Educational Resources Information Center

Kirman, Joseph M.

1994-01-01

Provides an overview of the Canadian Senate report on the Canadian Broadcasting Corporation's (CBC) documentary, "The Valour and the Horror." Includes quotes from official hearings regarding the historical accuracy of the documentary film. Concludes that the CBC was not controlled adequately by its board of directors. (CFR)

Roles of Three Transporters, CbcXWV, BetT1, and BetT3, in Pseudomonas aeruginosa Choline Uptake for Catabolism ▿ †

PubMed Central

Malek, Adel A.; Chen, Chiliang; Wargo, Matthew J.; Beattie, Gwyn A.; Hogan, Deborah A.

2011-01-01

Pseudomonas aeruginosa uses the quaternary amine choline as a carbon source, osmoprotectant, and macromolecular precursor. The importance of choline in P. aeruginosa physiology is highlighted by the presence of multiple known and putative choline transporters encoded within its genome. This report describes the relative roles of three choline transporters, the ABC transporter CbcXWV and two symporters, BetT1 and BetT3, in P. aeruginosa growth on choline under osmotic conditions that are physiologically relevant to eukaryotic hosts. The increased lag phases exhibited by the ΔbetT1 and ΔbetT1 ΔbetT3 mutants relative to the wild type upon transfer to medium with choline as a sole carbon source suggested roles for BetT1 and BetT3 in cells newly exposed to choline. BetT3 and CbcXWV, but not BetT1, were sufficient to support growth on choline. betT1 and betT3 expression was regulated by the repressor BetI and choline, whereas cbcXWV expression was induced by the activator GbdR and glycine betaine. The data support a model in which, upon transfer to a choline-based medium, the glycine betaine derived from choline taken up by BetT1 and BetT3 promotes subsequent GbdR-mediated cbcXWV induction. Furthermore, growth data indicated that the relative contributions of each transporter varied under different conditions, as BetT1 and CbcXWV were the primary choline transporters under hypo-osmolar conditions whereas BetT3 was the major choline transporter under hyperosmolar conditions. This work represents the first systematic approach to unravel the mechanisms of choline uptake in P. aeruginosa, which has the most complex bacterial choline uptake systems characterized to date. PMID:21478341

Attention and Recall of Point-of-sale Tobacco Marketing: A Mobile Eye-Tracking Pilot Study.

PubMed

Bansal-Travers, Maansi; Adkison, Sarah E; O'Connor, Richard J; Thrasher, James F

2016-01-01

As tobacco advertising restrictions have increased, the retail 'power wall' behind the counter is increasingly invaluable for marketing tobacco products. The primary objectives of this pilot study were 3-fold: (1) evaluate the attention paid/fixations on the area behind the cash register where tobacco advertising is concentrated and tobacco products are displayed in a real-world setting, (2) evaluate the duration (dwell-time) of these fixations, and (3) evaluate the recall of advertising displayed on the tobacco power wall. Data from 13 Smokers (S) and 12 Susceptible or non-daily Smokers (SS) aged 180-30 from a mobile eye-tracking study. Mobile-eye tracking technology records the orientation (fixation) and duration (dwell-time) of visual attention. Participants were randomized to one of three purchase tasks at a convenience store: Candy bar Only (CO; N = 10), Candy bar + Specified cigarette Brand (CSB; N = 6), and Candy bar + cigarette Brand of their Choice (CBC; N = 9). A post-session survey evaluated recall of tobacco marketing. Key outcomes were fixations and dwell-time on the cigarette displays at the point-of-sale. Participants spent a median time of 44 seconds during the standardized time evaluated and nearly three-quarters (72%) fixated on the power wall during their purchase, regardless of smoking status (S: 77%, SS: 67%) or purchase task (CO: 44%, CSB: 71%, CBC: 100%). In the post session survey, nearly all participants (96%) indicated they noticed a cigarette brand and 64% were able to describe a specific part of the tobacco wall or recall a promotional offer. Consumers are exposed to point-of-sale tobacco marketing, regardless of smoking status. FDA should consider regulations that limit exposure to point-of-sale tobacco marketing among consumers.

Atomistic Monte Carlo Simulation of Lipid Membranes

PubMed Central

Wüstner, Daniel; Sklenar, Heinz

2014-01-01

Biological membranes are complex assemblies of many different molecules of which analysis demands a variety of experimental and computational approaches. In this article, we explain challenges and advantages of atomistic Monte Carlo (MC) simulation of lipid membranes. We provide an introduction into the various move sets that are implemented in current MC methods for efficient conformational sampling of lipids and other molecules. In the second part, we demonstrate for a concrete example, how an atomistic local-move set can be implemented for MC simulations of phospholipid monomers and bilayer patches. We use our recently devised chain breakage/closure (CBC) local move set in the bond-/torsion angle space with the constant-bond-length approximation (CBLA) for the phospholipid dipalmitoylphosphatidylcholine (DPPC). We demonstrate rapid conformational equilibration for a single DPPC molecule, as assessed by calculation of molecular energies and entropies. We also show transition from a crystalline-like to a fluid DPPC bilayer by the CBC local-move MC method, as indicated by the electron density profile, head group orientation, area per lipid, and whole-lipid displacements. We discuss the potential of local-move MC methods in combination with molecular dynamics simulations, for example, for studying multi-component lipid membranes containing cholesterol. PMID:24469314

Brazing of refractory, superalloy, and composite materials for Space Shuttle applications.

NASA Technical Reports Server (NTRS)

Beuyukian, C. S.

1972-01-01

Research work concerning the metallic portion of the shuttle-orbiter heat shield (expected to experience temperatures up to 2500 F) is described. The five metals being evaluated are TD-Ni-Cr, Cb-C129Y, Cb752, Hayes 188, and Inconel 625. Brazing techniques whereby pairs of these materials are joined into thin-membered assemblies for heat shield applications are described. Results obtained with the vacuum-furnace brazing process are examined. In addition, the use of brazed aluminum-boron metal-matrix-contoured composite structures for heat shield applications is evaluated.

Association of hematological variables and castration status at the time of arrival at a research facility with the risk of bovine respiratory disease in beef calves

USDA-ARS?s Scientific Manuscript database

The objective of this study was to analyze the association between hematological parameters (CBC) and gender at stocker receiving facility arrival and the risk of subsequent clinical bovine respiratory disease (BRD) diagnosis, and (2) to determine and evaluate the accuracy of CBC parameter threshold...

Evaluating Brain-Computer Interface Performance in an ALS Population: Checkerboard and Color Paradigms.

PubMed

Ryan, David B; Colwell, Kenneth A; Throckmorton, Chandra S; Collins, Leslie M; Caves, Kevin; Sellers, Eric W

2018-03-01

The objective of this study was to investigate the performance of 3 brain-computer interface (BCI) paradigms in an amyotrophic lateral sclerosis (ALS) population (n = 11). Using a repeated-measures design, participants completed 3 BCI conditions: row/column (RCW), checkerboard (CBW), and gray-to-color (CBC). Based on previous studies, it is hypothesized that the CBC and CBW conditions will result in higher accuracy, information transfer rate, waveform amplitude, and user preference over the RCW condition. An offline dynamic stopping simulation will also increase information transfer rate. Higher mean accuracy was observed in the CBC condition (89.7%), followed by the CBW (84.3%) condition, and lowest in the RCW condition (78.7%); however, these differences did not reach statistical significance ( P = .062). Eight of the eleven participants preferred the CBC and the remaining three preferred the CBW conditions. The offline dynamic stopping simulation significantly increased information transfer rate ( P = .005) and decreased accuracy ( P < .000). The findings of this study suggest that color stimuli provide a modest improvement in performance and that participants prefer color stimuli over monochromatic stimuli. Given these findings, BCI paradigms that use color stimuli should be considered for individuals who have ALS.

Homologues of CsLOB1 in citrus function as disease susceptibility genes in citrus canker.

PubMed

Zhang, Junli; Huguet-Tapia, Jose Carlos; Hu, Yang; Jones, Jeffrey; Wang, Nian; Liu, Sanzhen; White, Frank F

2017-08-01

The lateral organ boundary domain (LBD) genes encode a group of plant-specific proteins that function as transcription factors in the regulation of plant growth and development. Citrus sinensis lateral organ boundary 1 (CsLOB1) is a member of the LBD family and functions as a disease susceptibility gene in citrus bacterial canker (CBC). Thirty-four LBD members have been identified from the Citrus sinensis genome. We assessed the potential for additional members of LBD genes in citrus to function as surrogates for CsLOB1 in CBC, and compared host gene expression on induction of different LBD genes. Using custom-designed transcription activator-like (TAL) effectors, two members of the same clade as CsLOB1, named CsLOB2 and CsLOB3, were found to be capable of functioning similarly to CsLOB1 in CBC. RNA sequencing and quantitative reverse transcription-polymerase chain reaction analyses revealed a set of cell wall metabolic genes that are associated with CsLOB1, CsLOB2 and CsLOB3 expression and may represent downstream genes involved in CBC. © 2016 BSPP AND JOHN WILEY & SONS LTD.

Consensus-based methodology for detection communities in multilayered networks

NASA Astrophysics Data System (ADS)

Karimi-Majd, Amir-Mohsen; Fathian, Mohammad; Makrehchi, Masoud

2018-03-01

Finding groups of network users who are densely related with each other has emerged as an interesting problem in the area of social network analysis. These groups or so-called communities would be hidden behind the behavior of users. Most studies assume that such behavior could be understood by focusing on user interfaces, their behavioral attributes or a combination of these network layers (i.e., interfaces with their attributes). They also assume that all network layers refer to the same behavior. However, in real-life networks, users' behavior in one layer may differ from their behavior in another one. In order to cope with these issues, this article proposes a consensus-based community detection approach (CBC). CBC finds communities among nodes at each layer, in parallel. Then, the results of layers should be aggregated using a consensus clustering method. This means that different behavior could be detected and used in the analysis. As for other significant advantages, the methodology would be able to handle missing values. Three experiments on real-life and computer-generated datasets have been conducted in order to evaluate the performance of CBC. The results indicate superiority and stability of CBC in comparison to other approaches.

High Efficiency Nuclear Power Plants using Liquid Fluoride Thorium Reactor Technology

NASA Technical Reports Server (NTRS)

Juhasz, Albert J.; Rarick, Richard A.; Rangarajan, Rajmohan

2009-01-01

An overall system analysis approach is used to propose potential conceptual designs of advanced terrestrial nuclear power plants based on Oak Ridge National Laboratory (ORNL) Molten Salt Reactor (MSR) experience and utilizing Closed Cycle Gas Turbine (CCGT) thermal-to-electric energy conversion technology. In particular conceptual designs for an advanced 1 GWe power plant with turbine reheat and compressor intercooling at a 950 K turbine inlet temperature (TIT), as well as near term 100 MWe demonstration plants with TITS of 950 K and 1200 K are presented. Power plant performance data were obtained for TITS ranging from 650 to 1300 K by use of a Closed Brayton Cycle (CBC) systems code which considered the interaction between major sub-systems, including the Liquid Fluoride Thorium Reactor (LFTR), heat source and heat sink heat exchangers, turbo -generator machinery, and an electric power generation and transmission system. Optional off-shore submarine installation of the power plant is a major consideration.

Survey material choices in haematology EQA: a confounding factor in automated counting performance assessment.

PubMed

De la Salle, Barbara

2017-02-15

The complete blood count (CBC) is one of the most frequently requested tests in laboratory medicine, performed in a range of healthcare situations. The provision of an ideal assay material for external quality assessment is confounded by the fragility of the cellular components of blood, the lack of commutability of stabilised whole blood material and the lack of certified reference materials and methods to which CBC results can be traced. The choice of assay material between fresh blood, extended life assay material and fully stabilised, commercially prepared, whole blood material depends upon the scope and objectives of the EQA scheme. The introduction of new technologies in blood counting and the wider clinical application of parameters from the extended CBC will bring additional challenges for the EQA provider.

Closed Brayton cycle power conversion systems for nuclear reactors :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Steven A.; Lipinski, Ronald J.; Vernon, Milton E.

2006-04-01

This report describes the results of a Sandia National Laboratories internally funded research program to study the coupling of nuclear reactors to gas dynamic Brayton power conversion systems. The research focused on developing integrated dynamic system models, fabricating a 10-30 kWe closed loop Brayton cycle, and validating these models by operating the Brayton test-loop. The work tasks were performed in three major areas. First, the system equations and dynamic models for reactors and Closed Brayton Cycle (CBC) systems were developed and implemented in SIMULINKTM. Within this effort, both steady state and dynamic system models for all the components (turbines, compressors,more » reactors, ducting, alternators, heat exchangers, and space based radiators) were developed and assembled into complete systems for gas cooled reactors, liquid metal reactors, and electrically heated simulators. Various control modules that use proportional-integral-differential (PID) feedback loops for the reactor and the power-conversion shaft speed were also developed and implemented. The simulation code is called RPCSIM (Reactor Power and Control Simulator). In the second task an open cycle commercially available Capstone C30 micro-turbine power generator was modified to provide a small inexpensive closed Brayton cycle test loop called the Sandia Brayton test-Loop (SBL-30). The Capstone gas-turbine unit housing was modified to permit the attachment of an electrical heater and a water cooled chiller to form a closed loop. The Capstone turbine, compressor, and alternator were used without modification. The Capstone systems nominal operating point is 1150 K turbine inlet temperature at 96,000 rpm. The annular recuperator and portions of the Capstone control system (inverter) and starter system also were reused. The rotational speed of the turbo-machinery is controlled by adjusting the alternator load by using the electrical grid as the load bank. The SBL-30 test loop was operated at the manufacturers site (Barber-Nichols Inc.) and installed and operated at Sandia. A sufficiently detailed description of the loop is provided in this report along with the design characteristics of the turbo-alternator-compressor set to allow other researchers to compare their results with those measured in the Sandia test-loop. The third task consisted of a validation effort. In this task the test loop was operated and compared with the modeled results to develop a more complete understanding of this electrically heated closed power generation system and to validate the model. The measured and predicted system temperatures and pressures are in good agreement, indicating that the model is a reasonable representation of the test loop. Typical deviations between the model and the hardware results are less than 10%. Additional tests were performed to assess the capability of the Brayton engine to continue to remove decay heat after the reactor/heater is shutdown, to develop safe and effective control strategies, and to access the effectiveness of gas inventory control as an alternative means to provide load following. In one test the heater power was turned off to simulate a rapid reactor shutdown, and the turbomachinery was driven solely by the sensible heat stored in the heater for over 71 minutes without external power input. This is an important safety feature for CBC systems as it means that the closed Brayton loop will keep cooling the reactor without the need for auxiliary power (other than that needed to circulate the waste heat rejection coolant) provided the heat sink is available.« less

Class, Culture, and Curriculum: A Study of Continuity and Change in a Catholic School. EED433 Management of Resources in Schools.

ERIC Educational Resources Information Center

Angus, Lawrence

This monograph presents a fictionalized case study of a real Catholic school in Australian society, Christian Brothers College (C.B.C.), which illustrates the manner in which "forces" for both continuity and change are negotiated at C.B.C. After a brief introduction, the volume opens with four thematic papers by separate authors,…

Population trends for North American winter birds based on hierarchical models

USGS Publications Warehouse

Soykan, Candan U.; Sauer, John; Schuetz, Justin G.; LeBaron, Geoffrey S.; Dale, Kathy; Langham, Gary M.

2016-01-01

Managing widespread and persistent threats to birds requires knowledge of population dynamics at large spatial and temporal scales. For over 100 yrs, the Audubon Christmas Bird Count (CBC) has enlisted volunteers in bird monitoring efforts that span the Americas, especially southern Canada and the United States. We employed a Bayesian hierarchical model to control for variation in survey effort among CBC circles and, using CBC data from 1966 to 2013, generated early-winter population trend estimates for 551 species of birds. Selecting a subset of species that do not frequent bird feeders and have ≥25% range overlap with the distribution of CBC circles (228 species) we further estimated aggregate (i.e., across species) trends for the entire study region and at the level of states/provinces, Bird Conservation Regions, and Landscape Conservation Cooperatives. Moreover, we examined the relationship between ten biological traits—range size, population size, migratory strategy, habitat affiliation, body size, diet, number of eggs per clutch, age at sexual maturity, lifespan, and tolerance of urban/suburban settings—and CBC trend estimates. Our results indicate that 68% of the 551 species had increasing trends within the study area over the interval 1966–2013. When trends were examined across the subset of 228 species, the median population trend for the group was 0.9% per year at the continental level. At the regional level, aggregate trends were positive in all but a few areas. Negative population trends were evident in lower latitudes, whereas the largest increases were at higher latitudes, a pattern consistent with range shifts due to climate change. Nine of 10 biological traits were significantly associated with median population trend; however, none of the traits explained >34% of the deviance in the data, reflecting the indirect relationships between population trend estimates and species traits. Trend estimates based on the CBC are broadly congruent with estimates based on the North American Breeding Bird Survey, another large-scale monitoring program. Both of these efforts, conducted by citizen scientists, will be required going forward to ensure robust inference about population dynamics in the face of climate and land cover changes.

Perspectives of policy-makers and stakeholders about health care waste management in community-based care in South Africa: a qualitative study.

PubMed

Hangulu, Lydia; Akintola, Olagoke

2017-04-19

In South Africa, a new primary health care (PHC) re-engineering initiative aims to scale up the provision of community-based care (CBC). A central element in this initiative is the use of outreach teams comprising nurses and community health workers to provide care to the largely poor and marginalised communities across the country. The provision of care will inevitably lead to an increase in the amount of health care waste (HCW) generated in homes and suggests the need to pay more attention to the HCW that emanates from homes where there is care of a patient. CBC in South Africa is guided by the home-based care policy. However, this policy does not deal with issues about how HCW should be managed in CBC. This study sought to explore health care waste management (HCWM) in CBC in South Africa from the policy-makers' and stakeholders' perspective. Semi-structured interviews were conducted with 9 policy-makers and 21 stakeholders working in 29 communities in Durban, South Africa. Interviews were conducted in English; were guided by an interview guide with open-ended questions. Data was analysed thematically. The Durban Solid waste (DSW) unit of the eThekwini municipality is responsible for overseeing all waste management programmes in communities. Lack of segregation of waste and illegal dumping of waste were the main barriers to proper management practices of HCW at household level while at the municipal level, corrupt tender processes and inadequate funding for waste management programmes were identified as the main barriers. In order to address these issues, all the policy-makers and stakeholders have taken steps to collaborate and develop education awareness programmes. They also liaise with various government offices to provide resources aimed at waste management programmes. HCW is generated in CBC and it is poorly managed and treated as domestic waste. With the rollout of the new primary health care model, there is a greater need to consider HCWM in CBC. There is need for the Department of Health to work together with the municipality to ensure that they devise measures that will help to deal with improper HCWM in the communities.

Long-term decline and short-term crash of the once abundant Rusty Blackbird

USGS Publications Warehouse

Greenberg, R.; Blancher, P.; Niven, D.; Droege, S.

2008-01-01

The Rusty Blackbird (Euphagus carolinus), a formerly common breeding species of boreal wetlands, has exhibited the most marked decline of any North American landbird. North American Breeding Bird Survey (BBS) trends in abundance are estimated to be -12.5% / yr over the last 40 years, which is tantamount to a >95% cumulative decline. Trends in abundance calculated from Christmas Bird Counts (CBC) for a similar period indicate a range-wide decline of -5.6% / yr. Qualitative analyses of ornithological accounts suggest the species has been declining for over a century before the period covered by the estimated declines. Several studies document range retraction in the southern boreal forest, whereas limited data suggest that abundance may be more stable in more northerly areas. This pattern is both supported and contradicted by winter declines based in CBC data. The lower estimates of decline in the CBC data compared to BBS is consistent with the idea that the coverage of BBS is biased towards the southern boreal whereas CBC covers the entire winter range. However, the CBC declines are similar between the South Atlantic coast (with populations derived from the southeastern boreal) and the Mississippi Valley (populations from the northwest boreal). The major hypotheses for the decline include degradation of boreal habitats from logging and agricultural agricultural development, mercury contamination, and wetland desiccation resulting from global warming. Other likely reasons for decline include loss or degradation of wooded wetlands of the southeastern U.S and mortality associated with abatement efforts targeting nuisance blackbirds. We present a matrix of hypotheses and predictions that test them based on the geography of decline and more detailed indicators of population health which should form the strategic basis of future research.

Dairy foods are an important source of calcium and vitamin D among Canadian-born and Asian-born Chinese in Edmonton, Alberta.

PubMed

Yu, Yan Han; Farmer, Anna; Mager, Diana R; Willows, Noreen D

2012-03-01

Low intakes of calcium and vitamin D increase the risk for osteoporosis, bone fracture, and other health problems. This study aimed to examine the calcium and vitamin D intakes of Canadian-born Chinese (CBC) and Asian-born Chinese (ABC) in Edmonton, Canada, and to identify usual food sources of these nutrients. We hypothesized that CBC would have higher intakes of calcium and vitamin D than ABC and that the food sources of these nutrients would differ by region of birth (Canada vs Asia). Two in-person multipass 24-hour dietary recalls were administered for 1 weekday and weekend day for 81 healthy ethnically Chinese aged 18 to 58 years. The risks for calcium and vitamin D inadequacy were calculated as were the contributions of specific foods to calcium and vitamin D intakes. Calcium intake was 781 ± 337 mg/d for CBC and 809 ± 369 mg/d for ABC (P = .737). Vitamin D intake was 3.8 ± 3.4 μg/d for CBC and 5.0 ± 3.9 μg/d for ABC (P = .158). Respective risks for calcium and vitamin D inadequacy were 36% and 98% for men and 78% and 100% for women. Dairy contributed most to the calcium (43%) and vitamin D (52%) intake of participants. For ABC, soybean products contributed to 8.1% of calcium, whereas fatty fish contributed to 16.7% of vitamin D. For CBC, red meats contributed to 11.1% of vitamin D. Dietary intakes of calcium and vitamin D need to be increased in Chinese Canadians through the promotion of dairy and culturally relevant sources of these nutrients. Copyright © 2012 Elsevier Inc. All rights reserved.

Tidally-driven effluent detected by long-term temperature monitoring at the TAG hydrothermal mound, Mid-Atlantic Ridge

NASA Astrophysics Data System (ADS)

Kinoshita, M.; Von Herzen, R. P.; Matsubayashi, O.; Fujioka, K.

1998-06-01

During Aug. 13-21, 1994, temperatures and current velocity were simultaneously monitored on the TAG hydrothermal mound. Three `Giant Kelps (GKs)', vertical thermistor arrays of 50 m height, were moored on the periphery of the central black smoker complex (CBC). A `Manatee', multi-monitoring system including current velocity, was deployed 50 m east of CBC. Four `Daibutsu' geothermal probes penetrated the sediment south to west of CBC. Compilation of all data revealed semi-diurnal variations in water temperatures and current velocity, and allowed us to discuss the source of these anomalies. Temperature anomalies of GKs correlate well with current velocity, and are interpreted to be caused by the main plume from CBC that was bent over by the tidal current. We identified two types of asymmetric, periodic temperature variations at Daibutsu Probes 2 and 8, located 20 m to the south of CBC. By comparing temperatures and current velocity, they are attributed to non-buoyant effluents laterally advected by the tidal current. The source of one variation is located east to ESE of the probes, and the source of the other is located to the north. On Aug. 31, a new periodic anomaly emerged on Probe 2 with its amplitude up to 0.8°C. The 6-h offset between the new anomaly and the previous one suggests that the source of the new anomaly lies to the west of Probe 2. The heat flux of these non-buoyant effluents is estimated to range from 30 to 100 kW/m 2, which is of the same order as direct estimates of diffuse flow at the TAG mound. It suggests that a significant amount of diffuse effluent is laterally advected by the prevailing current near the seafloor.

Energy Conversion Advanced Heat Transport Loop and Power Cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oh, C. H.

2006-08-01

The Department of Energy and the Idaho National Laboratory are developing a Next Generation Nuclear Plant (NGNP) to serve as a demonstration of state-of-the-art nuclear technology. The purpose of the demonstration is two fold 1) efficient low cost energy generation and 2) hydrogen production. Although a next generation plant could be developed as a single-purpose facility, early designs are expected to be dual-purpose. While hydrogen production and advanced energy cycles are still in its early stages of development, research towards coupling a high temperature reactor, electrical generation and hydrogen production is under way. Many aspects of the NGNP must bemore » researched and developed in order to make recommendations on the final design of the plant. Parameters such as working conditions, cycle components, working fluids, and power conversion unit configurations must be understood. Three configurations of the power conversion unit were demonstrated in this study. A three-shaft design with 3 turbines and 4 compressors, a combined cycle with a Brayton top cycle and a Rankine bottoming cycle, and a reheated cycle with 3 stages of reheat were investigated. An intermediate heat transport loop for transporting process heat to a High Temperature Steam Electrolysis (HTSE) hydrogen production plant was used. Helium, CO2, and an 80% nitrogen, 20% helium mixture (by weight) were studied to determine the best working fluid in terms cycle efficiency and development cost. In each of these configurations the relative component size were estimated for the different working fluids. The relative size of the turbomachinery was measured by comparing the power input/output of the component. For heat exchangers the volume was computed and compared. Parametric studies away from the baseline values of the three-shaft and combined cycles were performed to determine the effect of varying conditions in the cycle. This gives some insight into the sensitivity of these cycles to various operating conditions as well as trade offs between efficiency and capital cost. Prametric studies were carried out on reactor outlet temperature, mass flow, pressure, and turbine cooling. Recommendations on the optimal working fluid for each configuration were made. A steady state model comparison was made with a Closed Brayton Cycle (CBC) power conversion system developed at Sandia National Laboratory (SNL). A preliminary model of the CBC was developed in HYSYS for comparison. Temperature and pressure ratio curves for the Capstone turbine and compressor developed at SNL were implemented into the HYSYS model. A comparison between the HYSYS model and SNL loop demonstrated power output predicted by HYSYS was much larger than that in the experiment. This was due to a lack of a model for the electrical alternator which was used to measure the power from the SNL loop. Further comparisons of the HYSYS model and the CBC data are recommended. Engineering analyses were performed for several configurations of the intermediate heat transport loop that transfers heat from the nuclear reactor to the hydrogen production plant. The analyses evaluated parallel and concentric piping arrangements and two different working fluids, including helium and a liquid salt. The thermal-hydraulic analyses determined the size and insulation requirements for the hot and cold leg pipes in the different configurations. Economic analyses were performed to estimate the cost of the va« less

A Randomized Trial Examining the Effects of Conjoint Behavioral Consultation in Rural Schools: Student Outcomes and the Mediating Role of the Teacher-Parent Relationship

ERIC Educational Resources Information Center

Sheridan, Susan M.; Witte, Amanda L.; Holmes, Shannon R.; Coutts, Michael J.; Dent, Amy L.; Kunz, Gina M.; Wu, ChaoRong

2017-01-01

The results of a large-scale randomized controlled trial of Conjoint Behavioral Consultation (CBC) on student outcomes and teacher-parent relationships in rural schools are presented. CBC is an indirect service delivery model that addresses concerns shared by teachers and parents about students. In the present study, the intervention was aimed at…

Supporting the Inclusion of a Student with Asperger Syndrome: A Case Study Using Conjoint Behavioural Consultation and Self-Management

ERIC Educational Resources Information Center

Wilkinson, Lee A.

2005-01-01

Conjoint behavioural consultation (CBC) is an indirect form of service delivery that combines the resources of home and school to meet the academic, social and behavioural needs of children. The purpose of this paper is to demonstrate the utility of CBC as a service delivery model for supporting the inclusion of a student with Asperger syndrome in…

Behavioural laterality as a predictor of health in captive Caribbean flamingos (Phoenicopterus ruber): an exploratory analysis.

PubMed

Anderson, Matthew J; Ialeggio, Donna M

2014-01-01

The present study sought to explore the possibility that lateral behaviour in captive Caribbean flamingos (Phoenicopterus ruber) housed at the Philadelphia Zoo (Philadelphia, PA) could be used to predict a variety of physiological measures of health obtained via complete blood counts (CBC) and plasma biochemistry analyses that were performed as part of the flock's annual physical examination. Consistent with previous research, evidence of rightward lateral neck-resting preferences were obtained, no evidence was found for the existence of leg stance preferences, and neck-resting and leg stance preferences were shown to be unrelated. Both lateral neck-resting preferences and lateral support leg preference were shown to be related to a variety of measures from the CBC and plasma biochemistry analyses. While several general trends emerged in regards to the CBC variables, the relationships between the lateral behaviours and those variables generated via plasma biochemistry analyses proved to be fewer and somewhat less consistent. Birds with rightward neck-resting preferences and birds with leftward support leg preferences generally appeared to be healthier and less stressed according to the CBC measures; however, the validity of lateral leg stance preference as a predictor of health and wellbeing is questionable given the lack of statistically significant leg stance preferences.

Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

PubMed Central

Phillips, Kelly-Anne; Milne, Roger L.; Rookus, Matti A.; Daly, Mary B.; Antoniou, Antonis C.; Peock, Susan; Frost, Debra; Easton, Douglas F.; Ellis, Steve; Friedlander, Michael L.; Buys, Saundra S.; Andrieu, Nadine; Noguès, Catherine; Stoppa-Lyonnet, Dominique; Bonadona, Valérie; Pujol, Pascal; McLachlan, Sue Anne; John, Esther M.; Hooning, Maartje J.; Seynaeve, Caroline; Tollenaar, Rob A.E.M.; Goldgar, David E.; Beth Terry, Mary; Caldes, Trinidad; Weideman, Prue C.; Andrulis, Irene L.; Singer, Christian F.; Birch, Kate; Simard, Jacques; Southey, Melissa C.; Olsson, Håkan L.; Jakubowska, Anna; Olah, Edith; Gerdes, Anne-Marie; Foretova, Lenka; Hopper, John L.

2013-01-01

Purpose To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 mutation carriers. Methods Analysis of pooled observational cohort data, self-reported at enrollment and at follow-up from the International BRCA1, and BRCA2 Carrier Cohort Study, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, and Breast Cancer Family Registry. Eligible women were BRCA1 and BRCA2 mutation carriers diagnosed with unilateral BC since 1970 and no other invasive cancer or tamoxifen use before first BC. Hazard ratios (HRs) for CBC associated with tamoxifen use were estimated using Cox regression, adjusting for year and age of diagnosis, country, and bilateral oophorectomy and censoring at contralateral mastectomy, death, or loss to follow-up. Results Of 1,583 BRCA1 and 881 BRCA2 mutation carriers, 383 (24%) and 454 (52%), respectively, took tamoxifen after first BC diagnosis. There were 520 CBCs over 20,104 person-years of observation. The adjusted HR estimates were 0.38 (95% CI, 0.27 to 0.55) and 0.33 (95% CI, 0.22 to 0.50) for BRCA1 and BRCA2 mutation carriers, respectively. After left truncating at recruitment to the cohort, adjusted HR estimates were 0.58 (95% CI, 0.29 to 1.13) and 0.48 (95% CI, 0.22 to 1.05) based on 657 BRCA1 and 426 BRCA2 mutation carriers with 100 CBCs over 4,392 person-years of prospective follow-up. HRs did not differ by estrogen receptor status of the first BC (missing for 56% of cases). Conclusion This study provides evidence that tamoxifen use is associated with a reduction in CBC risk for BRCA1 and BRCA2 mutation carriers. Further follow-up of these cohorts will provide increased statistical power for future prospective analyses. PMID:23918944

Windage Power Loss in Gas Foil Bearings and the Rotor-Stator Clearance of High Speed Generators Operating in High Pressure Environments

NASA Technical Reports Server (NTRS)

Bruckner, Robert J.

2009-01-01

Closed Brayton Cycle (CBC) and Closed Supercritical Cycle (CSC) engines are prime candidates to convert heat from a reactor into electric power for robotic space exploration and habitation. These engine concepts incorporate a permanent magnet starter/generator mounted on the engine shaft along with the requisite turbomachinery. Successful completion of the long-duration missions currently anticipated for these engines will require designs that adequately address all losses within the machine. The preliminary thermal management concept for these engine types is to use the cycle working fluid to provide the required cooling. In addition to providing cooling, the working fluid will also serve as the bearing lubricant. Additional requirements, due to the unique application of these microturbines, are zero contamination of the working fluid and entirely maintenance-free operation for many years. Losses in the gas foil bearings and within the rotor-stator gap of the generator become increasingly important as both rotational speed and mean operating pressure are increased. This paper presents the results of an experimental study, which obtained direct torque measurements on gas foil bearings and generator rotor-stator gaps. Test conditions for these measurements included rotational speeds up to 42,000 revolutions per minute, pressures up to 45 atmospheres, and test gases of nitrogen, helium, and carbon dioxide. These conditions provided a maximum test Taylor number of nearly one million. The results show an exponential rise in power loss as mean operating density is increased for both the gas foil bearing and generator windage. These typical "secondary" losses can become larger than the total system output power if conventional design paradigms are followed. A nondimensional analysis is presented to extend the experimental results into the CSC range for the generator windage.

Dietary Sodium Intakes and Food Sources of Sodium in Canadian-Born and Asian-Born Individuals of Chinese Ethnicity at a Canadian University Campus

ERIC Educational Resources Information Center

Yu, Yan Han; Farmer, Anna; Mager, Diana; Willows, Noreen

2014-01-01

Objective: To document the sodium intake and food sources of sodium of Canadian-born Chinese (CBC) and Asian-born Chinese (ABC) individuals at a Canadian university campus. Participants: Healthy adults aged 18-58 years originating from Canada, China, Hong Kong, or Taiwan were recruited from the University of Alberta (n = 40 CBC, n = 41 ABC)…

Coherent beam combination of fiber lasers with a strongly confined waveguide: numerical model.

PubMed

Tao, Rumao; Si, Lei; Ma, Yanxing; Zhou, Pu; Liu, Zejin

2012-08-20

Self-imaging properties of fiber lasers in a strongly confined waveguide (SCW) and their application in coherent beam combination (CBC) are studied theoretically. Analytical formulas are derived for the positions, amplitudes, and phases of the N images at the end of an SCW, which is important for quantitative analysis of waveguide CBC. The formulas are verified with experimental results and numerical simulation of a finite difference beam propagation method (BPM). The error of our analytical formulas is less than 6%, which can be reduced to less than 1.5% with Goos-Hahnchen penetration depth considered. Based on the theoretical model and BPM, we studied the combination of two laser beams based on an SCW. The effects of the waveguide refractive index and Gaussian beam waist are studied. We also simulated the CBC of nine and 16 fiber lasers, and a single beam without side lobes was achieved.

Aging stability of complete blood count and white blood cell differential parameters analyzed by Abbott CELL-DYN Sapphire hematology analyzer.

PubMed

Hedberg, P; Lehto, T

2009-02-01

This study presents the results of an aging stability study of complete blood count (CBC) and leukocyte differential parameters using the Abbott CELL-DYN Sapphire hematology analyzer. Stability studies showed no substantial change in CBC parameters up to 24-48 h at +23 +/- 2 degrees C (room temperature), except for optical platelet count (PLTo). For specimens aged over 24, the value of impedance platelet count yielded more reliable results than the routine PLTo. White blood cell (WBC) differential parameters, except eosinophils, were stable for up to 48 h at +23 +/- 2 degrees C. CBC parameters were stable for 72 h, except mean platelet volume, which slightly increased between 48 and 72 h, at +4 degrees C. WBC differentials were stable 48-72 h, with a slight decrease observed in absolute neutrophils and lymphocytes at +4 degrees C.

Experimental Tracking of Limit-Point Bifurcations and Backbone Curves Using Control-Based Continuation

NASA Astrophysics Data System (ADS)

Renson, Ludovic; Barton, David A. W.; Neild, Simon A.

Control-based continuation (CBC) is a means of applying numerical continuation directly to a physical experiment for bifurcation analysis without the use of a mathematical model. CBC enables the detection and tracking of bifurcations directly, without the need for a post-processing stage as is often the case for more traditional experimental approaches. In this paper, we use CBC to directly locate limit-point bifurcations of a periodically forced oscillator and track them as forcing parameters are varied. Backbone curves, which capture the overall frequency-amplitude dependence of the system’s forced response, are also traced out directly. The proposed method is demonstrated on a single-degree-of-freedom mechanical system with a nonlinear stiffness characteristic. Results are presented for two configurations of the nonlinearity — one where it exhibits a hardening stiffness characteristic and one where it exhibits softening-hardening.

Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography–Tandem Mass Spectrometry

PubMed Central

Poklis, Justin L.; Thompson, Candace C.; Long, Kelly A.; Lichtman, Aron H.; Poklis, Alphonse

2011-01-01

A liquid chromatography–tandem mass spectrometry (LC–MS–MS) method was developed for the analysis of marijuana cannabinoids in mouse brain tissue using an Applied Biosystems 3200 Q trap with a turbo V source for TurbolonSpray attached to a Shimadzu SCL HPLC system. The method included cannabichromene (CBC), cannabidiol (CBD), D9-tetrahydrocannabinol (THC), 11-hydroxytetrahydrocannabinol (11-OH-THC), and 11-nor-D9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH). These compounds were isolated by liquid-liquid extraction using cold acetonitrile. The following transition ions were monitored by multiple reaction monitoring (MRM): m/z 315>193, 315>259 for THC/CBD/CBC; m/z 331>193, 331>105 for 11-OH-THC; m/z 345>299, 345>193 for THC-COOH;c m/z 318>196 for THC-d3; m/z 334>196 for 11-OH-THC-d3, and m/z 348>302 for THCCOOH-d3. Linearity for THC, 1-OH-THC, and THC-COOH was 1-200 ng/g; for CBC and CBD, it was 0.5–20 ng/g. Within-run and between-run precisions for all the analytes yielded coefficients of variation of < 20%. Four C57BL6 mice were sacrificed 20 min after nose-only exposure to the smoke of 200 mg of marijuana containing 0.44 mg CBC, 0.93 mg CBD, and 8.81 mg THC. The mean brain concentrations were 3.9 ± 1.5 ng/g CBC, 21 ± 3.9 ng/g CBD, 364 ± 74 ng/g THC, and 28 ± 5.9 ng/g 11-OH-THC. THCCOOH was not detected. The relative mean brain cannabinoid concentrations correlated to the amounts of the cannabinoids in the inhaled marijuana. PMID:21258613

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

PubMed Central

De Petrocellis, Luciano; Ligresti, Alessia; Moriello, Aniello Schiano; Allarà, Marco; Bisogno, Tiziana; Petrosino, Stefania; Stott, Colin G; Di Marzo, Vincenzo

2011-01-01

BACKGROUND AND PURPOSE Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system. EXPERIMENTAL APPROACH The effects of 11 pure cannabinoids and botanical extracts [botanical drug substance (BDS)] from Cannabis varieties selected to contain a more abundant cannabinoid, on TRPV1, TRPV2, TRPM8, TRPA1, human recombinant diacylglycerol lipase α (DAGLα), rat brain fatty acid amide hydrolase (FAAH), COS cell monoacylglycerol lipase (MAGL), human recombinant N-acylethanolamine acid amide hydrolase (NAAA) and anandamide cellular uptake (ACU) by RBL-2H3 cells, were studied using fluorescence-based calcium assays in transfected cells and radiolabelled substrate-based enzymatic assays. Cannabinol (CBN), cannabichromene (CBC), the acids (CBDA, CBGA, THCA) and propyl homologues (CBDV, CBGV, THCV) of CBD, cannabigerol (CBG) and THC, and tetrahydrocannabivarin acid (THCVA) were also tested. KEY RESULTS CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and desensitizers, but THCV-BDS was the most potent compound at this target. CBG-BDS and THCV-BDS were the most potent rat TRPM8 antagonists. All non-acid cannabinoids, except CBC and CBN, potently activated and desensitized rat TRPV2. CBDV and all the acids inhibited DAGLα. Some BDS, but not the pure compounds, inhibited MAGL. CBD was the only compound to inhibit FAAH, whereas the BDS of CBC > CBG > CBGV inhibited NAAA. CBC = CBG > CBD inhibited ACU, as did the BDS of THCVA, CBGV, CBDA and THCA, but the latter extracts were more potent inhibitors. CONCLUSIONS AND IMPLICATIONS These results are relevant to the analgesic, anti-inflammatory and anti-cancer effects of cannabinoids and Cannabis extracts. LINKED ARTICLES This article is part of a themed issue on Cannabinoids in Biology and Medicine. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-7 PMID:21175579

Using Christmas Bird Count data in analysis of population change

USGS Publications Warehouse

Sauer, J.R.; Link, W.A.

2002-01-01

The scientific credibility of Christmas Bird Count (CBC) results depend on the development and implementation of appropriate methods of statistical analysis. The key to any successful analysis of CBC data is to begin with a careful review of how the limitations of the data are likely to influence the results of the analysis, then to choose methods of analysis that accommodate as much as possible the limitations of the survey. For our analyses of CBC data, we develop a flexible model for effort adjustment and use information from the data to guide the selection of the best model. We include geographic structuring to accommodate the regional variation in number of samples, use a model that allows for overdispersed poisson data appropriate for counts, and employ empirical Bayes procedures to accommodate differences in quality of information in regional summaries. This generalized linear model approach is very flexible, and can be applied to a variety of studies focused on factors influencing wintering bird populations. In particular, the model can be easily modified to contain covariates, allowing for assessment of associations between CBC counts and winter weather, disturbance, and a variety of other environmental factors. These new survey analysis methods have added value in that they provide insights into changes in survey design that can enhance the value of the information. The CBC has been extremely successful as a tool for increasing public interest in birding and bird conservation. Use of the information for bird conservation creates new demands on quality of information, and it is important to maintain a dialogue between users of the information, information needs for the analyses, and survey coordinators and participants. Our work as survey analysts emphasizes the value and limitations of existing data, and provides some indications of what features of the survey could be modified to make the survey a more reliable source of bird population data. Surveys only remain useful if they adapt to current needs, while still maintaining consistency with historical goals.

Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database.

PubMed

Vidal, Adriana C; Howard, Lauren E; de Hoedt, Amanda; Cooperberg, Matthew R; Kane, Christopher J; Aronson, William J; Terris, Martha K; Amling, Christopher L; Taioli, Emanuela; Fowke, Jay H; Freedland, Stephen J

2018-06-01

Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and whether results vary by race is unknown. We examined whether complete blood count (CBC) parameters were associated with PC outcomes and whether these associations varied by race. Analyses include 1,826 radical prostatectomy patients from six VA hospitals followed through medical record review for biochemical recurrence (BCR). Secondary outcomes included castration-resistant PC (CRPC), metastasis, all-cause mortality (ACM), and PC-specific mortality (PCSM). Cox-proportional hazards were used to assess the associations between pre-operative neutrophils, lymphocytes, platelets, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with each outcome. We used a Bonferroni-corrected p-value of 0.05/5 = 0.01 as the threshold for statistical significance. Of 1,826 men, 794 (43%) were black and 1,032 (57%) white. Neutrophil count (p < 0.001), NLR (p < 0.001), and PLR (p < 0.001) were significantly lower, while lymphocyte count (p < 0.001) was significantly higher in black versus white men. After adjusting for clinicopathological features, no CBC measures were significantly associated with BCR. There were no interactions between CBC and race in predicting BCR. Similarly, no CBC values were significantly associated with CRPC, metastases, or PCSM either among all men or when stratified by race. However, higher neutrophil count was associated with higher ACM risk in white men (p = 0.004). Pre-operative CBC measures were not associated with PC outcomes in black or white men undergoing radical prostatectomy, except for neutrophils-positive association with risk of ACM in white men. Whether circulating immune cell markers provide insight to the pathophysiology of PC progression or adverse treatment outcomes requires further study.

Laboratory productivity and the rate of manual peripheral blood smear review: a College of American Pathologists Q-Probes study of 95,141 complete blood count determinations performed in 263 institutions.

PubMed

Novis, David A; Walsh, Molly; Wilkinson, David; St Louis, Mary; Ben-Ezra, Jonathon

2006-05-01

Automated laboratory hematology analyzers are capable of performing differential counts on peripheral blood smears with greater precision and more accurate detection of distributional and morphologic abnormalities than those performed by manual examinations of blood smears. Manual determinations of blood morphology and leukocyte differential counts are time-consuming, expensive, and may not always be necessary. The frequency with which hematology laboratory workers perform manual screens despite the availability of labor-saving features of automated analyzers is unknown. To determine the normative rates with which manual peripheral blood smears were performed in clinical laboratories, to examine laboratory practices associated with higher or lower manual review rates, and to measure the effects of manual smear review on the efficiency of generating complete blood count (CBC) determinations. From each of 3 traditional shifts per day, participants were asked to select serially, 10 automated CBC specimens, and to indicate whether manual scans and/or reviews with complete differential counts were performed on blood smears prepared from those specimens. Sampling continued until a total of 60 peripheral smears were reviewed manually. For each specimen on which a manual review was performed, participants indicated the patient's age, hemoglobin value, white blood cell count, platelet count, and the primary reason why the manual review was performed. Participants also submitted data concerning their institutions' demographic profiles and their laboratories' staffing, work volume, and practices regarding CBC determinations. The rates of manual reviews and estimations of efficiency in performing CBC determinations were obtained from the data. A total of 263 hospitals and independent laboratories, predominantly located in the United States, participating in the College of American Pathologists Q-Probes Program. There were 95,141 CBC determinations examined in this study; participants reviewed 15,423 (16.2%) peripheral blood smears manually. In the median institution (50th percentile), manual reviews of peripheral smears were performed on 26.7% of specimens. Manual differential count review rates were inversely associated with the magnitude of platelet counts that were required by laboratory policy to trigger smear reviews and with the efficiency of generating CBC reports. Lower manual differential count review rates were associated with laboratory policies that allowed manual reviews solely on the basis of abnormal automated red cell parameters and that precluded performing repeat manual reviews within designated time intervals. The manual scan rate elevated with increased number of hospital beds. In more than one third (35.7%) of the peripheral smears reviewed manually, participants claimed to have learned additional information beyond what was available on automated hematology analyzer printouts alone. By adopting certain laboratory practices, it may be possible to reduce the rates of manual reviews of peripheral blood smears and increase the efficiency of generating CBC results.

Controlling for varying effort in count surveys --an analysis of Christmas Bird Count Data

USGS Publications Warehouse

Link, W.A.; Sauer, J.R.

1999-01-01

The Christmas Bird Count (CBC) is a valuable source of information about midwinter populations of birds in the continental U.S. and Canada. Analysis of CBC data is complicated by substantial variation among sites and years in effort expended in counting; this feature of the CBC is common to many other wildlife surveys. Specification of a method for adjusting counts for effort is a matter of some controversy. Here, we present models for longitudinal count surveys with varying effort; these describe the effect of effort as proportional to exp(B effortp), where B and p are parameters. For any fixed p, our models are loglinear in the transformed explanatory variable (effort)p and other covariables. Hence we fit a collection of loglinear models corresponding to a range of values of p, and select the best effort adjustment from among these on the basis of fit statistics. We apply this procedure to data for six bird species in five regions, for the period 1959-1988.

"Virtual shear box" experiments of stress and slip cycling within a subduction interface mélange

NASA Astrophysics Data System (ADS)

Webber, Sam; Ellis, Susan; Fagereng, Åke

2018-04-01

What role does the progressive geometric evolution of subduction-related mélange shear zones play in the development of strain transients? We use a "virtual shear box" experiment, based on outcrop-scale observations from an ancient exhumed subduction interface - the Chrystalls Beach Complex (CBC), New Zealand - to constrain numerical models of slip processes within a meters-thick shear zone. The CBC is dominated by large, competent clasts surrounded by interconnected weak matrix. Under constant slip velocity boundary conditions, models of the CBC produce stress cycling behavior, accompanied by mixed brittle-viscous deformation. This occurs as a consequence of the reorganization of competent clasts, and the progressive development and breakdown of stress bridges as clasts mutually obstruct one another. Under constant shear stress boundary conditions, the models show periods of relative inactivity punctuated by aseismic episodic slip at rapid rates (meters per year). Such a process may contribute to the development of strain transients such as slow slip.

Fourteen-year survival of Pseudomonas cepacia in a salts solution preserved with benzalkonium chloride.

PubMed Central

Geftic, S G; Heymann, H; Adair, F W

1979-01-01

A strain of Pseudomonas cepacia that survived for 14 years (1963 to 1977) as a contaminant in an inorganic salt solution which contained commercial 0.05% benzalkonium chloride (CBC) as an antimicrobial preservative, was compared to a recent clinical isolate of P. cepacia. Ammonium acetate was present in the concentrated stock CBC solution, and served as a carbon and nitrogen source for growth when carried over into the salts solution with the CBC. The isolate's resistance to pure benzalkonium chloride was increased step-wise to a concentration of 16%. Plate counts showed 4 x 10(3) colony-forming units per ml in the salts solution. Comparison of growth rates, mouse virulence, antibiotics resistance spectra, and substrate requirements disclosed no differences between the contaminant and a recently isolated clinical strain of P. cepacia. The results indicate that it is critical that pharmaceutical solutions containing benzalkonium chloride as an antimicrobial preservative be formulated without extraneous carbon and nitrogen sources or be preserved with additional antimicrobial agents. PMID:453827

Power Consumption and Calculation Requirement Analysis of AES for WSN IoT.

PubMed

Hung, Chung-Wen; Hsu, Wen-Ting

2018-05-23

Because of the ubiquity of Internet of Things (IoT) devices, the power consumption and security of IoT systems have become very important issues. Advanced Encryption Standard (AES) is a block cipher algorithm is commonly used in IoT devices. In this paper, the power consumption and cryptographic calculation requirement for different payload lengths and AES encryption types are analyzed. These types include software-based AES-CB, hardware-based AES-ECB (Electronic Codebook Mode), and hardware-based AES-CCM (Counter with CBC-MAC Mode). The calculation requirement and power consumption for these AES encryption types are measured on the Texas Instruments LAUNCHXL-CC1310 platform. The experimental results show that the hardware-based AES performs better than the software-based AES in terms of power consumption and calculation cycle requirements. In addition, in terms of AES mode selection, the AES-CCM-MIC64 mode may be a better choice if the IoT device is considering security, encryption calculation requirement, and low power consumption at the same time. However, if the IoT device is pursuing lower power and the payload length is generally less than 16 bytes, then AES-ECB could be considered.

Zirconocene mediated acetylboron chemistry.

PubMed

Jian, Zhongbao; Daniliuc, Constantin G; Kehr, Gerald; Erker, Gerhard

2018-05-31

The methyl zirconocene complex Cp*2Zr(Me)OMes reacts with H3C-B(C6F5)2 and CO to give the respective acetyl(methyl)borate Zr complex. Cp*2Zr(H)OMes reacts with H3C-B(C6F5)2 and CO to give the respective acetyl(hydrido)borate Zr product, admixed with a minor amount of the formyl(methyl)borate Zr complex isomer. Prolonged exposure to CO under close to ambient conditions results in the uptake of another CO equivalent to yield the corresponding borata-β-lactone zirconocene product.

The PyCBC search for binary black hole coalescences in Advanced LIGO's first observing run

NASA Astrophysics Data System (ADS)

Willis, Joshua; LIGO Scientific Collaboration

2017-01-01

Advanced LIGO's first observing run saw the first detections of binary black hole coalescences. We describe the PyCBC matched filter analysis, and the results of that search for binary systems with total mass up to 100 solar masses. This is a matched filter search for general-relativistic signals from binary black hole systems. Two signals, GW150914 and GW151226, were identified with very high significance, and a third possible signal, LVT151012, was found, though at much lower significance. Supported by NSF award PHY-1506254.

Operational effectiveness of guidelines on complete breast-feeding cessation to reduce mother-to-child transmission of HIV: results from a prospective observational cohort study at routine prevention of mother-to-child transmission sites, South Africa.

PubMed

Goga, Ameena E; Van Wyk, Brian; Doherty, Tanya; Colvin, Mark; Jackson, Debra J; Chopra, Mickey

2009-04-15

Until 2006, HIV-positive women who chose to exclusively breast-feed were advised to completely stop breast-feeding by 6 months. We investigated operational feasibility and predictors of complete breast-feeding cessation (CBC). A prospective observational cohort study at 3 routine prevention of mother-to-child transmission sites, South Africa. Data on "complete breast-feeding cessation at 24 weeks" and "not breast-feeding (NBF) for 4 days before the last follow-up visit at or before 24 weeks" were gathered during home visits (3, 5, 7, 9, 12, 16, 20, and 24 weeks). The main subgroup of interest for this analysis was women practicing exclusive breast-feeding/predominant breast-feeding at 3 weeks. Univariate analysis, logistic regression, Kaplan-Meier Survival analysis, and Cox regression were performed. Eighty-eight women (43.6%) reported CBC. "Health staff suggesting formula use: [OR(a) 4.39 (1.76-10.97)] and "infant hospitalization" [OR(a) 3.27 (1.37-7.79)] were the only significant predictors of CBC. The probability of NBF at 5, 7, 9, 12, 16, 20, and 24 weeks was 2.8% [95% confidence interval (CI) 1.8% to 3.8%], 4.3% (3.0% to 5.6%), 5.9% (4.4% to 7.4%, 9.8% (7.9% to 11.7%), 16.1 (13.8% to 18.4%), 23.1% (20.5% to 25.7%), and 37.6% (34.6% to 40.6%), respectively. Infant HIV status [hazard ratio 5.5 95% CI 2.4 to 12.5] was the only predictor of infant death. NBF was not protective against 9-month infant HIV or death in univariate and multivariable analysis. At programmatic level, CBC by 24 weeks is uncommon, and success seems unrelated to predetermined social, economic, and environmental (acceptable, feasible, affordable, sustainable, and safe AFASS) criteria. Thus at this level, activities that encourage CBC (amongst women meeting AFASS criteria) need to be identified and tested.

