Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment

PubMed Central

Vergidis, Pascalis; Clancy, Cornelius J.; Shields, Ryan K.; Park, Seo Young; Wildfeuer, Brett N.; Simmons, Richard L.; Nguyen, M. Hong

2016-01-01

Intra-abdominal candidiasis (IAC) is poorly understood compared to candidemia. We described the clinical characteristics, microbiology, treatment and outcomes of IAC, and identified risk factors for mortality. We performed a retrospective study of adults diagnosed with IAC at our center in 2012–2013. Risk factors for mortality were evaluated using multivariable logistic regression. We identified 163 patients with IAC, compared to 161 with candidemia. Types of IAC were intra-abdominal abscesses (55%), secondary peritonitis (33%), primary peritonitis (5%), infected pancreatic necrosis (5%), and cholecystitis/cholangitis (3%). Eighty-three percent and 66% of secondary peritonitis and abscesses, respectively, stemmed from gastrointestinal (GI) tract sources. C. albicans (56%) and C. glabrata (24%) were the most common species. Bacterial co-infections and candidemia occurred in 67% and 6% of patients, respectively. Seventy-two percent of patients underwent an early source control intervention (within 5 days) and 72% received early antifungal treatment. 100-day mortality was 28%, and highest with primary (88%) or secondary (40%) peritonitis. Younger age, abscesses and early source control were independent predictors of survival. Younger age, abscesses and early antifungal treatment were independently associated with survival for IAC stemming from GI tract sources. Infectious diseases (ID) consultations were obtained in only 48% of patients. Consulted patients were significantly more likely to receive antifungal treatment. IAC is a common disease associated with heterogeneous manifestations, which result in poor outcomes. All patients should undergo source control interventions and receive antifungal treatment promptly. It is important for the ID community to become more engaged in treating IAC. PMID:27123857

Ophthalmic Vascular Events after Primary Unilateral Intra-arterial Chemotherapy for Retinoblastoma in Early and Recent Eras.

PubMed

Dalvin, Lauren A; Ancona-Lezama, David; Lucio-Alvarez, J Antonio; Masoomian, Babak; Jabbour, Pascal; Shields, Carol L

2018-06-16

To assess risk factors for ophthalmic vascular events after intra-arterial chemotherapy (IAC) for retinoblastoma. Retrospective cohort study. Patients who received unilateral IAC as primary treatment for retinoblastoma from January 1, 2009, to November 30, 2017, at a single center. Records were reviewed for patient demographics, tumor features, IAC parameters, and treatment-related vascular events in the early IAC era (2009-2011) compared with the recent era (2012-2017) using the t test and Fisher exact test. Change in event rates over time was assessed using Poisson regression analysis, with Spearman's rho used to test correlation. Rate of IAC-induced ophthalmic vascular events. There were 243 chemotherapy infusions in 76 eyes of 76 patients, divided into early (22 eyes, 57 infusions) and recent (54 eyes, 186 infusions) eras. Intra-arterial chemotherapy consisted of melphalan (243 infusions), topotecan (124 infusions), and carboplatin (9 infusions). A comparison (early vs. recent era) revealed fewer mean number of infusions (2.6 vs. 3.4, P = 0.02) with similar mean patient age and presenting tumor features. Event rates decreased over time (P < 0.01), with fewer ophthalmic vascular events (early era vs. recent era) in the recent era (59% vs. 9% per eye, 23% vs. 3% per infusion, P < 0.01), including peripheral retinal nonperfusion (5% vs. 2% per eye, P = 0.50), vitreous hemorrhage (9% vs. 2%, P = 0.20), subretinal hemorrhage (0% vs. 2%, P = 0.99), branch retinal vein occlusion (5% vs. 0%, P = 0.29), choroidal ischemia (14% vs. 4%, P = 0.14), and ophthalmic artery spasm/occlusion (27% vs. 0%, P < 0.01). Events did not correlate to patient age (P = 0.75), tumor diameter (P = 0.32), tumor thickness (P = 0.59), or cumulative dosage of melphalan (P = 0.13) or topotecan (P = 0.59). There were no IAC-induced vascular events in 72 infusions of 21 consecutively treated eyes in 2016 to 2017. Ophthalmic vascular events after IAC have decreased from the early era (2009-2011) through the current era (2012-2017) at this center. Experience performing this highly specialized procedure could be an important factor predicting IAC-related vascular events. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Accreditation Status and Geographic Location of Outpatient Echocardiographic Testing Facilities Among Medicare Beneficiaries: The VALUE-ECHO Study.

PubMed

Brown, Scott C; Wang, Kefeng; Dong, Chuanhui; Yi, Li; Marinovic Gutierrez, Carolina; Di Tullio, Marco R; Farrell, Mary Beth; Burgess, Pamela; Gornik, Heather L; Hamburg, Naomi M; Needleman, Laurence; Orsinelli, David; Robison, Susana; Rundek, Tatjana

2018-02-01

Accreditation of echocardiographic testing facilities by the Intersocietal Accreditation Commission (IAC) is supported by the American College of Cardiology and American Society of Echocardiography. However, limited information exists on the accreditation status and geographic distribution of echocardiographic facilities in the United States. Our study aimed to identify (1) the proportion of outpatient echocardiography facilities used by Medicare beneficiaries that are IAC accredited, (2) their geographic distribution, and (3) variations in procedure type and volume by accreditation status. As part of the VALUE-ECHO (Value of Accreditation, Location, and Utilization Evaluation-Echocardiography) study, we examined the proportion of IAC-accredited echocardiographic facilities performing outpatient echocardiography in the 2013 Centers for Medicare and Medicaid Services outpatient limited data set (100% sample) and their geographic distribution using geocoding in ArcGIS (ESRI, Redlands, CA). Among 4573 outpatient facilities billing Medicare for echocardiographic testing in 2013, 99.6% (n = 4554) were IAC accredited (99.7% in the 50 US states and 86.2% in Puerto Rico). The proportion IAC-accredited echocardiographic facilities varied by region, with 98.7%, 99.9%, 99.9%, 99.5%, and 86.2% of facilities accredited in the Northeast, South, Midwest, West, and Puerto Rico, respectively (P < .01, Fisher exact test). Of all echocardiographic outpatient procedures conducted (n = 1,890,156), 99.8% (n = 1,885,382) were performed in IAC-accredited echocardiographic facilities. Most procedures (90.9%) were transthoracic echocardiograms, of which 99.7% were conducted in IAC-accredited echocardiographic facilities. Almost all outpatient echocardiographic facilities billed by Medicare are IAC accredited. This accreditation rate is substantially higher than previously reported for US outpatient vascular testing facilities (13% IAC accredited). The uniformity of imaging and interpretation protocols from a single accrediting body is important to facilitate optimal cardiovascular care. © 2017 by the American Institute of Ultrasound in Medicine.

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

Poleward transport variability in the Northern Hemisphere during final stratospheric warmings simulated by CESM(WACCM)

NASA Astrophysics Data System (ADS)

Thiéblemont, Rémi; Matthes, Katja; Orsolini, Yvan J.; Hauchecorne, Alain; Huret, Nathalie

2016-09-01

Observational studies of Arctic stratospheric final warmings have shown that tropical/subtropical air masses can be advected to high latitudes and remain confined within a long-lived "frozen-in" anticyclone (FrIAC) for several months. It was suggested that the frequency of FrIACs may have increased since 2000 and that their interannual variability may be modulated by (i) the occurrence of major stratospheric warmings (mSSWs) in the preceding winter and (ii) the phase of the quasi-biennial oscillation (QBO). In this study, we tested these observational-based hypotheses for the first time using a chemistry climate model. Three 145 year sensitivity experiments were performed with the National Center of Atmospheric Research's Community Earth System Model (CESM): one control experiment including only natural variability, one with an extreme greenhouse gas emission scenario, and one without the QBO in the tropical stratosphere. In comparison with reanalysis, the model simulates a realistic frequency and characteristics of FrIACs, which occur under an abrupt and early winter-to-summer stratospheric circulation transition, driven by enhanced planetary wave activity. Furthermore, the model results support the suggestion that the development of FrIACs is favored by an easterly QBO in the middle stratosphere and by the absence of mSSWs during the preceding winter. The lower stratospheric persistence of background dynamical state anomalies induced by deep mSSWs leads to less favorable conditions for planetary waves to enter the high-latitude stratosphere in April, which in turn decreases the probability of FrIAC development. Our model results do not suggest that climate change conditions (RCP8.5 scenario) influence FrIAC occurrences.

Poleward Transport Variability in the Northern Hemisphere during Final Stratospheric Warmings simulated by CESM(WACCM)

NASA Astrophysics Data System (ADS)

Thiéblemont, Rémi; Matthes, Katja; Orsolini, Yvan; Hauchecorne, Alain; Huret, Nathalie

2017-04-01

Observational studies of Arctic stratospheric final warmings have shown that tropical/subtropical air masses can be advected to high latitudes and remain confined within a long-lived "frozen-in" anticyclone (FrIAC) for several months. It was suggested that the frequency of FrIACs may have increased since 2000 and that their interannual variability may be modulated by (i) the occurrence of major stratospheric warmings (mSSWs) in the preceding winter and (ii) the phase of the Quasi-Biennial Oscillation (QBO). In this study, we tested these observational-based hypotheses for the first time using a chemistry-climate model. Three 145-year sensitivity experiments were performed with the National Center of Atmospheric Research's Community Earth System Model (CESM): one control experiment including only natural variability, one with an extreme greenhouse gas emission scenario, and one without the QBO in the tropical stratosphere. In comparison with reanalysis, the model simulates a realistic frequency and characteristics of FrIACs, which occur under an abrupt and early winter-to-summer stratospheric circulation transition, driven by enhanced planetary wave activity. Furthermore, the model results support the suggestion that the development of FrIACs is favored by an easterly QBO in the middle stratosphere and by the absence of mSSWs during the preceding winter. The lower stratospheric persistence of background dynamical state anomalies induced by deep mSSWs leads to less favorable conditions for planetary waves to enter the high-latitude stratosphere in April, which in turn decreases the probability of FrIAC development. Our model results do not suggest that climate change conditions (RCP8.5 scenario) influence FrIAC occurrences.

The Marketing of Information Analysis Center Products and Services.

ERIC Educational Resources Information Center

Veazie, Walter H., Jr.; Connolly, Thomas F.

Information analysis centers (IACs) represent a valuable national resource which has not been fully utilized, often because their products and services are not widely known. Recent Government economy measures demand consideration of increased marketability of these products and services and the institution of service charges as a possible source…

Metals and Ceramics Information Center.

DTIC Science & Technology

1981-07-01

Systems RESOURCE MANAGEMENT AND ECONOMIC ANALYSIS a Ordnance Technology a Space Systems and Applications a Biomass Resources 6 Business Planning • Economics ...r 19 KEY WORDS (Cwintince on reverse side 4 neressery and identify by block numnber) Technical Information Center Composites DoD Information Analysis ...The Metals and Ceramics Information Center (MCIC) is one of the technical Information Analysis Centers (IAC’s) chartered and sponsored by the

Leakage of Microbial Endotoxin through the Implant-Abutment Interface in Oral Implants: An In Vitro Study.

PubMed

Garrana, Rhoodie; Mohangi, Govindrau; Malo, Paulo; Nobre, Miguel

2016-01-01

Background . Endotoxin initiates osteoclastic activity resulting in bone loss. Endotoxin leakage through implant abutment connections negatively influences peri-implant bone levels. Objectives . (i) To determine if endotoxin can traverse different implant-abutment connection (IAC) designs; (ii) to quantify the amount of endotoxins traversing the IAC; (iii) to compare the in vitro comportments of different IACs. Materials and Methods . Twenty-seven IACs were inoculated with E. coli endotoxin. Six of the twenty-seven IACs were external connections from one system (Southern Implants) and the remaining twenty-one IACs were made up of seven internal IAC types from four different implant companies (Straumann, Ankylos, and Neodent, Southern Implants). Results . Of the 27 IACs tested, all 6 external IACs leaked measurable amounts of endotoxin. Of the remaining 21 internal IACs, 9 IACs did not show measurable leakage whilst the remaining 12 IACs leaked varying amounts. The mean log endotoxin level was significantly higher for the external compared to internal types ( p = 0.015). Conclusion . Within the parameters of this study, we can conclude that endotoxin leakage is dependent on the design of the IAC. Straumann Synocta, Straumann Cross-fit, and Ankylos displayed the best performances of all IACs tested with undetectable leakage after 7 days. Each of these IACs incorporated a morse-like component in their design. Speculation still exists over the impact of IAC endotoxin leakage on peri-implant tissues in vivo; hence, further investigations are required to further explore this.

30 CFR 914.15 - Approval of Indiana regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., -118; 12-5-6, -34, -35, -36, -38, -40; 12-5-73, -100, -100.5, -101, -103. February 7, 1985 May 13, 1985... 310 IAC 12-0.5-78.7, -91.5, -109; 12-3-30, -32, -33, -34, -41, -47, -49, -55, -55.1, -68, -70, -71... reclamation fees had been paid. December 9, 1982 March 4, 1983 310 IAC 12-2-7, -9; 12-3-1, -12(c)(2), -21(b)(4...

30 CFR 914.15 - Approval of Indiana regulatory program amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., -118; 12-5-6, -34, -35, -36, -38, -40; 12-5-73, -100, -100.5, -101, -103. February 7, 1985 May 13, 1985... 310 IAC 12-0.5-78.7, -91.5, -109; 12-3-30, -32, -33, -34, -41, -47, -49, -55, -55.1, -68, -70, -71... reclamation fees had been paid. December 9, 1982 March 4, 1983 310 IAC 12-2-7, -9; 12-3-1, -12(c)(2), -21(b)(4...

30 CFR 914.15 - Approval of Indiana regulatory program amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., -118; 12-5-6, -34, -35, -36, -38, -40; 12-5-73, -100, -100.5, -101, -103. February 7, 1985 May 13, 1985... 310 IAC 12-0.5-78.7, -91.5, -109; 12-3-30, -32, -33, -34, -41, -47, -49, -55, -55.1, -68, -70, -71... reclamation fees had been paid. December 9, 1982 March 4, 1983 310 IAC 12-2-7, -9; 12-3-1, -12(c)(2), -21(b)(4...

30 CFR 914.15 - Approval of Indiana regulatory program amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., -118; 12-5-6, -34, -35, -36, -38, -40; 12-5-73, -100, -100.5, -101, -103. February 7, 1985 May 13, 1985... 310 IAC 12-0.5-78.7, -91.5, -109; 12-3-30, -32, -33, -34, -41, -47, -49, -55, -55.1, -68, -70, -71... reclamation fees had been paid. December 9, 1982 March 4, 1983 310 IAC 12-2-7, -9; 12-3-1, -12(c)(2), -21(b)(4...

30 CFR 914.15 - Approval of Indiana regulatory program amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., -118; 12-5-6, -34, -35, -36, -38, -40; 12-5-73, -100, -100.5, -101, -103. February 7, 1985 May 13, 1985... 310 IAC 12-0.5-78.7, -91.5, -109; 12-3-30, -32, -33, -34, -41, -47, -49, -55, -55.1, -68, -70, -71... reclamation fees had been paid. December 9, 1982 March 4, 1983 310 IAC 12-2-7, -9; 12-3-1, -12(c)(2), -21(b)(4...

Finite area combustor theoretical rocket performance

NASA Technical Reports Server (NTRS)

Gordon, Sanford; Mcbride, Bonnie J.

1988-01-01

Previous to this report, the computer program of NASA SP-273 and NASA TM-86885 was capable of calculating theoretical rocket performance based only on the assumption of an infinite area combustion chamber (IAC). An option was added to this program which now also permits the calculation of rocket performance based on the assumption of a finite area combustion chamber (FAC). In the FAC model, the combustion process in the cylindrical chamber is assumed to be adiabatic, but nonisentropic. This results in a stagnation pressure drop from the injector face to the end of the chamber and a lower calculated performance for the FAC model than the IAC model.

Telemedicine information analysis center.

PubMed

Zajtchuk, Joan T; Zajtchuk, Russ; Petrovic, Joseph J; Gutz, Ryan P; Walrath, Benjamin D

2004-01-01

Congress mandated a pilot project to demonstrate the feasibility of establishing a Department of Defense (DoD) telemedicine information analysis center (TIAC). The project developed a medical information support system to show the core capabilities of a TIAC. The productivity and effectiveness of telemedicine researchers and clinical practitioners can be enhanced by the existence of an information analysis center (IACs) devoted to the collection, analysis, synthesis, and dissemination of worldwide scientific and technical information related to the field of telemedicine. The work conducted under the TIAC pilot project establishes the basic IAC functions and assesses the utility of the TIAC to the military medical departments. The pilot project capabilities are Web-based and include: (1) applying the science of classification (taxonomy) to telemedicine to identify key words; (2) creating a relational database of this taxonomy to a bibliographic database using these key words; (3) developing and disseminating information via a public TIAC Web site; (4) performing a specific baseline technical area task for the U.S. Army Medical Command; and (5) providing analyses by subject matter experts.

Annual Report of the Metals and Ceramics Information Center, 1 May 1979-30 April 1980.

DTIC Science & Technology

1980-07-01

MANAGEMENT AND ECONOMIC ANALYSIS DEPT. * Computer and Information SyslemsiD. C Operations 1 Battelle Technical Inputs to Planning * Computer Systems 0...Biomass Resources * Education 0 Business Planning * Information Systems * Economics , Planning and Policy Analysis * Statistical and Mathematical Modelrng...Metals and Ceramics Information Center (MCIC) is one of several technical information analysis centers (IAC’s) chartered and sponsored by the

MASTER OT J015539.85+485955.6 was detected during Fermi alert inspection 3.5h after the trigger time

NASA Astrophysics Data System (ADS)

Rebolo, R.; Lipunov, V.; Gorbovskoy, E.; Serra, M.; Lodieu, N.; Israelian, G.; Suarez-Andres, L.; Shumkov, V.; Tyurina, N.; Kornilov, V.; Balanutsa, P.; Kuznetsov, A.; Vlasenko, D.; Gorbunov, I.; Vladimirov, V.; Popova, E.; Buckley, D.; Potter, S.; Kniazev, A.; Kotze, M.; Tlatov, A.; Parhomenko, A. V.; Dormidontov, D.; Senik, V.; Gress, O.; Ivanov, K.; Budnev, N. M.; Yurkov, V.; Sergienko, Yu.; Gabovich, A.; Sinyakov, E.; Krushinski, V.; Zalozhnih, I.; Shurpakov, S.

2015-11-01

MASTER-IAC, MASTER-Kislovodsk and MASTER-SAAO was pointed to the FERMI GBM GRB151107B (Stanbro, Meegan, GCN #18570 ) at 2015-11-07 20:25:52(/59s/58s) UT (R.Rebolo et al., GCN #18576 ). There were the prompt pointing observations because duration of the GRB was ~140s . After 5 minutes of the alert observations of the error-box center, MASTER telescopes in IAC and Kislovodsk started the inspect survey inside large Fermi error box (ra=00 42 28 dec=+48 48 58 r=4.533300) obtained by GCN socket.

Accreditation status and geographic location of outpatient vascular testing facilities among Medicare beneficiaries: the VALUE (Vascular Accreditation, Location & Utilization Evaluation) study.

PubMed

Rundek, Tatjana; Brown, Scott C; Wang, Kefeng; Dong, Chuanhui; Farrell, Mary Beth; Heller, Gary V; Gornik, Heather L; Hutchisson, Marge; Needleman, Laurence; Benenati, James F; Jaff, Michael R; Meier, George H; Perese, Susana; Bendick, Phillip; Hamburg, Naomi M; Lohr, Joann M; LaPerna, Lucy; Leers, Steven A; Lilly, Michael P; Tegeler, Charles; Alexandrov, Andrei V; Katanick, Sandra L

2014-10-01

There is limited information on the accreditation status and geographic distribution of vascular testing facilities in the US. The Centers for Medicare & Medicaid Services (CMS) provide reimbursement to facilities regardless of accreditation status. The aims were to: (1) identify the proportion of Intersocietal Accreditation Commission (IAC) accredited vascular testing facilities in a 5% random national sample of Medicare beneficiaries receiving outpatient vascular testing services; (2) describe the geographic distribution of these facilities. The VALUE (Vascular Accreditation, Location & Utilization Evaluation) Study examines the proportion of IAC accredited facilities providing vascular testing procedures nationally, and the geographic distribution and utilization of these facilities. The data set containing all facilities that billed Medicare for outpatient vascular testing services in 2011 (5% CMS Outpatient Limited Data Set (LDS) file) was examined, and locations of outpatient vascular testing facilities were obtained from the 2011 CMS/Medicare Provider of Services (POS) file. Of 13,462 total vascular testing facilities billing Medicare for vascular testing procedures in a 5% random Outpatient LDS for the US in 2011, 13% (n=1730) of facilities were IAC accredited. The percentage of IAC accredited vascular testing facilities in the LDS file varied significantly by US region, p<0.0001: 26%, 12%, 11%, and 7% for the Northeast, South, Midwest, and Western regions, respectively. Findings suggest that the proportion of outpatient vascular testing facilities that are IAC accredited is low and varies by region. Increasing the number of accredited vascular testing facilities to improve test quality is a hypothesis that should be tested in future research. © The Author(s) 2014.

Endoscopically Assisted Drilling, Exposure of the Fundus through a Presigmoid Retrolabyrinthine Approach: A Cadaveric Feasibility Study.

PubMed

Muelleman, Thomas; Shew, Matthew; Alvi, Sameer; Shah, Kushal; Staecker, Hinrich; Chamoun, Roukouz; Lin, James

2018-01-01

The presigmoid retrolabyrinthine approach to the cerebellopontine angle is traditionally described to not provide access to the internal auditory canal (IAC). We aimed to evaluate the extent of the IAC that could be exposed with endoscopically assisted drilling and to measure the percentage of the IAC that could be visualized with the microscope and various endoscopes after drilling had been completed. Presigmoid retrolabyrinthine approaches were performed bilaterally on 4 fresh cadaveric heads. We performed endoscopically assisted drilling to expose the fundus of the IAC, which resulted in exposure of the entire IAC in 8 of 8 temporal bone specimens. The microscope afforded a mean view of 83% (n = 8) of the IAC. The 0°, 30°, 45°, and 70° endoscope each afforded a view of 100% of the IAC in 8 of 8 temporal bone specimens. In conclusion, endoscopic drilling of the IAC of can provide an extradural means of exposing the entire length of the IAC while preserving the labyrinth.

A randomized controlled trial of treatments for co-occurring substance use disorders and post-traumatic stress disorder.

PubMed

McGovern, Mark P; Lambert-Harris, Chantal; Xie, Haiyi; Meier, Andrea; McLeman, Bethany; Saunders, Elizabeth

2015-07-01

Post-traumatic stress disorder (PTSD) is common among people with substance use disorders, and the comorbidity is associated with negative outcomes. We report on a randomized controlled trial comparing the effect of integrated cognitive-behavioral therapy (ICBT) plus standard care, individual addiction counseling plus standard care and standard care alone on substance use and PTSD symptoms. Three-group, multi-site randomized controlled trial. Seven addiction treatment programs in Vermont and New Hampshire, USA. Recruitment took place between December 2010 and January 2013. In this single-blind study, 221 participants were randomized to one of three conditions: ICBT plus standard care (SC) (n = 73), individual addiction counseling (IAC) plus SC (n = 75) or SC only (n = 73). One hundred and seventy-two patients were assessed at 6-month follow-up (58 ICBT; 61 IAC; 53 SC). Intervention and comparators: ICBT is a manual-guided therapy focused on PTSD and substance use symptom reduction with three main components: patient education, mindful relaxation and flexible thinking. IAC is a manual-guided therapy focused exclusively on substance use and recovery with modules organized in a stage-based approach: treatment initiation, early abstinence, maintaining abstinence and recovery. SC are intensive out-patient program services that include 9-12 hours of face-to-face contact per week over 2-4 days of group and individual therapies plus medication management. Primary outcomes were PTSD severity and substance use severity at 6 months. Secondary outcomes were therapy retention. PTSD symptoms reduced in all conditions with no difference between them. In analyses of covariance, ICBT produced more favorable outcomes on toxicology than IAC or SC [comparison with IAC, parameter estimate: 1.10; confidence interval (CI) = 0.17-2.04; comparison with SC, parameter estimate: 1.13; CI = 0.18-2.08] and had a greater reduction in reported drug use than SC (parameter estimate: -9.92; CI = -18.14 to -1.70). ICBT patients had better therapy continuation versus IAC (P<0.001). There were no unexpected or study-related adverse events. Integrated cognitive behavioral therapy may improve drug-related outcomes in post-traumatic stress disorder sufferers with substance use disorder more than drug-focused counseling, but probably not by reducing post-traumatic stress disorder symptoms to a greater extent. © 2015 Society for the Study of Addiction.

IAC-POP: FINDING THE STAR FORMATION HISTORY OF RESOLVED GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aparicio, Antonio; Hidalgo, Sebastian L.

2009-08-15

IAC-pop is a code designed to solve the star formation history (SFH) of a complex stellar population system, like a galaxy, from the analysis of the color-magnitude diagram (CMD). It uses a genetic algorithm to minimize a {chi}{sup 2} merit function comparing the star distributions in the observed CMD and the CMD of a synthetic stellar population. A parameterization of the CMDs is used, which is the main input of the code. In fact, the code can be applied to any problem in which a similar parameterization of an experimental set of data and models can be made. The method'smore » internal consistency and robustness against several error sources, including observational effects, data sampling, and stellar evolution library differences, are tested. It is found that the best stability of the solution and the best way to estimate errors are obtained by several runs of IAC-pop with varying the input data parameterization. The routine MinnIAC is used to control this process. IAC-pop is offered for free use and can be downloaded from the site http://iac-star.iac.es/iac-pop. The routine MinnIAC is also offered under request, but support cannot be provided for its use. The only requirement for the use of IAC-pop and MinnIAC is referencing this paper and crediting as indicated in the site.« less

76 FR 40649 - Indiana Regulatory Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... at 312 IAC 25-6-30 Surface mining; explosives; general requirements. The full text of the program... DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement 30 CFR Part 914... Mining Reclamation and Enforcement, Interior. ACTION: Proposed rule; public comment period on proposed...

The integrated analysis capability (IAC Level 2.0)

NASA Technical Reports Server (NTRS)

Frisch, Harold P.; Vos, Robert G.

1988-01-01

The critical data management issues involved in the development of the integral analysis capability (IAC), Level 2, to support the design analysis and performance evaluation of large space structures, are examined. In particular, attention is given to the advantages and disadvantages of the formalized data base; merging of the matrix and relational data concepts; data types, query operators, and data handling; sequential versus direct-access files; local versus global data access; programming languages and host machines; and data flow techniques. The discussion also covers system architecture, recent system level enhancements, executive/user interface capabilities, and technology applications.

Data and Analysis Center for Software: An IAC in Transition.

DTIC Science & Technology

1983-06-01

reviewed and is approved for publication. * APPROVEDt Proj ect Engineer . JOHN J. MARCINIAK, Colonel, USAF Chief, Command and Control Division . FOR THE CO...SUPPLEMENTARY NOTES RADC Project Engineer : John Palaimo (COEE) It. KEY WORDS (Conilnuo n rever*e aide if necessary and identify by block numober...Software Engineering Software Technology Information Analysis Center Database Scientific and Technical Information 20. ABSTRACT (Continue on reverse side It

A Process and Outcomes Evaluation of the International AIDS Conference: Who Attends? Who Benefits Most?

PubMed Central

Lalonde, Bernadette; Wolvaardt, Jacqueline E.; Webb, Elize M; Tournas-Hardt, Amy

2007-01-01

The objective of the study was to conduct a process and outcomes evaluation of the International AIDS Conference (IAC). Reaction evaluation data are presented from a delegate survey distributed at the 2004 IAC held in Thailand. Input and output data from the Thailand IAC are compared to data from previous IACs to ascertain attendance and reaction trends, which delegates benefit most, and host country effects. Outcomes effectiveness data were collected via a survey and intercept interviews. Data suggest that the host country may significantly affect the number and quality of basic science IAC presentations, who attends, and who benefits most. Intended and executed HIV work-related behavior change was assessed under 9 classifications. Delegates who attended 1 previous IAC were more likely to report behavior changes than attendees who attended more than 1 previous IAC. The conference needs to be continually evaluated to elicit the required data to plan effective future IACs. PMID:17435615

IAC user manual

NASA Technical Reports Server (NTRS)

Vos, R. G.; Beste, D. L.; Gregg, J.

1984-01-01

The User Manual for the Integrated Analysis Capability (IAC) Level 1 system is presented. The IAC system currently supports the thermal, structures, controls and system dynamics technologies, and its development is influenced by the requirements for design/analysis of large space systems. The system has many features which make it applicable to general problems in engineering, and to management of data and software. Information includes basic IAC operation, executive commands, modules, solution paths, data organization and storage, IAC utilities, and module implementation.

Combined preoperative measurement of three inferior alveolar canal factors using computed tomography predicts the risk of inferior alveolar nerve injury during lower third molar extraction.

PubMed

Tachinami, H; Tomihara, K; Fujiwara, K; Nakamori, K; Noguchi, M

2017-11-01

A retrospective cohort study was performed to assess the clinical usefulness of combination assessment using computed tomography (CT) images in patients undergoing third molar extraction. This study included 85 patients (124 extraction sites). The relationship between cortication status, buccolingual position, and shape of the inferior alveolar canal (IAC) on CT images and the incidence of inferior alveolar nerve (IAN) injury after third molar extraction was evaluated. IAN injury was observed at eight of the 124 sites (6.5%), and in five of 19 sites (26.3%) in which cortication was absent+the IAC had a lingual position+the IAC had a dumbbell shape. Significant relationships were found between IAN injury and the three IAC factors (cortication status, IAC position, and IAC shape; P=0.0001). In patients with the three IAC factors, logistic regression analysis indicated a strong association between these factors and IAN injury (P=0.007). An absence of cortication, a lingually positioned IAC, and a dumbbell-shaped IAC are considered to indicate a high risk of IAN injury according to the logistic regression analysis (P=0.007). These results suggest that a combined assessment of these three IAC factors could be useful for the improved prediction of IAN injury. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Two methods for construction of internal amplification controls for the detection of Escherichia coli O157 by polymerase chain reaction.

PubMed

Abdulmawjood, A; Roth, S; Bülte, M

2002-10-01

For the detection of food born bacteria by polymerase chain reaction (PCR) in food products, an internal amplification control (IAC) is required in order to prevent false negative results that might be caused by PCR inhibitors. In the present study, two IACs were constructed using two different methods. These IACs were designed in a way that the same primer pair can be used to amplify the target DNA and coamplify the IAC. The first IAC with a size of approximately 200 bp was constructed by deleting a part of the amplicon of the original target DNA (500 bp) between the two primer sites to produce an IAC smaller than the target DNA. The second IAC with a size of approximately 600 bp was synthesized in a one step PCR reaction. The primers used in this reaction possessed 5' over-hanging ends, which were identical to the primers used in the diagnostic reaction, whereas their 3' ends were complementary to the (pUC19) predetermined DNA sequence of defined length and sequence. The concentration of IACs appeared to be critical. Too much IAC DNA template would out-compete the target DNA template, thus giving a false negative result. However the use of an optimal IAC concentration increased the reliability of the PCR assays and appeared to be useful for food diagnostics.

Reduction of Isoagglutinin in Intravenous Immunoglobulin (IVIG) Using Blood Group A- and B-Specific Immunoaffinity Chromatography: Industry-Scale Assessment.

PubMed

Gerber, Simon; Gaida, Annette; Spiegl, Nicole; Wymann, Sandra; Antunes, Adriano Marques; Menyawi, Ibrahim El; Zurbriggen, Brigitte; Hubsch, Alphonse; Imboden, Martin

2016-10-01

Hemolysis, a rare but potentially serious complication of intravenous immunoglobulin (IVIG) therapy, is associated with the presence of antibodies to blood groups A and B (isoagglutinins) in the IVIG product. An immunoaffinity chromatography (IAC) step in the production process could decrease isoagglutinin levels in IVIG. Our objectives were to compare isoagglutinin levels in a large number of IVIG (Privigen ® ) batches produced with or without IAC and to assess the feasibility of the production process with an IAC step on an industrial scale. The IAC column comprised a blend of anti-A and anti-B resins formed by coupling synthetic blood group antigens (A/B-trisaccharides) to a base bead matrix, and was introduced towards the end of the industrial-scale IVIG manufacturing process. Isoagglutinin levels in IVIG were determined by anti-A and anti-B hemagglutinin direct and indirect methods according to the European Pharmacopoeia (Ph. Eur.) and an isoagglutinin flow cytometry assay. IVIG product quality was assessed with respect to the retention of immunoglobulin G (IgG) subclasses, specific antibodies, and removal of IgM using standardized procedures. The IAC step reduced isoagglutinins in IVIG by two to three titer steps compared with lots produced without IAC. The median anti-A and anti-B titers with IAC were 1:8 and 1:4, respectively, when measured by the Ph. Eur. direct method, and 1:2 and <1, respectively, when measured by the Ph. Eur. indirect method. The isoagglutinin flow cytometry assay showed an 87-90 % reduction in isoagglutinins in post-IAC versus pre-IAC fractions. IAC alone reduced anti-A and anti-B of the IgMs isotype by 92.5-97.8 % and 95.4-99.2 %, respectively. Other product quality characteristics were similar with and without IAC. IAC is an effective method for reducing isoagglutinin levels in IVIG, and it is feasible on an industrial scale.

Sheila Hayter | NREL

Science.gov Websites

Hayter Photo of Sheila Hayter Sheila Hayter Group Manager - Strategy, Policy, & Implementation Group Sheila.Hayter@nrel.gov | 303-384-7519 Sheila has been with NREL for more than 25 years and is presently a group manager within the Integrated Application Center (IAC) leading a team of technical and

Pharmacokinetics of isochlorgenic acid C in rats by HPLC-MS: Absolute bioavailability and dose proportionality.

PubMed

Huang, Li Hua; Xiong, Xiao Hong; Zhong, Yun Ming; Cen, Mei Feng; Cheng, Xuan Ge; Wang, Gui Xiang; Zang, Lin Quan; Wang, Su Jun

2016-06-05

Isochlorgenic acid C (IAC), one of the bioactive compounds of Lonicera japonica, exhibited diverse pharmacological effects. However, its pharmacokinetic properties and bioavailability remained unresolved. To determine the absolute bioavailability in rats and the dose proportionality on the pharmacokinetics of single oral dose of IAC. A validated HPLC-MS method was developed for the determination of IAC in rat plasma. Plasma concentration versus time data were generated following oral and intravenous dosing. The pharmacokinetic analysis was performed using DAS 3.0 software analysis. Absolute bioavailability in rats was determined by comparing pharmacokinetic data after administration of single oral (5, 10 and 25mgkg(-1)) and intravenous (5mgkg(-1)) doses of IAC. The dose proportionality of AUC(0-∞) and Cmax were analyzed by linear regression. Experimental data showed that absolute oral bioavailability of IAC in rats across the doses ranged between 14.4% and 16.9%. The regression analysis of AUC(0-∞) and Cmax at the three doses (5, 10 and 25mgkg(-1)) indicated that the equations were y=35.23x+117.20 (r=0.998) and y=121.03x+255.74 (r=0.995), respectively. A new HPLC-MS method was developed to determine the bioavailability and the dose proportionality of IAC. Bioavailability of IAC in rats was poor and both Cmax and AUC(0-∞) of IAC had a positive correlation with dose. Evaluation of the pharmacokinetics of IAC will be useful in assessing concentration-effect relationships for the potential therapeutic applications of IAC. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Presence of intracranial artery calcification is associated with mortality and vascular events in patients with ischemic stroke after hospital discharge: a cohort study.

PubMed

Bugnicourt, Jean-Marc; Leclercq, Claire; Chillon, Jean-Marc; Diouf, Momar; Deramond, Hervé; Canaple, Sandrine; Lamy, Chantal; Massy, Ziad A; Godefroy, Olivier

2011-12-01

Although intracranial artery calcification (IAC) has been reported to be a risk factor for ischemic stroke, the prognostic implications of IAC in stroke outcome are unknown. The purpose of this study was to determine the association between IAC and risk of vascular events and death in patients with stroke after hospital discharge. All patients with ischemic stroke over a 1-year period were included (n=302). IAC, assessed by multidetector CT, was defined as hyperdense foci (peak density>130 Hounsfield units) and assessed in the 7 major cerebral arteries. The IAC scores ranged from 0 (no calcification) to 7. Follow-up information on major clinical events (including fatal or nonfatal ischemic stroke, cardiac and peripheral artery events, and all-cause death) was obtained by means of a structured phone interview. IAC was present in 260 patients (83%). With a mean follow-up of 773±223 days, 88 major clinical events occurred in 67 patients (22%): 45 new ischemic vascular events (ischemic stroke: n=22; cardiac event: n=15; peripheral artery event: n=8) and 43 deaths from any cause. Patients with the highest IAC scores had significantly higher rates of death and vascular events than those with the lowest IAC scores (log rank test, P=0.029). In the Cox proportional hazards regression model, the IAC score was significantly associated with major clinical events (hazard ratio, 1.34; 95% CI, 1.11-1.61; P=0.002). In patients with ischemic stroke, IAC detection may constitute a simple marker of a high risk of future major clinical events.

Role of IAC in large space systems thermal analysis

NASA Technical Reports Server (NTRS)

Jones, G. K.; Skladany, J. T.; Young, J. P.

1982-01-01

Computer analysis programs to evaluate critical coupling effects that can significantly influence spacecraft system performance are described. These coupling effects arise from the varied parameters of the spacecraft systems, environments, and forcing functions associated with disciplines such as thermal, structures, and controls. Adverse effects can be expected to significantly impact system design aspects such as structural integrity, controllability, and mission performance. One such needed design analysis capability is a software system that can integrate individual discipline computer codes into a highly user-oriented/interactive-graphics-based analysis capability. The integrated analysis capability (IAC) system can be viewed as: a core framework system which serves as an integrating base whereby users can readily add desired analysis modules and as a self-contained interdisciplinary system analysis capability having a specific set of fully integrated multidisciplinary analysis programs that deal with the coupling of thermal, structures, controls, antenna radiation performance, and instrument optical performance disciplines.

Identifying Energy Savings in Water and Wastewater Plants - Indiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Since 1976, Industrial Assessment Centers (IACs) administered by the U.S. Department of Energy have supported small and medium-sized American manufacturers to reduce their energy use and improve their productivity and competitiveness. DOE is now offering up to 50 assessments per year at no cost to industrial or municipal water and wastewater plants.

Identifying Energy Savings in Water and Wastewater Plants - Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-03-01

Since 1976, Industrial Assessment Centers (IACs) administered by the U.S. Department of Energy have supported small and medium-sized American manufacturers to reduce their energy use and improve their productivity and competitiveness. DOE is now offering up to 50 assessments per year at no cost to industrial or municipal water and wastewater plants.

77 FR 73480 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... Florence, AZ 85232. 85132. Yavapai Town of Camp Verde The Honorable Bob Town Clerk's http://www.r9map.org... Camp Main Street, Room 040131-102IAC.pdf. Verde, 473 South 102, Camp Verde, Main Street, AZ 86322. Suite 102, Camp Verde, AZ 86322. California: Orange City of Irvine (12- The Honorable 1 Civic Center...

Identifying Energy Savings in Water and Wastewater Plants - Wisconsin

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-03-01

Since 1976, Industrial Assessment Centers (IACs) administered by the U.S. Department of Energy have supported small and medium-sized American manufacturers to reduce their energy use and improve their productivity and competitiveness. DOE is now offering up to 50 assessments per year at no cost to industrial or municipal water and wastewater plants.

Identifying Energy Savings in Water and Wastewater Plants - Iowa

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-03-01

Since 1976, Industrial Assessment Centers (IACs) administered by the U.S. Department of Energy have supported small and medium-sized American manufacturers to reduce their energy use and improve their productivity and competitiveness. DOE is now offering up to 50 assessments per year at no cost to industrial or municipal water and wastewater plants.

