Education at the National Academies

ERIC Educational Resources Information Center

Labov, Jay B.

2003-01-01

The past three issues of "Cell Biology Education" (CBE) have provided overviews of education projects within the National Research Council's (NRC's) Center for Education, Board on Life Sciences, National Academy of Engineering, and National Academy of Science's Office of Public Understanding of Science. In this article, the author provides…

Hydrogen-bonded LbL Shells for Living Cell Surface Engineering

DTIC Science & Technology

2011-03-21

unicellular organism duplicates, i.e., one cell produces two in a given period of time (see divided cells as indicated by arrows in Fig. 10c). During...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Georgia Institute of Technology,School of Materials Science and Engineering,Atlanta,GA,30332 8...PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT

Nano scaffolds and stem cell therapy in liver tissue engineering

NASA Astrophysics Data System (ADS)

Montaser, Laila M.; Fawzy, Sherin M.

2015-08-01

Tissue engineering and regenerative medicine have been constantly developing of late due to the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Although stem cells hold great potential for the treatment of many injuries and degenerative diseases, several obstacles must be overcome before their therapeutic application can be realized. These include the development of advanced techniques to understand and control functions of micro environmental signals and novel methods to track and guide transplanted stem cells. A major complication encountered with stem cell therapies has been the failure of injected cells to engraft to target tissues. The application of nanotechnology to stem cell biology would be able to address those challenges. Combinations of stem cell therapy and nanotechnology in tissue engineering and regenerative medicine have achieved significant advances. These combinations allow nanotechnology to engineer scaffolds with various features to control stem cell fate decisions. Fabrication of Nano fiber cell scaffolds onto which stem cells can adhere and spread, forming a niche-like microenvironment which can guide stem cells to proceed to heal damaged tissues. In this paper, current and emergent approach based on stem cells in the field of liver tissue engineering is presented for specific application. The combination of stem cells and tissue engineering opens new perspectives in tissue regeneration for stem cell therapy because of the potential to control stem cell behavior with the physical and chemical characteristics of the engineered scaffold environment.

Recombinant DNA Paper Model Simulation: The Genetic Engineer.

ERIC Educational Resources Information Center

Wagner, Joan

1998-01-01

Describes a course for talented high school students that focuses on DNA science and technology. Employs Cold Spring Harbor's DNA Science laboratory manual. Engages students in performing sickle-cell anemia and thalassemia tests in rabbits. (DDR)

Tissue engineering and regenerative medicine in applied research: a year in review of 2014.

PubMed

Lin, Xunxun; Huang, Jia; Shi, Yuan; Liu, Wei

2015-04-01

Tissue engineering and regenerative medicine (TERM) remains to be one of the fastest growing fields, which covers a wide scope of topics of both basic and applied biological researches. This overview article summarized the advancements in applied researches of TERM area, including stem cell-mediated tissue regeneration, material science, and TERM clinical trial. These achievements demonstrated the great potential of clinical regenerative therapy of tissue/organ disease or defect through stem cells and tissue engineering approaches.

Box 11: Tissue Engineering and Bioscience Methods Using Proton Beam Writing

NASA Astrophysics Data System (ADS)

van Kan, J. A.

Tissue engineering is a rapidly developing and highly interdisciplinary field that applies the principles of cell biology, engineering, and materials science to the culture of biological tissue. The artificially grown tissue then can be implanted directly into the body, or it can form part of a device that replaces organ functionality.

Biomaterials for Bone Regenerative Engineering.

PubMed

Yu, Xiaohua; Tang, Xiaoyan; Gohil, Shalini V; Laurencin, Cato T

2015-06-24

Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the "tissue engineering" concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as "regenerative engineering". In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Tissue engineering of reproductive tissues and organs.

PubMed

Atala, Anthony

2012-07-01

Regenerative medicine and tissue engineering technology may soon offer new hope for patients with serious injuries and end-stage reproductive organ failure. Scientists are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that can restore and maintain normal function in diseased and injured reproductive tissues. In addition, the stem cell field is advancing, and new discoveries in this field will lead to new therapeutic strategies. For example, newly discovered types of stem cells have been retrieved from uterine tissues such as amniotic fluid and placental stem cells. The process of therapeutic cloning and the creation of induced pluripotent cells provide still other potential sources of stem cells for cell-based tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This article discusses these tissue engineering strategies for various organs in the male and female reproductive tract. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy

PubMed Central

Hipp, Jason; Atala, Anthony

2004-01-01

Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure. PMID:15588286

Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy.

PubMed

Hipp, Jason; Atala, Anthony

2004-12-08

: BACKGROUND: Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

Therapeutic cloning applications for organ transplantation.

PubMed

Koh, Chester J; Atala, Anthony

2004-04-01

A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure. Copyright 2004 Elsevier B.V.

Chemical and Enzymatic Strategies for Bacterial and Mammalian Cell Surface Engineering.

PubMed

Bi, Xiaobao; Yin, Juan; Chen Guanbang, Ashley; Liu, Chuan-Fa

2018-06-07

The cell surface serves important functions such as the regulation of cell-cell and cell-environment interactions. The understanding and manipulation of the cell surface is important for a wide range of fundamental studies of cellular behavior and for biotechnological and medical applications. With the rapid advance of biology, chemistry and materials science, many strategies have been developed for the functionalization of bacterial and mammalian cell surfaces. Here, we review the recent development of chemical and enzymatic approaches to cell surface engineering with particular emphasis on discussing the advantages and limitations of each of these strategies. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Cell engineering: spearheading the next generation in healthcare.

PubMed

Jayasinghe, Suwan N

2008-09-01

Manipulating living mammalian cells present fascinating possibilities for a plethora of applications within our healthcare. These imply several possibilities in tissue engineering and regenerative medicine, to those of a therapeutic nature. The physical sciences are increasingly playing a pivotal role in this endeavour by both advancing existing cell engineering technology and pioneering new protocols for the creation of biologically viable structures. In this paper, the author introduces several direct needle/channel/orifice-based cell engineering protocols, currently undergoing intense investigation for a whole host of bio-applications. Hence, each protocol's advantages and disadvantages are clearly identified, whilst recognizing their future biological and engineering challenges. In conclusion, a few selected biotechnological applications present possibilities where these protocols could undergo focused exploration. Successful development of these bio-protocols sees the emergence of unique future strategies within a clinical environment having far-reaching consequences for our healthcare.

Engineering and physical sciences in oncology: challenges and opportunities

PubMed Central

Mitchell, Michael J.; Jain, Rakesh K.; Langer, Robert

2017-01-01

The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas. PMID:29026204

The Quest toward limb regeneration: a regenerative engineering approach

PubMed Central

Laurencin, Cato T.; Nair, Lakshmi S.

2016-01-01

The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb. The remarkable advances in the scientific understanding of regeneration, stem cell science, material science and engineering, physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing. Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration. PMID:27047679

Engineering approaches to immunotherapy.

PubMed

Swartz, Melody A; Hirosue, Sachiko; Hubbell, Jeffrey A

2012-08-22

As the science of immunology grows increasingly mechanistic, motivation for developing quantitative, design-based engineering approaches has also evolved, both for therapeutic interventions and for elucidating immunological pathways in human disease. This has seeded the nascent field of "immunoengineering," which seeks to apply engineering analyses and design approaches to problems in translational immunology. For example, cell engineers are creating ways to tailor and use immune cells as living therapeutics; protein engineers are devising new methods of rapid antibody discovery; biomaterials scientists are guiding vaccine delivery and immune-cell activation with novel constructs; and systems immunologists are deciphering the evolution and maintenance of T and B cell receptor repertoires, which could help guide vaccine design. The field is multidisciplinary and collaborative, with engineers and immunologists working together to better understand and treat disease. We discuss the scientific progress in this young, yet rapidly evolving research area, which has yielded numerous start-up companies that are betting on impact in clinical and commercial translation in the near future.

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

PubMed

Wu, Chia-Yung; Roybal, Kole T; Puchner, Elias M; Onuffer, James; Lim, Wendell A

2015-10-16

There is growing interest in using engineered cells as therapeutic agents. For example, synthetic chimeric antigen receptors (CARs) can redirect T cells to recognize and eliminate tumor cells expressing specific antigens. Despite promising clinical results, these engineered T cells can exhibit excessive activity that is difficult to control and can cause severe toxicity. We designed "ON-switch" CARs that enable small-molecule control over T cell therapeutic functions while still retaining antigen specificity. In these split receptors, antigen-binding and intracellular signaling components assemble only in the presence of a heterodimerizing small molecule. This titratable pharmacologic regulation could allow physicians to precisely control the timing, location, and dosage of T cell activity, thereby mitigating toxicity. This work illustrates the potential of combining cellular engineering with orthogonal chemical tools to yield safer therapeutic cells that tightly integrate cell-autonomous recognition and user control. Copyright © 2015, American Association for the Advancement of Science.

The Use of Mathematical Modelling for Improving the Tissue Engineering of Organs and Stem Cell Therapy.

PubMed

Lemon, Greg; Sjoqvist, Sebastian; Lim, Mei Ling; Feliu, Neus; Firsova, Alexandra B; Amin, Risul; Gustafsson, Ylva; Stuewer, Annika; Gubareva, Elena; Haag, Johannes; Jungebluth, Philipp; Macchiarini, Paolo

2016-01-01

Regenerative medicine is a multidisciplinary field where continued progress relies on the incorporation of a diverse set of technologies from a wide range of disciplines within medicine, science and engineering. This review describes how one such technique, mathematical modelling, can be utilised to improve the tissue engineering of organs and stem cell therapy. Several case studies, taken from research carried out by our group, ACTREM, demonstrate the utility of mechanistic mathematical models to help aid the design and optimisation of protocols in regenerative medicine.

Engineering Cellular Metabolism.

PubMed

Nielsen, Jens; Keasling, Jay D

2016-03-10

Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation. Copyright © 2016 Elsevier Inc. All rights reserved.

Tissue engineering in endodontics.

PubMed

Saber, Shehab El-Din M

2009-12-01

Tissue engineering is the science of design and manufacture of new tissues to replace impaired or damaged ones. The key ingredients for tissue engineering are stem cells, the morphogens or growth factors that regulate their differentiation, and a scaffold of extracellular matrix that constitutes the microenvironment for their growth. Recently, there has been increasing interest in applying the concept of tissue engineering to endodontics. The aim of this study was to review the body of knowledge related to dental pulp stem cells, the most common growth factors, and the scaffolds used to control their differentiation, and a clinical technique for the management of immature non-vital teeth based on this novel concept.

Vital roles of stem cells and biomaterials in skin tissue engineering.

PubMed

Mohd Hilmi, Abu Bakar; Halim, Ahmad Sukari

2015-03-26

Tissue engineering essentially refers to technology for growing new human tissue and is distinct from regenerative medicine. Currently, pieces of skin are already being fabricated for clinical use and many other tissue types may be fabricated in the future. Tissue engineering was first defined in 1987 by the United States National Science Foundation which critically discussed the future targets of bioengineering research and its consequences. The principles of tissue engineering are to initiate cell cultures in vitro, grow them on scaffolds in situ and transplant the composite into a recipient in vivo. From the beginning, scaffolds have been necessary in tissue engineering applications. Regardless, the latest technology has redirected established approaches by omitting scaffolds. Currently, scientists from diverse research institutes are engineering skin without scaffolds. Due to their advantageous properties, stem cells have robustly transformed the tissue engineering field as part of an engineered bilayered skin substitute that will later be discussed in detail. Additionally, utilizing biomaterials or skin replacement products in skin tissue engineering as strategy to successfully direct cell proliferation and differentiation as well as to optimize the safety of handling during grafting is beneficial. This approach has also led to the cells' application in developing the novel skin substitute that will be briefly explained in this review.

The use of bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for alveolar bone tissue engineering: basic science to clinical translation.

PubMed

Kagami, Hideaki; Agata, Hideki; Inoue, Minoru; Asahina, Izumi; Tojo, Arinobu; Yamashita, Naohide; Imai, Kohzoh

2014-06-01

Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. Human bone marrow stromal cells (BMSCs) are the most commonly used cell source for bone tissue engineering. Although it is known that cell culture and induction protocols significantly affect the in vivo bone forming ability of BMSCs, the responsible factors of clinical outcome are poorly understood. The results from recent studies using human BMSCs have shown that factors such as passage number and length of osteogenic induction significantly affect ectopic bone formation, although such differences hardly affected the alkaline phosphatase activity or gene expression of osteogenic markers. Application of basic fibroblast growth factor helped to maintain the in vivo osteogenic ability of BMSCs. Importantly, responsiveness of those factors should be tested under clinical circumstances to improve the bone tissue engineering further. In this review, clinical application of bone tissue engineering was reviewed with putative underlying mechanisms.

High pressure in bioscience and biotechnology: pure science encompassed in pursuit of value.

PubMed

Hayashi, Rikimaru

2002-03-25

A fundamental factors, pressure (P), is indispensable to develop and support applications in the field of bioscience and biotechnology. This short sentence describes an example how high pressure bioscience and biotechnology, which started from applied science, stimulates challenges of basic science and pure science in the biology-related fields including not only food science, medicine, and pharmacology but also biochemistry, molecular biology, cell biology, physical chemistry, and engineering.

Proceedings of the 25th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Phillips, M.

1985-01-01

Topics addressed include: silicon sheet growth and characterization, silicon material, process development, high-efficiency cells, environmental isolation, engineering sciences, and reliability physics.

Engineering tissues, organs and cells.

PubMed

Atala, Anthony

2007-01-01

Patients suffering from diseased and injured organs may be treated with transplanted organs; however, there is a severe shortage of donor organs that is worsening yearly, given the ageing population. In the field of regenerative medicine and tissue engineering, scientists apply the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy, including the use of amniotic and placental fetal stem cells. This review covers recent advances that have occurred in regenerative medicine and describes applications of these technologies using chemical compounds that may offer novel therapies for patients with end-stage organ failure. 2007 John Wiley & Sons, Ltd

Science Causes and Synergistic Engineering and Commercial Consequences of Movements of Fine Dust (MOFD) on the Moon

NASA Astrophysics Data System (ADS)

O'Brien, B. J.

2018-04-01

Failures 1969 Apollo 11 EASEP and 2014 Yutu immobilisation bookend engineering and operational consequences of movement of fine dust MOFD. So we challenge DTVCs to simulate decrease in situ dust over 25 hour data tranche DDE vertical silicon-covered cell.

The Five-Year Outlook on Science and Technology: 1982.

ERIC Educational Resources Information Center

National Academy of Sciences - National Research Council, Washington, DC. Committee on Science and Public Policy.

Presented are reports on trends and probable future developments in eight selected areas of basic science and engineering. These reports are: "The Genetic Program of Complex Organisms" (Maxine F. Singer); "The Molecular and Genetic Technology of Plants" (Joseph E. Varner); "Cell Receptors for Hormones and…

Tissue engineering of urinary bladder - current state of art and future perspectives.

PubMed

Adamowicz, Jan; Kowalczyk, Tomasz; Drewa, Tomasz

2013-01-01

Tissue engineering and biomaterials science currently offer the technology needed to replace the urinary tract wall. This review addresses current achievements and barriers for the regeneration of the urinary blad- der based on tissue engineering methods. Medline was search for urinary bladder tissue engineering regenerative medicine and stem cells. Numerous studies to develop a substitute for the native urinary bladder wall us- ing the tissue engineering approach are ongoing. Stem cells combined with biomaterials open new treatment methods, including even de novo urinary bladder construction. However, there are still many issues before advances in tissue engineering can be introduced for clinical application. Before tissue engineering techniques could be recognize as effective and safe for patients, more research stud- ies performed on large animal models and with long follow-up are needed to carry on in the future.

Label-Free Raman Hyperspectral Imaging of Single Cells Cultured on Polymer Substrates.

PubMed

Sinjab, Faris; Sicilia, Giovanna; Shipp, Dustin W; Marlow, Maria; Notingher, Ioan

2017-12-01

While Raman hyperspectral imaging has been widely used for label-free mapping of biomolecules in cells, these measurements require the cells to be cultured on weakly Raman scattering substrates. However, many applications in biological sciences and engineering require the cells to be cultured on polymer substrates that often generate large Raman scattering signals. Here, we discuss the theoretical limits of the signal-to-noise ratio in the Raman spectra of cells in the presence of polymer signals and how optical aberrations may affect these measurements. We show that Raman spectra of cells cultured on polymer substrates can be obtained using automatic subtraction of the polymer signals and demonstrate the capabilities of these methods in two important applications: tissue engineering and in vitro toxicology screening of drugs. Apart from their scientific and technological importance, these applications are examples of the two most common measurement configurations: (1) cells cultured on an optically thick polymer substrate measured using an immersion/dipping objective; and (2) cells cultured on a transparent polymer substrate and measured using an inverted optical microscope. In these examples, we show that Raman hyperspectral data sets with sufficient quality can be successfully acquired to map the distribution of common biomolecules in cells, such as nucleic acids, proteins, and lipids, as well as detecting the early stages of apoptosis. We also discuss strategies for further improvements that could expand the application of Raman hyperspectral imaging on polymer substrates even further in biomedical sciences and engineering.

Label-Free Raman Hyperspectral Imaging of Single Cells Cultured on Polymer Substrates

PubMed Central

Sicilia, Giovanna; Shipp, Dustin W.; Marlow, Maria; Notingher, Ioan

2017-01-01

While Raman hyperspectral imaging has been widely used for label-free mapping of biomolecules in cells, these measurements require the cells to be cultured on weakly Raman scattering substrates. However, many applications in biological sciences and engineering require the cells to be cultured on polymer substrates that often generate large Raman scattering signals. Here, we discuss the theoretical limits of the signal-to-noise ratio in the Raman spectra of cells in the presence of polymer signals and how optical aberrations may affect these measurements. We show that Raman spectra of cells cultured on polymer substrates can be obtained using automatic subtraction of the polymer signals and demonstrate the capabilities of these methods in two important applications: tissue engineering and in vitro toxicology screening of drugs. Apart from their scientific and technological importance, these applications are examples of the two most common measurement configurations: (1) cells cultured on an optically thick polymer substrate measured using an immersion/dipping objective; and (2) cells cultured on a transparent polymer substrate and measured using an inverted optical microscope. In these examples, we show that Raman hyperspectral data sets with sufficient quality can be successfully acquired to map the distribution of common biomolecules in cells, such as nucleic acids, proteins, and lipids, as well as detecting the early stages of apoptosis. We also discuss strategies for further improvements that could expand the application of Raman hyperspectral imaging on polymer substrates even further in biomedical sciences and engineering. PMID:28828895

Meta!Blast computer game: a pipeline from science to 3D art to education

NASA Astrophysics Data System (ADS)

Schneller, William; Campbell, P. J.; Bassham, Diane; Wurtele, Eve Syrkin

2012-03-01

Meta!Blast (http://www.metablast.org) is designed to address the challenges students often encounter in understanding cell and metabolic biology. Developed by faculty and students in biology, biochemistry, computer science, game design, pedagogy, art and story, Meta!Blast is being created using Maya (http://usa.autodesk.com/maya/) and the Unity 3D (http://unity3d.com/) game engine, for Macs and PCs in classrooms; it has also been exhibited in an immersive environment. Here, we describe the pipeline from protein structural data and holographic information to art to the threedimensional (3D) environment to the game engine, by which we provide a publicly-available interactive 3D cellular world that mimics a photosynthetic plant cell.

Natural Polymer-Cell Bioconstructs for Bone Tissue Engineering.

PubMed

Titorencu, Irina; Albu, Madalina Georgiana; Nemecz, Miruna; Jinga, Victor V

2017-01-01

The major goal of bone tissue engineering is to develop bioconstructs which substitute the functionality of damaged natural bone structures as much as possible if critical-sized defects occur. Scaffolds that mimic the structure and composition of bone tissue and cells play a pivotal role in bone tissue engineering applications. First, composition, properties and in vivo synthesis of bone tissue are presented for the understanding of bone formation. Second, potential sources of osteoprogenitor cells have been investigated for their capacity to induce bone repair and regeneration. Third, taking into account that the main property to qualify one scaffold as a future bioconstruct for bone tissue engineering is the biocompatibility, the assessments which prove it are reviewed in this paper. Forth, various types of natural polymer- based scaffolds consisting in proteins, polysaccharides, minerals, growth factors etc, are discussed, and interaction between scaffolds and cells which proved bone tissue engineering concept are highlighted. Finally, the future perspectives of natural polymer-based scaffolds for bone tissue engineering are considered. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Three-Dimensional Printing of Human Skeletal Muscle Cells: An Interdisciplinary Approach for Studying Biological Systems

ERIC Educational Resources Information Center

Bagley, James R.; Galpin, Andrew J.

2015-01-01

Interdisciplinary exploration is vital to education in the 21st century. This manuscript outlines an innovative laboratory-based teaching method that combines elements of biochemistry/molecular biology, kinesiology/health science, computer science, and manufacturing engineering to give students the ability to better conceptualize complex…

A bird's-eye view of cell therapy and tissue engineering for cardiac regeneration.

PubMed

Soler-Botija, Carolina; Bagó, Juli R; Bayes-Genis, Antoni

2012-04-01

Complete recovery of ischemic cardiac muscle after myocardial infarction is still an unresolved concern. In recent years, intensive research efforts have focused on mimicking the physical and biological properties of myocardium for cardiac repair. Here we show how heart regeneration approaches have evolved from cell therapy to refined tissue engineering. Despite progressive improvements, the best cell type and delivery strategy are not well established. Our group has identified a new population of cardiac adipose tissue-derived progenitor cells with inherent cardiac and angiogenic potential that is a promising candidate for cell therapy to restore ischemic myocardium. We also describe results from three strategies for cell delivery into a murine model of myocardial infarction: intramyocardial injection, implantation of a fibrin patch loaded with cells, and an engineered bioimplant (a combination of chemically designed scaffold, peptide hydrogel, and cells); dual-labeling noninvasive bioluminescence imaging enables in vivo monitoring of cardiac-specific markers and cell survival. © 2012 New York Academy of Sciences.

Engineering excellence in breakthrough biomedical technologies: bioengineering at the University of California, Riverside.

PubMed

Schultz, Jane S; Rodgers, V G J

2012-07-01

The Department of Bioengineering at the University of California, Riverside (UCR), was established in 2006 and is the youngest department in the Bourns College of Engineering. It is an interdisciplinary research engine that builds strength from highly recognized experts in biochemistry, biophysics, biology, and engineering, focusing on common critical themes. The range of faculty research interests is notable for its diversity, from the basic cell biology through cell function to the physiology of the whole organism, each directed at breakthroughs in biomedical devices for measurement and therapy. The department forges future leaders in bioengineering, mirroring the field in being energetic, interdisciplinary, and fast moving at the frontiers of biomedical discoveries. Our educational programs combine a solid foundation in bio logical sciences and engineering, diverse communication skills, and training in the most advanced quantitative bioengineering research. Bioengineering at UCR also includes the Bioengineering Interdepartmental Graduate (BIG) program. With its slogan Start-Grow-Be-BIG, it is already recognized for its many accomplishments, including being third in the nation in 2011 for bioengineering students receiving National Science Foundation graduate research fellowships as well as being one of the most ethnically inclusive programs in the nation.

Vital roles of stem cells and biomaterials in skin tissue engineering

PubMed Central

Mohd Hilmi, Abu Bakar; Halim, Ahmad Sukari

2015-01-01

Tissue engineering essentially refers to technology for growing new human tissue and is distinct from regenerative medicine. Currently, pieces of skin are already being fabricated for clinical use and many other tissue types may be fabricated in the future. Tissue engineering was first defined in 1987 by the United States National Science Foundation which critically discussed the future targets of bioengineering research and its consequences. The principles of tissue engineering are to initiate cell cultures in vitro, grow them on scaffolds in situ and transplant the composite into a recipient in vivo. From the beginning, scaffolds have been necessary in tissue engineering applications. Regardless, the latest technology has redirected established approaches by omitting scaffolds. Currently, scientists from diverse research institutes are engineering skin without scaffolds. Due to their advantageous properties, stem cells have robustly transformed the tissue engineering field as part of an engineered bilayered skin substitute that will later be discussed in detail. Additionally, utilizing biomaterials or skin replacement products in skin tissue engineering as strategy to successfully direct cell proliferation and differentiation as well as to optimize the safety of handling during grafting is beneficial. This approach has also led to the cells’ application in developing the novel skin substitute that will be briefly explained in this review. PMID:25815126

Review paper: critical issues in tissue engineering: biomaterials, cell sources, angiogenesis, and drug delivery systems.

PubMed

Naderi, Hojjat; Matin, Maryam M; Bahrami, Ahmad Reza

2011-11-01

Tissue engineering is a newly emerging biomedical technology, which aids and increases the repair and regeneration of deficient and injured tissues. It employs the principles from the fields of materials science, cell biology, transplantation, and engineering in an effort to treat or replace damaged tissues. Tissue engineering and development of complex tissues or organs, such as heart, muscle, kidney, liver, and lung, are still a distant milestone in twenty-first century. Generally, there are four main challenges in tissue engineering which need optimization. These include biomaterials, cell sources, vascularization of engineered tissues, and design of drug delivery systems. Biomaterials and cell sources should be specific for the engineering of each tissue or organ. On the other hand, angiogenesis is required not only for the treatment of a variety of ischemic conditions, but it is also a critical component of virtually all tissue-engineering strategies. Therefore, controlling the dose, location, and duration of releasing angiogenic factors via polymeric delivery systems, in order to ultimately better mimic the stem cell niche through scaffolds, will dictate the utility of a variety of biomaterials in tissue regeneration. This review focuses on the use of polymeric vehicles that are made of synthetic and/or natural biomaterials as scaffolds for three-dimensional cell cultures and for locally delivering the inductive growth factors in various formats to provide a method of controlled, localized delivery for the desired time frame and for vascularized tissue-engineering therapies.

Using self-assembled monolayers to pattern ECM proteins and cells on substrates.

PubMed

Ostuni, Emanuele; Whitesides, George M; Ingber, Donald E; Chen, Christopher S

2009-01-01

We present a method that uses microcontact printing of alkanethiols on gold to generate patterned substrates presenting "islands" of extracellular matrix (ECM) surrounded by nonadhesive regions such that single cells attach and spread only on the adhesive regions. We have used this micropatterning technology to demonstrate that mammalian cells can be switched between growth and apoptosis programs in the presence of saturating concentrations of growth factors by either promoting or preventing cell spreading (Science 276:1425-1428, 1997). From the perspective of fundamental cell biology, these results suggested that the local differentials in growth and viability that are critical for the formation of complex tissue patterns may be generated by local changes in cell-ECM interactions. In the context of cell culture technologies, such as bioreactors and cellular engineering applications, the regulation of cell function by cell shape indicates that the adhesive microenvironment around cells can be carefully optimized by patterning a substrate in addition to using soluble factors (Biotech. Prog. 14:356-363, 1998). Micropatterning technology is playing a central role both in our understanding how ECM and cell shape regulate cell physiology and in facilitating the development of cellular biosensor and tissue engineering applications (Science 264:696-698, 1994; J. Neurosci. Res. 13:213-20, 1985; Biotech. Bioeng. 43:792-800, 1994).

Scientific Aspects of Polymer Electrolyte Fuel Cell Durability and Degradation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borup, Rodney; Meyers, Jeremy; Pivovar, Bryan

Rod Borup is a Team Leader in the fuel cell program at Los Alamos National Lab in Los Alamos, New Mexico. He received his B.S.E. in Chemical Engineering from the University of Iowa in 1988 and his Ph.D. from the University of Washington in 1993. He has worked on fuel cell technology since 1994, working in the areas of hydrogen production and PEM fuel cell stack components. He has been awarded 12 U.S. patents, authored over 40 papers related to fuel cell technology, and presented over 50 oral papers at national meetings. His current main research area is related tomore » water transport in PEM fuel cells and PEM fuel cell durability. Recently, he was awarded the 2005 DOE Hydrogen Program R&D Award for the most significant R&D contribution of the year for his team's work in fuel cell durability and was the Principal Investigator for the 2004 Fuel Cell Seminar (San Antonio, TX, USA) Best Poster Award. Jeremy Meyers is an Assistant Professor of materials science and engineering and mechanical engineering at the University of Texas at Austin, where his research focuses on the development of electrochemical energy systems and materials. Prior to joining the faculty at Texas, Jeremy worked as manager of the advanced transportation technology group at UTC Power, where he was responsible for developing new system designs and components for automotive PEM fuel cell power plants. While at UTC Power, Jeremy led several customer development projects and a DOE-sponsored investigation into novel catalysts and membranes for PEM fuel cells. Jeremy has coauthored several papers on key mechanisms of fuel cell degradation and is a co-inventor of several patents. In 2006, Jeremy and several colleagues received the George Mead Medal, UTC's highest award for engineering achievement, and he served as the co-chair of the Gordon Research Conference on fuel cells. Jeremy received his Ph.D. in Chemical Engineering from the University of California at Berkeley and holds a Bachelor's Degree in Chemical Engineering from Stanford University. Bryan Pivovar received his B.S. in Chemical Engineering from the University of Wisconsin in 1994. He completed his Ph.D. in Chemical Engineering at the University of Minnesota in 2000 under the direction of Profs. Ed Cussler and Bill Smyrl, studying transport properties in fuel cell electrolytes. He continued working in the area of polymer electrolyte fuel cells at Los Alamos National Laboratory as a post-doc (2000-2001), as a technical staff member (2001-2005), and in his current position as a team leader (2005-present). In this time, Bryan's research has expanded to include further aspects of fuel cell operation, including electrodes, subfreezing effects, alternative polymers, hydroxide conductors, fuel cell interfaces, impurities, water transport, and high-temperature membranes. Bryan has served at various levels in national and international conferences and workshops, including organizing a DOE sponsored workshop on freezing effects in fuel cells and an ARO sponsored workshop on alkaline membrane fuel cells, and he was co-chair of the 2007 Gordon Research Conference on Fuel Cells. Minoru Inaba is a Professor at the Department of Molecular Science and Technology, Faculty of Engineering, Doshisha University, Japan. He received his B.Sc. from the Faculty of Engineering, Kyoto University, in 1984 and his M.Sc. in 1986 and his Dr. Eng. in 1995 from the Graduate School of Engineering, Kyoto University. He has worked on electrochemical energy conversion systems including fuel cells and lithium-ion batteries at Kyoto University (1992-2002) and at Doshisha University (2002-present). His primary research interest is the durability of polymer electrolyte fuel cells (PEFCs), in particular, membrane degradation, and he has been involved in NEDO R&D research projects on PEFC durability since 2001. He has authored over 140 technical papers and 30 review articles. Kenichiro Ota is a Professor of the Chemical Energy Laboratory at the Graduate School of Engineering, Yokohama National University, Japan. He received his B.S.E. in Applied Chemistry from the University of Tokyo in 1968 and his Ph.D. from the University of Tokyo in 1973. He has worked on hydrogen energy and fuel cells since 1974, working on materials science for fuel cells and water electrolysis. He has published more than 150 original papers, 70 review papers, and 50 scientific books. He is now the president of the Hydrogen Energy Systems Society of Japan, the chairman of the Fuel Cell Research Group of the Electrochemical Society of Japan, and the chairman of the National Committee for the Standardization of the Stationary Fuel Cells. ABSTRACT TRUNCATED« less

Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part I: from three-dimensional cell growth to biomimetics of in vivo development.

PubMed

Lenas, Petros; Moos, Malcolm; Luyten, Frank P

2009-12-01

Recent advances in developmental biology, systems biology, and network science are converging to poise the heretofore largely empirical field of tissue engineering on the brink of a metamorphosis into a rigorous discipline based on universally accepted engineering principles of quality by design. Failure of more simplistic approaches to the manufacture of cell-based therapies has led to increasing appreciation of the need to imitate, at least to some degree, natural mechanisms that control cell fate and differentiation. The identification of many of these mechanisms, which in general are based on cell signaling pathways, is an important step in this direction. Some well-accepted empirical concepts of developmental biology, such as path-dependence, robustness, modularity, and semiautonomy of intermediate tissue forms, that appear sequentially during tissue development are starting to be incorporated in process design.

Tissue engineering and regenerative medicine: concepts for clinical application.

PubMed

Atala, Anthony

2004-01-01

Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly given the aging population. Scientists in the field of regenerative medicine and tissue engineering apply the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. This paper reviews recent advances that have occurred in regenerative medicine and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

Promoting STEM to Young Students by Renewable Energy Applications

ERIC Educational Resources Information Center

Pecen, Recayi; Humston, Jill L.; Yildiz, Faruk

2012-01-01

The Math-Science-Engineering Technology in Iowa on Applied Renewable Energy Areas (MSETI-AREA) projects are aimed at providing area school teachers with an applied mathematics and science curriculum package based on photovoltaic (PV) power, wind power, human power and hydrogen fuel-cell fundamentals. The MSETI-AREA project has established a…

Restoration of neurological functions by neuroprosthetic technologies: future prospects and trends towards micro-, nano-, and biohybrid systems.

PubMed

Stieglitz, T

2007-01-01

Today applications of neural prostheses that successfully help patients to increase their activities of daily living and participate in social life again are quite simple implants that yield definite tissue response and are well recognized as foreign body. Latest developments in genetic engineering, nanotechnologies and materials sciences have paved the way to new scenarios towards highly complex systems to interface the human nervous system. Combinations of neural cells with microimplants promise stable biohybrid interfaces. Nanotechnology opens the door to macromolecular landscapes on implants that mimic the biologic topology and surface interaction of biologic cells. Computer sciences dream of technical cognitive systems that act and react due to knowledge-based conclusion mechanisms to a changing or adaptive environment. Different sciences start to interact and discuss the synergies when methods and paradigms from biology, computer sciences and engineering, neurosciences, psychology will be combined. They envision the era of "converging technologies" to completely change the understanding of science and postulate a new vision of humans. In this chapter, these research lines will be discussed on some examples as well as the societal implications and ethical questions that arise from these new opportunities.

Biological mechanisms beyond network analysis via mathematical modeling. Comment on "Network science of biological systems at different scales: A review" by Marko Gosak et al.

NASA Astrophysics Data System (ADS)

Pedersen, Morten Gram

2018-03-01

Methods from network theory are increasingly used in research spanning from engineering and computer science to psychology and the social sciences. In this issue, Gosak et al. [1] provide a thorough review of network science applications to biological systems ranging from the subcellular world via neuroscience to ecosystems, with special attention to the insulin-secreting beta-cells in pancreatic islets.

SIGNALING MECHANISMS IN HUMAN AIRWAY EPITHELIAL CELLS EXPOSED TO CARBON ULTRAFINE PARTICLES

EPA Science Inventory

SIGNALING MECHANISMS IN HUMAN AIRWAY EPITHELIAL CELLS EXPOSED TO CARBON ULTRAFINE PARTICLES
Y.M. Kim, A.G. Lenz, R. Silbajoris, I. Jaspers and J.M. Samet. Department of Environmental Sciences and Engineering and Center for Environmental Medicine, University of North Carolina, ...

Tissue engineering: current strategies and future directions.

PubMed

Olson, Jennifer L; Atala, Anthony; Yoo, James J

2011-04-01

Novel therapies resulting from regenerative medicine and tissue engineering technology may offer new hope for patients with injuries, end-stage organ failure, or other clinical issues. Currently, patients with diseased and injured organs are often treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and as the number of new cases of organ failure increases. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that can restore and maintain normal function in diseased and injured tissues. In addition, the stem cell field is a rapidly advancing part of regenerative medicine, and new discoveries in this field create new options for this type of therapy. For example, new types of stem cells, such as amniotic fluid and placental stem cells that can circumvent the ethical issues associated with embryonic stem cells, have been discovered. The process of therapeutic cloning and the creation of induced pluripotent cells provide still other potential sources of stem cells for cell-based tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous, adult cells have already entered the clinical setting, indicating that regenerative medicine holds much promise for the future.

Chimeric antigen receptors: driving immunology towards synthetic biology

PubMed Central

Sadelain, Michel

2017-01-01

The advent of second generation CARs and the CD19 paradigm have ushered a new therapeutic modality in oncology. In contrast to earlier forms of adoptive cell therapy, which were based on the isolation and expansion of naturally occurring T cells, CAR therapy is based on the design and manufacture of engineered T cells with optimized properties. A new armamentarium, comprising not only CARs but also chimeric costimulatory receptors, chimeric cytokine receptors, inhibitory receptors and synthetic Notch receptors, expressed in naïve, central memory or stem cell-like memory T cells, is being developed for clinical use in a wide range of cancers. Immunological principles are thus finding a new purpose thanks to advances in genetic engineering, synthetic biology and cell manufacturing sciences. PMID:27372731

Tissue Engineering of Urinary Bladder and Urethra: Advances from Bench to Patients

PubMed Central

Bouhout, Sara; Chabaud, Stéphane; Bolduc, Stéphane

2013-01-01

Urinary tract is subjected to many varieties of pathologies since birth including congenital anomalies, trauma, inflammatory lesions, and malignancy. These diseases necessitate the replacement of involved organs and tissues. Shortage of organ donation, problems of immunosuppression, and complications associated with the use of nonnative tissues have urged clinicians and scientists to investigate new therapies, namely, tissue engineering. Tissue engineering follows principles of cell transplantation, materials science, and engineering. Epithelial and muscle cells can be harvested and used for reconstruction of the engineered grafts. These cells must be delivered in a well-organized and differentiated condition because water-seal epithelium and well-oriented muscle layer are needed for proper function of the substitute tissues. Synthetic or natural scaffolds have been used for engineering lower urinary tract. Harnessing autologous cells to produce their own matrix and form scaffolds is a new strategy for engineering bladder and urethra. This self-assembly technique avoids the biosafety and immunological reactions related to the use of biodegradable scaffolds. Autologous equivalents have already been produced for pigs (bladder) and human (urethra and bladder). The purpose of this paper is to present a review for the existing methods of engineering bladder and urethra and to point toward perspectives for their replacement. PMID:24453796

Multiscale assembly for tissue engineering and regenerative medicine

PubMed Central

Inci, Fatih; Tasoglu, Savas; Erkmen, Burcu; Demirci, Utkan

2015-01-01

Our understanding of cell biology and its integration with materials science has led to technological innovations in the bioengineering of tissue-mimicking grafts that can be utilized in clinical and pharmaceutical applications. Bio-engineering of native-like multiscale building blocks provides refined control over the cellular microenvironment, thus enabling functional tissues. In this review, we focus on assembling building blocks from the biomolecular level to the millimeter scale. We also provide an overview of techniques for assembling molecules, cells, spheroids, and microgels and achieving bottom-up tissue engineering. Additionally, we discuss driving mechanisms for self- and guided assembly to create micro-to-macro scale tissue structures. PMID:25796488

Engineering-derived approaches for iPSC preparation, expansion, differentiation and applications.