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study.

PubMed

Reiner, Anne S; Sisti, Julia; John, Esther M; Lynch, Charles F; Brooks, Jennifer D; Mellemkjær, Lene; Boice, John D; Knight, Julia A; Concannon, Patrick; Capanu, Marinela; Tischkowitz, Marc; Robson, Mark; Liang, Xiaolin; Woods, Meghan; Conti, David V; Duggan, David; Shore, Roy; Stram, Daniel O; Thomas, Duncan C; Malone, Kathleen E; Bernstein, Leslie; Bernstein, Jonine L

2018-05-20

Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious BRCA1/2 mutations. With the completion of WECARE II, updated risk estimates are reported. Additional analyses that exclude women negative for deleterious mutations in ATM, CHEK2*1100delC, and PALB2 were performed. Patients and Methods The WECARE Study is a population-based case-control study that compared 1,521 CBC cases with 2,212 individually matched unilateral breast cancer (UBC) controls. Participants were younger than age 55 years when diagnosed with a first invasive breast cancer between 1985 and 2008. Women were interviewed about breast cancer risk factors, including family history. A subset of women was screened for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2. Rate ratios (RRs) were estimated using multivariable conditional logistic regression. Cumulative absolute risks (ARs) were estimated by combining RRs from the WECARE Study and population-based SEER*Stat cancer incidence data. Results Women with any first-degree relative with breast cancer had a 10-year AR of 8.1% for CBC (95% CI, 6.7% to 9.8%). Risks also were increased if the relative was diagnosed at an age younger than 40 years (10-year AR, 13.5%; 95% CI, 8.8% to 20.8%) or with CBC (10-year AR, 14.1%; 95% CI, 9.5% to 20.7%). These risks are comparable with those seen in BRCA1/2 deleterious mutation carriers (10-year AR, 18.4%; 95% CI, 16.0% to 21.3%). In the subset of women who tested negative for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2, estimates were unchanged. Adjustment for known breast cancer single-nucleotide polymorphisms did not affect estimates. Conclusion Breast cancer family history confers a high CBC risk, even after excluding women with deleterious mutations. Clinicians are urged to use detailed family histories to guide treatment and future screening decisions for young women with breast cancer.

Towards mitigating the effect of sine-Gaussian noise transients on searches for gravitational waves from compact binary coalescences

NASA Astrophysics Data System (ADS)

Bose, Sukanta; Dhurandhar, Sanjeev; Gupta, Anuradha; Lundgren, Andrew

2016-12-01

Gravitational wave signals were recently detected directly by LIGO from the coalescences of two stellar mass black hole pairs. These detections have strengthened our long held belief that compact binary coalescences (CBCs) are the most promising gravitational wave detection prospects accessible to ground-based interferometric detectors. For detecting CBC signals, it is of vital importance to characterize and identify non-Gaussian and nonstationary noise in these detectors. In this work, we model two important classes of transient artifacts that contribute to this noise and adversely affect the detector sensitivity to CBC signals. One of them is the sine-Gaussian "glitch," characterized by a central frequency f0 and a quality factor Q and the other is the chirping sine-Gaussian glitch, which is characterized by f0, Q as well as a chirp parameter. We study the response that a bank of compact binary inspiral templates has to these two families of glitches when they are used to match filter data containing any of these glitches. Two important characteristics of this response are the distributions of the signal-to-noise ratio and the time lag (i.e., how long after the occurrence of a glitch the signal-to-noise ratio of a trigger arises from its matched filtering by a template peaks) of individual templates. We show how these distributions differ from those when the detector data has a real CBC signal instead of a glitch. We argue that these distinctions can be utilized to develop useful signal-artifact discriminators that add negligibly to the computational cost of a CBC search. Specifically, we show how the central frequency of a glitch can be used to set adaptive time windows around it so that any template trigger occurring in that window can be quarantined for further vetting of its supposed astrophysical nature. Second, we recommend focusing efforts on reducing the incidence of glitches with low central-frequency values because they create CBC triggers with the longest time lags. This work allows us to associate such triggers with the glitches that otherwise would have escaped attention.

Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel.

PubMed

Clancy, Cornelius J; Pappas, Peter G; Vazquez, Jose; Judson, Marc A; Kontoyiannis, Dimitrios P; Thompson, George R; Garey, Kevin W; Reboli, Annette; Greenberg, Richard N; Apewokin, Senu; Lyon, G Marshall; Ostrosky-Zeichner, Luis; Wu, Alan H B; Tobin, Ellis; Nguyen, M Hong; Caliendo, Angela M

2018-02-09

Blood cultures are approximately 50% sensitive for diagnosing invasive candidiasis. The T2Candida nanodiagnostic panel uses T2 magnetic resonance and a dedicated instrument to detect Candida directly within whole blood samples. Patients with Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, or Candida krusei candidemia were identified at 14 centers using diagnostic blood cultures (dBCs). Follow-up blood samples were collected concurrently for testing by T2Candida and companion cultures (cBCs). T2Candida results are reported qualitatively for C. albicans/C. tropicalis, C. glabrata/C. krusei, and C. parapsilosis. T2Candida and cBCs were positive if they detected a species present in the dBC. Median time between collection of dBC and T2Candida/cBC samples in 152 patients was 55.5 hours (range, 16.4-148.4). T2Candida and cBCs were positive in 45% (69/152) and 24% (36/152) of patients, respectively (P < .0001). T2Candida clinical sensitivity was 89%, as positive results were obtained in 32/36 patients with positive cBCs. Combined test results were both positive (T2+/cBC+), 21% (32/152); T2+/cBC-, 24% (37/152); T2-/cBC+, 3% (4/152); and T2-/cBC-, 52% (79/152). Prior antifungal therapy, neutropenia, and C. albicans candidemia were independently associated with T2Candida positivity and T2+/cBC- results (P values < .05). T2Candida was sensitive for diagnosing candidemia at the time of positive blood cultures. In patients receiving antifungal therapy, T2Candida identified bloodstream infections that were missed by cBCs. T2Candida may improve care by shortening times to Candida detection and species identification compared to blood cultures, retaining sensitivity during antifungal therapy and rendering active candidemia unlikely if results are negative. NCT01525095. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Evaluation of clinical pathology parameters in fecal PCR-positive or PCR-negative goats for Johne's disease.

PubMed

Bonelli, Francesca; Fratini, F; Turchi, B; Cantile, C; Ebani, V V; Colombani, G; Galiero, A; Sgorbini, M

2017-10-01

Johne's disease (JD) is an economically important infectious disease of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). This study evaluated the differences in various hematological and biochemical parameters between healthy goats and goats with JD. Forty goats were chosen randomly from a herd endemic for JD. A complete physical examination was performed. Blood and fresh fecal samples were collected from each goat. A complete blood cell (CBC) count and a protein electrophoresis were performed. Polymerase chain reaction (PCR) on fecal samples was performed in order to divide goats into two groups: group A "positive PCR on feces"; and group B "control (negative)." A Student's t test was performed for each parameter to verify differences between groups A vs B. Twenty goats were included in each group. Clinical signs likely related to JD were found in the history of 4/40 (10%) goats, while 36/40 (90%) goats were reported to be asymptomatic. CBC and electrophoresis values were within reference intervals in both groups. No differences were found for CBC parameters between the two groups. Values for alpha 1, beta, gamma globulins, and total protein (TP) were statistically higher in group A vs those in group B, while those for albumin and albumin/globulin (A/G) ratio were lower. An increase in TP, hypoalbuminemia, and hypergammaglobulinemia has been reported in group A, while no abnormalities were found concerning CBC. JD-positive goats seem to show earlier clinical pathological alternations than clinical signs. Protein electrophoresis may help the diagnosis of JD in asymptomatic goat herds, acting as an economical screening method.

Association of hematologic variables and castration status at the time of arrival at a research facility with the risk of bovine respiratory disease in beef calves.

PubMed

Richeson, John T; Pinedo, Pablo J; Kegley, Elizabeth B; Powell, Jeremy G; Gadberry, M Shane; Beck, Paul A; Falkenberg, Shollie M

2013-10-01

To determine the association of CBC variables and castration status at the time of arrival at a research facility with the risk of development of bovine respiratory disease (BRD). Retrospective cohort study. 1,179 crossbred beef bull (n = 588) and steer (591) calves included in 4 experiments at 2 University of Arkansas research facilities. Calves underwent processing and treatments in accordance with the experiment in which they were enrolled. Castration status and values of CBC variables were determined at the time of arrival at the facilities. Calves were monitored to detect signs of BRD during a 42-day period. The areas under the receiving operator characteristic curves for CBC variables with significant contrast test results ranged from 0.51 (neutrophil count) to 0.67 (eosinophil count), indicating they were limited predictors of BRD in calves. The only CBC variables that had significant associations with BRD in calves as determined via multivariable logistic regression analysis were eosinophil and RBC counts. The odds of BRD for bulls were 3.32 times the odds of BRD for steers. Results of this study indicated that low eosinophil and high RBC counts in blood samples may be useful for identification of calves with a high risk for development of BRD. Further research may be warranted to validate these variables for prediction of BRD in calves. Calves that were bulls at the time of arrival had a higher risk of BRD, versus calves that were steers at that time.

Experimental and Analytical Performance of a Dual Brayton Power Conversion System

NASA Technical Reports Server (NTRS)

Lavelle, Thomas A.; Hervol, David S.; Briggs, Maxwell; Owen, A. Karl

2009-01-01

The interactions between two closed Brayton cycle (CBC) power conversion units (PCU) which share a common gas inventory and heat source have been studied experimentally using the Dual Brayton Power Conversion System (DBPCS) and analytically using the Closed- Cycle System Simulation (CCSS) computer code. Selected operating modes include steady-state operation at equal and unequal shaft speeds and various start-up scenarios. Equal shaft speed steady-state tests were conducted for heater exit temperatures of 840 to 950 K and speeds of 50 to 90 krpm, providing a system performance map. Unequal shaft speed steady-state testing over the same operating conditions shows that the power produced by each Brayton is sensitive to the operating conditions of the other due to redistribution of gas inventory. Startup scenarios show that starting the engines one at a time can dramatically reduce the required motoring energy. Although the DBPCS is not considered a flight-like system, these insights, as well as the operational experience gained from operating and modeling this system provide valuable information for the future development of Brayton systems.

Performance evaluation of BC-3200 hematology analyzer in a university hospital.

PubMed

Peng, L; Bai, L; Nie, L; Wu, Z; Yan, C

2008-06-01

The BC-3200 automated hematology analyzer was evaluated and compared with the Beckman-Coulter AcT (Ac.T diff 2) 3-part differential hematology analyzer. The BC-3200 was evaluated according to guidelines published by the International Committee for Standardization in Hematology (ICSH), Clinical and Laboratory Standards Institute (CLSI), and Department of Food and Drug Administration (FDA). The results demonstrated no background, minimal carryover (<0.5%), and excellent linearity for hemoglobin (Hb) level, white blood cell (WBC), red blood cell (RBC), and platelet (PLT) counts (>0.998). Precision was generally acceptable for all complete blood count (CBC) parameters; coefficients of variation (CVs) were within the manufacturer's claims and CVs of CBC parameters, including WBC, RBC and PLT counts, Hb and mean corpuscular volume, were <6%. Correlation between the BC-3200 and Ac.T diff 2 was excellent (r > 0.98) for all major CBC parameters (WBC, RBC, and PLT counts and Hb). We conclude that the overall performance of the BC-3200 is excellent and compares well with that of the Coulter Ac.T diff 2.

[Conduct problems in a sample of institutionalized minors with previous mistreatment].

PubMed

Carrasco-Ortiz, M A; Rodríguez-Testal, J F; Hesse, B M

2001-06-01

The present study tries to analyse the maltreatment effects and the expected relation, according to the reviewed literature, with behaviour problems in a sample of children in residential care in a protection centre in Seville county (Spain). The sample was conformed by a group of maltreated subjects in a protection setting (n = 30) and two groups of equivalent comparison (n = 30 and n = 30). The first group was conformed by subjects living in a marginal area of Sevilla, similar to the origin setting of the study group, and the second group comes from a wealthy area of this city. The behaviour problems index CBC of Achenbach (1978; 1979; Achenbach & Edelbrock, 1983) was used. No significant differences between groups in the CBC total score was found. However, significant differences were found in the extemalising dimension and in the delinquency, somatic anxiety, somatic problems, and social withdrawal dimensions. Victims of corruption presented higher scores on the CBC total score, extemalising dimension, and delinquency. Young people, victims of child maltreatment and living in an institution, showed problems of withdrawal. Victims of corruption or emotional abuse presented more psychopathological problems.

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess

PubMed Central

Gsaller, Fabio; Hortschansky, Peter; Beattie, Sarah R; Klammer, Veronika; Tuppatsch, Katja; Lechner, Beatrix E; Rietzschel, Nicole; Werner, Ernst R; Vogan, Aaron A; Chung, Dawoon; Mühlenhoff, Ulrich; Kato, Masashi; Cramer, Robert A; Brakhage, Axel A; Haas, Hubertus

2014-01-01

Balance of physiological levels of iron is essential for every organism. In Aspergillus fumigatus and other fungal pathogens, the transcription factor HapX mediates adaptation to iron limitation and consequently virulence by repressing iron consumption and activating iron uptake. Here, we demonstrate that HapX is also essential for iron resistance via activating vacuolar iron storage. We identified HapX protein domains that are essential for HapX functions during either iron starvation or high-iron conditions. The evolutionary conservation of these domains indicates their wide-spread role in iron sensing. We further demonstrate that a HapX homodimer and the CCAAT-binding complex (CBC) cooperatively bind an evolutionary conserved DNA motif in a target promoter. The latter reveals the mode of discrimination between general CBC and specific HapX/CBC target genes. Collectively, our study uncovers a novel regulatory mechanism mediating both iron resistance and adaptation to iron starvation by the same transcription factor complex with activating and repressing functions depending on ambient iron availability. PMID:25092765

Removal of Mn, Fe, Ni and Cu Ions from Wastewater Using Cow Bone Charcoal

PubMed Central

Moreno, Juan Carlos; Gómez, Rigoberto; Giraldo, Liliana

2010-01-01

Cow bone charcoal (CBC) was synthesized and used for the removal of metals ions (manganese, iron, nickel and copper) from aqueous solutions. Two different adsorption models were used for analyzing the data. Adsorption capacities were determined: copper ions exhibit the greatest adsorption on cow bone charcoal because of their size and pH conditions. Adsorption capacity varies as a function of pH. Adsorption isotherms from aqueous solution of heavy metals on CBC were determined. Adsorption isotherms are consistent with Langmuir´s adsorption model. Adsorbent quantity and immersion enthalpy were studied.

Test beam demonstration of silicon microstrip modules with transverse momentum discrimination for the future CMS tracking detector

NASA Astrophysics Data System (ADS)

Adam, W.; Bergauer, T.; Brondolin, E.; Dragicevic, M.; Friedl, M.; Frühwirth, R.; Hoch, M.; Hrubec, J.; König, A.; Steininger, H.; Treberspurg, W.; Waltenberger, W.; Alderweireldt, S.; Beaumont, W.; Janssen, X.; Lauwers, J.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Beghin, D.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Luetic, J.; Maerschalk, T.; Marinov, A.; Postiau, N.; Randle-Conde, A.; Seva, T.; Vanlaer, P.; Vannerom, D.; Yonamine, R.; Wang, Q.; Yang, Y.; Zenoni, F.; Zhang, F.; Abu Zeid, S.; Blekman, F.; De Bruyn, I.; De Clercq, J.; D'Hondt, J.; Deroover, K.; Lowette, S.; Moortgat, S.; Moreels, L.; Python, Q.; Skovpen, K.; Van Mulders, P.; Van Parijs, I.; Bakhshiansohi, H.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; Delaere, C.; Delcourt, M.; De Visscher, S.; Francois, B.; Giammanco, A.; Jafari, A.; Cabrera Jamoulle, J.; De Favereau De Jeneret, J.; Komm, M.; Krintiras, G.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Michotte, D.; Musich, M.; Piotrzkowski, K.; Quertenmont, L.; Szilasi, N.; Vidal Marono, M.; Wertz, S.; Beliy, N.; Caebergs, T.; Daubie, E.; Hammad, G. H.; Härkönen, J.; Lampén, T.; Luukka, P.; Peltola, T.; Tuominen, E.; Tuovinen, E.; Eerola, P.; Baulieu, G.; Boudoul, G.; Caponetto, L.; Combaret, C.; Contardo, D.; Dupasquier, T.; Gallbit, G.; Lumb, N.; Mirabito, L.; Perries, S.; Vander Donckt, M.; Viret, S.; Agram, J.-L.; Andrea, J.; Bloch, D.; Bonnin, C.; Brom, J.-M.; Chabert, E.; Chanon, N.; Charles, L.; Conte, E.; Fontaine, J.-Ch.; Gross, L.; Hosselet, J.; Jansova, M.; Tromson, D.; Autermann, C.; Feld, L.; Karpinski, W.; Kiesel, K. M.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Pierschel, G.; Preuten, M.; Rauch, M.; Schael, S.; Schomakers, C.; Schulz, J.; Schwering, G.; Wlochal, M.; Zhukov, V.; Pistone, C.; Fluegge, G.; Kuensken, A.; Pooth, O.; Stahl, A.; Aldaya, M.; Asawatangtrakuldee, C.; Beernaert, K.; Bertsche, D.; Contreras-Campana, C.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Gallo, E.; Garay Garcia, J.; Hansen, K.; Haranko, M.; Harb, A.; Hauk, J.; Keaveney, J.; Kalogeropoulos, A.; Kleinwort, C.; Lohmann, W.; Mankel, R.; Maser, H.; Mittag, G.; Muhl, C.; Mussgiller, A.; Pitzl, D.; Reichelt, O.; Savitskyi, M.; Schuetze, P.; Walsh, R.; Zuber, A.; Biskop, H.; Buhmann, P.; Centis-Vignali, M.; Garutti, E.; Haller, J.; Hoffmann, M.; Klanner, R.; Matysek, M.; Perieanu, A.; Scharf, Ch.; Schleper, P.; Schmidt, A.; Schwandt, J.; Sonneveld, J.; Steinbrück, G.; Vormwald, B.; Wellhausen, J.; Abbas, M.; Amstutz, C.; Barvich, T.; Barth, Ch.; Boegelspacher, F.; De Boer, W.; Butz, E.; Casele, M.; Colombo, F.; Dierlamm, A.; Freund, B.; Hartmann, F.; Heindl, S.; Husemann, U.; Kornmeyer, A.; Kudella, S.; Muller, Th.; Printz, M.; Simonis, H. J.; Steck, P.; Weber, M.; Weiler, Th.; Anagnostou, G.; Asenov, P.; Assiouras, P.; Daskalakis, G.; Kyriakis, A.; Loukas, D.; Paspalaki, L.; Siklér, F.; Veszprémi, V.; Bhardwaj, A.; Dalal, R.; Jain, G.; Ranjan, K.; Dutta, S.; Chowdhury, S. Roy; Bakhshiansohl, H.; Behnamian, H.; Khakzad, M.; Naseri, M.; Cariola, P.; Creanza, D.; De Palma, M.; De Robertis, G.; Fiore, L.; Franco, M.; Loddo, F.; Sala, G.; Silvestris, L.; Maggi, G.; My, S.; Selvaggi, G.; Albergo, S.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Saizu, M. A.; Tricomi, A.; Tuve, C.; Barbagli, G.; Brianzi, M.; Ciaranfi, R.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Latino, G.; Lenzi, P.; Meschini, M.; Paoletti, S.; Russo, L.; Scarlini, E.; Sguazzoni, G.; Strom, D.; Viliani, L.; Ferro, F.; Lo Vetere, M.; Robutti, E.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Malvezzi, S.; Manzoni, R. A.; Menasce, D.; Moroni, L.; Pedrini, D.; Azzi, P.; Bacchetta, N.; Bisello, D.; Dall'Osso, M.; Pozzobon, N.; Tosi, M.; De Canio, F.; Gaioni, L.; Manghisoni, M.; Nodari, B.; Riceputi, E.; Re, V.; Traversi, G.; Comotti, D.; Ratti, L.; Alunni Solestizi, L.; Biasini, M.; Bilei, G. M.; Cecchi, C.; Checcucci, B.; Ciangottini, D.; Fanò, L.; Gentsos, C.; Ionica, M.; Leonardi, R.; Manoni, E.; Mantovani, G.; Marconi, S.; Mariani, V.; Menichelli, M.; Modak, A.; Morozzi, A.; Moscatelli, F.; Passeri, D.; Placidi, P.; Postolache, V.; Rossi, A.; Saha, A.; Santocchia, A.; Storchi, L.; Spiga, D.; Androsov, K.; Azzurri, P.; Arezzini, S.; Bagliesi, G.; Basti, A.; Boccali, T.; Borrello, L.; Bosi, F.; Castaldi, R.; Ciampa, A.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Magazzu, G.; Martini, L.; Mazzoni, E.; Messineo, A.; Moggi, A.; Morsani, F.; Palla, F.; Palmonari, F.; Raffaelli, F.; Rizzi, A.; Savoy-Navarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Bellan, R.; Costa, M.; Covarelli, R.; Da Rocha Rolo, M.; Demaria, N.; Rivetti, A.; Dellacasa, G.; Mazza, G.; Migliore, E.; Monteil, E.; Pacher, L.; Ravera, F.; Solano, A.; Fernandez, M.; Gomez, G.; Jaramillo Echeverria, R.; Moya, D.; Gonzalez Sanchez, F. J.; Vila, I.; Virto, A. L.; Abbaneo, D.; Ahmed, I.; Albert, E.; Auzinger, G.; Berruti, G.; Bianchi, G.; Blanchot, G.; Bonnaud, J.; Caratelli, A.; Ceresa, D.; Christiansen, J.; Cichy, K.; Daguin, J.; D'Auria, A.; Detraz, S.; Deyrail, D.; Dondelewski, O.; Faccio, F.; Frank, N.; Gadek, T.; Gill, K.; Honma, A.; Hugo, G.; Jara Casas, L. M.; Kaplon, J.; Kornmayer, A.; Kottelat, L.; Kovacs, M.; Krammer, M.; Lenoir, P.; Mannelli, M.; Marchioro, A.; Marconi, S.; Mersi, S.; Martina, S.; Michelis, S.; Moll, M.; Onnela, A.; Orfanelli, S.; Pavis, S.; Peisert, A.; Pernot, J.-F.; Petagna, P.; Petrucciani, G.; Postema, H.; Rose, P.; Tropea, P.; Troska, J.; Tsirou, A.; Vasey, F.; Vichoudis, P.; Verlaat, B.; Zwalinski, L.; Bachmair, F.; Becker, R.; di Calafiori, D.; Casal, B.; Berger, P.; Djambazov, L.; Donega, M.; Grab, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marionneau, M.; Martinez Ruiz del Arbol, P.; Masciovecchio, M.; Meinhard, M.; Perozzi, L.; Roeser, U.; Starodumov, A.; Tavolaro, V.; Wallny, R.; Zhu, D.; Amsler, C.; Bösiger, K.; Caminada, L.; Canelli, F.; Chiochia, V.; de Cosa, A.; Galloni, C.; Hreus, T.; Kilminster, B.; Lange, C.; Maier, R.; Ngadiuba, J.; Pinna, D.; Robmann, P.; Taroni, S.; Yang, Y.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Kaestli, H.-C.; Kotlinski, D.; Langenegger, U.; Meier, B.; Rohe, T.; Streuli, S.; Chen, P.-H.; Dietz, C.; Grundler, U.; Hou, W.-S.; Lu, R.-S.; Moya, M.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Jacob, J.; Seif El Nasr-Storey, S.; Cole, J.; Hoad, C.; Hobson, P.; Morton, A.; Reid, I. D.; Auzinger, G.; Bainbridge, R.; Dauncey, P.; Fulcher, J.; Hall, G.; James, T.; Magnan, A.-M.; Pesaresi, M.; Raymond, D. M.; Uchida, K.; Braga, D.; Coughlan, J. A.; Harder, K.; Jones, L.; Ilic, J.; Murray, P.; Prydderch, M.; Tomalin, I. R.; Garabedian, A.; Heintz, U.; Narain, M.; Nelson, J.; Sagir, S.; Speer, T.; Swanson, J.; Tersegno, D.; Watson-Daniels, J.; Chertok, M.; Conway, J.; Conway, R.; Flores, C.; Lander, R.; Pellett, D.; Ricci-Tam, F.; Squires, M.; Thomson, J.; Yohay, R.; Burt, K.; Ellison, J.; Hanson, G.; Olmedo, M.; Si, W.; Yates, B. R.; Gerosa, R.; Sharma, V.; Vartak, A.; Yagil, A.; Zevi Della Porta, G.; Dutta, V.; Gouskos, L.; Incandela, J.; Kyre, S.; Mullin, S.; Qu, H.; White, D.; Dominguez, A.; Bartek, R.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Leontsinis, S.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Apresyan, A.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chramowicz, J.; Christian, D.; Cooper, W. E.; Deptuch, G.; Derylo, G.; Gingu, C.; Grünendahl, S.; Hasegawa, S.; Hoff, J.; Howell, J.; Hrycyk, M.; Jindariani, S.; Johnson, M.; Kahlid, F.; Lei, C. M.; Lipton, R.; Lopes De Sá, R.; Liu, T.; Los, S.; Matulik, M.; Merkel, P.; Nahn, S.; Prosser, A.; Rivera, R.; Schneider, B.; Sellberg, G.; Shenai, A.; Spiegel, L.; Tran, N.; Uplegger, L.; Voirin, E.; Berry, D. R.; Chen, X.; Ennesser, L.; Evdokimov, A.; Evdokimov, O.; Gerber, C. E.; Hofman, D. J.; Makauda, S.; Mills, C.; Sandoval Gonzalez, I. D.; Alimena, J.; Antonelli, L. J.; Francis, B.; Hart, A.; Hill, C. S.; Parashar, N.; Stupak, J.; Bortoletto, D.; Bubna, M.; Hinton, N.; Jones, M.; Miller, D. H.; Shi, X.; Tan, P.; Baringer, P.; Bean, A.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Wilson, G.; Ivanov, A.; Mendis, R.; Mitchell, T.; Skhirtladze, N.; Taylor, R.; Anderson, I.; Fehling, D.; Gritsan, A.; Maksimovic, P.; Martin, C.; Nash, K.; Osherson, M.; Swartz, M.; Xiao, M.; Acosta, J. G.; Cremaldi, L. M.; Oliveros, S.; Perera, L.; Summers, D.; Bloom, K.; Claes, D. R.; Fangmeier, C.; Gonzalez Suarez, R.; Monroy, J.; Siado, J.; Hahn, K.; Sevova, S.; Sung, K.; Trovato, M.; Bartz, E.; Gershtein, Y.; Halkiadakis, E.; Kyriacou, S.; Lath, A.; Nash, K.; Osherson, M.; Schnetzer, S.; Stone, R.; Walker, M.; Malik, S.; Norberg, S.; Ramirez Vargas, J. E.; Alyari, M.; Dolen, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Kharchilava, A.; Nguyen, D.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; McDermott, K.; Mirman, N.; Rinkevicius, A.; Ryd, A.; Salvati, E.; Skinnari, L.; Soffi, L.; Tao, Z.; Thom, J.; Tucker, J.; Zientek, M.; Akgün, B.; Ecklund, K. M.; Kilpatrick, M.; Nussbaum, T.; Zabel, J.; Betchart, B.; Covarelli, R.; Demina, R.; Hindrichs, O.; Petrillo, G.; Eusebi, R.; Patel, R.; Perloff, A.; Ulmer, K. A.; Delannoy, A. G.; D'Angelo, P.; Johns, W.

2018-03-01

A new CMS Tracker is under development for operation at the High Luminosity LHC from 2026 onwards. It includes an outer tracker based on dedicated modules that will reconstruct short track segments, called stubs, using spatially coincident clusters in two closely spaced silicon sensor layers. These modules allow the rejection of low transverse momentum track hits and reduce the data volume before transmission to the first level trigger. The inclusion of tracking information in the trigger decision is essential to limit the first level trigger accept rate. A customized front-end readout chip, the CMS Binary Chip (CBC), containing stub finding logic has been designed for this purpose. A prototype module, equipped with the CBC chip, has been constructed and operated for the first time in a 4 GeemVem/emc positron beam at DESY. The behaviour of the stub finding was studied for different angles of beam incidence on a module, which allows an estimate of the sensitivity to transverse momentum within the future CMS detector. A sharp transverse momentum threshold around 2 emVem/emc was demonstrated, which meets the requirement to reject a large fraction of low momentum tracks present in the LHC environment on-detector. This is the first realistic demonstration of a silicon tracking module that is able to select data, based on the particle's transverse momentum, for use in a first level trigger at the LHC . The results from this test are described here.

Error-correcting pairs for a public-key cryptosystem

NASA Astrophysics Data System (ADS)

Pellikaan, Ruud; Márquez-Corbella, Irene

2017-06-01

Code-based Cryptography (CBC) is a powerful and promising alternative for quantum resistant cryptography. Indeed, together with lattice-based cryptography, multivariate cryptography and hash-based cryptography are the principal available techniques for post-quantum cryptography. CBC was first introduced by McEliece where he designed one of the most efficient Public-Key encryption schemes with exceptionally strong security guarantees and other desirable properties that still resist to attacks based on Quantum Fourier Transform and Amplitude Amplification. The original proposal, which remains unbroken, was based on binary Goppa codes. Later, several families of codes have been proposed in order to reduce the key size. Some of these alternatives have already been broken. One of the main requirements of a code-based cryptosystem is having high performance t-bounded decoding algorithms which is achieved in the case the code has a t-error-correcting pair (ECP). Indeed, those McEliece schemes that use GRS codes, BCH, Goppa and algebraic geometry codes are in fact using an error-correcting pair as a secret key. That is, the security of these Public-Key Cryptosystems is not only based on the inherent intractability of bounded distance decoding but also on the assumption that it is difficult to retrieve efficiently an error-correcting pair. In this paper, the class of codes with a t-ECP is proposed for the McEliece cryptosystem. Moreover, we study the hardness of distinguishing arbitrary codes from those having a t-error correcting pair.

Effects of biochars derived from chicken manure and rape straw on speciation and phytoavailability of Cd to maize in artificially contaminated loess soil.

PubMed

Zhao, Baowei; Xu, Renzhi; Ma, Fengfeng; Li, Yewei; Wang, Lu

2016-12-15

While biochar can reduce the bioavailability of heavy metals in acidic soils and reduce their risk of entering the food chain, conditions for alkaline soils such as loess soils with high pH values, high carbonate content and low organic matter content remain unclear. Pot experiments were conducted to assess the effects of four rates (1%, 5%, 10%, and 15% w/w) of biochars prepared at 600 °C from chicken manure and rape straw (CBC and RBC) on soil properties, Cd speciation and phytoavailability, and plant growth in Cd contaminated (20 mg kg -1 ) light sierozem using maize (Zea mays L.) as an indicator plant. Biochar additions significantly (P < 0.05) increased soil pH values, cation exchange capacity (CEC) and soil organic matter (OM). The results showed that Cd speciation turned somewhat into stable state as biochar application increased. When CBC and RBC was applied at the rate of 15%, the content of acid-extractable Cd decreased only by 16.3% and 11.64%, respectively. The uptake of Cd by maize shoots scarcely decreased with CBC and RBC amendment at the rate of 1% and 5%, respectively. Although it seemed that additions of more than 5% CBC or RBC significantly (P < 0.05) reduced Cd contents in maize shoots, maize growth was largely inhibited due to the high value of soil pH. These results could provide different implications for immobilization remediation of loess soils (e.g., light sierozem) contaminated with Cd. Copyright © 2016 Elsevier Ltd. All rights reserved.

Establishment of reference intervals for complete blood count parameters during normal pregnancy in Beijing.

PubMed

Li, Aiwei; Yang, Shuo; Zhang, Jie; Qiao, Rui

2017-11-01

To observe the changes of complete blood count (CBC) parameters during pregnancy and establish appropriate reference intervals for healthy pregnant women. Healthy pregnant women took the blood tests at all trimesters. All blood samples were processed on Sysmex XE-2100. The following CBC parameters were analyzed: red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), white blood cell count (WBC), and leukocyte differential count. Reference intervals were established using the 2.5th and 97.5th percentile of the distribution. Complete blood count parameters showed dynamic changes during trimesters. RBC, Hb, Hct declined at trimester 1, reaching their lowest point at trimester 2, and began to rise again at trimester 3. WBC, neutrophil count (Neut), monocyte count (MONO), RDW, and PDW went up from trimester 1 to trimester 3. On the contrary, MCHC, lymphocyte count (LYMPH), PLT, and MPV gradually descended during pregnancy. There were statistical significances in all CBC parameters between pregnant women and normal women, regardless of the trimesters (P<.001). The median obtained were (normal vs pregnancy) as follows: RBC 4.50 vs 3.94×10 12 /L, Hb 137 vs 120 g/L, WBC 5.71 vs 9.06×10 9 /L, LYMPH% 32.2 vs 18.0, Neut% 58.7 vs 75.0, and PLT 251 vs 202×10 9 /L. The changes of CBC parameters during pregnancy are described, and reference intervals for Beijing pregnant women are demonstrated in this study. © 2017 Wiley Periodicals, Inc.

Perceptions of Acute Malnutrition and Its Management in Infants Under 6 Months of Age: A Qualitative Study in Rural Bangladesh

PubMed Central

Arafat, Yasir; Islam, M Munirul; Connell, Nicki; Mothabbir, Golam; McGrath, Marie; Berkley, James A; Ahmed, Tahmeed; Kerac, Marko

2018-01-01

Background: World Health Organization guidelines advise community-based care (CBC) for “uncomplicated” severe acute malnutrition (SAM) infants <6 months old (u6m), whereas current national protocols refer to inpatient care. Our aim was to inform and shape future management strategies by understanding caregivers’ and different stakeholders’ perceptions on malnutrition among infants u6m on barriers/facilitators to future CBC. Methods: The methods used in this study are as follows: in-depth interviews and focus group discussions (FGDs) in southern Bangladesh, thematic analysis of transcripts, and sample size by data saturation. Results: We conducted 5 FGDs with 29 caregivers, 4 with 29 health care workers, 4 key informant interviews each with community leaders and health supervisors. Five themes emerged. 1) Identification of SAM infants and care-seeking behavior: malnutrition was not noticed until severe, caregivers focused on clinical symptoms. Both allopathic and traditional healers were consulted. (2) Perceived causes of infant malnutrition: underlying illness, poor feeding practices, poverty, and local superstitions. (3) Views and preferences on treatment: hospitals and doctors were perceived as offering the best treatment, health care workers were also important, and respondents highlighted the need care of the caregiver/mother along with the infant. (4) Perceived benefits and risks of CBC: lower cost and greater accessibility were appreciated but worried about quality. (5) Community networks: wider family and social support networks were considered important aspects of care. Conclusions: There is considerable potential for CBC but needs to be better and earlier identification of at-risk infants, strengthening of health systems to avoid community options being perceived as “second best,” engagement with families and communities to tackle “upstream” determinants of SAM, and care for mother-infant pairs. PMID:29760577

Fire history and climate characteristics during the last millennium of the Great Hinggan Mountains at the monsoon margin in northeastern China

NASA Astrophysics Data System (ADS)

Gao, Chuanyu; He, Jiabao; Zhang, Yan; Cong, Jinxin; Han, Dongxue; Wang, Guoping

2018-03-01

The northeastern region of China, at the limit of the summer monsoon, is characterized by the presence of mountains that influenced by the Asian summer monsoon on one side and the westerlies on the other; however, few studies have compared the environmental characteristics on the two sides of these mountains. In this study, two peatland cores from the western and eastern sides of the Great Hinggan Mountains were investigated to better understand the climatic and environmental conditions and the measurements of black carbon (BC) and δ13C-BC were used to reconstruct the fire history and environmental characteristics during the last millennium. Our results showed that the variations in the δ13C-BC values are more sensitive to climate changes than the BC fluxes, and the climate forcing mechanisms differed between the two sides of the mountains. Lower δ13C-BC values around 500 cal yr BP on the western side of the mountains indicated climate conditions were wetter than that on the eastern side, and were influenced by low sea surface temperatures in the North Atlantic Ocean. The region east of the mountains was mainly influenced by the strong Asian summer monsoon, and the decreasing of δ13C-BC values indicated climate conditions became wetter from 250 cal yr BP to the present and were wetter than that on the western side after 150 cal yr BP. Moreover, when one of these two forcing factors weakened and the other strengthened (e.g. from 400 to 150 cal yr BP), climate conditions in these two sides were similar.

Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment.

PubMed

Oláh, Attila; Markovics, Arnold; Szabó-Papp, Judit; Szabó, Pálma Tímea; Stott, Colin; Zouboulis, Christos C; Bíró, Tamás

2016-09-01

Acne is a common skin disease characterized by elevated sebum production and inflammation of the sebaceous glands. We have previously shown that a non-psychotropic phytocannabinoid ((-)-cannabidiol [CBD]) exerted complex anti-acne effects by normalizing 'pro-acne agents'-induced excessive sebaceous lipid production, reducing proliferation and alleviating inflammation in human SZ95 sebocytes. Therefore, in this study we aimed to explore the putative anti-acne effects of further non-psychotropic phytocannabinoids ((-)-cannabichromene [CBC], (-)-cannabidivarin [CBDV], (-)-cannabigerol [CBG], (-)-cannabigerovarin [CBGV] and (-)-Δ(9) -tetrahydrocannabivarin [THCV]). Viability and proliferation of human SZ95 sebocytes were investigated by MTT and CyQUANT assays; cell death and lipid synthesis were monitored by DilC1 (5)-SYTOX Green labelling and Nile Red staining, respectively. Inflammatory responses were investigated by monitoring expressions of selected cytokines upon lipopolysaccharide treatment (RT-qPCR, ELISA). Up to 10 μm, the phytocannabinoids only negligibly altered the viability of the sebocytes, whereas high doses (≥50 μm) induced apoptosis. Interestingly, basal sebaceous lipid synthesis was differentially modulated by the substances: CBC and THCV suppressed it, and CBDV had only minor effects, whereas CBG and CBGV increased it. Importantly, CBC, CBDV and THCV significantly reduced arachidonic acid (AA)-induced 'acne-like' lipogenesis. Moreover, THCV suppressed proliferation, and all phytocannabinoids exerted remarkable anti-inflammatory actions. Our data suggest that CBG and CBGV may have potential in the treatment of dry-skin syndrome, whereas CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agents. Moreover, based on their remarkable anti-inflammatory actions, phytocannabinoids could be efficient, yet safe novel tools in the management of cutaneous inflammations. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure

PubMed Central

Pügge, Carolin; Mediratta, Jai; Schiller, Alicia M.; Del Rio, Rodrigo; Zucker, Irving H.; Schultz, Harold D.

2015-01-01

In chronic heart failure (CHF), carotid body chemoreceptor (CBC) activity is increased and contributes to increased tonic and hypoxia-evoked elevation in renal sympathetic nerve activity (RSNA). Elevated RSNA and reduced renal perfusion may contribute to development of the cardio-renal syndrome in CHF. Exercise training (EXT) has been shown to abrogate CBC-mediated increases in RSNA in experimental heart failure; however, the effect of EXT on CBC control of renal blood flow (RBF) is undetermined. We hypothesized that CBCs contribute to tonic reductions in RBF in CHF, that stimulation of the CBC with hypoxia would result in exaggerated reductions in RBF, and that these responses would be attenuated with EXT. RBF was measured in CHF-sedentary (SED), CHF-EXT, CHF-carotid body denervation (CBD), and CHF-renal denervation (RDNX) groups. We measured RBF at rest and in response to hypoxia (FiO2 10%). All animals exhibited similar reductions in ejection fraction and fractional shortening as well as increases in ventricular systolic and diastolic volumes. Resting RBF was lower in CHF-SED (29 ± 2 ml/min) than in CHF-EXT animals (46 ± 2 ml/min, P < 0.05) or in CHF-CBD animals (42 ± 6 ml/min, P < 0.05). In CHF-SED, RBF decreased during hypoxia, and this was prevented in CHF-EXT animals. Both CBD and RDNX abolished the RBF response to hypoxia in CHF. Mean arterial pressure increased in response to hypoxia in CHF-SED, but was prevented by EXT, CBD, and RDNX. EXT is effective in attenuating chemoreflex-mediated tonic and hypoxia-evoked reductions in RBF in CHF. PMID:26001414

Cross-border cooperation potential in fostering redevelopment of degraded border areas - a case study approach.

NASA Astrophysics Data System (ADS)

Alexandre Castanho, Rui; Ramírez, Beatriz; Loures, Luis; Fernández-Pozo, Luis; Cabezas, José

2017-04-01

Border interactions have reached unprecedented levels in recent decades, not only due to their potential for territorial integration but also considering their role in supranational processes, such as landscape reclamation, infrastructure development and land use planning on European territory. In this scenario, successful examples related to the redevelopment of degraded areas have been showing positive impacts at several levels, such as the social, economic, environmental and aesthetic ones which have ultimately related this process, positively, to sustainability issues. However, concerning to border areas, and due to their inherent legislative and bureaucratic conflicts, the intervention in these areas is more complex. Still, and taking into account previously developed projects and strategies of cross-border cooperation (CBC) in European territory it is possible to identified that the definition of common master plans and common objectives are critical issues to achieve the desired territorial success. Additionally, recent studies have put forward some noteworthy ideas highlighting that it is possible to establish a positive correlation between CBC processes and an increasing redevelopment of degraded border areas, with special focus on the reclamation of derelict landscapes fostering soil reuse and redevelopment. The present research, throughout case study analysis at the Mediterranean level - considering case studies from Portugal, Spain, Monaco and Italy - which presents specific data on border landscape redevelopment, enables us to conclude that CBC processes have a positive influence on the potential redevelopment of degraded border areas, considering not only urban but also rural land. Furthermore, this paper presents data obtained through a public participation process which highlights that these areas present a greater potential for landscape reclamation, fostering resource sustainability and sustainable growth. Keywords: Spatial planning; Land degradation; Redevelopment; Cross-border cooperation (CBC); Land use.

Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin β

PubMed Central

Sato, Hanae; Maquat, Lynne E.

2009-01-01

Mammalian mRNAs lose and acquire proteins throughout their life span while undergoing processing, transport, translation, and decay. How translation affects messenger RNA (mRNA)–protein interactions is largely unknown. The pioneer round of translation uses newly synthesized mRNA that is bound by cap-binding protein 80 (CBP80)–CBP20 (also known as the cap-binding complex [CBC]) at the cap, poly(A)-binding protein N1 (PABPN1) and PABPC1 at the poly(A) tail, and, provided biogenesis involves pre-mRNA splicing, exon junction complexes (EJCs) at exon–exon junctions. Subsequent rounds of translation engage mRNA that is bound by eukaryotic translation initiation factor 4E (eIF4E) at the cap and PABPC1 at the poly(A) tail, but that lacks detectable EJCs and PABPN1. Using the level of intracellular iron to regulate the translation of specific mRNAs, we show that translation promotes not only removal of EJC constituents, including the eIF4AIII anchor, but also replacement of PABPN1 by PABPC1. Remarkably, translation does not affect replacement of CBC by eIF4E. Instead, replacement of CBC by eIF4E is promoted by importin β (IMPβ): Inhibiting the binding of IMPβ to the complex of CBC–IMPα at an mRNA cap using the IMPα IBB (IMPβ-binding) domain or a RAN variant increases the amount of CBC-bound mRNA and decreases the amount of eIF4E-bound mRNA. Our studies uncover a previously unappreciated role for IMPβ and a novel paradigm for how newly synthesized messenger ribonucleoproteins (mRNPs) are matured. PMID:19884259

Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure.

PubMed

Marcus, Noah J; Pügge, Carolin; Mediratta, Jai; Schiller, Alicia M; Del Rio, Rodrigo; Zucker, Irving H; Schultz, Harold D

2015-07-15

In chronic heart failure (CHF), carotid body chemoreceptor (CBC) activity is increased and contributes to increased tonic and hypoxia-evoked elevation in renal sympathetic nerve activity (RSNA). Elevated RSNA and reduced renal perfusion may contribute to development of the cardio-renal syndrome in CHF. Exercise training (EXT) has been shown to abrogate CBC-mediated increases in RSNA in experimental heart failure; however, the effect of EXT on CBC control of renal blood flow (RBF) is undetermined. We hypothesized that CBCs contribute to tonic reductions in RBF in CHF, that stimulation of the CBC with hypoxia would result in exaggerated reductions in RBF, and that these responses would be attenuated with EXT. RBF was measured in CHF-sedentary (SED), CHF-EXT, CHF-carotid body denervation (CBD), and CHF-renal denervation (RDNX) groups. We measured RBF at rest and in response to hypoxia (FiO2 10%). All animals exhibited similar reductions in ejection fraction and fractional shortening as well as increases in ventricular systolic and diastolic volumes. Resting RBF was lower in CHF-SED (29 ± 2 ml/min) than in CHF-EXT animals (46 ± 2 ml/min, P < 0.05) or in CHF-CBD animals (42 ± 6 ml/min, P < 0.05). In CHF-SED, RBF decreased during hypoxia, and this was prevented in CHF-EXT animals. Both CBD and RDNX abolished the RBF response to hypoxia in CHF. Mean arterial pressure increased in response to hypoxia in CHF-SED, but was prevented by EXT, CBD, and RDNX. EXT is effective in attenuating chemoreflex-mediated tonic and hypoxia-evoked reductions in RBF in CHF. Copyright © 2015 the American Physiological Society.

Evaluation of the impact of a total automation system in a large core laboratory on turnaround time.

PubMed

Lou, Amy H; Elnenaei, Manal O; Sadek, Irene; Thompson, Shauna; Crocker, Bryan D; Nassar, Bassam

2016-11-01

Growing financial and workload pressures on laboratories coupled with user demands for faster turnaround time (TAT) has steered the implementation of total laboratory automation (TLA). The current study evaluates the impact of a complex TLA on core laboratory efficiency through the analysis of the In-lab to Report TAT (IR-TAT) for five representative tests based on the different requested priorities. Mean, median and outlier percentages (OP) for IR-TAT were determined following TLA implementation and where possible, compared to the pre-TLA era. The shortest mean IR-TAT via the priority lanes of the TLA was 22min for Complete Blood Count (CBC), followed by 34min, 39min and 40min for Prothrombin time (PT), urea and potassium testing respectively. The mean IR-TAT for STAT CBC loaded directly on to the analyzers was 5min shorter than that processed via the TLA. The mean IR-TATs for both STAT potassium and urea via offline centrifugation were comparable to that processed by the TLA. The longest mean IR-TAT via regular lanes of the TLA was 62min for Thyroid-Stimulating Hormone (TSH) while the shortest was 17min for CBC. All parameters for IR-TAT for CBC and PT tests decreased significantly post- TLA across all requested priorities in particular the outlier percentage (OP) at 30 and 60min. TLA helps to efficiently manage substantial volumes of samples across all requested priorities. Manual processing for small STAT volumes, at both the initial centrifugation stage and front loading directly on to analyzers, is however likely to yield the shortest IR-TAT. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

SEM/EDS analysis and characterization of gunshot residues from Brazilian lead-free ammunition.

PubMed

Martiny, Andrea; Campos, Andrea P C; Sader, Marcia S; Pinto, André L

2008-05-02

The exposition to heavy metal-rich airborne due to fire practicing has forced to the development of heavy metal-free environmental ammunition primers all over the world. Here we characterize the GSR elements present in the Brazilian lead-free ammunition produced by Companhia Brasileira de Cartuchos (CBC) and commercialized by MagTech in the U.S. and Europe under the name CleanRange centerfire cartridges. Both first and second generations of CleanRange in calibers 9 mm Luger, .40 S&W, .380 AUTO and .38 SPL were analyzed and compared to regular Brazilian CBC ammunition by scanning electron microscopy/energy dispersive spectroscopy. Differences in composition and morphology of GSR particles from the two generations of CleanRange were observed. The first generation ammunition (found in Europe) presented spherical particles, being strontium the only unique element detected. The second generation (found in the U.S.) produced irregular particles composed mostly by potassium, aluminum, silicon and calcium. We can conclude that identification of GSR derived from CBC second generation lead-free ammunition in suspects' hands may be impossible without the addition of a distinct metallic taggant in the primer composition by the manufacturer.

The effects of psychotherapy on behavior problems of sexually abused deaf children.

PubMed

Sullivan, P M; Scanlan, J M; Brookhouser, P E; Schulte, L E; Knutson, J F

1992-01-01

This study assessed the effectiveness of a broad based psychotherapeutic intervention with a sample of 72 children sexually abused at a residential school for the deaf. An untreated comparison group emerged when about half of their parents refused the offer for psychotherapy provided by the school. Treated and untreated children were randomly assigned to two assessment groups: those who participated in a pretreatment assessment and those who did not. Houseparents at the residential school used the Child Behavior Checklist (CBC) to rate the pretreatment assessment children before treatment and all 72 children one year after the implementation of psychotherapy. Children receiving therapy had significantly fewer behavior problems than children not receiving therapy. There was a differential response to therapy on the basis of sex. Boys receiving therapy had significantly lower scores on the following CBC scales than the no treatment group: Total, Internal, External, Somatic, Uncommunicative, Immature, Hostile, Delinquent, Aggressive, and Hyperactive. There were no differences on the Schizoid and Obsessive scales. Girls receiving therapy had significantly lower scores than the no treatment group on the following CBC scales: Total, External, Depressed, Aggressive, and Cruel. There were no differences on the Internal, Anxious, Schizoid, Immature, Somatic, and Delinquent scales.

Adsorption of heavy metals from aqueous solution by UV-mutant Bacillus subtilis loaded on biochars derived from different stock materials.

PubMed

Wang, Ting; Sun, Hongwen; Ren, Xinhao; Li, Bing; Mao, Hongjun

2018-02-01

Two kinds of biochars, one derived from corn straw (CBC) and one from pig manure (PBC), were used as the carriers of a bacterium (B38) to adsorb heavy metals in solution. CBC exhibited high affinity to Hg(II), while PBC showed large adsorption capacity of Pb(II). After loading with B38, the sorption capacity of the co-sorbents were enhanced for Pb(II), but weakened for Hg(II). In a binary system, the overall adsorption capacity to Hg-Pb (CBC+B38, 136.7mg/g; PBC+B38, 181.3mg/g) on co-sorbents was equal to the sum of the single-component values for Hg(II) and Pb(II). Electrostatic interactions and precipitation are the major mechanisms in the adsorption of Hg(II). In contrast, cation-π interactions and precipitation were involved in the sorption process of Pb(II). Moreover, the sorption sites of Hg(II) and Pb(II) partially overlapped on the biochar surface, but were different on co-sorbents. Hence, the co-sorbents have an advantage over the biochar alone in the removal of heavy metal mixtures. Copyright © 2017 Elsevier Inc. All rights reserved.

Parker Solar Probe: Delta IV Heavy Second-stage and Port CBC Arrival, Offload, and Transport

NASA Image and Video Library

2017-08-26

The United Launch Alliance Mariner arrives at Port Canaveral's Army Warf carrying the third Delta IV Heavy common booster core and second stage for NASA's upcoming Parker Solar Probe spacecraft. The flight hardware is offloaded and transported to the Horizontal Integration Facility (HIF) at Cape Canaveral Air Force Station for preflight processing. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

Electronegativity identification of novel superhard materials.

PubMed

Li, Keyan; Wang, Xingtao; Zhang, Fangfang; Xue, Dongfeng

2008-06-13

We show that electronegativity can be used to effectively identify the hardness of crystal materials on the basis of a new microscopic model for hardness. Bond electronegativity is proposed to characterize the electron-holding energy of a bond, which is the intrinsic origin of hardness. Applying this model to c-BC(2)N materials, we confirm the proper bond composition of the experimentally observed phase of c-BC(2)N, in which the bond ratio N(C-C):N(B-N):N(B-C):N(C-N) is 3:3:1:1. A number of bonds that can or cannot form a superhard material are qualitatively distinguished, which enables us to explore novel superhard materials by screening possible elemental combinations.

The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study

PubMed Central

Georges, John; Sharp, Matthew H.; Lowery, Ryan P.; Wilson, Jacob M.; Purpura, Martin; Hornberger, Troy A.; Harding, Flint; Johnson, James H.; Peele, David M.