Immunoaffinity chromatography: an introduction to applications and recent developments

PubMed Central

Moser, Annette C

2010-01-01

Immunoaffinity chromatography (IAC) combines the use of LC with the specific binding of antibodies or related agents. The resulting method can be used in assays for a particular target or for purification and concentration of analytes prior to further examination by another technique. This review discusses the history and principles of IAC and the various formats that can be used with this method. An overview is given of the general properties of antibodies and of antibody-production methods. The supports and immobilization methods used with antibodies in IAC and the selection of application and elution conditions for IAC are also discussed. Several applications of IAC are considered, including its use in purification, immunodepletion, direct sample analysis, chromatographic immunoassays and combined analysis methods. Recent developments include the use of IAC with CE or MS, ultrafast immunoextraction methods and the use of immunoaffinity columns in microanalytical systems. PMID:20640220

Feasibility Survey of Pilot Prevention and Health Intervention Strategies Management Information Analysis Center (PRHISM-IAC)

DTIC Science & Technology

1993-06-01

Health Last Name: Belk City: San Diego First Name: William F. Col State: CA Phone Number: (208)526-1596 Zip: 92182 Address: 2619 Balboa Dr. City: Idaho ...Lowell A. Col Last Name: Santana Address: 1365 Tammany Creek Road First Name: Frederick Dr. City: Lewiston Phone Number: 202-427-5365 State: ID Company

Analysis of electricity consumption: a study in the wood products industry

Treesearch

Henry Quesada-Pineda; Jan Wiedenbeck; Brian Bond

2016-01-01

This paper evaluates the effect of industry segment, year, and US region on electricity consumption per employee, per dollar sales, and per square foot of plant area for wood products industries. Data was extracted from the Industrial Assessment Center (IAC) database and imported into MS Excel. The extracted dataset was examined for outliers and abnormalities with...

Buildings News | Buildings | NREL

Science.gov Websites

contributions to NREL and the larger scientific community. March 30, 2018 Q&A with Sheila Hayter: Laying the Applications Center (IAC), leading a team of experts who support international, federal, state, and local Release: NREL Research Determines Integration of Plug-in Electric Vehicles Should Play a Big Role in

A Study of Experience Credit for Professional Engineering Licensure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, M.A.

2003-08-11

Oak Ridge National Laboratory performed a study of experience credit for professional engineering licensure for the Department of Energy's Industrial Assessment Center (IAC) Program. One of the study's goals was to determine how state licensure boards grant experience credit for engineering licensure, particularly in regards to IAC experience and experience prior to graduation. Another goal involved passing IAC information to state licensure boards to allow the boards to become familiar with the program and determine if they would grant credit to IAC graduates. The National Council of Examiners for Engineers and Surveyors (NCEES) has adopted a document, the ''Model Law''.more » This document empowers states to create state engineering boards and oversee engineering licensure. The board can also interpret and adopt rules and regulations. The Model Law also gives a general ''process'' for engineering licensure, the ''Model Law Engineer''. The Model Law Engineer requires that an applicant for professional licensure, or professional engineering (PE) licensure, obtain a combination of formal education and professional experience and successfully complete the fundamentals of engineering (FE) and PE exams. The Model Law states that a PE applicant must obtain four years of ''acceptable'' engineering experience after graduation to be allowed to sit for the PE exam. Although the Model Law defines ''acceptable experience,'' it is somewhat open to interpretation, and state boards decide whether applicants have accumulated the necessary amount of experience. The Model Law also allows applicants one year of credit for postgraduate degrees as well as experience credit for teaching courses in engineering. The Model Law grants states the power to adopt and amend the bylaws and rules of the Model Law licensure process. It allows state boards the freedom to modify the experience requirements for professional licensure. This power has created variety in experience requirements, and licensure requirements can differ from state to state. Before this study began, six questions were developed to help document how state boards grant experience credit. Many of the questions were formulated to determine how states deal with teaching experience, postgraduate credit, experience prior to graduation, PE and FE waivers, and the licensure process in general. Data were collected from engineering licensure boards for each of the fifty states and the District of Columbia. Telephone interviews were the primary method of data collection, while email correspondence was also used to a lesser degree. Prior to contacting each board, the researchers attempted to review each state's licensure web site. Based on the data collected, several trends and patterns were identified. For example, there is a general trend away from offering credit for experience prior to graduation. The issue becomes a problem when a PE from one state attempts to gain a license in another state by comity or endorsement. Tennessee and Kansas have recently stopped offering this credit and Mississippi cautions applicants that it could be difficult to obtain licensure in other states.« less

Analysis on clinical characteristics of intracranial Arachnoid Cysts in 488 pediatric cases

PubMed Central

Huang, Jian-Huang; Mei, Wen-Zhong; Chen, Yao; Chen, Jian-Wu; Lin, Zhi-Xiong

2015-01-01

To summarize the clinical characteristics of intracranial arachnoid cysts (IACs) in pediatric cases. A retrospective analysis was carried out on clinical characteristics of IACs in 488 pediatric cases who were treated at our hospital from January 2003 to September 2013. There were 342 males and 146 females (male-to-female ratio, 2.34:1), aged 5.61±3.25 years on average. 221 cases (45.29%) were diagnosed accidentally, 267 cases had clinical complaints (54.71%), among which relationships between clinical complaints and IACs were identified in 123 (46.07%). Simple IACs occurred in 364 cases (4.59%), and concurrent congenital abnormalities occurred in 124 cases (4.59%). In terms of location, 355 had IACs in middle cranial fossa (72.75%), 82 cases in posterior cranial fossa (16.80%), 20 cases in anterior cranial fossa (4.10%), 12 cases in dorsolateral surface (2.46%), 7 cases in suprasellar cistern (1.43%), 5 cases in cerebral ventricle (1.02%), 5 cases in quadrigeminal cistern (1.02%), and 2 cases in interhemispheric region (0.41%). There were 449 cases with single IAC (92.01%) and 39 cases with multiple IACs (7.99%). On MRI, the cysts produced tension in 127 cases (26.02%), but not in the remaining 361 cases (73.98%). Surgery was performed on 76 of 488 cases (15.57%), while conservative observation was accepted in 412 cases (84.43%). For the former, the symptoms and the cyst volume were improved to varying extent; for the latter, the follow-up lasting for 3-72 months (average 32.43±8.92 months) showed that the cyst volume remained stable in 407 cases (98.78%), enlarged with aggravated symptoms in 3 cases (0.73%), and shrank in 2 cases (0.49%). Clinical complaints of IACs varied in pediatric cases, and the relationships between clinical complaints and IACs were established only partially. Some pediatric cases were combined with other congenital abnormalities. The cyst volume largely remained stable during the disease course, and surgery was required for only a few IACs. PMID:26770437

Method for determination of aflatoxin M₁ in cheese and butter by HPLC using an immunoaffinity column.

PubMed

Sakuma, Hisako; Kamata, Yoichi; Sugita-Konishi, Yoshiko; Kawakami, Hiroshi

2011-01-01

A rapid, sensitive convenient method for determination of aflatoxin M₁ (AFM₁) in cheese and butter by HPLC was developed and validated. The method employs a safe extraction solution (mixture of acetonitrile, methanol and water) and an immunoaffinity column (IAC) for clean-up. Compared with the widely used method employing chloroform and a Florisil column, the IAC method has a short analytical time and there are no interference peaks. The limits of quantification (LOQ) of the IAC method were 0.12 and 0.14 µg/kg, while those of the Florisil column method were 0.47 and 0.23 µg/kg in cheese and buffer, respectively. The recovery and relative standard deviation (RSD) for cheese (spiked at 0.5 µg/kg) in the IAC method were 92% and 7%, respectively, while for the Florisil column method the corresponding values were 76% and 10%. The recovery and RSD for butter (spiked at 0.5 µg/kg) in the IAC method were 97% and 9%, and those in the Florisil method were 74% and 9%, respectively. In the IAC method, the values of in-house precision (n=2, day=5) of cheese and butter (spiked at 0.5 µg/kg) were 9% and 13%, respectively. The IAC method is superior to the Florisil column method in terms of safety, ease of handling, sensitivity and reliability. A survey of AFM₁ contamination in imported cheese and butter in Japan was conducted by the IAC method. AFM₁ was not detected in 60 samples of cheese and 30 samples of butter.

Transgenic elite indica rice plants expressing CryIAc delta-endotoxin of Bacillus thuringiensis are resistant against yellow stem borer (Scirpophaga incertulas).

PubMed

Nayak, P; Basu, D; Das, S; Basu, A; Ghosh, D; Ramakrishnan, N A; Ghosh, M; Sen, S K

1997-03-18

Generation of insect-resistant, transgenic crop plants by expression of the insecticidal crystal protein (ICP) gene of Bacillus thuringiensis (Bt) is a standard crop improvement approach. In such cases, adequate expression of the most appropriate ICP against the target insect pest of the crop species is desirable. It is also considered advantageous to generate Bt-transgenics with multiple toxin systems to control rapid development of pest resistance to the ICP. Larvae of yellow stem borer (YSB), Scirpophaga incertulas, a major lepidopteran insect pest of rice, cause massive losses of rice yield. Studies on insect feeding and on the binding properties of ICP to brush border membrane receptors in the midgut of YSB larvae revealed that cryIAb and cryIAc are two individually suitable candidate genes for developing YSB-resistant rice. Programs were undertaken to develop Bt-transgenic rice with these ICP genes independently in a single cultivar. A cryIAc gene was reconstructed and placed under control of the maize ubiquitin 1 promoter, along with the first intron of the maize ubiquitin 1 gene, and the nos terminator. The gene construct was delivered to embryogenic calli of IR64, an elite indica rice cultivar, using the particle bombardment method. Six highly expressive independent transgenic ICP lines were identified. Molecular analyses and insect-feeding assays of two such lines revealed that the transferred synthetic cryIAc gene was expressed stably in the T2 generation of these lines and that the transgenic rice plants were highly toxic to YSB larvae and lessened the damage caused by their feeding.

A Novel Real-Time PCR for Listeria monocytogenes That Monitors Analytical Performance via an Internal Amplification Control

PubMed Central

Rodríguez-Lázaro, David; Pla, Maria; Scortti, Mariela; Monzó, Héctor J.; Vázquez-Boland, José A.

2005-01-01

We describe a novel quantitative real-time (Q)-PCR assay for Listeria monocytogenes based on the coamplification of a target hly gene fragment and an internal amplification control (IAC). The IAC is a chimeric double-stranded DNA containing a fragment of the rapeseed BnACCg8 gene flanked by the hly-specific target sequences. This IAC is detected using a second TaqMan probe labeled with a different fluorophore, enabling the simultaneous monitoring of the hly and IAC signals. The hly-IAC assay had a specificity and sensitivity of 100%, as assessed using 49 L. monocytogenes isolates of different serotypes and 96 strains of nontarget bacteria, including 51 Listeria isolates. The detection and quantification limits were 8 and 30 genome equivalents, and the coefficients for PCR linearity (R2) and efficiency (E) were 0.997 and 0.80, respectively. We tested the performance of the hly-IAC Q-PCR assay using various broth media and food matrices. Fraser and half-Fraser media, raw pork, and raw or cold-smoked salmon were strongly PCR-inhibitory. This Q-PCR assay for L. monocytogenes, the first incorporating an IAC to be described for quantitative detection of a food-borne pathogen, is a simple and robust tool facilitating the identification of false negatives or underestimations of contamination loads due to PCR failure. PMID:16332910

The role of chest radiographs and tuberculin skin tests in tuberculosis screening of internationally adopted children.

PubMed

George, Sobenna A; Ko, Catherine A; Kirchner, H Lester; Starke, Jeffrey R; Dragga, Therese A; Mandalakas, Anna M

2011-05-01

Internationally adopted children (IAC) are a growing group of US immigrants who often come from countries with high tuberculosis (TB) burdens. There is limited evidence to support current TB screening guidelines in these high-risk children. Therefore, we have prospectively examined the clinical utility of tuberculin skin testing (TST) and subsequent chest radiograph screening for TB disease in recently immigrated, asymptomatic IAC. Within 6 months of immigration to the United States, we collected demographic information and assessed the nutritional status of 566 IAC who presented for routine postadoptive care. Children completed standardized clinical examination and TSTs. Chest radiographs were recommended for children with TST induration ≥ 5 mm. The association between TST induration and clinical outcome was assessed. The clinical utility of chest radiographs was evaluated. There was no difference in age, birth country, or nutritional status between IAC with TST induration of 0 to < 5 mm and those with 5 to < 10 mm; IAC with TST ≥ 10 mm were older, more chronically malnourished, and more likely to emigrate from Guatemala. Among children with TST ≥ 5 mm (35%), 4 IAC had chest radiographs which were initially interpreted to be abnormal and consistent with TB; ultimately none were diagnosed with TB. The 5-mm TST cut point did not capture IAC with risk factors for latent TB infection or progression to TB disease, suggesting that this is not a useful screening threshold. In contrast, a 10-mm cut point identified IAC at risk for TB infection and therefore should be a more useful screening threshold. We question the clinical utility of radiographic screening for pulmonary TB in asymptomatic children.

Characterization of a Prenyltransferase for Iso-A82775C Biosynthesis and Generation of New Congeners of Chloropestolides.

PubMed

Pan, Yuanyuan; Liu, Ling; Guan, Feifei; Li, Erwei; Jin, Jin; Li, Jinyang; Che, Yongsheng; Liu, Gang

2018-03-16

Chloropupukeananin and chloropestolides are novel metabolites of the plant endophyte Pestalotiopsis fici, showing antimicrobial, antitumor, and anti-HIV activities. Their highly complex and unique skeletons were generated from the coisolated pestheic acid (1) and iso-A82775C (10) based on our previous studies. Here, we identified the biosynthetic gene cluster iac of 10 and characterized an iacE encoded prenyltransferase. Deletion of iacE abolished iso-A82775C production, accumulated the prenyl group-lacking siccayne (2), and generated four new chloropestolides (3-6). Compounds 5 and 6 showed antibacterial effects against Staphylococcus aureus and Bacillus subtilis, and 5 was also cytotoxic to human tumor cell lines HeLa, MCF-7, and SW480. These results provided the first genetic and biochemical insights into the biosynthesis of natural prenylepoxycyclohexanes and demonstrated the feasibility for generation of diversified congeners by manipulating the biosynthetic genes of 10.

Improving memory after interruption: exploiting soft constraints and manipulating information access cost.

PubMed

Morgan, Phillip L; Patrick, John; Waldron, Samuel M; King, Sophia L; Patrick, Tanya

2009-12-01

Forgetting what one was doing prior to interruption is an everyday problem. The recent soft constraints hypothesis (Gray, Sims, Fu, & Schoelles, 2006) emphasizes the strategic adaptation of information processing strategy to the task environment. It predicts that increasing information access cost (IAC: the time, and physical and mental effort involved in accessing information) encourages a more memory-intensive strategy. Like interruptions, access costs are also intrinsic to most work environments, such as when opening documents and e-mails. Three experiments investigated whether increasing IAC during a simple copying task can be an effective method for reducing forgetting following interruption. IAC was designated Low (all information permanently visible), Medium (a mouse movement to uncover target information), or High (an additional few seconds to uncover such information). Experiment 1 found that recall improved across all three levels of IAC. Subsequent experiments found that High IAC facilitated resumption after interruption, particularly when interruption occurred on half of all trials (Experiment 2), and improved prospective memory following two different interrupting tasks, even when one involved the disruptive effect of using the same type of resource as the primary task (Experiment 3). The improvement of memory after interruption with increased IAC supports the prediction of the soft constraints hypothesis. The main disadvantage of a high access cost was a reduction in speed of task completion. The practicality of manipulating IAC as a design method for inducing a memory-intensive strategy to protect against forgetting is discussed. Copyright 2009 APA

Unconventional Three-Armed Luminogens Exhibiting Both Aggregation-Induced Emission and Thermally Activated Delayed Fluorescence Resulting in High-Performing Solution-Processed Organic Light-Emitting Diodes.

PubMed

Park, Seo Yeon; Choi, Suna; Park, Gi Eun; Kim, Hyung Jong; Lee, Chiho; Moon, Ji Su; Kim, Si Woo; Park, Sungnam; Kwon, Jang Hyuk; Cho, Min Ju; Choi, Dong Hoon

2018-05-02

In this work, three-armed luminogens IAcTr-out and IAcTr-in were synthesized and used as emitters bearing triazine and indenoacridine moieties in thermally activated delayed fluorescence organic light-emitting diodes (OLEDs). These molecules could form a uniform thin film via the solution process and also allowed the subsequent deposition of an electron transporting layer either by vacuum deposition or by an all-solution coating method. Intriguingly, the new luminogens displayed aggregation-induced emission (AIE), which is a unique photophysical phenomenon. As a nondoped emitting layer (EML), IAcTr-in showed external quantum efficiencies (EQEs) of 11.8% for the hybrid-solution processed OLED and 10.9% for the all-solution processed OLED with a low efficiency roll-off. This was evident by the higher photoluminescence quantum yield and higher rate constant of reverse intersystem crossing of IAcTr-in, as compared to IAcTr-out. These AIE luminogens were used as dopants and mixed with the well-known host material 1,3-bis( N-carbazolyl)benzene (mCP) to produce a high-efficiency OLED with a two-component EML. The maximum EQE of 17.5% was obtained when using EML with IAcTr-out doping (25 wt %) into mCP, and the OLED with EML bearing IAcTr-in and mCP showed a higher maximum EQE of 18.4% as in the case of the nondoped EML-based device.

IAC Library: Some Challenges

NASA Astrophysics Data System (ADS)

Gomez, M.

2010-10-01

Since its beginnings in 1985, the IAC Library has evolved from a traditional library where the physical place and collections were essential, to a hybrid library where users can often get what they need without going to the library. In this paper, we present how the various changes due to information technology advances that occurred in the 1990s, followed by a series of works carried out from 2004 to 2008 at IAC, as well as several internal and external events or decisions, have led the IAC Library to face three new challenges. First, as the library building has been enlarged and new spaces are now available for users and for shelving, we have to decide what we should we do with the new spaces. How we can make them attractive for users at a time when users often don't need to visit the library to access the information they need? Second, as IAC will implement a new integrated information system, we have an opportunity to define how the library system will participate within the IAC global information system, bringing to this great project our knowledge of information management, essential to improve the actual processes. Third, as the Ministry has created a working group on access to electronic resources, with participation by seven affiliated research institutions, we have, as a member of this group, to define how to deal with the Ministry and the other centres to set a library policy that will benefit the IAC Library.

Data model for the collaboration between land administration systems and agricultural land parcel identification systems.

PubMed

Inan, Halil Ibrahim; Sagris, Valentina; Devos, Wim; Milenov, Pavel; van Oosterom, Peter; Zevenbergen, Jaap

2010-12-01

The Common Agricultural Policy (CAP) of the European Union (EU) has dramatically changed after 1992, and from then on the CAP focused on the management of direct income subsidies instead of production-based subsidies. For this focus, Member States (MS) are expected to establish Integrated Administration and Control System (IACS), including a Land Parcel Identification System (LPIS) as the spatial part of IACS. Different MS have chosen different solutions for their LPIS. Currently, some MS based their IACS/LPIS on data from their Land Administration Systems (LAS), and many others use purpose built special systems for their IACS/LPIS. The issue with these different IACS/LPIS is that they do not have standardized structures; rather, each represents a unique design in each MS, both in the case of LAS based or special systems. In this study, we aim at designing a core data model for those IACS/LPIS based on LAS. For this purpose, we make use of the ongoing standardization initiatives for LAS (Land Administration Domain Model: LADM) and IACS/LPIS (LPIS Core Model: LCM). The data model we propose in this study implies the collaboration between LADM and LCM and includes some extensions. Some basic issues with the collaboration model are discussed within this study: registration of farmers, land use rights and farming limitations, geometry/topology, temporal data management etc. For further explanation of the model structure, sample instance level diagrams illustrating some typical situations are also included. Copyright © 2010 Elsevier Ltd. All rights reserved.

Development and Implementation of a Quality Improvement Process for Echocardiographic Laboratory Accreditation.

PubMed

Gilliland, Yvonne E; Lavie, Carl J; Ahmad, Homaa; Bernal, Jose A; Cash, Michael E; Dinshaw, Homeyar; Milani, Richard V; Shah, Sangeeta; Bienvenu, Lisa; White, Christopher J

2016-03-01

We describe our process for quality improvement (QI) for a 3-year accreditation cycle in echocardiography by the Intersocietal Accreditation Commission (IAC) for a large group practice. Echocardiographic laboratory accreditation by the IAC was introduced in 1996, which is not required but could impact reimbursement. To ensure high-quality patient care and community recognition as a facility committed to providing high-quality echocardiographic services, we applied for IAC accreditation in 2010. Currently, there is little published data regarding the IAC process to meet echocardiography standards. We describe our approach for developing a multicampus QI process for echocardiographic laboratory accreditation during the 3-year cycle of accreditation by the IAC. We developed a quarterly review assessing (1) the variability of the interpretations, (2) the quality of the examinations, (3) a correlation of echocardiographic studies with other imaging modalities, (4) the timely completion of reports, (5) procedure volume, (6) maintenance of Continuing Medical Education credits by faculty, and (7) meeting Appropriate Use Criteria. We developed and implemented a multicampus process for QI during the 3-year accreditation cycle by the IAC for Echocardiography. We documented both the process and the achievement of those metrics by the Echocardiography Laboratories at the Ochsner Medical Institutions. We found the QI process using IAC standards to be a continuous educational experience for our Echocardiography Laboratory physicians and staff. We offer our process as an example and guide for other echocardiography laboratories who wish to apply for such accreditation or reaccreditation. © 2016, Wiley Periodicals, Inc.

Adherence and competence in two manual-guided therapies for co-occurring substance use and posttraumatic stress disorders: clinician factors and patient outcomes.

PubMed

Meier, Andrea; McGovern, Mark P; Lambert-Harris, Chantal; McLeman, Bethany; Franklin, Anna; Saunders, Elizabeth C; Xie, Haiyi

2015-01-01

The challenges of implementing and sustaining evidence-based therapies into routine practice have been well-documented. This study examines the relationship among clinician factors, quality of therapy delivery, and patient outcomes. Within a randomized controlled trial, 121 patients with current co-occurring substance use and posttraumatic stress disorders were allocated to receive either manualized Integrated Cognitive Behavioral Therapy (ICBT) or Individual Addiction Counseling (IAC). Twenty-two clinicians from seven addiction treatment programs were trained and supervised to deliver both therapies. Clinician characteristics were assessed at baseline; clinician adherence and competence were assessed over the course of delivering both therapies; and patient outcomes were measured at baseline and 6-month follow-up. Although ICBT was delivered at acceptable levels, clinicians were significantly more adherent to IAC (p < 0.05). At session 1, clinical female gender (p < 0.05) and lower education level (p < 0.05) were predictive of increased clinician adherence and competence across both therapies. Adherence and competence at session 1 in either therapy were significantly predictive of positive patient outcomes. ICBT adherence (p < 0.05) and competence (p < 0.01) were predictive of PTSD symptom reduction, whereas IAC adherence (p < 0.01) and competence (p < 0.01) were associated with decreased drug problem severity. The differential impact of adherence and competence for both therapy types is consistent with their purported primary target: ICBT for PTSD and IAC for substance use. These findings also suggest the benefits of considering clinician factors when implementing manual-guided therapies. Future research should focus on diverse clinician samples, randomization of clinicians to therapy type, and prospective designs to evaluate models of supervision and quality monitoring.

Transgenic elite indica rice plants expressing CryIAc ∂-endotoxin of Bacillus thuringiensis are resistant against yellow stem borer (Scirpophaga incertulas)

PubMed Central

Nayak, Pritilata; Basu, Debabrata; Das, Sampa; Basu, Asitava; Ghosh, Dipankar; Ramakrishnan, Neeliyath A.; Ghosh, Maloy; Sen, Soumitra K.

1997-01-01

Generation of insect-resistant, transgenic crop plants by expression of the insecticidal crystal protein (ICP) gene of Bacillus thuringiensis (Bt) is a standard crop improvement approach. In such cases, adequate expression of the most appropriate ICP against the target insect pest of the crop species is desirable. It is also considered advantageous to generate Bt-transgenics with multiple toxin systems to control rapid development of pest resistance to the ICP. Larvae of yellow stem borer (YSB), Scirpophaga incertulas, a major lepidopteran insect pest of rice, cause massive losses of rice yield. Studies on insect feeding and on the binding properties of ICP to brush border membrane receptors in the midgut of YSB larvae revealed that cryIAb and cryIAc are two individually suitable candidate genes for developing YSB-resistant rice. Programs were undertaken to develop Bt-transgenic rice with these ICP genes independently in a single cultivar. A cryIAc gene was reconstructed and placed under control of the maize ubiquitin 1 promoter, along with the first intron of the maize ubiquitin 1 gene, and the nos terminator. The gene construct was delivered to embryogenic calli of IR64, an elite indica rice cultivar, using the particle bombardment method. Six highly expressive independent transgenic ICP lines were identified. Molecular analyses and insect-feeding assays of two such lines revealed that the transferred synthetic cryIAc gene was expressed stably in the T2 generation of these lines and that the transgenic rice plants were highly toxic to YSB larvae and lessened the damage caused by their feeding. PMID:9122157

Crowdsourcing for Challenging Technical Problems - It Works!

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2011-01-01

The NASA Johnson Space Center Space Life Sciences Directorate (SLSD) and Wyle Integrated Science and Engineering (Wyle) will conduct a one-day business cluster at the 62nd IAC so that IAC attendees will understand the benefits of open innovation (crowdsourcing), review successful results of conducting technical challenges in various open innovation projects, and learn how an organization can effectively deploy these new problem solving tools to innovate more efficiently and effectively. Results from both the SLSD open innovation pilot program and the open innovation workshop conducted by the NASA Human Health and Performance Center will be discussed. NHHPC members will be recruited to participate in the business cluster (see membership http://nhhpc.nasa.gov) and as IAF members. Crowdsourcing may be defined as the act of outsourcing tasks that are traditionally performed by an employee or contractor to an undefined, generally large group of people or community (a crowd) in the form of an open call. The open call may be issued by the organization wishing to find a solution to a particular problem or complete a task, or by an open innovation service provider on behalf of that organization. In 2008, the SLSD, with the support of Wyle, established and implemented pilot projects in open innovation (crowdsourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical challenges. These unsolved technical problems were converted to problem statements, called Challenges by some open innovation service providers, and were then posted externally to seek solutions to these problems. In addition, an open call was issued internally to NASA employees Agency wide (11 Field Centers and NASA HQ) using an open innovation service provider crowdsourcing platform to post NASA challenges from each Center for the others to propose solutions). From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external problems or challenges were posted through three different vendors: InnoCentive, yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive crowdsourcing platform designed for use internal to an organization and customized for NASA use, and promoted as NASA@Work. The results were significant. Of the seven InnoCentive external challenges, two full and five partial awards were made in complex technical areas such as predicting solar flares and long-duration food packaging.

Preparation and evaluation of a mixed-bed immunoaffinity column for selective purification of sixteen sulfonamides in pork muscle.

PubMed

Li, Yingguo; Chen, Yiqiang; Li, Zhengguo; Zhang, Lei; Li, Xianliang; Xi, Cunxian; Wang, Guomin; Wang, Xiong; Guo, Qi; Li, Na

2012-03-01

This paper describes the preparation of a novel mixed-bed immunoaffinity chromatography (IAC) column by coupling four monoclonal antibodies against different sulfonamides (SAs) to Sepharose 4B. The IAC column can be used to simultaneously extract and purify 16 SAs in pork muscle. The dynamic column capacities for all SAs in mixed standard solution were between 312 and 479 ng/mL gel. After simple extraction and IAC cleanup, the sample solution can be directly injected for liquid chromatography-ultraviolet analysis. The recoveries of SAs from spiked samples at levels of 25, 50 and 100 µg/kg ranged from 83.3 to 103.1% with variation coefficient less than 8.6%. The comparison of IAC with liquid-liquid extraction and solid phase extraction indicated that IAC has better purification effect and needs less organic solution than conventional methods, thus it would be an ideal method for selective purification of SAs in pork muscle.

Photoinduced Charge Transport Spectra for Porphyrin and Naphthalene Derivative-based Dendrimers

NASA Astrophysics Data System (ADS)

Park, J. H.; Wu, Y.; Parquette, J. R.; Epstein, A. J.

2006-03-01

Dendrimers are important chemical structures for harvesting charge. We prepared model dendrimers using two porphyrin derivatives and a naphthalene derivative. Films of these porphyrin derivatives have a strong Soret band (˜430nm) and four significant Q-bands; the naphthalene derivative has strong absorption at 365 and 383nm. Two kinds of photovoltaic cell structures [ITO/BaytronP/(thick or thin) dendrimer/Al] are constructed to investigate the optical response spectra of dendrimers under electric potential(V) on the cell (range from -1V to 2V). To obtain pure optical responses, incident light is modulated with an optical chopper and a lock-in amplifier is used to measure current (IAC) and phase (θ). For the excitation of the Soret band, IAC and θ do not change substantially with change of sign and amplitude of V. For Q-bands and naphthalene absorption bands, θ nearly follows the polarity of V on the cells and IAC is linear with V. Hence, IAC is nearly ohmic for Q- band although there are shifts due to built-in-potential. IAC for Soret band is almost same for thick and thin active layer cells. In contrast, IAC increases with thickness increase for Q bands. Mechanisms of photogeneration and charge transport will be discussed.

Prevalence and long-term clinical significance of intracranial atherosclerosis after ischaemic stroke or transient ischaemic attack: a cohort study.

PubMed

Ovesen, Christian; Abild, Annemette; Christensen, Anders Fogh; Rosenbaum, Sverre; Hansen, Christine Krarup; Havsteen, Inger; Nielsen, Jens Kellberg; Christensen, Hanne

2013-10-21

We investigated the prevalence and long-term risk associated with intracranial atherosclerosis identified during routine evaluation. This study presents data from a prospective cohort of patients admitted to our stroke unit for thrombolysis evaluation. We included 652 with a final diagnosis of ischaemic stroke or transient ischaemic attack (TIA) from April 2009 to December 2011. All patients were acutely evaluated with cerebral CT and CT angiography (CTA). Acute radiological examinations were screened for intracranial arterial stenosis (IAS) or intracranial arterial calcifications (IAC). Intracranial stenosis was grouped into 30-50%, 50-70% and >70% lumen reduction. The extent of IAC was graded as number of vessels affected. Patients were followed until July 2013. Recurrence of an ischaemic event (stroke, ischaemic heart disease (IHD) and TIA) was documented through the national chart system. Poor outcome was defined as death or recurrence of ischaemic event. 101 (15.5%) patients showed IAS (70: 30-50%, 29: 50-70% and 16: >70%). Two-hundred and fifteen (33%) patients had no IAC, 339 (52%) in 1-2 vessels and 102 (16%) in >2 vessels. During follow-up, 53 strokes, 20 TIA and 14 IHD occurred, and 95 patients died. The risk of poor outcome was significantly different among different extents of IAS as well as IAC (log-rank test p<0.01 for both). In unadjusted analysis IAS and IAC predicted poor outcome and recurrent ischaemic event. When adjusted, IAS and IAC independently increased the risk of a recurrent ischaemic event (IAS: HR 1.67; CI 1.04 to 2.64 and IAC: HR 1.22; CI 1.02 to 1.47). Intracranial atherosclerosis detected during acute evaluation predicts an increased risk of recurrent stroke.

Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model.

PubMed

Passerini, Nadia; Albertini, Beatrice; Sabatino, Marcello Di; Corace, Giuseppe; Luppi, Barbara; Canistro, Donatella; Vivarelli, Fabio; Cirillo, Silvia; Soleti, Antonio; Merizzi, Giulia; Paolini, Moreno

2016-10-15

The bis (1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate (IAC), is an innovative non- radical scavenger used with success in numerous disease models such as inflammation, neurological disorders, hepatitis and diabetes. The pharmacological treatments have been performed by the intraperitoneal route of administration, representing to date, the main limit for the drug use. The aim of this study was to develop a delivery system that allows the oral administration of IAC while maintaining its therapeutic efficacy. Solid Lipid Microparticles (SLMs) containing a theoretical 18% (w/w) of IAC have been produced by the spray congealing technology; three formulations have been tested (A, B and C) using different low melting point carriers (stearic acid, Compritol(®) HD5ATO and carnauba wax) alone or in combination. All IAC loaded SLMs exhibited a spherical shape, encapsulation efficiency higher than 94% and particle size suitable for the oral route. Administered per os at different dosages in an inflammation rat model, all SLMs demonstrated their efficacy in reducing oedema and alleviating pain, compared to the gold standards Indomethacin and Paracetamol. These results suggested that the SLMs are an efficacious delivery system for the oral administration of IAC, potentially useful for the treatment of others diseases related to an over production of free radicals. Copyright © 2016 Elsevier B.V. All rights reserved.

Development and evaluation of internal amplification controls for use in a real-time duplex PCR assay for detection of Campylobacter coli and Campylobacter jejuni.

PubMed

Randall, Luke; Lemma, Fabrizio; Rodgers, John; Vidal, Ana; Clifton-Hadley, Felicity

2010-02-01

A common problem of both conventional and real-time PCR assays is failure of DNA amplification due to the presence of inhibitory substances in samples. In view of this, our aim was to develop and evaluate internal amplification controls (IACs) for use with an existing duplex real-time PCR assay for Campylobacter coli and Campylobacter jejuni. Both competitive and non-competitive IACs were developed and evaluated. The competitive approach involved a DNA fragment of the coding region of the fish viral haemorrhagic septicaemia virus, flanked by the mapA PCR primers, whilst the non-competitive approach utilized an extra set of universal 16S rDNA primers. Both IAC-PCR assay types were evaluated using cultures of Campylobacter and chicken caecal content samples. Both IACs were sensitive to caecal inhibitors, making them suitable for detecting inhibition which could lead to false-negatives. Results showed that both IACs at optimum concentrations worked well without reducing the overall sensitivity of the PCR assay. Compared to culture, the optimized competitive IAC-PCR assay detected 45/47 positives (sensitivity 93.6 %, specificity 80.1 %); however, it had the advantage over culture in that it could detect mixed infections of C. coli and C. jejuni and was capable of giving a result for a sample within a day.

Immunization Action Coalition

MedlinePlus

... Email CDC: nipinfo@cdc.gov Contact: State Immunization Managers Email IAC: admin@immunize.org This page was ... STATE INFORMATION State Websites State Laws State Immunization Managers >> view all SUBSCRIBE SUPPORT IAC TECHNICALLY SPEAKING TRANSLATE ...

First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment.

PubMed

Munier, Francis L; Mosimann, Pascal; Puccinelli, Francesco; Gaillard, Marie-Claire; Stathopoulos, Christina; Houghton, Susan; Bergin, Ciara; Beck-Popovic, Maja

2017-08-01

The introduction of intra-arterial chemotherapy (IAC) as salvage treatment has improved the prognosis for eye conservation in group D retinoblastoma. The aim of this study was to compare the outcomes of consecutive patients with advanced unilateral disease treated with either first-line intravenous chemotherapy (IVC) or first-line IAC. This is a retrospective mono-centric comparative review of consecutive patients. Sporadic unilateral retinoblastoma group D cases treated conservatively at Jules-Gonin Eye Hospital and CHUV between 1997 and 2014. From January 1997 to August 2008, IVC, combined with focal treatments, was the primary treatment approach. From September 2008 to October 2014, IAC replaced IVC as first-line therapy. 48 patients met the inclusion criteria, receiving only either IAC or IVC as primary treatment modality. Outcomes of 23 patients treated by IVC were compared with those of 25 treated by IAC; mean follow-up was 105.3 months (range 29.2-218.6) and 41.7 months (range 19.6-89.5), respectively. Treatment duration was significantly shorter in the IAC group (p<0.001). Ten eyes in the IVC group underwent enucleation. Recordable visual acuity of the salvaged eyes was significantly better in the IAC group (0.9 vs 1.4 logarithm of the minimum angle of resolution, p<0.01). No extraocular disease, metastases or long-term systemic complications were observed in either group. The difference in the time frame between treatment groups had an impact on the availability of intravitreal chemotherapy treatment. Despite this, the results reported here imply that eyes treated with first-line IAC will have shorter treatment period, better ocular survival and visual acuity than first-line IVC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Construction Strategy for an Internal Amplification Control for Real-Time Diagnostic Assays Using Nucleic Acid Sequence-Based Amplification: Development and Clinical Application

PubMed Central

Rodríguez-Lázaro, David; D'Agostino, Martin; Pla, Maria; Cook, Nigel

2004-01-01

An important analytical control in molecular amplification-based methods is an internal amplification control (IAC), which should be included in each reaction mixture. An IAC is a nontarget nucleic acid sequence which is coamplified simultaneously with the target sequence. With negative results for the target nucleic acid, the absence of an IAC signal indicates that amplification has failed. A general strategy for the construction of an IAC for inclusion in molecular beacon-based real-time nucleic acid sequence-based amplification (NASBA) assays is presented. Construction proceeds in two phases. In the first phase, a double-stranded DNA molecule that contains nontarget sequences flanked by target sequences complementary to the NASBA primers is produced. At the 5′ end of this DNA molecule is a T7 RNA polymerase binding sequence. In the second phase of construction, RNA transcripts are produced from the DNA by T7 RNA polymerase. This RNA is the IAC; it is amplified by the target NASBA primers and is detected by a molecular beacon probe complementary to the internal nontarget sequences. As a practical example, an IAC for use in an assay for the detection of Mycobacterium avium subsp. paratuberculosis is described, its incorporation and optimization within the assay are detailed, and its application to spiked and natural clinical samples is shown to illustrate the correct interpretation of the diagnostic results. PMID:15583319

The use of immunoaffinity columns connected in tandem for selective and cost-effective mycotoxin clean-up prior to multi-mycotoxin liquid chromatographic-tandem mass spectrometric analysis in food matrices.

PubMed

Wilcox, Joyce; Donnelly, Carol; Leeman, David; Marley, Elaine

2015-06-26

This paper describes the use of two immunoaffinity columns (IACs) coupled in tandem, providing selective clean-up, based on targeted mycotoxins known to co-occur in specific matrices. An IAC for aflatoxins+ochratoxin A+fumonisins (AOF) was combined with an IAC for deoxynivalenol+zearalenone+T-2/HT-2 toxins (DZT); an IAC for ochratoxin A (O) was combined with a DZT column; and an aflatoxin+ochratoxin (AO) column was combined with a DZT column. By combining pairs of columns it was demonstrated that specific clean-up can be achieved as required for different matrices. Samples of rye flour, maize, breakfast cereal and wholemeal bread were analysed for mycotoxins regulated in the EU, by spiking at levels close to EU limits for adult and infant foods. After IAC clean-up extracts were analysed by LC-MS/MS with quantification using multiple reaction monitoring. Recoveries were found to be in range from 60 to 108%, RSDs below 10% depending on the matrix and mycotoxin combination and LOQs ranged from 0.1n g/g for aflatoxin B1 to 13.0 ng/g for deoxynivalenol. Surplus cereal proficiency test materials (FAPAS(®)) were also analysed with found levels of mycotoxins falling within the satisfactory range of concentrations (Z score ≤ ± 2), demonstrating the accuracy of the proposed multi-mycotoxin IAC methods. Copyright © 2015 Elsevier B.V. All rights reserved.

Development of an immunoaffinity column method using broad-specificity monoclonal antibodies for simultaneous extraction and cleanup of quinolone and sulfonamide antibiotics in animal muscle tissues.

PubMed

Li, Cun; Wang, Zhanhui; Cao, Xingyuan; Beier, Ross C; Zhang, Suxia; Ding, Shuangyang; Li, Xiaowei; Shen, Jianzhong

2008-10-31

This paper describes a novel mixed-bed immunoaffinity column (IAC) method. The IAC was produced by coupling anti-quinolone and anti-sulfonamide broad-specificity monoclonal antibodies to Sepharose 4B for simultaneously isolating 13 quinolones (QNs) and 6 sulfonamides (SAs) from swine and chicken muscle tissues, followed by antibiotic determination using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A new broad-specificity Mab (B1A4E8) toward sulfonamides was produced using sulfamethoxazole as hapten that demonstrated cross-reactivities to 6 SAs in the range of 31-112%. IAC optimized conditions were found that allowed the IAC to be reused for selective binding of both SAs and QNs. Recoveries of all 19 antibiotics from animal muscle ranged from 72.6 to 107.6%, with RSDs below 11.3% and 15.4% for intra-day and inter-day experiments, respectively. The limit of quantification ranged from 0.5 to 3.0ng/g. The strategy used here for a mixed-bed IAC may be used to study other compounds and more than two classes of analytes simultaneously.

Magnetic Resonance Imaging at 1.5 Tesla With a Cochlear Implant Magnet in Place: Image Quality and Usability.