PubMed

Li, Yang; Li, Ling; Chen, Zhi-Nan; Gao, Ge; Yao, Rui; Sun, Wei

2017-07-31

Remarkable achievements have been made since induced pluripotent stem cells (iPSCs) were first introduced in 2006. Compared with non-pluripotent stem cells, iPSC research faces several additional complexities, such as the choice of extracellular matrix proteins, growth and differentiation factors, as well as technical challenges related to self-renewal and directed differentiation. Overcoming these challenges requires the integration of knowledge and technologies from multiple fields including cell biology, biomaterial science, engineering, physics and medicine. Here, engineering-derived iPSC approaches are reviewed according to three aspects of iPSC studies: preparation, expansion, differentiation and applications. Engineering strategies, such as 3D systems establishment, cell-matrix mechanics and the regulation of biophysical and biochemical cues, together with engineering techniques, such as 3D scaffolds, cell microspheres and bioreactors, have been applied to iPSC studies and have generated insightful results and even mini-organs such as retinas, livers and intestines. Specific results are given to demonstrate how these approaches impact iPSC behavior, and related mechanisms are discussed. In addition, cell printing technologies are presented as an advanced engineering-derived approach since they have been applied in both iPSC studies and the construction of diverse tissues and organs. Further development and possible innovations of cell printing technologies are presented in terms of creating complex and functional iPSC-derived living tissues and organs.

Systems biology: the case for a systems science approach to diabetes.

PubMed

Petrasek, Danny

2008-01-01

The unprecedented accumulation of biological data in recent decades has underscored the need to organize and integrate the massive collection of information. In addition, there is rising agreement among biologists that a complete understanding of a single cell will not lead directly to a complete understanding of a system of cells. The success of a systems science approach in engineering and physics may be of great value in the evolution of biological science. This article reviews some examples that suggest the importance of a systems biology approach and, in addition, advance one specific systems science principle, the conservation of uncertainty, which may give insight into the emergent behavior of numerous biological and physiological phenomena.

Tissue engineering, stem cells and cloning: current concepts and changing trends.

PubMed

Atala, Anthony

2005-07-01

Organ damage or loss can occur from congenital disorders, cancer, trauma, infection, inflammation, iatrogenic injuries or other conditions and often necessitates reconstruction or replacement. Replacement may take the form of organ transplant. At present, there is a severe shortage of donor organs that is worsening with the aging of the population. Tissue engineering follows the principles of cell transplantation, materials science and engineering towards the development of biological substitutes that can restore and maintain normal tissue function. Therapeutic cloning involves the introduction of a nucleus from a donor cell into an enucleated oocyte to generate embryonic stem cell lines whose genetic material is identical to that of its source. These autologous stem cells have the potential to become almost any type of cell in the adult body, and thus would be useful in tissue and organ replacement applications. This paper reviews recent advances in stem cell research and regenerative medicine, and describes the clinical applications of these technologies as novel therapies for tissue or organ loss.

Prospect of Stem Cells in Bone Tissue Engineering: A Review

PubMed Central

Yousefi, Azizeh-Mitra; James, Paul F.; Akbarzadeh, Rosa; Subramanian, Aswati; Flavin, Conor; Oudadesse, Hassane

2016-01-01

Mesenchymal stem cells (MSCs) have been the subject of many studies in recent years, ranging from basic science that looks into MSCs properties to studies that aim for developing bioengineered tissues and organs. Adult bone marrow-derived mesenchymal stem cells (BM-MSCs) have been the focus of most studies due to the inherent potential of these cells to differentiate into various cell types. Although, the discovery of induced pluripotent stem cells (iPSCs) represents a paradigm shift in our understanding of cellular differentiation. These cells are another attractive stem cell source because of their ability to be reprogramed, allowing the generation of multiple cell types from a single cell. This paper briefly covers various types of stem cell sources that have been used for tissue engineering applications, with a focus on bone regeneration. Then, an overview of some recent studies making use of MSC-seeded 3D scaffold systems for bone tissue engineering has been presented. The emphasis has been placed on the reported scaffold properties that tend to improve MSCs adhesion, proliferation, and osteogenic differentiation outcomes. PMID:26880976

A Middleware Platform for Providing Mobile and Embedded Computing Instruction to Software Engineering Students

ERIC Educational Resources Information Center

Mattmann, C. A.; Medvidovic, N.; Malek, S.; Edwards, G.; Banerjee, S.

2012-01-01

As embedded software systems have grown in number, complexity, and importance in the modern world, a corresponding need to teach computer science students how to effectively engineer such systems has arisen. Embedded software systems, such as those that control cell phones, aircraft, and medical equipment, are subject to requirements and…

Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries.

PubMed

Hong, Kuk-Ki; Nielsen, Jens

2012-08-01

Metabolic engineering is the enabling science of development of efficient cell factories for the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial fermentations. The yeast Saccharomyces cerevisiae is a key cell factory already used for the production of a wide range of industrial products, and here we review ongoing work, particularly in industry, on using this organism for the production of butanol, which can be used as biofuel, and isoprenoids, which can find a wide range of applications including as pharmaceuticals and as biodiesel. We also look into how engineering of yeast can lead to improved uptake of sugars that are present in biomass hydrolyzates, and hereby allow for utilization of biomass as feedstock in the production of fuels and chemicals employing S. cerevisiae. Finally, we discuss the perspectives of how technologies from systems biology and synthetic biology can be used to advance metabolic engineering of yeast.

Engineering organs.

PubMed

Atala, Anthony

2009-10-01

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new avenues for this type of therapy. For example, therapeutic cloning and cellular reprogramming may one day provide a potentially limitless source of cells for tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future.

Teaching Cell and Molecular Biology for Gender Equity

ERIC Educational Resources Information Center

Sible, Jill C.; Wilhelm, Dayna E.; Lederman, Muriel

2006-01-01

Science, technology, engineering, and math (STEM) fields, including cell biology, are characterized by the "leaky pipeline" syndrome in which, over time, women leave the discipline. The pipeline itself and the pond into which it empties may not be neutral. Explicating invisible norms, attitudes, and practices by integrating social…

2015: Signaling Breakthroughs of the Year.

PubMed

Adler, Elizabeth M

2016-01-05

This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells. Copyright © 2016, American Association for the Advancement of Science.

3D Printing of Personalized Organs and Tissues

NASA Astrophysics Data System (ADS)

Ye, Kaiming

2015-03-01

Authors: Kaiming Ye and Sha Jin, Department of Biomedical Engineering, Watson School of Engineering and Applied Science, Binghamton University, State University of New York, Binghamton, NY 13902-6000 Abstract: Creation of highly organized multicellular constructs, including tissues and organs or organoids, will revolutionize tissue engineering and regenerative medicine. The development of these technologies will enable the production of individualized organs or tissues for patient-tailored organ transplantation or cell-based therapy. For instance, a patient with damaged myocardial tissues due to an ischemic event can receive a myocardial transplant generated using the patient's own induced pluripotent stem cells (iPSCs). Likewise, a type-1 diabetic patient can be treated with lab-generated islets to restore his or her physiological insulin secretion capability. These lab-produced, high order tissues or organs can also serve as disease models for pathophysiological study and drug screening. The remarkable advances in stem cell biology, tissue engineering, microfabrication, and materials science in the last decade suggest the feasibility of generating these tissues and organoids in the laboratory. Nevertheless, major challenges still exist. One of the critical challenges that we still face today is the difficulty in constructing or fabricating multicellular assemblies that recapitulate in vivo microenvironments essential for controlling cell proliferation, migration, differentiation, maturation and assembly into a biologically functional tissue or organoid structure. These challenges can be addressed through developing 3D organ and tissue printing which enables organizing and assembling cells into desired tissue and organ structures. We have shown that human pluripotent stem cells differentiated in 3D environments are mature and possess high degree of biological function necessary for them to function in vivo.

Concise review: carbon nanotechnology: perspectives in stem cell research.

PubMed

Pryzhkova, Marina V

2013-05-01

Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering.

Evaluating Learning and Attitudes on Tissue Engineering: A Study of Children Viewing Animated Digital Dome Shows Detailing the Biomedicine of Tissue Engineering

PubMed Central

Wilson, Anna C.; Gonzalez, Laura L.

2012-01-01

Informal science education creates opportunities for the general public to learn about complex health and science topics. Tissue engineering is a fast-growing field of medical science that combines advanced chemistries to create synthetic scaffolds, stem cells, and growth factors that individually or in combination can support the bodies own healing powers to remedy a range of maladies. Health literacy about this topic is increasingly important as our population ages and as treatments become more technologically advanced. We are using a science center planetarium as a projection space to engage and educate the public about the science and biomedical research that supports tissue engineering. The purpose of this study was to test the effectiveness of the films that we have produced for part of the science center planetarium demographic, specifically children ranging in age from 7 to 16 years. A two-group pre- and post-test design was used to compare children's learning and attitude changes in response to the two versions of the film. One version uses traditional voice-over narration; the other version uses dialog between two animated characters. The results of this study indicate that children demonstrated increases in knowledge of the topic with either film format, but preferred the animated character version. The percentage change in children's scores on the knowledge questions given before and after viewing the show exhibited an improvement from 23% correct to 61% correct on average. In addition, many of the things that the children reported liking were part of the design process of the art–science collaboration. Other results indicated that before viewing the shows 77% of the children had not even heard about tissue engineering and only 17% indicated that they were very interested in it, whereas after viewing the shows, 95% indicated that tissue engineering was a good idea. We also find that after viewing the show, 71% of the children reported that the show made them think, 75% enjoyed it, and 89% felt that they learned something. We discuss the potential impact the films might have on public knowledge, health literacy, and attitudes toward the science of tissue engineering. PMID:21943030

Evaluating learning and attitudes on tissue engineering: a study of children viewing animated digital dome shows detailing the biomedicine of tissue engineering.

PubMed

Wilson, Anna C; Gonzalez, Laura L; Pollock, John A

2012-03-01

Informal science education creates opportunities for the general public to learn about complex health and science topics. Tissue engineering is a fast-growing field of medical science that combines advanced chemistries to create synthetic scaffolds, stem cells, and growth factors that individually or in combination can support the bodies own healing powers to remedy a range of maladies. Health literacy about this topic is increasingly important as our population ages and as treatments become more technologically advanced. We are using a science center planetarium as a projection space to engage and educate the public about the science and biomedical research that supports tissue engineering. The purpose of this study was to test the effectiveness of the films that we have produced for part of the science center planetarium demographic, specifically children ranging in age from 7 to 16 years. A two-group pre- and post-test design was used to compare children's learning and attitude changes in response to the two versions of the film. One version uses traditional voice-over narration; the other version uses dialog between two animated characters. The results of this study indicate that children demonstrated increases in knowledge of the topic with either film format, but preferred the animated character version. The percentage change in children's scores on the knowledge questions given before and after viewing the show exhibited an improvement from 23% correct to 61% correct on average. In addition, many of the things that the children reported liking were part of the design process of the art-science collaboration. Other results indicated that before viewing the shows 77% of the children had not even heard about tissue engineering and only 17% indicated that they were very interested in it, whereas after viewing the shows, 95% indicated that tissue engineering was a good idea. We also find that after viewing the show, 71% of the children reported that the show made them think, 75% enjoyed it, and 89% felt that they learned something. We discuss the potential impact the films might have on public knowledge, health literacy, and attitudes toward the science of tissue engineering.

Rheology of Soft Materials

NASA Astrophysics Data System (ADS)

Chen, Daniel T. N.; Wen, Qi; Janmey, Paul A.; Crocker, John C.; Yodh, Arjun G.

2010-04-01

Research on soft materials, including colloidal suspensions, glasses, pastes, emulsions, foams, polymer networks, liquid crystals, granular materials, and cells, has captured the interest of scientists and engineers in fields ranging from physics and chemical engineering to materials science and cell biology. Recent advances in rheological methods to probe mechanical responses of these complex media have been instrumental for producing new understanding of soft matter and for generating novel technological applications. This review surveys these technical developments and current work in the field, with partial aim to illustrate open questions for future research.

Cell-based therapeutics: the next pillar of medicine.

PubMed

Fischbach, Michael A; Bluestone, Jeffrey A; Lim, Wendell A

2013-04-03

Two decades ago, the pharmaceutical industry-long dominated by small-molecule drugs-was revolutionized by the the advent of biologics. Today, biomedicine sits on the cusp of a new revolution: the use of microbial and human cells as versatile therapeutic engines. Here, we discuss the promise of this "third pillar" of therapeutics in the context of current scientific, regulatory, economic, and perceptual challenges. History suggests that the advent of cellular medicines will require the development of a foundational cellular engineering science that provides a systematic framework for safely and predictably altering and regulating cellular behaviors.

Chronic B-Cell Leukemias and Agent Orange

MedlinePlus

... of Medicine) of the National Academy of Sciences, Engineering, and Medicine focused on chronic lymphocytic leukemia in ... VA Plans, Budget, & Performance VA Claims Representation RESOURCES Careers at VA Employment Center Returning Service Members Vocational ...

Reducing Our Carbon Footprint: Converting Plants to Fuel (LBNL Science at the Theater)

ScienceCinema

Somerville, Chris [Univ. of California, Berkeley, CA (United States)

2018-05-23

Berkeley Lab's Chris Somerville is a leading authority on the structure and function of plant cell walls, which comprise most of the body mass of higher plants. He views the knowledge of cell wall structure and function as furthering the development of plants with improved usefulness: these plants are strong potential sources of renewable materials and biofuel feedstocks. His scientific expertise defines an ideal match of his interest - in the development of cellulosic and other solar-to-fuel science - with his recent appointment as Director of the Energy Biosciences Institute (EBI). With colleagues in biology, physical sciences, engineering, and environmental and the social sciences, he now leads the EBI multidisciplinary teams' research efforts to develop next-generation, carbon-neutral transportation fuels.

Broadening Participation of Women and Underrepresented Minorities in STEM through a Hybrid Online Transfer Program

ERIC Educational Resources Information Center

Drew, Jennifer C.; Galindo-Gonzalez, Sebastian; Ardissone, Alexandria N.; Triplett, Eric W.

2016-01-01

The Microbiology and Cell Science (MCS) Department at the University of Florida (UF) developed a new model of a 2 + 2 program that uses a hybrid online approach to bring its science, technology, engineering, and mathematics (STEM) curriculum to students. In this paradigm, 2-year graduates transfer as online students into the Distance Education in…

Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering.

PubMed

Moyer, Tyler C; Holland, Andrew J

2015-01-01

The ability to rapidly and specifically modify the genome of mammalian cells has been a long-term goal of biomedical researchers. Recently, the clustered, regularly interspaced, short palindromic repeats (CRISPR)/Cas9 system from bacteria has been exploited for genome engineering in human cells. The CRISPR system directs the RNA-guided Cas9 nuclease to a specific genomic locus to induce a DNA double-strand break that may be subsequently repaired by homology-directed repair using an exogenous DNA repair template. Here we describe a protocol using CRISPR/Cas9 to achieve bi-allelic insertion of a point mutation in human cells. Using this method, homozygous clonal cell lines can be constructed in 5-6 weeks. This method can also be adapted to insert larger DNA elements, such as fluorescent proteins and degrons, at defined genomic locations. CRISPR/Cas9 genome engineering offers exciting applications in both basic science and translational research. Copyright © 2015 Elsevier Inc. All rights reserved.

MESC Payload Setup

NASA Image and Video Library

2017-02-21

iss050e052142 (Feb. 21, 2017) --- Expedition 50 Flight Engineer Peggy Whitson sets up a microscope in support of the Microgravity Expanded Stem Cells payload outside the Microgravity Science Glovebox housed inside the U.S. Destiny laboratory module.

United States Air Force Graduate Student Summer Support Program 1986. Program Technical Report. Volume 1

DTIC Science & Technology

1986-12-01

Oxidant Damage Mediates Variant Red Cell Resistance to Malaria. Nature. 280 (1979) p. 245-47. 14. Geary, Timothy G. and James B. Jensen. Effects of...for research in the physical sciences, engineering, life sciences, business, and administrative sciences. The program has been effective in providing...Researcher Volume I 1 The Effects of Fourier Limited Targets Susan M. Abrams Upon Peripheral Perception 2 Studies of the Dimenslonality of William H

Stem cell bioprinting for applications in regenerative medicine.

PubMed

Tricomi, Brad J; Dias, Andrew D; Corr, David T

2016-11-01

Many regenerative medicine applications seek to harness the biologic power of stem cells in architecturally complex scaffolds or microenvironments. Traditional tissue engineering methods cannot create such intricate structures, nor can they precisely control cellular position or spatial distribution. These limitations have spurred advances in the field of bioprinting, aimed to satisfy these structural and compositional demands. Bioprinting can be defined as the programmed deposition of cells or other biologics, often with accompanying biomaterials. In this concise review, we focus on recent advances in stem cell bioprinting, including performance, utility, and applications in regenerative medicine. More specifically, this review explores the capability of bioprinting to direct stem cell fate, engineer tissue(s), and create functional vascular networks. Furthermore, the unique challenges and concerns related to bioprinting living stem cells, such as viability and maintaining multi- or pluripotency, are discussed. The regenerative capacity of stem cells, when combined with the structural/compositional control afforded by bioprinting, provides a unique and powerful tool to address the complex demands of tissue engineering and regenerative medicine applications. © 2016 New York Academy of Sciences.

Photovoltaic Science and Engineering Conference in Japan, 2nd, Tokyo, Japan, December 2-4, 1980, Proceedings

NASA Astrophysics Data System (ADS)

The state-of-the-art in amorphous solar cells is reviewed in terms of polycrystalline silicon solar cells, single crystal silicon solar cells, and methods of characterizing solar cells, including dielectric liquid immersion to increase cell efficiency. Compound semiconductor solar cells are explored, and new structures and advanced solar cell materials are discussed. Film deposition techniques for fabricating amorphous solar cells are presented, and the characterization, in addition to the physics and the performance, of amorphous solar cells are examined.

Concise Review: Carbon Nanotechnology: Perspectives in Stem Cell Research

PubMed Central

2013-01-01

Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering. PMID:23572053

Biological Effects of Spirulina (Arthrospira) Biopolymers and Biomass in the Development of Nanostructured Scaffolds

PubMed Central

de Morais, Michele Greque; Vaz, Bruna da Silva; de Morais, Etiele Greque; Costa, Jorge Alberto Vieira

2014-01-01

Spirulina is produced from pure cultures of the photosynthetic prokaryotic cyanobacteria Arthrospira. For many years research centers throughout the world have studied its application in various scientific fields, especially in foods and medicine. The biomass produced from Spirulina cultivation contains a variety of biocompounds, including biopeptides, biopolymers, carbohydrates, essential fatty acids, minerals, oligoelements, and sterols. Some of these compounds are bioactive and have anti-inflammatory, antibacterial, antioxidant, and antifungal properties. These compounds can be used in tissue engineering, the interdisciplinary field that combines techniques from cell science, engineering, and materials science and which has grown in importance over the past few decades. Spirulina biomass can be used to produce polyhydroxyalkanoates (PHAs), biopolymers that can substitute synthetic polymers in the construction of engineered extracellular matrices (scaffolds) for use in tissue cultures or bioactive molecule construction. This review describes the development of nanostructured scaffolds based on biopolymers extracted from microalgae and biomass from Spirulina production. These scaffolds have the potential to encourage cell growth while reducing the risk of organ or tissue rejection. PMID:25157367

Development of 3D in Vitro Technology for Medical Applications

PubMed Central

Ou, Keng-Liang; Hosseinkhani, Hossein

2014-01-01

In the past few years, biomaterials technologies together with significant efforts on developing biology have revolutionized the process of engineered materials. Three dimensional (3D) in vitro technology aims to develop set of tools that are simple, inexpensive, portable and robust that could be commercialized and used in various fields of biomedical sciences such as drug discovery, diagnostic tools, and therapeutic approaches in regenerative medicine. The proliferation of cells in the 3D scaffold needs an oxygen and nutrition supply. 3D scaffold materials should provide such an environment for cells living in close proximity. 3D scaffolds that are able to regenerate or restore tissue and/or organs have begun to revolutionize medicine and biomedical science. Scaffolds have been used to support and promote the regeneration of tissues. Different processing techniques have been developed to design and fabricate three dimensional scaffolds for tissue engineering implants. Throughout the chapters we discuss in this review, we inform the reader about the potential applications of different 3D in vitro systems that can be applied for fabricating a wider range of novel biomaterials for use in tissue engineering. PMID:25299693

Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part II: from genes to networks: tissue engineering from the viewpoint of systems biology and network science.

PubMed

Lenas, Petros; Moos, Malcolm; Luyten, Frank P

2009-12-01

The field of tissue engineering is moving toward a new concept of "in vitro biomimetics of in vivo tissue development." In Part I of this series, we proposed a theoretical framework integrating the concepts of developmental biology with those of process design to provide the rules for the design of biomimetic processes. We named this methodology "developmental engineering" to emphasize that it is not the tissue but the process of in vitro tissue development that has to be engineered. To formulate the process design rules in a rigorous way that will allow a computational design, we should refer to mathematical methods to model the biological process taking place in vitro. Tissue functions cannot be attributed to individual molecules but rather to complex interactions between the numerous components of a cell and interactions between cells in a tissue that form a network. For tissue engineering to advance to the level of a technologically driven discipline amenable to well-established principles of process engineering, a scientifically rigorous formulation is needed of the general design rules so that the behavior of networks of genes, proteins, or cells that govern the unfolding of developmental processes could be related to the design parameters. Now that sufficient experimental data exist to construct plausible mathematical models of many biological control circuits, explicit hypotheses can be evaluated using computational approaches to facilitate process design. Recent progress in systems biology has shown that the empirical concepts of developmental biology that we used in Part I to extract the rules of biomimetic process design can be expressed in rigorous mathematical terms. This allows the accurate characterization of manufacturing processes in tissue engineering as well as the properties of the artificial tissues themselves. In addition, network science has recently shown that the behavior of biological networks strongly depends on their topology and has developed the necessary concepts and methods to describe it, allowing therefore a deeper understanding of the behavior of networks during biomimetic processes. These advances thus open the door to a transition for tissue engineering from a substantially empirical endeavor to a technology-based discipline comparable to other branches of engineering.

Mammalian designer cells: Engineering principles and biomedical applications.

PubMed

Xie, Mingqi; Fussenegger, Martin

2015-07-01

Biotechnology is a widely interdisciplinary field focusing on the use of living cells or organisms to solve established problems in medicine, food production and agriculture. Synthetic biology, the science of engineering complex biological systems that do not exist in nature, continues to provide the biotechnology industry with tools, technologies and intellectual property leading to improved cellular performance. One key aspect of synthetic biology is the engineering of deliberately reprogrammed designer cells whose behavior can be controlled over time and space. This review discusses the most commonly used techniques to engineer mammalian designer cells; while control elements acting on the transcriptional and translational levels of target gene expression determine the kinetic and dynamic profiles, coupling them to a variety of extracellular stimuli permits their remote control with user-defined trigger signals. Designer mammalian cells with novel or improved biological functions not only directly improve the production efficiency during biopharmaceutical manufacturing but also open the door for cell-based treatment strategies in molecular and translational medicine. In the future, the rational combination of multiple sets of designer cells could permit the construction and regulation of higher-order systems with increased complexity, thereby enabling the molecular reprogramming of tissues, organisms or even populations with highest precision. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Somerville, Chris

Berkeley Lab's Chris Somerville is a leading authority on the structure and function of plant cell walls, which comprise most of the body mass of higher plants. He views the knowledge of cell wall structure and function as furthering the development of plants with improved usefulness: these plants are strong potential sources of renewable materials and biofuel feedstocks. His scientific expertise defines an ideal match of his interest - in the development of cellulosic and other solar-to-fuel science - with his recent appointment as Director of the Energy Biosciences Institute (EBI). With colleagues in biology, physical sciences, engineering, and environmentalmore » and the social sciences, he now leads the EBI multidisciplinary teams' research efforts to develop next-generation, carbon-neutral transportation fuels.« less

A Global Assessment of Stem Cell Engineering

PubMed Central

Loring, Jeanne F.; McDevitt, Todd C.; Palecek, Sean P.; Schaffer, David V.; Zandstra, Peter W.

2014-01-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic–industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms. PMID:24428577

A global assessment of stem cell engineering.

PubMed

Loring, Jeanne F; McDevitt, Todd C; Palecek, Sean P; Schaffer, David V; Zandstra, Peter W; Nerem, Robert M

2014-10-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic-industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms.

Regenerative dentistry: translating advancements in basic science research to the dental practice.

PubMed

Garcia-Godoy, Franklin; Murray, Peter

2010-01-01

Scientific advances in the creation of restorative biomaterials, in vitro cell culture technology, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. This review provides an assessment of how tissue engineering, stem cell, genetic transfer, biomaterial and growth factor therapies can be integrated into clinical dental therapies to restore and regenerate oral tissues. In parallel to the creation of a new field in general medicine called "regenerative medicine," we call this field "regenerative dentistry." While the problems of introducing regenerative therapies are substantial, the potential benefits to patients and the profession are equally ground-breaking. In this review, we outline a few areas of interest for the future of oral and dental medicine in which advancements in basic science have already been adapted to fit the goals of 21st century dentistry.

Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity.

PubMed

Baudoin, Régis; Corlu, Anne; Griscom, Laurent; Legallais, Cécile; Leclerc, Eric

2007-06-01

Current developments in the technological fields of liver tissue engineering, bioengineering, biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent new tools called "cell biochips" for in vitro toxicology. The purpose of "cell biochips" is to mimic organ tissues in vitro in order to partially reduce the amount of in vivo testing. These "cell biochips" consist of microchambers containing engineered tissue and living cell cultures interconnected by a microfluidic network, which allows the control of microfluidic flows for dynamic cultures, by continuous feeding of nutrients to cultured cells and waste removal. Cell biochips also allow the control of physiological contact times of diluted molecules with the tissues and cells, for rapid testing of sample preparations or specific addressing. Cell biochips can be situated between in vitro and in vivo testing. These types of systems can enhance functionality of cells by mimicking the tissue architecture complexities when compared to in vitro analysis but at the same time present a more rapid and simple process when compared to in vivo testing procedures. In this paper, we first introduce the concepts of microfluidic and biochip systems based on recent progress in microfabrication techniques used to mimic liver tissue in vitro. This includes progress and understanding in biomaterials science (cell culture substrate), biomechanics (dynamic cultures conditions) and biology (tissue engineering). The development of new "cell biochips" for chronic toxicology analysis of engineered tissues can be achieved through the combination of these research domains. Combining these advanced research domains, we then present "cell biochips" that allow liver chronic toxicity analysis in vitro on engineered tissues. An extension of the "cell biochip" idea has also allowed "organ interactions on chip", which can be considered as a first step towards the replacement of animal testing using a combined liver/lung organ model.

Exploratory Research and Development Fund, FY 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-05-01

The Lawrence Berkeley Laboratory Exploratory R D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicinemore » and radiation biophysics.« less

Bioprinting is changing regenerative medicine forever.

PubMed

Collins, Scott Forrest

2014-12-01

3D printing, or solid freeform fabrication, applied to regenerative medicine brings technologies from several industries together to help solve unique challenges in both basic science and tissue engineering. By more finely organizing cells and supporting structures precisely in 3D space, we will gain critical knowledge of cell-cell communications and cell-environment interactions. As we increase the scale, we will move toward complex tissue and organ structures where several cell phenotypes will functionally and structurally interact, thus recapitulating the form and function of native tissues and organs.

Bone regeneration and stem cells

PubMed Central

Arvidson, K; Abdallah, B M; Applegate, L A; Baldini, N; Cenni, E; Gomez-Barrena, E; Granchi, D; Kassem, M; Konttinen, Y T; Mustafa, K; Pioletti, D P; Sillat, T; Finne-Wistrand, A

2011-01-01

Abstract This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, effects of sex steroids on mesenchymal stem cells, use of platelet-rich plasma for tissue repair, osteogenesis and its molecular markers. A variety of cells in addition to stem cells, as well as advances in materials science to meet specific requirements for bone and soft tissue regeneration by addition of bioactive molecules, are discussed. PMID:21129153

Fuel Cells for Space Science Applications

NASA Technical Reports Server (NTRS)

Burke, Kenneth A.

2003-01-01

Fuel cell technology has been receiving more attention recently as a possible alternative to the internal combustion engine for our automobile. Improvements in fuel cell designs as well as improvements in lightweight high-pressure gas storage tank technology make fuel cell technology worth a look to see if fuel cells can play a more expanded role in space missions. This study looks at the specific weight density and specific volume density of potential fuel cell systems as an alternative to primary and secondary batteries that have traditionally been used for space missions. This preliminary study indicates that fuel cell systems have the potential for energy densities of greater than 500 W-hr/kg, greater than 500W/kg and greater than 400 W-hr/liter, greater than 200 W/liter. This level of performance makes fuel cells attractive as high-power density, high-energy density sources for space science probes, planetary rovers and other payloads. The power requirements for these space missions are, in general, much lower than the power levels where fuel cells have been used in the past. Adaptation of fuel cells for space science missions will require down-sizing the fuel cell stack and making the fuel cell operate without significant amounts of ancillary equipment.

Outlines on nanotechnologies applied to bladder tissue engineering.

PubMed

Alberti, C

2012-01-01

Tissue engineering technologies are more and more expanding as consequence of recent developments in the field of biomaterial science and nanotechnology research. An important issue in designing scaffold materials is that of recreating the ECM (extra-cellular matrix) functional features - particularly ECM-derived complex molecule signalling - to mimic its capability of directing cell-growth and neotissue morphogenesis. In this way the nanotechnology may offer intriguing chances, biomaterial nanoscale-based scaffold geometry behaving as nanomechanotransducer complex interacting with different cell nanosize proteins, especially with those of cell surface mechanoreceptors. To fabricate 3D-scaffold complex architectures, endowed with controlled geometry and functional properties, bottom-up approaches, based on molecular self-assembling of small building polymer units, are used, sometimes functionalizing them by incorporation of bioactive peptide sequences such as RDG (arginine - glycine - aspartic acid, a cell-integrin binding domain of fibronectin), whereas the top-down approaches are useful to fabricate micro/nanoscale structures, such as a microvasculature within an existing complex bioarchitecture. Synthetic polymer-based nanofibers, produced by electrospinning process, may be used to create fibrous scaffolds that can facilitate, given their nanostructured geometry and surface roughness, cell adhesion and growth. Also bladder tissue engineering may benefit by nanotechnology advances to achieve a better reliability of the bladder engineered tissue. Particularly, bladder smooth muscle cell adhesion to nanostructured polymeric surfaces is significantly enhanced in comparison with that to conventional biomaterials. Moreover nanostructured surfaces of bladder engineered tissue show a decreased calcium stone production. In a bladder tumor animal model, the dispersion of carbon nanofibers in a polymeric scaffold-based tissue engineered replacement neobladder, appears to inhibit a carcinogenic relapse in bladder prosthetic material. Facing the future, a full success of bladder tissue engineering will mainly depend on the progress of both biomaterial nanotechnologies and stem cell biology research.

Army Science and Technology Master Plan, Fiscal Year 1997 - Volume 2.

DTIC Science & Technology

1996-12-01

areas. Microbiology, physiology, and pharmacology are essential sciences in the production of fermented and processed foods (bread, yogurt , beer, wine...engineering) are of significant interest to the U.S. Army, and include production of the material (including cell culture and fermentation ), downstream...remains strong in targeted delivery (associated with MOD laboratories). Hungary has an established capability in production of fermenters . Remediation

Cell-Based Therapeutics: The Next Pillar of Medicine

PubMed Central

Fischbach, Michael A.; Bluestone, Jeffrey A.; Lim, Wendell A.

2013-01-01

Two decades ago, the pharmaceutical industry—long dominated by small-molecule drugs—was revolutionized by the the advent of biologics. Today, biomedicine sits on the cusp of a new revolution: the use of microbial and human cells as versatile therapeutic engines. Here, we discuss the promise of this “third pillar” of therapeutics in the context of current scientific, regulatory, economic, and perceptual challenges. History suggests that the advent of cellular medicines will require the development of a foundational cellular engineering science that provides a systematic framework for safely and predictably altering and regulating cellular behaviors. PMID:23552369

Programming self-organizing multicellular structures with synthetic cell-cell signaling.

PubMed

Toda, Satoshi; Blauch, Lucas R; Tang, Sindy K Y; Morsut, Leonardo; Lim, Wendell A

2018-05-31

A common theme in the self-organization of multicellular tissues is the use of cell-cell signaling networks to induce morphological changes. We used the modular synNotch juxtacrine signaling platform to engineer artificial genetic programs in which specific cell-cell contacts induced changes in cadherin cell adhesion. Despite their simplicity, these minimal intercellular programs were sufficient to yield assemblies with hallmarks of natural developmental systems: robust self-organization into multi-domain structures, well-choreographed sequential assembly, cell type divergence, symmetry breaking, and the capacity for regeneration upon injury. The ability of these networks to drive complex structure formation illustrates the power of interlinking cell signaling with cell sorting: signal-induced spatial reorganization alters the local signals received by each cell, resulting in iterative cycles of cell fate branching. These results provide insights into the evolution of multi-cellularity and demonstrate the potential to engineer customized self-organizing tissues or materials. Copyright © 2018, American Association for the Advancement of Science.

A Program Aimed toward Inclusive Excellence for Underrepresented Undergraduate Women in the Sciences.

PubMed

Katz, Laura A; Aloisio, Kathryn M; Horton, Nicholas J; Ly, Minh; Pruss, Sara; Queeney, Kate; Rowen, Cate; DiBartolo, Patricia Marten

2017-01-01

Created to foster inclusive excellence, Smith College's Achieving Excellence in Mathematics, Engineering, and Science (AEMES) Scholars program provides early faculty-mentored research opportunities and other programming as a way to foster success in academic outcomes for underrepresented women in science. Using academic record data, we compared Scholars' outcomes over time with those of underrepresented students before program launch and to relevant peer comparison groups. Since its launch, AEMES Scholars have achieved significantly higher gateway life sciences course grade point averages (GPAs), rates of persistence in life and natural sciences, and participation in natural sciences advanced research relative to baseline. Gains for Scholars in gateway course GPA eliminated the significant gap that previously existed between science, technology, engineering, and mathematics (STEM)-underrepresented and other students, whereas gains in natural sciences persistence now has Scholars continuing in STEM at significantly higher rates than all other students. Many of the gains for AEMES Scholars were echoed in findings of improved outcomes for our STEM students overall since AEMES' launch. Underrepresented students who were not part of the Scholars program also evidenced increased gateway course GPA over this same period. We discuss potential explanations for these outcomes and ongoing work aimed at achieving further inclusive excellence for women in the sciences. © 2017 L. A. Katz et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Receptor control in mesenchymal stem cell engineering

NASA Astrophysics Data System (ADS)

Dalby, Matthew J.; García, Andrés J.; Salmeron-Sanchez, Manuel

2018-03-01

Materials science offers a powerful tool to control mesenchymal stem cell (MSC) growth and differentiation into functional phenotypes. A complex interplay between the extracellular matrix and growth factors guides MSC phenotypes in vivo. In this Review, we discuss materials-based bioengineering approaches to direct MSC fate in vitro and in vivo, mimicking cell-matrix-growth factor crosstalk. We first scrutinize MSC-matrix interactions and how the properties of a material can be tailored to support MSC growth and differentiation in vitro, with an emphasis on MSC self-renewal mechanisms. We then highlight important growth factor signalling pathways and investigate various materials-based strategies for growth factor presentation and delivery. Integrin-growth factor crosstalk in the context of MSC engineering is introduced, and bioinspired material designs with the potential to control the MSC niche phenotype are considered. Finally, we summarize important milestones on the road to MSC engineering for regenerative medicine.

Global tissue engineering trends. A scientometric and evolutive study.

PubMed

Santisteban-Espejo, Antonio; Campos, Fernando; Martin-Piedra, Laura; Durand-Herrera, Daniel; Moral-Munoz, Jose A; Campos, Antonio; Martin-Piedra, Miguel Angel

2018-04-24

Tissue engineering is defined as a multidisciplinary scientific discipline with the main objective to develop artificial bioengineered living tissues in order to regenerate damaged or lost tissues. Since its appearance in 1988, tissue engineering has globally spreaded in order to improve current therapeutical approaches, entailing a revolution in clinical practice. The aim of this study is to analyze global research trends on tissue engineering publications in order to realize the scenario of tissue engineering research from 1991 to 2016 by using document retrieval from Web of Science database and bibliometric analysis. Document type, language, source title, authorship, countries and filiation centers and citation count were evaluated in 31,859 documents. Obtained results suggest a great multidisciplinary role of tissue engineering due to a wide spectrum -up to 51- of scientific research areas identified in the corpus of literature, being predominant technological disciplines as Material Sciences or Engineering, followed by biological and biomedical areas, as Cell Biology, Biotechnology or Biochemistry. Distribution of authorship, journals and countries revealed a clear imbalance in which a minority is responsible of a majority of documents. Such imbalance is notorious in authorship, where a 0.3% of authors are involved in the half of the whole production.

Targeting CD8+ T-cell tolerance for cancer immunotherapy.

PubMed

Jackson, Stephanie R; Yuan, Jinyun; Teague, Ryan M

2014-01-01

In the final issue of Science in 2013, the American Association of Science recognized progress in the field of cancer immunotherapy as the 'Breakthrough of the Year.' The achievements were actually twofold, owing to the early success of genetically engineered chimeric antigen receptors (CAR) and to the mounting clinical triumphs achieved with checkpoint blockade antibodies. While fundamentally very different, the common thread of these independent strategies is the ability to prevent or overcome mechanisms of CD8(+) T-cell tolerance for improved tumor immunity. Here we discuss how circumventing T-cell tolerance has provided experimental insights that have guided the field of clinical cancer immunotherapy to a place where real breakthroughs can finally be claimed.

Tissue Engineering in Orthopaedics

PubMed Central

Tatara, Alexander M.; Mikos, Antonios G.

2016-01-01

➤ It is important to carefully select the most appropriate combination of scaffold, signals, and cell types when designing tissue engineering approaches for an orthopaedic pathology. ➤ Although clinical studies in which the tissue engineering paradigm has been applied in the treatment of orthopaedic diseases are limited in number, examining them can yield important lessons. ➤ While there is a rapid rate of new discoveries in the basic sciences, substantial regulatory, economic, and clinical issues must be overcome with more consistency to translate a greater number of technologies from the laboratory to the operating room. PMID:27385687

Globalization of Stem Cell Science: An Examination of Current and Past Collaborative Research Networks

PubMed Central

Luo, Jingyuan; Matthews, Kirstin R. W.

