Optimized human platelet lysate as novel basis for a serum-, xeno-, and additive-free corneal endothelial cell and tissue culture.

PubMed

Thieme, Daniel; Reuland, Lynn; Lindl, Toni; Kruse, Friedrich; Fuchsluger, Thomas

2018-02-01

The expansion of donor-derived corneal endothelial cells (ECs) is a promising approach for regenerative therapies in corneal diseases. To achieve the best Good Manufacturing Practice standard the entire cultivation process should be devoid of nonhuman components. However, so far, there is no suitable xeno-free protocol for clinical applications. We therefore introduce a processed variant of a platelet lysate for the use in corneal cell and tissue culture based on a Good Manufacturing Practice-grade thrombocyte concentrate. This processed human platelet lysate (phPL), free of any animal components and of anticoagulants such as heparin with a physiological ionic composition, was used to cultivate corneal ECs in vitro and ex vivo in comparison to standard cultivation with fetal calf serum (FCS). Human donor corneas were cut in quarters while 2 quarters of each cornea were incubated with the respective medium supplement. Three fields of view per quarter were taken into account for the analysis. Evaluation of phPL as a medium supplement in cell culture of immortalized EC showed a superior viability compared with FCS control with reduced cell proliferation. Furthermore, the viability during the expansion of primary cells is significantly (3-fold ±0.5) increased with phPL compared with FCS standard medium. Quartering donor corneas was traumatic for the endothelium and therefore resulted in increased EC loss. Interestingly, however, cultivation of the quartered pieces for 2 weeks in 0.1-mg/ml pHPL in Biochrome I showed a 21 (±10) % EC loss compared with 67 (±12) % EC loss when cultivated in 2% FCS in Biochrome I. The cell culture protocol with pHPL as FCS replacement seems to be superior to the standard FCS protocols with respect to EC survival. It offers a xeno-free and physiological environment for corneal endothelial cells. This alternative cultivation protocol could facilitate the use of EC for human corneal cell therapy. Copyright © 2017 John Wiley & Sons, Ltd.

Effect of intramammary infusion of recombinant bovine GM-CSF and IL-8 on CMT score, somatic cell count, and milk mononuclear cell populations in Holstein cows with Staphylococcus aureus subclinical mastitis.

PubMed

Kiku, Yoshio; Ozawa, Tomomi; Takahashi, Hideyuki; Kushibiki, Shiro; Inumaru, Shigeki; Shingu, Hiroyuki; Nagasawa, Yuya; Watanabe, Atsushi; Hata, Eiji; Hayashi, Tomohito

2017-09-01

The effect of intramammary infusion of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) and interleukin-8 (rbIL-8) on mononuclear cell populations in quarters, somatic cell count (SCC) and the California Mastitis Test (CMT) score were investigated. From the selected cows with naturally occurring Staphylococcus aureus subclinical mastitis, one quarter of each cow were selected for the infusions of rbGM-CSF (400 μg/5 mL/quarter, n = 9), rbIL-8 (1 mg/5 mL/quarter, n = 9), and phosphate-buffered saline (5 mL/quarter, n = 7). The CMT score of both cytokines post infusion temporarily increased between days 0 and 1 and significantly decreased between days 7 and 14 compared to the preinfusion level. The SCC on day 14 after infusions of rbGM-CSF tended to be lower than that of the control group. The percentage of CD14+ cells increased on days 1 and 2 post infusion of rbGM-CSF. The percentage of CD4+ and CD8+ cells also increased on days 2 and 3, suggesting that the infusion of rbGM-CSF enhanced cellular immunity in the mammary gland. In contrast, the percentage of CD14+ cells decreased on days 0.25 and 1 post infusion of rbIL-8. No significant changes in the percentages of CD4+ and CD8+ cells in milk after infusion of rbIL-8 were evident during the experimental period, which suggested that rbIL-8 had little effect on the function of T cells in the mammary gland. These results indicated that rbGM-CSF and rbIL-8 decreased the CMT score by a different mechanism and may have a potential as therapeutic agents for subclinical mastitis.

Early Fuel Cell Market Deployments: ARRA and Combined (IAA, DLA, ARRA): Quarter 4 2013 Composite Data Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurtz, J.; Sprik, S.

2014-06-01

This report includes the composite data products (CDPs) for early fuel cell market deployments in quarter 4 of 2013. Results are presented for ARRA (projects funded by the American Recovery and Reinvestment Act of 2009 [ARRA]) and Combined (projects funded by DOE Interagency Agreements [IAA], Department of Defense Defense Logistics Agency [DLA], and ARRA).

Systemic and local bactericidal potentiality in late lactation Holstein-Friesian cows following a combined antibiotics and Enterococcus faecium SF68 dry-cow treatment.

PubMed

Tiantong, Attapol; Piamya, Piya; Chen, Shuen-Ei; Liu, Wen-Bor; Chang, Fang-Yu; Lin, Pei-Chi; Nagahata, Hajime; Chang, Chai-Ju

2015-08-01

Antibiotic dry-cow treatment contributes a major part to the total use of antibiotics in dairy herds. Enterococcus faecium strain SF68 (SF68) was of human origin but has been authorized in EU as probiotic feed additive. In the present study, one of the front and rear quarters of twelve late lactation Holstein-Friesian cows were infused once with a commercial antibiotic dry-cow formula (antibiotics quarter) on the first milk-stasis day (d 1), when the contrallateral quarters were infused with 5 x 10(8)-CFU SF68 plus half-dose antibiotic dry-cow formula (SF68/antibiotics quarter) meanwhile. Gelatinase level and cellular reactive oxygen species (ROS) production capacity were measured for blood and quarter secretion. The results showed that the count of blood total leukocytes minorly decreased on d 3 only but the microscopic somatic cell count (MSCC) continuously increased up to d 7, especially in SF68/antibiotics quarters. Plasma level of gelatinase A remained similar up to d 7 but gelatinase B was not detectable in plasma throughout the study. The level of gelatinase A in quarter secretion increased up to d 7 but gelatinase B increased even more drastically, especially in SF68/antibiotics quarters. The ROS production capacity of blood leukocytes increased temporarily only on d 3, but that of milk cells continuously increased up to d 7, especially in SF68/antitiotics quarters. Overall, late lactation Holstein-Friesian cows were systemically adaptable to the combined antibiotics and SF68 dry-cow treatment, while the local bactericidal potentiality in mammary gland was actively responsive to additional SF68 intramammary treatment.

Early host response in the mammary gland after experimental Streptococcus uberis challenge in heifers.

PubMed

de Greeff, Astrid; Zadoks, Ruth; Ruuls, Lisette; Toussaint, Mathilda; Nguyen, Thi Kim Anh; Downing, Alison; Rebel, Johanna; Stockhofe-Zurwieden, Norbert; Smith, Hilde

2013-06-01

Streptococcus uberis is a highly prevalent causative agent of bovine mastitis, which leads to large economic losses in the dairy industry. The aim of this study was to examine the host response during acute inflammation after experimental challenge with capsulated Strep. uberis. Gene expression in response to Strep. uberis was compared between infected and control quarters in 3 animals. All quarters (n=16) were sampled at 16 different locations. Microarray data showed that 239 genes were differentially expressed between infected and control quarters. No differences in gene expression were observed between the different locations. Microarray data were confirmed for several genes using quantitative PCR analysis. Genes differentially expressed due to early Strep. uberis mastitis represented several stages of the process of infection: (1) pathogen recognition; (2) chemoattraction of neutrophils; (3) tissue repair mechanisms; and (4) bactericidal activity. Three different pathogen recognition genes were induced: ficolins, lipopolysaccharide binding protein, and toll-like receptor 2. Calgranulins were found to be the most strongly upregulated genes during early inflammation. By histology and immunohistochemistry, we demonstrated that changes in gene expression in response to Strep. uberis were induced both in infiltrating somatic milk cells and in mammary epithelial cells, demonstrating that the latter cell type plays a role in milk production as well as immune responsiveness. Given the rapid development of inflammation or mastitis after infection, early diagnosis of (Strep. uberis) mastitis is required for prevention of disease and spread of the pathogen. Insight into host responses could help to design immunomodulatory therapies to dampen inflammation after (early) diagnosis of Strep. uberis mastitis. Future research should focus on development of these early diagnostics and immunomodulatory components for mastitis treatment. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Therapeutic effects of antimicrobial treatment during lactation of recently acquired bovine subclinical mastitis: two linked randomized field trials.

PubMed

van den Borne, B H P; van Schaik, G; Lam, T J G M; Nielen, M

2010-01-01

Two linked randomized field trials were performed on 39 herds in the Netherlands to 1) determine therapeutic effects of antimicrobial treatment of recently acquired subclinical mastitis (RASCM) during lactation, 2) evaluate the effect of duration of subclinical mastitis on therapeutic outcome, and 3) identify factors related to the therapeutic success of RASCM. Cows with a first elevated composite somatic cell count (CSCC) after 2 consecutive low CSCC measurements were eligible for enrollment in trial 1 (treatment at the first elevated CSCC). Quarter milk samples were collected to determine bacteriological status for major pathogens and coagulase-negative staphylococci. Cows with one or more culture-positive quarters with a quarter somatic cell count (QSCC) >or=100,000 cells/mL were defined to have RASCM and were randomly assigned treatment or control (no treatment). Untreated cows from trial 1 that had a second elevated CSCC at the next milk recording were eligible for enrollment in trial 2 (treatment at the second elevated CSCC). In trial 2, staphylococci-positive cows (Staphylococcus aureus and coagulase-negative staphylococci) were randomly assigned to treatment or control. Farmers used their own treatment protocols to treat quarters in both trials. Bacteriological cure was defined as absence of the pathogen identified pre-intervention in 2 samples post-intervention; QSCC, CSCC, and milk yield were also analyzed. Hierarchical logistic and linear models were used to determine therapeutic effects and to identify factors related to therapy outcome. Treated quarters had a higher bacteriological cure rate than control quarters for all pathogens in both trials. Treatment resulted in lower QSCC and CSCC, whereas milk yield was not affected by treatment. Bacteriological cure of RASCM was better in quarters with a low QSCC pre-intervention and in coagulase-negative staphylococci-positive quarters. Control quarters with a single culture-positive sample pre-intervention also had a higher bacteriological cure than control quarters with >or=2 culture-positive samples. Time of antimicrobial treatment affected bacteriological cure for penicillin-sensitive Staph. aureus. Bacteriological cure tended to be higher for Staph. aureus after treatment at the first elevated CSCC compared with treatment at the second elevated CSCC. Thus, early treatment of Staph. aureus might be more effective than later treatment. Copyright 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Quarterly Report: Microchannel-Assisted Nanomaterial Deposition Technology for Photovoltaic Material Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palo, Daniel R.

2011-04-26

Quarterly report to ITP for Nanomanufacturing program. Report covers FY11 Q2. The primary objective of this project is to develop a nanomanufacturing process which will reduce the manufacturing energy, environmental discharge, and production cost associated with current nano-scale thin-film photovoltaic (PV) manufacturing approaches. The secondary objective is to use a derivative of this nanomanufacturing process to enable greener, more efficient manufacturing of higher efficiency quantum dot-based photovoltaic cells now under development. The work is to develop and demonstrate a scalable (pilot) microreactor-assisted nanomaterial processing platform for the production, purification, functionalization, and solution deposition of nanomaterials for photovoltaic applications. The highmore » level task duration is shown. Phase I consists of a pilot platform for Gen II PV films along with parallel efforts aimed at Gen III PV quantum dot materials. Status of each task is described.« less

12 CFR 1777.10 - Developments prompting supervisory response.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) An Enterprise's publicly reported net income for the most recent calendar quarter is less than one-half of its average quarterly net income for any four-quarter period during the prior eight quarters... than one-half of its average NIM for any four-quarter period during the prior eight quarters; (d) For...

12 CFR 1777.10 - Developments prompting supervisory response.

Code of Federal Regulations, 2010 CFR

2010-01-01

... less than the national HPI four quarters previously, or for any Census Division or Divisions in which... more than five percent less than the HPI for that Division or Divisions four quarters previously; (b...-half of its average quarterly net income for any four-quarter period during the prior eight quarters...

The microbiota of water buffalo milk during mastitis

PubMed Central

Catozzi, Carlotta; Sanchez Bonastre, Armand; Francino, Olga; Lecchi, Cristina; De Carlo, Esterina; Vecchio, Domenico; Martucciello, Alessandra; Fraulo, Pasquale; Bronzo, Valerio; Cuscó, Anna; D’Andreano, Sara

2017-01-01

The aim of this study was to define the microbiota of water buffalo milk during sub-clinical and clinical mastitis, as compared to healthy status, by using high-throughput sequencing of the 16S rRNA gene. A total of 137 quarter samples were included in the experimental design: 27 samples derived from healthy, culture negative quarters, with a Somatic Cell Count (SCC) of less than 200,000 cells/ml; 27 samples from quarters with clinical mastitis; 83 samples were collected from quarters with subclinical mastitis, with a SCC number greater of 200,000 cells/ml and/or culture positive for udder pathogens, without clinical signs of mastitis. Bacterial DNA was purified and the 16S rRNA genes were individually amplified and sequenced. Significant differences were found in milk samples from healthy quarters and those with sub-clinical and clinical mastitis. The microbiota diversity of milk from healthy quarters was richer as compared to samples with sub-clinical mastitis, whose microbiota diversity was in turn richer as compared to those from clinical mastitis. The core microbiota of water buffalo milk, defined as the asset of microorganisms shared by all healthy milk samples, includes 15 genera, namely Micrococcus, Propionibacterium, 5-7N15, Solibacillus, Staphylococcus, Aerococcus, Facklamia, Trichococcus, Turicibacter, 02d06, SMB53, Clostridium, Acinetobacter, Psychrobacter and Pseudomonas. Only two genera (Acinetobacter and Pseudomonas) were present in all the samples from sub-clinical mastitis, and no genus was shared across all in clinical mastitis milk samples. The presence of mastitis was found to be related to the change in the relative abundance of genera, such as Psychrobacter, whose relative abundance decreased from 16.26% in the milk samples from healthy quarters to 3.2% in clinical mastitis. Other genera, such as SMB53 and Solibacillus, were decreased as well. Discriminant analysis presents the evidence that the microbial community of healthy and clinical mastitis could be discriminated on the background of their microbiota profiles. PMID:28926595

The microbiota of water buffalo milk during mastitis.

PubMed

Catozzi, Carlotta; Sanchez Bonastre, Armand; Francino, Olga; Lecchi, Cristina; De Carlo, Esterina; Vecchio, Domenico; Martucciello, Alessandra; Fraulo, Pasquale; Bronzo, Valerio; Cuscó, Anna; D'Andreano, Sara; Ceciliani, Fabrizio

2017-01-01

The aim of this study was to define the microbiota of water buffalo milk during sub-clinical and clinical mastitis, as compared to healthy status, by using high-throughput sequencing of the 16S rRNA gene. A total of 137 quarter samples were included in the experimental design: 27 samples derived from healthy, culture negative quarters, with a Somatic Cell Count (SCC) of less than 200,000 cells/ml; 27 samples from quarters with clinical mastitis; 83 samples were collected from quarters with subclinical mastitis, with a SCC number greater of 200,000 cells/ml and/or culture positive for udder pathogens, without clinical signs of mastitis. Bacterial DNA was purified and the 16S rRNA genes were individually amplified and sequenced. Significant differences were found in milk samples from healthy quarters and those with sub-clinical and clinical mastitis. The microbiota diversity of milk from healthy quarters was richer as compared to samples with sub-clinical mastitis, whose microbiota diversity was in turn richer as compared to those from clinical mastitis. The core microbiota of water buffalo milk, defined as the asset of microorganisms shared by all healthy milk samples, includes 15 genera, namely Micrococcus, Propionibacterium, 5-7N15, Solibacillus, Staphylococcus, Aerococcus, Facklamia, Trichococcus, Turicibacter, 02d06, SMB53, Clostridium, Acinetobacter, Psychrobacter and Pseudomonas. Only two genera (Acinetobacter and Pseudomonas) were present in all the samples from sub-clinical mastitis, and no genus was shared across all in clinical mastitis milk samples. The presence of mastitis was found to be related to the change in the relative abundance of genera, such as Psychrobacter, whose relative abundance decreased from 16.26% in the milk samples from healthy quarters to 3.2% in clinical mastitis. Other genera, such as SMB53 and Solibacillus, were decreased as well. Discriminant analysis presents the evidence that the microbial community of healthy and clinical mastitis could be discriminated on the background of their microbiota profiles.

Association between isolation of Staphylococcus aureus one week after calving and milk yield, somatic cell count, clinical mastitis, and culling through the remaining lactation.

PubMed

Whist, Anne Cathrine; Osterås, Olav; Sølverød, Liv

2009-02-01

Cows with isolation of Staphylococcus aureus approximately 1 week after calving and milk yield, somatic cell count (SCC), clinical mastitis (CM), and culling risk through the remaining lactation were assessed in 178 Norwegian dairy herds. Mixed models with repeated measures were used to compare milk yield and SCC, and survival analyses were used to estimate the hazard ratio for CM and culling. On average, cows with an isolate of Staph. aureus had a significantly higher SCC than culture-negative cows. If no post-milking teat disinfection (PMTD) was used, the mean values of SCC were 42,000, 61,000, 68,000 and 77,000 cells/ml for cows with no Staph. aureus isolate, with Staph. aureus isolated in 1 quarter, in 2 quarters and more than 2 quarters respectively. If iodine PMTD was used, SCC means were 36,000; 63,000; 70,000 and 122,000, respectively. Primiparous cows testing positive for Staph. aureus had the same milk yield curve as culture-negative cows, except for those with Staph. aureus isolated in more than 2 quarters. They produced 229 kg less during a 305-d lactation. Multiparous cows with isolation of Staph. aureus in at least 1 quarter produced 94-161 kg less milk in 2nd and >3rd parity, respectively, and those with isolation in more than 2 quarters produced 303-390 kg less than multiparous culture-negative animals during a 305-d lactation. Compared with culture-negative cows, the hazard ratio for CM and culling in cows with isolation of Staph. aureus in at least 1 quarter was 2.0 (1.6-2.4) and 1.7 (1.5-1.9), respectively. There was a decrease in the SCC and in the CM risk in culture-negative cows where iodine PMTD had been used, indicating that iodine PMTD has a preventive effect on already healthy cows. For cows testing positive for Staph. aureus in more than 2 quarters at calving, iodine PMTD had a negative effect on the CM risk and on the SCC through the remaining lactation.

CSSEDC Quarterly. 1989.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1989-01-01

These four issues of the CSSEDC Quarterly (Conference for Secondary School English Department Chairpersons) represent the quarterly for 1989. Articles in number 1 deal with professional development, and include: "Sharing Expertise within a Department" (Martha R. Dolly); "Empowerment Develops a Computer Writing Center" (Norman…

Special Inspector General for Iraq Reconstruction. Quarterly Report and Semiannual Report to the United States Congress

DTIC Science & Technology

2008-01-30

Energy Fusion Cell, and allocations include $110 million for oil pipeline exclusion zones—which aim to prevent illegal tapping and sabotage of...sectors in Iraq. This quarter SIGIR highlights two of these programs: the electronic funds transfer ( EFT ) system and U.S. advisory support provided to...the Iraq Stock Exchange. eleCTroniC funds Transfer SIGIR noted last quarter that Iraq finally acti- vated an electronic funds transfer ( EFT ) system

Special Inspector General for Iraq Reconstruction: Quarterly Report and Semiannual Report to the United States Congress

DTIC Science & Technology

2008-01-30

Cell, and allocations include $110 million for oil pipeline exclusion zones—which aim to prevent illegal tapping and sabotage of pipelines—$51...This quarter SIGIR highlights two of these programs: the electronic funds transfer ( EFT ) system and U.S. advisory support provided to the Iraq Stock...Exchange. eleCTroniC funds Transfer SIGIR noted last quarter that Iraq finally acti- vated an electronic funds transfer ( EFT ) system. The United

Novel carbon-ion fuel cells. Quarterly technical report, April--June 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocks, F.H.

1996-11-01

This report presents research to develop a new type of of fuel cell using a solid electrolyte that transports carbon ions. This new class of fuel cell would use solid C dissolved in molten metal (carbide) as a fuel reservoir and anode; thus expensive gas or liquid fuel would not be required. Thermodynamic efficiency of carbon-ion fuel cells is reviewed, as are electrolyte crystal structures (oxide and fluorite carbides). The sequence of laboratory research procedures for developing a solid C-ion electrolyte and to determine the ionic conductivity of C ions therein is outlined; results of the laboratory research to datemore » are summarized, including XRD analysis of crystal structures and transition temperatures of carbides (La, Ce, Be, Al) and SIMS of carbon isotopes.« less

Using Phylogenetic Analysis to Detect Market Substitution of Atlantic Salmon for Pacific Salmon: An Introductory Biology Laboratory Experiment

ERIC Educational Resources Information Center

Cline, Erica; Gogarten, Jennifer

2012-01-01

We describe a laboratory exercise developed for the cell and molecular biology quarter of a year-long majors' undergraduate introductory biology sequence. In an analysis of salmon samples collected by students in their local stores and restaurants, DNA sequencing and phylogenetic analysis were used to detect market substitution of Atlantic salmon…

Performance evaluation of advanced battery technologies for electric vehicle applications

NASA Astrophysics Data System (ADS)

Deluca, W. H.; Tummillo, A. F.; Kulaga, J. E.; Webster, C. E.; Gillie, K. R.; Hogrefe, R. L.

1990-01-01

At the Argonne Analysis and Diagnostic Laboratory, advanced battery technology evaluations are performed under simulated electric vehicle operating conditions. During 1989 and the first quarter of 1990, single cell and multicell modules from seven developers were examined for the Department of Energy and Electric Power Research Institute. The results provide battery users, developers, and program managers with an interim measure of the progress being made in battery R&D programs, a comparison of battery technologies, and a source of basic data for modeling and continuing R&D. This paper summarizes the performance and life characterizations of two single cells and seven 3- to 960-cell modules that encompass six technologies (Na/S, Ni/Fe, Ni/Cd, Ni-metal hydride, lead-acid, and Zn/Br).

Silicon materials task of the low cost solar array project. Phase 3: Effect of impurities and processing on silicon solar cells

NASA Technical Reports Server (NTRS)

Hopkins, R. H.; Davis, J. R.; Blais, P. D.; Rohatgi, A.; Campbell, R. B.; Rai-Choudhury, P.; Mollenkopf, H. C.; Mccormick, J. R.

1979-01-01

The 13th quarterly report of a study entitled an Investigation of the Effects of Impurities and Processing on Silicon Solar Cells is given. The objective of the program is to define the effects of impurities, various thermochemical processes and any impurity-process interactions on the performance of terrestrial silicon solar cells. The Phase 3 program effort falls in five areas: (1) cell processing studies; (2) completion of the data base and impurity-performance modeling for n-base cells; (3) extension of p-base studies to include contaminants likely to be introduced during silicon production, refining or crystal growth; (4) anisotropy effects; and (5) a preliminary study of the permanence of impurity effects in silicon solar cells. The quarterly activities for this report focus on tasks (1), (3) and (4).

Automated Array Assembly, Phase 2

NASA Technical Reports Server (NTRS)

Carbajal, B. G.

1979-01-01

The Automated Array Assembly Task, Phase 2 of the Low Cost Silicon Solar Array Project is a process development task. The contract provides for the fabrication of modules from large area tandem junction cells (TJC). During this quarter, effort was focused on the design of a large area, approximately 36 sq cm, TJC and process verification runs. The large area TJC design was optimized for minimum I squared R power losses. In the TJM activity, the cell-module interfaces were defined, module substrates were formed and heat treated and clad metal interconnect strips were fabricated.

The ability of four strains of Streptococcus uberis to induce clinical mastitis after intramammary inoculation in lactating cows.

PubMed

Notcovich, S; deNicolo, G; Williamson, N B; Grinberg, A; Lopez-Villalobos, N; Petrovski, K R

2016-07-01

To compare the ability of four strains of Streptococcus uberis at two doses to induce clinical mastitis in lactating dairy cows after intramammary inoculation in order to evaluate their usefulness for future experimental infection models. Four field strains of S. uberis (26LB, S418, and S523 and SR115) were obtained from cows with clinical mastitis in the Wairarapa and Waikato regions of New Zealand. Twenty-four crossbred lactating cows, with no history of mastitis and absence of major pathogens following culture of milk samples, were randomly allocated to four groups (one per strain) of six cows. Each cow was infused (Day 0) in one quarter with approximately 10(4) cfu and in the contralateral quarter with approximately 10(6) cfu of the same strain. The other two quarters remained unchallenged. All four quarters were then inspected for signs of clinical mastitis, by palpation and observation of the foremilk, twice daily from Days 0-9, and composite milk samples were collected from Days 0-8 for analysis of somatic cell counts (SCC). Quarters were treated with penicillin when clinical mastitis was observed. Duplicate milk samples were collected and cultured on presentation of each clinical case and on Day 4 from challenged quarters with no clinical signs. Clinical mastitis was diagnosed in 26/48 (54%) challenged quarters. Challenge with strain S418 resulted in more cases of mastitis (12/12 quarters) than strains SR115 (7/12), 26LB (6/12) or S523 (1/12), and the mean interval from challenge to first diagnosis of mastitis was shorter for S418 than the other strains (p<0.001). The proportion of quarters from which S. uberis could be isolated after challenge was less for strain 26LB (1/6) than SR115 (6/7) (p<0.05), and SCC following challenge was lower for strain S523 than the other strains (p<0.05). There were significant differences between the strains in the proportion of quarters developing clinical mastitis, the interval to mastitis onset, SCC following challenge and the proportion of clinical cases from which S. uberis could be isolated. These results illustrate the difference in the ability of S. uberis strains to cause mastitis and the severity of the infections caused. Experimental challenge models can be used to compare infectivity and pathogenicity of different strains of mastitis-causing bacteria, the efficacy of pharmaceutical products and host-responses in a cost-effective manner.

Lactoferrin affects the adherence and invasion of Streptococcus dysgalactiae ssp. dysgalactiae in mammary epithelial cells.

PubMed

O'Halloran, Fiona; Beecher, Christine; Chaurin, Valerie; Sweeney, Torres; Giblin, Linda

2016-06-01

Streptococcus dysgalactiae ssp. dysgalactiae is an important causative agent of bovine mastitis worldwide. Lactoferrin is an innate immune protein that is associated with many functions including immunomodulatory, antiproliferative, and antimicrobial properties. This study aimed to investigate the interactions between lactoferrin and a clinical bovine mastitis isolate, Strep. dysgalactiae ssp. dysgalactiae DPC5345. Initially a deliberate in vivo bovine intramammary challenge was performed with Strep. dysgalactiae DPC5345. Results demonstrated a significant difference in lactoferrin mRNA levels in milk cells between the control and infused quarters 7h postinfusion. Milk lactoferrin levels in the Strep. dysgalactiae DPC5345 infused quarters were significantly increased compared with control quarters at 48h postinfusion. In vitro studies demonstrated that lactoferrin had a bacteriostatic effect on the growth of Strep. dysgalactiae DPC5345 and significantly decreased the ability of the bacteria to internalize into HC-11 mammary epithelial cells. Confocal microscopy images of HC-11 cells exposed to Strep. dysgalactiae and lactoferrin further supported this effect by demonstrating reduced invasion of bacteria to HC-11 cells. The combined data suggest that a bovine immune response to Strep. dysgalactiae infection includes a significant increase in lactoferrin expression in vivo, and based on in vitro data, lactoferrin limits mammary cell invasion of this pathogen by binding to the bacteria and preventing its adherence. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Novel carbon-ion fuel cells. Quarterly technical report No. 9, October 1, 1995--December 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocks, F.H.

1995-12-31

This report presents research to develop an entirely new, fundamentally different class of fuel cell using a solid electrolyte that transports carbon ions. This fuel cell would use solid carbon dissolved in molten metal as a fuel reservoir and anode; expensive gaseous or liquid fuel would not be required. Thermodynamic factors favor a carbon-ion fuel cell over other fuel cell designs: a combination of enthalpy, entropy, and Gibbs free energy makes the reaction of solid carbon and oxygen very efficient, and the entropy change allows this efficiency to slightly increase at high temperatures. The high temperature exhaust of the fuelmore » cell would make it useful as a ``topping cycle``, to be followed by conventional steam turbine systems.« less

Lunar synchronization of testicular development and steroidogenesis in rabbitfish.

PubMed

Rahman, M S; Takemura, A; Takano, K

2001-06-01

Lunar synchronization of testicular development in the golden rabbitfish, Siganus guttatus, was assessed by measuring changes in sperm motility and conditions in the seminal plasma, and by in vitro production of steroid hormones in testicular fragments and sperm preparations. The duration and percentage of sperm motility was low 1 week before spawning (the new moon), but increased significantly on the day of spawning (the first lunar quarter). During the first lunar quarter, the osmolality decreased, but Ca(2+) concentration increased in the seminal plasma. These results suggest that spermiation occurs rapidly towards the specific lunar phase. Testicular fragments and sperm preparations were incubated with human chorionic gonadotropin (hCG) and two precursor steroid hormones, 17alpha-hydroxyprogesterone (17alpha-OHP) and testosterone (T), during the two lunar phases. The production of 11-ketotestosterone (11-KT) increased significantly when the testicular fragments were incubated with hCG at the first lunar quarter, while incubation of sperm preparations with 17alpha-OHP during the same moon phase resulted in a significant increase in 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP) production in the medium. These results suggest that 11-KT is produced in the somatic cells of the testis under the influence of gonadotropin, and that sperm can convert 17alpha-OHP to DHP. Additionally, steroidogenic activity was considered to increase toward the specific lunar phase. The synchronous increase in testicular activity supports the hypothesis that lunar periodicity is a major factor for the testicular development of S. guttatus.

Variation in the composition of selected milk fraction samples from healthy and mastitic quarters, and its significance for mastitis diagnosis.

PubMed

Bansal, Baljinder K; Hamann, Joern; Grabowskit, Nils Th; Singh, Krishan B

2005-05-01

Seven variables--electrical conductivity (EC), somatic cell count (SCC), N-acetyl-beta-D-glucosaminidase (NAGase), lactose, protein, fat and pH--were compared in four quarter milk fractions (MF1: strict foremilk; MF2: first 12-15 ml foremilk; MF3: subsequent 40-45 ml milk; MF4: strippings) and in one cow composite milk sample (CC) per cow. The study used 142 quarters from 37 lactating cows of the German Black Pied breed. To rule out any possible effect due to management, animal physiology and analytical procedures, the collection and processing of milk samples from each cow was repeated for three consecutive days, and the means of 3-d values were used. All variables were affected significantly by milk fraction and udder health. Compared with foremilk, EC, lactose and protein levels in strippings decreased, while SCC, NAGase and fat increased. The pH of foremilk and strippings did not differ significantly in healthy or in mastitic quarters. The difference between MF1 and MF2 was significant for EC in mastitic quarters, and for SCC in healthy quarters only. In general, mastitis resulted in a significant increase in EC, SCC, NAGase and protein but in a decrease in lactose and fat contents of milk in one or more of the milk fractions studied. Comparison of cow composite milk samples from healthy and mastitic cows revealed the significance (P < 0.01) of udder health for EC, SCC and lactose. Of the different parameters that can distinguish between healthy and mastitic quarters or cows, EC could be used to classify 76% of quarters and 73% of cows correctly, while the lactose content permitted correct identification of 81% of quarters and 76% of cows. NAGase and pH could be used to determine the status of 73% and 61% of quarters, respectively. In general, the correlation observed in strippings was higher than in foremilk for almost all the variables studied. Surprisingly, EC, SCC, NAGase and lactose in milk from healthy quarters of mastitic cows (with at least one mastitic quarter) differed significantly (P < 0.05) from those from healthy quarters of cows with all four healthy quarters, indicating an inconsistent effect of mastitic quarters on neighbouring healthy quarters (quarter interdependence).

Catalyst and process development for the H/sub 2/ preparation from future fuel cell feedstocks. Quarterly progress report, October 1, 1978-December 31, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yarrington, R M; Feins, I R; Hwang, H S

1979-01-01

The work done under this contract in the last quarter of 1978 was concerned with Phase I, which involved preliminary catalyst and process evaluation. The processes under study are hydrogen assisted steam reforming (HASR), catalytic partial oxidation (CPO), and autothermal steam reforming (ATR). Existing Engelhard test units were modified to carry out preliminary runs using the first two processes. Technical analysis to support work in this area consisted of heat and material balances constrained by equilibrium considerations. In a third task, the steam reforming of methanol to produce hydrogen was studied over two commercial low-temperature shift catalysts. Aging runs indicatedmore » good initial performance on both catalysts, but methanol conversion started to decline after a few hundred hours on stream.« less

Novel carbon-ion fuel cells. Quarterly technical report No. 10, January 1, 1996--March 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocks, F.H.

1996-08-01

This report presents research to develop an entirely new, fundamentally different class of fuel cell using a solid electrolyte that transports carbon ions. This fuel cell would use solid carbon dissolved in molten metal as a fuel reservoir and anode; expensive gaseous or liquid fuel would not be required. A high temperature fuel cell based on a carbon ion membrane/electrolyte would operate in a way like yttria-doped zirconia solid oxide fuel cells; however, the fuel cell would transport the C ion from a fuel source to O{sub 2} in the atmosphere. Such fuel cells, operating above 1000 C, would producemore » an exhaust gas that could be fed directly into existing boilers, and could thus act as ``topping cycles`` to existing power plant steam cycles.« less

Evaluation of minor pathogen intramammary infection, susceptibility parameters, and somatic cell counts on the development of new intramammary infections with major mastitis pathogens.

PubMed

Reyher, K K; Dohoo, I R; Scholl, D T; Keefe, G P

2012-07-01

Major mastitis pathogens such as Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, and coliforms are usually considered more virulent and damaging to the udder than minor mastitis pathogens such as Corynebacterium spp. and coagulase-negative staphylococci (CNS). The current literature comprises several studies (n=38) detailing analyses with conflicting results as to whether intramammary infections (IMI) with the minor pathogens decrease, increase, or have no effect on the risk of a quarter acquiring a new IMI (NIMI) with a major pathogen. The Canadian Bovine Mastitis Research Network has a large mastitis database derived from a 2-yr data collection on a national cohort of dairy farms, and data from this initiative were used to further investigate the effect of IMI with minor pathogens on the acquisition of new major pathogen infections (defined as a culture-positive quarter sample in a quarter that had been free of that major pathogen in previous samples in the sampling period). Longitudinal milk samplings of clinically normal udders taken over several 6-wk periods as well as samples from cows pre-dry-off and postcalving were used to this end (n=80,397 quarter milk samples). The effects of CNS and Corynebacterium spp. on the major mastitis pathogens Staph. aureus, Strep. uberis, Strep. dysgalactiae, and coliform bacteria (Escherichia coli and Klebsiella spp.) were investigated using risk ratio analyses and multilevel logistic regression models. Quarter-, cow- and herd-level susceptibility parameters were also evaluated and were able to account for the increased susceptibility that exists within herds, cows and quarters, removing it from estimates for the effects of the minor pathogens. Increased quarter-level susceptibility was associated with increased risk of major pathogen NIMI for all pathogens except the coliforms. Increased somatic cell count was consistently associated with elevated risk of new major pathogen infections, but this was assumed to be a result of low sensitivity of bacteriology to diagnose major pathogen NIMI expediently and accurately. The presence of CNS in the sample 2 samplings before the occurrence of a NIMI increased the odds of experiencing a Staph. aureus NIMI 2.0 times, making the presence of CNS a risk factor for acquiring a Staph. aureus NIMI. Even with this extensive data set, power was insufficient to make a definitive statement about the effect of minor pathogen IMI on the acquisition of major pathogen NIMI. Definitively answering questions of this nature are likely to require an extremely large data set dedicated particularly to minor pathogen presence and NIMI with major pathogens. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

A Non-Cut Cell Immersed Boundary Method for Use in Icing Simulations

NASA Technical Reports Server (NTRS)

Sarofeen, Christian M.; Noack, Ralph W.; Kreeger, Richard E.

2013-01-01

This paper describes a computational fluid dynamic method used for modelling changes in aircraft geometry due to icing. While an aircraft undergoes icing, the accumulated ice results in a geometric alteration of the aerodynamic surfaces. In computational simulations for icing, it is necessary that the corresponding geometric change is taken into consideration. The method used, herein, for the representation of the geometric change due to icing is a non-cut cell Immersed Boundary Method (IBM). Computational cells that are in a body fitted grid of a clean aerodynamic geometry that are inside a predicted ice formation are identified. An IBM is then used to change these cells from being active computational cells to having properties of viscous solid bodies. This method has been implemented in the NASA developed node centered, finite volume computational fluid dynamics code, FUN3D. The presented capability is tested for two-dimensional airfoils including a clean airfoil, an iced airfoil, and an airfoil in harmonic pitching motion about its quarter chord. For these simulations velocity contours, pressure distributions, coefficients of lift, coefficients of drag, and coefficients of pitching moment about the airfoil's quarter chord are computed and used for comparison against experimental results, a higher order panel method code with viscous effects, XFOIL, and the results from FUN3D's original solution process. The results of the IBM simulations show that the accuracy of the IBM compares satisfactorily with the experimental results, XFOIL results, and the results from FUN3D's original solution process.

State-of-the-Art Fuel Cell Voltage Durability and Cost Status: 2018 Composite Data Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saur, Genevieve; Kurtz, Jennifer M; Dinh, Huyen N

This publication includes 18 composite data products (CDPs) for fuel cell technology status, focusing on state-of-the-art fuel cell voltage durability and cost with data through the fourth quarter of 2017.

Unit Cells

ERIC Educational Resources Information Center

Olsen, Robert C.; Tobiason, Fred L.

1975-01-01

Describes the construction of unit cells using clear plastic cubes which can be disassembled, and one inch cork balls of various colors, which can be cut in halves, quarters, or eighths, and glued on the inside face of the cube, thus simulating a unit cell. (MLH)

Impact of intramammary treatment on gene expression profiles in bovine Escherichia coli mastitis.

PubMed

Sipka, Anja; Klaessig, Suzanne; Duhamel, Gerald E; Swinkels, Jantijn; Rainard, Pascal; Schukken, Ynte

2014-01-01

Clinical mastitis caused by E. coli accounts for significant production losses and animal welfare concerns on dairy farms worldwide. The benefits of therapeutic intervention in mild to moderate cases are incompletely understood. We investigated the effect of intramammary treatment with cefapirin alone or in combination with prednisolone on gene expression profiles in experimentally-induced E. coli mastitis in six mid-lactating Holstein Friesian cows. Cows were challenged with E. coli in 3 quarters and received 4 doses of 300 mg cefapirin in one quarter and 4 doses of 300 mg cefapirin together with 20 mg prednisolone in another quarter. At 24 h (n = 3) or 48 h (n = 3) post-challenge, tissue samples from control and treated quarters were collected for microarray analysis. Gene expression analysis of challenged, un-treated quarters revealed an up-regulation of transcripts associated with immune response functions compared to un-challenged quarters. Both treatments resulted in down-regulation of these transcripts compared to challenged, un-treated quarters most prominently for genes representing Chemokine and TLR-signaling pathways. Gene expression of Lipopolysaccharide Binding Protein (LBP), CCL2 and CXCL2 were only significantly down-regulated in cefapirin-prednisolone-treated quarters compared to un-treated controls. Down-regulation of chemokines was further confirmed on the basis of protein levels in milk whey for CXCL1, CXCL2 and CXCL8 in both treatments with a greater decrease in cefapirin-prednisolone-treated quarters. The data reveal a significant effect of treatment on cell recruitment with a more pronounced effect in cefapirin-prednisolone treated quarters. Provided a rapid bacteriological clearance, combination therapy may prevent neutrophil-induced tissue damage and promote recovery of the gland.

Short communication: role of Mycoplasma arginini in mastitis caused by Streptococcus dysgalactiae.

PubMed

Stipkovits, Laszlo; Somogyi, Maria; Asvanyi, Balazs; Toth, Agnes; Szathmary, Susan

2013-03-01

We performed a comparative study on the development of mastitis induced by Mycoplasma arginini or Streptococcus dysgalactiae after challenging the cows. Mycoplasma arginini did not cause any clinical symptoms on its own, resulting in only a transient increase of somatic cell count (SCC; increase ranging from 0.5 × 10(6) to 0.8 × 10(6) cells/mL) and a slight decrease of milk production (10%) for 5 d. In contrast, Strep. dysgalactiae induced more severe clinical signs in animals and SCC increased to 1.60 × 10(6) to 2.11 × 10(6) cells/mL for 10 d. In addition, milk production decreased (22.9 to 27.0%) for 10 d. After 3 mo (2 mo after the first challenge), animals that were challenged previously with M. arginini were rechallenged with Strep. dysgalactiae. Severe clinical mastitis developed, with very high SCC (5.00 × 10(6) to 21.5 × 10(6) cells/mL), and a very significant reduction of milk production (28.6 to 68.7%), which lasted more than 4 wk, was observed. The severe clinical mastitis developed not only in cows inoculated with Strep. dysgalactiae andM. arginini in the same udder quarter but also in cows infected in the quarter previously not challenged with mycoplasma. Cows challenged first with Strep. dysgalactiae and rechallenged with M. arginini 2 mo later developed only slight changes in both SCC and milk production, similar to those when the cows were challenged with M. arginini alone. We conclude that M. arginini infection does not cause remarkable mastitis (characterized by decrease in milk production and increase of SCC) but it significantly predisposes animals to infection with Strep. dysgalactiae, leading to severe clinical mastitis. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Effect of intramammary infusion of chitosan hydrogels at drying-off on bovine mammary gland involution.

PubMed

Lanctôt, S; Fustier, P; Taherian, A R; Bisakowski, B; Zhao, X; Lacasse, P

2017-03-01

The transition from lactation to the dry period in dairy cows is a period of high risk for acquiring new intramammary infections. This risk is reduced when the involution of the mammary gland is completed. Accordingly, approaches that speed up the involution process after drying-off could reduce the incidence of mastitis. The current study aimed to develop a biological response modifier that could be injected into cow teats to promote immune cell migration and speed up involution. Chitosan, a natural polysaccharide derived from chitin, is able to trigger host innate immunity. We developed 2 formulations made from either high- or low-viscosity chitosan. Both are liquid at room temperature but form a hydrogel at body temperature. In the first experiment, each udder quarter of 7 Holstein cows in late lactation was randomly assigned at drying-off to receive one of the following intramammary infusions: 2.5 or 5 mL of 5% (wt/vol) low-viscosity chitosan hydrogel, 5 mL of 5% high-viscosity chitosan hydrogel, or 5 mL of water. Milk (mammary secretion) samples were collected from each quarter on d -4, -1 (drying-off), 1, 3, 5, 7, and 10. Milk somatic cell counts and the concentrations of involution markers such as BSA, lactate dehydrogenase, and lactoferrin were measured in each sample. In comparison with the control, the chitosan hydrogel infusions significantly hastened the increases in somatic cell counts, BSA and lactoferrin concentrations, and lactate dehydrogenase activity in mammary secretions. No major differences between sources or volumes of chitosan were observed for the measured parameters. The compatibility of this approach with an internal teat sealant was verified in the second experiment. Each udder quarter of 8 Holstein cows was randomly assigned at drying-off to receive one of the following intramammary infusions: 5 mL of 2% low-viscosity chitosan hydrogel, 4 g of an internal teat sealant, a combination of sealant and chitosan, or 5 mL of water. Milk (mammary secretion) samples were collected from each quarter on d -4, -1 (drying-off), 5, and 10 to measure involution markers. These results suggest that chitosan hydrogel infusion hastened mammary gland involution and activate immune response, which may reduce the risk of acquiring new intramammary infections during the drying-off period. Those results were not affected by the presence of the teat sealant, showing that both approaches are fully compatible and could be used in combination. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

N-acetyl -β-D-glucosaminidase activity in cow milk as an indicator of mastitis.