PubMed

Sharon, Jeffrey D; Northcutt, Benjamin G; Aygun, Nafi; Francis, Howard W

2016-10-01

To study the quality and usability of magnetic resonance imaging (MRI) obtained with a cochlear implant magnet in situ. Retrospective chart review. Tertiary care center. All patients who underwent brain MRI with a cochlear implant magnet in situ from 2007 to 2016. None. Grade of view of the ipsilateral internal auditory canal (IAC) and cerebellopontine angle (CPA). Inclusion criteria were met by 765 image sequences in 57 MRI brain scans. For the ipsilateral IAC, significant predictors of a grade 1 (normal) view included: absence of fat saturation algorithm (p = 0.001), nonaxial plane of imaging (p = 0.01), and contrast administration (p = 0.001). For the ipsilateral CPA, significant predictors of a grade 1 view included: absence of fat saturation algorithm (p = 0.001), high-resolution images (p = 0.001), and nonaxial plane of imaging (p = 0.001). Overall, coronal T1 high-resolution images produced the highest percentage of grade 1 views (89%). Fat saturation also caused a secondary ring-shaped distortion artifact, which impaired the view of the contralateral CPA 52.7% of the time, and the contralateral IAC 42.8% of the time. MRI scans without any usable (grade 1) sequences had fewer overall sequences (N = 4.3) than scans with at least one usable sequence (N = 7.1, p = 0.001). MRI image quality with a cochlear implant magnet in situ depends on several factors, which can be modified to maximize image quality in this unique patient population.

Industrial Assessment Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dr. Diane Schaub

2007-03-05

Since its inception, the University of Florida Industrial Assessment Center has successfully completed close to 400 energy assessments of small to medium manufacturing facilities in Florida, southern Georgia and southern Alabama. Through these efforts, recommendations were made that would result in savings of about $5 million per year, with an implementation rate of 20-25%. Approximately 80 engineering students have worked for the UF-IAC, at least 10 of whom went on to work in energy related fields after graduation. Additionally, through the popular course in Industrial Energy Management, many students have graduated from the University of Florida with a strong understandingmore » and support of energy conservation methods.« less

Characterization of Antixenosis in Soybean Genotypes to Bemisia tabaci (Hemiptera: Aleyrodidae) Biotype B.

PubMed

Baldin, E L L; Cruz, P L; Morando, R; Silva, I F; Bentivenha, J P F; Tozin, L R S; Rodrigues, T M

2017-08-01

Bemisia tabaci biotype B (Gennadius) is one of the most important soybean pest worldwide. Herein, 15 soybean genotypes were evaluated, to characterize the occurrence of antixenosis to B. tabaci biotype B. Initially, a multiple-choice test with all genotypes was carried out, evaluating the settling and oviposition preference at 3 d after infestation, and the colonization by nymphs after 48 d of infestation. Subsequently, a no-choice test, using 14 genotypes, was conducted with infested plants individually, and the number of eggs was counted after 72 h. Then, 10 genotypes were selected (indicative of resistance and susceptibility), which were evaluated for whitefly settling 24, 48, and 72 h after infestation and for oviposition 72 h after infestation. The trichomes of the leaflets were characterized for density, size, and inclination to establish possible correlations with the settling and oviposition in the genotypes. In the first multiple-choice test, involving 15 genotypes, 'IAC-17,' 'IAC-19,' and UX-2569-159 expressed antixenosis against B. tabaci. 'Jackson,' 'P98Y11,' and PI-229358 exhibited the same behavior in the no-choice test. In the multiple-choice test, 'Jackson,' 'P98Y11,' and 'TMG1176 RR' were the least attractive and least used for oviposition. The antixenosis shown by 'Jackson,' 'P98Y11,' and PI-229358 may be related to the characteristics of the trichomes (lower density and inclined). Based on the experiments carried out, 'IAC-17,' 'IAC-19,' 'Jackson,' 'P98Y11,' PI-229358, TMG1176 RR, and UX-2569-159 are considered promising for resistance to B. tabaci biotype B and may be exploited in soybean breeding programs for resistance to insects. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis.

PubMed

Wenham, C Y J; Balamoody, S; Grainger, A J; Hensor, E M A; Draycott, S; Hodgson, R; Conaghan, P G

2014-10-01

Sensitive biomarkers are needed to understand synovial response to therapy in osteoarthritis (OA). Dynamic, contrast-enhanced magnetic resonance imaging (DCE MRI) provides quantitative, novel measures of synovial inflammation. This exploratory study examined DCE-assessed synovial response to intra-articular corticosteroid (IACS). People with ACR clinical criteria OA knee underwent 3 T MRI pre- and 2 weeks post-IACS. Five MRI variables were assessed blindly: total synovial volume (semi-automated computer program), early enhancement rate (EER) and late enhancement ratio of the entire knee, synovial volume × late enhancement and a semi-quantitative (SQ) score (six sites scored 0-3). Clinical symptoms were assessed using pain visual analogue score (VAS) and WOMAC. 13 participants (5 male, mean age 63, mean pain VAS 66 mm mean body mass index (BMI) 31.3 kg/m(2)) were included. The majority of MRIs demonstrated no change in SQ score although the DCE variables changed to some extent in all. There was generally a reduction in synovial volume ((Wilcoxon test) median (interquartile range (IQR)) reduction 14 cm(3) (-1, 29)), EER (0.2% (-0.3, 0.6)) and late enhancement ratio (8% (-0.5, 41)). Synovial volume × late enhancement ratio demonstrated a substantive reduction (2250 (-930, 5630)) as well as the largest effect size, r = 0.45. There was a median 26% reduction in EER in participants with good symptomatic response to IACS, contrasting with a 23% increase in those who responded poorly. DCE MRI may be more sensitive than a SQ score at detecting post-therapy synovial changes. The association between EER and symptomatic response to IACS may reflect a closer relation of this biomarker to synovial inflammation than with volumetric assessment. Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Cortical integrity of the inferior alveolar canal as a predictor of paresthesia after third-molar extraction.

PubMed

Park, Wonse; Choi, Ji-Wook; Kim, Jae-Young; Kim, Bong-Chul; Kim, Hyung Jun; Lee, Sang-Hwy

2010-03-01

Paresthesia is a well-known complication of extraction of mandibular third molars (MTMs). The authors evaluated the relationship between paresthesia after MTM extraction and the cortical integrity of the inferior alveolar canal (IAC) by using computed tomography (CT). The authors designed a retrospective cohort study involving participants considered, on the basis of panoramic imaging, to be at high risk of experiencing injury of the inferior alveolar nerve who subsequently underwent CT imaging and extraction of the MTMs. The primary predictor variable was the contact relationship between the IAC and the MTM as viewed on a CT image, classified into three groups: group 1, no contact; group 2, contact between the MTM and the intact IAC cortex; group 3, contact between the MTM and the interrupted IAC cortex. The secondary predictor variable was the number of CT image slices showing the cortical interruption around the MTM. The outcome variable was the presence or absence of postoperative paresthesia after MTM extraction. The study sample comprised 179 participants who underwent MTM extraction (a total of 259 MTMs). Their mean age was 23.6 years, and 85 (47.5 percent) were male. The overall prevalence of paresthesia was 4.2 percent (11 of 259 teeth). The prevalence of paresthesia in group 3 (involving an interrupted IAC cortex) was 11.8 percent (10 of 85 cases), while for group 2 (involving an intact IAC cortex) and group 1 (involving no contact) it was 1.0 percent (1 of 98 cases) and 0.0 percent (no cases), respectively. The frequency of nerve damage increased with the number of CT image slices showing loss of cortical integrity (P=.043). The results of this study indicate that loss of IAC cortical integrity is associated with an increased risk of experiencing paresthesia after MTM extraction.

An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

PubMed

Molina, Jennifer R; Sun, Yuting; Protopopova, Marina; Gera, Sonal; Bandi, Madhavi; Bristow, Christopher; McAfoos, Timothy; Morlacchi, Pietro; Ackroyd, Jeffrey; Agip, Ahmed-Noor A; Al-Atrash, Gheath; Asara, John; Bardenhagen, Jennifer; Carrillo, Caroline C; Carroll, Christopher; Chang, Edward; Ciurea, Stefan; Cross, Jason B; Czako, Barbara; Deem, Angela; Daver, Naval; de Groot, John Frederick; Dong, Jian-Wen; Feng, Ningping; Gao, Guang; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Giuliani, Virginia; Han, Jing; Han, Lina; Henry, Verlene K; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Khor, Tin; Konoplev, Sergej; Lin, Yu-Hsi; Liu, Gang; Lodi, Alessia; Lofton, Timothy; Ma, Helen; Mahendra, Mikhila; Matre, Polina; Mullinax, Robert; Peoples, Michael; Petrocchi, Alessia; Rodriguez-Canale, Jaime; Serreli, Riccardo; Shi, Thomas; Smith, Melinda; Tabe, Yoko; Theroff, Jay; Tiziani, Stefano; Xu, Quanyun; Zhang, Qi; Muller, Florian; DePinho, Ronald A; Toniatti, Carlo; Draetta, Giulio F; Heffernan, Timothy P; Konopleva, Marina; Jones, Philip; Di Francesco, M Emilia; Marszalek, Joseph R

2018-06-11

Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to an incomplete understanding of tumor contexts in which OXPHOS is essential. Here, we report the discovery of IACS-010759, a clinical-grade small-molecule inhibitor of complex I of the mitochondrial electron transport chain. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis. In models of brain cancer and AML, tumor growth was potently inhibited in vivo following IACS-010759 treatment at well-tolerated doses. IACS-010759 is currently being evaluated in phase 1 clinical trials in relapsed/refractory AML and solid tumors.

Proceedings of the NASTRAN (Tradename) Users’ Colloquium (14th) Held in San Diego, California on 5-9 May 1986

DTIC Science & Technology

1986-05-01

4. Bossi, J. A., Price, G. A., and Winkleblack, S. A., " Flexible Spacecraft Controller Design Using the Integrated Analysis Capability (IAC)," AIAA...P., "Integrated Control System Design Capabilities at the Goddard Space Flight Center," Pro- ceedings of the 2nd IEEE Control Systems Society...Symposium on Computer- Aided Control System Design (CACSD), Santa Barbara, California, March, 13-15 1985. 6. Frisch, H. P. "Integrated Analysis Capability

78 FR 63093 - Approval and Promulgation of Air Quality Implementation Plans; Indiana

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... section of 326 IAC Article 7 concerning sulfur dioxide compliance monitoring requirements. On September 6... monitoring and sulfur dioxide control requirements in Indiana SIP. In addition to 326 IAC 1-2-23.5, the State... 63095

Protocol for Removal of Third Molar Root Tips from the Inferior Alveolar Canal-Crossing the line.

PubMed

Punga, Rohit; Keswani, Kiran

2014-12-01

The safe removal of third molars involved with the inferior alveolar canal (IAC) has been an area of concern since long. Many times we hesitate for the removal of third molars, fearing injury to the inferior alveolar nerve. The authors here describe a simple technique which can be used to remove third molars showing evidence of proximity to IAC on presurgical radiographic evaluation, as well as those root tips which, during removal, accidentally enter the IAC space. A step-by-step protocol is presented along with necessary precautions during the operative procedure.

BrainIACS: a system for web-based medical image processing

NASA Astrophysics Data System (ADS)

Kishore, Bhaskar; Bazin, Pierre-Louis; Pham, Dzung L.

2009-02-01

We describe BrainIACS, a web-based medical image processing system that permits and facilitates algorithm developers to quickly create extensible user interfaces for their algorithms. Designed to address the challenges faced by algorithm developers in providing user-friendly graphical interfaces, BrainIACS is completely implemented using freely available, open-source software. The system, which is based on a client-server architecture, utilizes an AJAX front-end written using the Google Web Toolkit (GWT) and Java Servlets running on Apache Tomcat as its back-end. To enable developers to quickly and simply create user interfaces for configuring their algorithms, the interfaces are described using XML and are parsed by our system to create the corresponding user interface elements. Most of the commonly found elements such as check boxes, drop down lists, input boxes, radio buttons, tab panels and group boxes are supported. Some elements such as the input box support input validation. Changes to the user interface such as addition and deletion of elements are performed by editing the XML file or by using the system's user interface creator. In addition to user interface generation, the system also provides its own interfaces for data transfer, previewing of input and output files, and algorithm queuing. As the system is programmed using Java (and finally Java-script after compilation of the front-end code), it is platform independent with the only requirements being that a Servlet implementation be available and that the processing algorithms can execute on the server platform.

Development and Application of Immunoaffinity Chromatography for Coplanar PCBs in Soil and Sediment

EPA Science Inventory

An immunoaffinity chromatography (IAC) column was developed as a simple cleanup procedure for preparing environmental samples for analysis of polychlorinated biphenyls (PCBs). Soil and sediment samples were prepared using pressurized liquid extraction (PLE), followed by the IAC c...

Treatment fidelity instrument to measure a brief opportunistic intervention for prenatal substance use.

PubMed

Torrey, Antonia Rae

2012-01-01

To develop and psychometrically evaluate an instrument designed to measure the treatment fidelity associated with implementation of the I Am Concerned (IAC) brief opportunistic intervention by frontline, prenatal, primary care staff. A methodologic approach framed development of the IAC Treatment Fidelity Instrument in a six-phase protocol. A simulated prenatal clinic with standardized patients portraying substance-using pregnant women. Prenatal, primary care, frontline staff (N = 6), experienced in IAC implementation. Following development of the IAC treatment fidelity instrument, independent raters used the instrument to evaluate audio recordings (N = 49) of frontline staff implementing the IAC brief opportunistic intervention with standardized patients representing substance-using pregnant women. Psychometric analysis provided evidence of content validity. Intraclass correlation coefficients calculated for inter-rater reliability were satisfactory for subscales (0.64) and (0.62) and ranged from -0.07 to 0.81 for individual items. Internal consistency alpha coefficients were satisfactory for the total scale (0.72) and lower than acceptable for adherence (0.54) and competence (0.56) subscales. Overall high rater percentage agreement and negatively skewed ratings distribution indicated reliability results were paradoxically low due to the base rate problem. Results support revision and ongoing testing of the IAC treatment fidelity instrument. The impact on reliability statistics exerted by this study's skewed data distribution has implications for nursing research as low variance can be anticipated when measuring care provided to homogenous patient populations. It is important to recognize the resulting influence on inter-rater agreement to avoid making inaccurate interpretations about the reliability of an instrument's measurements. © 2012 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

Delineating the role of multiple intraarticular corticosteroid injections in the management of juvenile idiopathic arthritis in the biologic era.

PubMed

Papadopoulou, Charalampia; Kostik, Mikhail; Gonzalez-Fernandez, Maria Isabel; Bohm, Marek; Nieto-Gonzalez, Juan Carlos; Pistorio, Angela; Lanni, Stefano; Consolaro, Alessandro; Martini, Alberto; Ravelli, Angelo

2013-07-01

To investigate the outcome and predicting factors of multiple intraarticular corticosteroid (IAC) injections in children with juvenile idiopathic arthritis (JIA). The clinical charts of patients who received their first IAC injection in ≥3 joints between January 2002 and December 2011 were reviewed. The corticosteroid used was triamcinolone hexacetonide for large joints and methylprednisolone acetate for small or difficult to access joints. In each patient, the followup period after IAC injection was censored in case of synovitis flare or at the last visit with continued remission. Predictors included sex, age at disease onset, JIA category, antinuclear antibody (ANA) status, age and disease duration, disease course, general anesthesia, number and type of injected joints, acute-phase reactants, and concomitant systemic medications. A total of 220 patients who had 1,096 joints injected were included. Following IAC therapy, 66.4% of patients had synovitis flare after a median of 0.5 years, whereas 33.6% of patients had sustained remission after a median of 0.9 years. The cumulative probability of survival without synovitis flare was 50.0%, 31.5%, and 19.5% at 1, 2, and 3 years, respectively. On Cox regression analysis, positive C-reactive protein value, negative ANA, lack of concomitant methotrexate administration, and a polyarticular (versus an oligoarticular) disease course were the strongest predictors for synovitis flare. Multiple IAC injection therapy induced sustained remission of joint synovitis in a substantial proportion of patients. A controlled trial comparing multiple IAC injection therapy and methotrexate versus methotrexate and a tumor necrosis factor antagonist is worthy of consideration. Copyright © 2013 by the American College of Rheumatology.

The Value of Quality Improvement Process in the Detection and Correction of Common Errors in Echocardiographic Hemodynamic Parameters in a Busy Echocardiography Laboratory

PubMed Central

Fanari, Zaher; Choudhry, Usman I; Reddy, Vivek K; Eze-Nliam, Chete; Hammami, Sumaya; Kolm, Paul; Weintraub, William S.; Marshall, Erik S

2015-01-01

Background Accurate assessment of cardiac structures, ventricular function, and hemodynamics are essential for any echocardiographic laboratory. Quality Improvement (QI) processes described by the American Society of Echocardiography (ASE) and the Intersocietal Commission (IAC) should be instrumental in reaching this goal. Methods All patients undergoing transthoracic echocardiogram (TTE) followed by cardiac catheterization within 24 hours at Christiana Care Health System in 2011 and 2012 were identified, with 126 and 133 cases respectively. Hemodynamic parameters of diastolic function, Pulmonary Artery Systolic Pressure (PASP) on TTE correlated poorly with catheterization in 2011. An educational process was developed and implemented at quarterly QI meetings based on ASE and IAC recommendations to target frequently encountered errors and provide methods for improved performance. The hemodynamic parameters were then re-examined in 2012 post-intervention. Results Following the QI process, there was significant improvement in the correlation between invasive and echocardiographic hemodynamic measurements in both systolic and diastolic function, and PASP. This reflected in significant better correlations between echo and cath LVEF [R = 0.88, ICC=0.87 vs. R = 0.85, ICC=0.85; p <0.001], Average E/E’ and of left Ventricle End Diastolic Pressure (LVEDP) [R = 0.62vs. R = 0.09, p = 0.006] and a better correlation for PASP [R= 0.77, ICC=0.77 vs. R = 0.30, ICC=0.31; p = 0.05] in 2012 compared to 2011. Conclusion The QI process, as recommended by ASE and IAC, can allow for identification as well as rectification of quality issues in a large regional academic medical center hospital. PMID:26033297

Atlas instrumentation guided by the medial edge of the posterior arch: An anatomic and radiologic study.

PubMed

Al-Habib, Amro F; Al-Rabie, Abdulkarim; Aleissa, Sami; Albakr, Abdulrahman; Abobotain, Abdulaziz

2017-01-01

This was an interventional human cadaver study and radiological study. Atlas instrumentation is frequently involved in fusion procedures involving the craniocervical junction area. Identification of the entry point at the center of atlas lateral mass (ALM) is challenging because of its rounded posterior surface and the surrounding venous plexus. This report examines using the medial edge of atlas posterior arch (MEC1) as a fixed and reliable anatomic reference to guide the entry point of ALM screws. Fifty, normal, cervical spine computed tomography studies were reviewed. ALM screw trajectories were planned at one point along MEC1 and another point 2 mm lateral to MEC1. Free-hand ALM instrumentation was performed in ten fresh human cadavers using the 2 mm entry point, with a sagittal trajectory parallel to atlas inferior arch (IAC1); three-dimensional imaging was then performed to confirm instrumentation accuracy. The average ALM diameter was 12.35 mm. Inserting a screw using the entry point 2 mm lateral to MEC1 was closer to ALM midpoint than using the entry point along MEC1 ( P < 0.0001). Twenty ALM screws were successfully inserted in the ten cadavers. No encroachments into the spinal canal or foramen transversarium occurred. However, two screws were superiorly directed and violated the occipitocervical joint; they were not parallel to IAC1. MEC1 provides a fixed and reliable landmark for ALM instrumentation. An entry point 2 mm point lateral to MEC1 is close to ALM midpoint. IAC1 also provides a guide for the sagittal trajectory. Attention to anatomic landmarks may help reduce complications associated with atlas instrumentation but should be verified in future clinical studies.

The Value of Quality Improvement Process in the Detection and Correction of Common Errors in Echocardiographic Hemodynamic Parameters in a Busy Echocardiography Laboratory.

PubMed

Fanari, Zaher; Choudhry, Usman I; Reddy, Vivek K; Eze-Nliam, Chete; Hammami, Sumaya; Kolm, Paul; Weintraub, William S; Marshall, Erik S

2015-12-01

Accurate assessment of cardiac structures, ventricular function, and hemodynamics is essential for any echocardiographic laboratory. Quality improvement (QI) processes described by the American Society of Echocardiography (ASE) and the Intersocietal Commission (IAC) should be instrumental in reaching this goal. All patients undergoing transthoracic echocardiogram (TTE) followed by cardiac catheterization within 24 hours at Christiana Care Health System in 2011 and 2012 were identified, with 126 and 133 cases, respectively. Hemodynamic parameters of diastolic function and pulmonary artery systolic pressure (PASP) on TTE correlated poorly with catheterization in 2011. An educational process was developed and implemented at quarterly QI meetings based on ASE and IAC recommendations to target frequently encountered errors and provide methods for improved performance. The hemodynamic parameters were then reexamined in 2012 postintervention. Following the QI process, there was significant improvement in the correlation between invasive and echocardiographic hemodynamic measurements in both systolic and diastolic function, and PASP. This reflected in significant better correlations between echo and cath LVEF [R = 0.88, ICC = 0.87 vs. R = 0.85, ICC = 0.85; P < 0.001], average E/E' and of left ventricle end-diastolic pressure (LVEDP) [R = 0.62 vs. R = 0.09, P = 0.006] and a better correlation for PASP [R = 0.77, ICC = 0.77 vs. R = 0.30, ICC = 0.31; P = 0.05] in 2012 compared to 2011. The QI process, as recommended by ASE and IAC, can allow for identification as well as rectification of quality issues in a large regional academic medical center hospital. © 2015, Wiley Periodicals, Inc.

Quantitative Inspection Technologies for Aging Military Aircraft

DTIC Science & Technology

2013-11-01

Continue exploring the application of THz/FTIR for advanced aerospace materials, e.g., Thermal Barrier Coatings (TBCs) and Ceramic Matrix Composites...With On-Board Impedance- Matching Buffers ...Specimen. The Inverted Foil Conductivity Of 1.348%IACS Agrees With The DCPD Value Of 1.342%IACS

Modeling the Frozen-In Anticyclone in the 2005 Arctic Summer Stratosphere

NASA Technical Reports Server (NTRS)

Allen, D. R.; Douglass, A. R.; Manney, G. L.; Strahan, S. E.; Krosschell, J. C.; Trueblood, J.

2010-01-01

Immediately following the breakup of the 2005 Arctic spring stratospheric vortex, a tropical air mass, characterized by low potential vorticity (PV) and high nitrous oxide (N2O), was advected poleward and became trapped in the easterly summer polar vortex. This feature, known as a "Frozen-In Anticyclone (FrIAC)", was observed in Earth Observing System (EOS) Aura Microwave Limb Sounder (MLS) data to span the potential temperature range from approximately 580 to 1100 K (approximately 25 to 40 km altitude) and to persist from late March to late August 2005. This study compares MLS N2O observations with simulations from the Global Modeling Initiative (GMI) chemistry and transport model, the GEOS-5/MERRA Replay model, and the VanLeer Icosahedral Triangular Advection isentropic transport model to elucidate the processes involved in the lifecycle of the FrIAC which is here divided into three distinct phases. During the "spin-up phase" (March to early April), strong poleward flow resulted in a tight isolated anticyclonic vortex at approximately 70-90 deg N, marked with elevated N2O. GMI, Replay, and VITA all reliably simulted the spin-up of the FrIAC, although the GMI and Replay peak N2O values were too low. The FrIAC became trapped in the developing summer easterly flow and circulated around the polar region during the "anticyclonic phase" (early April to the end of May). During this phase, the FrIAC crossed directly over the pole between the 7th and 14th of April. The VITA and Replay simulations transported the N2O anomaly intact during this crossing, in agreement with MLS, but unrealistic dispersion of the anomaly occurred in the GMI simulation due to excessive numerical mixing of the polar cap. The vortex associated with the FrIAC was apparently resistant to the weak vertical hear during the anticyclonic phase, and it thereby protected the embedded N20 anomaly from stretching. The vortex decayed in late May due to diabatic processes, leaving the N2O anomaly exposed to horizontal and vertical wind shears during the "shearing phase" (June to August). The observed lifetime of the FrIAC during this phase is consistent with time-scales calculated from the ambient horizontal and vertical wind shear. Replay maintained the horizontal structure of the N2O anomaly similar to NILS well into August. The VITA simulation also captured the horizontal structure of the FrIAC during this phase, but VITA eventually developed fine-scale N2O structure not observed in MLS data.

Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells

PubMed Central

Vangapandu, Hima V.; Alston, Brandon; Morse, Joshua; Ayres, Mary L.; Wierda, William G.; Keating, Michael J.; Marszalek, Joseph R.; Gandhi, Varsha

2018-01-01

Blood cells from patients with chronic lymphocytic leukemia (CLL) are replicationally quiescent but transcriptionally, translationally, and metabolically active. Recently, we demonstrated that oxidative phosphorylation (OxPhos) is a predominant pathway in CLL for energy production and is further augmented in the presence of the stromal microenvironment. Importantly, CLL cells from patients with poor prognostic markers showed increased OxPhos. From these data, we theorized that OxPhos can be targeted to treat CLL. IACS-010759, currently in clinical development, is a small-molecule, orally bioavailable OxPhos inhibitor that targets mitochondrial complex I. Treatment of primary CLL cells with IACS-010759 greatly inhibited OxPhos but caused only minor cell death at 24 and 48 h. In the presence of stroma, the drug successfully inhibited OxPhos and diminished intracellular ribonucleotide pools. However, glycolysis and glucose uptake were induced as compensatory mechanisms. To mitigate the upregulated glycolytic flux, we used 2-deoxy-D-glucose in combination with IACS-010759. This combination reduced both OxPhos and glycolysis and induced cell death. Consistent with these data, low-glucose culture conditions sensitized CLL cells to IACS-010759. Collectively, these data suggest that CLL cells adapt to use a different metabolic pathway when OxPhos is inhibited and that targeting both OxPhos and glycolysis pathways is necessary for biological effect. PMID:29861847

The interplay between siderophore secretion and coupled iron and copper transport in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120.

PubMed

Nicolaisen, Kerstin; Hahn, Alexander; Valdebenito, Marianne; Moslavac, Suncana; Samborski, Anastazia; Maldener, Iris; Wilken, Corinna; Valladares, Ana; Flores, Enrique; Hantke, Klaus; Schleiff, Enrico

2010-11-01

Iron uptake is essential for Gram-negative bacteria including cyanobacteria. In cyanobacteria, however, the iron demand is higher than in proteobacteria due to the function of iron as a cofactor in photosynthesis and nitrogen fixation, but our understanding of iron uptake by cyanobacteria stands behind the knowledge in proteobacteria. Here, two genes involved in this process in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120 were identified. ORF all4025 encodes SchE, a putative cytoplasmic membrane-localized transporter involved in TolC-dependent siderophore secretion. Inactivation of schE resulted in an enhanced sensitivity to high metal concentrations and decreased secretion of hydroxamate-type siderophores. ORF all4026 encodes a predicted outer membrane-localized TonB-dependent iron transporter, IacT. Inactivation of iacT resulted in decreased sensitivity to elevated iron and copper levels. Expression of iacT from the artificial trc promoter (P(trc)) resulted in sensitization against tested metals. Further analysis showed that iron and copper effects are synergistic because a decreased supply of iron induced a significant decrease of copper levels in the iacT insertion mutant but an increase of those levels in the strain carrying P(trc)-iacT. Our results unravel a link between iron and copper homeostasis in Anabaena sp. PCC 7120. Copyright © 2010 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hidalgo, Sebastian L.; Aparicio, Antonio; MartInez-Delgado, David

We present the star formation history (SFH) and its variations with galactocentric distance for the Local Group dwarf galaxy of Phoenix. They have been derived from a (F555W, F814W) color-magnitude diagram obtained from WFPC2-HST data, which reaches the oldest main-sequence turnoffs. The IAC-star and IAC-pop codes and the MinnIAC suite have been used to obtain the star formation rate as a function of time and metallicity, psi(t, z). We find that Phoenix has had ongoing but gradually decreasing star formation over nearly a Hubble time. The highest level of star formation occurred from the formation of the galaxy till 10.5more » Gyr ago, when 50% of the total star formation had already taken place. From that moment, star formation continues at a significant level until 6 Gyr ago (an additional 35% of the stars are formed in this time interval), and at a very low level till the present time. The chemical enrichment law shows a trend of slowly increasing metallicity as a function of time until 6-8 Gyr ago, when metallicity starts to increase steeply to the current value. We have paid particular attention to the study of the variations of the SFH as a function of radius. Young stars are found in the inner region of the galaxy only, but intermediate-age and old stars can be found at all galactocentric distances. The distribution of mass density in alive stars and its evolution with time has been studied. This study shows that star formation started at all galactocentric distances in Phoenix at an early epoch. If stars form in situ in Phoenix, the star formation onset took place all over the galaxy (up to a distance of about 400 pc from the center), but preferentially out of center regions. After that, our results are compatible with a scenario in which the star formation region envelope slowly shrinks as time goes on, possibly as a natural result of pressure support reduction as gas supply diminishes. As a consequence, the star formation stopped first (about 7-8 Gyr ago) in outer regions and the scale length of the stellar mass density distribution decreased with time. Finally, no traces of a true, old halo are apparent in Phoenix either in its stellar age distribution or in the stellar mass density distribution, at least out to 0.5 kpc (about 2.5 scale length) from the center.« less

49 CFR 1515.9 - Appeal of security threat assessment based on other analyses.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., foreign air carriers, indirect air carriers (IACs), certified cargo screening facilities, or validation...'s reply and any accompanying information, and any other materials or information available to him or... operators, foreign air carriers, IACs, certified cargo screening facilities, or validation firms. [72 FR...

THERMOOXIDATIVE STUDY OF RAW NATURAL RUBBER FROM BRAZILIAN IAC 300 SERIES CLONES

USDA-ARS?s Scientific Manuscript database

The improvement of rubber tree species is of key importance due to the worldwide market demand of this renewable material essential for several types of industries. The thermal performance of natural rubber produced from new clones of IAC 300 series, and the Malaysian RRIM 600 clone (used as control...

Development of a recombinase polymerase amplification assay for Vibrio parahaemolyticus detection with an internal amplification control.

PubMed

Yang, Huan-Lan; Wei, Shuang; Gooneratne, Ravi; Mutukumira, Anthony N; Ma, Xue-Jun; Tang, Shu-Ze; Wu, Xi-Yang

2018-04-01

A novel RPA-IAC assay using recombinase polymerase and an internal amplification control (IAC) for Vibrio parahaemolyticus detection was developed. Specific primers were designed based on the coding sequence for the toxR gene in V. parahaemolyticus. The recombinase polymerase amplification (RPA) reaction was conducted at a constant low temperature of 37 °C for 20 min. Assay specificity was validated by using 63 Vibrio strains and 10 non-Vibrio bacterial species. In addition, a competitive IAC was employed to avoid false-negative results, which co-amplified simultaneously with the target sequence. The sensitivity of the assay was determined as 3 × 10 3 CFU/mL, which is decidedly more sensitive than the established PCR method. This method was then used to test seafood samples that were collected from local markets. Seven out of 53 different raw seafoods were detected as V. parahaemolyticus-positive, which were consistent with those obtained using traditional culturing method and biochemical assay. This novel RPA-IAC assay provides a rapid, specific, sensitive, and more convenient detection method for V. parahaemolyticus.

Effects of gamma-irradiation before and after cooking on bacterial population and sensory quality of Dakgalbi

NASA Astrophysics Data System (ADS)

Yoon, Young Min; Park, Jong-Heum; Lee, Ji-Hye; Park, Jae-Nam; Park, Jin-Kyu; Sung, Nak-Yun; Song, Beom-Seok; Kim, Jae-Hun; Yoon, Yohan; Gao, Meixu; Yook, Hong-Sun; Lee, Ju-Woon

2012-08-01

The purpose of this study was to compare the effect of gamma irradiation on the total bacterial population and the sensory quality of Dakgalbi irradiated before and after cooking. Fresh chicken meat was cut into small pieces and used to prepare Dakgalbi. For the preparation of Dakgalbi cooked with gamma-irradiated chicken meat and sauce (IBC), raw chicken meat and Dakgalbi sauce were irradiated and then stir-fried. For the preparation of Dakgalbi irradiated after cooking with raw chicken meat and sauce (IAC), raw chicken meat and Dakgalbi sauce were first cooked and subsequently irradiated. Under the accelerated storage condition of 35 °C for 7 days, bacteria in IBC were below the detection limit (1 log CFU/g) on day 1 but were detected on day 2 and gradually increased hereafter. In IAC, on the other hand, bacteria were not detected at all. Evaluation of sensory quality also decreased on both samples. However, IAC showed a better trend. Our results indicate that IAC protocol was a more effective method for reducing bacterial growth in Dakgalbi.

A climatology of frozen-in anticyclones in the spring arctic stratosphere over the period 1960-2011

NASA Astrophysics Data System (ADS)

ThiéBlemont, RéMi; Orsolini, Yvan J.; Hauchecorne, Alain; Drouin, Marc-Antoine; Huret, Nathalie

2013-02-01

During springtime, following the stratospheric final warming, intrusions from low latitudes can become trapped at polar latitudes in long-lived anticyclones. Such "frozen-in" anticyclones (FrIACs) have occasionally been observed to persist as late as August, advected by summer easterlies. In this study, the high-resolution advection contour model MIMOSA is used to advect a pseudo-potential vorticity tracer. The model is driven by ERA-40 and the ERA-Interim reanalyses over the period 1960-2011. We first identify a remarkable FrIAC event in spring 2011. In addition, we developed a method to detect the characteristic size of low-latitude intrusions into the polar region at the time of the spring transition, over the period 1960-2011. Years are classified as either Type-A when the intrusions are small or as Type-B when intrusions are large, potentially evolving into FrIACs. For a FrIAC to occur, we require an additional criterion based on the in-phase character of the core of the intrusions and the anticyclone. During the 52 analyzed years, 9 events have been identified: 1 in the 1960s, 1 in the 1980s, 2 in the 1990s, and 5 from 2002. FrIAC are predominantly long-lived intrusions, which occur in association with abrupt and early reversal to summer easterlies with a large heat flux pulse around the date of this wind reversal. Finally, the results are discussed in a climatological context.

A Climatology of Frozen-In Anticyclones in the Spring Arctic Stratosphere over the Period 1960-2011

NASA Astrophysics Data System (ADS)

Thiéblemont, Rémi; Orsolini, Yvan J.; Huret, Nathalie; Hauchecorne, Alain; Drouin, Marc-Antoine

2013-04-01

During springtime, following the stratospheric final warming, intrusions from low latitudes can become trapped at polar latitudes in long-lived anticyclones. Such "frozen-in" anticyclones (FrIACs) have occasionally been observed to persist as late as August, advected by summer easterlies. In this study, the high-resolution advection contour model MIMOSA is used to advect a pseudo-potential vorticity tracer. The model is driven by ERA-40 and the ERA-Interim reanalyses over the period 1960-2011. We first identify a remarkable FrIAC event in spring 2011. In addition, we developed a method to detect the characteristic size of low-latitude intrusions into the polar region at the time of the spring transition, over the period 1960-2011. Years are classified as either Type-A when the intrusions are small, or as Type-B when intrusions are large, potentially evolving into FrIACs. For a FrIAC to occur, we require an additional criterion based on the in-phase character of the core of the intrusions and the anticyclone. During the 52 analysed years, 9 events have been identified: 1 in the 1960s, 1 in the 1980s, 2 in the 1990s and 5 from 2002. FrIAC are predominantly long-lived intrusions, which occur in association with abrupt and early reversal to summer easterlies with a large heat flux pulse around the date of this wind reversal. Finally, the results are discussed in a climatological context.

Use of piezosurgery for internal auditory canal drilling in acoustic neuroma surgery.

PubMed

Grauvogel, Juergen; Scheiwe, Christian; Kaminsky, Jan

2011-10-01

Piezosurgery is based on microvibrations generated by the piezoelectrical effect and has a selective bone-cutting ability with preservation of soft tissue. This study examined the applicability of Piezosurgery compared to rotating drills (RD) for internal auditory canal (IAC) opening in acoustic neuroma (AN) surgery. Piezosurgery was used in eight patients for IAC drilling in AN surgery. After exposition of the IAC and tumor, the posterior wall of the IAC was drilled using Piezosurgery instead of RD. Piezosurgery was evaluated with respect to practicability, safety, preciseness of bone cutting, preservation of cranial nerves, influences on neurophysiological monitoring, and facial nerve and hearing outcome. Piezosurgery was successfully used for selective bone cutting, while cranial nerves were structurally and functionally preserved, which could be measured by means of neuromonitoring. Piezosurgery guaranteed a safe and precise cut by removing bone layer by layer in a shaping way. Compared to RD, limited influence on neurophysiological monitoring attributable to Piezosurgery was noted, allowing for continuous neuromonitoring. No disadvantage due to microvibrations was noticed concerning hearing function. The angled tip showed better handling in right-sided than in left-sided tumors in the hands of a right-handed surgeon. The short, thick handpiece may be improved for more convenient handling. Piezosurgery is a safe tool for selective bone cutting for opening of the IAC with preservation of facial nerve and hearing function in AN surgery. Piezosurgery has the potential to replace RD for this indication because of its safe and precise bone-cutting properties.

Value of intracochlear electrically evoked auditory brainstem response after cochlear implantation in patients with narrow internal auditory canal.

PubMed

Song, Mee Hyun; Bae, Mi Ran; Kim, Hee Nam; Lee, Won-Sang; Yang, Won Sun; Choi, Jae Young

2010-08-01

Cochlear implantation in patients with narrow internal auditory canal (IAC) can result in variable outcomes; however, preoperative evaluations have limitations in accurately predicting outcomes. In this study, we analyzed the outcomes of cochlear implantation in patients with narrow IAC and correlated the intracochlear electrically evoked auditory brainstem response (EABR) findings to postoperative performance to determine the prognostic significance of intracochlear EABR. Retrospective case series at a tertiary hospital. Thirteen profoundly deaf patients with narrow IAC who received cochlear implantation from 2002 to 2008 were included in this study. Postoperative performance was evaluated after at least 12 months of follow-up, and postoperative intracochlear EABR was measured to determine its correlation with outcome. The clinical significance of electrically evoked compound action potential (ECAP) was also analyzed. Patients with narrow IAC showed postoperative auditory performances ranging from CAP 0 to 4 after cochlear implantation. Intracochlear EABR measured postoperatively demonstrated prognostic value in the prediction of long-term outcomes, whereas ECAP measurements failed to show a significant correlation with outcome. Consistent with the advantages of intracochlear EABR over extracochlear EABR, this study demonstrates that intracochlear EABR has prognostic significance in predicting long-term outcomes in patients with narrow IAC. Intracochlear EABR measured either intraoperatively or in the early postoperative period may play an important role in deciding whether to continue with auditory rehabilitation using a cochlear implant or to switch to an auditory brainstem implant so as not to miss the optimal timing for language development.

Superselective intra-arterial chemotherapy in the primary management of advanced intra-ocular retinoblastoma: first 4-year experience from a single institution in Turkey.

PubMed

Tuncer, Samuray; Sencer, Serra; Kebudi, Rejin; Tanyıldız, Burak; Cebeci, Zafer; Aydın, Kubilay

2016-11-01

To report our 4-year experience in Turkey, with advanced intra-ocular retinoblastoma managed primarily with intra-arterial chemotherapy (IAC). From October 2011 to September 2015, 26 group D eyes of 24 treatment-naïve retinoblastoma patients managed primarily with IAC were evaluated in this prospective study. Of 76 procedures, ophthalmic artery cannulation failed in two patients with unilateral involvement. In the remaining 22 patients (24 eyes), the mean age at diagnosis was 18 months (range, 6-55 months). Each eye received a mean of 3 IAC sessions/eye (range, 2-5 sessions). After a median follow-up of 29 months (range, 6-55 months), complete regression of the main tumour was achieved in 23 of 24 eyes. One eye with partial regression required enucleation due to ciliary body involvement by the tumour. Overall, 16 eyes (66.6%) were salvaged with primary IAC with or without additional local treatments, and eight (33.3%) required enucleation. The main IAC-related periocular complications included transient eyelid oedema (n = 13), ptosis (n = 6) and forehead hyperpigmentation (n = 3), each resolving in 2 weeks to 4 months. Intra-ocular complications included chorioretinal atrophy (n = 9), newly noted retinal detachment (n = 5) and vitreous haemorrhage (n = 1). Kaplan-Meier eye estimates of enucleation-free survival rates were 83.3% (95% CI, 68.4-98.1%), 69.1% (95% CI, 49.8-88.3%) and 62.9 (95% CI, 41.9-83.8%) at 6 months, 1 and 2 years, respectively, and stable thereafter. Our first 4-year experience in Turkey showed that enucleation or external-beam radiotherapy could be avoided in two-thirds of eyes with advanced intra-ocular retinoblastoma managed primarily with IAC. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

75 FR 72956 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Clean Air Interstate Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... ``biomass'' was added so that cogeneration units could exclude biomass energy input in efficiency... the cogeneration unit definition to exclude energy input from biomass. At 326 IAC 24-1-2 (8), 326 IAC... ``Biomass'' in Reference to ``Cogeneration Unit'' H. The State's Complete CAIR Regulations I. NO X Reduction...