2018-01-01

Introduction Krill oil supplementation has been shown to improve postexercise immune function; however, its effect on muscle hypertrophy is currently unknown. Therefore, the aim of present study was to investigate the ability of krill oil to stimulate mTOR signaling and its ability to augment resistance training-induced changes in body composition and performance. Methods C2C12 myoblasts cells were stimulated with krill oil or soy-derived phosphatidylcholine (S-PC), and then, the ratio of P-p70-389 to total p70 was used as readout for mTOR signaling. In double-blind, placebo-controlled study, resistance trained subjects consumed either 3 g krill oil daily or placebo, and each took part in an 8-week periodized resistance training program. Body composition, maximal strength, peak power, and rate of perceived recovery were assessed collectively at the end of weeks 0 and 8. In addition, safety parameters (comprehensive metabolic panel (CMP), complete blood count (CBC), and urine analysis (UA)) and cognitive performance were measured pre- and posttesting. Results Krill oil significantly stimulated mTOR signaling in comparison to S-PC and control. No differences for markers on the CMP, CBC, or UA were observed. Krill oil significantly increased lean body mass from baseline (p=0.021, 1.4 kg, +2.1%); however, there were no statistically significant differences between groups for any measures taken. Conclusion Krill oil activates mTOR signaling. Krill oil supplementation in athletes is safe, and its effect on resistance exercise deserves further research. PMID:29854443

Evaluating compliance with institutional preoperative testing guidelines for minimal-risk patients undergoing elective surgery.

PubMed

Siriussawakul, Arunotai; Nimmannit, Akarin; Rattana-arpa, Sirirat; Chatrattanakulchai, Siritda; Saengtawan, Puttachard; Wangdee, Aungsumat

2013-01-01

Few investigations preoperatively are important for low-risk patients. This study was designed to determine the level of compliance with preoperative investigation guidelines for ASA I patients undergoing elective surgery. Secondary objectives included the following: to identify common inappropriate investigations, to evaluate the impact of abnormal testing on patient management, to determine factors affecting noncompliant tests, and to estimate unnecessary expenditure. This retrospective study was conducted on adult patients over a one-year period. The institute's guidelines recommend tests according to the patients' age groups: a complete blood count (CBC) for those patients aged 18-45; CBC, chest radiograph (CXR) and electrocardiography (ECG) for those aged 46-60; and CBC, CXR, ECG, electrolytes, blood glucose, blood urea nitrogen (BUN), and creatinine (Cr) for patients aged 61-65. The medical records of 1,496 patients were reviewed. Compliant testing was found in only 12.1% (95% CI, 10.5-13.9). BUN and Cr testings were the most frequently overprescribed tests. Overinvestigations tended to be performed on major surgery and younger patients. Overall, overinvestigation incurred an estimated cost of US 200,000 dollars during the study period. The need to utilize the institution's preoperative guidelines should be emphasized in order to decrease unnecessary testing and the consequential financial burden.

Preparation of Ceramic-Bonded Carbon Block for Blast Furnace

NASA Astrophysics Data System (ADS)

Li, Yiwei; Li, Yawei; Sang, Shaobai; Chen, Xilai; Zhao, Lei; Li, Yuanbing; Li, Shujing

2014-01-01

Traditional carbon blocks for blast furnaces are mainly produced with electrically calcined anthracite owing to its good hot metal corrosion resistance. However, this kind of material shows low thermal conductivity and does not meet the demands for cooling of the hearth and the bottom of blast furnaces. In this article, a new kind of a high-performance carbon block has been prepared via ceramic-bonded carbon (CBC) technology in a coke bed at 1673 K (1400 °C) using artificial graphite aggregate, alumina, metallic aluminum, and silicon powders as starting materials. The results showed that artificial graphite aggregates were strongly bonded by the three-dimensional network of ceramic phases in carbon blocks. In this case, the good resistance of the CBC blocks against erosion/corrosion by the hot metal is provided by the ceramic matrix and the high thermal conductivity by the graphite aggregates. The microstructure of this carbon block resembles that of CBC composites with a mean pore size of less than 0.1 μm, and up to 90 pct of the porosity shows a pore size <1 μm. Its thermal conductivity is higher than 30 W · m-1 · K-1 [293 K (20 °C)]. Meanwhile, its hot metal corrosion resistance is better than that of traditional carbon blocks.

Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players.

PubMed

Fraga, Cesar G; Actis-Goretta, Lucas; Ottaviani, Javier I; Carrasquedo, Fernando; Lotito, Silvina B; Lazarus, Sheryl; Schmitz, Harold H; Keen, Carl L

2005-03-01

The consumption of a diet rich in certain flavonoids, including the flavanol sub-class, has been associated with a reduced risk for vascular disease. We evaluated the effects of the regular consumption (14 d) of a flavanol-containing milk chocolate (FCMC) or cocoa butter chocolate (CBC) on variables related to vascular disease risk, oxidative stress and physical activity. Twenty-eight free-living, young (18-20 years old) male soccer players consumed daily 105 g of FCMC (168 mg of flavanols) or CBC (< 5 mg of flavanols), as part of their normal diet. The consumption of FCMC was significantly associated with a decrease in diastolic blood pressure (- 5 mm Hg), mean blood pressure (- 5 mm Hg), plasma cholesterol (-11%), LDL-cholesterol (-15%), malondialdehyde (- 12%), urate (- 11%) and lactate dehydrogenase (LDH) activity (- 11%), and an increase in vitamin E/cholesterol (+ 12%). No relevant changes in these variables were associated with CBC consumption. No changes in the plasma levels of (-)-epicatechin were observed following analysis of fasting blood samples. In conclusion, FCMC consumption was associated with changes in several variables often associated with cardiovascular health and oxidant stress. The presence of significant quantities of flavanols in FCMC is likely to have been one of the contributing factors to these results.

How to differentiate congenital from noncongenital chronic neutropenia at the first medical examination? Proposal of score: A pilot study from the French Severe Chronic Neutropenia registry.

PubMed

Bejjani, Naim; Beaupain, Blandine; Bertrand, Yves; Bellanne-Chantelot, Christine; Donadieu, Jean

2017-12-01

We developed a diagnostic score to differentiate congenital from noncongenital neutropenia at the time of diagnosis using reliable data collected at the first visit of a patients with neutropenia. In a pilot retrospective study, we included 120 patients diagnosed with chronic neutropenia; 61 had congenital and 59 had noncongenital neutropenia. We reviewed patient medical charts and collected the initial complete blood count (CBC) and other reliable data. We used logistic regression to determine the probability that the neutropenia was congenital. On the initial CBC, the degree of neutropenia had no predictive value; only monocytosis >1.5 × 10 9 /l, hemoglobin <90 g/l, or mild thrombocytopenia <150 × 10 9 /l suggested congenital neutropenia. The most predictive factors for congenital neutropenia were a medical history (consanguinity and patient history of neutropenia), severe infections, and oral stomatitis or gingivitis at the time of diagnosis. The age at diagnosis had limited predictive value. A diagnosis of congenital neutropenia may be reliably suspected based only on information from the CBC, some basic information from patient and parent interviews, and a clinical examination. A pilot score with six factors that could be readily, reliably collected, should facilitate the diagnosis of congenital neutropenia. © 2017 Wiley Periodicals, Inc.

Effects of Variety and Postharvest Handling Practices on Microbial Population at Different Stages of the Value Chain of Fresh Tomato (Solanum lycopersicum) in Western Terai of Nepal.

PubMed

Khadka, Ram B; Marasini, Madan; Rawal, Ranjana; Gautam, Durga M; Acedo, Antonio L

2017-01-01

Background . Fresh vegetables such as tomato should have low microbial population for safe consumption and long storage life. The aerobic bacterial count (ABC) and coliform bacterial count (CBC), yeast, and mold population are the most widely used microbial indicators in fresh vegetables which should be lower than 4 log CFU g -1 for safe consumption. The stages of the supply chain, postharvest handling methods, and crop varieties had significant effects on microbial population. ABC, CBC, yeast, and mold population were significantly highest ( P < 0.05) at retail market (5.59, 4.38, 2.60, and 3.14 log CFU g -1 , resp.), followed by wholesale market (4.72, 4.71, 2.43, and 2.44 log CFU g -1 , resp.), and were least at farm gate (3.89, 3.63, 2.38, and 2.03 log CFU g -1 , resp.). Improved postharvest practices (washing in clean water and grading and packaging in clean plastic crate) helped to reduce ABC, CBC, and mold population by 2.51, 32.70, and 29.86 percentage as compared to the conventional method (no washing and no grading and packaging in mud plastered bamboo baskets). Among varieties, Pusa ruby had the lowest microbial load of 2.58, 4.53, 0.96, and 1.77 log CFU g -1 for ABC, CBC, yeast, and mold count, respectively. Significantly negative correlation ( P < 0.05) was observed between fruit pH & ABC and pH & mold count. Although the microbial quality of fresh tomato is safe in the local market of western Terai of Nepal both in conventional and in improved practices however still it is essential to follow improved postharvest handling practices in production and marketing of newly introduced tomato cultivars (high-pH cultivars) for ensuring the safe availability of fresh tomato in the market.

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

PubMed

De Petrocellis, Luciano; Vellani, Vittorio; Schiano-Moriello, Aniello; Marini, Pietro; Magherini, Pier Cosimo; Orlando, Pierangelo; Di Marzo, Vincenzo

2008-06-01

The plant cannabinoids (phytocannabinoids), cannabidiol (CBD), and Delta(9)-tetrahydrocannabinol (THC) were previously shown to activate transient receptor potential channels of both vanilloid type 1 (TRPV1) and ankyrin type 1 (TRPA1), respectively. Furthermore, the endocannabinoid anandamide is known to activate TRPV1 and was recently found to antagonize the menthol- and icilin-sensitive transient receptor potential channels of melastatin type 8 (TRPM8). In this study, we investigated the effects of six phytocannabinoids [i.e., CBD, THC, CBD acid, THC acid, cannabichromene (CBC), and cannabigerol (CBG)] on TRPA1- and TRPM8-mediated increase in intracellular Ca2+ in either HEK-293 cells overexpressing the two channels or rat dorsal root ganglia (DRG) sensory neurons. All of the compounds tested induced TRPA1-mediated Ca2+ elevation in HEK-293 cells with efficacy comparable with that of mustard oil isothiocyanates (MO), the most potent being CBC (EC(50) = 60 nM) and the least potent being CBG and CBD acid (EC(50) = 3.4-12.0 microM). CBC also activated MO-sensitive DRG neurons, although with lower potency (EC(50) = 34.3 microM). Furthermore, although none of the compounds tested activated TRPM8-mediated Ca2+ elevation in HEK-293 cells, they all, with the exception of CBC, antagonized this response when it was induced by either menthol or icilin. CBD, CBG, THC, and THC acid were equipotent (IC(50) = 70-160 nM), whereas CBD acid was the least potent compound (IC(50) = 0.9-1.6 microM). CBG inhibited Ca2+ elevation also in icilin-sensitive DRG neurons with potency (IC(50) = 4.5 microM) similar to that of anandamide (IC(50) = 10 microM). Our findings suggest that phytocannabinoids and cannabis extracts exert some of their pharmacological actions also by interacting with TRPA1 and TRPM8 channels, with potential implications for the treatment of pain and cancer.

Effects of Variety and Postharvest Handling Practices on Microbial Population at Different Stages of the Value Chain of Fresh Tomato (Solanum lycopersicum) in Western Terai of Nepal

PubMed Central

Marasini, Madan; Rawal, Ranjana; Gautam, Durga M.; Acedo, Antonio L.

2017-01-01

Background. Fresh vegetables such as tomato should have low microbial population for safe consumption and long storage life. The aerobic bacterial count (ABC) and coliform bacterial count (CBC), yeast, and mold population are the most widely used microbial indicators in fresh vegetables which should be lower than 4 log CFU g−1 for safe consumption. The stages of the supply chain, postharvest handling methods, and crop varieties had significant effects on microbial population. ABC, CBC, yeast, and mold population were significantly highest (P < 0.05) at retail market (5.59, 4.38, 2.60, and 3.14 log CFU g−1, resp.), followed by wholesale market (4.72, 4.71, 2.43, and 2.44 log CFU g−1, resp.), and were least at farm gate (3.89, 3.63, 2.38, and 2.03 log CFU g−1, resp.). Improved postharvest practices (washing in clean water and grading and packaging in clean plastic crate) helped to reduce ABC, CBC, and mold population by 2.51, 32.70, and 29.86 percentage as compared to the conventional method (no washing and no grading and packaging in mud plastered bamboo baskets). Among varieties, Pusa ruby had the lowest microbial load of 2.58, 4.53, 0.96, and 1.77 log CFU g−1 for ABC, CBC, yeast, and mold count, respectively. Significantly negative correlation (P < 0.05) was observed between fruit pH & ABC and pH & mold count. Although the microbial quality of fresh tomato is safe in the local market of western Terai of Nepal both in conventional and in improved practices however still it is essential to follow improved postharvest handling practices in production and marketing of newly introduced tomato cultivars (high-pH cultivars) for ensuring the safe availability of fresh tomato in the market. PMID:29124068

CHEMICALLY BONDED CEMENTS FROM BOILER ASH AND SLUDGE WASTES. PHASE II REPORT, SEPT.1998-JULY 1999.

DOE Office of Scientific and Technical Information (OSTI.GOV)

SUGAMA,T.YAGER,K.A.BLANKENHORN,D.

1999-08-01

Based upon the previous Phase I research program aimed at looking for ways of recycling the KeySpan-generated wastes, such as waste water treatment sludge (WWTS) and bottom ash (BA), into the potentially useful cementitious materials called chemically bonded cement (CBC) materials, the emphasis of this Phase II program done at Brookhaven National Laboratory, in a period of September 1998 through July 1999, was directed towards the two major subjects: One was to assess the technical feasibility of WWTS-based CBC material for use as Pb-exchange adsorbent (PEA) which remediates Pb-contaminated soils in the field; and the other was related to themore » establishment of the optimum-packaging storage system of dry BA-based CBC components that make it a promising matrix material for the steam-cured concrete products containing sand and coarse aggregate. To achieve the goal of the first subject, a small-scale field demonstration test was carried out. Using the PEA material consisting of 30 wt% WWTS, 13 wt% Type I cement and 57 wt% water, the PES slurry was prepared using a rotary shear concrete mixer, and then poured on the Pb-contaminated soil. The PEA-to-soil ratio by weight was a factor of 2.0. The placed PEA slurry was blended with soil using hand mixing tools such as claws and shovels. The wettability of soils with the PEA was very good, thereby facilitating the soil-PEA mix procedures. A very promising result was obtained from this field test; in fact, the mount of Pb leached out from the 25-day-aged PEA-treated soil specimen was only 0.74 mg/l, meeting the requirement for EPA safe regulation of < 5 mg/l. In contrast, a large amount (26.4 mg/l) of Pb was detected from the untreated soil of the same age. Thus, this finding demonstrated that the WWTS-based CBC has a potential for use as PEA material. Regarding the second subject, the dry-packed storage system consisting of 68.7 wt% BA, 13.0 wt% calcium aluminate cement (CAC), 13.0 wt% Type I portland cement and 5.3 wt% sodium polyphosphate (NaP), was designed in response to the identification of the most effective CBC formulation in strengthening the steam-cured concrete specimens. Using this storage system with the material cost of 6.32 cents/lb, the 80 C-20 hour-steam-cured concrete specimens displayed the compressive strength of 3980 psi, tensile splitting of 416 psi, flexural strength of 808 psi, and modulus of elasticity of 3.16 x 10{sup 6} psi. Furthermore, the specimens had a good resistance to acid erosion and a lower permeability of water, compared with those of the conventional Type I cement concrete specimens. Consequently, the cost-effective BA-based CBC gave the promise of being a potentially useful material for fabricating high-performance precast concrete products, such as building blocks, pipes, and slabs.« less

Congressional Black Caucus meets with NASA

NASA Image and Video Library

2010-01-13

NASA Administrator Charles Bolden, space shuttle crew STS-129 and members of the Congressional Black Caucus pose for a group photo at the Capitol Building, Wednesday, Jan. 13, 2010, in Washington. Back row from left to right: U.S. Rep Donna Edwards (D-MD), U.S. Rep Diane Watson (D-CA), NASA Administrator Charles Bolden, astronauts Leland Melvin, Mike Foreman, Robert Satcher, Barry Wilmore, Randy Breznik, and U.S. Rep Mel Watt (D-NC). Front row from left to right: U.S. Rep Robert Scott (D-VA), U.S. Rep. Corrine Brown (D-Fla), U.S. Rep. Barbara Lee (D-CA), U.S. Rep. Donna Christensen (D-VI) and U.S. Rep. Donald Payne (D-NJ). The crew of STS-129 presented the CBC with a montage commemorating their mission. Photo Credit: (NASA/Paul E. Alers)

A Microfluidic Cytometer for Complete Blood Count With a 3.2-Megapixel, 1.1- μm-Pitch Super-Resolution Image Sensor in 65-nm BSI CMOS.

PubMed

Liu, Xu; Huang, Xiwei; Jiang, Yu; Xu, Hang; Guo, Jing; Hou, Han Wei; Yan, Mei; Yu, Hao

2017-08-01

Based on a 3.2-Megapixel 1.1- μm-pitch super-resolution (SR) CMOS image sensor in a 65-nm backside-illumination process, a lens-free microfluidic cytometer for complete blood count (CBC) is demonstrated in this paper. Backside-illumination improves resolution and contrast at the device level with elimination of surface treatment when integrated with microfluidic channels. A single-frame machine-learning-based SR processing is further realized at system level for resolution correction with minimum hardware resources. The demonstrated microfluidic cytometer can detect the platelet cells (< 2 μm) required in CBC, hence is promising for point-of-care diagnostics.

A joint watermarking/encryption algorithm for verifying medical image integrity and authenticity in both encrypted and spatial domains.

PubMed

Bouslimi, D; Coatrieux, G; Roux, Ch

2011-01-01

In this paper, we propose a new joint watermarking/encryption algorithm for the purpose of verifying the reliability of medical images in both encrypted and spatial domains. It combines a substitutive watermarking algorithm, the quantization index modulation (QIM), with a block cipher algorithm, the Advanced Encryption Standard (AES), in CBC mode of operation. The proposed solution gives access to the outcomes of the image integrity and of its origins even though the image is stored encrypted. Experimental results achieved on 8 bits encoded Ultrasound images illustrate the overall performances of the proposed scheme. By making use of the AES block cipher in CBC mode, the proposed solution is compliant with or transparent to the DICOM standard.

Enhancing the scientific value of the Christmas Bird Count

USGS Publications Warehouse

Dunn, Erica H.; Francis, C.M.; Blancher, P.J.; Drennan, S.R.; Howe, M.A.; Lepage, D.; Robbins, Chandler S.; Rosenberg, K.V.; Sauer, J.R.; Smith, Kimberly G.

2005-01-01

The Christmas Bird Count (CBC), conducted by the National Audubon Society (NAS) since 1900, constitutes the longest-running and geographically most widespread survey of bird life in the Western Hemisphere. Starting with 25 count locations in its first year, the program has grown continuously ever since, with 20–30 locations currently being added annually. Each CBC consists of a tally of all birds detected within a circle 24.1 km (15 miles) in diameter, on a single day within a few weeks around Christmas (current allowable dates are 14 December through 5 January). More than 50,000 observers now take part each year, in close to 2,000 count circles spread across the U.S. and its territories, southern Canada, and, increasingly, Latin America.

Cyanotic heart disease

MedlinePlus

... by checking it through the skin with a pulse oximeter Complete blood count (CBC) ECG (electrocardiogram) Looking at ... from the groin ( cardiac catheterization ) Transcutaneous oxygen monitor (pulse oximeter) Echo-Doppler

Sleeping sickness

MedlinePlus

... to confirm the diagnosis. Tests include the following: Blood smear to check for parasites Cerebrospinal fluid tests (fluid from your spinal cord) Complete blood count (CBC) Lymph node aspiration Treatment Medicines used ...

A Community-Based Culture Collection for Targeting Novel Plant Growth-Promoting Bacteria from the Sugarcane Microbiome

PubMed Central

Armanhi, Jaderson Silveira Leite; de Souza, Rafael Soares Correa; Damasceno, Natália de Brito; de Araújo, Laura M.; Imperial, Juan; Arruda, Paulo

2018-01-01

The soil-plant ecosystem harbors an immense microbial diversity that challenges investigative approaches to study traits underlying plant-microbe association. Studies solely based on culture-dependent techniques have overlooked most microbial diversity. Here we describe the concomitant use of culture-dependent and -independent techniques to target plant-beneficial microbial groups from the sugarcane microbiome. The community-based culture collection (CBC) approach was used to access microbes from roots and stalks. The CBC recovered 399 unique bacteria representing 15.9% of the rhizosphere core microbiome and 61.6–65.3% of the endophytic core microbiomes of stalks. By cross-referencing the CBC (culture-dependent) with the sugarcane microbiome profile (culture-independent), we designed a synthetic community comprised of naturally occurring highly abundant bacterial groups from roots and stalks, most of which has been poorly explored so far. We then used maize as a model to probe the abundance-based synthetic inoculant. We show that when inoculated in maize plants, members of the synthetic community efficiently colonize plant organs, displace the natural microbiota and dominate at 53.9% of the rhizosphere microbial abundance. As a result, inoculated plants increased biomass by 3.4-fold as compared to uninoculated plants. The results demonstrate that abundance-based synthetic inoculants can be successfully applied to recover beneficial plant microbes from plant microbiota. PMID:29354144

Acute effects of electronic and tobacco cigarette smoking on complete blood count.

PubMed

Flouris, Andreas D; Poulianiti, Konstantina P; Chorti, Maria S; Jamurtas, Athanasios Z; Kouretas, Dimitrios; Owolabi, Emmanuel O; Tzatzarakis, Manolis N; Tsatsakis, Aristidis M; Koutedakis, Yiannis

2012-10-01

The World Health Organisation called for research assessing the safety of electronic cigarette (e-cigarette). We evaluated the acute effect of active and passive e-cigarette and tobacco cigarette smoking on complete blood count (CBC) markers in 15 smokers and 15 never-smokers, respectively. Smokers underwent a control session, an active tobacco cigarette smoking session, and an active e-cigarette smoking session. Never-smokers underwent a control session, a passive tobacco cigarette smoking session, and a passive e-cigarette smoking session. The results demonstrated that CBC indices remained unchanged during the control session and the active and passive e-cigarette smoking sessions (P>0.05). Active and passive tobacco cigarette smoking increased white blood cell, lymphocyte, and granulocyte counts for at least one hour in smokers and never smokers (P<0.05). It is concluded that acute active and passive smoking using the e-cigarettes tested in the current study does not influence CBC indices in smokers and never smokers, respectively. In contrast, acute active and passive tobacco cigarette smoking increase the secondary proteins of acute inflammatory load for at least one hour. More research is needed to evaluate chemical safety issues and other areas of consumer product safety of e-cigarettes, because the nicotine content in the liquids used may vary considerably. Copyright © 2012 Elsevier Ltd. All rights reserved.

Pediatric dentistry clinical education venues evaluation by pre and post-doctoral students.

PubMed

Bimstein, E; Mayes, A; Mittal, Hc

2014-01-01

To evaluate dental students' perspectives about pre- and post-doctoral pediatric dentistry education venues. Surveys with visual analog scales (from 0 to 100) measuring the educational contribution of pediatric dentistry venues were conducted. The pre-doctoral venues included a 3rd year university twilight clinic (UTC), a 3rd year urban community based clinic (CBC) and 4th year mobile clinics (MCs). The post-doctoral venues included treatment of children under general anesthesia, oral sedations, a regular clinic (no sedations), seminars, journal club, case conferences and studding for the American Board of Pediatric Dentistry. Analyses of variance between the scores indicated that the 3rd year CBC score (68.2 ± 4.5) was statistically significant higher (p= .007) than the one for the 3rd year UTC score (44.9 ± 6.1). The 4th year students' MCs score (61.4 ± 4.0) was statistically significant higher than their retrospective scores for the 3rd year CBC (56.4 ± 4.4) or UTC (42.2 ± 4.9) scores (p= .03 and .004 respectively). Among the didactic or clinical post-doctoral venues, the regular clinic and the seminars received the highest scores (84.3 ± 1.7 and 71.6 ± 2.8 respectively). pre-doctoral community-based clinical education and post-doctoral regular university based clinic are considered by students to provide the main contribution to pediatric dental education.

Diagnosis and Management of Polycythemia Vera in a Ferret (Mustela putorius furo).

PubMed

Le, Kim; Beaufrère, Hugues; Bassel, Laura L; Wills, Sarah; Laniesse, Delphine; Blois, Shauna L; Smith, Dale A

2016-12-01

A 5-y-old female ferret (Mustela putorius furo) was evaluated for diarrhea, anorexia, and lethargy for 1 wk. Only mild dehydration was detected on physical examination. CBC analysis revealed marked erythrocytosis with an unremarkable plasma biochemistry panel; follow-up CBC analyses revealed a consistent primary erythrocytosis. Whole-body radiographs and abdominal ultrasonography were unremarkable except for a small nephrolith in the right kidney and a small cyst in the left kidney. The plasma erythropoietin level was 17.0 mIU/mL and considered normal. In light of the diagnostic work-up and consistent erythrocytosis, a diagnosis of polycythemia vera (primary erythrocytosis) was made. The initial presentation of diarrhea resolved after treatment with oral metronidazole (20 mg/kg PO BID for 7 d). Treatment for the polycythemia consisted of a phlebotomy initially followed by chemotherapy with hydroxyurea (10 mg/kg PO BID). During the subsequent 12 mo, the hydroxyurea dose adjusted according to follow-up CBC results, and finding an optimal dosage regimen proved to be challenging. One year after the initial diagnosis, the ferret presented to an emergency clinic for acute and severe hemorrhagic diarrhea and died shortly thereafter. The postmortem diagnosis was acute venous infarction of the small and large intestine. To our knowledge, this report is the first to describe the diagnosis and long-term management of polycythemia vera in a ferret and the use of hydroxyurea for this purpose.

Systems Analysis of the Response of Photosynthesis, Metabolism, and Growth to an Increase in Irradiance in the Photosynthetic Model Organism Chlamydomonas reinhardtii[C][W][OPEN

PubMed Central

Mettler, Tabea; Mühlhaus, Timo; Hemme, Dorothea; Schöttler, Mark-Aurel; Rupprecht, Jens; Idoine, Adam; Veyel, Daniel; Pal, Sunil Kumar; Yaneva-Roder, Liliya; Winck, Flavia Vischi; Sommer, Frederik; Vosloh, Daniel; Seiwert, Bettina; Erban, Alexander; Burgos, Asdrubal; Arvidsson, Samuel; Schönfelder, Stephanie; Arnold, Anne; Günther, Manuela; Krause, Ursula; Lohse, Marc; Kopka, Joachim; Nikoloski, Zoran; Mueller-Roeber, Bernd; Willmitzer, Lothar; Bock, Ralph; Schroda, Michael; Stitt, Mark

2014-01-01

We investigated the systems response of metabolism and growth after an increase in irradiance in the nonsaturating range in the algal model Chlamydomonas reinhardtii. In a three-step process, photosynthesis and the levels of metabolites increased immediately, growth increased after 10 to 15 min, and transcript and protein abundance responded by 40 and 120 to 240 min, respectively. In the first phase, starch and metabolites provided a transient buffer for carbon until growth increased. This uncouples photosynthesis from growth in a fluctuating light environment. In the first and second phases, rising metabolite levels and increased polysome loading drove an increase in fluxes. Most Calvin-Benson cycle (CBC) enzymes were substrate-limited in vivo, and strikingly, many were present at higher concentrations than their substrates, explaining how rising metabolite levels stimulate CBC flux. Rubisco, fructose-1,6-biosphosphatase, and seduheptulose-1,7-bisphosphatase were close to substrate saturation in vivo, and flux was increased by posttranslational activation. In the third phase, changes in abundance of particular proteins, including increases in plastidial ATP synthase and some CBC enzymes, relieved potential bottlenecks and readjusted protein allocation between different processes. Despite reasonable overall agreement between changes in transcript and protein abundance (R2 = 0.24), many proteins, including those in photosynthesis, changed independently of transcript abundance. PMID:24894045

ATM, radiation, and the risk of second primary breast cancer.

PubMed

Bernstein, Jonine L; Concannon, Patrick

2017-10-01

It was first suggested more than 40 years ago that heterozygous carriers for the human autosomal recessive disorder Ataxia-Telangiectasia (A-T) might also be at increased risk for cancer. Subsequent studies have identified the responsible gene, Ataxia-Telangiectasia Mutated (ATM), characterized genetic variation at this locus in A-T and a variety of different cancers, and described the functions of the ATM protein with regard to cellular DNA damage responses. However, an overall model of how ATM contributes to cancer risk, and in particular, the role of DNA damage in this process, remains lacking. This review considers these questions in the context of contralateral breast cancer (CBC). Heterozygous carriers of loss of function mutations in ATM that are A-T causing, are at increased risk of breast cancer. However, examination of a range of genetic variants, both rare and common, across multiple cancers, suggests that ATM may have additional effects on cancer risk that are allele-dependent. In the case of CBC, selected common alleles at ATM are associated with a reduced incidence of CBC, while other rare and predicted deleterious variants may act jointly with radiation exposure to increase risk. Further studies that characterize germline and somatic ATM mutations in breast cancer and relate the detected genetic changes to functional outcomes, particularly with regard to radiation responses, are needed to gain a complete picture of the complex relationship between ATM, radiation and breast cancer.

Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or β-Thalassemia Trait?

PubMed Central

Susanti, Ari Indra; Winarno, Gatot; Sugianli, Adhi Kristianto; Susanto, Herman; Panigoro, Ramdan

2017-01-01

Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficiency (IDA) or β-thalassemia trait (β-TT). Pregnant women (n = 105) had finger prick test for Hb level during a regular antenatal care examination from October to November 2016. Hb level by finger prick test was compared with venous blood, measured by complete blood count (CBC). Indices including MCV and MCH and indices of Shine & Lal, Mentzer, Srivastava, Engels & Frase, Ehsani, and Sirdah were analyzed to differentiate anemia due to IDA and anemia due to suspect β-TT. HbA2 was measured to confirm β-TT. Anemic pregnant women were found in 86.7% by finger prick test compared to 21.9% (n = 23) by CBC. The prevalence of β-TT in our study was 5.7%. Hb measurement among pregnant women in low resource area is highly important; however, finger prick test in this study showed a high frequency of anemia which may lead to iron oversupplementation. A standard CBC is encouraged; MCV and MCH would help midwives to identify β-TT. PMID:28634546

CBC

MedlinePlus

... count results, such as chronic kidney disease Normal Results Blood counts may vary with altitude. In general, ... meaning of your specific test results. What Abnormal Results Mean High RBC, hemoglobin, or hematocrit may be ...

High-energy proton irradiation of C57Bl6 mice under hindlimb unloading

NASA Astrophysics Data System (ADS)

Mendonca, Marc; Todd, Paul; Orschell, Christie; Chin-Sinex, Helen; Farr, Jonathan; Klein, Susan; Sokol, Paul

2012-07-01

Solar proton events (SPEs) pose substantial risk for crewmembers on deep space missions. It has been shown that low gravity and ionizing radiation both produce transient anemia and immunodeficiencies. We utilized the C57Bl/6 based hindlimb suspension model to investigate the consequences of hindlimb-unloading induced immune suppression on the sensitivity to whole body irradiation with modulated 208 MeV protons. Eight-week old C57Bl/6 female mice were conditioned by hindlimb-unloading. Serial CBC and hematocrit assays by HEMAVET were accumulated for the hindlimb-unloaded mice and parallel control animals subjected to identical conditions without unloading. One week of hindlimb-unloading resulted in a persistent, statistically significant 10% reduction in RBC count and a persistent, statistically significant 35% drop in lymphocyte count. This inhibition is consistent with published observations of low Earth orbit flown mice and with crewmember blood analyses. In our experiments the cell count suppression was sustained for the entire six-week period of observation and persisted for at least 7 days beyond the period of active hindlimb-unloading. C57Bl/6 mice were also irradiated with 208 MeV Spread Out Bragg Peak (SOBP) protons at the Midwest Proton Radiotherapy Institute at the Indiana University Cyclotron Facility. We found that at 8.5 Gy hindlimb-unloaded mice were significantly more radiation sensitive with 35 lethalities out of 51 mice versus 15 out of 45 control (non-suspended) mice within 30 days of receiving 8.5 Gy of SOBP protons (p =0.001). Both control and hindlimb-unloaded stocktickerCBC analyses of 8.5 Gy proton irradiated and control mice by HEMAVET demonstrated severe reductions in WBC counts (Lymphocytes and PMNs) by day 2 post-irradiation, followed a week to ten days later by reductions in platelets, and then reductions in RBCs about 2 weeks post-irradiation. Recovery of all blood components commenced by three weeks post-irradiation. CBC analyses of 8.5 Gy proton irradiated hindlimb-unloaded mice indicated that the recovery of the WBC counts appeared delayed compared to 8.5 Gy irradiated controls. However, stocktickerRBC recovery appeared similar in both sets of irradiated mice. Our data indicate that hindlimb-unloaded mice are more radiation sensitive compared to irradiated controls. We thank Brian Allen and Rick Jessup for valuable assistance with dosimetry and physical arrangements at the IU Cyclotron Facility and Midwest Proton Radiotherapy Institute and Alan Constance for design of hindlimb-unloading cages. Research supported in part by NASA Grant NNJ06HE95A.

Kids' Medical Dictionary

MedlinePlus

... Chronic Word! Cleft Lip Word! Cleft Palate Word! Cochlea Word! Complete Blood Count (CBC) Word! Cone Word! ... Word! Palpitations Word! Pancreas Word! Papillae Word! Peak Flow Meter Word! Pediatric Endocrinologist Word! Pediatrician Word! Peritonitis ...

TIBC, UIBC and Transferrin

MedlinePlus

... 28 weeks to delivery) Primary Aldosteronism (Conn Syndrome) Prostate Cancer Protein in Urine (Proteinuria) Reactive Arthritis Rheumatoid Arthritis ... Blood Count (CBC) Hemoglobin Hematocrit Reticulocytes Soluble Transferrin Receptor Conditions Anemia Hemochromatosis Elsewhere On The Web American ...

Burkitt lymphoma

MedlinePlus

The health care provider will perform a physical exam. Tests include: Bone marrow biopsy Chest x-ray CT scan of the chest, abdomen, and pelvis Complete blood count (CBC) Examination of the spinal fluid Lymph node biopsy PET scan

Ankylosing spondylitis

MedlinePlus

... Most people with AS are positive for the HLA-B27 gene. The disease often begins between ages 20 ... may include: CBC ESR (a measure of inflammation) HLA-B27 antigen (which detects the gene linked to ankylosing ...

Camp Minden Draft QASP and Work Plan for Public Feedback

EPA Pesticide Factsheets

ESI has developed these operational plans, technical approaches, and related required resources based upon extensive review and planning for material removal, transportation, staging, and Contained Burn Chamber (CBC) destruction of materials.

Medullary cystic kidney disease

MedlinePlus

... Tests that may be done include: 24-hour urine volume and electrolytes Blood urea nitrogen (BUN) Complete blood count (CBC) Creatinine blood test Creatinine clearance -- blood and urine Uric acid blood test Urine specific gravity (will ...

Value redefined for inflammatory bowel disease patients: a choice-based conjoint analysis of patients' preferences.

PubMed

van Deen, Welmoed K; Nguyen, Dominic; Duran, Natalie E; Kane, Ellen; van Oijen, Martijn G H; Hommes, Daniel W

2017-02-01

Value-based healthcare is an upcoming field. The core idea is to evaluate care based on achieved outcomes divided by the costs. Unfortunately, the optimal way to evaluate outcomes is ill-defined. In this study, we aim to develop a single, preference based, outcome metric, which can be used to quantify overall health value in inflammatory bowel disease (IBD). IBD patients filled out a choice-based conjoint (CBC) questionnaire in which patients chose preferable outcome scenarios with different levels of disease control (DC), quality of life (QoL), and productivity (Pr). A CBC analysis was performed to estimate the relative value of DC, QoL, and Pr. A patient-centered composite score was developed which was weighted based on the stated preferences. We included 210 IBD patients. Large differences in stated preferences were observed. Increases from low to intermediate outcome levels were valued more than increases from intermediate to high outcome levels. Overall, QoL was more important to patients than DC or Pr. Individual outcome scores were calculated based on the stated preferences. This score was significantly different from a score not weighted based on patient preferences in patients with active disease. We showed the feasibility of creating a single outcome metric in IBD which incorporates patients' values using a CBC. Because this metric changes significantly when weighted according to patients' values, we propose that success in healthcare should be measured accordingly.

Potential substitution of cord blood for infant blood in the neonatal sepsis evaluation.

PubMed

Hansen, Anne; Forbes, Peter; Buck, Rosanne

2005-01-01

Evaluation of sepsis accounts for one third of all nursery triage admissions. If umbilical cord blood could be accurately substituted for infant blood, it would spare infants the discomfort of an invasive procedure and save both time and resources. While awaiting 48-hour blood culture results, we decide on clinical management based on whether the white blood cell (WBC) immature to total (I:T) granulocyte ratio is >or=0.2. Our goal was to assess the correlation of complete blood count (CBC), I:T ratio and blood culture results between umbilical cord and infant blood. We conducted a prospective cohort study comparing CBC/differential and blood culture results of paired samples of umbilical cord and infant blood from term newborns. We sent 113 paired samples of cord and infant venous blood for CBC/differential and blood culture. All 113 umbilical cord and infant blood cultures were negative, yielding a false-positive blood culture rate of zero. For 92% of babies, both the cord and infant blood I:T ratio were <0.2 or both were >or=0.2. Cord and infant WBC, hematocrit and platelet counts were moderately to highly correlated. We conclude that cord blood can be safely substituted for infant blood in routine sepsis evaluations of asymptomatic, term infants based on both the low false-positive cord blood culture rate and the significant association between high I:T ratios in cord and infant blood. Copyright (c) 2005 S. Karger AG, Basel.

Utility of arterial blood gas, CBC, biochemistry and cardiac hormones as evaluation parameters of cardiovascular disease in nonhuman primates.

PubMed

Nakayama, Shunya; Koie, Hiroshi; Kanayama, Kiichi; Katakai, Yuko; Ito-Fujishiro, Yasuyo; Sankai, Tadashi; Yasutomi, Yasuhiro; Ageyama, Naohide

2018-06-11

Cardiovascular disease (CVD) has a tremendous impact on the quality of life of humans. While experimental animals are valuable to medical research as models of human diseases, cardiac systems differ widely across various animal species. Thus, we examined a CVD model in cynomolgus monkeys. Laboratory primates are precious resources, making it imperative that symptoms of diseases and disorders are detected as early as possible. Thus, in this study we comprehensively examined important indicators of CVD in cynomolgus monkeys, including arterial blood gas, complete blood count (CBC), biochemistry, and cardiac hormones. The control group included 20 healthy macaques showing non-abnormal findings in screening tests, whereas the CVD group included 20 macaques with valvular disease and cardiomyopathy. An increase of red blood cell distribution width was observed in the CBC, indicating chronic inflammation related to CVD. An increase of HCO 3 was attributed to the correction of acidosis. Furthermore, development of the CVD model was supported by significant increases in natriuretic peptides. It is suggested that these results indicated a correlation between human CVD and the model in monkeys. Moreover, blood tests including arterial blood gas are non-invasive and can be performed more easily than other technical tests. CVD affected animals easily change their condition by anesthesia and surgical invasion. Pay attention to arterial blood gas and proper respond to their condition are important for research. This data may facilitate human research and aid in the management and veterinary care of nonhuman primates.

Comparison of the effects of Mitomycin-C and sodium hyaluronate/carboxymethylcellulose [NH/CMC] (Seprafilm) on abdominal adhesions.

PubMed

Ozerhan, Ismail Hakkı; Urkan, Murat; Meral, Ulvi Mehmet; Unlu, Aytekin; Ersöz, Nail; Demirag, Funda; Yagci, Gokhan

2016-01-01

Intra-abdominal adhesions (IA) may occur after abdominal surgery and also may lead to complications such as infertility, intestinal obstruction and chronic pain. The aim of this study was to compare the effects of Mitomycin-C (MM-C) and sodium hyaluronate/carboxymethylcellulose [NH/CMC] on abdominal adhesions in a cecal abrasion model and to investigate the toxicity of MM-C on complete blood count (CBC) and bone marrow analyses. The study comprised forty rats in four groups (Control, Sham, Cecal abrasion + MM-C, and Cecal abrasion + NH/CMC). On postoperative day 21, all rats except for the control (CBC + femur resection) group, were sacrificed. Macroscopical and histopathological evaluations of abdominal adhesions were performed. In order to elucidate the side effects of MM-C; CBC analyses and femur resections were performed to examine bone marrow cellularity. CBC analyses and bone marrow cellularity assessment revealed no statistically significant differences between MM-C, NH/CMC and control groups. No significant differences in inflammation scores were observed between the groups. The MM-C group had significantly lower fibrosis scores compared to the NH/CMC and sham groups. Although the adhesion scores were lower in the MM-C group, the differences were not statistically significant. Despite its potential for systemic toxicity, MM-C may show some anti-fibrosis and anti-adhesive effects. MM-C is a promising agent for the prevention of IAs, and as such, further trials are warranted to study efficacy.

Using time series structural characteristics to analyze grain prices in food insecure countries

USGS Publications Warehouse

Davenport, Frank; Funk, Chris

2015-01-01

Two components of food security monitoring are accurate forecasts of local grain prices and the ability to identify unusual price behavior. We evaluated a method that can both facilitate forecasts of cross-country grain price data and identify dissimilarities in price behavior across multiple markets. This method, characteristic based clustering (CBC), identifies similarities in multiple time series based on structural characteristics in the data. Here, we conducted a simulation experiment to determine if CBC can be used to improve the accuracy of maize price forecasts. We then compared forecast accuracies among clustered and non-clustered price series over a rolling time horizon. We found that the accuracy of forecasts on clusters of time series were equal to or worse than forecasts based on individual time series. However, in the following experiment we found that CBC was still useful for price analysis. We used the clusters to explore the similarity of price behavior among Kenyan maize markets. We found that price behavior in the isolated markets of Mandera and Marsabit has become increasingly dissimilar from markets in other Kenyan cities, and that these dissimilarities could not be explained solely by geographic distance. The structural isolation of Mandera and Marsabit that we find in this paper is supported by field studies on food security and market integration in Kenya. Our results suggest that a market with a unique price series (as measured by structural characteristics that differ from neighboring markets) may lack market integration and food security.

Association Between Hematological Indices and Coronary Calcification in Symptomatic Patients without History of Coronary Artery Disease

PubMed Central

Chaikriangkrai, Kongkiat; Kassi, Mahwash; Alchalabi, Sama; Bala, Sayf Khaleel; Adigun, Rosalyn; Botero, Sharleen; Chang, Su Min

2014-01-01

Background: Atherosclerotic coronary artery disease (CAD) has long been shown to involve chronic low-grade subclinical inflammation. However, whether there is association between hematological indices assessed by complete blood count (CBC) and coronary atherosclerotic burden has not been well studied. Materials and Methods: Consecutive 868 patients without known CAD who presented with acute chest pain to emergency department and underwent coronary artery calcium (CAC) scoring evaluation by multi-detector cardiac computed tomography were included in our study. Clinical characteristics and CBC indices were compared among different CAC groups. Results: The cohort comprised 60% male with a mean age of 61 (SD = 14) years. Median Framingham risk of CAD was 4% (range 1-16%). Median CAC score was 0 (IQR 0-43). Higher CAC groups had significantly higher Framingham risk of CAD than lower CAC groups (P < 0.001). Among different CAC categories, there was no statistically significant difference in hemoglobin level (p 0.45), mean corpuscular volume (p 0.43), mean corpuscular hemoglobin (p 0.28), mean corpuscular hemoglobin volume (p 0.36), red cell distribution width (0.42), total white blood cell counts (p 0.291), neutrophil counts (p 0.352), lymphocyte counts (p 0.92), neutrophil to lymphocyte ratio (p 0.68), monocyte count (p 0.48), and platelet counts (p 0.25). Conclusion: Our study did not detect significant association between hematological indices assessed with CBC and coronary calcification in symptomatic patients without known CAD. PMID:25317386

How national context, project design, and local community characteristics influence success in community-based conservation projects.

PubMed

Brooks, Jeremy S; Waylen, Kerry A; Borgerhoff Mulder, Monique

2012-12-26

Community-based conservation (CBC) promotes the idea that conservation success requires engaging with, and providing benefits for, local communities. However, CBC projects are neither consistently successful nor free of controversy. Innovative recent studies evaluating the factors associated with success and failure typically examine only a single resource domain, have limited geographic scope, consider only one outcome, or ignore the nested nature of socioecological systems. To remedy these issues, we use a global comparative database of CBC projects identified by systematic review to evaluate success in four outcome domains (attitudes, behaviors, ecological, economic) and explore synergies and trade-offs among these outcomes. We test hypotheses about how features of the national context, project design, and local community characteristics affect these measures of success. Using bivariate analyses and multivariate proportional odds logistic regressions within a multilevel analysis and model-fitting framework, we show that project design, particularly capacity-building in local communities, is associated with success across all outcomes. In addition, some characteristics of the local community in which projects are conducted, such as tenure regimes and supportive cultural beliefs and institutions, are important for project success. Surprisingly, there is little evidence that national context systematically influences project outcomes. We also find evidence of synergies between pairs of outcomes, particularly between ecological and economic success. We suggest that well-designed and implemented projects can overcome many of the obstacles imposed by local and national conditions to succeed in multiple domains.

Diskitis

MedlinePlus

... The health care provider will perform a physical exam and ask about the symptoms. Tests that may be ordered include any of the following: Bone scan Complete blood count ( CBC ) ESR or C-reactive protein to measure inflammation MRI of the ...

Magnetic Resonance Imaging (MRI)

MedlinePlus

... MoreBMI Calculator Complete Blood Count (CBC)Blood Test: Lipid PanelRapid Strep TestPelvic UltrasoundAbdominal UltrasoundCT Head ScanPap Smear ( ... because it can provide images of internal body structures. It is more like a CT scan than ...

76 FR 27755 - Endangered and Threatened Wildlife and Plants; Withdrawal of the Proposed Rule To List the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

..., low precipitation, and wind scour, features they predicted would persist over time, especially on... Christmas Bird Count (CBC), suffer from a variety of problems, including the inherent difficulties...

Cholangiocarcinoma

MedlinePlus

... microscope Blood tests that may be done include: Liver function tests (especially alkaline phosphatase or bilirubin levels) Complete blood count (CBC) Treatment ... and may result in a cure. If the tumor is large, the entire liver may need to be removed and a liver ...

Pulmonary actinomycosis

MedlinePlus

The health care provider will perform a physical exam, and ask about your medical history and symptoms. Tests that may be done include: Bronchoscopy with culture Complete blood count (CBC) Chest x-ray Chest CT scan Lung biopsy Modified AFB smear of sputum ...

Complete Blood Count (For Parents)

MedlinePlus

... Test: Basic Metabolic Panel (BMP) Blood Test: Hemoglobin Basic Blood Chemistry Tests Word! Complete Blood Count (CBC) Medical Tests and Procedures (Video Landing Page) Getting a Blood Test (Video) Medical Tests: What to Expect ... View more About Us Contact Us ...

Ultrapure Water System for Hemodialysis Therapy

ClinicalTrials.gov

2011-07-21

The Change of Biomarkers CRP, CBC With the Use of Ultra Pure Water System for; Hemodialysis.; The Rate of Adverse Events Such as Hypotension During Hemodialysis Therapy With Ultra Pure Water; System as Compared to Conventional Water System.

Concept-Based Curricula: A National Study of Critical Concepts.

PubMed

Brussow, Jennifer A; Roberts, Karin; Scaruto, Matthew; Sommer, Sheryl; Mills, Christine

2018-02-22

As nursing education struggles to address a rapidly changing health care system, overcrowded curricula, and an increased focus on clinical reasoning skills, many programs have adopted or transitioned to concept-based curricula (CBCs), which are structured around key concepts and exemplars. Despite CBC's promised benefits, the process of developing a CBC framework may pose a challenge to programs. To address this barrier, a national study was conducted to develop a representative list of concepts and exemplars. This initiative expands on prior work by suggesting a leveled approach to positioning exemplars within a curricular sequence.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Food and nutrition in Canadian "prime time" television commercials.

PubMed

Ostbye, T; Pomerleau, J; White, M; Coolich, M; McWhinney, J

1993-01-01

Television is, arguably, the most influential mass medium and "prime time" viewing attracts the largest audiences. To assess the type, number and nutritional content of foods advertised on TV, commercial breaks during "prime time" (7:00 to 11:00 p.m.) on five Canadian channels (CBC-English, CBC-French, CTV, CFPL, Much Music) were recorded and analyzed. A similar analysis of Saturday morning children's TV commercials was also performed. Commercials for foods and food products constituted between 24-35% of all commercials, the largest advertising output for any group of products. The combination of food presented in commercials reflected average current consumption patterns. Of special concern was the emphasis on low nutrition beverages, especially beer, as well as snacks and candy on Much Music. While further government intervention to restrict advertising practices may be an impractical option, there is scope for increasing the alternative promotion of healthy dietary choices.

Autovalidation and automation of the postanalytical phase of routine hematology and coagulation analyses in a university hospital laboratory.

PubMed

Mlinaric, Ana; Milos, Marija; Coen Herak, Désirée; Fucek, Mirjana; Rimac, Vladimira; Zadro, Renata; Rogic, Dunja

2018-02-23

The need to satisfy high-throughput demands for laboratory tests continues to be a challenge. Therefore, we aimed to automate postanalytical phase in hematology and coagulation laboratory by autovalidation of complete blood count (CBC) and routine coagulation test results (prothrombin time [PT], international normalized ratio [PT-INR], activated partial thromboplastin time [APTT], fibrinogen, antithrombin activity [AT] and thrombin time [TT]). Work efficacy and turnaround time (TAT) before and after implementation of automated solutions will be compared. Ordering panels tailored to specific patient populations were implemented. Rerun and reflex testing rules were set in the respective analyzers' software (Coulter DxH Connectivity 1601, Beckman Coulter, FL, USA; AutoAssistant, Siemens Healthcare Diagnostics, Germany), and sample status information was transferred into the laboratory information system. To evaluate if the automation improved TAT and efficacy, data from manually verified results in September and October of 2015 were compared with the corresponding period in 2016 when autovalidation was implemented. Autovalidation rates of 63% for CBC and 65% for routine coagulation test results were achieved. At the TAT of 120 min, the percentage of reported results increased substantially for all analyzed tests, being above 90% for CBC, PT, PT-INR and fibrinogen and 89% for APTT. This output was achieved with three laboratory technicians less compared with the period when the postanalytical phase was not automated. Automation allowed optimized laboratory workflow for specific patient populations, thereby ensuring standardized results reporting. Autovalidation of test results proved to be an efficient tool for improvement of laboratory work efficacy and TAT.

[Monograph for 3-(4-methylbenzylidene)camphor (4-MBC)--HBM values for the sum of metabolites 3-(4-carboxybenzylidene)camphor (3-4CBC) and 3-(4-carboxybenzylidene)-6-hydroxycamphor (3-4 CBHC) in the urine of adults and children. Statement of the HBM Commission of the German Federal Environment Agency].

PubMed

2016-01-01

The substance 3-(4-methylbenzylidene)camphor (4-MBC, CAS-No. 36861-47-9 as well as 38102-62-4) is used as UV-filter in cosmetics, mainly in sunscreen lotions. National as well as European evaluations are available for the substance, especially from the Scientific Committee on Consumer Products (SCCP). The SCCP did not derive a TDI-value, but used for a MoS assessment a NOAEL of 25 mg/(kg bw · d) based on effects on the thyroid gland of rats in a subchronic study with oral administration. Newer studies, however, indicate lower NOAEL values, leading to tolerable daily intakes of 0,01 mg/kg bw. The HBM Commission established for the metabolite 3-(4-carboxybenzylidene)camphor (3-4CBC) HBM-I values of 0,09 mg/l urine for adults and 0,06 mg/l urine for children. HBM-I values for the metabolite 3-(4-carboxybenzylidene)-6-hydroxycamphor (3-4CBHC) were set at 0,38 mg/l urine for adults and 0,25 mg/l urine for children. The rounded HBM-I value for the sum of metabolites 3-4CBC und 3-4CBHC is accordingly 0,5 mg/l urine for adults and 0,3 mg/l urine for children.

Does community-based conservation shape favorable attitudes among locals? an empirical study from nepal.

PubMed

Mehta, J N; Heinen, J T

2001-08-01

Like many developing countries, Nepal has adopted a community-based conservation (CBC) approach in recent years to manage its protected areas mainly in response to poor park-people relations. Among other things, under this approach the government has created new "people-oriented" conservation areas, formed and devolved legal authority to grassroots-level institutions to manage local resources, fostered infrastructure development, promoted tourism, and provided income-generating trainings to local people. Of interest to policy-makers and resource managers in Nepal and worldwide is whether this approach to conservation leads to improved attitudes on the part of local people. It is also important to know if personal costs and benefits associated with various intervention programs, and socioeconomic and demographic characteristics influence these attitudes. We explore these questions by looking at the experiences in Annapurna and Makalu-Barun Conservation Areas, Nepal, which have largely adopted a CBC approach in policy formulation, planning, and management. The research was conducted during 1996 and 1997; the data collection methods included random household questionnaire surveys, informal interviews, and review of official records and published literature. The results indicated that the majority of local people held favorable attitudes toward these conservation areas. Logistic regression results revealed that participation in training, benefit from tourism, wildlife depredation issue, ethnicity, gender, and education level were the significant predictors of local attitudes in one or the other conservation area. We conclude that the CBC approach has potential to shape favorable local attitudes and that these attitudes will be mediated by some personal attributes.