PubMed

Hovinen, Mari; Simojoki, Heli; Pösö, Reeta; Suolaniemi, Jenni; Kalmus, Piret; Suojala, Leena; Pyörälä, Satu

2016-05-01

Activity of lysosomal N-acetyl-β-d-glucosaminidase (NAGase) in milk has been used as an indicator of bovine mastitis. We studied NAGase activity of 808 milk samples from healthy quarters and quarters of cows with spontaneous subclinical and clinical mastitis. Associations between milk NAGase activity and milk somatic cell count (SCC), mastitis causing pathogen, quarter, parity, days in milk (DIM) and season were studied. In addition, the performance of NAGase activity in detecting clinical and subclinical mastitis and distinguishing infections caused by minor and major bacteria was investigated. Our results indicate that NAGase activity can be used to detect both subclinical and clinical mastitis with a high level of accuracy (0·85 and 0·99). Incomplete correlation between NAGase activity and SCC suggests that a substantial proportion of NAGase activity comes from damaged epithelial cells of the udder in addition to somatic cells. We therefore recommend determination of NAGase activity from quarter foremilk after at least six hours from the last milking using the method described. Samples should be frozen before analysis. NAGase activity should be interpreted according to DIM, at least during the first month of lactation. Based on the results of the present study, a reference value for normal milk NAGase activity of 0·1-1·04 pmoles 4-MU/min/μl for cows with ≥30 DIM (196 samples) could be proposed. We consider milk NAGase activity to be an accurate indicator of subclinical and clinical mastitis.

Defense Attache Saigon: RVNAF Quarterly Assessment, 1st Quarter FY75

DTIC Science & Technology

1974-11-01

CONFIDENTIAL ___ has been realized and a new computation of requirements methodology has been developed. Improved repair capability at ATLC and the Air ... Asia Ccrtcactor (Taiwan) have also reduced the dollar value "of AIMI buy requirements from CONUS. Comparison of quarterly * requirements follows

An imbalanced parental genome ratio affects the development of rice zygotes.

PubMed

Toda, Erika; Ohnishi, Yukinosuke; Okamoto, Takashi

2018-04-27

Upon double fertilization, one sperm cell fuses with the egg cell to form a zygote with a 1:1 maternal-to-paternal genome ratio (1m:1p), and another sperm cell fuses with the central cell to form a triploid primary endosperm cell with a 2m:1p ratio, resulting in formation of the embryo and the endosperm, respectively. The endosperm is known to be considerably sensitive to the ratio of the parental genomes. However, the effect of an imbalance of the parental genomes on zygotic development and embryogenesis has not been well studied, because it is difficult to reproduce the parental genome-imbalanced situation in zygotes and to monitor the developmental profile of zygotes without external effects from the endosperm. In this study, we produced polyploid zygotes with an imbalanced parental genome ratio by electro-fusion of isolated rice gametes and observed their developmental profiles. Polyploid zygotes with an excess maternal gamete/genome developed normally, whereas approximately half to three-quarters of polyploid zygotes with a paternal excess showed developmental arrests. These results indicate that paternal and maternal genomes synergistically serve zygote development with distinct functions, and that genes with monoallelic expression play important roles during zygotic development and embryogenesis.

12 CFR 1777.10 - Developments prompting supervisory response.

Code of Federal Regulations, 2014 CFR

2014-01-01

...: (a) OFHEO's national House Price Index (HPI) for the most recent quarter is more than two percent... securities guaranteed by an enterprise, the HPI for the most recent quarter for such Division or Divisions is...) An Enterprise's publicly reported net income for the most recent calendar quarter is less than one...

12 CFR 1777.10 - Developments prompting supervisory response.

Code of Federal Regulations, 2012 CFR

2012-01-01

...: (a) OFHEO's national House Price Index (HPI) for the most recent quarter is more than two percent... securities guaranteed by an enterprise, the HPI for the most recent quarter for such Division or Divisions is...) An Enterprise's publicly reported net income for the most recent calendar quarter is less than one...

12 CFR 1777.10 - Developments prompting supervisory response.

Code of Federal Regulations, 2013 CFR

2013-01-01

...: (a) OFHEO's national House Price Index (HPI) for the most recent quarter is more than two percent... securities guaranteed by an enterprise, the HPI for the most recent quarter for such Division or Divisions is...) An Enterprise's publicly reported net income for the most recent calendar quarter is less than one...

Evaluation of a lysostaphin-fusion protein as a dry-cow therapy for Staphylococcus aureus mastitis in dairy cattle.

PubMed

Hoernig, K J; Donovan, D M; Pithua, P; Williams, F; Middleton, J R

2016-06-01

This study evaluated the efficacy of a recombinant lysostaphin fused to a protein transduction domain (rLYS-PTD) as a dry-cow therapy for the treatment of experimentally induced chronic, subclinical Staphylococcus aureus mastitis. Twenty-two Holstein dairy cows were experimentally infected with Staph. aureus in a single pair of diagonal mammary quarters approximately 45d before dry off. Staphylococcus aureus-infected mammary quarters of cows were randomly assigned to 1 of 2 treatment groups at dry off: (1) 279mg of rLYS-PTD in 50mL of vehicle (n=11 cows; 22 quarters) or (2) 50mL of vehicle solution (n=11 cows; 22 quarters) by intramammary infusion. All cows were followed for 30d postpartum to determine cure rates using bacteriologic culture, somatic cell counts, and clinical mastitis scores. No cures were recorded in either the treatment or control groups. Milk somatic cell count, bacterial colony counts, and mastitis scores did not significantly differ between treatment groups. In conclusion, rLYS-PTD was not an effective dry-cow therapeutic for chronic, subclinical Staph. aureus mastitis at the tested dose and formulation. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

US energy industry financial developments, 1993 first quarter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-06-25

Net income for 259 energy companies-- including, 20 major US petroleum companies-- rose 38 percent between the first quarter of 1992 and the first quarter of 1993. An increased level of economic activity, along with colder weather, helped lift the demand for natural gas. crude oil, coal, and electricity. The sharp rise in the domestic price of natural gas at the wellhead relative to the year-ago quarter was the most significant development in US energy during the first quarter. As a consequence of higher natural gas prices, the upstream segment of the petroleum industry reported large gains in income, whilemore » downstream income rose due to higher refined product demand. Increased economic activity and higher weather-related natural gas demand also led to improvements in income for the rate-regulated energy segment. However, declining domestic oil production continued to restrain upstream petroleum industry earnings growth, despite a moderate rise in crude oil prices.« less

Development of an Acetate-Fed or Sugar-Fed Microbial Power Generator for Military Bases

DTIC Science & Technology

2011-01-01

quarter. We tested graphite and stainless steel as anode materials for ARB growth, showing the greater suitability of carbon fibers as anode material...microbial electrolysis cells (MECs) with graphite rods and stainless steel meshes as anodes to select the optimum material for use in MFC modules to...be tested in the future. We selected meshes made from 316-grade stainless steel for these initial studies. We conducted several trials with the MECs

Automotive Stirling engine development program

NASA Technical Reports Server (NTRS)

Ernst, W.; Richey, A.; Farrell, R.; Riecke, G.; Smith, G.; Howarth, R.; Cronin, M.; Simetkosky, M.; Meacher, J.

1986-01-01

This is the ninth Semiannual Technical Progress Report prepared under the Automotive Stirling Engine Development Program. It covers the twenty-eighth and twenty-ninth quarters of activity after award of the contract. Quarterly Technical Progress Reports related program activities from the first through the thirteenth quarters; thereafter, reporting was changed to a Semiannual format. This report summarizes the study of higher-power kinematic Stirling engines for transportation use, development testing of Mod I Stirling engines, and component development activities. Component development testing included successful conical fuel nozzle testing and functional checkout of Mod II controls and auxiliaries on Mod I engine test beds. Overall program philosophy is outlined and data and test results are presented.

The selective treatment of clinical mastitis based on on-farm culture results: II. Effects on lactation performance, including clinical mastitis recurrence, somatic cell count, milk production, and cow survival.

PubMed

Lago, A; Godden, S M; Bey, R; Ruegg, P L; Leslie, K

2011-09-01

The objective of this multi-state, multi-herd clinical trial was to report on the efficacy of using an on-farm culture system to guide strategic treatment decisions in cows with clinical mastitis. The study was conducted in 8 commercial dairy farms ranging in size from 144 to 1,795 cows from Minnesota, Wisconsin, and Ontario, Canada. A total of 422 cows affected with mild or moderate clinical mastitis in 449 quarters were randomly assigned to either (1) a positive-control treatment program or (2) an on-farm culture-based treatment program. Quarter cases assigned to the positive-control group received immediate on-label intramammary treatment with cephapirin sodium. Quarters assigned to the culture-based treatment program were not treated until the results of on-farm culture were determined after 18 to 24h of incubation. Quarters in the culture-based treatment program that had gram-positive growth or a mixed infection were treated according to label instruction using intramammary cephapirin sodium. Quarters assigned to the culture-based treatment program that had gram-negative or no-growth did not receive intramammary therapy. It was already reported in a companion paper that the selective treatment of clinical mastitis based on on-farm culture results decreases antibiotic use by half and tends to decrease milk withholding time without affecting short-term clinical and bacteriological outcomes. The present article reports on long-term outcomes of the aforementioned study. No statistically significant differences existed between cases assigned to the positive-control program and cases assigned to the culture-based treatment program in risk and days for recurrence of clinical mastitis in the same quarter (35% and 78 d vs. 43% and 82 d), linear somatic cell count (4.2 vs. 4.4), daily milk production (30.0 vs. 30.7 kg), and risk and days for culling or death events (28% and 160 d vs. 32% and 137 d) for the rest of the lactation after enrollment of the clinical mastitis case. In summary, the selective treatment of clinical mastitis based on on-farm culture resulted in no differences in long-term outcomes, such as recurrence of clinical mastitis in the same quarter, somatic cell count, milk production, and cow survival for the rest of the lactation after clinical mastitis. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Four-Quarter School Year. Results of an Exploratory Study of the Four-Quarter School Year in Metropolitan Atlanta.

ERIC Educational Resources Information Center

Bentley, Ernest L; And Others

Six Atlanta, Georgia, school systems initiated a four-quarter school year program in 1968-69. An exploratory study was conducted to develop procedures and instruments for a comprehensive examination of the plan. Strong support exists in all groups interviewed -- superintendents and steering committee members, students, parents, teachers,…

Stationary Fuel Cell Systems Analysis | Hydrogen and Fuel Cells | NREL

Science.gov Websites

Post, Presented at the 2016 DOE Annual Merit Review Meeting (June 2016) Transportation Big Data Ainscough, Sam Sprik, and Matt Post (December 2015) Stationary Fuel Cell Evaluation: 2015 Annual Merit Quarter 4 of 2014, Genevieve Saur, Jennifer Kurtz, Chris Ainscough, Sam Sprik, and Matt Post (April 2015

Including the Group Quarters Population in the US Synthesized Population Database

PubMed Central

Chasteen, Bernadette M.; Wheaton, William D.; Cooley, Philip C.; Ganapathi, Laxminarayana; Wagener, Diane K.

2011-01-01

In 2005, RTI International researchers developed methods to generate synthesized population data on US households for the US Synthesized Population Database. These data are used in agent-based modeling, which simulates large-scale social networks to test how changes in the behaviors of individuals affect the overall network. Group quarters are residences where individuals live in close proximity and interact frequently. Although the Synthesized Population Database represents the population living in households, data for the nation’s group quarters residents are not easily quantified because of US Census Bureau reporting methods designed to protect individuals’ privacy. Including group quarters population data can be an important factor in agent-based modeling because the number of residents and the frequency of their interactions are variables that directly affect modeling results. Particularly with infectious disease modeling, the increased frequency of agent interaction may increase the probability of infectious disease transmission between individuals and the probability of disease outbreaks. This report reviews our methods to synthesize data on group quarters residents to match US Census Bureau data. Our goal in developing the Group Quarters Population Database was to enable its use with RTI’s US Synthesized Population Database in the Modeling of Infectious Diseases Agent Study. PMID:21841972

Milk amyloid A as a biomarker for diagnosis of subclinical mastitis in cattle

PubMed Central

Hussein, Hany Ahmed; El-Razik, Khaled Abd El-Hamid Abd; Gomaa, Alaa Mohamed; Elbayoumy, Mohamed Karam; Abdelrahman, Khaled A.; Hosein, H. I.

2018-01-01

Background and Aim: Mastitis is one of the most vital noteworthy monetary risks to dairy ranchers and affects reproductive performance in dairy cattle. However, subclinical mastitis (SCM) negatively affects milk quality and quantity and associated with economic losses as clinical mastitis. It is recognizable only by additional testing. Somatic cell count (SCC) is currently used worldwide for the screening of intramammary infection (IMI) infections. However, somatic cells (SC) are affected by numerous factors and not always correlate with infection of the udder. Therefore, the aim of the present study was to evaluate the milk amyloid A (MAA) in the milk of normal and SCM cows and compare the sensitivity of both MAA secretion and SCC in response to mammary gland bacterial infection. Materials and Methods: A total of 272 quarter milk samples collected from 68 Friesian cows after clinical examination for detection of clinical mastitis were employed in this study. All quarter milk samples (272) were subjected to bacteriological examination, while SCs were assessed in samples (220). Following SCC estimation and bacteriological examination, the apparently normal quarter milk samples were categorized into 7 groups and MAA concentration was estimated in normal and subclinical mastitic milk samples. Results: Prevalence of clinical mastitis was 19.12 % (52 quarters), while 80.88 % (220 quarters) were clinically healthy with normal milk secretion. Of those 220 clinically healthy quarter milk samples, 72 (32.73%) showed SCM as detected by SCC (SCC ≥500,000 cells/ml). The most prevalent bacteria detected in this study were streptococci (48.53%), Staphylococcus aureus (29.41%), Escherichia coli (36.76%), and coagulase-negative staphylococci (11.76%). Results of MAA estimation revealed a strong correlation between MAA secretion level and SCC in agreement with the bacteriological examination. Interestingly, there was a prompt increase in MAA concentration in Group III (G III) (group of milk samples had SCC ≤200,000 cells/ml and bacteriologically positive) than Group I (G I) (group of milk samples with SCC ≤500,000 cells/ml and bacteriologically negative), as MAA concentration in G III was about 4 times its concentration in G I. Conclusion: Our study provides a strong evidence for the significance of MAA measurement in milk during SCM, and MAA is more sensitive to IMI than SCC. This can be attributed to rapid and sensitive marker of inflammation. The advantage of MAA over other diagnostic markers of SCM is attributed the minute or even undetectable level of MAA in the milk of healthy animals, it is not influenced by factors other than mastitis, and could be estimated in preserved samples. Therefore, we recommend that estimation of MAA concentration in milk is a more useful diagnostic tool than SCC to detect SCM and to monitor the udder health in dairy cattle. PMID:29479155

Risk factors associated with short-term post-treatment outcomes of clinical mastitis.

PubMed

Pinzón-Sánchez, C; Ruegg, P L

2011-07-01

The objectives of this study were to characterize 60-d outcomes after treatment of mild (abnormal milk) and moderate (abnormal milk and abnormal udder) cases of clinical mastitis (CM) occurring in a single quarter of cows on Wisconsin farms (n=4) and to determine risk factors associated with those outcomes. Duplicate milk samples were collected from the affected quarter of each cow for microbiological analysis at the onset of CM (PRE) and 21 d later (POST). Cows were treated only in the affected quarter using an intramammary product containing 125 mg of ceftiofur. Bacteriological cure was defined as absence of pathogens in the POST sample obtained from the enrolled quarter. Recurrence was defined for the cow when CM occurred after the milk-withholding period for the enrolled case of CM. Retention in the herd was defined when a cow was retained within the herd for the 60-d follow-up period. Somatic cell count reduction (SCCR) was defined at the cow level as somatic cell count (SCC) below 200,000 cells/mL at the Dairy Herd Improvement Association test day occurring between 21 to 55 d post-treatment. The effects of farm, days in milk, parity, severity, microbiological diagnosis at PRE, previous milk yield, previous SCC, previous occurrence of CM and treatment duration on selected post-treatment outcomes were assessed using Chi-squared analysis and logistic regression. Microbiological results at PRE were distributed as: Escherichia coli (n=14), Klebsiella spp. (n=11), Enterobacter spp. (n=8), Serratia spp. (n=7), other gram-negative species (n=3), Streptococcus spp. (n=25), coagulase-negative staphylococci (n=4); Staphylococcus aureus (n=1); Streptococcus agalactiae (n=1), other gram-positive species (n=9), and culture negative (n=60). Treated quarters were more likely to experience bacteriological cure when the cow experienced CM for the first time in the lactation and when no pathogen was recovered from PRE milk samples obtained from the enrolled quarter. Parity and bacteriological cure were associated with the probability of recurrence. Greater milk yield at previous Dairy Herd Improvement test was the most important predictor for retention within the herd. When SCC before CM was >200,000 cells/mL the probability of having SCCR after treatment was decreased. When the case experienced bacteriological cure, the cow was less likely to experience recurrent cases and was more likely to have SCCR below 200,000 cells/mL. Post-treatment outcomes, such as recurrence and SCCR, are strongly associated with bacteriological cure and, when monitored, can be used to help determine if a treatment has been successful. Information about the etiology of CM, history of clinical and subclinical mastitis, and parity are useful to review when making strategic treatment decisions. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Special Issue on Powering the Future Force: New Power & Energy Technologies for the Warfighter (AMMTIAC Quarterly, Volume 4, Number 1 / WSTIAC Quarterly, Volume 9, Number 1)

DTIC Science & Technology

2009-04-27

an aromatic acidic polymer such as SPEEK or SPSf. Figure 5 shows four basic polymers in which benzimidazole (BIm), amino- benzimidazole (ABIm...Z., A. Manthiram, and M. D. Guiver, “Blend Membranes Based on Sulfonated Polyetheretherketone and Polysulfone Bearing Benzimidazole Side Groups for...Sulfonated Poly(ether ether ketone) and Polysulfone Bearing Benzimidazole Side Groups for Direct Methanol Fuel Cells,” Electrochemical and Solid State Letters

Father Presence and Educational Attainment: Dad as a Catalyst for High School Graduations

ERIC Educational Resources Information Center

Mackey, Bonnie; Mackey, Wade C.

2012-01-01

The role of the on-going social father in America has received increased attention in the last quarter century. In some quarters, the U.S. father has been viewed as supernumerary or optional. In other quarters, the U.S. father has been perceived to be essential to the optimum development of his children. Still other factions have been intermediate…

Some boundary-value problems for anisotropic quarter plane

NASA Astrophysics Data System (ADS)

Arkhypenko, K. M.; Kryvyi, O. F.

2018-04-01

To solve the mixed boundary-value problems of the anisotropic elasticity for the anisotropic quarter plane, a method based on the use of the space of generalized functions {\\Im }{\\prime }({\\text{R}}+2) with slow growth properties was developed. The two-dimensional integral Fourier transform was used to construct the system of fundamental solutions for the anisotropic quarter plane in this space and a system of eight boundary integral relations was obtained, which allows one to reduce the mixed boundary-value problems for the anisotropic quarter plane directly to systems of singular integral equations with fixed singularities. The exact solutions of these systems were found by using the integral Mellin transform. The asymptotic behavior of solutions was investigated at the vertex of the quarter plane.

Quality assessment of urban areas based on neural network modeling and GIS

NASA Astrophysics Data System (ADS)

Popova, Olga; Glebova, Julia; Pustovgar, Andrey

2018-03-01

In this article the authors carry out the research of the urban development areas structure and propose the system of its characteristics on the basis of sector affiliation of the municipal economy. The authors have developed an algorithm for quality assessment of urban development areas. The results of the research are presented on the example of several central quarters of Arkhangelsk city. The city's residential development was formed in the periods from 1900-1950, 1950-1980 and from 2002 to date. It is currently presented by low-rise wooden, homestead type residential houses and barracks-type houses; mid-rise and high-rise brick and panel buildings of typical development, buildings of large-panel housing construction. Structural SOM-analysis compiled separate quarters of Arkhangelsk into 5 groups with a high level of characteristic similarity: "Commercial", "Prospective complex development", "Sustainable development", "Perspective renovation of residential development", "Investment-unattractive". Typical development strategies for each group of quarters are determined. Most developed areas characterized by upward height. The development strategies for depressed areas is in a high-rise building, which show the economic, social and environmental benefits of upward growth of the city. Using GIS allows to visually reflect the state and assess the quality of the urban development area by the aggregate of all parameters, and also to assess the quality of the quarters for each sector.

"The Career Development Quarterly": A Centennial Retrospective

ERIC Educational Resources Information Center

Savickas, Mark L.; Pope, Mark; Niles, Spencer G.

2011-01-01

"The Career Development Quarterly" has been the premier journal in the field of vocational guidance and career intervention since its inception 100 years ago. To celebrate its centennial, 3 former editors trace its evolution from a modest and occasional newsletter to its current status as a major professional journal. They recount its history of…

Environmental Hazards Assessment Program. Quarterly report, January 1994--March 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-05-04

The objectives of the EHAP program are to: Develop a holistic, national basis for risk assessment, risk management and risk communication; Develop a pool of talented scientists and experts in cleanup activities, especially in human health aspects, and; Identify needs and develop programs addressing the critical shortage of well-educated, highly-skilled technical and scientific personnel to address the health oriented aspects of environmental restoration and waste management. This report describes activities and reports on progress for the third quarter of year two (January-March, 1994) of the grant. To better accomplish objectives, grant efforts are organized into three major elements: The Crossroadsmore » of Humanity Series; Research, Science and Education Programs; and Program Management. The Crossroads of Humanity Series charted a new course, incorporating lessons learned during previous quarters into a series of programs designed to address environmental issues in a real world setting. Reports are included on the various research programs with milestones and deliverables from the third quarter.« less

Summary of flat-plate solar array project documentation: Abstracts of published documents, 1975-1986, revision 1

NASA Technical Reports Server (NTRS)

Phillips, M. J.

1986-01-01

Abstracts of final reports, or the latest quarterly or annual, of the Flat-Plate Solar Array (FSA) Project Contractor of Jet Propulsion Laboratory (JPL) in-house activities are presented. Also presented is a list of proceedings and publications, by author, of work connected with the project. The aim of the program has been to stimulate the development of technology that will enable the private sector to manufacture and widely use photovoltaic systems for the generation of electricity in residential, commercial, industrial, and Government applications at a cost per watt that is competitive with utility generated power. FSA Project activities have included the sponsoring of research and development efforts in silicon refinement processes, advanced silicon sheet growth techniques, higher efficiency solar cells, solar cell/module fabrication processes, encapsulation, module/array engineering and reliability, and economic analyses.

ITS at a glance, volume 1, number 1.

DOT National Transportation Integrated Search

1996-04-01

ITS at a glance is a quarterly newsletter produced by the U.S. Department of Transportation's Intelligent Transportation Systems (ITS) Joint Program Office (JPO). This quarterly publication will highlight and share major ITS developments within USDOT...

EELV reliability : building on experience : first quarter 2002 Quarterly Launch Report

DOT National Transportation Integrated Search

2002-01-01

The National Space Transportation Policy, signed by President Clinton on August 5, 1994, gave the National Aeronautics and Space Administration (NASA) responsibility for reusable launch vehicle development, while tasking the Department of Defense (Do...

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.

PubMed

Smith, E N; Ghia, E M; DeBoever, C M; Rassenti, L Z; Jepsen, K; Yoon, K-A; Matsui, H; Rozenzhak, S; Alakus, H; Shepard, P J; Dai, Y; Khosroheidari, M; Bina, M; Gunderson, K L; Messer, K; Muthuswamy, L; Hudson, T J; Harismendy, O; Barrett, C L; Jamieson, C H M; Carson, D A; Kipps, T J; Frazer, K A

2015-04-10

We examined genetic and epigenetic changes that occur during disease progression from indolent to aggressive forms of chronic lymphocytic leukemia (CLL) using serial samples from 27 patients. Analysis of DNA mutations grouped the leukemia cases into three categories: evolving (26%), expanding (26%) and static (47%). Thus, approximately three-quarters of the CLL cases had little to no genetic subclonal evolution. However, we identified significant recurrent DNA methylation changes during progression at 4752 CpGs enriched for regions near Polycomb 2 repressive complex (PRC2) targets. Progression-associated CpGs near the PRC2 targets undergo methylation changes in the same direction during disease progression as during normal development from naive to memory B cells. Our study shows that CLL progression does not typically occur via subclonal evolution, but that certain CpG sites undergo recurrent methylation changes. Our results suggest CLL progression may involve developmental processes shared in common with the generation of normal memory B cells.

The successes and future prospects of the linear antisense RNA amplification methodology.

PubMed

Li, Jifen; Eberwine, James

2018-05-01

It has been over a quarter of a century since the introduction of the linear RNA amplification methodology known as antisense RNA (aRNA) amplification. Whereas most molecular biology techniques are rapidly replaced owing to the fast-moving nature of development in the field, the aRNA procedure has become a base that can be built upon through varied uses of the technology. The technique was originally developed to assess RNA populations from small amounts of starting material, including single cells, but over time its use has evolved to include the detection of various cellular entities such as proteins, RNA-binding-protein-associated cargoes, and genomic DNA. In this Perspective we detail the linear aRNA amplification procedure and its use in assessing various components of a cell's chemical phenotype. This procedure is particularly useful in efforts to multiplex the simultaneous detection of various cellular processes. These efforts are necessary to identify the quantitative chemical phenotype of cells that underlies cellular function.

SATNET development and operation. Pluribus satellite IMP development. Remote site maintenance. Internet operations and maintenance. Mobile access terminal network. TCP for the HP3000. TCP-TAC. TCP for VAX-UNIX. Combined quarterly technical report

NASA Astrophysics Data System (ADS)

Bressler, R. D.

1981-11-01

This quarterly technical report describes work on the development of and experimentation with packet broadcast by satellite; on development of Pluribus Satellite IMPs; on a study of the technology of Remote Site Maintenance; on Internetwork monitoring; on shipboard satellite communications; and on the development of Transmission Control Protocols for the HP3000, TAC, and VAX-UNIX.

Short communication: Species group-specific predictors at the cow and quarter level for intramammary infection with coagulase-negative staphylococci in dairy cattle throughout lactation.

PubMed

De Visscher, A; Piepers, S; Supré, K; Haesebrouck, F; De Vliegher, S

2015-08-01

Coagulase-negative staphylococci (CNS) are frequently isolated from quarters with subclinical mastitis, teat apices, and the cows' environment. Virulence, ecology, epidemiological behavior, and effect on udder health vary between different CNS species. Staphylococcus chromogenes, Staph. simulans, and Staph. xylosus are frequently present in milk and have a more substantial effect on quarter milk somatic cell count than other species. Therefore, these species are considered the "more relevant" CNS. As species-specific factors associated with CNS intramammary infection (IMI) have not yet been identified and susceptibility for IMI differs between cows and quarters, this study aimed to identify predictors for CNS IMI at the cow and quarter level (some of them changing over time) with a specific focus on the aforementioned more relevant CNS. Precise data were available from a longitudinal study (3,052 observations from 344 quarters from 86 dairy cows belonging to 3 commercial dairy herds). All CNS were molecularly identified to the species level, and multivariable, multilevel logistic regression models taking into account the longitudinal nature of the data, were fit to study the likelihood of infection. Staphylococcus chromogenes, Staph. xylosus, and Staph. cohnii were the most frequently isolated species from CNS IMI in older cows, whereas Staph. chromogenes, Staph. xylosus, and Staph. simulans were the main species found in IMI in heifers. Quarters from heifers (as opposed to multiparous cows), from heifers and multiparous cows in third or fourth month in lactation (as opposed to early lactation, <60 d in milk), and with an increasing quarter milk SCC were more likely to be infected with the more relevant CNS species. Quarter milk SCC was identified as the sole statistically significant predictor for IMI with other CNS species, although the size of the effect was lower [odds ratio of 1.6 (1.4-1.9) vs. 2.1 (1.8-2.5)] than the effect for IMI with the more relevant CNS. As a strong herd effect was present, studying herd-level predictors is warranted. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

The structural and functional differentiation of hair cells in a lizard’s basilar papilla suggests an operational principle of amniote cochleas

PubMed Central

Chiappe, M. Eugenia; Kozlov, Andrei S.; Hudspeth, A. J.

2007-01-01

The hair cells in the mammalian cochlea are of two distinct types. Inner hair cells are responsible for transducing mechanical stimuli into electrical responses, which they forward to the brain through a copious afferent innervation. Outer hair cells, which are thought to mediate the active process that sensitizes and tunes the cochlea, possess a negligible afferent innervation. For every inner hair cell there are approximately three outer hair cells, so only a quarter of the hair cells directly deliver information to the central nervous system. Although this is a surprising feature for a sensory system, the occurrence of a similar innervation pattern in birds and crocodilians suggests that the arrangement has an adaptive value. Using a lizard with highly developed hearing, the tokay gecko, we demonstrate in the present study that the same principle operates in a third major group of terrestrial animals. We propose that the differentiation of hair cells into signaling and amplifying classes reflects incompatible strategies for the optimization of mechanoelectrical transduction and of an active process based on active hair-bundle motility. PMID:17978038

Infrastructure Development of Single Cell Testing Capability at A0 Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dhanaraj, Nandhini; Padilla, R.; Reid, J.

2009-09-01

The objective of this technical note is to document the details of the infrastructure development process that was realized at the A0 photo injector facility to establish RF cold testing capability for 1.3 GHz superconducting niobium single cell cavities. The activity began the last quarter of CY 2006 and ended the first quarter of CY 2009. The whole process involved addressing various aspects such as design of vertical insert and lifting fixture, modification of existing RF test station and design of new couplers, development of a Temperature Mapping (T-Map) system, radiation considerations for the test location (north cave), update ofmore » existing High Pressure Rinse (HPR) system, preparation of necessary safety documents and eventually obtaining an Operational Readiness Clearance (ORC). Figure 1 illustrates the various components of the development process. In the past, the north cave test station at A0 has supported the cold testing 3.9 GHz nine cell and single cell cavities, thus some of the components were available for use and some needed modification. The test dewar had the capacity to accommodate 1.3 GHz single cells although a new vertical insert that could handle both cavity types (1.3 and 3.9 GHz) had to be designed. The existing cryogenic system with an average capacity of {approx} 0.5 g/sec was deemed sufficient. The RF system was updated with broadband components and an additional amplifier with higher power capacity to handle higher gradients usually achieved in 1.3 GHz cavities. The initial testing phase was arbitrated to proceed with fixed power coupling. A new temperature mapping system was developed to provide the diagnostic tool for hot spot studies, quench characterization and field emission studies. The defining feature of this system was the use of diode sensors instead of the traditional carbon resistors as sensing elements. The unidirectional current carrying capacity (forward bias) of the diodes provided for the ease of multiplexing of the system, thus substantially reducing the number of cables required to power the sensors. The high gradient capacity of the 1.3 GHz cavities required a revision of the radiation shielding and interlocks. The cave was updated as per the recommendations of the radiation safety committee. The high pressure rinse system was updated with new adapters to assist the rinsing 1.3 GHz single cell cavities. Finally, a proposal for cold testing 1.3 GHz single cell cavities at A0 north cave was made to the small experiments approval committee, radiation safety committee and the Tevatron cryogenic safety sub-committee for an operational readiness clearance and the same was approved. The project was classified under research and development of single cell cavities (project 18) and was allocated a budget of $200,000 in FY 2007.« less

PV Working with Industry, 2nd Quarter, 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poole, L.; Moon, S.

2000-06-29

NREL PV Working With Industry is a quarterly newsletter devoted to the research, development, and deployment performed by NREL staff in concert with their industry and university partners. The Second Quarter, 2000, issue is titled ``Our Shared PV Future''. It contains a review of several important PV-related meetings held in the prior three months: the NCPV Program Review, the 16 European PV Conference, and year-2000 Earth Day activities in Denver, CO. The editorialist is Paul Maycock, Publisher of PV News.

Global Positioning System: Observations on Quarterly Reports from the Air Force

DTIC Science & Technology

2016-10-17

Positioning System : Observations on Quarterly Reports from the Air Force The satellite-based Global Positioning System (GPS) provides positioning, navigation...infrastructure, and transportation safety. The Department of Defense (DOD)—specifically, the Air Force—develops and operates the GPS system , which...programs, including the most recent detailed assessment of the next generation operational control system (OCX) and development of military GPS

75 FR 55356 - Proposed Collection, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... implementation process will begin with a pre-test beginning in the first quarter of 2011 to assess cell phone... burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies...

75 FR 55612 - Proposed Collection, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... implementation process will begin with a pre-test beginning in the first quarter of 2011 to assess cell phone... burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies...

Interference-induced angle-independent acoustical transparency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Lehua; Yu, Gaokun, E-mail: gkyu@ouc.edu.cn; Wang, Ning

2014-12-21

It is revealed that the Fano-like interference leads to the extraordinary acoustic transmission through a slab metamaterial of thickness much smaller than the wavelength, with each unit cell consisting of a Helmholtz resonator and a narrow subwavelength slit. More importantly, both the theoretical analysis and experimental measurement show that the angle-independent acoustical transparency can be realized by grafting a Helmholtz resonator and a quarter-wave resonator to the wall of a narrow subwavelength slit in each unit cell of a slit array. The observed phenomenon results from the interferences between the waves propagating in the slit, those re-radiated by the Helmholtzmore » resonator, and those re-radiated by the quarter-wave resonator. The proposed design may find its applications in designing angle-independent acoustical filters and controlling the phase of the transmitted waves.« less

High resolution, low cost solar cell contact development. Quarterly technical progress and schedule report, September 28, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mardesich, N.

The scope of the contract covers the development and evaluation of forming solar cell collector grid contacts by the MIDFILM process. This is a proprietary process developed by the Ferro Corporation which is a subcontractor for the program. The MIDFILM process attains line resolution characteristics of photoresist methods with processing related to screen printing. The surface to be processed is first coated with a thin layer of photoresist material. Upon exposure to ultraviolet light through a suitable mask, the resist in the non-pattern area cross-links and becomes hard. The unexposed pattern areas remain tacky. The conductor material is applied inmore » the form of a dry mixture of metal and frit particles which adhere to the tacky pattern area. The assemblage is then fired to ash the photopolymer and sinter the fritted conductor powder. Effort was concentrated during this period on the establishment, optimization and identification of problem areas of the MIDFILM process. Progress is reported. (WHK)« less

78 FR 21160 - Paperwork Reduction Act; 30-Day Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... concepts (OMB 3201-0011), pre-broadcast quantitative (or ``copy'') testing of developed advertising (OMB... Research--Focus groups; OMB 3201-0006--Copy testing--15-minute online interviews; OMB 3201-0010--Tracking...--Qualitative Research--Quarterly; OMB 3201-0006--Copy testing--Quarterly; OMB 3201-0010--Tracking Study...

Trustee Quarterly, 1991.

ERIC Educational Resources Information Center

Trustee Quarterly, 1991

1991-01-01

These four issues of "Trustee Quarterly" focus on topics of current concern to community college trustees. The winter 1991 issue contains articles examining the trustee role in helping diverse students achieve, a reconceptualization of community college finance, the development of a statewide communications plan by the Washington trustees, an…

Education Statistics Quarterly, Spring 2001.

ERIC Educational Resources Information Center

Education Statistics Quarterly, 2001

2001-01-01

The "Education Statistics Quarterly" gives a comprehensive overview of work done across all parts of the National Center for Education Statistics (NCES). Each issue contains short publications, summaries, and descriptions that cover all NCES publications, data products and funding opportunities developed over a 3-month period. Each issue…

Bovine Teat Microbiome Analysis Revealed Reduced Alpha Diversity and Significant Changes in Taxonomic Profiles in Quarters with a History of Mastitis

PubMed Central

Falentin, Hélène; Rault, Lucie; Nicolas, Aurélie; Bouchard, Damien S.; Lassalas, Jacques; Lamberton, Philippe; Aubry, Jean-Marc; Marnet, Pierre-Guy; Le Loir, Yves; Even, Sergine

2016-01-01

Mastitis is a mammary gland inflammatory disease often due to bacterial infections. Like many other infections, it used to be considered as a host-pathogen interaction driven by host and bacterial determinants. Until now, the involvement of the bovine mammary gland microbiota in the host-pathogen interaction has been poorly investigated, and mainly during the infectious episode. In this study, the bovine teat microbiome was investigated in 31 quarters corresponding to 27 animals, which were all free of inflammation at sampling time but which had different histories regarding mastitis: from no episode of mastitis on all the previous lactations (Healthy quarter, Hq) to one or several clinical mastitis events (Mastitic quarter, Mq). Several quarters whose status was unclear (possible history of subclinical mastitis) were classified as NDq. Total bacterial DNA was extracted from foremilk samples and swab samples of the teat canal. Taxonomic profiles were determined by pyrosequencing on 16s amplicons of the V3-4 region. Hq quarters showed a higher diversity compared to Mq ones (Shannon index: ~8 and 6, respectively). Clustering of the quarters based on their bacterial composition made it possible to separate Mq and Hq quarters into two separate clusters (C1 and C2, respectively). Discriminant analysis of taxonomic profiles between these clusters revealed several differences and allowed the identification of taxonomic markers in relation to mastitis history. C2 quarters were associated with a higher proportion of the Clostridia class (including genera such as Ruminococcus, Oscillospira, Roseburia, Dorea, etc.), the Bacteroidetes phylum (Prevotella, Bacteroides, Paludibacter, etc.), and the Bifidobacteriales order (Bifidobacterium), whereas C1 quarters showed a higher proportion of the Bacilli class (Staphylococcus) and Chlamydiia class. These results indicate that microbiota is altered in udders which have already developed mastitis, even far from the infectious episode. Microbiome alteration may have resulted from the infection itself and or the associated antibiotic treatment. Alternatively, differences in microbiome composition in udders with a history of mastitis may have occurred prior to the infection and even contributed to infection development. Further investigations on the dynamics of mammary gland microbiota will help to elucidate the contribution of this endogenous microbiota to the mammary gland health. PMID:27242672

Safe Gene Therapy for Type 1 Diabetes

DTIC Science & Technology

2012-10-01

by transplanting these cells, either alone or together with FoxP3+eGFP+ T-regulatory cells into prediabetic ID-TEC pups. Diabetes incidence and...transplanting these cells, either alone or together with FoxP3+eGFP+ T-regulatory cells into prediabetic ID-TEC pups. Diabetes incidence and progression will...progression of islet-autoimmunity in prediabetic ID-TEC pups. 38 In the fourth quarterly scientific progress report (06/28/11 - 09/27/11) of year 02

Surgery Branch recruiting patients to study new treatment for cancers with RAS mutations | Center for Cancer Research

Cancer.gov

RAS is a family of proteins that send signals to genes involved in cell growth and is mutated in approximately a quarter of all human cancers. James Yang, M.D., of the Surgery Branch is leading a team of investigators who have generated a special T-cell receptor from mouse cells that can recognize a mutation of RAS that is found in many human cancer cells. The goal is to

Keeping genome organized creates opportunities for damage | Center for Cancer Research

Cancer.gov

Packing an entire genome inside the cramped quarters of a cell nucleus can put chromosomes at risk for damage, according to new research led by André Nussenzweig, Ph.D., Chief of CCR’s Laboratory of Genomic Integrity. The findings, reported July 20, 2017, in Cell, suggest that DNA breaks are routinely introduced and then repaired as a cell folds and organizes its genome, and

Recirculation cells for granular flow in cylindrical rotating tumblers

NASA Astrophysics Data System (ADS)

D'Ortona, Umberto; Thomas, Nathalie; Lueptow, Richard M.

2018-05-01

To better understand the velocity field and flowing layer structure, we have performed a detailed discrete element method study of the flow of monodisperse particles in a partially filled three-dimensional cylindrical rotating tumblers. Similar to what occurs near the poles in spherical and conical tumblers, recirculation cells (secondary flows) develop near the flat endwalls of a cylindrical tumbler in which particles near the surface drift axially toward the endwall, while particles deeper in the flowing layer drift axially toward the midlength of the tumbler. Another recirculation cell with the opposite sense develops next to each endwall recirculation cell, extending to the midlength of the tumbler. For a long enough tumbler, each endwall cell is about one quarter of the tumbler diameter in length. Endwall cells are insensitive to tumbler length and relatively insensitive to rotation speed (so long as the flowing layer remains flat and continuously flowing) or fill level (from 25% to 50% full). However, for shorter tumblers (0.5 to 1.0 length/diameter aspect ratio) the endwall cell size does not change much, while center cells reduce their size and eventually disappear for the shortest tumblers. For longer tumblers (length/diameter aspect ratio larger than 2), a stagnation zone appears in between the central cells. These results provide insight into the mixing of monodisperse particles in rotating cylindrical tumblers as well as the frictional effects of the tumbler endwalls.

International oil and gas exploration and development: 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-12-01

This report starts where the previous quarterly publication ended. This first publication of a new annual series contains most of the same data as the quarterly report, plus some new material, through 1991. It also presents historical data covering a longer period of time than the previous quarterly report. Country-level data on oil reserves, oil production, active drilling rigs, seismic crews, wells drilled, oil reserve additions, and oil reserve-to-production rations (R/P ratios) are listed for about 85 countries, where available, from 1970 through 1991. World and regional summaries are given in both tabular and graphical form. The most popular tablemore » in the previous quarterly report, a listing of new discoveries, continues in this annual report as Appendix A.« less

Ideas for Medical Education: The Quarterly Profile Examination.

ERIC Educational Resources Information Center

Arnold, Louise; Willoughby, T. Lee

1990-01-01

The school of medicine of the University of Missouri--Kansas City developed the Quarterly Profile Examination, a schoolwide, longitudinal comprehensive examination of knowledge acquisition and retention, to satisfy internal and external requirements for assessment. The system is seen as effective in fostering problem-based and independent learning…

For assessment of changes in intraoperative red blood cell transfusion practices over time, the pooled incidence of transfusion correlates highly with total units transfused.