IAC Standardized Reporting of Breast Fine-Needle Aspiration Biopsy Cytology.

PubMed

Field, Andrew S; Schmitt, Fernando; Vielh, Philippe

2017-01-01

There have been many changes in the roles of fine-needle aspiration biopsy (FNAB) and core needle biopsy (CNB) in the diagnostic workup of breast lesions in routine breast clinics and in mammographic breast screening programs, as well as changes in the management algorithms utilized and the treatments available, since the NCI consensus on breast FNAB cytology in 1996. A standardized approach will improve training and performance of FNAB and smear-making techniques, and structured reporting will improve the quality and reproducibility of reports across departments, cities and countries providing a basis for quality assurance measures and improving patient care and facilitating research. Linking cytology reports to management algorithms will increase the clinicians' use of FNAB cytology and where appropriate CNB, and enhance the use of ancillary tests for prognostic testing. The IAC recognizes that the local medical infrastructure and resources for breast imaging, biopsy and treatment will influence the diagnostic workup and management of breast disease, but best practice guidelines should be established and modified as required. © 2016 S. Karger AG, Basel.

The Scientific and Engineering Student Internship (SESI) Program at NASA's GSFC

NASA Astrophysics Data System (ADS)

Bruhweiler, F.; Verner, E.; Rabin, D. M.

2011-12-01

Through our Scientific and Engineering Student Internship (SESI) program we have provided exceptional research opportunities for undergraduate and graduate students in one of the world's premier research centers dedicated to the Sun and its heliosphere, the Heliophysics Science Division at NASA/Goddard Space Flight Center. NASA/GSFC and the NSF/REU program have funded this activity jointly. These opportunities combine the advantages of the stimulating, multi-disciplinary, environment of a NASA laboratory with the guidance provided by researchers who are, in addition, committed to education and the encouragement of women, under-represented minorities, and students with disabilities. Opportunities also exist for non-U.S. citizens as well. Moreover, the surrounding Washington, DC area provides a variety of social and educational activities for our participating students. Our 19 years of experience has served as an effective catalyst, enabling us to establish a formal program for students interested in Solar and Space Physics at NASA and to develop more NASA-funded opportunities for students, in addition to those funded by NSF/REU awards. This has allowed us to present a combined NSF/REU and NASA-funded program for undergraduates at NASA/GSFC. This synergistic program exposes our student interns to a very wide range of projects and ideas, normally unavailable in other programs. We have had roughly 300 students (about 1/2 being supported by NSF) actively participate in over 200 different research opportunities. These research projects have spanned the spectrum, ranging from theoretical modeling associated with space weather, developing instrumentation for space missions, analysis of spacecraft data, including 'hands-on' experience with sounding rockets and working in the clean environs of GSFC's Detector Development Laboratory. Although SESI is largely a summer program, a number of students, often through other funding sources, continue their research projects during subsequent summers or in the academic year. Further information can be obtained at http://iacs.cua.edu and http://sesi.gsfc.nasa.gov/ This program is funded through NSF grant AGS-1062729 and NASA/GSFC grant NNX11AJ04G.

Correlation between auditory function and internal auditory canal pressure in patients with vestibular schwannomas.

PubMed

Lapsiwala, Samir B; Pyle, G Mark; Kaemmerle, Ann W; Sasse, Frank J; Badie, Behnam

2002-05-01

Hearing loss is the most common presenting symptom in patients who harbor a vestibular schwannoma (VS). Although mechanical injury to the cochlear nerve and vascular compromise of the auditory apparatus have been proposed, the exact mechanism of this hearing loss remains unclear. To test whether pressure on the cochlear nerve from tumor growth in the internal auditory canal (IAC) is responsible for this clinical finding, the authors prospectively evaluated intracanalicular pressure (ICaP) in patients with VS and correlated this with preoperative brainstem response. In 40 consecutive patients undergoing a retrosigmoid-transmeatal approach for tumor excision, ICaP was measured by inserting a pressure microsensor into the IAC before any tumor manipulation. Pressure recordings were correlated with tumor size and preoperative auditory evoked potential (AEP) recordings. The ICaP, which varied widely among patients (range 0-45 mm Hg), was significantly elevated in most patients (median 16 mm Hg). Although these pressure measurements directly correlated to the extension of tumor into the IAC (p = 0.001), they did not correlate to total tumor size (p = 0.2). In 20 patients in whom baseline AEP recordings were available, the ICaP directly correlated to wave V latency (p = 0.0001), suggesting that pressure from tumor growth in the IAC may be responsible for hearing loss in these patients. Tumor growth into the IAC results in elevation of ICaP and may play a role in hearing loss in patients with VS. The relevance of these findings to the surgical treatment of these tumors is discussed.

Hearing loss and enlarged internal auditory canal in children.

PubMed

Santos, Saturnino; Domínguez, M Jesús; Cervera, Javier; Suárez, Alicia; Bueno, Antonio; Bartolomé, Margarita; López, Rafael

2014-01-01

Among the temporal bone abnormalities that can be found in the etiological study of paediatric sensorineural hearing loss (SNHL) by imaging techniques, those related to the internal auditory canal (IAC) are the least frequent. The most prevalent of these abnormalities that is associated with SNHL is stenotic IAC due to its association with cochlear nerve deficiencies. Less frequent and less concomitant with SNHL is the finding of an enlarged IAC (>8mm). Retrospective and descriptive review of clinical associations, imaging, audiological patterns and treatment of 9 children with hearing loss and enlarged IAC in the period 1999 to 2012. Two groups of patients are described. The first, without association with vestibulocochlear dysplasias, consisted of: 2 patients with SNHL without other temporal bone or systemic abnormalities, one with bilateral mixed HL from chromosome 18q deletion, one with a genetic X-linked DFN3 hearing loss, one with unilateral hearing loss in neurofibromatosis type 2 with bilateral acoustic neuroma, and one with unilateral hearing loss with cochlear nerve deficiency. The second group, with association with vestibulocochlear dysplasias, was comprised of: one patient with moderate bilateral mixed hearing loss in branchio-oto-renal syndrome, one with profound unilateral SNHL with recurrent meningitis, and another with profound bilateral SNHL with congenital hypothyroidism. The presence of an enlarged IAC in children can be found in different clinical and audiological settings with relevancies that can range from life-threatening situations, such as recurrent meningitis, to isolated hearing loss with no other associations. Copyright © 2013 Elsevier España, S.L. All rights reserved.

Monoclonal IgA Antibodies for Aflatoxin Immunoassays

PubMed Central

Ertekin, Özlem; Pirinçci, Şerife Şeyda; Öztürk, Selma

2016-01-01

Antibody based techniques are widely used for the detection of aflatoxins which are potent toxins with a high rate of occurrence in many crops. We developed a murine monoclonal antibody of immunoglobulin A (IgA) isotype with a strong binding affinity to aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), aflatoxin G2 (AFG2) and aflatoxin M1 (AFM1). The antibody was effectively used in immunoaffinity column (IAC) and ELISA kit development. The performance of the IACs was compatible with AOAC performance standards for affinity columns (Test Method: AOAC 991.31). The total binding capacity of the IACs containing our antibody was 111 ng, 70 ng, 114 ng and 73 ng for AFB1, AFB2, and AFG1 andAFG2, respectively. Furthermore, the recovery rates of 5 ng of each AF derivative loaded to the IACs were determined as 104.9%, 82.4%, 85.5% and 70.7% for AFB1, AFB2, AFG1 and AFG2, respectively. As for the ELISA kit developed using non-oriented, purified IgA antibody, we observed a detection range of 2–50 µg/L with 40 min total test time. The monoclonal antibody developed in this research is hitherto the first presentation of quadruple antigen binding IgA monoclonal antibodies in mycotoxin analysis and also the first study of their utilization in ELISA and IACs. IgA antibodies are valuable alternatives for immunoassay development, in terms of both sensitivity and ease of preparation, since they do not require any orientation effort. PMID:27187470

Liver metastases from melanoma: hepatic intra-arterial chemotherapy. A retrospective study.

PubMed

Farolfi, A; Ridolfi, L; Guidoboni, M; Milandri, C; Calzolari, F; Scarpi, E; Amadori, D; Ridolfi, R

2011-10-01

The liver is the primary site of metastases in most uveal melanoma patients. We retrospectively investigated intraarterial chemotherapy (IAC) as treatment for patients with hepatic melanoma metastases.Twenty-three patients (18 with uveal melanoma) received fotemustine (14 patients, 61.9%) or carboplatin (9 patients, 31.1%) via hepatic IAC delivery. The catheter was introduced through percutaneous access to the femoral artery with drugs delivered directly to the hepatic artery, and was removed at the end of each treatment cycle. A total of 3 cycles was planned, repeated every 21 days. However, patients with a clinical response could receive more than 3 cycles, provided that the toxic effects were acceptable.IAC was well tolerated and no catheter-related complications or grade 4 toxicities were reported. Considering only uveal melanoma patients, the overall response rate and disease control rate was 16.7% and 38.9%, respectively. Median time to progression was 6.2 months (95% CI 3.7-10.5) and median overall survival was 21 months (95% CI 8-39).IAC is well tolerated and is a valid choice for patients with a poor prognosis since median survival rates are among the longest reported.

GSFC Supplier Surveillance

NASA Technical Reports Server (NTRS)

Kelly, Michael P.

2011-01-01

Topics covered include: Develop Program/Project Quality Assurance Surveillance Plans The work activities performed by the developer and/or his suppliers are subject to evaluation and audit by government-designated representatives. CSO supports project by selecting on-site supplier representative s by one of several methods: (1) a Defense Contract Management Agency (DCMA) person via a Letter Of Delegation (LOD), (2) an independent assurance contractor (IAC) via a contract Audits, Assessments, and Assurance (A3) Contract Code 300 Mission Assurance Support Contract (MASC)

Diallel analysis of corn for special use as corn grits: determining the main genetic effects for corn gritting ability.

PubMed

Conrado, T V; Scapim, C A; Bignotto, L S; Pinto, R J B; Freitas, I L J; Amaral, A T; Pinheiro, A C

2014-08-26

Corn grits are used for various purposes such as flakes, snacks, livestock feed, hominy, extruded products, beer, etc. The grit size proportion varies according to the hybrid, and thus, once the use of the grits is linked to the particle size, determining the genetic effects is essential to develop hybrids for any specific use. For this purpose a complete diallel series of crosses, involving eight parents, was performed near Maringá, PR, Brazil. The objective of this study was to evaluate the general (GCA) and specific (SCA) combining abilities of 28 progeny for selection of hybrids for breeding programs and extraction of inbred lines for hybrid development. The response variables, such as plant height, ear insertion height, crop stand, grain yield, and grits, small grits and bran production, were gauged and appraised for each of the 28 progeny. The trait effects and GCA were significant for all response variables, while for SCA, only grain yield and crop stand showed significance (P < 0.05), according to Griffing (1955) analysis. A significant weak negative partial correlation was found between grain yield and grits conversion. In relation to the hybrid selection for breeding programs, the parent IAC Nelore was highly recommended for recurrent selection and the hybrids IPR 119 x HT 392 and IAC Nelore x HD 332 for the extraction of pure lines for hybrid development.

Quantitative real-time PCR method with internal amplification control to quantify cyclopiazonic acid producing molds in foods.

PubMed

Rodríguez, Alicia; Werning, María L; Rodríguez, Mar; Bermúdez, Elena; Córdoba, Juan J

2012-12-01

A quantitative TaqMan real-time PCR (qPCR) method that includes an internal amplification control (IAC) to quantify cyclopiazonic acid (CPA)-producing molds in foods has been developed. A specific primer pair (dmaTF/dmaTR) and a TaqMan probe (dmaTp) were designed on the basis of dmaT gene which encodes the enzyme dimethylallyl tryptophan synthase involved in the biosynthesis of CPA. The IAC consisted of a 105 bp chimeric DNA fragment containing a region of the hly gene of Listeria monocytogenes. Thirty-two mold reference strains representing CPA producers and non-producers of different mold species were used in this study. All strains were tested for CPA production by high-performance liquid chromatography-mass spectrometry (HPLC-MS). The functionality of the designed qPCR method was demonstrated by the high linear relationship of the standard curves relating to the dmaT gene copy numbers and the Ct values obtained from the different CPA producers tested. The ability of the qPCR protocol to quantify CPA-producing molds was evaluated in different artificially inoculated foods. A good linear correlation was obtained over the range 1-4 log cfu/g in the different food matrices. The detection limit in all inoculated foods ranged from 1 to 2 log cfu/g. This qPCR protocol including an IAC showed good efficiency to quantify CPA-producing molds in naturally contaminated foods avoiding false negative results. This method could be used to monitor the CPA producers in the HACCP programs to prevent the risk of CPA formation throughout the food chain. Copyright © 2012 Elsevier Ltd. All rights reserved.

MASTER-IAC: bright PSN in PGC1030654

NASA Astrophysics Data System (ADS)

Balanutsa, P.; Lipunov, V.; Lopez, R. Rebolo; Serra-Ricart, M.; Gorbovskoy, E.; Kornilov, V.; Tiurina, N.; Kuznetsov, A.; Gress, O.; Shumkov, V.; Vetrov, K.; Vladimirov, V.; Gorbunov, I.; Zimnukhov, D.; Vlasenko, D.; Kuvshinov, D.

2018-01-01

MASTER-IAC auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered OT source at (RA, Dec) = 14h 21m 17.5s -06d 37m 36.1s on 2018-01-26.1918UT . The OT unfiltered magnitude is (mlim=19.8) This PSN is in 7.8" from PGC 1030654 (Btc=15.7, also GALEX source).

Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinoma

PubMed Central

Lertpiriyapong, Kvin; Handt, Laurence; Feng, Yan; Mitchell, Thomas W.; Lodge, Kenneth E.; Shen, Zeli; Dewhirst, Floyd E.; Muthupalani, Sureshkumar

2014-01-01

Considerable progress has been made in understanding the roles of Helicobacter pylori in inflammation and gastric cancer; however, far less is known about the roles of enterohepatic Helicobacter species (EHS) in carcinogenesis and their zoonotic or pathogenic potential. We determined the prevalence of EHS infection in a cohort of geriatric rhesus monkeys in which intestinal adenocarcinoma (IAC) is common and investigated the association between EHS infection and IAC. The cohort consisted of 36 animals, 14 of which (age 26–35 years) had IAC. Of the 36 rhesus, 35 (97 %) were positive for EHS using PCR or bacterial isolation from faeces, colonic or tumour tissues. Only a single rhesus, which had IAC, was negative for EHS by all detection methods. The EHS identified by 16S rRNA sequencing in this study were from three Helicobacter taxa: Helicobacter macacae (previously rhesus monkey taxon 1), Helicobacter sp. rhesus monkey taxon 2, previously described from strain MIT 99-5507, and Helicobacter sp. rhesus monkey taxon 4, related to Helicobacter fennelliae. Thirteen of 14 monkeys with IAC were positive for either H. macacae (7/13, 54 %), EHS rhesus monkey taxon 4 (4/13, 31 %) or a mixture of the two EHS (2/13, 15 %). These results indicate that EHS are prevalent among aged rhesus macaques with IAC. Using Helicobacter genus-specific florescent in situ hybridization, EHS were detected on the surface of colonic epithelia of infected monkeys. All Helicobacter isolates, including H. macacae, effectively adhered to, invaded, and significantly induced proinflammatory genes, including IL-8, IL-6, TNF-α and iNOS, while downregulating genes involved in the function of inflammasomes, particularly IL-1β, CASPASE-1, NRLP3, NLRP6 and NLRC4 in the human colonic T84 cell line (P<0.0001). These results suggest that EHS may represent an aetiological agent mediating diarrhoea, chronic inflammation, and possibly intestinal cancer in non-human primates, and may play a role in similar disease syndromes in humans. Downregulation of inflammasome function may represent an EHS strategy for long-term persistence in the host and play a role in inducing pathological changes in the host’s lower bowel. PMID:24696515

Reduction of severe visual loss and complications following intra-arterial chemotherapy (IAC) for refractory retinoblastoma.

PubMed

Reddy, M Ashwin; Naeem, Zishan; Duncan, Catriona; Robertson, Fergus; Herod, Jane; Rennie, Adam; Liasis, Alki; Thompson, Dorothy Ann; Sagoo, Mandeep

2017-12-01

Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres. Retrospective cohort study of patients with retinoblastoma from 2013 to 2015 who had a healthy foveola and relapsed following systemic chemotherapy. All required IAC. The correlation of complications with doses of melphalan +/- topotecan used and putative catheterisation complications was assessed. Ocular complications were determined using vision, macular (including pattern visual evoked potentials (PVEPs)), retinal electroretinograms (ERGs) and ocular motility functions. Efficacy (tumour control) was also assessed. All eyes had age appropriate doses of melphalan with five having additional doses of topotecan. Severe physiological reactions requiring adrenaline were seen in six patients during the catheterisation procedure. Difficulty was documented in accessing the ophthalmic artery in 7/27 catheterisations. The median/mean number of courses of chemotherapy was three. No child had severe visual loss as assessed by age appropriate tests (median follow-up 20.9 months, range 3.7-35.2 months). One child had nasal choroidal ischaemia and a sixth nerve palsy. Post-IAC PVEPs were performed in eight and reported as normal. All post-IAC ERGs were normal apart from one (total dose 20 mg melphalan 0.8 mg topotecan). Tumour control was achieved in six of nine cases. The proportion of visual and ocular motility complications may be reduced by providing age-adjusted doses of melphalan. Dose rather than complications from catheterisation is the most important risk factor for ocular injury. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Intracanal temperature changes during bone preparations close to and penetrating the inferior alveolar canal: Drills versus piezosurgery.

PubMed

Szalma, József; Vajta, László; Lempel, Edina; Tóth, Ákos; Jeges, Sára; Olasz, Lajos

2017-10-01

The aim of this in vitro study was to investigate temperature increases in the inferior alveolar canal (IAC), when different bone preparation methods approximate and penetrate the IAC. In pig mandible, buccal bone removals were performed until the neurovascular bundle became visible. Temperatures were registered with thermocouple probes and with infrared thermometer. Preparations were performed with diamond drills (DD), tungsten carbide drills (TCD), piezoelectric diamond sphere (PT_D) and saw (PT_S) tips, and a combined preparation method was also performed whereby the superficial three-fourths of the bone was removed with TCD and the deepest one-fourth of the bone with PT_D (TCD + PT_D_7 °C) or PT_S (TCD + PT_S_7 °C), using cooled irrigation (7 °C). Preparations using room temperature irrigation caused significantly less heat on the bone surface than in the IAC. Piezosurgery in the IAC produced significantly higher temperatures (>13 °C) than the drills (<4 °C). Heat productions of the piezoelectric tips were reduced significantly by applying the combined bone removal methods. The speed of PT_S and TCD + PT_S_7 °C were comparable to the speed of TCD, whereas TCD + PT_D_7 °C was found to be significantly slower. The speed of piezosurgery is comparable to that of the drills; however, it produces the highest, potentially nerve-harming temperatures. To eliminate the heat consequences during piezosurgery in the IAC, the use of cooled irrigation at 7 °C and predrilling is recommended. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Young-Hoon; Department of Neurosurgery, Seoul National University College of Medicine, Seoul; Kim, Dong Gyu, E-mail: gknife@plaza.snu.ac.kr

2012-11-01

Purpose: This study was performed to assess the radiosurgical results of meningiomas extending into the internal acoustic canal (para-IAC meningiomas), with a particular focus on the effect of radiation dose to the cochlea on hearing outcome. Methods and Materials: A total of 50 patients who underwent radiosurgery for para-IAC meningiomas between 1998 and 2009, which were followed for 2 years, were enrolled. The mean age was 55.8 years (range, 15-75). The mean tumor volume was 6.1 cm{sup 3} (range, 1.0-19.0), the mean tumor length in the IAC was 6.9 mm (range, 1.3-13.3), and the mean prescribed marginal dose was 13.1more » Gy (range, 10-15) at an isodose line of 50%. The mean follow-up duration was 46 months (range, 24-122). Results: Eight (16.0%) patients had nonserviceable hearing at the time of surgery. At the last follow-up, the tumor control rate was 94%; unchanged in 17 patients, decreased in 30 patients, and increased in 3 patients. Among 42 patients with serviceable hearing at the time of radiosurgery, it was preserved in 41 (97.6%) patients at the last follow-up. The maximal and mean radiation doses to the cochleae of these 41 patients were 5.8 Gy {+-} 0.3 (range, 3.1-11.5) and 4.3 Gy {+-} 0.2 (range, 2.2-7.5), respectively. The maximal dose to the cochlea of the patient who lost hearing after radiosurgery was 4.7 Gy. Conclusions: The radiation dose to the cochlea may have the minimal toxic effect on the hearing outcome in patients who undergo radiosurgery for para-IAC meningiomas.« less

Cochlear implantation using a custom guide catheter in fourteen patients with incomplete partition type III.

PubMed

Tian, Hao; Wang, Line; Gao, Fenqi; Liang, Wenqi; Peng, Kevin A

2018-05-22

Incomplete partition type III (IP-III), also termed X-linked deafness with stapes gusher, is a heterogeneous condition that predominantly affects males; however, females demonstrating the phenotype also exist. The absence of a bony partition between the fundus of the internal auditory canal (IAC) and cochlea predisposes these patients to cerebrospinal fluid leak or electrode passage into the IAC when performing cochlear implantation. We describe a surgeon-fabricated guide catheter, made intraoperatively from a 16-gauge intravenous catheter, that helps avoid electrode passage into the IAC during CI for patients with IP-III. Acceptable cochlear implant outcomes were attainable in IP-III patients, but these patients scored worse than matched CI patients with normal inner ear structures. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Riemann solvers and Alfven waves in black hole magnetospheres

NASA Astrophysics Data System (ADS)

Punsly, Brian; Balsara, Dinshaw; Kim, Jinho; Garain, Sudip

2016-09-01

In the magnetosphere of a rotating black hole, an inner Alfven critical surface (IACS) must be crossed by inflowing plasma. Inside the IACS, Alfven waves are inward directed toward the black hole. The majority of the proper volume of the active region of spacetime (the ergosphere) is inside of the IACS. The charge and the totally transverse momentum flux (the momentum flux transverse to both the wave normal and the unperturbed magnetic field) are both determined exclusively by the Alfven polarization. Thus, it is important for numerical simulations of black hole magnetospheres to minimize the dissipation of Alfven waves. Elements of the dissipated wave emerge in adjacent cells regardless of the IACS, there is no mechanism to prevent Alfvenic information from crossing outward. Thus, numerical dissipation can affect how simulated magnetospheres attain the substantial Goldreich-Julian charge density associated with the rotating magnetic field. In order to help minimize dissipation of Alfven waves in relativistic numerical simulations we have formulated a one-dimensional Riemann solver, called HLLI, which incorporates the Alfven discontinuity and the contact discontinuity. We have also formulated a multidimensional Riemann solver, called MuSIC, that enables low dissipation propagation of Alfven waves in multiple dimensions. The importance of higher order schemes in lowering the numerical dissipation of Alfven waves is also catalogued.

Immunoaffinity column as clean-up tool for determination of trace amounts of microcystins in tap water.

PubMed

Tsutsumi, T; Nagata, S; Hasegawa, A; Ueno, Y

2000-07-01

Trace amounts of microcystins (MCs) in drinking water should be monitored because of their potential hazard for human health as an environmental tumor promoter. We describe here a new clean-up tool with immunoaffinity column (IAC) for determination of trace amounts of MCs (from pg to microg/litre) in tap water. The water samples were concentrated with IAC clean-up and MCs levels were determined by HPLC with UV detection or enzyme-linked immunosorbent assay (ELISA). In the combination with HPLC analysis, mean recovery of microcystin-LR (MCLR),-RR and-YR spiked to tap water were 91.8%, 77.3% and 86.4%, respectively, in the range 2.5-100 microg/litre. The chromatogram of MCs-spiked tap water sample cleaned up with IAC showed effective elimination of the impurities compared to that with octadecyl silanized cartridge, which had been cleaned up with a conventional method. Also, in the combination with highly sensitive ELISA, mean recovery of MCLR spiked to tap water was 80% in the range 0.1-1000 ng/litre. The combined methods developed here can detect pg to microg/litre of MCs in tap water. The overall results indicated that IAC will be suitable as a clean-up tool for trace amounts of MCs in tap water.

Antibiosis in Soybean Genotypes and the Resistance Levels to Spodoptera eridania (Cramer) (Lepidoptera: Noctuidae).

PubMed

Souza, B H S; Silva, A G; Janini, J C; Boica Júnior, A L

2014-12-01

The southern armyworm (SAW) Spodoptera eridania (Cramer) is one of the most common armyworm species defoliating soybeans. Preliminary screening trials have indicated that some soybean genotypes exhibit resistance to SAW. Therefore, in this study, we evaluated the development of SAW larvae fed on ten soybean genotypes in order to identify genotypes with antibiosis-type resistance. Neonate SAW larvae were daily fed with young leaves collected from plants at the vegetative growth stages V4-V5. Larval development and survival were recorded. Genotypes PI 227687 and PI 227682 delayed larval, pupal, and larva-adult development and yielded larvae with the lowest weight and survival and pupae with the lowest weight. Genotypes IAC 100 and DM 339 also negatively affected larval and pupal development and larval survival but at a lower level. Based on our results, the soybean lines PI 227687 and PI 227682 could be used as sources of genes for soybean breeding programs aiming to develop high yield, SAW-resistant cultivars. Moreover, further trials must be carried out under field conditions to validate if the commercial cultivars IAC 100 and DM 339, which expressed moderate levels of antibiosis-type resistance in the laboratory, are effective in suppressing SAW larvae populations.

VizieR Online Data Catalog: MASCARA-2 b (HD185603) light curves and spectra (Talens+, 2018)

NASA Astrophysics Data System (ADS)

Talens, G. J. J.; Justesen, A. B.; Albrecht, S.; McCormac, J.; van Eylen, V.; Otten, G. P. P. L.; Murgas, F.; Palle, E.; Pollacco, D.; Stuik, R.; Spronck, J. F. P.; Lesage, A.-L.; Grundahl, F.; Fredslund Andersen, M.; Antoci, V.; Snellen, I. A. G.

2018-02-01

Photometric time-series and radial velocities obtained for MASCARA-2 using the MASCARA, NITES, IAC80 and SONG telescopes. The MASCARA photometry covers the period from February 2015 to December 2016 and utilizes no filter. The NITES and IAC80 photometry was obtained during the night of 4 June 2017 utilizing the R filter. The SONG RVs cover the period from May-June 2017. (26 data files).

Impact of Frozen Storage on the Anthocyanin and Polyphenol Content of American Elderberry Fruit Juice

PubMed Central

Johnson, Mitch C.; Thomas, Andrew L.; Greenlief, C. Michael

2015-01-01

The effects of frozen storage on the anthocyanin and polyphenol content of elderberry fruit juice are investigated. Juice from three genotypes of American elderberry (Adams II, Bob Gordon, and Wyldewood) was screened for total phenolic (TP) and total monomeric anthocyanin (TMA) content with spectrophotometric methods. The individual anthocyanin content (IAC) of the juice was tested by coupling solid phase extraction with ultra-performance liquid chromatography/tandem mass spectrometry. Juice samples were tested initially upon harvest, then again after 3, 6, and 9 months of frozen storage. Juice from the three different genotypes had significantly different TP, TMA, and IAC profiles initially (p<0.05). The TP,, TMA, and IAC content of the juice from different genotypes were significantly affected (p<0.05) by the frozen storage time, suggesting that both genotype and length of frozen storage time can affect the anthocyanin content of elderberry fruit juice. PMID:26028422

A system of IAC neural networks as the basis for self-organization in a sociological dynamical system simulation.

PubMed

Duong, D V; Reilly, K D

1995-10-01

This sociological simulation uses the ideas of semiotics and symbolic interactionism to demonstrate how an appropriately developed associative memory in the minds of individuals on the microlevel can self-organize into macrolevel dissipative structures of societies such as racial cultural/economic classes, status symbols and fads. The associative memory used is based on an extension of the IAC neural network (the Interactive Activation and Competition network). Several IAC networks act together to form a society by virtue of their human-like properties of intuition and creativity. These properties give them the ability to create and understand signs, which lead to the macrolevel structures of society. This system is implemented in hierarchical object oriented container classes which facilitate change in deep structure. Graphs of general trends and an historical account of a simulation run of this dynamical system are presented.

Genetic divergence in the common bean (Phaseolus vulgaris L.) in the Cerrado-Pantanal ecotone.

PubMed

da Silva, F A; Corrêa, A M; Teodoro, P E; Lopes, K V; Corrêa, C C G

2017-03-30

Evaluating genetic diversity among genotypes is important for providing parameters for the identification of superior genotypes, because the choice of parents that form segregating populations is crucial. Our objectives were to i) evaluate agronomic performance; ii) compare clustering methods; iii) ascertain the relative contributions of the variables evaluated; and iv) identify the most promising hybrids to produce superior segregating populations. The trial was conducted in 2015 at the State University of Mato Grosso do Sul, Brazil. We used a randomized block design with three replications, and recorded the days to emergence, days to flowering, days to maturity, plant height, number of branches, number of pods, number of seeds per pod, weight of 100 grains, and productivity. The genetic diversity of the genotypes was determined by cluster analysis using two dissimilarity measures: the Euclidean distance and the standardized mean Mahalanobis distance using the Ward hierarchical method. The genotypes 'CNFC 10762', 'IAC Dawn', and 'BRS Style' had the highest grain yields, and clusters that were based on the Euclidean distance differed from those based on the Mahalanobis distance, the second being more precise. The yield grain character has greater relevance to the dispute. Hybrids with a high heterotic effect can be obtained by crossing 'IAC Alvorada' with 'CNFC 10762', 'IAC Alvorada' with 'CNFC 10764', and 'BRS Style' with 'IAC Alvorada'.

PREFACE: 15th International Conference on Strangeness in Quark Matter (SQM2015)

NASA Astrophysics Data System (ADS)

Alvarez-Castillo, D.; Blaschke, D.; Kekelidze, V.; Matveev, V.; Sorin, A.

2016-01-01

The 15th International Conference Strangeness in Quark Matter (SQM) took place at the Veksler and Baldin Laboratory of High Energy Physics (VBLHEP) of the Joint Institute for Nuclear Research (JINR) in Dubna in the period July 6 -11, with a record participation of 244 people from 31 countries! The previous meeting of the series in Birmingham 2013 had collected 158 physicists from 25 countries [J. Phys. Conf. Ser. 509, 011001 (2014)]. At SQM-2015, there was also a record participation of young scientist; every 4th conference attendee did not yet hold a PhD degree! There was a special program of 4 general lectures, a devoted session of parallel talks for Young Talents and the Helmholtz International Summer School (HISS) with 16 lecturers on the topics regarding Dense Matter (29.06.-11.07.) as a satellite event at the Bogoliubov Laboratory of Theoretical Physics (BLTP) and at VBLHEP. Another satellite event was the Round TableWorkshop on Physics at NICA, jointly organized by JINR and the Republic of South Africa on July 5, 2015. The selection of Dubna as the place for SQM-2015 conference by the International Advisory Committee (IAC) demonstrates the broad interest of the community in the progress of the Russian Megascience Project on the Nuclotron-based Ion Collider Facility (NICA) hosted at JINR Dubna. In a few years from now the experiments planned at NICA will produce data that provide new information of unprecedented accuracy which will help to answer some of the key questions which are topical at this conference. The SQM-2015 conference had an ambitious scientific program with 38 plenary talks, 97 parallel talks in 7 topical directions and 39 posters reporting the state of the research and the future directions in the fields of strangeness, heavy avors and bulk physics, suggested by the IAC to be the subtitle of the conference from 2016 onwards. Most of the contributions are represented in these Proceedings which we recommend to the community! We gratefully acknowledge support from the JINR Dubna, the Russian Foundation for Basic Research, the Bundesministerium für Bildung und Forschung via the Heisenberg-Landau program, the Ministerstwo Nauki i Szkolnistwa Wyższego via the Bogoliubov-Infeld program, the LOEWE program via HIC for FAIR, the Helmholtz Association with their centres DESY, FZ Jülich, GSI Darmstadt, HZ Dresden-Rossendorf, Karlsruhe Institute of Technology and the Helmholtz Institutes in Mainz and Jena via the HISS programme. We thank the IAC for their help and advice in planning the conference, and we are grateful to the members of the Local Organisation Committee for their help in during the conference as well as to Niels-Uwe Bastian, Alexandra Friesen, Mark Alexander Kaltenborn and Irina Pirozhenko for their assistance in preparing these Proceedings.

ESO-NTT Large Program spectroscopic classification of SNhunt 121

NASA Astrophysics Data System (ADS)

Benitez-Herrera, S.; Taubenberger, S.; Valenti, S.; Benetti, S.; Pastorello, A.

2012-04-01

We report, on behalf of a larger collaboration, that a spectrogram of SNhunt121 (PSN J06424255-2726498), obtained on Apr. 14.02 UT with the European Southern Observatory's New Technology Telescope (+ EFOSC2; range 365-930 nm; resolution 1.8 nm), shows it to be a peculiar type-Ic supernova. The best matches to this spectrum found by GELATO (Harutyunyan et al. 2008, A.Ap. 488, 383; available at https://gelato.tng.iac.es/login.cgi) suggest that SNhunt121 is a few weeks after maximum light.

Characterization of the Origin of DNA Replication of the Coxiella burnetii Chromosome

DTIC Science & Technology

1990-01-26

chromosomal DNAs (FIG. IB): the 19.4-kb EcoR I fragment of Salmonella typhimurium DNA (lane 4),9 the 17.5-kb Sal I fragment of Enterobacter aerogenes ...IacZYA-argF) U 1694680d IacZAM15 Salmonella typhimurium Wild type WVUd Kiebsiella pneumoniae Wild type WVUd Enterobacter aero genes Wild type WVUd... aerogenes and K. pneumoniae were digested with appropriate restriction enzymes. The restriction fragments were separated on a 0.9% agarose gel, transferred to

Adaptive capacity of fishing communities at marine protected areas: a case study from the Colombian Pacific.

PubMed

Moreno-Sánchez, Rocío del Pilar; Maldonado, Jorge Higinio

2013-12-01

Departing from a theoretical methodology, we estimate empirically an index of adaptive capacity (IAC) of a fishing community to the establishment of marine protected areas (MPAs). We carried out household surveys, designed to obtain information for indicators and sub-indicators, and calculated the IAC. Moreover, we performed a sensitivity analysis to check for robustness of the results. Our findings show that, despite being located between two MPAs, the fishing community of Bazán in the Colombian Pacific is highly vulnerable and that the socioeconomic dimension of the IAC constitutes the most binding dimension for building adaptive capacity. Bazán is characterized by extreme poverty, high dependence on resources, and lack of basic public infrastructure. Notwithstanding, social capital and local awareness about ecological conditions may act as enhancers of adaptive capacity. The establishment of MPAs should consider the development of strategies to confer adaptive capacity to local communities highly dependent on resource extraction.

An Assessment of the USAFE School Board Test Program

DTIC Science & Technology

2002-07-01

2000. USAFE Strategic Plan on Dependent Education, Headquarters, USAFE, October 1998. Vajont ES, http://www.vajo-es.eu.odedodea.edu/ Vogelweh ES...Pordenone ES K–6 109 2/2/0 Vajont ES K–6 157 2/2/0 Aviano AB 4 1,365 11/11/1 4/4/1 10/0 Incirlik ES K–6 475 3/3/0 Incirlik HS 7–12 217...Aviano) K–6 109 AF SB VAJONT ES (Aviano) K–6 157 AVIANO ES K–6 629 AVIANO HS 7–12 470 VICENZA ES K–6 480 A IAC VICENZA HS 7–12 251

A New Experimental Design for Bacterial Microleakage Investigation at the Implant-Abutment Interface: An In Vitro Study.

PubMed

Zipprich, Holger; Miatke, Sven; Hmaidouch, Rim; Lauer, Hans-Christoph

2016-01-01

This study aimed to test bacterial microleakage at the implant-abutment interface (IAI) before and after dynamic loading using a new chewing simulation. Fourteen implant systems (n = 5 samples of each) were divided into two groups: (1) systems with conical implant-abutment connections (IACs), and (2) systems with flat IACs. For collecting samples without abutment disconnection, channels (Ø = 0.3 mm) were drilled into implants perpendicularly to their axes, and stainless-steel cannulas were adhesively glued inside these channels to allow a sterilized rinsing solution to enter the implant interior and to exit with potential contaminants for testing. Implants were embedded in epoxy resin matrices, which were supported by titanium cylinders with lateral openings for inward and outward cannulas. Abutments were tightened and then provided with vertically adjustable, threaded titanium balls, which were cemented using composite cement. Specimens were immersed in a bacterial liquid and after a contact time of 15 minutes, the implant interior was rinsed prior to chewing simulation (0 N ≘ static seal testing). Specimens were exposed to a Frankfurt chewing simulator. Two hundred twenty force cycles per power level (110 in ± X-axis) were applied to simulate a daily masticatory load of 660 chewing cycles (equivalent to 1,200,000 cycles/5 years). The applied load was gradually increased from 0 N to a maximum load of 200 N in 25-N increments. The implant interior was rinsed to obtain samples before each new power level. All samples were tested using fluorescence microscopy; invading microorganisms could be counted and evaluated. No bacterial contamination was detected under static loading conditions in both groups. After loading, bacterial contamination was detected in one sample from one specimen in group 1 and in two samples from two specimens in group 2. Controlled dynamic loading applied in this study simulated a clinical situation and enabled time-dependent analysis regarding the bacterial seal of different implant systems. Conical IACs offer a better bacterial seal compared with flat IACs, which showed increased microleakage after dynamic loading. IAC design plays a crucial role in terms of bacterial colonization. Taking samples of the implant interior without abutment disconnection eliminates an error source.

Image Algebra Matlab language version 2.3 for image processing and compression research

NASA Astrophysics Data System (ADS)

Schmalz, Mark S.; Ritter, Gerhard X.; Hayden, Eric

2010-08-01

Image algebra is a rigorous, concise notation that unifies linear and nonlinear mathematics in the image domain. Image algebra was developed under DARPA and US Air Force sponsorship at University of Florida for over 15 years beginning in 1984. Image algebra has been implemented in a variety of programming languages designed specifically to support the development of image processing and computer vision algorithms and software. The University of Florida has been associated with development of the languages FORTRAN, Ada, Lisp, and C++. The latter implementation involved a class library, iac++, that supported image algebra programming in C++. Since image processing and computer vision are generally performed with operands that are array-based, the Matlab™ programming language is ideal for implementing the common subset of image algebra. Objects include sets and set operations, images and operations on images, as well as templates and image-template convolution operations. This implementation, called Image Algebra Matlab (IAM), has been found to be useful for research in data, image, and video compression, as described herein. Due to the widespread acceptance of the Matlab programming language in the computing community, IAM offers exciting possibilities for supporting a large group of users. The control over an object's computational resources provided to the algorithm designer by Matlab means that IAM programs can employ versatile representations for the operands and operations of the algebra, which are supported by the underlying libraries written in Matlab. In a previous publication, we showed how the functionality of IAC++ could be carried forth into a Matlab implementation, and provided practical details of a prototype implementation called IAM Version 1. In this paper, we further elaborate the purpose and structure of image algebra, then present a maturing implementation of Image Algebra Matlab called IAM Version 2.3, which extends the previous implementation of IAM to include polymorphic operations over different point sets, as well as recursive convolution operations and functional composition. We also show how image algebra and IAM can be employed in image processing and compression research, as well as algorithm development and analysis.

Effects of dairy factory, milk casein content and titratable acidity on coagulation properties in Trentingrana dairy industry.