2013-01-01

Science and engineering research has becoming an increasingly international phenomenon. Traditional bibliometric studies have not captured the evolution of collaborative partnerships between countries, particularly in emerging technologies such as stem cell science, in which an immense amount of investment has been made in the past decade. Analyzing over 2,800 articles from the top journals that include stem cell research in their publications, this study demonstrates the globalization of stem cell science. From 2000 to 2010, international collaborations increased from 20.9% to 36% of all stem cell publications analyzed. The United States remains the most prolific and the most dominant country in the field in terms of publications in high impact journals. But Asian countries, particularly China are steadily gaining ground. Exhibiting the largest relative growth, the percent of Chinese-authored stem cell papers grew more than ten-fold, while the percent of Chinese-authored international papers increased over seven times from 2000 to 2010. And while the percent of total stem cell publications exhibited modest growth for European countries, the percent of international publications increased more substantially, particularly in the United Kingdom. Overall, the data indicated that traditional networks of collaboration extant in 2000 still predominate in stem cell science. Although more nations are becoming involved in international collaborations and undertaking stem cell research, many of these efforts, with the exception of those in certain Asian countries, have yet to translate into publications in high impact journals. PMID:24069210

Globalization of stem cell science: an examination of current and past collaborative research networks.

PubMed

Luo, Jingyuan; Matthews, Kirstin R W

2013-01-01

Science and engineering research has becoming an increasingly international phenomenon. Traditional bibliometric studies have not captured the evolution of collaborative partnerships between countries, particularly in emerging technologies such as stem cell science, in which an immense amount of investment has been made in the past decade. Analyzing over 2,800 articles from the top journals that include stem cell research in their publications, this study demonstrates the globalization of stem cell science. From 2000 to 2010, international collaborations increased from 20.9% to 36% of all stem cell publications analyzed. The United States remains the most prolific and the most dominant country in the field in terms of publications in high impact journals. But Asian countries, particularly China are steadily gaining ground. Exhibiting the largest relative growth, the percent of Chinese-authored stem cell papers grew more than ten-fold, while the percent of Chinese-authored international papers increased over seven times from 2000 to 2010. And while the percent of total stem cell publications exhibited modest growth for European countries, the percent of international publications increased more substantially, particularly in the United Kingdom. Overall, the data indicated that traditional networks of collaboration extant in 2000 still predominate in stem cell science. Although more nations are becoming involved in international collaborations and undertaking stem cell research, many of these efforts, with the exception of those in certain Asian countries, have yet to translate into publications in high impact journals.

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries.

PubMed

Trzeciak, Tomasz; Richter, Magdalena; Suchorska, Wiktoria; Augustyniak, Ewelina; Lach, Michał; Kaczmarek, Małgorzata; Kaczmarczyk, Jacek

2016-03-01

Over 20 years ago it was realized that the traditional methods of the treatment of injuries to joint components: cartilage, menisci and ligaments, did not give satisfactory results and so there is a need of employing novel, more effective therapeutic techniques. Recent advances in molecular biology, biotechnology and polymer science have led to both the experimental and clinical application of various cell types, adapting their culture conditions in order to ensure a directed differentiation of the cells into a desired cell type, and employing non-toxic and non-immunogenic biomaterial in the treatment of knee joint injuries. In the present review the current state of knowledge regarding novel cell sources, in vitro conditions of cell culture and major important biomaterials, both natural and synthetic, used in cartilage, meniscus and ligament repair by tissue engineering techniques are described, and the assets and drawbacks of their clinical application are critically evaluated.

16 CFR 1000.29 - Directorate for Engineering Sciences.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Directorate for Engineering Sciences. 1000... ORGANIZATION AND FUNCTIONS § 1000.29 Directorate for Engineering Sciences. The Directorate for Engineering Sciences, which is managed by the Associate Executive Director for Engineering Sciences, is responsible for...

16 CFR 1000.29 - Directorate for Engineering Sciences.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Directorate for Engineering Sciences. 1000... ORGANIZATION AND FUNCTIONS § 1000.29 Directorate for Engineering Sciences. The Directorate for Engineering Sciences, which is managed by the Associate Executive Director for Engineering Sciences, is responsible for...

Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

DTIC Science & Technology

2011-07-04

exponential growth mode, where the cell division accelerates and a unicellular organism duplicates, i.e., one cell produces two in a given period of time...AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Georgia Institute of...Technology,School of Materials Science and Engineering,Atlanta,GA,30332 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S

Volatile science? Metabolic engineering of terpenoids in plants.

PubMed

Aharoni, Asaph; Jongsma, Maarten A; Bouwmeester, Harro J

2005-12-01

Terpenoids are important for plant survival and also possess biological properties that are beneficial to humans. Here, we describe the state of the art in terpenoid metabolic engineering, showing that significant progress has been made over the past few years. Subcellular targeting of enzymes has demonstrated that terpenoid precursors in subcellular compartments are not as strictly separated as previously thought and that multistep pathway engineering is feasible, even across cell compartments. These engineered plants show that insect behavior is influenced by terpenoids. In the future, we expect rapid progress in the engineering of terpenoid production in plants. In addition to commercial applications, such transgenic plants should increase our understanding of the biological relevance of these volatile secondary metabolites.

Concise review: tailoring bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine.

PubMed

Cosson, Steffen; Otte, Ellen A; Hezaveh, Hadi; Cooper-White, Justin J

2015-02-01

The potential for the clinical application of stem cells in tissue regeneration is clearly significant. However, this potential has remained largely unrealized owing to the persistent challenges in reproducibly, with tight quality criteria, and expanding and controlling the fate of stem cells in vitro and in vivo. Tissue engineering approaches that rely on reformatting traditional Food and Drug Administration-approved biomedical polymers from fixation devices to porous scaffolds have been shown to lack the complexity required for in vitro stem cell culture models or translation to in vivo applications with high efficacy. This realization has spurred the development of advanced mimetic biomaterials and scaffolds to increasingly enhance our ability to control the cellular microenvironment and, consequently, stem cell fate. New insights into the biology of stem cells are expected to eventuate from these advances in material science, in particular, from synthetic hydrogels that display physicochemical properties reminiscent of the natural cell microenvironment and that can be engineered to display or encode essential biological cues. Merging these advanced biomaterials with high-throughput methods to systematically, and in an unbiased manner, probe the role of scaffold biophysical and biochemical elements on stem cell fate will permit the identification of novel key stem cell behavioral effectors, allow improved in vitro replication of requisite in vivo niche functions, and, ultimately, have a profound impact on our understanding of stem cell biology and unlock their clinical potential in tissue engineering and regenerative medicine. ©AlphaMed Press.

16 CFR § 1000.29 - Directorate for Engineering Sciences.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Directorate for Engineering Sciences. Â... ORGANIZATION AND FUNCTIONS § 1000.29 Directorate for Engineering Sciences. The Directorate for Engineering Sciences, which is managed by the Associate Executive Director for Engineering Sciences, is responsible for...

White House Science Fair

NASA Image and Video Library

2014-05-27

Crystal Brockington and Aaron Barron, both 18 years old, designed a more efficient and cost effective solar cell that harnesses energy without cadmium, which has been shown to be harmful to the environment. They were selected to participate in the White House Science Fair after they were awarded the High School Grand Prize at the Siemens We Can Change the World Challenge. The fourth White House Science Fair was held at the White House on May 27, 2014 and included 100 students from more than 30 different states who competed in science, technology, engineering, and math (STEM) competitions. (Photo Credit: NASA/Aubrey Gemignani)

Teaching cell and molecular biology for gender equity.

PubMed

Sible, Jill C; Wilhelm, Dayna E; Lederman, Muriel

2006-01-01

Science, technology, engineering, and math (STEM) fields, including cell biology, are characterized by the "leaky pipeline" syndrome in which, over time, women leave the discipline. The pipeline itself and the pond into which it empties may not be neutral. Explicating invisible norms, attitudes, and practices by integrating social studies of science into science education may be the necessary first step in helping female students persist in STEM disciplines. In 2003 and 2004, a sophomore Cell and Molecular Biology course at Virginia Tech (Blacksburg, VA) was taught integrating social studies of science with standard material. The course was successfully implemented, teaching students factual content while increasing awareness of the cultures of science and their self-confidence in engaging with the subject. Course evaluation data indicated that females in particular perceived greater gains in logical thinking and problem-solving abilities than females in a traditional cell biology course. Consistent with K-12 studies, males in this class were likely to view scientists as male only, whereas females viewed scientists as male and female. This pilot project demonstrates that social studies can be integrated successfully in a cell biology course. Longitudinal studies of this cohort of students will indicate whether this approach contributes to the retention of women in the field.

Use of bioreactors in maxillofacial tissue engineering.

PubMed

Depprich, Rita; Handschel, Jörg; Wiesmann, Hans-Peter; Jäsche-Meyer, Janine; Meyer, Ulrich

2008-07-01

Engineering of various oral tissues is a challenging issue in contemporary maxillofacial reconstructive research. In contrast to the classic biomaterial approach, tissue engineering is based on the understanding of cell driven tissue formation, and aims to generate new functional tissues, rather than just to implant non-living space holders. Researchers hope to reach this goal by combining knowledge from biology, physics, materials science, engineering, and medicine in an integrated manner. Several major technical advances have been made in this field during the last decade, and clinical application is at the stage of first clinical trials. A recent limitation of extracorporally engineered cellular substitutes is the problem of growing enlarged tissues ex vivo. One of the main research topics is therefore to scale up artificial tissue constructs for use in extended defect situations. To overcome the monolayer inherent two-dimensional cell assembly, efforts have been made to grow cells in a three-dimensional space. Bioreactors have therefore been in focus for a considerable time to build up enlarged tissues. The shift from the ex vivo approach of cell multiplication to the generation of a real tissue growth is mirrored by the development of bioreactors, enabling scientists to grow more complex tissue constructs. This present review intends to provide an overview of the current state of art in maxillofacial tissue engineering by the use of bioreactors, its limitations and hopes, as well as the future research trends.

An update to space biomedical research: tissue engineering in microgravity bioreactors.

PubMed

Barzegari, Abolfazl; Saei, Amir Ata

2012-01-01

The severe need for constructing replacement tissues in organ transplanta-tion has necessitated the development of tissue engineering approaches and bioreactors that can bring these approaches to reality. The inherent limitations of conventional bioreactors in generating realistic tissue constructs led to the devise of the microgravity tissue engineering that uses Rotating Wall Vessel (RWV) bioreactors initially developed by NASA. In this review article, we intend to highlight some major advances and accomplishments in the rapidly-growing field of tissue engineering that could not be achieved without using microgravity. Research is now focused on assembly of 3 dimensional (3D) tissue fragments from various cell types in human body such as chon-drocytes, osteoblasts, embryonic and mesenchymal stem cells, hepatocytes and pancreas islet cells. Hepatocytes cultured under microgravity are now being used in extracorporeal bioartificial liver devices. Tissue constructs can be used not only in organ replacement therapy, but also in pharmaco-toxicology and food safety assessment. 3D models of vari-ous cancers may be used in studying cancer development and biology or in high-throughput screening of anticancer drug candidates. Finally, 3D heterogeneous assemblies from cancer/immune cells provide models for immunotherapy of cancer. Tissue engineering in (simulated) microgravity has been one of the stunning impacts of space research on biomedical sciences and their applications on earth.

Exploratory Research and Development Fund, FY 1990. Report on Lawrence Berkeley Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-05-01

The Lawrence Berkeley Laboratory Exploratory R&D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R&D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiationmore » biophysics.« less

The past, present and future of ligament regenerative engineering

PubMed Central

Mengsteab, Paulos Y; Nair, Lakshmi S; Laurencin, Cato T

2016-01-01

Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, ligament and their interface to achieve superior clinical results. In the past, the ACL has been repaired with the use of autologous and allogeneic grafts, which have their respective drawbacks. Currently, investigations on the use of biodegradable matrices to achieve knee stability and permit tissue regeneration are making promising advancements. In the future, utilizing regenerative biology cues to induce an endogenous regenerative response may aid the enhancement of clinical ACL reconstruction outcomes. PMID:27879170

The past, present and future of ligament regenerative engineering.

PubMed

Mengsteab, Paulos Y; Nair, Lakshmi S; Laurencin, Cato T

2016-12-01

Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, ligament and their interface to achieve superior clinical results. In the past, the ACL has been repaired with the use of autologous and allogeneic grafts, which have their respective drawbacks. Currently, investigations on the use of biodegradable matrices to achieve knee stability and permit tissue regeneration are making promising advancements. In the future, utilizing regenerative biology cues to induce an endogenous regenerative response may aid the enhancement of clinical ACL reconstruction outcomes.

Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia coli Metabolism

PubMed Central

Shimizu, Kazuyuki

2013-01-01

It is quite important to understand the overall metabolic regulation mechanism of bacterial cells such as Escherichia coli from both science (such as biochemistry) and engineering (such as metabolic engineering) points of view. Here, an attempt was made to clarify the overall metabolic regulation mechanism by focusing on the roles of global regulators which detect the culture or growth condition and manipulate a set of metabolic pathways by modulating the related gene expressions. For this, it was considered how the cell responds to a variety of culture environments such as carbon (catabolite regulation), nitrogen, and phosphate limitations, as well as the effects of oxygen level, pH (acid shock), temperature (heat shock), and nutrient starvation. PMID:25937963

Science Outside the Lab: Helping Graduate Students in Science and Engineering Understand the Complexities of Science Policy.

PubMed

Bernstein, Michael J; Reifschneider, Kiera; Bennett, Ira; Wetmore, Jameson M

2017-06-01

Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre-post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes.

Emerging Perspectives in Scaffold for Tissue Engineering in Oral Surgery.

PubMed

Ceccarelli, Gabriele; Presta, Rossella; Benedetti, Laura; Cusella De Angelis, Maria Gabriella; Lupi, Saturnino Marco; Rodriguez Y Baena, Ruggero

2017-01-01

Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors. The biomimetic approach to create an ideal bone substitute provides strategies for developing combined scaffolds composed of adult stem cells with mesenchymal phenotype and different organic biomaterials (such as collagen and hyaluronic acid derivatives) or inorganic biomaterials such as manufactured polymers (polyglycolic acid (PGA), polylactic acid (PLA), and polycaprolactone). This review focuses on different biomaterials currently used in dentistry as scaffolds for bone regeneration in treating bone defects or in surgical techniques, such as sinus lift, horizontal and vertical bone grafts, or socket preservation. Our review would be of particular interest to medical and surgical researchers at the interface of cell biology, materials science, and tissue engineering, as well as industry-related manufacturers and researchers in healthcare, prosthetics, and 3D printing, too.

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice

PubMed Central

Al-Himdani, Sarah; Jessop, Zita M.; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H.; Hart, Andrew M.; Archer, Charles W.; Thornton, Catherine A.; Whitaker, Iain S.

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering “holds the promise of revolutionizing patient care in the twenty-first century.” The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20–30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions. PMID:28280722

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice.

PubMed

Al-Himdani, Sarah; Jessop, Zita M; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H; Hart, Andrew M; Archer, Charles W; Thornton, Catherine A; Whitaker, Iain S

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering "holds the promise of revolutionizing patient care in the twenty-first century." The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20-30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions.

Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

PubMed Central

2016-01-01

Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation. PMID:27516776

75 FR 62591 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Equal Opportunities in Science and Engineering (1173). Dates/Time: October 25, 2010, 8:30 a.m.-5:30 p.m... the National Science Foundation (NSF) concerning broadening participation in science and engineering...

DomeGene Sample Removal from Cell Biology Experiment Facility (CBEF)

NASA Image and Video Library

2009-03-28

ISS018-E-044235 (28 March 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 18/19 flight engineer, works on an experiment at the Ryutai fluid science experiment rack in the Kibo laboratory of the International Space Station.

The Impact of Design-Based STEM Integration Curricula on Student Achievement in Engineering, Science, and Mathematics

NASA Astrophysics Data System (ADS)

Selcen Guzey, S.; Harwell, Michael; Moreno, Mario; Peralta, Yadira; Moore, Tamara J.

2017-04-01

The new science education reform documents call for integration of engineering into K-12 science classes. Engineering design and practices are new to most science teachers, meaning that implementing effective engineering instruction is likely to be challenging. This quasi-experimental study explored the influence of teacher-developed, engineering design-based science curriculum units on learning and achievement among grade 4-8 students of different races, gender, special education status, and limited English proficiency (LEP) status. Treatment and control students ( n = 4450) completed pretest and posttest assessments in science, engineering, and mathematics as well as a state-mandated mathematics test. Single-level regression results for science outcomes favored the treatment for one science assessment (physical science, heat transfer), but multilevel analyses showed no significant treatment effect. We also found that engineering integration had different effects across race and gender and that teacher gender can reduce or exacerbate the gap in engineering achievement for student subgroups depending on the outcome. Other teacher factors such as the quality of engineering-focused science units and engineering instruction were predictive of student achievement in engineering. Implications for practice are discussed.

Polymeric scaffolds as stem cell carriers in bone repair.

PubMed

Rossi, Filippo; Santoro, Marco; Perale, Giuseppe

2015-10-01

Although bone has a high potential to regenerate itself after damage and injury, the efficacious repair of large bone defects resulting from resection, trauma or non-union fractures still requires the implantation of bone grafts. Materials science, in conjunction with biotechnology, can satisfy these needs by developing artificial bones, synthetic substitutes and organ implants. In particular, recent advances in polymer science have provided several innovations, underlying the increasing importance of macromolecules in this field. To address the increasing need for improved bone substitutes, tissue engineering seeks to create synthetic, three-dimensional scaffolds made from polymeric materials, incorporating stem cells and growth factors, to induce new bone tissue formation. Polymeric materials have shown a great affinity for cell transplantation and differentiation and, moreover, their structure can be tuned in order to maintain an adequate mechanical resistance and contemporarily be fully bioresorbable. This review emphasizes recent progress in polymer science that allows relaible polymeric scaffolds to be synthesized for stem cell growth in bone regeneration. Copyright © 2013 John Wiley & Sons, Ltd.

Anhydrobiotic engineering of bacterial and mammalian cells: is intracellular trehalose sufficient?

PubMed

Tunnacliffe, A; García de Castro, A; Manzanera, M

2001-09-01

Anhydrobiotic engineering aims to confer a high degree of desiccation tolerance on otherwise sensitive living organisms and cells by adopting the strategies of anhydrobiosis. Nonreducing disaccharides such as trehalose and sucrose are thought to play a pivotal role in resistance to desiccation stress in many microorganisms, invertebrates, and plants, and in vitro trehalose is known to confer stability on dried biomolecules and biomembranes. We have therefore tested the hypothesis that intracellular trehalose (or a similar molecule) may be not only necessary for anhydrobiosis but also sufficient. High concentrations of trehalose were produced in bacteria by osmotic preconditioning, and in mammalian cells by genetic engineering, but in neither system was desiccation tolerance similar to that seen in anhydrobiotic organisms, suggesting that trehalose alone is not sufficient for anhydrobiosis. In Escherichia coli such desiccation tolerance was achievable, but only when bacteria were dried in the presence of both extracellular trehalose and intracellular trehalose. In mouse L cells, improved osmotolerance was observed with up to 100 mM intracellular trehalose, but desiccation was invariably lethal even with extracellular trehalose present. We conclude that anhydrobiotic engineering of at least some microorganisms is achievable with present technology, but that further advances are needed for similar desiccation tolerance of mammalian cells. Copyright 2001 Elsevier Science (USA).

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

PubMed

Ivanov, D P; Walker, D A; Coyle, B; Grabowska, A M

2016-12-01

This article collates information about the number of scientific articles mentioning each of the established medulloblastoma cell lines, derived through a systematic search of Web of Science, Scopus and Google Scholar in 2016. The data for each cell line have been presented as raw number of citations, percentage share of the total citations for each search engine and as an average percentage between the three search engines. In order to correct for the time since each cell line has been in use, the raw citation data have also been divided by the number of years since the derivation of each cell line. This is a supporting article for a review of in vitro models of medulloblastoma published in "in vitro models of medulloblastoma: choosing the right tool for the job" (D.P. Ivanov, D.A. Walker, B. Coyle, A.M. Grabowska, 2016) [1].

Proceedings of the 21st Project Integration Meeting

NASA Technical Reports Server (NTRS)

1983-01-01

Progress made by the Flat Plate Solar Array Project during the period April 1982 to January 1983 is described. Reports on polysilicon refining, thin film solar cell and module technology development, central station electric utility activities, silicon sheet growth and characteristics, advanced photovoltaic materials, cell and processes research, module technology, environmental isolation, engineering sciences, module performance and failure analysis and project analysis and integration are included.

Decision Analysis: Engineering Science or Clinical Art

DTIC Science & Technology

1979-11-01

TECHNICAL REPORT TR 79-2-97 DECISION ANALYSIS: ENGINEERING SCIENCE OR CLINICAL ART ? by Dennis M. Buede Prepared for Defense Advanced Research...APPLICATIONS OF THE ENGINEER- ING SCIENCE AND CLINICAL ART EXTREMES 9 3.1 Applications of the Engineering Science Approach 9 3.1.1 Mexican electrical...DISCUSSION 29 4.1 Engineering Science versus Clinical Art : A Characterization of When Each is Most Attractive 30 4.2 The Implications of the Engineering

The Impact of Engineering Integrated Science (EIS) Curricula on First-Year Technical High School Students' Attitudes toward Science and Perceptions of Engineering

ERIC Educational Resources Information Center

Nam, Younkyeong; Lee, Sun-Ju; Paik, Seoung-Hey

2016-01-01

This study investigated how engineering integrated science (EIS) curricula affect first-year technical high school students' attitudes toward science and perceptions of engineering. The effect of the EIS participation period on students' attitudes toward science was also investigated via experimental study design. Two engineering integrated…

Science Teachers' Misconceptions in Science and Engineering Distinctions: Reflections on Modern Research Examples

NASA Astrophysics Data System (ADS)

Antink-Meyer, Allison; Meyer, Daniel Z.

2016-10-01

The aim of this exploratory study was to learn about the misconceptions that may arise for elementary and high school science teachers in their reflections on science and engineering practice. Using readings and videos of real science and engineering work, teachers' reflections were used to uncover the underpinnings of their understandings. This knowledge ultimately provides information about supporting professional development (PD) for science teachers' knowledge of engineering. Six science teachers (two elementary and four high school teachers) participated in the study as part of an online PD experience. Cunningham and Carlsen's (Journal of Science Teacher Education 25:197-210, 2014) relative emphases of science and engineering practices were used to frame the design of PD activities and the analyses of teachers' views. Analyses suggest misconceptions within the eight practices of science and engineering from the US Next Generation Science Standards in four areas. These are that: (1) the nature of the practices in both science and engineering research is determined by the long-term implications of the research regardless of the nature of the immediate work, (2) engineering and science are hierarchical, (3) creativity is inappropriate, and (4) research outcomes cannot be processes. We discuss the nature of these understandings among participants and the implications for engineering education PD for science teachers.

SYNTHETIC BIOLOGY. Emergent genetic oscillations in a synthetic microbial consortium.

PubMed

Chen, Ye; Kim, Jae Kyoung; Hirning, Andrew J; Josić, Krešimir; Bennett, Matthew R

2015-08-28

A challenge of synthetic biology is the creation of cooperative microbial systems that exhibit population-level behaviors. Such systems use cellular signaling mechanisms to regulate gene expression across multiple cell types. We describe the construction of a synthetic microbial consortium consisting of two distinct cell types—an "activator" strain and a "repressor" strain. These strains produced two orthogonal cell-signaling molecules that regulate gene expression within a synthetic circuit spanning both strains. The two strains generated emergent, population-level oscillations only when cultured together. Certain network topologies of the two-strain circuit were better at maintaining robust oscillations than others. The ability to program population-level dynamics through the genetic engineering of multiple cooperative strains points the way toward engineering complex synthetic tissues and organs with multiple cell types. Copyright © 2015, American Association for the Advancement of Science.

76 FR 4138 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: February 8, 2011, 9 a.m.-5:30 p.m. February 9, 2011... National Science Foundation (NSF) concerning broadening participation in science and engineering. Agenda...

78 FR 13384 - Advisory Committee for International Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science and Engineering; Notice... Science and Engineering (25104). Date/Time: March 14, 2013 9:30 a.m.-5:00 p.m. March 15, 2013 8:30 a.m.-12... of International Science and Engineering, National Science Foundation, 4201 Wilson Blvd., Arlington...

Targeting CD8+ T-cell tolerance for cancer immunotherapy

PubMed Central

Jackson, Stephanie R; Yuan, Jinyun; Teague, Ryan M

2014-01-01

In the final issue of Science in 2013, the American Association of Science recognized progress in the field of cancer immunotherapy as the ‘Breakthrough of the Year.’ The achievements were actually twofold, owing to the early success of genetically engineered chimeric antigen receptors (CAR) and to the mounting clinical triumphs achieved with checkpoint blockade antibodies. While fundamentally very different, the common thread of these independent strategies is the ability to prevent or overcome mechanisms of CD8+ T-cell tolerance for improved tumor immunity. Here we discuss how circumventing T-cell tolerance has provided experimental insights that have guided the field of clinical cancer immunotherapy to a place where real breakthroughs can finally be claimed. PMID:25290416

Multimedia: Developing Creativity and Innovation in Engineering, Science,

Science.gov Websites

Find ScienceCinema Search Results Multimedia: Developing Creativity and Innovation in Engineering , Science, and Medicine Citation Details Title: Developing Creativity and Innovation in Engineering, Science , and Medicine Title: Developing Creativity and Innovation in Engineering, Science, and Medicine Authors

Environmental Measurements in the Beaufort Sea, Spring 1988

DTIC Science & Technology

1989-03-01

electrical cable. The sensor package consisted of a thermistor (Sea-Bird), a conductivity cell (Sea-Bird), a pressure sensor (Paroscientific Digiquartz), and... Frankenstein and Garner9 based on the measured temperature (0Q and salinity (%o): Vb = S (-52.56/T - 2.28) for -0.5 >T >-2.06 Vb =S (-45.917/T + 0.93...Science and Engineering Monograph II-C3, Cold Regions Research and Engineer- ing Laboratory, Hanover, NH, 1967. 9. F. Frankenstein and R. Garner

Driving Pockels Cells Using Avalanche Transistor Pulsers

DTIC Science & Technology

1997-06-01

High Voltage Avalanche Transistor Pulsers", 21st International Power Modulator Symposium, Costa Mesa, CA, June 1994 2 CRC Handbook of Applied ... Engineering Science 200 Edition 1976 Table 7-44 Velocity of Sound in Bar-Shaped Solids Longitudinal Direction Potassium chloride (KCl, sylvite) X-cut 1346

Biomanufacturing: a US-China National Science Foundation-sponsored workshop.

PubMed

Sun, Wei; Yan, Yongnian; Lin, Feng; Spector, Myron

2006-05-01

A recent US-China National Science Foundation-sponsored workshop on biomanufacturing reviewed the state-of-the-art of an array of new technologies for producing scaffolds for tissue engineering, providing precision multi-scale control of material, architecture, and cells. One broad category of such techniques has been termed solid freeform fabrication. The techniques in this category include: stereolithography, selected laser sintering, single- and multiple-nozzle deposition and fused deposition modeling, and three-dimensional printing. The precise and repetitive placement of material and cells in a three-dimensional construct at the micrometer length scale demands computer control. These novel computer-controlled scaffold production techniques, when coupled with computer-based imaging and structural modeling methods for the production of the templates for the scaffolds, define an emerging field of computer-aided tissue engineering. In formulating the questions that remain to be answered and discussing the knowledge required to further advance the field, the Workshop provided a basis for recommendations for future work.

Restoring the magnetism of ultrathin LaMn O3 films by surface symmetry engineering

NASA Astrophysics Data System (ADS)

Peng, J. J.; Song, C.; Li, F.; Gu, Y. D.; Wang, G. Y.; Pan, F.

2016-12-01

The frustration of magnetization and conductivity properties of ultrathin manganite is detrimental to their device performance, preventing their scaling down process. Here we demonstrate that the magnetism of ultrathin LaMn O3 films can be restored by a SrTi O3 capping layer, which engineers the surface from a symmetry breaking induced out-of-plane orbital occupancy to the recovered in-plane orbital occupancy. The stabilized in-plane orbital occupancy would strengthen the intralayer double exchange and thus recovers the robust magnetism. This method is proved to be effective for films as thin as 2 unit cells, greatly shrinking the critical thickness of 6 unit cells for ferromagnetic LaMn O3 as demonstrated previously [Wang et al., Science 349, 716 (2015), 10.1126/science.aaa5198]. The achievement made in this work opens up new perspectives to an active control of surface states and thereby tailors the surface functional properties of transition metal oxides.

Materials Science & Engineering | Classification | College of Engineering &

Science.gov Websites

ChairMaterials Science and Engineering(414) 229-2668nidal@uwm.eduEng & Math Sciences E351 profile photo (414) 229-2615jhchen@uwm.eduEng & Math Sciences 1225 profile photo Benjamin Church, Ph.D.Associate ProfessorMaterials Science & Engineering(414) 229-2825church@uwm.eduEng & Math Sciences EMS 1175 profile

Solar cell and photonics outreach for middle school students and teachers

NASA Astrophysics Data System (ADS)

Gilchrist, Pamela O.; Alexander, Alonzo B.

2017-08-01

This paper will describe the curriculum development process employed to develop a solar cell and photonics curriculum unit for students underrepresented in science, technology, engineering and mathematics fields. Information will explain how the curriculum unit was piloted with middle and high school teachers from public schools in North Carolina, high school students from underrepresented groups in an informal science program, and workshop settings. Measures used to develop the curriculum materials for middle school students will be presented along with program findings documenting students' urban versus rural interest in STEM, career aspirations, and 21st century learning skills in informal learning settings.

78 FR 13743 - Requirements for the Recognizing Aviation and Aerospace Innovation in Science and Engineering...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... Aerospace Innovation in Science and Engineering (RAISE) Award AGENCY: Office of the Secretary, U.S... demonstrate unique, innovative thinking in aerospace science and engineering. With this award, the Secretary... Science and Engineering) Award will recognize innovative scientific and engineering achievements that will...

Engineering Encounters: Engineer It, Learn It--Science and Engineering Practices in Action

ERIC Educational Resources Information Center

Lachapelle, Cathy P.; Sargianis, Kristin; Cunningham, Christine M.

2013-01-01

Engineering is prominently included in the "Next Generation Science Standards" (Achieve Inc. 2013), as it was in "A Framework for K-12 Science Education" (NRC 2012). The National Research Council, authors of the "Framework," write, "Engineering and technology are featured alongside the natural sciences (physical…

Science & Engineering Indicators. National Science Board. NSB 14-01

ERIC Educational Resources Information Center

National Science Foundation, 2014

2014-01-01

The "Science and Engineering Indicators" series was designed to provide a broad base of quantitative information about U.S. science, engineering, and technology for use by policymakers, researchers, and the general public. "Science and Engineering Indicators 2014" contains analyses of key aspects of the scope, quality, and…

77 FR 6143 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: February 28, 2012, 9 a.m.-5:30 p.m., February 29... provide advice and recommendations concerning broadening participation in science and engineering. Agenda...

76 FR 4138 - Committee on Equal Opportunity in Science and Engineering Solicitation of Recommendations for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunity in Science and Engineering Solicitation... recommendations for membership on the Committee on Equal Opportunities in Science and Engineering (CEOSE) (1173... provides advice to NSF on the implementation of the provisions of the Science and Engineering Equal...

77 FR 30029 - Advisory Committee for International Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science and Engineering; Notice... Science and Engineering (25104). Date and Time: June 11, 2012, 10:00 a.m.-12:00 p.m. Place.... Contact Person for More Information: Robert Webber, Office of International Science and Engineering...

78 FR 60918 - Committee on Equal Opportunities in Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering; Notice of... Engineering (1173). Dates/Time: October 30, 2013, 10:00 a.m.-3:30 p.m. Place: National Science Foundation... advice and recommendations concerning broadening participation in science and engineering. Agenda...

Recent advances in endocrine, metabolic and immune disorders: mesenchymal stem cells (MSCs) and engineered scaffolds.

PubMed

Cantore, Stefania; Crincoli, Vito; Boccaccio, Antonio; Uva, Antonio Emmanuele; Fiorentino, Michele; Monno, Giuseppe; Bollero, Patrizio; Derla, Chiara; Fabiano, Francesca; Ballini, Andrea; Santacroce, Luigi

2018-04-22

New sources of stem cells in adult organisms are constantly emerging. Postnatal Mesenchymal Stem Cells (MSCs), are the most promising support to perform an effective regenerative medicine: such cells have the ability to differentiate into several lineages, such as osteoblasts and chondroblasts, providing novel strategies to improve different complex treatments, during bone regeneration. 3D-printed biomaterials can be designed with geometry aimed to induce stem cells to differentiate towards specific lineage. The interaction between stem cells easy to isolate and engineered 3D-printed scaffolds can translate the tissue bio-engineering into bone regenerative surgery. For those reasons, to better identify the complexity represented by the activities and responses of MSCs requires the advance of new target therapies which are not current in endocrine, metabolic and immune disorders and yet to be developed. This topical review briefly focuses on the new approaches of translational medicine with the use of MSCs and scaffolds engineered with the aid of 3D-printing technology, highlights the osteogenic functions then addressing their applications across the breadth of regenerative medicine. The application of bone constructs consisting of engineered scaffold and MSCs as well as the aspects related to the optimal scaffold geometry that favours the best MSCs differentiation and the improvement of concepts as "sensing surface" were also discussed. Regenerative surgery is largely growing in the field of translational medicine. The use of new sources of MSCs and the improvement of new concepts of bio-engineered scaffolds will certainly be the next step of customized medicine. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Practical Strategy on the Subject of “Science and Ethics” for Overcoming Hybrid Engineering Ethics Education

NASA Astrophysics Data System (ADS)

Yasui, Yoshiaki

The issue of economic globalization and JABEE (Japan Accreditation Board for Engineering Education) mean that education on engineering ethics has now become increasingly important for science-engineering students who will become the next generation of engineers. This is clearly indicated when engineers are made professionally responsible for various unfortunate accidents that happen during daily life in society. Learning hybrid engineering ethics is an essential part of the education of the humanities and sciences. This paper treats the contents for the subject of “Science and Ethics” drawing on several years of practice and the fruits of studying science and engineering ethics at the faculty of science-engineering in university. This paper can be considered to be a practical strategy to the formation of morality.

Tissue engineering strategies in spinal arthrodesis: the clinical imperative and challenges to clinical translation.

PubMed

Evans, Nick R; Davies, Evan M; Dare, Chris J; Oreffo, Richard Oc

2013-01-01

Skeletal disorders requiring the regeneration or de novo production of bone present considerable reconstructive challenges and are one of the main driving forces for the development of skeletal tissue engineering strategies. The skeletal or mesenchymal stem cell is a fundamental requirement for osteogenesis and plays a pivotal role in the design and application of these strategies. Research activity has focused on incorporating the biological role of the mesenchymal stem cell with the developing fields of material science and gene therapy in order to create a construct that is not only capable of inducing host osteoblasts to produce bone, but is also osteogenic in its own right. This review explores the clinical need for reparative approaches in spinal arthrodesis, identifying recent tissue engineering strategies employed to promote spinal fusion, and considers the ongoing challenges to successful clinical translation.

Stem cell research and transplantation: science leading ethics.

PubMed

Daar, A S; Bhatt, A; Court, E; Singer, P A

2004-10-01

One of the most exciting developments in the biological sciences in the past decade has been the discovery and characterization of human embryonic stem cells (ESCs). The interest to transplanters is the potential applications of stem cells in regenerative medicine (RM), which may involve tissue engineering, genetic engineering, and other techniques to repair, replace, or regenerate failing tissues and organs. There is little controversy surrounding human adult stem cells. However, human ESCs are surrounded by a number of ethical controversies, the extent of which is partly dependent on their source. Those derived from currently existing embryonic stem cell lines are less controversial than those derived from "excess" embryos from in vitro fertilization (IVF) clinics, while ESCs derived from IVF embryos specifically created for the purpose are not acceptable to many people arguing from religious and other moral perspectives. Somatic cell nuclear transfer, or therapeutic cloning, must be distinguished from reproductive cloning. It holds the most promise for regenerative medicine. ESCs can also be derived from gonadal ridges of aborted fetuses. The transplant community must strive to uphold societal values in its effort to find remedies for their ailing patients and address the perennial problem of organ shortage. Transplanters also have a responsibility to engage the public in their efforts to gain public understanding and support, and policy makers must take into account public opinion. Only in this way can we realize the great potential of stem cell research for organ transplantation.

Effects of Engineering Design-Based Science on Elementary School Science Students' Engineering Identity Development across Gender and Grade

NASA Astrophysics Data System (ADS)

Capobianco, Brenda M.; Yu, Ji H.; French, Brian F.

2015-04-01

The integration of engineering concepts and practices into elementary science education has become an emerging concern for science educators and practitioners, alike. Moreover, how children, specifically preadolescents (grades 1-5), engage in engineering design-based learning activities may help science educators and researchers learn more about children's earliest identification with engineering. The purpose of this study was to examine the extent to which engineering identity differed among preadolescents across gender and grade, when exposing students to engineering design-based science learning activities. Five hundred fifty preadolescent participants completed the Engineering Identity Development Scale (EIDS), a recently developed measure with validity evidence that characterizes children's conceptions of engineering and potential career aspirations. Data analyses of variance among four factors (i.e., gender, grade, and group) indicated that elementary school students who engaged in the engineering design-based science learning activities demonstrated greater improvements on the EIDS subscales compared to those in the comparison group. Specifically, students in the lower grade levels showed substantial increases, while students in the higher grade levels showed decreases. Girls, regardless of grade level and participation in the engineering learning activities, showed higher scores in the academic subscale compared to boys. These findings suggest that the integration of engineering practices in the science classroom as early as grade one shows potential in fostering and sustaining student interest, participation, and self-concept in engineering and science.

Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue.

PubMed

Taraballi, Francesca; Bauza, Guillermo; McCulloch, Patrick; Harris, Josh; Tasciotti, Ennio

2017-12-01

Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186-2196. © 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Tissue engineering therapy for cardiovascular disease.