PubMed

Dexter, Franklin; Epstein, Richard H

2017-06-01

Multiple studies nationwide and at single hospitals have examined changes over time in the incidence of perioperative red blood cell (RBC) transfusion. However, the cost of RBC transfusions is related to the number of RBC units transfused, not to the incidence. We evaluate whether the readily available incidence of RBC transfusion can be used as a valid surrogate measure. Observational retrospective study. One tertiary, academic hospital. 394,789 cases of 1885 procedures over N=42 quarters of the year. None. Incidence and number of RBC units transfused intraoperatively. The number of RBC units transfused per case did not follow a Poisson distribution, confirming that the number of units and incidence of transfusion are not interchangeable for analyzing decisions by case. However, with all cases of each quarter combined, the Spearman correlation was 0.98±0.01 between each quarter's incidence of RBC transfusion and mean RBC units transfused per case (P<0.0001). For assessment of changes in intraoperative RBC transfusion practices over years, it is sufficient to analyze the pooled incidence of transfusion, rather than to calculate the number of units transfused. Copyright © 2017 Elsevier Inc. All rights reserved.

Combined Quarterly Technical Report Number 16. SATNET Development and Operation, Pluribus Satellite IMP Development, Remote Site Maintenance, Internet Development, Mobile Access Terminal Network.

DTIC Science & Technology

1980-02-01

Reserch Projects Agency I t&* ISO~p~A d m* ab~b ~I 41 b~bmso 544,A UNCLASSIFIED S@MYT SLAMIICAIGH OF TNNI PAOE tpvm Gamb.______________ RI...Wi do m,.we a#& N m WUNP SMei r -- This Quarterly Technical Report describes work on the development of and experimentation with packet broadcast by...interval by either segmenting or aggregating the stream packets such that they match the system interval. Since this approach is simple with respect

Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division, April--June 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jubin, R.T.

The Chemical and Energy Research Section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within six major areas of research: Hot Cell Operations, Process Chemistry and thermodynamics, Separations and Materials Synthesis, Solution Thermodynamics, biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.

[Prevention of intramammary infections in dairy cows by the use of a premilking teat dip method with a foaming iodophor dip agent].

PubMed

Falkenberg, U; Tenhagen, B A; Baumgärtner, B; Heuwieser, W

2002-10-01

In this study we investigated the efficacy of premilking teat dipping with a foaming iodophor teat dip in a negative controlled field study. Incidence of new intramammary infections (IMI), incidence of clinical mastitis, influence on somatic cell count (SCC) and the characteristics of udder tissue and teats were used as parameters to evaluate clinical efficacy. Predipping was compared with a negative control using a split-udder experimental design. Right teats were predipped with a foaming disinfectant containing 0.27% iodine while left teats served as controls. The latter were conventionally cleaned with damp cloth towels and dried manually with disposable paper towels ("best cleaning practice"). All teats were dipped after milking with the same dip. There were no differences between treated and control quarters with respect to incidence of new IMI during the study period (treated quarters: 6.6% vs. untreated: 6.95%), incidence of clinical mastitis (30 cases in the treatment group vs. 39 cases in the control group) and geometric mean of SCC of quarter milk samples. Spectrum of detected pathogens was also comparable. Condition of udder tissue and teat ducts did not differ between treated and control quarters.

Development of a Control System for the Teat-End Vacuum in Individual Quarter Milking Systems

PubMed Central

Ströbel, Ulrich; Rose-Meierhöfer, Sandra; Öz, Hülya; Brunsch, Reiner

2013-01-01

Progress in sensor technique and electronics has led to a decrease in the costs of electronic and sensor components. In modern dairy farms, having udders in good condition, a lower frequency of udder disease and an extended service life of dairy cows will help ensure competitiveness. The objective of this study was to develop a teat-end vacuum control system with individual quarter actor reaction. Based on a review of the literature, this system is assumed to protect the teat tissue. It reduces the mean teat-end vacuum in the maximum vacuum phase (b) to a level of 20 kPa at a flow rate of 0.25 L/min per quarter. At flow rates higher than 1.50 L/min per quarter, the teat-end vacuum can be controlled to a level of 30 kPa, because in this case it is desirable to have a higher vacuum for the transportation of the milk to the receiver. With this system it is possible for the first time to supply the teat end with low vacuum at low flow rates and with higher vacuum at increasing flow rates in a continuous process with a three second reaction-rate on individual quarter level. This system is completely automated. PMID:23765272

Applied Meteorology Unit (AMU) Quarterly Report - Fourth Quarter FY-09

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

2009-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the fourth quarter of Fiscal Year 2009 (July - September 2009). Tasks reports include: (1) Peak Wind Tool for User Launch Commit Criteria (LCC), (2) Objective Lightning Probability Tool. Phase III, (3) Peak Wind Tool for General Forecasting. Phase II, (4) Update and Maintain Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS), (5) Verify MesoNAM Performance (6) develop a Graphical User Interface to update selected parameters for the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLlT)

Reassessing Levels of Androcentric Bias in "Educational Administration Quarterly."

ERIC Educational Resources Information Center

Epp, Juanita Ross; And Others

1994-01-01

Using Shakeshaft and Hanson's criteria developed in a 1986 evaluation of androcentric bias in "Educational Administration Quarterly" articles published during the 1970s, examines articles published in "EAQ" during the 1980s. Although bias diminished in the gender of contributing authors and use of inclusive language, other less…

Gifted Education Press Quarterly, 2002.

ERIC Educational Resources Information Center

Fisher, Maurice D., Ed.

2002-01-01

These four issues of a quarterly publication for gifted educators and parents of gifted children span winter 2002 through fall 2002. Featured articles include: (1) "Cultivating Courage, Creativity, and Caring" (James T. Webb), which discusses the need to encourage the development of courage and caring, as well as creativity in gifted students; (2)…

A review of metropolitan area early deployment plans and congestion management systems for the development of intelligent transportation systems

DOT National Transportation Integrated Search

1997-01-01

The three-quarter moving composite price index is the weighted average of the indices for three consecutive quarters. The Composite Bid Price Index is composed of six indicator items: common excavation, to indicate the price trend for all roadway exc...

Cell biology of the Koji mold Aspergillus oryzae.

PubMed

Kitamoto, Katsuhiko

2015-01-01

Koji mold, Aspergillus oryzae, has been used for the production of sake, miso, and soy sauce for more than one thousand years in Japan. Due to the importance, A. oryzae has been designated as the national micro-organism of Japan (Koku-kin). A. oryzae has been intensively studied in the past century, with most investigations focusing on breeding techniques and developing methods for Koji making for sake brewing. However, the understanding of fundamental biology of A. oryzae remains relatively limited compared with the yeast Saccharomyces cerevisiae. Therefore, we have focused on studying the cell biology including live cell imaging of organelles, protein vesicular trafficking, autophagy, and Woronin body functions using the available genomic information. In this review, I describe essential findings of cell biology of A. oryzae obtained in our study for a quarter of century. Understanding of the basic biology will be critical for not its biotechnological application, but also for an understanding of the fundamental biology of other filamentous fungi.

Keeping genome organized creates opportunities for damage | Center for Cancer Research

Cancer.gov

Packing an entire genome inside the cramped quarters of a cell nucleus can put chromosomes at risk for damage, according to new research led by André Nussenzweig, Ph.D., Chief of CCR’s Laboratory of Genomic Integrity. The findings, reported July 20, 2017, in Cell, suggest that DNA breaks are routinely introduced and then repaired as a cell folds and organizes its genome, and that when repair processes fail, these breaks can give rise to chromosomal abnormalities characteristic of cancer cells. 

Study on transport infrastructure as mechanism of long-term urban planning strategies

NASA Astrophysics Data System (ADS)

Popova, Olga; Martynov, Kirill; Khusnutdinov, Rinat

2017-10-01

In this article, the authors carry out the research of the transport infrastructure. The authors have developed an algorithm for quality assessment of transport networks and connectivity of urban development areas. The results of the research are presented on the example of several central city quarters of Arkhangelsk city. The analysis was carried out by clustering objects (separate quarters of the Arkhangelsk city) using of SOM in comparable groups with a high level of similarity of characteristics inside each group. The result of clustering was 5 clusters with different levels of transport infrastructure. The novelty of the study is to justification for advantages of applying structural analysis for qualitative ranking of areas. The advantage of the proposed methodology is that it gives the opportunity both to compare the transport infrastructure quality of different city quarters and to determine the strategy for its development with a list of specific activities.

7 CFR 1703.309 - Terms of repayment of deferred loan payments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... monthly or quarterly basis depending on the existing repayment terms of the direct loan or insured loan.... The deferment payments will be made on either a monthly or quarterly basis depending on the existing... community, business, or economic development projects not included in paragraph (a) of this section, the...

Illinois Association for Counseling and Development (IACD) Quarterly, 1990.

ERIC Educational Resources Information Center

Illovsky, Michael E., Ed.

1990-01-01

This document consists of the four issues of the "IACD Quarterly" published in 1990. Articles in this volume include: (1) "A Comprehensive Program for Reducing School Anxieties in College Students" (David Ross); (2) "Issues in Child Custody Determination in Illinois" (Amy Jo Buwick); (3) "Finding Meaning in the Here and Now Through Gestalt Therapy…

Strategic Studies Quarterly. Volume 5, Number 3. Fall 2011

DTIC Science & Technology

2011-01-01

Christopher M. Hemmer, PhD Kimberly A. Hudson, PhD Col Basil S. Norris Jr., USAF, Retired Gary J. Schaub, PhD Strategic Studies Quarterly (SSQ...29). Sloterdijk goes on to describe a direct progression from the wartime use of poi­ son gas to the postwar development of pesticides and of Zyklon

Illinois Association for Counseling and Development (IACD) Quarterly, 1991.

ERIC Educational Resources Information Center

Illovsky, M., Ed.

1991-01-01

This document consists of the four issues of the "IACD Quarterly" published in 1991. Articles in the 1991 volume include: (1) "The History, Current Status and Future of Counselor Preparation in Illinois: Background and Overview" (William Gorman); (2) "Counselor Education in Illinois Prior to 1958" (John Storey); (3) "The Golden Book and Counselor…

Regional ITS architecture development : a case study : New York-New Jersey-Connecticut region : building a framework for regional ITS integration

DOT National Transportation Integrated Search

1999-01-01

The three-quarter moving composite price index is the weighted average of the indices for three consecutive quarters. The Composite Bid Price Index is composed of six indicator items: common excavation, to indicate the price trend for all roadway exc...

International Space Station USOS Crew Quarters Development

NASA Technical Reports Server (NTRS)

Broyan, James Lee, Jr.; Borrego, Melissa Ann; Bahr, Juergen F.

2008-01-01

The International Space Station (ISS) United States Operational Segment (USOS) currently provides a Temporary Sleep Station (TeSS) as crew quarters for one crewmember in the Laboratory Module. The Russian Segment provides permanent crew quarters (Kayutas) for two crewmembers in the Service Module. The TeSS provides limited electrical, communication, and ventilation functionality. A new permanent rack sized USOS ISS Crew Quarters (CQ) is being developed. Up to four CQs can be installed into the Node 2 element to increase the ISS crewmember size to six. The new CQs will provide private crewmember space with enhanced acoustic noise mitigation, integrated radiation reduction material, controllable airflow, communication equipment, redundant electrical systems, and redundant caution and warning systems. The rack sized CQ is a system with multiple crewmember restraints, adjustable lighting, controllable ventilation, and interfaces that allow each crewmember to personalize their CQ workspace. Providing an acoustically quiet and visually isolated environment, while ensuring crewmember safety, is critical for obtaining crewmember rest and comfort to enable long term crewmember performance. The numerous human factor, engineering, and program considerations during the concept, design, and prototyping are outlined in the paper.

Evaluation of selective dry cow treatment following on-farm culture: risk of postcalving intramammary infection and clinical mastitis in the subsequent lactation.

PubMed

Cameron, M; McKenna, S L; MacDonald, K A; Dohoo, I R; Roy, J P; Keefe, G P

2014-01-01

The objective of the study was to evaluate the utility of a Petrifilm-based on-farm culture system when used to make selective antimicrobial treatment decisions on low somatic cell count cows (<200,000 cells/mL) at drying off. A total of 729 cows from 16 commercial dairy herds with a low bulk tank somatic cell count (<250,000 cells/mL) were randomly assigned to receive either blanket dry cow therapy (DCT) or Petrifilm-based selective DCT. Cows belonging to the blanket DCT group were infused with a commercial dry cow antimicrobial product and an internal teat sealant (ITS) at drying off. Using composite milk samples collected on the day before drying off, cows in the selective DCT group were treated at drying off based on the results obtained by the Petrifilm on-farm culture system with DCT + ITS (Petrifilm culture positive), or ITS alone (Petrifilm culture negative). Quarters of all cows were sampled for standard laboratory bacteriology on the day before drying off, at 3 to 4d in milk (DIM), at 5 to 18 DIM, and from the first case of clinical mastitis occurring within 120 DIM. Multilevel logistic regression was used to assess the effect of study group (blanket or selective DCT) and resulting dry cow treatment (DCT + ITS, or ITS alone) on the risk of intramammary infection (IMI) at calving and the risk of a first case of clinical mastitis between calving and 120 DIM. According to univariable analysis, no difference was observed between study groups with respect to quarter-level cure risk and new IMI risk over the dry period. Likewise, the risk of IMI at calving and the risk of clinical mastitis in the first 120 DIM was not different between quarters belonging to cows in the blanket DCT group and quarters belonging to cows in the selective DCT group. The results of this study indicate that selective DCT based on results obtained by the Petrifilm on-farm culture system achieved the same level of success with respect to treatment and prevention of IMI over the dry period as blanket DCT and did not affect the risk of clinical mastitis in the first 120 d of the subsequent lactation. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Brentuximab vedotin in refractory CD30+ lymphomas: a bridge to allogeneic transplantation in approximately one quarter of patients treated on a Named Patient Programme at a single UK center

PubMed Central

Gibb, Adam; Jones, Craig; Bloor, Adrian; Kulkarni, Samar; Illidge, Tim; Linton, Kim; Radford, John

2013-01-01

The CD30-targeted agent brentuximab vedotin has shown impressive activity in relapsed/refractory Hodgkin lymphoma and anaplastic large cell lymphoma in phase II studies. We have treated 24 patients with relapsed/refratory disease enrolled onto a Named Patient Programme during 2010-11 at a single UK center. Overall response rate across all histologies was 67% (Hodgkin 72%; anaplastic large cell 60%), complete response rate 25% (Hodgkin 17%; anaplastic large cell 60%), median progression-free survival 5.1 months, and toxicity mild to moderate in the majority of cases. Six patients proceeded to allogeneic transplantation and one patient awaits this procedure. These results are similar to phase II data and show that brentuximab vedotin provides a bridge to allogeneic transplantation in approximately one quarter of patients refractory to conventional salvage therapies. Best response was seen after four doses, so consideration of allogeneic transplantation should be made early and scheduled following the first assessment indicating response. PMID:23065511

Administrative Information Systems Plan for FY89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-11-01

The Administrative Information Systems (AIS) Plan was developed to prioritize, track, and control the cost of AIS activities. This annually published plan, in conjunction with quarterly status reports, measures projected AIS activities and progress. The AIS Plan and quarterly reporting are administered jointly by the Director of Computing and an Organization 30 director. Priority development projects are clearly defined and closely managed efforts that consume significant resources. Directorate supplementals describe other AIS activity within each directorate, which may include: production support; technical support; development activity; and other AIS effort.

Innovative instructional strategy using cinema films in an undergraduate nursing course.

PubMed

Hyde, Norlyn B; Fife, Elizabeth

2005-01-01

Educators can develop innovative instructional strategies to engage students within the philosophical framework of Constructivism. To that end, the authors used films--Hollywood movies--to enhance their curriculum on neurological and psychopathological illnesses. During the fourth quarter of a seven-quarter associate degree nursing program, students developed case studies of the disorders portrayed in selected films. The authors outline the methods used to implement this approach and discuss evaluations from student and faculty perspectives.

AFRRI Reports, Fourth Quarter 1991

DTIC Science & Technology

1992-01-01

Gallin, E. K. Heat induces intracellular acidification in human A-431 cells : role of Na’-H’ exchange and metabolism. SR91-49: MacVittie, T. J., Monroy, R... induced release of DNA front agarose plugs treated with Not I restriction enzyme As above, wild-type and strain 112 cells were exposed to 2 kGy and...times. Ager and co-workers (1990) found that following irradiation of CHO-KI cells , replication forks showed reduced PFGE- induced migration out of the

76 FR 17951 - Notice of Regulatory Waiver Requests Granted for the Fourth Quarter of Calendar Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

...Section 106 of the Department of Housing and Urban Development Reform Act of 1989 (the HUD Reform Act) requires HUD to publish quarterly Federal Register notices of all regulatory waivers that HUD has approved. Each notice covers the quarterly period since the previous Federal Register notice. The purpose of this notice is to comply with the requirements of section 106 of the HUD Reform Act. This notice contains a list of regulatory waivers granted by HUD during the period beginning on October 1, 2010, and ending on December 31, 2010.

75 FR 81292 - Notice of Regulatory Waiver Requests Granted for the Third Quarter of Calendar Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

...Section 106 of the Department of Housing and Urban Development Reform Act of 1989 (the HUD Reform Act) requires HUD to publish quarterly Federal Register notices of all regulatory waivers that HUD has approved. Each notice covers the quarterly period since the previous Federal Register notice. The purpose of this notice is to comply with the requirements of section 106 of the HUD Reform Act. This notice contains a list of regulatory waivers granted by HUD during the period beginning on July 1, 2010, and ending on September 30, 2010.

77 FR 14817 - Notice of Regulatory Waiver Requests Granted for the Fourth Quarter of Calendar Year 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-13

...Section 106 of the Department of Housing and Urban Development Reform Act of 1989 (the HUD Reform Act) requires HUD to publish quarterly Federal Register notices of all regulatory waivers that HUD has approved. Each notice covers the quarterly period since the previous Federal Register notice. The purpose of this notice is to comply with the requirements of section 106 of the HUD Reform Act. This notice contains a list of regulatory waivers granted by HUD during the period beginning on October 1, 2011, and ending on December 31, 2011.

Use of a culture-independent on-farm algorithm to guide the use of selective dry-cow antibiotic therapy.

PubMed

Vasquez, A K; Nydam, D V; Foditsch, C; Wieland, M; Lynch, R; Eicker, S; Virkler, P D

2018-06-01

An algorithm using only computer-based records to guide selective dry-cow therapy was evaluated at a New York State dairy farm via a randomized field trial. DairyComp 305 (Valley Ag Software, Tulare, CA) and Dairy Herd Improvement Association test-day data were used to identify cows as low risk (cows that might not benefit from dry-cow antibiotics) or high risk (cows that will likely benefit). Low-risk cows were those that had all of the following: somatic cell count (SCC) ≤200,000 cells/mL at last test, an average SCC ≤200,000 cells/mL over the last 3 tests, no signs of clinical mastitis at dry-off, and no more than 1 clinical mastitis event in the current lactation. Low-risk cows were randomly assigned to receive intramammary antibiotics and external teat sealant (ABXTS) or external teat sealant only (TS) at dry-off. Using pre-dry-off and postcalving quarter-level culture results, low-risk quarters were assessed for microbiological cure risk and new infection risk. Groups were also assessed for differences in first-test milk yield and linear scores, individual milk weights for the first 30 d, and culling and mastitis events before 30 d in milk. A total of 304 cows and 1,040 quarters in the ABXTS group and 307 cows and 1,058 quarters in the TS group were enrolled. Among cows to be dried, the proportion of cows that met low-risk criteria was 64% (n = 611/953). Of cultures eligible for bacteriological cure analysis (n = 171), 93% of ABXTS cured, whereas 88% of TS cured. Of the non-cures, 95% were contributed by the minor pathogens coagulase-negative staphylococci (n = 19/20). These organisms also accounted for 57.5% of new infections (n = 77/134). We found no statistical differences between treatment groups for new infection risk (TS = 7.3% quarters experiencing new infections; ABXTS = 5.5%), milk production (ABXTS = 40.5 kg; TS = 41.2 kg), linear scores (ABXTS = 2.5; TS = 2.7), culling events (ABXTS, n = 18; TS, n = 15), or clinical mastitis events (ABXTS, n = 9; TS, n = 5). Results suggest that the algorithm used decreased dry-cow antibiotic use by approximately 60% without adversely affecting production or health outcomes. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Quail Egg compared to a quarter

NASA Technical Reports Server (NTRS)

2003-01-01

Quail eggs are small (shown here with a quarter for scale) and develop quickly, making them ideal for space experiments. The Avian Development Facility (ADF) supports 36 eggs in two carousels (below), one of which rotates to provide a 1-g control for comparing to eggs grown in microgravity. The ADF originated in NASA's Shuttle Student Involvement program in the 1980s and was developed under the NASA Small Business Irnovation Research program. In late 2001, the ADF made its first flight and carried eggs used in two investigations, Development and function of the inner-ear balance system in normal and altered gravity environments, and Skeletal development in embryonic quail.

Flower development in Arabidopsis: there is more to it than learning your ABCs.

PubMed

Prunet, Nathanaël; Jack, Thomas P

2014-01-01

The field of Arabidopsis flower development began in the early 1980s with the initial description of several mutants including apetala1, apetala2, and agamous that altered floral organ identity (Koornneef and van der Veen, Theor Appl Genet 58:257-263, 1980; Koornneef et al., J Hered 74:265-272, 1983). By the end of the 1980s, these mutants were receiving more focused attention to determine precisely how they affected flower development (Komaki et al., Development 104:195-203, 1988; Bowman et al., Plant Cell 1:37-52, 1989). In the last quarter century, impressive progress has been made in characterizing the gene products and molecular mechanisms that control the key events in flower development. In this review, we briefly summarize the highlights of work from the past 25 years but focus on advances in the field in the last several years.

Spatio-temporal neural stem cell behavior that leads to both perfect and imperfect structural brain regeneration in adult newts.

PubMed

Urata, Yuko; Yamashita, Wataru; Inoue, Takeshi; Agata, Kiyokazu

2018-06-14

Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural tube, whereas brain regeneration entails exquisite control of the reestablishment of certain brain parts, suggesting a yet-unknown mechanism directs NSCs upon partial brain excision. Here we report that upon one-quarter excision of the adult newt ( Pleurodeles waltl ) mesencephalon, active participation of local NSCs around specific brain subregions' boundaries leads to some imperfect and some perfect brain regeneration along an individual's rostrocaudal axis. Regeneration phenotypes depend on how the wound closing occurs using local NSCs, and perfect regeneration replicates development-like processes but takes more than one year. Our findings indicate that newt brain regeneration is supported by modularity of boundary-domain NSCs with self-organizing ability in neighboring fields. © 2018. Published by The Company of Biologists Ltd.

Augmented Reality for Close Quarters Combat

ScienceCinema

None

2018-01-16

Sandia National Laboratories has developed a state-of-the-art augmented reality training system for close-quarters combat (CQB). This system uses a wearable augmented reality system to place the user in a real environment while engaging enemy combatants in virtual space (Boston Dynamics DI-Guy). Umbra modeling and simulation environment is used to integrate and control the AR system.

EDIN-USVI Clean Energy Quarterly: Volume 1, Issue 3, September 2011 (Newsletter)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2011-09-01

This quarterly newsletter provides timely news and information about the plans and progress of the Energy Development in Island Nations-U.S. Virgin Islands pilot project, including significant events and milestones, work undertaken by each of the five working groups, and project-related renewable energy and energy efficiency educational outreach and technology deployment efforts.

How Much Does Military Spending Add to Hawaii’s Economy?

DTIC Science & Technology

2011-01-01

Development, and Tourism , Quarterly Statistical and Economic Report (QSER), 1st Quarter, 2011, 2011. As of April 20, 2011: http://hawaii.gov/dbedt...Hawaii’s economic activ- ity, but the relationship between defense jobs and employment in the state is not well under- stood. Therefore, the Hawaii Institute...14 CHAPTER FOUR Economic Modeling

Analysis of scanner data for crop inventories

NASA Technical Reports Server (NTRS)

Horvath, R. (Principal Investigator); Cicone, R. C.; Kauth, R. J.; Malila, W. A.; Pont, W.; Thelen, B.; Sellman, A.

1981-01-01

Accomplishments for a machine-oriented small grains labeler T&E, and for Argentina ground data collection are reported. Features of the small grains labeler include temporal-spectral profiles, which characterize continuous patterns of crop spectral development, and crop calendar shift estimation, which adjusts for planting date differences of fields within a crop type. Corn and soybean classification technology development for area estimation for foreign commodity production forecasting is reported. Presentations supporting quarterly project management reviews and a quarterly technical interchange meeting are also included.

Low cost hydrogen/novel membrane technology for hydrogen separation from synthesis gas, Phase 1. Quarterly technical progress report for the period ending March 31, 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-12-31

The goal of this program is to develop polymer membranes useful in the preparation of hydrogen from coal-derived synthesis gas. During this quarter the first experiment were aimed at developing high performance composite membranes for the separation of hydrogen from nitrogen and carbon monoxide. Three polymers have been selected as materials for these membranes: polyetherimide cellulose acetate and ethylcellulose. This quarter the investigators worked on polyetherimide and cellulose acetate membranes. The overall structure of these membranes is shown schematically in Figure 1. As shown, a microporous support membrane is first coated with a high flux intermediate layer then with anmore » ultrathin permselective layer and finally, if necessary, a thin protective high flux layer. 1 fig., 4 tabs.« less

Development and operation of a quality assurance system for deviations from standard operating procedures in a clinical cell therapy laboratory.

PubMed

McKenna, D; Kadidlo, D; Sumstad, D; McCullough, J

2003-01-01

Errors and accidents, or deviations from standard operating procedures, other policy, or regulations must be documented and reviewed, with corrective actions taken to assure quality performance in a cellular therapy laboratory. Though expectations and guidance for deviation management exist, a description of the framework for the development of such a program is lacking in the literature. Here we describe our deviation management program, which uses a Microsoft Access database and Microsoft Excel to analyze deviations and notable events, facilitating quality assurance (QA) functions and ongoing process improvement. Data is stored in a Microsoft Access database with an assignment to one of six deviation type categories. Deviation events are evaluated for potential impact on patient and product, and impact scores for each are determined using a 0- 4 grading scale. An immediate investigation occurs, and corrective actions are taken to prevent future similar events from taking place. Additionally, deviation data is collectively analyzed on a quarterly basis using Microsoft Excel, to identify recurring events or developing trends. Between January 1, 2001 and December 31, 2001 over 2500 products were processed at our laboratory. During this time period, 335 deviations and notable events occurred, affecting 385 products and/or patients. Deviations within the 'technical error' category were most common (37%). Thirteen percent of deviations had a patient and/or a product impact score > or = 2, a score indicating, at a minimum, potentially affected patient outcome or moderate effect upon product quality. Real-time analysis and quarterly review of deviations using our deviation management program allows for identification and correction of deviations. Monitoring of deviation trends allows for process improvement and overall successful functioning of the QA program in the cell therapy laboratory. Our deviation management program could serve as a model for other laboratories in need of such a program.

Effects of Impurities and Processing on Silicon Solar Cells, Phase 3

NASA Technical Reports Server (NTRS)

Hopkins, R. H.; Davis, J. R.; Blais, P. D.; Rohatgi, A.; Campbell, R. B.; Rai-Choudhury, P.; Stapleton, R. E.; Mollenkopf, H. C.; Mccormick, J. R.

1979-01-01

Results of the 14th quarterly report are presented for a program designed to assess the effects of impurities, thermochemical processes and any impurity process interactions on the performance of terrestrial silicon solar cells. The Phase 3 effort encompasses: (1) potential interactions between impurities and thermochemical processing of silicon; (2) impurity-cell performance relationships in n-base silicon; (3) effect of contaminants introduced during silicon production, refining or crystal growth on cell performance; (4) effects of nonuniform impurity distributions in large area silicon wafers; and (5) a preliminary study of the permanence of impurity effects in silicon solar cells.

Quarterly Performance/Technical Report of the National Marrow Donor Program

DTIC Science & Technology

2011-01-28

emergency notification system, the NMDP public announcement system, Government Emergency Telecommunications Service calling cards (GETS cards ), and the...Contract Audit Agency RCC Renal Cell Carcinoma DIY Do it yourself RCI BMT Resource for Clinical Investigations in Blood and Marrow Transplantation

Urban Planning Aspects of Museum Quarters as an Architectural Medium for Creative Cities

NASA Astrophysics Data System (ADS)

Kochergina, Ekaterina

2017-10-01

Since the second half of the 20th century, urban environment has experienced significant transformation. Splash of interactivity, bottom-up initiations with development of creative sector of city economy and participatory planning, irretrievably changed the attitude to the urban medium. One of the most intensively growing field - creative industry - provided cities with numerous cultural clusters, which boosted urban economic development and social cohesion. Supported in many cases by gentrification and revitalization, these processes brought renovation of brownfield and more comprehensive approaches to urban design. Understanding of the economic benefits made city managers start an active promotion of creative clusters and their intensive integration into urban life, involving the main museums and cultural institutions. Thus, a new type of cultural clusters - Museum Quarter - appeared. Holding the position of cultural flagman in the historical heart of the city, Museum Quarters (MQs) pretend to take on an important role both in urban planning structure and in social life. Furthermore, such role usually has strong influence on the surrounding districts, in a positive or negative way. Although basic principles are still applied for all types of cultural districts, the phenomena of “Museum Quarters” due to the complexity of planning, operating and maintenance issues, stepped far above basic cultural clusters, requiring substantially new attitude to the planning of such urban entities. Five clusters were chosen for this study: MQs in Vienna, Berlin, Amsterdam, Copenhagen and the currently developing project in Budapest. The main purpose of this paper is to elaborate the principles for the practical implementation of Museum Quarters by the definition and classification of their specific urban planning aspects. The complexity of target object - Museum Quarter - and its multi-level relationships with the whole city, require from the research interdisciplinary approach and methodology of systemic-structural analysis. The typology of different MQs - identifying specific and common features - is based on studies of urban grids and architectural characters. The critical observation and comparison of the sociopolitical background and the traditional and modern understanding of museum environment helped to define some crucial misconceptions in interpretation, such as the widespread attitude to the Museum Quarter as a museum building, not as a part of urban medium, causing documented obstacles to development. Consideration of drawbacks and advantages, as the results of this study, showed potential of Museum Quarters as new models of urban environment for smart-governed, economically and socially sustainable contemporary city life.

Technology evaluation: VEGF165 gene therapy, Valentis Inc.

PubMed

Morse, M A

2001-02-01

Valentis Inc, formerly GeneMedicine, is developing a vascular endothelial growth factor (VEGF165) non-viral gene therapy using its proprietary PINC polymer for plasmid condensation. Two physician-initiated phase II angioplasty trials are ongoing, one for treating peripheral vascular disease and one for treating coronary artery disease [281714], [347153]. In February 2000, the trials were expected to be completed in the fourth quarter of 2000 [356225]; however, in October 2000, it was reported that the trial for peripheral vascular disease would be completed in the first quarter of 2001 [385232]. In March 2000, Valentis initiated a trial incorporating Valentis's DOTMA-based cationic lipid gene delivery system and the VEGF165 gene with Eurogene's local collar-reservoir delivery device. The trial is designed to demonstrate that the VEGF165 gene, delivered locally to the outside surface of a blood vessel, will transfect and express in the smooth muscle cells of the vessel wall [360683]. In March 1999, Valentis was awarded with a Phase II SBIR grant of $686,260. The aim of grant was to advance the development of non-viral gene therapies for ischemia. Specifically, Valentis intended to select an optimal promoter to be used with the VEGF expression plasmid. Valentis also intended to evaluate the gene therapy system in a rabbit ischemia model and complete the necessary preclinical studies for submission of an IND [318137].

Normal milk microbiome is reestablished following experimental infection with Escherichia coli independent of intramammary antibiotic treatment with a third-generation cephalosporin in bovines.

PubMed

Ganda, Erika K; Gaeta, Natalia; Sipka, Anja; Pomeroy, Brianna; Oikonomou, Georgios; Schukken, Ynte H; Bicalho, Rodrigo C

2017-07-12

The use of antimicrobials in food animals and the emergence of antimicrobial resistance are global concerns. Ceftiofur is the only third-generation cephalosporin labeled for veterinary use in the USA, and it is the drug of choice in the majority of dairy farms for the treatment of mastitis. Here, we use next-generation sequencing to describe longitudinal changes that occur in the milk microbiome before, during, and after infection and treatment with ceftiofur. Twelve animals were intramammary challenged with Escherichia coli in one quarter and randomly allocated to receive intramammary treatment with ceftiofur (5d) or untreated controls. Serial samples were collected from -72 to 216 h relative to challenge from the challenged quarter, an ipsilateral quarter assigned to the same treatment group, and from a third quarter that did not undergo intervention. Infection with E. coli dramatically impacted microbial diversity. Ceftiofur significantly decreased LogCFUs but had no significant effect on the milk microbiome, rate of pathogen clearance, or somatic cell count. At the end of the study, the microbial profile of infected quarters was indistinguishable from pre-challenge samples in both treated and untreated animals. Intramammary infusion with ceftiofur did not alter the healthy milk (i.e., milk devoid of clots or serous appearance and collected from a mammary gland that shows no clinical signs of mastitis) microbiome. Our results indicate that the mammary gland harbors a resilient microbiome, capable of reestablishing itself after experimental infection with E. coli independent of antimicrobial treatment.

Plant allometry, leaf nitrogen and phosphorus stoichiometry, and interspecific trends in annual growth rates.

PubMed

Niklas, Karl J

2006-02-01

Life forms as diverse as unicellular algae, zooplankton, vascular plants, and mammals appear to obey quarter-power scaling rules. Among the most famous of these rules is Kleiber's (i.e. basal metabolic rates scale as the three-quarters power of body mass), which has a botanical analogue (i.e. annual plant growth rates scale as the three-quarters power of total body mass). Numerous theories have tried to explain why these rules exist, but each has been heavily criticized either on conceptual or empirical grounds. N,P-STOICHIOMETRY: Recent models predicting growth rates on the basis of how total cell, tissue, or organism nitrogen and phosphorus are allocated, respectively, to protein and rRNA contents may provide the answer, particularly in light of the observation that annual plant growth rates scale linearly with respect to standing leaf mass and that total leaf mass scales isometrically with respect to nitrogen but as the three-quarters power of leaf phosphorus. For example, when these relationships are juxtaposed with other allometric trends, a simple N,P-stoichiometric model successfully predicts the relative growth rates of 131 diverse C3 and C4 species. The melding of allometric and N,P-stoichiometric theoretical insights provides a robust modelling approach that conceptually links the subcellular 'machinery' of protein/ribosomal metabolism to observed growth rates of uni- and multicellular organisms. Because the operation of this 'machinery' is basic to the biology of all life forms, its allometry may provide a mechanistic explanation for the apparent ubiquity of quarter-power scaling rules.

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland.

PubMed

Mitterhuemer, Simone; Petzl, Wolfram; Krebs, Stefan; Mehne, Daniel; Klanner, Andrea; Wolf, Eckhard; Zerbe, Holm; Blum, Helmut

2010-02-25

Coliform bacteria are the most common etiologic agents in severe mastitis of cows. Escherichia coli infections are mostly restricted to a single udder quarter whereas neighboring quarters stay clinically inapparent, implicating the presence of a systemic defense reaction. To address its underlying mechanism, we performed a transcriptome study of mammary tissue from udder quarters inoculated with E. coli (6 h and 24 h post infection), from neighboring quarters of the same animals, and from untreated control animals. After 6 h 13 probe sets of differentially expressed genes (DEG) were detected in infected quarters versus control animals. Eighteen hours later 2154 and 476 DEG were found in infected and in neighboring quarters vs. control animals. Cluster analysis revealed DEG found only in infected quarters (local response) and DEG detected in both infected and neighboring quarters (systemic response). The first group includes genes mainly involved in immune response and inflammation, while the systemic reaction comprises antigen processing and presentation, cytokines, protein degradation and apoptosis. Enhanced expression of antimicrobial genes (S100A8, S100A9, S100A12, CXCL2, GNLY), acute phase genes (LBP, SAA3, CP, BF, C6, C4BPA, IF), and indicators of oxidative stress (GPX3, MT1A, MT2A, SOD2) point to an active defense reaction in infected and neighboring healthy quarters. Its early onset is indicated by increased transcription of NFIL3 at 6 h. NFIL3 is a predicted regulator of many genes of the systemic response at 24 h. The significance of our transcriptome study was evidenced by some recent findings with candidate gene based approaches. The discovery and holistic analysis of an extensive systemic reaction in the mammary gland significantly expands the knowledge of host-pathogen interactions in mastitis which may be relevant for the development of novel therapies and for genetic selection towards mastitis resistance.

Disability self-assessment and upper quarter muscle balance between female dental hygienists and non-dental hygienists.

PubMed

Johnson, Eric G; Godges, Joseph J; Lohman, Everett B; Stephens, Joni A; Zimmerman, Grenith J; Anderson, Sharon P

2003-01-01

The purpose of this pilot study was to compare disability self-assessment and upper quarter muscle balance female dental hygienists and non dental hygienist females. The upper quarter was operationally defined as the shoulder and neck region. Muscle balance was operationally defined as muscle flexibility and muscle performance. A convenience sample of 41 working dental hygienists and 46 non dental hygienists participated in the study. Muscle flexibility of the upper quarter was measured by inclinometry or standard muscle length testing. Muscle performance was measured by timing the duration of four statically maintained positions. Subjects filled out the Northwick Park Neck Pain Questionnaire (NPNPQ), which is a disability self-assessment. Analysis of Covariance (ANCOVA) was used during data analysis to adjust for the mean age difference between the dental hygienist group (38.0 years) and the non-dental hygienist group (29.3 years). The results of this pilot study suggest that female dental hygienists are more likely than non dental hygienist females to develop tightness in the upper trapezius (p = 0.007) and the levator scapula (p = 0.01) of the non dominant upper quarter and lower fibers of the pectoralis major of the dominant upper quarter (p = 0.03) Muscle performance trends in the dental hygienist group supported muscle balance theory that short muscles remain strong while lengthened muscles become weak. The dental hygienist group had higher disability scores in all nine parts of the NPNPQ compared to the non-dental hygienist group, five of which were statistically significant (p < 0.05). The results of this pilot study suggest that muscle imbalances in the upper quarter are more common in female dental hygienists than in female non dental hygienists and may contribute to the numerous upper quarter pathologies associated with the practice of dental hygiene. Further research is needed to determine if upper quarter strengthening and flexibility exercises performed by dental hygienists can reduce disability self-assessment.

FUEL-FLEXIBLE GASIFICATION-COMBUSTION TECHNOLOGY FOR PRODUCTION OF H2 AND SEQUESTRATION-READY CO2

DOE Office of Scientific and Technical Information (OSTI.GOV)

George Rizeq; Janice West; Arnaldo Frydman

Further development of a combustion Large Eddy Simulation (LES) code for the design of advanced gaseous combustion systems is described in this sixth quarterly report. CFD Research Corporation (CFDRC) is developing the LES module within the parallel, unstructured solver included in the commercial CFD-ACE+ software. In this quarter, in-situ adaptive tabulation (ISAT) for efficient chemical rate storage and retrieval was implemented and tested within the Linear Eddy Model (LEM). ISAT type 3 is being tested so that extrapolation can be performed and further improve the retrieval rate. Further testing of the LEM for subgrid chemistry was performed for parallel applicationsmore » and for multi-step chemistry. Validation of the software on backstep and bluff-body reacting cases were performed. Initial calculations of the SimVal experiment at Georgia Tech using their LES code were performed. Georgia Tech continues the effort to parameterize the LEM over composition space so that a neural net can be used efficiently in the combustion LES code. A new and improved Artificial Neural Network (ANN), with log-transformed output, for the 1-step chemistry was implemented in CFDRC's LES code and gave reasonable results. This quarter, the 2nd consortium meeting was held at CFDRC. Next quarter, LES software development and testing will continue. Alpha testing of the code will continue to be performed on cases of interest to the industrial consortium. Optimization of subgrid models will be pursued, particularly with the ISAT approach. Also next quarter, the demonstration of the neural net approach, for multi-step chemical kinetics speed-up in CFD-ACE+, will be accomplished.« less

[Capacity Building for Prevention and Health Promotion for Children and Parents in a Deprived Urban Quarter: Lenzgesund].

PubMed

Süß, W; Nickel, S; Wolf, K; Trojan, A

2015-09-01

In 2005 the local health authority Hamburg-Eimsbüttel developed a prevention programme for the disadvantaged quarter "Lenzsiedlung" which has been implemented by the stakeholders committee "Round Table Lenzgesund" and other partners led by the health authority. The Department of Medical Sociology and Health Economics of the University Medical Centre had taken on the accompanying analysis and long-term evaluation with a mixture of qualitative and quantitative methods for health reporting and evaluation and a new instrument for measuring capacity building in the quarter (KEQ). © Georg Thieme Verlag KG Stuttgart · New York.

ENHANCED PRACTICAL PHOTOSYNTHETIC CO2 MITIGATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dr. Gregory Kremer; Dr. David J. Bayless; Dr. Morgan Vis

2001-07-25

This quarterly report documents significant achievements in the Enhanced Practical Photosynthetic CO{sub 2} Mitigation project during the period from 4/03/2001 through 7/02/2001. Most of the achievements are milestones in our efforts to complete the tasks and subtasks that constitute the project objectives. Note that this version of the quarterly technical report is a revision to add the reports from subcontractors Montana State and Oak Ridge National Laboratories The significant accomplishments for this quarter include: Development of an experimental plan and initiation of experiments to create a calibration curve that correlates algal chlorophyll levels with carbon levels (to simplify future experimentalmore » procedures); Completion of debugging of the slug flow reactor system, and development of a plan for testing the pressure drop of the slug flow reactor; Design and development of a new bioreactor screen design which integrates the nutrient delivery drip system and the harvesting system; Development of an experimental setup for testing the new integrated drip system/harvesting system; Completion of model-scale bioreactor tests examining the effects of CO{sub 2} concentration levels and lighting levels on Nostoc 86-3 growth rates; Completion of the construction of a larger model-scale bioreactor to improve and expand testing capabilities and initiation of tests; Substantial progress on construction of a pilot-scale bioreactor; and Preliminary economic analysis of photobioreactor deployment. Plans for next quarter's work are included in the conclusions. A preliminary economic analysis is included as an appendix.« less

Counselor's Information Service: A Quarterly Annotated Bibliography of Current Literature on Educational and Vocational Guidance. Volume 30, Number 4, December 1975.

ERIC Educational Resources Information Center

B'nai B'rith, Washington, DC. Career and Counseling Services.

This publication is a quarterly annotated bibliography of current literature on educational and vocational guidance, and is developed by the B'nai B'rith Career and Counseling Services, Washington, D.C. The topics covered are occupational information, educational, vocational and personal guidance; guidance administration and procedures; student…

Project LIFE--Language Improvement to Facilitate Education. (Technical Progress Report; Third Quarter; March 1, 1974-May 31, 1974).

ERIC Educational Resources Information Center

National Foundation for the Improvement of Education, Washington, DC.