PubMed

Penasa, Mauro; Toffanin, Valentina; Cologna, Nicola; Cassandro, Martino; De Marchi, Massimo

2016-05-01

The objective of the present study was to investigate the effect of environmental factors, milk casein content and titratable acidity on milk coagulation properties (MCP) of samples routinely collected in the Trento province (northeast Italy) under field conditions. Rennet coagulation time (RCT, min), curd-firming time (k20, min) and curd firmness (a30, mm) were determined by Formagraph on 14 971 samples from 635 herds associated to 17 dairy factories. Besides MCP, fat, protein, and casein percentages, titratable acidity (TA), and somatic cell and bacterial counts were available. A standardised index of milk aptitude to coagulate (IAC) was derived using information of RCT and a30. An analysis of variance was conducted on MCP and IAC using a fixed effects linear model. Approximately 3% of milk samples did not form a curd within the testing time (30 min) and k20 was missing for 26% of milks. The percentage of samples without information on k20 largely differed among dairy factories (1·7-20·9%). Significant differences were estimated between the best and the worst dairy factory for RCT (-2 min), k20 (-1·2 min), a30 (+3·4 mm) and IAC (+2·6 points). Milk casein content and TA were important factors in explaining the variation of MCP and IAC, supporting the central role of these two traits on technological properties. The Trento province is heterogeneous in terms of dairy systems and this could explain the differences among dairy factories.

Panic and comorbid depression and their associations with stress reactivity, interoceptive awareness and interoceptive accuracy of various bioparameters.

PubMed

Limmer, Jan; Kornhuber, Johannes; Martin, Alexandra

2015-10-01

While current theories on perception of interoceptive signals suggest impaired interoceptive processing in psychiatric disorders such as panic disorder or depression, heart-rate (HR) interoceptive accuracy (IAc) of panic patients under resting conditions is superior to that of healthy controls. Thus, in this study, we chose to assess further physiological parameters and comorbid depression in order to get information on how these potentially conflicting findings are linked together. We used a quasi-experimental laboratory design which included multi-parametric physiological data collection of 40 panic subjects and 53 matched no-panic controls, as well as experimental induction of stress and relaxation over a time-course. Stress reactivity, interoceptive awareness (IAw; from the Body Perception Questionnaire (BPQ)) and IAc (as correlation between self-estimation and physiological data) were major outcome variables. Self-estimation of bioparametrical change was measured via numeric rating scales. Panic subjects had stronger HR-reaction and more accurate HR-interoception. Concurrently, though, their IAc of skin conductance level, pulse amplitude and breathing amplitude was significantly lower than that of the control group. Interestingly, comorbid depression was found to be associated with increased IAw but attenuated IAc. Demand characteristics and a categorical approach to panic confine the results. The potentially conflicting findings coalesce, as panic was associated with an increase of the ability to perceive the fear-related parameter and a simultaneous decrease of the ability to perceive other parameters. The superordinate integration of afferent signals might be impaired. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

Image-interactive orientation in the middle cranial fossa approach to the internal auditory canal: an experimental study.

PubMed

Vrionis, F D; Robertson, J H; Foley, K T; Gardner, G

1997-01-01

Approaches through the middle cranial fossa directed at reaching the internal auditory canal (IAC) invariably employ exposure of the geniculate ganglion, the superior semicircular canal (SSC) or the epitympanum. This involves risk to the facial nerve and hearing apparatus. To minimize this risk, we conducted a laboratory study on 9 cadaver temporal bones by using an image-interactive guidance system (StealthStation) to provide topographic orientation in the middle fossa approach. Surface anatomic fiducials such as the umbo of the tympanic membrane, Henle's spine, the root of the zygoma and various sutures were used as fiducials for registration of CT-images of the temporal bone. Accurate localization of the IAC was achieved in every specimen. Mean target localization error varied from 1.20 to 1.38 mm for critical structures in the temporal bone such as the apex of the cochlea, crus commune, ampula of the SSC and facial hiatus. Our results suggest that frameless stereotaxy may be used as an alternative to current methods in localizing the IAC in patients with small vestibular schwannomas or intractable vertigo undergoing middle fossa surgery.

Global partnerships: Expanding the frontiers of space exploration education

NASA Astrophysics Data System (ADS)

MacLeish, Marlene Y.; Akinyede, Joseph O.; Goswami, Nandu; Thomson, William A.

2012-11-01

Globalization is creating an interdependent space-faring world and new opportunities for international partnerships that strengthen space knowledge development and transfer. These opportunities have been codified in the Global Exploration Strategy, which endorses the "inspirational and educational value of space exploration" [1]. Also, during the 2010 Heads of Space Agencies Summit celebrating the International Academy of Astronautics' (IAA) 50th Anniversary, space-faring nations from across the globe issued a collective call in support of robust international partnerships to expand the frontiers of space exploration and generate knowledge for improving life on Earth [2]. Educators play a unique role in this mission, developing strategic partnerships and sharing best educational practices to (1) further global understanding of the benefits of space exploration for life on Earth and (2) prepare the next generation of scientists required for the 21st Century space workforce. Educational Outreach (EO) programs use evidence-based, measurable outcomes strategies and cutting edge information technologies to transfer space-based science, technology, engineering and mathematics (STEM) knowledge to new audiences; create indigenous materials with cultural resonance for emerging space societies; support teacher professional development; and contribute to workforce development initiatives that inspire and prepare new cohorts of students for space exploration careers. The National Space Biomedical Research Institute (NSBRI), the National Aeronautics and Space Administration (NASA) and Morehouse School of Medicine (MSM) have sustained a 13-year space science education partnership dedicated to these objectives. This paper briefly describes the design and achievements of NSBRI's educational programs, with special emphasis on those initiatives' involvement with IAA and the International Astronautical Congress (IAC). The IAA Commission 2 Draft Report, Space for Africa, is discussed as a model for developing sustainable partnerships and indigenous programs that support Africa's steady emergence as a global space-faring force. The IAC will provide timely: 2011 South Africa will provide timely feedback to refine that report's strategies for space life sciences education and public engagement in Africa and around the globe.

APPLICATION OF A BIP CONSTRAINED OPTIMIZATION MODEL COMBINED WITH NASA's ATLAS MODEL TO OPTIMIZE THE SOCIETAL BENEFITS OF THE USA's INTERNATIONAL SPACE EXPLORATION AND UTILIZATION INITIATIVE OF 1/14/04

NASA Technical Reports Server (NTRS)

Morgenthaler, George W.; Glover, Fred W.; Woodcock, Gordon R.; Laguna, Manuel

2005-01-01

The 1/14/04 USA Space Exploratiofltilization Initiative invites all Space-faring Nations, all Space User Groups in Science, Space Entrepreneuring, Advocates of Robotic and Human Space Exploration, Space Tourism and Colonization Promoters, etc., to join an International Space Partnership. With more Space-faring Nations and Space User Groups each year, such a Partnership would require Multi-year (35 yr.-45 yr.) Space Mission Planning. With each Nation and Space User Group demanding priority for its missions, one needs a methodology for obiectively selecting the best mission sequences to be added annually to this 45 yr. Moving Space Mission Plan. How can this be done? Planners have suggested building a Reusable, Sustainable, Space Transportation Infrastructure (RSSn) to increase Mission synergism, reduce cost, and increase scientific and societal returns from this Space Initiative. Morgenthaler and Woodcock presented a Paper at the 55th IAC, Vancouver B.C., Canada, entitled Constrained Optimization Models For Optimizing Multi - Year Space Programs. This Paper showed that a Binary Integer Programming (BIP) Constrained Optimization Model combined with the NASA ATLAS Cost and Space System Operational Parameter Estimating Model has the theoretical capability to solve such problems. IAA Commission III, Space Technology and Space System Development, in its ACADEMY DAY meeting at Vancouver, requested that the Authors and NASA experts find several Space Exploration Architectures (SEAS), apply the combined BIP/ATLAS Models, and report the results at the 56th Fukuoka IAC. While the mathematical Model is in Ref.[2] this Paper presents the Application saga of that effort.

Sludge Biochar Amendment and Alfalfa Revegetation Improve Soil Physicochemical Properties and Increase Diversity of Soil Microbes in Soils from a Rare Earth Element Mining Wasteland

PubMed Central

Inubushi, Kazuyuki; Liang, Jian; Zhu, Sipin; Wei, Zhenya; Guo, Xiaobin; Luo, Xianping

2018-01-01

Long-term unregulated mining of ion-adsorption clays (IAC) in China has resulted in severe ecological destruction and created large areas of wasteland in dire need of rehabilitation. Soil amendment and revegetation are two important means of rehabilitation of IAC mining wasteland. In this study, we used sludge biochar prepared by pyrolysis of municipal sewage sludge as a soil ameliorant, selected alfalfa as a revegetation plant, and conducted pot trials in a climate-controlled chamber. We investigated the effects of alfalfa revegetation, sludge biochar amendment, and their combined amendment on soil physicochemical properties in soil from an IAC mining wasteland as well as the impact of sludge biochar on plant growth. At the same time, we also assessed the impacts of these amendments on the soil microbial community by means of the Illumina Miseq sequences method. Results showed that alfalfa revegetation and sludge biochar both improved soil physicochemical properties and microbial community structure. When alfalfa revegetation and sludge biochar amendment were combined, we detected additive effects on the improvement of soil physicochemical properties as well as increases in the richness and diversity of bacterial and fungal communities. Redundancy analyses suggested that alfalfa revegetation and sludge biochar amendment significantly affected soil microbial community structure. Critical environmental factors consisted of soil available K, pH, organic matter, carbon–nitrogen ratio, bulk density, and total porosity. Sludge biochar amendment significantly promoted the growth of alfalfa and changed its root morphology. Combining alfalfa the revegetation with sludge biochar amendment may serve to not only achieve the revegetation of IAC mining wasteland, but also address the challenge of municipal sludge disposal by making the waste profitable. PMID:29751652

Sludge Biochar Amendment and Alfalfa Revegetation Improve Soil Physicochemical Properties and Increase Diversity of Soil Microbes in Soils from a Rare Earth Element Mining Wasteland.

PubMed

Luo, Caigui; Deng, Yangwu; Inubushi, Kazuyuki; Liang, Jian; Zhu, Sipin; Wei, Zhenya; Guo, Xiaobin; Luo, Xianping

2018-05-11

Long-term unregulated mining of ion-adsorption clays (IAC) in China has resulted in severe ecological destruction and created large areas of wasteland in dire need of rehabilitation. Soil amendment and revegetation are two important means of rehabilitation of IAC mining wasteland. In this study, we used sludge biochar prepared by pyrolysis of municipal sewage sludge as a soil ameliorant, selected alfalfa as a revegetation plant, and conducted pot trials in a climate-controlled chamber. We investigated the effects of alfalfa revegetation, sludge biochar amendment, and their combined amendment on soil physicochemical properties in soil from an IAC mining wasteland as well as the impact of sludge biochar on plant growth. At the same time, we also assessed the impacts of these amendments on the soil microbial community by means of the Illumina Miseq sequences method. Results showed that alfalfa revegetation and sludge biochar both improved soil physicochemical properties and microbial community structure. When alfalfa revegetation and sludge biochar amendment were combined, we detected additive effects on the improvement of soil physicochemical properties as well as increases in the richness and diversity of bacterial and fungal communities. Redundancy analyses suggested that alfalfa revegetation and sludge biochar amendment significantly affected soil microbial community structure. Critical environmental factors consisted of soil available K, pH, organic matter, carbon⁻nitrogen ratio, bulk density, and total porosity. Sludge biochar amendment significantly promoted the growth of alfalfa and changed its root morphology. Combining alfalfa the revegetation with sludge biochar amendment may serve to not only achieve the revegetation of IAC mining wasteland, but also address the challenge of municipal sludge disposal by making the waste profitable.

QUIJOTE Experiment: status of telescopes and instrumentation

NASA Astrophysics Data System (ADS)

Pérez-de-Taoro, M. R.; Aguiar-González, M.; Cózar-Castellano, J.; Génova-Santos, R.; Gómez-Reñasco, F.; Hoyland, R.; Peláez-Santos, A.; Poidevin, F.; Tramonte, D.; Rebolo-López, R.; Rubiño-Martín, J. A.; Sánchez-de-la-Rosa, V.; Vega-Moreno, A.; Viera-Curbelo, T.; Vignaga, R.; Casas, F. J.; Martinez-Gonzalez, E.; Ortiz, D.; Aja, B.; Artal, E.; Cano-de-Diego, J. L.; de-la-Fuente, L.; Mediavilla, A.; Terán, J. V.; Villa, E.; Harper, S.; McCulloch, M.; Melhuish, S.; Piccirillo, L.; Lasenby, A.

2016-07-01

The QUIJOTE Experiment (Q-U-I JOint TEnerife) is a combined operation of two telescopes and three instruments working in the microwave band to measure the polarization of the Cosmic Microwave Background (CMB) from the northern hemisphere, at medium and large angular scales. The experiment is located at the Teide Observatory in Tenerife, one of the seven Canary Islands (Spain). The project is a consortium maintained by several institutions: the Instituto de Astrofísica de Canarias (IAC), the Instituto de Física de Cantabria (IFCA), the Communications Engineering Department (DICOM) at Universidad de Cantabria, and the Universities of Manchester and Cambridge. The consortium is led by the IAC.

Recent developments with microchannel-plate PMTs

NASA Astrophysics Data System (ADS)

Lehmann, A.; Böhm, M.; Britting, A.; Eyrich, W.; Pfaffinger, M.; Uhlig, F.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

2017-12-01

Microchannel-plate (MCP) PMTs are the favored photon sensors for the DIRC detectors of the PANDA experiment at FAIR. Until recently the main drawback of MCP-PMTs were serious aging effects which led to a limited lifetime due to a rapidly decreasing quantum efficiency (QE) of the photo cathode (PC) as the integrated anode charge (IAC) increased. In the latest models of PHOTONIS and Hamamatsu an innovative atomic layer deposition (ALD) technique is applied to overcome these limitations. During the last five years comprehensive aging tests with ALD coated MCP-PMTs were performed and the results were compared to tubes treated with other techniques. The QE in dependence of the IAC was measured as a function of the wavelength and the position across the PC. For the best performing tubes the lifetime improvement in comparison to the older MCP-PMTs is a factor of > 50 based on an IAC of meanwhile > 10 C /cm2 . In addition, the performance results of a new 2-in. ALD coated MCP-PMT prototype from Hamamatsu with a very high position resolution (128×6 anode pixels) is presented and the first conclusions from investigations concerning the PC aging mechanism will be discussed.

Microstructure and Precipitate's Characterization of the Cu-Ni-Si-P Alloy

NASA Astrophysics Data System (ADS)

Zhang, Yi; Tian, Baohong; Volinsky, Alex A.; Sun, Huili; Chai, Zhe; Liu, Ping; Chen, Xiaohong; Liu, Yong

2016-04-01

Microstructure of the Cu-Ni-Si-P alloy was investigated by transmission electron microscopy (TEM). The alloy had 551 MPa tensile strength, 226 HV hardness, and 36% IACS electrical conductivity after 80% cold rolling and aging at 450 °C for 2 h. Under the same aging conditions, but without the cold rolling, the strength, hardness, and electrical conductivity were 379 MPa, 216 HV, and 32% IACS, respectively. The precipitates identified by TEM characterization were δ-Ni2Si. Some semi-coherent spherical precipitates with a typical coffee bean contrast were found after aging for 48 h at 450 °C. The average diameter of the observed semi-coherent precipitates is about 5 nm. The morphology of the fracture surface was observed by scanning electron microscopy. All samples showed typical ductile fracture. The addition of P refined the grain size and increased the nucleation rate of the precipitates. The precipitated phase coarsening was inhibited by the small additions of P. After aging, the Cu-Ni-Si-P alloy can gain excellent mechanical properties with 804 MPa strength and 49% IACS conductivity. This study aimed to optimize processing conditions of the Cu-Ni-Si-P alloys.

A language based on analogy to communicate cultural concepts in SETI

NASA Astrophysics Data System (ADS)

Musso, Paolo

2011-02-01

The present paper is a synthesis of three presentation given by myself at the Toulouse IAC 2001 ( Analogy as a tool to communicate abstract concepts in SETI), the Bremen IAC 2003 ( From maths to culture: towards an effective message), and the Vancouver IAC 2004 ( Philosophical and religious implications of extraterrestrial intelligent life). Its aim is to find a way to make our cultural concepts understandable to hypothetical extraterrestrials (ETs) in a SETI communication. First of all, I expose the reasons why I think that analogy could be a good tool for this purpose. Then, I try to show that this is possible only in the context of an integrated language, using both abstract symbols and pictures, also sketching two practical examples about some basic concepts of our moral and religious tradition. Further studies are required to determine whether this method could be extended to the higher-level abstract concepts in the other fields of our culture. Finally, I discuss the possible role of mathematics, logic and natural science in the construction of an analogy-based language for interstellar messages with a cultural content and a possible way of managing this matter from a social point of view.

Reduction of low frequency ac losses in coaxial cables of type II superconductors by a steady bias current

NASA Astrophysics Data System (ADS)

LeBlanc, M. A. R.; Cameron, Daniel S. M.; LeBlanc, David; Meng, Jinglei

1996-01-01

Hysteresis losses, Wac, in the core of a monolithic coaxial cable carrying an alternating current of fixed amplitude Iac are predicted to trace a valley as a steady bias current Ibias is superimposed on Iac, when (a) the critical current density jc diminishes with increasing magnetic field H, and/or (b) a Meissner current IM or a surface barrier current ISB opposing flux entry play a role. The predicted Ibias,min where the valley minimum occurs and the value of Wac at the minima are displayed for various IM≥0 and ISB≥0 when jc=α (Bean) and jc=α/H (Kim approximation).

Flow Characteristics and Robustness of an Inclined Quad-vortex Range Hood

PubMed Central

CHEN, Jia-Kun; HUANG, Rong Fung

2014-01-01

A novel design of range hood, which was termed the inclined quad-vortex (IQV) range hood, was examined for its flow and containment leakage characteristics under the influence of a plate sweeping across the hood face. A flow visualization technique was used to unveil the flow behavior. Three characteristic flow modes were observed: convex, straight, and concave modes. A tracer gas detection method using sulfur hexafluoride (SF6) was employed to measure the containment leakage levels. The results were compared with the test data reported previously in the literature for a conventional range hood and an inclined air curtain (IAC) range hood. The leakage SF6 concentration of the IQV range hood under the influence of the plate sweeping was 0.039 ppm at a suction flow rate of 9.4 m3/min. The leakage concentration of the conventional range hood was 0.768 ppm at a suction flow rate of 15.0 m3/min. For the IAC range hood, the leakage concentration was 0.326 ppm at a suction flow rate of 10.9 m3/min. The IQV range hood presented a significantly lower leakage level at a smaller suction flow rate than the conventional and IAC range hoods due to its aerodynamic design for flow behavior. PMID:24583513

Variations in the buccal-lingual alveolar bone thickness of impacted mandibular third molar: our classification and treatment perspectives

PubMed Central

Ge, Jing; Zheng, Jia-Wei; Yang, Chi; Qian, Wen-Tao

2016-01-01

Selecting either buccal or lingual approach for the mandibular third molar surgical extraction has been an intense debate for years. The aim of this observational retrospective study was to classify the molar based on the proximity to the external cortical bone, and analyze the position of inferior alveolar canal (IAC) of each type. Cone-beam CT (CBCT) data of 110 deeply impacted mandibular third molars from 91 consecutive patients were analyzed. A new classification based on the mean deduction value (MD) of buccal-lingual alveolar bone thickness was proposed: MD≥1 mm was classified as buccal position, 1 mm>MD>−1 mm was classified as central position, MD≤−1 mm was classified as lingual position. The study samples were distributed as: buccal position (1.8%) in 2 subjects, central position (10.9%) in 12 and lingual position (87.3%) in 96. Ninety-six molars (87.3%) contacted the IAC. The buccal and inferior IAC course were the most common types in impacted third molar, especially in lingually positioned ones. Our study suggested that amongst deeply impacted mandibular third molars, lingual position occupies the largest proportion, followed by the central, and then the buccal type. PMID:26759181

Adsorption of low concentration ceftazidime from aqueous solutions using impregnated activated carbon promoted by Iron, Copper and Aluminum

NASA Astrophysics Data System (ADS)

Hu, Xiang; Zhang, Hua; Sun, Zhirong

2017-01-01

In this paper, three impregnated activated carbon IAC (AC-Cu, AC-Fe, and AC-Al) promoted by Iron, Copper and Aluminum were used for adsorption of ceftazidime. Iron(III), Copper(II) and Aluminum(III) nitrate were used as an impregnant. The IACs were characterized by scanning electron microscope (SEM), Brunauer-Emmett-Teller (BET) surface area analyzer, Fourier transform infrared spectroscopy (FTIR) and X-ray Photoelectron Spectroscopy (XPS).The influence of factors, such as ion strength, pH, temperature, initial concentration, and concentration of natural organic matter organic matter on the adsorption process were studied. The adsorption kinetics and isotherms of ceftazidime were studied for the three IACs. The results showed that the adsorption was accurately represented by pseudo-second order model. Under different temperature, the maximum adsorption quantity of ceftazidime on AC-Cu calculated by pseudo-second order kinetic model were 200.0 mg g-1 (298 K), 196.1 mg g-1 (303 K) and 185.2 mg g-1 (308 K). It was much higher than that of AC-Fe and AC-Al. And the process was controlled by both film diffusion and intra particle mass transport. The results also showed that, the Freundlich and Temkin isotherm fit the adsorption well.

Internal amplification controls have not been employed in fungal PCR hence potential false negative results.

PubMed

Paterson, R R M

2007-01-01

Polymerase chain reaction (PCR) is subject to false negative results. Samples of fungi with the genes of interest (e.g. a disease or mycotoxin) may be categorized as negative and safe as a consequence. Fungi are eukaryotic organisms that are involved in many fields of human activity such as antibiotic, toxin and food production. Certain taxa are implicated in human, animal and plant diseases. However, fungi are difficult to identify and PCR techniques have been proposed increasingly for this purpose. Internal amplification controls (IACs) will ameliorate the situation and need to become mandatory. These are nucleic acids that posses a sequence which will provide a PCR product (i) using the same primers employed for the target gene, and (ii) that will not coincide on the gel with the product of the target gene. Only one group of workers employed an IAC, to respond to potential inhibition, which was reported in 1995 from this present assessment of numerous reports. Inhibitors in cultures need to be minimized, and secondary metabolites are an obvious source. The fields reviewed herein include medical mycology, mycotoxicology, environmental mycology and plant mycology. The conclusion is that previous reports are compromised because IACs have not been employed in fungal PCR; future research must include this control at an early stage.

In situ microradioscopy and microtomography of fatigue-loaded dental two-piece implants.

PubMed

Wiest, Wolfram; Zabler, Simon; Rack, Alexander; Fella, Christian; Balles, Andreas; Nelson, Katja; Schmelzeisen, Rainer; Hanke, Randolf

2015-11-01

Synchrotron real-time radioscopy and in situ microtomography are the only techniques providing direct visible information on a micrometre scale of local deformation in the implant-abutment connection (IAC) during and after cyclic loading. The microgap formation at the IAC has been subject to a number of studies as it has been proposed to be associated with long-term implant success. The next step in this scientific development is to focus on the in situ fatigue procedure of two-component dental implants. Therefore, an apparatus has been developed which is optimized for the in situ fatigue analysis of dental implants. This report demonstrates both the capability of in situ radioscopy and microtomography at the ID19 beamline for the study of cyclic deformation in dental implants. The first results show that it is possible to visualize fatigue loading of dental implants in real-time radioscopy in addition to the in situ fatigue tomography. For the latter, in situ microtomography is applied during the cyclic loading cycles in order to visualize the opening of the IAC microgap. These results concur with previous ex situ studies on similar systems. The setup allows for easily increasing the bending force, to simulate different chewing situations, and is, therefore, a versatile tool for examining the fatigue processes of dental implants and possibly other specimens.

Time-resolved photometry of the nova remnants DM Gem, CP Lac, GI Mon, V400 Per, CT Ser and XX Tau

NASA Astrophysics Data System (ADS)

Rodríguez-Gil, P.; Torres, M. A. P.

2005-02-01

We present the first results of a photometric survey of poorly studied nova remnants in the Northern Hemisphere. The main results are as follows: DM Gem shows a modulation at 0.123 d (probably linked to the orbit) and rapid variations at ˜ 22 min. A moderate resolution spectrum taken at the time of the photometric observations shows intense He II 4686 and Bowen emission, characteristic of an intermediate polar or a SW Sex star. Variability at 0.127 d and intense flickering (or quasi-periodic oscillations) are the main features of the light curve of CP Lac. A 0.1-mag dip lasting for ˜ 45 min is observed in GI Mon, which could be an eclipse. A clear modulation (probably related to the orbital motion) either at 0.179 d or 0.152 d is observed in the B-band light curve of V400 Per. The results for CT Ser point to an orbital period close to 0.16 d. Intense flickering is also characteristic of this old nova. Finally, XX Tau shows a possible periodic signal near 0.14 d and displays fast variability at ˜ 24 min. Its brightness seems to be modulated at ˜ 5 d. We relate this long periodicity to the motion of an eccentric/tilted accretion disc in the binary. Based in part on observations made with the Jacobus Kapteyn Telescope, which was operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias (IAC), and on observations made with the IAC80 telescope, operated on the island of Tenerife by the IAC in the Spanish Observatorio del Teide of the IAC. Observations were also obtained at the FLWO Observatory, a facility of the Smithsonian Institution.

Stability and adaptability of popcorn genotypes in the State of Rio de Janeiro, Brazil.

PubMed

Pena, G F; do Amaral, A T; Gonçalves, L S A; Candido, L S; Vittorazzi, C; Ribeiro, R M; Freitas, S P

2012-08-31

This study aimed to obtain estimates of stability and adaptability of phase launched materials and materials recommended in the country, for the northern and northwestern regions of Rio de Janeiro State, Brazil, and made a comparative analysis of different methods to evaluate stability and adaptability of grain yield and popping expansion. To this end, 10 genotypes were evaluated (UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, Beija-Flor, IAC 112, IAC 125, Zélia, Jade, and UFVM2 Barão de Viçosa) in five environments. The Yates and Cochran method revealed that genotypes UFV2M Barão de Viçosa, BRS Angela and UNB2U-C3 were the most stable for grain yield. This method also indicated superiority of genotypes UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, IAC 125, and Zélia for popping expansion. The Plaisted and Peterson and Wricke methods demonstrated that genotypes Zélia and UNB2U-C4 were the most productive and stable. These methods indicated genotypes UNB2U-C3 and BRS Angela as the most stable for popping expansion. The Kang and Phan ranking system uses methods based on analysis of variance and classified population UNB2U-C4 as the genotype with the highest stability of grain production and confirmed cultivar BRS Angela as the most stable for popping expansion. Genotypes IAC 112 and UNB2U-C4 were the most stable and adapted for grain yield, according to the Lin and Binns method. The P(i) statistics also ranked UNB2U-C3 and UNB2U-C4 as the genotypes with the best predictability and capacity for popping expansion.

The Instituto de Astrofísica de Canarias: 30 years of Research and Communication in Astronomy.

NASA Astrophysics Data System (ADS)

Del Puerto, Carmen; Rodriguez, Nayra; Rosenberg, Alfred; Beckman, John Etienne

2015-08-01

1985 was a year of inauguration for the Instituto de Astrofísica de Canarias (IAC). In that year its two observatories, the Observatorio del Roque de los Muchachos, on the island of La Palma, (where its 10.4m optical-NIR telescope vies with the world´s major instruments), and the Observatorio del Teide, on the island of Tenerife, as well as its headquarters in La Laguna, Tenerife, were all inaugurated. This young institution has rapidly become the leading research centre for astronomy in Spain and achieved research standards at a European and world level. The 30th anniversary celebrations this year give an opportunity to maximize its already very active outreach programmes. In February two shows, featuring IAC researchers, and with astronomical themes, were shown in the main theatre of the city of La Laguna, and during the year further entertainment, collaborating with Canarian musicians and artists, is planned. Two exhibitions have been designed combining the anniversary with celebrations of the International Year of Light: “Listen to the Universe”, in Tenerife, and “Thirty Journeys around the Sun”, in La Palma, which will be open to the public for most of the year. A new outreach magazine “Parallaxes” will be launched by the IAC, in both paper and digital editions, and will complement the current blog, and news websites of the institute, as well as its communications on Facebook and Twitter. Among the activities being organized in Tenerife will be the formal naming of traffic circles with names of the telescopes at the Observatories. In conjunction with the municipal wine cellars of the local city of Tegueste a new Canarian wine produced by innovative methods and with an astronomical motif on its label, is to be launched during the year. All of these activities are in addition to the somewhat more routine productions of videos on the research lines of the IAC, including exoplanets, solar stellar, and interstellar physics, galaxies, and cosmology.

Robot Design

NASA Technical Reports Server (NTRS)

1988-01-01

Martin Marietta Aero and Naval Systems has advanced the CAD art to a very high level at its Robotics Laboratory. One of the company's major projects is construction of a huge Field Material Handling Robot for the Army's Human Engineering Lab. Design of FMR, intended to move heavy and dangerous material such as ammunition, was a triumph in CAD Engineering. Separate computer problems modeled the robot's kinematics and dynamics, yielding such parameters as the strength of materials required for each component, the length of the arms, their degree of freedom and power of hydraulic system needed. The Robotics Lab went a step further and added data enabling computer simulation and animation of the robot's total operational capability under various loading and unloading conditions. NASA computer program (IAC), integrated Analysis Capability Engineering Database was used. Program contains a series of modules that can stand alone or be integrated with data from sensors or software tools.

Are Patients with Spontaneous CSF Otorrhea and Superior Canal Dehiscence Congenitally Predisposed to Their Disorders?

PubMed

Stevens, Shawn M; Hock, Kiefer; Samy, Ravi N; Pensak, Myles L

2018-04-01

Objectives (1) Compare lateral skull base (LSB) height/thickness in patients with spontaneous cerebrospinal fluid otorrhea (CSF), superior canal dehiscence (SCD), acoustic neuromas (AN), and otosclerosis (OTO). (2) Perform correlations between age, body mass index (BMI), sex, and LSB height/thickness. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods Patients with CSF, SCD, AN, and OTO diagnosed from 2006 to 2016 were included if they had high-definition temporal bone computed tomography (CT) and absence of trauma, radiation, chronic ear disease, and/or congenital anomaly. CT-based measurements included LSB height/thickness and pneumatization rates overlaying the external auditory canal (EAC), tegmen tympani (TgT), perigeniculate region (PG), and internal auditory canal (IAC). LSB height/thickness, age, sex, and BMI were statistically correlated. In total, 256 patients and 493 ears (109 CSF, 115 SCD, 269 AN/OTO) were measured. Results Patients with CSF had significantly higher BMIs than the other groups ( P < .001). Patients with CSF and SCD had similar radiographic LSB phenotypes at most measured locations. Both groups exhibited a significantly lower LSB height compared to the AN and OTO groups (mean, 3.9-4.2 mm vs 4.9-5.6 mm; P < .001). Patients with CSF and SCD also demonstrated significantly lower pneumatization rates, as low as 17% to 23% overlaying the PG and IAC ( P < .001). There were no statistically significant correlations found between age, sex, BMI, and LSB height/thickness at any measurement location in any group. Conclusions Patients with CSF and SCD exhibit similar radiographic LSB phenotypes. Age, sex, and BMI do not significantly correlate with LSB height/thickness. These data support the theory that CSF and SCD arise via similar congenital pathoetiologic mechanisms.

Diphtheria Photos

MedlinePlus

... safe and effective immunization services. IAC also facilitates communication about the safety, efficacy, and use of vaccines within the broad immunization community of patients, parents, healthcare organizations, and government health agencies.

Recombinants from the crosses between amphidiploid and cultivated peanut (Arachis hypogaea) for pest-resistance breeding programs.

PubMed

de Paula, Ailton Ferreira; Dinato, Naiana Barbosa; Vigna, Bianca Baccili Zanotto; Fávero, Alessandra Pereira

2017-01-01

Peanut is a major oilseed crop worldwide. In the Brazilian peanut production, silvering thrips and red necked peanut worm are the most threatening pests. Resistant varieties are considered an alternative to pest control. Many wild diploid Arachis species have shown resistance to these pests, and these can be used in peanut breeding by obtaining hybrid of A and B genomes and subsequent polyploidization with colchicine, resulting in an AABB amphidiploid. This amphidiploid can be crossed with cultivated peanut (AABB) to provide genes of interest to the cultivar. In this study, the sterile diploid hybrids from A. magna V 13751 and A. kempff-mercadoi V 13250 were treated with colchicine for polyploidization, and the amphidiploids were crossed with A. hypogaea cv. IAC OL 4 to initiate the introgression of the wild genes into the cultivated peanut. The confirmation of the hybridity of the progenies was obtained by: (1) reproductive characterization through viability of pollen, (2) molecular characterization using microsatellite markers and (3) morphological characterization using 61 morphological traits with principal component analysis. The diploid hybrid individual was polyploidized, generating the amphidiploid An 13 (A. magna V 13751 x A. kempff-mercadoi V 13250)4x. Four F1 hybrid plants were obtained from IAC OL 4 × An 13, and 51 F2 seeds were obtained from these F1 plants. Using reproductive, molecular and morphological characterizations, it was possible to distinguish hybrid plants from selfed plants. In the cross between A. hypogaea and the amphidiploid, as the two parents are polyploid, the hybrid progeny and selves had the viability of the pollen grains as high as the parents. This fact turns the use of reproductive characteristics impossible for discriminating, in this case, the hybrid individuals from selfing. The hybrids between A. hypogaea and An 13 will be used in breeding programs seeking pest resistance, being subjected to successive backcrosses until recovering all traits of interest of A. hypogaea, keeping the pest resistance.

Recombinants from the crosses between amphidiploid and cultivated peanut (Arachis hypogaea) for pest-resistance breeding programs

PubMed Central

de Paula, Ailton Ferreira; Dinato, Naiana Barbosa

2017-01-01

Peanut is a major oilseed crop worldwide. In the Brazilian peanut production, silvering thrips and red necked peanut worm are the most threatening pests. Resistant varieties are considered an alternative to pest control. Many wild diploid Arachis species have shown resistance to these pests, and these can be used in peanut breeding by obtaining hybrid of A and B genomes and subsequent polyploidization with colchicine, resulting in an AABB amphidiploid. This amphidiploid can be crossed with cultivated peanut (AABB) to provide genes of interest to the cultivar. In this study, the sterile diploid hybrids from A. magna V 13751 and A. kempff-mercadoi V 13250 were treated with colchicine for polyploidization, and the amphidiploids were crossed with A. hypogaea cv. IAC OL 4 to initiate the introgression of the wild genes into the cultivated peanut. The confirmation of the hybridity of the progenies was obtained by: (1) reproductive characterization through viability of pollen, (2) molecular characterization using microsatellite markers and (3) morphological characterization using 61 morphological traits with principal component analysis. The diploid hybrid individual was polyploidized, generating the amphidiploid An 13 (A. magna V 13751 x A. kempff-mercadoi V 13250)4x. Four F1 hybrid plants were obtained from IAC OL 4 × An 13, and 51 F2 seeds were obtained from these F1 plants. Using reproductive, molecular and morphological characterizations, it was possible to distinguish hybrid plants from selfed plants. In the cross between A. hypogaea and the amphidiploid, as the two parents are polyploid, the hybrid progeny and selves had the viability of the pollen grains as high as the parents. This fact turns the use of reproductive characteristics impossible for discriminating, in this case, the hybrid individuals from selfing. The hybrids between A. hypogaea and An 13 will be used in breeding programs seeking pest resistance, being subjected to successive backcrosses until recovering all traits of interest of A. hypogaea, keeping the pest resistance. PMID:28423007

Grain Refinement and Mechanical Properties of Cu–Cr–Zr Alloys with Different Nano-Sized TiCp Addition

PubMed Central

Zhang, Dongdong; Bai, Fang; Wang, Yong; Wang, Jinguo; Wang, Wenquan

2017-01-01

The TiCp/Cu master alloy was prepared via thermal explosion reaction. Afterwards, the nano-sized TiCp/Cu master alloy was dispersed by electromagnetic stirring casting into the melting Cu–Cr–Zr alloys to fabricate the nano-sized TiCp-reinforced Cu–Cr–Zr composites. Results show that nano-sized TiCp can effectively refine the grain size of Cu–Cr–Zr alloys. The morphologies of grain in Cu–Cr–Zr composites changed from dendritic grain to equiaxed crystal because of the addition and dispersion of nano-sized TiCp. The grain size decreased from 82 to 28 μm with the nano-sized TiCp content. Compared with Cu–Cr–Zr alloys, the ultimate compressive strength (σUCS) and yield strength (σ0.2) of 4 wt% TiCp-reinforced Cu–Cr–Zr composites increased by 6.7% and 9.4%, respectively. The wear resistance of the nano-sized TiCp-reinforced Cu–Cr–Zr composites increased with the increasing nano-sized TiCp content. The wear loss of the nano-sized TiCp-reinforced Cu–Cr–Zr composites decreased with the increasing TiCp content under abrasive particles. The eletrical conductivity of Cu–Cr–Zr alloys, 2% and 4% nano-sized TiCp-reinforced Cu–Cr–Zr composites are 64.71% IACS, 56.77% IACS and 52.93% IACS, respectively. PMID:28786937

Silicon influence on resistance induction against Bemisia tabaci biotype B (Genn.) (Hemiptera: Aleyrodidae) and on vegetative development in two soybean cultivars.

PubMed

Ferreira, R S; Moraes, J C; Antunes, C S

2011-01-01

The potential of populations of Bemisia tabaci (Genn.) to become resistant to insecticides has stimulated research into alternative tactics of integrated pest management such as the induction of host-plant resistance. Recent data have shown that silicon can increase the degree of resistance of host plants to insect pests. Therefore the aim of our work was to study the effects of silicon application on the vegetative development of soybean plants and on the induction of resistance to the silverleaf whitefly, B. tabaci biotype B. We performed choice and no-choice tests of oviposition preference on two soybean cultivars, IAC-19 (moderately resistant to B. tabaci biotype B) and MONSOY-8001 (susceptible), with and without application of silicon. Silicon did not affect silverleaf whitefly oviposition preferences, but caused significant mortality in nymphs. Thus, silicon increased the degree of resistance to silverleaf whitefly. Silicon decreased the production of phenolic compounds, but did not affect lignin production. However, when applied to cultivar IAC-19, it increased the production of non-protein organic nitrogen. Silicon had no effect on the vegetative development of soybean plants, but it increased the degree of resistance to the silverleaf whitefly. We conclude that silicon applications combined with cultivar IAC-19 can significantly decrease silverleaf whitefly populations, having a positive impact both on the soybean plant and on the environment.

Underreporting in alcohol surveys: whose drinking is underestimated?

PubMed

Livingston, Michael; Callinan, Sarah

2015-01-01

Population surveys typically produce underestimates of alcohol consumption of approximately 40%-50%. Researchers often undertake a uniform adjustment of survey data to weight estimates such that they match measures of consumption based on sales or tax data. This study explored whether there are differential rates of underestimation in self-reported consumption data by comparing data from two major population surveys in Australia. The study compared survey estimates of consumption for population subgroups from the National Drug Strategy Household Survey (NDSHS, using graduated-frequency questions, coverage = 55%) and the Australian arm of the International Alcohol Control Study (IAC, using within-location beverage-specific questions, coverage = 86%). Analyses examined age- and sex-based subgroups as well as subgroups based on rates of heavy episodic drinking. The graduated-frequency questions (NDSHS) underestimated consumption by 33% compared with the beverage-specific within-location questions (IAC). Underestimates were more marked for young males (40%) and middle-aged females (49%) and less marked for young females (15%) and older females (NDSHS estimates were 19% higher than IAC). Respondents who engaged infrequently or not at all in heavy episodic drinking underestimated their consumption by more (proportionally) than those who did (43% vs. 22%). Underreporting of alcohol consumption in population surveys using standard graduated-frequency questions is not uniform across either demographic or consumption-based subgroups of the population. More robust approaches to adjusting survey data to match objective measures of consumption are required.

75 FR 39089 - Shipping Coordinating Committee; Notice of Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... for updating shipborne navigation and communications equipment --International Telecommunication Union... Classification Societies (IACS) unified interpretations Members of the public may attend this meeting up to the...

Estimate of genetic gain in popcorn after cycles of phenotypic recurrent selection.