Contralateral prophylactic mastectomy: current perspectives

PubMed Central

Yao, Katharine; Sisco, Mark; Bedrosian, Isabelle

2016-01-01

There has been an increasing trend in the use of contralateral prophylactic mastectomy (CPM) in the United States among women diagnosed with unilateral breast cancer, particularly young women. Approximately one-third of women <40 years old are undergoing CPM in the US. Most studies have shown that the CPM trend is mainly patient-driven, which reflects a changing environment for newly diagnosed breast cancer patients. The most common reason that women choose CPM is based on misperceptions about CPM’s effect on survival and overestimation of their contralateral breast cancer (CBC) risk. No prospective studies have shown survival benefit to CPM, and the CBC rate for most women is low at 10 years. Fear of recurrence is also a big driver of CPM decisions. Nonetheless, studies have shown that women are mostly satisfied with undergoing CPM, but complications and subsequent surgeries with reconstruction have been associated with dissatisfaction with CPM. Studies on surgeon’s perspectives on CPM are sparse but show that the most common reasons surgeons discuss CPM with patients is because of a suspicious family history or for a patient who is a confirmed BRCA mutation carrier. Studies on the cost–effectiveness of CPM have been conflicting and are highly dependent on patient’s quality of life after CPM. Most recent guidelines for CPM are contradictory. Future areas of research include the development of interventions to better inform patients about CPM, modification of the guidelines to form a more consistent statement, longer term studies on CBC risk and CPM’s effect on survival, and prospective studies that track the psychosocial effects of CPM on body image and sexuality. PMID:27382334

Evaluation of supervised machine-learning algorithms to distinguish between inflammatory bowel disease and alimentary lymphoma in cats.

PubMed

Awaysheh, Abdullah; Wilcke, Jeffrey; Elvinger, François; Rees, Loren; Fan, Weiguo; Zimmerman, Kurt L

2016-11-01

Inflammatory bowel disease (IBD) and alimentary lymphoma (ALA) are common gastrointestinal diseases in cats. The very similar clinical signs and histopathologic features of these diseases make the distinction between them diagnostically challenging. We tested the use of supervised machine-learning algorithms to differentiate between the 2 diseases using data generated from noninvasive diagnostic tests. Three prediction models were developed using 3 machine-learning algorithms: naive Bayes, decision trees, and artificial neural networks. The models were trained and tested on data from complete blood count (CBC) and serum chemistry (SC) results for the following 3 groups of client-owned cats: normal, inflammatory bowel disease (IBD), or alimentary lymphoma (ALA). Naive Bayes and artificial neural networks achieved higher classification accuracy (sensitivities of 70.8% and 69.2%, respectively) than the decision tree algorithm (63%, p < 0.0001). The areas under the receiver-operating characteristic curve for classifying cases into the 3 categories was 83% by naive Bayes, 79% by decision tree, and 82% by artificial neural networks. Prediction models using machine learning provided a method for distinguishing between ALA-IBD, ALA-normal, and IBD-normal. The naive Bayes and artificial neural networks classifiers used 10 and 4 of the CBC and SC variables, respectively, to outperform the C4.5 decision tree, which used 5 CBC and SC variables in classifying cats into the 3 classes. These models can provide another noninvasive diagnostic tool to assist clinicians with differentiating between IBD and ALA, and between diseased and nondiseased cats. © 2016 The Author(s).

Clinically healthy overweight and obese dogs differ from lean controls in select CBC and serum biochemistry values.

PubMed

Radakovich, Lauren B; Truelove, Matthew P; Pannone, Stephen C; Olver, Christine S; Santangelo, Kelly S

2017-06-01

Obesity is a global disease, affecting nearly half a billion people. Unfortunately, this trend is mirrored in our canine population. As obesity is a complex inflammatory disease, there is a need to determine whether routine medical screening tests may indicate, or be influenced by, its presence. The objective of the current study was to determine if significant differences exist between CBC and biochemical profile values from control vs overweight/obese, client-owned dogs considered clinically healthy. Dogs presented for routine health examinations, including minor dental or elective surgical procedures, were retrospectively identified from a hospital population. Animals were allocated to 2 categories based on body condition score (BCS), and data were analyzed by Mann-Whitney nonparametric analysis with statistical significance at a P ≤ .05. After exclusions, 116 dogs were assigned to the overweight/obese group (BCS ≥ 7) and 240 dogs to the control group (BCS = 4-6). Overweight/obese dogs had higher total leukocyte counts and higher plasma protein and globulin concentrations. Other differences were attributed to decreased serum water fraction (increased sodium, albumin, calcium, and anion gap) in the overweight/obese group. Interestingly, chloride concentration was decreased (in the face of increased sodium) in the obese group. There is CBC and biochemical evidence to support the concern that obesity influences laboratory values, even in dogs considered clinically healthy. Prospective studies aimed at characterizing these changes are needed to provide insight into the connection between obesity and its comorbidities. © 2017 American Society for Veterinary Clinical Pathology.

Social influence on temptation: perceived descriptive norms, temptation and restraint, and problem drinking among college students

PubMed Central

Rinker, Dipali Venkataraman; Neighbors, Clayton

2013-01-01

Temptation and restraint have long been associated with problematic drinking. Among college students, social norms are one of the strongest predictors of problematic drinking. To date, no studies have examined the association between temptation and restraint and perceived descriptive norms on drinking and alcohol-related problems among college students. The purpose of this study was to examine whether perceived descriptive norms moderated the relationship between temptation and restraint and drinking outcomes among college students. Participants were 1,095 college students from a large, public, culturally-diverse, southern university who completed an online survey about drinking behaviors and related attitudes. Drinks per week and alcohol-related problems were examined as a function of perceived descriptive norms, Cognitive Emotional Preoccupation (CEP) (temptation), and Cognitive Behavioral Control (CBC) (restraint). Additionally, drinking outcomes were examined as a function of the two-way interactions between CEP and perceived descriptive norms and CBC and perceived descriptive norms. Results indicated that CEP and perceived descriptive norms were associated with drinking outcomes. CBC was not associated with drinking outcomes. Additionally, perceived descriptive norms moderated the association between CEP and drinks per week and CEP and alcohol-related problems. There was a positive association between CEP and drinks per week and CEP and alcohol-related problems, especially for those higher on perceived descriptive norms. College students who are very tempted to drink may drink more heavily and experience alcohol-related problems more frequently if they have greater perceptions that the typical student at their university/college drinks a lot. PMID:24064190

Social influence on temptation: perceived descriptive norms, temptation and restraint, and problem drinking among college students.

PubMed

Rinker, Dipali Venkataraman; Neighbors, Clayton

2013-12-01

Temptation and restraint have long been associated with problematic drinking. Among college students, social norms are one of the strongest predictors of problematic drinking. To date, no studies have examined the association between temptation and restraint and perceived descriptive norms on drinking and alcohol-related problems among college students. The purpose of this study was to examine whether perceived descriptive norms moderated the relationship between temptation and restraint and drinking outcomes among college students. Participants were 1095 college students from a large, public, culturally-diverse, southern university who completed an online survey about drinking behaviors and related attitudes. Drinks per week and alcohol-related problems were examined as a function of perceived descriptive norms, Cognitive Emotional Preoccupation (CEP) (temptation), and Cognitive Behavioral Control (CBC) (restraint). Additionally, drinking outcomes were examined as a function of the two-way interactions between CEP and perceived descriptive norms and CBC and perceived descriptive norms. Results indicated that CEP and perceived descriptive norms were associated with drinking outcomes. CBC was not associated with drinking outcomes. Additionally, perceived descriptive norms moderated the association between CEP and drinks per week and CEP and alcohol-related problems. There was a positive association between CEP and drinks per week and CEP and alcohol-related problems, especially for those higher on perceived descriptive norms. College students who are very tempted to drink may drink more heavily and experience alcohol-related problems more frequently if they have greater perceptions that the typical student at their university/college drinks a lot. © 2013.

An efficient phosphorus scavenging from aqueous solution using magnesiothermally modified bio-calcite.

PubMed

Ahmad, Munir; Ahmad, Mahtab; Usman, Adel R A; Al-Faraj, Abdullah S; Ok, Yong Sik; Hussain, Qaiser; Abduljabbar, Adel S; Al-Wabel, Mohammad I

2018-07-01

Bio-calcite (BC) derived from waste hen eggshell was subjected to thermal treatments (calcined bio-calcite (CBC)). The BC and CBC were further modified via magnesiothermal treatments to produce modified bio-calcite (MBC) and modified calcined bio-calcite (MCBC), respectively, and evaluated as a novel green sorbent for P removal from aqueous solutions in the batch experiments. Modified BC exhibited improved structural and chemical properties, such as porosity, surface area, thermal stability, mineralogy and functional groups, than pristine material. Langmuir and Freundlich models well described the P sorption onto both thermally and magnesiothermally sorbents, respectively, suggesting mono- and multi-layer sorption. Langmuir predicted highest P sorption capacities were in the order of: MCBC (43.33 mg g -1 ) > MBC (35.63 mg g- 1 ) > CBC (34.38 mg g -1 ) > BC (30.68 mg g -1 ). The MBC and MCBC removed 100% P up to 50 mg P L -1 , which reduced to 35.43 and 39.96%, respectively, when P concentration was increased up to 1000 mg L -1 . Dynamics of P sorption was well explained by the pseudo-second-order rate equation, with the highest sorption rate of 4.32 mg g -1  min -1 for the MCBC. Hydroxylapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] and brushite [CaH(PO 4 )·2H 2 O] were detected after P sorption onto the modified sorbents by X-ray diffraction analysis, suggesting chemisorption as the operating sorption mechanism.

Redox potential as a master variable controlling pathways of metal reduction by Geobacter sulfurreducens

PubMed Central

Levar, Caleb E; Hoffman, Colleen L; Dunshee, Aubrey J; Toner, Brandy M; Bond, Daniel R

2017-01-01

Geobacter sulfurreducens uses at least two different pathways to transport electrons out of the inner membrane quinone pool before reducing acceptors beyond the outer membrane. When growing on electrodes poised at oxidizing potentials, the CbcL-dependent pathway operates at or below redox potentials of –0.10 V vs the standard hydrogen electrode, whereas the ImcH-dependent pathway operates only above this value. Here, we provide evidence that G. sulfurreducens also requires different electron transfer proteins for reduction of a wide range of Fe(III)- and Mn(IV)-(oxyhydr)oxides, and must transition from a high- to low-potential pathway during reduction of commonly studied soluble and insoluble metal electron acceptors. Freshly precipitated Fe(III)-(oxyhydr)oxides could not be reduced by mutants lacking the high-potential pathway. Aging these minerals by autoclaving did not change their powder X-ray diffraction pattern, but restored reduction by mutants lacking the high-potential pathway. Mutants lacking the low-potential, CbcL-dependent pathway had higher growth yields with both soluble and insoluble Fe(III). Together, these data suggest that the ImcH-dependent pathway exists to harvest additional energy when conditions permit, and CbcL switches on to allow respiration closer to thermodynamic equilibrium conditions. With evidence of multiple pathways within a single organism, the study of extracellular respiration should consider not only the crystal structure or solubility of a mineral electron acceptor, but rather the redox potential, as this variable determines the energetic reward affecting reduction rates, extents, and final microbial growth yields in the environment. PMID:28045456

Epidural abscess

MedlinePlus

The health care provider will perform a physical exam to look for a loss of functions, such as movement or sensation. Tests that may be done include: Blood cultures to check for bacteria in the blood Complete blood count ( CBC ) CT scan of head or spine ...

Eosinophilic fasciitis

MedlinePlus

... include: CBC with differential Gamma globulins (a type of immune system protein) Erythrocyte sedimentation rate ( ESR ) MRI Muscle biopsy ... urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is ...

DEMONSTRATION BULLETIN: CIRCULATING BED COMBUSTOR - OGDEN ENVIRONMENTAL SERVICES, INC.

EPA Science Inventory

An evaluation of the Ogden Environmental Services (OES) circulating bed combustor (CBC) technology was carried out under the superfund Innovative Technology Evaluation (SITE) Program to determine its applicabilitY as an on-site treatment method for waste site cleanups, and more s...

Gastritis

MedlinePlus

... Less common causes are: Autoimmune disorders (such as pernicious anemia) Backflow of bile into the stomach (bile reflux) ... causing bleeding from the lining of the stomach, symptoms may include: Black stools Vomiting blood ... Complete blood count (CBC) to check for anemia or low blood count Examination of the stomach ...

A unified approach to χ2 discriminators for searches of gravitational waves from compact binary coalescences

NASA Astrophysics Data System (ADS)

Dhurandhar, Sanjeev; Gupta, Anuradha; Gadre, Bhooshan; Bose, Sukanta

2017-11-01

We describe a general mathematical framework for χ2 discriminators in the context of the compact binary coalescence (CBC) search. We show that with any χ2 is associated a vector bundle over the signal manifold, that is, the manifold traced out by the signal waveforms in the function space of data segments. The χ2 is then defined as the square of the L2 norm of the data vector projected onto a finite-dimensional subspace (the fibre) of the Hilbert space of data trains and orthogonal to the signal waveform. Any such fibre leads to a χ2 discriminator, and the full vector bundle comprising the subspaces and the base manifold constitute the χ2 discriminator. We show that the χ2 discriminators used so far in the CBC searches correspond to different fibre structures constituting different vector bundles on the same base manifold, namely, the parameter space. Several benefits accrue from this general formulation. It most importantly shows that there are a plethora of χ2's available and further gives useful insights into the vetoing procedure. It indicates procedures to formulate new χ2's that could be more effective in discriminating against commonly occurring glitches in the data. It also shows that no χ2 with a reasonable number of degrees of freedom is foolproof. It could also shed light on understanding why the traditional χ2 works so well. We show how to construct a generic χ2 given an arbitrary set of vectors in the function space of data segments. These vectors could be chosen such that glitches have maximum projection on them. Further, for glitches that can be modeled, we are able to quantify the efficiency of a given χ2 discriminator by a probability. Second, we propose a family of ambiguity χ2 discriminators that is an alternative to the traditional one [B. Allen, Phys. Rev. D 71, 062001 (2005), 10.1103/PhysRevD.71.062001, B. Allen et al., Phys. Rev. D 85, 122006 (2012)., 10.1103/PhysRevD.85.122006]. Any such ambiguity χ2 makes use of the filtered output of the template bank, thus adding negligible cost to the overall search. It is termed so because it makes significant use of the ambiguity function. We first describe the formulation with the help of the Newtonian waveform, apply the ambiguity χ2 to the spinless TaylorF2 waveforms, and test it on simulated data. We show that the ambiguity χ2 essentially gives a clean separation between glitches and signals. We indicate how the ambiguity χ2 can be generalized to detector networks for coherent observations. The effects of mismatch between signal and templates on a χ2 discriminator using general arguments and the geometrical framework are also investigated.

Differences in Routine Laboratory Ordering Between a Teaching Service and a Hospitalist Service at a Single Academic Medical Center.

PubMed

Ellenbogen, Michael I; Ma, Madeleine; Christensen, Nicholas P; Lee, Jungwha; O'Leary, Kevin J

2017-01-01

Studies have shown that the overutilization of laboratory tests ("labs") for hospitalized patients is common and can cause adverse health outcomes. Our objective was to compare the ordering tendencies for routine complete blood counts (CBC) and chemistry panels by internal medicine residents and hospitalists. This observational study included a survey of medicine residents and hospitalists and a retrospective analysis of labs ordering data. The retrospective data analysis comprised patients admitted to either the teaching service or nonteaching hospitalist service at a single hospital during 2014. The survey asked residents and hospitalists about their practices and preferences on labs ordering. The frequency and timing of one-time and daily CBC and basic chemistry panel ordering for teaching service and hospitalist patients were obtained from our data warehouse. The average number of CBCs per patient per day and chemistry panels per patient per day was calculated for both services and multivariate regression was performed to control for patient characteristics. Forty-four of 120 (37%) residents and 41 of 53 (77%) hospitalists responded to the survey. Forty-four (100%) residents reported ordering a daily CBC and chemistry panel rather than one-time labs at patient admission compared with 22 (54%) hospitalists ( P < 0.001). For CBCs, teaching service patients averaged 1.72/day and hospitalist service patients averaged 1.43/day ( P < 0.001). For basic chemistry panels, teaching service patients averaged 1.96/day and hospitalist service patients averaged 1.78/day ( P < 0.001). Results were similar in multivariate regression models adjusting for patient characteristics. Residents' self-reported and actual use of CBCs and chemistry panels is significantly higher than that of hospitalists in the same hospital. Our results reveal an opportunity for greater supervision and improved instruction of cost-conscious ordering practices.

Lateral organ boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease

PubMed Central

Hu, Yang; Zhang, Junli; Jia, Hongge; Sosso, Davide; Li, Ting; Frommer, Wolf B.; Yang, Bing; White, Frank F.; Wang, Nian; Jones, Jeffrey B.

2014-01-01

Citrus bacterial canker (CBC) disease occurs worldwide and incurs considerable costs both from control measures and yield losses. Bacteria that cause CBC require one of six known type III transcription activator-like (TAL) effector genes for the characteristic pustule formation at the site of infection. Here, we show that Xanthomonas citri subspecies citri strain Xcc306, with the type III TAL effector gene pthA4 or with the distinct yet biologically equivalent gene pthAw from strain XccAw, induces two host genes, CsLOB1 and CsSWEET1, in a TAL effector-dependent manner. CsLOB1 is a member of the Lateral Organ Boundaries (LOB) gene family of transcription factors, and CsSWEET1 is a homolog of the SWEET sugar transporter and rice disease susceptibility gene. Both TAL effectors drive expression of CsLOB1 and CsSWEET1 promoter reporter gene fusions when coexpressed in citrus or Nicotiana benthamiana. Artificially designed TAL effectors directed to sequences in the CsLOB1 promoter region, but not the CsSWEET1 promoter, promoted pustule formation and higher bacterial leaf populations. Three additional distinct TAL effector genes, pthA*, pthB, and pthC, also direct pustule formation and expression of CsLOB1. Unlike pthA4 and pthAw, pthB and pthC do not promote the expression of CsSWEET1. CsLOB1 expression was associated with the expression of genes associated with cell expansion. The results indicate that CBC-inciting species of Xanthomonas exploit a single host disease susceptibility gene by altering the expression of an otherwise developmentally regulated gene using any one of a diverse set of TAL effector genes in the pathogen populations. PMID:24474801

Lateral organ boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease.

PubMed

Hu, Yang; Zhang, Junli; Jia, Hongge; Sosso, Davide; Li, Ting; Frommer, Wolf B; Yang, Bing; White, Frank F; Wang, Nian; Jones, Jeffrey B

2014-01-28

Citrus bacterial canker (CBC) disease occurs worldwide and incurs considerable costs both from control measures and yield losses. Bacteria that cause CBC require one of six known type III transcription activator-like (TAL) effector genes for the characteristic pustule formation at the site of infection. Here, we show that Xanthomonas citri subspecies citri strain Xcc306, with the type III TAL effector gene pthA4 or with the distinct yet biologically equivalent gene pthAw from strain XccA(w), induces two host genes, CsLOB1 and CsSWEET1, in a TAL effector-dependent manner. CsLOB1 is a member of the Lateral Organ Boundaries (LOB) gene family of transcription factors, and CsSWEET1 is a homolog of the SWEET sugar transporter and rice disease susceptibility gene. Both TAL effectors drive expression of CsLOB1 and CsSWEET1 promoter reporter gene fusions when coexpressed in citrus or Nicotiana benthamiana. Artificially designed TAL effectors directed to sequences in the CsLOB1 promoter region, but not the CsSWEET1 promoter, promoted pustule formation and higher bacterial leaf populations. Three additional distinct TAL effector genes, pthA*, pthB, and pthC, also direct pustule formation and expression of CsLOB1. Unlike pthA4 and pthAw, pthB and pthC do not promote the expression of CsSWEET1. CsLOB1 expression was associated with the expression of genes associated with cell expansion. The results indicate that CBC-inciting species of Xanthomonas exploit a single host disease susceptibility gene by altering the expression of an otherwise developmentally regulated gene using any one of a diverse set of TAL effector genes in the pathogen populations.

Repeated Measurement of the Intermountain Risk Score Enhances Prognostication for Mortality

PubMed Central

Horne, Benjamin D.; Lappé, Donald L.; Muhlestein, Joseph B.; May, Heidi T.; Ronnow, Brianna S.; Brunisholz, Kimberly D.; Kfoury, Abdallah G.; Bunch, T. Jared; Alharethi, Rami; Budge, Deborah; Whisenant, Brian K.; Bair, Tami L.; Jensen, Kurt R.; Anderson, Jeffrey L.

2013-01-01

Background The Intermountain Risk Score (IMRS), composed of the complete blood count (CBC) and basic metabolic profile (BMP), predicts mortality and morbidity in medical and general populations. Whether longitudinal repeated measurement of IMRS is useful for prognostication is an important question for its clinical applicability. Methods Females (N = 5,698) and males (N = 5,437) with CBC and BMP panels measured 6 months to 2.0 years apart (mean 1.0 year) had baseline and follow-up IMRS computed. Survival analysis during 4.0±2.5 years (maximum 10 years) evaluated mortality (females: n = 1,255 deaths; males: n = 1,164 deaths) and incident major events (myocardial infarction, heart failure [HF], and stroke). Results Both baseline and follow-up IMRS (categorized as high-risk vs. low-risk) were independently associated with mortality (all p<0.001) in bivariable models. For females, follow-up IMRS had hazard ratio (HR) = 5.23 (95% confidence interval [CI] = 4.11, 6.64) and baseline IMRS had HR = 3.66 (CI = 2.94, 4.55). Among males, follow-up IMRS had HR = 4.28 (CI = 3.51, 5.22) and baseline IMRS had HR = 2.32 (CI = 1.91, 2.82). IMRS components such as RDW, measured at both time points, also predicted mortality. Baseline and follow-up IMRS strongly predicted incident HF in both genders. Conclusions Repeated measurement of IMRS at baseline and at about one year of follow-up were independently prognostic for mortality and incident HF among initially hospitalized patients. RDW and other CBC and BMP values were also predictive of outcomes. Further research should evaluate the utility of IMRS as a tool for clinical risk adjustment. PMID:23874899

Predicting women's intentions for contralateral prophylactic mastectomy: An application of an extended theory of planned behaviour.

PubMed

Richards, Imogen; Tesson, Stephanie; Porter, David; Phillips, Kelly-Anne; Rankin, Nicole; Musiello, Toni; Marven, Michelle; Butow, Phyllis

2016-04-01

Most women with unilateral breast cancer (BC) without BRCA1/2 gene mutations are at low risk of contralateral breast cancer (CBC). One CBC risk-management option is contralateral prophylactic mastectomy (CPM). While there is no evidence that CPM increases life-expectancy, its uptake is increasing. This study aimed to assess the validity of an extended social-cognition model, the Theory of Planned Behaviour (TPB), in predicting women's intentions to undergo CPM. Four hundred women previously treated for BC completed an online survey exploring demographic and disease factors, attitude, subjective norm, perceived behavioural control, anticipated regret, uncertainty avoidance, self-efficacy to not have CPM and intentions to undergo CPM in a common hypothetical decision-making scenario. The TPB uniquely explained 25.7% of intention variance. Greater anticipated regret, uncertainty avoidance and lower self-efficacy to cope with not having CPM were associated with stronger CPM intentions, explaining an additional 7.7%, 10.6% and 2.9% respectively, of variance over and above the TPB. Women who had undergone CPM, had not attended university, and had children reported stronger CPM intentions. A holistic understanding of CPM decision-making appears to require consideration beyond CBC risk, demographics and disease characteristics, exploring women's expectations about CPM outcomes, others' opinions, and avoidance of emotionality and difficulties associated with not undergoing surgery. This study provides a theoretical basis from which the complexity of CPM decision-making may be understood, and from which resources for patients and treating staff may be developed to support women's informed decision-making aligning with their personal values. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Influence of Varying Cost Formats on Preferences

PubMed Central

Jiang, Charles Changchuan; Fraenkel, Liana

2016-01-01

Background Numerous studies have found that cost strongly influences patients’ decision-making. The objective of this study was to explore the impact of varying cost formats on patients’ preferences. Methods Mechanical Turk workers completed a choice based conjoint (CBC) analysis survey. The CBC survey was designed to examine stated preferences for second line agents used to treat diabetes using five attributes: route of administration, efficacy, risk of low blood sugar, frequency of checking blood sugar levels and cost. We developed seven versions of the CBC survey which were identical except for the cost attribute. We described cost in terms of: Affordability, Monthly co-pay, Dollar Sign Rating, How Expensive or How Cheap compared to other medications, Monthly Co-pay, Working Hours Equivalent (per month) and Percent of Monthly Income. The resulting part-worth utilities were used to calculate the relative importance of cost and to estimate treatment preferences for a sulfonylurea, exenatide and insulin. Results The relative impact of cost varied significantly across the seven formats. Cost had the greatest influence on participants’ decisions when framed in terms of Affordability [mean (SD) relative importance = 37.3 (0.9)] and the lowest influence when framed in terms of How Cheap (compared to other drugs) [mean (SD) relative importance= 12.1 (0.9)]. A sulfonylurea was strongly preferred across four of the seven formats. Preference for insulin, the most effective, albeit riskiest option, was low across all cost formats. Conclusions The format used to describe cost influences how this attribute impacts patients’ preferences. Individuals are most cost-sensitive when cost is framed in terms of affordability and least cost-sensitive when cost is described in terms of how cheap the medication is compared to others. PMID:27856826

Iron Deficiency without Anemia: A Common Yet Under-Recognized Diagnosis in Young Women with Heavy Menstrual Bleeding.

PubMed

Johnson, Stephen; Lang, Abigail; Sturm, Mollie; O'Brien, Sarah H

2016-12-01

To assess the proportion of iron deficiency that is not detected with a screening hemoglobin or complete blood count (CBC) alone in young women with heavy menstrual bleeding. Retrospective review of electronic medical records. Nationwide Children's Hospital in Columbus, Ohio. One hundred fourteen young women aged 9-19 years consecutively referred to a young women's hematology clinic with a complaint of heavy menstrual bleeding. Fifty-eight (50.9%) of all patients had ferritin <20 ng/mL indicating iron deficiency. Of the 58 patients with iron deficiency, only 24 (41.4%) were anemic and 25 (46.3%) were microcytic. The sensitivity of hemoglobin alone and CBC alone for identifying women with ferritin <20 ng/mL was 41.4% (95% confidence interval [CI], 28.7-54.1) and 46.3% (95% CI, 33.0-59.6), respectively. Both tests had reasonable specificity at 91.1% (95% CI, 83.6-98.5) for hemoglobin and 83.9% for CBC (95% CI, 74.3-93.6). Patients had significantly higher odds of having iron deficiency if they were overweight or obese (odds ratio, 2.81; 95% CI, 1.25-6.29) compared with patients with normal body mass index. Age at presentation for heavy menstrual bleeding, presence of an underlying bleeding disorder, and median household income were not significantly associated with iron deficiency. In adolescents with heavy menstrual bleeding, fewer than half of iron deficiency cases are detected when screening is performed with hemoglobin or blood count alone. Measuring ferritin levels in at-risk patients might allow for earlier implementation of iron therapy and improvement in symptoms. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Calculation characteristics of centrifugal compressor operates on a mixture of gases

NASA Astrophysics Data System (ADS)

Novitskiy, B. B.; Arbekov, A. N.

2016-10-01

The creation of Closed Brayton Cycle (CBC) unit is impossible without developing the basic knots. This work is devoted to determining the characteristics of a centrifugal compressor when operating at various working bodies with the help of experimental and numerical studies.

Changing resident test ordering behavior: a multilevel intervention to decrease laboratory utilization at an academic medical center.

PubMed

Vidyarthi, Arpana R; Hamill, Timothy; Green, Adrienne L; Rosenbluth, Glenn; Baron, Robert B

2015-01-01

Hospital laboratory test volume is increasing, and overutilization contributes to errors and costs. Efforts to reduce laboratory utilization have targeted aspects of ordering behavior, but few have utilized a multilevel collaborative approach. The study team partnered with residents to reduce unnecessary laboratory tests and associated costs through multilevel interventions across the academic medical center. The study team selected laboratory tests for intervention based on cost, volume, and ordering frequency (complete blood count [CBC] and CBC with differential, common electrolytes, blood enzymes, and liver function tests). Interventions were designed collaboratively with residents and targeted components of ordering behavior, including system changes, teaching, social marketing, academic detailing, financial incentives, and audit/feedback. Laboratory ordering was reduced by 8% cumulatively over 3 years, saving $2 019 000. By involving residents at every stage of the intervention and targeting multiple levels simultaneously, laboratory utilization was reduced and cost savings were sustained over 3 years. © 2014 by the American College of Medical Quality.

On the importance of controlling for effort in analysis of count survey data: Modeling population change from Christmas Bird Count data

USGS Publications Warehouse

Link, W.A.; Sauer, J.R.; Helbig, Andreas J.; Flade, Martin

1999-01-01

Count survey data are commonly used for estimating temporal and spatial patterns of population change. Since count surveys are not censuses, counts can be influenced by 'nuisance factors' related to the probability of detecting animals but unrelated to the actual population size. The effects of systematic changes in these factors can be confounded with patterns of population change. Thus, valid analysis of count survey data requires the identification of nuisance factors and flexible models for their effects. We illustrate using data from the Christmas Bird Count (CBC), a midwinter survey of bird populations in North America. CBC survey effort has substantially increased in recent years, suggesting that unadjusted counts may overstate population growth (or understate declines). We describe a flexible family of models for the effect of effort, that includes models in which increasing effort leads to diminishing returns in terms of the number of birds counted.

A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes.

PubMed

Penttinen, Leena; Rutanen, Chiara; Saloheimo, Markku; Kruus, Kristiina; Rouvinen, Juha; Hakulinen, Nina

2018-01-01

Coupled binuclear copper (CBC) enzymes have a conserved type 3 copper site that binds molecular oxygen to oxidize various mono- and diphenolic compounds. In this study, we found a new crystal form of catechol oxidase from Aspergillus oryzae (AoCO4) and solved two new structures from two different crystals at 1.8-Å and at 2.5-Å resolutions. These structures showed different copper site forms (met/deoxy and deoxy) and also differed from the copper site observed in the previously solved structure of AoCO4. We also analysed the electron density maps of all of the 56 CBC enzyme structures available in the protein data bank (PDB) and found that many of the published structures have vague copper sites. Some of the copper sites were then re-refined to find a better fit to the observed electron density. General problems in the refinement of metalloproteins and metal centres are discussed.

Distinguishing short duration noise transients in LIGO data to improve the PyCBC search for gravitational waves from high mass binary black hole mergers

NASA Astrophysics Data System (ADS)

Nitz, Alexander H.

2018-02-01

‘Blip glitches’ are a type of short duration transient noise in LIGO data. The cause for the majority of these is currently unknown. Short duration transient noise creates challenges for searches of the highest mass binary black hole systems, as standard methods of applying signal consistency, which look for consistency in the accumulated signal-to-noise of the candidate event, are unable to distinguish many blip glitches from short duration gravitational-wave signals due to similarities in their time and frequency evolution. We demonstrate a straightforward method, employed during Advanced LIGO’s second observing run, including the period of joint observation with the Virgo observatory, to separate the majority of this transient noise from potential gravitational-wave sources. This yields a  ∼20% improvement in the detection rate of high mass binary black hole mergers (> 60 Mȯ ) for the PyCBC analysis.

Quantifying conservation biological control for management of Bemisia tabaci (Hemiptera: Aleyrodidae) in cotton

USDA-ARS?s Scientific Manuscript database

Conservation biological control can be an effective tactic for minimizing insect-induced damage to agricultural production. The most effective manner of applying CBC is through an Integrated Pest Management (IPM) strategy, combining many tactics including cultural controls, pest sampling, the use of...

Conjoint Behavioral Consultation: Community-School Collaboration and Behavioral Outcomes Using Multiple Baseline

ERIC Educational Resources Information Center

Bellinger, Skylar A.; Lee, Steven W.; Jamison, T. Rene; Reese, R. Matthew

2016-01-01

A plethora of literature suggests that collaborative partnerships among families, educators, and outside service providers are necessary and beneficial to address behavior problems, but there continues to be a lack of coordination among these stakeholders. The current study used conjoint behavioral consultation (CBC) to facilitate the development…

Issues in Text Design and Layout for Computer Based Communications.

ERIC Educational Resources Information Center

Andresen, Lee W.

1991-01-01

Discussion of computer-based communications (CBC) focuses on issues involved with screen design and layout for electronic text, based on experiences with electronic messaging, conferencing, and publishing within the Australian Open Learning Information Network (AOLIN). Recommendations for research on design and layout for printed text are also…

A Call for Strategic Planning: The Two-Year College Imperative.

ERIC Educational Resources Information Center

Masoner, David J.; Essex, Nathan, L.

1987-01-01

Addresses the imperative for strategic and tactical planning to support the viability of the two-year college. Describes a process for approaching strategic planning, comprising the following steps: self-identification, self-analysis, analysis of service area, informed decision making, and the development of a marketing plan. (CBC)

Knowledge Exchange between Academia and the Third Sector

ERIC Educational Resources Information Center

Murdock, Alex; Shariff, Razia; Wilding, Karl

2013-01-01

This paper considers the different approaches to undertake knowledge exchange between academia and the third sector from three practitioner perspectives. London South Bank University (LSBU), as part of the Economic and Social Research Council (ESRC) and Third Sector Research Centre (TSRC) Social Enterprise Capacity Building Cluster (CBC), has been…

The effects of Lactobacillus Acidophilus fermentation products as an alternative to antibiotics

USDA-ARS?s Scientific Manuscript database

This experiment compared the effects of Lactobacillus acidophilus fermentation products (LAFP) to carbadox and copper sulfate on growth performance and complete blood counts (CBC). Eight hundred pigs were weaned at 24 d of age and utilized in a randomized block design (4 farrowing groups, blocked by...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowers, Geoffrey M.; Schaef, H. Todd; Loring, John S.

This paper explores the molecular-scale interactions between CO 2 and the representative smectite mineral hectorite under supercritical conditions (90 bar, 50°C) using novel in situ X-ray diffraction (XRD), infrared (IR) spectroscopy, and magic angle spinning (MAS) nuclear magnetic resonance (NMR) techniques. Particular emphasis is placed on understanding the roles of the smectite charge balancing cation (CBC) and H O in these interactions. The data show that supercritical CO 2 (scCO 2) can be adsorbed on external surfaces and in the confined interlayer spaces of hectorite at 50°C and 90 bar, with the uptake of CO 2 into the interlayer favoredmore » at low H 2O content and when the basal spacing is similar to a monolayer hydrate of hectorite (1WL, ~12.5 Å). These results are in agreement with published spectroscopic and molecular modeling data for the related smectite Na-montmorillonite.Charge balancing cations with small radii, large hydration energies, and low polarizabilities tend to scavenge H 2O from humid scCO 2 or retain the H 2O they held before scCO 2 exposure, swelling spontaneously to a bilayer hydrate (2WL) dominated state that largely prevents CO 2-ion interactions and influences the extent of CO 2 intercalation into the interlayer. In contrast, ions with large radii, low hydration energies, and large polarizabilities more readily form close associations with CO 2 with the energetics enabling coexistence of CO 2 and H2O in the interlayer over a wide range of scCO 2 humidities. Integrating our results with those from molecular dynamics simulations of wet CO 2-bearing montmorillonites suggest that adsorbed CO 2 in 1WL-type interlayers is oriented with its long axis parallel to the clay sheets and experiences dynamics dominated by anisotropic rotation about the axis perpendicular to the CO 2 long axis at rates of at least ~105 Hz. If appreciable CO 2 is adsorbed in 2WL-type interlayers, it must experience a mean orientation and dynamic averaging affects that mimic the 1WL-type adsorption environment. External surface adsorbed CO 2 is dynamically similar to the 1WL case, but the CO 2 long axis samples a larger range of orientations with respect to the smectite surface and adopts a different mean angle between the long axis and the smectite surface. Our data also suggest that equilibrating hectorite with a largevolume of scCO 2 at 50°C and 90 bar leads to interlayer dehydration, with the extent of dehydration correlating with the hydrophilicity of the CBC.« less

Continuity & Change in Catholic Education: An Ethnography of Christian Brothers College. Research Monograph No. 1.

ERIC Educational Resources Information Center

Bates, Richard; And Others

Four papers on an ethnographic study of Christian Brothers College (CBC) in Australia, a Catholic college, are presented. In "Christian Brothers College: A View from Overseas," Louis M. Smith discusses research methods, the religious ethos, faculty heterogeneity, diversity in classroom organization, the organizational context of the…

Measures of Risk for Challenging Behaviors: A Comparison between the CBC and BDI

ERIC Educational Resources Information Center

Wert, Barbara Yingling; Bauman, Dona C.; Nottis, Katharyn Ellen Ketter

2010-01-01

A growing body of evidence indicates that for some children, early incidences of challenging behaviors are predictors of later difficulties. These incidences of challenging behaviors may predict mental health issues, social adjustment issues and/or increased challenging behaviors that will impede school success and impact transition to adult life…

Implementing Conjoint Behavioral Consultation for African American Children from a Low-SES, Urban Setting

ERIC Educational Resources Information Center

Ohmstede, Tammi J.; Yetter, Georgette

2015-01-01

This study investigated the effectiveness of conjoint behavioral consultation (CBC) for addressing externalizing behavior concerns in African American children at home and school in a low-socioeconomic status (SES), urban setting. A small-n, multiple-baseline design was employed across participants. Three of the six caregivers were unable to…

Establishing and Maintaining a Catholic Identity: CBC, Class and Newburyport Catholics.

ERIC Educational Resources Information Center

Angus, Lawrence B.

Studies suggest that historically Australian Catholic schools have existed not only to reproduce Catholic traditions, but also to advance the children of the Irish working classes socially. Data collected at the highly academically oriented Christian Brothers College (CBD), Newburyport, support the idea of educating for upward mobility as a means…

The Mediating Effect of Age on the Relationship between Hyperactivity and Neuropsychological Test Performance.

ERIC Educational Resources Information Center

Massman, Paul J.; Nussbaum, Nancy L.

The relationship between hyperactivity and neuropsychological test performance at different age levels was investigated with 90 children 6-8 years old and 92 children 9-12 years old. Subjects were administered a battery of neuropsychological tests, and a parent completed the Child Behavior Checklist (CBC). Young children demonstrated no…

On the Computing Potential of Intracellular Vesicles

PubMed Central

Mayne, Richard; Adamatzky, Andrew

2015-01-01

Collision-based computing (CBC) is a form of unconventional computing in which travelling localisations represent data and conditional routing of signals determines the output state; collisions between localisations represent logical operations. We investigated patterns of Ca2+-containing vesicle distribution within a live organism, slime mould Physarum polycephalum, with confocal microscopy and observed them colliding regularly. Vesicles travel down cytoskeletal ‘circuitry’ and their collisions may result in reflection, fusion or annihilation. We demonstrate through experimental observations that naturally-occurring vesicle dynamics may be characterised as a computationally-universal set of Boolean logical operations and present a ‘vesicle modification’ of the archetypal CBC ‘billiard ball model’ of computation. We proceed to discuss the viability of intracellular vesicles as an unconventional computing substrate in which we delineate practical considerations for reliable vesicle ‘programming’ in both in vivo and in vitro vesicle computing architectures and present optimised designs for both single logical gates and combinatorial logic circuits based on cytoskeletal network conformations. The results presented here demonstrate the first characterisation of intracelluar phenomena as collision-based computing and hence the viability of biological substrates for computing. PMID:26431435

Effect of non-crop vegetation types on conservation biological control of pests in olive groves

PubMed Central

Cayuela, Luis; Gurr, Geoff M.; Campos, Mercedes

2013-01-01

Conservation biological control (CBC) is an environmentally sound potential alternative to the use of chemical insecticides. It involves modifications of the environment to promote natural enemy activity on pests. Despite many CBC studies increasing abundance of natural enemies, there are far fewer demonstrations of reduced pest density and very little work has been conducted in olive crops. In this study we investigated the effects of four forms of non-crop vegetation on the abundance of two important pests: the olive psyllid (Euphyllura olivina) and the olive moth (Prays oleae). Areas of herbaceous vegetation and areas of woody vegetation near olive crops, and smaller patches of woody vegetation within olive groves, decreased pest abundance in the crop. Inter-row ground covers that are known to increase the abundance of some predators and parasitoids had no effect on the pests, possibly as a result of lack of synchrony between pests and natural enemies, lack of specificity or intra-guild predation. This study identifies examples of the right types of diversity for use in conservation biological control in olive production systems. PMID:23904994

[Evaluation of the Abbott Cell-Dyn Sapphire hematology analyzer].

PubMed

Park, Younhee; Song, Jaewoo; Song, Sungwook; Song, Kyung Soon; Ahn, Mee Suk; Yang, Mi-Sook; Kim, Il; Choi, Jong Rak

2007-06-01

The performance of Cell-Dyn Sapphire (Abbott Diagnostic, USA) was compared to the Bayer Advia 2120 (Bayer Diagnostics, USA), Sysmex XE-2100 (Sysmex Corporation, Japan), and reference microscopy. Three hundred samples for routine CBC and WBC differentials were randomly chosen for a comparison analysis. The Cell-Dyn Sapphire system was evaluated according to the linearity, imprecision, inter-instrument correlations, and white blood cell differential. The CBC parameters (WBC, RBC, hemoglobin and platelet) showed a significant linearity with correlation coefficients greater than 0.99 (P<0.0001). Coefficients of variation (CV) for within-run and differential count of WBC were less than 5% except for Total CV for monocytes, eosinophils, and basophils and within-run CV for low valued eosinophils. The correlation coefficients with manual count were lower in monocytes, eosinophils, and basophils than in neutrophils and lymphocytes. The correlation with other hematology anlayzers was significant exclusive of basophils. These results demonstrate that the Cell-Dyn Sapphire has a good linearity, an acceptable reproducibility, a minimal carryover, and a comparable performance with the sysmex XE-2100 and Advia 2120.

A joint encryption/watermarking system for verifying the reliability of medical images.

PubMed

Bouslimi, Dalel; Coatrieux, Gouenou; Cozic, Michel; Roux, Christian

2012-09-01

In this paper, we propose a joint encryption/water-marking system for the purpose of protecting medical images. This system is based on an approach which combines a substitutive watermarking algorithm, the quantization index modulation, with an encryption algorithm: a stream cipher algorithm (e.g., the RC4) or a block cipher algorithm (e.g., the AES in cipher block chaining (CBC) mode of operation). Our objective is to give access to the outcomes of the image integrity and of its origin even though the image is stored encrypted. If watermarking and encryption are conducted jointly at the protection stage, watermark extraction and decryption can be applied independently. The security analysis of our scheme and experimental results achieved on 8-bit depth ultrasound images as well as on 16-bit encoded positron emission tomography images demonstrate the capability of our system to securely make available security attributes in both spatial and encrypted domains while minimizing image distortion. Furthermore, by making use of the AES block cipher in CBC mode, the proposed system is compliant with or transparent to the DICOM standard.

Externalizing behaviors and television viewing in children of low-income minority parents.

PubMed

Gupta, V B; Nwosa, N M; Nadel, T A; Inamdar, S

2001-06-01

The parents of 151 children, ages 4-16 years, attending the pediatric outpatient clinic of an urban hospital were surveyed to determine if aggressive behavior among children of low literacy and low-income parents is related to excessive television viewing or to sociological variables such as ethnicity/race, education, occupation, and parents' marital status. The survey consisted of 22 questions about the ethnicity, marital status, education, and occupation of the parent, the television viewing behavior of the child, and the externalizing behavior scale of the Child Behavior Checklist of Achenbach (CBC). The television viewing habits of children in this study were not significantly different from viewing habits reported in national surveys of the US population. T scores in the aggression scale of CBC were unrelated to the hours of television watched by children and the control of viewing by the parent but were significantly associated with the employment and marital status of the mother. Children of unemployed and single mothers had higher externalizing-behavior scores, suggesting that family ecological variables may have more influence on children's behavior than the duration of television viewing.

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

PubMed Central

Weymann, Alexander; Ali-Hasan-Al-Saegh, Sadeq; Sabashnikov, Anton; Popov, Aron-Frederik; Mirhosseini, Seyed Jalil; Liu, Tong; Lotfaliani, Mohammadreza; de Oliveira Sá, Michel Pompeu Barros; Baker, William L.; Yavuz, Senol; Zeriouh, Mohamed; Jang, Jae-Sik; Dehghan, Hamidreza; Meng, Lei; Testa, Luca; D’Ascenzo, Fabrizio; Benedetto, Umberto; Tse, Gary; Nombela-Franco, Luis; Dohmen, Pascal M.; Deshmukh, Abhishek J.; Linde, Cecilia; Biondi-Zoccai, Giuseppe; Stone, Gregg W.; Calkins, Hugh

2017-01-01

Background Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. Material/Methods We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of −26.39×109/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=−0.005×109/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=−2.71×109/L and p=0.59), WBC (WMD=0.20×109/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). Conclusions Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice. PMID:28496093

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis.

PubMed

Weymann, Alexander; Ali-Hasan-Al-Saegh, Sadeq; Sabashnikov, Anton; Popov, Aron-Frederik; Mirhosseini, Seyed Jalil; Liu, Tong; Lotfaliani, Mohammadreza; Sá, Michel Pompeu Barros de Oliveira; Baker, William L L; Yavuz, Senol; Zeriouh, Mohamed; Jang, Jae-Sik; Dehghan, Hamidreza; Meng, Lei; Testa, Luca; D'Ascenzo, Fabrizio; Benedetto, Umberto; Tse, Gary; Nombela-Franco, Luis; Dohmen, Pascal M; Deshmukh, Abhishek J; Linde, Cecilia; Biondi-Zoccai, Giuseppe; Stone, Gregg W; Calkins, Hugh; Surgery And Cardiology-Group Imcsc-Group, Integrated Meta-Analysis Of Cardiac

2017-05-12

BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.

Effects of Feedstock and Pyrolysis Temperature on Biochar Adsorption of Ammonium and Nitrate

PubMed Central

Gai, Xiapu; Wang, Hongyuan; Liu, Jian; Zhai, Limei; Liu, Shen; Ren, Tianzhi; Liu, Hongbin

2014-01-01

Biochar produced by pyrolysis of biomass can be used to counter nitrogen (N) pollution. The present study investigated the effects of feedstock and temperature on characteristics of biochars and their adsorption ability for ammonium N (NH4 +-N) and nitrate N (NO3 −-N). Twelve biochars were produced from wheat-straw (W-BC), corn-straw (C-BC) and peanut-shell (P-BC) at pyrolysis temperatures of 400, 500, 600 and 700°C. Biochar physical and chemical properties were determined and the biochars were used for N sorption experiments. The results showed that biochar yield and contents of N, hydrogen and oxygen decreased as pyrolysis temperature increased from 400°C to 700°C, whereas contents of ash, pH and carbon increased with greater pyrolysis temperature. All biochars could sorb substantial amounts of NH4 +-N, and the sorption characteristics were well fitted to the Freundlich isotherm model. The ability of biochars to adsorb NH4 +-N followed: C-BC>P-BC>W-BC, and the adsorption amount decreased with higher pyrolysis temperature. The ability of C-BC to sorb NH4 +-N was the highest because it had the largest cation exchange capacity (CEC) among all biochars (e.g., C-BC400 with a CEC of 38.3 cmol kg−1 adsorbed 2.3 mg NH4 +-N g−1 in solutions with 50 mg NH4 + L−1). Compared with NH4 +-N, none of NO3 −-N was adsorbed to biochars at different NO3 − concentrations. Instead, some NO3 −-N was even released from the biochar materials. We conclude that biochars can be used under conditions where NH4 +-N (or NH3) pollution is a concern, but further research is needed in terms of applying biochars to reduce NO3 −-N pollution. PMID:25469875

Mechanism for amorphization of boron carbide B{sub 4}C under uniaxial compression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aryal, Sitaram; Rulis, Paul; Ching, W. Y.

2011-11-01

Boron carbide undergoes an amorphization transition under high-velocity impacts, causing it to suffer a catastrophic loss in strength. The failure mechanism is not clear and this limits the ways to improve its resistance to impact. To help uncover the failure mechanism, we used ab initio methods to carry out large-scale uniaxial compression simulations on two polytypes of stoichiometric boron carbide (B{sub 4}C), B{sub 11}C-CBC, and B{sub 12}-CCC, where B{sub 11}C or B{sub 12} is the 12-atom icosahedron and CBC or CCC is the three-atom chain. The simulations were performed on large supercells of 180 atoms. Our results indicate that themore » B{sub 11}C-CBC (B{sub 12}-CCC) polytype becomes amorphous at a uniaxial strain s = 0.23 (0.22) and with a maximum stress of 168 (151) GPa. In both cases, the amorphous state is the consequence of structural collapse associated with the bending of the three-atom chain. Careful analysis of the structures after amorphization shows that the B{sub 11}C and B{sub 12} icosahedra are highly distorted but still identifiable. Calculations of the elastic coefficients (C{sub ij}) at different uniaxial strains indicate that both polytypes may collapse under a much smaller shear strain (stress) than the uniaxial strain (stress). On the other hand, separate simulations of both models under hydrostatic compression up to a pressure of 180 GPa show no signs of amorphization, in agreement with experimental observation. The amorphized nature of both models is confirmed by detailed analysis of the evolution of the radial pair distribution function, total density of states, and distribution of effective charges on atoms. The electronic structure and bonding of the boron carbide structures before and after amorphization are calculated to further elucidate the mechanism of amorphization and to help form the proper rationalization of experimental observations.« less

Effects of feedstock and pyrolysis temperature on biochar adsorption of ammonium and nitrate.

PubMed

Gai, Xiapu; Wang, Hongyuan; Liu, Jian; Zhai, Limei; Liu, Shen; Ren, Tianzhi; Liu, Hongbin

2014-01-01

Biochar produced by pyrolysis of biomass can be used to counter nitrogen (N) pollution. The present study investigated the effects of feedstock and temperature on characteristics of biochars and their adsorption ability for ammonium N (NH4(+)-N) and nitrate N (NO3(-)-N). Twelve biochars were produced from wheat-straw (W-BC), corn-straw (C-BC) and peanut-shell (P-BC) at pyrolysis temperatures of 400, 500, 600 and 700°C. Biochar physical and chemical properties were determined and the biochars were used for N sorption experiments. The results showed that biochar yield and contents of N, hydrogen and oxygen decreased as pyrolysis temperature increased from 400°C to 700°C, whereas contents of ash, pH and carbon increased with greater pyrolysis temperature. All biochars could sorb substantial amounts of NH4(+)-N, and the sorption characteristics were well fitted to the Freundlich isotherm model. The ability of biochars to adsorb NH4(+)-N followed: C-BC>P-BC>W-BC, and the adsorption amount decreased with higher pyrolysis temperature. The ability of C-BC to sorb NH4(+)-N was the highest because it had the largest cation exchange capacity (CEC) among all biochars (e.g., C-BC400 with a CEC of 38.3 cmol kg(-1) adsorbed 2.3 mg NH4(+)-N g(-1) in solutions with 50 mg NH4(+) L(-1)). Compared with NH4(+)-N, none of NO3(-)-N was adsorbed to biochars at different NO3(-) concentrations. Instead, some NO3(-)-N was even released from the biochar materials. We conclude that biochars can be used under conditions where NH4(+)-N (or NH3) pollution is a concern, but further research is needed in terms of applying biochars to reduce NO3(-)-N pollution.

Complete blood counts, liver function tests, and chest x-rays as routine screening in early-stage breast cancer: value added or just cost?

PubMed

Louie, Raphael J; Tonneson, Jennifer E; Gowarty, Minda; Goodney, Philip P; Barth, Richard J; Rosenkranz, Kari M

2015-11-01

Current National Comprehensive Cancer Network guidelines for breast cancer staging include pre-treatment complete blood count (CBC) and liver function tests (LFT) to screen for occult metastatic disease. To date, the relevance of these tests in detecting metastatic disease in asymptomatic women with early-stage breast cancer (Stage I/II) has not been demonstrated. Although chest x-rays are no longer recommended in the NCCN guidelines, many centers continue to include this imaging as part of their screening process. We aim to determine the clinical and financial impact of these labs and x-rays in the evaluation of early-stage breast cancer patients. A single institution IRB-approved retrospective chart review was conducted of patients with biopsy-proven invasive breast cancer treated from January 1, 2005–December 31, 2009. We collected patient demographics, clinical and pathologic staging, chest x-ray, CBC, and LFT results at the time of referral. Patients were stratified according to radiographic stage at the time of diagnosis. We obtained Medicare reimbursement fees for cost analysis. From 2005 to 2009, 1609 patients with biopsy-proven invasive breast cancer were treated at our institution. Of the 1082 patients with radiographic stage I/II disease, 27.3 % of patients had abnormal CBCs. No additional testing was performed to evaluate these abnormalities. In the early-stage population, 24.7 % of patients had elevated LFTs, resulting in 84 additional imaging studies. No metastatic disease was detected. The cost of CBC, LFTs and chest x-rays was $110.20 per patient, totaling $106,410.99. Additional tests prompted by abnormal results cost $58,143.30 over the five-year period. We found that pre-treatment CBCs, LFTs, and chest x-rays did not improve detection of occult metastatic disease but resulted in additional financial costs. Avoiding routine ordering of these tests would save the US healthcare system $25.7 million annually.