Reported is the third quarter, fiscal year 1974 (March 1, 1974-May 31, 1974) technical progress of Project LIFE (Language Improvement to Facilitate Education), toward developing an instructional system in which filmstrips in the areas of perceptual training, perceptual thinking, and language/reading are used to assist hearing impaired children in…

Imaging Single Cells in the Living Retina

PubMed Central

Williams, David R.

2011-01-01

A quarter century ago, we were limited to a macroscopic view of the retina inside the living eye. Since then, new imaging technologies, including confocal scanning laser ophthalmoscopy, optical coherence tomography, and adaptive optics fundus imaging, transformed the eye into a microscope in which individual cells can now be resolved noninvasively. These technologies have enabled a wide range of studies of the retina that were previously impossible. PMID:21596053

AFRRI Reports Third Quarter, July - September 1991

DTIC Science & Technology

1991-10-01

provide useful phenotypic markers for the different (36). Only one t pe of outwvard voltage-dependent K con- cell types. In vivo T-cell activation is...Graftitng its [ie In A. Bjorklund and U. Stent% tLds .). NVeural Grafting tin t/e Alaminulian CXVS. Elsevier, Amsterdam. 1985. pp. 41-49. Malinmalian LN.S...factor traceable to the National Institute of transormaion.Standards and Trechnology (29). The dosimetry measurements were per- oncogene-induced

Emerging materials for solar cell applications: electrodeposited CdTe. Second quarter report, May 16-August 15, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basol, B.; Stafsudd, O.

1980-09-10

Work was centered about improving electroplating processes and cell fabrication techniques, with emphasis being given to three differing n-CdTe/Au Schottky configurations. The highest values of efficiency-related parmeters achieved with a simulated solar irradiation of 100 mW/cm/sup 2/ were 0.57V for open circuit voltage, 0.6 for fill factor, and 6 mA/cm/sup 2/ for short circuit current. Four important parameters are known to control the quality of the Monosolar electrodeposition process and resultant solar cells. They are electrolyte temperature, Te concentration in the solution at a specific pH, deposition or quasi-rest potential, and flow pattern of the electrolyte (stirring). The first threemore » considerations are believed to be fully understood and optimized. Work is underway to further understand the effects of stirring on the diffusion of ionic components and the effects on CdTe film performance. Work was accelerated during the quarter to increase the short circuit current. Parallel programs using laser irradiation of finished CdTe films, heat treatment, and changes in the electrodeposition process itself to recrystallize films were started. The surface etching technique has been highly refined, while the entire cell manufacturing process is now reproducible when defect-free substrates are used.« less

Genetic relatedness and virulence factors of bovine Staphylococcus aureus isolated from teat skin and milk.

PubMed

da Costa, L B; Rajala-Schultz, P J; Hoet, A; Seo, K S; Fogt, K; Moon, B S

2014-11-01

The objective of this study was to assess the role of teat skin colonization in Staphylococcus aureus intramammary infections (IMI) by evaluating genetic relatedness of Staph. aureus isolates from milk and teat skin of dairy cows using pulsed-field gel electrophoresis and characterizing the isolates based on the carriage of virulence genes. Cows in 4 known Staph. aureus-positive herds were sampled and Staph. aureus was detected in 43 quarters of 20 cows, with 10 quarters positive in both milk and skin (20 isolates), 18 positive only in milk, and 15 only on teat skin. Quarters with teat skin colonized with Staph. aureus were 4.5 times more likely to be diagnosed with Staph. aureus IMI than quarters not colonized on teat skin. Three main clusters were identified by pulsed-field gel electrophoresis using a cutoff of 80% similarity. All 3 clusters included both milk and skin isolates. The majority of isolates (72%) belonged to one predominant cluster (B), with 60% of isolates in the cluster originating from milk and 40% from teat skin. Genotypic variability was observed within 10 pairs (formed by isolates originating from milk and teat skin of the same quarter), where isolates in 5 out of the 10 pairs belonged to the same cluster. Forty-two virulence factors were screened using PCR. Some virulence factors were carried more frequently by teat skin isolates than by milk isolates or isolates from quarters with high somatic cell counts. Isolates in the predominant cluster B carried virulence factors clfA and clfB significantly more often than isolates in the minor clusters, which may have assisted them in becoming predominant in the herds. The present findings suggest that teat skin colonization with Staph. aureus can be an important factor involved in Staph. aureus IMI. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Impact of intramammary tilmicosin infusion as a dry cow therapy.

PubMed

Mohammadsadegh, M

2018-02-01

Three hundred subclinically infected quarters of 259 Holstein cows infected with gram-positive bacteria were selected via quota sampling based on the California Mastitis Test (CMT) result and were divided randomly and equally into treatment and test groups. Quarters of test group (n = 150 in 128 cows) were treated with an intramammary infusion of tilmicosin, and quarters of the control group (n = 150 in 131 cows) were treated with cloxacillin as a traditional intramammary infusion of dry cow (DC) ointment. Cows with more than one infected quarter were randomly assigned to the same group, and adjacent quarters were treated the same. The milk samples of all quarters were obtained, and bacterial cultures and somatic cell count (SCC) were tested before dry cow therapy (DCT) (50 ± 15 days before parturition), and finally on day 2 of the next lactation. Results have shown that total bacteriological cure rates on day 2 of the next lactation were 45% and 78%, (p = .01), new infection rates were 43.3% and 56.6%, and SCC was (6.732 × 10 5  ± 3.124 × 10 5 ) and (5.025 × 10 5  ± 2.935 × 10 5 ), (p > .05) in test and control groups, respectively. Tilmicosin had less effect on reducing IMI due to Corynebacterium bovis, and had no effect on Streptococcus agalactiae, but had a potent effect against Staphylococcus aureus. It was concluded that tilmicosin alone should not be infused as an alternative to conventional dry cow therapy. However, it had a significant effect against S. aureus, and the potential of tilmicosin to treat S. aureus IMI should be confirmed in further studies. © 2017 John Wiley & Sons Ltd.

Adherence and efficacy of an external teat sealant to prevent new intramammary infections in the dry period.

PubMed

Lim, G H; Leslie, K E; Kelton, D F; Duffield, T F; Timms, L L; Dingwell, R T

2007-03-01

The efficacy and adherence of an external teat sealant applied at drying off was evaluated in 2 studies between 1997 and 1999. At drying off, 2 quarters were randomized to receive intramammary dry-cow antibiotic therapy, and the remaining 2 quarters were treated with either a single or double application of external teat sealant. Approximately 3 d before calving, all teats that had been dipped at drying off were redipped in a single coating of teat sealant. Adherence of the teat sealant was scored for the first 2 wk after drying off, and physical traits of the teat skin and teat ends were recorded. Quarter milk samples were collected 1 wk before drying off, at drying off, 0 to 7 d, and 14 to 21 d postcalving. Somatic cell counts were determined from quarter samples taken at d 7 and 14 to 21 d after calving. Data were analyzed from 172 dry periods of 162 cows. The mean time of sealant adherence following drying off application was 3 +/- 0.13 d. Double sealant application significantly increased the duration of adherence by 0.67 d. Teats that had teat sealant applied twice at drying off and that had up to 3 d of adherence had the lowest linear score (LS) at 14 to 21 d (1.89 +/- 0.31) of all quarters. The LS of quarters that received antibiotic therapy only was 2.27 +/- 0.19. The majority of intramammary infections identified at drying off were caused by the minor pathogens, coagulase-negative staphylococci and Corynebacterium bovis (51 and 23%, respectively). The results from this study indicate that duration of sealant adherence to the teat-end should be considered when evaluating the impact of teat sealant treatment at drying off on the level of infection after calving. Double sealant application, cooler seasons, and longer teat lengths were associated with a significant increase in the duration of sealant adherence to the teat-end.

Investigation of body and udder skin surface temperature differentials as an early indicator of mastitis in Holstein Friesian crossbred cows using digital infrared thermography technique

PubMed Central

Sathiyabarathi, M.; Jeyakumar, S.; Manimaran, A.; Pushpadass, Heartwin A.; Sivaram, M.; Ramesha, K. P.; Das, D. N.; Kataktalware, Mukund A.; Jayaprakash, G.; Patbandha, Tapas Kumar

2016-01-01

Aim: The objective of this study was to investigate the ability of infrared thermography (IRT) technique and its interrelationship with conventional mastitis indicators for the early detection of mastitis in Holstein Friesian (HF) crossbred cows. Materials and Methods: A total of 76 quarters of lactating HF crossbred (Bos indicus × Bos taurus) cows (n=19) were monitored for body temperature (i.e., eye temperature) and udder skin surface temperature (USST) before milking using forward-looking infrared (FLIR) i5 camera. Milk samples were collected from each quarter and screened for mastitis using Somatic Cell Count (SCC), Electrical Conductivity (EC), and California mastitis test. Thermographic images were analyzed using FLIR Quick Report 1.2 image analysis software. Data on body and USST were compiled and analyzed statistically using SPSS 16.0 and Sigmaplot 11. Results: The mean±standard deviation (SD) body (37.23±0.08°C) and USST (37.22±0.04°C) of non-mastitic cow did not differ significantly; however, the mean USST of the mastitis-affected quarters were significantly higher than the body temperature and USST of unaffected quarters (p<0.001). The mean±SD USST of the subclinical mastitis (SCM) and clinical mastitis-affected quarters were 38.08±0.17 °C and 38.25±0.33 °C, respectively, which is 0.72 and 1.05 °C higher than the USST temperature of unaffected quarters. The USST was positively correlated with EC (r=0.95) and SCC (r=0.93). The receiver operating characteristic curve analysis revealed a higher sensitivity for USST in early prediction of SCM with a cut-off value of >37.61°C. Conclusion: It is concluded that infrared thermal imaging technique could be used as a potential noninvasive, quick cow-side diagnostic technique for screening and early detection of SCM and clinical mastitis in crossbred cows. PMID:28096610

Scientific reasoning skills development in the introductory biology courses for undergraduates

NASA Astrophysics Data System (ADS)

Schen, Melissa S.

Scientific reasoning is a skill of critical importance to those students who seek to become professional scientists. Yet, there is little research on the development of such reasoning in science majors. In addition, scientific reasoning is often investigated as two separate entities: hypothetico-deductive reasoning and argumentation, even though these skills may be linked. With regard to argumentation, most investigations look at its use in discussing socioscientific issues, not in analyzing scientific data. As scientists often use the same argumentation skills to develop and support conclusions, this avenue needs to be investigated. This study seeks to address these issues and establish a baseline of both hypothetico-deductive reasoning and argumentation of scientific data of biology majors through their engagement in introductory biology coursework. This descriptive study investigated the development of undergraduates' scientific reasoning skills by assessing them multiple times throughout a two-quarter introductory biology course sequence for majors. Participants were assessed at the beginning of the first quarter, end of the first quarter, and end of the second quarter. A split-half version of the revised Lawson Classroom Test of Scientific Reasoning (LCTSR) and a paper and pencil argumentation instrument developed for this study were utilized to assess student hypothetico-deductive reasoning and argumentation skills, respectively. To identify factors that may influence scientific reasoning development, demographic information regarding age, gender, science coursework completed, and future plans was collected. Evidence for course emphasis on scientific reasoning was found in lecture notes, assignments, and laboratory exercises. This study did not find any trends of improvement in the students' hypothetico-deductive reasoning or argumentation skills either during the first quarter or over both quarters. Specific difficulties in the control of variables and direct hypothetico-deductive reasoning were found through analysis of the LCTSR data. Students were also found to have trouble identifying and rebutting counterarguments, compared to generating initial arguments from scientific data sets. Although no overall improvement was found, a moderate, positive relationship was detected between LCTSR and argumentation scores at each administration, affirming the predicted association. Lastly, no difference was determined between biology majors and other students also enrolled in the courses. Overall, the results found here are similar to those classified in the literature for both hypothetico-deductive reasoning and argumentation, indicating that biology majors may be similar to other populations studied. Also, as no explicit attention was paid to scientific reasoning skills in the two courses, these findings complement those that illustrate a need for direct attention to foster the development of these skills. These results suggest the need to develop direct and explicit methods in order to improve the scientific reasoning skills of future biological scientists early in their undergraduate years.

Intermediate temperature solid oxide fuel cell based on lanthanum gallate electrolyte

NASA Astrophysics Data System (ADS)

Inagaki, Toru; Nishiwaki, Futoshi; Yamasaki, Satoru; Akbay, Taner; Hosoi, Kei

The Kansai Electric Power Co. Inc. (KEPCO) and Mitsubishi Materials Corporation (MMC) have been developing intermediate temperature solid oxide fuel cells (IT-SOFCs) which are operable at a temperature range between 600 and 800 °C. There are some significant features in IT-SOFC of KEPCO-MMC: (1) highly conductive lanthanum gallate-based oxide is adopted as an electrolyte to realize high-performance disk-type electrolyte-supported cells; (2) the cell-stacks with seal-less structure using metallic separators allow residual fuel to burn around the stack and the combustion heat is utilized for thermally self-sustainable operation; (3) the separators have flexible arms by which separate compressive forces can be applied for manifold parts and interconnection parts. We are currently participating in the project by New Energy and Industrial Technology Development Organization (NEDO) to develop 10 kW-class combined heat and power (CHP) systems. In FY2006, a 10 kW-class module was developed, with which the electrical efficiency of 50%HHV was obtained based on DC 12.6 kW. In the first quarter of FY2007, the 10 kW-class CHP system using the module gave the electrical efficiency of 41%HHV on AC 10 kW and the overall efficiency of 82%HHV when exhaust heat was recovered as 60 °C hot water. Currently, the operation has been accumulated for about 2500 h to evaluate the long-term stability of the system.

Online Learning Flight Control for Intelligent Flight Control Systems (IFCS)

NASA Technical Reports Server (NTRS)

Niewoehner, Kevin R.; Carter, John (Technical Monitor)

2001-01-01

The research accomplishments for the cooperative agreement 'Online Learning Flight Control for Intelligent Flight Control Systems (IFCS)' include the following: (1) previous IFC program data collection and analysis; (2) IFC program support site (configured IFC systems support network, configured Tornado/VxWorks OS development system, made Configuration and Documentation Management Systems Internet accessible); (3) Airborne Research Test Systems (ARTS) II Hardware (developed hardware requirements specification, developing environmental testing requirements, hardware design, and hardware design development); (4) ARTS II software development laboratory unit (procurement of lab style hardware, configured lab style hardware, and designed interface module equivalent to ARTS II faceplate); (5) program support documentation (developed software development plan, configuration management plan, and software verification and validation plan); (6) LWR algorithm analysis (performed timing and profiling on algorithm); (7) pre-trained neural network analysis; (8) Dynamic Cell Structures (DCS) Neural Network Analysis (performing timing and profiling on algorithm); and (9) conducted technical interchange and quarterly meetings to define IFC research goals.

Heifers infected with coagulase-negative staphylococci in early lactation have fewer cases of clinical mastitis and higher milk production in their first lactation than noninfected heifers.

PubMed

Piepers, S; Opsomer, G; Barkema, H W; de Kruif, A; De Vliegher, S

2010-05-01

Intramammary infections (IMI) in recently calved dairy heifers are more common than was formerly believed but their relevance for future performance has been studied only rarely. In the present study, the association between the IMI status of fresh heifers and their subsequent udder health, milk production, and culling in first lactation was explored. Quarter milk samples were collected between 1 and 4 d in milk (DIM) and between 5 and 8 DIM from 191 dairy heifers in 20 dairy herds for bacteriological culturing and somatic cell count (SCC) analysis. Monthly milk recording data including composite milk SCC and test-day milk yield (MY) were obtained for the first 285 DIM or until culling. Farmer-recorded clinical mastitis cases were available. Data were analyzed using mixed models and survival analysis. Approximately 80% of the fresh heifers (79.8%) had at least one culture-positive quarter. Coagulase-negative staphylococci (CNS) were the most frequently isolated pathogens (72%), followed by esculin-positive streptococci (4.6%) and Staphylococcus aureus (3.5%). Overall geometric mean SCC at quarter level decreased between the first and second samplings from 348,000 to 116,000 cells/mL. Heifers infected with CNS had an intermediate average test-day SCC (84,000 cells/mL) during the first 285 DIM compared with noninfected heifers (53,000 cells/mL) and heifers infected with major pathogens (195,000 cells/mL). Heifers infected with major pathogens had a much lower average daily MY (18.3kg) during first lactation compared with noninfected animals (21.3kg). That CNS-infected heifers out-produced their noninfected counterparts could be at least partially explained by their significantly lower incidence of clinical mastitis (incidence risk 3.6 vs. 21.0%) during first lactation compared with noninfected heifers. We conclude that although CNS cause the majority of IMI in heifers around calving, they should not be a reason for serious concern. Copyright 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Joint Force Quarterly. Issue 45, 2d Quarter 2007

DTIC Science & Technology

2007-01-01

liberal institutional explana- tion for alliances, Ota is really describing how the Japan Self - Defense Forces (JSDF) worked to share the risk and try...training, intelligence, and civil affairs) the armed forces of the Philippines in their operations against Abu Sayyaf, a self -declared militant...was preoccupied with domestic difficulties and disasters (largely self -inflicted) and the daunting demands of economic development. But with the

The AMTEX Partnership{sup trademark}. Second quarter report. Fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemon, D.K.; Quisenberry, R.K.

1996-03-01

This quarterly report details activities of the AMTEX Partnership {sup TM} which is a collaborative research and development program among the U.S. Integrated Textile Industry, the Department of Energy (DOE), the national laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating U.S. jobs.

Surgery Branch recruiting patients to study new treatment for cancers with RAS mutations | Center for Cancer Research

Cancer.gov

RAS is a family of proteins that send signals to genes involved in cell growth and is mutated in approximately a quarter of all human cancers. James Yang, M.D., of the Surgery Branch is leading a team of investigators who have generated a special T-cell receptor from mouse cells that can recognize a mutation of RAS that is found in many human cancer cells. The goal is to determine if a new therapy is safe and can help shrink tumors that have the G12V RAS mutation. Read more...

Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases.

PubMed

Finlay, Conor M; Walsh, Kevin P; Mills, Kingston H G

2014-05-01

Helminth parasites are highly successful pathogens, chronically infecting a quarter of the world's population, causing significant morbidity but rarely causing death. Protective immunity and expulsion of helminths is mediated by T-helper 2 (Th2) cells, type 2 (M2) macrophages, type 2 innate lymphoid cells, and eosinophils. Failure to mount these type 2 immune responses can result in immunopathology mediated by Th1 or Th17 cells. Helminths have evolved a wide variety of approaches for immune suppression, especially the generation of regulatory T cells and anti-inflammatory cytokines interleukin-10 and transforming growth factor-β. This is a very effective strategy for subverting protective immune responses to prolong their survival in the host but has the bystander effect of modulating immune responses to unrelated antigens. Epidemiological studies in humans have shown that infection with helminth parasites is associated with a low incidence of allergy/asthma and autoimmunity in developing countries. Experimental studies in mice have demonstrated that regulatory immune responses induced by helminth can suppress Th2 and Th1/Th17 responses that mediate allergy and autoimmunity, respectively. This has provided a rational explanation of the 'hygiene hypothesis' and has also led to the exploitation of helminths or their immunomodulatory products in the development of new immunosuppressive therapies for inflammatory diseases in humans. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Dip-coating process: Silicon sheet growth development for the large-area silicon sheet task of the low-cost silicon solar array project

NASA Technical Reports Server (NTRS)

Zook, J. D.; Heaps, J. D.; Maciolek, R. B.; Koepke, B. G.; Gutter, C. D.; Schuldt, S. B.

1977-01-01

The objective of this research program is to investigate the technical and economic feasibility of producing solar-cell-quality sheet silicon by coating one surface of carbonized ceramic substrates with a thin layer of large-grain polycrystalline silicon from the melt. The past quarter demonstrated significant progress in several areas. Seeded growth of silicon-on-ceramic (SOC) with an EFG ribbon seed was demonstrated. Different types of mullite were successfully coated with silicon. A new method of deriving minority carrier diffusion length, L sub n from spectral response measurements was evaluated. ECOMOD cost projections were found to be in good agreement with the interim SAMIS method proposed by JPL. On the less positive side, there was a decrease in cell performance which we believe to be due to an unidentified source of impurities.

Infrared thermography of the udder surface of dairy cattle: characteristics, methods, and correlation with rectal temperature.

PubMed

Metzner, Moritz; Sauter-Louis, Carola; Seemueller, Andrea; Petzl, Wolfram; Klee, Wolfgang

2014-01-01

Thermograms of the caudal udder surface were taken of five healthy cows before and after inoculation of Escherichia coli into the right hind quarter. Images in clinically normal udder quarters from cows without fever (CN) were compared with those post inoculation when cows had fever (⩾ 39.5°C) and showed elevation of somatic cell counts (⩾ 400,000 cells/mL) in the inoculated quarter (CM). Using graphic software tools, different geometric analysis tools (GATs: polygons, rectangles, lines) were set within the thermographic images. The following descriptive parameters (DPs) were employed: minimum value ('min'), maximum value ('max'), range ('max-min'), and arithmetic mean ('am'). Surface temperatures in group CN were between 34.1°C ('polygons'/'min') and 37.9°C ('polygons'/'max'), and in group CM between 34.5°C ('polygons'/'min') and 40.0°C ('polygons'/'max'). The greatest differences in the temperatures between CN and CM (2.06°C) were found in 'polygons' and 'rectangles' using 'max'. The smallest coefficient of variation in triplicate determinations was found in GAT 'polygons' with DP 'max' (Tmax) (0.15%), and the relationship to the rectal body temperature (Tr) could be described by Tr=5.68+0.874*Tmax. The results show that significant changes can be displayed best using the GAT 'polygons' and the DP 'max'. These methods should be considered for automated monitoring of udder health in dairy cows. Copyright © 2013 Elsevier Ltd. All rights reserved.

ENERCA clinical recommendations for disease management and prevention of complications of sickle cell disease in children.

PubMed

de Montalembert, Mariane; Ferster, Alina; Colombatti, Raffaella; Rees, David C; Gulbis, Beatrice

2011-01-01

Universal neonatal screening is performed in the United States, England, the Netherlands, and several cities in Belgium, with selective screening targeted on "high-risk" population in France (globally, one quarter of all the babies born in France are screened). Newborns diagnosed with a major sickle cell syndrome (SCD) should be referred to a designated pediatric sickle cell centre, and the parents are informed that their child has SCD; this may be in the sickle cell centre by an expert physician or in the community by an experienced nurse counsellor. The pediatric sickle cell centre should organize the care of the baby.

Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.

PubMed

Hauswirth, Regula; Haase, Bianca; Blatter, Marlis; Brooks, Samantha A; Burger, Dominik; Drögemüller, Cord; Gerber, Vincent; Henke, Diana; Janda, Jozef; Jude, Rony; Magdesian, K Gary; Matthews, Jacqueline M; Poncet, Pierre-André; Svansson, Vilhjálmur; Tozaki, Teruaki; Wilkinson-White, Lorna; Penedo, M Cecilia T; Rieder, Stefan; Leeb, Tosso

2012-01-01

During fetal development neural-crest-derived melanoblasts migrate across the entire body surface and differentiate into melanocytes, the pigment-producing cells. Alterations in this precisely regulated process can lead to white spotting patterns. White spotting patterns in horses are a complex trait with a large phenotypic variance ranging from minimal white markings up to completely white horses. The "splashed white" pattern is primarily characterized by an extremely large blaze, often accompanied by extended white markings at the distal limbs and blue eyes. Some, but not all, splashed white horses are deaf. We analyzed a Quarter Horse family segregating for the splashed white coat color. Genome-wide linkage analysis in 31 horses gave a positive LOD score of 1.6 in a region on chromosome 6 containing the PAX3 gene. However, the linkage data were not in agreement with a monogenic inheritance of a single fully penetrant mutation. We sequenced the PAX3 gene and identified a missense mutation in some, but not all, splashed white Quarter Horses. Genome-wide association analysis indicated a potential second signal near MITF. We therefore sequenced the MITF gene and found a 10 bp insertion in the melanocyte-specific promoter. The MITF promoter variant was present in some splashed white Quarter Horses from the studied family, but also in splashed white horses from other horse breeds. Finally, we identified two additional non-synonymous mutations in the MITF gene in unrelated horses with white spotting phenotypes. Thus, several independent mutations in MITF and PAX3 together with known variants in the EDNRB and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.

Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

PubMed Central

Blatter, Marlis; Brooks, Samantha A.; Burger, Dominik; Drögemüller, Cord; Gerber, Vincent; Henke, Diana; Janda, Jozef; Jude, Rony; Magdesian, K. Gary; Matthews, Jacqueline M.; Poncet, Pierre-André; Svansson, Vilhjálmur; Tozaki, Teruaki; Wilkinson-White, Lorna; Penedo, M. Cecilia T.; Rieder, Stefan; Leeb, Tosso

2012-01-01

During fetal development neural-crest-derived melanoblasts migrate across the entire body surface and differentiate into melanocytes, the pigment-producing cells. Alterations in this precisely regulated process can lead to white spotting patterns. White spotting patterns in horses are a complex trait with a large phenotypic variance ranging from minimal white markings up to completely white horses. The “splashed white” pattern is primarily characterized by an extremely large blaze, often accompanied by extended white markings at the distal limbs and blue eyes. Some, but not all, splashed white horses are deaf. We analyzed a Quarter Horse family segregating for the splashed white coat color. Genome-wide linkage analysis in 31 horses gave a positive LOD score of 1.6 in a region on chromosome 6 containing the PAX3 gene. However, the linkage data were not in agreement with a monogenic inheritance of a single fully penetrant mutation. We sequenced the PAX3 gene and identified a missense mutation in some, but not all, splashed white Quarter Horses. Genome-wide association analysis indicated a potential second signal near MITF. We therefore sequenced the MITF gene and found a 10 bp insertion in the melanocyte-specific promoter. The MITF promoter variant was present in some splashed white Quarter Horses from the studied family, but also in splashed white horses from other horse breeds. Finally, we identified two additional non-synonymous mutations in the MITF gene in unrelated horses with white spotting phenotypes. Thus, several independent mutations in MITF and PAX3 together with known variants in the EDNRB and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes. PMID:22511888

A multilocation clinical trial in lactating dairy cows affected with clinical mastitis to compare the efficacy of treatment with intramammary infusions of a lincomycin/neomycin combination with an ampicillin/cloxacillin combination.

PubMed

Deluyker, H A; Chester, S T; Van Oye, S N

1999-08-01

A study was conducted to compare the efficacy in lactating dairy cows of intramammary infusions in quarters affected with clinical mastitis between a formulation containing 330 mg lincomycin and 100 mg neomycin in a 10-mL aqueous solution (LINCOCIN FORTE S, Pharmacia & Upjohn) and a formulation containing 75 mg ampicillin and 200 mg cloxacillin in an oil suspension (AMPICLOX, Pfizer Animal Health). This study was designed as a multicentre clinical trial involving investigators in France, Germany and Belgium and carried out according to the European Commission guidelines on Good Clinical Practices. Cows in the herds were monitored for clinical mastitis. When evidence of clinical mastitis was detected in a single quarter, a pretherapy milk sample was collected from the affected quarter. After milk sampling, the cow was assigned to one of the two treatment groups at random and treated with an intramammary infusion of one syringe of either LINCOCIN FORTE S or AMPICLOX for three successive milkings in the mastitic quarter. At 4-5, 13-15 and 20-22 days after first infusion, the veterinarian returned to the farm to conduct a clinical examination and collect milk samples from the affected quarter. Milk samples were cultured for the presence of mastitis organisms and somatic cell count (SCC) was measured. Following a 10-month study period, 256 cases were enrolled in the study. A total of 232 and 189 cases were analysed for clinical cure and for clinical-plus-bacteriological cure, respectively. The proportions of cases cured clinically and cured clinically-plus-bacteriologically were compared between the two treatment groups. Somatic cell count differences between treatment groups were also tested. The clinical cure rate for LINCOCIN FORTE S (62.5%) was significantly better than for AMPICLOX (51.8%) (P = 0.035). The clinical-plus-bacteriological cure rate was also significantly better for LINCOCIN FORTE S (38.1%) than for AMPICLOX (21.7%) (P = 0.005). Among bacteriologically cured cases, the SCC declined in both treatment groups but the SCC was significantly higher for the AMPICLOX group than for the LINCOCIN FORTE S group (P = 0.036). In conclusion, clinical cure rate, clinical-plus-bacteriological cure rate, and SCC level were significantly better with LINCOCIN FORTE S than for AMPICLOX.

Microscopic optical path length difference and polarization measurement system for cell analysis

NASA Astrophysics Data System (ADS)

Satake, H.; Ikeda, K.; Kowa, H.; Hoshiba, T.; Watanabe, E.

2018-03-01

In recent years, noninvasive, nonstaining, and nondestructive quantitative cell measurement techniques have become increasingly important in the medical field. These cell measurement techniques enable the quantitative analysis of living cells, and are therefore applied to various cell identification processes, such as those determining the passage number limit during cell culturing in regenerative medicine. To enable cell measurement, we developed a quantitative microscopic phase imaging system based on a Mach-Zehnder interferometer that measures the optical path length difference distribution without phase unwrapping using optical phase locking. The applicability of our phase imaging system was demonstrated by successful identification of breast cancer cells amongst normal cells. However, the cell identification method using this phase imaging system exhibited a false identification rate of approximately 7%. In this study, we implemented a polarimetric imaging system by introducing a polarimetric module to one arm of the Mach-Zehnder interferometer of our conventional phase imaging system. This module was comprised of a quarter wave plate and a rotational polarizer on the illumination side of the sample, and a linear polarizer on the optical detector side. In addition, we developed correction methods for the measurement errors of the optical path length and birefringence phase differences that arose through the influence of elements other than cells, such as the Petri dish. As the Petri dish holding the fluid specimens was transparent, it did not affect the amplitude information; however, the optical path length and birefringence phase differences were affected. Therefore, we proposed correction of the optical path length and birefringence phase for the influence of elements other than cells, as a prerequisite for obtaining highly precise phase and polarimetric images.

Risk factors for subclinical and clinical ketosis and association with production parameters in dairy cows in the Netherlands.

PubMed

Vanholder, T; Papen, J; Bemers, R; Vertenten, G; Berge, A C B

2015-02-01

Ketosis is associated with many transition cow diseases and the subclinical form has been found to be a common condition in high-producing dairy cows. The objectives of this field study in the Netherlands were (1) to determine risk factors for subclinical ketosis [SCK; 1.2-2.9mmol of β-hydroxybutyrate (BHBA)/L of serum] and clinical ketosis (CK: ≥3.0mmol of BHBA/L of serum) at 7 to 14 d in milk and (2) to assess the association of SCK and CK with production parameters at the first dairy herd improvement (DHI) testing. Twenty-three dairies were enrolled by a local veterinary practice from 2009 to 2010, and 1,715 cows were screened for ketosis by measuring serum BHBA concentrations at 7 to 14 d in milk. Overall, 47.2% of cows had SCK and 11.6% had CK. Mixed generalized logit models with a random effect of herd were used to evaluate cow level factors associated with SCK and CK. The associations of SCK and CK with milk production parameters were tested using mixed linear models with a random effect of herd. Cows at a moderate (3.25-3.75) or fat (≥4) body condition score before calving were more likely to develop SCK and CK than thin (body condition score≤3.0) cows. The risk for developing SCK was higher in parity 2 and older cows compared with heifers, whereas for CK only, parity ≥3 cows had a higher risk. The quarter of the year in which a cow calved was associated with the risk for SCK and CK. For SCK quarter 1 (January-March) and quarter 2 (April-June), and for CK quarter 1, quarter 2, and quarter 3 (July-September) all increased the risk of development of the condition compared with quarter 4 (October-December). An increased yield of colostrum at first milking was associated with increasing risk for SCK and CK. Prolonged previous lactation length and dry period length were both associated with increased odds for SCK and CK. Subclinical ketosis and CK were associated with a higher milk yield, a higher milk fat percentage, and a lower milk protein percentage at first DHI test day. Overall the study reinforces previous findings that the major risk factors for both SCK and CK are increasing parity, overconditioning of animals prepartum, season of calving, and dry period length. In addition, previous lactation length and liters of colostrum have been identified as additional risk factors for the development of ketosis. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Multi-dimensional PIC-simulations of parametric instabilities for shock-ignition conditions

NASA Astrophysics Data System (ADS)

Riconda, C.; Weber, S.; Klimo, O.; Héron, A.; Tikhonchuk, V. T.

2013-11-01

Laser-plasma interaction is investigated for conditions relevant for the shock-ignition (SI) scheme of inertial confinement fusion using two-dimensional particle-in-cell (PIC) simulations of an intense laser beam propagating in a hot, large-scale, non-uniform plasma. The temporal evolution and interdependence of Raman- (SRS), and Brillouin- (SBS), side/backscattering as well as Two-Plasmon-Decay (TPD) are studied. TPD is developing in concomitance with SRS creating a broad spectrum of plasma waves near the quarter-critical density. They are rapidly saturated due to plasma cavitation within a few picoseconds. The hot electron spectrum created by SRS and TPD is relatively soft, limited to energies below one hundred keV.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY13 Fourth Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

2013-12-02

This quarterly report summarizes the status of the project planning to obtain all the approvals required for a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). The final CRADA documents processed by PNNL’s Legal Services were submitted to all the parties for signatures.

Joint Force Quarterly. Issue 77, 2nd Quarter 2015

DTIC Science & Technology

2015-04-01

security required for storing or transfer- ring the data and whether the individual should be informed about potential uses of the data. It is also...decision relevance.7 The often repeated mantra in the social sciences, “correlation does not imply causation,” certainly rings true here. The popular...development of turbine jet engines by innovative scientists and engineers working with military personnel. The process involved nearly continuous insertion

Joint Force Quarterly. Issue 44, 1st Quarter 2007

DTIC Science & Technology

2007-01-01

the month before the earthquake , the U.S. military once again found itself cen- trally engaged in a familiar if rather new role conducting hurricane...effective in the 15th century were originally developed to make church bells . Dissemination and Nullification Moreover, few if any technologies, much...Liberto (available only at www.ndupress.ndu.edu) 14 Geospatial Intelligence: The New Discipline by Richard E. Barrowman (available only at

Reflections on the Last 25 Years of the American Otological Society and Thoughts on its Future.

PubMed

Welling, D Bradley; Jackler, Robert K

2018-04-01

To review contributions of the American Otological Society (AOS) over the most recent quarter century (1993-2018) and to comment on possible future evolution of the field during the quarter century to come. Retrospective review of selected topics from the AOS transactions, distinguished lectureships over the past 25 years, and selective reflection by the authors. Speculation on potential advances of the next quarter century derived from emerging topics in the current literature and foreseeable trends in science and technology are also proffered for consideration (and possible future ridicule). Integration of multiple disciplines including bioengineering, medical imaging, genetics, molecular biology, physics, and evidence based medicine have substantially benefitted the practice of otology over the past quarter century. The impact of the contributions of members of the AOS in these developments cannot be over estimated. Further scientific advancement will certainly accelerate change in the practice of otologic surgery and medicine over the coming decade in ways that will be marvelous to behold.

Three-quarter view preference for three-dimensional objects in 8-month-old infants.

PubMed

Yamashita, Wakayo; Niimi, Ryosuke; Kanazawa, So; Yamaguchi, Masami K; Yokosawa, Kazuhiko

2014-04-04

This study examined infants' visual perception of three-dimensional common objects. It has been reported that human adults perceive object images in a view-dependent manner: three-quarter views are often preferred to other views, and the sensitivity to object orientation is lower for three-quarter views than for other views. We tested whether such characteristics were observed in 6- to 8-month-old infants by measuring their preferential looking behavior. In Experiment 1 we examined 190- to 240-day-olds' sensitivity to orientation change and in Experiment 2 we examined these infants' preferential looking for the three-quarter view. The 240-day-old infants showed a pattern of results similar to adults for some objects, while the 190-day-old infants did not. The 240-day-old infants' perception of object view is (partly) similar to that of adults. These results suggest that human visual perception of three-dimensional objects develops at 6 to 8 months of age.

Automated technology to speed recognition of signs of illness in older adults.

PubMed

Rantz, Marilyn J; Skubic, Marjorie; Koopman, Richelle J; Alexander, Gregory L; Phillips, Lorraine; Musterman, Katy; Back, Jessica; Aud, Myra A; Galambos, Colleen; Guevara, Rainer Dane; Miller, Steven J

2012-04-01

Our team has developed a technological innovation that detects changes in health status that indicate impending acute illness or exacerbation of chronic illness before usual assessment methods or self-reports of illness. We successfully used this information in a 1-year prospective study to alert health care providers so they could readily assess the situation and initiate early treatment to improve functional independence. Intervention participants showed significant improvements (as compared with the control group) for the Short Physical Performance Battery gait speed score at Quarter 3 (p = 0.03), hand grip-left at Quarter 2 (p = 0.02), hand grip-right at Quarter 4 (p = 0.05), and the GAITRite functional ambulation profile score at Quarter 2 (p = 0.05). Technological methods such as these could be widely adopted in older adult housing, long-term care settings, and in private homes where older adults wish to remain independent for as long as possible. Copyright 2012, SLACK Incorporated.

Genetic and Environmental Pathways in Type 1 Diabetes Complication

DTIC Science & Technology

2008-06-01

obese diabetic mice. Biochem Biophys Res Commun 2002. 294:592-596. 4. Beyan H, Goodier MR, Nawroly NS, Hawa MI, Bustin SA, Ogunkolade WB, Londei M...peroxidation in patients with hyperglycemic crisis . Diabetes 2004. 53:2079-2086. 14 In our second quarterly scientific progress report (09/01/07 – 11...cells induced to differentiate into insulin-positive cells. Biochem Biophys Res Commun . 2007;357(2):414-20. 44. Takahashi K, Tanabe K, Ohnuki M, Narita

Urokinase receptor expression involves tyrosine phosphorylation of phosphoglycerate kinase.

PubMed

Shetty, Praveenkumar; Velusamy, Thirunavukkarasu; Bhandary, Yashodhar P; Liu, Ming C; Shetty, Sreerama

2010-02-01

The interaction of urokinase-type plasminogen activator (uPA) with its receptor, uPAR, plays a central role in several pathophysiological processes, including cancer. uPA induces its own cell surface receptor expression through stabilization of uPAR mRNA. The mechanism involves binding of a 51 nt uPAR mRNA coding sequence with phosphoglycerate kinase (PGK) to down regulate cell surface uPAR expression. Tyrosine phosphorylation of PGK mediated by uPA treatment enhances uPAR mRNA stabilization. In contrast, inhibition of tyrosine phosphorylation augments PGK binding to uPAR mRNA and attenuates uPA-induced uPAR expression. Mapping the specific peptide region of PGK indicated that its first quarter (amino acids 1-100) interacts with uPAR mRNA. To determine if uPAR expression by uPA is regulated through activation of tyrosine residues of PGK, we mutated the specific tyrosine residue and tested mutant PGK for its ability to interfere with uPAR expression. Inhibition of tyrosine phosphorylation by mutating Y76 residue abolished uPAR expression induced by uPA treatment. These findings collectively demonstrate that Y76 residue present in the first quarter of the PGK molecule is involved in lung epithelial cell surface uPAR expression. This region can effectively mimic the function of a whole PGK molecule in inhibiting tumor cell growth.

A Multistage R & D Project Selection Model with Multiple Objectives.

DTIC Science & Technology

1979-01-01

Hart, "A Chart for Evaluating Product Research and Develop- ment Projects," Operations Research Quarterly, Vol. 17 (December, 1966), pp. 347 -358. R...ff -a t -V v -t #i CNICICSI NN 񔰅 N OCOC2 00 14:5 C U,’ 168 ~O N w- ED ucO 04" 04 c . 1f.4; v LI . H 4 m.-) HML 0 0 m n bw3 NOWO 0- . -Jr.J 44 V...34 Operations Research Quarterly, Vol. 17 (December, 1966), pp. 347 -358. _ "Evaluation of Research and Development Projects," Chemistry and Industry (March

Enzymatic desulfurization of coal: Third quarterly report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marquis, Judith K.; Kitchell, Judith P.

Our current efforts to develop clean coal technology emphasize the advantages of enzymatic desulfurization techniques and have specifically addressed the potential of using partially-purified extracellular microbial enzymes or commercially available enzymes. Our work is focused on the treatment of ''model'' organic sulfur compounds such as dibenzothiophene (DBT) and ethylphenylsulfide (EPS). Furthermore, we are designing experiments to facilitate the enzymatic process by means of a hydrated organic solvent matrix. In this quarter we obtained important results both with the development of our understanding of the enzyme reaction systems and also with the microbial work at Woods Hole. 12 figs., 11 tabs.

Single frequency stable VCSEL as a compact source for interferometry and vibrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudzik, Grzegorz; Rzepka, Janusz

2010-05-28

Developing an innovative PS-DAVLL (Polarization Switching DAVLL) method of frequency stabilization, which used a ferroelectric liquid crystal cell as quarter wave plate, rubidium cell and developed ultra-stable current source, allowed to obtain a frequency stability of 10{sup -9}(frequency reproducibility of 1,2centre dot10{sup -8}) and reductions in external dimensions of laser source. The total power consumption is only 1,5 Watt. Because stabilization method used in the frequency standard is insensitive to vibration, the semiconductor laser interferometer was built for measuring range over one meter, which can also be used in industry for the accurate measurement of displacements with an accuracy ofmore » 1[mum/m]. Measurements of the VCSEL laser parameters are important from the standpoint of its use in laser interferometry or vibrometry, like narrow emission line DELTAnu{sub FWHM} = 70[MHz] equivalent of this laser type and stability of linear polarization of VCSEL laser. The undoubted advantage of the constructed laser source is the lack of mode-hopping effect during continuous work of VCSEL.« less

Advanced Thermal Emission Imaging Systems Definition and Development

NASA Technical Reports Server (NTRS)

Blasius, Karl; Nava, David (Technical Monitor)

2002-01-01

Santa Barbara Remote Sensing (SBRS), Raytheon Company, is pleased to submit this quarterly progress report of the work performed in the third quarter of Year 2 of the Advanced THEMIS Project, July through September 2002. We review here progress in the proposed tasks. During July through September 2002 progress was made in two major tasks, Spectral Response Characterization and Flight Instrument Definition. Because of staffing problems and technical problems earlier in the program we have refocused the remaining time and budget on the key technical tasks. Current technical problems with a central piece of test equipment has lead us to request a 1 quarter extension to the period of performance. This request is being made through a separate letter independent of this report.

Stem cell tourism--a web-based analysis of clinical services available to international travellers.