PubMed

Ematné, H J; Nunes, J A R; Dias, K O G; Prado, P E R; Souza, J C

2016-05-20

Popcorn is widely consumed in Brazil, yet there are few breeding programs for this crop. Recurrent selection (RS) is a viable breeding alternative for popcorn; however, the gains achieved must be frequently checked. The aim of this study was to assess the effect of selection for grain type (round and pointed) after four cycles of phenotypic RS on the main agronomic traits of popcorn, to estimate the genetic gain achieved for the trait of expansion volume (EV), and to obtain estimates of phenotypic correlations for the main traits of the crop in the UFLA E and UFLA R populations. The zero, one, two, and three cycles of the UFLA E and UFLA R populations, the fourth cycle, and the controls IAC-112 and IAC-125 were used. The experiments were conducted at the experimental farm of Universidade Federal de Lavras (UFLA; Environment 1) and at the experimental area of the Genetics and Plant Breeding Sector of the Department of Biology at UFLA (Environment 2) in the 2010/11 crop season. Nine agronomic traits were evaluated, including EV and grain yield (GY). The UFLA R and UFLA E populations showed similar behavior for all evaluated traits. The type of grain did not affect the genetic gain for EV, which was 5 and 3.7% in each cycle carried out in the UFLA E and UFLA R population, respectively. Phenotypic selection carried out during recombination for EV is an effective method for increasing expression of the trait. EV and GY did not show a linear association.

[Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--1. inhibitary effects of different selenium resources on rat aneuploid cell incidence in mucosal epithelium of gastric antrum].

PubMed

Yang, Wenjie; Li, Weidong; Chen, Jing; Chen, Xiaobin

2007-09-01

To obtain new Se resources with high healthy value (both high activity and low toxicity), the preventive efficacies of three Se-enriched higher plants on stomach cancer were compared with selenite and Se-enriched garlic. Ninety weanling male Wistar rats were fed the basal diet for a week, divided equally into nine groups, control, MNNG,Se 75 and 150 microg/kg bw of selenite, Se 150 and 300 microg/kg bw of Se-enriched garlic, Se 150 microg/kg bw of Se-enriched broccoli, Se 300 microg/kg bw of Se-enriched red kales and green kales group. Rats in MNNG and Se supplementation groups were daily given 15 mg/kg bw of MNNG (solved in 1 ml distilled water) and the rats of control group were given 1 ml distilled water by gavage for ten days. Meanwhile, the rats of the control and MNNG group were daily given 1 ml distilled water and the rats of other groups were given 1 ml water suspension of Se-enriched garlic, red kavas, green kavas, broccoli or 1 ml solution of sodium selenite by gavage for seventeen weeks. All rats were freely fed the basal diet and water during the period of the experiment. At the end of 18th week, the rats were sacrificed, the incidence of aneuploid cells (IAC) in mucosal epithelium of the gastric antrum was detected, and the IAC data were analyzed by SPSS 12.0. The results showed that the IACs were 25% and 30%, respectively, in the Se 150 microg/kg bw of Se-enriched garlic and -broccoli group, and were in turn 22%, 50% and 30% in the 300 microg/kg bw of Se-enriched garlic, -red kale and -green kale. No significant differences of IACs were found in the same level of Se supplementation groups by Se-enriched plants. The data showed that Se-enriched broccoli, red kale and green kale had high activities similar to Se-enriched garlic in stomach cancer prevention and lower toxicity than selenite.

76 FR 36613 - Shipping Coordinating Committee; Notice of Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... IACS unified interpretations. --Development of amendments to the criterion for maximum angle of heel in... request reasonable accommodation, those who plan to attend should contact the meeting coordinator, LCDR...

Cash management and revitalization of public medical centres in Nigeria: a strategic analysis.

PubMed

Agundu, Prince U C; Okon, Godwin B; Robinson, Eric T

2007-01-01

In times like this, when Nigeria (like many other developing countries) is bracing up to the contemporary challenges posed by adoption and advancement of globally driven millennium development goals (MDGs), public medical centers (PMCs) cannot afford to be reckoned with financial epilepsy, bankruptcy, and degeneracy. This concern informed the thrust of the study. In the process, pertinent research questions were posed which elicited corresponding hypothetical propositions. With primary data volunteered by 150 administrative officials drawn from PMCs across the country, analytical proceedings were facilitated by the application of chi-square (x2) technique. The findings brought to the fore, the general bad shape of cash management in PMCs in the country. The recommendations for urgent attention underscored the constitution of strategic budget communities (SBCs), revitalization of internal audit committees (IACs), and attraction of goodwill private-sector endowments through convincing justification of the utilization and optimization of current government logistic subventions.

Development of a sperm cryopreservation protocol for the Argentine black and white tegu (Tupinambis merianae).

PubMed

Young, Carly; Ravida, Nicole; Curtis, Michelle; Mazzotti, Frank; Durrant, Barbara

2017-01-01

Of the 934 lizard species evaluated by the International Union for the Conservation of Nature (IUCN), at least one-third is threatened with extinction. However, there are no reports of semen cryopreservation efforts for lizards. Invasive Argentine black and white tegus were captured in the Florida Everglades, and sperm was collected postmortem. Initial motility score (IMS; % motile × speed of progression 2 × 100), plasma membrane integrity (IPL), and acrosome integrity (IAC) were recorded. Sperm was diluted in TEST-yolk buffer with a final glycerol or dimethylsulfoxide (DMSO)concentration of 8%, 12%, or 16%, and frozen at 0.3 °C, 1.0 °C, or 6.3 °C/min. At thaw, all variables were expressed as the percentage of initial (%IMS, %IPL, and %IAC). The 0.3 °C freeze rate was more successful than 1.0 °C and 6.3 °C/min in preserving %IMS and %IPL. DMSO preserved %IMS, %IPL, and %IAC better than glycerol. To determine the best overall cryopreservation protocol, a sperm quality index was calculated, giving equal weight to each of the three indicators of cryosurvival. Because there were significant interactions between freeze rate and cryoprotectant concentration, each treatment was compared with all others. The sperm quality index analysis revealed that tegu sperm frozen at 0.3 °C/min with 12% DMSO exhibited the highest postthaw viability compared with all other treatments. Copyright © 2016 Elsevier Inc. All rights reserved.

Evaluation of the SO(2) and NH(3) gas adsorption properties of CuO/ZnO/Mn(3)O(4) and CuO/ZnO/NiO ternary impregnated activated carbon using combinatorial materials science methods.

PubMed

Romero, Jennifer V; Smith, Jock W H; Sullivan, Braden M; Macdonald, Landan; Croll, Lisa M; Dahn, J R

2013-02-11

Impregnated activated carbons (IAC) are widely used materials for the removal of toxic gases in personal respiratory protection applications. The combinatorial method has been employed to prepare IACs containing different types of metal oxides in various proportions and evaluate their adsorption performance for low molecular weight gases, such as SO(2) and NH(3), under dry conditions. Among the metal oxides used for the study, Mn(3)O(4) was found to have the highest capacity for retaining SO(2) gas under dry conditions. NiO and ZnO were found to have similar NH(3) adsorption capacities which are higher than the NH(3) capacities observed for the other metal oxide impregnants used in the study. Although Cu- or Zn-based impregnants and their combinations have been extensively studied and used as gas adsorbents, neither Mn(3)O(4) nor NiO have been incorporated in the formulations used. In this study, ternary libraries of IACs with various combinations of CuO/ZnO/Mn(3)O(4) and CuO/ZnO/NiO were studied and evaluated for their adsorption of SO(2) and NH(3) gases. Combinations of CuO, ZnO, and Mn(3)O(4) were found to have the potential to be multigas adsorbents compared to formulations that contain NiO.

Outcome and predicting factors of single and multiple intra-articular corticosteroid injections in children with juvenile idiopathic arthritis.

PubMed

Lanni, Stefano; Bertamino, Marta; Consolaro, Alessandro; Pistorio, Angela; Magni-Manzoni, Silvia; Galasso, Roberta; Lattanzi, Bianca; Calvo-Aranda, Enrique; Martini, Alberto; Ravelli, Angelo

2011-09-01

To investigate the efficacy of IA CS (IAC) therapy in single and multiple joints in children with JIA and to seek for predictors of synovitis flare. The clinical charts of patients who received their first IAC injection between January 2002 and December 2008 were reviewed. The CS used was triamcinolone hexacetonide for large joints and methylprednisolone acetate for small or difficult to access joints. Patients were stratified as follows: one joint injected; two joints injected; and three or more joints injected. Predictors included sex, age at disease onset, JIA category, age and disease duration, ANA status, iridocyclitis, general anaesthesia, number and type of injected joints, acute-phase reactants and concomitant MTX therapy. The cumulative probability of survival without synovitis flare for patients injected in one, two, or three or more joints was 70, 45 and 44%, respectively, at 1 year; 61, 32 and 30%, respectively, at 2 years; and 37, 22 and 19%, respectively, at 3 years. On Cox regression analysis, positive CRP, negative ANA and injection in the ankle were the strongest predictors for synovitis flare. The only significant side effect was skin hypopigmentation or s.c. atrophy, which occurred in <2% of patients. IAC therapy-induced sustained remission of synovitis in a substantial proportion of patients injected either in single or multiple joints, with a good safety profile. The risk of synovitis flare was higher in patients who had positive CRP, negative ANA and were injected in the ankle.

Grain Refinement and Mechanical Properties of Cu-Cr-Zr Alloys with Different Nano-Sized TiCp Addition.

PubMed

Zhang, Dongdong; Bai, Fang; Wang, Yong; Wang, Jinguo; Wang, Wenquan

2017-08-08

The TiC p /Cu master alloy was prepared via thermal explosion reaction. Afterwards, the nano-sized TiC p /Cu master alloy was dispersed by electromagnetic stirring casting into the melting Cu-Cr-Zr alloys to fabricate the nano-sized TiC p -reinforced Cu-Cr-Zr composites. Results show that nano-sized TiC p can effectively refine the grain size of Cu-Cr-Zr alloys. The morphologies of grain in Cu-Cr-Zr composites changed from dendritic grain to equiaxed crystal because of the addition and dispersion of nano-sized TiC p . The grain size decreased from 82 to 28 μm with the nano-sized TiC p content. Compared with Cu-Cr-Zr alloys, the ultimate compressive strength (σ UCS ) and yield strength (σ 0.2 ) of 4 wt% TiC p -reinforced Cu-Cr-Zr composites increased by 6.7% and 9.4%, respectively. The wear resistance of the nano-sized TiCp-reinforced Cu-Cr-Zr composites increased with the increasing nano-sized TiCp content. The wear loss of the nano-sized TiC p -reinforced Cu-Cr-Zr composites decreased with the increasing TiC p content under abrasive particles. The eletrical conductivity of Cu-Cr-Zr alloys, 2% and 4% nano-sized TiCp-reinforced Cu-Cr-Zr composites are 64.71% IACS, 56.77% IACS and 52.93% IACS, respectively.

Development of internal amplification controls for DNA profiling with the AmpFℓSTR(®) SGM Plus(®) kit.

PubMed

Zahra, Nathalie; Hadi, Sibte; Smith, Judith A; Iyengar, Arati; Goodwin, William

2011-06-01

DNA extracted from forensic samples can be degraded and also contain co-extracted contaminants that inhibit PCR. The effects of DNA degradation and PCR inhibition are often indistinguishable when examining a DNA profile. Two internal amplification controls (IACs) were developed to improve quality control of PCR using the AmpFℓSTR® SGM Plus® kit. The co-amplification of these controls with DNA samples was used to monitor amplification efficiency and detect PCR inhibitors. IAC fragments of 90 and 410 bp (IAC₉₀ and IAC₄₁₀) were generated from the plasmid pBR322 using tailed primers and then amplified with ROX-labelled primers. Co-amplification of IAC₉₀ and IAC₄₁₀ was performed with varying amounts of template DNA, degraded DNA and DNA contaminated with humic acid, heme and indigo dye. Both IAC₉₀ and IAC₄₁₀ were successfully amplified with human DNA without significantly affecting the quality of the DNA profile, even with DNA amounts lower than 0.5 ng. In the presence of inhibitors, the IAC₉₀ signal was still present after all human DNA loci fail to amplify; in contrast, the IAC₄₁₀ signal was reduced or absent at low levels of inhibition. Amplification of the two IACs provided an internal PCR control and allowed partial profiles caused by inhibition to be distinguished from degraded DNA profiles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bringing Live Astronomy into the Classroom and to the Public

NASA Astrophysics Data System (ADS)

Cox, Paul

2017-01-01

Slooh makes astronomy incredibly easy, engaging and affordable for anyone with a desire to explore and study the cosmos for themselves. Since 2003 Slooh has connected telescopes to the Internet for access by the public, schools and colleges. Slooh’s fully robotic observatories process FITS data in real-time for broadcast to the Internet. Slooh’s technology is protected by Patent No.: US 7,194,146 B2 which was awarded in 2006.Slooh members have taken over 6-million images of over 50,000 celestial objects, participated in research with leading astronomical institutions, and made over 6,000 Near-Earth Object submissions to the Minor Planet Center. They were also the major contributor of ground based observations of comet 67P/Churyumov-Gerasimenko to the ESA Pro-Am campaign during the Rosetta mission.Slooh’s flagship observatories are located at the Observatorio del Teide, in partnership with the Institute of Astrophysics of the Canary Islands (IAC), and in Chile, in partnership with the Pontificia Universidad Católica de Chile.Slooh’s free live broadcasts of celestial events and phenomena, including eclipses, solar activity, NEAs, comets, lunar cycles, etc. feature narration by astronomy experts Paul Cox and Bob Berman, and are syndicated to media outlets worldwide.Currently in beta, the new "Slooh Classroom" program is due to launch in Q1 2017. This pairs participating schools in the USA to schools in Africa to collaborate on lesson plans that incorporate the use of Slooh's telescopes live in-class.

Tdap Booster Requirements for Secondary Schools

MedlinePlus

... HPV Rubella Influenza Smallpox Measles Tetanus MenACWY Varicella (chickenpox) MenB Zoster (shingles) Mumps View All Pertussis Talking ... TRANSLATE FOR IAC TRAVEL (INTERNATIONAL) UNPROTECTED PEOPLE REPORTS Chickenpox Diphtheria Hepatitis A Hepatitis B >> view all VACCINATING ...

49 CFR 1548.21 - Screening of cargo.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY INDIRECT AIR CARRIER SECURITY § 1548.21 Screening of cargo. An IAC may only screen cargo for transport on a passenger aircraft under §§ 1544.205 and 1546.205...

Ver-i-Fus: an integrated access control and information monitoring and management system

NASA Astrophysics Data System (ADS)

Thomopoulos, Stelios C.; Reisman, James G.; Papelis, Yiannis E.

1997-01-01

This paper describes the Ver-i-Fus Integrated Access Control and Information Monitoring and Management (IAC-I2M) system that INTELNET Inc. has developed. The Ver-i-Fus IAC-I2M system has been designed to meet the most stringent security and information monitoring requirements while allowing two- way communication between the user and the system. The systems offers a flexible interface that permits to integrate practically any sensing device, or combination of sensing devices, including a live-scan fingerprint reader, thus providing biometrics verification for enhanced security. Different configurations of the system provide solutions to different sets of access control problems. The re-configurable hardware interface, tied together with biometrics verification and a flexible interface that allows to integrate Ver-i-Fus with an MIS, provide an integrated solution to security, time and attendance, labor monitoring, production monitoring, and payroll applications.

The Development and Use of Internal Amplification Controls (IACs) with DNA Profiling Kits for Forensic DNA Analysis.

PubMed

Zahra, Nathalie; Goodwin, William

2016-01-01

Biological samples recovered for forensic investigations are often degraded and/or have low amounts of DNA; in addition, in some instances the samples may be contaminated with chemicals that can act as PCR inhibitors. As a consequence this can make interpretation of the results challenging with the possibility of having partial profiles and false negative results. Because of the impact of DNA analysis on forensic investigations, it is important to monitor the process of DNA profiling, in particular the amplification reaction. In this chapter we describe a method for the in-house generation and use of internal amplification controls (IACs) with DNA profiling kits to monitor the success of the PCR proces. In the example we show the use of the SGM Plus® kit. These controls can also be used to aid the interpretation of the DNA profile.

Agrometeorological parameters for prediction of the maturation period of Arabica coffee cultivars

NASA Astrophysics Data System (ADS)

Pezzopane, José Ricardo Macedo; Salva, Terezinha de Jesus Garcia; de Lima, Valéria Bittencourt; Fazuoli, Luiz Carlos

2012-09-01

The objective of this study was to determine the harvest period of coffee fruits based on the relationship between agrometeorological parameters and sucrose accumulation in the seeds. Over the crop years 2004/2005 and 2006/2007, from 150 days after flowering (DAF) onwards, samples of 50 fruits of cultivars Mundo Novo IAC 376-4, Obatã IAC 1669-20 and Catuaí Vermelho IAC 144 were collected from coffee trees located in Campinas, Brazil. The endosperm of the fruits was freeze-dried, ground and analyzed for sucrose content by high-performance liquid chromatography. A weather station provided data to calculate the accumulated growing degree-day (GDD) units, and the reference (ETo) and actual (ETr) evapotranspiration rates. The results showed that the highest rates of sucrose accumulation occurred at the transition from the cane-green to the cherry phenological stage. Models for the estimation of sucrose content during maturation based on meteorological variables exhibited similar or better performance than the DAF variable, with better results for the variables GDD and ETo. The Mundo Novo cultivar reached the highest sucrose level in the endosperm after 2,790 GDD, while cultivar Catuaí attained its maximum sucrose concentration after the accumulated evapotranspiration rate has reached a value of 870 mm. As for cultivar Obatã, the maximum sucrose concentration was predicted with the same degree of accuracy using any of the parameters investigated. For the Obatã cultivar, the values of the variables calculated for the maximum sucrose concentration to be reached were 249 DAF, 3,090 GDD, 1,020 ETo and 900 ETr.

46 CFR 298.11 - Vessel requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... with accepted commercial experience and practice. (g) Metric Usage. Our preferred system of measurement and weights for Vessels and Shipyard Projects is the metric system. ...), classification societies to be ISO 9000 series registered or Quality Systems Certificate Scheme qualified IACS...

46 CFR 298.11 - Vessel requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... with accepted commercial experience and practice. (g) Metric Usage. Our preferred system of measurement and weights for Vessels and Shipyard Projects is the metric system. ...), classification societies to be ISO 9000 series registered or Quality Systems Certificate Scheme qualified IACS...

46 CFR 298.11 - Vessel requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... with accepted commercial experience and practice. (g) Metric Usage. Our preferred system of measurement and weights for Vessels and Shipyard Projects is the metric system. ...), classification societies to be ISO 9000 series registered or Quality Systems Certificate Scheme qualified IACS...

46 CFR 298.11 - Vessel requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... with accepted commercial experience and practice. (g) Metric Usage. Our preferred system of measurement and weights for Vessels and Shipyard Projects is the metric system. ...), classification societies to be ISO 9000 series registered or Quality Systems Certificate Scheme qualified IACS...

46 CFR 298.11 - Vessel requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... with accepted commercial experience and practice. (g) Metric Usage. Our preferred system of measurement and weights for Vessels and Shipyard Projects is the metric system. ...), classification societies to be ISO 9000 series registered or Quality Systems Certificate Scheme qualified IACS...

Improvement of Interoceptive Processes after an 8-Week Body Scan Intervention

PubMed Central

Fischer, Dana; Messner, Matthias; Pollatos, Olga

2017-01-01

Objective: Interoceptive processes are defined as ability to detect sensations arising within the body. There is a growing body of research investigating ways of improving interoceptive processes. One promising approach increasing the attention to bodily sensations is the body scan (BS), a method stemming from mindfulness-based stress reduction. Research so far revealed only heterogenous findings of meditational practice and mindfulness-based stress reduction on interoceptive processes. Even more importantly, there is no study considering the effect of an 8-week BS intervention on interoceptive processes and the distinguishable subdomains of interoception. Therefore, the main objective of this research is to examine the effects of a BS intervention on different interoceptive subdomains over 8 weeks of training in two different samples. Methods: In study 1, healthy participants executed a 20 min standardized audiotaped BS in the BS intervention group (n = 25) each day over 8 weeks. The control group (n = 24) listened to an audio book for the same amount of time. In study 2, the BS group (n = 18) was compared to an inactive control group (n = 18). In both studies, three measurement points were realized and interoceptive accuracy (IAc) – using a heartbeat perception task – as well as interoceptive sensibility (IS) – using confidence ratings for the heartbeat perception task and the subscale ‘interoceptive awareness’ of the Eating Disorder Inventory-2 (EDI-2) – were assessed. Results: In study 1, we found, as a descriptive trend, IAc and confidence ratings to be increased irrespective of the condition. However, post hoc analysis revealed a significant improvement of IAc between T1 and T3 in the BS intervention only. IS revealed to be unaffected by the interventions. In study 2, we observed a significant positive effect of the BS intervention on IAc and confidence ratings compared to the inactive controls. As in study 1, IS (EDI-2) was unaffected by the intervention. Discussion: The results highlight the fact that interoception can be improved by long-term interventions focusing on bodily signals. Further studies might focus on clinical samples showing deficits in interoceptive processes and could use other bodily systems for measurement (e.g., respiratory signals) as well methods manipulating body ownership. PMID:28955213

75 FR 21212 - Approval of Classification Societies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

...-AB35 Approval of Classification Societies AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: Congress requires that classification societies conducting certain work in the United States must either be full members of International Association of Classification Societies (IACS) or...

A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality.

PubMed

Bassetti, Matteo; Righi, Elda; Ansaldi, Filippo; Merelli, Maria; Scarparo, Claudio; Antonelli, Massimo; Garnacho-Montero, Jose; Diaz-Martin, Ana; Palacios-Garcia, Inmaculada; Luzzati, Roberto; Rosin, Chiara; Lagunes, Leonel; Rello, Jordi; Almirante, Benito; Scotton, Pier Giorgio; Baldin, Gianmaria; Dimopoulos, George; Nucci, Marcio; Munoz, Patricia; Vena, Antonio; Bouza, Emilio; de Egea, Viviana; Colombo, Arnaldo Lopes; Tascini, Carlo; Menichetti, Francesco; Tagliaferri, Enrico; Brugnaro, Pierluigi; Sanguinetti, Maurizio; Mesini, Alessio; Sganga, Gabriele; Viscoli, Claudio; Tumbarello, Mario

2015-09-01

Clinical data on patients with intra-abdominal candidiasis (IAC) is still scarce. We collected data from 13 hospitals in Italy, Spain, Brazil, and Greece over a 3-year period (2011-2013) including patients from ICU, medical, and surgical wards. A total of 481 patients were included in the study. Of these, 27% were hospitalized in ICU. Mean age was 63 years and 57% of patients were male. IAC mainly consisted of secondary peritonitis (41%) and abdominal abscesses (30%); 68 (14%) cases were also candidemic and 331 (69%) had concomitant bacterial infections. The most commonly isolated Candida species were C. albicans (n = 308 isolates, 64%) and C. glabrata (n = 76, 16%). Antifungal treatment included echinocandins (64%), azoles (32%), and amphotericin B (4%). Septic shock was documented in 40.5% of patients. Overall 30-day hospital mortality was 27% with 38.9% mortality in ICU. Multivariate logistic regression showed that age (OR 1.05, 95% CI 1.03-1.07, P < 0.001), increments in 1-point APACHE II scores (OR 1.05, 95% CI 1.01-1.08, P = 0.028), secondary peritonitis (OR 1.72, 95% CI 1.02-2.89, P = 0.019), septic shock (OR 3.29, 95% CI 1.88-5.86, P < 0.001), and absence of adequate abdominal source control (OR 3.35, 95% CI 2.01-5.63, P < 0.001) were associated with mortality. In patients with septic shock, absence of source control correlated with mortality rates above 60% irrespective of administration of an adequate antifungal therapy. Low percentages of concomitant candidemia and high mortality rates are documented in IAC. In patients presenting with septic shock, source control is fundamental.

Pharmacokinetics of dexamethasone following intra-articular, intravenous, intramuscular, and oral administration in horses and its effects on endogenous hydrocortisone.

PubMed

Soma, L R; Uboh, C E; Liu, Y; Li, X; Robinson, M A; Boston, R C; Colahan, P T

2013-04-01

This study investigated and compared the pharmacokinetics of intra-articular (IA) administration of dexamethasone sodium phosphate (DSP) into three equine joints, femoropatellar (IAS), radiocarpal (IAC), and metacarpophalangeal (IAF), and the intramuscular (IM), oral (PO) and intravenous (IV) administrations. No significant differences in the pharmacokinetic estimates between the three joints were observed with the exception of maximum concentration (Cmax ) and time to maximum concentration (Tmax ). Median (range) Cmax for the IAC, IAF, and IAS were 16.9 (14.6-35.4), 23.4 (13.5-73.0), and 46.9 (24.0-72.1) ng/mL, respectively. The Tmax for IAC, IAF, and IAS were 1.0 (0.75-4.0), 0.62 (0.5-1.0), and 0.25 (0.08-0.25) h, respectively. Median (range) elimination half-lives for IA and IM administrations were 3.6 (3.0-4.6) h and 3.4 (2.9-3.7) h, respectively. A 3-compartment model was fitted to the plasma dexamethasone concentration-time curve following the IV administration of DSP; alpha, beta, and gamma half-lives were 0.03 (0.01-0.05), 1.8 (0.34-2.3), and 5.1 (3.3-5.6) h, respectively. Following the PO administration, the median absorption and elimination half-lives were 0.34 (0.29-1.6) and 3.4 (3.1-4.7) h, respectively. Endogenous hydrocortisone plasma concentrations declined from a baseline of 103.8 ± 29.1-3.1 ± 1.3 ng/mL at 20.0 ± 2.7 h following the administration of DSP and recovered to baseline values between 96 and 120 h for IV, IA, and IM administrations and at 72 h for the PO. © 2012 Blackwell Publishing Ltd.

Determination of the Avogadro constant by the XRCD method using a 28Si-enriched sphere

NASA Astrophysics Data System (ADS)

Kuramoto, Naoki; Mizushima, Shigeki; Zhang, Lulu; Fujita, Kazuaki; Azuma, Yasushi; Kurokawa, Akira; Okubo, Sho; Inaba, Hajime; Fujii, Kenichi

2017-10-01

To determine the Avogadro constant N A by the x-ray crystal density method, the density of a 28Si-enriched crystal was determined by absolute measurements of the mass and volume of a 1 kg sphere manufactured from the crystal. The mass and volume were determined by an optical interferometer and a vacuum mass comparator, respectively. The sphere surface was characterized by x-ray photoelectron spectroscopy and spectroscopic ellipsometry to derive the mass and volume of the Si core of the sphere excluding the surface layers. From the mass and volume, the density of the Si core was determined with a relative standard uncertainty of 2.3  ×  10-8. By combining the Si core density with the lattice constant and the molar mass of the sphere reported by the International Avogadro Coordination (IAC) project in 2015, a new value of 6.022 140 84(15)  ×  1023 mol-1 was obtained for N A with a relative standard uncertainty of 2.4  ×  10-8. To make the N A value determined in this work usable for a future adjustment of the fundamental constants by the CODATA Task Group on Fundamental Constants, the correlation of the new N A value with the N A values determined in our previous works was examined. The correlation coefficients with the values of N A determined by IAC in 2011 and 2015 were estimated to be 0.07 and 0.28, respectively. The correlation of the new N A value with the N A value determined by IAC in 2017 using a different 28Si-enriched crystal was also examined, and the correlation coefficient was estimated to be 0.21.

Amplification of ST50 gene using dry-reagent-based polymerase chain reaction for the detection of Salmonella typhi.

PubMed

Aziah, Ismail; Ravichandran, Manickam; Ismail, Asma

2007-12-01

Conventional polymerase chain reaction (PCR) testing requires many pipetting steps and has to be transported and stored in cold chain. To overcome these limitations, we designed a ready-to-use PCR test for Salmonella typhi using PCR reagents, primers against the ST50 gene of S. typhi, a built-in internal amplification control (IAC), and gel loading dye mixed and freeze-dried in a single tube. The 2-step dry-reagent-based assay was used to amplify a 1238-bp target gene and an 810-bp IAC gene from 73 BACTEC blood culture broths (33 true positives for S. typhi and 40 true negatives for non-S. typhi). The sensitivity, specificity, positive predictive value, and negative predictive value of the PCR assay were 87.9%, 100%, 100%, and 90.9%, respectively. We suggest that this rapid 2-step PCR test could be used for the rapid diagnosis of typhoid fever.

EMIR electronics AIV and commisioning

NASA Astrophysics Data System (ADS)

Núñez, Miguel; Joven, Enrique; Fernandez, Patricia; Garzón, Francisco; Barreto, Carmen M.; Patrón, Jesús; Mato, Ángel; Moreno, Heidy; Tubio, Oscar; Vega, Nauzet

2016-08-01

EMIR is the NIR imager and multi-object spectrograph common user instrument for the GTC and it has recently passed its first light on sky. EMIR was built by a Consortium of Spanish and French institutes led by the IAC. EMIR has finished its AIV phase at IAC facilities and it is now in commissioning on sky at GTC telescope, having completed the first run. During previous cool downs the EMIR subsystems have been integrated in the instrument progressively for verifying its functionality and performance. In order to fulfil the requirements, prepare the instrument to be in the best conditions for installation in the telescope and to solve unexpected electronics drawbacks, some changes in the implementation have been accomplished during AIV. In this paper it is described the adjustments, modifications and lessons learned related to electronics along AIV stages and the commissioning in the GTC. This includes actions in different subsystems: Hawaii2 detector and its controller electronics, Detector translation Unit, Multi object slit, wheels for filters and grisms, automatisms, vacuum, cryogenics and general electronics.

Studies of the latex of Brazilian IAC series clones from Hevea brasiliensis

USDA-ARS?s Scientific Manuscript database

Natural rubber is an important commodity industrial crop that mainly derives from Hevea brasiliensis. Most natural rubber production is in Southeast Asia, but significant cultivar development takes place in Brazil, the original origin of current commercial H. brasiliensis cultivars. Thus it is criti...

INTERNAL AMPLIFICATION CONTROL FOR USE IN QUANTITATIVE POLYMERASE CHAIN REACTION FECAL INDICATOR BACTERIA ASSAYS

EPA Science Inventory

Quantitative polymerase chain reaction (QPCR) can be used as a rapid method for detecting fecal indicator bacteria. Because false negative results can be caused by PCR inhibitors that co-extract with the DNA samples, an internal amplification control (IAC) should be run with eac...

U.S. EPA, Pesticide Product Label, SPARKLE EMULSION BOWL CLEANER, 02/26/1970

EPA Pesticide Factsheets

2011-04-14

... '11,,,".111,. I.,... 11 fllIllI .,11. Tllil ClEANEI il "'.II'a'otI wi.1I ." 1"lIllti .. , •• w."I", ... i' ,.",ra'" ."d .lIac" ."c",.IO.iatt •• "' • tI ""III IIlIiell',. It", It ... . ...

Molecules in Living Systems: A Biochemistry Module.

ERIC Educational Resources Information Center

Martin, David; Sampugna, Joseph

This book is one in a series of Interdisciplinary Approaches to Chemistry (IAC). The purpose of this guide is to familiarize students with chemistry and its everyday applications around the world using inquiry and investigations. Contents include: (1) "Considering Life Processes"; (2) "Understanding the Structure of Biomolecules"; (3) "Properties…

Accelerating Electronic Tag Development for Tracking Free-Ranging Marine Animals at Sea

DTIC Science & Technology

2007-08-01

for the best in Internet marketing. The IAC Awards are the first and only industry - based advertising award competition dedicated exclusively to...Bioenergetics and diving activity of internesting leatherback turtles Dermochelys coriacea at Parque Nacional Marino Las Baulas, Costa Rica. J. Exp. BioL 208

Polishing and parboiling effect on the nutritional and technological properties of pigmented rice

USDA-ARS?s Scientific Manuscript database

This study aims to evaluate the effects of polishing and parboiling on proximate composition, structure, phenolic compounds, antioxidant activity, cooking time and hardness of IAC-600 black rice cultivar and MPB-10 red rice lineage. Proximate analysis and light micrographs revealed higher migration ...

Review of Techniques for In-Flight Transfer Alignment

DTIC Science & Technology

1992-06-01

Measurements, IEEE Trans. on Aerospace and Electronic Systems, Vol. AES-16. No. 1, Jan. 1980 , pp.53-64. 23. Bar-ltzhack, I.Y., Porat, B.. Azitnuth...WViley 1988. Hlaykin, S. M.-odern F’ilters. .. Iac~lillan Publishers 1989. Hyslop ). C., Geri It. D).. Kraemer, J., GPS/INS Integration -,- the Standoff

40 CFR 52.770 - Identification of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... and Cabinet Coating. (i) Incorporation by reference. (A) Title 326 Air Pollution Control Board...-Photochemically Reactive Hydrocarbon Defined; 326 IAC 8-2-5 Paper Coating Operations. (3) Effective May 18, 1990... March 16, 1972. (2) The Governor submitted Pub. L. 100, Regulation APC 12-R and 13 through 17 on April...

40 CFR 52.719 - Identification of plan-Conditional approval.

Code of Federal Regulations, 2012 CFR

2012-07-01

... limits listed for aerosol- and non aerosol-based antiperspirants and deodorants. 35 IAC 233.205(a)(6)(A) erroneously provides two high-volatility VOC limits for aerosol-based antiperspirants when there should be... provides two medium-volatility VOC limits for non aerosol-based antiperspirants when there should be both a...

40 CFR 52.719 - Identification of plan-Conditional approval.

Code of Federal Regulations, 2013 CFR

2013-07-01

... aerosol-based antiperspirants and deodorants. 35 IAC 233.205(a)(6)(A) erroneously provides two high-volatility VOC limits for aerosol-based antiperspirants when there should be both a high- and medium... limits for non aerosol-based antiperspirants when there should be both a high- and medium-volatility...

Introduction to EGU session "Lunar Science and Exploration Towards Moon Village"

NASA Astrophysics Data System (ADS)

Foing, Bernard

2017-04-01

The EGU PS2.2 session "Lunar Science and Exploration" Towards Moon Village" will address: - Recent lunar results: geochemistry, geophysics in the context of open planetary science and exploration - Synthesis of results from SMART-1, Kaguya, Chang'e 1, 2 and 3, Chandrayaan-1, LCROSS, LADEE, Lunar Reconnaissance Orbiter and, Artemis and GRAIL - Goals and Status of missions under preparation: orbiters, Luna-Glob, Google Lunar X Prize, Luna Resurs polar lander, SLIM, Chandrayaan2, Chang'E 4 & 5, Lunar Resource Prospector, Future landers, Lunar sample return missions - Precursor missions, instruments and investigations for landers, rovers, sample return, and human cis-lunar activities and human lunar surface sorties - Preparation for International Lunar Decade: databases, instruments, missions, terrestrial field campaigns, support studies - ILEWG and Global Exploration roadmaps towards a global robotic/human Moon village - Strategic Knowledge Gaps, and key science Goals relevant to Lunar Global Exploration Lunar science and exploration are developing further with new and exciting missions being developed by China, the US, Japan, India, Russia, Korea and Europe, and with new stakeholders. The Moon Village is an open concept proposed by ESA DG with the goal of a sustainable human and robotic presence on the lunar surface as an ensemble where multiple users can carry out multiple activities. Multiple goals of the Moon Village include planetary science, life sciences, astronomy, fundamental research, resources utilisation, human spaceflight, peaceful cooperation, economical development, inspiration, training and capacity building. ESA director general has revitalized and enhanced the original concept of MoonVillage discussed in the last decade. Space exploration builds on international collaboration. COSPAR and its ILEWG International Lunar Exploration Working Group (created in 1994) have fostered collaboration between lunar missions [4-8]. A flotilla of lunar orbiters has flown in the last international lunar decade (SMART-1, Kaguya, Chang'Eal1 &2, Chandrayaan-1, LCROSS, LRO, GRAIL, LADEE). Chinese Chang'E 3 lander and Yutu rover, and upcoming 2017 other landers from 2017 (GLXP, Chang'E 4 & 5, SLIM, Luna , LRP) will constitute a Robotic Village on the Moon. A number of MoonVillage talks and/or interactive jam sessions have been conducted at International workshops and symposia 2016. Moon Village Workshops were held at ESA centres: they were held with senior experts as well as Young ESA professionals to discuss general topics and specific issues ( habitat design, technology, science and precursor missions; public and stakeholder engagement) . Many workshops were complemented with ILEWG EuroMoonMars simulation campaigns. Moon Village Workshops or Jam sessions were also conducted at international symposia or in collaboration with specific universities or institutes. The PS2.2 session will include invited and contributed talks as well as a panel discussion and interactive posters with short oral introduction. Acknowledgements We thank Prof J. Woerner (ESA DG) for energizing the concept of MoonVillage. We thank co-conveners of MoonVillage Workshops and ILEWG EuroMoonMars field campaigns in 2016 (including C. Jonglez, V.Guinet, M.Monnerie, A. Kleinschneider, A. Kapoglou, A. Kolodziejczyk, M. Harasymczuk, I. Schlacht, C. Heinicke, D. Esser, M.Grulich, T. Siruguet, H.Vos, M.Mirino, D.Sokolsky, J.Blamont) and participants to these events. We thank A.Cowley, C. Haigneré, P. Messina, G. Ortega, S.Cristoforetti, ESA colleagues involved in MoonVillage related activities. We thank colleagues from ILEWG, Young Lunar Explorers, the International Lunar Decade Group, the Moon Village Association and Moon Village Support Groups and "MoonVillagers" at large. [1] Jan Wörner, Driving #MoonVillage http://www.iafastro.org/events/iac/iac-2015/plenaryprogramme/the-moon-a-continent-and-a-gateway-for-ourfuture/ (IAC 2015, Jerusalem); [2]http://www.iafastro.org/events/iac/iac2016/globalnetworking-forum/making-the-moon-village-and-marsjourney-accessible-and-affordable-for-all/ (IAC 2016) ; [3] B. Foing et al , Highlights from Moon Village Workshop, held at ESTEC in December 2015, http://www.hou.usra.edu/meetings/lpsc2016/pdf/2719.pdf, http://www.hou.usra.edu/meetings/lpsc2016/pdf/2798.pdf [4] P. Ehrenfreund et al. "Toward a Global Space Exploration Program: A Stepping Stone Approach" (Advances in Space Research, 49, n°1, January 2012), prepared by COSPAR Panel on Exploration (PEX) [5] http://www.lpi.usra.edu/leag/GER_2011.pdf; [6] http://sci.esa.int/ilewg/47170-gluc-iceum11- beijing-2010lunar-declaration/; [7] http://www.lpi.usra.edu/meetings/leagilewg2008/ [8] http://sci.esa.int/ilewg/41506-iceum9-sorrento- 2007-lunar-declaration/ [9] National Research Council (2007), The Scientific Context for Exploration of the Moon [10] P. Ehrenfreund , B.H. Foing, A. Cellino Editors, The Moon and Near Earth Objects), Advances in Space Research, Volume 37, Issue 1, pp 1-192, 2006 [11] http://sci.esa.int/ilewg/38863-iceum8-beijing- 2006declaration/ [12] W. Huntress, D. Stetson, R. Farquhar, J. Zimmerman, B. Clark, W. O'Neil, R. Bourke& B. Foing,'The next steps in exploring deep space - A cosmic study by the IAA', Acta Astronautica, Vol 58, Issues 6-7, 2006, p302-377 [13]http://sci.esa.int/ilewg/38178-iceum7-toronto-2005-declaration/ [14] H. Balsiger et al. Eds, International Lunar Workshop, 1994 May 31-June 3, Beatenberg, Switzerland. Proceedings. Ed. European Space Agency, 1994. ESA-SP-1170 [15] R.M. Bonnet et al, 'Mission to the Moon, Europe's Priorities for Scientific Exploration and Utilisation of the Moon', European Space Agency, ESA SP-1150, June 1992 [16] http://www.iafastro.org/events/iaf-spring-meetings/spring-meetings-2016/ [17] https://www.spacesymposium.org/ [18] http://www.egu2016.eu/ http://meetingorganizer.copernicus.org/EGU2016/session/20378 [19] https://els2016.arc.nasa.gov/ [20] https://nesf2016.arc.nasa.gov/ [21] https://www.cospar-assembly.org/abstractcd/COSPAR-16/ [22] https://www.iac2016.org/, [23] http://www.hou.usra.edu/meetings/leag2016/presentations/ [24] http://newworlds2016.space/ [25] http://www.stx.ox.ac.uk/happ/events/history-moon [26] https://www.cranfield.ac.uk/events/events-2016/manufacturing-2075#

Communities of Molecules: A Physical Chemistry Module.