Representing New Math: Genre Chains and Controversy in the Saskatchewan Media

ERIC Educational Resources Information Center

LeBlanc, Robert J.

2012-01-01

The media's response to the release of "Math Instruction that Makes Sense" (2011), a research report by the Frontier Centre for Public Policy (FCPP), helped spark a public controversy and spur the Saskatchewan government to reexamine the Ministry of Education's math curriculum. The purpose of this article is to examine the CBC's…

Application of the Covalent Bond Classification Method for the Teaching of Inorganic Chemistry

ERIC Educational Resources Information Center

Green, Malcolm L. H.; Parkin, Gerard

2014-01-01

The Covalent Bond Classification (CBC) method provides a means to classify covalent molecules according to the number and types of bonds that surround an atom of interest. This approach is based on an elementary molecular orbital analysis of the bonding involving the central atom (M), with the various interactions being classified according to the…

Applying the SWAT hydrologic model on a watershed containing forested karst.

Treesearch

Devendra M. Amatya; Amy E. Edwards

2009-01-01

The US Forest Service Center for Forested Wetlands Research is working on a South Carolina Department of Health and Environmental Control (SC DHEC)'s Section 319 Grant Program funded Total Maximum Daily Load (TMDL) project for the watershed of Chapel Branch Creek (CBC) draining to Lake Marion in Santee, South Carolina (Fig. 1)....

The Effect of Case-Based Curriculum on Cognitive and Affective Characteristics of Students

ERIC Educational Resources Information Center

Ilhan-Beyaztas, Dilek; Özdemir, Burhanettin

2018-01-01

This study aims to determine the effect of case-based curriculum (CBC) on the cognitive and affective characteristics of the pre-service teachers. The case-based curriculum was developed within the scope of the "Introduction to Educational Science" course at the university level. It was applied to experimental groups by two different…

The Role of Attending Center-Based Care for Kindergarten-Aged Children with Disabilities

ERIC Educational Resources Information Center

Gottfried, Michael A.

2017-01-01

Background/Context: Families have been increasingly utilizing center-based care both during prekindergarten as well as before/after school during kindergarten (CBC-K), and the literature has addressed the relative effectiveness of attending the former on early schooling outcomes. However, missing in the field is an analysis of the efficacy of…

Outstanding Science Trade Books for Students K-12

ERIC Educational Resources Information Center

Texley, Juliana

2009-01-01

Today's classrooms have no real walls! Students explore the world on field trips, during virtual journeys on the world wide web, and through the books they read. These pathways help them fly to the ends of the universe to satisfy their scientific curiosity. Again this year, the professionals of the NSTA/CBC Review Panel for Outstanding Science…

The Efficacy of Conjoint Behavioral Consultation in the Home Setting: Outcomes and Mechanisms in Rural Communities

ERIC Educational Resources Information Center

Sheridan, Susan M.; Witte, Amanda L.; Holmes, Shannon; Wu, ChaoRong; Bhatia, Sonya A.; Angell, Samantha

2017-01-01

This study reports the results of a randomized controlled trial examining the effect of Conjoint Behavioral Consultation (CBC), a family-school partnership intervention, on children's behaviors, parents' skills, and parent-teacher relationships in rural community and town settings. Participants were 267 children, 267 parents, and 152 teachers in…

Using Conjoint Behavioral Consultation to Implement Evidence-Based Practices for Students in Low-Income Urban Schools

ERIC Educational Resources Information Center

Garbacz, S. Andrew; Watkins, Natasha D.; Diaz, Yamalis; Barnabas, Ernesto R., Jr.; Schwartz, Billie; Eiraldi, Ricardo

2017-01-01

The purpose of this paper is to demonstrate how Conjoint Behavioral Consultation (CBC) can be used by school behavioral health programs within the Interactive Systems Framework (ISF) as a tool for developing and supporting intervention plans that integrate mental health evidence-based practices (EBPs). External behavioral health consultants…

The Effect of Conjoint Behavioral Consultation Program Related Teaching on Problem Behavior and Communication/Social Skills with a Blind and Autistic Child

ERIC Educational Resources Information Center

Kahveci, Gül; Ataman, Aysegül

2017-01-01

Individuals with disabilities display problem behaviors frequently. This case study presents an analysis of the extent to which one student's pattern of multiple problem behaviors and the potential efficacy of Conjoint Behavioral Consultation (CBC) as a model for linking families, schools, and special education settings to address educational…

The Effect of Teacher's Invitations to Parental Involvement on Children's Externalizing Problem Behaviors: An Examination of a CBC Intervention. CYFS Working Paper No. 2012-3

ERIC Educational Resources Information Center

Coutts, Michael J.; Sheridan, Susan M.; Kwon, Kyongboon; Semke, Carrie A.

2012-01-01

Behavioral problems in childhood are associated with academic difficulties including in-school suspensions, high school dropout, and low academic grades and achievement scores. Students with disruptive behavior problems demonstrate higher rates of social risk factors than their nondisruptive peers, including school maladjustment, antisocial…

Leading and Managing the Competence-Based Curriculum: Conscripts, Volunteers and Champions at Work within the Departmentalised Environment of the Secondary School

ERIC Educational Resources Information Center

Downey, Christopher; Byrne, Jenny; Souza, Ana

2013-01-01

This article presents a sub-set of findings from a research project describing the experience of four case study schools which have implemented a competence-based curriculum (CBC) for students in their first year of secondary education. Secondary schools are highly departmentalised environments with organisational structures based primarily around…

Reading Outstanding International Children's Books

ERIC Educational Resources Information Center

Bond, Ernie

2006-01-01

This article describes the task of creating a list of books that will awaken in readers a desire to know more about the world and those who share it. The author was part of a committee assigned this task in 2005 at the Children's Book Council (CBC) and the United States Board on Books for Young People (USBBY) to compile the first annual…

Evaluation of airborne methyl salicylate for improved conservation biological control of two-spotted spider mite and hop aphid in Oregon hop yards

USDA-ARS?s Scientific Manuscript database

The use of synthetic herbivore-induced plant volatiles (HIPV) to attract natural enemies has received interest as a tool to enhance conservation biological control (CBC). Methyl salicylate (MeSA) is a HIPV that is attractive to several key predators of two-spotted spider mite, Tetranychus urticae K...

Evaluation of airborne methyl salicylate for improved conservation biological control of two-spotted spider mites and hop aphid in Oregon hop yards

USDA-ARS?s Scientific Manuscript database

The use of synthetic herbivore-induced plant volatiles (HIPV) to attract natural enemies has received interest as a tool to enhance conservation biological control (CBC). Methyl salicylate (MeSA) is a HIPV that is attractive to several key predators of two-spotted spider mite, Tetranychus urticae K...

Handbook for Instructors. Guide for Parent Instructors in Parent Education Programs. Columbia Basin College Parent Education Program.

ERIC Educational Resources Information Center

Debban, Barbara, Comp.; And Others

This handbook is designed to explain the structure and the existing regulations and procedures of the programs affiliated with the Parent Education Program at Columbia Basin College (CBC), Washington. Purpose of the program is to give parents the opportunity to increase their understanding of children. Section I addresses the importance of parent…

Automated in-clinic hematology instruments for small animal practitioners: what is available, what can they really do, and how do i make a choice?

PubMed

Welles, Elizabeth G

2012-01-01

To have an in-clinic hematology instrument in your practice and how it is used are decisions that precede the purchase of an instrument. Advantages and limitations of the various instruments should be considered. Initial purchase cost, reagent/disposable costs, costs of training personnel in the use and care of the instrument, and service/repair contract costs need to be considered. Once the decision is made to have an in-office hematology instrument in your practice you should benefit from having nearly immediate CBC data results that enable you to provide better quality medicine, more rapid clinical decisions, more closely monitor patients for complications of disease or response to treatment. It should also generate revenue and allow some of your staff members to expand and develop their technical skills as they learn the nuances of a new diagnostic tool and how to provide you with the most accurate CBC information. In the final assessment, the addition of an in-office hematology instrument should improve the quality and efficiency of the medical care you provide patients and generate additional practice income.

The Nell-1 Growth Factor Stimulates Bone Formation by Purified Human Perivascular Cells

PubMed Central

Zhang, Xinli; Péault, Bruno; Chen, Weiwei; Li, Weiming; Corselli, Mirko; James, Aaron W.; Lee, Min; Siu, Ronald K.; Shen, Pang; Zheng, Zhong; Shen, Jia; Kwak, Jinny; Zara, Janette N.; Chen, Feng; Zhang, Hong; Yin, Zack; Wu, Ben; Ting, Kang

2011-01-01

The search for novel sources of stem cells other than bone marrow mesenchymal stem cells (MSCs) for bone regeneration and repair has been a critical endeavor. We previously established an effective protocol to homogeneously purify human pericytes from multiple fetal and adult tissues, including adipose, bone marrow, skeletal muscle, and pancreas, and identified pericytes as a primitive origin of human MSCs. In the present study, we further characterized the osteogenic potential of purified human pericytes combined with a novel osteoinductive growth factor, Nell-1. Purified pericytes grown on either standard culture ware or human cancellous bone chip (hCBC) scaffolds exhibited robust osteogenic differentiation in vitro. Using a nude mouse muscle pouch model, pericytes formed significant new bone in vivo as compared to scaffold alone (hCBC). Moreover, Nell-1 significantly increased pericyte osteogenic differentiation, both in vitro and in vivo. Interestingly, Nell-1 significantly induced pericyte proliferation and was observed to have pro-angiogenic effects, both in vitro and in vivo. These studies suggest that pericytes are a potential new cell source for future efforts in skeletal regenerative medicine, and that Nell-1 is a candidate growth factor able to induce pericyte osteogenic differentiation. PMID:21615216

Heterogeneity of chromatoid bodies in adult pluripotent stem cells of planarian Dugesia japonica.

PubMed

Kashima, Makoto; Kumagai, Nobuyoshi; Agata, Kiyokazu; Shibata, Norito

2016-02-01

The robust regenerative ability of planarians is known to be dependent on adult pluripotent stem cells called neoblasts. One of the morphological features of neoblasts is cytoplasmic ribonucleoprotein granules (chromatoid bodies: CBs), which resemble germ granules present in germline cells in other animals. Previously, we showed by immuno-electron microscopic analysis that DjCBC-1, a planarian Me31B/Dhh1/DDX6 homologue, which is a component of ribonucleoprotein granules, was localized in CBs in the planarian Dugesia japonica. Also, recently it was reported using another planarian species that Y12 antibody recognizing symmetrical dimethylarginine (sDMA) specifically binds to CBs in which histone mRNA is co-localized. Here, we showed by double immunostaining and RNA interference (RNAi) that DjCBC-1-containing CBs and Y12-immunoreactive CBs are distinct structures, suggesting that CBs are composed of heterogeneous populations. We also found that the Y12-immunoreactive CBs specifically contained a cytoplasmic type of planarian PIWI protein (DjPiwiC). We revealed by RNAi experiments that Y12-immunoreactive CBs may have anti-transposable element activity involving the DjPiwiC protein in the neoblasts. © 2016 Japanese Society of Developmental Biologists.

Enhanced performance of microbial fuel cell with in situ preparing dual graphene modified bioelectrode.

PubMed

Chen, Junfeng; Hu, Yongyou; Tan, Xiaojun; Zhang, Lihua; Huang, Wantang; Sun, Jian

2017-10-01

This study proposed a three-step method to prepare dual graphene modified bioelectrode (D-GM-BE) by in situ microbial-induced reduction of GO and polarity reversion in microbial fuel cell (MFC). Both graphene modified bioanode (GM-BA) and biocathode (GM-BC) were of 3D graphene/biofilm architectures; the viability and thickness of microbial biofilm decreased compared with control bioelectrode (C-BE). The coulombic efficiency (CE) of GM-BA was 2.1 times of the control bioanode (C-BA), which demonstrated higher rate of substrates oxidation; the relationship between peak current and scan rates data meant that GM-BC was of higher efficiency of catalyzing oxygen reduction than the control biocathode (C-BC). The maximum power density obtained in D-GM-BE MFC was 122.4±6.9mWm -2 , the interfacial charge transfer resistance of GM-BA and GM-BC were decreased by 79% and 75.7%. The excellent electrochemical performance of D-GM-BE MFC was attributed to the enhanced extracellular electron transfer (EET) process and catalyzing oxygen reduction. Copyright © 2017 Elsevier Ltd. All rights reserved.

NASA Missions Enabled by Space Nuclear Systems

NASA Technical Reports Server (NTRS)

Scott, John H.; Schmidt, George R.

2009-01-01

This viewgraph presentation reviews NASA Space Missions that are enabled by Space Nuclear Systems. The topics include: 1) Space Nuclear System Applications; 2) Trade Space for Electric Power Systems; 3) Power Generation Specific Energy Trade Space; 4) Radioisotope Power Generation; 5) Radioisotope Missions; 6) Fission Power Generation; 7) Solar Powered Lunar Outpost; 8) Fission Powered Lunar Outpost; 9) Fission Electric Power Generation; and 10) Fission Nuclear Thermal Propulsion.

Clinical Investigation Service Annual Research Progress Report Fiscal Year 1980,

DTIC Science & Technology

1980-10-01

Capillary (Heelstick) and Central ( Venous ) 136 Total White Blood Cell Counts and Differentials in Normal Newborn Infants (0) PHYSICAL MEDICINE...Comparison of Capillary (Heelstick) and Central ( Venous ) Total White Blood Cell Counts and Differentials in Normal Newborn Infants PRINCIPAL INVESTIGATOR...tolerance tests with renal glycosuria shall be evaluated. Day 1: History , physical examination, routine CBC, chest x-ray, STS, regular hospital diet (300 gm

Handbook for Parents Enrolled in Parent Education Cooperative Groups. Columbia Basin College Parent Education Program.

ERIC Educational Resources Information Center

Debban, Barbara, Comp.; And Others

This handbook is intended for parents in the Parent Education Program at Columbia Basin College (CBC), Washington. It is designed to help them learn about their role as a participating parent, as an assistant teacher, as a group member, and as a student in a parent education cooperative group. The importance of parent education is emphasized. A…

Case Report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

DTIC Science & Technology

2009-01-01

CBC, reticulocyte count, G-6-PD determination, Duffy phenotype, ABO and Rh group typing, hemoglobin electrophoresis and erythrocyte sedimentation ... rates and APTT† Cardiovascular disease Hepatic or renal abnormalities Cardiovascular function Immunodeficiency Electrocardiogram Autoimmune...malaria vaccine. Progress has been achieved in the development of P. vivax pre- erythrocytic subunit vaccines such as the circumsporo- zoite (CS) and

National Audubon society's technology initiatives for bird conservation: a summary of application development for the Christmas bird count

Treesearch

Kathy Dale

2005-01-01

Since 1998, Audubon's Christmas Bird Count (CBC) has been supported by an Internet-based data entry application that was initially designed to accommodate the traditional paper-based methods of this long-running bird monitoring program. The first efforts to computerize the data and the entry procedures have informed a planned strategy to revise the current...

Power technologies and the space future

NASA Technical Reports Server (NTRS)

Faymon, Karl A.; Fordyce, J. Stuart; Brandhorst, Henry W., Jr.

1991-01-01

Advancements in space power and energy technologies are critical to serve space development needs and help solve problems on Earth. The availability of low cost power and energy in space will be the hallmark of this advance. Space power will undergo a dramatic change for future space missions. The power systems which have served the U.S. space program so well in the past will not suffice for the missions of the future. This is especially true if the space commercialization is to become a reality. New technologies, and new and different space power architectures and topologies will replace the lower power, low-voltage systems of the past. Efficiencies will be markedly improved, specific powers will be greatly increased, and system lifetimes will be markedly extended. Space power technology is discussed - its past, its current status, and predictions about where it will go in the future. A key problem for power and energy is its cost of affordability. Power must be affordable or it will not serve future needs adequately. This aspect is also specifically addressed.

A Virtual Reality Training Curriculum for Laparoscopic Colorectal Surgery.

PubMed

Beyer-Berjot, Laura; Berdah, Stéphane; Hashimoto, Daniel A; Darzi, Ara; Aggarwal, Rajesh

Training within a competency-based curriculum (CBC) outside the operating room enhances performance during real basic surgical procedures. This study aimed to design and validate a virtual reality CBC for an advanced laparoscopic procedure: sigmoid colectomy. This was a multicenter randomized study. Novice (surgeons who had performed <5 laparoscopic colorectal resections as primary operator), intermediate (between 10 and 20), and experienced surgeons (>50) were enrolled. Validity evidence for the metrics given by the virtual reality simulator, the LAP Mentor, was based on the second attempt of each task in between groups. The tasks assessed were 3 modules of a laparoscopic sigmoid colectomy (medial dissection [MD], lateral dissection [LD], and anastomosis) and a full procedure (FP). Novice surgeons were randomized to 1 of 2 groups to perform 8 further attempts of all 3 modules or FP, for learning curve analysis. Two academic tertiary care centers-division of surgery of St. Mary's campus, Imperial College Healthcare NHS Trust, London and Nord Hospital, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, were involved. Novice surgeons were residents in digestive surgery at St. Mary's and Nord Hospitals. Intermediate and experienced surgeons were board-certified academic surgeons. A total of 20 novice surgeons, 7 intermediate surgeons, and 6 experienced surgeons were enrolled. Evidence for validity based on experience was identified in MD, LD, and FP for time (p = 0.005, p = 0.003, and p = 0.001, respectively), number of movements (p = 0.013, p = 0.005, and p = 0.001, respectively), and path length (p = 0.03, p = 0.017, and p = 0.001, respectively), and only for time (p = 0.03) and path length (p = 0.013) in the anastomosis module. Novice surgeons' performance significantly improved through repetition for time, movements, and path length in MD, LD, and FP. Experienced surgeons' benchmark criteria were defined for all construct metrics showing validity evidence. A CBC in laparoscopic colorectal surgery has been designed. Such training may reduce the learning curve during real colorectal resections in the operating room. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

[Study of continuous quality improvement for clinical laboratory processes via the platform of Hospital Group].

PubMed

Song, Wenqi; Shen, Ying; Peng, Xiaoxia; Tian, Jian; Wang, Hui; Xu, Lili; Nie, Xiaolu; Ni, Xin

2015-05-26

The program of continuous quality improvement in clinical laboratory processes for complete blood count (CBC) was launched via the platform of Beijing Children's Hospital Group in order to improve the quality of pediatric clinical laboratories. Fifteen children's hospitals of Beijing Children's Hospital group were investigated using the method of Chinese adapted continuous quality improvement with PDCA (Plan-Do-Check-Action). The questionnaire survey and inter-laboratory comparison was conducted to find the existing problems, to analyze reasons, to set forth quality targets and to put them into practice. Then, targeted training was conducted to 15 children's hospitals and the second questionnaire survey, self examinations by the clinical laboratories was performed. At the same time, the Group's online internal quality control platform was established. Overall effects of the program were evaluated so that lay a foundation for the next stage of PDCA. Both quality of control system documents and CBC internal quality control scheme for all of clinical laboratories were improved through this program. In addition, standardization of performance verification was also improved, especially with the comparable verification rate of precision and internal laboratory results up to 100%. In terms of instrument calibration and mandatory diagnostic rates, only three out of the 15 hospitals (20%) failed to pass muster in 2014 from 46.67% (seven out of the 15 hospitals) in 2013. The abnormal data of intraday precision variance coefficients of the five CBC indicator parameters (WBC, RBC, Hb, Plt and Hct) of all the 15 laboratories accounted for 1.2% (2/165) in 2014, a marked decrease from 9.6% (14/145) in 2013. While the number of the hospitals using only one horizontal quality control object for daily quality control has dropped to three from five. The 15 hospitals organized a total of 263 times of training in 2014 from 101 times in 2013, up 160%. The quality improvement program for the clinical laboratories launched via the Hospital Group platform can promote the joint development of the pediatric clinical laboratory discipline of all the member hospitals with remarkable improvement results, and the experience is recommendable for further rollout.

The OAST space power program

NASA Technical Reports Server (NTRS)

Bennett, Gary L.

1991-01-01

The NASA Office of Aeronautics and Space Technology (OAST) space power program was established to provide the technology base to meet power system requirements for future space missions, including the Space Station, earth orbiting spacecraft, lunar and planetary bases, and solar system exploration. The program spans photovoltaic energy conversion, chemical energy conversion, thermal energy conversion, power management, thermal management, and focused initiatives on high-capacity power, surface power, and space nuclear power. The OAST space power program covers a broad range of important technologies that will enable or enhance future U.S. space missions. The program is well under way and is providing the kind of experimental and analytical information needed for spacecraft designers to make intelligent decisions about future power system options.

Early commercial demonstration of space solar power using ultra-lightweight arrays

NASA Astrophysics Data System (ADS)

Reed, Kevin; Willenberg, Harvey J.

2009-11-01

Space solar power shows great promise for future energy sources worldwide. Most central power stations operate with power capacity of 1000 MW or greater. Due to launch size limitations and specific power of current, rigid solar arrays, the largest solar arrays that have flown in space are around 50 kW. Thin-film arrays offer the promise of much higher specific power and deployment of array sizes up to several MW with current launch vehicles. An approach to early commercial applications for space solar power to distribute power to charge hand-held, mobile battery systems by wireless power transmission (WPT) from thin-film solar arrays in quasi-stationary orbits will be presented. Four key elements to this prototype will be discussed: (1) Space and near-space testing of prototype wireless power transmission by laser and microwave components including WPT space to space and WPT space to near-space HAA transmission demonstrations; (2) distributed power source for recharging hand-held batteries by wireless power transmission from MW space solar power systems; (3) use of quasi-geostationary satellites to generate electricity and distribute it to targeted areas; and (4) architecture and technology for ultra-lightweight thin-film solar arrays with specific energy exceeding 1 kW/kg. This approach would yield flight demonstration of space solar power and wireless power transmission of 1.2 MW. This prototype system will be described, and a roadmap will be presented that will lead to still higher power levels.

Air & Space Power Journal. Volume 18, Number 2, Summer 2004

DTIC Science & Technology

2004-06-01

those areas for as long as required. To­ gether, global access and global presence are the essence of space power.50 Third , space power is...how the US military organizes, trains, plans, and fights. And we must integrate space power accordingly. Third , space power must be integrated

Space Power Architectures for NASA Missions: The Applicability and Benefits of Advanced Power and Electric Propulsion

NASA Technical Reports Server (NTRS)

Hoffman, David J.

2001-01-01

The relative importance of electrical power systems as compared with other spacecraft bus systems is examined. The quantified benefits of advanced space power architectures for NASA Earth Science, Space Science, and Human Exploration and Development of Space (HEDS) missions is then presented. Advanced space power technologies highlighted include high specific power solar arrays, regenerative fuel cells, Stirling radioisotope power sources, flywheel energy storage and attitude control, lithium ion polymer energy storage and advanced power management and distribution.

Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 1).

PubMed

Wilson, Andrew J; Gunning, Patrick T

2016-04-15

This is the first of a two-part Editorial by the Guest Editors of the ChemBioChem and ChemMedChem joint Special Issue on Protein-Protein Interactions. Part 2 can be accessed via http://dx.doi.org/10.1002/cmdc.201600158; the complete issue can be viewed here: bit.ly/cbcVIppi. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Novel Space-based Solar Power Technologies and Architectures for Earth and Beyond

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Fikes, John C.; O'Neill, Mark J.

2005-01-01

Research, development and studies of novel space-based solar power systems, technologies and architectures for Earth and beyond are needed to reduce the cost of clean electrical power for terrestrial use and to provide a stepping stone for providing an abundance of power in space, i.e., manufacturing facilities, tourist facilities, delivery of power between objects in space, and between space and surface sites. The architectures, technologies and systems needed for space to Earth applications may also be used for in-space applications. Advances in key technologies, i.e., power generation, power management and distribution, power beaming and conversion of beamed power are needed to achieve the objectives of both terrestrial and extraterrestrial applications. Power beaming or wireless power transmission (WPT) can involve lasers or microwaves along with the associated power interfaces. Microwave and laser transmission techniques have been studied with several promising approaches to safe and efficient WPT identified. These investigations have included microwave phased array transmitters, as well as laser transmission and associated optics. There is a need to produce "proof-of-concept" validation of critical WPT technologies for both the near-term, as well as far-term applications. Investments may be harvested in near-term beam safe demonstrations of commercial WPT applications. Receiving sites (users) include ground-based stations for terrestrial electrical power, orbital sites to provide power for satellites and other platforms, future space elevator systems, space vehicle propulsion, and space to surface sites. This paper briefly discusses achieving a promising approach to the solar power generation and beamed power conversion. The approach is based on a unique high-power solar concentrator array called Stretched Lens Array (SLA) for both solar power generation and beamed power conversion. Since both versions (solar and laser) of SLA use many identical components (only the photovoltaic cells need to be different), economies of manufacturing and scale may be realized by using SLA on both ends of the laser power beaming system in a space solar power application. Near-term uses of this SLA-laser-SLA system may include terrestrial and space exploration in near Earth space. Later uses may include beamed power for bases or vehicles on Mars.

Influence of the washing program on the blood processing performance of a continuous autotransfusion device.

PubMed

Yoon, Chiyul; Noh, Seungwoo; Lee, Jung Chan; Ko, Sung Ho; Ahn, Wonsik; Kim, Hee Chan

2014-03-01

The continuous autotransfusion system has been widely used in surgical operations. It is known that if oil is added to blood, and this mixture is then processed by an autotransfusion device, the added oil is removed and reinfusion of fat is prevented by the device. However, there is no detailed report on the influence of the particular washing program selected on the levels of blood components including blood fat after continuous autotransfusion using such a system. Fresh bovine blood samples were processed by a commercial continuous autotransfusion device using the "emergency," "quality," and "high-quality" programs, applied in random order. Complete blood count (CBC) and serum chemistry were analyzed to determine how the blood processing performance of the device changes with the washing program applied. There was no significant difference in the CBC results obtained with the three washing programs. Although all of the blood lipids in the processed blood were decreased compared to those in the blood before processing, the levels of triglyceride, phospholipid, and total cholesterol after processing via the emergency program were significantly higher than those present after processing via the quality and high-quality programs. Although the continuous autotransfusion device provided consistent hematocrit quality, the levels of some blood lipid components showed significant differences among the washing programs.

Effects of combination birth control on estrous behavior in captive western lowland gorillas, Gorilla gorilla gorilla.

PubMed

Sarfaty, Anna; Margulis, Susan W; Atsalis, Sylvia

2012-01-01

Combination birth control pills (CBC) are one of the most common birth control methods used for western lowland gorillas (Gorilla gorilla gorilla) housed in zoos. Since zoos are interested in maintaining as many natural behaviors as possible, it is important to know how contraception may affect social and sexual interactions among group members. Although some data are available regarding the influence of the pill on sexual behavior in human females, no data are available on its effects on gorilla estrous behavior. We examined temporal trends of estrous, aggressive, affiliative, and activity budget data in four females on CBC at the Lincoln Park Zoo in Chicago, IL. Behavioral data were collected using point sampling, all-occurrence records, and one-zero sampling. Estrous behavior occurred in less than 1% of observations. Using all-occurrence and one-zero sampling, estrous behavior occurred more frequently in week one of the cycle than any other week. The focal females exhibited affiliative, aggressive, and activity budget data evenly across their cycles. There were also no temporal trends in proximity to the silverback. Females varied by the types of estrous behavior they exhibited. We give a hormonal explanation for the prevalence of estrous behaviors in week one, and recommendations for effective behavioral sampling of gorilla estrous behavior. © 2011 Wiley Periodicals, Inc.

Nano characterization of gunshot residues from Brazilian ammunition.

PubMed

Melo, Lis G A; Martiny, Andrea; Pinto, André L

2014-07-01

Gunshot residues (GSR) from a total of nine different caliber ammunitions produced in Brazil were analyzed and characterized by transmission (TEM) and scanning electron microscopy (SEM). GSR particles are composed of spherical particles of several micrometers of diameter containing distinct amounts of lead, barium and antimony, along with other organic and inorganic elements arising from the primer, gunpowder, the gun and the bullet itself. This study was carried out to obtain additional information on the properties of GSR nanoparticles originated from different types of regular ammunition produced in Brazil by CBC. Besides the SEM, we have used a TEM, exploring its high magnification capability and ability to explore internal structure and chemical composition of submicron particles. We observed that CBC ammunition generated smaller particles than usually reported for other ammunitions and that the three component particles are not a majority. TEM analysis revealed that GSR are partially composed of sub-micron particles as well. The electron diffraction pattern from these particles confirmed them to be mainly composed of lead oxides crystalline nanoparticles that may be agglomerated into larger particles. Energy dispersive X-ray spectroscopy revealed that most of them were composed of two elements, especially PbSb. Ba was not a common element found in the nanoparticles. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Genomic Insights into the Evolutionary Origin of Xanthomonas axonopodis pv. citri and Its Ecological Relatives

PubMed Central

Midha, Samriti

2014-01-01

Xanthomonas axonopodis pv. citri (Xac) is the causal agent of citrus bacterial canker (CBC) and is a serious problem worldwide. Like CBC, several important diseases in other fruits, such as mango, pomegranate, and grape, are also caused by Xanthomonas pathovars that display remarkable specificity toward their hosts. While citrus and mango diseases were documented more than 100 years ago, the pomegranate and grape diseases have been known only since the 1950s and 1970s, respectively. Interestingly, diseases caused by all these pathovars were noted first in India. Our genome-based phylogenetic studies suggest that these diverse pathogens belong to a single species and these pathovars may be just a group of rapidly evolving strains. Furthermore, the recently reported pathovars, such as those infecting grape and pomegranate, form independent clonal lineages, while the citrus and mango pathovars that have been known for a long time form one clonal lineage. Such an understanding of their phylogenomic relationship has further allowed us to understand major and unique variations in the lineages that give rise to these pathovars. Whole-genome sequencing studies including ecological relatives from their putative country of origin has allowed us to understand the evolutionary history of Xac and other pathovars that infect fruits. PMID:25085494

Exploring phlebotomy technique as a pre-analytical factor in proteomic analyses by mass spectrometry.

PubMed

Penn, Andrew M; Lu, Linghong; Chambers, Andrew G; Balshaw, Robert F; Morrison, Jaclyn L; Votova, Kristine; Wood, Eileen; Smith, Derek S; Lesperance, Maria; del Zoppo, Gregory J; Borchers, Christoph H

2015-12-01

Multiple reaction monitoring mass spectrometry (MRM-MS) is an emerging technology for blood biomarker verification and validation; however, the results may be influenced by pre-analytical factors. This exploratory study was designed to determine if differences in phlebotomy techniques would significantly affect the abundance of plasma proteins in an upcoming biomarker development study. Blood was drawn from 10 healthy participants using four techniques: (1) a 20-gauge IV with vacutainer, (2) a 21-gauge direct vacutainer, (3) an 18-gauge butterfly with vacutainer, and (4) an 18-gauge butterfly with syringe draw. The abundances of a panel of 122 proteins (117 proteins, plus 5 matrix metalloproteinase (MMP) proteins) were targeted by LC/MRM-MS. In addition, complete blood count (CBC) data were also compared across the four techniques. Phlebotomy technique significantly affected 2 of the 11 CBC parameters (red blood cell count, p = 0.010; hemoglobin concentration, p = 0.035) and only 12 of the targeted 117 proteins (p < 0.05). Of the five MMP proteins, only MMP7 was detectable and its concentration was not significantly affected by different techniques. Overall, most proteins in this exploratory study were not significantly influenced by phlebotomy technique; however, a larger study with additional patients will be required for confirmation.

A phase I clinical trial evaluating imatinib mesylate (Gleevec) in tumor-bearing cats.

PubMed

Lachowicz, Joshua L; Post, Gerald S; Brodsky, Edwin

2005-01-01

A phase I clinical trial evaluating the toxicity of orally-administered imatinib mesylate was performed in 9 tumor-bearing cats. Imatinib is a small molecule, tyrosine kinase inhibitor, which selectively blocks the function of overexpressed proteins associated with various malignancies. Cats included in the study had diagnoses of fibrosarcoma, squamous cell carcinoma, and mast cell tumor, and each cat was staged using CBC and serum biochemistry; urinalysis, thoracic radiographs, and abdominal ultrasonography were performed in some cats. Most cats were treated previously by surgery, radiation therapy, chemotherapy, or some combination of these treatments. None of the cats received any concurrent chemotherapy. Six cats were treated with imatinib mesylate at 1-2 mg/kg PO q24h. Dose escalations were made to 2, 4, and 10 mg/kg PO q24h in 5 cats. Two cats started therapy at 10 mg/kg PO q24h, and 1 cat started therapy at 15 mg/kg PO q24h; all 3 cats remained at these dosages. No signs of toxicity, as evaluated by CBC and serum biochemistry, were noted in 8 of the 9 cats, and minimal gastrointestinal toxicity was observed. Due to the low frequency of adverse effects, further evaluation of imatinib is ongoing at a dosage of 10 mg/kg PO q24h.

Association between occupational exposures to pesticides with heterogeneous chemical structures and farmer health in China.

PubMed

Huang, Xusheng; Zhang, Chao; Hu, Ruifa; Li, Yifan; Yin, Yanhong; Chen, Zhaohui; Cai, Jinyang; Cui, Fang

2016-04-27

This study analyzed the associations of farmers' exposure to organophosphates (OPs), organosulfurs (OSs), organonitrogens (ONs) and pyrethroids (PYRs) with parameters of the blood complete counts (CBC), a blood chemistry panel (BCP) and the conventional nerve conduction studies among 224 farmers in China in 2012. Two health examinations and a series of follow-up field surveys were conducted. Multiple linear regression analyses were used to evaluate the associations. The results show considerable associations between multiple groups of pesticides and several CBC parameters, but it was not enough to provide evidence of hematological disorders. The short- and medium-term OPs exposures were mainly associated with liver damage and peripheral nerve impairment, respectively, while OSs exposure might induce liver damage and renal dysfunction. The neurotoxicity of ONs was second only to OPs in addition to its potential liver damage and the induced alterations in glucose. In comparison, the estimated results show that PYRs would be the least toxic in terms of the low-dose application. In conclusion, occupational exposures to pesticides with heterogeneous chemical structures are associated with farmer health in different patterns, and the association between a specific group of pesticides and farmer health also differs between the short- and medium-term exposures.

[Automated hematology analysers and spurious counts Part 3. Haemoglobin, red blood cells, cell count and indices, reticulocytes].

PubMed

Godon, Alban; Genevieve, Franck; Marteau-Tessier, Anne; Zandecki, Marc

2012-01-01

Several situations lead to abnormal haemoglobin measurement or to abnormal red blood cells (RBC) counts, including hyperlipemias, agglutinins and cryoglobulins, haemolysis, or elevated white blood cells (WBC) counts. Mean (red) cell volume may be also subject to spurious determination, because of agglutinins (mainly cold), high blood glucose level, natremia, anticoagulants in excess and at times technological considerations. Abnormality related to one measured parameter eventually leads to abnormal calculated RBC indices: mean cell haemoglobin content is certainly the most important RBC parameter to consider, maybe as important as flags generated by the haematology analysers (HA) themselves. In many circumstances, several of the measured parameters from cell blood counts (CBC) may be altered, and the discovery of a spurious change on one parameter frequently means that the validity of other parameters should be considered. Sensitive flags allow now the identification of several spurious counts, but only the most sophisticated HA have optimal flagging, and simpler ones, especially those without any WBC differential scattergram, do not share the same capacity to detect abnormal results. Reticulocytes are integrated into the CBC in many HA, and several situations may lead to abnormal counts, including abnormal gating, interference with intraerythrocytic particles, erythroblastosis or high WBC counts.

Survey of spatial distribution of vector-borne disease in neighborhood dogs in southern Brazil.

PubMed

Constantino, Caroline; de Paula, Edson Ferraz Evaristo; Brandão, Ana Pérola Drulla; Ferreira, Fernando; Vieira, Rafael Felipe da Costa; Biondo, Alexander Welker

2017-01-01

Neighborhood dogs may act as reservoirs and disseminators of vector-borne diseases in urban areas. Accordingly, the aim of this study was to ascertain the health status and the vector-borne pathogens infecting dogs living in public areas with high levels of human movement in the city of Curitiba, southern Brazil. Blood samples from 21 neighborhood dogs that were found in nine of 22 bus stations and two public parks were subjected to a complete blood cell (CBC) count, serum biochemical profiling, a commercial rapid ELISA test and a commercial real-time PCR panel of vector-borne diseases. The CBC count and serum biochemical profiling were within the normal range for dogs and only 1/21 (4.7%) of the dogs was seroreactive for Borrelia burgdorferi sensu stricto. The commercial real-time PCR panel showed that 7/21 (33.3%) of the dogs had Mycoplasma haemocanis infection, 9/21 (42.8%) had ' Candidatus Mycoplasma haematoparvum' and 4/21 (19.0%) had both. No statistical association between infected by the agents found here and abnormalities in physical examinations, laboratory tests or ectoparasite presence was found ( p > 0.05). In conclusion, neighborhood dogs showed low prevalence of vector-borne diseases and satisfactory wellbeing, and dogs can be used as sentinels for disease exposure.

Is power-space a continuum? Distance effect during power judgments.

PubMed

Jiang, Tianjiao; Zhu, Lei

2015-12-01

Despite the increasing evidence suggesting that power processing can activate vertical space schema, it still remains unclear whether this power-space is dichotomic or continuous. Here we tested the nature of the power-space by the distance effect, a continuous property of space cognition. In two experiments, participants were required to judge the power of one single word (Experiment 1) or compare the power of two words presented in pairs (Experiment 2). The power distance was indexed by the absolute difference of power ratings. Results demonstrated that reaction time decreased with the power distance, whereas accuracy increased with the power distance. The findings indicated that different levels of power were presented as different vertical heights, implying that there was a common mechanism underlying space and power cognition. Copyright © 2015 Elsevier Inc. All rights reserved.

Space Power

NASA Technical Reports Server (NTRS)

1984-01-01

Appropriate directions for the applied research and technology programs that will develop space power systems for U.S. future space missions beyond 1995 are explored. Spacecraft power supplies; space stations, space power reactors, solar arrays, thermoelectric generators, energy storage, and communication satellites are among the topics discussed.

Tuberculous spondylitis diagnosed through Xpert MTB/RIF assay in urine: a case report.

PubMed

Sikalengo, George; Ramirez, Adria; Faini, Diana; Mwamelo, Kim; Battegay, Manuel; Jugheli, Levan; Hatz, Christoph; Reither, Klaus; Letang, Emilio

2016-09-26

Extrapulmonary tuberculosis (EPTB) is associated with high rates of morbidity and mortality. Diagnosis of EPTB is challenging in resource-limited settings due to difficulties in obtaining samples, as well as the paucibacillarity of the specimens. Skeletal tuberculosis accounts for 10-35 % of EPTB cases, with vertebral osteomyelitis (Pott's disease) representing 50 % of the cases. We present two cases of suspected Pott's disease, diagnosed through GeneXpert MTB/RIF assay in urine at a rural Tanzanian hospital. Case I A 49-year old male, HIV-1 positive, on co-formulated tenofovir disoproxil fumarate/lamivudine/efavirenz since 2009 and CD4 counts of 205 cells/μL (13 %). He presented with lower back pain and progressive lower limb weakness for two weeks prior to admission. The physical examination revealed bilateral flaccid paraplegia with reduced reflexes, but otherwise unremarkable findings. A lateral lumbar X-ray showed noticeable reduction of intervertebral space between L4 and L5, and a small calcification in the anterior longitudinal ligament between L4 and L5, being compatible with focal spondylosis deformans but inconclusive with regard to tuberculous spondylitis. An abdominal ultrasound showed normal kidneys, bladder and prostate gland. The urinalysis and complete blood counts (CBC) were normal. M. Tuberculosis was detected through GeneXpert MTB/RIF in centrifuged urine, with no resistance to rifampicin. Case II A 76-year old female, HIV-1 negative, presented with lower back pain and progressive weakness and numbness of the lower limbs for two months prior to admission. The physical examination revealed paraplegia, but otherwise unremarkable findings. The lumbosacral X-ray findings were compatible with spondylosis deformans of the lumbar spine and possible tuberculous spondylitis in L3-L4. The abdominal and renal ultrasound showed normal kidneys and bladder. The urinalysis and CBC were normal. M. Tuberculosis was detected through GeneXpert MTB/RIF in centrifuged urine, with no resistance to rifampicin. We report two cases of suspected tuberculous spondylitis diagnosed through Xpert MTB/RIF in urine samples from a rural Tanzanian hospital. Urine testing using Xpert MTB/RIF reflects disseminated disease and renal involvement, and may offer a feasible additional diagnostic approach for Pott's disease in rural Africa.

SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 3: Space power and thermal management

NASA Technical Reports Server (NTRS)

1991-01-01

Viewgraphs of briefings from the SSTAC/ARTS review of the draft integrated technology plan on thermal power and thermal management are presented. Topics covered include: space energy conversion research and technology; space photovoltaic energy conversion; chemical energy conversion and storage; thermal energy conversion; power management; thermal management; space nuclear power; high capacity power; surface power and thermal management; space platforms power and thermal management; and project SELENE.

SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 3: Space power and thermal management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Viewgraphs of briefings from the SSTAC/ARTS review of the draft integrated technology plan on thermal power and thermal management are presented. Topics covered include: space energy conversion research and technology; space photovoltaic energy conversion; chemical energy conversion and storage; thermal energy conversion; power management; thermal management; space nuclear power; high capacity power; surface power and thermal management; space platforms power and thermal management; and project SELENE.

Space nuclear power systems; Proceedings of the 8th Symposium, Albuquerque, NM, Jan. 6-10, 1991. Pts. 1-3

NASA Technical Reports Server (NTRS)

El-Genk, Mohamed S. (Editor); Hoover, Mark D. (Editor)

1991-01-01

The present conference discusses NASA mission planning for space nuclear power, lunar mission design based on nuclear thermal rockets, inertial-electrostatic confinement fusion for space power, nuclear risk analysis of the Ulysses mission, the role of the interface in refractory metal alloy composites, an advanced thermionic reactor systems design code, and space high power nuclear-pumped lasers. Also discussed are exploration mission enhancements with power-beaming, power requirement estimates for a nuclear-powered manned Mars rover, SP-100 reactor design, safety, and testing, materials compatibility issues for fabric composite radiators, application of the enabler to nuclear electric propulsion, orbit-transfer with TOPAZ-type power sources, the thermoelectric properties of alloys, ruthenium silicide as a promising thermoelectric material, and innovative space-saving device for high-temperature piping systems. The second volume of this conference discusses engine concepts for nuclear electric propulsion, nuclear technologies for human exploration of the solar system, dynamic energy conversion, direct nuclear propulsion, thermionic conversion technology, reactor and power system control, thermal management, thermionic research, effects of radiation on electronics, heat-pipe technology, radioisotope power systems, and nuclear fuels for power reactors. The third volume discusses space power electronics, space nuclear fuels for propulsion reactors, power systems concepts, space power electronics systems, the use of artificial intelligence in space, flight qualifications and testing, microgravity two-phase flow, reactor manufacturing and processing, and space and environmental effects.

Space Power: A Theory for Sustaining US Security Through the Information Age

DTIC Science & Technology

2011-05-19

theory in the following manner. First, the great power and major power concepts are presented as tools to analyze the impact of activities in the space...exploration, space enablers, and the space protection concept to fill the gap of current space power theory. Understanding historical power theory...and concept development. Several influential space theorists have provided creative ideas, thoughtful narrative, and generated useful discussion

Power components for the Space Station 20-kHz power distribution system

NASA Technical Reports Server (NTRS)

Renz, David D.

1988-01-01

Since 1984, NASA Lewis Research Center was developing high power, high frequency space power components as part of The Space Station Advanced Development program. The purpose of the Advanced Development program was to accelerate existing component programs to ensure their availability for use on the Space Station. These components include a rotary power transfer device, remote power controllers, remote bus isolators, high power semiconductor, a high power semiconductor package, high frequency-high power cable, high frequency-high power connectors, and high frequency-high power transformers. All the components were developed to the prototype level and will be installed in the Lewis Research Center Space Station power system test bed.

Power components for the space station 20-kHz power distribution system

NASA Technical Reports Server (NTRS)

Renz, David D.

1988-01-01

Since 1984, NASA Lewis Research Center was developing high power, high frequency space power components as part of The Space Station Advanced Development program. The purpose of The Advanced Development program was to accelerate existing component programs to ensure their availability for use on the Space Station. These components include a rotary power transfer device, remote power controllers, remote bus isolators, high power semiconductor, a high power semiconductor package, high frequency-high power cable, high frequency-high power connectors, and high frequency-high power transformers. All the components were developed to the prototype level and will be installed in the Lewis Research Center Space Station power system test bed.

Space Solar Power Satellite Technology Development at the Glenn Research Center: An Overview

NASA Technical Reports Server (NTRS)

Dudenhoefer, James E.; George, Patrick J.

2000-01-01

NASA Glenn Research Center (GRC). is participating in the Space Solar Power Exploratory Research and Technology program (SERT) for the development of a solar power satellite concept. The aim of the program is to provide electrical power to Earth by converting the Sun's energy and beaming it to the surface. This paper will give an overall view of the technologies being pursued at GRC including thin film photovoltaics, solar dynamic power systems, space environmental effects, power management and distribution, and electric propulsion. The developmental path not only provides solutions to gigawatt sized space power systems for the future, but provides synergistic opportunities for contemporary space power architectures. More details of Space Solar Power can be found by reading the references sited in this paper and by connecting to the web site http://moonbase.msfc.nasa.gov/ and accessing the "Space Solar Power" section "Public Access" area.

Historical overview of the US use of space nuclear power

NASA Technical Reports Server (NTRS)

Bennett, Gary L.

1989-01-01

Since 1961, the United States has successfully flown 35 space nuclear power sources on 20 space systems. These space systems have included the Apollo, Pioneer, Viking and Voyager spacecraft launched by the National Aeronautics and Space Administration and navigation and communications satellites launched by the Department of Defense. These power sources performed as planned and i8n many cases exceeded their power requirements and/or lifetimes. All of the power sources met their safety requirements. This paper surveys past uses of space nuclear power in the US and thus serves as a historical framework for other papers in this Conference dealing with future US applications of space nuclear power.

Space nuclear power systems; Proceedings of the 8th Symposium, Albuquerque, NM, Jan. 6-10, 1991. Pts. 1-3

NASA Astrophysics Data System (ADS)

El-Genk, Mohamed S.; Hoover, Mark D.

1991-07-01

The present conference discusses NASA mission planning for space nuclear power, lunar mission design based on nuclear thermal rockets, inertial-electrostatic confinement fusion for space power, nuclear risk analysis of the Ulysses mission, the role of the interface in refractory metal alloy composites, an advanced thermionic reactor systems design code, and space high power nuclear-pumped lasers. Also discussed are exploration mission enhancements with power-beaming, power requirement estimates for a nuclear-powered manned Mars rover, SP-100 reactor design, safety, and testing, materials compatibility issues for fabric composite radiators, application of the enabler to nuclear electric propulsion, orbit-transfer with TOPAZ-type power sources, the thermoelectric properties of alloys, ruthenium silicide as a promising thermoelectric material, and innovative space-saving device for high-temperature piping systems. The second volume of this conference discusses engine concepts for nuclear electric propulsion, nuclear technologies for human exploration of the solar system, dynamic energy conversion, direct nuclear propulsion, thermionic conversion technology, reactor and power system control, thermal management, thermionic research, effects of radiation on electronics, heat-pipe technology, radioisotope power systems, and nuclear fuels for power reactors. The third volume discusses space power electronics, space nuclear fuels for propulsion reactors, power systems concepts, space power electronics systems, the use of artificial intelligence in space, flight qualifications and testing, microgravity two-phase flow, reactor manufacturing and processing, and space and environmental effects. (For individual items see A93-13752 to A93-13937)

Energy from space; Proceedings of the Symposium on Solar Energy from Space, Vienna, Austria, August 9-21, 1982

NASA Astrophysics Data System (ADS)

Freeman, J. W.

Aspects of solar power generation in space are considered. The subjects discussed include: a vision of future energy from space; solar power satellite concept for utilization of energy from space; the institutional challenge of solar power satellites; system study of the solar power satellite concept; market potential and possible limitations for satellite solar power stations; financing a solar power satellite project; and European questions related to satellite power systems. Also addressed are: options and high payoff choices for transportation; an electric propulsion transportation system from low-earth orbit to geostationary orbit utilizing beamed microwave power; the Canadarm robot arm of the Shuttle Remote Manipulator System; an early experimental solar power satellite; power economical considerations for the integration of terrestrial and extraterrestrial solar generators into existing power generation stations; and space solar power in perspective. For individual items see A84-21477 to A84-21489

Verbal-spatial and visuospatial coding of power-space interactions.

PubMed

Dai, Qiang; Zhu, Lei

2018-05-10

A power-space interaction, which denotes the phenomenon that people responded faster to powerful words when they are placed higher in a visual field and faster to powerless words when they are placed lower in a visual field, has been repeatedly found. The dominant explanation of this power-space interaction is that it results from a tight correspondence between the representation of power and visual space (i.e., a visuospatial coding account). In the present study, we demonstrated that the interaction between power and space could be also based on a verbal-spatial coding in absence of any vertical spatial information. Additionally, the verbal-spatial coding was dominant in driving the power-space interaction when verbal space was contrasted with the visual space. Copyright © 2018 Elsevier Inc. All rights reserved.

System impacts of solar dynamic and growth power systems on space station

NASA Technical Reports Server (NTRS)

Farmer, J. T.; Cuddihy, W. F.; Lovelace, U. M.; Badi, D. M.

1986-01-01

Concepts for the 1990's space station envision an initial operational capability with electrical power output requirements of approximately 75 kW and growth power requirements in the range of 300 kW over a period of a few years. Photovoltaic and solar dynamic power generation techniques are contenders for supplying this power to the space station. A study was performed to identify growth power subsystem impacts on other space station subsystems. Subsystem interactions that might suggest early design changes for the space station were emphasized. Quantitative analyses of the effects of power subsystem mass and projected area on space station controllability and reboost requirements were conducted for a range of growth station configurations. Impacts on space station structural dynamics as a function of power subsystem growth were also considered.

Fiber optic microsensor hydrogen leak detection system on Delta IV launch vehicle

NASA Astrophysics Data System (ADS)

Kazemi, Alex A.; Goepp, John W.; Larson, David B.; Wuestling, Mark E.

2008-04-01

This paper describes the successful development and test of a multipoint fiber optic hydrogen microsensors system during the static firing of an Evolved Expandable Launch Vehicle (EELV)/Delta's common booster core (CBC) rocket engine at NASA's Stennis Space Center. The hydrogen sensitive chemistry is fully reversible and has demonstrated a response to hydrogen gas in the range of 0% to 10% with a resolution of 0.1% and a response time of <=5 seconds measured at a gas flow rate of 1 cc/min. The system consisted of a reversible chemical interaction causing a change in reflective of a thin film of coated Palladium. The sensor using a passive element consisting of chemically reactive microcoatings deposited on the surface of a glass microlens, which is then bonded to an optical fiber. The system uses a multiplexing technique with a fiber optic driver-receiver consisting of a modulated LED source that is launched into the sensor, and photodiode detector that synchronously measures the reflected signal. The system incorporates a microprocessor to perform the data analysis and storage, as well as trending and set alarm function. The paper illustrates the sensor design and performance data under field deployment conditions.

Control algorithms and applications of the wavefront sensorless adaptive optics

NASA Astrophysics Data System (ADS)

Ma, Liang; Wang, Bin; Zhou, Yuanshen; Yang, Huizhen

2017-10-01

Compared with the conventional adaptive optics (AO) system, the wavefront sensorless (WFSless) AO system need not to measure the wavefront and reconstruct it. It is simpler than the conventional AO in system architecture and can be applied to the complex conditions. Based on the analysis of principle and system model of the WFSless AO system, wavefront correction methods of the WFSless AO system were divided into two categories: model-free-based and model-based control algorithms. The WFSless AO system based on model-free-based control algorithms commonly considers the performance metric as a function of the control parameters and then uses certain control algorithm to improve the performance metric. The model-based control algorithms include modal control algorithms, nonlinear control algorithms and control algorithms based on geometrical optics. Based on the brief description of above typical control algorithms, hybrid methods combining the model-free-based control algorithm with the model-based control algorithm were generalized. Additionally, characteristics of various control algorithms were compared and analyzed. We also discussed the extensive applications of WFSless AO system in free space optical communication (FSO), retinal imaging in the human eye, confocal microscope, coherent beam combination (CBC) techniques and extended objects.

Overview study of Space Power Technologies for the advanced energetics program. [spacecraft

NASA Technical Reports Server (NTRS)

Taussig, R.; Gross, S.; Millner, A.; Neugebauer, M.; Phillips, W.; Powell, J.; Schmidt, E.; Wolf, M.; Woodcock, G.