PubMed

Connolly, Ruairi; O'Brien, Timothy; Flaherty, Gerard

2014-01-01

Stem cell therapies are advertised through online resources which describe a range of treatments with diverse clinical indications. Stem cell tourists may not be aware of the information they should seek when consulting these clinics, or of the potential risks involved. The aim of this study was to characterise the therapies offered by online stem cell clinics. A web based search utilising five search terms was employed. The first twenty pages of each search result were screened against 340 variables. 224 out of 1091 websites advertised stem cell clinics. 68 eligible sites covering 21 countries were evaluated. The top five clinical indications for stem cell therapy were multiple sclerosis, anti-ageing, Parkinson's disease, stroke and spinal cord injury. Adult, autologous stem cells were the most commonly utilised stem cell, and these were frequently sourced from bone marrow and adipose tissue and administered intravenously. Thirty-four per cent of sites mentioned the number of patients treated while one quarter of clinics provided outcome data. Twenty-nine per cent of clinics had an internationally recognised accreditation. Fifteen per cent of clinics stated that their therapies posed no risk. Eighty-eight per cent of clinics claimed treatment effectiveness, with 16% describing their curative potential. Over 40% of sites did not specify the number or duration of treatments. Fifty-three per cent of clinics requested access to patients' medical records, and 12% recommended patients discuss the proposed therapy with their doctor. No clinic recommended that travellers consult a travel medicine specialist or receive vaccinations prior to their intended travel. One quarter of sites discussed contraindications to treatment, with 41% of sites detailing follow up patient care. There is potential for stem cell tourists to receive misleading or deficient information from online stem cell clinics. Both the stem cell tourist and travel medicine practitioner should be educated on the potential risks associated with stem cell clinical services advertised online.

4. Northeast corner of quarters (executive officer's quarters), looking onto ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northeast corner of quarters (executive officer's quarters), looking onto Quarter R (commanding officer's quarters), looking southeast - Naval Air Station Chase Field, Texas State Highway 202, 4.8 miles east of intersection of Texas State Highway 202 & U.S. State Highway 181, Beeville, Bee County, TX

Catalysts and process development for two-stage liquefaction. First quarterly report, January 1, 1992--March 31, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cronauer, D.C.; Swanson, A.J.; Sajkowski, D.J.

Research under way in this project centers upon developing and evaluating catalysts and process improvements for coal liquefaction in the two-stage, close-coupled catalytic process. The project is being carried out under contract to the United States Department of Energy. As discussed in the previous quarterly report, promising results were obtained by liquefying Illinois No. 6 bituminous and Black Thunder subbituminous coals using oil-soluble catalysts Molyvan L and molybdenum octoate. In this quarter, the liquefaction of Black Thunder coal was continued. Runs were made in catalytic/thermal (C/T) mode with supported AMOCAT{trademark} 1C (NiMo) and AMOCAT{trademark} 1B (Mo) catalysts. Although the initialmore » performance in these runs was good (90% conversion with no resid production), both catalysts deactivated rapidly. Spent catalysts showed severe coke deposition as well as formation of a calcium-rich shell on the catalyst surface. Overall, C/T liquefaction is not a good process option for Black Thunder coal.« less

Joint Force Quarterly. Issue 65, 2nd Quarter 2012

DTIC Science & Technology

2012-04-01

but other times misfortune arrives unan- nounced. Strong organizations build on the mutual support of every member of the unit. This is the essence of...devote themselves to putting themselves into others’ heads. They concen- trate on boring down to a character’s essence , stripping away pretext to...style ‘ jasmine revolution’ circulated on the internet.”17 A postscript on developments in Libya makes clear that economic deprivation is at the

Joint Force Quarterly. Issue 72, 1st Quarter 2014

DTIC Science & Technology

2014-01-01

assumptions. Planners may assume a sensor is adequate for finding IEDs but must develop a feedback loop that focuses on the interplay of enemy and friendly...AD challenge: how to maintain sensor and weapons density at distance, over time, without forward bases or aircraft carriers. Overcoming this...capabilities such as cyber warfare.3 It also requires unconventional thinking about how the U.S. military Services combine sensors , weapons, and platforms to

Joint Force Quarterly. Issue 57, 2nd Quarter 2010

DTIC Science & Technology

2010-04-01

nevertheless poured in from home and abroad. Subsequent Sidetracks At age 51, I shed the uniform of an Army colonel on Friday, May 31, 1972, and the...necessitating the state of emergency Azerbaijani and turkish officials in Ankara discuss agreement establishing diplomatic relations A P Im ag es (U m it...the Army’s Rapid Equipping Force to develop a portable renewable /hybrid energy supply system, demonstrated at the National Training Center but not

Joint Force Quarterly. Issue 48, 1st Quarter 2008

DTIC Science & Technology

2008-01-01

Closure and joint basing initiatives. n Engage in the development of a broad- based, flexible, effective , and affordable joint military health care system...in a London hospital in November 2006 due to ingested alpha particles from Polonium 210 . Just the trace trail of Polonium 210 across the city and...can we adequately defend the Nation. Therefore, we will: n Determine the true health of our ground forces in terms of people, training, equipment

Lawrence Livermore National Laboratory Safeguards and Security quarterly progress report to the US Department of Energy: Quarter ending December 31, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

1994-01-01

The Lawrence Livermore National Laboratory (LLNL) carries out safeguards and security activities for the Department of Energy (DOE), Office of Safeguards and Security (OSS), as well as other organizations, both within and outside the DOE. This document summarizes the activities conducted for the OSS during the first quarter of fiscal year 1994 (October through December, 1993). The nature and scope of the activities carried out for OSS at LLNL require a broad base of technical expertise. To assure projects are staffed and executed effectively, projects are conducted by the organization at LLNL best able to supply the needed technical expertise.more » These projects are developed and managed by senior program managers. Institutional oversight and coordination is provided through the LLNL Deputy Director`s office. At present, the Laboratory is supporting OSS in five areas: (1) Safeguards Technology, (2) Safeguards and Decision Support, (3) Computer Security, (4) DOE Automated Physical Security, and (5) DOE Automated Visitor Access Control System. This report describes the activities in each of these five areas. The information provided includes an introduction which briefly describes the activity, summary of major accomplishments, task descriptions with quarterly progress, summaries of milestones and deliverables and publications published this quarter.« less

Lawrence Livermore National Laboratory safeguards and security quarterly progress report to the U.S. Department of Energy. Quarter ending December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

The Lawrence Livermore National Laboratory (LLNL) carries out safeguards and security activities for the Department of Energy (DOE), Office of Safeguards and Security (OSS), as well as other organizations, both within and outside the DOE. This document summarizes the activities conducted for the OSS during the First Quarter of Fiscal Year 1997 (October through December, 1996). The nature and scope of the activities carried out for OSS at LLNL require a broad base of technical expertise. To assure projects are staffed and executed effectively, projects are conducted by the organization at LLNL best able to supply the needed technical expertise.more » These projects are developed and managed by senior program managers. Institutional oversight and coordination is provided through the LLNL Deputy Director`s office. At present, the Laboratory is supporting OSS in four areas: (1) safeguards technology; (2) safeguards and material accountability; (3) computer security--distributed systems; and (4) physical and personnel security support. The remainder of this report describes the activities in each of these four areas. The information provided includes an introduction which briefly describes the activity, summary of major accomplishments, task descriptions with quarterly progress, summaries of milestones and deliverables and publications published this quarter.« less

Designing Birefringent Filters For Solid-State Lasers

NASA Technical Reports Server (NTRS)

Monosmith, Bryan

1992-01-01

Mathematical model enables design of filter assembly of birefringent plates as integral part of resonator cavity of tunable solid-state laser. Proper design treats polarization eigenstate of entire resonator as function of wavelength. Program includes software modules for variety of optical elements including Pockels cell, laser rod, quarter- and half-wave plates, Faraday rotator, and polarizers.

New method of metallization for silicon solar cells. Second quarterly report, April 1-June 30, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macha, M.

1979-01-01

The second quarter of this program is concerned with the determination of the firing cycle in a horizontal tube furnace for MoO/sub 3/:Sn ink composition applied by silk screening process on P on N structured solar cells. In comparison with the strip heater used in the first quarter to determine the reaction mechanism, the reduction of MoO/sub 3/ in the tube furnace progresses at a much faster rate and the Sn:Mo alloy forms at a much lower temperature. The device characteristics determined by the V-I curve showed a high resistance (approx. 10 Ohms) at peak temperatures between 600/sup 0/C andmore » 800/sup 0/C. The high series resistance can be attributed to the lack of formation of MoSi/sub 2/ within the used temperature range as pointed out in references to theoretical and experimental work concerned with the formation of metal silicides. According to these references this temperature range is right for the formation of silicide of titanium, which, besides having a lower resistance value, forms in the presence of an oxidized silicon surface. Therefore the basic MoO/sub 3/ ink composition was modified by an addition of titanium resinate corresponding to a titanium concentration of 1-15000 based on the solids in the mixture. The addition of titanium decreased the series resistance to the level of 1 Ohm or better and the device characteristics were comparable with the devices metallized by electroless nickel and silk screened silver.« less

Flotation of mastitis pathogens with cream from subclinically infected quarters. Prospects for developing a cream-rising test for detecting mastitis caused by major mastitis pathogens.

PubMed

Sandholm, M; Kaartinen, L; Hyvönen, P; Veijalainen, K; Kuosa, P L

1989-02-01

Bacterial isolates, originating from 36 subclinically infected quarter milk samples, were labelled with 75Se and checked for cream-rising at various temperatures in a system analogous to the ABR test ("Abortus Bang Ringprobe"; the cream-rising test based on stained brucella organisms for detection of brucellosis). Diagnostic specificity and sensitivity were analyzed in experiments where labelled bacterial isolates were mixed with a number of quarter milk samples with known bacteriological status as well as samples from healthy control quarters. Creaming at 37 degrees C resulted in specific "recognization" as the bacterial isolates showed preferential flotation in the milk samples from which they had been isolated as well as is milk samples harbouring the same bacterial species. At lower creaming temperatures, the specificity was lost since all the isolates became concentrated in the cream phase irrespective of the milk sample. When comparing the specific recognization by cream of the respective bacteria, bacterial species vary: The prospects for developing diagnostic cream-rising tests for Streptococcus agalactiae, Staphylococcus aureus and Escherichia coli seems promising, but less so for coagulase-negative staphylococci, Streptococcus dysgalactiae, and Streptococcus uberis. The mechanism behind the cream-rising of labelled bacteria at 37 degrees C seems to lie in specific fat globule membrane-bound immunity of IgA type. Therefore the milk fat globules from chronically infected quarters function as absorbents for the respective isolates. Flotation of bacteria with cream indicates an in vivo mechanism enabling bacteria to invade the upper parts of milk ducts within the udder.(ABSTRACT TRUNCATED AT 250 WORDS)

[Empowerment by capacity building in urban quarters--first results and assessment of a new standardised instrument].

PubMed

Trojan, A; Nickel, S

2008-12-01

Capacity building is regarded as an intermediate outcome and success parameter for community health promotion and empowerment. The first aim of the study was the development and examination of a tool to measure capacity building in the context of a programme of health promotion for children and parents in a socially disadvantaged quarter in Hamburg (about 3000 residents, 60% with migration background). The second aim was to measure capacity building within a period of five years. A survey was carried out with 27 professionals from the health and social field. Dimensions of the instrument were: citizen participation, local leadership, available resources, networking and co-operation, support of residents. At the same time, we tested to what extent the instrument is suitable for resident surveys. Furthermore, pretest instrument and results were discussed with our advisory board regarding potential improvements. The result of the project, in addition to its practical use in the quarter, consists of the generation of a psychometrically tested instrument to measure capacity building. Furthermore, the experience contributed to the expertise on how such a study can be conducted. A comparison of the situation in 2006 with the situation in 2001 showed considerable improvements in all dimensions of capacity building in the quarter. Establishing the instrument on a long-term basis calls for more intensive examination not only of the chances, but also the limitations of the tool. We mainly attribute the overall positive picture that was gained within a period of five years to the generally supportive climate of development in the quarter as well as to the strong and continuous commitment of individual persons involved.

Wave Reflection and Loss Characteristics of an Emerged Quarter Circle Breakwater with Varying Seaside Perforations

NASA Astrophysics Data System (ADS)

Binumol, S.; Rao, Subba; Hegde, Arkal Vittal

2017-09-01

Breakwaters are one of the most important harbour structures constructed to withstand and dissipate the dynamic energy due to the action of the waves. Due to fast growing need of the universe and advances in technology different types of breakwaters are being developed. Quarter circle breakwater is a new type of breakwater emerged from semi circular breakwater and the first model was developed in Peoples Republic of China (2006). Quarter circle breakwater with perforations posses merits of caisson as well as perforated breakwaters such as low weight, requires less materials, suited for poor soil conditions, easily transported, handled and placed at the site, aesthetically pleasing, cost effective, eco-friendly and stable. Therefore it is necessary to carry out detailed studies on hydrodynamic characteristics to investigate the suitability and applicability of various types of quarter circle breakwaters. The present study investigates the wave reflection and loss characteristics of an emerged seaside perforated quarter circle breakwater of radius 55 cm and with varying ratios of spacing to diameter of perforations, for different water depths and wave conditions. The tests were conducted in the two-dimensional monochromatic wave flume available in Marine Structures laboratory of Department of Applied Mechanics and Hydraulics of National Institute of Technology, Surathkal, Karnataka, India. The results were plotted as non-dimensional graphs and it was observed that the reflection coefficient increases with increase in wave steepness for all values of ratio of height of breakwater structure to water depth. For a constant water depth, wave reflection increases with increase in ratio of spacing to diameter of perforations. It was also found that the loss coefficient decreases with increase in wave steepness for all values of ratio of height of breakwater structure to water depth, and ratio of spacing to diameter of perforations.

Do embryonic polar bodies commit suicide?

PubMed

Fabian, Dušan; Čikoš, Štefan; Rehák, Pavol; Koppel, Juraj

2014-02-01

The extrusion and elimination of unnecessary gametic/embryonic material is one of the key events that determines the success of further development in all living organisms. Oocytes produce the first polar body to fulfill the maturation process just before ovulation, and release the second polar body immediately after fertilization. The aim of this study was to compile a physiological overview of elimination of polar bodies during early preimplantation development in mice. Our results show that three-quarters of the first polar bodies were lost even at the zygotic stage; the 4-cell stage embryos contained only one (second) polar body, and the elimination of second polar bodies proceeded continuously during later development. Both first and second polar bodies showed several typical features of apoptosis: phosphatidylserine redistribution (observed for the first time in the first polar body), specific DNA degradation, condensed nuclear morphology, and inability to exclude cationic dye from the nucleus during the terminal stage of the apoptotic process. Caspase-3 activity was recorded only in the second polar body. From the morphological point of view, mouse polar bodies acted very similarly to damaged embryonic cells which have lost contact with their neighboring blastomeres. In conclusion, polar bodies possess all the molecular equipment necessary for triggering and executing an active suicide process. Furthermore, similarly as in dying embryonic cells, stressing external conditions (culture in vitro) might accelerate and increase the incidence of apoptotic elimination of the polar bodies in embryos.

3. Southwest side of quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters R (commanding officer's quarters), looking east - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Interior of quarters (executive officer's quarters), living room, looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior of quarters (executive officer's quarters), living room, looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. North side of quarters (executive officer's quarters), looking southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. North side of quarters (executive officer's quarters), looking southeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. East side of quarters (executive officer's quarters), looking west ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. East side of quarters (executive officer's quarters), looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Northeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Northeast side of Quarters R (commanding officer's quarters), looking west - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. West side of quarters (executive officer's quarters), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. West side of quarters (executive officer's quarters), looking east - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southeast side of Quarters R (commanding officer's quarters), looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. Northwest side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northwest side of Quarters R (commanding officer's quarters), looking southeast - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. South side of quarters (executive officer's quarters), looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. South side of quarters (executive officer's quarters), looking north - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Southwest side of quarters (executive officer's quarters), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters (executive officer's quarters), looking northeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Transportable and vibration-free full-field low-coherent quantitative phase microscope

NASA Astrophysics Data System (ADS)

Yamauchi, Toyohiko; Yamada, Hidenao; Goto, Kentaro; Matsui, Hisayuki; Yasuhiko, Osamu; Ueda, Yukio

2018-02-01

We developed a transportable Linnik-type full-field low-coherent quantitative phase microscope that is able to compensate for optical path length (OPL) disturbance due to environmental mechanical noises. Though two-beam interferometers such as Linnik ones suffer from unstable OPL difference, we overcame this problem with a mechanical feedback system based on digital signal-processing that controls the OPL difference in sub-nanometer resolution precisely with a feedback bandwidth of 4 kHz. The developed setup has a footprint of 200 mm by 200 mm, a height of 500 mm, and a weight of 4.5 kilograms. In the transmission imaging mode, cells were cultured on a reflection-enhanced glass-bottom dish, and we obtained interference images sequentially while performing stepwise quarter-wavelength phase-shifting. Real-time image processing, including retrieval of the unwrapped phase from interference images and its background correction, along with the acquisition of interference images, was performed on a laptop computer. Emulation of the phase contrast (PhC) images and the differential interference contrast (DIC) images was also performed in real time. Moreover, our setup was applied for full-field cell membrane imaging in the reflection mode, where the cells were cultured on an anti-reflection (AR)-coated glass-bottom dish. The phase and intensity of the light reflected by the membrane revealed the outer shape of the cells independent of the refractive index. In this paper, we show imaging results on cultured cells in both transmission and reflection modes.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY13 Third Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

2013-08-06

This quarterly report summarizes the status for the project planning to obtain all the approvals required for a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). The CRADA documents have been processed by PNNL Legal Services that is also coordinating the revision effort with the industrial parties to address DOE’s comments.

The application of MATLAB-based analytic hierarchy process in Hainan residential quarter function factor evaluation

NASA Astrophysics Data System (ADS)

Qiu, Dongdong; Liu, Peiqi

2017-04-01

Since being designated as an international tourist island, Hainan has become an overwhelmingly favored choice of real estate investment. This paper first constructed Hainan residential quarter function factor index system, then evaluated relevant factors, and finally solved the problem of factor importance ranking. In this specific case, the software MATLAB was used to facilitate AHP calculation. The evaluation results have guiding and referential value to both real estate developers and residential consumers.

Joint Force Quarterly. Issue 56, 1st Quarter, January 2010

DTIC Science & Technology

2010-01-01

He opines that “building a rudi- mentary state, even a flawed one that is able to provide a modicum of security and gover - nance to its people, is...as its ethos to balance tribal elites and powerbrokers that often remain wedded to benefiting their peers. Third, the concept of official gover ...American approach. A renewed U.S. commitment to funding grassroots development and gover - nance must accompany the influx of troops. The Afghan

Joint Force Quarterly. Issue 64, 1st Quarter 2012

DTIC Science & Technology

2012-01-01

Zad out, and the district gover - nor and army came in. Now kids there go to school. So now even Now Zad is one of the proof-of-concept areas. Does...compared to PRT operations since their aim is also to improve security, stability, and gover - nance through multiple agencies in coordina- tion with the...Mauritius focused on developing a manufac- turing hub and financial and tourism service centers, with a $750-million investment; and two in Nigeria

CONCEPTUAL DESIGN ASSESSMENT FOR THE CO-FIRING OF BIO-REFINERY SUPPLIED LIGNIN PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ted Berglund; Jeffrey T. Ranney; Carol L. Babb

2001-04-01

The major aspects of this project are proceeding toward completion. Prior to this quarter, design criteria, tentative site selection, facility layout, and preliminary facility cost estimates have been completed and issued for review. Processing of bio-solids was completed, providing material for the pilot operations. Pilot facility design, equipment selection, and modification were completed during the fourth quarter of 2000. Initial pilot facility shakedown was completed during the fourth quarter. After some unavoidable delays, a suitable representative supply of municipal solid waste (MSW) feed material was procured. During this quarter (first quarter of 2001), shredding of the feed material was completedmore » and final feed conditioning was completed. Pilot facility hydrolysis production was completed to produce lignin for co-fire testing. Pilot facility modifications continued to improve facility operations and performance during the first quarter of 2001. Samples of the co-fire fuel material were sent to the co-fire facility for evaluation. The TVA-Colbert facility has neared completion of the task to evaluate the co-location of the Masada facility on the operation of the power generation facility. The TVA-Colbert fossil plant is fully capable of providing a reliable steam supply. The preferred steam supply connection points and steam pipeline routing have been identified. The environmental review of the pipeline routing has been completed and no major impacts have been identified. Detailed assessment of steam export impacts on the Colbert boiler system have been completed and a cost estimate for steam supply system is being developed.« less

5. Interior of Quarters R (commanding officer's quarters), living room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Interior of Quarters R (commanding officer's quarters), living room, looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

An Econometric Model of Healthcare Demand With Nonlinear Pricing.

PubMed

Kunz, Johannes S; Winkelmann, Rainer

2017-06-01

From 2004 to 2012, the German social health insurance levied a co-payment for the first doctor visit in a calendar quarter. We develop a new model for estimating the effect of such a co-payment on the individual number of visits per quarter. The model combines a one-time increase in the otherwise constant hazard rate determining the timing of doctor visits with a difference-in-differences strategy to identify the reform effect. An extended version of the model accounts for a mismatch between reporting period and calendar quarter. Using data from the German Socio-Economic Panel, we do not find an effect of the co-payment on demand for doctor visits. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The magnetohydrodynamics coal-fired flow facility

NASA Astrophysics Data System (ADS)

1995-01-01

In this quarterly technical progress report, UTSI reports on the status of a multitask contract to develop the technology for the steam bottoming portion of a MHD Steam Combined Cycle Power Plant. The report describes the facility maintenance and environmental work completed, status of completing technical reports and certain key administrative actions occurring during the quarter. With program resources at a minimum to closeout the MHD program, no further testing occurred during the quarter, but the DOE CFFF facility was maintained in a standby status with winterization, preventive maintenance and repairs accomplished as needed. Plans and preparations progressed for environmental actions needed at the site to investigate and characterize the groundwater and for removal/disposal of asbestos in the cooling tower. Work continued to progress on archiving the results of the MHD program.

Summary Report on Solid-oxide Electrolysis Cell Testing and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.E. O'Brien; X. Zhang; R.C. O'Brien

2012-01-01

Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cells (SOECs) for large-scale hydrogen production from steam over a temperature range of 800 to 900 C. From 2003 to 2009, this work was sponsored by the United States Department of Energy Nuclear Hydrogen Initiative, under the Office of Nuclear Energy. Starting in 2010, the high-temperature electrolysis (HTE) research program has been sponsored by the INL Next Generation Nuclear Plant Project. This report provides a summaryof program activities performed in Fiscal Year (FY) 2011 and the first quarter of FY-12, with a focus on small-scale testing and cellmore » development activities. HTE research priorities during this period have included the development and testing of SOEC and stack designs that exhibit high-efficiency initial performance and low, long-term degradation rates. This report includes contributions from INL and five industry partners: Materials and Systems Research, Incorporated (MSRI); Versa Power Systems, Incorporated (VPS); Ceramatec, Incorporated; National Aeronautics and Space Administration - Glenn Research Center (NASA - GRC); and the St. Gobain Advanced Materials Division. These industry partners have developed SOEC cells and stacks for in-house testing in the electrolysis mode and independent testing at INL. Additional fundamental research and post-test physical examinations have been performed at two university partners: Massachusetts Institute of Technology (MIT) and the University of Connecticut. Summaries of these activities and test results are also presented in this report.« less

DEVELOPING A COST EFFECTIVE ENVIRONMENTAL SOLUTION FOR PRODUCED WATER AND CREATING A ''NEW'' WATER RESOURCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glenn Doran

1997-04-28

This report summarizes the status of this project for the quarter January 1, 1997 to March 31, 1997. Phase II has been started and Task 7, Develop Pilot Scale Test Work Plan has been completed. The operational portion of this phase, Task 8 has been initiated with several pieces of pilot equipment already on-site. The start up of the full process train will not occur until the next quarter. The project is slightly behind schedule. A no cost extension was requested and was granted. The anticipated completion date is December 31, 1997. The project is on budget.

33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

Code of Federal Regulations, 2012 CFR

2012-07-01

... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

Code of Federal Regulations, 2011 CFR

2011-07-01

... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

Code of Federal Regulations, 2013 CFR

2013-07-01

... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

Gasification in pulverized coal flames. First quarterly progress report, July--September 1975

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laurendeau, N. M.

1975-10-01

This project is concerned with the production of power and synthesis gases from pulverized coal via suspension gasification. Specifically, the concentric jet and vortex gasifiers, with separation of oxidation and reduction zones, will be investigated. Gasifier performance will be correlated with internally measured temperature and concentration profiles. A suction pyrometer will be used to simultaneously measure temperature and gas concentrations. Rapid species analysis will be provided by a UTI Q-30C mass spectrometer system. To date, a coal-handling facility has been developed, test cell design has been initiated, and preliminary literature searches have been made. A coal crusher, pulverizer, feeder, andmore » sieve shaker are on order. Preliminary consultations are underway concerning the mass spectrometer system. (auth)« less

10. Credit USAF, 7 September 1945. Original housed in the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Credit USAF, 7 September 1945. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 - 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. View looks northwest into jet engine test cell located on aircraft apron southeast of Building 4305. In background of photo can be seen doors of Unicon Portable Hangar on left, and southeast end of Building T-l Bachelor Officers' Quarters ("Desert Rat Hotel"). This view emphasizes the hangar's role as a test facility for developing and testing aircraft and aircraft systems, not simply as a "garage" for aircraft. - Edwards Air Force Base, North Base, Unicon Portable Hangar, First & C Streets, Boron, Kern County, CA

Therapeutic HPV vaccines.

PubMed

Hancock, Gemma; Hellner, Karin; Dorrell, Lucy

2018-02-01

High-risk human papillomavirus (HPV) infection is known to be a necessary factor for cervical and anogenital malignancies. Cervical cancers account for over a quarter of a million deaths annually. Despite the availability of prophylactic vaccines, HPV infections remain extremely common worldwide. Furthermore, these vaccines are ineffective at clearing pre-existing infections and associated preinvasive lesions. As cervical dysplasia can regress spontaneously, a therapeutic HPV vaccine that boosts host immunity could have a significant impact on the morbidity and mortality associated with HPV. Therapeutic vaccines differ from prophylactic vaccines in that they are aimed at generating cell-mediated immunity rather than neutralising antibodies. This review will cover various therapeutic vaccine strategies in development for the treatment of HPV-associated lesions and cancers. Copyright © 2017 Elsevier Ltd. All rights reserved.

Herd- and cow-level risk factors associated with subclinical mastitis in dairy farms from the High Plains of the northern Antioquia, Colombia.

PubMed

Ramírez, N F; Keefe, G; Dohoo, I; Sánchez, J; Arroyave, O; Cerón, J; Jaramillo, M; Palacio, L G

2014-07-01

Mastitis is the main disease entity affecting dairy farms in the Colombian High Plains of northern Antioquia, Colombia. However, no previous epidemiologic studies have determined the characteristics that increase the risk of infection in this region, where manual milking is still the prevailing system of milking. A 24-mo longitudinal study was designed to identify the predominant mastitis pathogens and important herd- and cow-level risk factors. Monthly visits were made to 37 commercial dairy farms to collect herd- and cow-level data and milk samples. Herd size varied from 6 to 136 cows (mean 37.0, median 29). Herd-level factors included type of milking system (manual or mechanical) and a range of management practices recommended by the National Mastitis Council (Madison, WI) to prevent mastitis. Individual cow-level risk factors included parity, stage of lactation, breed, udder hygiene, and lameness. A logistic regression analysis was used to investigate associations between herd- and cow-level risk factors with the presence of subclinical mastitis and infection caused by Streptococcus agalactiae at the quarter level. A quarter was considered to have subclinical mastitis if it had a positive California Mastitis Test and was subsequently confirmed to have a somatic cell count of ≥200,000 cells/mL. Any cow with one or more quarters with subclinical mastitis was considered to have subclinical mastitis at the cow level. Using 17,622 cow observations, the mean prevalence of subclinical mastitis at the cow level was 37.2% (95% confidence interval: 31.2, 43.3) for the first month and did not substantially change throughout the study. The predominant microorganisms isolated from quarters meeting the subclinical mastitis definition were contagious pathogens, including Strep. agalactiae (34.4%), Corynebacterium spp. (13.2%), and Staphylococcus aureus (8.0%). Significant variables associated with subclinical mastitis risk at the quarter level included being a purebred Holstein cow, higher parity, and increased months in milk. Variables that were protective for mastitis risk included being a crossbreed cow and adequate premilking udder hygiene. Significant variables associated with Strep. agalactiae infection were higher parity, increased months in milk, and manual milking. Variables that were protective were postmilking teat dipping and adequate cleaning of the udder. The results highlight the importance of hygiene practices in contagious mastitis control in manually milked herds. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Different screening tests and milk somatic cell count for the prevalence of subclinical bovine mastitis in Bangladesh.

PubMed

Hoque, Md Nazmul; Das, Ziban Chandra; Talukder, Anup Kumar; Alam, Mohammad Shah; Rahman, Abu Nasar Md Aminoor

2015-01-01

Identification of cows with subclinical mastitis (SCM) is an important tool for sustainable dairying and implementing effective mastitis control strategies. A total of 892 quarters milk samples from 228 lactating cows were screened by California mastitis test (CMT), White side test (WST), Surf field mastitis test (SFMT), and somatic cell count (SCC) to study the prevalence of bovine SCM in some selected areas of Bangladesh. Out of 228 cows, 148 (64.9%), 138 (60.5%), 132 (57.9%), and 164 (71.9%) were found positive for SCM by CMT, WST, SFMT, and SCC, respectively. The prevalence of bovine SCM was diagnosed 45.7, 40.2, 36.6, and 29.6% in Chittagong, Sirajgonj, Mymensingh, and Gazipur districts, respectively, based on a combination of all tests. The overall quarter-wise prevalence of SCM was 45.7, 43.5, 41.2, and 55.0% for CMT, WST, SFMT, and SCC. Single quarters and left front quarters were more prone to SCM (P < 0.05). Friesian crossbred cows (56.4%), BCS 2.0-2.5 (55.4%), and parity 4-6 (52.4%), the late lactation stage (5-8 months; 64.7%) and high yielding cows (16-20 L/day; 65.3%) were more susceptible to SCM (P < 0.05). The sensitivity of the CMT, WST, SFMT, and SCC was 65.8, 57.9, 51.0, and 82.5%; specificity 76.2, 72.4, 69.5, and 89.4%; percentage accuracy 70.0, 64.8, 59.9, and 85.2%; positive predictive value 75.2, 69.8, 64.9, and 92.7%, respectively. The categories of CMT reactions were strongly correlated with SCC (P < 0.05). Kappa value of SCC was higher than that of other tests (SCC>CMT>WST>SFMT). Thus, CMT was concluded to be the most accurate (r = 0.782) field diagnostic test after laboratory test like SCC (r = 0.924). However, the use of any single test may not be reliable in diagnosing SCM, while the result of CMT supported by SCC might be used effectively to pinpoint diagnosis of SCM in dairy animals than alone.

Diagnosing intramammary infections: evaluation of definitions based on a single milk sample.

PubMed

Dohoo, I R; Smith, J; Andersen, S; Kelton, D F; Godden, S

2011-01-01

Criteria for diagnosing intramammary infections (IMI) have been debated for many years. Factors that may be considered in making a diagnosis include the organism of interest being found on culture, the number of colonies isolated, whether or not the organism was recovered in pure or mixed culture, and whether or not concurrent evidence of inflammation existed (often measured by somatic cell count). However, research using these criteria has been hampered by the lack of a "gold standard" test (i.e., a perfect test against which the criteria can be evaluated) and the need for very large data sets of culture results to have sufficient numbers of quarters with infections with a variety of organisms. This manuscript used 2 large data sets of culture results to evaluate several definitions (sets of criteria) for classifying a quarter as having, or not having an IMI by comparing the results from a single culture to a gold standard diagnosis based on a set of 3 milk samples. The first consisted of 38,376 milk samples from which 25,886 triplicate sets of milk samples taken 1 wk apart were extracted. The second consisted of 784 quarters that were classified as infected or not based on a set of 3 milk samples collected at 2-d intervals. From these quarters, a total of 3,136 additional samples were evaluated. A total of 12 definitions (named A to L) based on combinations of the number of colonies isolated, whether or not the organism was recovered in pure or mixed culture, and the somatic cell count were evaluated for each organism (or group of organisms) with sufficient data. The sensitivity (ability of a definition to detect IMI) and the specificity (Sp; ability of a definition to correctly classify noninfected quarters) were both computed. For all species, except Staphylococcus aureus, the sensitivity of all definitions was <90% (and in many cases<50%). Consequently, if identifying as many existing infections as possible is important, then the criteria for considering a quarter positive should be a single colony (from a 0.01-mL milk sample) isolated (definition A). With the exception of "any organism" and coagulase-negative staphylococci, all Sp estimates were over 94% in the daily data and over 97% in the weekly data, suggesting that for most species, definition A may be acceptable. For coagulase-negative staphylococci, definitions B (2 colonies from a 0.01-mL milk sample) raised the Sp to 92 and 95% in the daily and weekly data, respectively. For "any organism," using definition B raised the Sp to 88 and 93% in the 2 data sets, respectively. The final choice of definition will depend on the objectives of study or control program for which the sample was collected. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Distributed Bragg Reflectors With Reduced Optical Absorption

DOEpatents

Klem, John F.

2005-08-16

A new class of distributed Bragg reflectors has been developed. These distributed Bragg reflectors comprise interlayers positioned between sets of high-index and low-index quarter-wave plates. The presence of these interlayers is to reduce photon absorption resulting from spatially indirect photon-assisted electronic transitions between the high-index and low-index quarter wave plates. The distributed Bragg reflectors have applications for use in vertical-cavity surface-emitting lasers for use at 1.55 .mu.m and at other wavelengths of interest.

Joint Force Quarterly. Issue 75, 4th Quarter, October 2014

DTIC Science & Technology

2014-10-01

deployment and retrograde as Operation Enduring Freedom winds down. Manning has varied in step with movement tempo, from the initial cadre of 42 to a high...Additionally, T.X. Hammes of the National Defense University pro- motes a distant blockade of China that “establishes a set of concentric rings that denies...Development (USAID) for construction of the Ring Road because it was deemed a “vital economic trade link” and a “key component to stability and

The AMTEX Partnership{trademark}. First quarter report, Fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-01

The AMTEX Partnership is a collaborative research and development program among the US Integrated Textile Industry, DOE, the National Laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating US jobs. Topics in this quarters report include: computer-aided fabric evaluation, cotton biotechnology, demand activated manufacturing architecture, electronic embedded fingerprints, on-line process control in flexible fiber manufacturing, rapid cutting, sensors for agile manufacturing, and textile resource conservation.

Small Caliber Lethality: 5.56mm Performance in Close Quarters Battle. WSTIAC Quarterly, Volume 8, Number 1

DTIC Science & Technology

2008-01-01

occurs to the target. In the end, “foot- pounds of energy” is misleading, “stopping power” is a myth, and the “ oneshot drop” is a rare possibility...Crane, IN, (NSWC- Crane) and the Army’s Armaments Research , Development, and Engineering Center (ARDEC) at Picatinny Arsenal, NJ, pro- duced...still had differences that could not initially be explained. The IPT was ultimately able to determine a reason for the dif- ferences. The Army Research

Lawrence Livermore National Laboratory safeguards and security quarterly progress report to the US Department of Energy quarter ending September 30, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

1994-10-01

This report presents the details of the Lawrence Livermore National Laboratory safeguards and securities program. This program is focused on developing new technology, such as x- and gamma-ray spectrometry, for measurement of special nuclear materials. This program supports the Office of Safeguards and Securities in the following five areas; safeguards technology, safeguards and decision support, computer security, automated physical security, and automated visitor access control systems.

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

Idaho National Laboratory Quarterly Occurrence Analysis 4th Quarter FY 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth Ann

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System, as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 84 reportable events (29 from the 4th quarter fiscal year 2016 and 55 from the prior three reporting quarters), as well as 39 other issue reports (including events found to be not reportable and Significant Category A and Bmore » conditions) identified at INL during the past 12 months (two from this quarter and 37 from the prior three quarters).« less

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

This quarterly report summarizes the status for the project planning to initiate all the legal and contract documents required for establishing the subcontracts needed and a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). During the first quarter (10/1/2012 to 12/31/2012), the statements of work (SOW) for the subcontracts to Purdue University, University of Illinois, and PlastiComp, Inc. were completed. A draft of the CRADA SOW was sent to Autodesk, Toyota, and Magna for technical and legal reviews. PNNL Legal Services contacted project partners’more » Legal counterparts for preparing legal documents for the project. A non-disclosure agreement was drafted and sent to all the parties for reviews.« less

Quarterly environmental data summary for first quarter 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the first quarter of 1999 is enclosed. The data presented in this constitute the QEDS. The data, except for air monitoring data and site KPA generated data (uranium analyses), were received from the contract laboratories, verified by the Weldon Spring Site verification group and merged into the database during the first quarter of 1999. KPA results for on-site total uranium analyses performed during first quarter 1999 are included. Air monitoring data presented are the most recent completemore » sets of quarterly data.« less

78 FR 23903 - Proposed Information Collection; Comment Request; Quarterly Summary of State and Local Government...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-23

... Quarterly Summary of State and Local Government Tax Revenue, using the F-71 (Quarterly Survey of Property Tax Collections), F-72 (Quarterly Survey of State Tax Collections), and F-73 (Quarterly Survey of Non... data for individual states. The information contained in this survey is the most current information...

29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PAY Interpretations Authorized Basic Rates § 548.306 Average earnings for year or quarter year... regular rates of pay during the current quarter year, and (ii) such average hourly remuneration during the... 29 Labor 3 2011-07-01 2011-07-01 false Average earnings for year or quarter year preceding the...

2. View to northeast showing quarters and outbuildings, L to ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. View to northeast showing quarters and outbuildings, L to R: Service Building (HABS No. VA-1287-D), Medical Officer's Quarters C (in background), Garage (HABS No. VA-1287-F), and Medical Officer's Quarters B - Portsmouth Naval Hospital, Medical Officer's Quarters C, West side Williamson Drive, 400 feet South of Rixey Drive, Portsmouth, Portsmouth, VA

Adjustment Notes for Apprentice and Trainee Estimates: December Quarter 2014. Support Document

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2015

2015-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to National Centre for Vocational Education Research (NCVER) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred…

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-14

NASA Technical Reports Server (NTRS)

Bauman, William H.; Crawford, Winifred C.; Watson, Leela R.; Shafer, Jaclyn

2014-01-01

Ms. Crawford completed the final report for the dual-Doppler wind field task. Dr. Bauman completed transitioning the 915-MHz and 50-MHz Doppler Radar Wind Profiler (DRWP) splicing algorithm developed at Marshall Space Flight Center (MSFC) into the AMU Upper Winds Tool. Dr. Watson completed work to assimilate data into model configurations for Wallops Flight Facility (WFF) and Kennedy Space Center/Cape Canaveral Air Force Station (KSC/CCAFS). Ms. Shafer began evaluating the a local high-resolution model she had set up previously for its ability to forecast weather elements that affect launches at KSC/CCAFS. Dr. Watson began a task to optimize the data-assimilated model she just developed to run in real time.

75 FR 4122 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

78 FR 23622 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

78 FR 39823 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

78 FR 76886 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

77 FR 64836 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

76 FR 41320 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

77 FR 1547 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

76 FR 1657 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

77 FR 22057 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

75 FR 17793 - National Small Business Development Center Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... SMALL BUSINESS ADMINISTRATION National Small Business Development Center Advisory Board AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open Federal Advisory Committee meetings... quarter meetings of the National Small Business Development Center (SBDC) Advisory Board. DATES: The...

1. CARRIAGE HOUSE (left) AND SLAVE QUARTERS, SOUTH FRONT. A ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. CARRIAGE HOUSE (left) AND SLAVE QUARTERS, SOUTH FRONT. A kitchen was included in the quarters. - Charles Fraser House, Carriage House & Slave Quarters, 55 King Street, Charleston, Charleston County, SC

EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

2009-02-02

The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

Idaho National Laboratory Quarterly Occurrence Analysis for the 1st Quarter FY2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth Ann

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 82 reportable events (13 from the 1st quarter (Qtr) of fiscal year (FY) 2017 and 68 from the prior three reporting quarters), as well as 31 other issue reports (including events found to be not reportable and Significantmore » Category A and B conditions) identified at INL during the past 12 months (seven from this quarter and 24 from the prior three quarters).« less

Notable deals in the pharmaceutical industry in the first quarter of 2017.

PubMed

Cruces, E

2017-06-01

During the first quarter of 2017, Cortellis Competitive Intelligence had 1,073 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This meant a slight increase on the last quarter (1,022) and a similar volume on the same quarter for the previous 1 year (1,141). However, this quarter showed a significant augment in deals worth more than USD 0.5 billion on the last quarter (17 vs. 12). This article will focus on highlighting a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers. An update on milestone, options and terminated deals of significance will also be presented, along with an early outlook on the next quarter's pharmaceutical licensing activity.

Mycoplasma-induced BALB/c 3T3 collagenase is a mammalian enzyme.

PubMed Central

Kluve, B; Merrick, W C; Gershman, H

1983-01-01

A collagenase previously reported to accumulate in the medium of cultures of BALB/c 3T3 cells on infection with Mycoplasma orale [Kluve, Merrick, Stanbridge & Gershman (1981) Nature (London) 292, 855-857] was partially purified and characterized. With regard to purification properties, activation, sensitivity to inhibitors and relative molecular mass the enzyme was similar to previously reported vertebrate collagenases, but could not be unequivocally distinguished from bacterial collagenases. With regard to substrate-specificity and reaction products, however, the collagenase was typical of vertebrate collagenases and distinct from bacterial collagenases. Specifically, the enzyme displayed a preference for type III collagen and type I collagen, a somewhat decreased ability to degrade type II collagen, and a very limited ability to degrade type IV collagen. The initial products of the action of the collagenase on type I collagen were characterized as fragments one-quarter and three-quarters of the length of the intact collagen molecule. Because the properties of the collagenase produced by cultures of mycoplasma-infected BALB/c 3T3 cells are those of a mammalian-type (vertebrate-type) enzyme, we have concluded that the collagenase is a product of the mouse (BALB/c 3T3) genome, and is not produced by the mycoplasma. Therefore it appears that infection of BALB/c 3T3 mouse fibroblasts with Mycoplasma orale induces the mouse cells to produce and secrete collagenase. PMID:6309150

QUARTERLY TECHNICAL PROGRESS REPORT, JULY, AUGUST, SEPTEMBER 1967.

DTIC Science & Technology

Contents: Circuit research program; Hardware systems research; Computer system software research; Illinois pattern recognition computer: ILLIAC II... service , use, and program development; IBM 7094/1401 service , use, and program development; Problem specifications; General laboratory information.