ERIC Educational Resources Information Center

DeVoe, Howard

This book is one in the series of Interdisciplinary Approaches to Chemistry (IAC) designed to help students discover that chemistry is a lively science and actively used to pursue solutions to the important problems of today. It is expected for students to see how chemistry takes place continuously all around and to readily understand the daily…

40 CFR 52.797 - Control strategy: Lead.(a)-(b) [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Control strategy: Lead.(a)-(b...: Lead.(a)-(b) [Reserved] (c) On January 12, 1988, Indiana'a Office of Air Management (OAM), Indiana... provisions in 326 IAC 15-1 for Quemetco, Inc., and Refined Metals. Because these efficiencies are closely...

40 CFR 52.797 - Control strategy: Lead.(a)-(b) [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Control strategy: Lead.(a)-(b...: Lead.(a)-(b) [Reserved] (c) On January 12, 1988, Indiana'a Office of Air Management (OAM), Indiana... provisions in 326 IAC 15-1 for Quemetco, Inc., and Refined Metals. Because these efficiencies are closely...

International Advisory Councils and Internationalization of Governance: A Qualitative Analysis

ERIC Educational Resources Information Center

Mihut, Georgiana; Altbach, Philip G.; Salmi, Jamil

2016-01-01

This paper discusses the emergence of international advisory councils (IACs) at universities around the world and introduces the concept of internationalization of governance. Global trends in the field of higher education, such as the quest to create world-class universities and advance in global rankings, the rise of new public management, and…

Improving Memory after Interruption: Exploiting Soft Constraints and Manipulating Information Access Cost

ERIC Educational Resources Information Center

Morgan, Phillip L.; Patrick, John; Waldron, Samuel M.; King, Sophia L.; Patrick, Tanya

2009-01-01

Forgetting what one was doing prior to interruption is an everyday problem. The recent soft constraints hypothesis (Gray, Sims, Fu, & Schoelles, 2006) emphasizes the strategic adaptation of information processing strategy to the task environment. It predicts that increasing information access cost (IAC: the time, and physical and mental effort…

75 FR 73026 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Clean Air Interstate Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... Promulgation of Air Quality Implementation Plans; Indiana; Clean Air Interstate Rule AGENCY: Environmental... State Implementation Plan (SIP) under the Clean Air Act (CAA). The State has submitted amendments to the Indiana Administrative Code (IAC), which supplement Indiana's Clean Air Interstate Rule (CAIR), for which...

Diversity and Periodicity: An Inorganic Chemistry Module.

ERIC Educational Resources Information Center

Huheey, James

This book is one in a series of Interdisciplinary Approaches to Chemistry (IAC) designed to help students discover that chemistry is a lively science and actively used to pursue solutions to the important problems of today. It is expected for students to see how chemistry takes place continuously all around and to readily understand the daily…

Form and Function: An Organic Chemistry Module.

ERIC Educational Resources Information Center

Jarvis, Bruce; Mazzocchi, Paul

This book is one in the series of Interdisciplinary Approaches to Chemistry (IAC) designed to help students discover that chemistry is a lively science and actively used to pursue solutions to the important problems of today. It is expected for students to see how chemistry takes place continuously all around and to readily understand the daily…

[Characterisation of Candida sp. isolated from patients after abdominal surgery].

PubMed

Adámková, V; Vaňková, A; Ulrych, J; Matek, K

2017-01-01

Intraabdominal candidiasis (IAC) is the predominant type of invasive candidiasis after candidemia. The majority of epidemiological studies on Candida are focused only on bloodstream infections. Nevertheless, the role of blood cultures has limited application in patients with abdominal candidiasis. IAC, which includes peritonitis and intraabdominal abscesses, may occur in around 40% of patients following repeat gastrointestinal (GI) surgery or GI perforation. Retrospective analysis of culture isolates of Candida sp. from clinical specimens of patients after abdominal surgery. The study period was from January 1 to October 31, 2016. Our study of 33 patients with findings of Candida sp. from the abdominal cavity found a mortality of 15.2%, the most frequent strain being C. albicans and C. glabrata. All strains of Candida sp. were susceptible to echinocandins. Candida sp. is part of normal microbiota of the gastrointestinal tract and its isolation is often difficult to interpret. Unfortunately, the pathophysiologic importance of Candida isolation from the abdominal space is not completely clear in many clinical situations.Key words: invasive candidiasis intra-abdominal candidiasis laboratory diagnostics.

Interest of the attenuation coefficient in multiparametric high frequency ultrasound investigation of whole blood coagulation process.

PubMed

Callé, Rachel; Plag, Camille; Patat, Frédéric; Ossant, Frédéric

2009-01-01

Previous studies [R. Libgot, F. Ossant, Y. Gruel, P. Lermusiaux, and F. Patat, Proc.-IEEE Utrason. Symp. 4, 2259-2262 (2005); R. Libgot-Calle, F. Ossant, Y. Gruel, P. Lermusiaux, and F. Patat, Ultrasound Med. Biol. 34, 252-264 (2008); F. Ossant, R. Libgot, P. Coupe, P. Lermusiaux, and F. Patat, Proc.-IEEE Ultrason. Symp. 2, 846-849 (2004)] showed the potential of an in vitro high frequency ultrasound (beyond 20 MHz) device to describe the blood clotting process. The parameters were simultaneously estimated in double transmission (DT) with the calculation of the velocity of longitudinal waves and in backscattering (BS) modes with the estimation of the integrated BS coefficient and the effective scatterer size. The aim of the present study was to show how the integrated attenuation coefficient (IAC) assessed in DT mode could provide additional information on this process, especially regarding the fibrin polymerization which is an important part of the coagulation process. A characteristic time t(a) of the variations in IAC that could be linked to fibrin formation was identified.

[Immuno-affinity chromatographic purification: the study of methods to test citrinin in monascus products by high performance liquid chromatography].

PubMed

Qiu, Wen-qian; Liu, Xiao-xia; Zheng, Kui-cheng; Fu, Wu-sheng

2012-08-01

To establish a method to test citrinin (CIT) in monascus products by immuno-affinity chromatography (IAC)-high performance liquid chromatography (HPLC), and to detect the content of CIT in monascus products in Fujian province. IAC-HPLC was applied to detect the CIT content in monascus products. The conditions to use HPLC were as follows: C(18) reversed-phase chromatographic column, 150.0 mm×4.6mm×3 µm; mobile phase: the volume ratio of acetonitrile and 0.1% phosphoric acid solution at 65:35; isocratic elution; column temperature: 28°C; flow velocity: 0.8 ml/min; fluorescence detector, excitation wavelength (λ(ex)) was 331 nm and emission wavelength (λ(em)) was 500 nm. The standard curved was established by the linear regression of peak area (Y) to CIT content (X, ng/ml). The accuracy and precision of the method would then be verified. And 32 kinds of monascus products were determined and their color values were compared by this method. The standard curve established in this study was Y = 4634.8X-136.42, r = 1.000; whose limits of detection was 20 µg/kg and the limits of qualification was 64 µg/kg. In the range between 200 and 800 µg/kg, the standard recovery rate was 98.9% - 110.0% (n = 3), and the relative standard deviation (RSD) was 0.51% - 1.76%. Out of the 32 samples, CIT was detected from 11 samples of monascus rice, 9 samples of monascus powder and 5 samples of monascus pigments, the content was around 0.212 - 14.500 mg/kg. 4 out of 7 functional monascus samples were detected out CIT, whose content at 0.142 - 0.275 mg/kg. The method to detect CIT in monascus products by IAC-HPLC has been established.

Stereotactic radiosurgery planning of vestibular schwannomas: Is MRI at 3 Tesla geometrically accurate?

PubMed

Schmidt, M A; Wells, E J; Davison, K; Riddell, A M; Welsh, L; Saran, F

2017-02-01

MRI is a mandatory requirement to accurately plan Stereotactic Radiosurgery (SRS) for Vestibular Schwannomas. However, MRI may be distorted due not only to inhomogeneity of the static magnetic field and gradients but also due to susceptibility-induced effects, which are more prominent at higher magnetic fields. We assess geometrical distortions around air spaces and consider MRI protocol requirements for SRS planning at 3 T. Hardware-related distortion and the effect of incorrect shimming were investigated with structured test objects. The magnetic field was mapped over the head on five volunteers to assess susceptibility-related distortion in the naso-oro-pharyngeal cavities (NOPC) and around the internal ear canal (IAC). Hardware-related geometric displacements were found to be less than 0.45 mm within the head volume, after distortion correction. Shimming errors can lead to displacements of up to 4 mm, but errors of this magnitude are unlikely to arise in practice. Susceptibility-related field inhomogeneity was under 3.4 ppm, 2.8 ppm, and 2.7 ppm for the head, NOPC region and IAC region, respectively. For the SRS planning protocol (890 Hz/pixel, approximately 1 mm 3 isotropic), susceptibility-related displacements were less than 0.5 mm (head), and 0.4 mm (IAC and NOPC). Large displacements are possible in MRI examinations undertaken with lower receiver bandwidth values, commonly used in clinical MRI. Higher receiver bandwidth makes the protocol less vulnerable to sub-optimal shimming. The shimming volume and the CT-MR co-registration must be considered jointly. Geometric displacements can be kept under 1 mm in the vicinity of air spaces within the head at 3 T with appropriate setting of the receiver bandwidth, correct shimming and employing distortion correction. © 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Hubble Sees 'Ghost Light' From Dead Galaxies

NASA Image and Video Library

2014-10-30

NASA’s Hubble Space Telescope has picked up the faint, ghostly glow of stars ejected from ancient galaxies that were gravitationally ripped apart several billion years ago. The mayhem happened 4 billion light-years away, inside an immense collection of nearly 500 galaxies nicknamed “Pandora’s Cluster,” also known as Abell 2744. The scattered stars are no longer bound to any one galaxy, and drift freely between galaxies in the cluster. By observing the light from the orphaned stars, Hubble astronomers have assembled forensic evidence that suggests as many as six galaxies were torn to pieces inside the cluster over a stretch of 6 billion years. Read more: 1.usa.gov/1yK2Ucp Credit: NASA/ESA/IAC/HFF Team, STScI NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Micromechanics-Based Structural Analysis (FEAMAC) and Multiscale Visualization within Abaqus/CAE Environment

NASA Technical Reports Server (NTRS)

Arnold, Steven M.; Bednarcyk, Brett A.; Hussain, Aquila; Katiyar, Vivek

2010-01-01

A unified framework is presented that enables coupled multiscale analysis of composite structures and associated graphical pre- and postprocessing within the Abaqus/CAE environment. The recently developed, free, Finite Element Analysis--Micromechanics Analysis Code (FEAMAC) software couples NASA's Micromechanics Analysis Code with Generalized Method of Cells (MAC/GMC) with Abaqus/Standard and Abaqus/Explicit to perform micromechanics based FEA such that the nonlinear composite material response at each integration point is modeled at each increment by MAC/GMC. The Graphical User Interfaces (FEAMAC-Pre and FEAMAC-Post), developed through collaboration between SIMULIA Erie and the NASA Glenn Research Center, enable users to employ a new FEAMAC module within Abaqus/CAE that provides access to the composite microscale. FEA IAC-Pre is used to define and store constituent material properties, set-up and store composite repeating unit cells, and assign composite materials as sections with all data being stored within the CAE database. Likewise FEAMAC-Post enables multiscale field quantity visualization (contour plots, X-Y plots), with point and click access to the microscale i.e., fiber and matrix fields).

The Heart of Matter: A Nuclear Chemistry Module.

ERIC Educational Resources Information Center

Viola, Vic

This book is one in a series of Interdisciplinary Approaches to Chemistry (IAC) designed to help students discover that chemistry is a lively science and actively used to pursue solutions to the important problems of today. It is expected for students to see how chemistry takes place continuously all around and to readily understand the daily…

Surface Control of Actuated Hybrid Space Mirrors

DTIC Science & Technology

2010-10-01

precision Nanolaminate foil facesheet and Silicon Carbide ( SiC ) substrate embedded with electroactive ceramic actuators. Wavefront sensors are used to...integrate precision Nanolaminate foil facesheet with Silicon Carbide ( SiC ) substrate equipped with embedded electroactive ceramic actuators...IAC-10.C2.5.8 SURFACE CONTROL OF ACTUATED HYBRID SPACE MIRRORS Brij. N. Agrawal Naval Postgraduate School, Monterey, CA, 93943, agrawal

77 FR 33659 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Consumer Products and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

....205 contain errors in the VOC limits listed for aerosol- and non aerosol-based antiperspirants and... antiperspirants when there should be both a high- and medium-volatility limit for this category. 35 IAC 233.205(a)(6)(B) erroneously provides two medium-volatility VOC limits for non aerosol-based antiperspirants...

Development System for Flexible Assembly System.

DTIC Science & Technology

1986-02-01

in( tho .Iho Iacli: that is, the estimated so’arae hows extrene senisitivity t Ihe t’rr ,f ,rii It: input angles in the vacinity of a pole. These...investigating is to prerotate the world frame so that none of the uncertain transformations have nominal angles in the vacinity of a pole. 17 %% ’ ,’f

Heritability of agronomic traits correlated with reduced stink bug damage in an F2:3 soybean population derived from IAC-100

USDA-ARS?s Scientific Manuscript database

In Brazil, some of the most important insect pests causing damage to soybean (Glycine max) are stink bugs. Soybean production would increase if varieties with enhanced resistance were developed. The aim of this work was to examine different traits associated with plant development, and yield-related...

High genetic diversity of Jatropha curcas assessed by ISSR.

PubMed

Díaz, B G; Argollo, D M; Franco, M C; Nucci, S M; Siqueira, W J; de Laat, D M; Colombo, C A

2017-05-31

Jatropha curcas L. is a highly promising oilseed for sustainable production of biofuels and bio-kerosene due to its high oil content and excellent quality. However, it is a perennial and incipiently domesticated species with none stable cultivar created until now despite genetic breeding programs in progress in several countries. Knowledge of the genetic structure and diversity of the species is a necessary step for breeding programs. The molecular marker can be used as a tool for speed up the process. This study was carried out to assess genetic diversity of a germplasm bank represented by J. curcas accessions from different provenance beside interspecific hybrid and backcrosses generated by IAC breeding programs using inter-simple sequence repeat markers. The molecular study revealed 271 bands of which 98.9% were polymorphic with an average of 22.7 polymorphic bands per primer. Genetic diversity of the germplasm evaluated was slightly higher than other germplasm around the world and ranged from 0.55 to 0.86 with an average of 0.59 (Jaccard index). Cluster analysis (UPGMA) revealed no clear grouping as to the geographical origin of accessions, consistent with genetic structure analysis using the Structure software. For diversity analysis between groups, accessions were divided into eight groups by origin. Nei's genetic distance between groups was 0.14. The results showed the importance of Mexican accessions, congeneric wild species, and interspecific hybrids for conservation and development of new genotypes in breeding programs.

Spanish participation in the development of HARMONI, the first light integral field spectrograph for the E-ELT.

NASA Astrophysics Data System (ADS)

García-Lorenzo, B.; HARMONI Consortium

2015-05-01

HARMONI is the visible and near infrared integral field spectrograph (IFS) selected as a first-light instrument for the European Extremely Large Telescope (E-ELT). With four spatial scales and a range of spectral resolving powers, astronomers will optimally configure the instrument to overtake a wide range of scientific programs and to address many of the E-ELT science cases. The Centro de Astrobiología del CSIC/INTA (CAB-CSIC) and the Instituto de Astrofísica de Canarias (IAC) form part of the international consortium developing HARMONI, participation that will constitute an unique scientific opportunity for the Spanish astronomical community, allowing the access to the E-ELT as soon as it were operative via the guaranteed time. We describe here the instrument and its capabilities with special attention to the Spanish contribution to HARMONI. At the current stage of the project, HARMONI design is being revised due to significant modifications of the Nasmyth platform affecting the interface with HARMONI.

78 FR 16412 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Consent Decree Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or...: Throughout this document whenever ``we,'' ``us,'' or ``our'' is used, we mean EPA. This supplementary... Title V of the Clean Air Act (CAA). EPA is also approving 326 IAC 2-7-10.5(k), which requires public...

75 FR 21364 - Investigations Regarding Certifications of Eligibility to Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

.../10 73845 Ryder Integrated Logistics Georgetown, KY........ 04/05/10 03/05/10 (State/One-Stop). 73846... Marketing (Company). Monroe, LA 04/06/10 03/30/10 73857 The Marlin Firearms North Haven, CT....... 04/06/10...). 73884 Integrated Silicon San Jose, CA 04/08/10 04/07/10 Solution, Inc. (ISSI) (Company). 73885 IAC...

The Effect of Aging on the Microstructure of Selective Laser Melted Cu-Ni-Si

NASA Astrophysics Data System (ADS)

Ventura, Anthony P.; Marvel, Christopher J.; Pawlikowski, Gregory; Bayes, Martin; Watanabe, Masashi; Vinci, Richard P.; Misiolek, Wojciech Z.

2017-12-01

Precipitation hardening copper alloy C70250 was selectively laser melted to successfully produce components around 98 pct dense with high mechanical strength and electrical conductivity. Aging heat treatments were carried out at 723 K (450 °C) directly on as-printed samples up to 128 hours. Mechanical testing found that peak yield strength of around 590 MPa could be attained with an electrical conductivity of 34.2 pct IACS after 8 hours of aging. Conductivity continues to increase with further aging while the peak strength appears to be less sensitive to aging time exhibiting a broad range of time where near-peak properties exist. After aging for 128 hours, there is a drop in yield strength to 546 MPa with an increase in conductivity to 43.2 pct IACS. Electron microscopy analysis revealed nanometer-scale silicon-rich oxide particles throughout the material that persist during aging. Deformation twinning is observed in the peak-age condition after tensile testing and several strengthening mechanisms appear to be active to varying degrees throughout aging which account for the broad range of aging time where nearly the peak mechanical properties exist.

In vivo quantitative analysis of Talin turnover in response to force

PubMed Central

Hákonardóttir, Guðlaug Katrín; López-Ceballos, Pablo; Herrera-Reyes, Alejandra Donají; Das, Raibatak; Coombs, Daniel; Tanentzapf, Guy

2015-01-01

Cell adhesion to the extracellular matrix (ECM) allows cells to form and maintain three-dimensional tissue architecture. Cell–ECM adhesions are stabilized upon exposure to mechanical force. In this study, we used quantitative imaging and mathematical modeling to gain mechanistic insight into how integrin-based adhesions respond to increased and decreased mechanical forces. A critical means of regulating integrin-based adhesion is provided by modulating the turnover of integrin and its adhesion complex (integrin adhesion complex [IAC]). The turnover of the IAC component Talin, a known mechanosensor, was analyzed using fluorescence recovery after photobleaching. Experiments were carried out in live, intact flies in genetic backgrounds that increased or decreased the force applied on sites of adhesion. This analysis showed that when force is elevated, the rate of assembly of new adhesions increases such that cell–ECM adhesion is stabilized. Moreover, under conditions of decreased force, the overall rate of turnover, but not the proportion of adhesion complex components undergoing turnover, increases. Using point mutations, we identify the key functional domains of Talin that mediate its response to force. Finally, by fitting a mathematical model to the data, we uncover the mechanisms that mediate the stabilization of ECM-based adhesion during development. PMID:26446844

Effects of SiC on Properties of Cu-SiC Metal Matrix Composites

NASA Astrophysics Data System (ADS)

Efe, G. Celebi; Altinsoy, I.; Ipek, M.; Zeytin, S.; Bindal, C.

2011-12-01

This paper was focused on the effects of particle size and distribution on some properties of the SiC particle reinforced Cu composites. Copper powder produced by cementation method was reinforced with SiC particles having 1 and 30 μm particle size and sintered at 700 °C. SEM studies showed that SiC particles dispersed in copper matrix homogenously. The presence of Cu and SiC components in composites were verified by XRD analysis technique. The relative densities of Cu-SiC composites determined by Archimedes' principle are ranged from 96.2% to 90.9% for SiC with 1 μm particle size, 97.0 to 95.0 for SiC with 30 μm particle size. Measured hardness of sintered compacts varied from 130 to 155 HVN for SiC having 1 μm particle size, 188 to 229 HVN for SiC having 1 μm particle size. Maximum electrical conductivity of test materials was obtained as 80.0% IACS (International annealed copper standard) for SiC with 1 μm particle size and 83.0% IACS for SiC with 30 μm particle size.

Computerized screening devices and performance assessment: development of a policy towards automation. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.

PubMed

Bartels, P H; Bibbo, M; Hutchinson, M L; Gahm, T; Grohs, H K; Gwi-Mak, E; Kaufman, E A; Kaufman, R H; Knight, B K; Koss, L G; Magruder, L E; Mango, L J; McCallum, S M; Melamed, M R; Peebles, A; Richart, R M; Robinowitz, M; Rosenthal, D L; Sauer, T; Schenck, U; Tanaka, N; Topalidis, T; Verhest, A P; Wertlake, P T; Wilbur, D C

1998-01-01

The extension of automation to the diagnostic assessment of clinical materials raises issues of professional responsibility, on the part of both the medical professional and designer of the device. The International Academy of Cytology (IAC) and other professional cytology societies should develop a policy towards automation in the diagnostic assessment of clinical cytologic materials. The following summarizes the discussion of the initial position statement at the International Expert Conference on Diagnostic Cytology Towards the 21st Century, Hawaii, June 1997. 1. The professional in charge of a clinical cytopathology laboratory continues to bear the ultimate medical responsibility for diagnostic decisions made at the facility, whether automated devices are involved or not. 2. The introduction of automated procedures into clinical cytology should under no circumstances lead to a lowering of standards of performance. A prime objective of any guidelines should be to ensure that an automated procedure, in principle, does not expose any patient to new risks, nor should it increase already-existing, inherent risks. 3. Automated devices should provide capabilities for the medical professional to conduct periodic tests of the appropriate performance of the device. 4. Supervisory personnel should continue visual quality control screening of a certain percentage of slides dismissed at primary screening as within normal limits (WNL), even when automated procedures are employed in the laboratory. 5. Specifications for the design of primary screening devices for the detection of cervical cancer issued by the IAC in 1984 were reaffirmed. 6. The setting of numeric performance criteria is the proper charge of regulatory agencies, which also have the power of enforcement. 7. Human expert verification of results represents the "gold standard" at this time. Performance characteristics of computerized cytology devices should be determined by adherence to defined and well-considered protocols. Manufacturers should not claim a new standard of care; this is the responsibility of the medical community and professional groups. 8. Cytology professionals should support the development of procedures that bring about an improvement in diagnostic decision making. Advances in technology should be adopted if they can help solve problems in clinical cytology. The introduction of automated procedures into diagnostic decision making should take place strictly under the supervision and with the active participation and critical evaluation by the professional cytology community. Guidelines should be developed for the communication of technical information about the performance of automated screening devices by the IAC to governmental agencies and national societies. Also, guidelines are necessary for the official communication of IAC concerns to industry, medicolegal entities and the media. Procedures and guidelines for the evaluation of studies pertaining to the performance of automated devices, performance metrics and definitions for evaluation criteria should be established.

Infrared Heaters

NASA Technical Reports Server (NTRS)

1979-01-01

The heating units shown in the accompanying photos are Panelbloc infrared heaters, energy savers which burn little fuel in relation to their effective heat output. Produced by Bettcher Manufacturing Corporation, Cleveland, Ohio, Panelblocs are applicable to industrial or other facilities which have ceilings more than 12 feet high, such as those pictured: at left the Bare Hills Tennis Club, Baltimore, Maryland and at right, CVA Lincoln- Mercury, Gaithersburg, Maryland. The heaters are mounted high above the floor and they radiate infrared energy downward. Panelblocs do not waste energy by warming the surrounding air. Instead, they beam invisible heat rays directly to objects which absorb the radiation- people, floors, machinery and other plant equipment. All these objects in turn re-radiate the energy to the air. A key element in the Panelbloc design is a coating applied to the aluminized steel outer surface of the heater. This coating must be corrosion resistant at high temperatures and it must have high "emissivity"-the ability of a surface to emit radiant energy. The Bettcher company formerly used a porcelain coating, but it caused a production problem. Bettcher did not have the capability to apply the material in its own plant, so the heaters had to be shipped out of state for porcelainizing, which entailed extra cost. Bettcher sought a coating which could meet the specifications yet be applied in its own facilities. The company asked The Knowledge Availability Systems Center, Pittsburgh, Pennsylvania, a NASA Industrial Applications Center (IAC), for a search of NASA's files

30 CFR 913.25 - Approval of Illinois abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 14, 1993 Ch. 961/2, par. 8001.03; 8002.13. July 2, 1993 September 21, 1993 20 ILCS 1920 §§ 2.11, .13; 62 IAC 2501.37. April 10, 1995 July 11, 1995 Executive Order No. 2 (1995), part I(C); part II(D..., 1989 February 14, 1990 Non-coal reclamation. June 29, 1990 November 2, 1990 Procedures for public...

30 CFR 913.25 - Approval of Illinois abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 14, 1993 Ch. 961/2, par. 8001.03; 8002.13. July 2, 1993 September 21, 1993 20 ILCS 1920 §§ 2.11, .13; 62 IAC 2501.37. April 10, 1995 July 11, 1995 Executive Order No. 2 (1995), part I(C); part II(D..., 1989 February 14, 1990 Non-coal reclamation. June 29, 1990 November 2, 1990 Procedures for public...

30 CFR 913.25 - Approval of Illinois abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 14, 1993 Ch. 961/2, par. 8001.03; 8002.13. July 2, 1993 September 21, 1993 20 ILCS 1920 §§ 2.11, .13; 62 IAC 2501.37. April 10, 1995 July 11, 1995 Executive Order No. 2 (1995), Part I(C); Part II(D..., 1989 February 14, 1990 Non-coal reclamation. June 29, 1990 November 2, 1990 Procedures for public...

30 CFR 913.25 - Approval of Illinois abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 14, 1993 Ch. 961/2, par. 8001.03; 8002.13. July 2, 1993 September 21, 1993 20 ILCS 1920 §§ 2.11, .13; 62 IAC 2501.37. April 10, 1995 July 11, 1995 Executive Order No. 2 (1995), part I(C); part II(D..., 1989 February 14, 1990 Non-coal reclamation. June 29, 1990 November 2, 1990 Procedures for public...

30 CFR 913.25 - Approval of Illinois abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 14, 1993 Ch. 961/2, par. 8001.03; 8002.13. July 2, 1993 September 21, 1993 20 ILCS 1920 §§ 2.11, .13; 62 IAC 2501.37. April 10, 1995 July 11, 1995 Executive Order No. 2 (1995), part I(C); part II(D..., 1989 February 14, 1990 Non-coal reclamation. June 29, 1990 November 2, 1990 Procedures for public...

Gateway: Volume 3 Number 4

DTIC Science & Technology

1992-01-01

applications are described, including windshield, symbols dancing trans- high- flight -time pilots (and big bud- an automobile system that permits driv...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Human Systems JAC 2261 Monahan Way, Bldg. 196 GWIII4 WPAFB OH> 45433-7022 9...release; distribution is unlimited. Free to public by contacting the Human Systems IAC. A 13. ABSTRACT (Maximum 200 Words) This issue contains articles

MASTER Optical Flare Detection from the Fastes Accretor in Our Galaxy - IGR J00291+5934.

NASA Astrophysics Data System (ADS)

Lipunov, V.; Rebolo, R.; Serra-Ricart, M.; Lodieu, N.; Israelian, G.; Lipunov, V.; Gorbovskoy, E.; Kornilov, V.; Balanutsa, P.; Tiurina, N.; Kuznetsov, A.; Chazov, V.; Vlasenko, D.; Gorbunov, I.; Buckley, D.; Potter, S.; Kotze, M.; Gress, O.; Budnev, N. M.; Ivanov, K.; Tlatov, A.; Dormidontov, D.; Senik, V.; Parhomenko, A. V.; Krushinski, V.; Zalozhnykh, I.; Sergienko, Yu.; Gabovich, A.; Yurkov, V.

2015-07-01

MASTER II robotic telescope (MASTER-Net: http://observ.pereplet.ru, Lipunov et al., Advances in Astronomy, MASTER Global Robotic Net, 2010) located in IAC was pointed to the Swift IGR J00291+5934 (Cummings et al., GCN 18051) 24 sec after notice time and 1103 sec after trigger time at 2015-07-24 05:42:03 UT.

Electrophysiological and psychophysical asymmetries in sensitivity to interaural correlation gaps and implications for binaural integration time.

PubMed

Lüddemann, Helge; Kollmeier, Birger; Riedel, Helmut

2016-02-01

Brief deviations of interaural correlation (IAC) can provide valuable cues for detection, segregation and localization of acoustic signals. This study investigated the processing of such "binaural gaps" in continuously running noise (100-2000 Hz), in comparison to silent "monaural gaps", by measuring late auditory evoked potentials (LAEPs) and perceptual thresholds with novel, iteratively optimized stimuli. Mean perceptual binaural gap duration thresholds exhibited a major asymmetry: they were substantially shorter for uncorrelated gaps in correlated and anticorrelated reference noise (1.75 ms and 4.1 ms) than for correlated and anticorrelated gaps in uncorrelated reference noise (26.5 ms and 39.0 ms). The thresholds also showed a minor asymmetry: they were shorter in the positive than in the negative IAC range. The mean behavioral threshold for monaural gaps was 5.5 ms. For all five gap types, the amplitude of LAEP components N1 and P2 increased linearly with the logarithm of gap duration. While perceptual and electrophysiological thresholds matched for monaural gaps, LAEP thresholds were about twice as long as perceptual thresholds for uncorrelated gaps, but half as long for correlated and anticorrelated gaps. Nevertheless, LAEP thresholds showed the same asymmetries as perceptual thresholds. For gap durations below 30 ms, LAEPs were dominated by the processing of the leading edge of a gap. For longer gap durations, in contrast, both the leading and the lagging edge of a gap contributed to the evoked response. Formulae for the equivalent rectangular duration (ERD) of the binaural system's temporal window were derived for three common window shapes. The psychophysical ERD was 68 ms for diotic and about 40 ms for anti- and uncorrelated noise. After a nonlinear Z-transform of the stimulus IAC prior to temporal integration, ERDs were about 10 ms for reference correlations of ±1 and 80 ms for uncorrelated reference. Hence, a physiologically motivated peripheral nonlinearity changed the rank order of ERDs across experimental conditions in a plausible manner. Copyright © 2015 Elsevier B.V. All rights reserved.

Project CHECO Southeast Asia Report. Rules of Engagement - 1 January 1966 - 1 November 1969

DTIC Science & Technology

1969-08-31

O.owngrading of Project CIIECO Report TO: AAC ADC AFAFC AFLC ( Historian ) AFRES AFSC ATC All t-IAC PACAF SAC TAC USA FE USAFSS...k. , ~. t ~ s ipso [aoto a moto ¥>ab?.~ road or· naH. Sc.. an!:fpt-:.~.-.:r,: th:..tt !fOU find a veh-;.cle~ d .;·( .~a’l a5JIOI~ th:u 1..t ~-;f

Rules of Engagement - 1 January 1966 - 1 November 1969

DTIC Science & Technology

1969-08-31

1976 auanc:T: O.owngrading of Project CIIECO Report TO: AAC ADC AFAFC AFLC ( Historian ) AFRES AFSC ATC All t-IAC PACAF SAC TAC USA FE...Z. p󈧙·•k. , ~. t ~ s ipso [aoto a moto ¥>ab?.~ road or· naH. Sc.. an!:fpt-:.~.-.:r,: th:..tt !fOU find a veh-;.cle~ d .;·( .~a’l a5JIOI~ th:u 1

Clinical study on mandibular fracture after marginal resection of the mandible.

PubMed

Okuyama, Kohei; Michi, Yasuyuki; Mizutani, Miho; Yamashiro, Masashi; Kaida, Atsushi; Harada, Kiyoshi

2016-05-01

Postoperative mandibular fracture (PMF) after marginal resection (MR) of the mandible remains an unresolved issue, and it has been reported that at least 10 mm of postoperative mandibular body height (PMBH) is required to prevent PMF. This study evaluated the clinical, physical, and structural risk factors for PMF in MR patients and determined appropriate preventive measures for PMF. This retrospective study included 44 patients with lower gingival carcinoma who underwent MR. PMF occurred in four of these patients. Thirteen associated factors identified from medical records and radiographs were statistically analyzed. Mandibular body height (MBH) preservation ratio originally evaluated as less than 0.3, more than 20 remaining teeth after surgery, and inferior alveolar canal (IAC) exposure were significant risk factors for PMF. Prostheses and number of remaining teeth were also correlated with PMF. The preserved mandibular bone should be reinforced in patients with an MBH preservation ratio of less than 0.3, more than 20 remaining teeth after surgery, and intraoperative IAC exposure. Patients with prostheses are at an increased risk of PMF compared with those without because of stable occlusion and a strong occlusal force. Our novel findings provide useful reference standards for PMF prevention in MR patients. Copyright © 2016 Elsevier Inc. All rights reserved.

The prognostic value of panoramic radiography of inferior alveolar nerve damage after mandibular third molar removal: retrospective study of 400 cases.

PubMed

Szalma, József; Lempel, Edina; Jeges, Sára; Szabó, Gyula; Olasz, Lajos

2010-02-01

The aim of the study was to estimate the accuracy of panoramic radiographic signs predicting inferior alveolar nerve (IAN) paresthesia after lower third molar removal. In a case-control study the sample was composed of 41 cases with postoperative IAN paresthesia and 359 control cases without it. The collected data included "classic" specific signs indicating a close spatial relationship between third molar root and inferior alveolar canal (IAC), root curvatures, and the extent of IAC-root tip overlap. Bivariate and multivariate logistic regression analyses were completed to estimate the association between radiographic findings and IAN paresthesia. The multivariate logistic analysis identified 3 signs significantly associated with IAN paresthesia (P < .001): interruption of the superior cortex of the canal wall, diversion of the canal, and darkening of the root. The sensitivities and specificities ranged from 14.6% to 68.3% and from 85.5% to 96.9%, respectively. The positive predictive values, calculated to factor a 1.1% prevalence of paresthesia, ranged from 3.6% to 10.9%, whereas the negative predictive values >99%. Panoramic radiography is an inadequate screening method for predicting IAN paresthesia after mandibular third molar removal. Copyright (c) 2010 Mosby, Inc. All rights reserved.

Lettuce and rhizosphere microbiome responses to growth promoting Pseudomonas species under field conditions.

PubMed

Cipriano, Matheus A P; Lupatini, Manoeli; Lopes-Santos, Lucilene; da Silva, Márcio J; Roesch, Luiz F W; Destéfano, Suzete A L; Freitas, Sueli S; Kuramae, Eiko E

2016-12-01

Plant growth promoting rhizobacteria are well described and recommended for several crops worldwide. However, one of the most common problems in research into them is the difficulty in obtaining reproducible results. Furthermore, few studies have evaluated plant growth promotion and soil microbial community composition resulting from bacterial inoculation under field conditions. Here we evaluated the effect of 54 Pseudomonas strains on lettuce (Lactuca sativa) growth. The 12 most promising strains were phylogenetically and physiologically characterized for plant growth-promoting traits, including phosphate solubilization, hormone production and antagonism to pathogen compounds, and their effect on plant growth under farm field conditions. Additionally, the impact of beneficial strains on the rhizospheric bacterial community was evaluated for inoculated plants. The strains IAC-RBcr4 and IAC-RBru1, with different plant growth promoting traits, improved lettuce plant biomass yields up to 30%. These two strains also impacted rhizosphere bacterial groups including Isosphaera and Pirellula (phylum Planctomycetes) and Acidothermus, Pseudolabrys and Singusphaera (phylum Actinobacteria). This is the first study to demonstrate consistent results for the effects of Pseudomonas strains on lettuce growth promotion for seedlings and plants grown under tropical field conditions. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Impact of pH on the stability and the cross-reactivity of ochratoxin A and citrinin.

PubMed

Bazin, Ingrid; Faucet-Marquis, Virginie; Monje, Marie-Carmen; El Khoury, Micheline; Marty, Jean-Louis; Pfohl-Leszkowicz, Annie

2013-11-28

Mycotoxins are secondary metabolites produced by several fungi contaminating crops. In several countries, the maximum permitted levels of mycotoxins are found in foodstuffs and feedstuffs. The common strategy of mycotoxin analysis involves extraction, clean-up and quantification by chromatography. In this paper, we analyzed the reasons of underestimation of ochratoxin A (OTA) content in wine, and overestimation of OTA in wheat, depending on the pH of the clean-up step and the simultaneous presence of citrinin (CIT). We demonstrated that the increase of pH by adding polyethylene glycol (PEG) to wine led to an underestimation of OTA by conversion of OTA into open ring ochratoxin A OP-OA. In comparing three methods of extraction and clean-up for the determination of OTA and CIT in wheat--(i) an inter-laboratory validated method for OTA in cereals using immunoaffinity column clean-up (IAC) and extraction by acetonitrile/water; (ii) a validated method using IAC and extraction with 1% bicarbonate Na; and (iii) an in-house validated method based on acid liquid/liquid extraction--we observed an overestimation of OTA after immunoaffinity clean-up when CIT is also present in the sample, whereas an underestimation was observed when OTA was alone. Under neutral and alkaline conditions, CIT was partially recognized by OTA antibodies.

Relationship between CT densitometry with a slice thickness of 0.5 mm and audiometry in otosclerosis.

PubMed

Kawase, Setsuko; Naganawa, Shinji; Sone, Michihiko; Ikeda, Mitsuru; Ishigaki, Takeo

2006-06-01

The appropriate cutoff Hounsfield unit (HU) value for the diagnosis of otosclerosis was determined and the correlation between the bone conduction threshold and the findings of computed tomography (CT) densitometry investigated. CT images, 0.5-mm thick, were evaluated in 24 ears with otosclerosis and 19 control ears. Eight regions of interest were set around the otic capsule. The mean HU values in the area anterior to the oval window (A-OW) and anterior to the internal auditory canal (A-IAC) were significantly lower in otosclerosis than in controls. Based on receiver operating characteristic (ROC) analysis, the cutoff HU value in A-OW was determined to be 2,187.3 HU. The mean HU value in retrofenestral otosclerosis was significantly lower in the area A-OW, A-IAC and around the cochlea than in controls. Based on ROC analysis, the cutoff HU value in the latter was determined to be 2,045 HU. A statistically significant correlation was found between the density of the area A-OW and the hearing level at 500 and 1,000 Hz, and between the density of the area around the cochlea and the hearing level at most frequencies. These results suggest the semi-automated diagnosis of otosclerosis may be possible.

Changes in interoceptive processes following brain stimulation

PubMed Central

Mai, Sandra

2016-01-01

The processing and perception of individual internal bodily signals (interoception) has been differentiated to comprise different levels and processes involved. The so-called heartbeat-evoked potential (HEP) offers an additional possibility to examine automatic processing of cardiac signals. Knowledge on neural structures potentially supporting different facets of interoception is still sparse. One way to get insights into neuroanatomical function is to manipulate the activity of different brain structures. In this study, we used repetitive transcranial magnetic stimulation (rTMS) and a continuous theta-burst protocol to inhibit specific central locations of the interoceptive network including the right anterior insula and the right somatosensory cortices and assessed effects on interoceptive facets and the HEP in 18 male participants. Main results were that inhibiting anterior insula resulted in a significant decline in cardiac and respiratory interoceptive accuracy (IAc) and in a consistent decrease in perception confidence. Continuous theta-burst stimulation (cTBS) over somatosensory cortices reduced only cardiac IAc and affected perception confidence. Inhibiting right anterior insula and right somatosensory cortices increased interoceptive sensibility and reduced the HEP amplitude over frontocentral locations. Our findings strongly suggest that cTBS is an effective tool to investigate the neural network supporting interoceptive processes. This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’. PMID:28080973

Improved compliance with reporting standards: A retrospective analysis of Intersocietal Accreditation Commission Nuclear Cardiology Laboratories.

PubMed

Maddux, P Tim; Farrell, Mary Beth; Ewing, Joseph A; Tilkemeier, Peter L

2018-06-01

In 2011, Tilkemeier et al reported significant nuclear cardiology laboratory noncompliance with reporting standards. The aim of this study was to identify and examine noncompliant reporting elements with the Intersocietal Accreditation Commission Nuclear/PET (IAC) Reporting Standards and to compare compliance between 2008 and 2014. This was a retrospective study of compliance with 18 reporting elements utilizing accreditation findings from all laboratories applying for accreditation in 2008 and 2014. 1816 labs applying for initial or subsequent accreditation were analyzed for compliance. The mean reporting noncompliance per lab decreased from 2008 to 2014 (2.48 ± 2.67 to 1.24 ± 1.79, P < .001). Noncompliance decreased across lab types, labs with Certification Board of Nuclear Cardiology physicians on staff, and by geographic region (P < .001). Overall severity of reporting issues decreased. Facilities with compliant reports increased from 35.0% in 2008 to 57.1% in 2014 (P < .001). Continuing medical education, accreditation, and other instructional activities aimed at improving nuclear cardiology reporting appear to have made a positive impact over time with the number and severity of noncompliance decreased. More labs are now compliant with the IAC Standards and, thus, reporting guidelines. However, the need for continued educational efforts remains.