1981-01-01

Space power technologies are reviewed to determine the state-of-the-art and to identify advanced or novel concepts which promise large increases in performance. The potential for incresed performance is judged relative to benchmarks based on technologies which have been flight tested. Space power technology concepts selected for their potentially high performance are prioritized in a list of R & D topical recommendations for the NASA program on Advanced Energetics. The technology categories studied are solar collection, nuclear power sources, energy conversion, energy storage, power transmission, and power processing. The emphasis is on electric power generation in space for satellite on board electric power, for electric propulsion, or for beamed power to spacecraft. Generic mission categories such as low Earth orbit missions and geosynchronous orbit missions are used to distinguish general requirements placed on the performance of power conversion technology. Each space power technology is judged on its own merits without reference to specific missions or power systems. Recommendations include 31 space power concepts which span the entire collection of technology categories studied and represent the critical technologies needed for higher power, lighter weight, more efficient power conversion in space.

Free-piston Stirling technology for space power

NASA Technical Reports Server (NTRS)

Slaby, Jack G.

1989-01-01

An overview is presented of the NASA Lewis Research Center free-piston Stirling engine activities directed toward space power. This work is being carried out under NASA's new Civil Space Technology Initiative (CSTI). The overall goal of CSTI's High Capacity Power element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space missions. The Stirling cycle offers an attractive power conversion concept for space power needs. Discussed here is the completion of the Space Power Demonstrator Engine (SPDE) testing-culminating in the generation of 25 kW of engine power from a dynamically-balanced opposed-piston Stirling engine at a temperature ratio of 2.0. Engine efficiency was approximately 22 percent. The SPDE recently has been divided into two separate single-cylinder engines, called Space Power Research Engine (SPRE), that now serve as test beds for the evaluation of key technology disciplines. These disciplines include hydrodynamic gas bearings, high-efficiency linear alternators, space qualified heat pipe heat exchangers, oscillating flow code validation, and engine loss understanding.

Rainfall-runoff modeling of the Chapel Branch Creek Watershed using GIS-based rational and SCS-CN methods

Treesearch

Elizabeth N. Mihalik; Norm S. Levine; Devendra M. Amatya

2008-01-01

Chapel Branch Creek (CBC), located within the Town of Santee adjacent to Lake Marion in Orangeburg County, SC, is listed on the SC 2004 303(d) list of impaired waterbodies due to elevated levels of nitrogen (N), phosphorus (P), chlorophyll-a, and pH. In this study, using a GIS-based approach, two runoff modeling methods, the Rational and SCS-CN methods, have been...

1-Alpha Hydroxyvitamin D(5) as a Chemotherapeutic and Possibly Chemopreventive Agent

DTIC Science & Technology

2007-03-01

Moriarity (Emeritus Professor of Chemistry , University of Illinois at Chicago), in whose laboratory Vitamin D5 analog was synthesized, along with four...made in the FDA’s requirements pertaining to chemistry and stability studies. Below is attached the letter I have just received from Marillion...CBC) with differential, platelets, PT, and PTT. 7.1.4 Serum chemistries : glucose, electrolytes (Na+, K+, Cl-, CO2), BUN, creatinine, total

Historical and projected power requirements

NASA Technical Reports Server (NTRS)

Wolfe, M. G.

1978-01-01

Policy planning for projected space power requirements is discussed. Topics of discussion cover: (1) historical space power trends (prime power requirements and power system costs); and (2) two approaches to future space power requirements (mission/traffic model approach and advanced system scenario approach). Graphs, tables, and flow charts are presented.

Enabling the space exploration initiative: NASA's exploration technology program in space power

NASA Technical Reports Server (NTRS)

Bennett, Gary L.; Cull, Ronald C.

1991-01-01

Space power requirements for Space Exploration Initiative (SEI) are reviewed, including the results of a NASA 90-day study and reports by the National Research Council, the American Institute of Aeronautics and Astronautics (AIAA), NASA, the Advisory Committee on the Future of the U.S. Space Program, and the Synthesis Group. The space power requirements for the SEI robotic missions, lunar spacecraft, Mars spacecraft, and human missions are summarized. Planning for exploration technology is addressed, including photovoltaic, chemical and thermal energy conversion; high-capacity power; power and thermal management for the surface, Earth-orbiting platform and spacecraft; laser power beaming; and mobile surface systems.

A modular Space Station/Base electrical power system - Requirements and design study.

NASA Technical Reports Server (NTRS)

Eliason, J. T.; Adkisson, W. B.

1972-01-01

The requirements and procedures necessary for definition and specification of an electrical power system (EPS) for the future space station are discussed herein. The considered space station EPS consists of a replaceable main power module with self-contained auxiliary power, guidance, control, and communication subsystems. This independent power source may 'plug into' a space station module which has its own electrical distribution, control, power conditioning, and auxiliary power subsystems. Integration problems are discussed, and a transmission system selected with local floor-by-floor power conditioning and distribution in the station module. This technique eliminates the need for an immediate long range decision on the ultimate space base power sources by providing capability for almost any currently considered option.

OAST Space Theme Workshop. Volume 3: Working group summary. 6: Power (P-2). A. Statement. B. Technology needs (form 1). C. Priority assessment (form 2)

NASA Technical Reports Server (NTRS)

1976-01-01

Power requirements for the multipurpose space power platform, for space industrialization, SETI, the solar system exploration facility, and for global services are assessed for various launch dates. Priorities and initiatives for the development of elements of space power systems are described for systems using light power input (solar energy source) or thermal power input, (solar, chemical, nuclear, radioisotopes, reactors). Systems for power conversion, power processing, distribution and control are likewise examined.

Advanced Power System Analysis Capabilities

NASA Technical Reports Server (NTRS)

1997-01-01

As a continuing effort to assist in the design and characterization of space power systems, the NASA Lewis Research Center's Power and Propulsion Office developed a powerful computerized analysis tool called System Power Analysis for Capability Evaluation (SPACE). This year, SPACE was used extensively in analyzing detailed operational timelines for the International Space Station (ISS) program. SPACE was developed to analyze the performance of space-based photovoltaic power systems such as that being developed for the ISS. It is a highly integrated tool that combines numerous factors in a single analysis, providing a comprehensive assessment of the power system's capability. Factors particularly critical to the ISS include the orientation of the solar arrays toward the Sun and the shadowing of the arrays by other portions of the station.

Fuel cell energy storage for Space Station enhancement

NASA Technical Reports Server (NTRS)

Stedman, J. K.

1990-01-01

Viewgraphs on fuel cell energy storage for space station enhancement are presented. Topics covered include: power profile; solar dynamic power system; photovoltaic battery; space station energy demands; orbiter fuel cell power plant; space station energy storage; fuel cell system modularity; energy storage system development; and survival power supply.

Power systems for production, construction, life support and operations in space

NASA Technical Reports Server (NTRS)

Sovie, Ronald J.

1988-01-01

As one looks to man's future in space it becomes obvious that unprecedented amounts of power are required for the exploration, colonization, and exploitation of space. Activities envisioned include interplanetary travel and LEO to GEO transport using electric propulsion, Earth and lunar observatories, advance space stations, free-flying manufacturing platforms, communications platforms, and eventually evolutionary lunar and Mars bases. These latter bases would start as camps with modest power requirements (kWes) and evolve to large bases as manufacturing, food production, and life support materials are developed from lunar raw materials. These latter activities require very robust power supplies (MWes). The advanced power system technologies being pursued by NASA to fulfill these future needs are described. Technologies discussed will include nuclear, photovoltaic, and solar dynamic space power systems, including energy storage, power conditioning, power transmission, and thermal management. The state-of-the-art and gains to be made by technology advancements will be discussed. Mission requirements for a variety of applications (LEO, GEO, lunar, and Martian) will be treated, and data for power systems ranging from a few kilowatts to megawatt power systems will be represented. In addition the space power technologies being initiated under NASA's new Civilian Space Technology Initiative (CSTI) and Space Leadership Planning Group Activities will be discussed.

Power systems for production, construction, life support, and operations in space

NASA Technical Reports Server (NTRS)

Sovie, Ronald J.

1988-01-01

As one looks to man's future in space it becomes obvious that unprecedented amounts of power are required for the exploration, colonization, and exploitation of space. Activities envisioned include interplanetary travel and LEO to GEO transport using electric propulsion, earth and lunar observatories, advance space stations, free-flying manufacturing platforms, communications platforms, and eventually evolutionary lunar and Mars bases. These latter bases would start as camps with modest power requirements (kWes) and evolve to large bases as manufacturing, food production, and life support materials are developed from lunar raw materials. These latter activities require very robust power supplies (MWes). The advanced power system technologies being pursued by NASA to fulfill these future needs are described. Technologies discussed will include nuclear, photovoltaic, and solar dynamic space power systems, including energy storage, power conditioning, power transmission, and thermal management. The state-of-the-art and gains to be made by technology advancements will be discussed. Mission requirements for a variety of applications (LEO, GEO, lunar, and Martian) will be treated, and data for power systems ranging from a few kilowatts to megawatt power systems will be represented. In addition the space power technologies being initiated under NASA's new Civilian Space Technology Initiative (CSTI) and Space Leadership Planning Group Activities will be discussed.

Hemangiosarcoma in a geriatric Labrador retriever

PubMed Central

Sharma, Diya

2012-01-01

A geriatric Labrador retriever dog was presented for acute collapse. The dog was conscious but lethargic, tachypneic, tachycardic with weak femoral pulses, occasional pulse deficits, and pale mucous membranes. Radiography, ultrasonography, quick assessment tests, and a complete blood (cell) count (CBC)/biochemistry panel indicated internal hemorrhage and potential problems with hemostasis. The dog was euthanized. A necropsy, histopathology, and immunohistochemistry for CD31 and Factor VIII-related antigen cell markers supported a diagnosis of splenic hemangiosarcoma. PMID:23372199

SWAT Model Prediction of Phosphorus Loading in a South Carolina Karst Watershed with a Downstream Embayment

Treesearch

Devendra M. Amatya; Manoj K. Jha; Thomas M. Williams; Amy E. Edwards; Daniel R. Hitchcock

2013-01-01

The SWAT model was used to predict total phosphorus (TP) loadings for a 1555-ha karst watershed—Chapel Branch Creek (CBC)—which drains to a lake via a reservoir-like embayment (R-E). The model was first tested for monthly streamflow predictions from tributaries draining three potential source areas as well as the downstream R-E, followed by TP loadings using data...

Proceedings of Damping 󈨟, Held in San Diego, California on 13 - 15 February 1991. Volume 2

DTIC Science & Technology

1991-08-01

Efficiency CBC* Dr. L. H. Sperling , J. J. Fay, and Dr. D. A. Thomas The Thermorheologically Complex Material CBD* Lt. Col. Ronald L. Bagley SESSION CC...Andrew S. Bicos. and J. S. Fechter The Need for Passive Damping in Feedback Controlled Flexible Struc- GBB tures Dr. Andreas von Flotow and D. W. Vos...Vibration Research, Southampton, England (R.C. Drew) Lehigh University, Bethlehem, Pennsylvania (L. Sperling ) MrS Corporation, Minneapolis, Minnesota

Imaging CXCL12-CXCR4 Signaling and Inhibition in Ovarian Cancer

DTIC Science & Technology

2013-10-01

arrestin 2 and reconstitution of luciferase enzymes to produce light (see attached manuscript from PLoS One). Fig 2. CXCL12-dependent activation...With the luciferase complementa- tion system, interactions between CXCR4 and b-arrestin 2 reconstitute active click beetle luciferase to produce light ...dimensional cell culture experiments We plated 1.56104 HeyA8-CXCR4-CBRN/Ar-CBC cells per well in black wall 96 well plates one day before assays. We

Space Solar Power Program. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arif, Humayun; Barbosa, Hugo; Bardet, Christophe

1992-08-01

Information pertaining to the Space Solar Power Program is presented on energy analysis; markets; overall development plan; organizational plan; environmental and safety issues; power systems; space transportation; space manufacturing, construction, operations; design examples; and finance.

Evaluation of Mindray BC-3600 hematology analyzer in a university hospital.

PubMed

Shu, G; Lu, H; Du, H; Shi, J; Wu, G

2013-02-01

The BC-3600 Auto Hematology Analyzer (hereinafter call BC-3600) is a quantitative, automated hematology analyzer and leukocyte differential counter for In Vitro Diagnostic Use in clinical laboratories. The analyzer was evaluated and compared with the Mindray BC-3200 3-part differential (BC-3200) and Sysmex XE-2100 5-part differential (XE-2100) Hematology Analyzer in the hematology laboratory of a university hospital. The BC-3600 was evaluated according to guidelines published by Clinical and Laboratory Standards Institute (CLSI), the International Committee for Standardization in Hematology (ICSH), and Department of Food and Drug Administration (FDA). There were no background, minimal carryover (<0.5%), and excellent linearity for white blood cell (WBC), hemoglobin (Hb) level, red blood cell (RBC), and platelet (PLT) counts (r > 0.999). Precision was good at all levels for the routine cell blood count (CBC) parameters: CV% being ≤2.0, except for platelet count (PLT) at the low level with CV% of ≤5.0% and WBC at the low level with CV% of <3.0%. Correlation between the BC-3600 and BC-3200, XE-2100 were excellent (r > 0.99) for all major CBC parameters. It is concluded that the overall performance of the BC-3600 is excellent and compares well with that of BC-3200 and XE-2100. © 2012 Blackwell Publishing Ltd.

Evaluation of the Microsemi CRP, an automated hematology analyzer for rapid 3-part WBC differential and CRP using whole blood.

PubMed

Nomura, N; Saito, K; Ikeda, M; Yuasa, S; Pastore, M; Chabert, C; Kono, E; Sakai, A; Tanaka, H; Ikemoto, T; Takubo, T

2015-08-01

We evaluated the basic performance of Microsemi CRP, an unique automated hematology analyzer which can simultaneously measure CBC including 3-part WBC differential (3-Diff) and CRP using whole blood treated with EDTA-2K anticoagulant. We found that it produced generally the acceptable results for all parameters performed (repeatability, reproducibility, linearity, interference effect, carry over, and correlation) using control materials, fresh human whole bloods, and serum samples. CBC data examined using Microsemi CRP showed the good correlation with the previous model, Micros CRP200 (r ≧ 0.9), and also those obtained using the routine analyzer, ADVIA 2120i (r ≧ 0.989). Concerning the 3-Diff, both GRA (%) and LYM (%) showed the excellent correlation coefficient between Microsemi CRP and Micros CRP200 (r ≧ 0.992) as well as ADVIA 2120i (r ≧ 0.957). MON (%) showed good correlation between Microsemi CRP and Micros CRP200 (r = 0.959), but lower correlation between Microsemi CRP and ADVIA 2120 i (r = 0.471). CRP data showed the good correlation with HITACHI7600 (r ≧ 0.997) and Micros CRP200 (r ≧ 0.997). From these findings, we concluded that Microsemi CRP seemed the convenient laboratory analyzer in the setting of point of care testing (POCT) especially at NICU or primary care unit. © 2014 John Wiley & Sons Ltd.

Performance evaluation of the Abbott CELL-DYN Ruby and the Sysmex XT-2000i haematology analysers.

PubMed

Leers, M P G; Goertz, H; Feller, A; Hoffmann, J J M L

2011-02-01

Two mid-range haematology analysers (Abbott CELL-DYN Ruby and Sysmex XT-2000i) were evaluated to determine their analytical performance and workflow efficiency in the haematology laboratory. In total 418 samples were processed for determining equivalence of complete blood count (CBC) measurements, and 100 for reticulocyte comparison. Blood smears served for assessing the agreement of the differential counts. Inter-instrument agreement for most parameters was good although small numbers of discrepancies were observed. Systematic biases were found for mean cell volume, reticulocytes, platelets and mean platelet volume. CELL-DYN Ruby WBC differentials were obtained with all samples while the XT-2000i suppressed differentials partially or completely in 13 samples (3.1%). WBC subpopulation counts were otherwise in good agreement with no major outliers. Following first-pass CBC/differential analysis, 88 (21%) of XT-2000i samples required further analyser processing compared to 18 (4.3%) for the CELL-DYN Ruby. Smear referrals for suspected WBC/nucleated red blood cells and platelet abnormalities were indicated for 106 (25.4%) and 95 (22.7%) of the XT-2000i and CELL-DYN Ruby samples respectively. Flagging efficiencies for both analysers were found to be similar. The Sysmex XT-2000i and Abbott CELL-DYN Ruby analysers have broadly comparable analytical performance, but the CELL-DYN Ruby showed superior first-pass efficiency. © 2010 Blackwell Publishing Ltd.

The effects of different restorative materials on the detection of approximal caries in cone-beam computed tomography scans with and without metal artifact reduction mode.

PubMed

Cebe, Fatma; Aktan, Ali Murat; Ozsevik, Abdul Semih; Ciftci, Mehmet Ertugrul; Surmelioglu, Hatice Derya

2017-03-01

The aim of this study was to investigate the influence of artifacts produced by different restorative materials on the detection of approximal caries in cone-beam computed tomography (CBCT) scans with and without the application of an artifact-reduction (AR) option. Ninety-eight noncavitated premolar and molar teeth were placed with approximal contacts consisting of 2 sound or carious teeth and 1 mesial-occlusal-distal restored tooth with resin-modified glass-ionomer cement (RMGIC), amalgam, composite, ceramic-based composite (CBC), or computer-aided design-computer-aided manufacturing (CAD-CAM) zirconia materials in between. The teeth were scanned with a CBCT system with and without the AR option. Images were evaluated by 2 observers. The teeth were histologically evaluated, and sensitivity, specificity, and areas under the receiver operating characteristic (ROC) curve were calculated according to the appropriate threshold. Specificity and sensitivity values for contact surfaces ranged from 0-48.39 and 82.93-98.40, respectively. The AR option affected (P < .05) approximal caries detection of the amalgam, composite, CAD-CAM, and CBC groups in contact surfaces and composite and RMGIC groups in noncontact surfaces. Artifacts produced by different restorative materials could affect approximal caries detection in CBCT scans. Use of the AR option with CBCT scans increases the accuracy of approximal caries detection. Copyright © 2016 Elsevier Inc. All rights reserved.

Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom.

PubMed

Lisboa, Antonio; Melaré, Rodolfo; Franco, Junia R B; Bis, Carolina V; Gracia, Marta; Ponce-Soto, Luis A; Marangoni, Sérgio; Rodrigues-Simioni, Léa; da Cruz-Höfling, Maria Alice; Rocha, Thalita

2016-01-01

Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B. marajoensis venom. CBC incubated with toxins showed irreversible twitch tension blockade and unaffected KCl- and ACh-evoked contractures, and the positive colabelling of acetylcholine receptors confirmed that their action was primarily at the motor nerve terminal. Hypercontraction and loose myofilaments and synaptic vesicle depletion and motor nerve damage indicated that the toxins displayed both myotoxic and neurotoxic effect. The blockade resulted from interference on synaptophysin, synaptobrevin, and SNAP25 proteins leading to the conclusion that BmjeTX-I and BmjeTX-II affected neurotransmitter release machinery by preventing the docking of synaptic vesicles to the axolemma of the nerve terminal.

Electrical system options for space exploration

NASA Technical Reports Server (NTRS)

Bercaw, Robert W.; Cull, Ronald C.

1991-01-01

The need for a space power utility concept is discussed and the impact of this concept on the engineering of space power systems is examined. Experiences gained from Space Station Freedom and SEI systems studies are used to discuss the factors that may affect the choice of frequency standards on which to build such a space power utility. Emphasis is given to electrical power control, conditioning, and distribution subsystems.

Spacecraft Power Systems Engineering: Solutions for NASA's Manned Space Program

NASA Technical Reports Server (NTRS)

Scott, John H.

2007-01-01

An overview of spacecraft power systems is presented, with a focus on applications in the manned space program. The topics include: 1) History; 2) State-of-the-art; 3) Development directions; 4) Focus on applications in the manned space program led from JSC; 5) Power Systems Engineering Trade Space; 6) Power Generation and Energy Storage; 7) Power Distribution and Control; and 8) Actuation

Issues and status of power distribution options for space exploration

NASA Technical Reports Server (NTRS)

Bercaw, Robert W.; Cull, Ronald C.; Kenny, Barbara H.

1991-01-01

The Space Exploration Initiative (SEI) will need a wide variety of manned systems with requirements significantly different than those for existing systems. The concept of a space power utility is discussed and the impact of this concept on the engineering of space power systems is examined. Almost all existing space power systems use low voltage direct current. Although they have been very succesful, increasing power system requirements in recent years have exposed their inherent limitations and led to the proposal of a number of alternatives including high voltage DC and AC at various frequencies. Drawing on the experience gained from Space Station Freedom and SEI systems studies, factors that may affect the choice of frequency standards on which to build such a space power utility are discussed.

Advanced Energy Conversion Technologies and Architectures for Earth and Beyond

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Fikes, John C.; Phillips, Dane J.; Laycock, Rustin L.; ONeill, Mark; Henley, Mark W.; Fork, Richard L.

2006-01-01

Research, development and studies of novel space-based solar power systems, technologies and architectures for Earth and beyond are needed to reduce the cost of clean electrical power for terrestrial use and to provide a stepping stone for providing an abundance of power in space, i.e., manufacturing facilities, tourist facilities, delivery of power between objects in space, and between space and surface sites. The architectures, technologies and systems needed for space to Earth applications may also be used for in-space applications. Advances in key technologies, i.e., power generation, power management and distribution, power beaming and conversion of beamed power are needed to achieve the objectives of both terrestrial and extraterrestrial applications. There is a need to produce "proof-ofconcept" validation of critical WPT technologies for both the near-term, as well as far-term applications. Investments may be harvested in near-term beam safe demonstrations of commercial WPT applications. Receiving sites (users) include ground-based stations for terrestrial electrical power, orbital sites to provide power for satellites and other platforms, future space elevator systems, space vehicle propulsion, and space surface sites. Space surface receiving sites of particular interest include the areas of permanent shadow near the moon s North and South poles, where WPT technologies could enable access to ice and other useful resources for human exploration. This paper discusses work addressing a promising approach to solar power generation and beamed power conversion. The approach is based on a unique high-power solar concentrator array called Stretched Lens Array (SLA) applied to both solar power generation and beamed power conversion. Since both versions (solar and laser) of SLA use many identical components (only the photovoltaic cells need to be different), economies of manufacturing and scale may be realized by using SLA on both ends of the laser power beaming system in a space solar power application. Near-term uses of this SLA-laser-SLA system may include terrestrial and space exploration in near Earth space. Later uses may include beamed power for bases or vehicles on Mars. Strategies for developing energy infrastructures in space which utilize this technology are presented. This dual use system produces electrical energy efficiently from either coherent light, such as from a highly coherent laser, or from conventional solar illumination. This allows, for example, supplementing solar energy with energy provided by highly coherent laser illumination during periods of low solar illumination or no illumination. This reduces the need for batteries and alternate sources of power. The capability of using laser illumination in a lowest order Gaussian laser mode provides means for transmitting power optically with maximum efficiency and precision over the long distances characteristic of space. A preliminary receiving system similar to that described here, has been produced and tested under solar and laser illumination. A summary of results is given.

Recent Advances in Nuclear Powered Electric Propulsion for Space Exploration

NASA Technical Reports Server (NTRS)

Cassady, R. Joseph; Frisbee, Robert H.; Gilland, James H.; Houts, Michael G.; LaPointe, Michael R.; Maresse-Reading, Colleen M.; Oleson, Steven R.; Polk, James E.; Russell, Derrek; Sengupta, Anita

2007-01-01

Nuclear and radioisotope powered electric thrusters are being developed as primary in-space propulsion systems for potential future robotic and piloted space missions. Possible applications for high power nuclear electric propulsion include orbit raising and maneuvering of large space platforms, lunar and Mars cargo transport, asteroid rendezvous and sample return, and robotic and piloted planetary missions, while lower power radioisotope electric propulsion could significantly enhance or enable some future robotic deep space science missions. This paper provides an overview of recent U.S. high power electric thruster research programs, describing the operating principles, challenges, and status of each technology. Mission analysis is presented that compares the benefits and performance of each thruster type for high priority NASA missions. The status of space nuclear power systems for high power electric propulsion is presented. The paper concludes with a discussion of power and thruster development strategies for future radioisotope electric propulsion systems,

Brayton Cycle Power System in the Space Power Facility

NASA Image and Video Library

1969-07-21

Set up of a Brayton Cycle Power System test in the Space Power Facility’s massive vacuum chamber at the National Aeronautics and Space Administration’s (NASA) Plum Brook Station in Sandusky, Ohio. The $28.4-million facility, which began operations in 1969, is the largest high vacuum chamber ever built. The chamber is 100 feet in diameter and 120 feet high. It can produce a vacuum deep enough to simulate the conditions at 300 miles altitude. The Space Power Facility was originally designed to test nuclear-power sources for spacecraft, but it was never used for that purpose. The Space Power Facility was first used to test a 15 to 20-kilowatt Brayton Cycle Power System for space applications. Three different methods of simulating solar heat were employed during the tests. Lewis researchers studied the Brayton power system extensively in the 1960s and 1970s. The Brayton engine converted solar thermal energy into electrical power. The system operated on a closed-loop Brayton thermodynamic cycle with a helium-xenon gas mixture as its working fluid. A space radiator was designed to serve as the system’s waste heat rejecter. The radiator was later installed in the vacuum chamber and tested in a simulated space environment to determine its effect on the power conversion system. The Brayton system was subjected to simulated orbits with 62 minutes of sun and 34 minutes of shade.

Modern Air&Space Power and political goals at war

NASA Astrophysics Data System (ADS)

Özer, Güngör.

2014-05-01

Modern AirandSpace Power is increasingly becoming a political tool. In this article, AirandSpacePower as a political tool will be discussed. The primary purpose of this article is to search how AirandSpacePower can provide contributions to security and also determine if it may reach the political goals on its own at war by SWOT Analysis Method and analysing the role of AirandSpace Power in Operation Unified Protector (Libya) as a case study. In conclusion, AirandSpacePower may not be sufficient to win the political goals on its own. However it may reach the political aims partially against the adversary on its own depending upon the situations. Moreover it can alone persuade the adversary to alter its behavior(s) in war.

Advanced power sources for space missions

NASA Technical Reports Server (NTRS)

Gavin, Joseph G., Jr.; Burkes, Tommy R.; English, Robert E.; Grant, Nicholas J.; Kulcinski, Gerald L.; Mullin, Jerome P.; Peddicord, K. Lee; Purvis, Carolyn K.; Sarjeant, W. James; Vandevender, J. Pace

1989-01-01

Approaches to satisfying the power requirements of space-based Strategic Defense Initiative (SDI) missions are studied. The power requirements for non-SDI military space missions and for civil space missions of the National Aeronautics and Space Administration (NASA) are also considered. The more demanding SDI power requirements appear to encompass many, if not all, of the power requirements for those missions. Study results indicate that practical fulfillment of SDI requirements will necessitate substantial advances in the state of the art of power technology. SDI goals include the capability to operate space-based beam weapons, sometimes referred to as directed-energy weapons. Such weapons pose unprecedented power requirements, both during preparation for battle and during battle conditions. The power regimes for these two sets of applications are referred to as alert mode and burst mode, respectively. Alert-mode power requirements are presently stated to range from about 100 kW to a few megawatts for cumulative durations of about a year or more. Burst-mode power requirements are roughly estimated to range from tens to hundreds of megawatts for durations of a few hundred to a few thousand seconds. There are two likely energy sources, chemical and nuclear, for powering SDI directed-energy weapons during the alert and burst modes. The choice between chemical and nuclear space power systems depends in large part on the total duration during which power must be provided. Complete study findings, conclusions, and eight recommendations are reported.

Parameter Estimation for Compact Binaries with Ground-Based Gravitational-Wave Observations Using the LALInference

NASA Technical Reports Server (NTRS)

Veitch, J.; Raymond, V.; Farr, B.; Farr, W.; Graff, P.; Vitale, S.; Aylott, B.; Blackburn, K.; Christensen, N.; Coughlin, M.

2015-01-01

The Advanced LIGO and Advanced Virgo gravitational wave (GW) detectors will begin operation in the coming years, with compact binary coalescence events a likely source for the first detections. The gravitational waveforms emitted directly encode information about the sources, including the masses and spins of the compact objects. Recovering the physical parameters of the sources from the GW observations is a key analysis task. This work describes the LALInference software library for Bayesian parameter estimation of compact binary signals, which builds on several previous methods to provide a well-tested toolkit which has already been used for several studies. We show that our implementation is able to correctly recover the parameters of compact binary signals from simulated data from the advanced GW detectors. We demonstrate this with a detailed comparison on three compact binary systems: a binary neutron star (BNS), a neutron star - black hole binary (NSBH) and a binary black hole (BBH), where we show a cross-comparison of results obtained using three independent sampling algorithms. These systems were analysed with non-spinning, aligned spin and generic spin configurations respectively, showing that consistent results can be obtained even with the full 15-dimensional parameter space of the generic spin configurations. We also demonstrate statistically that the Bayesian credible intervals we recover correspond to frequentist confidence intervals under correct prior assumptions by analysing a set of 100 signals drawn from the prior. We discuss the computational cost of these algorithms, and describe the general and problem-specific sampling techniques we have used to improve the efficiency of sampling the compact binary coalescence (CBC) parameter space.

Symposium on Space Industrialization, Huntsville, Ala., May 26, 27, 1976, Proceedings

NASA Technical Reports Server (NTRS)

1976-01-01

Space habitats are considered, with attention given the evolution of space station systems, space station habitability, space settlement planning methodology, and orbital assembly. Various aspects of the Space Transportation System are discussed, including Shuttle booster/propulsion growth concept, advanced earth orbital transportation systems technology, single-stage-to-orbit vehicles and aeromaneuvering orbit transfer vehicles. Materials processing in space is examined, with emphasis on biological materials, metallurgical materials, the uses of space ultrahigh vacuum, and extraterrestrial mining and industrial processing. Solar space power is investigated, with attention given the potential of satellite solar power stations, thermal engine power satellites and microwave power transmission to earth. Individual items are announced in this issue.

Overview of free-piston Stirling engine technology for space power application

NASA Technical Reports Server (NTRS)

Slaby, Jack G.

1987-01-01

An overview is presented of free-piston Stirling engine activities, directed toward space power applications. One of the major elements of the program is the development of advanced power conversion. Under this program the status of the 25 kWe opposed-piston Space Power Demonstrator Engine (SPDE) is presented. Initial differences between predicted and experimental power outputs and power output influenced by variations in regenerators are discussed. Technology work was conducted on heat-exchanger concepts to minimize the number of joints as well as to enhance the heat transfer in the heater. Design parameters and conceptual design features are also presented for a 25 kWe, single-cylinder free-piston Stirling space power converter. Projections are made for future space power requirements over the next few decades along with a recommendation to consider the use of dynamic power conversion systems, either solar or nuclear. A cursory comparison is presented showing the mass benefits of a Stirling system over a Brayton system for the same peak temperature and output power. A description of a study to investigate the feasibility of scaling a single-cylinder free-piston Stirling space power module to the 150 kWe power range is presented.

Comparison of ZigBee Replay Attacks Using a Universal Software Radio Peripheral and USB Radio

DTIC Science & Technology

2014-03-27

authentication code (CBC-MAC) CPU central processing unit CUT component under test db decibel dbm decibel referenced to one milliwatt FFD full- fuction ...categorized into two different types: full- fuction devices (FFDs) and reduced-function devices (RFDs). The difference between an FFD and an RFD is that...KillerBee Hardware. Although KillerBee can be used with any hardware that can interact with 802.15.4 networks, the primary development hardware is the

Waste-Oil Boiler Firing Demonstration at Naval Weapon Center China Lake, California.

DTIC Science & Technology

1980-06-01

Div. (F. Hein). Madrid . Spain NAVHOSP PWO, Beaufort SC NAVMAG SCE. Guam NAVMEDRSCHU 3 PWO. Cairo U.A.R NAVOCEANSYSCEN Code 41. San Diego . CA: Code...John Dollman, Wayne Jackson, and Larry Mosby . The Navy Environmental Support Office of CBC, Port Hueneme, provided and installed instrumentation for...MCRD PWO. San Diego Ca 24 FTI9 SCE San Diego , CA NAF PWD - Engr Div, Atsugi, Japan; PWO Sigonella Sicily: PWO. Atsugi Japan: PWO. Mount Clemens MI NALF

Depressurization amorphization of single-crystal boron carbide.

PubMed

Yan, X Q; Tang, Z; Zhang, L; Guo, J J; Jin, C Q; Zhang, Y; Goto, T; McCauley, J W; Chen, M W

2009-02-20

We report depressurization amorphization of single-crystal boron carbide (B4C) investigated by in situ high-pressure Raman spectroscopy. It was found that localized amorphization of B4C takes place during unloading from high pressures, and nonhydrostatic stresses play a critical role in the high-pressure phase transition. First-principles molecular dynamics simulations reveal that the depressurization amorphization results from pressure-induced irreversible bending of C-B-C atomic chains cross-linking 12 atom icosahedra at the rhombohedral vertices.

The Physics and Chemistry of carbides, Nitrides and Borides. Volume 185

DTIC Science & Technology

1990-01-01

and C-B-C chains [15,17]. Clearly, the use of boron-rich solids as electronic materials will place new demands on the quality of materials. In this...first heated in a pyrolytic boron nitride (PBN) crucible ( Union Carbide Corp.) under high vacuum (< 50 mTorr) to 1900°C. This removed surface...contamination of the sample. The powders were loaded into a graphite die with a high-purity BN die liner ( Union Carbide Grade HBC) with inner diameter of 3/8

An Analysis of the Effects of Phenytoin in Treating Motion Sickness and the Effects of Motion Sickness on the Human Electroencephalogram

DTIC Science & Technology

1990-12-01

ears ( tinnitus ) and/or a reduced auditory acuity resulted from the dosing. These side effects have been shown to 29 occur in some subjects as a result of...examinations. 5. Complete blood count (CBC). 6. Blood biochemistry screen (Chem 18 including liver function tests). 7. Blood cholesterol and lipids . 8. Chest X...blood lipids and cholesterol, chest X-ray, urinalysis, visual acuity test, vestibular evaluation and liver function studies. Subjects will then take

Cobalt-Free Permanent Magnet Alloys.

DTIC Science & Technology

1984-10-01

carbide co- UC CbC lumbium carbide M003 Uranium carbide - tho- UC 2 25ThC rium carbide ZrO2 MgO WOs Use of this Process for MnAlC As indicated in the...cobalt. Free World Cobal Consumption Estimated Breakdown by End Uses Magnetic alloys 20% Cemented carbides - 5% 30 SuPerolloy _ 15% Other steels and...would normally result in the formation of binary alloy of TbFe 2 and preventing the formation of amorphous alloy (Fe-B) contain- ing Tb. The

Nuclear space power safety and facility guidelines study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehlman, W.F.

1995-09-11

This report addresses safety guidelines for space nuclear reactor power missions and was prepared by The Johns Hopkins University Applied Physics Laboratory (JHU/APL) under a Department of Energy grant, DE-FG01-94NE32180 dated 27 September 1994. This grant was based on a proposal submitted by the JHU/APL in response to an {open_quotes}Invitation for Proposals Designed to Support Federal Agencies and Commercial Interests in Meeting Special Power and Propulsion Needs for Future Space Missions{close_quotes}. The United States has not launched a nuclear reactor since SNAP 10A in April 1965 although many Radioisotope Thermoelectric Generators (RTGs) have been launched. An RTG powered system ismore » planned for launch as part of the Cassini mission to Saturn in 1997. Recently the Ballistic Missile Defense Office (BMDO) sponsored the Nuclear Electric Propulsion Space Test Program (NEPSTP) which was to demonstrate and evaluate the Russian-built TOPAZ II nuclear reactor as a power source in space. As of late 1993 the flight portion of this program was canceled but work to investigate the attributes of the reactor were continued but at a reduced level. While the future of space nuclear power systems is uncertain there are potential space missions which would require space nuclear power systems. The differences between space nuclear power systems and RTG devices are sufficient that safety and facility requirements warrant a review in the context of the unique features of a space nuclear reactor power system.« less

Space vehicle electrical power processing distribution and control study. Volume 1: Summary

NASA Technical Reports Server (NTRS)

Krausz, A.

1972-01-01

A concept for the processing, distribution, and control of electric power for manned space vehicles and future aircraft is presented. Emphasis is placed on the requirements of the space station and space shuttle configurations. The systems involved are referred to as the processing distribution and control system (PDCS), electrical power system (EPS), and electric power generation system (EPGS).

Distributed Space Solar Power

NASA Technical Reports Server (NTRS)

Fork, Richard L.

2001-01-01

The objective was to assess the feasibility of safely collecting solar power at geostationary orbit and delivering it to earth. A strategy which could harness a small fraction of the millions of gigawatts of sunlight passing near earth could adequately supply the power needs of earth and those of space exploration far into the future. Light collected and enhanced both spatially and temporally in space and beamed to earth provides probably the only practical means of safe and efficient delivery of this space solar power to earth. In particular, we analyzed the feasibility of delivering power to sites on earth at a comparable intensity, after conversion to a usable form, to existing power needs. Two major obstacles in the delivery of space solar power to earth are safety and the development of a source suitable for space. We focused our approach on: (1) identifying system requirements and designing a strategy satisfying current eye and skin safety requirements; and (2) identifying a concept for a potential space-based source for producing the enhanced light.

A Historical Review of Brayton and Stirling Power Conversion Technologies for Space Applications

NASA Technical Reports Server (NTRS)

Mason, Lee S.; Schreiber, Jeffrey G.

2007-01-01

Dynamic power conversion technologies, such as closed Brayton and free-piston Stirling, offer many advantages for space power applications including high efficiency, long life, and attractive scaling characteristics. This paper presents a historical review of Brayton and Stirling power conversion technology for space and discusses on-going development activities in order to illustrate current technology readiness. The paper also presents a forecast of potential future space uses of these power technologies.

Scientific and technical complex for modeling, researching and testing of rocket-space vehicles’ electric power installations

NASA Astrophysics Data System (ADS)

Bezruchko, Konstantin; Davidov, Albert

2009-01-01

In the given article scientific and technical complex for modeling, researching and testing of rocket-space vehicles' power installations which was created in Power Source Laboratory of National Aerospace University "KhAI" is described. This scientific and technical complex gives the opportunity to replace the full-sized tests on model tests and to reduce financial and temporary inputs at modeling, researching and testing of rocket-space vehicles' power installations. Using the given complex it is possible to solve the problems of designing and researching of rocket-space vehicles' power installations efficiently, and also to provide experimental researches of physical processes and tests of solar and chemical batteries of rocket-space complexes and space vehicles. Scientific and technical complex also allows providing accelerated tests, diagnostics, life-time control and restoring of chemical accumulators for rocket-space vehicles' power supply systems.

RHETT and SCARLET: Synergistic power and propulsion technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, D.M.; Curran, F.M.; Sankovic, J.

1995-12-31

The Ballistic Missile Defense Organization (BMDO) sponsors an aggressive program to qualify high performance space power and electric propulsion technologies for space flight. Specifically, the BMDO space propulsion program is now integrating an advanced Hall thruster system including all components necessary for use in an operational spacecraft. This Russian Hall Effect Thruster Technology (RHETT) integrated pallet will be qualified for space flight later this year. This will be followed by a space flight demonstration and verification in 1996. The BMDO power program includes a parallel program to qualify and space flight demonstrate the Solar Concentrator Arrays with Refractive Linear Elementmore » Technology (SCARLET). The first flight SCARLET system is being fabricated for Use on the EER/CTA Comet spacecraft in late July. The space flight demonstration is the first full size, deployed concentrator solar array. The propulsion work is conducted by an industry team led by Space Power, Inc. and Olin Aerospace with their partners in Russia, NIITP and TsNIIMash. The power program is conducted by an industry team led by AEC-Able. This paper is to familiarize the space power community with the synergies between spacecraft power and electric propulsion.« less

The economic viability of pursuing a space power system concept

NASA Technical Reports Server (NTRS)

Hazelrigg, G. A., Jr.

1977-01-01

The development of a space power system requires no fundamental technological breakthroughs. There are, however, uncertainties regarding the degree to which necessary developments can be achieved or exceeded. An analysis is conducted concerning the implementation of a 5000 MW space-based solar power system based on photovoltaic conversion of solar energy to electrical energy. The solar array is about 13 km long and 5 km wide. Placed in geosynchronous orbit, it provides power to the earth for 30 years. Attention is given to the economic feasibility of a space power system, a risk analysis for space power systems, and the use of the presented methodology for comparing alternative technology development programs.

Progress in space power technology

NASA Technical Reports Server (NTRS)

Mullin, J. P.; Randolph, L. P.; Hudson, W. R.

1980-01-01

The National Aeronautics and Space Administration's Space Power Research and Technology Program has the objective of providing the technology base for future space power systems. The current technology program which consists of photovoltaic energy conversion, chemical energy conversion and storage, thermal-to-electric conversion, power systems management and distribution, and advanced energetics is discussed. In each area highlights, current programs, and near-term directions will be presented.

Challenges for future space power systems

NASA Technical Reports Server (NTRS)

Brandhorst, Henry W., Jr.

1989-01-01

Forecasts of space power needs are presented. The needs fall into three broad categories: survival, self-sufficiency, and industrialization. The cost of delivering payloads to orbital locations and from Low Earth Orbit (LEO) to Mars are determined. Future launch cost reductions are predicted. From these projections the performances necessary for future solar and nuclear space power options are identified. The availability of plentiful cost effective electric power and of low cost access to space are identified as crucial factors in the future extension of human presence in space.

Exercise of the SSM/PMAD Breadboard. [Space Station Module/Power Management And Distribution

NASA Technical Reports Server (NTRS)

Walls, Bryan

1989-01-01

The Space Station Module Power Management and Distribution (SSM/PMAD) Breadboard is a test facility designed for advanced development of space power automation. Originally designed for 20-kHz power, the system is being converted to work with direct current (dc). Power levels are on a par with those expected for a Space Station module. Some of the strengths and weaknesses of the SSM/PMAD system in design and function are examined, and the future directions foreseen for the system are outlined.

Space Station Freedom power - A reliability, availability, and maintainability assessment of the proposed Space Station Freedom electric power system

NASA Technical Reports Server (NTRS)

Turnquist, S. R.; Twombly, M.; Hoffman, D.

1989-01-01

A preliminary reliability, availability, and maintainability (RAM) analysis of the proposed Space Station Freedom electric power system (EPS) was performed using the unit reliability, availability, and maintainability (UNIRAM) analysis methodology. Orbital replacement units (ORUs) having the most significant impact on EPS availability measures were identified. Also, the sensitivity of the EPS to variations in ORU RAM data was evaluated for each ORU. Estimates were made of average EPS power output levels and availability of power to the core area of the space station. The results of assessments of the availability of EPS power and power to load distribution points in the space stations are given. Some highlights of continuing studies being performed to understand EPS availability considerations are presented.

Development status of the heatpipe power and bimodal systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poston, David I.; Houts, Michael G.

1999-01-01

Space fission power systems can potentially enhance or enable ambitious lunar and Martian surface missions. Research into space fission power systems has been ongoing (at various levels) since the 1950s, but to date the United States (US) has flown only one space fission system, SNAP-10A, in 1965. Cost and development time have been significant reasons why space fission systems have not been used by the US. High cost and long development time are not inherent to the use of space fission power. However, high cost and long development time are inherent to any program that tries to do too muchmore » at once. Nearly all US space fission power programs have attempted to field systems capable of high power, even though more modest systems had not yet been flown. All of these programs have failed to fly a space fission system. Relatively low power (10 to 100 kWe) fission systems may be useful for near-term lunar and Martian surface missions, including missions in which in situ resource utilization is a priority. Such systems may also be useful for deep-space science missions and other missions. These systems can be significantly less expensive to develop than high power systems. Experience gained in the development of low-power space fission systems can then be used to enable cost-effective development of high-power ({gt}1000 kWe) fission systems. The Heatpipe Power System (HPS) is a potential, near-term, low-cost space fission power system. The Heatpipe Bimodal System (HBS) is a potential, near-term, low-cost space fission power and/or propulsion system. Both systems will be composed of independent modules, and all components use existing technology and operate within the existing database. The HPS and HBS have relatively few system integration issues; thus, the successful development of a module is a significant step toward verifying system feasibility and performance estimates. A prototypic HPS module was fabricated, and initial testing was completed in April 1997. All test objectives were accomplished, demonstrating the basic feasibility of the HPS. Fabrication of an HBS module is under way, and testing should begin in 1999. {copyright} {ital 1999 American Institute of Physics.}« less

Development status of the heatpipe power and bimodal systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poston, David I.; Houts, Michael G.; Emrich, William J. Jr.

1999-01-22

Space fission power systems can potentially enhance or enable ambitious lunar and Martian surface missions. Research into space fission power systems has been ongoing (at various levels) since the 1950s, but to date the United States (US) has flown only one space fission system, SNAP-10A, in 1965. Cost and development time have been significant reasons why space fission systems have not been used by the US. High cost and long development time are not inherent to the use of space fission power. However, high cost and long development time are inherent to any program that tries to do too muchmore » at once. Nearly all US space fission power programs have attempted to field systems capable of high power, even though more modest systems had not yet been flown. All of these programs have failed to fly a space fission system. Relatively low power (10 to 100 kWe) fission systems may be useful for near-term lunar and Martian surface missions, including missions in which in situ resource utilization is a priority. Such systems may also be useful for deep-space science missions and other missions. These systems can be significantly less expensive to develop than high power systems. Experience gained in the development of low-power space fission systems can then be used to enable cost-effective development of high-power (>1000 kWe) fission systems. The Heatpipe Power System (HPS) is a potential, near-term, low-cost space fission power system. The Heatpipe Bimodal System (HBS) is a potential, near-term, low-cost space fission power and/or propulsion system. Both systems will be composed of independent modules, and all components use existing technology and operate within the existing database. The HPS and HBS have relatively few system integration issues; thus, the successful development of a module is a significant step toward verifying system feasibility and performance estimates. A prototypic HPS module was fabricated, and initial testing was completed in April 1997. All test objectives were accomplished, demonstrating the basic feasibility of the HPS. Fabrication of an HBS module is under way, and testing should begin in 1999.« less

Development status of the heatpipe power and bimodal systems

NASA Astrophysics Data System (ADS)

Poston, David I.; Houts, Michael G.; Emrich, William J.

1999-01-01

Space fission power systems can potentially enhance or enable ambitious lunar and Martian surface missions. Research into space fission power systems has been ongoing (at various levels) since the 1950s, but to date the United States (US) has flown only one space fission system, SNAP-10A, in 1965. Cost and development time have been significant reasons why space fission systems have not been used by the US. High cost and long development time are not inherent to the use of space fission power. However, high cost and long development time are inherent to any program that tries to do too much at once. Nearly all US space fission power programs have attempted to field systems capable of high power, even though more modest systems had not yet been flown. All of these programs have failed to fly a space fission system. Relatively low power (10 to 100 kWe) fission systems may be useful for near-term lunar and Martian surface missions, including missions in which in situ resource utilization is a priority. Such systems may also be useful for deep-space science missions and other missions. These systems can be significantly less expensive to develop than high power systems. Experience gained in the development of low-power space fission systems can then be used to enable cost-effective development of high-power (>1000 kWe) fission systems. The Heatpipe Power System (HPS) is a potential, near-term, low-cost space fission power system. The Heatpipe Bimodal System (HBS) is a potential, near-term, low-cost space fission power and/or propulsion system. Both systems will be composed of independent modules, and all components use existing technology and operate within the existing database. The HPS and HBS have relatively few system integration issues; thus, the successful development of a module is a significant step toward verifying system feasibility and performance estimates. A prototypic HPS module was fabricated, and initial testing was completed in April 1997. All test objectives were accomplished, demonstrating the basic feasibility of the HPS. Fabrication of an HBS module is under way, and testing should begin in 1999.

Space power systems technology enablement study. [for the space transportation system

NASA Technical Reports Server (NTRS)

Smith, L. D.; Stearns, J. W.

1978-01-01

The power system technologies which enable or enhance future space missions requiring a few kilowatts or less and using the space shuttle were assessed. The advances in space power systems necessary for supporting the capabilities of the space transportation system were systematically determined and benefit/cost/risk analyses were used to identify high payoff technologies and technological priorities. The missions that are enhanced by each development are discussed.

Free-Space Power Transmission

NASA Technical Reports Server (NTRS)

1989-01-01

NASA Lewis Research Center organized a workshop on technology availability for free-space power transmission (beam power). This document contains a collection of viewgraph presentations that describes the effort by academia, industry, and the national laboratories in the area of high-frequency, high-power technology applicable to free-space power transmission systems. The areas covered were rectenna technology, high-frequency, high-power generation (gyrotrons, solar pumped lasers, and free electron lasers), and antenna technology.

Introduction of a Current Waveform, Waveshaping Technique to Limit Conduction Loss in High-Frequency DC-DC Converters Suitable for Space Power

DTIC Science & Technology

1990-06-01

resonant Buck converter 19 ABSTRACT (Continue on reverse if necessary and identify by block number) Space power supply manufacturers have tried to...increase power density and construct smaller, highly efficient power supplies by increasing switching frequency. Incorporation of a power MOSFET as a...Michael, Second Reader \\’-. ohn P. Powers , Chairman Department of Electrical Engineering iii ABSTRACT Space power supply manufacturers have tried to

The US space station and its electric power system

NASA Technical Reports Server (NTRS)

Thomas, Ronald L.

1988-01-01

The United States has embarked on a major development program to have a space station operating in low earth orbit by the mid-1990s. This endeavor draws on the talents of NASA and most of the aerospace firms in the U.S. Plans are being pursued to include the participation of Canada, Japan, and the European Space Agency in the space station. From the start of the program these was a focus on the utilization of the space station for science, technology, and commercial endeavors. These requirements were utilized in the design of the station and manifest themselves in: pressurized volume; crew time; power availability and level of power; external payload accommodations; microgravity levels; servicing facilities; and the ability to grow and evolve the space station to meet future needs. President Reagan directed NASA to develop a permanently manned space station in his 1984 State of the Union message. Since then the definition phase was completed and the development phase initiated. A major subsystem of the space station is its 75 kW electric power system. The electric power system has characteristics similar to those of terrestrial power systems. Routine maintenance and replacement of failed equipment must be accomplished safely and easily and in a minimum time while providing reliable power to users. Because of the very high value placed on crew time it is essential that the power system operate in an autonomous mode to minimize crew time required. The power system design must also easily accommodate growth as the power demands by users are expected to grow. An overview of the U.S. space station is provided with special emphasis on its electrical power system.

Asymmetrical booster ascent guidance and control system design study. Volume 5: Space shuttle powered explicit guidance. [space shuttle development

NASA Technical Reports Server (NTRS)

Jaggers, R. F.

1974-01-01

An optimum powered explicit guidance algorithm capable of handling all space shuttle exoatospheric maneuvers is presented. The theoretical and practical basis for the currently baselined space shuttle powered flight guidance equations and logic is documented. Detailed flow diagrams for implementing the steering computations for all shuttle phases, including powered return to launch site (RTLS) abort, are also presented. Derivation of the powered RTLS algorithm is provided, as well as detailed flow diagrams for implementing the option. The flow diagrams and equations are compatible with the current powered flight documentation.

Nuclear Power in Space

DOE R&D Accomplishments Database

1994-01-01

In the early years of the United States space program, lightweight batteries, fuel cells, and solar modules provided electric power for space missions. As missions became more ambitious and complex, power needs increased and scientists investigated various options to meet these challenging power requirements. One of the options was nuclear energy. By the mid-1950s, research had begun in earnest on ways to use nuclear power in space. These efforts resulted in the first radioisotope thermoelectric generators (RTGs), which are nuclear power generators build specifically for space and special terrestrial uses. These RTGs convert the heat generated from the natural decay of their radioactive fuel into electricity. RTGs have powered many spacecraft used for exploring the outer planets of the solar system and orbiting the sun and Earth. They have also landed on Mars and the moon. They provide the power that enables us to see and learn about even the farthermost objects in our solar system.

46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Remote Stopping Systems § 111.103-1 Power ventilation systems except machinery space ventilation systems. Each power ventilation system must... 46 Shipping 4 2010-10-01 2010-10-01 false Power ventilation systems except machinery space...

46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Remote Stopping Systems § 111.103-1 Power ventilation systems except machinery space ventilation systems. Each power ventilation system must... 46 Shipping 4 2011-10-01 2011-10-01 false Power ventilation systems except machinery space...

46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Remote Stopping Systems § 111.103-1 Power ventilation systems except machinery space ventilation systems. Each power ventilation system must... 46 Shipping 4 2014-10-01 2014-10-01 false Power ventilation systems except machinery space...

46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Remote Stopping Systems § 111.103-1 Power ventilation systems except machinery space ventilation systems. Each power ventilation system must... 46 Shipping 4 2012-10-01 2012-10-01 false Power ventilation systems except machinery space...

46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Remote Stopping Systems § 111.103-1 Power ventilation systems except machinery space ventilation systems. Each power ventilation system must... 46 Shipping 4 2013-10-01 2013-10-01 false Power ventilation systems except machinery space...

Artificial intelligence and space power systems automation

NASA Technical Reports Server (NTRS)

Weeks, David J.

1987-01-01

Various applications of artificial intelligence to space electrical power systems are discussed. An overview is given of completed, on-going, and planned knowledge-based system activities. These applications include the Nickel-Cadmium Battery Expert System (NICBES) (the expert system interfaced with the Hubble Space Telescope electrical power system test bed); the early work with the Space Station Experiment Scheduler (SSES); the three expert systems under development in the space station advanced development effort in the core module power management and distribution system test bed; planned cooperation of expert systems in the Core Module Power Management and Distribution (CM/PMAD) system breadboard with expert systems for the space station at other research centers; and the intelligent data reduction expert system under development.