Adjustment Notes for Apprentice and Trainee Estimates: December Quarter 2016. Support Document

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2017

2017-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to NCVER on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred to as Collection 2, Collection 3 and so on. NCVER…

Adjustment Notes for Apprentice and Trainee Estimates: September Quarter 2016. Support Document

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2017

2017-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to NCVER on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred to as Collection 2, Collection 3 and so on. NCVER…

Expedition 8 Launch Briefing

NASA Image and Video Library

2003-10-12

Expedition 8 Commander and NASA Science Officer Michael Foale talks to a colleague on his cell phone from his crew quarters at the Cosmonaut Hotel in Baikonur, Kazakhstan, Wednesday, Oct. 15, 2003. Foale along with Expedition 8 Soyuz Commander Alexander Kaleri and European Space Agency astronaut Pedro Duuque of Spain, launched on a Soyuz TMA-3 vehicle to the International Space Station. Photo Credit (NASA/Bill Ingalls)

H-division quarterly report, October--December 1977. [Lawrence Livermore Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-02-10

The Theoretical EOS Group develops theoretical techniques for describing material properties under extreme conditions and constructs equation-of-state (EOS) tables for specific applications. Work this quarter concentrated on a Li equation of state, equation of state for equilibrium plasma, improved ion corrections to the Thomas--Fermi--Kirzhnitz theory, and theoretical estimates of high-pressure melting in metals. The Experimental Physics Group investigates properties of materials at extreme conditions of pressure and temperature, and develops new experimental techniques. Effort this quarter concerned the following: parabolic projectile distortion in the two-state light-gas gun, construction of a ballistic range for long-rod penetrators, thermodynamics and sound velocities inmore » liquid metals, isobaric expansion measurements in Pt, and calculation of the velocity--mass profile of a jet produced by a shaped charge. Code development was concentrated on the PELE code, a multimaterial, multiphase, explicit finite-difference Eulerian code for pool suppression dynamics of a hypothetical loss-of-coolant accident in a nuclear reactor. Activities of the Fluid Dynamics Group were directed toward development of a code to compute the equations of state and transport properties of liquid metals (e.g. Li) and partially ionized dense plasmas, jet stability in the Li reactor system, and the study and problem application of fluid dynamic turbulence theory. 19 figures, 5 tables. (RWR)« less

Inorganic pyrophosphatases of Family II-two decades after their discovery.

PubMed

Baykov, Alexander A; Anashkin, Viktor A; Salminen, Anu; Lahti, Reijo

2017-10-01

Inorganic pyrophosphatases (PPases) convert pyrophosphate (PP i ) to phosphate and are present in all cell types. Soluble PPases belong to three nonhomologous families, of which Family II is found in approximately a quarter of prokaryotic organisms, often pathogenic ones. Each subunit of dimeric canonical Family II PPases is formed by two domains connected by a flexible linker, with the active site located between the domains. These enzymes require both magnesium and a transition metal ion (manganese or cobalt) for maximal activity and are the most active (k cat ≈ 10 4 s -1 ) among all PPase types. Catalysis by Family II PPases requires four metal ions per substrate molecule, three of which form a unique trimetal center that coordinates the nucleophilic water and converts it to a reactive hydroxide ion. A quarter of Family II PPases contain an autoinhibitory regulatory insert formed by two cystathionine β-synthase (CBS) domains and one DRTGG domain. Adenine nucleotide binding either activates or inhibits the CBS domain-containing PPases, thereby tuning their activity and, hence, PP i levels, in response to changes in cell energy status (ATP/ADP ratio). © 2017 Federation of European Biochemical Societies.

Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye

PubMed Central

Smith, Justine R.; Todd, Shawn; Ashander, Liam M.; Charitou, Theodosia; Ma, Yuefang; Yeh, Steven; Crozier, Ian; Michael, Michael Z.; Appukuttan, Binoy; Williams, Keryn A.; Lynn, David J.; Marsh, Glenn A.

2017-01-01

Purpose Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level primarily to blockade the host cell type I interferon (IFN) antiviral response. Most individuals who survive Ebola virus disease (EVD) develop a chronic disease syndrome: approximately one-quarter of survivors suffer from uveitis, which has been associated with presence of EBOV within the eye. Clinical observations of post-Ebola uveitis indicate involvement of retinal pigment epithelial cells. Methods We inoculated ARPE-19 human retinal pigment epithelial cells with EBOV, and followed course of infection by immunocytochemistry and measurement of titer in culture supernatant. To interrogate transcriptional responses of infected cells, we combined RNA sequencing with in silico pathway, gene ontology, transcription factor binding site, and network analyses. We measured infection-induced changes of selected transcripts by reverse transcription-quantitative polymerase chain reaction. Results Human retinal pigment epithelial cells were permissive to infection with EBOV, and supported viral replication and release of virus in high titer. Unexpectedly, 28% of 560 upregulated transcripts in EBOV-infected cells were type I IFN responsive, indicating a robust type I IFN response. Following EBOV infection, cells continued to express multiple immunomodulatory molecules linked to ocular immune privilege. Conclusions Human retinal pigment epithelial cells may serve as an intraocular reservoir for EBOV, and the molecular response of infected cells may contribute to the persistence of live EBOV within the human eye. Translational Relevance This bedside-to-bench research links ophthalmic findings in survivors of EVD who suffer from uveitis with interactions between retinal pigment epithelial cells and EBOV. PMID:28721309

Notable licensing deals in the biopharma industry in the second quarter of 2017.

PubMed

D'Souza, P

2017-08-01

During the second quarter of 2017, Cortellis Competitive Intelligence added 967 new licensing deals (excluding mergers and acquisition deals) as part of its ongoing coverage of pharmaceutical licensing activity. This meant an 8% decrease on the previous quarter (1,050) and a 3% decrease from the same quarter in 2016 (993). This quarter also showed a significant decline in the number of deals worth more than USD 0.5 billion from the last quarter (7 vs. 17). This article will highlight a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers in the life sciences. An update on milestone, options and terminated deals of significance will also be presented, along with an early outlook on the next quarter's pharmaceutical licensing activity.

AR and TD Fossil Energy Materials Program. Quarterly progress report for the period ending December 31, 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-04-01

The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1982-1986 in which projects are organized according to fossil energy technologies. This report is divided into parts and chapters with each part describing projects related to a particular fossil energy technology. Chapters within a part provide details of the various projects associated with that technology.more » We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program. Plans for the program will be issued annually. A draft of the program plan for FY 1982 to 1986 has been prepared and is in the review process. The implementation of these plans will be reflected by these quarterly progress reports, and this dissemination of information will bw augmented by topical or final reports as appropriate.« less

Silicon web process development

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Blais, P. D.; Davis, J. R., Jr.

1977-01-01

Thirty-five (35) furnace runs were carried out during this quarter, of which 25 produced a total of 120 web crystals. The two main thermal models for the dendritic growth process were completed and are being used to assist the design of the thermal geometry of the web growth apparatus. The first model, a finite element representation of the susceptor and crucible, was refined to give greater precision and resolution in the critical central region of the melt. The second thermal model, which describes the dissipation of the latent heat to generate thickness-velocity data, was completed. Dendritic web samples were fabricated into solar cells using a standard configuration and a standard process for a N(+) -P-P(+) configuration. The detailed engineering design was completed for a new dendritic web growth facility of greater width capability than previous facilities.

42 CFR 433.10 - Rates of FFP for program services.

Code of Federal Regulations, 2013 CFR

2013-10-01

...; (B) 95 percent, for calendar quarters in CY 2017; (C) 94 percent, for calendar quarters in CY 2018... quarters in CY 2018; and (F) 100 percent, for calendar quarters in CY 2019 and all subsequent calendar...

Experimental intramammary inoculation with Mycoplasma bovis in vaccinated and unvaccinated cows: effect on milk production and milk quality.

PubMed Central

Boothby, J T; Jasper, D E; Thomas, C B

1986-01-01

The effect of vaccination on milk production was evaluated in vaccinated and control cows experimentally challenged in two of four quarters with live Mycoplasma bovis. During the first three weeks after experimental challenge, six of eight unchallenged quarters on vaccinated cows and seven of eight unchallenged quarters on control cows became infected. Most of these quarters secreted normal milk, with negative California Mastitis Test scores and maintained normal milk production throughout most of the study (although some quarters on control cows remained infected). All challenged quarters became infected, had strong California Mastitis Test reactions, and had a drastic (greater than 85%) loss in milk production. Thereafter, four of eight challenged quarters on control cows remained infected, had mostly positive California Mastitis Test scores, produced mostly normal-appearing milk, and recovered some productive capabilities. By the end of the study no M. bovis could be recovered from challenged quarters on vaccinated cows and the milk appeared mostly normal. The California Mastitis Test scores on these quarters, however, remained elevated and milk production remained very low. PMID:3756674

Stress-intensity factor equations for cracks in three-dimensional finite bodies

NASA Technical Reports Server (NTRS)

Newman, J. C., Jr.; Raju, I. S.

1981-01-01

Empirical stress intensity factor equations are presented for embedded elliptical cracks, semi-elliptical surface cracks, quarter-elliptical corner cracks, semi-elliptical surface cracks at a hole, and quarter-elliptical corner cracks at a hole in finite plates. The plates were subjected to remote tensile loading. Equations give stress intensity factors as a function of parametric angle, crack depth, crack length, plate thickness, and where applicable, hole radius. The stress intensity factors used to develop the equations were obtained from three dimensional finite element analyses of these crack configurations.

Turbodrilling performance offshore Qatar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rana, L.A.; Abdulrahman, E.A.

Until the first quarter of 1979 Qatar General Petroleum Corporation Offshore routinely rotary drilled its vertical development wells using tricone bits. Turbodrilling the 17 1/2'' and 8 1/2'' hole sections was introduced in the second quarter of 1979 followed by the 12 1/4'' hole section in the first qarter of 1980. This resulted in avoiding/minimising downhole problems and the elimination of 7'' and 4 1/2'' liners. As a result of introducing these practices a 50 percent time saving and a 30 percent cost saving has been achieved, equivalent to $550,000/well.

Next Generation Transport Phenomenology Model

NASA Technical Reports Server (NTRS)

Strickland, Douglas J.; Knight, Harold; Evans, J. Scott

2004-01-01

This report describes the progress made in Quarter 3 of Contract Year 3 on the development of Aeronomy Phenomenology Modeling Tool (APMT), an open-source, component-based, client-server architecture for distributed modeling, analysis, and simulation activities focused on electron and photon transport for general atmospheres. In the past quarter, column emission rate computations were implemented in Java, preexisting Fortran programs for computing synthetic spectra were embedded into APMT through Java wrappers, and work began on a web-based user interface for setting input parameters and running the photoelectron and auroral electron transport models.

ON THE BIRTH AND DEVELOPMENT OF PSYCHOANALYTIC FIELD THEORY, PART 2.

PubMed

Silverman, Martin A

2017-10-01

Advances in Contemporary Psychoanalytic Field Theory: Concept and Further Development. Edited by S. Montana Katz, Roosevelt Cassorla, and Giuseppe Civitarese. London/New York: Routledge, 2017. 212 pp. © 2017 The Psychoanalytic Quarterly, Inc.

Pertussis, pertussis vaccine, and care of exposed persons.

PubMed

Zimmerman, R K; Wald, E R; Ahwesh, E R

1996-01-01

Pertussis is a highly contagious bacterial infection caused by Bordetella pertussis. Before routine vaccination against pertussis was available, most persons were infected during childhood. After widespread vaccination, however, the incidence of pertussis in the United States dropped by more than 95 percent, though localized outbreaks continue to occur. A multidisciplinary team developed a set of review articles as part of continuing medical education modules in the Teaching Immunization in Medical Education (TIME) Project. The team developed the materials using expert judgment and selected materials from the literature and the Centers for Disease Control and Prevention (CDC). The first step was the creation of specific learning objectives that used the spectrum of Bloom's taxonomy, when possible. After the materials were developed, they were pilot-tested and revised. Subsequently they underwent summative evaluation by field-testing the materials with 24 other primary care physicians. Then the materials were reviewed by the CDC and national vaccine experts and revised based on their comments. The efficacy of whole-cell pertussis vaccine is about 70 to 90 percent, though local adverse events are common. Since 1990 several purified, acellular pertussis vaccines have been developed that have one quarter to one half of the common adverse events associated with whole-cell vaccine and have similar efficacy rates. The incidence of pertussis can be further reduced by increasing age-appropriate vaccination rates.

Practice and Research in Career Counseling and Development--2011

ERIC Educational Resources Information Center

Erford, Bradley T.; Crockett, Stephanie A.

2012-01-01

"The Career Development Quarterly" celebrated its 100th anniversary during the past year and continues to provide high-quality research and conceptual articles of import to the study of career development and intervention. This article reviews the 2011 career counseling and development literature to highlight advances in theory, assessment, and…

Cutaway View of Skylab Orbital Workshop

NASA Technical Reports Server (NTRS)

1972-01-01

This illustration is a cutaway view of the Orbital Workshop (OWS) showing details of the living and working quarters. The OWS was divided into two major compartments. The lower level provided crew accommodations for sleeping, food preparation and consumption, hygiene, waste processing and disposal, and performance of certain experiments. The upper level consisted of a large work area and housed water storage tanks, a food freezer, storage vaults for film, scientific airlocks, mobility and stability experiment equipment, and other experimental equipment . The compartment below the crew quarters was a container for liquid and solid waste and trash accumulated throughout the mission. A solar array, consisting of two wings covered on one side with solar cells, was mounted outside the workshop to generate electrical power to augment the power generated by another solar array mounted on the solar observatory. Thrusters were provided at one end of the workshop for short-term control of the attitude of the space station.

1. GENERAL VIEW OF SLAVE QUARTERS No. 2 (right). Located ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF SLAVE QUARTERS No. 2 (right). Located north of main house. The building at left is Slave Quarters No. 1 (HABS No. VA-1233 C) - Westend, Slave Quarters No. 2, Route 638 vicinity, Trevilians, Louisa County, VA

Idaho National Laboratory Quarterly Occurrence Analysis - 3rd Quarter FY-2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth Ann

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (23 from the 3rd Qtr FY-16 and 50 from the prior three reporting quarters), as well as 45 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (16 from this quarter and 29 from the prior three quarters).« less

Idaho National Laboratory Quarterly Occurrence Analysis - 1st Quarter FY 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth Ann

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 74 reportable events (16 from the 1st Qtr FY-16 and 58 from the prior three reporting quarters), as well as 35 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (15 from this quarter and 20 from the prior three quarters).« less

Development of critical dimension measurement scanning electron microscope for ULSI (S-8000 series)

NASA Astrophysics Data System (ADS)

Ezumi, Makoto; Otaka, Tadashi; Mori, Hiroyoshi; Todokoro, Hideo; Ose, Yoichi

1996-05-01

The semiconductor industry is moving from half-micron to quarter-micron design rules. To support this evolution, Hitachi has developed a new critical dimension measurement scanning electron microscope (CD-SEM), the model S-8800 series, for quality control of quarter- micron process lines. The new CD-SEM provides detailed examination of process conditions with 5 nm resolution and 5 nm repeatability (3 sigma) at accelerating voltage 800 V using secondary electron imaging. In addition, a newly developed load-lock system has a capability of achieving a high sample throughput of 20 wafers/hour (5 point measurements per wafer) under continuous operation. To support user friendliness, the system incorporates a graphical user interface (GUI), an automated pattern recognition system which helps locating measurement points, both manual and semi-automated operation, and user-programmable operating parameters.

Technology today : volume 28, issue 4.

DOT National Transportation Integrated Search

2014-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 26, issue 1.

DOT National Transportation Integrated Search

2011-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 28, issue 3.

DOT National Transportation Integrated Search

2014-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 27, issue 4.

DOT National Transportation Integrated Search

2013-01-01

Technology Today is a quarterly : publication of the Louisiana Transportation : Research Center, administered jointly : by the Louisiana Department of : Transportation and Development and : Louisiana State University.

Technology today : volume 28, issue 1.

DOT National Transportation Integrated Search

2013-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 29, issue 1.

DOT National Transportation Integrated Search

2014-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 25, issue 3.

DOT National Transportation Integrated Search

2011-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : volume 29 issue 4.

DOT National Transportation Integrated Search

2015-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Mastitis diagnosis in dairy cows using PathoProof real-time polymerase chain reaction assay in comparison with conventional bacterial culture in a Northern German field study.

PubMed

Spittel, Susanne; Hoedemaker, Martina

2012-01-01

In the following field study, the commercial PathoProof Mastitis PCR Assay, a real-time PCR for identifying eleven mastitis pathogens and the staphylococcal beta-lactamase gene, was compared with conventional bacterial culture. For this purpose, 681 udder quarter samples from 173 clinically healthy cows with varying somatic cell count from four dairy herds in the region of Osnabrück, Lower Saxony, Germany, were collected between July 2010 and February 2011 and subjected to PCR and bacterial culture. The frequency of positive pathogen signals was markedly higher with PCR compared with culture (70.6% vs. 32.2%). This was accompanied by a substantial higher percentage of multiple pathogen identifications and a lower percentage of single identifications in the PCR compared with bacterial culture. Using bacterial culture as gold standard, moderate to high sensitivities (76.9-100%) and specificities (63.3-98.7%) were calculated for six out of seven pathogens with sufficient detection numbers. For Enterococcus spp, the sensitivity was only 9.1%. When the PCR results of pooled udder quarter samples of the 173 cows were compared with the single udder quarter samples, in 72% of the cases, major pathogen DNA was either not found in both types of samples, or in the case of a positive pool sample, the respective pathogens were found in at least one udder quarter sample. With both methods, the most frequently detected mastitis pathogens were coryneform bacteria (PCR: Corynebacterium bovis), coagulase-negative staphylococci (CNS) and Staphylococcus (S.) aureus, followed by Arcanobacterium pyogenes/Peptoniphilus indolicus with PCR, and then with both methods, Streptococcus uberis. The staphylococcal beta-lactamase gene was found in 27.7% of the S. aureus and in 37.0% of the CNS identifications.

77 FR 51705 - Rescission of Quarterly Financial Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... No. FMCSA-2012-0020] RIN-2126-AB48 Rescission of Quarterly Financial Reporting Requirements AGENCY...: FMCSA withdraws its June 27, 2012, direct final rule eliminating the quarterly financial reporting... future proposing the elimination of the quarterly financial reporting requirements for Form QFR and Form...

Teaching Physics and Feeling Good about It.

ERIC Educational Resources Information Center

Prokop, Charles F.

1988-01-01

Describes a high school physics teaching sequence including more modern topics. The first quarter covers cosmology, astronomy, optics, wave mechanics, relativity, gravity, and quantum theory. The second quarter covers classical mechanics. The third quarter covers electromagnetism and electronics. The fourth quarter consists of thermodynamics and…

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

77 FR 39447 - Revisions to Electric Quarterly Report Filing Process

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... Quarterly Report Filing Process AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Notice of... Rule which governs the filing of Electric Quarterly Reports (EQRs), to change the process for filing... Regulatory Commission (Commission) proposes changes to the method for filing Electric Quarterly Reports (EQRs...

75 FR 12777 - Notice of Regulatory Waiver Requests Granted for the Fourth Quarter of Calendar Year 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... Development Initiative Special Project (EDI-SP) funds to implement the Pagedale Community Development... are currently vacant. Subsequent to the March 11, 2009 appropriation containing the EDI-SP, but prior...

Effect of pre-milking teat disinfection on new mastitis infection rates of dairy cows.

PubMed

Gleeson, David; Flynn, Jimmy; Brien, Bernadette O'

2018-01-01

The practise of teat disinfection prior to cluster attachment for milking is being adopted by farmers in Ireland, particularly where there are herd issues with new infection rates. Pre-milking teat disinfection has been shown to reduce bacterial numbers on teat skin and to be most effective against environmental bacteria such as Escherichia coli and Streptococcus uberis. A split udder design experiment was undertaken on two research herds (A = 96 cows: B = 168 cows) to test the benefit of pre-milking teat disinfection on new mastitis infection levels. The disinfectant was applied to the left front and right hind teats of all cows in each herd and the right front and left hind teats received no disinfectant treatment prior to milking over a complete lactation. Individual quarter foremilk samples were taken on 5 occasions during the lactation and all clinical cases were recorded. The presence and number of staphylococcus and streptococcus bacteria on teat skin of a random sample of experimental cows ( n  = 20) was measured on 3 occasions during lactation (April, June, and October). Pre-milking teat disinfection had no significant impact on quarter SCC and new infection rates ( P  > 0.05). The median SCC was 169 (95% CI = 144-198) × 10 3 cells/mL and 170 (95% CI = 145-199) × 10 3 cells/mL for disinfected teats and non-disinfected teats, respectively. There were no differences in SCC observed between herds (A = 161 (95% CI = 127-205) × 10 3 cells/mL; B = 169 (95% CI = 144-198) × 10 3 cells/mL) over the complete lactation. Bacterial levels on teat skin were reduced significantly with pre-milking teat disinfection compared to teats receiving no disinfectant ( P  < 0.001). Total infections (clinical and sub-clinical) were similar for disinfected teats ( n  = 36) and not disinfected teats ( n  = 40), respectively. Staphylococcus aureus ( n  = 47) and Strep. uberis ( n  = 9) were identified as the predominant bacteria in quarter foremilk samples with both clinical and sub-clinical infections. SCC and new infection rates were similar in non-disinfected teats and disinfected (pre-milking) teats. The routine application of pre-milking teat disinfectant in pasture-grazed herds is unlikely to be of benefit where herd SCC is below 200 × 10 3 cells/mL.

STUDY ON THE MECHANICAL WORKING CONDITIONS OF NUCLEAR MATERIALS AS RELATED TO ROLLING. Quarterly Report No. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vidal, C.A.M.; Sabato, J.A.

1962-09-01

BS>Descriptions are given of: (a) the design, construction, and adjustment of a Ford plane-strain compression die, to be used in the determination of constrained yield stress curves, and (b) the design and construction of a load cell with strain gages to be used in the measurement of the rolling load during rolling. (auth)

Tulane/Xavier University hazardous materials in aquatic environments of the Mississippi River basin. Quarterly progress report, January 1--March 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-05-17

The objectives of this report are to provide the necessary administrative support to assure that the scientific and educational goals of the project are obtained and to assure that all Department of Energy reporting requirements and requests are fulfilled. The grant reporting is divided into three aspects: Collaborative Cluster projects, Initiation projects and Education projects. A cluster project is one or more closely related collaborative, multidisciplinary research projects in which a group of investigators employs a synergistic approach to the solution of problems in the same general area of research. The accomplishments this quarter of eleven cluster projects are presented.more » An initial project typically involves a single investigator. The purpose of the project is to undertake pilot work, lasting no more than one year, which will lead to the successful submission of an externally-funded proposal or the development of a collaborative cluster project. The accomplishments this quarter of eleven initiation projects are presented. The education projects are designed to develop courses with emphasis on environmental studies and/or to train students in areas of environmental research.« less

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2010 CFR

2010-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and on GPO...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2010 CFR

2010-01-01

... RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly physical inventory to account for all sealed sources and for devices containing depleted uranium received... 10 Energy 1 2010-01-01 2010-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR...

19 CFR 159.34 - Certified quarterly rate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.34 Certified quarterly rate. (a) Countries for which quarterly rate is certified. For the currency of each of the following... York for such foreign currency for a day in that quarter: Australia, Austria, Belgium, Brazil, Canada...

78 FR 59093 - Quarterly Rail Cost Adjustment Factor

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

...)] Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2013 rail cost adjustment factor (RCAF) and cost index filed by the Association of American Railroads. The fourth quarter 2013 RCAF...

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2011 CFR

2011-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2012 CFR

2012-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

Pathogen group specific risk factors for clinical mastitis, intramammary infection and blind quarters at the herd, cow and quarter level in smallholder dairy farms in Jimma, Ethiopia.

PubMed

Tolosa, T; Verbeke, J; Ayana, Z; Piepers, S; Supré, K; De Vliegher, S

2015-07-01

A cross-sectional study on clinical mastitis, intramammary infection (IMI) and blind quarters was conducted on 50 smallholder dairy farms in Jimma, Ethiopia. A questionnaire was performed, and quarters of 211 cows were sampled and bacteriologically cultured. Risk factors at the herd, cow, and quarter level for clinical mastitis and (pathogen-specific) intramammary infection were studied using multilevel modeling. As well, factors associated with quarters being blind were studied. Eleven percent of the cows and 4% of the quarters had clinical mastitis whereas 85% of the cows and 51% of the quarters were infected. Eighteen percent of the cows had one or more blind quarter(s), whereas 6% of the quarters was blind. Non-aureus staphylococci were the most frequently isolated pathogens in both clinical mastitis cases and IMI. The odds of clinical mastitis was lower in herds where heifers were purchased in the last year [odds ratio (OR) with 95% confidence interval: 0.11 (0.01-0.90)], old cows (>4 years) [OR: 0.45 (0.18-1.14)], and quarters not showing teat injury [OR: 0.23 (0.07-0.77)]. The odds of IMI caused by any pathogen was higher in herds not practicing teat drying before milking (opposed to drying teats with 1 towel per cow) [OR: 1.68 (1.05-2.69)], cows in later lactation (>180 DIM opposed to ≤90 DIM) [OR: 1.81 (1.14-2.88)], cows with a high (>3) body condition score (BCS) [OR: 1.57 (1.06-2.31)], right quarters (opposed to a left quarter position) [OR: 1.47 (1.10-1.98)], and quarters showing teat injury [OR: 2.30 (0.97-5.43)]. Quarters of cows in herds practicing bucket-fed calf feeding (opposed to suckling) had higher odds of IMI caused by Staphylococcus aureus [OR: 6.05 (1.31-27.90)]. Except for BCS, IMI caused by non-aureus staphylococci was associated with the same risk factors as IMI caused by any pathogen. No access to feed and water immediately after milking [OR: 2.41 (1.26-4.60)], higher parity [OR: 3.60 (1.20-10.82)] and tick infestation [OR: 2.42 (1.02-5.71)] were risk factors for quarters being blind. In conclusion, replacement of old cows, prevention of teat injuries/lesions, drying teats with 1 towel per cow before milking, improving fertility in order to shorten the lactation period, allowing (restricted) suckling, access to feed and water immediately after milking, and improving tick control could improve udder health in Jimma. Copyright © 2015 Elsevier B.V. All rights reserved.

10 CFR 34.69 - Records of quarterly inventory.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INDUSTRIAL RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.69 Records of quarterly inventory. (a) Each licensee shall maintain records of the quarterly inventory of sealed sources and of devices... 10 Energy 1 2010-01-01 2010-01-01 false Records of quarterly inventory. 34.69 Section 34.69 Energy...

77 FR 27021 - Proposed Information Collection; Comment Request; Quarterly Survey of Financial Services...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... Request; Quarterly Survey of Financial Services Transactions Between U.S. Financial Services Providers [email protected] . SUPPLEMENTARY INFORMATION: I. Abstract Form BE-185, Quarterly Survey of Financial Services Transactions between U.S. Financial Services Providers and Foreign Persons, obtains quarterly data from U.S...

Commercial space and launch insurance : current market and future outlook : fourth quarter 2002 Quarterly Launch Report

DOT National Transportation Integrated Search

2002-01-01

Since the last review of the space and launch insurance industry (see "Update of the Space and Launch Insurance Industry," 4th quarter, : 1998 Quarterly Launch Report), many changes have occurred in the market. This report endeavors to examine the cu...

39 CFR 3050.25 - Volume and revenue data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... billing determinants, broken out by quarter, within 90 days of the close of each fiscal year; (c) Revenue, pieces, and weight by rate category and special service by quarter, within 30 days of the close of the quarter; (d) Quarterly Statistics Report, including estimates by shape, weight, and indicia, within 30...

Technology Today, Volume 32, Issue 2, Winter 2018

DOT National Transportation Integrated Search

2018-01-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : Volume 31, Issue 1, Fall 2016.

DOT National Transportation Integrated Search

2016-09-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today, volume 30, issue 4, Summer 2016.

DOT National Transportation Integrated Search

2016-07-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

Technology today : Volume 30 Issue 3, Spring 2016.

DOT National Transportation Integrated Search

2016-03-01

Technology Today is a quarterly publication of the Louisiana Transportation Research Center, administered jointly by the Louisiana Department of Transportation and Development and Louisiana State University.

The susceptibility of bovine udder quarters colonized with Corynebacterium bovis to experimental infection with Staphylococcus aureus or Streptococcus agalactiae.

PubMed Central

Brooks, B W; Barnum, D A

1984-01-01

Twenty bovine udder quarters colonized with Corynebacterium bovis SR6 and 20 uncolonized quarters were challenged by inoculation of Staphylococcus aureus Newbould 305 (ATCC 29740) into the teat cistern. The percentage of infection in quarters colonized with C. bovis (50%) was significantly lower than that in controls (100%). By similar challenge no significant difference was observed between the percentage of infection with Streptococcus agalactiae ATCC 27956 in 33 quarters colonized with C. bovis (70%) compared to 33 controls (87.9%). A total of 37 quarters colonized with C. bovis and 37 control quarters were challenged with Staph. aureus Newbould 305 (ATCC 29740) and Maxi (ATCC 27543) and Strep. agalactiae (ATCC 27956) by exposure of the teat orifice. The percentage of teat ducts colonized with C. bovis which became infected with either pathogen was not different from that for controls. PMID:6372969

Development Communication Report, 1992.

ERIC Educational Resources Information Center

Development Communication Report, 1992

1992-01-01

The four issues of the quarterly newsletter contained in this document focus on the use of communication technologies in developing countries to educate the people about various social issues as well as the field of development communication itself. Environment and communication is the theme of the first issue, which includes articles on…

Estimation of Apprentice and Trainee Statistics. Technical Paper

ERIC Educational Resources Information Center

Harvey, Brian

2010-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to NCVER (National Centre for Vocational Education Research) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred…

75 FR 59279 - Quarterly IRS Interest Rates Used In Calculating Interest On Overdue Accounts and Refunds On...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Quarterly IRS Interest Rates... notice advises the public of the quarterly Internal Revenue Service interest rates used to calculate... quarter beginning October 1, 2010, the interest rates for overpayments will be 3 percent for corporations...

Natural gas imports and exports. Second quarter report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-31

The Office of Natural Gas and Petroleum Import and Export Activities prepares quarterly reports summarizing the data provided by companies authorized to import or export natural gas. Companies are required, as a condition of their authorizations, to file quarterly reports. This report is for the second quarter of 1997 (April through June).

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility as well as each non-public utility with more than a de minimis market presence shall file an updated Electric Quarterly Report with the...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility as well as each non-public utility with more than a de minimis market presence shall file an updated Electric Quarterly Report with the...

77 FR 21969 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... plans to export Chicken leg quarters, (or parts of chicken leg quarters, including legs or thighs..., classifiable under HTS 0207.13.99, 0207.14.99 and 1602.32.00. Export Markets Chicken leg quarters for which... shall offer TRQ Certificates for duty-free shipments of chicken leg quarters to the Republic of Panama...

Estimation of Apprentice and Trainee Statistics. Technical Paper

ERIC Educational Resources Information Center

Harvey, Brian

2009-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to the National Centre for Vocational Education Research (NCVER) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are…

45 CFR 303.108 - Quarterly wage and unemployment compensation claims reporting to the National Directory of New...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Quarterly wage and unemployment compensation... OPERATIONS § 303.108 Quarterly wage and unemployment compensation claims reporting to the National Directory of New Hires. (a) What definitions apply to quarterly wage and unemployment compensation claims...

45 CFR 303.108 - Quarterly wage and unemployment compensation claims reporting to the National Directory of New...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Quarterly wage and unemployment compensation... OPERATIONS § 303.108 Quarterly wage and unemployment compensation claims reporting to the National Directory of New Hires. (a) What definitions apply to quarterly wage and unemployment compensation claims...

45 CFR 303.108 - Quarterly wage and unemployment compensation claims reporting to the National Directory of New...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Quarterly wage and unemployment compensation claims... OPERATIONS § 303.108 Quarterly wage and unemployment compensation claims reporting to the National Directory of New Hires. (a) What definitions apply to quarterly wage and unemployment compensation claims...

45 CFR 303.108 - Quarterly wage and unemployment compensation claims reporting to the National Directory of New...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Quarterly wage and unemployment compensation claims... OPERATIONS § 303.108 Quarterly wage and unemployment compensation claims reporting to the National Directory of New Hires. (a) What definitions apply to quarterly wage and unemployment compensation claims...

45 CFR 303.108 - Quarterly wage and unemployment compensation claims reporting to the National Directory of New...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Quarterly wage and unemployment compensation... OPERATIONS § 303.108 Quarterly wage and unemployment compensation claims reporting to the National Directory of New Hires. (a) What definitions apply to quarterly wage and unemployment compensation claims...

Quarterly Progress Report for the Chemical and Energy Research Section of the Chemical Technology Division: July-September 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jubin, R.T.

2001-04-16

This report summarizes the major activities conducted in the Chemical and Energy Research Section of the Chemical Technology Division at Oak Ridge National Laboratory (ORNL) during the period July-September 1999. The section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within ten major areas of research: Hot Cell Operations, Process Chemistry, Molten Salt Reactor Experiment (MSRE) Remediation Studies, Chemistry Research, Physical Properties Research, Biochemical Engineering, Separations and Materials Synthesis, Fluid Structures andmore » Properties, Biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information. Activities conducted within the area of the Cell Operations involved the testing of two continuously stirred tank reactors in series to evaluate the Savannah River-developed process of small-tank tetraphenylborate precipitation to remove cesium, strontium and transuranics from supernatant. Within the area of Process Chemistry, various topics related to solids formation in process solutions from caustic treatment of Hanford sludge were addressed. Saltcake dissolution efforts continued, including the development of a predictive algorithm. New initiatives for the section included modeling activities centered on detection of hydrogen in {sup 233}U storage wells and wax formation in petroleum mixtures, as well as support for the Spallation Neutron Source (investigation of transmutation products formed during operation). Other activities involved in situ grouting and evaluation of options for use (i.e., as castable shapes) of depleted uranium. In a continuation of activities of the preceding quarter, MSRE Remediation Studies focused on recovery of {sup 233}U and its conversion to a stable oxide and radiolysis experiments to permit remediation of MSRE fuel salt. Investigation of options for final disposition of the {sup 233}U inventory represents a new initiative within this area. In the area of Chemistry Research, activities included studies relative to molecular imprinting for use in areas such as selective sorption, chemical sensing, and catalysis, as well as spectroscopic investigation into the fundamental interaction between ionic solvents and solutes in both low- and high-temperature ionic liquids.« less

A hybrid ARIMA and neural network model applied to forecast catch volumes of Selar crumenophthalmus

NASA Astrophysics Data System (ADS)

Aquino, Ronald L.; Alcantara, Nialle Loui Mar T.; Addawe, Rizavel C.

2017-11-01

The Selar crumenophthalmus with the English name big-eyed scad fish, locally known as matang-baka, is one of the fishes commonly caught along the waters of La Union, Philippines. The study deals with the forecasting of catch volumes of big-eyed scad fish for commercial consumption. The data used are quarterly caught volumes of big-eyed scad fish from 2002 to first quarter of 2017. This actual data is available from the open stat database published by the Philippine Statistics Authority (PSA)whose task is to collect, compiles, analyzes and publish information concerning different aspects of the Philippine setting. Autoregressive Integrated Moving Average (ARIMA) models, Artificial Neural Network (ANN) model and the Hybrid model consisting of ARIMA and ANN were developed to forecast catch volumes of big-eyed scad fish. Statistical errors such as Mean Absolute Errors (MAE) and Root Mean Square Errors (RMSE) were computed and compared to choose the most suitable model for forecasting the catch volume for the next few quarters. A comparison of the results of each model and corresponding statistical errors reveals that the hybrid model, ARIMA-ANN (2,1,2)(6:3:1), is the most suitable model to forecast the catch volumes of the big-eyed scad fish for the next few quarters.

Postanesthetic recumbency associated with hyperkalemic periodic paralysis in a quarter horse.

PubMed

Robertson, S A; Green, S L; Carter, S W; Bolon, B N; Brown, M P; Shields, R P

1992-10-15

Anesthesia and surgery in a Quarter Horse affected with hyperkalemic periodic paralysis resulted in euthanasia after 7 days of postoperative recumbency. Initial recovery was uneventful after extensive sinus surgery, but within 2 hours, the horse had severe muscle weakness. Plasma electrolyte concentrations were within the normal range during the period of recumbency. There was no clinical or laboratory evidence of severe muscle damage. Despite treatment with acetazolamide, isoproterenol, and intensive nursing, the horse was unable to stand for more than a few seconds and developed severe decubital ulcers. Ultrastructural examination revealed nemaline rods and swollen mitochondria in disrupted myofibers.

Sub-clinical mastitis and associated risk factors on lactating cows in the Savannah Region of Nigeria

PubMed Central

2012-01-01

Background Sub-clinical mastitis limits milk production and represents an important barrier to profitable livestock economics worldwide. Milk production from cows in Nigeria is not at optimum levels in view of many factors including sub-clinical mastitis. Results The overall herd-level prevalence rate for SCM was 85.33% (256/300 heads of cows) while the quarter-level prevalence rate of SCM was 43.25% (519/1,200 quarters). The prevalence of SCM was 50.67%, 43.67%, 39.67% and 39.13% for the left fore-quarter, right hind-quarter, left hind-quarter and right fore-quarter, respectively. The Rahaji breed had the highest prevalence of SCM with 65.91% (29/44), while the White Fulani breed had the least with 32.39% (57/176). A total of 32.33% (97/300) had only one mammary quarter affected, 30.33% (91/300) had two quarters affected, 16.00% (48/300) had three quarters affected while 6.67% (20/300) had all the four quarters affected. A total of 53.00% had SCM in multiple quarters (159/300). The risk of SCM decreased significantly among young lactating cows compared to older animals (OR = 0.283; P < 0.001; 95%CI = 0.155; 0.516). The Rahaji breed had significantly higher risk compared with the White Fulani breed (OR = 8.205; P = 0.013; 95% CI = 1.557; 43.226). Improved sanitation (washing hands before milking) will decrease the risk of SCM (OR = 0.173; P = 0.003; 95% CI = 0.054; 0.554). Conclusion SCM is prevalent among lactating cows in the Nigerian Savannah; and this is associated with both animal characteristics (age, breed and individual milk quarters) and milking practices (hand washing).Good knowledge of the environment and careful management of the identified risk factors with improved sanitation should assist farm managers and veterinarians in implementing preventative programmes to reduce the incidence of SCM. PMID:22894639

Inertial Confinement Fusion Annual Report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Correll, D

The ICF Annual Report provides documentation of the achievements of the LLNL ICF Program during the fiscal year by the use of two formats: (1) an Overview that is a narrative summary of important results for the fiscal year and (2) a compilation of the articles that previously appeared in the ICF Quarterly Report that year. Both the Overview and Quarterly Report are also on the Web at http://lasers.llnl.gov/lasers/pubs/icfq.html. Beginning in Fiscal Year 1997, the fourth quarter issue of the ICF Quarterly was no longer printed as a separate document but rather included in the ICF Annual. This change providedmore » a more efficient process of documenting our accomplishments with-out unnecessary duplication of printing. In addition we introduced a new document, the ICF Program Monthly Highlights. Starting with the September 1997 issue and each month following, the Monthly Highlights will provide a brief description of noteworthy activities of interest to our DOE sponsors and our stakeholders. The underlying theme for LLNL's ICF Program research continues to be defined within DOE's Defense Programs missions and goals. In support of these missions and goals, the ICF Program advances research and technology development in major interrelated areas that include fusion target theory and design, target fabrication, target experiments, and laser and optical science and technology. While in pursuit of its goal of demonstrating thermonuclear fusion ignition and energy gain in the laboratory, the ICF Program provides research and development opportunities in fundamental high-energy-density physics and supports the necessary research base for the possible long-term application of inertial fusion energy for civilian power production. ICF technologies continue to have spin-off applications for additional government and industrial use. In addition to these topics, the ICF Annual Report covers non-ICF funded, but related, laser research and development and associated applications. We also provide a short summary of the quarterly activities within Nova laser operations, Beamlet laser operations, and National Ignition Facility laser design. LLNL's ICF Program falls within DOE's national ICF program, which includes the Nova and Beamlet (LLNL), OMEGA (University of Rochester Laboratory for Laser Energetics), Nike (Naval Research Laboratory), and Trident (Los Alamos National Laboratory) laser facilities. The Particle Beam Fusion Accelerator (Z) and Saturn pulsed-power facilities are at Sandia National Laboratories. General Atomics, Inc., develops and provides many of the targets for the above experimental facilities. Many of the ICF Annual Report articles are co-authored with our colleagues from these other ICF institutions.« less

Environmental Hazards Assessment Program. Quarterly report, July--September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This report describes activities and reports on progress for the first quarter (July--September) of the fourth year of the grant to support the Environmental Hazards Assessment Program (EHAP) at the Medical University of South Carolina. It reports progress against the grant objectives and the Program Implementation Plan published at the end of the first year of the grant. The objectives of EHAP stated in the proposal to DOE are to: (1) develop a holistic, national basis for risk assessment, risk management, and risk communication that recognizes the direct impact of environmental hazards on the health and well-being of all; (2)more » develop a pool of talented scientists and experts in cleanup activities, especially in human health aspects; and (3) identify needs and develop programs addressing the critical shortage of well-educated, highly-skilled technical and scientific personnel to address the health-oriented aspects of environmental restoration and waste management.« less

Applied Meteorology Unit Quarterly Report, Second Quarter FY-13

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Shafer, Jaclyn; Huddleston, Lisa

2013-01-01

The AMU team worked on six tasks for their customers: (1) Ms. Crawford continued work on the objective lightning forecast task for airports in east-central Florida, and began work on developing a dual-Doppler analysis with local Doppler radars, (2) Ms. Shafer continued work for Vandenberg Air Force Base on an automated tool to relate pressure gradients to peak winds, (3) Dr. Huddleston continued work to develop a lightning timing forecast tool for the Kennedy Space Center/Cape Canaveral Air Force Station area, (4) Dr. Bauman continued work on a severe weather forecast tool focused on east-central Florida, (5) Mr. Decker began developing a wind pairs database for the Launch Services Program to use when evaluating upper-level winds for launch vehicles, and (6) Dr. Watson began work to assimilate observational data into the high-resolution model configurations, she created for Wallops Flight Facility and the Eastern Range.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Exploration of various types of power plant cycles for nuclear propelled aircraft has been continued during this quarter. The principal current objective of the project is the development of information which will make an intelligent choice of the basic power plant cycle possible. It is still hoped that this choice can be made late in 1950. The survey studies which have been under way for several months continued during the quarter. These consist of analyses and rough preliminary layouts for various types of aircraft, using each of the several basic cycles which have been seriously considered for each of themore » three phases of development. Although it is still extremely premature to discuss the relative merits of the various cycles, the information so for developed discloses some cycle differences which may, if confirmed by additional work, be significant. In this respect, there have been no recent major changes in the comparative standings of the cycles.« less

75 FR 29600 - Occupational Information Development Advisory Panel Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2010-0022] Occupational Information Development Advisory Panel Meeting AGENCY: Social Security Administration (SSA). ACTION: Notice of upcoming quarterly... amended, shall report to the Commissioner of Social Security. The Panel will advise the Agency on creating...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

A collection of quarterly and monthly reports from Elcam, Inc., covering progress made from January 1, 1978, through September 30, 1978, is presented. Elcam, is developing two solar-heated hot water prototype systems and two heat exchangers. This effort consists of development, manufacture, installation, maintenance, problem resolution, and system evaluation.