PubMed

Nugent, Helen M; Edelman, Elazer R

2003-05-30

The present treatments for the loss or failure of cardiovascular function include organ transplantation, surgical reconstruction, mechanical or synthetic devices, or the administration of metabolic products. Although routinely used, these treatments are not without constraints and complications. The emerging and interdisciplinary field of tissue engineering has evolved to provide solutions to tissue creation and repair. Tissue engineering applies the principles of engineering, material science, and biology toward the development of biological substitutes that restore, maintain, or improve tissue function. Progress has been made in engineering the various components of the cardiovascular system, including blood vessels, heart valves, and cardiac muscle. Many pivotal studies have been performed in recent years that may support the move toward the widespread application of tissue-engineered therapy for cardiovascular diseases. The studies discussed include endothelial cell seeding of vascular grafts, tissue-engineered vascular conduits, generation of heart valve leaflets, cardiomyoplasty, genetic manipulation, and in vitro conditions for optimizing tissue-engineered cardiovascular constructs.

Current status of Westinghouse tubular solid oxide fuel cell program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, W.G.

1996-04-01

In the last ten years the solid oxide fuel cell (SOFC) development program at Westinghouse has evolved from a focus on basic material science to the engineering of fully integrated electric power systems. Our endurance for this cell is 5 to 10 years. To date we have successfully operated at power for over six years. For power plants it is our goal to have operated before the end of this decade a MW class power plant. Progress toward these goals is described.

Science in 60 – A Clean, Renewable Power Source

ScienceCinema

Borup, Rod

2018-06-12

Fuel cells have long been one of the most tantalizing clean-energy solutions. They offer electricity from an abundant energy source—hydrogen. Compared to internal combustion engines, fuel cells are more than twice as efficient at converting fuel to power, but are currently dependent on costly platinum. Rod Borup and his team at Los Alamos National Lab are leading efforts to reduce the cost of fuel cells and are exploring alternatives that could eliminate platinum all together.

Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue

PubMed Central

Taraballi, Francesca; Bauza, Guillermo; McCulloch, Patrick; Harris, Josh

2017-01-01

Abstract Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting‐edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186–2196 PMID:29080279

34 CFR 637.1 - What is the Minority Science and Engineering Improvement Program (MSEIP)?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false What is the Minority Science and Engineering... ENGINEERING IMPROVEMENT PROGRAM General § 637.1 What is the Minority Science and Engineering Improvement Program (MSEIP)? The Minority Science and Engineering Improvement Program (MSEIP) is designed to effect...

34 CFR 637.1 - What is the Minority Science and Engineering Improvement Program (MSEIP)?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Minority Science and Engineering... ENGINEERING IMPROVEMENT PROGRAM General § 637.1 What is the Minority Science and Engineering Improvement Program (MSEIP)? The Minority Science and Engineering Improvement Program (MSEIP) is designed to effect...

34 CFR 637.1 - What is the Minority Science and Engineering Improvement Program (MSEIP)?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false What is the Minority Science and Engineering... ENGINEERING IMPROVEMENT PROGRAM General § 637.1 What is the Minority Science and Engineering Improvement Program (MSEIP)? The Minority Science and Engineering Improvement Program (MSEIP) is designed to effect...

34 CFR 637.1 - What is the Minority Science and Engineering Improvement Program (MSEIP)?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What is the Minority Science and Engineering... ENGINEERING IMPROVEMENT PROGRAM General § 637.1 What is the Minority Science and Engineering Improvement Program (MSEIP)? The Minority Science and Engineering Improvement Program (MSEIP) is designed to effect...

34 CFR 637.1 - What is the Minority Science and Engineering Improvement Program (MSEIP)?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What is the Minority Science and Engineering... ENGINEERING IMPROVEMENT PROGRAM General § 637.1 What is the Minority Science and Engineering Improvement Program (MSEIP)? The Minority Science and Engineering Improvement Program (MSEIP) is designed to effect...

Operationalizing Mobile Applications for Humanitarian Assistance/Disaster Relief Missions

DTIC Science & Technology

2014-03-01

FLAK, equipped with BGAN, WiMAX and meshed Wi-Fi gear. The group also brought power solutions such as solar cells, fuel cells, and wind turbines as...Open data kit sensors : Mobile data collection with wired and wireless sensors . Seattle, WA: Department of Computer Science and Engineering. Retrieved...activities taking place in the society. Over the years, communication has been modified from basic landlines to wireless schemes prevalent today, and

77 FR 61790 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: October 30, 2012, 10 a.m.-5:30 p.m.; October 31... science and engineering. Agenda Tuesday, October 30, 2012 Opening Statement by the CEOSE Chair...

77 FR 13367 - Advisory Committee for International Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science and Engineering; Notice... Science and Engineering (25104). Date and Time: March 19, 2012, 8:30 a.m.-5 p.m. March 20, 2012, 8:30 a.m.... Type of Meeting: Open. Contact Person: Robert Webber, Office of International Science and Engineering...

78 FR 8596 - Committee on Equal Opportunities in Science and Engineering #1173; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering 1173... Science and Engineering (CEOSE). Dates/Time: February 25, 2013, 9:00 a.m.-5:30 p.m.; February 26, 2013, 9... participation in science and engineering. Agenda: Opening Statement by the CEOSE Chair Discussions: Concurrence...

77 FR 61644 - Advisory Committee for International Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-10

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science and Engineering; Notice... Science and Engineering (25104). Date and Time: October 25, 2012 8:30 a.m.-5 p.m. October 26, 2012 8:30 a...: Open. Contact Person: Robert Webber, NSF Office of International Science and Engineering, 4201 Wilson...

75 FR 33652 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-14

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: June 29, 2010, 8:30 p.m.-5:30 p.m. June 30, 2010, 8... NSF concerning broadening participation in science and engineering. Agenda Monday, June 29, 2010...

77 FR 31893 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173) Dates/Time: June 19, 2012, 1:00 p.m.-6:00 p.m.; June 20, 2012, 9... advice and recommendations concerning broadening participation in science and engineering. Agenda Tuesday...

76 FR 55951 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: October 17, 2011, 9 a.m.-5:30 p.m. October 18, 2011... science and engineering. Agenda: Monday, Oct 17, 2011 Opening Statement by the CEOSE Chair Presentations...

75 FR 6063 - Committee on Equal Opportunities in Science and Engineering (CEOSE); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering (CEOSE... Opportunities in Science and Engineering (1173). Dates/Time: March 8, 2010, 8:30 a.m.-5:30 p.m.; March 9, 2010... concerning broadening participation in science and engineering. Agenda Primary Focus of This Meeting...

Adipose Tissue-Derived Pericytes for Cartilage Tissue Engineering.

PubMed

Zhang, Jinxin; Du, Chunyan; Guo, Weimin; Li, Pan; Liu, Shuyun; Yuan, Zhiguo; Yang, Jianhua; Sun, Xun; Yin, Heyong; Guo, Quanyi; Zhou, Chenfu

2017-01-01

Mesenchymal stem cells (MSCs) represent a promising alternative source for cartilage tissue engineering. However, MSC culture is labor-intensive, so these cells cannot be applied immediately to regenerate cartilage for clinical purposes. Risks during the ex vivo expansion of MSCs, such as infection and immunogenicity, can be a bottleneck in their use in clinical tissue engineering. As a novel stem cell source, pericytes are generally considered to be the origin of MSCs. Pericytes do not have to undergo time-consuming ex vivo expansion because they are uncultured cells. Adipose tissue is another optimal stem cell reservoir. Because adipose tissue is well vascularized, a considerable number of pericytes are located around blood vessels in this accessible and dispensable tissue, and autologous pericytes can be applied immediately for cartilage regeneration. Thus, we suggest that adipose tissue-derived pericytes are promising seed cells for cartilage regeneration. Many studies have been performed to develop isolation methods for the adipose tissuederived stromal vascular fraction (AT-SVF) using lipoaspiration and sorting pericytes from AT-SVF. These methods are useful for sorting a large number of viable pericytes for clinical therapy after being combined with automatic isolation using an SVF device and automatic magnetic-activated cell sorting. These tools should help to develop one-step surgery for repairing cartilage damage. However, the use of adipose tissue-derived pericytes as a cell source for cartilage tissue engineering has not drawn sufficient attention and preclinical studies are needed to improve cell purity, to increase sorting efficiency, and to assess safety issues of clinical applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Optimizing Chemical-Vapor-Deposition Diamond for Nitrogen-Vacancy Center Ensemble Magnetrometry

DTIC Science & Technology

2017-06-01

Ju Li Battelle Energy Alliance Professor of Nuclear Science and Engineering Professor of Materials Science and Engineering...Sciences, U. S. Air Force Academy (2015) Submitted to the Department of Nuclear Science and Engineering in partial fulfillment of the requirements for the...degree of Master of Science in Nuclear Science and Engineering at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY June 2017 c○ Massachusetts Institute of

76 FR 46769 - Applications for New Awards; Minority Science and Engineering Improvement Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... DEPARTMENT OF EDUCATION Applications for New Awards; Minority Science and Engineering Improvement... Information: Minority Science and Engineering Improvement Program (MSEIP) Notice inviting applications for new... effect long-range improvement in science and engineering education at predominantly minority institutions...

Astrobiobound! Search for Life in the Solar System: Scientists and Engineers Bringing their Challenges to K-12 Students

NASA Astrophysics Data System (ADS)

Klug Boonstra, S. L.; Swann, J.; Manfredi, L.; Zippay, A.; Boonstra, D.

2014-12-01

The Next Generation Science Standards (NGSS) brought many dynamic opportunities and capabilities to the K-12 science classroom - especially with the inclusion of engineering. Using science as a context to help students engage in the engineering practices and engineering disciplinary core ideas is an essential step to students' understanding of how science drives engineering and how engineering enables science. Real world examples and applications are critical for students to see how these disciplines are integrated. Furthermore, the interface of science and engineering raise the level of science understanding, and facilitate higher order thinking skills through relevant experiences. Astrobiobound! is designed for the NGSS (Next Generation Science Standards) and CCSS (Common Core State Standards). Students also practice and build 21st Century Skills. Astrobiobound! help students see how science and systems engineering are integrated to achieve a focused scientific goal. Students engage in the engineering design process to design a space mission which requires them to balance the return of their science data with engineering limitations such as power, mass and budget. Risk factors also play a role during this simulation and adds to the excitement and authenticity. Astrobiobound! presents the authentic first stages of NASA mission design process. This simulation mirrors the NASA process in which the science goals, type of mission, and instruments to return required data to meet mission goals are proposed within mission budget before any of the construction part of engineering can begin. NASA scientists and engineers were consulted in the development of this activity as an authentic simulation of their mission proposal process.

Programmatic Efforts Affect Retention of Women in Science and Engineering

NASA Astrophysics Data System (ADS)

Hathaway, Russel S.; Sharp, Sally; Davis, Cinda-Sue

This article presents findings from a study that investigated the impact of a women in science and engineering residence program (WISE-RP) on the retention of women in science and engineering disciplines. From a matched sample of 1,852 science and engineering students, the authors compared WISE-RP participants with male and female control students for science and engineering retention. The findings suggest a strong connection between WISE-KP participation and science retention, but not engineering retention. The results also indicate that a WISE-RP is more effective in retaining White and Asian students than underrepresented students of color. The authors highlight the importance of combining academic and personal support in a residential learning program and draw implications for retaining women т science, mathematics, and engineering disciplines.

Anticipating Change: An Exploratory Analysis of Teachers' Conceptions of Engineering in an Era of Science Education Reform

ERIC Educational Resources Information Center

Sengupta-Irving, Tesha; Mercado, Janet

2017-01-01

While integrating engineering into science education is not new in the United States, technology and engineering have not been well emphasized in the preparation and professional development of science teachers. Recent science education reforms integrate science and engineering throughout K-12 education, making it imperative to explore the…

How the Discovery Channel Television Show "Mythbusters" Accurately Depicts Science and Engineering Culture

ERIC Educational Resources Information Center

Zavrel, Erik A.

2011-01-01

High school science teachers, of course, want to motivate their students to consider studying science and engineering (S&E) in college. However, many high school students are not familiar with what science and engineering actually entail. They may know science as little more than "systematic discovery" and engineering as nothing but…

Effects of Engineering Design-Based Science on Elementary School Science Students' Engineering Identity Development across Gender and Grade

ERIC Educational Resources Information Center

Capobianco, Brenda M.; Yu, Ji H.; French, Brian F.

2015-01-01

The integration of engineering concepts and practices into elementary science education has become an emerging concern for science educators and practitioners, alike. Moreover, how children, specifically preadolescents (grades 1-5), engage in engineering design-based learning activities may help science educators and researchers learn more about…

The Science of Solubility: Using Reverse Engineering to Brew a Perfect Cup of Coffee

ERIC Educational Resources Information Center

West, Andrew B.; Sickel, Aaron J.; Cribbs, Jennifer D.

2015-01-01

The Next Generation Science Standards call for the integration of science and engineering. Often, the introduction of engineering activities occurs after instruction in the science content. That is, engineering is used as a way for students to elaborate on science ideas that have already been explored. However, using only this sequence of…

Digest of Key Science and Engineering Indicators, 2008. NSB-08-2

ERIC Educational Resources Information Center

National Science Foundation, 2008

2008-01-01

This digest of key science and engineering indicators draws primarily from the National Science Board's two-volume "Science and Engineering Indicators, 2008" report. The digest serves two purposes: (1) to draw attention to important trends and data points from across the chapters and volumes of "Science and Engineering Indicators, 2008," and (2)…

Pre-Service Science Teachers' Cognitive Structures Regarding Science, Technology, Engineering, Mathematics (STEM) and Science Education

ERIC Educational Resources Information Center

Hacioglu, Yasemin; Yamak, Havva; Kavak, Nusret

2016-01-01

The aim of this study is to reveal pre-service science teachers' cognitive structures regarding Science, Technology, Engineering, Mathematics (STEM) and science education. The study group of the study consisted of 192 pre-service science teachers. A Free Word Association Test (WAT) consisting of science, technology, engineering, mathematics and…

Emerging Perspectives in Scaffold for Tissue Engineering in Oral Surgery

PubMed Central

Presta, Rossella

2017-01-01

Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors. The biomimetic approach to create an ideal bone substitute provides strategies for developing combined scaffolds composed of adult stem cells with mesenchymal phenotype and different organic biomaterials (such as collagen and hyaluronic acid derivatives) or inorganic biomaterials such as manufactured polymers (polyglycolic acid (PGA), polylactic acid (PLA), and polycaprolactone). This review focuses on different biomaterials currently used in dentistry as scaffolds for bone regeneration in treating bone defects or in surgical techniques, such as sinus lift, horizontal and vertical bone grafts, or socket preservation. Our review would be of particular interest to medical and surgical researchers at the interface of cell biology, materials science, and tissue engineering, as well as industry-related manufacturers and researchers in healthcare, prosthetics, and 3D printing, too. PMID:28337223

Hybrid semi-parametric mathematical systems: bridging the gap between systems biology and process engineering.

PubMed

Teixeira, Ana P; Carinhas, Nuno; Dias, João M L; Cruz, Pedro; Alves, Paula M; Carrondo, Manuel J T; Oliveira, Rui

2007-12-01

Systems biology is an integrative science that aims at the global characterization of biological systems. Huge amounts of data regarding gene expression, proteins activity and metabolite concentrations are collected by designing systematic genetic or environmental perturbations. Then the challenge is to integrate such data in a global model in order to provide a global picture of the cell. The analysis of these data is largely dominated by nonparametric modelling tools. In contrast, classical bioprocess engineering has been primarily founded on first principles models, but it has systematically overlooked the details of the embedded biological system. The full complexity of biological systems is currently assumed by systems biology and this knowledge can now be taken by engineers to decide how to optimally design and operate their processes. This paper discusses possible methodologies for the integration of systems biology and bioprocess engineering with emphasis on applications involving animal cell cultures. At the mathematical systems level, the discussion is focused on hybrid semi-parametric systems as a way to bridge systems biology and bioprocess engineering.

A bird's eye view on the use of electrospun nanofibrous scaffolds for bone tissue engineering: Current state-of-the-art, emerging directions and future trends.

PubMed

Rezvani, Zahra; Venugopal, Jayarama R; Urbanska, Aleksandra M; Mills, David K; Ramakrishna, Seeram; Mozafari, Masoud

2016-10-01

Tissue engineering aims to develop therapeutic products that utilize a combination of scaffolds with viable cell systems or responsive biomolecules derived from such cells, for the repair, restoration/regeneration of tissues. Here, the main goal is to enable the body to heal itself by the introduction of electrospun scaffolds, such that the body recognizes them as its own and in turn uses them to regenerate "neo-native" functional tissues. During the last decade, innovative nanofibrous scaffolds have attracted substantial interest in bone tissue engineering. The electrospinning process makes it possible to fabricate appropriate scaffolds for bone tissue engineering from different categories of nanobiomaterials having the ability of controlled delivery of drugs in the defective tissues. It is expected that with the progress in science and technology, better bone constructs will be proposed in the future. This review discusses the innovative approaches into electrospinning techniques for the fabrication of nanofibrous scaffolds for bone tissue engineering. Copyright © 2016 Elsevier Inc. All rights reserved.

Proceedings of the 24th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Tustin, D.

1984-01-01

Progress made by the Flat-Plate Solar Array Project is described. Reports on silicon sheet growth and characterization, silicon material, process development, high-efficiency cells, environmental isolation, engineering sciences, and reliability physics are presented along with copies of visual presentations made at the 24th Project Integration Meeting.

Nanoelectronics, Nanophotonics, and Nanomagnetics: Report of the National Nanotechnology Initiative Workshop February 11-13, 2004

DTIC Science & Technology

2004-02-01

National Science and Technology Council Committee on Technology Subcommittee on Nanoscale Science, Engineering , and Technology National...18 About the Nanoscale Science, Engineering , and Technology Subcommittee The Nanoscale Science, Engineering , and Technology (NSET) Subcommittee is the...workshop was to examine trends and opportunities in nanoscale science and engineering as applied to electronic, photonic, and magnetic technologies

Recent advancements in regenerative dentistry: A review.

PubMed

Amrollahi, Pouya; Shah, Brinda; Seifi, Amir; Tayebi, Lobat

2016-12-01

Although human mouth benefits from remarkable mechanical properties, it is very susceptible to traumatic damages, exposure to microbial attacks, and congenital maladies. Since the human dentition plays a crucial role in mastication, phonation and esthetics, finding promising and more efficient strategies to reestablish its functionality in the event of disruption has been important. Dating back to antiquity, conventional dentistry has been offering evacuation, restoration, and replacement of the diseased dental tissue. However, due to the limited ability and short lifespan of traditional restorative solutions, scientists have taken advantage of current advancements in medicine to create better solutions for the oral health field and have coined it "regenerative dentistry." This new field takes advantage of the recent innovations in stem cell research, cellular and molecular biology, tissue engineering, and materials science etc. In this review, the recently known resources and approaches used for regeneration of dental and oral tissues were evaluated using the databases of Scopus and Web of Science. Scientists have used a wide range of biomaterials and scaffolds (artificial and natural), genes (with viral and non-viral vectors), stem cells (isolated from deciduous teeth, dental pulp, periodontal ligament, adipose tissue, salivary glands, and dental follicle) and growth factors (used for stimulating cell differentiation) in order to apply tissue engineering approaches to dentistry. Although they have been successful in preclinical and clinical partial regeneration of dental tissues, whole-tooth engineering still seems to be far-fetched, unless certain shortcomings are addressed. Copyright © 2016 Elsevier B.V. All rights reserved.

Researches on regenerative medicine-current state and prospect.

PubMed

Wang, Zheng-Guo; Xiao, Kai

2012-01-01

Since 1980s, the rapid development of tissue engineering and stem cell research has pushed regenerative medicine to a new fastigium, and regenerative medicine has become a noticeable research field in the international biology and medicine. In China, about 100 million patients need repair and regeneration treatment every year, while the number is much larger in the world. Regenerative medicine could provide effective salvation for these patients. Both Chinese Academy of Sciences and Chinese Academy of Engineering have made roadmaps of 2010-2050 and 2011-2030 for regenerative medicine. The final goal of the two roadmaps is to make China go up to leading position in most research aspects of regenerative medicine. In accord with this strategy, the government and some enterprises have invested 3-5 billion RMB (0.5-0.8 billion USD) for the research on regenerative medicine. In order to push the translation of regenerative medicine forward-from bench to bedside, a strategic alliance has been established, and it includes 27 top-level research institutes, medical institutes, colleges, universities and enterprises in the field of stem cell and regeneration medicine. Recently the journal, Science, has published a special issue-Regenerative Medicine in China, consisting of 35 papers dealing with stem cell and regeneration, tissue engineering and regeneration, trauma and regeneration and bases for tissue repair and regenerative medicine. It is predicated that a greater breakthrough in theory and practice of regenerative medicine will be achieved in the near future (20 to 30 years).

Arctic Science, Engineering and Education. Awards: Fiscal Years 1987 and 1988.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC.

This document summarizes the dispersal of funds on Arctic research by the National Science Foundation during fiscal years 1987 and 1988. Major areas considered were: atmospheric sciences; oceanography; biological sciences; earth sciences; science and engineering education; small business research; engineering and permafrost; Arctic information and…

Atlas 1.1: An Update to the Theory of Effective Systems Engineers

DTIC Science & Technology

2018-01-16

Proficiency Model ........................................................................................................... 21 5.1.1 Area 1: Math ... Math /Science/General Engineering: Foundational concepts from mathematics, physical sciences, and general engineering; 2. System’s Domain...Table 5. Atlas Proficiency Areas, Categories, and Topics Area Category Topic 1. Math / Science / General Engineering 1.1. Natural Science

Integrating Engineering into an Urban Science Classroom

ERIC Educational Resources Information Center

Meyer, Helen

2017-01-01

This article presents a single case study of an experienced physical science teacher (Janet) integrating engineering practices into her urban science classroom over a two-year time frame. The article traces how Janet's understanding of the role engineering in her teaching expanded beyond engineering as an application of science and mathematics to…

Students' Attitudes towards Interdisciplinary Education: A Course on Interdisciplinary Aspects of Science and Engineering Education

ERIC Educational Resources Information Center

Gero, Aharon

2017-01-01

A course entitled "Science and Engineering Education: Interdisciplinary Aspects" was designed to expose undergraduate students of science and engineering education to the attributes of interdisciplinary education which integrates science and engineering. The core of the course is an interdisciplinary lesson, which each student is…

How the Discovery Channel Television Show Mythbusters Accurately Depicts Science and Engineering Culture

NASA Astrophysics Data System (ADS)

Zavrel, Erik A.

2011-04-01

High school science teachers, of course, want to motivate their students to consider studying science and engineering (S&E) in college. However, many high school students are not familiar with what science and engineering actually entail. They may know science as little more than "systematic discovery" and engineering as nothing but "math-intensive design." Without appreciation for the rich culture of science and engineering, students will be unlikely to choose such a field of study. The Discovery Channel television show Mythbusters helps remedy the lack of understanding many people, especially young people, have about S&E. Mythbusters presents a highly accurate vignette of the culture of science and engineering. Episodes of the show were analyzed for instances in which the culture of science and engineering was accurately depicted. Many resources, including several publications of the National Research Council, informed the media analysis. To encourage more high school students to pursue S&E in college, they need to be exposed to the culture of S&E. Mythbusters provides a window into the often unseen realm of science and engineering, allowing its viewers, who are disproportionately represented among the young adult age bracket, to see what it means to conduct science and engineering on a routine basis. High school science instructors should look to Mythbusters to provide insight into the culture of S&E that textbooks often have difficulty conveying to students.

Parametric Analysis of Combustion of Porous Medium.

DTIC Science & Technology

1985-12-01

Inatituto Tecnologico de Aeronautico , 1977 Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN ENGINEERING... cell .... ............ .90 4.2 Temperature vs XIL and time for permeabilit 0.00015 ft’ initial carbon temperatiure = 70F 93 4.3 Temperature vs X/L...and permeability (m). These parameters are defined as follows. Given a unit square cell of dimension D, and particle diameter d, we have p = 1 - v

Negotiating Science and Engineering: An Exploratory Case Study of a Reform-Minded Science Teacher

ERIC Educational Resources Information Center

Guzey, S. Selcen; Ring-Whalen, Elizabeth A.

2018-01-01

Engineering has been slowly integrated into K-12 science classrooms in the United States as the result of recent science education reforms. Such changes in science teaching require that a science teacher is confident with and committed to content, practices, language, and cultures related to both science and engineering. However, from the…

Knowledge Integration and Wise Engineering

ERIC Educational Resources Information Center

Chiu, Jennifer L.; Linn, M. C.

2011-01-01

Recent efforts in engineering education focus on introducing engineering into secondary math and science courses to improve science, technology, engineering, and math (STEM) education (NAS, 2010). Infusing engineering into secondary classrooms can increase awareness of and interest in STEM careers, help students see the relevance of science and…

Life sciences and environmental sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-02-01

The DOE laboratories play a unique role in bringing multidisciplinary talents -- in biology, physics, chemistry, computer sciences, and engineering -- to bear on major problems in the life and environmental sciences. Specifically, the laboratories utilize these talents to fulfill OHER's mission of exploring and mitigating the health and environmental effects of energy use, and of developing health and medical applications of nuclear energy-related phenomena. At Lawrence Berkeley Laboratory (LBL) support of this mission is evident across the spectrum of OHER-sponsored research, especially in the broad areas of genomics, structural biology, basic cell and molecular biology, carcinogenesis, energy and environment,more » applications to biotechnology, and molecular, nuclear and radiation medicine. These research areas are briefly described.« less

Engineering Encounters: Blasting off with Engineering

ERIC Educational Resources Information Center

Dare, Emily A.; Childs, Gregory T.; Cannaday, E. Ashley; Roehrig, Gillian H

2014-01-01

What better way to engage young students in physical science concepts than to have them engineer flying toy rockets? The integration of engineering into science classrooms is advocated by the "Next Generation Science Standards" (NGSS) and researchers alike (Brophy et al. 2008), as engineering provides: (1) A "real-world…

Biomimetics in thin film design: Niche-like wrinkles designed for i-cell progenitor cell differentiation.

PubMed

Major, Roman; Lackner, Juergen M; Sanak, Marek; Major, Boguslaw

2017-11-01

The future and development of science are in interdisciplinary areas, such as biomedical engineering. Self-assembled structures, similar to stem cell niches, inhibit rapid cellular division processes and enable the capture of stem cells from blood flow. By modifying the surface topography and stiffness properties, progenitor cells were differentiated towards the formation of endothelial cell monolayers to effectively inhibit the coagulation cascade. Wrinkled material layers in the form of thin polymeric coatings were prepared. An optimized surface topography led to proper cell differentiation and influenced the appropriate formation of endothelial cell monolayers. Blood activation was decelerated by the formed endothelium. Copyright © 2017 Elsevier B.V. All rights reserved.

Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation.

PubMed

Zhang, Cui; Li, Liang; Chen, Jianling; Wang, Jinfu

2015-06-01

With rapid development of space engineering, research on life sciences in space is being conducted extensively, especially cellular and molecular studies on space medicine. Stem cells, undifferentiated cells that can differentiate into specialized cells, are considered a key resource for regenerative medicine. Research on stem cells under conditions of microgravity during a space flight or a ground-based simulation has generated several excellent findings. To help readers understand the effects of outer space and ground-based simulation conditions on stem cells, we reviewed recent studies on the effects of microgravity (as an obvious environmental factor in space) on morphology, proliferation, migration, and differentiation of stem cells. © 2015 International Federation for Cell Biology.

Foreign Science and Engineering Doctoral Attainment at American Universities

ERIC Educational Resources Information Center

Hamilton, Robert V.

2010-01-01

This dissertation analyzes the nearly 100,000 foreign students who attained science and engineering (S&E) doctorates in the five fields of physical sciences, life sciences, engineering, mathematics and computer sciences, and social and behavioral sciences at American universities from 1994 to 2005. Two models are presented. In the first model…

Scaffolds in Tendon Tissue Engineering

PubMed Central

Longo, Umile Giuseppe; Lamberti, Alfredo; Petrillo, Stefano; Maffulli, Nicola; Denaro, Vincenzo

2012-01-01

Tissue engineering techniques using novel scaffold materials offer potential alternatives for managing tendon disorders. Tissue engineering strategies to improve tendon repair healing include the use of scaffolds, growth factors, cell seeding, or a combination of these approaches. Scaffolds have been the most common strategy investigated to date. Available scaffolds for tendon repair include both biological scaffolds, obtained from mammalian tissues, and synthetic scaffolds, manufactured from chemical compounds. Preliminary studies support the idea that scaffolds can provide an alternative for tendon augmentation with an enormous therapeutic potential. However, available data are lacking to allow definitive conclusion on the use of scaffolds for tendon augmentation. We review the current basic science and clinical understanding in the field of scaffolds and tissue engineering for tendon repair. PMID:22190961

Overview of the Microgravity Science Glovebox (MSG)

NASA Technical Reports Server (NTRS)

Wright, Mary Etta

1999-01-01

MSG is a third generation glovebox for Microgravity Science investigations: SpaceLab Glovebox (GBX); Middeck/MIR Gloveboxes (M/MGBX); and GBX and M/MGBX developed by Bradford Engineering (NL). Previous flights have demonstrated utility of glovebox facilities: Contained environment enables broader range of science experiments; Affords better control of video and photographic imaging (a prime data source); Provides better environmental control than cabin atmosphere; and Useful for contingency operations. MSG developed in response to demands for increased work volume, increased capabilities and additional resources. MSG is multi-user facility to support a wide range of small science and technology investigations: Fluid physics; Combustion science; Material science; Biotechnology (cell culturing and protein crystal growth); Space processing; Fundamental physics; and Technology demonstrations. Topics included in this viewgraph are: MSG capabilities; MSG hardware items; MSG, GSE, and OSE items; MSG development approach; and Science utilization.

75 FR 9000 - Comment Request: National Science Foundation Proposal/Award Information-Grant Proposal Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... process; Programs to strengthen scientific and engineering research potential; Science and engineering..., authority to support applied research was added to the Organic Act. In 1980, The Science and Engineering... NATIONAL SCIENCE FOUNDATION Comment Request: National Science Foundation Proposal/Award...

77 FR 13159 - Nanoscale Science, Engineering, and Technology Subcommittee of the Committee on Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee of the Committee on Technology, National Science and Technology Council Workshop ACTION: Notice of... Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the Committee on Technology, National...

Building Alaska's Science and Engineering Pipeline: Evaluation of the Alaska Native Science & Engineering Program

ERIC Educational Resources Information Center

Bernstein, Hamutal; Martin, Carlos; Eyster, Lauren; Anderson, Theresa; Owen, Stephanie; Martin-Caughey, Amanda

2015-01-01

The Urban Institute conducted an implementation and participant-outcomes evaluation of the Alaska Native Science & Engineering Program (ANSEP). ANSEP is a multi-stage initiative designed to prepare and support Alaska Native students from middle school through graduate school to succeed in science, technology, engineering, and math (STEM)…

Studying Science and Engineering Learning in Practice

ERIC Educational Resources Information Center

Penuel, William R.

2016-01-01

A key goal of science and engineering education is to provide opportunities for people to access, interpret, and make use of science and engineering to address practical human needs. Most education research, however, focuses on how best to prepare students in schools to participate in forms of science and engineering practices that resemble those…

Committee on Women in Science, Engineering, and Medicine (CWSEM)

Science.gov Websites

Skip to Main Content Contact Us | Search: Search The National Academies of Sciences, Engineering and Medicine Committee on Women in Science, Engineering, and Medicine Committee on Women in Science , Engineering, and Medicine Policy and Global Affairs Home About Us Members Subscribe to CWSEM Alerts Resources

76 FR 20051 - Advisory Committee for International Science & Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science & Engineering; Notice of... Engineering ( 25104). Date/Time: April 25, 2011; 8:30 a.m. to 5 p.m. April 26, 2011; 8:30 a.m. to 12 p.m... International Science and Engineering, Reports from Advisory Committee Working Groups. April 26, 2011 AM...

75 FR 13313 - Advisory Committee for International Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science and Engineering; Notice... Science and Engineering ( 25104). Date/Time: April 19, 2010--8:30 a.m. to 5 p.m. April 20, 2010--8:30 a.m... Engineering. Agenda April 19, 2010 AM: Introductions and Updates--Presentation and Discussion of 2010...

78 FR 32475 - Committee on Equal Opportunities in Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering; Notice of... Engineering (CEOSE) Advisory Committee Meeting, 1173. Dates/Time: June 19, 2013, 9:00 a.m.-5:30 p.m. June 20... participation in science and engineering. Agenda: Opening Statement by the CEOSE Chair [[Page 32476...

75 FR 52996 - Advisory Committee for International Science & Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science & Engineering; Notice of... Engineering ( 25104). Date/Time: September 20, 2010; 9 a.m. to 5:15 p.m.; September 21, 2009; 8:30 a.m. to 12..., education and related activities involving U.S. science and engineering working within a global context, as...

Site Characterization Report (Building 202). Volume 2. Appendicies A-H.

DTIC Science & Technology

1996-04-01

Bionetics,Groundwater and Wells, Environmental Science and Engineering, Inc., Installation Assessment of ERADCOM Activities, Environmental Science and...Engineering, Inc., Plan for the Assessment of Contamination at Woodbridge Research Facility, Environmental Science and Engineering, Inc., Remedial...Action Plan for the Woodbridge Research Facility PCB Disposal Site, Environmental Science and Engineering, Inc., Remedial Investigation and

Resource Materials for Nanoscale Science and Technology Education

NASA Astrophysics Data System (ADS)

Lisensky, George

2006-12-01

Nanotechnology and advanced materials examples can be used to explore science and engineering concepts, exhibiting the "wow" and potential of nanotechnology, introducing prospective scientists to key ideas, and educating a citizenry capable of making well-informed technology-driven decisions. For example, material syntheses an atomic layer at a time have already revolutionized lighting and display technologies and dramatically expanded hard drive storage capacities. Resource materials include kits, models, and demonstrations that explain scanning probe microscopy, x-ray diffraction, information storage, energy and light, carbon nanotubes, and solid-state structures. An online Video Lab Manual, where movies show each step of the experiment, illustrates more than a dozen laboratory experiments involving nanoscale science and technology. Examples that are useful at a variety of levels when instructors provide the context include preparation of self-assembled monolayers, liquid crystals, colloidal gold, ferrofluid nanoparticles, nickel nanowires, solar cells, electrochromic thin films, organic light emitting diodes, and quantum dots. These resources have been developed, refined and class tested at institutions working with the Materials Research Science and Engineering Center on Nanostructured Interfaces at the University of Wisconsin-Madison (http://mrsec.wisc.edu/nano).

Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.

PubMed

Keu, Khun Visith; Witney, Timothy H; Yaghoubi, Shahriar; Rosenberg, Jarrett; Kurien, Anita; Magnusson, Rachel; Williams, John; Habte, Frezghi; Wagner, Jamie R; Forman, Stephen; Brown, Christine; Allen-Auerbach, Martin; Czernin, Johannes; Tang, Winson; Jensen, Michael C; Badie, Behnam; Gambhir, Sanjiv S

2017-01-18

High-grade gliomas are aggressive cancers that often become rapidly fatal. Immunotherapy using CD8 + cytotoxic T lymphocytes (CTLs), engineered to express both herpes simplex virus type 1 thymidine kinase (HSV1-TK) and interleukin-13 (IL-13) zetakine chimeric antigen receptor (CAR), is a treatment strategy with considerable potential. To optimize this and related immunotherapies, it would be helpful to monitor CTL viability and trafficking to glioma cells. We show that noninvasive positron emission tomography (PET) imaging with 9-[4-[ 18 F]fluoro-3-(hydroxymethyl)butyl]guanine ([ 18 F]FHBG) can track HSV1-tk reporter gene expression present in CAR-engineered CTLs. [ 18 F]FHBG imaging was safe and enabled the longitudinal imaging of T cells stably transfected with a PET reporter gene in patients. Further optimization of this imaging approach for monitoring in vivo cell trafficking should greatly benefit various cell-based therapies for cancer. Copyright © 2017, American Association for the Advancement of Science.

An engineer at AeroVironment's Design Development Center inspects a set of silicon solar cells for p

NASA Technical Reports Server (NTRS)

2000-01-01

An engineer at AeroVironment's Design Development Center in Simi Valley, California, closely inspects a set of silicon solar cells for potential defects. The cells, fabricated by SunPower, Inc., of Sunnyvale, California, are among 64,000 solar cells which have been installed on the Helios Prototype solar-powered aircraft to provide power to its 14 electric motors and operating systems. Developed by AeroVironment under NASA's Environmental Research Aircraft and Sensor Technology (ERAST) project, the Helios Prototype is the forerunner of a planned fleet of slow-flying, long duration, high-altitude aircraft which can perform atmospheric science missions and serve as telecommunications relay platforms in the stratosphere. Target goals set by NASA for the giant 246-foot span flying wing include reaching and sustaining subsonic horizontal flight at 100,000 feet altitude in 2001, and sustained continuous flight for at least four days and nights in 2003 with the aid of a regenerative fuel cell-based energy storage system now in development.

Math, Science, and Engineering Integration in a High School Engineering Course: A Qualitative Study

ERIC Educational Resources Information Center

Valtorta, Clara G.; Berland, Leema K.

2015-01-01

Engineering in K-12 classrooms has been receiving expanding emphasis in the United States. The integration of science, mathematics, and engineering is a benefit and goal of K-12 engineering; however, current empirical research on the efficacy of K-12 science, mathematics, and engineering integration is limited. This study adds to this growing…

Analysing the Integration of Engineering in Science Lessons with the Engineering-Infused Lesson Rubric

ERIC Educational Resources Information Center

Peterman, Karen; Daugherty, Jenny L.; Custer, Rodney L.; Ross, Julia M.

2017-01-01

Science teachers are being called on to incorporate engineering practices into their classrooms. This study explores whether the Engineering-Infused Lesson Rubric, a new rubric designed to target best practices in engineering education, could be used to evaluate the extent to which engineering is infused into online science lessons. Eighty lessons…

Pre-Engineering Program: Science, Technology, Engineering and Mathematics (STEM)

DTIC Science & Technology

2013-08-29

educators in the Urbana-Champaign area. 15. SUBJECT TERMS STEM: science, technology , engineering, mathematics 16. SECURITY CLASSIFICATION OF: 19a. NAME...9132T-13-1-0002 4. TITLE AND SUBTITLE Pre-Engineering Program: Science, Technology , Engineering and Mathematics (STEM) 5c. PROGRAM ELEMENT NUMBER N...project was focused on underserved children in grades 1-6 who need, but have limited access to, out-of-school time STEM (science, technology

Tissue engineering as innovative chance for organ replacement in radical tumor surgery.