SP-100 nuclear space power systems with application to space commercialization

NASA Technical Reports Server (NTRS)

Smith, John M.

1988-01-01

The purpose of this paper is to familiarize the Space Commercialization Community with the status and characteristics of the SP-100 space nuclear power system. The program is a joint undertaking by the Department of Defense, the Department of Energy and NASA. The goal of the program is to develop, validate, and demonstrate the technology for space nuclear power systems in the range of 10 to 1000 kWe electric for use in the future civilian and military space missions. Also discussed are mission applications which are enhanced and/or enabled by SP-100 technology and how this technology compares to that of more familiar solar power systems. The mission applications include earth orbiting platforms and lunar/Mars surface power.

Space transportation alternatives for large space programs: The International Space University Summer Session, 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

1993-01-01

In 1992, the International Space University (ISU) held its Summer Session in Kitakyushu, Japan. This paper summarizes and expands upon some aspects of space solar power and space transportation that were considered during that session. The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW, or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. A high-cost space transportation program is potentially the most crippling barrier to such a space power program. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed. Over 120 students from 29 countries participated in this summer session. The results discussed in this paper, therefore, represent the efforts of many nations.

Progress update of NASA's free-piston Stirling space power converter technology project

NASA Technical Reports Server (NTRS)

Dudenhoefer, James E.; Winter, Jerry M.; Alger, Donald

1992-01-01

A progress update is presented of the NASA LeRC Free-Piston Stirling Space Power Converter Technology Project. This work is being conducted under NASA's Civil Space Technology Initiative (CSTI). The goal of the CSTI High Capacity Power Element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space initiatives. Efforts are focused upon increasing system power output and system thermal and electric energy conversion efficiency at least five fold over current SP-100 technology, and on achieving systems that are compatible with space nuclear reactors. This paper will discuss progress toward 1050 K Stirling Space Power Converters. Fabrication is nearly completed for the 1050 K Component Test Power Converter (CTPC); results of motoring tests of the cold end (525 K), are presented. The success of these and future designs is dependent upon supporting research and technology efforts including heat pipes, bearings, superalloy joining technologies, high efficiency alternators, life and reliability testing, and predictive methodologies. This paper will compare progress in significant areas of component development from the start of the program with the Space Power Development Engine (SPDE) to the present work on CTPC.

Useful information provided by graphic displays of automated cell counter in hematological malignancies.

PubMed

Gupta, Monica; Chauhan, Kriti; Singhvi, Tanvi; Kumari, Manisha; Grover, Rajesh Kumar

2018-01-21

Automated cell counters have become more and more sophisticated with passing years. The numerical and graphic data both provide useful clues for suspecting a diagnosis especially when the workload is very high. We present our experience of useful information provided by graphic displays of an automated cell counter in hematological malignancies in a cancer hospital where a large number of complete blood count (CBC) requests are received either before or during chemotherapy. This study was conducted to assess the usefulness of hematology cell counter, viz. WBC-Diff (WBC differential), WBC/BASO (WBC basophil) and IMI (immature myeloid information) channel scatter plots, and the flaggings generated in various hematological malignancies. The graphic displays have been compiled over a period of 1 year (October 2015-September 2016) from blood samples of various solid and hematological malignancies (approximately 400 per day) received for routine CBC in the laboratory. Approximately 50 000 scattergrams have been analyzed during the study period. The findings were confirmed by peripheral blood smear examination. The scattergram analysis on XE-2100 is very sensitive as well as specific for diagnosing acute leukemia, viz. acute myeloid leukemia, acute lymphoblastic leukemia; chronic myeloproliferative disorders, viz. chronic myeloid leukemia; and chronic lymphoproliferative disorder especially chronic lymphocytic leukemia. It is suggested that the laboratories using the hematology analyzers be aware of graphic display patterns in addition to flaggings generated which provide additional information and give clue toward the diagnosis even before peripheral smear examination. © 2018 Wiley Periodicals, Inc.

Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors.

PubMed

Borai, Anwar; Livingstone, Callum; Alsobhi, Enaam; Al Sofyani, Abeer; Balgoon, Dalal; Farzal, Anwar; Almohammadi, Mohammed; Al-Amri, Abdulafattah; Bahijri, Suhad; Alrowaili, Daad; Bassiuni, Wafaa; Saleh, Ayman; Alrowaili, Norah; Abdelaal, Mohamed

2017-04-01

Whole blood donation has immunomodulatory effects, and most of these have been observed at short intervals following blood donation. This study aimed to investigate the impact of whole blood donation on lymphocyte subsets over a typical inter-donation interval. Healthy male subjects were recruited to study changes in complete blood count (CBC) (n = 42) and lymphocyte subsets (n = 16) before and at four intervals up to 106 days following blood donation. Repeated measures ANOVA were used to compare quantitative variables between different visits. Following blood donation, changes in CBC and erythropoietin were as expected. The neutrophil count increased by 11.3% at 8 days (p < .001). Novel changes were observed in lymphocyte subsets as the CD4/CD8 ratio increased by 9.2% (p < .05) at 8 days and 13.7% (p < .05) at 22 days. CD16-56 cells decreased by 16.2% (p < .05) at 8 days. All the subsets had returned to baseline by 106 days. Regression analysis showed that the changes in CD16-56 cells and CD4/CD8 ratio were not significant (Wilk's lambda = 0.15 and 0.94, respectively) when adjusted for BMI. In conclusion, following whole blood donation, there are transient changes in lymphocyte subsets. The effect of BMI on lymphocyte subsets and the effect of this immunomodulation on the immune response merit further investigation.

Systematic donor blood qualification by flow cytometry would have been able to avoid CLL-type MBL transmission after unrelated hematopoietic stem cell transplantation.

PubMed

Ferrand, Christophe; Garnache-Ottou, Francine; Collonge-Rame, Marie Agnès; Larosa, Fabrice; Blanc, Michel; Behar, Catherine; Giannoli, Catherine; Garnier, Frédérico; Tiberghien, Pierre; Deconinck, Eric; Rohrlich, Pierre Simon

2012-03-01

The current screening for eligibility of unrelated volunteer marrow donors comprises a complete clinical check-up, a blood CBC and serum protein immunoelectrophoresis. This allows to eliminate acute leukemias, myeloproliferative and myelodysplastic disorders, myelomas and MGUS. To date, the risk of transmission of chronic lymphocytic leukemia (CLL) disease is only evaluated by the clinical evaluation and CBC. We report here the case of a CLL-type MBL disease occurring in a 12-year-old boy after unrelated BMT. Deep biological investigations, as Immunophenotyping, cytogenetic and molecular biology allow us to determine the donor origin of the CLL clone. In 2010, 14.2% donor (105/737) for unrelated hematopoietic stem cell transplantation were over 45y. It is currently estimated (USA) that 1 in 210 men and women will be diagnosed with CLL during their lifetime. Given the long asymptomatic phase of CLL, this raises the case for a detection strategy analog to that used for MGUS and myeloma through serum protein electrophoresis. This case-report, to our knowledge, of a CLL-type MBL unrelated donor-to-recipient transmission through BMT raises ethical and practical questions, such as the proper information about disease transmission risk. The cost-effectiveness of a systematic peripheral blood Immunophenotyping in donors elder than 40y at time of stem cell donation should be evaluated. © 2012 John Wiley & Sons A/S.

Differences in receptor binding affinity of several phytocannabinoids do not explain their effects on neural cell cultures.

PubMed

Rosenthaler, Sarah; Pöhn, Birgit; Kolmanz, Caroline; Huu, Chi Nguyen; Krewenka, Christopher; Huber, Alexandra; Kranner, Barbara; Rausch, Wolf-Dieter; Moldzio, Rudolf

2014-01-01

Phytocannabinoids are potential candidates for neurodegenerative disease treatment. Nonetheless, the exact mode of action of major phytocannabinoids has to be elucidated, but both, receptor and non-receptor mediated effects are discussed. Focusing on the often presumed structure-affinity-relationship, Ki values of phytocannabinoids cannabidiol (CBD), cannabidivarin (CBDV), cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), THC acid (THCA) and THC to human CB1 and CB2 receptors were detected by using competitive inhibition between radioligand [(3)H]CP-55,940 and the phytocannabinoids. The resulting Ki values to CB1 range from 23.5 nM (THCA) to 14711 nM (CBDV), whereas Ki values to CB2 range from 8.5 nM (THC) to 574.2 nM (CBDV). To study the relationship between binding affinity and effects on neurons, we investigated possible CB1 related cytotoxic properties in murine mesencephalic primary cell cultures and N18TG2 neuroblastoma cell line. Most of the phytocannabinoids did not affect the number of dopaminergic neurons in primary cultures, whereas propidium iodide and resazurin formation assays revealed cytotoxic properties of CBN, CBDV and CBG. However, THC showed positive effects on N18TG2 cell viability at a concentration of 10 μM, whereas CBC and THCA also displayed slightly positive activities. These findings are not linked to the receptor binding affinity therewith pointing to another mechanism than a receptor mediated one. [Corrected] Copyright © 2014 Elsevier Inc. All rights reserved.

Specimen rejection in laboratory medicine: Necessary for patient safety?

PubMed

Dikmen, Zeliha Gunnur; Pinar, Asli; Akbiyik, Filiz

2015-01-01

The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the rejection criteria of the laboratory. In this study, we aimed to evaluate the sample rejection ratios according to the types of pre-preanalytical errors and collection areas. The samples sent to the emergency laboratory were recorded during 12 months between January to December, 2013 in which 453,171 samples were received and 27,067 specimens were rejected. Rejection ratios was 2.5% for biochemistry tests, 3.2% for complete blood count (CBC), 9.8% for blood gases, 9.2% for urine analysis, 13.3% for coagulation tests, 12.8% for therapeutic drug monitoring, 3.5% for cardiac markers and 12% for hormone tests. The most frequent rejection reasons were fibrin clots (28%) and inadequate volume (9%) for biochemical tests. Clotted samples (35%) and inadequate volume (13%) were the major causes for coagulation tests, blood gas analyses and CBC. The ratio of rejected specimens was higher in the EDs (40%) compared to ICUs (30%) and inpatient services (28%). The highest rejection ratio was observed in neurology ICU (14%) among the ICUs and internal medicine inpatient service (10%) within inpatient clinics. We detected an overall specimen rejection rate of 6% in emergency laboratory. By documentation of rejected samples and periodic training of healthcare personnel, we expect to decrease sample rejection ratios below 2%, improve total quality management of the emergency laboratory and promote patient safety.

Early diagnosis of severe combined immunodeficiency (SCID) in Turkey: a pilot study.

PubMed

Can, Ceren; Hamilçıkan, Şahin; Can, Emrah

2017-08-29

Severe combined immunodeficiency (SCID) is a neonatal emergency. As the T-cell receptor excision circles (TREC) test is not cost effective for neonatal screening of SCID in developing countries, this pilot study's objective aimed at identifying preliminary data to enable SCID identification in the general population. This observational study was performed in Bagcılar Training and Research Hospital, Istanbul, Turkey. Cord-blood complete blood count (CBC) was recorded in all neonates included in the study. Absolute lymphopenia was considered in cord-blood samples if the absolute lymphocyte count was less than 2500/mm 3 . A control blood count was performed 1-month later for cases with detected lymphopenia. A total of 2945 term neonates were included in the study. Absolute lymphopenia was found in nine (0.3%) neonates, while 2936 (99.7%) had an absolute lymphocytic count above 2.5 × 10 3 /mm 3 . The mean counts of red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), platelets (PLT), and monocytes in the lymphopenia group were not found to significantly differ from the non-lymphopenia group. However, there were significantly lower mean white blood cell (WBC), lymphocyte, and neutrophil counts between the groups (p < .05). Absolute lymphopenia detected using CBC analysis is a simple, easier, more non-invasive, and cheaper method than the TREC method for detection of SCID neonates, and this method may prove to be a useful alternative, especially in developing countries.

Nomograms Predicting Platinum Sensitivity, Progression-Free Survival, and Overall Survival Using Pretreatment Complete Blood Cell Counts in Epithelial Ovarian Cancer

PubMed Central

Paik, E Sun; Sohn, Insuk; Baek, Sun-Young; Shim, Minhee; Choi, Hyun Jin; Kim, Tae-Joong; Choi, Chel Hun; Lee, Jeong-Won; Kim, Byoung-Gie; Lee, Yoo-Young; Bae, Duk-Soo

2017-01-01

Purpose This study was conducted to evaluate the prognostic significance of pre-treatment complete blood cell count (CBC), including white blood cell (WBC) differential, in epithelial ovarian cancer (EOC) patients with primary debulking surgery (PDS) and to develop nomograms for platinum sensitivity, progression-free survival (PFS), and overall survival (OS). Materials and Methods We retrospectively reviewed the records of 757 patients with EOC whose primary treatment consisted of surgical debulking and chemotherapy at Samsung Medical Center from 2002 to 2012. We subsequently created nomograms for platinum sensitivity, 3-year PFS, and 5-year OS as prediction models for prognostic variables including age, stage, grade, cancer antigen 125 level, residual disease after PDS, and pre-treatment WBC differential counts. The models were then validated by 10-fold cross-validation (CV). Results In addition to stage and residual disease after PDS, which are known predictors, lymphocyte and monocyte count were found to be significant prognostic factors for platinum-sensitivity, platelet count for PFS, and neutrophil count for OS on multivariate analysis. The area under the curves of platinum sensitivity, 3-year PFS, and 5-year OS calculated by the 10-fold CV procedure were 0.7405, 0.8159, and 0.815, respectively. Conclusion Prognostic factors including pre-treatment CBC were used to develop nomograms for platinum sensitivity, 3-year PFS, and 5-year OS of patients with EOC. These nomograms can be used to better estimate individual outcomes. PMID:27669704

Nomograms Predicting Platinum Sensitivity, Progression-Free Survival, and Overall Survival Using Pretreatment Complete Blood Cell Counts in Epithelial Ovarian Cancer.

PubMed

Paik, E Sun; Sohn, Insuk; Baek, Sun-Young; Shim, Minhee; Choi, Hyun Jin; Kim, Tae-Joong; Choi, Chel Hun; Lee, Jeong-Won; Kim, Byoung-Gie; Lee, Yoo-Young; Bae, Duk-Soo

2017-07-01

This study was conducted to evaluate the prognostic significance of pre-treatment complete blood cell count (CBC), including white blood cell (WBC) differential, in epithelial ovarian cancer (EOC) patients with primary debulking surgery (PDS) and to develop nomograms for platinum sensitivity, progression-free survival (PFS), and overall survival (OS). We retrospectively reviewed the records of 757 patients with EOC whose primary treatment consisted of surgical debulking and chemotherapy at Samsung Medical Center from 2002 to 2012. We subsequently created nomograms for platinum sensitivity, 3-year PFS, and 5-year OS as prediction models for prognostic variables including age, stage, grade, cancer antigen 125 level, residual disease after PDS, and pre-treatment WBC differential counts. The models were then validated by 10-fold cross-validation (CV). In addition to stage and residual disease after PDS, which are known predictors, lymphocyte and monocyte count were found to be significant prognostic factors for platinum-sensitivity, platelet count for PFS, and neutrophil count for OS on multivariate analysis. The area under the curves of platinum sensitivity, 3-year PFS, and 5-year OS calculated by the 10-fold CV procedure were 0.7405, 0.8159, and 0.815, respectively. Prognostic factors including pre-treatment CBC were used to develop nomograms for platinum sensitivity, 3-year PFS, and 5-year OS of patients with EOC. These nomograms can be used to better estimate individual outcomes.

The Effect of Citrus Essential Oils and Their Constituents on Growth of Xanthomonas citri subsp. citri.

PubMed

Mirzaei-Najafgholi, Hossein; Tarighi, Saeed; Golmohammadi, Morteza; Taheri, Parissa

2017-04-14

Citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. citri ( Xcc ), is the most devastating of the citrus diseases worldwide. During our study, we found that Essential oils (EOs) of some citrus cultivars are effective on Xcc . Therefore, it prompted us to determine the plant metabolites responsible for the antibacterial properties. We obtained EOs from some locally cultivated citrus by using a Clevenger apparatus and their major constituents were identified by gas chromatography/mass spectrometry (GC-MS). The effect of Citrus aurantium , C. aurantifolia , Fortunella sp. EOs and their major constituents were evaluated against Xcc -KVXCC1 using a disk diffusion assay. Minimal inhibitory and bactericidal concentration of the EOs and their constituents were determined using the broth microdilution method. C. aurantium , C. aurantifolia Eos, and their major constituents including citral, linalool, citronellal, geraniol, α-terpineol, and linalyl acetate indicated antibacterial effects against Xcc . The C. aurantifolia EO and citral showed the highest antibacterial activity among the tested EOs and constituents with inhibition zones of 15 ± 0.33 mm and 16.67 ± 0.88 mm, respectively. Synergistic effects of the constituents were observed between α-terpineol-citral, citral-citronellal, citral-geraniol, and citronellal-geraniol by using a microdilution checkerboard assay. Transmission electron microscopy revealed that exposure of Xcc cells to citral caused cell wall damage and altered cytoplasmic density. We introduced C. aurantifolia and C. aurantium EOs, and their constituents citral, α-terpineol, citronellal, geraniol, and linalool as possible control agents for CBC.

The efficacy of the Peginterferon treatment in chronic hepatitis HDV and compensate liver cirrhosis.

PubMed

Tugui, Letitia; Dumitru, M; Iacob, Speranta; Gheorghe, Liana; Preda, Carmen; Dinu, Ioana; Becheanu, G; Dumbrava, Mona; Nicolae, Ioana; Andrei, Adriana; Lupu, A; Diculescu, M

2014-01-01

To evaluate the efficiency of the treatment with Peginterferon alfa 2a 180 mcg/week, 48 weeks in patients with chronic hepatitis or compensated liver cirrhosis HDV and predictive factors of response to treatment. Prospective study that enrolled 50 patients with chronic hepatitis or compensated cirrhosis HDV between the 1st of January 2011 - 3st of December 2011. The diagnosis of chronic HDV infection was made based on the presence of detectable anti HDV IgG antibodies and HDV-RNA. Patients were evaluated at baseline by CBC, liver function tests, HBV profile, HDV RNA, and by liver biopsy/Fibrotest for evaluating fibrosis and necroinflammatory activity. At 24 weeks CBC (count blood cells), liver function tests, quantitative HBsAg and at 48 and 72 weeks biochemical tests, HDV RNA, HBV DNA, quantitative HBsAg, were performed. Adverse reactions to the treatment were recorded. SVR (sustained virologic response) was recorded in 12 patients (24%) and biochemical response in 28 patients (56%). SVR was correlated with low-grade fibrosis, age, the aminotransferase value and the value of HBsAg at the beginning of the treatment. In week 48 HDV RNA was undetectable in 20 patients (40%). The therapy was well tolerated, except two patients for whom the discontinuation of the treatment was decided for severe exacerbation of cytolysis, respectively hepatic decompensation. In a representative group of patients, the treatment with Peginterferon once again proves its efficacy in treating chronic HDV.

Patient centered decision making: use of conjoint analysis to determine risk-benefit trade-offs for preference sensitive treatment choices.

PubMed

Wilson, Leslie; Loucks, Aimee; Bui, Christine; Gipson, Greg; Zhong, Lixian; Schwartzburg, Amy; Crabtree, Elizabeth; Goodin, Douglas; Waubant, Emmanuelle; McCulloch, Charles

2014-09-15

Understanding patient preferences facilitates shared decision-making and focuses on patient-centered outcomes. Little is known about relapsing-remitting multiple sclerosis (RRMS) patient preferences for disease modifying therapies (DMTs). We use choice based conjoint (CBC) analysis to calculate patient preferences for risk/benefit trade-offs for hypothetical DMTs. Patients with RRMS were surveyed between 2012 and 2013. Our CBC survey mimicked the decision-making process and trade-offs of patients choosing DMTs, based on all possible DMT attributes. Mixed-effects logistic regression analyzed preferences. We estimated maximum acceptable risk trade-offs for various DMT benefits. Severe side-effect risks had the biggest impact on patient preference with a 1% risk, decreasing patient preference five-fold compared to no risk. (OR=0.22, p<0.001). Symptom improvement was the most preferred benefit (OR=3.68, p<0.001), followed by prevention of progression of 10 years (OR=2.4, p<0.001). Daily oral administration had the third highest DMT preference rating (OR=2.08, p<0.001). Patients were willing to accept 0.08% severe risk for a year delayed relapse, and 0.22% for 4 vs 2 year prevented progression. We provided patient preferences and risk-benefit trade-offs for attributes of all available DMTs. Evaluation of patient preferences is a key step in shared decision making and may significantly impact early drug initiation and compliance. Copyright © 2014 Elsevier B.V. All rights reserved.

Myocardial protection during minimally invasive cardiac surgery through right mini-thoracotomy.

PubMed

De Palo, Micaela; Guida, Pietro; Mastro, Florinda; Nanna, Daniela; Quagliara, Teresa A P; Rociola, Ruggiero; Lionetti, Giosuè; Paparella, Domenico

2017-04-01

Myocardial damage is an independent predictor of adverse outcome following cardiac surgery and myocardial protection is one of the key factors to achieve successful outcomes. Cardioplegia with Custodiol is currently the most used cardioplegia during minimally invasive cardiac surgery (MICS). Different randomized controlled trials compared blood and Custodiol cardioplegia in the context of traditional cardiac surgery. No data are available for MICS. The aim of this study was to compare the efficacy of cold blood versus Custodiol cardioplegia during MICS. We retrospectively evaluated 90 patients undergoing MICS through a right mini-thoracotomy in a three-year period. Myocardial protection was performed using cold blood (44 patients, CBC group) or Custodiol (46 patients, Custodiol group) cardioplegia, based on surgeon preference and complexity of surgery. The primary outcomes were post-operative cardiac troponin I (cTnI) and creatine kinase MB (CKMB) serum release and the incidence of Low Cardiac Output Syndrome (LCOS). Aortic cross-clamp and cardiopulmonary bypass times were higher in the Custodiol group. No difference was observed in myocardial injury enzyme release (peak cTnI value was 18±46 ng/ml in CBC and 21±37 ng/ml in Custodiol; p=0.245). No differences were observed for mortality, LCOS, atrial or ventricular arrhythmias onset, transfusions, mechanical ventilation time duration, intensive care unit and total hospital stay. Custodiol and cold blood cardioplegic solutions seem to assure similar myocardial protection in patients undergoing cardiac surgery through a right mini-thoracotomy approach.

Space and energy. [space systems for energy generation, distribution and control

NASA Technical Reports Server (NTRS)

Bekey, I.

1976-01-01

Potential contributions of space to energy-related activities are discussed. Advanced concepts presented include worldwide energy distribution to substation-sized users using low-altitude space reflectors; powering large numbers of large aircraft worldwide using laser beams reflected from space mirror complexes; providing night illumination via sunlight-reflecting space mirrors; fine-scale power programming and monitoring in transmission networks by monitoring millions of network points from space; prevention of undetected hijacking of nuclear reactor fuels by space tracking of signals from tagging transmitters on all such materials; and disposal of nuclear power plant radioactive wastes in space.

Status of NASA's Stirling Space Power Converter Program

NASA Technical Reports Server (NTRS)

Dudenhoefer, James E.; Winter, Jerry M.

1991-01-01

An overview is presented of the NASA-Lewis Free-Piston Stirling Space Power Convertor Technology Program. The goal is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space initiatives. Efforts are focused upon increasing system power output and system thermal and electric energy conversion efficiency at least fivefold over current SP-100 technology, and on achieving systems that are compatible with space nuclear reactors. Stirling experience in space and progress toward 1050 and 1300 K Stirling Space Power Converters is discussed. Fabrication is nearly completed for the 1050 K Component Test Power Converters (CTPC); results of motoring tests of cold end (525 K), are presented. The success of these and future designs is dependent upon supporting research and technology efforts including heat pipes, bearings, superalloy joining technologies, high efficiency alternators, life and reliability testing and predictive methodologies. An update is provided of progress in some of these technologies leading off with a discussion of free-piston Stirling experience in space.

Nuclear Safety for Space Systems

NASA Astrophysics Data System (ADS)

Offiong, Etim

2010-09-01

It is trite, albeit a truism, to say that nuclear power can provide propulsion thrust needed to launch space vehicles and also, to provide electricity for powering on-board systems, especially for missions to the Moon, Mars and other deep space missions. Nuclear Power Sources(NPSs) are known to provide more capabilities than solar power, fuel cells and conventional chemical means. The worry has always been that of safety. The earliest superpowers(US and former Soviet Union) have designed and launched several nuclear-powered systems, with some failures. Nuclear failures and accidents, however little the number, could be far-reaching geographically, and are catastrophic to humans and the environment. Building on the numerous research works on nuclear power on Earth and in space, this paper seeks to bring to bear, issues relating to safety of space systems - spacecrafts, astronauts, Earth environment and extra terrestrial habitats - in the use and application of nuclear power sources. It also introduces a new formal training course in Space Systems Safety.

Improving Safety and Reliability of Space Auxiliary Power Units

NASA Technical Reports Server (NTRS)

Viterna, Larry A.

1998-01-01

Auxiliary Power Units (APU's) play a critical role in space vehicles. On the space shuttle, APU's provide the hydraulic power for the aerodynamic control surfaces, rocket engine gimballing, landing gear, and brakes. Future space vehicles, such as the Reusable Launch Vehicle, will also need APU's to provide electrical power for flight control actuators and other vehicle subsystems. Vehicle designers and mission managers have identified safety, reliability, and maintenance as the primary concerns for space APU's. In 1997, the NASA Lewis Research Center initiated an advanced technology development program to address these concerns.

The NASA research and technology program on space power: A key element of the Space Exploration Initiative

NASA Technical Reports Server (NTRS)

Bennett, Gary L.; Brandhorst, Henry W., Jr.; Atkins, Kenneth L.

1991-01-01

In July 1989, President Bush announced his space exploration initiative of going back to the Moon to stay and then going to Mars. Building upon its ongoing research and technology base, NASA has established an exploration technology program to develop the technologies needed for piloted missions to the Moon and Mars. A key element for the flights and for the planned bases is power. The NASA research and technology program on space power encompasses power sources, energy storage, and power management.

Isotope Brayton space power systems and their technology

NASA Technical Reports Server (NTRS)

Schwartz, H.

1972-01-01

The objectives of the NASA Brayton Space Power Program and the advantages of achieving an isotope Brayton space power system are enumerated. The paper describes the 2-15 kWe Brayton engine, its subsystems, and major components and summarizes the status of the test program. Two areas of Brayton constituent technology are discussed-gas bearings and heat exchangers. A summary is given of a 500-2500 W isotope Brayton space power system study that showed very attractive performance, simplicity, and low cost for a system in this power range.

Atomic power in space: A history

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-03-01

''Atomic Power in Space,'' a history of the Space Isotope Power Program of the United States, covers the period from the program's inception in the mid-1950s through 1982. Written in non-technical language, the history is addressed to both the general public and those more specialized in nuclear and space technologies. 19 figs., 3 tabs.

Nuclear Reactors for Space Power, Understanding the Atom Series.

ERIC Educational Resources Information Center

Corliss, William R.

The historical development of rocketry and nuclear technology includes a specific description of Systems for Nuclear Auxiliary Power (SNAP) programs. Solar cells and fuel cells are considered as alternative power supplies for space use. Construction and operation of space power plants must include considerations of the transfer of heat energy to…

46 CFR 92.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2013 CFR

2013-10-01

... electric power. 92.05-15 Section 92.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Segregation of spaces containing the emergency source of electric power. (a) The provisions of this section... the emergency source of electric power, or vital components thereof, adjoins a space containing either...

46 CFR 92.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2012 CFR

2012-10-01

... electric power. 92.05-15 Section 92.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Segregation of spaces containing the emergency source of electric power. (a) The provisions of this section... the emergency source of electric power, or vital components thereof, adjoins a space containing either...

46 CFR 92.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2014 CFR

2014-10-01

... electric power. 92.05-15 Section 92.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Segregation of spaces containing the emergency source of electric power. (a) The provisions of this section... the emergency source of electric power, or vital components thereof, adjoins a space containing either...

46 CFR 190.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2014 CFR

2014-10-01

... electric power. 190.05-15 Section 190.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Segregation of spaces containing the emergency source of electric power. (a) When a compartment containing the emergency source of electric power, or vital components thereof, adjoins a space containing either the ship...

46 CFR 190.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2013 CFR

2013-10-01

... electric power. 190.05-15 Section 190.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Segregation of spaces containing the emergency source of electric power. (a) When a compartment containing the emergency source of electric power, or vital components thereof, adjoins a space containing either the ship...

46 CFR 190.05-15 - Segregation of spaces containing the emergency source of electric power.

Code of Federal Regulations, 2012 CFR

2012-10-01

... electric power. 190.05-15 Section 190.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Segregation of spaces containing the emergency source of electric power. (a) When a compartment containing the emergency source of electric power, or vital components thereof, adjoins a space containing either the ship...

NASA Growth Space Station missions and candidate nuclear/solar power systems

NASA Technical Reports Server (NTRS)

Heller, Jack A.; Nainiger, Joseph J.

1987-01-01

A brief summary is presented of a NASA study contract and in-house investigation on Growth Space Station missions and appropriate nuclear and solar space electric power systems. By the year 2000 some 300 kWe will be needed for missions and housekeeping power for a 12 to 18 person Station crew. Several Space Station configurations employing nuclear reactor power systems are discussed, including shielding requirements and power transmission schemes. Advantages of reactor power include a greatly simplified Station orientation procedure, greatly reduced occultation of views of the earth and deep space, near elimination of energy storage requirements, and significantly reduced station-keeping propellant mass due to very low drag of the reactor power system. The in-house studies of viable alternative Growth Space Station power systems showed that at 300 kWe a rigid silicon solar cell array with NiCd batteries had the highest specific mass at 275 kg/kWe, with solar Stirling the lowest at 40 kg/kWe. However, when 10 year propellant mass requirements are factored in, the 300 kWe nuclear Stirling exhibits the lowest total mass.

Programmatic status of NASA's CSTI high capacity power Stirling space power converter program

NASA Technical Reports Server (NTRS)

Dudenhoefer, James E.

1990-01-01

An overview is presented of the NASA Lewis Research Center Free-Piston Stirling Space Power Converter Technology Development Program. This work is being conducted under NASA's Civil Space Technology Initiative (CSTI). The goal of the CSTI High Capacity Power element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space initiatives. Efforts are focused upon increasing system thermal and electric energy conversion efficiency at least fivefold over current SP-100 technology, and on achieving systems that are compatible with space nuclear reactors. The status of test activities with the Space Power Research Engine (SPRE) is discussed. Design deficiencies are gradually being corrected and the power converter is now outputting 11.5 kWe at a temperature ratio of 2 (design output is 12.5 kWe). Detail designs were completed for the 1050 K Component Test Power Converter (CTPC). The success of these and future designs is dependent upon supporting research and technology efforts including heat pipes, gas bearings, superalloy joining technologies and high efficiency alternators. An update of progress in these technologies is provided.

Nano Goes Magnetic to Attract Big Business

NASA Technical Reports Server (NTRS)

2006-01-01

Glenn Research Center has combined state-of-the-art electrical designs with complex, computer-aided analyses to develop some of today s most advanced power systems, in space and on Earth. The center s Power and On-Board Propulsion Technology Division is the brain behind many of these power systems. For space, this division builds technologies that help power the International Space Station, the Hubble Space Telescope, and Earth-orbiting satellites. For Earth, it has woven advanced aerospace power concepts into commercial energy applications that include solar and nuclear power generation, battery and fuel cell energy storage, communications and telecommunications satellites, cryocoolers, hybrid and electric vehicles, and heating and air-conditioning systems.

Toward an electrical power utility for space exploration

NASA Technical Reports Server (NTRS)

Bercaw, Robert W.

1989-01-01

Future electrical power requirements for space exploration are discussed. Megawatts of power with enough reliability for multi-year missions and with enough flexibility to adapt to needs unanticipated at design time are some of the criteria which space power systems must be able to meet. The reasons for considering the power management and distribution in the various systems, from a total mission perspective rather than simply extrapolating current spacecraft design practice, are discussed. A utility approach to electric power integrating requirements from a broad selection of current development programs, with studies in which both space and terrestrial technologies are conceptually applied to exploration mission scenarios, is described.

Remotely Powered Reconfigurable Receiver for Extreme Sensing Platforms

NASA Technical Reports Server (NTRS)

Sheldon, Douglas J. (Inventor)

2017-01-01

Unmanned space programs are currently used to enable scientists to explore and research the furthest reaches of outer space. Systems and methods for low power communication devices in accordance with embodiments of the invention are disclosed, describing a wide variety of low power communication devices capable of remotely collecting, processing, and transmitting data from outer space in order to further mankind's goal of exploring the cosmos. Many embodiments of the invention include a Flash-based FPGA, an energy-harvesting power supply module, a sensor module, and a radio module. By utilizing technologies that withstand the harsh environment of outer space, more reliable low power communication devices can be deployed, enhancing the quality and longevity of the low power communication devices, enabling more data to be gathered and aiding in the exploration of outer space.

Atomic Power in Space: A History

DOE R&D Accomplishments Database

1987-03-01

"Atomic Power in Space," a history of the Space Isotope Power Program of the United States, covers the period from the program's inception in the mid-1950s through 1982. Written in non-technical language, the history is addressed to both the general public and those more specialized in nuclear and space technologies. Interplanetary space exploration successes and achievements have been made possible by this technology, for which there is no known substitue.

Space Solar Power Technology Demonstration for Lunar Polar Applications: Laser-Photovoltaic Wireless Power Transmission

NASA Technical Reports Server (NTRS)

Henley, M. W.; Fikes, J. C.; Howell, J.; Mankins, J. C.; Howell, Joe T. (Technical Monitor)

2002-01-01

Space Solar Power technology offers unique benefits for near-term NASA space science missions, which can mature this technology for other future applications. "Laser-Photo-Voltaic Wireless Power Transmission" (Laser-PV WPT) is a technology that uses a laser to beam power to a photovoltaic receiver, which converts the laser's light into electricity. Future Laser-PV WPT systems may beam power from Earth to satellites or large Space Solar Power satellites may beam power to Earth, perhaps supplementing terrestrial solar photo-voltaic receivers. In a near-term scientific mission to the moon, Laser-PV WPT can enable robotic operations in permanently shadowed lunar polar craters, which may contain ice. Ground-based technology demonstrations are proceeding, to mature the technology for this initial application, in the moon's polar regions.

Solar power satellite system definition study, phase 2.

NASA Technical Reports Server (NTRS)

1979-01-01

A program plan for the Solar Power Satellite Program is presented. The plan includes research, development, and evaluation phase, engineering and development and cost verification phase, prototype construction, and commercialization. Cost estimates and task requirements are given for the following technology areas: (1) solar arrays; (2) thermal engines and thermal systems; (3) power transmission (to earth); (4) large space structures; (5) materials technology; (6) system control; (7) space construction; (8) space transportation; (9) power distribution, and space environment effects.

Future Photovoltaic Power Generation for Space-Based Power Utilities

NASA Technical Reports Server (NTRS)

Bailey, Sheila; Landis, Geoffrey; Hepp, Aloysius; Raffaelle, Ryne

2002-01-01

This paper discusses requirements for large earth orbiting power stations that can serve as central utilities for other orbiting spacecraft, or for beaming power to the earth itself. The current state of the art of space solar cells, and a variety of both evolving thin film cells as well as new technologies that may impact the future choice of space solar cells for high power mission applications are addressed.

Economical space power systems

NASA Technical Reports Server (NTRS)

Burkholder, J. H.

1980-01-01

A commercial approach to design and fabrication of an economical space power system is investigated. Cost projections are based on a 2 kW space power system conceptual design taking into consideration the capability for serviceability, constraints of operation in space, and commercial production engineering approaches. A breakdown of the system design, documentation, fabrication, and reliability and quality assurance estimated costs are detailed.

A Study on Contrasts. Similarities and Differences Between Development of Airpower and Space Power

DTIC Science & Technology

1998-04-01

Army when he favored building up the Air Forces. Power will follow the money . Until outsiders redirect resources into space, it will remain in the...leadership commitment to the growth and potential of America’s space power. As 42 Builder said, power will follow the money . But is money, by itself, enough

Nuclear systems for space power and propulsion

NASA Technical Reports Server (NTRS)

Klein, M.

1971-01-01

As exploration and utilization of space proceeds through the 1970s, 1980s, and beyond, spacecraft in earth orbit will become increasingly larger, spacecraft will travel deeper into space, and space activities will involve more complex operations. These trends require increasing amounts of energy for power and propulsion. The role to be played by nuclear energy is presented, including plans for deep space missions using radioisotope generators, the reactor power systems for earth orbiting stations and satellites, and the role of nuclear propulsion in space transportation.

Space power technology into the 21st century

NASA Technical Reports Server (NTRS)

Faymon, K. A.; Fordyce, J. S.

1984-01-01

This paper discusses the space power systems of the early 21st century. The focus is on those capabilities which are anticipated to evolve from today's state-of-the-art and the technology development programs presently in place or planned for the remainder of the century. The power system technologies considered include solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state-of-the-art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and earth to space and space to space transportation systems. The various space power/energy system technologies anticipated to be operational by the early 21st century are matched to these missions.

Space power technology into the 21st Century

NASA Technical Reports Server (NTRS)

Faymon, K. A.; Fordyce, J. S.

1983-01-01

The space power systems of the early 21st century are discussed. The capabilities which are anticipated to evolve from today's state of the art and the technology development programs presently in place or planned for the remainder of the century are emphasized. The power system technologies considered include: solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include: nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state of the art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned Earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and Earth to space and space to space transportation systems. The various space power/energy system technologies which are anticipated to be operational by the early 21st century are matched to these missions.

Evolutionary growth for Space Station Freedom electrical power system

NASA Technical Reports Server (NTRS)

Marshall, Matthew Fisk; Mclallin, Kerry; Zernic, Mike

1989-01-01

Over an operational lifetime of at least 30 yr, Space Station Freedom will encounter increased Space Station user requirements and advancing technologies. The Space Station electrical power system is designed with the flexibility to accommodate these emerging technologies and expert systems and is being designed with the necessary software hooks and hardware scars to accommodate increased growth demand. The electrical power system is planned to grow from the initial 75 kW up to 300 kW. The Phase 1 station will utilize photovoltaic arrays to produce the electrical power; however, for growth to 300 kW, solar dynamic power modules will be utilized. Pairs of 25 kW solar dynamic power modules will be added to the station to reach the power growth level. The addition of solar dynamic power in the growth phase places constraints in the initial Space Station systems such as guidance, navigation, and control, external thermal, truss structural stiffness, computational capabilities and storage, which must be planned-in, in order to facilitate the addition of the solar dynamic modules.

Ground-Based and Space-Based Laser Beam Power Applications

NASA Technical Reports Server (NTRS)

Bozek, John M.

1995-01-01

A space power system based on laser beam power is sized to reduce mass, increase operational capabilities, and reduce complexity. The advantages of laser systems over solar-based systems are compared as a function of application. Power produced from the conversion of a laser beam that has been generated on the Earth's surface and beamed into cislunar space resulted in decreased round-trip time for Earth satellite electric propulsion tugs and a substantial landed mass savings for a lunar surface mission. The mass of a space-based laser system (generator in space and receiver near user) that beams down to an extraterrestrial airplane, orbiting spacecraft, surface outpost, or rover is calculated and compared to a solar system. In general, the advantage of low mass for these space-based laser systems is limited to high solar eclipse time missions at distances inside Jupiter. The power system mass is less in a continuously moving Mars rover or surface outpost using space-based laser technology than in a comparable solar-based power system, but only during dust storm conditions. Even at large distances for the Sun, the user-site portion of a space-based laser power system (e.g., the laser receiver component) is substantially less massive than a solar-based system with requisite on-board electrochemical energy storage.

Developments in space power components for power management and distribution

NASA Technical Reports Server (NTRS)

Renz, D. D.

1984-01-01

Advanced power electronic components development for space applications is discussed. The components described include transformers, inductors, semiconductor devices such as transistors and diodes, remote power controllers, and transmission lines.

Using Pre-Melted Phase Change Material to Keep Payloads in Space Warm for Hours without Power

NASA Technical Reports Server (NTRS)

Choi, Michael

2013-01-01

Adding phase change material (PCM) to a mission payload can maintain its temperature above the cold survival limit, without power, for several hours in space. For the International Space Station, PCM is melted by heaters just prior to the payload translation to the worksite when power is available. When power is cut off during the six-hour translation, the PCM releases its latent heat to make up the heat loss from the radiator(s) to space. For the interplanetary Probe, PCM is melted by heaters just prior to separation from the orbiter when power is available from the orbiter power system. After the Probe separates from the orbiter, the PCM releases its latent heat to make up the heat loss from the Probe exterior to space. Paraffin wax is a good PCM candidate.

Implementation of a virtual link between power system testbeds at Marshall Spaceflight Center and Lewis Research Center

NASA Technical Reports Server (NTRS)

Doreswamy, Rajiv

1990-01-01

The Marshall Space Flight Center (MSFC) owns and operates a space station module power management and distribution (SSM-PMAD) testbed. This system, managed by expert systems, is used to analyze and develop power system automation techniques for Space Station Freedom. The Lewis Research Center (LeRC), Cleveland, Ohio, has developed and implemented a space station electrical power system (EPS) testbed. This system and its power management controller are representative of the overall Space Station Freedom power system. A virtual link is being implemented between the testbeds at MSFC and LeRC. This link would enable configuration of SSM-PMAD as a load center for the EPS testbed at LeRC. This connection will add to the versatility of both systems, and provide an environment of enhanced realism for operation of both testbeds.

Autonomous power management and distribution

NASA Technical Reports Server (NTRS)

Dolce, Jim; Kish, Jim

1990-01-01

The goal of the Autonomous Power System program is to develop and apply intelligent problem solving and control to the Space Station Freedom's electric power testbed being developed at NASA's Lewis Research Center. Objectives are to establish artificial intelligence technology paths, craft knowledge-based tools and products for power systems, and integrate knowledge-based and conventional controllers. This program represents a joint effort between the Space Station and Office of Aeronautics and Space Technology to develop and demonstrate space electric power automation technology capable of: (1) detection and classification of system operating status, (2) diagnosis of failure causes, and (3) cooperative problem solving for power scheduling and failure recovery. Program details, status, and plans will be presented.

Trade studies for nuclear space power systems

NASA Technical Reports Server (NTRS)

Smith, John M.; Bents, David J.; Bloomfield, Harvey S.

1991-01-01

As human visions of space applications expand and as we probe further out into the universe, our needs for power will also expand, and missions will evolve which are enabled by nuclear power. A broad spectrum of missions which are enhanced or enabled by nuclear power sources have been defined. These include Earth orbital platforms, deep space platforms, planetary exploration, and terrestrial resource exploration. The recently proposed Space Exploration Initiative (SEI) to the Moon and Mars has more clearly defined these missions and their power requirements. Presented here are results of recent studies of radioisotope and nuclear reactor energy sources, combined with various energy conversion devices for Earth orbital applications, SEI lunar/Mars rovers, surface power, and planetary exploration.

Mechanisms of Exhaust Pollutants and Plume Formation in Continuous Combustion.

DTIC Science & Technology

1984-06-01

device. 4.1.3 Dilute Swirl Combustor (DSC) A swirl-stabilized geometry was developed to address the deficiencies observed with the swirl CBC geometry and...certain deficiencies were apparent in the ability of the model to predict experimental trends. For example: (1) The velocity profiles (Figure lOa) show that...25,000 Re - 50,000 HDF LA 1.1 0.55 Prediction 1.2 0.71 Flow Visualization 0.92 0.66 0 LCF LA 1.2 0.60 Prediction 1.3 0.70 5 J~55 -* - *7 2-- tK2

Overview of the 1986 free-piston Stirling SP-100 activities at the NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1986-01-01

An overview of the NASA Lewis Research Center SP-100 free-piston Stirling engine activities is presented. These activities include a free-piston Stirling space-power technology feasibility demonstration project as part of the SP-100 program being conducted in support of the Department of Defennse (DOD), Department of Energy (DOE), and NASA. The space-power Stirling advanced technology effort, under SP-100, addresses the status of the 25 kWe Space Power Demonstrator Engine (SPDE) including test results. Future space-power projections are presented along with a description of a study that will investigate the feasibility of scaling a single-cylinder free-piston Stirling space-power module to the 150 kW power range. Design parameters and conceptual design features will be presented for a 25 kWe, single-cylinder free-piston Stirling space-power converter. A description of a hydrodynamic gas bearing concept is presented whereby the displacer of a 1 kWe free-piston Stirling engine is modified to demonstrate the bearing concept. And finally the goals of a conceptual design for a 25 kWe Solar Advanced Stirling Conversion System capable of delivering electric power to an electric utility grid are discussed.

Overview of the 1986 free-piston Stirling SP-100 activities at the NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1986-01-01

An overview of the NASA Lewis Research Center SP-100 free-piston Stirling engine activities is presented. These activities include a free-piston Stirling space-power technology feasibility demonstration project as part of the SP-100 program being conducted in support of the Department of Defense (DOD), Department of Energy (DOE), and NASA. The space-power Stirling advanced technology effort, under SP-100, addresses the status of the 25 kWe Space Power Demonstrator Engine (SPDE) including test results. Future space-power projections are presented along with a description of a study that will investigate the feasibility of scaling a single-cylinder free-piston Stirling space-power module to the 150 kW power range. Design parameters and conceptual design features will be presented for a 25 kWe, single-cylinder free-piston Stirling space-power converter. A description of a hydrodynamic gas bearing concept is presented whereby the displacer of a 1 kWe free-piston Stirling engine is modified to demonstrate the bearing concept. And finally the goals of a conceptual design for a 25 kWe Solar Advanced Stirling Conversion System capable of delivering electric power to an electric utility grid are discussed.

SSP Power Management and Distribution

NASA Technical Reports Server (NTRS)

Lynch, Thomas H.; Roth, A. (Technical Monitor)

2000-01-01

Space Solar Power is a NASA program sponsored by Marshall Space Flight Center. The Paper presented here represents the architectural study of a large power management and distribution (PMAD) system. The PMAD supplies power to a microwave array for power beaming to an earth rectenna (Rectifier Antenna). The power is in the GW level.

Finite element analysis of space debris removal by high-power lasers

NASA Astrophysics Data System (ADS)

Xue, Li; Jiang, Guanlei; Yu, Shuang; Li, Ming

2015-08-01

With the development of space station technologies, irradiation of space debris by space-based high-power lasers, can locally generate high-temperature plasmas and micro momentum, which may achieve the removal of debris through tracking down. Considered typical square-shaped space debris of material Ti with 5cm×5cm size, whose thermal conductivity, density, specific heat capacity and emissivity are 7.62W/(m·°C), 4500kg/m3, 0.52J/(kg·°C) and 0.3,respectively, based on the finite element analysis of ANSYS, each irradiation of space debris by high-power lasers with power density 106W/m2 and weapons-grade lasers with power density 3000W/m2 are simulated under space environment, and the temperature curves due to laser thermal irradiation are obtained and compared. Results show only 2s is needed for high-power lasers to make the debris temperature reach to about 10000K, which is the threshold temperature for plasmas-state conversion. While for weapons-grade lasers, it is 13min needed. Using two line elements (TLE), and combined with the coordinate transformation from celestial coordinate system to site coordinate system, the visible period of space debris is calculated as 5-10min. That is, in order to remove space debris by laser plasmas, the laser power density should be further improved. The article provides an intuitive and visual feasibility analysis method of space debris removal, and the debris material and shape, laser power density and spot characteristics are adjustable. This finite element analysis method is low-cost, repeatable and adaptable, which has an engineering-prospective applications.

Low-Temperature Power Electronics Program

NASA Technical Reports Server (NTRS)

Patterson, Richard L.; Dickman, John E.; Hammoud, Ahmad; Gerber, Scott

1997-01-01

Many space and some terrestrial applications would benefit from the availability of low-temperature electronics. Exploration missions to the outer planets, Earth-orbiting and deep-space probes, and communications satellites are examples of space applications which operate in low-temperature environments. Space probes deployed near Pluto must operate in temperatures as low as -229 C. Figure 1 depicts the average temperature of a space probe warmed by the sun for various locations throughout the solar system. Terrestrial applications where components and systems must operate in low-temperature environments include cryogenic instrumentation, superconducting magnetic energy storage, magnetic levitation transportation system, and arctic exploration. The development of electrical power systems capable of extremely low-temperature operation represents a key element of some advanced space power systems. The Low-Temperature Power Electronics Program at NASA Lewis Research Center focuses on the design, fabrication, and characterization of low-temperature power systems and the development of supporting technologies for low-temperature operations such as dielectric and insulating materials, power components, optoelectronic components, and packaging and integration of devices, components, and systems.

Emphasis on High Power Lithium Ion Technology for Pulse-Load Operations: Terrestrial Developments Potential Benefits to Space Application

NASA Astrophysics Data System (ADS)

Fusalba, Florence; Chami, Marianne; Rey, Marlene; Moreau, Gilles; Reynier, Yvan; Azais, Philippe

2014-08-01

Currently Li-ion batteries are preferred to supply space missions owing to their large energy density. However, these batteries are designed for standard missions without high-power pulsed payloads, therefore for low C-rates profiles, and do not answer the needs of high- power space applications. More enhanced power sources compatible with extended thermal environment are therefore needed for some space applications like next generation launchers or radar satellites. It is believed that synergy between terrestrial and space sectors could foster the avoidance of multiple financing for the development of similar technologies and systems, as well as dual-use of facilities, providing some real applications for synergy. CEA experienced terrestrial requirements for Hybrid Electric Vehicle applications, start & stop, e-buses and other larger vehicles. In this frame, materials especially designed for high power needs, new cells conception and recently hybrid supercapacitors developments at CEA are discussed as potential solutions for space high power feature.

America in Space: The First Decade - Spacecraft Power

NASA Technical Reports Server (NTRS)

Corliss, William R.

1970-01-01

Electrical power is necessary for every manned and unmanned spacecraft, with the exception of a few special-purpose Earth satellites. It is the reliable flow and availability of electrical power that allows man to extend his personal ventures safely beyond the atmosphere and keeps unmanned scientific payloads serving as useful tools for space exploration and applications. Electric power is essential to space communications, guidance, control, tracking, telemetry, life-support systems, sensors, data handling and storage, and to assure the proper functioning of countless experimental and housekeeping systems and subsystems aboard operating spacecraft. It remains the task of the National Aeronautics and Space Administration, since NASA's founding in 1958, to fully investigate the chemical, nuclear and solar sources of energy and to see how best they can be converted to reliable spacecraft power. The research and technology of power-generating systems illustrates a seldom recognized goal of NASA - to assure this Nation a freedom of choice; the choice, in this case, being that of going where we wish to go in the atmosphere or in space. Technical capability is the key to such freedom. Power requirements and profiles are reviewed and power sources, including batteries, fuel cells, solar cell, RTGs and nuclear fission power plants in space, are highlighted.

Millimeterwave Space Power Grid architecture development 2012

NASA Astrophysics Data System (ADS)

Komerath, Narayanan; Dessanti, Brendan; Shah, Shaan

This is an update of the Space Power Grid architecture for space-based solar power with an improved design of the collector/converter link, the primary heater and the radiator of the active thermal control system. The Space Power Grid offers an evolutionary approach towards TeraWatt-level Space-based solar power. The use of millimeter wave frequencies (around 220GHz) and Low-Mid Earth Orbits shrinks the size of the space and ground infrastructure to manageable levels. In prior work we showed that using Brayton cycle conversion of solar power allows large economies of scale compared to the linear mass-power relationship of photovoltaic conversion. With high-temperature materials permitting 3600 K temperature in the primary heater, over 80 percent cycle efficiency was shown with a closed helium cycle for the 1GW converter satellite which formed the core element of the architecture. Work done since the last IEEE conference has shown that the use of waveguides incorporated into lighter-than-air antenna platforms, can overcome the difficulties in transmitting millimeter wave power through the moist, dense lower atmosphere. A graphene-based radiator design conservatively meets the mass budget for the waste heat rejection system needed for the compressor inlet temperature. Placing the ultralight Mirasol collectors in lower orbits overcomes the solar beam spot size problem of high-orbit collection. The architecture begins by establishing a power exchange with terrestrial renewable energy plants, creating an early revenue generation approach with low investment. The approach allows for technology development and demonstration of high power millimeter wave technology. A multinational experiment using the International Space Station and another power exchange satellite is proposed to gather required data and experience, thus reducing the technical and policy risks. The full-scale architecture deploys pairs of Mirasol sunlight collectors and Girasol 1 GW converter satellites t- ramp up space solar power level to over 5.6 TeraWatts by year 50 from project start. Runway-based launch and landing are required to achieve the launch productivity as well as the cost reductions to enable such a large deployment on schedule. Advancements in the certainty of millimeter wave conversion technology and runway-based space access, are seen to be the outstanding issues in proceeding to full-scale Space Solar Power.

Development and Utilization of Space Fission Power Systems

NASA Technical Reports Server (NTRS)

Houts, Michael G.; Mason, Lee S.; Palac, Donald T.; Harlow, Scott E.