QUARTERLY TECHNICAL PROGRESS REPORT, JULY, AUGUST, SEPTEMBER 1966.

DTIC Science & Technology

Contents: Circuit research program; Hardware systems research; Software systems research program; Numerical methods, computer arithmetic and...artificial languages; Library automation; Illiac II service , use, and program development; IBM service , use, and program development; Problem specifications; Switching theory and logical design; General laboratory information.

Financial Implications of the Extended School Year.

ERIC Educational Resources Information Center

San Diego Unified School District, CA. Administrative Research Dept.

This report considers the costs of three types of extended school year programs--all modifications of the quarter system--and compares these costs to the regular program. Compared against the traditional approach are: (1) a quarter system in which students attend three quarters a year and are off one quarter, meaning that 75% of all students are…

Estimation of Apprentice and Trainee Statistics. Technical Paper

ERIC Educational Resources Information Center

Harvey, Brian

2010-01-01

Apprentice and trainee data are reported by the state and territory training authorities to the National Centre for Vocational Education and Training (NCVER) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as collection 1. The sets of data submitted in subsequent quarters are…

77 FR 10958 - International Services Surveys: BE-150, Quarterly Survey of Cross-Border Credit, Debit, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

...-Border Credit, Debit, and Charge Card Transactions, to change the survey title, and to collect data in... from Quarterly Survey of Cross-Border Credit, Debit, and Charge Card Transactions to Quarterly Survey... Survey of Cross-Border Credit, Debit, and Charge Card Transactions to Quarterly Survey of Payment Card...

Adjustment Notes for Apprentice and Trainee Estimates. Technical Paper

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2010

2010-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to the National Centre for Vocational Education Research (NCVER) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are…

Adjustment Notes for Apprentice and Trainee Estimates. Technical Paper

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2011

2011-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to NCVER (National Centre for Vocational Education Research) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred…

Adjustment Notes for Apprentice and Trainee Estimates. Technical Paper

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2010

2010-01-01

Apprentice and trainee data are reported by the State and Territory Training Authorities to National Centre for Vocational Education Research (NCVER) on a quarterly basis, starting at the September quarter of 1994. The set of data submitted that quarter is referred to as Collection 1. The sets of data submitted in subsequent quarters are referred…

Consolidated Quarterly Report: Number of potential release sites subject to corrective action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2017-04-01

This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent. The 12 sites in the corrective action process are listed in Table I-1.

Life sciences licensing deals in the fourth quarter of 2017: updates and trends.

PubMed

D'Souza, P

2018-02-01

During the fourth quarter of 2017, Cortellis Competitive Intelligence registered 1,107 new deals (excluding mergers & acquisitions) as part of its ongoing coverage of licensing activity in the life sciences sector compared to 1,043 in the third quarter and 1,035 in the fourth quarter of 2016. Copyright 2018 Clarivate Analytics.

7 CFR Exhibit E to Subpart N of... - Guide For Quarterly Performance Report

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 13 2012-01-01 2012-01-01 false Guide For Quarterly Performance Report E Exhibit E to.... 1944, Subpt. N, Exh. E Exhibit E to Subpart N of Part 1944—Guide For Quarterly Performance Report...: (___% Rate) ___ This Quarter Total ___ B. Use of Program Funds: Budgeted Amount ___ Expended Thru Last...

7 CFR Exhibit E to Subpart N of... - Guide For Quarterly Performance Report

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 13 2013-01-01 2013-01-01 false Guide For Quarterly Performance Report E Exhibit E to.... 1944, Subpt. N, Exh. E Exhibit E to Subpart N of Part 1944—Guide For Quarterly Performance Report...: (___% Rate) ___ This Quarter Total ___ B. Use of Program Funds: Budgeted Amount ___ Expended Thru Last...

7 CFR Exhibit E to Subpart N of... - Guide For Quarterly Performance Report

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 13 2014-01-01 2013-01-01 true Guide For Quarterly Performance Report E Exhibit E to.... 1944, Subpt. N, Exh. E Exhibit E to Subpart N of Part 1944—Guide For Quarterly Performance Report...: (___% Rate) ___ This Quarter Total ___ B. Use of Program Funds: Budgeted Amount ___ Expended Thru Last...

17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

Code of Federal Regulations, 2014 CFR

2014-04-01

... & poor's 500 stock composite index for calendar 1971] Quarterly ending— Index value 1 Quarterly dividend yield-composite index Annual percent 2 Quarterly percent 3 (1/4 of annual)> Dec. 1970 92.15 Mar. 1971... Investment record of Standard & Poor's 500 stock composite index assuming quarterly reinvestment dividends...

76 FR 38383 - Revised Public Utility Filing; Requirements for Electric Quarterly Reports; Notice of Electric...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No.: ER02-2001-000] Revised Public Utility Filing; Requirements for Electric Quarterly Reports; Notice of Electric Quarterly Reports Users Group Meeting This notice announces a meeting of the Electric Quarterly Reports (EQR) Users Group to be held Wednesday, July 13, 2011, in the...

Electric Power Quarterly, July-September 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-01-29

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. The data presented in this report were collected and published by the Energy Information Administration (EIA), to fulfill its responsibilities as specified in the Federal Energy Administration Act of 1974 (P.L. 93-275) as amended. This edition of the EPQ contains monthly data for the third quarter of 1985.

Low cost hydrogen/novel membrane technology for hydrogen separation from synthesis gas, Phase 1. [Polyetherimide, cellulose acetate and ethylcellulose

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-01-01

The goal of this program is to develop polymer membranes useful in the preparation of hydrogen from coal-derived synthesis gas. During this quarter the first experiment were aimed at developing high performance composite membranes for the separation of hydrogen from nitrogen and carbon monoxide. Three polymers have been selected as materials for these membranes: polyetherimide cellulose acetate and ethylcellulose. This quarter the investigators worked on polyetherimide and cellulose acetate membranes. The overall structure of these membranes is shown schematically in Figure 1. As shown, a microporous support membrane is first coated with a high flux intermediate layer then with anmore » ultrathin permselective layer and finally, if necessary, a thin protective high flux layer. 1 fig., 4 tabs.« less

Advanced MHD Algorithm for Solar and Space Science: lst Year Semi Annual Progress Report

NASA Technical Reports Server (NTRS)

Schnack, Dalton D.; Lionello, Roberto

2003-01-01

We report progress for the development of MH4D for the first and second quarters of FY2004, December 29, 2002 - June 6, 2003. The present version of MH4D can now solve the full viscous and resistive MHD equations using either an explicit or a semi-implicit time advancement algorithm. In this report we describe progress in the following areas. During the two last quarters we have presented poster at the EGS-AGU-EUG Joint Assembly in Nice, France, April 6-11, 2003, and a poster at the 2003 International Sherwood Theory Conference in Corpus Christi, Texas, April 28-30 2003. In the area of code development, we have implemented the MHD equations and the semi-implicit algorithm. The new features have been tested.

AFRRI Reports Second Quarter, April-June 1991

DTIC Science & Technology

1991-07-01

chosen after bacteria generally involves the use of aminoglycosides in preliminary data showed that the animals became suscepti- combination with beta ...antibiotic therapy in the febrile neutropenic cancer patient: ity of the mucosal cells damaged by irradiation, and (iii) the clinical efficacy and...mon- sidered to be inexorable signs of aging and may keb (1,9,28) and babuons (29). Simildrly, the rod- predispose to cancer of the stomach. Early in

Project SQUID. Quarterly Progress Report

DTIC Science & Technology

1948-04-01

connection with temperature measurements we are investigating the infrared emission of the pulse jet. We have a lead sulphide cell which, when...formed on an 11% chrome-iron alloy when oxidized in oxygen at a pressure of one millimeter of mercury (sumnarized in the Annual Report, 1947) show...work has been obtained recently. 36 TABLE I Surface Structures Formed on a 27% Chrome-Iron Oxidized in Dry Oxygen at One Millimeter Mercury

Efficacy of vaccination and nisin Z treatments to eliminate intramammary Staphylococcus aureus infection in lactating cows*

PubMed Central

Guan, Ran; Wu, Jun-qiang; Xu, Wei; Su, Xiao-yan; Hu, Song-hua

2017-01-01

This study evaluated the effect of a Staphylococcus aureus bacterin and nisin on bovine subclinical mastitis. A total of 75 Holstein subclinically mastitic cows were randomly allocated to three groups with 25 cows per group. In group I, an intramammary infusion of nisin Z at a dose of 2.50×106 IU was carried out once daily for three days, and an autogenous S. aureus bacterin was inoculated into the supramammary lymph node one week before and one week after nisin treatment. In group II, nisin was administered in the same way as in group I, but no bacterin was inoculated. Group III received no treatment and served as a control. Milk was aseptically sampled from the affected quarters before and 2, 4, and 6 weeks after treatment, for bacteriological examination and analyses of N-acetyl-β-D-glucosaminidase (NAGase) activity, somatic cell count (SCC), and milk protein and fat contents. Results indicated that, compared to the nisin-treated group, nisin-bacterin treatment significantly reduced intramammary S. aureus infections, reduced the number of quarters with milk SCCs of more than 5×105 cells/ml, and increased the protein and fat contents of the milk. Therefore, nisin-bacterin therapy is suggested when subclinical mastitis occurs in lactating cows. PMID:28378574

On-line milk spectrometry: analysis of bovine milk composition

NASA Astrophysics Data System (ADS)

Spitzer, Kyle; Kuennemeyer, Rainer; Woolford, Murray; Claycomb, Rod

2005-04-01

We present partial least squares (PLS) regressions to predict the composition of raw, unhomogenised milk using visible to near infrared spectroscopy. A total of 370 milk samples from individual quarters were collected and analysed on-line by two low cost spectrometers in the wavelength ranges 380-1100 nm and 900-1700 nm. Samples were collected from 22 Friesian, 17 Jersey, 2 Ayrshire and 3 Friesian-Jersey crossbred cows over a period of 7 consecutive days. Transmission spectra were recorded in an inline flowcell through a 0.5 mm thick milk sample. PLS models, where wavelength selection was performed using iterative PLS, were developed for fat, protein, lactose, and somatic cell content. The root mean square error of prediction (and correlation coefficient) for the nir and visible spectrometers respectively were 0.70%(0.93) and 0.91%(0.91) for fat, 0.65%(0.5) and 0.47%(0.79) for protein, 0.36%(0.49) and 0.45%(0.43) for lactose, and 0.50(0.54) and 0.48(0.51) for log10 somatic cells.

Design and implementation of an inpatient disease management program.

PubMed

Cooper, G S; Armitage, K B; Ashar, B; Costantini, O; Creighton, F A; Raiz, P; Wong, R C; Carlson, M D

2000-07-01

To describe the development and implementation of an inpatient disease management program. Prospective observational study. On the basis of opportunities for improving quality or efficiency of inpatient and emergency department care, 4 diagnoses, including congestive heart failure (CHF), gastrointestinal hemorrhage, community-acquired pneumonia and sickle-cell crisis were selected for implementation of a disease management program. For each diagnosis, a task force assembled a disease management team led by a "physician champion" and nurse care manager and identified opportunities for improvement through medical literature review and interviews with caregivers. A limited number of disease-specific guidelines and corresponding interventions were selected with consensus of the team and disseminated to caregivers. Physician and nurse team leaders were actively involved in patient care to facilitate adherence to guidelines. For quarter 2 to 4 of 1997, there were improvements in angiotensin-converting enzyme inhibitor use, daily weight compliance, assessment of left ventricular function, hospital costs, and length of stay for care-managed patients with CHF. Differences in utilization-related outcomes persisted even after adjustment for severity of illness. For the other 3 diagnoses, the observational period was shorter (quarter 4 only), and hence preliminary data showed similar hospital costs and length of stay for care-managed and noncare-managed patients. An interdisciplinary approach to inpatient disease management resulted in substantial improvements in both quality and efficiency of care for patients with CHF. Additional data are needed to determine the program's impact on outcomes of other targeted diagnoses.

Advances in molecular biology of lung disease: aiming for precision therapy in non-small cell lung cancer.

PubMed

Rooney, Claire; Sethi, Tariq

2015-10-01

Lung cancer is the principal cause of cancer-related mortality in the developed world, accounting for almost one-quarter of all cancer deaths. Traditional treatment algorithms have largely relied on histologic subtype and have comprised pragmatic chemotherapy regimens with limited efficacy. However, because our understanding of the molecular basis of disease in non-small cell lung cancer (NSCLC) has improved exponentially, it has become apparent that NSCLC can be radically subdivided, or molecularly characterized, based on recurrent driver mutations occurring in specific oncogenes. We know that the presence of such mutations leads to constitutive activation of aberrant signaling proteins that initiate, progress, and sustain tumorigenesis. This persistence of the malignant phenotype is referred to as "oncogene addiction." On this basis, a paradigm shift in treatment approach has occurred. Rational, targeted therapies have been developed, the first being tyrosine kinase inhibitors (TKIs), which entered the clinical arena > 10 years ago. These were tremendously successful, significantly affecting the natural history of NSCLC and improving patient outcomes. However, the benefits of these drugs are somewhat limited by the emergence of adaptive resistance mechanisms, and efforts to tackle this phenomenon are ongoing. A better understanding of all types of oncogene-driven NSCLC and the occurrence of TKI resistance will help us to further develop second- and third-generation small molecule inhibitors and will expand our range of precision therapies for this disease.

Corrective Action Management Unit Report of Post-Closure Care Activities Calendar Year 2017.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, Robert; Little, Bonnie Colleen

The Corrective Action Management Unit (CAMU) at Sandia National Laboratories, New Mexico (SNL/NM) consists of a containment cell and ancillary systems that underwent regulatory closure in 2003 in accordance with the Closure Plan in Appendix D of the Class 3 Permit Modification (SNL/NM September 1997). The containment cell was closed with wastes in place. On January 27, 2015, the New Mexico Environment Department (NMED) issued the Hazardous Waste Facility Operating Permit (Permit) for Sandia National Laboratories (NMED January 2015). The Permit became effective February 26, 2015. The CAMU is undergoing post-closure care in accordance with the Permit, as revised andmore » updated. This CAMU Report of Post-Closure Care Activities documents all activities and results for Calendar Year (CY) 2017 as required by the Permit. The CAMU containment cell consists of engineered barriers including a cover system, a bottom liner with a leachate collection and removal system (LCRS), and a vadose zone monitoring system (VZMS). The VZMS provides information on soil conditions under the cell for early leak detection. The VZMS consists of three monitoring subsystems, which include the primary subliner (PSL), a vertical sensor array (VSA), and the Chemical Waste Landfill (CWL) sanitary sewer (CSS) line. The PSL, VSA, and CSS monitoring subsystems are monitored quarterly for soil moisture concentration, the VSA is monitored quarterly for soil temperature, and the VSA and CSS monitoring subsystems are monitored annually for volatile organic compound (VOC) concentrations in the soil vapor at various depths. Baseline data for the soil moisture, soil temperature, and soil vapor were established between October 2003 and September 2004.« less

Environmental Restoration Operations: Consolidated Quarterly Report January -March 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the January, February, and March 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwatermore » [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III. This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent.« less

International petroleum statistics report, February 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-02-01

The International petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual datamore » for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970--1997; OECD stocks from 1973--1997; and OECD trade from 1987--1997.« less

Temporally-stable active precision mount for large optics.

PubMed

Reinlein, Claudia; Damm, Christoph; Lange, Nicolas; Kamm, Andreas; Mohaupt, Matthias; Brady, Aoife; Goy, Matthias; Leonhard, Nina; Eberhardt, Ramona; Zeitner, Uwe; Tünnermann, Andreas

2016-06-13

We present a temporally-stable active mount to compensate for manufacturing-induced deformations of reflective optical components. In this paper, we introduce the design of the active mount, and its evaluation results for two sample mirrors: a quarter mirror of 115 × 105 × 9 mm³, and a full mirror of 228 × 210 × 9 mm³. The quarter mirror with 20 actuators shows a best wavefront error rms of 10 nm. Its installation position depending deformations are addressed by long-time measurements over 14 weeks indicating no significance of the orientation. Size-induced differences of the mount are studied by a full mirror with 80 manual actuators arranged in the same actuator pattern as the quarter mirror. This sample shows a wavefront error rms of (27±2) nm over a measurement period of 46 days. We conclude that the developed mount is suitable to compensate for manufacturing-induced deformations of large reflective optics, and likely to be included in the overall systems alignment procedure.

International petroleum statistics report, May 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-30

The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annualmore » data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1983 through 1993.« less

International petroleum statistics report, August 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-08-26

The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annualmore » data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1993; OECD stocks from 1973 through 1993; and OECD trade from 1983 through 1993.« less

International petroleum statistics report, November 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-11-01

This report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recentmore » year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995. 4 figs., 45 tabs.« less

International petroleum statistics report, February 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-28

The International Petroleum Statistics Report presents data on international oil production, demand, imports, exports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annualmore » data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.« less

FETC/EPRI Biomass Cofiring Cooperative Agreement. Quarterly technical report, April 1-June 30, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, E.; Tillman, D.

1997-12-01

The FETC/EPRI Biomass Cofiring Program has accelerated the pace of cofiring development by increasing the testing activities plus the support activities for interpreting test results. Past tests conducted and analyzed include the Allen Fossil Plant and Seward Generating Station programs. On-going tests include the Colbert Fossil Plant precommercial test program, the Greenidge Station commercialization program, and the Blount St. Station switchgrass program. Tests in the formative stages included the NIPSCO cofiring test at Michigan City Generating Station. Analytical activities included modeling and related support functions required to analyze the cofiring test results, and to place those results into context. Amongmore » these activities is the fuel availability study in the Pittsburgh, PA area. This study, conducted for Duquesne Light, supports their initial investigation into reburn technology using wood waste as a fuel. This Quarterly Report, covering the third quarter of the FETC/EPRI Biomass Cofiring Program, highlights the progress made on the 16 projects funded under this cooperative agreement.« less

78 FR 11140 - BE-605: Quarterly Survey of Foreign Direct Investment in the United States-Transactions of U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... BE-605: Quarterly Survey of Foreign Direct Investment in the United States--Transactions of U.S... conducting the mandatory survey titled BE-605, Quarterly Survey of Foreign Direct Investment in the United... quarterly Form BE-605 is required from each U.S. business enterprise in which a foreign entity has a direct...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2013 CFR

2013-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2011 CFR

2011-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2012 CFR

2012-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2014 CFR

2014-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2010 CFR

2010-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

Code of Federal Regulations, 2012 CFR

2012-04-01

... & poor's 500 stock composite index for calendar 1971] Quarterly ending— Index value 1 Quarterly dividend yield-composite index Annual percent 2 Quarterly percent 3 (1/4 of annual) Dec. 1970 92.15 Mar. 1971 100... Investment record of Standard & Poor's 500 stock composite index assuming quarterly reinvestment dividends...

17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

Code of Federal Regulations, 2013 CFR

2013-04-01

... & poor's 500 stock composite index for calendar 1971] Quarterly ending— Index value 1 Quarterly dividend yield-composite index Annual percent 2 Quarterly percent 3 (1/4 of annual) Dec. 1970 92.15 Mar. 1971 100... Investment record of Standard & Poor's 500 stock composite index assuming quarterly reinvestment dividends...

17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

Code of Federal Regulations, 2011 CFR

2011-04-01

... & poor's 500 stock composite index for calendar 1971] Quarterly ending— Index value 1 Quarterly dividend yield-composite index Annual percent 2 Quarterly percent 3 (1/4 of annual) Dec. 1970 92.15 Mar. 1971 100... Investment record of Standard & Poor's 500 stock composite index assuming quarterly reinvestment dividends...

17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

Code of Federal Regulations, 2010 CFR

2010-04-01

... & poor's 500 stock composite index for calendar 1971] Quarterly ending— Index value 1 Quarterly dividend yield-composite index Annual percent 2 Quarterly percent 3 (1/4 of annual) Dec. 1970 92.15 Mar. 1971 100... Investment record of Standard & Poor's 500 stock composite index assuming quarterly reinvestment dividends...

Viability of bovine demi- and quarter-embryos after transfer.

PubMed

Bredbacka, P; Huhtinen, M; Aalto, J; Rainio, V

1992-07-01

The viability of bovine demi- and quarter-embryos was investigated. Early compacting morulae were nonsurgically flushed from superovulated donor cows and were bisected by two microneedles. One of the halves was then split further into two quarters. Each demi- and quarter-embryo was placed in an evacuated zona pellucida. One demi- or two quarter-embryos were transferred non-surgically into cow or heifer recipients. Viability was measured by ultrasound scanning of the fetuses on Days 35, 48 and 60 of pregnancy. The pregnancy rates at Day 60 were 46.2% (6/13) for heifers and 33.3% (4/12) for cows after the transfer of a single demi-embryo. The transfer of two quarter-embryos resulted in a pregnancy rate of 61.5% (8/13) for heifers and 8.3% (1/12) for cows. Seven (53.8%) and four (33.3%) live fetuses were found on Day 60 following the transfer of demi-embryos into heifers and cows, respectively. The transfer of quarter-embryos resulted in 10 fetuses (38.5%) in the heifer recipients and only one fetus (4.2%) in the cow recipients. The results of this study suggest that heifers are more suitable than cows as recipients for quarter-embryos.

Sustained meticillin-resistant Staphylococcus aureus control in a hyper-endemic tertiary acute care hospital with infrastructure challenges in Singapore.

PubMed

Fisher, D; Tambyah, P A; Lin, R T P; Jureen, R; Cook, A R; Lim, A; Ong, B; Balm, M; Ng, T M; Hsu, L Y

2013-10-01

Meticillin-resistant Staphylococcus aureus (MRSA) has been entrenched in Singapore hospitals since the 1980s, with an excess of 600 non-duplicate cases of infections (120 bacteraemia episodes) each year in our 995-bed university hospital. Approximately 5% of our hospital beds are used as isolation facilities. To study the impact of an MRSA control bundle that was implemented via gradual geographic extension across hospital wards. The bundle included active surveillance on admission and transfer/discharge to identify ward-based acquisition of MRSA, isolation and cohorting of MRSA-infected patients, enhanced hand hygiene initiatives, and publicly displayed feedback of MRSA acquisition and hand hygiene compliance rates. Implementation was between October 2006 and June 2010 in order to provide lead-time for the incremental development of infrastructural capacity, and to develop an ethic of infection prevention among staff. Results were analysed via interrupted time-series analysis. MRSA infections fell midway through the implementation, with MRSA bacteraemia declining from 0.26 [95% confidence interval (CI): 0.18-0.34] cases per 1000 inpatient-days in the first quarter of 2004 to 0.11 (95% CI: 0.07-0.19) cases per 1000 inpatient-days in the first quarter of 2012. MRSA acquisition rates fell a year after the programme had been fully implemented, whereas hand hygiene compliance rose significantly from 47% (95% CI: 44-49) in the first quarter of 2009 to 69% (95% CI: 68-71) in the first quarter of 2012. Successful staged implementation of an MRSA bundle in a hyper-endemic setting is sustainable and represents a model that may be adapted for similar settings. Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Developing a Taxonomy of Institutional Sponsored Work Experience.

ERIC Educational Resources Information Center

Heinemann, Harry N.; Wilson, James W.

1995-01-01

The name of the work-integrated education program, its learning objectives, and other program characteristics were gathered from 18 colleges/universities and 2 community colleges. Three-quarters use internship, practicum, or co-op. Factor analysis grouped objectives as cognitive, communication, job seeking, personal development, career…

Curriculum.

ERIC Educational Resources Information Center

Hiatt, Evelyn Levsky, Ed.; Covington, Jeanette, Ed.

1991-01-01

This document is a "theme" issue of a quarterly serial publication. It focuses on curriculum development for gifted students. A list of 13 principles of a differentiated curriculum for gifted/talented students precedes the articles. The first article, "Developing Curriculum for Gifted/Talented" by Jim Coffey, offers a philosophical rationale for a…

Is Piaget Wrong?

ERIC Educational Resources Information Center

Crossland, John

2015-01-01

Piaget's theories of the structure of knowledge, constructivist learning, and stages of development in thinking have been a cornerstone of cognitive psychology and teacher education for half a century (Piaget, 1983). More recently, his ideas about stages of cognitive development have received criticism from many quarters (Weiten, 1992), including…

Deployment Ready Airway Management System (DRAMS)

DTIC Science & Technology

2013-10-24

have been developed along with rapid prototypes. The results have been excellent and DMLS Alpha one and two prototypes have been developed resulting...Contact Model Quarterly  Report               10/25/2013 DMLS FlexBlade Reusable Module B-1 Prototype

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-13

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Shafer, Jaclyn; Huddleston, Lisa

2013-01-01

Ms. Shafer completed the task to determine relationships between pressure gradients and peak winds at Vandenberg Air Force Base (VAFB), and began developing a climatology for the VAFB wind towers; Dr. Huddleston completed the task to develop a tool to help forecast the time of the first lightning strike of the day in the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) area; Dr. Bauman completed work on a severe weather forecast tool focused on the Eastern Range (ER), and also developed upper-winds analysis tools for VAFB and Wallops Fl ight Facility (WFF); Ms. Crawford processed and displayed radar data in the software she will use to create a dual-Doppler analysis over the east-central Florida and KSC/CCAFS areas; Mr. Decker completed developing a wind pairs database for the Launch Services Program to use when evaluating upper-level winds for launch vehicles; Dr. Watson continued work to assimilate observational data into the high-resolution model configurations she created for WFF and the ER.

Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Technical progress report number 11, January 1--March 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-06-11

During this quarter, the third draft of the Topical Report on Process Economics Studies was issued for review. A recommendation to continue with design verification testing on the coproduction of methanol and dimethyl ether (DME) was made. A liquid phase dimethyl ether (LPDME) catalyst system with reasonable long-term activity and stability is being developed, and a decision to proceed with a proof-of-concept test run at the LaPorte Alternative Fuels Development Unit (AFDU) is pending the release of a memo from Air Products on the catalyst targets and corresponding economics for a commercially successful LPDME catalyst. The off-site product-use test planmore » is to be updated in June of 1997. During this quarter, Air Products and Acurex Environmental Corporation continued developing the listing of product-use test participants who are involved in fuel cell, transportation, and stationary power plant applications. Start-up activities (Task 3.1) began during the reporting period, and coal-derived synthesis gas (syngas) was introduced to the demonstration unit. The recycle compressor was tested successfully on syngas at line pressure of 700 psig, and the reactor loop reached 220 C for carbonyl burnout. Iron carbonyl in the balanced gas feed remained below the 10 ppbv detection limit for all samples but one. Within the reactor loop, iron carbonyl levels peaked out near 200 ppbv after about 40 hours on-stream, before decreasing to between 10--20 ppbv at 160 hours on -stream. Nickel carbonyl measurements reached a peak of about 60 ppbv, and decreased at all sampling locations to below the 10 ppbv detection limit by 70 hours on-stream. Catalyst activation of the nine 2,250 lb batches required for the initial catalyst charge began and concluded. All batches met or slightly exceeded the theoretical maximum uptake of 2.82 SCF of reducing gas/lb catalyst.« less

Idaho National Laboratory Quarterly Occurrence Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth Ann

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 85 reportable events (18 from the 4th Qtr FY-15 and 67 from the prior three reporting quarters), as well as 25 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (8 from this quarter and 17 from the prior three quarters).« less

Educating the Human Brain. Human Brain Development Series

ERIC Educational Resources Information Center

Posner, Michael I.; Rothbart, Mary K.

2006-01-01

"Educating the Human Brain" is the product of a quarter century of research. This book provides an empirical account of the early development of attention and self regulation in infants and young children. It examines the brain areas involved in regulatory networks, their connectivity, and how their development is influenced by genes and…

ARPA-E Program: Advanced Management Protection of Energy Storage Devices (AMPED) - Fifth Quarterly Project Report - FY14 Q1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, Joseph

Technology has been developed that enables monitoring of individual cells in high - capacity lithium-ion battery packs, with a distributed array of wireless Bluetooth 4.0 tags and sensors, and without proliferation of extensive wiring harnesses. Given the safety challenges facing lithium-ion batteries in electric vehicle, civilian aviation and defense applications, these wireless sensors may be particularly important to these emerging markets. These wireless sensors will enhance the performance, reliability and safety of such energy storage systems. Specific accomplishments to date include, but are not limited to: (1) the development of wireless tags using Bluetooth 4.0 standard to monitor a largemore » array of sensors in battery pack; (2) sensor suites enabling the simultaneous monitoring of cell voltage, cell current, cell temperature, and package strain, indicative of swelling and increased internal pressure, (3) small receivers compatible with USB ports on portable computers; (4) software drivers and logging software; (5) a 7S2P battery simulator, enabling the safe development of wireless BMS hardware in the laboratory; (6) demonstrated data transmission out of metal enclosures, including battery box, with small variable aperture opening; (7) test data demonstrating the accurate and reliable operation of sensors, with transmission of terminal voltage, cell temperature and package strain at distances up to 110 feet; (8) quantification of the data transmission error as a function of distance, in both indoor and outdoor operation; (9) electromagnetic interference testing during operation with live, high -capacity battery management system at Yardney Technical Products; (10) demonstrat ed operation with live high-capacity lithium-ion battery pack during charge-discharge cycling; (11) development of special polymer-gel lithium-ion batteries with embedded temperature sensors, capable of measuring the core temperature of individual of the cells during charge-discharge cycling at various temperatures, thereby enabling earlier warning of thermal runaway than possible with external sensors. Ultimately, the team plans to extend this work to include: (12) flexible wireless controllers, also using Bluetooth 4.0 standard, essential for balancing large-scale battery packs. LLNL received $925K for this project, and has $191K remaining after accomplishing these objectives.« less

Photographic copy of floor plans for Bachelor Officers' Quarters (Tl) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of floor plans for Bachelor Officers' Quarters (T-l) known as the "Desert Rat Hotel" in the early days of the Muroc Flight Test Base (North Base). The plans show the layout of quarters, lavatories, mess as well as, the cooling system installation. Contract W-509-Eng 2937, Military Construction; Muroc Bombing Range, Muroc Lake, Calif; Materiel Test Site, Officers Quarters, Evaporative Coolers, Sheet 5 of 11, May 1942. Reproduced from the holdings of the National Archives, Pacific Southwest Region - Edwards Air Force Base, North Base, Bachelor Officers' Quarters T-1, Second & C Streets, Boron, Kern County, CA

General view of Quarters (Building No. 44) and Lake Jeanette ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of Quarters (Building No. 44) and Lake Jeanette looking southeast. - National Home for Disabled Volunteer Soldiers, Western Branch, Quarters, Franklin Avenue, Leavenworth, Leavenworth County, KS

Usage Statistics

MedlinePlus

... this page: https://medlineplus.gov/usestatistics.html MedlinePlus Statistics To use the sharing features on this page, ... By Quarter View image full size Quarterly User Statistics Quarter Page Views Unique Visitors Oct-Dec-98 ...

Molecular epidemiology and strain-specific characteristics of Streptococcus agalactiae at the herd and cow level.

PubMed

Mahmmod, Y S; Klaas, I C; Katholm, J; Lutton, M; Zadoks, R N

2015-10-01

Host-adaptation of Streptococcus agalactiae subpopulations has been described whereby strains that are commonly associated with asymptomatic carriage or disease in people differ phenotypically and genotypically from those causing mastitis in dairy cattle. Based on multilocus sequence typing (MLST), the most common strains in dairy herds in Denmark belong to sequence types (ST) that are also frequently found in people. The aim of this study was to describe epidemiological and diagnostic characteristics of such strains in relation to bovine mastitis. Among 1,199 cattle from 6 herds, cow-level prevalence of S. agalactiae was estimated to be 27.4% based on PCR and 7.8% based on bacteriological culture. Quarter-level prevalence was estimated at 2.8% based on bacteriological culture. Per herd, between 2 and 26 isolates were characterized by pulsed-field gel electrophoresis (PFGE) and MLST. Within each herd, a single PFGE type and ST predominated, consistent with a contagious mode of transmission or point source infection within herds. Evidence of within-herd evolution of S. agalactiae was detected with both typing methods, although ST belonged to a single clonal complex (CC) per herd. Detection of CC23 (3 herds) was associated with significantly lower approximate count (colony-forming units) at the quarter level and significantly lower cycle threshold value at the cow level than detection of CC1 (2 herds) or CC19 (1 herd), indicating a lower bacterial load in CC23 infections. Median values for the number of infected quarters and somatic cell count (SCC) were numerically but not significantly lower for cows infected with CC23 than for cows with CC1 or CC19. For all CC, an SCC threshold of 200,000 cells/mL was an unreliable indicator of infection status, and prescreening of animals based on SCC as part of S. agalactiae detection and eradication campaigns should be discouraged. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Quarterly Research Performance Progress Report (2015 Q3). Ultrasonic Phased Arrays and Interactive Reflectivity Tomography for Nondestructive Inspection of Injection and Production Wells in Geothermal Energy Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santos-Villalobos, Hector J; Polsky, Yarom; Kisner, Roger A

2015-09-01

For the past quarter, we have placed our effort in implementing the first version of the ModelBased Iterative Reconstruction (MBIR) algorithm, assembling and testing the electronics, designing transducers mounts, and defining our laboratory test samples. We have successfully developed the first implementation of MBIR for ultrasound imaging. The current algorithm was tested with synthetic data and we are currently making new modifications for the reconstruction of real ultrasound data. Beside assembling and testing the electronics, we developed a LabView graphic user interface (GUI) to fully control the ultrasonic phased array, adjust the time-delays of the transducers, and store the measuredmore » reflections. As part of preparing for a laboratory-scale demonstration, the design and fabrication of the laboratory samples has begun. Three cement blocks with embedded objects will be fabricated, characterized, and used to demonstrate the capabilities of the system. During the next quarter, we will continue to improve the current MBIR forward model and integrate the reconstruction code with the LabView GUI. In addition, we will define focal laws for the ultrasonic phased array and perform the laboratory demonstration. We expect to perform laboratory demonstration by the end of October 2015.« less

Mass-spring matching layers for high-frequency ultrasound transducers: a new technique using vacuum deposition.

PubMed

Brown, Jeremy; Sharma, Srikanta; Leadbetter, Jeff; Cochran, Sandy; Adamson, Rob

2014-11-01

We have developed a technique of applying multiple matching layers to high-frequency (>30 MHz) imaging transducers, by using carefully controlled vacuum deposition alone. This technique uses a thin mass-spring matching layer approach that was previously described in a low-frequency (1 to 10 MHz) transducer design with epoxied layers. This mass- spring approach is more suitable to vacuum deposition in highfrequency transducers over the conventional quarter-wavelength resonant cavity approach, because thinner layers and more versatile material selection can be used, the difficulty in precisely lapping quarter-wavelength matching layers is avoided, the layers are less attenuating, and the layers can be applied to a curved surface. Two different 3-mm-diameter 45-MHz planar lithium niobate transducers and one geometrically curved 3-mm lithium niobate transducer were designed and fabricated using this matching layer approach with copper as the mass layer and parylene as the spring layer. The first planar lithium niobate transducer used a single mass-spring matching network, and the second planar lithium niobate transducer used a single mass-spring network to approximate the first layer in a dual quarter-wavelength matching layer system in addition to a conventional quarter-wavelength layer as the second matching layer. The curved lithium niobate transducer was press focused and used a similar mass-spring plus quarter-wavelength matching layer network. These transducers were then compared with identical transducers with no matching layers and the performance improvement was quantified. The bandwidth of the lithium niobate transducer with the single mass-spring layer was measured to be 46% and the insertion loss was measured to be -21.9 dB. The bandwidth and insertion loss of the lithium niobate transducer with the mass-spring network plus quarter-wavelength matching were measured to be 59% and -18.2 dB, respectively. These values were compared with the unmatched transducer, which had a bandwidth of 28% and insertion loss of -34.1 dB. The bandwidth and insertion loss of the curved lithium niobate transducer with the mass-spring plus quarter-wavelength matching layer combination were measured to be 68% and -26 dB, respectively; this compared with the measured unmatched bandwidth and insertion loss of 35% and -37 dB. All experimentally measured values were in excellent agreement with theoretical Krimholtz-Leedom-Matthaei (KLM) model predictions.

14. INTERIOR OF TYPICAL SLEEPING QUARTERS, BUILDING 208, LOOKING SOUTHEAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. INTERIOR OF TYPICAL SLEEPING QUARTERS, BUILDING 208, LOOKING SOUTHEAST. - Mill Valley Air Force Station, Bachelor Airmen Quarters, East Ridgecrest Boulevard, Mount Tamalpais, Mill Valley, Marin County, CA

Electric power quarterly, January-March 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1984-07-01

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. These data are published to provide meaningful, timely, objective, and accurate energy information for a wide audience including Congress, Federal and State agencies, industry, and the general public.

20 CFR 404.133 - When we give you quarters of coverage based on military service to establish a period of disability.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false When we give you quarters of coverage based on military service to establish a period of disability. 404.133 Section 404.133 Employees' Benefits... Status and Quarters of Coverage Disability Insured Status § 404.133 When we give you quarters of coverage...

20 CFR 404.133 - When we give you quarters of coverage based on military service to establish a period of disability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false When we give you quarters of coverage based on military service to establish a period of disability. 404.133 Section 404.133 Employees' Benefits... Status and Quarters of Coverage Disability Insured Status § 404.133 When we give you quarters of coverage...

20 CFR 404.133 - When we give you quarters of coverage based on military service to establish a period of disability.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false When we give you quarters of coverage based on military service to establish a period of disability. 404.133 Section 404.133 Employees' Benefits... Status and Quarters of Coverage Disability Insured Status § 404.133 When we give you quarters of coverage...

20 CFR 404.133 - When we give you quarters of coverage based on military service to establish a period of disability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false When we give you quarters of coverage based on military service to establish a period of disability. 404.133 Section 404.133 Employees' Benefits... Status and Quarters of Coverage Disability Insured Status § 404.133 When we give you quarters of coverage...

27 CFR 53.157 - Deposit requirement for deposits made for calendar quarters prior to July 1, 1995.

Code of Federal Regulations, 2010 CFR

2010-04-01

... calendar quarter, the person deposits any underpayment for the month by the 9th day of the second month... quarter, the person deposits any underpayment for such month by the 9th day of the second month following... month in a calendar quarter, the person deposits any underpayment for such month by the 9th day of the...

Biopsychosocial characteristics of community-dwelling older adults with limited ability to walk one-quarter of a mile.

PubMed

Hardy, Susan E; McGurl, David J; Studenski, Stephanie A; Degenholtz, Howard B

2010-03-01

To establish nationally representative estimates of the prevalence of self-reported difficulty and inability of older adults to walk one-quarter of a mile and to identify the characteristics independently associated with difficulty or inability to walk one-quarter of a mile. Cross-sectional analysis of data from the 2003 Cost and Use Medicare Current Beneficiary Survey. Community. Nine thousand five hundred sixty-three community-dwelling Medicare beneficiaries aged 65 and older, representing an estimated total population of 34.2 million older adults. Self-reported ability to walk one-quarter of a mile, sociodemographics, chronic conditions, body mass index, smoking, functional status. In 2003, an estimated 9.5 million older Medicare beneficiaries had difficulty walking one-quarter of a mile, and 5.9 million were unable to do so. Of the 20.2 million older adults with no difficulty in activities of daily living (ADLs) or instrumental activities of daily living (IADLs), an estimated 4.3 million (21%) had limited ability to walk one-quarter of a mile. Having difficulty or being unable to walk one-quarter of a mile was independently associated with older age, female sex, non-Hispanic ethnicity, lower educational level, Medicaid entitlement, most chronic medical conditions, current smoking, and being overweight or obese. Almost half of older adults and 20% of those reporting no ADL or IADL limitations report limited ability to walk one-quarter of a mile. For functionally independent older adults, reported ability to walk one-quarter of a mile can identify vulnerable older adults with greater medical problems and fewer resources and may be a valuable clinical marker in planning their care. Future work is needed to determine the association between ability to walk one-quarter of a mile walk and subsequent functional decline and healthcare use.

Research on Children's Play: Analysis of Developmental and Early Education Journals from 2005 to 2007

ERIC Educational Resources Information Center

Cheng, Mei-Fang; Johnson, James E.

2010-01-01

Our review examined four early childhood journals ("Early Child Development and Care," "Early Childhood Education Journal," "Journal of Research in Childhood Education," and "Early Childhood Research Quarterly") and four developmental science journals ("Child Development," "Developmental Psychology," "Journal of Applied Developmental…

2. EAST SIDE OF SLAVE QUARTERS (Jack E. Boucher, photgrapher, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. EAST SIDE OF SLAVE QUARTERS (Jack E. Boucher, photgrapher, April/May, 1986) - Felix & Odile Pratt Valle Slave Quarters, Southeast corner of Merchant & Second Streets, Sainte Genevieve, Ste. Genevieve County, MO

WARRANT OFFICER AND CIVILIAN HOUSING, QUARTERS L FRONT ELEVATION. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

WARRANT OFFICER AND CIVILIAN HOUSING, QUARTERS L FRONT ELEVATION. - Naval Magazine Lualualei, Headquarters Branch, Warrant Officer's & Civilians Quarters Type, Along Sixty-sixth Street between Amberjack & Constitution Streets, Pearl City, Honolulu County, HI

Creating objective and measurable postgraduate year 1 residency graduation requirements.

PubMed

Starosta, Kaitlin; Davis, Susan L; Kenney, Rachel M; Peters, Michael; To, Long; Kalus, James S

2017-03-15

The process of developing objective and measurable postgraduate year 1 (PGY1) residency graduation requirements and a progress tracking system is described. The PGY1 residency accreditation standard requires that programs establish criteria that must be met by residents for successful completion of the program (i.e., graduation requirements), which should presumably be aligned with helping residents to achieve the purpose of residency training. In addition, programs must track a resident's progress toward fulfillment of residency goals and objectives. Defining graduation requirements and establishing the process for tracking residents' progress are left up to the discretion of the residency program. To help standardize resident performance assessments, leaders of an academic medical center-based PGY1 residency program developed graduation requirement criteria that are objective, measurable, and linked back to residency goals and objectives. A system for tracking resident progress relative to quarterly progress targets was instituted. Leaders also developed a focused, on-the-spot skills assessment termed "the Thunderdome," which was designed for objective evaluation of direct patient care skills. Quarterly data on residents' progress are used to update and customize each resident's training plan. Implementation of this system allowed seamless linkage of the training plan, the progress tracking system, and the specified graduation requirement criteria. PGY1 residency requirements that are objective, that are measurable, and that attempt to identify what skills the resident must demonstrate in order to graduate from the program were developed for use in our residency program. A system for tracking the residents' progress by comparing residents' performance to predetermined quarterly benchmarks was developed. Copyright © 2017 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

The AMTEX Partnership. Third quarterly report, FY 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemon, D.K.; Quisenberry, R.K.