PubMed

Alberti, C

2013-03-01

Different pathological conditions such as congenital organ absence, severe organ injuries, end-stage organ failure and malignancy-related organ removal, have few effective therapeutic options a part from a whole organ transplant, that, however, often meets with a serious shortage of suitable donor organs. The purpose of this paper consists in highlighting what the novel tissue engineering approaches might help to solve such problems. EMERGING CONCEPTS: A recent approach in tissue/organ engineering, particularly to build bioartificial airways, is the procedure of decellularizing a whole donor organ to obtain a complex 3D-biomatrix-scaffold maintaining the intrinsic vascular network, that is subsequently recellularized with recipient's autologous organ-specific differentiated cells or/and stem cells, to build a potentially functional biological substitute. Such strategy has been clinically used to replace organ in trachea/broncus tumor patients. In another approach, mainly used to construct a bioartificial urinary bladder tissue, different types of either biodegradable synthetic polymers or naturally-derived matrices or even polymer/biomatrix-composite materials are used as scaffold for either cell-free or autologous cell-seeded tissue engineering procedures. So far, such technique has been mainly used to make an augmentation cystoplasty in patients with end-stage poorly compliant neuropathic bladder or in exstrophic bladder subjects. Intriguing developments in biomaterial science, nanotechnologies, stem cell biology, and further improvements in bioreactor manufacturing will allow to generate, in the near future, tissue engineered organs that, as for structure/function so the native one-like, might represent the optimum solution to replace organs in tumor surgery.

Engineering Encounters: An Engineering Design Process for Early Childhood

ERIC Educational Resources Information Center

Lottero-Perdue, Pamela; Bowditch, Michelle; Kagan, Michelle; Robinson-Cheek, Linda; Webb, Tedra; Meller, Megan; Nosek, Theresa

2016-01-01

This column presents ideas and techniques to enhance your science teaching. This month's issue shares information about trying (again) to engineer an egg package. Engineering is an essential part of science education, as emphasized in the "Next Generation Science Standards" (NGSS Lead States 2013). Engineering practices and performance…

Engineering Design Skills Coverage in K-12 Engineering Program Curriculum Materials in the USA

ERIC Educational Resources Information Center

Chabalengula, Vivien M.; Mumba, Frackson

2017-01-01

The current "K-12 Science Education framework" and "Next Generation Science Standards" (NGSS) in the United States emphasise the integration of engineering design in science instruction to promote scientific literacy and engineering design skills among students. As such, many engineering education programmes have developed…

Differentiating between Women in Hard and Soft Science and Engineering Disciplines

ERIC Educational Resources Information Center

Camp, Amanda G.; Gilleland, Diane S.; Pearson, Carolyn; Vander Putten, James

2010-01-01

The intent of this study was to investigate characteristics that differentiate between women in soft (social, psychological, and life sciences) and hard (engineering, mathematics, computer science, physical science) science and engineering disciplines. Using the Beginning Postsecondary Students Longitudinal Study: 1996-2001 (2002), a descriptive…

76 FR 4947 - Comment Request: National Science Foundation Proposal & Award Policies and Procedures Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... process; Programs to strengthen scientific and engineering research potential; Science and engineering..., authority to support applied research was added to the Organic Act. In 1980, The Science and Engineering... NATIONAL SCIENCE FOUNDATION Comment Request: National Science Foundation Proposal & Award Policies...

Formative Assessment Probes: Pendulums and Crooked Swings--Connecting Science and Engineering

ERIC Educational Resources Information Center

Keeley, Page

2013-01-01

The "Next Generation Science Standards" provide opportunities for students to experience the link between science and engineering. In the December 2011 issue of "Science and Children," Rodger Bybee explains: "The relationship between science and engineering practices is one of complementarity. Given the inclusion of…

Returning to the Moon: Building the Systems Engineering Base for Successful Science Missions

NASA Astrophysics Data System (ADS)

Eppler, D.; Young, K.; Bleacher, J.; Klaus, K.; Barker, D.; Evans, C.; Tewksbury, B.; Schmitt, H.; Hurtado, J.; Deans, M.; Yingst, A.; Spudis, P.; Bell, E.; Skinner, J.; Cohen, B.; Head, J.

2018-04-01

Enabling science return on future lunar missions will require coordination between the science community, design engineers, and mission operators. Our chapter is based on developing science-based systems engineering and operations requirements.

Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain

PubMed Central

Florea, Michael; Hagemann, Henrik; Santosa, Gabriella; Micklem, Chris N.; Spencer-Milnes, Xenia; de Arroyo Garcia, Laura; Paschou, Despoina; Lazenbatt, Christopher; Kong, Deze; Chughtai, Haroon; Jensen, Kirsten; Freemont, Paul S.; Kitney, Richard; Reeve, Benjamin; Ellis, Tom

2016-01-01

Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae. Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of Komagataeibacter rhaeticus (K. rhaeticus iGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achieved external control over its bacterial cellulose production through development of a modular genetic toolkit that enables rational reprogramming of the cell. To further its use as an organism for biotechnology, we sequenced its genome and demonstrate genetic circuits that enable functionalization and patterning of heterologous gene expression within the cellulose matrix. This work lays the foundations for using genetic engineering to produce cellulose-based materials, with numerous applications in basic science, materials engineering, and biotechnology. PMID:27247386

Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain.

PubMed

Florea, Michael; Hagemann, Henrik; Santosa, Gabriella; Abbott, James; Micklem, Chris N; Spencer-Milnes, Xenia; de Arroyo Garcia, Laura; Paschou, Despoina; Lazenbatt, Christopher; Kong, Deze; Chughtai, Haroon; Jensen, Kirsten; Freemont, Paul S; Kitney, Richard; Reeve, Benjamin; Ellis, Tom

2016-06-14

Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of Komagataeibacter rhaeticus (K. rhaeticus iGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achieved external control over its bacterial cellulose production through development of a modular genetic toolkit that enables rational reprogramming of the cell. To further its use as an organism for biotechnology, we sequenced its genome and demonstrate genetic circuits that enable functionalization and patterning of heterologous gene expression within the cellulose matrix. This work lays the foundations for using genetic engineering to produce cellulose-based materials, with numerous applications in basic science, materials engineering, and biotechnology.

Developing the Next Generation of Science Data System Engineers

NASA Technical Reports Server (NTRS)

Moses, John F.; Behnke, Jeanne; Durachka, Christopher D.

2016-01-01

At Goddard, engineers and scientists with a range of experience in science data systems are needed to employ new technologies and develop advances in capabilities for supporting new Earth and Space science research. Engineers with extensive experience in science data, software engineering and computer-information architectures are needed to lead and perform these activities. The increasing types and complexity of instrument data and emerging computer technologies coupled with the current shortage of computer engineers with backgrounds in science has led the need to develop a career path for science data systems engineers and architects.The current career path, in which undergraduate students studying various disciplines such as Computer Engineering or Physical Scientist, generally begins with serving on a development team in any of the disciplines where they can work in depth on existing Goddard data systems or serve with a specific NASA science team. There they begin to understand the data, infuse technologies, and begin to know the architectures of science data systems. From here the typical career involves peermentoring, on-the-job training or graduate level studies in analytics, computational science and applied science and mathematics. At the most senior level, engineers become subject matter experts and system architect experts, leading discipline-specific data centers and large software development projects. They are recognized as a subject matter expert in a science domain, they have project management expertise, lead standards efforts and lead international projects. A long career development remains necessary not only because of the breadth of knowledge required across physical sciences and engineering disciplines, but also because of the diversity of instrument data being developed today both by NASA and international partner agencies and because multidiscipline science and practitioner communities expect to have access to all types of observational data.This paper describes an approach to defining career-path guidance for college-bound high school and undergraduate engineering students, junior and senior engineers from various disciplines.

Developing the Next Generation of Science Data System Engineers

NASA Astrophysics Data System (ADS)

Moses, J. F.; Durachka, C. D.; Behnke, J.

2015-12-01

At Goddard, engineers and scientists with a range of experience in science data systems are needed to employ new technologies and develop advances in capabilities for supporting new Earth and Space science research. Engineers with extensive experience in science data, software engineering and computer-information architectures are needed to lead and perform these activities. The increasing types and complexity of instrument data and emerging computer technologies coupled with the current shortage of computer engineers with backgrounds in science has led the need to develop a career path for science data systems engineers and architects. The current career path, in which undergraduate students studying various disciplines such as Computer Engineering or Physical Scientist, generally begins with serving on a development team in any of the disciplines where they can work in depth on existing Goddard data systems or serve with a specific NASA science team. There they begin to understand the data, infuse technologies, and begin to know the architectures of science data systems. From here the typical career involves peer mentoring, on-the-job training or graduate level studies in analytics, computational science and applied science and mathematics. At the most senior level, engineers become subject matter experts and system architect experts, leading discipline-specific data centers and large software development projects. They are recognized as a subject matter expert in a science domain, they have project management expertise, lead standards efforts and lead international projects. A long career development remains necessary not only because of the breath of knowledge required across physical sciences and engineering disciplines, but also because of the diversity of instrument data being developed today both by NASA and international partner agencies and because multi-discipline science and practitioner communities expect to have access to all types of observational data. This paper describes an approach to defining career-path guidance for college-bound high school and undergraduate engineering students, junior and senior engineers from various disciplines.

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Visitors crowd the NASA exhibits during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, on the National Mall in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Visitors to the USA Science and Engineering Festival look over the many exhibits, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

The Impact of Design-Based STEM Integration Curricula on Student Achievement in Engineering, Science, and Mathematics

ERIC Educational Resources Information Center

Selcen Guzey, S.; Harwell, Michael; Moreno, Mario; Peralta, Yadira; Moore, Tamara J.

2017-01-01

The new science education reform documents call for integration of engineering into K-12 science classes. Engineering design and practices are new to most science teachers, meaning that implementing effective engineering instruction is likely to be challenging. This quasi-experimental study explored the influence of teacher-developed, engineering…

77 FR 24538 - Advisory Committee for Computer and Information Science And Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... Engineering; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as... Computer and Information Science and Engineering (1115). Date and Time: May 10, 2012 12 p.m.-5:30 p.m., May... Science and Engineering, National Science Foundation, 4201 Wilson Blvd., Suite 1105, Arlington VA 22230...

76 FR 61118 - Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-03

... Engineering; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as... Computer and Information Science and Engineering (1115). Date and Time: November 1, 2011 from 12 p.m.-5:30... Computer and Information Science and Engineering, National Science Foundation, 4201 Wilson Blvd., Suite...

Examining Elementary School Students' Mental Models of Sun-Earth Relationships as a Result of Engaging in Engineering Design

ERIC Educational Resources Information Center

Dankenbring, Chelsey; Capobianco, Brenda M.

2016-01-01

Current reform efforts in science education in the United States call for students to learn science through the integration of science and engineering practices. Studies have examined the effect of engineering design on students' understanding of engineering, technology, and science concepts. However, the majority of studies emphasize the accuracy…

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Participants look through telescopes to observe the Sun during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

Associations and Committees of or for Women in Science, Engineering, Mathematics and Medicine.

ERIC Educational Resources Information Center

Aldrich, Michele, Comp.; Leach, Alicia, Comp.

Provided is a list of associations and committees of or for women in science, engineering, mathematics, and medicine. The list is organized by discipline, with cross-referencing to cognate specialties. The disciplines include: anthropology; astronomy; atmospheric sciences; biology; chemistry; computer sciences; earth sciences; energy; engineering;…

Brains--Computers--Machines: Neural Engineering in Science Classrooms

ERIC Educational Resources Information Center

Chudler, Eric H.; Bergsman, Kristen Clapper

2016-01-01

Neural engineering is an emerging field of high relevance to students, teachers, and the general public. This feature presents online resources that educators and scientists can use to introduce students to neural engineering and to integrate core ideas from the life sciences, physical sciences, social sciences, computer science, and engineering…

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges.

PubMed

Kumar, Vivek A; Brewster, Luke P; Caves, Jeffrey M; Chaikof, Elliot L

2011-09-01

Vascular disease results in the decreased utility and decreased availability of autologus vascular tissue for small diameter (< 6 mm) vessel replacements. While synthetic polymer alternatives to date have failed to meet the performance of autogenous conduits, tissue-engineered replacement vessels represent an ideal solution to this clinical problem. Ongoing progress requires combined approaches from biomaterials science, cell biology, and translational medicine to develop feasible solutions with the requisite mechanical support, a non-fouling surface for blood flow, and tissue regeneration. Over the past two decades interest in blood vessel tissue engineering has soared on a global scale, resulting in the first clinical implants of multiple technologies, steady progress with several other systems, and critical lessons-learned. This review will highlight the current inadequacies of autologus and synthetic grafts, the engineering requirements for implantation of tissue-engineered grafts, and the current status of tissue-engineered blood vessel research.

Cardiac tissue engineering: state of the art.

PubMed

Hirt, Marc N; Hansen, Arne; Eschenhagen, Thomas

2014-01-17

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for the past decade. Profound advances in human stem cell biology and technology, tissue engineering and material sciences, as well as prevascularization and in vitro assay technologies make the first clinical application of engineered cardiac tissues a realistic option and predict that cardiac tissue engineering techniques will find widespread use in the preclinical research and drug development in the near future. Tasks that need to be solved for this purpose include standardization of human myocyte production protocols, establishment of simple methods for the in vitro vascularization of 3D constructs and better maturation of myocytes, and, finally, thorough definition of the predictive value of these methods for preclinical safety pharmacology. The present article gives an overview of the present state of the art, bottlenecks, and perspectives of cardiac tissue engineering for cardiac repair and in vitro testing.

Women in science & engineering and minority engineering scholarships : year 5.

DOT National Transportation Integrated Search

2011-06-01

Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...

Women in science & engineering and minority engineering scholarships : year 4.

DOT National Transportation Integrated Search

2010-04-01

Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...

An Online, Interactive Renewable Energy Laboratory

ERIC Educational Resources Information Center

O'Leary, D. A.; Shattuck, J.; Kubby, J.

2012-01-01

An undergraduate introductory science, technology, engineering, and math (STEM) class can be a jarring disappointment to new students expecting to work with cutting-edge, real-world technology. Their cell phones are often more technically advanced and real-world than the tools used in a class lab. Not surprisingly, many complain that the STEM labs…

Flat Plate Solar Array Project: Proceedings of the 20th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1982-01-01

Progress made by the Flat-Plate Solar Array Project during the period November 1981 to April 1982 is reported. Project analysis and integration, technology research in silicon material, large-area silicon sheet and environmental isolation, cell and module formation, engineering sciences, and module performance and failure analysis are covered.

Engineering Education: A Clear Decision

ERIC Educational Resources Information Center

Strimel, Greg J.; Grubbs, Michael E.; Wells, John G.

2017-01-01

The core subjects in P-12 education have a common key characteristic that makes them stable over time. That characteristic is a steady content. For example, in the sciences, the basics of biology remain the same--the cell is the basic building block around which organisms are defined, characterized, structured, etc. Similarly, the basics of…

34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Engineering Improvement Program? 637.4 Section 637.4 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering... American origin), Pacific Islander or other ethnic group underrepresented in science and engineering...

34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Engineering Improvement Program? 637.4 Section 637.4 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering... American origin), Pacific Islander or other ethnic group underrepresented in science and engineering...

34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Engineering Improvement Program? 637.4 Section 637.4 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering... American origin), Pacific Islander or other ethnic group underrepresented in science and engineering...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Engineering Improvement Program? 637.4 Section 637.4 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering... American origin), Pacific Islander or other ethnic group underrepresented in science and engineering...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Engineering Improvement Program? 637.4 Section 637.4 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering... American origin), Pacific Islander or other ethnic group underrepresented in science and engineering...

Environmental Science and Engineering Merit Badges: An Exploratory Case Study of a Non-Formal Science Education Program and the U.S. Scientific and Engineering Practices

ERIC Educational Resources Information Center

Vick, Matthew E.; Garvey, Michael P.

2016-01-01

The Boy Scouts of America's Environmental Science and Engineering merit badges are two of their over 120 merit badges offered as a part of a non-formal educational program to U.S. boys. The Scientific and Engineering Practices of the U.S. Next Generation Science Standards provide a vision of science education that includes integrating eight…

Considering Student Voices: Examining the Experiences of Underrepresented Students in Intervention Programs.

PubMed

Gibau, Gina Sanchez

2015-01-01

Qualitative studies that examine the experiences of underrepresented minority students in science, technology, engineering, and mathematics fields are comparatively few. This study explores the self-reported experiences of underrepresented graduate students in the biomedical sciences of a large, midwestern, urban university. Document analysis of interview transcripts from program evaluations capture firsthand accounts of student experiences and reveal the need for a critical examination of current intervention programs designed to reverse the trend of underrepresentation in the biomedical sciences. Findings point to themes aligned around the benefits and challenges of program components, issues of social adjustment, the utility of supportive relationships, and environmental impacts. © 2015 G. S. Gibau. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

FY 1999 Laboratory Directed Research and Development annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

PJ Hughes

2000-06-13

A short synopsis of each project is given covering the following main areas of research and development: Atmospheric sciences; Biotechnology; Chemical and instrumentation analysis; Computer and information science; Design and manufacture engineering; Ecological science; Electronics and sensors; Experimental technology; Health protection and dosimetry; Hydrologic and geologic science; Marine sciences; Materials science; Nuclear science and engineering; Process science and engineering; Sociotechnical systems analysis; Statistics and applied mathematics; and Thermal and energy systems.

Multijunction Solar Cell Efficiencies: Effect of Spectral Window, Optical Environment and Radiative Coupling

DTIC Science & Technology

2014-09-04

Multijunction solar cell efficiencies: effect of spectral window, optical environment and radiative coupling† Carissa N. Eisler ,a Ze’ev R. Abrams,b...SC0001293. C. N. Eisler was supported by the Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG...Photovoltaic Specialists Conference, Tampa, FL, 2013. 20 E. M. Ellion, World Pat., 8,701,512, 1987 . 21 B. Mitchell, G. Peharz, G. Siefer, M. Peters, T

Argonne Chemical Sciences & Engineering - Awards Home

Science.gov Websites

Argonne National Laboratory Chemical Sciences & Engineering DOE Logo CSE Home About CSE Argonne Home > Chemical Sciences & Engineering > Fundamental Interactions Catalysis & Energy Computational Postdoctoral Fellowships Contact Us CSE Intranet Awards Argonne's Chemical Sciences and

The Nexus between Science Literacy & Technical Literacy: A State by State Analysis of Engineering Content in State Science Standards

ERIC Educational Resources Information Center

Koehler, Catherine M.; Faraclas, Elias; Giblin, David; Moss, David M.; Kazerounian, Kazem

2013-01-01

This study explores how engineering concepts are represented in secondary science standards across the nation by examining how engineering and technical concepts are infused into these frameworks. Secondary science standards from 49 states plus the District of Columbia were analyzed and ranked based on how many engineering concepts were found.…

Engineering Science--Raising Awareness of Engineering through Key Stage 3 (Age 11-14) Science

ERIC Educational Resources Information Center

Mannion, Ken

2012-01-01

During 2011, a team from the Centre for Science Education (CSE) worked with four local schools and five Sheffield city region engineering organisations on a project to identify ways to increase the input into young people's awareness of engineering that comes from activities they do in school science. The project also tested an hypothesis that…

76 FR 31642 - Committee on Equal Opportunities in Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering; Notice of... Engineering (1173). Dates/Time: June 13, 2011, 9 a.m.-4:30 p.m. June 14, 2011, 9 a.m.-2 p.m. Places: June 13... participation in science and engineering. Agenda Monday, June 13, 2011 Opening Statement by the CEOSE Chair...

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Visitors to the USA Science and Engineering Festival look on at one of the many exhibits, Saturday, Oct. 23, 2010, on the National Mall in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Children react as a tiny Mars Rover rolls over their backs at the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

The founding of ISOTT: the Shamattawa of engineering science and medical science.

PubMed

Bruley, Duane F

2014-01-01

The founding of ISOTT was based upon the blending of Medical and Engineering sciences. This occurrence is portrayed by the Shamattawa, the joining of the Chippewa and Flambeau rivers. Beginning with Carl Scheele's discovery of oxygen, the medical sciences advanced the knowledge of its importance to physiological phenomena. Meanwhile, engineering science was evolving as a mathematical discipline used to define systems quantitatively from basic principles. In particular, Adolf Fick's employment of a gradient led to the formalization of transport phenomena. These two rivers of knowledge were blended to found ISOTT at Clemson/Charleston, South Carolina, USA, in 1973.The establishment of our society with a mission to support the collaborative work of medical scientists, clinicians and all disciplines of engineering was a supporting step in the evolution of bioengineering. Traditional engineers typically worked in areas not requiring knowledge of biology or the life sciences. By encouraging collaboration between medical science and traditional engineering, our society became one of the forerunners in establishing bioengineering as the fifth traditional discipline of engineering.

Negotiating science and engineering: an exploratory case study of a reform-minded science teacher

NASA Astrophysics Data System (ADS)

Guzey, S. Selcen; Ring-Whalen, Elizabeth A.

2018-05-01

Engineering has been slowly integrated into K-12 science classrooms in the United States as the result of recent science education reforms. Such changes in science teaching require that a science teacher is confident with and committed to content, practices, language, and cultures related to both science and engineering. However, from the perspective of the science teacher, this would require not only the development of knowledge and pedagogies associated with engineering, but also the construction of new identities operating within the reforms and within the context of their school. In this study, a middle school science teacher was observed and interviewed over a period of nine months to explore his experiences as he adopted new values, discourses, and practices and constructed his identity as a reform-minded science teacher. Our findings revealed that, as the teacher attempted to become a reform-minded science teacher, he constantly negotiated his professional identities - a dynamic process that created conflicts in his classroom practices. Several differences were observed between the teacher's science and engineering instruction: hands-on activities, depth and detail of content, language use, and the way the teacher positioned himself and his students with respect to science and engineering. Implications for science teacher professional development are discussed.

Rationally engineering natural protein assemblies in nanobiotechnology.

PubMed

Howorka, Stefan

2011-08-01

Multimeric protein assemblies are essential components in viruses, bacteria, eukaryotic cells, and organisms where they act as cytoskeletal scaffold, storage containers, or for directional transport. The bottom-up structures can be exploited in nanobiotechnology by harnessing their built-in properties and combining them with new functional modules. This review summarizes the design principles of natural protein assemblies, highlights recent progress in their structural elucidation, and shows how rational engineering can create new biomaterials for applications in vaccine development, biocatalysis, materials science, and synthetic biology. Copyright © 2011 Elsevier Ltd. All rights reserved.

Gene therapy with growth factors for periodontal tissue engineering–A review

PubMed Central

Gupta, Shipra; Mahendra, Aneet

2012-01-01

The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. A challenge faced by periodontal therapy is the predictable regeneration of periodontal tissues lost as a consequence of disease. Growth factors are critical to the development, maturation, maintenance and repair of oral tissues as they establish an extra-cellular environment that is conducive to cell and tissue growth. Tissue engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. The aim of this paper is to review emerging periodontal therapies in the areas of materials science, growth factor biology and cell/gene therapy. Various such materials have been formulated into devices that can be used as vehicles for delivery of cells, growth factors and DNA. Different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral and tooth supporting structure. Key words: Periodontal disease, gene therapy, regeneration, tissue repair, growth factors, tissue engineering. PMID:22143705

A study of the historical role of African Americans in science, engineering and technology

NASA Astrophysics Data System (ADS)

Jones, Keith Wayne

2000-11-01

The purpose of this study was to determine if there is adequate documentation of an historical role of African and African American involvement in science, engineering, and technology. Through the use of history of science and technology research methodology, along with an examination of the sociological and economic impacts of adequately accredited innovations and inventions contributed by Africans and African Americans, the researcher investigated their contributions to the following areas of science and technology: life science, physical sciences and chemistry, engineering, and science education. In regard to the timeframe for this study, the researcher specifically investigated African and African American involvement in science and technology that includes periods prior to black enslavement, scientific racism and colonialism, as well as during and after those periods. This research study reveals that there are adequate historical data regarding African and African American contributions to science, engineering, and technology. The data reveals that for many millennia African peoples have been continually involved in science and world science histories. The data further show that the numbers of African Americans acquiring BS, MS, Ph.D., Doctor of Science and Doctor of Engineering degrees in science and engineering disciplines are increasing. That these increases are not happening at a rate representative of the present or future African American percentages of the population. Consequently, because of future changes in our nation's demographics, increasing the numbers of people from under-represented groups who pursue scientific and engineering professions has become a matter of national security at the highest levels of government. Moreover, African Americans, Hispanics, and Native Americans are not pursuing careers or taking courses in science and engineering at a rate high enough to fulfill the prospective needs for the United States' industries, government, and military. Projections are that, in the 21st century, there will be even greater needs for more scientists, engineers, information technologists, and other types of scientific workers. The data from this study indicate that more inclusive history of science and technology can be used as a means for encouraging more people from under-represented groups to become scientifically literate and to pursue science and engineering careers.

AMTD: Update of Engineering Specifications Derived from Science Requirements for Future UVOIR Space Telescopes

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2014-01-01

AMTD is using a Science Driven Systems Engineering approach to develop Engineering Specifications based on Science Measurement Requirements and Implementation Constraints. Science requirements meet the needs of both Exoplanet and General Astrophysics science. Engineering Specifications are guiding our effort to mature to TRL-6 the critical technologies needed to produce 4-m or larger flight-qualified UVOIR mirrors by 2018 so that a viable mission can be considered by the 2020 Decadal Review.

In-vitro Cell Exposure Studies for the Assessment of Nanoparticle Toxicity in the Lung - A Dialogue between Aerosol Science and Biology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanns-Rudolf, Paur; Cassee, Flemming R.; Teeguarden, Justin G.

The rapid introduction of engineered nanostructured materials into numerous industrial and consumer products will result in enhanced exposure to engineered nanoparticles. Workplace exposure has been identified as the most likely source of uncontrolled inhalation of engineered aerosolized nanoparticles, but release of engineered nanoparticles may occur at any stage of the lifecycle of consumer products. The dynamic development of new nanomaterials with possibly unknown toxicological effects poses a challenge for the assessment of nanoparticle induced toxicity and safety. In this consensus document from a workshop on in-vitro cell systems for nanotoxicity testing an overview is given of the main issues concerningmore » inhalation exposure to nanoparticles, lung physiology, nanoparticle-related biological mechanisms, in-vitro cell exposure systems for nanoparticles and social aspects of nanotechnology. The workshop participants recognized the large potential of in-vitro cell exposure systems for reliable, high-throughput screening of nanotoxicity. For the investigation of pulmonary nanotoxicity, a strong preference was expressed for air-liquid interface (ALI) cell exposure systems (rather than submerged cell exposure systems) as they closely resemble in-vivo conditions in the lungs and they allow for unaltered and dosimetrically accurate delivery of aerosolized nanoparticles to the cells. The members of the workshop believe that further advances in in-vitro cell exposure studies would be greatly facilitated by a more active role of the aerosol scientists. The technical know-how for developing and running ALI in-vitro exposure systems is available in the aerosol community and at the same time biologists/toxicologists are required for proper assessment of the biological impact of nanoparticles.« less

Women in science & engineering and minority engineering scholarships : year 2 report for 2007-2008 activities.

DOT National Transportation Integrated Search

2008-08-01

Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...

Women in science & engineering and minority engineering scholarships : year 3, report for 2008-2009 activities.

DOT National Transportation Integrated Search

2009-05-01

Support made scholarships available to minority and women students interested in engineering and science and significantly increased : the number of minority and female students that Missouri S&T can recruit to its science and engineering programs. R...

Bacterial cell-free expression technology to in vitro systems engineering and optimization.

PubMed

Caschera, Filippo

2017-06-01

Cell-free expression system is a technology for the synthesis of proteins in vitro . The system is a platform for several bioengineering projects, e.g. cell-free metabolic engineering, evolutionary design of experiments, and synthetic minimal cell construction. Bacterial cell-free protein synthesis system (CFPS) is a robust tool for synthetic biology. The bacteria lysate, the DNA, and the energy module, which are the three optimized sub-systems for in vitro protein synthesis, compose the integrated system. Currently, an optimized E. coli cell-free expression system can produce up to ∼2.3 mg/mL of a fluorescent reporter protein. Herein, I will describe the features of ATP-regeneration systems for in vitro protein synthesis, and I will present a machine-learning experiment for optimizing the protein yield of E. coli cell-free protein synthesis systems. Moreover, I will introduce experiments on the synthesis of a minimal cell using liposomes as dynamic containers, and E. coli cell-free expression system as biochemical platform for metabolism and gene expression. CFPS can be further integrated with other technologies for novel applications in environmental, medical and material science.

Science/Engineering: Open Doors

NASA Technical Reports Server (NTRS)

White, Susan; Arnold, James O. (Technical Monitor)

1999-01-01

Trends in American society are changing the role of women in science and engineering, but all the elements in our society change at different rates. Women, like men, must choose during their teenage years to continue their training in math or science, or they close the door that can lead them to futures in the interesting and satisfying fields of science and engineering. The key is to keep girls involved in the hard sciences through the adolescent crisis. Many mentoring and outreach programs exist to help young women cross this threshold. These programs include hands-on science experiences, mentoring or putting young women in contact with women scientists and engineers, and internships, Viewpoints and histories of contemporary women engineers are discussed.

Make Room for Engineering

ERIC Educational Resources Information Center

Boesdorfer, Sarah; Greenhalgh, Scott

2014-01-01

The "Next Generation Science Standards" (NGSS Lead States 2013) urge science teachers to include engineering practices and ideas in their already full science curriculum, but many teachers do not know where to start. Only 7% of high school science teachers report feeling "very well prepared" to teach engineering. The…

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

A young girl watches as her paper airplane is flown in a small wind tunnel during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

USA Science and Engineering Festival

NASA Image and Video Library

2010-10-22

Priniciples of air flow are explained to visitors to the wind tunnel exhibit at the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

75 FR 22576 - Minority Science and Engineering Improvement Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... DEPARTMENT OF EDUCATION [CFDA No. 84.120A] Minority Science and Engineering Improvement Program... the fiscal year (FY) 2009 grant slate for the Minority Science and Engineering Improvement Program... Engineering Improvement Program (MSEIP), authorized by Title III, Part E of the Higher Education Act of 1965...

Is It Engineering or Not?

ERIC Educational Resources Information Center

Whitworth, Brooke A.; Wheeler, Lindsay B.

2017-01-01

With the widespread adoption of the "Next Generation Science Standards" (NGSS Lead States 2013), science teachers now aspire to integrate engineering into science instruction, as the standards suggest, yet many do not know how. The first steps are to define engineering and identify tasks that incorporate engineering, which can be…

Stationary Engineering. Science Manual--2.

ERIC Educational Resources Information Center

Frost, Harold J.; Steingress, Frederick M.

This second-year student manual contains 140 brief related science lessons applying science and math to trade activities in the field of stationary engineering. The lessons are organized into 16 units: (1) Introduction to Stationary Engineering, (2) Engineering Fundamentals, (3) Steam Boilers, (4) Boiler Fittings, (5) Boilerroom System, (6)…

Science Teachers' Misconceptions in Science and Engineering Distinctions: Reflections on Modern Research Examples

ERIC Educational Resources Information Center

Antink-Meyer, Allison; Meyer, Daniel Z.

2016-01-01

The aim of this exploratory study was to learn about the misconceptions that may arise for elementary and high school science teachers in their reflections on science and engineering practice. Using readings and videos of real science and engineering work, teachers' reflections were used to uncover the underpinnings of their understandings. This…

FWP executive summaries: basic energy sciences materials sciences and engineering program (SNL/NM).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samara, George A.; Simmons, Jerry A.

2006-07-01

This report presents an Executive Summary of the various elements of the Materials Sciences and Engineering Program which is funded by the Division of Materials Sciences and Engineering, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico. A general programmatic overview is also presented.

Graphene and its nanostructure derivatives for use in bone tissue engineering: Recent advances.

PubMed

Shadjou, Nasrin; Hasanzadeh, Mohammad

2016-05-01

Tissue engineering and regenerative medicine represent areas of increasing interest because of the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Graphene and its derivatives have attracted much interest for applications in bone tissue engineering. For this purpose, this review focuses on more recent advances in tissue engineering based on graphene-biomaterials from 2013 to May 2015. The purpose of this article was to give a general description of studies of nanostructured graphene derivatives for bone tissue engineering. In this review, we highlight how graphene family nanomaterials are being exploited for bone tissue engineering. Firstly, the main requirements for bone tissue engineering were discussed. Then, the mechanism by which graphene based materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. In addition, graphene-based bioactive glass, as a potential drug/growth factor carrier, was reviewed which includes the composition-structure-drug delivery relationship and the functional effect on the tissue-stimulation properties. Also, the effect of structural and textural properties of graphene based materials on development of new biomaterials for production of bone implants and bone cements were discussed. Finally, the present review intends to provide the reader an overview of the current state of the graphene based biomaterials in bone tissue engineering, its limitations and hopes as well as the future research trends for this exciting field of science. © 2016 Wiley Periodicals, Inc.

Genetic tool development and systemic regulation in biosynthetic technology.

PubMed

Dai, Zhongxue; Zhang, Shangjie; Yang, Qiao; Zhang, Wenming; Qian, Xiujuan; Dong, Weiliang; Jiang, Min; Xin, Fengxue

2018-01-01

With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical genetic engineering and metabolic engineering. It gives a wider perspective and a deeper level to perceive the nature of life via cell mechanism, regulatory networks, or biological evolution. Currently, synthetic biology has made great breakthrough in energy, chemical industry, and medicine industries, particularly in the programmable genetic control at multiple levels of regulation to perform designed goals. In this review, the most advanced and comprehensive developments achieved in biosynthetic technology were represented, including genetic engineering as well as synthetic genomics. In addition, the superiority together with the limitations of the current genome-editing tools were summarized.

Science and Engineering Indicators 2010

ERIC Educational Resources Information Center

National Science Foundation, 2010

2010-01-01

The Science Indicators series was designed to provide a broad base of quantitative information about U.S. science, engineering, and technology for use by policymakers, researchers, and the general public. "Science and Engineering Indicators 2010" contains analyses of key aspects of the scope, quality, and vitality of the Nation's science…

The College Science Learning Cycle: An Instructional Model for Reformed Teaching.

PubMed

Withers, Michelle

2016-01-01

Finding the time for developing or locating new class materials is one of the biggest barriers for instructors reforming their teaching approaches. Even instructors who have taken part in training workshops may feel overwhelmed by the task of transforming passive lecture content to engaging learning activities. Learning cycles have been instrumental in helping K-12 science teachers design effective instruction for decades. This paper introduces the College Science Learning Cycle adapted from the popular Biological Sciences Curriculum Study 5E to help science, technology, engineering, and mathematics faculty develop course materials to support active, student-centered teaching approaches in their classrooms. The learning cycle is embedded in backward design, a learning outcomes-oriented instructional design approach, and is accompanied by resources and examples to help faculty transform their teaching in a time-efficient manner. © 2016 M. Withers. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

PREFACE: International Conference on Applied Sciences (ICAS2014)

NASA Astrophysics Data System (ADS)

Lemle, Ludovic Dan; Jiang, Yiwen

2015-06-01

The International Conference on Applied Sciences (ICAS2014) took place in Hunedoara, Romania from 2-4 October 2014 at the Engineering Faculty of Hunedoara. The conference takes place alternately in Romania and in P.R. China and is organized by "Politehnica" University of Timisoara, Romania, and Military Economics Academy of Wuhan, P.R. China, with the aim to serve as a platform for exchange of information between various areas of applied sciences and to promote the communication between scientists of different nations, countries and continents. The topics of the conference covered a comprehensive spectrum of issues: 1. Economical Sciences 2. Engineering Sciences 3. Fundamental Sciences 4. Medical Sciences The conference gathered qualified researchers whose expertise can be used to develop new engineering knowledge that has the potential for application in economics, defense, medicine, etc. There were nearly 100 registered participants from six countries, and four invited and 56 oral talks were delivered during the two days of the conference. Based on the work presented at the conference, selected papers are included in this volume of IOP Conference Series: Materials Science and Engineering. These papers present new research in the various fields of Materials Engineering, Mechanical Engineering, Computer Engineering, and Mathematical Engineering. It is our great pleasure to present this volume of IOP Conference Series: Materials Science and Engineering to the scientific community to promote further research in these areas. We sincerely hope that the papers published in this volume will contribute to the advancement of knowledge in their respective fields.

Multiple case studies of STEM teachers' orientations to science teaching through engineering design

NASA Astrophysics Data System (ADS)

Rupp, Madeline

The following master's thesis is composed of two manuscripts describing STEM teachers' orientations to science teaching through engineering within the context of the Science Learning through Engineering Design (SLED) partnership. The framework guiding both studies was science teaching orientations, a component of pedagogical content knowledge. Data were collected via semi-structured interviews, multi-day classroom observations, pre- and post-observation interviews, implementation plans, and written reflections. Data sources were analyzed to generate two orientations to science teaching through engineering design for each participant. The first manuscript illustrates a single case study conducted with a sixth grade STEM teacher. Results of this study revealed a detailed picture of the teacher's goals, practices, assessments, and general views when teaching science through engineering design. Common themes across the teacher's instruction were used to characterize her orientations to science teaching through engineering design. Overall, the teacher's orientations showed a shift in her practice from didactic to student-centered methods of teaching as a result of integrating engineering design-based curriculum. The second manuscript describes a comparative case study of two sixth grade SLED participants. Results of this study revealed more complex and diverse relationships between the teachers' orientations to teaching science through engineering design and their instruction. Participants' orientations served as filters for instruction, guided by their divergent purposes for science teaching. Furthermore, their orientations and resulting implementation were developed from knowledge gained in teacher education, implying that teacher educators and researchers can use this framework to learn more about how teachers' knowledge is used to integrate engineering and science practices in the K-12 classroom.

STEM Integration in Middle School Life Science: Student Learning and Attitudes

NASA Astrophysics Data System (ADS)

Guzey, S. Selcen; Moore, Tamara J.; Harwell, Michael; Moreno, Mario

2016-08-01

In many countries around the world, there has been an increasing emphasis on improving science education. Recent reform efforts in the USA call for teachers to integrate scientific and engineering practices into science teaching; for example, science teachers are asked to provide learning experiences for students that apply crosscutting concepts (e.g., patterns, scale) and increase understanding of disciplinary core ideas (e.g., physical science, earth science). Engineering practices and engineering design are essential elements of this new vision of science teaching and learning. This paper presents a research study that evaluates the effects of an engineering design-based science curriculum on student learning and attitudes. Three middle school life science teachers and 275 seventh grade students participated in the study. Content assessments and attitude surveys were administered before and after the implementation of the curriculum unit. Statewide mathematics test proficiency scores were included in the data analysis as well. Results provide evidence of the positive effects of implementing the engineering design-based science unit on student attitudes and learning.

3D bioprinting of tissues and organs.