2009-01-01

Space fission power systems could enable advanced civilian space missions. Terrestrially, thousands of fission systems have been operated since 1942. In addition, the US flew a space fission system in 1965, and the former Soviet Union flew 33 such systems prior to the end of the Cold War. Modern design and development practices, coupled with 65 years of experience with terrestrial reactors, could enable the affordable development of space fission power systems for near-term planetary surface applications.

Development and Utilization of Space Fission Power Systems

NASA Technical Reports Server (NTRS)

Houts, Michael; Mason, Lee S.; Palac, Donald T.; Harlow, Scott E.

2008-01-01

Space fission power systems could enable advanced civilian space missions. Terrestrially, thousands of fission systems have been operated since 1942. In addition, the US flew a space fission system in 1965, and the former Soviet Union flew 33 such systems prior to the end of the Cold War. Modern design and development practices, coupled with 65 years of experience with terrestrial reactors, could enable the affordable development of space fission power systems for near-term planetary surface applications.

Potential converter for laser-power beaming

NASA Technical Reports Server (NTRS)

Walker, Gilbert H.; Williams, Michael D.; Schuster, Gregory L.; Iles, Peter A.

1991-01-01

Future space missions, such as those associated with the Space Exploration Initiative (SEI), will require large amounts of power for operation of bases, rovers, and orbit transfer vehicles. One method for supplying this power is to beam power from a spaced based or Earth based laser power station to a receiver where laser photons can be converted to electricity. Previous research has described such laser power stations orbiting the Moon and beaming power to a receiver on the surface of the Moon by using arrays of diode lasers. Photovoltaic converters that can be efficiently used with these diode lasers are described.

A role for high frequency superconducting devices in free space power transmission systems

NASA Technical Reports Server (NTRS)

Christian, Jose L., Jr.; Cull, Ronald C.

1988-01-01

Major advances in space power technology are being made in photovoltaic, solar thermal, and nuclear systems. Despite these advances, the power systems required by the energy and power intensive mission of the future will be massive due to the large collecting surfaces, large thermal management systems, and heavy shielding. Reducing this mass on board the space vehicle can result in significant benefits because of the high cost of transporting and moving mass about in space. An approach to this problem is beaming the power from a point where the massiveness of the power plant is not such a major concern. The viability of such an approach was already investigated. Efficient microwave power beam transmission at 2.45 GHz was demonstrated over short range. Higher frequencies are desired for efficient transmission over several hundred or thousand kilometers in space. Superconducting DC-RF conversion as well as RF-DC conversion offers exciting possibilities. Multivoltage power conditioning for multicavity high power RF tubes could be eliminated since only low voltages are required for Josephson junctions. Small, high efficiency receivers may be possible using the reverse Josephson effects. A conceptual receiving antenna design using superconducting devices to determine possible system operating efficiency is assessed. If realized, these preliminary assessments indicate a role for superconducting devices in millimeter and submillimeter free space power transmission systems.

Mahan for the Twenty First Century: His Principles Still Apply to National Power

DTIC Science & Technology

2003-01-01

adherence to his principles. Mahan was not able to envision air power, space power, or information dominance as critical elements of national power...But he was an astute scholar, and the principles that he outlined as requirements for sea power are still relevant today to air power, space power, and information dominance .

Emerging US Space Launch, Trends and Space Solar Power

NASA Technical Reports Server (NTRS)

Zapata, Edgar

2015-01-01

Reviews the state of the art of emerging US space launch and spacecraft. Reviews the NASA budget ascontext, while providing example scenarios. Connects what has been learned in space systems commercial partnershipsto a potential path for consideration by the space solar power community.

NASA Office of Aeronautics and Space Technology Summer Workshop. Volume 4: Power technology panel

NASA Technical Reports Server (NTRS)

1975-01-01

Technology requirements in the areas of energy sources and conversion, power processing, distribution, conversion, and transmission, and energy storage are identified for space shuttle payloads. It is concluded that the power system technology currently available is adequate to accomplish all missions in the 1973 Mission Model, but that further development is needed to support space opportunities of the future as identified by users. Space experiments are proposed in the following areas: power generation in space, advanced photovoltaic energy converters, solar and nuclear thermoelectric technology, nickel-cadmium batteries, flywheels (mechanical storage), satellite-to-ground transmission and reconversion systems, and regenerative fuel cells.

State-of-the art of dc components for secondary power distribution of Space Station Freedom

NASA Technical Reports Server (NTRS)

Krauthamer, Stanley; Gangal, Mukund; Das, Radhe S. L.

1991-01-01

120-V dc secondary power distribution has been selected for Space Station Freedom. State-of-the art components and subsystems are examined in terms of performance, size, and topology. One of the objectives of this work is to inform Space Station users what is available in power supplies and power control devices. The other objective is to stimulate interest in the component industry so that more focused product development can be started. Based on results of this study, it is estimated that, with some redesign, modifications, and space qualification, may of these components may be applied to Space Station needs.

Key issues in space nuclear power challenges for the future

NASA Technical Reports Server (NTRS)

Brandhorst, Henry W., Jr.

1991-01-01

The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. Key to the success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience has been made. These needs fall into three broad categories: survival, self sufficiency, and industrialization. The cost of delivering payloads to orbital locations from LEO to Mars has been determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options has been made. These goals are largely dependent upon orbital location and energy storage needs. Finally the cost of present space power systems has been determined and projections made for future systems.

Key issues in space nuclear power

NASA Technical Reports Server (NTRS)

Brandhorst, Henry W.

1991-01-01

The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. Key to the success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience has been made. These needs fall into three broad categories: survival, self sufficiency, and industrialization. The cost of delivering payloads to orbital locations from LEO to Mars has been determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options has been made. These goals are largely dependent upon orbital location and energy storage needs. Finally the cost of present space power systems has been determined and projections made for future systems.

Progress in space nuclear reactor power systems technology development - The SP-100 program

NASA Technical Reports Server (NTRS)

Davis, H. S.

1984-01-01

Activities related to the development of high-temperature compact nuclear reactors for space applications had reached a comparatively high level in the U.S. during the mid-1950s and 1960s, although only one U.S. nuclear reactor-powered spacecraft was actually launched. After 1973, very little effort was devoted to space nuclear reactor and propulsion systems. In February 1983, significant activities toward the development of the technology for space nuclear reactor power systems were resumed with the SP-100 Program. Specific SP-100 Program objectives are partly related to the determination of the potential performance limits for space nuclear power systems in 100-kWe and 1- to 100-MW electrical classes. Attention is given to potential missions and applications, regimes of possible space power applicability, safety considerations, conceptual system designs, the establishment of technical feasibility, nuclear technology, materials technology, and prospects for the future.

Overview of Energy Storage Technologies for Space Applications

NASA Technical Reports Server (NTRS)

Surampudi, Subbarao

2006-01-01

This presentations gives an overview of the energy storage technologies that are being used in space applications. Energy storage systems have been used in 99% of the robotic and human space missions launched since 1960. Energy storage is used in space missions to provide primary electrical power to launch vehicles, crew exploration vehicles, planetary probes, and astronaut equipment; store electrical energy in solar powered orbital and surface missions and provide electrical energy during eclipse periods; and, to meet peak power demands in nuclear powered rovers, landers, and planetary orbiters. The power source service life (discharge hours) dictates the choice of energy storage technology (capacitors, primary batteries, rechargeable batteries, fuel cells, regenerative fuel cells, flywheels). NASA is planning a number of robotic and human space exploration missions for the exploration of space. These missions will require energy storage devices with mass and volume efficiency, long life capability, an the ability to operate safely in extreme environments. Advanced energy storage technologies continue to be developed to meet future space mission needs.

Technical Guidance from the International Safety Framework for Nuclear Power Source Applications in Outer Space for Design and Development Phases

NASA Astrophysics Data System (ADS)

Summerer, Leopold

2014-08-01

In 2009, the International Safety Framework for Nuclear Power Source Applications in Outer Space [1] has been adopted, following a multi-year process that involved all major space faring nations in the frame of the International Atomic Energy Agency and the UN Committee on the Peaceful Uses of Outer Space. The safety framework reflects an international consensus on best practices. After the older 1992 Principles Relevant to the Use of Nuclear Power Sources in Outer Space, it is the second document at UN level dedicated entirely to space nuclear power sources.This paper analyses aspects of the safety framework relevant for the design and development phases of space nuclear power sources. While early publications have started analysing the legal aspects of the safety framework, its technical guidance has not yet been subject to scholarly articles. The present paper therefore focuses on the technical guidance provided in the safety framework, in an attempt to assist engineers and practitioners to benefit from these.

Status of the NASA Stirling Radioisotope Project

NASA Technical Reports Server (NTRS)

Schreiber, Jeffrey G.

2007-01-01

Free-piston Stirling power conversion has been considered a candidate for radioisotope power systems for space for more than a decade. Prior to the free-piston Stirling architecture, systems were designed with kinematic Stirling engines that used linkages and rotary alternators to convert heat to electricity. These systems were able to achieve long life by lightly loading the linkages; however, the live was nonetheless limited. When the free-piston configuration was initially proposed, it was thought to be attractive due to the relatively high conversion efficiency, acceptable mass, and the potential for long life and high reliability based on wear-free operation. These features have consistently been recognized by teams that have studied technology options for radioisotope space power systems. Since free-piston Stirling power conversion was first considered for space power applications, there have been major advances in three general areas of development: hardware that has demonstrated long-life and reliability, the success achieved by Stirling cryocoolers in space, and the overall developmental maturity of the technology for both space and terrestrial applications. Based on these advances, free-piston Stirling convertors are currently being developed for space power, and for a number of terrestrial applications. They commonly operate with the power, efficiency, life, and reliability as intended, and much of the development now centers on system integration. This paper will summarize the accomplishments of free-piston Stirling power conversion technology over the past decade, review the status of development with regard to space power, and discuss the challenges that remain.

Comprehensive Software Simulation on Ground Power Supply for Launch Pads and Processing Facilities at NASA Kennedy Space Center

NASA Technical Reports Server (NTRS)

Dominguez, Jesus A.; Victor, Elias; Vasquez, Angel L.; Urbina, Alfredo R.

2017-01-01

A multi-threaded software application has been developed in-house by the Ground Special Power (GSP) team at NASA Kennedy Space Center (KSC) to separately simulate and fully emulate all units that supply VDC power and battery-based power backup to multiple KSC launch ground support systems for NASA Space Launch Systems (SLS) rocket.

Energy loss analysis of an integrated space power distribution system

NASA Technical Reports Server (NTRS)

Kankam, M. D.; Ribeiro, P. F.

1992-01-01

The results of studies related to conceptual topologies of an integrated utility-like space power system are described. The system topologies are comparatively analyzed by considering their transmission energy losses as functions of mainly distribution voltage level and load composition. The analysis is expedited by use of a Distribution System Analysis and Simulation (DSAS) software. This recently developed computer program by the Electric Power Research Institute (EPRI) uses improved load models to solve the power flow within the system. However, present shortcomings of the software with regard to space applications, and incompletely defined characteristics of a space power system make the results applicable to only the fundamental trends of energy losses of the topologies studied. Accountability, such as included, for the effects of the various parameters on the system performance can constitute part of a planning tool for a space power distribution system.

International Space Station Electric Power System Performance Code-SPACE

NASA Technical Reports Server (NTRS)

Hojnicki, Jeffrey; McKissock, David; Fincannon, James; Green, Robert; Kerslake, Thomas; Delleur, Ann; Follo, Jeffrey; Trudell, Jeffrey; Hoffman, David J.; Jannette, Anthony;

Development of an automated electrical power subsystem testbed for large spacecraft

NASA Technical Reports Server (NTRS)

Hall, David K.; Lollar, Louis F.

1990-01-01

The NASA Marshall Space Flight Center (MSFC) has developed two autonomous electrical power system breadboards. The first breadboard, the autonomously managed power system (AMPS), is a two power channel system featuring energy generation and storage and 24-kW of switchable loads, all under computer control. The second breadboard, the space station module/power management and distribution (SSM/PMAD) testbed, is a two-bus 120-Vdc model of the Space Station power subsystem featuring smart switchgear and multiple knowledge-based control systems. NASA/MSFC is combining these two breadboards to form a complete autonomous source-to-load power system called the large autonomous spacecraft electrical power system (LASEPS). LASEPS is a high-power, intelligent, physical electrical power system testbed which can be used to derive and test new power system control techniques, new power switching components, and new energy storage elements in a more accurate and realistic fashion. LASEPS has the potential to be interfaced with other spacecraft subsystem breadboards in order to simulate an entire space vehicle. The two individual systems, the combined systems (hardware and software), and the current and future uses of LASEPS are described.

Performance analysis of radiation cooled dc transmission lines for high power space systems

NASA Technical Reports Server (NTRS)

Schwarze, G. E.

1985-01-01

As space power levels increase to meet mission objectives and also as the transmission distance between power source and load increases, the mass, volume, power loss, and operating voltage and temperature become important system design considerations. This analysis develops the dependence of the specific mass and percent power loss on hte power and voltage levels, transmission distance, operating temperature and conductor material properties. Only radiation cooling is considered since the transmission line is assumed to operate in a space environment. The results show that the limiting conditions for achieving low specific mass, percent power loss, and volume for a space-type dc transmission line are the permissible transmission voltage and operating temperature. Other means to achieve low specific mass include the judicious choice of conductor materials. The results of this analysis should be immediately applicable to power system trade-off studies including comparisons with ac transmission systems.

The International Safety Framework for nuclear power source applications in outer space-Useful and substantial guidance

NASA Astrophysics Data System (ADS)

Summerer, L.; Wilcox, R. E.; Bechtel, R.; Harbison, S.

2015-06-01

In 2009, the International Safety Framework for Nuclear Power Source Applications in Outer Space was adopted, following a multi-year process that involved all major space faring nations under the auspices of a partnership between the UN Committee on the Peaceful Uses of Outer Space and the International Atomic Energy Agency. The Safety Framework reflects an international consensus on best practices to achieve safety. Following the 1992 UN Principles Relevant to the Use of Nuclear Power Sources in Outer Space, it is the second attempt by the international community to draft guidance promoting the safety of applications of nuclear power sources in space missions. NPS applications in space have unique safety considerations compared with terrestrial applications. Mission launch and outer space operational requirements impose size, mass and other space environment limitations not present for many terrestrial nuclear facilities. Potential accident conditions could expose nuclear power sources to extreme physical conditions. The Safety Framework is structured to provide guidance for both the programmatic and technical aspects of safety. In addition to sections containing specific guidance for governments and for management, it contains technical guidance pertinent to the design, development and all mission phases of space NPS applications. All sections of the Safety Framework contain elements directly relevant to engineers and space mission designers for missions involving space nuclear power sources. The challenge for organisations and engineers involved in the design and development processes of space nuclear power sources and applications is to implement the guidance provided in the Safety Framework by integrating it into the existing standard space mission infrastructure of design, development and operational requirements, practices and processes. This adds complexity to the standard space mission and launch approval processes. The Safety Framework is deliberately generic to remain relevantly independent of technological progress, of national organisational setups and of space mission types. Implementing its guidance therefore leaves room for interpretation and adaptation. Relying on reported practices, we analyse the guidance particularly relevant to engineers and space mission designers.

Market Driven Space Exploration

NASA Astrophysics Data System (ADS)

Gavert, Raymond B.

2004-02-01

Market driven space exploration will have the opportunity to develop to new levels with the coming of space nuclear power and propulsion. NASA's recently established Prometheus program is expected to receive several billion dollars over the next five years for developing nuclear power and propulsion systems for future spacecraft. Not only is nuclear power and propulsion essential for long distance Jupiter type missions, but it also important for providing greater access to planets and bodies nearer to the Earth. NASA has been working with industrial partners since 1987 through its Research Partnerships Centers (RPCs) to utilize the attributes of space in Low Earth Orbit (LEO). Plans are now being made to utilize the RPCs and industrial partners in extending the duration and boundaries of human space flight to create new opportunities for exploration and discovery. Private investors are considering setting up shops in LEO for commercial purposes. The trend is for more industrial involvement in space. Nuclear power and propulsion will hasten the progress. The objective of this paper is to show the progression of space market driven research and its potential for supporting space exploration given nuclear power and propulsion capabilities.

Kilopower: Small and Affordable Fission Power Systems for Space

NASA Technical Reports Server (NTRS)

Mason, Lee; Palac, Don; Gibson, Marc

2017-01-01

The Nuclear Systems Kilopower Project was initiated by NASA's Space Technology Mission Directorate Game Changing Development Program in fiscal year 2015 to demonstrate subsystem-level technology readiness of small space fission power in a relevant environment (Technology Readiness Level 5) for space science and human exploration power needs. The Nuclear Systems Kilopower Project centerpiece is the Kilopower Reactor Using Stirling Technology (KRUSTY) test, which consists of the development and testing of a fission ground technology demonstrator of a 1 kWe-class fission power system. The technologies to be developed and validated by KRUSTY are extensible to space fission power systems from 1 to 10 kWe, which can enable higher power future potential deep space science missions, as well as modular surface fission power systems for exploration. The Kilopower Project is cofounded by NASA and the Department of Energy National Nuclear Security Administration (NNSA).KRUSTY include the reactor core, heat pipes to transfer the heat from the core to the power conversion system, and the power conversion system. Los Alamos National Laboratory leads the design of the reactor, and the Y-12 National Security Complex is fabricating it. NASA Glenn Research Center (GRC) has designed, built, and demonstrated the balance of plant heat transfer and power conversion portions of the KRUSTY experiment. NASA MSFC developed an electrical reactor simulator for non-nuclear testing, and the design of the reflector and shielding for nuclear testing. In 2016, an electrically heated non-fissionable Depleted Uranium (DU) core was tested at GRC in a configuration identical to the planned nuclear test. Once the reactor core has been fabricated and shipped to the Device Assembly Facility at the NNSAs Nevada National Security Site, the KRUSTY nuclear experiment will be assembled and tested. Completion of the KRUSTY experiment will validate the readiness of 1 to 10 kWe space fission technology for NASAs future requirements for sunlight-independent space power. An early opportunity for demonstration of In-Situ Resource Utilization (ISRU) capability on the surface of Mars is currently being considered for 2026 launch. Since a space fission system is the leading option for power generation for the first Mars human outpost, a smaller version of a planetary surface fission power system could be built to power the ISRU demonstration and ensure its end-to-end validity. Planning is underway to start the hardware development of this subscale flight demonstrator in 2018.

Dioptric power: its nature and its representation in three- and four-dimensional space.

PubMed

Harris, W F

1997-06-01

Dioptric power expressed in the familiar three-component form of sphere, cylinder, and axis is unsuited to mathematical and statistical treatments; there is a particular class of power that cannot be represented in the familiar form; and it is possible that sphere, cylinder, and axis will prove inadequate in future clinical and research applications in optometry and ophthalmology. Dioptric power expressed as the four-component dioptric power matrix, however, overcomes these shortcomings. The intention in this paper is to provide a definitive statement on the nature, function, and mathematical representation of dioptric power in terms of the matrix and within the limitations of paraxial or linear optics. The approach is universal in the sense that its point of departure is not power of the familiar form (that is, of thin systems) but of systems in general (thick or thin). Familiar types of power are then seen within the context of power in general. Dioptric power is defined, for systems that may be thick and astigmatic, in terms of the ray transfer matrix. A functional definition is presented for dioptric power and its components: it defines the additive contribution of incident position to emergent direction of a ray passing through the system. For systems that are thin (or thin-equivalent) it becomes possible to describe an alternative and more familiar function; for such systems dioptric power can be regarded as the increase in reduced surface curvature of a wavefront brought about by the system as the wavefront passes through it. The curvital and torsional components of the power are explored in some detail. Dioptric power, at its most general, defines a four-dimensional inner product space called dioptric power space. The familiar types of power define a three-dimensional subspace called symmetric dioptric power space. For completeness a one-dimensional antisymmetric power space is also defined: it is orthogonal in four dimensions to symmetric dioptric power space. Various bases are defined for the spaces as are coordinate vectors with respect to them. Vectorial representations of power in the literature apply only to thin systems and are not obviously generalizable to systems in general. They are shown to be merely different coordinate representations of the same subspace, the space of symmetric powers. Some of the uses and disadvantages of the different representations are described. None of the coordinate vectors fully represent, by themselves, the essential character of dioptric power. Their use is limited to applications, such as finding a mean, where addition and scalar multiplication are involved. The full character of power is represented by the dioptric power matrix; it is in this form that power is appropriate for all mathematical relationships.

The space station power system

NASA Technical Reports Server (NTRS)

1989-01-01

The requirements for electrical power by the proposed Space Station Freedom are discussed. The options currently under consideration are examined. The three power options are photovoltaic, solar dynamic, and a hybrid system. Advantages and disadvantages of each system are tabulated. Drawings and artist concepts of the Space Station configuration are provided.

Historical perspectives - The role of the NASA Lewis Research Center in the national space nuclear power programs

NASA Technical Reports Server (NTRS)

Bloomfield, H. S.; Sovie, R. J.

1991-01-01

The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many natural space nuclear power and propulsion programs.

Historical perspectives: The role of the NASA Lewis Research Center in the national space nuclear power programs

NASA Technical Reports Server (NTRS)

Bloomfield, H. S.; Sovie, R. J.

1991-01-01

The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many national space nuclear power and propulsion programs.

Adaptive Power Control for Space Communications

NASA Technical Reports Server (NTRS)

Thompson, Willie L., II; Israel, David J.

2008-01-01

This paper investigates the implementation of power control techniques for crosslinks communications during a rendezvous scenario of the Crew Exploration Vehicle (CEV) and the Lunar Surface Access Module (LSAM). During the rendezvous, NASA requires that the CEV supports two communication links: space-to-ground and crosslink simultaneously. The crosslink will generate excess interference to the space-to-ground link as the distances between the two vehicles decreases, if the output power is fixed and optimized for the worst-case link analysis at the maximum distance range. As a result, power control is required to maintain the optimal power level for the crosslink without interfering with the space-to-ground link. A proof-of-concept will be described and implemented with Goddard Space Flight Center (GSFC) Communications, Standard, and Technology Lab (CSTL).

New directions for space solar power

NASA Astrophysics Data System (ADS)

Mankins, John C.

2009-07-01

Several of the central issues associated with the eventual realization of the vision of solar power from space for terrestrial markets resolve around the expect costs associated with the assembly, inspection, maintenance and repair of future solar power satellite (SPS) stations. In past studies (for example, NASA's "Fresh Look Study", c. 1995-1997) efforts were made to reduce both the scale and mass of large, systems-level interfaces (e.g., the power management and distribution (PMAD) system) and on-orbit fixed infrastructures through the use of modular systems strategies. These efforts have had mixed success (as reflected in the projected on-orbit mass of various systems concepts. However, the author remains convinced of the importance of modular strategies for exceptionally large space systems in eventually realizing the vision of power from space. This paper will introduce some of the key issues associated with cost-competitive space solar power in terrestrial markets. It will examine some of the relevant SPS concepts and will assess the 'pros and cons' of each in terms of space assembly, maintenance and servicing (SAMS) requirements. The paper discusses at a high level some relevant concepts and technologies that may play r role in the eventual, successful resolution of these challenges. The paper concludes with an example of the kind of novel architectural approach for space solar power that is needed.

Wireless Power Transmission Options for Space Solar Power

NASA Technical Reports Server (NTRS)

Henley, Mark; Potter, Seth; Howell, Joseph; Mankins, John

2002-01-01

Space Solar Power (SSP), combined with Wireless Power Transmission (WPT), offers the far-term potential to solve major energy problems on Earth. In this paper two basic WPT options, using radio waves and light waves, are considered for both long-term and near-term SSP applications. In the long-term, we aspire to beam energy to Earth from geostationary Earth orbit (GEO), or even further distances in space. Accordingly, radio- and light- wave WPT options are compared through a wide range of criteria, each showing certain strengths. In the near-term, we plan to beam power over more moderate distances, but still stretch the limits of today's technology. For the near-term, a 100 kWe-class 'Power Plug' Satellite and a 10 kWe-class Lunar Polar Solar Power outpost are considered as the first steps in using these WPT options for SSP. By using SSP and WPT technology in near-term space science and exploration missions, we gain experience needed for sound decisions in designing and developing larger systems to send power from Space to Earth.

Wireless Power Transmission Options for Space Solar Power

NASA Technical Reports Server (NTRS)

Henley, Mark; Potter, Seth; Howell, Joseph; Mankins, John

2007-01-01

Space Solar Power (SSP), combined with Wireless Power Transmission (WPT), offers the far-term potential to solve major energy problems on Earth. In this presentation, two basic WPT options, using radio waves an d light waves, are considered for both long-term and near-term SSP applications. In the long-term, we aspire to beam energy to Earth from geostationary Earth orbit (GEO), or even further distances in space. Accordingly, radio- and light- wave WPT options are compared through a wide range of criteria, each showing certain strengths. In the near-term, we plan to beam power over more moderate distances, but still stretch the limits of today's technology. For the near-term, a 100 kWe-class "Power Plug" Satellite and a 10 kWe-class Lunar Polar Solar Power outpost are considered as the first steps in using these WPT options for SSP. By using SSP and WPT technology in nearterm space science and exploration missions, we gain experience needed for sound decisions in designing and developing larger systems to send power from Space to Earth.

Reinventing the Solar Power Satellite

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.

2002-01-01

Economy of scale is inherent in the microwave power transmission aperture/spot-size trade-off, resulting in a requirement for large space systems in the existing design concepts. Unfortunately, this large size means that the initial investment required before the first return, and the price of amortization of this initial investment, is a daunting (and perhaps insurmountable) barrier to economic viability. As the growth of ground-based solar power applications will fund the development of the PV technology required for space solar power and will also create the demand for space solar power by manufacturing a ready-made market, space power systems must be designed with an understanding that ground-based solar technologies will be implemented as a precursor to space-based solar. for low initial cost, (3) operation in synergy with ground solar systems, and (4) power production profile tailored to peak rates. A key to simplicity of design is to maximize the integration of the system components. Microwave, millimeter-wave, and laser systems are analyzed. A new solar power satellite design concept with no sun-tracking and no moving parts is proposed to reduce the required cost to initial operational capability.

NASA Capabilities That Could Impact Terrestrial Smart Grids of the Future

NASA Technical Reports Server (NTRS)

Beach, Raymond F.

2015-01-01

Incremental steps to steadily build, test, refine, and qualify capabilities that lead to affordable flight elements and a deep space capability. Potential Deep Space Vehicle Power system characteristics: power 10 kilowatts average; two independent power channels with multi-level cross-strapping; solar array power 24 plus kilowatts; multi-junction arrays; lithium Ion battery storage 200 plus ampere-hours; sized for deep space or low lunar orbit operation; distribution120 volts secondary (SAE AS 5698); 2 kilowatt power transfer between vehicles.

Design investigation of solar powered lasers for space applications

NASA Technical Reports Server (NTRS)

Taussig, R.; Bruzzone, C.; Quimby, D.; Nelson, L.; Christiansen, W.; Neice, S.; Cassady, P.; Pindroh, A.

1979-01-01

The feasibility of solar powered lasers for continuous operation in space power transmission was investigated. Laser power transmission in space over distances of 10 to 100 thousand kilometers appears possible. A variety of lasers was considered, including solar-powered GDLs and EDLs, and solar-pumped lasers. An indirect solar-pumped laser was investigated which uses a solar-heated black body cavity to pump the lasant. Efficiencies in the range of 10 to 20 percent are projected for these indirect optically pumped lasers.

Space transportation alternatives for large space programs - The International Space University summer session - 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

1993-01-01

The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group at the International Space University (ISU) summer session of 1992 to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed.

Bacterial Fission, Powers of Two, Sociology, Environmental Science, Public Health, Biology, Mathematics: An Integration of Constructivism, Discovery, and Inquiry

ERIC Educational Resources Information Center

Schlenker, Richard; Tierney, Kathleen

2006-01-01

Students examine the bacterial expansion pattern and attempt to relate what they discover to expanding powers of two. They also relate what they see and discover to increasing living space requirements in a world of infinite space and finite space to discover that living space decreases as a function of one over expanding powers of two. The…

Lewis Research Center space station electric power system test facilities

NASA Technical Reports Server (NTRS)

Birchenough, Arthur G.; Martin, Donald F.

1988-01-01

NASA Lewis Research Center facilities were developed to support testing of the Space Station Electric Power System. The capabilities and plans for these facilities are described. The three facilities which are required in the Phase C/D testing, the Power Systems Facility, the Space Power Facility, and the EPS Simulation Lab, are described in detail. The responsibilities of NASA Lewis and outside groups in conducting tests are also discussed.

Space-to-Space Power Beaming Enabling High Performance Rapid Geocentric Orbit Transfer

NASA Technical Reports Server (NTRS)

Dankanich, John W.; Vassallo, Corinne; Tadge, Megan

2015-01-01

The use of electric propulsion is more prevalent than ever, with industry pursuing all electric orbit transfers. Electric propulsion provides high mass utilization through efficient propellant transfer. However, the transfer times become detrimental as the delta V transitions from near-impulsive to low-thrust. Increasing power and therefore thrust has diminishing returns as the increasing mass of the power system limits the potential acceleration of the spacecraft. By using space-to-space power beaming, the power system can be decoupled from the spacecraft and allow significantly higher spacecraft alpha (W/kg) and therefore enable significantly higher accelerations while maintaining high performance. This project assesses the efficacy of space-to-space power beaming to enable rapid orbit transfer while maintaining high mass utilization. Concept assessment requires integrated techniques for low-thrust orbit transfer steering laws, efficient large-scale rectenna systems, and satellite constellation configuration optimization. This project includes the development of an integrated tool with implementation of IPOPT, Q-Law, and power-beaming models. The results highlight the viability of the concept, limits and paths to infusion, and comparison to state-of-the-art capabilities. The results indicate the viability of power beaming for what may be the only approach for achieving the desired transit times with high specific impulse.

Spacecraft Power. America in Space: The First Decade.

ERIC Educational Resources Information Center

Corliss, William R.

The various electric power sources suitable for use aboard spacecraft are described in this booklet. These power sources include batteries, fuel cells, solar cells, RTGs (radioisotope thermoelectric generator), and nuclear fission power plants. The introductory sections include a discussion of power requirements and the anatomy of a space power…

Applicability of 100kWe-class of space reactor power systems to NASA manned space station missions

NASA Technical Reports Server (NTRS)

Silverman, S. W.; Willenberg, H. J.; Robertson, C.

1985-01-01

An assessment is made of a manned space station operating with sufficiently high power demands to require a multihundred kilowatt range electrical power system. The nuclear reactor is a competitor for supplying this power level. Load levels were selected at 150kWe and 300kWe. Interactions among the reactor electrical power system, the manned space station, the space transportation system, and the mission were evaluated. The reactor shield and the conversion equipment were assumed to be in different positions with respect to the station; on board, tethered, and on a free flyer platform. Mission analyses showed that the free flyer concept resulted in unacceptable costs and technical problems. The tethered reactor providing power to an electrolyzer for regenerative fuel cells on the space station, results in a minimum weight shield and can be designed to release the reactor power section so that it moves to a high altitude orbit where the decay period is at least 300 years. Placing the reactor on the station, on a structural boom is an attractive design, but heavier than the long tethered reactor design because of the shield weight for manned activity near the reactor.

A Solar Dynamic Power Option for Space Solar Power

NASA Technical Reports Server (NTRS)

Mason, Lee S.

1999-01-01

A study was performed to determine the potential performance and related technology requirements of Solar Dynamic power systems for a Space Solar Power satellite. Space Solar Power is a concept where solar energy is collected in orbit and beamed to Earth receiving stations to supplement terrestrial electric power service. Solar Dynamic systems offer the benefits of high solar-to-electric efficiency, long life with minimal performance degradation, and high power scalability. System analyses indicate that with moderate component development, SD systems can exhibit excellent mass and deployed area characteristics. Using the analyses as a guide, a technology roadmap was -enerated which identifies the component advances necessary to make SD power generation a competitive option for the SSP mission.

Fusion energy for space: Feasibility demonstration. A proposal to NASA

NASA Technical Reports Server (NTRS)

Schulze, Norman R.

1992-01-01

This proposed program is to initiate a space flight research and development program to develop fusion energy for the space applications of direct space propulsion and direct space power, that is, a Space Fusion Energy (SFE) program. 'Direct propulsion' refers to the use of plasma energy directly for thrust without requiring other energy conversion systems. Further, to provide space missions with large electrical power, 'direct space power' is proposed whereby the direct conversion of charged particles into electricity is used, thereby avoiding thermal conversion system losses. The energy release from nuclear fusion reactions makes these highly efficient, high power space systems possible. The program as presented conducts in an orderly, hierarchical manner the necessary planning, analyses, and testing to demonstrate the practical use of fusion energy for space. There is nothing discussed that is known to be theoretically impossible. Validation of the engineering principles is sought in this program which uses a cost-benefit approach. Upon successful program completion, space will become more accessible and space missions more safely conducted. The country will have taken a giant step toward the commercialization of space. The mission enabling capability provided by fusion energy is well beyond mission planners' current dreams.

Advanced solar dynamic space power systems perspectives, requirements and technology needs

NASA Technical Reports Server (NTRS)

Dustin, M. O.; Savino, J. M.; Lacy, D. E.; Migra, R. P.; Juhasz, A. J.; Coles, C. E.

1986-01-01

Projected NASA, Civil, Commercial, and Military missions will require space power systems of increased versatility and power levels. The Advanced Solar Dynamic (ASD) Power systems offer the potential for efficient, lightweight, survivable, relatively compact, long-lived space power systems applicable to a wide range of power levels (3 to 300 kWe), and a wide variety of orbits. The successful development of these systems could satisfy the power needs for a wide variety of these projected missions. Thus, the NASA Lewis Research Center has embarked upon an aggressive ASD reserach project under the direction of NASA's Office of Aeronautics and Space Technology (DAST). The project is being implemented through a combination of in-house and contracted efforts. Key elements of this project are missions analysis to determine the power systems requirements, systems analysis to identify the most attractive ASD power systems to meet these requirements, and to guide the technology development efforts, and technology development of key components.

Second Beamed Space-Power Workshop

NASA Technical Reports Server (NTRS)

Deyoung, Russell J. (Editor)

1989-01-01

Potential missions for microwave and laser power beaming in space are discussed. Power beaming options, millimeter wave technology, laser technology, lunar bases, spacecraft propulsion, and near-Earth applications are covered.

A microfluidic biochip for complete blood cell counts at the point-of-care

PubMed Central

Hassan, U.; Reddy, B.; Damhorst, G.; Sonoiki, O.; Ghonge, T.; Yang, C.; Bashir, R.

2016-01-01

Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensive hematology analyzers are currently used as a gold standard for acquiring CBCs. For nearly all CBCs performed today, the patient must travel to either a hospital with a large laboratory or to a centralized lab testing facility. There is a tremendous need for an automated, portable point-of-care blood cell counter that could yield results in a matter of minutes from a drop of blood without any trained professionals to operate the instrument. We have developed microfluidic biochips capable of a partial CBC using only a drop of whole blood. Total leukocyte and their 3-part differential count are obtained from 10 μL of blood after on-chip lysing of the RBCs and counting of the leukocytes electrically using microfabricated platinum electrodes. For RBCs and platelets, 1 μL of whole blood is diluted with PBS on-chip and the cells are counted electrically. The total time for measurement is under 20 minutes. We demonstrate a high correlation of blood cell counts compared to results acquired with a commercial hematology analyzer. This technology could potentially have tremendous applications in hospitals at the bedside, private clinics, retail clinics and the developing world. PMID:26909365

A microfluidic biochip for complete blood cell counts at the point-of-care.

PubMed

Hassan, U; Reddy, B; Damhorst, G; Sonoiki, O; Ghonge, T; Yang, C; Bashir, R

2015-12-01

Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensive hematology analyzers are currently used as a gold standard for acquiring CBCs. For nearly all CBCs performed today, the patient must travel to either a hospital with a large laboratory or to a centralized lab testing facility. There is a tremendous need for an automated, portable point-of-care blood cell counter that could yield results in a matter of minutes from a drop of blood without any trained professionals to operate the instrument. We have developed microfluidic biochips capable of a partial CBC using only a drop of whole blood. Total leukocyte and their 3-part differential count are obtained from 10 μL of blood after on-chip lysing of the RBCs and counting of the leukocytes electrically using microfabricated platinum electrodes. For RBCs and platelets, 1 μL of whole blood is diluted with PBS on-chip and the cells are counted electrically. The total time for measurement is under 20 minutes. We demonstrate a high correlation of blood cell counts compared to results acquired with a commercial hematology analyzer. This technology could potentially have tremendous applications in hospitals at the bedside, private clinics, retail clinics and the developing world.

Suspected myelodysplastic/myeloproliferative neoplasm in a feline leukemia virus-negative cat.

PubMed

Weeden, Amy L; Taylor, Kyle R; Terrell, Scott P; Gallagher, Alexander E; Wamsley, Heather L

2016-12-01

A 10-year-old castrated Domestic Short-Haired cat was presented to a primary care veterinarian for a wellness examination and laboratory examination for monitoring of diabetes mellitus. The CBC revealed marked thrombocytosis, leukopenia and macrocytic, normochromic anemia. The cat tested negative for FeLV and feline immunodeficiency virus, but was positive for Mycoplasma haemominutum by PCR. Hematologic abnormalities were not responsive to therapy, so a repeat CBC and a bone marrow aspiration for cytology were performed. Additional blood smear findings included anisocytosis with megaloblastic erythroid precursors, large platelets, eosinophilic myelocytes and metamyelocytes, and rare unidentified blasts. The bone marrow smear was highly cellular, and the cytologic pattern was consistent with myelodysplastic syndrome with an erythroid predominance. At that time, 15% blasts were present. The cat was treated with a vitamin K 2 analog, doxycycline, and prednisolone, but without a clinical response. Within 3 months, euthanasia was elected due to declining quality of life, and a necropsy was performed. Postmortem bone marrow smears were highly cellular and dominated by monomorphic blasts of unknown line of origin (52%), persistent marked erythroid and megakaryocytic dysplasia, and ineffective erythropoiesis and granulopoiesis. Immunohistochemical, immunocytochemical, and cytochemical stains resulted in a diagnosis of acute myeloid leukemia of unclassified type. Additional histologic findings included mixed hepatitis with trematode infestation and lymphoplasmacytic interstitial nephritis with fibrosis. The marked thrombocytosis with myelodysplastic syndrome and the FeLV-negative status of this cat were unusual. The difficulty in classifying the myelodysplasia and subsequent leukemia highlights a need for further reporting and characterization of these types of disease. © 2016 American Society for Veterinary Clinical Pathology.

Obesity is associated with more activated neutrophils in African American male youth.

PubMed

Xu, X; Su, S; Wang, X; Barnes, V; De Miguel, C; Ownby, D; Pollock, J; Snieder, H; Chen, W; Wang, X

2015-01-01

There is emerging evidence suggesting the role of peripheral blood leukocytes in the pathogenesis of obesity and related diseases. However, few studies have taken a genome-wide approach to investigating gene expression profiles in peripheral leukocytes between obese and lean individuals with the consideration of obesity-related shifts in leukocyte types. We conducted this study in 95 African Americans (AAs) of both genders (age 14-20 years, 46 lean and 49 obese). Complete blood count with differential test (CBC) was performed in whole blood. Genome-wide gene expression analysis was obtained using the Illumina HumanHT-12 V4 Beadchip with RNA extracted from peripheral leukocytes. Out of the 95 participants, 64 had neutrophils stored. The validation study was based on real-time PCR with RNA extracted from purified neutrophils. CBC test suggested that, in males, obesity was associated with increased neutrophil percentage (P=0.03). Genome-wide gene expression analysis showed that, in males, the majority of the most differentially expressed genes were related to neutrophil activation. Validation of the gene expression levels of ELANE (neutrophil elastase) and MPO (myeloperoxidase) in purified neutrophils demonstrated that the expression of these two genes--important biomarkers of neutrophils activation--were significantly elevated in obese males (P=0.01 and P=0.02, respectively). The identification of increased neutrophil percentage and activation in obese AA males suggests that neutrophils have an essential role in the pathogenesis of obesity-related disease. Further functional and mechanistic studies on neutrophils may contribute to the development of novel intervention strategies reducing the burden associated with obesity-related health problems.

Specimen rejection in laboratory medicine: Necessary for patient safety?

PubMed Central

Dikmen, Zeliha Gunnur; Pinar, Asli; Akbiyik, Filiz

2015-01-01

Introduction The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the rejection criteria of the laboratory. In this study, we aimed to evaluate the sample rejection ratios according to the types of pre-preanalytical errors and collection areas. Materials and methods The samples sent to the emergency laboratory were recorded during 12 months between January to December, 2013 in which 453,171 samples were received and 27,067 specimens were rejected. Results Rejection ratios was 2.5% for biochemistry tests, 3.2% for complete blood count (CBC), 9.8% for blood gases, 9.2% for urine analysis, 13.3% for coagulation tests, 12.8% for therapeutic drug monitoring, 3.5% for cardiac markers and 12% for hormone tests. The most frequent rejection reasons were fibrin clots (28%) and inadequate volume (9%) for biochemical tests. Clotted samples (35%) and inadequate volume (13%) were the major causes for coagulation tests, blood gas analyses and CBC. The ratio of rejected specimens was higher in the EDs (40%) compared to ICUs (30%) and inpatient services (28%). The highest rejection ratio was observed in neurology ICU (14%) among the ICUs and internal medicine inpatient service (10%) within inpatient clinics. Conclusions We detected an overall specimen rejection rate of 6% in emergency laboratory. By documentation of rejected samples and periodic training of healthcare personnel, we expect to decrease sample rejection ratios below 2%, improve total quality management of the emergency laboratory and promote patient safety. PMID:26527231

Predictions of CD4 lymphocytes’ count in HIV patients from complete blood count

PubMed Central

2013-01-01

Background HIV diagnosis, prognostic and treatment requires T CD4 lymphocytes’ number from flow cytometry, an expensive technique often not available to people in developing countries. The aim of this work is to apply a previous developed methodology that predicts T CD4 lymphocytes’ value based on total white blood cell (WBC) count and lymphocytes count applying sets theory, from information taken from the Complete Blood Count (CBC). Methods Sets theory was used to classify into groups named A, B, C and D the number of leucocytes/mm3, lymphocytes/mm3, and CD4/μL3 subpopulation per flow cytometry of 800 HIV diagnosed patients. Union between sets A and C, and B and D were assessed, and intersection between both unions was described in order to establish the belonging percentage to these sets. Results were classified into eight ranges taken by 1000 leucocytes/mm3, calculating the belonging percentage of each range with respect to the whole sample. Results Intersection (A ∪ C) ∩ (B ∪ D) showed an effectiveness in the prediction of 81.44% for the range between 4000 and 4999 leukocytes, 91.89% for the range between 3000 and 3999, and 100% for the range below 3000. Conclusions Usefulness and clinical applicability of a methodology based on sets theory were confirmed to predict the T CD4 lymphocytes’ value, beginning with WBC and lymphocytes’ count from CBC. This methodology is new, objective, and has lower costs than the flow cytometry which is currently considered as Gold Standard. PMID:24034560

[Prevalence and factors associated with anemia in pregnant women attending the General Hospital in Douala].

PubMed

Tchente, Charlotte Nguefack; Tsakeu, Eveline Ngouadjeu Dongho; Nguea, Arlette Géraldine; Njamen, Théophile Nana; Ekane, Gregory Halle; Priso, Eugene Belley

2016-01-01

Anemia is a public health problem, prevalent among children and women of childbearing age. Our study aims to determine the prevalence and factors associated with anemia in pregnant women at Douala General Hospital. We conducted a cross sectional study from July 2012 to July 2013. All consenting pregnant women attending antenatal consultation and having undergone complete blood count (CBC) were included in the study. Sociodemographic characteristics, individual's obstetrical history and the results of the CBC were recorded on a pre tested data collection sheet. Anemia was defined according to the WHO criteria. After some descriptive statistics, we performed a bivariate analysis using the Chi-square test and Fisher exact probability test in order to determine the factors associated with anemia. P value <0.05 was considered significant. A total of 415 pregnant women were enrolled in the study. Anemia prevalence was 39,8%. The average age was 29,89±4,835 years. The mean hemoglobin level was 10.93 ± 1.23. Normochromic normocytic anemia (53,3%) was prevalent. Anaemia was severe in 2,4% of cases. Anemia in pregnancy was significantly associated with a personal history of chronic diseases (P = 0.02) and of anemia in a previous pregnancy (P = 0.003). Anemia was more frequently observed during the 3rd trimester (P = 0.04) and breastfeeding played a protective role (P = 0.02). The prevalence of anemia during pregnancy remains high. A better management of chronic diseases in pregnant women and of postpartum follow-up is necessary to treat anemia before a subsequent pregnancy.

Evaluation of two platelet-rich plasma processing methods and two platelet-activation techniques for use in llamas and alpacas.

PubMed

Semevolos, Stacy A; Youngblood, Cori D; Grissom, Stephanie K; Gorman, M Elena; Larson, Maureen K

2016-11-01

OBJECTIVE To evaluate 2 processing methods (commercial kit vs conical tube centrifugation) for preparing platelet rich plasma (PRP) for use in llamas and alpacas. SAMPLES Blood samples (30 mL each) aseptically collected from 6 healthy llamas and 6 healthy alpacas. PROCEDURES PRP was prepared from blood samples by use of a commercial kit and by double-step conical tube centrifugation. A CBC was performed for blood and PRP samples. Platelets in PRP samples were activated by means of a freeze-thaw method with or without 23mM CaCl 2 , and concentrations of platelet-derived growth factor-BB and transforming growth factor-β 1 were measured. Values were compared between processing methods and camelid species. RESULTS Blood CBC values for llamas and alpacas were similar. The commercial kit yielded a significantly greater degree of platelet enrichment (mean increase, 8.5 fold vs 2.8 fold) and WBC enrichment (mean increase, 3.7 fold vs 1.9 fold) than did conical tube centrifugation. Llamas had a significantly greater degree of platelet enrichment than alpacas by either processing method. No difference in WBC enrichment was identified between species. Concentrations of both growth factors were significantly greater in PRP samples obtained by use of the commercial kit versus those obtained by conical tube centrifugation. CONCLUSIONS AND CLINICAL RELEVANCE For blood samples from camelids, the commercial kit yielded a PRP product with a higher platelet and WBC concentration than achieved by conical tube centrifugation. Optimal PRP platelet and WBC concentrations for various applications need to be determined for llamas and alpacas.

Discerning the clinical relevance of biomarkers in early stage breast cancer.

PubMed

Ballinger, Tarah J; Kassem, Nawal; Shen, Fei; Jiang, Guanglong; Smith, Mary Lou; Railey, Elda; Howell, John; White, Carol B; Schneider, Bryan P

2017-07-01

Prior data suggest that breast cancer patients accept significant toxicity for small benefit. It is unclear whether personalized estimations of risk or benefit likelihood that could be provided by biomarkers alter treatment decisions in the curative setting. A choice-based conjoint (CBC) survey was conducted in 417 HER2-negative breast cancer patients who received chemotherapy in the curative setting. The survey presented pairs of treatment choices derived from common taxane- and anthracycline-based regimens, varying in degree of benefit by risk of recurrence and in toxicity profile, including peripheral neuropathy (PN) and congestive heart failure (CHF). Hypothetical biomarkers shifting benefit and toxicity risk were modeled to determine whether this knowledge alters choice. Previously identified biomarkers were evaluated using this model. Based on CBC analysis, a non-anthracycline regimen was the most preferred. Patients with prior PN had a similar preference for a taxane regimen as those who were PN naïve, but more dramatically shifted preference away from taxanes when PN was described as severe/irreversible. When modeled after hypothetical biomarkers, as the likelihood of PN increased, the preference for taxane-containing regimens decreased; similarly, as the likelihood of CHF increased, the preference for anthracycline regimens decreased. When evaluating validated biomarkers for PN and CHF, this knowledge did alter regimen preference. Patients faced with multi-faceted decisions consider personal experience and perceived risk of recurrent disease. Biomarkers providing information on likelihood of toxicity risk do influence treatment choices, and patients may accept reduced benefit when faced with higher risk of toxicity in the curative setting.

Hematology and biochemistry of aging-evidence of "anemia of the elderly" in old dogs.

PubMed

Radakovich, Lauren B; Pannone, Stephen C; Truelove, Matthew P; Olver, Christine S; Santangelo, Kelly S

2017-03-01

Effects of aging on hematologic and biochemical variables are well described in people. Anemia of the elderly is attributed to iron deficiency, anemia of chronic disease, chronic kidney disease, myelodysplasia, or idiopathic causes. Limited studies have examined these variables in aging dogs, but they have typically examined single breeds in research settings. The objective of this study was to identify differences in CBC and biochemistry values between adult and aged dogs of many breeds. Dogs presenting for wellness examinations and minor dental/elective surgeries that were otherwise clinically healthy were retrospectively identified. Dogs were categorized by age: adult (1-7.9 years), senior (8-11.9 years), and geriatric (12+ years). Standard CBC and biochemistry data were collated. Asian breeds, Greyhounds, and dogs with data indicating overt underlying disease were excluded. The Kruskal-Wallis test was used to compare groups with statistical significance set at P ≤ .05. Hematocrit, MCV, and serum iron decreased with age, indicating possible iron-restricted erythropoiesis (IRE), due to iron deficiency or low-grade chronic inflammation. Total proteins, globulins, and platelet counts increased with age while albumin decreased, suggesting low-grade inflammation. Urea was increased in older dogs without a concurrent increase in creatinine, which points toward gastrointestinal bleeding or dehydration. Clinically healthy, aging dogs have changes in laboratory variables that indicate altered physiologies compared to younger adult animals, including evidence of IRE, inflammation, and potential gastrointestinal bleeding, suggesting a similar trend to that of elderly human beings. Future studies will examine markers of iron metabolism and inflammation in aging dogs. © 2017 American Society for Veterinary Clinical Pathology.

Is Fasting for Ramadan Safe in Patients with Mechanical Cardiac Valves?

PubMed

Yildirim, Ersin; Secen, Ozlem; Uku, Okkes; Nail Bilen, Mehmet; Kutlu Karadag, Makbule

2017-03-01

The study aim was to investigate the safety and effects of fasting during Ramadan on the International Normalized Ratio (INR) in patients with mechanical cardiac valves. A total of 105 patients admitted to the authors' hospital between June and October 2015, who had history of prosthetic valve replacement, was investigated. The patients were allocated to two groups: those fasting during Ramadan (n = 42) and those not fasting (n = 63). All patients were examined by a cardiologist, and the clinical findings and complaints for the past three months were evaluated. The INR, complete blood count (CBC) and a basic biochemical panel were monitored for all patients. The mean corpuscular volume (MCV) of the fasting group was significantly higher than that of the non- fasting group (87.59 ± 6.39 (μm3) versus 84.28 ± 6.387 (μm3); p = 0.011). Other CBC parameters and basic biochemical values did not differ significantly different between groups. Neither were significant differences noted in INR values during Ramadan (fasting group 2.87 ± 0.97; non-fasting group 2.73 ± 0.78; p = 0.50) and at routine control one month later (fasting group 3.07 ± 1.55; non-fasting group 2.94 ± 1.03; p = 0.601). No significant differences related to increased rates of hospitalization, valvular dysfunction on echocardiography, thrombus, embolism, bleeding and clinical complaints were identified between the groups. Fasting during Ramadan had no adverse effects on the INR of patients, and appears to be safe for patients with mechanical prosthetic cardiac valves.

Yeast hnRNP-related proteins contribute to the maintenance of telomeres

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee-Soety, Julia Y., E-mail: jlee04@sju.edu; Jones, Jennifer; MacGibeny, Margaret A.

Highlights: Black-Right-Pointing-Pointer Yeast hnRNP-related proteins are able to prevent faster senescence in telomerase-null cells. Black-Right-Pointing-Pointer The conserved RRMs in Npl3 are important for telomere maintenance. Black-Right-Pointing-Pointer Human hnRNP A1 is unable to complement the lack of NPL3 in yeast. Black-Right-Pointing-Pointer Npl3 and Cbc2 may work as telomere capping proteins. -- Abstract: Telomeres protect the ends of linear chromosomes, which if eroded to a critical length can become uncapped and lead to replicative senescence. Telomerase maintains telomere length in some cells, but inappropriate expression facilitates the immortality of cancer cells. Recently, proteins involved in RNA processing and ribosome assembly, such asmore » hnRNP (heterogeneous nuclear ribonucleoprotein) A1, have been found to participate in telomere maintenance in mammals. The Saccharomyces cerevisiae protein Npl3 shares significant amino acid sequence similarities with hnRNP A1. We found that deleting NPL3 accelerated the senescence of telomerase null cells. The highly conserved RNA recognition motifs (RRM) in Npl3 appear to be important for preventing faster senescence. Npl3 preferentially binds telomere sequences in vitro, suggesting that Npl3 may affect telomeres directly. Despite similarities between the two proteins, human hnRNP A1 is unable to complement the lack of Npl3 to rescue accelerated senescence in tlc1 npl3 cells. Deletion of CBC2, which encodes another hnRNP-related protein that associates with Npl3, also accelerates senescence. Potential mechanisms by which hnRNP-related proteins maintain telomeres are discussed.« less