1995-06-01

Key activities for the quarter were the initiation of tactical work on the OPCon Project, development of a draft of the AMTEX Policies and Procedures document, and a meeting of the Industry Technical Advisory Committee. A significant milestone was reached when a memorandum of understanding was signed between the DOE and The Department of Commerce. The agreement signified the official participation of the National Institute of Standards and Technology on the Demand Activated Manufacturing Architecture (DAMA) project in AMTEX. Project accomplishments are given for: computer-aided manufacturing, cotton biotechnology, DAMA, electronic embedded fingerprints, rapid cutting, sensors for agile manufacturing, and textilemore » resource conservation.« less

AFRRI Reports, Third-Fourth Quarters

DTIC Science & Technology

1998-02-01

structural changes de- induce CPEs, and CPE was blocked by amantadine. N- scribed here for the effect of IV on J774.1 cells were Acetylcysteine and pyrrolidine...assayed. Inhibitors were N- acetylcysteine (NAC, 50 mM), pyrrolidine block CPEs (data not shown). dithiocarbamate (PDTC, 100 mM), deferoximine nesyiate (DEF...thyroid axis (34-39), partly due to suppression of TRH gene expression in the hypothala- mus (39). This inhibition may account for the depression of

Improving Joint Function Using Photochemical Hydrogels for Articular Surface Repair

DTIC Science & Technology

2012-10-01

with thrombin previously has been reported as a favorable scaffold for cartilage formation by encapsulated chondrocytes [10]. Studies over the past...during the photochemical crosslinking process. A full scale study is planned for the first quarter of year 3 to evaluate the fully formed cartilage ...Perform initial study of collagen and PEG gels with stem cells implanted in mice  Bone marrow MSCs were harvested from donor swine and grown in culture

Investigation of Test Methods, Material Properties, and Processes for Solar Cell Encapsulants

NASA Technical Reports Server (NTRS)

1979-01-01

During this quarter the technical activities were directed toward the reformulation of ethylene/vinyl acetate copolymer for use as a compound in solar cell module fabrication. Successful formulations were devised that lowered the temperature required for cure and raised the gel content. A major volatile component was also eliminated (acrylate crosslinking agent) which should aid in the production of bubble free laminates. Adhesive strengths and primers for the bonding of ethylene/vinyl acetate to supersyrate and substrate materials was assessed with encouraging results. The incorporation of silane compounds gave high bond strengths. A survey of scrim materials was also conducted.

Uncapped mRNA introduced into tobacco protoplasts can be imported into the nucleus and is trapped by leptomycin B.

PubMed

Stuger, Rogier; Forreiter, Christoph

2004-08-01

The mechanism of nuclear export of RNAs in yeast and animal cells is rapidly being uncovered, but RNA export in plants has received little attention. We introduced capped and uncapped fluorescent mRNAs into tobacco (Nicotiana plumbaginifolia) protoplasts and studied their cellular localization. Following insertion, capped transcripts were found in the cytoplasm, while uncapped messengers transiently appeared in the nucleus in about one-quarter to one-third of the cells. These mRNAs were trapped by the nuclear export-inhibiting drug leptomycin B, pointing to an export mechanism in plants similar to Rev-NES-mediated RNP export in other organisms.

Leveraging Leadership for Better Business: A Look at Civil Engineering in the Air Force

DTIC Science & Technology

1999-12-05

What does it all mean ?" CE Quarterly Magazine article dated Winter 98 - "The Air Force Civil Engineer...Future" CE Quarterly Magazine article dated Winter 98 - "Civil Engineering Outsourcing: What does it all mean ?" CE Quarterly Magazine article dated...Engineering Outsourcing: What does it all mean ?" CE Quarterly Magazine article dated Winter 98 - "The Air Force Civil Engineer

Hawaiian Volcano Observatory 1960 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1959 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1971 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1961 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1958 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1962 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1970 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1973 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1966 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1965 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1964 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1957 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1972 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1969 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1967 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1968 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1963 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Academic Leadership Development: A Case Study.

PubMed

Berman, Audrey

2015-01-01

A dean at a private school of nursing implemented a leadership development program for early- to mid-career nursing faculty consisting of one 4-hour evening session per academic quarter for 7 quarters. Eight faculty members who had expressed interest in assuming a leadership role or been recommended by their supervisors as having strong leadership potential were invited to join. Program topics included leadership pathways, legal issues, budgeting and governance, diversity, the political arena, human resources, and student issues. Interviews with participants revealed 6 themes: the support a peer cohort provided, a desire for real-life application, a lack of previous exposure to related content or experiences, new perceptions of themselves as academic nurse leaders, the value of the program as preparation for academic nursing leadership roles, and broad program applicability. Copyright © 2015 Elsevier Inc. All rights reserved.

Darbepoetin alfa therapeutic interchange protocol for anemia in dialysis.

PubMed

Brophy, Donald F; Ripley, Elizabeth Bd; Kockler, Denise R; Lee, Seina; Proeschel, Lori A

2005-11-01

Erythropoiesis-stimulating proteins, such as erythropoietin alfa and darbepoetin alfa, have positively impacted anemia management. These medications improve patient outcomes and quality of life. Their costs, however, remain a major barrier for health systems. To evaluate the development, implementation, and cost-effectiveness of an inpatient therapeutic interchange protocol for erythropoiesis-stimulating proteins at a large, tertiary care, university-affiliated health system. Virginia Commonwealth University Health System (VCUHS) developed and implemented a therapeutic interchange program to convert therapy for all inpatients undergoing dialysis from erythropoietin alfa to darbepoetin alfa for treatment of chronic kidney disease-related anemia. An evaluation of the economic impact of this program on drug expenditures over a fiscal quarter (2003) was conducted using historical comparator data (2002). Preliminary evaluation of the program demonstrated cost-savings and reduced drug utilization of erythropoiesis-stimulating proteins in hospitalized dialysis patients. For the first quarter of 2003 compared with the first quarter of 2002, VCUHS realized a cost-savings of nearly 10,000 US dollars, which was related to the program's aggressive screening procedure. When these data were normalized for equal numbers of patients in each group receiving one of the drugs, the actual cost-savings was over 2000 US dollars. These cost-savings are largely due to reduced utilization of these expensive biotechnology products with implementation of a dosing protocol. VCUHS has successfully developed and implemented a darbepoetin alfa therapeutic interchange protocol for hospitalized dialysis patients. This has translated into reduced use of erythropoiesis-stimulating proteins, resulting in cost-savings for the health system.

ER Consolidated Qtrly Rpt_April thru June 2015_October 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John

2015-10-01

This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit, and the Compliance Order on Consent. The 13 sites in the Corrective Action process are listed in Table I-1. Because the status of any Long-Term Stewardship (LTS) activity is detailed in other reports, Section I.3.0 (titled Long-Term Stewardship Work Completed) will not be presented in future ER Quarterly Reports. Section I.3.0 of this ER Quarterly Report identifies the other reports that detail LTS activities.

[Nomadic plastic surgery: 1 NGO, 10 years, 30 missions].

PubMed

Knipper, P; Antoine, P; Carré, C; Baudet, J

2015-06-01

This publication presents the results of 10 years of nomadic plastic surgery missions by a small French non-governmental organization: Interplast-France/surgery without borders (www.Interplast-France.net). This NGO is specialized in reconstructive surgery in challenging conditions and works in developing countries. We present a view of 10 years of missions carried out between 2003 and 2013. This experience covers a uniform period both by the objectives proposed and the regularity of missions observed. This work shows the way surgical missions take place and the methodology used. We carried out 30 missions. We made more than 4000 consultations and we operated 1500 patients. Interventions are divided into one quarter cleft, one quarter tumors, one quarter burn injuries and one quarter of various diseases such as noma and Buruli ulcer. We show some adaptations such as autonomy during missions, the adjustment guidance in relation to this new environment and the integration of local traditions in our therapeutic action. We offer practical notions on the surgical procedures and some reflections on the societal level. This work aims primarily to pay tribute to all the invisible actors in this long chain of humanity, and thanks to the simple intervention of men, a patient can have the same medical treatment whether he is in an industrial country or in some isolated place on this earth. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Cutaway View of the Skylab Orbital Workshop

NASA Technical Reports Server (NTRS)

1973-01-01

This illustration is a cutaway view of a half of the Skylab Orbital Workshop (OWS) showing details of the living and working quarters. The OWS was divided into two major compartments. The lower level provided crew accommodations for sleeping, food preparation and consumption, hygiene, waste processing and disposal, and performance of certain experiments. The upper level consisted of a large work area and housed water storage tanks, a food freezer, storage vaults for film, scientific airlocks, mobility and stability experiment equipment, and other experimental equipment. The compartment below the crew quarters was a container for liquid and solid waste and trash accumulated throughout the mission. A solar array, consisting of two wings covered on one side with solar cells, was mounted outside the workshop to generate electrical power to augment the power generated by another solar array mounted on the solar observatory. Thrusters were provided at one end of the workshop for short-term control of the attitude of the space station.

Identification of subsurface microorganisms at Yucca Mountain. Quarterly report, July 1, 1995--September 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stetzenbach, L.D.

1995-12-01

More than 1100 bacterial isolates were obtained over a two year period from 31 springs in a region along the southern boarder of California and Nevada. Water samples were collected from 17 springs in Ash Meadows National Wildlife Refuge and 14 springs in Death Valley National Park. Bacteria isolated from these samples were subjected to extraction and gas chromatography to determine the cellular fatty acid profile of each isolate. Fatty acid methyl esters (FAME) extracted from cell membranes were separated and classified using the Hewlett Packard by gas chromatography. The FAME profiles of each isolate were then subjected to clustermore » analysis by the unweighted pair-group method using arithmetic averages. During this quarter the relatedness of FAME patterns of bacterial isolates were examined at the genus level by counting the number of clusters produced in a MIDI dendrogram at a Euclidian distance of 25. This information was then used to determine microbiological relationships among springs.« less

75 FR 22805 - Submission for OMB Review; American Recovery and Reinvestment Act-Quarterly Reporting for Prime...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Recovery and Reinvestment Act--Quarterly Reporting for Prime Contractors AGENCIES: Department of Defense... Reinvestment Act--Quarterly Reporting for Prime Contractors published in the Federal Register is being...

The Journal of Staff, Program, & Organization Development, Volume 14, Numbers 1-4, 1996-97. New Forums Faculty Development Series.

ERIC Educational Resources Information Center

Neal, Edward, Ed.

1997-01-01

This quarterly publication serves as a medium for the exchange of ideas regarding the planning, design, implementation, and evaluation of professional development practices at two- and four-year colleges. The four issues in volume 14 feature the following articles: (1) "A Home-Grown Faculty Development Program," (Jane T. Rauton); (2) "Creating…

Twelve solar-heating/cooling systems: Design and development

NASA Technical Reports Server (NTRS)

1980-01-01

Two quarterly reports describe first 6 months of development on single family, multifamily, and commercial installations in Minneapolis area. Reports discuss basic requirements, and reasons for selecting specific configurations. Systems consist of liquid cooled flat plate collectors, two fluid loops, and gas-fired forced-air auxiliary heat source.

Washback in Language Assessment

ERIC Educational Resources Information Center

Green, Anthony

2013-01-01

This paper reviews the progress made in washback studies over the quarter century since Hughes' (1989) placed it at the centre of his textbook "Testing for Language Teachers." Research into washback and the development of models of washback are described and an agenda is suggested for test developers wishing to build washback into…

76 FR 59719 - Notice of Regulatory Waiver Requests Granted for the Second Quarter of Calendar Year 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5529-N-02] Notice of Regulatory Waiver.... ACTION: Notice. SUMMARY: Section 106 of the Department of Housing and Urban Development Reform Act of..., Department of Housing and Urban Development, 451 7th Street, SW., Room 10282, Washington, DC 20410- 0500...

Development and Demonstration of a Statistical Data Base System for Library and Network Planning and Evaluation. Fourth Quarterly Report.

ERIC Educational Resources Information Center

Jones, Dennis; And Others

The National Center for Higher Education Management Systems (NCHEMS) has completed the development and demonstration of a library statistical data base. The data base, or management information system, was developed for administrators of public and academic libraries. The system provides administrators with a framework of information and…

Evaluation of the udder health status in subclinical mastitis affected dairy cows through bacteriological culture, somatic cell count and thermographic imaging.

PubMed

Bortolami, A; Fiore, E; Gianesella, M; Corrò, M; Catania, S; Morgante, M

2015-01-01

Subclinical mastitis in dairy cows is a big economic loss for farmers. The monitoring of subclinical mastitis is usually performed through Somatic Cell Count (SCC) in farm but there is the need of new diagnostic systems able to quickly identify cows affected by subclinical infections of the udder. The aim of this study was to evaluate the potential application of thermographic imaging compared to SCC and bacteriological culture for infection detection in cow affected by subclinical mastitis and possibly to discriminate between different pathogens. In this study we evaluated the udder health status of 98 Holstein Friesian dairy cows with high SCC in 4 farms. From each cow a sample of milk was collected from all the functional quarters and submitted to bacteriological culture, SCC and Mycoplasma spp. culture. A thermographic image was taken from each functional udder quarter and nipple. Pearson's correlations and Analysis of Variance were performed in order to evaluate the different diagnostic techniques. The most frequent pathogen isolated was Staphylococcus aureus followed by Coagulase Negative Staphylococci (CNS), Streptococcus uberis, Streptococcus agalactiae and others. The Somatic Cell Score (SCS) was able to discriminate (p<0.05) cows positive for a pathogen from cows negative at the bacteriological culture except for cows with infection caused by CNS. Infrared thermography was correlated to SCS (p<0.05) but was not able to discriminate between positive and negative cows. Thermographic imaging seems to be promising in evaluating the inflammation status of cows affected by subclinical mastitis but seems to have a poor diagnostic value.

WARRANT OFFICER AND CIVILIAN HOUSING, QUARTERS L FRONT ELEVATION W/POLE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

WARRANT OFFICER AND CIVILIAN HOUSING, QUARTERS L FRONT ELEVATION W/POLE. - Naval Magazine Lualualei, Headquarters Branch, Warrant Officer's & Civilians Quarters Type, Along Sixty-sixth Street between Amberjack & Constitution Streets, Pearl City, Honolulu County, HI

Quarterly coal report, October--December 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-23

The Quarterly Coal Report (QCR) provides comprehensive information about US coal production, distribution, exports, imports, receipts, prices, consumption, and stocks to a wide audience, including Congress, Federal and State agencies, the coal industry, and the general public. Coke production, consumption, distribution, imports, and exports data are also provided. The data presented in the QCR are collected and published by the Energy Information Administration (EIA) to fulfill data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275), as amended. This report presents detailed quarterly data for October through December 1994 and aggregated quarterlymore » historical data for 1986 through the third quarter of 1994. Appendix A displays, from 1986 on, detailed quarterly historical coal imports data, as specified in Section 202 of the Energy Policy and Conservation Amendments Act of 1985 (Public Law 99-58). Appendix B gives selected quarterly tables converted to metric tons.« less

Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

PubMed Central

Liao, Jing; Zhang, Yingying; Gu, Hongcang; Bock, Christoph; Boyle, Patrick; Epstein, Charles B.; Bernstein, Bradley E.; Lengauer, Thomas; Gnirke, Andreas; Meissner, Alexander

2011-01-01

DNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the total DNA methylation content in human and mouse cells. While the genomic distribution, inter-individual stability, and functional role of CpG methylation are reasonably well understood, little is known about DNA methylation targeting CpA, CpT, and CpC (non-CpG) dinucleotides. Here we report a comprehensive analysis of non-CpG methylation in 76 genome-scale DNA methylation maps across pluripotent and differentiated human cell types. We confirm non-CpG methylation to be predominantly present in pluripotent cell types and observe a decrease upon differentiation and near complete absence in various somatic cell types. Although no function has been assigned to it in pluripotency, our data highlight that non-CpG methylation patterns reappear upon iPS cell reprogramming. Intriguingly, the patterns are highly variable and show little conservation between different pluripotent cell lines. We find a strong correlation of non-CpG methylation and DNMT3 expression levels while showing statistical independence of non-CpG methylation from pluripotency associated gene expression. In line with these findings, we show that knockdown of DNMTA and DNMT3B in hESCs results in a global reduction of non-CpG methylation. Finally, non-CpG methylation appears to be spatially correlated with CpG methylation. In summary these results contribute further to our understanding of cytosine methylation patterns in human cells using a large representative sample set. PMID:22174693

Evaluation of catastrophic musculoskeletal injuries in Thoroughbreds and Quarter Horses at three Midwestern racetracks.

PubMed

Beisser, Andrea L; McClure, Scott; Wang, Chong; Soring, Keith; Garrison, Rudy; Peckham, Bryce

2011-11-01

To determine the incidence of and compare the types of catastrophic musculoskeletal injuries (CMIs) sustained in Thoroughbreds and Quarter Horses during racing at 3 Midwestern racetracks from 2000 to 2006. Retrospective cohort study. 139 Thoroughbred and 50 Quarter Horse racehorses euthanized because of CMIs. Veterinary officials from 3 Midwestern racing jurisdictions provided injury reports for Thoroughbreds and Quarter Horses that sustained CMIs (which required euthanasia) and the total number of race starts for each year. The number of CMIs/1,000 starts was determined for each racetrack. Past performance reports for each horse with a CMI were evaluated. The total number of race starts (both breeds) at the 3 racetracks from 2000 through 2006 was 129,460, with an overall incidence of 1.46 CMIs/1,000 race starts. Incidences of CMIs among racetracks were similar. Of horses that sustained a CMI, the median age of Thoroughbreds at first race was 3 years, compared with a median age of 2 years for Quarter Horses. A larger proportion of Thoroughbreds sustained a CMI in a claiming race than did Quarter Horses, and a larger proportion of Quarter Horses sustained a CMI in a futurity trial than did Thoroughbreds. The most common site for CMIs in Thoroughbreds was the left forelimb (69/124 [55.6%]), whereas most CMIs in Quarter Horses involved the right forelimb (18/30 [60.0%]). Differences identified between CMIs in Thoroughbred and Quarter Horse racehorses should allow veterinarians to focus on horses and anatomic regions of greatest risk of CMI during racing.

Genetics Home Reference: fragile X-associated primary ovarian insufficiency

MedlinePlus

... a quarter of them develop the condition. FXPOI accounts for about 4 to 6 percent of all cases of primary ovarian insufficiency in women. Related Information What information about a genetic condition can statistics ...

Morphopathological features in tissues of alpha-mannosidosis guinea pigs at different gestational ages.

PubMed

Auclair, D; Hopwood, J J

2007-10-01

Alpha-mannosidosis is an inherited metabolic disorder characterized by a reduction in alpha-D-mannosidase and intralysosomal accumulation of undegraded mannose-containing oligosaccharides. The alpha-mannosidosis guinea pig exhibits pathological similarities to its human counterpart, which make it a valuable animal model. To trace the progression of alpha-mannosidosis during foetal development, brain and visceral organs from affected and unaffected guinea pigs at 30, 36, 38, 51 and 65 days of gestation (dg) were examined by light and electron microscopy (term: approximately 68 dg). In the affected brain, distended lysosomes (vacuoles) were scarce up to 38 dg and were seen in few differentiating neuronal cells but mostly in macrophages, pericytes and endothelial cells. At 51 and 65 dg, several vacuoles were observed in some neurones, in many Purkinje cells, pericytes, endothelial and microglial cells, and in few cerebellar internal granule cells. Myelination had started by 51 dg. Non-myelinated axonal spheroids were detected in the brainstem at 65 dg. In the kidney cortex and liver, an increase in vacuolation was noticed between 36 and 65 dg. Some vacuolated cells were also noticed in the lungs and spleen at 51 and 65 dg. Altogether, these histological observations suggest that alpha-mannosidosis is unlikely to affect ontogenesis before the second half of gestation in guinea pigs; however, the morphopathological features recorded during the last quarter of gestation (which may roughly correspond to the period covering near term to 1-2 years of age in human) were clearly noticeable and may have had some impact.

Reproductive Performance, Udder Health, and Antibiotic Resistance in Mastitis Bacteria isolated from Norwegian Red cows in Conventional and Organic Farming

PubMed Central

2010-01-01

Background The objectives of this study were to investigate whether there were differences between Norwegian Red cows in conventional and organic farming with respect to reproductive performance, udder health, and antibiotic resistance in udder pathogens. Methods Twenty-five conventional and 24 organic herds from south-east and middle Norway participated in the study. Herds were matched such that geographical location, herd size, and barn types were similar across the cohorts. All organic herds were certified as organic between 1997 and 2003. All herds were members of the Norwegian Dairy Herd Recording System. The herds were visited once during the study. The relationship between the outcomes and explanatory variables were assessed using mixed linear models. Results There were less > 2nd parity cows in conventional farming. The conventional cows had higher milk yields and received more concentrates than organic cows. Although after adjustment for milk yield and parity, somatic cell count was lower in organic cows than conventional cows. There was a higher proportion of quarters that were dried off at the herd visit in organic herds. No differences in the interval to first AI, interval to last AI or calving interval was revealed between organic and conventional cows. There was no difference between conventional and organic cows in quarter samples positive for mastitis bacteria from the herd visit. Milk yield and parity were associated with the likelihood of at least one quarter positive for mastitis bacteria. There was few S. aureus isolates resistance to penicillin in both management systems. Penicillin resistance against Coagulase negative staphylococci isolated from subclinically infected quarters was 48.5% in conventional herds and 46.5% in organic herds. Conclusion There were no large differences between reproductive performance and udder health between conventional and organic farming for Norwegian Red cows. PMID:20141638

Beyond Fossil Fuels: Options and Challenges

NASA Astrophysics Data System (ADS)

Thompson, Levi T.

2007-05-01

Securing our nation’s energy supply is arguably the most important challenge we face. The source and amount of energy that is available impacts nearly every aspect of our lives including our mobility, health and welfare. Presently, the U.S. depends heavily on foreign energy resources. For example, in 2006, nearly 60 percent of the crude oil consumed in the U.S. was imported; approximately one-quarter of this oil comes from the Persian Gulf. With growing demands from emerging economies, declining environmental quality and potential for global conflict, there is a pressing need to develop a more sustainable energy strategy. This presentation will review options for a sustainable energy economy including the use of hydrogen and fuel cells, and describe some of the key challenges To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.OSS07.A1.2

Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division: July--September 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jubin, R.T.

This report summarizes the major activities conducted in the Chemical and Energy Research Section of the Chemical Technology Division at Oak Ridge National Laboratory (ORNL) during the period July--September 1997. The section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within nine major areas of research: Hot Cell Operations, Process Chemistry and Thermodynamics, Molten Salt Reactor Experiment (MSRE) Remediation Studies, Chemistry Research, Biotechnology, Separations and Materials Synthesis, Fluid Structure and Properties, Biotechnologymore » Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.« less

Beam steering for virtual/augmented reality displays with a cycloidal diffractive waveplate.

PubMed

Chen, Haiwei; Weng, Yishi; Xu, Daming; Tabiryan, Nelson V; Wu, Shin-Tson

2016-04-04

We proposed a switchable beam steering device with cycloidal diffractive waveplate (CDW) for eye tracking in a virtual reality (VR) or augmented reality (AR) display system. Such a CDW diffracts the incident circularly polarized light to the first order with over 95% efficiency. To convert the input linearly polarized light to right-handed or left-handed circular polarization, we developed a broadband polarization switch consisting of a twisted nematic liquid crystal cell and an achromatic quarter-wave retardation film. By cascading 2-3 CDWs together, multiple diffraction angles can be achieved. To suppress the color dispersion, we proposed two approaches to obtain the same diffraction angle for red, green, and blue LEDs-based full color displays. Our device exhibits several advantages, such as high diffraction efficiency, fast response time, low power consumption, and low cost. It holds promise for the emerging VR/AR displays.

Homeodomains, Hedgehogs, and Happiness.

PubMed

Scott, Matthew P

2016-01-01

Developmental biologists have had a spectacular quarter century of discoveries, building on many decades of work earlier, discovering molecular, cellular, and genetic mechanisms that underlie the magical process by which an egg becomes a plant or animal. Among the discoveries were homeodomains, DNA-binding domains that allow transcription factors to recognize their target genes, and the Hedgehog signaling pathway, which is used in many organs and tissues for communication among cells. The experience of unveiling the mechanisms and molecules connected to both of these findings has been remarkable, joyful, difficult, and a time of great teamwork and collaboration within and between laboratory groups. More than ever it is possible to discern the evolutionary processes, and their mechanisms, that led to the diversity of life on earth. A huge amount of work remains to be done to obtain a broad understanding of what happened and how development works. © 2016 Elsevier Inc. All rights reserved.

Designing nucleosomal force sensors

NASA Astrophysics Data System (ADS)

Tompitak, M.; de Bruin, L.; Eslami-Mossallam, B.; Schiessel, H.

2017-05-01

About three quarters of our DNA is wrapped into nucleosomes: DNA spools with a protein core. It is well known that the affinity of a given DNA stretch to be incorporated into a nucleosome depends on the geometry and elasticity of the basepair sequence involved, causing the positioning of nucleosomes. Here we show that DNA elasticity can have a much deeper effect on nucleosomes than just their positioning: it affects their "identities". Employing a recently developed computational algorithm, the mutation Monte Carlo method, we design nucleosomes with surprising physical characteristics. Unlike any other nucleosomes studied so far, these nucleosomes are short-lived when put under mechanical tension whereas other physical properties are largely unaffected. This suggests that the nucleosome, the most abundant DNA-protein complex in our cells, might more properly be considered a class of complexes with a wide array of physical properties, and raises the possibility that evolution has shaped various nucleosome species according to their genomic context.

Barriers to the clinical translation of orthopedic tissue engineering.

PubMed

Evans, Christopher H

2011-12-01

Tissue engineering and regenerative medicine have been the subject of increasingly intensive research for over 20 years, and there is concern in some quarters over the lack of clinically useful products despite the large sums of money invested. This review provides one perspective on orthopedic applications from a biologist working in academia. It is suggested that the delay in clinical application is not atypical of new, biologically based technologies. Some barriers to progress are acknowledged and discussed, but it is also noted that preclinical studies have identified several promising types of cells, scaffolds, and morphogenetic signals, which, although not optimal, are worth advancing toward human trials to establish a bridgehead in the clinic. Although this transitional technology will be replaced by more sophisticated, subsequent systems, it will perform valuable pioneering functions and facilitate the clinical development of the field. Some strategies for achieving this are suggested. © Mary Ann Liebert, Inc.

Environmental gram-positive mastitis treatment: in vitro sensitivity and bacteriologic cure.

PubMed

Cattell, M B; Dinsmore, R P; Belschner, A P; Carmen, J; Goodell, G

2001-09-01

A clinical trial was conducted in a large dairy herd to determine the efficacy of intramammary pirlimycin hydrochloride administration during lactation for bacteriologic clearance of gram-positive environmental clinical and subclinical mastitis infections. Quarters infected with environmental streptococci that received pirlimycin therapy (13/28) were 1.8 times more likely to resolve infection than untreated quarters (5/14). The small numbers of quarters infected with coagulase-negative staphylococci resulted in inadequate power to assess treatment differences in cure rate. Although the association was not statistically significant, quarters from cows with sensitive environmental streptococci isolates from composite samples (8/13) resolved infection with treatment at approximately twice the rate of treated quarters with resistant isolates (3/10).

Effect of 2 herbal intramammary products on milk quantity and quality compared with conventional and no dry cow therapy.

PubMed

Mullen, K A E; Anderson, K L; Washburn, S P

2014-01-01

Dry cow therapy, administered at the end of lactation, is aimed at eliminating current and preventing future intramammary (IMM) bacterial infections and typically involves intramammary administration of antibiotics. Certified organic dairies in the United States are restricted from using antibiotics and must consider an alternative therapy or no dry cow therapy. The current study compared 2 herbal products to conventional dry cow therapy and no treatment for a total of 5 treatments over 2 trials. Trial 1 was conducted over 3 yr on 1 research farm and trial 2 included 4 commercial farms plus the research herd over 2 yr. Treatments included (1) a conventional IMM antibiotic and internal teat sealant (penicillin-dihydrostreptomycin and bismuth subnitrate; CON); (2) an herbal IMM product purported to act as a teat sealant (Cinnatube, New AgriTech Enterprises, Locke, NY; CIN); (3) an herbal IMM product (Phyto-Mast, Bovinity Health LLC, Narvon, PA; P-M); (4) Phyto-Mast and Cinnatube (PC); or (5) no dry cow therapy (NT). Each treatment group was balanced by breed, lactation number, due date, herd, and year. However, the CON treatment was used only in the research herd because of the intent to avoid antibiotic usage on the other 4 farms. Comparisons among treatments included the difference between pre- and posttreatment 305-d mature equivalent milk production (trial 1), somatic cell score change from dry-off to freshening at the cow and quarter levels (trials 1 and 2), and milk microbiology change over the dry period (trial 2). We detected no significant differences among treatments for milk yield differences between the lactation following treatment and the lactation preceding treatment. Changes in somatic cell score from one lactation to the next also did not differ significantly among treatments in either trial. Cure rates were not significantly different among treatments; only 19.6% of all quarters were infected at dry off. The proportion of quarters with new infections at 3 to 5d postcalving did not significantly differ among treatments, except between CIN and NT. Percentages (least squares means ± standard error) of quarters with new infections were 24 ± 21% for CON, 15 ± 7% for CIN, 30 ± 10% for P-M, 32 ± 11% for PC, and 35 ± 11% for NT. The efficacy of the herbal products was similar to that of conventional therapy, and the herbal products had no apparent adverse effects. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Idaho National Laboratory Quarterly Performance Analysis for the 2nd Quarter FY 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Lisbeth A.

2015-04-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of events for the 2nd Qtr FY-15.

Relative age effect and Yo-Yo IR1 in youth soccer.

PubMed

Deprez, D; Vaeyens, R; Coutts, A J; Lenoir, M; Philippaerts, R

2012-12-01

The aims of the study were to investigate the presence of a relative age effect and the influence of birth quarter on anthropometric characteristics, an estimation of biological maturity and performance in the Yo-Yo Intermittent Recovery Test level 1 in 606 elite, Flemish youth soccer players. The sample was divided into 5 chronological age groups (U10-U19), each subdivided into 4 birth quarters. Players had their APHV estimated and height, weight and Yo-Yo IR1 performance were assessed. Differences between quarters were investigated using uni- and multivariate analyses. Overall, significantly (P<0.001) more players were born in the first quarter (37.6%) compared to the last (13.2%). Further, no significant differences in anthropometric variables and Yo-Yo IR1 performance were found between the 4 birth quarters. However, there was a trend for players born in the first quarter being taller and heavier than players born in the fourth quarter. Players born in the last quarter tended to experience their peak in growth earlier, this may have enabled them to compete physically with their relatively older peers. Our results indicated selection procedures which are focused on the formation of strong physical and physiological homogeneous groups. Relative age and individual biological maturation should be considered when selecting adolescent soccer players. © Georg Thieme Verlag KG Stuttgart · New York.

77 FR 38211 - Rescission of Quarterly Financial Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... No. FMCSA-2012-0020] RIN-2126-AB48 Rescission of Quarterly Financial Reporting Requirements AGENCY..., the Federal Motor Carrier Safety Administration (FMCSA) eliminates the quarterly financial reporting... would be ineffective or unacceptable without a change. III. Background Annual Financial Reporting...

78 FR 31475 - Rescission of Quarterly Financial Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... No. FMCSA-2012-0020] RIN-2126-AB48 Rescission of Quarterly Financial Reporting Requirements AGENCY...); request for comments. SUMMARY: FMCSA proposes to eliminate the quarterly financial reporting requirements... person argued that the financial reporting requirements transferred from the Interstate Commerce...

ER Consolidated Qtrly Rpt_April-June 2016_October 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2016-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the April, May, and June 2016 quarterly reporting period.

(Development of advanced models of the MCC full expansion (quiet) engine): First quarterly report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This is the first quarterly report to the Department of Energy on the progress associated with the development of advanced models of the MCC full expansion (quiet) engine. These models will be evaluated in successive steps and eventually incorporated into a lawn mower for the purpose of commercializing the engine for small wheeled lawn and garden applications. During the first three months of the program (July 1 thru Sept 30), the Phase I design was basically completed with the exception of some engine/lawn mower interface hardware which will be completed during the final stages of the development program after wemore » have selected a lawn mower deck. Rick Erickson, the design engineer for the program, completed the initial parts drawings utilizing the computer drafting system together with guidance from Fredrick Erickson, the program principal engineer and Jeff Erickson, who is in charge of manufacturing the engines. A miniature copy of these drawings is included in the appendix for your review.« less

03pd2813

NASA Image and Video Library

2003-10-15

October 15, 2003. Cosmonaut Hotel, Baikonur, Kazakhstan. Expedition 8 Commander and NASA Science Officer Mike Foale talks to a colleague on his cell phone from his Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan Oct. 15, 2003 as he continues prelaunch preparations for his launch on Oct. 18 on a Soyuz TMA-3 vehicle to the International Space Station. Foale will ride into orbit with Expedition 8 Soyuz Commander Alexander Kaleri and European Space Agency Astronaut Pedro Duuque of Spain. Photo Credit: "NASA/Bill Ingalls"

TechSolutions 11: An Introduction to Power and Energy

DTIC Science & Technology

2009-01-01

facilitate ionic conduction under hydrated conditions. The operating temperature for PEMFCs is relatively cool (70°C). The reactions on the anode and...cathode side of the FC are the same as those shown for PAFCs. Direct methanol fuel cells (DMFCs) are a subset of PEMFCs . These FCs utilize the same...an electrically E58 The AMMTIAC Quarterly, Volume 4, Number 1 Figure 7. Diagram of a PEMFC .[47] 1 Hydrogen fuel is channeled through field flow

F-Area Acid/Caustic Basin groundwater monitoring report. First quarter 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-06-01

During first quarter 1995, samples from the FAC monitoring wells at the F-Area Acid/Caustic Basin were collected and analyzed for herbicides/pesticides, indicator parameters, metals, nitrate, radionuclide indicators, volatile organic compounds, and other constituents. Piezometer FAC 5P and monitoring well FAC 6 were dry and could not be sampled. New monitoring wells FAC 9C, 10C, 11C, and 12C were completed in the Barnwell/McBean aquifer and were sampled for the first time during third quarter 1994 (first quarter 1995 is the third of four quarters of data required to support the closure of the basin). Analytical results that exceeded final Primary Drinkingmore » Water Standards (PDWS), other Savannah River Site (SRS) Flag 2 criteria, or the SRS turbidity standard of 50 NTU during the quarter were as follows: gross alpha exceeded the final PDWS and aluminum, iron, manganese, and total alpha-emitting radium exceeded the SRS Flag 2 criteria in one or more of the FAC wells. Turbidity exceeded the SRS standard (50 NTU) in wells FAC 3 and 11C. Groundwater flow direction and rate in the water table beneath the F-Area Acid/Caustic Basin were similar to past quarters.« less

Programmatic Research to Develop and Disseminate Improved Instructional Technology for Handicapped Children. Project MORE Quarterly Progress Report, September 1 to December 1, 1972.

ERIC Educational Resources Information Center

Schiefelbusch, Richard L.; Lent, James R.

During the past reporting period the curriculum development staff of Project MORE (Mediated Operational Research for Education) has made substantial progress in attaining its program objectives. Design and development phases have proceeded on schedule. Four programs are currently in the field-testing stage, and four others are under development.…

SLAVE QUARTERS (RESTORED). This is the north building, one of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SLAVE QUARTERS (RESTORED). This is the north building, one of the two identical buildings in the plantation. Each building has a 2-room plan. - Hopsewee Plantation, Slave Quarters, U.S. Routes 17 & 701, Santee River, North, Georgetown, Georgetown County, SC

CSSEDC Quarterly. 1990.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1990-01-01

These four issues of the CSSEDC Quarterly (Conference for Secondary School English Department Chairpersons) represent the quarterly for 1990. Articles in number 1 deal with student teachers and include: "Student Teaching: Smoothing Out the Rough Spots" (Susan B. Argyle and Fred C. Feitler); "A Partnership for Urban Student…

Calorimetry exchange program amendment to 3rd quarter CY92 report LLNL isotopic data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnett, T.M.

1996-08-01

This report is a series of ammendments to the Calorimetry Exchange Quarterly Data Report for third quarter CY1992. The ammendment is needed due to reporting errors encountered in the Lawrence Livermore National Laboratory isotopic data.

5 CFR 332.311 - Quarterly examinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Quarterly examinations. 332.311 Section... AND SELECTION THROUGH COMPETITIVE EXAMINATION Period of Competition and Eligibility Acceptance of Applications After Closing Date of Examinations § 332.311 Quarterly examinations. (a) A 10-point preference...

Quarterly Coal Distribution

EIA Publications

2017-01-01

The Quarterly Coal Distribution Report (QCDR) provides detailed U.S. domestic coal distribution data by coal origin state, coal destination state, mode of transportation, and consuming sector. Quarterly data for all years are preliminary and will be superseded by the release of the corresponding Annual Coal Distribution Report.

75 FR 17462 - Quarterly Rail Cost Adjustment Factor

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... decision may be purchased by contacting the office of Public Assistance, Governmental Affairs, and...-2)] Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the second quarter 2010 Rail Cost...

The Savannah River Site's Groundwater Monitoring Program, third quarter 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During third quarter 1991, EPD/EMS conducted extensive sampling of monitoring wells. Analytical results from third quarter 1991 are listed in this report.

English Leadership Quarterly. 1991.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1991-01-01

These four issues of the English Leadership Quarterly represent the quarterly for 1991. Articles in number 1 deal with whole language and include: "CEL: Shorter and Better" (Myles D. Eley); "Toward a New Philosophy of Language Learning" (Kathleen Strickland); "Whole Language: Implications for Secondary Classrooms"…

Idaho National Laboratory Quarterly Performance Analysis - 2nd Quarter FY2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lisbeth A. Mitchell

2014-06-01

This report is published quarterly by the Idaho National Laboratory (INL) Performance Assurance Organization. The Department of Energy Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of occurrence reports and other deficiency reports (including not reportable events) identified at INL from January 2014 through March 2014.

Defense Attache Saigon: RNAVF Quarterly Assessment. 2nd Quarter FY74.

DTIC Science & Technology

1974-02-01

Military Assistance Command Vietnam MAP Military Assistance Program UNCLASSIFIED F IUNCLASSIFIES MASI Military Assistance Service Funded MATT Military Air...8217 operating the school. The average yearly budget is 2,~4oo,000 piasters, whiuh averages out to less than five cents per student per day. This is... average daily cargo handling rate of 959 M/T for the 2nd quarter FY711 shows continued improvement over the 773 M/T rate attained during the 1st quarter

Quantum Decision Theory in Simple Risky Choices.

PubMed

Favre, Maroussia; Wittwer, Amrei; Heinimann, Hans Rudolf; Yukalov, Vyacheslav I; Sornette, Didier

2016-01-01

Quantum decision theory (QDT) is a recently developed theory of decision making based on the mathematics of Hilbert spaces, a framework known in physics for its application to quantum mechanics. This framework formalizes the concept of uncertainty and other effects that are particularly manifest in cognitive processes, which makes it well suited for the study of decision making. QDT describes a decision maker's choice as a stochastic event occurring with a probability that is the sum of an objective utility factor and a subjective attraction factor. QDT offers a prediction for the average effect of subjectivity on decision makers, the quarter law. We examine individual and aggregated (group) data, and find that the results are in good agreement with the quarter law at the level of groups. At the individual level, it appears that the quarter law could be refined in order to reflect individual characteristics. This article revisits the formalism of QDT along a concrete example and offers a practical guide to researchers who are interested in applying QDT to a dataset of binary lotteries in the domain of gains.

Quantum Decision Theory in Simple Risky Choices

PubMed Central

Favre, Maroussia; Wittwer, Amrei; Heinimann, Hans Rudolf; Yukalov, Vyacheslav I.; Sornette, Didier

2016-01-01

Quantum decision theory (QDT) is a recently developed theory of decision making based on the mathematics of Hilbert spaces, a framework known in physics for its application to quantum mechanics. This framework formalizes the concept of uncertainty and other effects that are particularly manifest in cognitive processes, which makes it well suited for the study of decision making. QDT describes a decision maker’s choice as a stochastic event occurring with a probability that is the sum of an objective utility factor and a subjective attraction factor. QDT offers a prediction for the average effect of subjectivity on decision makers, the quarter law. We examine individual and aggregated (group) data, and find that the results are in good agreement with the quarter law at the level of groups. At the individual level, it appears that the quarter law could be refined in order to reflect individual characteristics. This article revisits the formalism of QDT along a concrete example and offers a practical guide to researchers who are interested in applying QDT to a dataset of binary lotteries in the domain of gains. PMID:27936217

International petroleum statistics report, February 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-02-01

The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual datamore » for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995. 4 figs., 47 tabs.« less

International petroleum statistics report, November 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-11-01

The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual datamore » for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1997; OECD stocks from 1973 through 1997; and OECD trade from 1987 through 1997. 4 figs., 46 tabs.« less

International petroleum statistics report, June 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual datamore » for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1997; OECD stocks from 1973 through 1997; and OECD trade from 1987 through 1997. 4 figs., 48 tabs.« less

Models of MOS and SOS devices

NASA Technical Reports Server (NTRS)

Gassaway, J. D.; Mahmood, Q.; Trotter, J. D.

1980-01-01

Quarterly report describes progress in three programs: dc sputtering machine for aluminum and aluminum alloys; two dimensional computer modeling of MOS transistors; and development of computer techniques for calculating redistribution diffusion of dopants in silicon on sapphire films.

Catfishes

USDA-ARS?s Scientific Manuscript database

Catfishes are esteemed and popular foodfish throughout much of the world. Important commercial and subsistence fisheries exist in Europe, Asia, Africa, and North and South America. The popularity of catfishes as food stimulated rapid development of catfish aquaculture in the past quarter century. Ap...

75 FR 11565 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... NATIONAL COUNCIL ON DISABILITY Sunshine Act Meetings Type: Quarterly Meeting. Dates and Times.... Agenda: Public Comment Sessions; Emergency Management; Developmental Disabilities and Bill of Rights Act, International Development, National Summit on Disability Policy 2010, United States Marine Corps Research...

National Geothermal Academy. Geo-Heat Center Quarterly Bulletin, Vol. 31 No. 2 (Complete Bulletin). A Quarterly Progress and Development Report on the Direct Utilization of Geothermal Resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, Tonya; Maddi, Phillip

2012-08-01

The National Geothermal Academy (NGA) is an intensive 8-week overview of the different aspects involved in developing a geothermal project, hosted at University of Nevada, Reno. The class of 2012 was the second graduating class from the academy and included 21 students from nine states, as well as Saudi Arabia, Dominica, India, Trinidad, Mexico. The class consisted of people from a wide range of scholastic abilities from students pursuing a Bachelor’s or Master’s degrees, to entrepreneurs and professionals looking to improve their knowledge in the geothermal field. Students earned 6 credits, either undergraduate or graduate, in engineering or geology. Overall,more » the students of the NGA, although having diverse backgrounds in engineering, geology, finance, and other sciences, came together with a common passion to learn more about geothermal.« less