PubMed

Murphy, Sean V; Atala, Anthony

2014-08-01

Additive manufacturing, otherwise known as three-dimensional (3D) printing, is driving major innovations in many areas, such as engineering, manufacturing, art, education and medicine. Recent advances have enabled 3D printing of biocompatible materials, cells and supporting components into complex 3D functional living tissues. 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation. Compared with non-biological printing, 3D bioprinting involves additional complexities, such as the choice of materials, cell types, growth and differentiation factors, and technical challenges related to the sensitivities of living cells and the construction of tissues. Addressing these complexities requires the integration of technologies from the fields of engineering, biomaterials science, cell biology, physics and medicine. 3D bioprinting has already been used for the generation and transplantation of several tissues, including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures. Other applications include developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves.

PubMed

Ding, Xiaoyun; Lin, Sz-Chin Steven; Kiraly, Brian; Yue, Hongjun; Li, Sixing; Chiang, I-Kao; Shi, Jinjie; Benkovic, Stephen J; Huang, Tony Jun

2012-07-10

Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based "acoustic tweezers" that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans) in a single-layer microfluidic chip. Our acoustic tweezers utilize the wide resonance band of chirped interdigital transducers to achieve real-time control of a standing surface acoustic wave field, which enables flexible manipulation of most known microparticles. The power density required by our acoustic device is significantly lower than its optical counterparts (10,000,000 times less than optical tweezers and 100 times less than optoelectronic tweezers), which renders the technique more biocompatible and amenable to miniaturization. Cell-viability tests were conducted to verify the tweezers' compatibility with biological objects. With its advantages in biocompatibility, miniaturization, and versatility, the acoustic tweezers presented here will become a powerful tool for many disciplines of science and engineering.

Extracellular vesicles at the cross-line between basic science and clinical needs.

PubMed

Sasso, Luana; Hosamuddin, Huma; Emanueli, Costanza

2017-01-01

MiRNAs are small noncoding RNAs vital for protein regulation and gene expression. Since their discovery in the early nineties, many of their intracellular roles have been characterized. However, it is only recently that EVs loaded with miRNAs and other molecular types have started to be appreciated for their substantial involvement in cell-to-cell communication and signaling in physiological and pathological processes. EVs cell-to-cell signaling functions are complex and largely unknown, which still hampers the direct use of endogenous engineered EVs as therapeutics. However, ad hoc engineered synthetic EVs could represent new therapeutics. The potential of EV-inspired delivery carriers has now attracted the interest of the pharmaceutical industry and has challenged drug delivery researchers with new questions. This review will focus on EVs and EV-inspired drug delivery carriers, on their potential and on the challenges involved in the use of EV-inspired drug delivery systems. © 2016 John Wiley & Sons Ltd.

PREFACE: International Conference on Applied Sciences 2015 (ICAS2015)

NASA Astrophysics Data System (ADS)

Lemle, Ludovic Dan; Jiang, Yiwen

2016-02-01

The International Conference on Applied Sciences ICAS2015 took place in Wuhan, China on June 3-5, 2015 at the Military Economics Academy of Wuhan. The conference is regularly organized, alternatively in Romania and in P.R. China, by Politehnica University of Timişoara, Romania, and Military Economics Academy of Wuhan, P.R. China, with the joint aims to serve as a platform for exchange of information between various areas of applied sciences, and to promote the communication between the scientists of different nations, countries and continents. The topics of the conference cover a comprehensive spectrum of issues from: >Economical Sciences and Defense: Management Sciences, Business Management, Financial Management, Logistics, Human Resources, Crisis Management, Risk Management, Quality Control, Analysis and Prediction, Government Expenditure, Computational Methods in Economics, Military Sciences, National Security, and others... >Fundamental Sciences and Engineering: Interdisciplinary applications of physics, Numerical approximation and analysis, Computational Methods in Engineering, Metallic Materials, Composite Materials, Metal Alloys, Metallurgy, Heat Transfer, Mechanical Engineering, Mechatronics, Reliability, Electrical Engineering, Circuits and Systems, Signal Processing, Software Engineering, Data Bases, Modeling and Simulation, and others... The conference gathered qualified researchers whose expertise can be used to develop new engineering knowledge that has applicability potential in Engineering, Economics, Defense, etc. The number of participants was 120 from 11 countries (China, Romania, Taiwan, Korea, Denmark, France, Italy, Spain, USA, Jamaica, and Bosnia and Herzegovina). During the three days of the conference four invited and 67 oral talks were delivered. Based on the work presented at the conference, 38 selected papers have been included in this volume of IOP Conference Series: Materials Science and Engineering. These papers present new research in the various fields of Materials Engineering, Mechanical Engineering, Computers Engineering, and Electrical Engineering. It's our great pleasure to present this volume of IOP Conference Series: Materials Science and Engineering to the scientific community to promote further research in these areas. We sincerely hope that the papers published in this volume will contribute to the advancement of knowledge in the respective fields.

Benefiting Female Students in Science, Math, and Engineering: The Nuts and Bolts of Establishing a WISE (Women in Science and Engineering) Learning Community

ERIC Educational Resources Information Center

Pace, Diana; Witucki, Laurie; Blumreich, Kathleen

2008-01-01

This paper describes the rationale and the step by step process for setting up a WISE (Women in Science and Engineering) learning community at one institution. Background information on challenges for women in science and engineering and the benefits of a learning community for female students in these major areas are described. Authors discuss…

Proceedings of the 22nd Project Integration Meeting

NASA Technical Reports Server (NTRS)

1983-01-01

This report describes progress made by the Flat-Plate Solar Array Project during the period January to September 1983. It includes reports on silicon sheet growth and characterization, module technology, silicon material, cell processing and high-efficiency cells, environmental isolation, engineering sciences, module performance and failure analysis and project analysis and integration. It includes a report on, and copies of visual presentations made at the 22nd Project Integration Meeting held at Pasadena, California, on September 28 and 29, 1983.

75 FR 14128 - Center for Nanoscale Science and Technology Postdoctoral Researcher and Visiting Fellow...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... Measurement Science and Engineering Program; Availability of Funds AGENCY: National Institute of Standards and... Measurement Science and Engineering Program. This program is intended to promote research, training, and... Visiting Fellow Measurement Science and Engineering Program are as follows: 1. To advance, through...

Science & Engineering Indicators 2016. National Science Board

ERIC Educational Resources Information Center

National Science Foundation, 2016

2016-01-01

"Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI includes an overview and seven chapters that follow a generally consistent pattern. The chapter titles are as follows: (1) Elementary and…

78 FR 64255 - Committee on Equal Opportunities in Science and Engineering; Cancellation of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... NATIONAL SCIENCE FOUNDATION Committee on Equal Opportunities in Science and Engineering; Cancellation of Meeting SUMMARY: As a result of the impact of the recent government shutdown, the National... in Science and Engineering meeting. The public notice for this committee was published in the Federal...

78 FR 64255 - Advisory Committee for Computer and Information Science and Engineering; Cancellation of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering; Cancellation of Meeting SUMMARY: As a result of the impact of the recent government shutdown, the... Committee for Computer and Information Science and Engineering meeting. The public notice for this committee...

34 CFR 637.2 - Who is eligible to receive a grant?

Code of Federal Regulations, 2011 CFR

2011-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.2 Who... defined in § 637.4; (3) Have a curriculum that includes science or engineering subjects; and (4) Enter... baccalaureate degrees in science and engineering. (c) Nonprofit science-oriented organizations, professional...

34 CFR 637.2 - Who is eligible to receive a grant?

Code of Federal Regulations, 2012 CFR

2012-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.2 Who... defined in § 637.4; (3) Have a curriculum that includes science or engineering subjects; and (4) Enter... baccalaureate degrees in science and engineering. (c) Nonprofit science-oriented organizations, professional...

34 CFR 637.2 - Who is eligible to receive a grant?

Code of Federal Regulations, 2014 CFR

2014-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.2 Who... defined in § 637.4; (3) Have a curriculum that includes science or engineering subjects; and (4) Enter... baccalaureate degrees in science and engineering. (c) Nonprofit science-oriented organizations, professional...

34 CFR 637.2 - Who is eligible to receive a grant?

Code of Federal Regulations, 2010 CFR

2010-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.2 Who... defined in § 637.4; (3) Have a curriculum that includes science or engineering subjects; and (4) Enter... baccalaureate degrees in science and engineering. (c) Nonprofit science-oriented organizations, professional...

34 CFR 637.2 - Who is eligible to receive a grant?

Code of Federal Regulations, 2013 CFR

2013-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.2 Who... defined in § 637.4; (3) Have a curriculum that includes science or engineering subjects; and (4) Enter... baccalaureate degrees in science and engineering. (c) Nonprofit science-oriented organizations, professional...

Engineering Protein Hydrogels Using SpyCatcher-SpyTag Chemistry.

PubMed

Gao, Xiaoye; Fang, Jie; Xue, Bin; Fu, Linglan; Li, Hongbin

2016-09-12

Constructing hydrogels from engineered proteins has attracted significant attention within the material sciences, owing to their myriad potential applications in biomedical engineering. Developing efficient methods to cross-link tailored protein building blocks into hydrogels with desirable mechanical, physical, and functional properties is of paramount importance. By making use of the recently developed SpyCatcher-SpyTag chemistry, we successfully engineered protein hydrogels on the basis of engineered tandem modular elastomeric proteins. Our resultant protein hydrogels are soft but stable, and show excellent biocompatibility. As the first step, we tested the use of these hydrogels as a drug carrier, as well as in encapsulating human lung fibroblast cells. Our results demonstrate the robustness of the SpyCatcher-SpyTag chemistry, even when the SpyTag (or SpyCatcher) is flanked by folded globular domains. These results demonstrate that SpyCatcher-SpyTag chemistry can be used to engineer protein hydrogels from tandem modular elastomeric proteins that can find applications in tissue engineering, in fundamental mechano-biological studies, and as a controlled drug release vehicle.

Regenerative medicine as applied to solid organ transplantation: current status and future challenges

PubMed Central

Orlando, Giuseppe; Baptista, Pedro; Birchall, Martin; De Coppi, Paolo; Farney, Alan; Guimaraes-Souza, Nadia K.; Opara, Emmanuel; Rogers, Jeffrey; Seliktar, Dror; Shapira-Schweitzer, Keren; Stratta, Robert J.; Atala, Anthony; Wood, Kathryn J.; Soker, Shay

2013-01-01

Summary In the last two decades, regenerative medicine has shown the potential for “bench-to-bedside” translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were implanted without the reconstruction of the vascular supply, and the nutrients and oxygen were supplied by diffusion from adjacent tissues. Engineering of modular organs (namely, organs organized in functioning units referred to as modules and requiring the reconstruction of the vascular supply) is more complex and challenging. Models of functioning hearts and livers have been engineered using “natural tissue” scaffolds and efforts are underway to produce kidneys, pancreata and small intestine. Creation of custom-made bioengineered organs, where the cellular component is exquisitely autologous and have an internal vascular network, will theoretically overcome the two major hurdles in transplantation, namely the shortage of organs and the toxicity deriving from lifelong immuno-suppression. This review describes recent advances in the engineering of several key tissues and organs. PMID:21062367

Optical Science and Engineering. New Directions and Opportunities in Research and Education. NSF Workshop (Arlington, VA, May 23-24, 1994).

ERIC Educational Resources Information Center

National Science Foundation, Arlington, VA.

The National Science Foundation (NSF) workshop on Optical Science and Engineering was organized to examine approaches NSF could use to identify opportunities in optical science, engineering, and education that meet both the mission of NSF and its broader national goals. The workshop participants identified opportunities where optical science and…

Europe Report, Science and Technology.

DTIC Science & Technology

1986-06-06

the question, of course , whether the combined treatment will cause chromosome damage. In the case of chromosomes from in vitro cultivated human ...latest acquisition, this division collaborates to major engine programs, in particular with Snecma ( Atar , CFM 56) and Turbomeca (ARTM 405). 9294 CSO...microbiology, enzymology, molecular and cell biology , organic chemistry, etc. Several large public research organizations are involved: CNRS [National

"Shrink Wrapping" Lectures: Teaching Cell and Molecular Biology within the Context of Human Pathologies

ERIC Educational Resources Information Center

Guilford, William H.

2005-01-01

Students are most motivated and learn best when they are immersed in an environment that causes them to realize why they should learn. Perhaps nowhere is this truer than when teaching the biological sciences to engineers. Transitioning from a traditionally mathematics-based to a traditionally knowledge-based pedagogical style can challenge student…

West Europe Report, Science and Technology, No. 136.

DTIC Science & Technology

1983-02-01

their barriers and work with the large enterprises (Pechiney, Sanofi , Rhone- Poulenc) or the small and medium-size industrial enterprises on specific...traditional products of the agro-nutritional industries, —production of amino acids, antibiotics, vitamins, vaccines , hormones, en- zymes and...systems engineering; 4. Production of bioreagents for analysis, vaccines , monoclonal antibodies, and new cell-derived products for therapeutic

From the NSF: The National Science Foundation's Investments in Broadening Participation in Science, Technology, Engineering, and Mathematics Education through Research and Capacity Building.

PubMed

James, Sylvia M; Singer, Susan R

The National Science Foundation (NSF) has a long history of investment in broadening participation (BP) in science, technology, engineering, and mathematics (STEM) education. A review of past NSF BP efforts provides insights into how the portfolio of programs and activities has evolved and the broad array of innovative strategies that has been used to increase the participation of groups underrepresented in STEM, including women, minorities, and persons with disabilities. While many are familiar with these long-standing programmatic efforts, BP is also a key component of NSF's strategic plans, has been highlighted in National Science Board reports, and is the focus of ongoing outreach efforts. The majority of familiar BP programs, such as the Louis Stokes Alliances for Minority Participation (now 25 years old), are housed in the Directorate for Education and Human Resources. However, fellowship programs such as the Graduate Research Fellowships and Postdoctoral Research Fellowships under the Directorate for Biological Sciences (and parallel directorates in other STEM disciplines) are frequently used to address underrepresentation in STEM disciplines. The FY2016 and FY2017 budget requests incorporate funding for NSF INCLUDES, a new cross-agency BP initiative that will build on prior successes while addressing national BP challenges. NSF INCLUDES invites the use of innovative approaches for taking evidence-based best practices to scale, ushering in a new era in NSF BP advancement. © 2016 S. M. James and S. R. Singer. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Does it matter what we call it?

USDA-ARS?s Scientific Manuscript database

Agronomy, soil science, plant science, crop science, agricultural science, computer science, environmental science, environmental engineering, agricultural and irrigation engineering, hydrology, meteorology – all are names that describe fields of study relevant to agriculture and the environment in ...

Reaching Students: What Research Says about Effective Instruction in Undergraduate Science and Engineering

ERIC Educational Resources Information Center

Kober, Nancy

2015-01-01

The undergraduate years are a turning point in producing scientifically literate citizens and future scientists and engineers. Evidence from research about how students learn science and engineering shows that teaching strategies that motivate and engage students will improve their learning. So how do students best learn science and engineering?…

Distance Learning and Skill Acquisition in Engineering Sciences: Present State and Prospects

ERIC Educational Resources Information Center

Potkonjak, Veljko; Jovanovic, Kosta; Holland, Owen; Uhomoibhi, James

2013-01-01

Purpose: The purpose of this paper is to present an improved concept of software-based laboratory exercises, namely a Virtual Laboratory for Engineering Sciences (VLES). Design/methodology/approach: The implementation of distance learning and e-learning in engineering sciences (such as Mechanical and Electrical Engineering) is still far behind…

32 CFR 22.105 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... knowledge and understanding in science and engineering, rather than the practical application of that... part, basic research includes: (1) Research-related, science and engineering education, including... to enhance the infrastructure for science and engineering research. Claim. A written demand or...

32 CFR 22.105 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... knowledge and understanding in science and engineering, rather than the practical application of that... part, basic research includes: (1) Research-related, science and engineering education, including... to enhance the infrastructure for science and engineering research. Claim. A written demand or...

32 CFR 22.105 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... knowledge and understanding in science and engineering, rather than the practical application of that... part, basic research includes: (1) Research-related, science and engineering education, including... to enhance the infrastructure for science and engineering research. Claim. A written demand or...

32 CFR 22.105 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... knowledge and understanding in science and engineering, rather than the practical application of that... part, basic research includes: (1) Research-related, science and engineering education, including... to enhance the infrastructure for science and engineering research. Claim. A written demand or...

The role of ethics in science and engineering.

PubMed

Johnson, Deborah G

2010-12-01

It is generally thought that science and engineering should never cross certain ethical lines. The idea connects ethics to science and engineering, but it frames the relationship in a misleading way. Moral notions and practices inevitably influence and are influenced by science and engineering. The important question is how such interactions should take place. Anticipatory ethics is a new approach that integrates ethics into technological development. Copyright © 2010 Elsevier Ltd. All rights reserved.

Research on Life Science and Life Support Engineering Problems of Manned Deep Space Exploration Mission

NASA Astrophysics Data System (ADS)

Qi, Bin; Guo, Linli; Zhang, Zhixian

2016-07-01

Space life science and life support engineering are prominent problems in manned deep space exploration mission. Some typical problems are discussed in this paper, including long-term life support problem, physiological effect and defense of varying extraterrestrial environment. The causes of these problems are developed for these problems. To solve these problems, research on space life science and space medical-engineering should be conducted. In the aspect of space life science, the study of space gravity biology should focus on character of physiological effect in long term zero gravity, co-regulation of physiological systems, impact on stem cells in space, etc. The study of space radiation biology should focus on target effect and non-target effect of radiation, carcinogenicity of radiation, spread of radiation damage in life system, etc. The study of basic biology of space life support system should focus on theoretical basis and simulating mode of constructing the life support system, filtration and combination of species, regulation and optimization method of life support system, etc. In the aspect of space medical-engineering, the study of bio-regenerative life support technology should focus on plants cultivation technology, animal-protein production technology, waste treatment technology, etc. The study of varying gravity defense technology should focus on biological and medical measures to defend varying gravity effect, generation and evaluation of artificial gravity, etc. The study of extraterrestrial environment defense technology should focus on risk evaluation of radiation, monitoring and defending of radiation, compound prevention and removal technology of dust, etc. At last, a case of manned lunar base is analyzed, in which the effective schemes of life support system, defense of varying gravity, defense of extraterrestrial environment are advanced respectively. The points in this paper can be used as references for intensive study on key technologies.

Nanomaterials and nanofabrication for biomedical applications

NASA Astrophysics Data System (ADS)

Cheng, Chao-Min; Chia-Wen Wu, Kevin

2013-08-01

Traditional boundaries between materials science and engineering and life sciences are rapidly disintegrating as interdisciplinary research teams develop new materials-science-based tools for exploring fundamental issues in both medicine and biology. With recent technological advances in multiple research fields such as materials science, cell and molecular biology and micro-/nano-technology, much attention is shifting toward evaluating the functional advantages of nanomaterials and nanofabrication, at the cellular and molecular levels, for specific, biomedically relevant applications. The pursuit of this direction enhances the understanding of the mechanisms of, and therapeutic potentials for, some of the most lethal diseases, including cardiovascular diseases, organ fibrosis and cancers. This interdisciplinary approach has generated great interest among researchers working in a wide variety of communities including industry, universities and research laboratories. The purpose of this focus issue in Science and Technology of Advanced Materials is to bridge nanotechnology and biology with medicine, focusing more on the applications of nanomaterials and nanofabrication in biomedically relevant issues. This focus issue, we believe, will provide a more comprehensive understanding of (i) the preparation of nanomaterials and the underlying mechanisms of nanofabrication, and (ii) the linkage of nanomaterials and nanofabrication with biomedical applications. The multidisciplinary focus issue that we have attempted to organize is of interest to various research fields including biomaterials and tissue engineering, bioengineering, nanotechnology and nanomaterials, i.e. chemistry, physics and engineering. Nanomaterials and nanofabrication topics addressed in this focus issue include sensing and diagnosis (e.g. immunosensing and diagnostic devices for diseases), cellular and molecular biology (e.g. probing cellular behaviors and stem cell differentiation) and drug delivery carriers (e.g. polymers, gold nanoparticles, Prussian blue nanoparticles, mesoporous silica nanoparticles and carbon-based nanomaterials). Here, we would like to show our deep appreciation to all authors and reviewers. Without their great help and contributions, this focus issue, including the review and original papers, would not have been published on schedule. This focus issue may not cover all issues in this emerging scientific field; however, we believe that our efforts have great potential 'to hurl a boulder to draw a jade' and ignite innovation and challenging discussion in the relevant scientific communities.

Projections of Science and Engineering Doctorate Supply and Utilization 1982 and 1987.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

This report represents the National Science Foundation's fourth projection analysis of science and engineering doctorate supply and utilization through 1987. The 1979 study incorporates the effect of the domestic market for highly trained science and engineering (S/E) personnel upon the numbers of S/E doctorates awarded by American universities.…

Student Interest in Engineering Design-Based Science

ERIC Educational Resources Information Center

Selcen Guzey, S.; Moore, Tamara J.; Morse, Gillian

2016-01-01

Current reform efforts in science education around the world call on teachers to use integrated approaches to teach science. As a part of such reform efforts in the United States, engineering practices and engineering design have been identified in K-12 science education standards. However, there is relatively little is known about effective ways…

78 FR 61870 - Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-04

... NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended... Committee for Computer and Information Science and Engineering (1115). Date/Time: Oct 31, 2013: 12:30 p.m...

78 FR 79014 - Advisory Committee for Computer and Information Science and Engineering Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended... and Information Science and Engineering (1115) DATE/TIME: January 14, 2014, 3:00 p.m. to 5:00 p.m...

Mentor awards

NASA Astrophysics Data System (ADS)

Showstack, Randy

The Association of Women in Science (AWIS) and the American Indian Science and Engineering Society (AISES) were two of 19 institutions and individuals that received presidential awards for excellence in science, mathematics, and engineering mentoring, on September 11.Neal Lane, Director of the National Science Foundation, says the awards, which include $10,000 grants, recognize “individuals and institutions working to heighten the participation of underrepresented groups in science, mathematics, and engineering.”

78 FR 32474 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

...; Programs to strengthen scientific and engineering research potential; Science and engineering education... support applied research was added to the Organic Act. In 1980, The Science and Engineering Equal... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY...

77 FR 31401 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

...; Programs to strengthen scientific and engineering research potential; Science and engineering education... support applied research was added to the Organic Act. In 1980, The Science and Engineering Equal... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY...

CRISPR-cas System as a Genome Engineering Platform: Applications in Biomedicine and Biotechnology.

PubMed

Hashemi, Atieh

2018-01-01

Genome editing mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and its associated proteins (Cas) has recently been considered to be used as efficient, rapid and site-specific tool in the modification of endogenous genes in biomedically important cell types and whole organisms. It has become a predictable and precise method of choice for genome engineering by specifying a 20-nt targeting sequence within its guide RNA. Firstly, this review aims to describe the biology of CRISPR system. Next, the applications of CRISPR-Cas9 in various ways, such as efficient generation of a wide variety of biomedically important cellular models as well as those of animals, modifying epigenomes, conducting genome-wide screens, gene therapy, labelling specific genomic loci in living cells, metabolic engineering of yeast and bacteria and endogenous gene expression regulation by an altered version of this system were reviewed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Mechanical Engineering | Classification | College of Engineering & Applied

Science.gov Websites

ProfessorMechanical Engineering(414) 229-6949avdeev@uwm.eduEng & Math Sciences 975 profile photo Robert Balmer, Sc . D.Professor EmeritusMechanical Engineering(414) 229-3374balmer@uwm.eduEng & Math Sciences E260 profile -6614wjchang@uwm.eduEng & Math Sciences 1113 profile photo Junhong Chen Ph.D.UWM Distinguished

76 FR 20051 - Advisory Committee for Computer and Information; Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... Engineering; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as... Committee for Computer and Information Science and Engineering--(1115). Date and Time: May 6, 2011 8:30 a.m... Engineering, National Science Foundation, 4201 Wilson Blvd., Suite 1105, Arlington, VA 22230. Telephone: (703...

From Scarcity to Visibility: Gender Differences in the Careers of Doctoral Scientists and Engineers.

ERIC Educational Resources Information Center

Long, J. Scott, Ed.

This study documents the changes that have occurred in the representation of women in science and engineering and the characteristics of women scientists and engineers. Data from two National Science Foundation databases, the Survey of Earned Doctorates for New Ph.D.s and the Survey of Doctoral Recipients for the science & engineering doctoral…

34 CFR Appendix to Part 648 - Academic Areas

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Electronic, and Communications Engineering 14.11Engineering Mechanics 14.12Engineering Physics 14.13Engineering Science 14.14Environmental/Environmental Health Engineering 14.15Geological Engineering 14... Arts and Art Studies 50.09Music 51.Health Professions and Related Sciences 51.01Chiropractic (D.C., D.C...

Biomedical Engineering | Classification | College of Engineering & Applied

Science.gov Websites

Engineering, Biomedical Engineering(414) 229-6614wjchang@uwm.eduEng & Math Sciences 1113 profile photo Malkoc, Ph.D.Visiting Assistant ProfessorBiomedical Engineering414-229-6919malkoc@uwm.eduEng & Math Engineering / Electrical Engineering(414) 229-3327misra@uwm.eduEng & Math Sciences E-314 profile photo

Atlas Career Path Guidebook: Patterns and Common Practices in Systems Engineers’ Development

DTIC Science & Technology

2018-01-16

Overview of Atlas Proficiency Model .............................................................................. 68 5.1.2. Math /Science/General... Math /Science/General Engineering ................................ 72 Figure 42. Distribution for individuals with highest proficiency self...assessment in Math /Science/General Engineering ..................................................................................... 73 Figure 43

Sandia National Laboratories: Exceptional Service in the National Interest

Science.gov Websites

Electromagnetics Engineering Science Geoscience Materials Science Nanodevices & Microsystems Radiation Effects Electromagnetics Engineering Science Geoscience Materials Science Nanodevices & Microsystems Radiation Effects Geoscience Materials Science Nanodevices & Microsystems Radiation Effects & High Energy Density

Myths and Motives behind STEM (Science, Technology, Engineering, and Mathematics) Education and the STEM-Worker Shortage Narrartive

ERIC Educational Resources Information Center

Stevenson, Heidi J.

2014-01-01

The Business Roundtable (2013) website presents a common narrative in regard to STEM (Science, Technology, Engineering and Mathematics) education, "American students are falling behind in math and science. Fewer and fewer students are pursuing careers in science, technology, engineering and mathematics, and American students are performing at…

Characterizing Elementary Teachers' Enactment of High-Leverage Practices through Engineering Design-Based Science Instruction

ERIC Educational Resources Information Center

Capobianco, Brenda M.; DeLisi, Jacqueline; Radloff, Jeffrey

2018-01-01

In an effort to document teachers' enactments of new reform in science teaching, valid and scalable measures of science teaching using engineering design are needed. This study describes the development and testing of an approach for documenting and characterizing elementary science teachers' multiday enactments of engineering design-based science…

Identifying and Verifying Earthquake Engineering Concepts to Create a Knowledge Base in STEM Education: A Modified Delphi Study

ERIC Educational Resources Information Center

Cavlazoglu, Baki; Stuessy, Carol L.

2017-01-01

Stakeholders in STEM education have called for integrating engineering content knowledge into STEM-content classrooms. To answer the call, stakeholders in science education announced a new framework, Next Generation Science Standards, which focuses on the integration of science and engineering in K-12 science education. However, research indicates…

The Physics of Living in Space: A Physicist's Attempt to Provide Science and Engineering Education for Non-Science Students.

ERIC Educational Resources Information Center

Holbrow, C. H.

1983-01-01

A course was developed to teach physics concepts and to help students understand mathematics, the nature and role of engineers and engineering in society, and to distinguish between science/technology from pseudo-science. Includes course goals/content, mechanics, start-up, and long-term projects. (JN)

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

PubMed

Sather, Blythe D; Romano Ibarra, Guillermo S; Sommer, Karen; Curinga, Gabrielle; Hale, Malika; Khan, Iram F; Singh, Swati; Song, Yumei; Gwiazda, Kamila; Sahni, Jaya; Jarjour, Jordan; Astrakhan, Alexander; Wagner, Thor A; Scharenberg, Andrew M; Rawlings, David J

2015-09-30

Genetic mutations or engineered nucleases that disrupt the HIV co-receptor CCR5 block HIV infection of CD4(+) T cells. These findings have motivated the engineering of CCR5-specific nucleases for application as HIV therapies. The efficacy of this approach relies on efficient biallelic disruption of CCR5, and the ability to efficiently target sequences that confer HIV resistance to the CCR5 locus has the potential to further improve clinical outcomes. We used RNA-based nuclease expression paired with adeno-associated virus (AAV)-mediated delivery of a CCR5-targeting donor template to achieve highly efficient targeted recombination in primary human T cells. This method consistently achieved 8 to 60% rates of homology-directed recombination into the CCR5 locus in T cells, with over 80% of cells modified with an MND-GFP expression cassette exhibiting biallelic modification. MND-GFP-modified T cells maintained a diverse repertoire and engrafted in immune-deficient mice as efficiently as unmodified cells. Using this method, we integrated sequences coding chimeric antigen receptors (CARs) into the CCR5 locus, and the resulting targeted CAR T cells exhibited antitumor or anti-HIV activity. Alternatively, we introduced the C46 HIV fusion inhibitor, generating T cell populations with high rates of biallelic CCR5 disruption paired with potential protection from HIV with CXCR4 co-receptor tropism. Finally, this protocol was applied to adult human mobilized CD34(+) cells, resulting in 15 to 20% homologous gene targeting. Our results demonstrate that high-efficiency targeted integration is feasible in primary human hematopoietic cells and highlight the potential of gene editing to engineer T cell products with myriad functional properties. Copyright © 2015, American Association for the Advancement of Science.

Wood formation in Angiosperms.

PubMed

Déjardin, Annabelle; Laurans, Françoise; Arnaud, Dominique; Breton, Christian; Pilate, Gilles; Leplé, Jean-Charles

2010-04-01

Wood formation is a complex biological process, involving five major developmental steps, including (1) cell division from a secondary meristem called the vascular cambium, (2) cell expansion (cell elongation and radial enlargement), (3) secondary cell wall deposition, (4) programmed cell death, and (5) heartwood formation. Thanks to the development of genomic studies in woody species, as well as genetic engineering, recent progress has been made in the understanding of the molecular mechanisms underlying wood formation. In this review, we will focus on two different aspects, the lignification process and the control of microfibril angle in the cell wall of wood fibres, as they are both key features of wood material properties. Copyright (c) 2010 Académie des sciences. Published by Elsevier SAS. All rights reserved.

Do Biology Majors Really Differ from Non-STEM Majors?

PubMed

Cotner, Sehoya; Thompson, Seth; Wright, Robin

2017-01-01

Recent calls to action urge sweeping reform in science education, advocating for improved learning for all students-including those majoring in fields beyond the sciences. However, little work has been done to characterize the differences-if any exist-between students planning a career in science and those studying other disciplines. We describe an attempt to clarify, in broad terms, how non-STEM (science, technology, engineering, and mathematics) majors differ from life sciences majors, and how they are similar. Using survey responses and institutional data, we find that non-STEM majors are not unilaterally science averse; non-STEM majors are more likely than biology majors to hold misconceptions about the nature of science, yet they are not completely ignorant of how science works; non-STEM majors are less likely than biology majors to see science as personally relevant; and non-STEM majors populations are likely to be more diverse-with respect to incoming knowledge, perceptions, backgrounds, and skills-than a biology majors population. We encourage science educators to consider these characteristics when designing curricula for future scientists or simply for a well-informed citizenry. © 2017 S. Cotner et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

PubMed Central

Choi, Ji Sun; Mahadik, Bhushan P.; Harley, Brendan A. C.

2016-01-01

Hematopoietic stem cells (HSCs) play a crucial role in the generation of the body’s blood and immune cells. This process takes place primarily in the bone marrow in specialized ‘niche’ microenvironments, which provide signals responsible for maintaining a balance between HSC quiescence, self-renewal, and lineage specification required for life-long hematopoiesis. While our understanding of these signaling mechanisms continues to improve, our ability to engineer them in vitro for the expansion of clinically relevant HSC populations is still lacking. In this review, we focus on development of biomaterials-based culture platforms for in vitro study of interactions between HSCs and their local microenvironment. The tools and techniques used for both examining HSC-niche interactions as well as applying these findings towards controlled HSC expansion or directed differentiation in 2D and 3D platforms are discussed. These novel techniques hold the potential to push the existing boundaries of HSC cultures towards high-throughput, real-time, and single-cell level biomimetic approaches that enable a more nuanced understanding of HSC regulation and function. Their application in conjunction with innovative biomaterial platforms can pave the way for engineering artificial bone marrow niches for clinical applications as well as elucidating the pathology of blood-related cancers and disorders. PMID:26356030

Tendon Reconstruction with Tissue Engineering Approach--A Review.

PubMed

Verdiyeva, Gunay; Koshy, Kiron; Glibbery, Natalia; Mann, Haroon; Seifalian, Alexander M

2015-09-01

Tendon injuries are a common and rising occurrence, associated with significant impairment to quality of life and financial burden to the healthcare system. Clinically, they represent an unresolved problem, due to poor natural tendon healing and the inability of current treatment strategies to restore the tendon to its native state. Tissue engineering offers a promising alternative, with the incorporation of scaffolds, cells and growth factors to support the complete regeneration of the tendon. The materials used in tendon engineering to date have provided significant advances in structural integrity and biological compatibility and in many cases the results obtained are superior to those observed in natural healing. However, grafts fail to reproduce the qualities of the pre-injured tendon and each has weaknesses subject to its constituent parts. Furthermore, many materials and cell types are being investigated concurrently, with seemingly little association or comparison between research results. In this review the properties of the most-investigated and effective components have been appraised in light of the surrounding literature, with research from early in-vitro experiments to clinical trials being discussed. Extensive comparisons have been made between scaffolds, cell types and growth factors used, listing strengths and weaknesses to provide a stable platform for future research. Promising future endeavours are also described in the field of nanocomposite material science, stem cell sources and growth factors, which may bypass weaknesses found in individual elements. The future of tendon engineering looks bright, with growing understanding in material technology, cell and growth factor application and encouraging recent advances bringing us ever closer to regenerating the native tendon.

Single-Cell Microgels: Technology, Challenges, and Applications.

PubMed

Kamperman, Tom; Karperien, Marcel; Le Gac, Séverine; Leijten, Jeroen

2018-04-12

Single-cell-laden microgels effectively act as the engineered counterpart of the smallest living building block of life: a cell within its pericellular matrix. Recent breakthroughs have enabled the encapsulation of single cells in sub-100-μm microgels to provide physiologically relevant microniches with minimal mass transport limitations and favorable pharmacokinetic properties. Single-cell-laden microgels offer additional unprecedented advantages, including facile manipulation, culture, and analysis of individual cell within 3D microenvironments. Therefore, single-cell microgel technology is expected to be instrumental in many life science applications, including pharmacological screenings, regenerative medicine, and fundamental biological research. In this review, we discuss the latest trends, technical challenges, and breakthroughs, and present our vision of the future of single-cell microgel technology and its applications. Copyright © 2018 Elsevier Ltd. All rights reserved.

Tissue Engineered Skin and Wound Healing: Current Strategies and Future Directions.

PubMed

Bhardwaj, Nandana; Chouhan, Dimple; Mandal, Biman B

2017-01-01

The global volume of skin damage or injuries has major healthcare implications and, accounts for about half of the world's annual expenditure in the healthcare sector. In the last two decades, tissue-engineered skin constructs have shown great promise in the treatment of various skin-related disorders such as deep burns and wounds. The treatment methods for skin replacement and repair have evolved from utilization of autologous epidermal sheets to more complex bilayered cutaneous tissue engineered skin substitutes. However, inadequate vascularization, lack of flexibility in drug/growth factors loading and inability to reconstitute skin appendages such as hair follicles limits their utilization for restoration of normal skin anatomy on a routine basis. Recent advancements in cutting-edge technology from stem cell biology, nanotechnology, and various vascularization strategies have provided a tremendous springboard for researchers in developing and manipulating tissue engineered skin substitutes for improved skin regeneration and wound healing. This review summarizes the overview of skin tissue engineering and wound healing. Herein, developments and challenges of various available biomaterials, cell sources and in vitro skin models (full thickness and wound healing models) in tissue-engineered skin research are discussed. Furthermore, central to the discussion is the inclusion of various innovative strategies starting from stem cells, nanotechnology, vascularization strategies, microfluidics to three dimensional (3D) bioprinting based strategies for generation of complex skin mimics. The review then moves on to highlight the future prospects of advanced construction strategies of these bioengineered skin constructs and their contribution to wound healing and skin regeneration on current practice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

NASA's Information Power Grid: Large Scale Distributed Computing and Data Management

NASA Technical Reports Server (NTRS)

Johnston, William E.; Vaziri, Arsi; Hinke, Tom; Tanner, Leigh Ann; Feiereisen, William J.; Thigpen, William; Tang, Harry (Technical Monitor)

2001-01-01

Large-scale science and engineering are done through the interaction of people, heterogeneous computing resources, information systems, and instruments, all of which are geographically and organizationally dispersed. The overall motivation for Grids is to facilitate the routine interactions of these resources in order to support large-scale science and engineering. Multi-disciplinary simulations provide a good example of a class of applications that are very likely to require aggregation of widely distributed computing, data, and intellectual resources. Such simulations - e.g. whole system aircraft simulation and whole system living cell simulation - require integrating applications and data that are developed by different teams of researchers frequently in different locations. The research team's are the only ones that have the expertise to maintain and improve the simulation code and/or the body of experimental data that drives the simulations. This results in an inherently distributed computing and data management environment.

Interdisciplinary cantilever physics: Elasticity of carrot, celery, and plasticware

NASA Astrophysics Data System (ADS)

Pestka, Kenneth A.

2014-05-01

This article presents several simple cantilever-based experiments using common household items (celery, carrot, and a plastic spoon) that are appropriate for introductory undergraduate laboratories or independent student projects. By applying Hooke's law and Euler beam theory, students are able to determine Young's modulus, fracture stress, yield stress, strain energy, and sound speed of these apparently disparate materials. In addition, a cellular foam elastic model is introduced—applicable to biologic materials as well as an essential component in the development of advanced engineering composites—that provides a mechanism to determine Young's modulus of the cell wall material found in celery and carrot. These experiments are designed to promote exploration of the similarities and differences between common inorganic and organic materials, fill a void in the typical undergraduate curriculum, and provide a foundation for more advanced material science pursuits within biology, botany, and food science as well as physics and engineering.

Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications

NASA Astrophysics Data System (ADS)

McGann, Christopher Leland

Technological progress in the life sciences and engineering has combined with important insights in the fields of biology and material science to make possible the development of biological substitutes which aim to restore function to damaged tissue. Numerous biomimetic hydrogels have been developed with the purpose of harnessing the regenerative capacity of cells and tissue through the rational deployment of biological signals. Aided by recombinant DNA technology and protein engineering methods, a new class of hydrogel precursor, the biosynthetic protein polymer, has demonstrated great promise towards the development of highly functional tissue engineering materials. In particular, protein polymers based upon resilin, a natural protein elastomer, have demonstrated outstanding mechanical properties that would have great value in soft tissue applications. This dissertation introduces hybrid hydrogels composed of recombinant resilin-like polypeptides (RLPs) cross-linked with multi-arm PEG macromers. Two different chemical strategies were employed to form RLP-PEG hydrogels: one utilized a Michael-type addition reaction between the thiols of cysteine residues present within the RLP and vinyl sulfone moieties functionalized on a multi-arm PEG macromer; the second system cross-links a norbornene-functionalized RLP with a thiol-functionalized multi-arm PEG macromer via a photoinitiated thiol-ene step polymerization. Oscillatory rheology and tensile testing confirmed the formation of elastic, resilient hydrogels in the RLP-PEG system cross-linked via Michael-type addition. These hydrogels supported the encapsulation and culture of both human aortic adventitial fibroblasts and human mesenchymal stem cells. Additionally, these RLP-PEG hydrogels exhibited phase separation behavior during cross-linking that led to the formation of a heterogeneous microstructure. Degradation could be triggered through incubation with matrix metalloproteinase. Photocross-linking was conferred to RLPs through the successful conjugation of norbornene acid to the protein. Oscillatory rheology characterized the gelation and subsequent mechanical properties of the photoreactive RLP-PEG hydrogels while the cytocompatibility was confirmed via the successful encapsulation and culture of human mesenchymal stem cells. Both strategies demonstrate the utility of hybrid materials that combine biosynthetic proteins with synthetic polymers. As resilient and cytocompatible materials, RLP-PEG hybrid hydrogels offer an exciting strategy towards the development of biomimetic tissue engineering scaffolds for mechanically-demanding applications.

Women in science & engineering scholarships and summer camp outreach programs : year 6.

DOT National Transportation Integrated Search

2012-08-01

Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...

76 FR 12763 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... mandated reports such as Science and Engineering Indicators and Women, Minorities and Persons with Disabilities in Science and Engineering. Description of Respondents: Individuals. Number of Respondents: 51,000..., ``Science and Engineering Doctorate Awards'' and the Interagency Report, ``Doctorate Recipients from U.S...

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

Attendees of the USA Science and Engineering Festival explore all of the exhibits at the NASA Stage. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

Science and Technology Review June 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radousky, H

2006-04-20

This month's issue has the following articles: (1) Maintaining Excellence through Intellectual Vitality--Commentary by Cherry A. Murray; (2) Next-Generation Scientists and Engineers Tap Lab's Resources--University of California Ph.D. candidates work with Livermore scientists and engineers to conduct fundamental research as part of their theses; (3) Adaptive Optics Provide a Clearer View--The Center for Adaptive Optics is sharpening the view of celestial objects and retinal cells; (4) Wired on the Nanoscale--A Lawrence Fellow at Livermore is using genetically engineered viruses to create nanostructures such as tiny gold wires; and (5) Too Hot to Handle--Livermore scientists couple carbon-cycle and climate models tomore » predict the global effects of depleting Earth's fossil-fuel supply.« less

LIVIVO - the Vertical Search Engine for Life Sciences.

PubMed

Müller, Bernd; Poley, Christoph; Pössel, Jana; Hagelstein, Alexandra; Gübitz, Thomas

2017-01-01

The explosive growth of literature and data in the life sciences challenges researchers to keep track of current advancements in their disciplines. Novel approaches in the life science like the One Health paradigm require integrated methodologies in order to link and connect heterogeneous information from databases and literature resources. Current publications in the life sciences are increasingly characterized by the employment of trans-disciplinary methodologies comprising molecular and cell biology, genetics, genomic, epigenomic, transcriptional and proteomic high throughput technologies with data from humans, plants, and animals. The literature search engine LIVIVO empowers retrieval functionality by incorporating various literature resources from medicine, health, environment, agriculture and nutrition. LIVIVO is developed in-house by ZB MED - Information Centre for Life Sciences. It provides a user-friendly and usability-tested search interface with a corpus of 55 Million citations derived from 50 databases. Standardized application programming interfaces are available for data export and high throughput retrieval. The search functions allow for semantic retrieval with filtering options based on life science entities. The service oriented architecture of LIVIVO uses four different implementation layers to deliver search services. A Knowledge Environment is developed by ZB MED to deal with the heterogeneity of data as an integrative approach to model, store, and link semantic concepts within literature resources and databases. Future work will focus on the exploitation of life science ontologies and on the employment of NLP technologies in order to improve query expansion, filters in faceted search, and concept based relevancy rankings in LIVIVO.

Examining the Extent to Which Select Teacher Preparation Experiences Inform Technology and Engineering Educators' Teaching of Science Content and Practices

ERIC Educational Resources Information Center

Love, Tyler S.

2015-01-01

With the recent release of the "Next Generation Science Standards" (NGSS) (NGSS Lead States, 2014b) science educators were expected to teach engineering content and practices within their curricula. However, technology and engineering (T&E) educators have been expected to teach content and practices from engineering and other…

75 FR 19428 - Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Engineering; Notice of Meeting In accordance with the Federal Advisory Committee Act (Pub. L. 92- 463, as... Computer and Information Science and Engineering--(1115). Date and Time: May 7, 2010, 8:30 a.m.-5 p.m... Information Science and Engineering at 703/292-8900 prior to the meeting so that a visitor's badge may be...

Introducing Engineering Design to a Science Teaching Methods Course through Educational Robotics and Exploring Changes in Views of Preservice Elementary Teachers

ERIC Educational Resources Information Center

Kaya, Erdogan; Newley, Anna; Deniz, Hasan; Yesilyurt, Ezgi; Newley, Patrick

2017-01-01

Engineering has become an important subject in the Next Generation Science Standards (NGSS), which have raised engineering design to the same level as scientific inquiry when teaching science disciplines at all levels. Therefore, preservice elementary teachers (PSTs) need to know how to integrate the engineering design process (EDP) into their…

77 FR 66873 - Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... Engineering; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended... and Information Science and Engineering (1115). Date/Time: November 28, 2012: 12:00 p.m. to 5:30 p.m... Information Science and Engineering (CISE) community. To provide advice to the Assistant Director for CISE on...

Reviews of Data on Science Resources, No. 25. Doctoral Scientists and Engineers in Private Industry, 1973.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

Reported are manpower data needed by those engaged in science and engineering policy activities. The information is collected from scientists and engineers themselves. The basis of this report is the first survey, in a biennial series, of the Doctoral Roster of Scientists and Engineers, conducted for the National Science Foundation by the…

The Humanistic Side of Engineering: Considering Social Science and Humanities Dimensions of Engineering in Education and Research

ERIC Educational Resources Information Center

Hynes, Morgan; Swenson, Jessica

2013-01-01

Mathematics and science knowledge/skills are most commonly associated with engineering's pre-requisite knowledge. Our goals in this paper are to argue for a more systematic inclusion of social science and humanities knowledge in the introduction of engineering to K-12 students. As part of this argument, we present a construct for framing the…

Effectiveness of a Computer-Mediated Simulations Program in School Biology on Pupils' Learning Outcomes in Cell Theory

ERIC Educational Resources Information Center

Kiboss, Joel K.; Ndirangu, Mwangi; Wekesa, Eric W.

2004-01-01

Biology knowledge and understanding is important not only for the conversion of the loftiest dreams into reality for a better life of individuals but also for preparing secondary pupils for such fields as agriculture, medicine, biotechnology, and genetic engineering. But a recent study has revealed that many aspects of school science (biology…

Culturally Relevant Inquiry-Based Laboratory Module Implementations in Upper-Division Genetics and Cell Biology Teaching Laboratories

ERIC Educational Resources Information Center

Siritunga, Dimuth; Montero-Rojas, Maria; Carrero, Katherine; Toro, Gladys; Velez, Ana; Carrero-Martinez, Franklin A.

2011-01-01

Today, more minority students are entering undergraduate programs than ever before, but they earn only 6% of all science or engineering PhDs awarded in the United States. Many studies suggest that hands-on research activities enhance students' interest in pursuing a research career. In this paper, we present a model for the implementation of…

The 19th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1981-01-01

The Flat-Plate Solar Array Project is described. Project analysis and integration is discussed. Technology research in silicon material, large-area silicon sheet and environmental isolation; cell and module formation; engineering sciences, and module performance and failure analysis. It includes a report on, and copies of visual presentations made at, the 19th Project Integration Meeting held at Pasadena, California, on November 11, 1981.

Microgravity

NASA Image and Video Library

2000-12-15

Paul Ducheyne, a principal investigator in the microgravity materials science program and head of the University of Pernsylvania's Center for Bioactive Materials and Tissue Engineering, is leading the trio as they use simulated microgravity to determine the optimal characteristics of tiny glass particles for growing bone tissue. The result could make possible a much broader range of synthetic bone-grafting applications. Even in normal gravity, bioactive glass particles enhance bone growth in laboratory tests with flat tissue cultures. Ducheyne and his team believe that using the bioactive microcarriers in a rotating bioreactor in microgravity will produce improved, three-dimensional tissue cultures. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: NASA and University of Pennsylvania Center for Bioactive Materials and Tissue Engineering.

Heterologous Synthesis and Recovery of Advanced Biofuels from Bacterial Cell Factories.

PubMed

Malik, Sana; Afzal, Ifrah; Mehmood, Muhammad Aamer; Al Doghaither, Huda; Rahimuddin, Sawsan Abdulaziz; Gull, Munazza; Nahid, Nazia

2018-01-01

Microbial engineering to produce advanced biofuels is currently the most encouraging approach in renewable energy. Heterologous synthesis of biofuels and other useful industrial chemicals using bacterial cell factories has radically diverted the attentions from the native synthesis of these compounds. However, recovery of biofuels from the media and cellular toxicity are the main hindrances to successful commercialization of advanced biofuels. Therefore, membrane transporter engineering is gaining increasing attentions from all over the world. The main objective of this review is to explore the ways to increase the microbial production of biofuels by counteracting the cellular toxicity and facilitating their easier recovery from media. Microbial synthesis of industrially viable compounds such as biofuels has been increased due to genomic revolution. Moreover, advancements in protein engineering, gene regulation, pathway portability, metabolic engineering and synthetic biology led the focus towards the development of robust and cost-effective systems for biofuel production. The most convenient way to combat cellular toxicity and to secrete biofuels is the use of membrane transport system. The use of membrane transporters is currently a serious oversight as do not involve chemical changes and contribute greatly to efflux biofuels in extracellular milieu. However, overexpression of transport systems can also be detrimental to cell, so, in future, structure-based engineering of transporters can be employed to evaluate optimum expression range, to increase biofuel specificity and transport rate through structural studies of biofuel molecules. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Students' attitudes towards interdisciplinary education: a course on interdisciplinary aspects of science and engineering education

NASA Astrophysics Data System (ADS)

Gero, Aharon

2017-05-01

A course entitled 'Science and Engineering Education: Interdisciplinary Aspects' was designed to expose undergraduate students of science and engineering education to the attributes of interdisciplinary education which integrates science and engineering. The core of the course is an interdisciplinary lesson, which each student is supposed to teach his/her peers. Sixteen students at advanced stages of their studies attended the course. The research presented here used qualitative instruments to characterise students' attitudes towards interdisciplinary learning and teaching of science and engineering. According to the findings, despite the significant challenge which characterises interdisciplinary teaching, a notable improvement was evident throughout the course in the percentage of students who expressed willingness to teach interdisciplinary classes in future.

The Gender Differences: Hispanic Females and Males Majoring in Science or Engineering

NASA Astrophysics Data System (ADS)

Brown, Susan Wightman

Documented by national statistics, female Hispanic students are not eagerly rushing to major in science or engineering. Using Seidman's in-depth interviewing method, 22 Hispanic students, 12 female and 10 male, majoring in science or engineering were interviewed. Besides the themes that emerged with all 22 Hispanic students, there were definite differences between the female and male Hispanic students: role and ethnic identity confusion, greater college preparation, mentoring needed, and the increased participation in enriched additional education programs by the female Hispanic students. Listening to these stories from successful female Hispanic students majoring in science and engineering, educators can make changes in our school learning environments that will encourage and enable more female Hispanic students to choose science or engineering careers.

Using Arts Integration to Make Science Learning Memorable in the Upper Elementary Grades: A Quasi-Experimental Study

ERIC Educational Resources Information Center

Graham, Nicholas James; Brouillette, Liane

2016-01-01

The Next Generation Science Standards (NGSS) have brought a stronger emphasis on engineering into K-12 STEM (science, technology, engineering and mathematics) instruction. Introducing the design process used in engineering into science classrooms simulated a dialogue among some educators about adding the arts to the mix. This led to proposals for…

Activities of Science and Engineering Faculty in Universities and 4-Year Colleges: 1978/79. Final Report.

ERIC Educational Resources Information Center

Lacy, Larry W.; And Others

National estimates of activities of science and engineering faculty in universities and four-year colleges for 1978-1979 are examined, based on a National Science Foundation survey of faculty members in 20 science and engineering (S/E) fields. Individual respondents provided information for only one 7-day period; however, the survey sample was…

Building a Community of Scholars: One University's Story of Students Engaged in Learning Science, Mathematics, and Engineering through a NSF S-STEM Grant

ERIC Educational Resources Information Center

Kalevitch, Maria; Maurer, Cheryl; Badger, Paul; Holdan, Greg; Iannelli, Joe; Sirinterlikci, Arif; Semich, George; Bernauer, James

2012-01-01

The School of Engineering, Mathematics, and Science (SEMS) at Robert Morris University (RMU) was awarded a five-year grant from the National Science Foundation (NSF) to fund scholarships to 21 academically talented but financially challenged students majoring in the disciplines of science, technology, engineering, and mathematics (STEM). Each…

In Brief: Suresh slated to head U.S. National Science Foundation

NASA Astrophysics Data System (ADS)

Showstack, Randy

2010-06-01

U.S. president Barack Obama announced on 3 June his intent to nominate Subra Suresh as the next director of the U.S. National Science Foundation (NSF). Arden Bement, who served as NSF director since 2004, resigned earlier this year to lead Purdue University's Global Policy Research Institute, in West Lafayette, Indiana. Suresh is dean of the School of Engineering and the Vannevar Bush Professor of Engineering at Massachusetts Institute of Technology (MIT), Cambridge. Suresh joined MIT in 1993 as the R. P. Simmons Professor of Materials Science and Engineering. Since then, he has held joint faculty appointments in the departments of Mechanical Engineering and Biological Engineering, as well as the Division of Health Sciences and Technology. He previously was head of the university's Department of Materials Science and Engineering. Suresh has a B.S. from the Indian Institute of Technology, Madras, India; an M.S. from Iowa State University of Science and Technology, Ames; and a Sc.D. from MIT.

The Quantum Engineering Conundrum

NASA Astrophysics Data System (ADS)

Monroe, Christopher

2017-04-01

There is newfound rush and excitement in Quantum Information Science, as this field seems to be moving toward an industrial/engineering phase. However, this evolution will require that quantum science, long the domain of academics and other researchers, make the leap to sustained engineering efforts in order to fabricate practical devices. I will address the conundrum, that full-blooded engineering does not generally happen on campuses, while many in the professional engineering and computer science community do not believe in quantum physics!

High-throughput proteomics : optical approaches.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davidson, George S.

2008-09-01

Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become availablemore » that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.« less

Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

PubMed Central

Gong, Ting; Heng, Boon Chin; Lo, Edward Chin Man; Zhang, Chengfei

2016-01-01

Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. PMID:27069484

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

PubMed Central

Caddeo, Silvia; Boffito, Monica; Sartori, Susanna

2017-01-01

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the “3Rs” guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented. PMID:28798911

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models.

PubMed

Caddeo, Silvia; Boffito, Monica; Sartori, Susanna

2017-01-01

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the "3Rs" guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented.

Human Systems Integration Competency Development for Navy Systems Commands

DTIC Science & Technology

2012-09-01

cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences. KSA...cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences...requirements (as required). Fundamental cognizance of Applied Engineering / Psychology relative to knowledge engineering, training, team work, user

The Institute of Biological Engineering 2013 Annual Conference

DTIC Science & Technology

2014-10-30

of Bioengineering University of Washington Presentation: Peptide-Based materials for Drug Delivery Dr. Ya-Ping Sun (Supported by the Grant) Frank...Professor of Biomedical Engineering and Mechanical Engineering and Materials Science Duke University Presentation: Acoustic Microfluidics and New...Triangle Materials Research Science and Engineering Center, Department of Biomedical Engineering, Duke University, Department of Mechanical Engineering

Engineering design skills coverage in K-12 engineering program curriculum materials in the USA

NASA Astrophysics Data System (ADS)

Chabalengula, Vivien M.; Mumba, Frackson

2017-11-01

The current K-12 Science Education framework and Next Generation Science Standards (NGSS) in the United States emphasise the integration of engineering design in science instruction to promote scientific literacy and engineering design skills among students. As such, many engineering education programmes have developed curriculum materials that are being used in K-12 settings. However, little is known about the nature and extent to which engineering design skills outlined in NGSS are addressed in these K-12 engineering education programme curriculum materials. We analysed nine K-12 engineering education programmes for the nature and extent of engineering design skills coverage. Results show that developing possible solutions and actual designing of prototypes were the highly covered engineering design skills; specification of clear goals, criteria, and constraints received medium coverage; defining and identifying an engineering problem; optimising the design solution; and demonstrating how a prototype works, and making iterations to improve designs were lowly covered. These trends were similar across grade levels and across discipline-specific curriculum materials. These results have implications on engineering design-integrated science teaching and learning in K-12 settings.

Examining Teacher Talk in an Engineering Design-Based Science Curricular Unit

NASA Astrophysics Data System (ADS)

Aranda, Maurina L.; Lie, Richard; Selcen Guzey, S.; Makarsu, Murat; Johnston, Amanda; Moore, Tamara J.

2018-03-01

Recent science education reforms highlight the importance for teachers to implement effective instructional practices that promote student learning of science and engineering content and their practices. Effective classroom discussion has been shown to support the learning of science, but work is needed to examine teachers' enactment of engineering design-based science curricula by focusing on the content, complexity, structure, and orchestration of classroom discussions. In the present study, we explored teacher-student talk with respect to science in a middle school curriculum focused on genetics and genetic engineering. Our study was guided by the following major research question: What are the similarities and differences in teacher talk moves that occurred within an engineering design-based science unit enacted by two teachers? Through qualitative and quantitative approaches, we found that there were clear differences in two teachers' use of questioning strategies and presentation of new knowledge that affected the level of student involvement in classroom discourse and the richness and details of student contributions to the conversations. We also found that the verbal explanations of science content differed between two teachers. Collectively, the findings in this study demonstrate that although the teachers worked together to design an engineering designed-based science curriculum unit, their use of different discussion strategies and patterns, and interactions with students differed to affect classroom discourse.

Engineering design activities and conceptual change in middle school science

NASA Astrophysics Data System (ADS)

Schnittka, Christine G.

The purpose of this research was to investigate the impact of engineering design classroom activities on conceptual change in science, and on attitudes toward and knowledge about engineering. Students were given a situated learning context and a rationale for learning science in an active, inquiry-based method, and worked in small collaborative groups. One eighth-grade physical science teacher and her students participated in a unit on heat transfer and thermal energy. One class served as the control while two others received variations of an engineering design treatment. Data were gathered from teacher and student entrance and exit interviews, audio recordings of student dialog during group work, video recordings and observations of all classes, pre- and posttests on science content and engineering attitudes, and artifacts and all assignments completed by students. Qualitative and quantitative data were collected concurrently, but analysis took place in two phases. Qualitative data were analyzed in an ongoing manner so that the researcher could explore emerging theories and trends as the study progressed. These results were compared to and combined with the results of the quantitative data analysis. Analysis of the data was carried out in the interpretive framework of analytic induction. Findings indicated that students overwhelmingly possessed alternative conceptions about heat transfer, thermal energy, and engineering prior to the interventions. While all three classes made statistically significant gains in their knowledge about heat and energy, students in the engineering design class with the targeted demonstrations made the most significant gains over the other two other classes. Engineering attitudes changed significantly in the two classes that received the engineering design intervention. Implications from this study can inform teachers' use of engineering design activities in science classrooms. These implications are: (1) Alternative conceptions will persist when not specifically addressed. (2) Engineering design activities are not enough to promote conceptual change. (3) A middle school teacher can successfully implement an engineering design-based curriculum in a science class. (4) Results may also be of interest to science curriculum developers and engineering educators involved in developing engineering outreach curricula for middle school students.

Differences in short-term memory span of social sciences, science and engineering, and business majors

NASA Astrophysics Data System (ADS)

Khan, Naeem Ullah

This study investigated the difference in the short-term memory span of students of three major groups, namely Social Sciences, Science and Engineering, and Business. This study was designed to answer the following two questions: (1) Is there a difference between short-term memory span, measured by digit span, among the students in or intended for Social Sciences, Science and Engineering, and Business majors? (2) Is there a difference of short-term memory span, measured by word span, among students in or intended for Social Sciences, Science and Engineering, and Business majors? For answering these two questions, inferential and descriptive statistics were used. Analysis of Variance (ANOVA) was used to compare the means of the scores of digit span and word span among the three major groups. The means of digit span and word span among the three groups were compared to find out if a statistically significant difference existed among them or not. The observations were recorded at the level of significance at alpha = .05, and highly significant at alpha = .01. The answer to the first question is yes. The results of this study showed a statistically significant difference in the means of the digit span of the three major groups of students in or intended for Social Sciences, Science and Engineering, and Business. The mean scaled score for digit span was 12.88 for Social Sciences, 14.27 for Science and Engineering, and 15.33 for Business majors, respectively. The means of the free recalls word span of the three groups was 7.23 for Social Sciences, 7.89 for Science and Engineering, and 7.12 for Business majors, respectively. No significant difference was observed in the means of the word span of the three groups. In general observations, it is noted that students want to stay in the subjects or majors in which they can perform well or feel comfortable. In addition to this, students are screened in the school system due to levels of performance or selection pressure. Students' academic performances are dependent on their academic environment and on their inherited construct of short-term and long-term memory span. The use of the memory in certain majors, such as Science and Engineering and Business, are more demanding as compared to Social Science majors. For example, for Science and Engineering majors, students need to memorize complex structures and also need to keep larger information at a stretch in their short-term memory to incorporate it into incoming and outgoing information. Of the other memory related constructs, the present study examined only the short-term memory of the students of different majors, and it was found that the students of the Social Sciences had a shorter digit span as compared to the Science and Engineering and Business majors. Business major students had the largest digit span as compared to the Social Sciences and Science and Engineering majors. This supports the idea that memory construct plays a role in the selection of student majors.

Practical Guidance on Science and Engineering Ethics Education for Instructors and Administrators: Papers and Summary from a Workshop, December 12, 2012

ERIC Educational Resources Information Center

Benya, Frazier F., Ed.; Fletcher, Cameron H.,Ed.; Hollander, Rachelle D.,Ed.

2013-01-01

Over the last two decades, colleges and universities in the United States have significantly increased the formal ethics instruction they provide in science and engineering. Today, science and engineering programs socialize students into the values of scientists and engineers as well as their obligations in the conduct of scientific research and…

Eighth Grade Students Conceptions of How Engineers Use Math and Science in the Field of Engineering: A Comparison of Two Cohorts

ERIC Educational Resources Information Center

Farland-Smith, Donna; Tiarani, Vinta

2016-01-01

Over the last fifteen years, engineering has made its way into science curriculum at all levels, elementary, middle, and high school. A need to analyze students' perception the field of engineering is warranted. Previous techniques for studying representations of scientists and build on what researchers in the science field have learned from…

[Tissue engineering of urinary bladder using acellular matrix].

PubMed

Glybochko, P V; Olefir, Yu V; Alyaev, Yu G; Butnaru, D V; Bezrukov, E A; Chaplenko, A A; Zharikova, T M

2017-04-01

Tissue engineering has become a new promising strategy for repairing damaged organs of the urinary system, including the bladder. The basic idea of tissue engineering is to integrate cellular technology and advanced bio-compatible materials to replace or repair tissues and organs. of the study is the objective reflection of the current trends and advances in tissue engineering of the bladder using acellular matrix through a systematic search of preclinical and clinical studies of interest. Relevant studies, including those on methods of tissue engineering of urinary bladder, was retrieved from multiple databases, including Scopus, Web of Science, PubMed, Embase. The reference lists of the retrieved review articles were analyzed for the presence of the missing relevant publications. In addition, a manual search for registered clinical trials was conducted in clinicaltrials.gov. Following the above search strategy, a total of 77 eligible studies were selected for further analysis. Studies differed in the types of animal models, supporting structures, cells and growth factors. Among those, studies using cell-free matrix were selected for a more detailed analysis. Partial restoration of urothelium layer was observed in most studies where acellular grafts were used for cystoplasty, but no the growth of the muscle layer was observed. This is the main reason why cellular structures are more commonly used in clinical practice.

75 FR 8409 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... have completed bachelor's and master's degrees in science, engineering and health from U.S... on the new entrants into the science and engineering workforce and to provide estimates on the characteristics of recent bachelor's and master's graduates with science, engineering and health degrees. The...

Is Computer Science Compatible with Technological Literacy?

ERIC Educational Resources Information Center

Buckler, Chris; Koperski, Kevin; Loveland, Thomas R.

2018-01-01

Although technology education evolved over time, and pressure increased to infuse more engineering principles and increase links to STEM (science technology, engineering, and mathematics) initiatives, there has never been an official alignment between technology and engineering education and computer science. There is movement at the federal level…

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

An attendee of the USA Science and Engineering Festival uses marbles to build a universe consisting of atoms and dark matter. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

32 CFR 168a.4 - Policy and procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEFENSE SCIENCE AND ENGINEERING GRADUATE FELLOWSHIPS § 168a.4 Policy and procedures. (a) Sponsoring... to pursue graduate degrees in science, engineering, or other fields of study that are designated, in... underrepresented in science and engineering. (3) Without regard to the geographic region in which the applicant...

77 FR 12884 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... colleges, universities, K-12 school systems, businesses, informal science organizations and other research... welfare by supporting research and education in all fields of science and engineering.'' NSF has had a... scientists, engineers, and science and engineering educators. NSF funds research and education in most fields...

32 CFR 168a.4 - Policy and procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... DEFENSE SCIENCE AND ENGINEERING GRADUATE FELLOWSHIPS § 168a.4 Policy and procedures. (a) Sponsoring... to pursue graduate degrees in science, engineering, or other fields of study that are designated, in... underrepresented in science and engineering. (3) Without regard to the geographic region in which the applicant...

32 CFR 168a.4 - Policy and procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DEFENSE SCIENCE AND ENGINEERING GRADUATE FELLOWSHIPS § 168a.4 Policy and procedures. (a) Sponsoring... to pursue graduate degrees in science, engineering, or other fields of study that are designated, in... underrepresented in science and engineering. (3) Without regard to the geographic region in which the applicant...

32 CFR 168a.4 - Policy and procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... DEFENSE SCIENCE AND ENGINEERING GRADUATE FELLOWSHIPS § 168a.4 Policy and procedures. (a) Sponsoring... to pursue graduate degrees in science, engineering, or other fields of study that are designated, in... underrepresented in science and engineering. (3) Without regard to the geographic region in which the applicant...

32 CFR 168a.4 - Policy and procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DEFENSE SCIENCE AND ENGINEERING GRADUATE FELLOWSHIPS § 168a.4 Policy and procedures. (a) Sponsoring... to pursue graduate degrees in science, engineering, or other fields of study that are designated, in... underrepresented in science and engineering. (3) Without regard to the geographic region in which the applicant...

CTE's Role in Science, Technology, Engineering and Mathematics

ERIC Educational Resources Information Center

Hyslop, Alisha

2010-01-01

For the last several years, concern has been brewing about America's underinvestment and underperformance in science, technology, engineering and mathematics--the fields collectively known as STEM. STEM can be described as an initiative for securing America's leadership in science, technology, engineering and mathematics fields and identifying…

Paradigms and progress in vocal fold restoration.

PubMed

Ford, Charles N

2008-09-01

Science advances occur through orderly steps, puzzle-solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem cells, recognition of Helicobacter pylori in the etiology of ulcer disease, and the evolution of species. Our work in vocal fold restoration reflects these patterns. We progressed through phases of tissue replacement with fillers and biological implants, to current efforts at vocal fold regeneration through tissue engineering, and face challenges of a new "systems biology" paradigm embracing genomics and proteomics.

Sense and Sensibility: The Case for the Nationwide Inclusion of Engineering in the K-12 Curriculum

NASA Technical Reports Server (NTRS)

Lindberg, Robert E.; Pinelli, Thomas E.; Batterson, James G.

2008-01-01

The competitive status of the United States is inextricably linked to innovation just as innovation is inseparable from science, technology, engineering, and mathematics. To stay competitive in innovation requires that the United States produce a 21st century workforce complete with requisite education, training, skills, and motivation. If we accept a priori that science, technology, engineering, and mathematics education are crucial to competitiveness and innovation and that, in terms of innovation, mathematics, science, and engineering are interdependent, why are mathematics and science uniformly ubiquitous in the K-12 curriculum while engineering is conspicuously absent? We are passionate in our belief that the uniform addition of engineering to the K-12 curriculum will help ensure that the nation has "the right" 21st Century workforce. Furthermore, we believe that a nationwide effort, led by a coalition of engineering academics, practitioners, and societies is required to turn this goal into reality. However, accomplishing this goal necessitates, as we are reminded by the title of Jane Austen's timeless novel, "Sense and Sensibility", a workable solution that seeks the "middle ground" between passion and reason. We begin our paper by making two essential points: Engineers are not scientists. Engineering exists separate from science, has its own specialized knowledge community apart from science, and it is largely responsible for many of the most significant advancements and improvements in the quality of our life. Our workable solution requires that K-12 education, nationwide, accommodate the inclusion of engineering as a stand alone curriculum and we offer three reasons to support our position: (1) workforce development, (2) stimulating interest in STEM (science, technology, engineering, and mathematics) courses and careers, and (3) creating a technologically literate society. We conclude with some thoughts on how this important goal can be accomplished.

UCS-PROMOVE: The engineer of the future

NASA Astrophysics Data System (ADS)

Villas-Boas, V.

2010-06-01

The Universidade de Caxias do Sul (UCS) elaborated the cooperative project called 'The engineer of the future', with the objective of promoting science and engineering among high school teachers and students. This project aims to improve the quality of the teaching and to increase the interest of students in technological areas, leading to a future career in engineering. The activities of this project were planned to give meaning and foundation to the teaching-learning process of science and for the application of theory in the solution of real problems, while articulating scientific, economic, environmental, social and political aspects and also to reinforce the important role of engineering in society. Amongst the activities to be offered to high school teachers and students are a specialisation course for teachers based upon new educational methodologies, workshops in different areas of science and technology, a programme entitled 'Encouraging girls in technology, science and engineering', science fairs and visits to the industries of the region. Activities with the engineering instructors of UCS are also being developed in order to help them to incorporate in their classes more effective pedagogical strategies for educating the engineer-to-be.

Graduate Enrollment in Science and Engineering Grew Substantially in the Past Decade but Slowed in 2010. InfoBrief. NSF 12-317

ERIC Educational Resources Information Center

Kang, Kelly

2012-01-01

Approximately 632,700 graduate students were enrolled in science, engineering, and health (SEH) programs in the United States as of fall 2010, a 30% increase from approximately 493,300 students in 2000, according to the National Science Foundation's (NSF's) Survey of Graduate Students and Postdoctorates in Science and Engineering (GSS). The growth…

Building a Community of Scholars: One University's Story of Students Engaged in Learning Science, Mathematics, and Engineering through a NSF S-STEM Grant--Part II

ERIC Educational Resources Information Center

Kalevitch, Maria; Maurer, Cheryl; Badger, Paul; Holdan, Greg; Sirinterlikci, Arif

2015-01-01

The School of Engineering, Mathematics, and Science (SEMS) at Robert Morris University (RMU) was awarded a five-year grant from the National Science Foundation (NSF) to fund scholarships to 21 academically talented but financially challenged students majoring in the disciplines of science, technology, engineering, and mathematics (STEM). Each…

Welding As Science: Applying Basic Engineering Principles to the Discipline

NASA Technical Reports Server (NTRS)

Nunes, A. C., Jr.

2010-01-01

This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy.

PubMed

Naderi-Meshkin, Hojjat; Bahrami, Ahmad Reza; Bidkhori, Hamid Reza; Mirahmadi, Mahdi; Ahmadiankia, Naghmeh

2015-01-01

Stem/progenitor cell-based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. For improvement of directed homing of the cells, many techniques have been developed either to engineer stem/progenitor cells with higher amount of chemokine receptors (stem cell-based strategies) or to modulate the target tissues to release higher level of the corresponding chemokines (target tissue-based strategies). This review discusses both of these strategies involved in the improvement of stem cell homing focusing on mesenchymal stem cells as most frequent studied model in cellular therapies. © 2014 International Federation for Cell Biology.

The Biotechnology Facility for International Space Station.

PubMed

Goodwin, Thomas; Lundquist, Charles; Tuxhorn, Jennifer; Hurlbert, Katy

2004-03-01

The primary mission of the Cellular Biotechnology Program is to advance microgravity as a tool in basic and applied cell biology. The microgravity environment can be used to study fundamental principles of cell biology and to achieve specific applications such as tissue engineering. The Biotechnology Facility (BTF) will provide a state-of-the-art facility to perform cellular biotechnology research onboard the International Space Station (ISS). The BTF will support continuous operation, which will allow performance of long-duration experiments and will significantly increase the on-orbit science throughput.

The Biotechnology Facility for International Space Station

NASA Technical Reports Server (NTRS)

Goodwin, Thomas; Lundquist, Charles; Tuxhorn, Jennifer; Hurlbert, Katy

2004-01-01

The primary mission of the Cellular Biotechnology Program is to advance microgravity as a tool in basic and applied cell biology. The microgravity environment can be used to study fundamental principles of cell biology and to achieve specific applications such as tissue engineering. The Biotechnology Facility (BTF) will provide a state-of-the-art facility to perform cellular biotechnology research onboard the International Space Station (ISS). The BTF will support continuous operation, which will allow performance of long-duration experiments and will significantly increase the on-orbit science throughput.

Analysing the integration of engineering in science lessons with the Engineering-Infused Lesson Rubric

NASA Astrophysics Data System (ADS)

Peterman, Karen; Daugherty, Jenny L.; Custer, Rodney L.; Ross, Julia M.

2017-09-01

Science teachers are being called on to incorporate engineering practices into their classrooms. This study explores whether the Engineering-Infused Lesson Rubric, a new rubric designed to target best practices in engineering education, could be used to evaluate the extent to which engineering is infused into online science lessons. Eighty lessons were selected at random from three online repositories, and coded with the rubric. Overall results documented the strengths of existing lessons, as well as many components that teachers might strengthen. In addition, a subset of characteristics was found to distinguish lessons with the highest level of engineering infusion. Findings are discussed in relation to the potential of the rubric to help teachers use research evidence-informed practice generally, and in relation to the new content demands of the U.S. Next Generation Science Standards, in particular.

Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom

PubMed Central

Chen, Weiqiang; Shao, Yue; Li, Xiang; Zhao, Gang; Fu, Jianping

2015-01-01

Summary During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with tissue/organ-specific nanoscale topographical cues to adopt different fates and functions. Attributed to their capability of self-renewal and differentiation into most types of somatic cells, stem cells also hold tremendous promise for regenerative medicine and drug screening. However, a major challenge remains as to achieve fate control of stem cells in vitro with high specificity and yield. Recent exciting advances in nanotechnology and materials science have enabled versatile, robust, and large-scale stem cell engineering in vitro through developments of synthetic nanotopographical surfaces mimicking topological features of stem cell niches. In addition to generating new insights for stem cell biology and embryonic development, this effort opens up unlimited opportunities for innovations in stem cell-based applications. This review is therefore to provide a summary of recent progress along this research direction, with perspectives focusing on emerging methods for generating nanotopographical surfaces and their applications in stem cell research. Furthermore, we provide a review of classical as well as emerging cellular mechano-sensing and -transduction mechanisms underlying stem cell nanotopography sensitivity and also give some hypotheses in regard to how a multitude of signaling events in cellular mechanotransduction may converge and be integrated into core pathways controlling stem cell fate in response to extracellular nanotopography. PMID:25883674

STEM: Science Technology Engineering Mathematics

ERIC Educational Resources Information Center

Carnevale, Anthony P.; Smith, Nicole; Melton, Michelle

2011-01-01

The generative economic power and social influence of Science, Technology, Engineering, and Mathematics (STEM) has made the production of a capable science and engineering workforce a priority among business and policy leaders. They are rightly concerned that without a robust STEM workforce, the nation will become less competitive in the global…

Shaking up Pre-Calculus: Incorporating Engineering into K-12 Curricula

ERIC Educational Resources Information Center

Sabo, Chelsea; Burrows, Andrea; Childers, Lois

2014-01-01

Projects highlighting Science, Technology, Engineering, and Mathematics (STEM) education in high schools have promoted student interest in engineering-related fields and enhanced student understanding of mathematics and science concepts. The Science and Technology Enhancement Program (Project STEP), funded by a NSF GK-12 grant at the University of…

75 FR 8408 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... earned a research doctoral degree in a science, engineering or health field from a U.S. institution. The... estimates on the doctoral science and engineering workforce and changes in their employment, education and... nation's science and engineering workforce. The 2010 SDR will provide necessary input into the SESTAT...

77 FR 32699 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... earned a research doctoral degree in a science, engineering or health field from a U.S. institution. The... estimates on the doctoral science and engineering workforce and changes in their employment, education and... nation's science and engineering workforce. The 2013 SDR will provide necessary input into the SESTAT...

Linus Pauling Memorial Lectures

Science.gov Websites

Institute for Science, Engineering and Public Policy Home About The Institute Format/Policy Pauling Memorial Lectures Science, Engineering and Public Policy 2017-2018 Sabbatical Year Taking a Year Physics to the New Philosophy Terry Bristol Institute for Science, Engineering and Public Policy 7:00pm

Evaluation of the Alaska Native Science & Engineering Program (ANSEP). Research Report

ERIC Educational Resources Information Center

Bernstein, Hamutal; Martin, Carlos; Eyster, Lauren; Anderson, Theresa; Owen, Stephanie; Martin-Caughey, Amanda

2015-01-01

The Urban Institute conducted an implementation and participant-outcomes evaluation of the Alaska Native Science & Engineering Program (ANSEP). ANSEP is a multi-stage initiative designed to prepare and support Alaska Native students from middle school through graduate school to succeed in science, technology, engineering, and math (STEM)…

Degree Attainment. Snapshot™ Report, Winter 2015

ERIC Educational Resources Information Center

National Student Clearinghouse, 2015

2015-01-01

This Snapshot Report presents information on student degree attainment in science and engineering disciplines for 2004 and 2014. It offers data on the following: (1) Science and Engineering Degrees as Percentage of All Degrees; (2) Gender Distribution of Science and Engineering Degrees by Level; (3) Gender Distribution of Bachelor's Degrees in…

Leading Practice in Space Education: Successful Approaches by Specialist Schools

ERIC Educational Resources Information Center

Schools Network, 2010

2010-01-01

The aim of the Government's Science, Technology, Engineering and Mathematics (STEM) programme is to ensure Britain's future success as a major centre for science, engineering and innovation. Specialist science, technology, engineering and maths & computing colleges help to drive this programme by becoming centres of excellence in STEM…

Colloquy on Minority Males in Science, Technology, Engineering, and Mathematics

ERIC Educational Resources Information Center

Didion, Catherine; Fortenberry, Norman L.; Cady, Elizabeth

2012-01-01

On August 8-12, 2010 the National Academy of Engineering (NAE), with funding from the National Science Foundation (NSF), convened the Colloquy on Minority Males in Science, Technology, Engineering, and Mathematics (STEM), following the release of several reports highlighting the educational challenges facing minority males. The NSF recognized the…

Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and

Science.gov Websites

Thermal Engineering Sciences | NREL Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and Thermal Engineering Sciences Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and Thermal Engineering Sciences A photo of Johney Green In his role, Johney Green oversees early

Science and Engineering Programs: On Target for Women?

ERIC Educational Resources Information Center

Matyas, Marsha Lakes, Ed.; Dix, Linda Skidmore, Ed.

To increase women's participation in science and engineering, many barriers must be overcome. This book, an outcome of a conference held by the National Research Council's Committee on Women in Science and Engineering, summarizes presentations of many experts and presents information on specific strategies for increasing the participation of women…

1996 Laboratory directed research and development annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyers, C.E.; Harvey, C.L.; Lopez-Andreas, L.M.

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms.

Mapping Engineering Concepts for Secondary Level Education. Final Report. Research in Engineering and Technology Education

ERIC Educational Resources Information Center

Daugherty, Jenny L.

2011-01-01

Much of the national attention on science, technology, engineering, and mathematics (STEM) education tends to concentrate on science and mathematics, with its emphasis on standardized test scores. However as the National Academy of Engineering Committee on K-12 Engineering Education stressed, engineering can contribute to the development of an…

Sandia National Laboratories: About Sandia: Community Involvement:

Science.gov Websites

DOE Regional Science Bowls - New Mexico DOE Regional Science Bowls - California Family Math Night Family Science Night Science, Technology, Engineering, and Math Programs About Education Programs a national concern. Encouraging students to pursue science, technology, engineering, and math (STEM

77 FR 61448 - Nanoscale Science, Engineering and Technology Subcommittee Committee on Technology, National...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering and Technology Subcommittee Committee on Technology, National Science and Technology Council; Public Meetings AGENCY: Executive Office of the President, Office of Science and Technology Policy. ACTION: Notice of Public Meetings. SUMMARY...

Teaching Engineering Practices

NASA Astrophysics Data System (ADS)

Cunningham, Christine M.; Carlsen, William S.

2014-03-01

Engineering is featured prominently in the Next Generation Science Standards (NGSS) and related reform documents, but how its nature and methods are described is problematic. This paper is a systematic review and critique of that representation, and proposes that the disciplinary core ideas of engineering (as described in the NGSS) can be disregarded safely if the practices of engineering are better articulated and modeled through student engagement in engineering projects. A clearer distinction between science and engineering practices is outlined, and prior research is described that suggests that precollege engineering design can strengthen children's understandings about scientific concepts. However, a piecemeal approach to teaching engineering practices is unlikely to result in students understanding engineering as a discipline. The implications for science teacher education are supplemented with lessons learned from a number of engineering education professional development projects.

Integrating Engineering into Delaware's K-5 Classrooms: A Study of Pedagogical and Curricular Resources

NASA Astrophysics Data System (ADS)

Grusenmeyer, Linda Huey

This study examines the personal and curricular resources available to Delaware's elementary teachers during a time of innovative curriculum change, i.e., their knowledge, goals and beliefs regarding elementary engineering curriculum and the pedagogical support to teach two Science and Engineering Practices provided by science teaching materials. Delaware was at the forefront of K-12 STEM movement, first to adopt statewide elementary curriculum materials to complement existing science units, and one of the first to adopt the new science standards--Next Generation Science Standards. What supports were available to teachers as they adapted and adopted this new curriculum? To investigate this question, I examined (1) teachers' beliefs about engineering and the engineering curriculum, and (2) the pedagogical supports available to teachers in selected science and engineering curriculum. Teachers' knowledge, goals, and beliefs regarding Delaware's adoption of new elementary engineering curriculum were surveyed using an adapted version of the Design, Engineering, and Technology Survey (Hong, Purser, & Gardella, 2011; Yaser, Baker, Carpius, Krauss, & Roberts, 2006). Also, three open ended questions sought to reveal deeper understanding of teacher knowledge and understanding of engineering; their concerns about personal and systemic resources related to the new curriculum, its logistics, and feasibility; and their beliefs about the potential positive impact presented by the engineering education initiative. Teacher concerns were analyzed using the Concerns-Based Adoption Model (Hall & Hord, 2010). Lay understandings of engineering were analyzed by contrasting naive representations of engineering with three key characteristics of engineering adapted from an earlier study (Capobianco Diefes-Dux, Mena, & Weller, 2011). Survey findings for teachers who had attended training and those who have not yet attended professional development in the new curriculum were compared with few notable differences. Almost all elementary teacher respondents were familiar with engineering and able to define it using one or more key characteristics. They valued the inclusion of engineering in the elementary curriculum; however trained and untrained teachers reported they were not confident about teaching it and were unaware of the new standards related to engineering. Teachers saw potential advantages or benefits of the new curriculum as helping improve science and math understanding, an opportunity to increase vocational awareness, and engaging students and motivating them to learn. Most teachers saw similar barriers to implementation- lack of teacher knowledge, lack of time to learn about engineering and how to teach engineering, and lack of administrative support. Almost all were open to additional in-service training to learn more about this new curriculum. Three fifth grade science units were examined for evidence of teacher pedagogical support in teaching two Science and Engineering Practices (SEP) advocated by the Next Generation Science Standards. An analytic framework was developed based upon two NGSS SEPs: Asking questions, defining problems and Engaging in argument from evidence. Findings revealed that the kits varied greatly in their pedagogical approaches to the two SEPs and differences might be explained by each kit's underlying orientations to the teaching-learning process. Findings from these investigations have implications for the design of professional development and for engineering curricula. They highlight the importance of considering teacher beliefs about curriculum implementation and subject matter, as well as the importance of creating curriculum materials that focus teacher attention toward student thinking and the language rich science and engineering practices. Recommendations also include ongoing professional development to allow teachers time to try out and revise pedagogical routines that support the SEPs studied here.

The International Congress of Mechanical Engineering and Agricultural Sciences - CIIMCA 2013

NASA Astrophysics Data System (ADS)

Remolina-Millán, Aduljay; Hernández-Arroyo, Emil

2014-06-01

The organizing committee of The International Congress of Mechanical Engineering and Agricultural Sciences - CIIMCA 2013 - are pleased to present CIIMCA-2013: the first international conference focused on subjects of materials science, mechanical engineering and renewable energy organized by Mechanical Engineering Faculty of the ''Universidad Pontificia Bolivariana'' in Bucaramanga, Colombia. This conference aims to be a place to produce discussions on whole topics of the congress, between the scientists of Colombia and the world. We strongly believe that knowledge is fundamental to the development of our countries. For that reason this multidisciplinary conference is looking forward to integrate engineering, agricultural science and nanoscience and nanotechnology to produce a synergy of this area of knowledge and to achieve scientific and technological developments. Agriculture is a very important topic for our conference; in Colombia, agricultural science needs more attention from the scientific community and the government. In the Faculty of Mechanical Engineering we are beginning to work on these issues to produce knowledge and improve the conditions in our country. The CIIMCA conference is a great opportunity to create interpersonal relationships and networks between scientists around the world. The interaction between scientists is very important in the process of the construction of knowledge. The general chairman encourages and invites you to make friends, relationships and participate strongly in the symposia and all program activities. PhD Aduljay Remolina-Millán Principal Chairman, International Mechanical Engineering and Agricultural Sciences Congress - CIIMCA Msc Emil Hernández-Arroyo Principal Chairman, International Mechanical Engineering and Agricultural Sciences Congress - CIIMCA Conference photograph Conference photograph 'Universidad Pontificia Bolivariana seccional Bucaramanga' host of the first International Mechanical Engineering and Agricultural Sciences Congress - CIIMCA 2013 - Floridablanaca, Colombia. Conference photograph Closure of CIIMCA 2013. Details of the editorial committee and acknowledgements are available in the PDF.

S.E.E.ing the Future: Science, Engineering and Education. Commentary from the Scientific Grassroots. A White Paper on the Issues and Need for Public Funding of Basic Science and Engineering Research.

ERIC Educational Resources Information Center

Jemison, Mae C., Ed.

This document reports on the results of an ad hoc workshop called "S.E.E.ing the Future: Science Engineering and Education" Held at Dartmouth College in November of 2000 and sponsored by Dartmouth, the National Science Foundation, the Dow Chemical Company, and Science Service of Washington, DC. This transdisciplinary conference was one of a series…

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances.

PubMed

Derakhshanfar, Soroosh; Mbeleck, Rene; Xu, Kaige; Zhang, Xingying; Zhong, Wen; Xing, Malcolm

2018-06-01

3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.

Biocompatible Nanomaterials and Nanodevices Promising for Biomedical Applications

NASA Astrophysics Data System (ADS)

Firkowska, Izabela; Giannona, Suna; Rojas-Chapana, José A.; Luecke, Klaus; Brüstle, Oliver; Giersig, Michael

Nanotechnology applied to biology requires a thorough understanding of how molecules, sub-cellular entities, cells, tissues, and organs function and how they are structured. The merging of nanomaterials and life science into hybrids of controlled organization and function is possible, assuming that biology is nanostructured, and therefore man-made nano-materials can structurally mimic nature and complement each other. By taking advantage of their special properties, nanomaterials can stimulate, respond to and interact with target cells and tissues in controlled ways to induce desired physiological responses with a minimum of undesirable effects. To fulfill this goal the fabrication of nano-engineered materials and devices has to consider the design of natural systems. Thus, engineered micro-nano-featured systems can be applied to biology and biomedicine to enable new functionalities and new devices. These include, among others, nanostructured implants providing many advantages over existing, conventional ones, nanodevices for cell manipulation, and nanosensors that would provide reliable information on biological processes and functions.

On the road to bioartificial organs.

PubMed

Ren, X; Ott, H C

2014-10-01

Biological organs are highly orchestrated systems with well-coordinated positioning, grouping, and interaction of different cell types within their specialized extracellular environment. Bioartificial organs are intended to be functional replacements of native organs generated through bioengineering techniques and hold the potential to alleviate donor organ shortage for transplantation. The development, production, and evaluation of such bioartificial organs require synergistic efforts of biology, material science, engineering, and medicine. In this review, we highlight the emerging platforms enabling structured assembly of multiple cell types into functional grafts and discuss recent advances and challenges in the development of bioartificial organs, including cell sources, in vitro organ culture, in vivo evaluation, and clinical considerations.

Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW).

PubMed

Shi, Jinjie; Ahmed, Daniel; Mao, Xiaole; Lin, Sz-Chin Steven; Lawit, Aitan; Huang, Tony Jun

2009-10-21

Here we present an active patterning technique named "acoustic tweezers" that utilizes standing surface acoustic wave (SSAW) to manipulate and pattern cells and microparticles. This technique is capable of patterning cells and microparticles regardless of shape, size, charge or polarity. Its power intensity, approximately 5x10(5) times lower than that of optical tweezers, compares favorably with those of other active patterning methods. Flow cytometry studies have revealed it to be non-invasive. The aforementioned advantages, along with this technique's simple design and ability to be miniaturized, render the "acoustic tweezers" technique a promising tool for various applications in biology, chemistry, engineering, and materials science.

First-year engineering students' views of the nature of engineering

NASA Astrophysics Data System (ADS)

Karatas, Faik O.

The changing nature of engineering problems and new challenges that result from globalization and new ways of doing business have triggered calls for a revolutionary shift in engineering education. To respond to these challenges, the engineering education paradigm has been revised by adding more design and humanities/social sciences components to it. Philosophy, sociology, and history of engineering are more often cited as a major part of engineering education in this movement. Research on the nature of engineering (NOE), which is derived from philosophy, sociology, and the history of engineering, could have as much potential impact on engineering education as research on the nature of science (NOS) has had on science education. Thus, it is surprising that there has been no noteworthy research on this topic. The purpose of this study is to describe and determine first-year engineering students' views of the NOE and how these students differentiate engineering from science. In this research, an open-ended Views of the Nature of Engineering questionnaire (VNOE) was employed to collect baseline data. Semi-structured interviews based on the VNOE questionnaire were conducted with the second cohort of the participants. Data analysis was guided by a traditional phenomenographic approach, which is a branch of the hermeneutic tradition, coupled to constant comparison technique. The results of this study indicated that the participants' overall views of the nature of engineering were not ill-developed, but rather unarticulated. Moreover, the relationship between engineering and science was considered unidirectional rather than bidirectional. The results of this study could be used to inform engineering educators, first-year engineering coordinators, and policy makers as well as serving as the base for further research and potential implications for future first-year and K-12 engineering education.

Engineering education in Bangladesh - an indicator of economic development

NASA Astrophysics Data System (ADS)

Chowdhury, Harun; Alam, Firoz

2012-05-01

Developing nations including Bangladesh are significantly lagging behind the millennium development target due to the lack of science, technology and engineering education. Bangladesh as a least developing country has only 44 engineers per million people. Its technological education and gross domestic product growth are not collinear. Although limited progress was made in humanities, basic sciences, agriculture and medical sciences, a vast gap is left in technical and engineering education. This paper describes the present condition of engineering education in the country and explores ways to improve engineering education in order to meet the national as well as global skills demand.

Emotion-on-a-chip (EOC): evolution of biochip technology to measure human emotion using body fluids.

PubMed

Lee, Jung-Hyun; Hwang, Yoosun; Cheon, Keun-Ah; Jung, Hyo-Il

2012-12-01

Recent developments in nano/micro technology have made it possible to construct small-scale sensing chips for the analysis of biological markers such as nucleic acids, proteins, small molecules, and cells. Although biochip technology for the diagnosis of severe physiological diseases (e.g., cancer, diabetes, and cardiovascular disease) has been extensively studied, biochips for the monitoring of human emotions such as stress, fear, depression, and sorrow have not yet been introduced, and the development of such a biochip is in its infancy. Emotion science (or affective engineering) is a rapidly expanding engineering/scientific discipline that has a major impact on human society. The growing interest in the integration of emotion science and engineering is a result of the recent trend of merging various academic fields. In this paper we discuss the potential importance of biochip technology in which human emotion can be precisely measured in real time using body fluids such as blood, saliva, urine, or sweat. We call these biochips emotion-on-a-chip (EOC). The EOC system consists of four parts: (1) collection of body fluids, (2) separation of emotional markers, (3) detection of optical or electrical signals, and (4) display of results. These techniques provide new opportunities to precisely investigate human emotion. Future developments in EOC techniques will combine social and natural sciences to expand their scope of study. Copyright © 2012 Elsevier Ltd. All rights reserved.

Urban Elementary STEM Initiative

ERIC Educational Resources Information Center

Parker, Carolyn; Abel, Yolanda; Denisova, Ekaterina

2015-01-01

The new standards for K-12 science education suggest that student learning should be more integrated and should focus on crosscutting concepts and core ideas from the areas of physical science, life science, Earth/space science, and engineering/technology. This paper describes large-scale, urban elementary-focused science, technology, engineering,…

78 FR 24241 - Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National Science and Technology Council; Notice of Public Meeting AGENCY: Executive Office of the President, Office of Science and Technology Policy. ACTION: Notice of Public Meeting...

Female and male Hispanic students majoring in science or engineering: Their stories describing their educational journeys

NASA Astrophysics Data System (ADS)

Brown, Susan Wightman

National statistics clearly demonstrate an underrepresentation of minorities in the fields of science and engineering. Blacks, Hispanics, American Indians, and Asians do not typically choose science or engineering as their college major; therefore, there is a very small representation of these minorities in the science and engineering labor force. The decision not to major in science and engineering may begin as soon as the child can begin to recognize role models in the media. News stories, magazine articles, television programs, teachers, parents, administrators, and other agencies have painted the picture of a scientist or engineer as being dominantly a White male. Schools have continued society's portrayal by using curriculum, textbooks, role models, instructional strategies, and counseling that continues to encourage the White male to succeed in science and engineering, but discourages the minority students, male and female, from succeeding in these fields. In this qualitative study, 22 Hispanic students, 12 female and 10 male, who are majoring in science or engineering, were interviewed using Seidman's in-depth interviewing technique. These students were shadowed in their college science or engineering classes; their high school and college transcripts were analyzed; and, a focus group was brought together at the end of the interviewing process in order to allow interaction between the participants. The goal was to explore the educational journeys of the 22 Hispanic students. What made a difference in the journeys of these 22 students so that they could succeed in majors that have historically discouraged minority students? Seven themes emerged: family support, honors program, challenging and interactive curriculum, college preparation in high school courses, caring and kind teachers, small class size, and small communities. Gender comparison of the educational journeys documents these differences between the females and males: college preparation, mentoring, special school and summer programs, and gender role conflicts. In Chapter Six, a picture is painted by these 22 Hispanic students of a school that would promote success for all minority students in science and engineering related classes. Science and math educators, and really all educators, should take note and changes need to be made in our schools in order to provide a learning environment for all students.

Mother, Earth, Father Sky Symposium

NASA Technical Reports Server (NTRS)

Bowman, B.

1977-01-01

A conference was held in which minority aerospace scientists and engineers interacted with the minority community, particularly at the junior high, high school, and college levels. There were two presentations in the biological sciences, two in the physical and environmental sciences, seven in engineering and computer sciences, and nine in aerospace science and engineering. Aerospace technology careers and aerospace activities were discussed as to how they are relevant to minorities and women.

Training in Methods in Computational Neuroscience

DTIC Science & Technology

1989-11-14

inferior colliculus served as inputs to a sheet of 100 cells within the medial geniculate body where combination sensitivity is first observed. Inputs from...course is for advanced graduate students and postdoctoral fellows in neurobiology , physics, electrical engineering, computer science and psychology...Research Code 1142BI 800 N. Quincy St Arlington, VA 22217-5000 Paul Adams Department of Neurobiology SUNY, Stony Brook Graduate Biology Building 576

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voigt, Christopher

SEED2014 focused on advances in the science and technology emerging from the field of synthetic biology. We broadly define this as technologies that accelerate the process of genetic engineering. It highlighted new tool development, as well as the application of these tools to diverse problems in biotechnology, including therapeutics, industrial chemicals and fuels, natural products, and agriculture. Systems spanned from in vitro experiments and viruses, through diverse bacteria, to eukaryotes (yeast, mammalian cells, plants).

Embryonic and Induced Pluripotent Stem Cells: Understanding, Creating, and Exploiting the Nano-Niche for Regenerative Medicine

PubMed Central

2013-01-01

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. As nanoscale science and engineering continues to produce novel nanotechnology platforms, which inform, infiltrate, and impinge on many aspects of everyday life, it is no surprise that stem cell research is turning toward developments in nanotechnology to answer research questions and to overcome obstacles in regenerative medicine. Here we discuss recent advances in ESC and iPSC manipulation using nanomaterials and highlight future challenges within this area of research. PMID:23414366

Modeling Sources of Teaching Self-Efficacy for Science, Technology, Engineering, and Mathematics Graduate Teaching Assistants.

PubMed

DeChenne, Sue Ellen; Koziol, Natalie; Needham, Mark; Enochs, Larry

2015-01-01

Graduate teaching assistants (GTAs) in science, technology, engineering, and mathematics (STEM) have a large impact on undergraduate instruction but are often poorly prepared to teach. Teaching self-efficacy, an instructor's belief in his or her ability to teach specific student populations a specific subject, is an important predictor of teaching skill and student achievement. A model of sources of teaching self-efficacy is developed from the GTA literature. This model indicates that teaching experience, departmental teaching climate (including peer and supervisor relationships), and GTA professional development (PD) can act as sources of teaching self-efficacy. The model is pilot tested with 128 GTAs from nine different STEM departments at a midsized research university. Structural equation modeling reveals that K-12 teaching experience, hours and perceived quality of GTA PD, and perception of the departmental facilitating environment are significant factors that explain 32% of the variance in the teaching self-efficacy of STEM GTAs. This model highlights the important contributions of the departmental environment and GTA PD in the development of teaching self-efficacy for STEM GTAs. © 2015 S. E. DeChenne et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Beyond access to transformations: A cross-national analysis of women in science and engineering education, 1970--2000

NASA Astrophysics Data System (ADS)

Wotipka, Christine Min

2001-12-01

Over the years, attention to the issue of women in science has tended to focus on individual and organizational efforts to encourage women's greater participation in science and engineering fields of study and occupations. With more intense globalization processes that increasingly shape and are shaped by science, national- and global-level understandings of the situation of women in science and engineering as well as methods to boost their greater and more equal participation in these fields are necessary. This study is a cross-national and longitudinal study of women's participation in science and engineering fields of study at the higher education level. In order to explain the growth in women's participation in these fields of study between 1972--1992, I use a world society theoretical perspective to argue that national linkages to global models regarding women's educational equality and women in science may positively influence their participation in these fields. In multivariate statistical analyses, women's participation in higher education, measured as female enrollment in non-science and non-engineering fields of study, exerted a positive effect on women in science and engineering as did male enrollment in science and engineering higher education. The fact that linkage variables and those measuring women's status and other national-level factors were not found to be influential suggests that world-level factors may be contributing to women's greater participation in these fields. To better understand processes at this level, I use feminist critiques of science to examine the efforts made by the United Nations Educational, Scientific, and Cultural Organization (UNESCO), the United Nations Children's Fund (UNICEF), and the World Bank to address women in science and engineering education over a thirty year time period. My examination of their publications as well as conference declarations and platforms of action from ten international conferences finds a reliance on liberal feminist suggestions such as access and equal opportunities for women in science. More recently, UNESCO publications have included some transformative perspectives that entail possibilities for the inclusion of women's needs and interests into the existing male-dominated scientific curricula and structures. The same is true of some of the most recent international conferences.

University of Illinois at Urbana-Champaign, Materials Research Laboratory progress report for FY 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-07-01

This interdisciplinary laboratory in the College of Engineering support research in areas of condensed matter physics, solid state chemistry, and materials science. These research programs are developed with the assistance of faculty, students, and research associates in the departments of Physics, Materials Science and Engineering, chemistry, Chemical Engineering, Electrical Engineering, Mechanical Engineering, and Nuclear Engineering.

Engineering Outreach: A Successful Initiative with Gifted Students in Science and Technology in Hong Kong

ERIC Educational Resources Information Center

Chan, Yuen-Yan; Hui, Diane; Dickinson, Anthony R.; Chu, Dennis; Cheng, David Ki-Wai; Cheung, Edward; Ki, Wing-Hung; Lau, Wing-Hong; Wong, Jasper; Lo, Edward W. C.; Luk, Kwai-Man

2010-01-01

The primary goal of engineering outreach is to attract prospective students to engineering education and the engineering profession. Gifted students, especially those identified as possessing unusually high abilities in science and technology, are especially promising students to attract to careers in engineering. It is critical to cultivate these…

Breaking It Down: Engineering Student STEM Confidence at the Intersection of Race/Ethnicity and Gender

ERIC Educational Resources Information Center

Litzler, Elizabeth; Samuelson, Cate C.; Lorah, Julie A.

2014-01-01

It is generally accepted that engineering requires a strong aptitude for mathematics and science; therefore, students' judgments regarding their competence in these areas as well as engineering likely influence their confidence in engineering. Little is known about how self-confidence in science, mathematics, and engineering courses (STEM…

Engineering in K-12 Education: Understanding the Status and Improving the Prospects

ERIC Educational Resources Information Center

Katehi, Linda, Ed.; Pearson, Greg, Ed.; Feder, Michael, Ed.

2009-01-01

Engineering education in K-12 classrooms is a small but growing phenomenon that may have implications for engineering and also for the other STEM subjects--science, technology, and mathematics. Specifically, engineering education may improve student learning and achievement in science and mathematics, increase awareness of engineering and the work…

Exploring Complex Engineering Learning over Time with Epistemic Network Analysis

ERIC Educational Resources Information Center

Svarovsky, Gina Navoa

2011-01-01

Recently, K-12 engineering education has received increased attention as a pathway to building stronger foundations in math and science and introducing young people to the profession. However, the National Academy of Engineering found that many K-12 engineering programs focus heavily on engineering design and science and math learning while…

Development of a Leadership, Policy, and Change Course for Science, Technology, Engineering, and Mathematics Graduate Students

ERIC Educational Resources Information Center

Cox, Monica F.; Berry, Carlotta A.; Smith, Karl A.

2009-01-01

This paper describes a graduate level engineering education course, "Leadership, Policy, and Change in Science, Technology, Engineering, and Mathematics (STEM) Education." Offered for the first time in 2007, the course integrated the perspectives of three instructors representing disciplines of engineering, education, and engineering education.…

Economically Disadvantaged Minority Girls' Knowledge and Perceptions of Science and Engineering and Related Careers

ERIC Educational Resources Information Center

Wang, Hui-Hui; Billington, Barbara L.

2016-01-01

This article addresses economically disadvantaged minority girls' knowledge and perceptions of science and engineering and the influence of their experiences with science, technology, engineering, and mathematics (STEM) on their choices for future careers. We interviewed three girls who participated in a 4-H-led gender-inclusive STEM program. Our…

JPRS Report, Science & Technology, Europe & Latin America

DTIC Science & Technology

1988-04-06

courses and in polytechnics a growing number of undergraduate research theses [ tesi di laurea] are increasingly coming to resemble authentic feasibility...Information Science Eleven Priorities Research Priority Actions — Microbiological engineering —Enzyme engineering —Biotechnological engineering —Food...Foodstuffs Medicine Human and social sciences Technology, computer-integrated manufacturing Electronics, data processing Microbiological

Manpower and Financial Resources Allocated to Academic Science and Engineering Activities, 1965-71.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

This report summarizes the results of the National Science Foundation's biennial survey of manpower and financial resources for scientific engineering activities at institutions of higher education, 1971. The survey was conducted by mail questionnaires sent to 2,198 universities and colleges that maintained science and engineering programs, and…

Electrical Engineering | Classification | College of Engineering & Applied

Science.gov Websites

) 229-6916bsra@uwm.eduEng & Math Sciences 995 profile photo Robert Cuzner, Ph.D.Assistant ChairDepartment Chair of Electrical Engineering(414) 229-3885george@uwm.eduEng & Math Sciences 1245 profile photo Hossein Hosseini, Ph.D.ProfessorComputer Science(414) 229-5184hosseini@uwm.eduEng & Math

Biomedical Engineering and Cognitive Science Secondary Science Curriculum Development: A Three Year Study

ERIC Educational Resources Information Center

Klein, Stacy S.; Sherwood, Robert D.

2005-01-01

This study reports on a multi-year effort to create and evaluate cognitive-based curricular materials for secondary school science classrooms. A team of secondary teachers, educational researchers, and academic biomedical engineers developed a series of curriculum units that are based in biomedical engineering for secondary level students in…

Women, Minorities, and Persons with Disabilities in Science and Engineering: 2009. NSF 09-305

ERIC Educational Resources Information Center

National Science Foundation, 2009

2009-01-01

"Women, Minorities, and Persons with Disabilities in Science and Engineering" provides statistical information about the participation of women, minorities, and persons with disabilities in science and engineering education and employment. Its primary purpose is to serve as an information source; it offers no endorsement of or recommendations…

E-Laboratory Design and Implementation for Enhanced Science, Technology and Engineering Education

ERIC Educational Resources Information Center

Morton, William; Uhomoibhi, James

2011-01-01

Purpose: This paper aims to report on the design and implementation of an e-laboratory for enhanced science, technology and engineering education studies. Design/methodology/approach: The paper assesses a computer-based e-laboratory, designed for new entrants to science, technology and engineering programmes of study in further and higher…

Primary School Students' Views about Science, Technology and Engineering

ERIC Educational Resources Information Center

Pekmez, Esin

2018-01-01

Some of the main goals of science education are to increase students' knowledge about the technology and engineering design process, and to train students as scientifically and technologically literate individuals. The main purpose of this study is to find out primary students' views about science, technology and engineering. For this aim and in…

Embedding Enterprise in Science and Engineering Departments

ERIC Educational Resources Information Center

Handscombe, Robert D.; Rodriguez-Falcon, Elena; Patterson, Eann A.

2008-01-01

Purpose: This paper aims to focus on the attempts to implement the challenges of teaching enterprise to science and engineering students by the embedding approach chosen by the White Rose Centre for Enterprise (WRCE), one of the centres formed under the Science Engineering Challenge in the UK. Design/methodology/approach: WRCE's objective was to…

Gender Differences at Critical Transitions in the Careers of Science, Engineering, and Mathematics Faculty

ERIC Educational Resources Information Center

National Academies Press, 2010

2010-01-01

"Gender Differences at Critical Transitions in the Careers of Science, Engineering, and Mathematics Faculty" presents new and surprising findings about career differences between female and male full-time, tenure-track, and tenured faculty in science, engineering, and mathematics at the nation's top research universities. Much of this…

Measurement System for Energetic Materials Decomposition

DTIC Science & Technology

2015-01-05

scholarships or fellowships for further studies in science, mathematics, engineering or technology fields: Student Metrics This section only applies to...science, mathematics, engineering, or technology fields: The number of undergraduates funded by your agreement who graduated during this period and...will continue to pursue a graduate or Ph.D. degree in science, mathematics, engineering, or technology fields

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

A NASA staff member shows attendees of the USA Science and Engineering Festival what happens to the human body in space without a space suit using a marshmallow bunny. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

The Science of Safety

ERIC Educational Resources Information Center

Jensen, Jill

2012-01-01

The author's first reaction to learning that the new science standards adopted in Minnesota included engineering was fear and apprehension. She couldn't picture what an engineering project would look like at the elementary level. As a K-5 elementary science specialist, it was now her job to figure out how to incorporate engineering in their…

Explaining Variation in Student Efforts towards Using Math and Science Knowledge in Engineering Contexts

ERIC Educational Resources Information Center

Berland, Leema K.; Steingut, Rebecca

2016-01-01

Previous research suggests that in classes that take an integrated approach to science, technology, engineering, and math (STEM) education, students tend to engage in fulfilling goals of their engineering design challenges, but only inconsistently engage with the related math and science content. The present research examines these inconsistencies…

What Attracts High-Achieving Socioeconomically Disadvantaged Students to the Physical Sciences and Engineering?

ERIC Educational Resources Information Center

Conrad, Sarah; Canetto, Silvia Sara; MacPhee, David; Farro, Samantha

2009-01-01

Socioeconomically disadvantaged (SED) students are less likely to major in physical sciences or engineering. To guide recruitment and retention of a diversity of talent, this study examined what attracts high-achieving SED students to these fields. Participants were 50 undergraduates majoring in physical sciences or engineering enrolled in the…

Science and Engineering Technician Curriculum Development Project. Final Report.

ERIC Educational Resources Information Center

Mowery, Donald R.; Wolf, Lawrence J.

Project SET (Science and Engineering for Technicians) developed a series of study guides designed to teach generic science and engineering skills to students interested in becoming technicians. An entire 2-year curriculum is encompassed by these guides, geared for 2-year college students. Described in this final report are the project's rationale,…

Science and Engineering Indicators 2010. NSB 10-01

ERIC Educational Resources Information Center

Lehming, Rolf F.; Alt, Martha Naomi; Chen, Xianglei; Hall, Leslie; Burton, Lawrence; Burrelli, Joan S.; Kannankutty, Nirmala; Proudfoot, Steven; Regets, Mark C.; Boroush, Mark; Moris, Francisco A.; Wolfe, Raymond M.; Britt, Ronda; Christovich, Leslie; Hill, Derek; Falkenheim, Jaquelina C.; Dunnigan, Paula C.

2010-01-01

"Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising the major high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI is factual and policy neutral. It does not offer policy options, and it does not make policy recommendations. SEI employs a variety…

Science and Engineering Indicators 2012. NSB 12-01

ERIC Educational Resources Information Center

National Science Foundation, 2012

2012-01-01

Science and Engineering Indicators (SEI) is first and foremost a volume of record comprising the major high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI is factual and policy neutral. It does not offer policy options, and it does not make policy recommendations. SEI employs a variety of…

International Doctoral Science and Engineering Students: Impact on Cohorts' Career Prospects

ERIC Educational Resources Information Center

Su, Xuhong

2013-01-01

As more international doctoral students flow into science and engineering departments in American research universities, a marked shift on the demographic composition of doctoral student bodies has been witnessed. Using a dataset combining a survey of science and engineering department chairs with the latest department evaluation information, this…

Engineering Design Activities and Conceptual Change in Middle School Science

ERIC Educational Resources Information Center

Schnittka, Christine G.

2009-01-01

The purpose of this research was to investigate the impact of engineering design classroom activities on conceptual change in science, and on attitudes toward and knowledge about engineering. Students were given a situated learning context and a rationale for learning science in an active, inquiry-based method, and worked in small collaborative…

First-Year University Science and Engineering Students' Understanding of Plagiarism

ERIC Educational Resources Information Center

Yeo, Shelley

2007-01-01

This paper is a case study of first-year science and engineering students' understandings of plagiarism. Students were surveyed for their views on scenarios illustrating instances of plagiarism in the context of the academic work and assessment of science and engineering students. The aim was to explore their understandings of plagiarism and their…

78 FR 9071 - Comment Request: National Science Foundation Proposal/Award Information-Grant Proposal Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

... research potential; Science and engineering education programs at all levels and in all the various fields... science and engineering and enhancing the potential for research and education to contribute to the Nation... NATIONAL SCIENCE FOUNDATION Comment Request: National Science Foundation Proposal/Award...

Minority engineering scholarships renewal, 2011.

DOT National Transportation Integrated Search

2012-08-01

Scholarships for Minority Students Studying Engineering and Science : Support will make scholarships available to minority students : interested in engineering and science and will increase significantly the number of minority students that Missouri ...

Minority engineering scholarships, 2012.

DOT National Transportation Integrated Search

2014-02-01

Scholarships for Minority Students Studying Engineering and Science: Support will make scholarships available to minority students : interested in engineering and science and will increase significantly the number of minority students that Missouri S...

Micro-separation toward systems biology.

PubMed

Liu, Bi-Feng; Xu, Bo; Zhang, Guisen; Du, Wei; Luo, Qingming

2006-02-17

Current biology is experiencing transformation in logic or philosophy that forces us to reevaluate the concept of cell, tissue or entire organism as a collection of individual components. Systems biology that aims at understanding biological system at the systems level is an emerging research area, which involves interdisciplinary collaborations of life sciences, computational and mathematical sciences, systems engineering, and analytical technology, etc. For analytical chemistry, developing innovative methods to meet the requirement of systems biology represents new challenges as also opportunities and responsibility. In this review, systems biology-oriented micro-separation technologies are introduced for comprehensive profiling of genome, proteome and metabolome, characterization of biomolecules interaction and single cell analysis such as capillary electrophoresis, ultra-thin layer gel electrophoresis, micro-column liquid chromatography, and their multidimensional combinations, parallel integrations, microfabricated formats, and nano technology involvement. Future challenges and directions are also suggested.

Systems biology solutions for biochemical production challenges.

PubMed

Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus; Herrgård, Markus J

2017-06-01

There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

78 FR 17234 - Advisory Committee for Mathematical Sciences and Physical Sciences #66; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

... Officer at the above address or the Web site at http://www.nsf.gov/mps/advisory.jsp . Purpose of Meeting... Opportunities in Science and Engineering, and the Advisory Committee for International Science and Engineering...

Silk fibroin in tissue engineering.

PubMed

Kasoju, Naresh; Bora, Utpal

2012-07-01

Tissue engineering (TE) is a multidisciplinary field that aims at the in vitro engineering of tissues and organs by integrating science and technology of cells, materials and biochemical factors. Mimicking the natural extracellular matrix is one of the critical and challenging technological barriers, for which scaffold engineering has become a prime focus of research within the field of TE. Amongst the variety of materials tested, silk fibroin (SF) is increasingly being recognized as a promising material for scaffold fabrication. Ease of processing, excellent biocompatibility, remarkable mechanical properties and tailorable degradability of SF has been explored for fabrication of various articles such as films, porous matrices, hydrogels, nonwoven mats, etc., and has been investigated for use in various TE applications, including bone, tendon, ligament, cartilage, skin, liver, trachea, nerve, cornea, eardrum, dental, bladder, etc. The current review extensively covers the progress made in the SF-based in vitro engineering and regeneration of various human tissues and identifies opportunities for further development of this field. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Biomaterials and scaffolds in reparative medicine

NASA Technical Reports Server (NTRS)

Chaikof, Elliot L.; Matthew, Howard; Kohn, Joachim; Mikos, Antonios G.; Prestwich, Glenn D.; Yip, Christopher M.; McIntire, L. V. (Principal Investigator)

2002-01-01

Most approaches currently pursued or contemplated within the framework of reparative medicine, including cell-based therapies, artificial organs, and engineered living tissues, are dependent on our ability to synthesize or otherwise generate novel materials, fabricate or assemble materials into appropriate 2-D and 3-D forms, and precisely tailor material-related physical and biological properties so as to achieve a desired clinical response. This paper summarizes the scientific and technological opportunities within the fields of biomaterials science and molecular engineering that will likely establish new enabling technologies for cellular and molecular therapies directed at the repair, replacement, or reconstruction of diseased or damaged organs and tissues.

Retraining the Modern Civil Engineer.

ERIC Educational Resources Information Center

Priscoli, Jerome Delli

1983-01-01

Discusses why modern engineering requires social science and the nature of planning. After these conceptional discussions, 12 practical tools which social science brings to engineering are reviewed. A tested approach to training engineers in these tools is then described. Tools include institutional analysis, policy profiling, and other impact…