Field-based evaluation of a male-specific (F+) RNA coliphage ...

EPA Pesticide Factsheets

Fecal contamination of water poses a significant risk to public health due to the potential presence of pathogens, including enteric viruses. Thus, sensitive, reliable and easy to use methods for the detection of microorganisms are needed to evaluate water quality. In this study, we performed a field evaluation of an anion-exchange resin based platform to concentrate F-RNA coliphages (fecal/enteric virus indicators) from diverse fecally impacted environmental waters. In this platform, F-RNA coliphages are adsorbed to anion-exchange resin and direct nucleic acid isolation is performed, yielding a sample amenable to real-time reverse transcriptase PCR detection. Matrix-dependent inhibition was evaluated using known quantities of spiked F-RNA coliphage genogroups GI, GII, GII and GIV. Detection was successful in 97%, 72%, 85% and 98% of the samples for spiked F-RNA coliphage GI, GII, GIII and GIV, respectively, and was differentially affected by inhibitory properties specific to each water sample. No association between inhibition and the water samples’ physicochemical properties was apparent. Parallel evaluations of the spiked samples with internal amplification control (IAC) reactions (a widely used control to assess inhibition) demonstrated that IAC reaction inhibition was not agreement with that observed for spiked samples, suggesting that testing of spiked samples allows for better assessments of matrix-dependent inhibition. Additionally, the anion-

Impact of pH on the Stability and the Cross-Reactivity of Ochratoxin A and Citrinin

PubMed Central

Bazin, Ingrid; Faucet-Marquis, Virginie; Monje, Marie-Carmen; El Khoury, Micheline; Marty, Jean-Louis; Pfohl-Leszkowicz, Annie

2013-01-01

Mycotoxins are secondary metabolites produced by several fungi contaminating crops. In several countries, the maximum permitted levels of mycotoxins are found in foodstuffs and feedstuffs. The common strategy of mycotoxin analysis involves extraction, clean-up and quantification by chromatography. In this paper, we analyzed the reasons of underestimation of ochratoxin A (OTA) content in wine, and overestimation of OTA in wheat, depending on the pH of the clean-up step and the simultaneous presence of citrinin (CIT). We demonstrated that the increase of pH by adding polyethylene glycol (PEG) to wine led to an underestimation of OTA by conversion of OTA into open ring ochratoxin A OP-OA. In comparing three methods of extraction and clean-up for the determination of OTA and CIT in wheat—(i) an inter-laboratory validated method for OTA in cereals using immunoaffinity column clean-up (IAC) and extraction by acetonitrile/water; (ii) a validated method using IAC and extraction with 1% bicarbonate Na; and (iii) an in-house validated method based on acid liquid/liquid extraction—we observed an overestimation of OTA after immunoaffinity clean-up when CIT is also present in the sample, whereas an underestimation was observed when OTA was alone. Under neutral and alkaline conditions, CIT was partially recognized by OTA antibodies. PMID:24287570

U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lipman, Tim; Kammen, Dan; McDonell, Vince

2013-09-30

The U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC) was formed in 2009 by the U.S. Department of Energy (DOE) and the California Energy Commission to provide education, outreach, and technical support to promote clean energy -- combined heat and power (CHP), district energy, and waste energy recovery (WHP) -- development in the Pacific Region. The region includes California, Nevada, Hawaii, and the Pacific territories. The PCEAC was operated as one of nine regional clean energy application centers, originally established in 2003/2004 as Regional Application Centers for combined heat and power (CHP). Under the Energy Independence andmore » Security Act of 2007, these centers received an expanded charter to also promote district energy and waste energy recovery, where economically and environmentally advantageous. The centers are working in a coordinated fashion to provide objective information on clean energy system technical and economic performance, direct technical assistance for clean energy projects and additional outreach activities to end users, policy, utility, and industry stakeholders. A key goal of the CEACs is to assist the U.S. in achieving the DOE goal to ramp up the implementation of CHP to account for 20% of U.S. generating capacity by 2030, which is estimated at a requirement for an additional 241 GW of installed clean technologies. Additional goals include meeting the Obama Administration goal of 40 GW of new CHP by 2020, key statewide goals such as renewable portfolio standards (RPS) in each state, California’s greenhouse gas emission reduction goals under AB32, and Governor Brown’s “Clean Energy Jobs Plan” goal of 6.5 GW of additional CHP over the next twenty years. The primary partners in the PCEAC are the Department of Civil and Environmental Engineering and the Energy and Resources Group (ERG) at UC Berkeley, the Advanced Power and Energy Program (APEP) at UC Irvine, and the Industrial Assessment Centers (IAC) at San Diego State University and San Francisco State University. The center also worked with a wide range of affiliated groups and industry, government, NGO, and academic stakeholders to conduct a series of CHP education and outreach, project technical support, and related activities for the Pacific region. Key PCEAC tasks have included: - Preparing, organizing and conducting educational seminars on various aspects of CHP - Conducting state baseline assessments for CHP - Working with state energy offices to prepare state CHP action plans - Providing technical support services including CHP/district energy project feasibility screenings - Working with state agencies on CHP policy development - Developing additional CHP educational materials The primary specific services that PCEAC has offered include: - A CHP “information clearinghouse “ website: http://www.pacificcleanenergy.org - Site evaluations and potential projects screenings - Assessment of CHP status, potential, and key issues for each state - Information and training workshops - Policy and regulatory guidance documents and other interactions These services were generally offered at no cost to client groups based on the DOE funding and additional activities supported by the California Energy Commission, except for the in-kind staff resources needed to provide input data and support to PCEAC assessments at host sites. Through these efforts, the PCEAC reached thousands of end-users and directly worked with several dozen organizations and potential CHP “host sites” from 2009-2013. The major activities and outcomes of PCEAC project work are described.« less

Diffraction Effects in Directed Radiation Beams

DTIC Science & Technology

1990-04-03

cosP acosO )/sin a sinJ], 0 / ’V< a , and Oga cos’ j (a-ct)/Yj, ()< 13 a < Rt/2, and where (r, t) is ident ical to t (I- t ) e:.:cep• that a i1 IepIac ed...Toraldo di Francia , NuoVo Cimento, Suppl. 9, 426 (1952)> 3. W T. Welford, Qptics, (Onfordi University Press, New York, 1981), chap. 3. 4. C.. J. Bouwkarnp

Recovering star formation histories: Integrated-light analyses vs. stellar colour-magnitude diagrams

NASA Astrophysics Data System (ADS)

Ruiz-Lara, T.; Pérez, I.; Gallart, C.; Alloin, D.; Monelli, M.; Koleva, M.; Pompei, E.; Beasley, M.; Sánchez-Blázquez, P.; Florido, E.; Aparicio, A.; Fleurence, E.; Hardy, E.; Hidalgo, S.; Raimann, D.

2015-11-01

Context. Accurate star formation histories (SFHs) of galaxies are fundamental for understanding the build-up of their stellar content. However, the most accurate SFHs - those obtained from colour-magnitude diagrams (CMDs) of resolved stars reaching the oldest main-sequence turnoffs (oMSTO) - are presently limited to a few systems in the Local Group. It is therefore crucial to determine the reliability and range of applicability of SFHs derived from integrated light spectroscopy, as this affects our understanding of unresolved galaxies from low to high redshift. Aims: We evaluate the reliability of current full spectral fitting techniques in deriving SFHs from integrated light spectroscopy by comparing SFHs from integrated spectra to those obtained from deep CMDs of resolved stars. Methods: We have obtained a high signal-to-noise (S/N ~ 36.3 per Å) integrated spectrum of a field in the bar of the Large Magellanic Cloud (LMC) using EFOSC2 at the 3.6-metre telescope at La Silla Observatory. For this same field, resolved stellar data reaching the oMSTO are available. We have compared the star formation rate (SFR) as a function of time and the age-metallicity relation (AMR) obtained from the integrated spectrum using STECKMAP, and the CMD using the IAC-star/MinnIAC/IAC-pop set of routines. For the sake of completeness we also use and discuss other synthesis codes (STARLIGHT and ULySS) to derive the SFR and AMR from the integrated LMC spectrum. Results: We find very good agreement (average differences ~4.1%) between the SFR (t) and the AMR obtained using STECKMAP on the integrated light spectrum, and the CMD analysis. STECKMAP minimizes the impact of the age-metallicity degeneracy and has the advantage of preferring smooth solutions to recover complex SFHs by means of a penalized χ2. We find that the use of single stellar populations (SSPs) to recover the stellar content, using for instance STARLIGHT or ULySS codes, hampers the reconstruction of the SFR (t) and AMR shapes, yielding larger discrepancies with respect to the CMD results. These discrepancies can be reduced if spectral templates based on known and complex SFHs are employed rather than SSPs. Based on observations obtained at the 3.6 m ESO telescope on La Silla (Chile) and with the Hubble Space Telescope, operated by NASA.Appendices are available in electronic form at http://www.aanda.org

The Swedish Interplanetary Society (1950-1969) and the formation of IAF and IAA

NASA Astrophysics Data System (ADS)

Ingemar Skoog, A.

2011-06-01

With a growing interest for rocket technology and space travel after WW II a number of new "space societies" were formed in the period 1948-1951 in addition to the ones already existing in Germany, the UK and the US since before WW II. Soon came the need for a common international platform for exchange of information and experience, and the concept of an international federation of astronautical societies emerged. Sweden was one of the 8 countries to sign the original declaration to create an International Astronautical Federation on October 2, 1950 in Paris at the 1st International Astronautical Congress. The Swedish Society for Space Research (Svenska Sällskapet för Rymdforskning) was formed a few days after the historical event in Paris. The name was soon to be changed to the Swedish Interplanetary Society (Svenska Interplanetariska Sällskapet, SIS). Sweden was one of the 10 countries to sign the IAF foundation in 1951 in London and in the following year the first Constitution of IAF in Stuttgart. The SIS quickly grow to a membership of several hundred persons and its membership in IAF promoted an intensive exchange of journals, and the annual participation at the IAC gave growth to start study projects on spacecraft and sounding rockets, and the publication of astronautical journals in Swedish. In 1957 the first Swede was elected vice-president of IAF. Not too long after the IAF foundation the idea of an international body of distinguished individuals emerged, in addition to the body of "member societies" (IAF). Upon the initiative of Theodor von Karman, Eugen Sänger and Andrew Haley the IAF council approval of an International Academy of Astronautical was given on August 15, 1960 during the 11th IAC in Stockholm. This IAC in Stockholm gave a large publicity to space research and astronautics in Sweden, and put the activities of the SIS in the focus of the general public. This paper presents the Swedish involvement in the foundation of IAF and IAA. It also gives an overview on the positive influence of these two organisations on the work and progress of the Swedish Interplanetary Society and the diffusion of astronautics to the general public in Sweden.

Sistemas Correctores de Campo Para EL Telescopio Cassegrain IAC80

NASA Astrophysics Data System (ADS)

Galan, M. J.; Cobos, F. J.

1987-05-01

El proyecto de instrumentación de mayor importancia que ha tenido el Instituto de Astrofisica de Canarias en los últimos afios ha sido el diseflo y construcción del te1escopio IAC8O. Este requería del esfuerzo con junto en mec´nica, óptica y electrónica, lo que facilitó la estructuración y el crecimiento de los respectivos grupos de trabajo, que posteriormente se integraron en departamentos En su origen (1977), el telescopio IAC80 fue concebido como un sistema clásico tipo Cassegrain, con una razón focal F/i 1.3 para el sistema Casse grain y una razón focal F/20 para el sistema Coudé. Posteriormente, aunque se mantuvo la filosofia de que el sistema básico fuera el F/11.3, se consideró conveniente el diseño de secundarios para razones focales F/16 y F/32, y se eliminó el de F/20. Sin embargo, dada la importancia relativa que un foco estrictamente fotográfico tiene en un telescopio moderno, diseñado básicamente para fotometría fotoeléctrica y con un campo util mínimamente de 40 minutos de arco, se decídió Ilevar a cabo el diseño de un secundario F/8 con un sistema corrector de campo, pero que estuviera formado únicamente por lentes con superficies esféricas para que asl su construcción fuera posible en España ó en México. La creciente utilización de detectores bidimensionales para fines de investigación astron6mica y la viabilidad de que en un futuro cercano éstos tengan un área sensible cada vez mayor, hicieron atractiva la idea de tener diseñado un sistema corrector de campo para el foco primario (F/3), con un campo útil mínimo de un grado, y también con la limitante de que sus componentes tuvieron sólamente supérficies esféricas. Ambos diseños de los sis-temas correctores de campo se llevaron a cabo, en gran medida, como parte de un proyecto de colaboración e intercambio en el área de diseño y evaluación de sistemas ópticos.

VizieR Online Data Catalog: Optical ident. and redshifts of Planck SZ sources (Planck+, 2016)

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Levy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Boehringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burenin, R.; Burigana, C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colombo, L. P. L.; Combet, C.; Comis, B.; Crill, B. P.; Curto, A.; Cuttaia, F.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; De Rosa, A.; de Zotti, G.; Delabrouille, J.; Diego, J. M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T. A.; Eriksen, H. K.; Ferragamo, A.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Galli, S.; Ganga, K.; Genova-Santos, R. T.; Giard, M.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorski, K. M.; Gruppuso, A.; Hansen, F. K.; Harrison, D. L.; Hempel, A.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Keihaenen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Leon-Tavares, J.; Levrier, F.; Lietzen, H.; Liguori, M.; Lilje, P. B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P. M.; Macias-Perez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; McGehee, P.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Miville-Deschenes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Perdereau, O.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen J. P.; Rebol, O. R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubino-Martin, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Stolyarov, V.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Valenziano, L.; Valiviita, J.; van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-04-01

This article is a companion paper to the Planck catalogue of SZ sources (PSZ1) published in Planck Collaboration XXIX (2014, Cat. J/A+A/581/A14). It contains the results of approximately three years of observations with telescopes at the Canary Islands observatories (IAC80, NOT, INT, TNG, WHT, and GTC), as part of the general optical follow-up programme undertaken by the Planck Collaboration. (2 data files).

A Report to the President of the United States [from the] Intergovernmental Advisory Council on Education, National Networking Conference [on] The Absent Parent (Washington, D.C. May 9-10, 1988).

ERIC Educational Resources Information Center

Intergovernmental Advisory Council on Education (ED), Washington, DC.

This report on child care and the Federal government's role in child care is based on the National Networking Conference on the Absent Parent which was held May 9-10, 1988 under the sponsorship of the President's Intergovernmental Advisory Council on Education (IACE). The report begins with 12 recommendations concerning day care and latchkey…

MASTER follow up observation of MAXIJ1727-203

NASA Astrophysics Data System (ADS)

Lipunov, V.; Buckley, D.; Rebolo, R.; Serra-Ricart, M.; Kornilov, V.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Gorbunov, I.; Kuznetsov, A.; Vladimirov, V.; Gress, O.; Pogrosheva, T.; Vlasenko, D.

2018-06-01

MASTER Global Robotic Net observed MAXI X-ray transient source ( T. Yoneyama et al. ATEL #11683) RA,Dec(2000)=17 27 53, -20 23 20 +-0.33d. We confirm GROND OT ( Arne Rau et al. ATEL #11690) MASTER-IAC auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) detected MASTER OT J172829.90-202255.91 (1sigma 0.7arcsec) on 2018-06-05 21:52:53.344 (10exp.

Fingerprinting of Non-resolved Three-axis Stabilized Space Objects Using a Two-Facet Analytical Model

DTIC Science & Technology

2011-09-01

Crawford, K., " Time - Resolved Infrared Spectrophotometric Observations of IRIDIUM satellites and related Resident Space Objects", IAC-09-A6.1.17...Figure 10 for a geosynchronous (GEO) satellite . The figure shows three sets of multi-spectral signatures were collected at different times of the...provides a simple method to determine suitable observation conditions for the cluster of satellites . For instance, on Day 0, the times of the

Differential interactions between Curtobacterium flaccumfaciens pv. flaccumfaciens and common bean.

PubMed

Valdo, S C D; Wendland, A; Araújo, L G; Melo, L C; Pereira, H S; Melo, P G; Faria, L C

2016-11-21

Bacterial wilt of common bean caused by Curtobacterium flaccumfaciens pv. flaccumfaciens is an important disease in terms of economic importance. It reduces grain yield by colonizing xylem vessels, subsequently impeding the translocation of water and nutrients to the superior plant parts. The existence of physiological races in C. flaccumfaciens pv. flaccumfaciens has not so far been reported. The objective of the present investigation was to identify physiological races, evaluate differential interaction, and select resistant genotypes of common bean. Initially, 30 genotypes of common bean were inoculated with eight isolates exhibiting different levels of aggressiveness, under controlled greenhouse conditions. Disease was assessed 15 days after inoculation. The existence of differential interactions between C. flaccumfaciens pv. flaccumfaciens isolates and common bean genotypes were identified by utilizing partial diallel analysis. The most aggressive isolates were BRM 14939 and BRM 14942 and the least aggressive isolates were BRM 14941 and BRM 14946. The genotypes IPA 9, Ouro Branco, and Michelite were selected as more resistant among the test isolates. The genotypes IAC Carioca Akytã, BRS Notável, Pérola, IAC Carioca Aruã, and Coquinho contributed more to the isolate x genotype interaction according to the ecovalence method of estimation, and were, therefore, indicated as differentials. Based on these results, it was possible to conclude that physiological races of the pathogen exist, to select resistant genotypes, and to propose a set of differentials.

Comparison of Clean-Up Methods for Ochratoxin A on Wine, Beer, Roasted Coffee and Chili Commercialized in Italy

PubMed Central

Prelle, Ambra; Spadaro, Davide; Denca, Aleksandra; Garibaldi, Angelo; Gullino, Maria Lodovica

2013-01-01

The most common technique used to detect ochratoxin A (OTA) in food matrices is based on extraction, clean-up, and chromatography detection. Different clean-up cartridges, such as immunoaffinity columns (IAC), molecular imprinting polymers (MIP), Mycosep™ 229, Mycospin™, and Oasis® HLB (Hydrophilic Lipophilic balance) as solid phase extraction were tested to optimize the purification for red wine, beer, roasted coffee and chili. Recovery, reproducibility, reproducibility, limit of detection (LOD) and limit of quantification (LOQ) were calculated for each clean-up method. IAC demonstrated to be suitable for OTA analysis in wine and beer with recovery rate >90%, as well as Mycosep™ for wine and chili. On the contrary, MIP columns were the most appropriate to clean up coffee. A total of 120 samples (30 wines, 30 beers, 30 roasted coffee, 30 chili) marketed in Italy were analyzed, by applying the developed clean-up methods. Twenty-seven out of 120 samples analyzed (22.7%: two wines, five beers, eight coffees, and 12 chili) resulted positive to OTA. A higher incidence of OTA was found in chili (40.0%) more than wine (6.6%), beers (16.6%) and coffee (26.6%). Moreover, OTA concentration in chili was the highest detected, reaching 47.8 µg/kg. Furthermore, three samples (2.5%), two wines and one chili, exceeded the European threshold. PMID:24152987

[Psychosocial care following the firework disaster in Enschede; the lessons from the Bijlmer airline disaster].

PubMed

Gersons, B P R; Huijsman-Rubingh, R R R; Olff, M

2004-07-17

When the psychosocial-care scheme for victims of the firework explosion in Enschede, the Netherlands (2000) was set up, lessons learned from the Bijlmer airline disaster (Amsterdam 1992) were put into practice. The aftermath of this incident showed that psychological and physical health problems can still occur many years later. The main failure of the aftercare of the Bijlmer disaster lay in the coordination of aid and the monitoring of health problems. In Enschede steps were taken to redress these problems. An information and advice centre (IAC) was set up to monitor the well-being of the victims, and to provide them with information and, where necessary, assistance. It is responsible for limiting the effects of the disaster. A total of 13,000 people have consulted the IAC. A residents' association was formed. This gave the victims a common voice during the process of attempting to restore normality in their lives. A specialized mental health-care unit was founded to treat disaster-related disorders using evidence-based treatments. So far approximately 1,300 people have consulted this body. A longitudinal study has been set up to map the consequences of the disaster and to advise aid organizations. This will also give information on the extent to which these methods have been able to limit the long-term consequences.

Transiting exoplanets from the CoRoT space mission . XIII. CoRoT-13b: a dense hot Jupiter in transit around a star with solar metallicity and super-solar lithium content

NASA Astrophysics Data System (ADS)

Cabrera, J.; Bruntt, H.; Ollivier, M.; Díaz, R. F.; Csizmadia, Sz.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carone, L.; Carpano, S.; Deleuil, M.; Deeg, H. J.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; Mazeh, T.; Moutou, C.; Ofir, A.; von Paris, P.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

2010-11-01

We announce the discovery of the transiting planet CoRoT-13b. Ground-based follow-up in CFHT and IAC80 confirmed CoRoT's observations. The mass of the planet was measured with the HARPS spectrograph and the properties of the host star were obtained analyzing HIRES spectra from the Keck telescope. It is a hot Jupiter-like planet with an orbital period of 4.04 days, 1.3 Jupiter masses, 0.9 Jupiter radii, and a density of 2.34 g cm-3. It orbits a G0V star with T_eff = 5 945 K, M* = 1.09 M⊙, R_* = 1.01 R⊙, solar metallicity, a lithium content of + 1.45 dex, and an estimated age of between 0.12 and 3.15 Gyr. The lithium abundance of the star is consistent with its effective temperature, activity level, and age range derived from the stellar analysis. The density of the planet is extreme for its mass, implies that heavy elements are present with a mass of between about 140 and 300 {M}⊕. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

34 CFR 656.1 - What is the National Resource Centers Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What is the National Resource Centers Program? 656.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies or...

34 CFR 656.1 - What is the National Resource Centers Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false What is the National Resource Centers Program? 656.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies or...

34 CFR 656.1 - What is the National Resource Centers Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the National Resource Centers Program? 656.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies or...

34 CFR 656.1 - What is the National Resource Centers Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false What is the National Resource Centers Program? 656.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies or...

34 CFR 656.1 - What is the National Resource Centers Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What is the National Resource Centers Program? 656.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies or...

The Impact of Contemporary Conflicts Between Latin American Nations on Regional Stability and Cooperation

DTIC Science & Technology

1990-02-12

of Interamerican Studies and World Affairs, Winter 88-89, pp 139-170. 20. " Bogota y Caracas Acuerdan Med iac ion, " Nuevo Heral1d (Miami), 29 March...Banco Central del Ecuador. El Ecuadur in La OPEP. Quito: Ediciones Bancentral, 1979. 8. "Bogota y Caracas Acuerdan Mediacion." Nuevo Herald (Miami...Sur. Revista Chileno de Geooolitica, Vol. 3, April 1989, pp 59-98. 69. Porse, Ernesto G. "El Conflicto de los Grandes Proyectos Hidroelectricos

Construction of New Campylobacter Cloning Vectors and a New Mutational Cat Cassette

DTIC Science & Technology

1993-01-01

mutational cat cassette PE - 61102A PR - 3M161102 6. AUTHOR(S) TA - BS13AK Yao R, Aim RA, Trust TJ, Guerry P WU- 1291 7. PERFORMING ORGANIZATION NAME(S) AND...mutational cat cassette %~ccesion For (Site-specific mutagenesis; recombinant DNA; multiple cloning site; PCR; shuttle vectors) NTIS CRA&I OTIC TAB E...campylobacter portion of these vectors, only three CAT , Cm acetyllraaseriase; car, gene encoding CAT , Cm, restriction sites in the IacZ MCS remain unique

Study to Evaluate the Safety and Tolerability of IACS-010759 in Subjects With Advanced Solid Tumors and Lymphoma

ClinicalTrials.gov

2018-05-25

Malignant Neoplasm of Breast; Malignant Neoplasms of Bone and Articular Cartilage; Malignant Neoplasms of Digestive Organs; Malignant Neoplasms of Female Genital Organs; Malignant Neoplasms of Lip Oral Cavity and Pharynx; Malignant Neoplasms of Male Genital Organs; Malignant Neoplasms of Mesothelial and Soft Tissue; Malignant Neoplasms of Respiratory and Intrathoracic Organs; Malignant Neoplasms of Thyroid and Other Endocrine Glands; Malignant Neoplasms of Urinary Tract; Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic

Optical spectroscopy of SN2014J

NASA Astrophysics Data System (ADS)

Kotak, R.

2014-01-01

Authors: J. Polshaw, R. Kotak, J. R. Maund, S. J. Smartt (QUB), M. Fraser, N. Walton (IoA), J. M. Abreu (IAC), M. Balcells, C. Benn, J. Mendez, A. Oscoz, O. Zamora, C. Zurita (ING) A spectrum of the supernova SN 2014J in the nearby galaxy M82 was obtained on Jan. 23.2 2014 (UT) at the 2.54m Isaac Newton Telescope (INT) with IDS and the grating R1200R (approximate wavelength range 5600 - 7500A, at 2A resolution).

A Comprehensive Modeling Approach Towards Understanding and Prediction of the Alaskan Coastal System Response to Changes in an Ice-diminished Arctic

DTIC Science & Technology

2009-01-01

to generate the 3 member ensembles). In total we’ve run 120 months of simulations as part of the pan-Arctic WRF evaluation. Results from the...2009: Polar atmospheric modeling in an Arctic system model, IAMAS-IAPSO-IACS MOCA-09 Joint Assembly , Montreal, Canada. Higgins, M.E. and J.J...W., and J. Clement Kinney, 2009: Oceanic Heat Contribution to Arctic Sea Ice Melt, EGU , Vienna, Austria. Maslowski, W., 2009: State of Arctic

The Coast Artillery Journal. Volume 64, Number 3, March 1926

DTIC Science & Technology

1926-03-01

Admiral William .L. Rodgers . 298 THE COAST ARTILLERY JOURNAL ANTUrBCJlAFT :\\IAcBINE Cu~u Il’f AcrJOl’f r I I EDITORIALS The Chief of Coast Artillerv ON...Jefferson and Hamilton. Therein lies the theme of this story. In our childhood histories we read extracts from the stirring speeches of Pat- rick ...made Pies a Specialty PHOEBUS, VA. FORT MONROE, ’VIRGINIA Telephone 315 Fresh Fruits and Vegetables. Everything in Season. Fresh Killed Chicken a

Simulation of Edge Effects in Electroanalytical Experiments by Orthogonal Collocation. Part I. Two Dimensional Collocation and Theory for Chronoamperometry.

DTIC Science & Technology

1982-08-18

cselixataan has been shown to Pro, imonedimie. FIN SMCS10 tam we m Vp assuma threry. In lacd. it has been shown lor difeent oide a pouwerful method to simulate...Afortd meaden 11. ’by)W~itl 116.ttousol =odimra She delade Ia~c Ul - by she Oa SWISS INaolder 10 wAce shem. re’te" s s m rnb -bute r~ 6 X-06 CSc a I

Displacement energy of the surface layers of tungsten

NASA Astrophysics Data System (ADS)

Han, Longtao; Krstic, Predrag

2015-11-01

A molecular dynamics study with BOP potential is used to calculate the threshold displacement energy (ED) of primary knock-on atoms in the surface layers of the tungsten bcc crystal lattice at 300 K and at various crystallographic directions. Depending on the direction, ED is 10% to 75% smaller from the bulk value at the first layer, interfacing vacuum, while it reaches close to the bulk value already at the third tungsten layer. Supported by IACS of SBU and LDRD of PPPL.

34 CFR 669.1 - What is the Language Resource Centers Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Language Resource Centers Program? 669.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LANGUAGE RESOURCE CENTERS PROGRAM General § 669.1 What is the Language Resource Centers Program? The Language Resource Centers Program makes awards, through grants or...

34 CFR 669.1 - What is the Language Resource Centers Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What is the Language Resource Centers Program? 669.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LANGUAGE RESOURCE CENTERS PROGRAM General § 669.1 What is the Language Resource Centers Program? The Language Resource Centers Program makes awards, through grants or...

Guidelines for cytopathologic diagnosis of epithelioid and mixed type malignant mesothelioma. Complementary statement from the International Mesothelioma Interest Group, also endorsed by the International Academy of Cytology and the Papanicolaou Society of Cytopathology

PubMed Central

Hjerpe, Anders; Ascoli, Valeria; Bedrossian, Carlos; Boon, Mathilde; Creaney, Jenette; Davidson, Ben; Dejmek, Annika; Dobra, Katalin; Fassina, Ambrogio; Field, Andrew; Firat, Pinar; Kamei, Toshiaki; Kobayashi, Tadao; Michael, Claire W.; Önder, Sevgen; Segal, Amanda; Vielh, Philippe

2015-01-01

To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma (MM). Cytopathologists involved in the International Mesothelioma Interest Group (IMIG) and the International Academy of Cytology (IAC), who have an interest in the field contributed to this update. Reference material includes peer-reviewed publications and textbooks. This article is the result of discussions during and after the IMIG 2012 conference in Boston, followed by thorough discussions during the 2013 IAC meeting in Paris. Additional contributions have been obtained from cytopathologists and scientists, who could not attend these meetings, with final discussions and input during the IMIG 2014 conference in cape town. During the previous IMIG biennial meetings, thorough discussions have resulted in published guidelines for the pathologic diagnosis of MM. However, previous recommendations have stated that the diagnosis of MM should be based on histological material only.[12] Accumulating evidence now indicates that the cytological diagnosis of MM supported by ancillary techniques is as reliable as that based on histopathology, although the sensitivity with cytology may be somewhat lower.[345] Recognizing that noninvasive diagnostic modalities benefit both the patient and the health system, future recommendations should include cytology as an accepted method for the diagnosis of this malignancy.[67] The article describes the consensus of opinions of the authors on how cytology together with ancillary testing can be used to establish a reliable diagnosis of MM. PMID:26681974

Evaluation of extraction methods for ochratoxin A detection in cocoa beans employing HPLC.

PubMed

Mishra, Rupesh K; Catanante, Gaëlle; Hayat, Akhtar; Marty, Jean-Louis

2016-01-01

Cocoa is an important ingredient for the chocolate industry and for many food products. However, it is prone to contamination by ochratoxin A (OTA), which is highly toxic and potentially carcinogenic to humans. In this work, four different extraction methods were tested and compared based on their recoveries. The best protocol was established which involves an organic solvent-free extraction method for the detection of OTA in cocoa beans using 1% sodium hydrogen carbonate (NaHCO3) in water within 30 min. The extraction method is rapid (as compared with existing methods), simple, reliable and practical to perform without complex experimental set-ups. The cocoa samples were freshly extracted and cleaned-up using immunoaffinity column (IAC) for HPLC analysis using a fluorescence detector. Under the optimised condition, the limit of detection (LOD) and limit of quantification (LOQ) for OTA were 0.62 and 1.25 ng ml(-1) respectively in standard solutions. The method could successfully quantify OTA in naturally contaminated samples. Moreover, good recoveries of OTA were obtained up to 86.5% in artificially spiked cocoa samples, with a maximum relative standard deviation (RSD) of 2.7%. The proposed extraction method could determine OTA at the level 1.5 µg kg(-)(1), which surpassed the standards set by the European Union for cocoa (2 µg kg(-1)). In addition, an efficiency comparison of IAC and molecular imprinted polymer (MIP) column was also performed and evaluated.

[Simultaneous determination of zeranols and chloramphenicol in foodstuffs of animal origin by combination immunoaffinity column clean-up and liquid chromatography-tandem mass spectrometry].

PubMed

Wang, Qing; Wang, Guomin; Xi, Cunxian; Li, Xianliang; Chen, Dongdong; Tang, Bobin; Zhang, Lei; Zhao, Hua

2014-06-01

A combination immunoaffinity column (IAC-CZ) clean-up and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytical method was successfully developed for zearalenol, beta-zearalenol and zearalenone) and chloramphenicol (CAP) in foodstuffs of animal origin. The samples (fish, liver, milk and honey) were enzymatically digested by beta-glucuronidase/sulfatase for about 16 h and then extracted with ether. The extracts were evaporated to dryness and then the residues were dissolved by 1.0 mL of 50% acetonitrile solution. After filtered and diluted with PBS buffer, the reconstituted solution were cleaned-up with a IAC-CZ and then analyzed by LC-MS/MS in multiple reaction monitoring (MRM) mode. The chromatographic separation was performed on a Shimadzu Shim-pack VP-ODS column with gradient elution by acetonitrile and 2 mmol/L ammonium acetate solution. The detection was carried out by electrospray negative ionization mass spectrometry in MRM mode. The proposed method was validated by the limit of detection (0.04-0.10 microg/kg), linearity (R2 > or = 0.999 0), average recoveries (70.9%-95.6%) and precisions (2.0% - 11.8%). The developed method is reliable, sensitive and has good applicability. The combination immunoaffinity column was proved to be an effective pretreatment technique to decrease the matrix effect, and it met the requirements of residue analysis of co-occurring zeranols and chloramphenicol.

French chemists and the international reorganisation of chemistry after World War I.

PubMed

Fauque, Danielle M E

2011-07-01

Founded in 1919, the International Union of Pure and Applied Chemistry (IUPAC) was successor to the International Association of Chemical Societies (IACS), which had been founded eight years earlier at the initiative of Albin Haller. The statutes of the IUPAC (like those of the IACS) were written in French, and it was agreed that the IUPAC's administrative headquarters should be in Paris. With these arrangements in place, the role of French chemists generally, and of Haller and Charles Moureu in particular, assumed crucial importance. In 1927, on the occasion of the centenary of Marcelin Berthelot's birth, plans were laid for an international centre for chemistry in Paris, soon to be known as the Maison de la Chimie. From the start, the Maison de la Chimie project was led by the French, most conspicuously by Jean Gérard, general secretary of the Société de chimie industrielle and of the IUPAC. Gérard's contribution to a number of national and international committees, notably for scientific documentation, left an enduring legacy. The years between 1918 and 1927, especially 1918-1919, were decisive for the rebuilding, on many fronts, of international networks embracing individuals and institutions recently separated by war. This article examines the particular case of chemistry, with reference to this wider context and to the widely shared determination to fashion an organisation that would transcend national boundaries and embrace both the pure and the applied aspects of the discipline.

Fatigue induced changes in conical implant-abutment connections.

PubMed

Blum, Kai; Wiest, Wolfram; Fella, Christian; Balles, Andreas; Dittmann, Jonas; Rack, Alexander; Maier, Dominik; Thomann, Ralf; Spies, Benedikt Christopher; Kohal, Ralf Joachim; Zabler, Simon; Nelson, Katja

2015-11-01

Based on the current lack of data and understanding of the wear behavior of dental two-piece implants, this study aims for evaluating the microgap formation and wear pattern of different implants in the course of cyclic loading. Several implant systems with different conical implant-abutment interfaces were purchased. The implants were first evaluated using synchrotron X-ray high-resolution radiography (SRX) and scanning electron microscopy (SEM). The implant-abutment assemblies were then subjected to cyclic loading at 98N and their microgap was evaluated after 100,000, 200,000 and 1 million cycles using SRX, synchrotron micro-tomography (μCT). Wear mechanisms of the implant-abutment connection (IAC) after 200,000 cycles and 1 million cycles were further characterized using SEM. All implants exhibit a microgap between the implant and abutment prior to loading. The gap size increased with cyclic loading with its changes being significantly higher within the first 200,000 cycles. Wear was seen in all implants regardless of their interface design. The wear pattern comprised adhesive wear and fretting. Wear behavior changed when a different mounting medium was used (brass vs. polymer). A micromotion of the abutment during cyclic loading can induce wear and wear particles in conical dental implant systems. This feature accompanied with the formation of a microgap at the IAC is highly relevant for the longevity of the implants. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Magnetic resonance imaging of facial nerve schwannoma.

PubMed

Thompson, Andrew L; Aviv, Richard I; Chen, Joseph M; Nedzelski, Julian M; Yuen, Heng-Wai; Fox, Allan J; Bharatha, Aditya; Bartlett, Eric S; Symons, Sean P

2009-12-01

This study characterizes the magnetic resonance (MR) appearances of facial nerve schwannoma (FNS). We hypothesize that the extent of FNS demonstrated on MR will be greater compared to prior computed tomography studies, that geniculate involvement will be most common, and that cerebellar pontine angle (CPA) and internal auditory canal (IAC) involvement will more frequently result in sensorineural hearing loss (SNHL). Retrospective study. Clinical, pathologic, and enhanced MR imaging records of 30 patients with FNS were analyzed. Morphologic characteristics and extent of segmental facial nerve involvement were documented. Median age at initial imaging was 51 years (range, 28-76 years). Pathologic confirmation was obtained in 14 patients (47%), and the diagnosis reached in the remainder by identification of a mass, thickening, and enhancement along the course of the facial nerve. All 30 lesions involved two or more contiguous segments of the facial nerve, with 28 (93%) involving three or more segments. The median segments involved per lesion was 4, mean of 3.83. Geniculate involvement was most common, in 29 patients (97%). CPA (P = .001) and IAC (P = .02) involvement was significantly related to SNHL. Seventeen patients (57%) presented with facial nerve dysfunction, manifesting in 12 patients as facial nerve weakness or paralysis, and/or in eight with involuntary movements of the facial musculature. This study highlights the morphologic heterogeneity and typical multisegment involvement of FNS. Enhanced MR is the imaging modality of choice for FNS. The neuroradiologist must accurately diagnose and characterize this lesion, and thus facilitate optimal preoperative planning and counseling.

Design, modeling and simulations of a Cabinet Safe System for a linear particle accelerator of intermediate-low energy by optimization of the beam optics

NASA Astrophysics Data System (ADS)

Maidana, Carlos Omar

As part of an accelerator based Cargo Inspection System, studies were made to develop a Cabinet Safe System by Optimization of the Beam Optics of Microwave Linear Accelerators of the IAC-Varian series working on the S-band and standing wave pi/2 mode. Measurements, modeling and simulations of the main subsystems were done and a Multiple Solenoidal System was designed. This Cabinet Safe System based on a Multiple Solenoidal System minimizes the radiation field generated by the low efficiency of the microwave accelerators by optimizing the RF waveguide system and by also trapping secondaries generated in the accelerator head. These secondaries are generated mainly due to instabilities in the exit window region and particles backscattered from the target. The electron gun was also studied and software for its right mechanical design and for its optimization was developed as well. Besides the standard design method, an optimization of the injection process is accomplished by slightly modifying the gun configuration and by placing a solenoid on the waist position while avoiding threading the cathode with the magnetic flux generated. The Multiple Solenoidal System and the electron gun optimization are the backbone of a Cabinet Safe System that could be applied not only to the 25 MeV IAC-Varian microwave accelerators but, by extension, to machines of different manufacturers as well. Thus, they constitute the main topic of this dissertation.

Resection planning for robotic acoustic neuroma surgery

NASA Astrophysics Data System (ADS)

McBrayer, Kepra L.; Wanna, George B.; Dawant, Benoit M.; Balachandran, Ramya; Labadie, Robert F.; Noble, Jack H.

2016-03-01

Acoustic neuroma surgery is a procedure in which a benign mass is removed from the Internal Auditory Canal (IAC). Currently this surgical procedure requires manual drilling of the temporal bone followed by exposure and removal of the acoustic neuroma. This procedure is physically and mentally taxing to the surgeon. Our group is working to develop an Acoustic Neuroma Surgery Robot (ANSR) to perform the initial drilling procedure. Planning the ANSR's drilling region using pre-operative CT requires expertise and around 35 minutes' time. We propose an approach for automatically producing a resection plan for the ANSR that would avoid damage to sensitive ear structures and require minimal editing by the surgeon. We first compute an atlas-based segmentation of the mastoid section of the temporal bone, refine it based on the position of anatomical landmarks, and apply a safety margin to the result to produce the automatic resection plan. In experiments with CTs from 9 subjects, our automated process resulted in a resection plan that was verified to be safe in every case. Approximately 2 minutes were required in each case for the surgeon to verify and edit the plan to permit functional access to the IAC. We measured a mean Dice coefficient of 0.99 and surface error of 0.08 mm between the final and automatically proposed plans. These preliminary results indicate that our approach is a viable method for resection planning for the ANSR and drastically reduces the surgeon's planning effort.

The Center for Aerospace Research: A NASA Center of Excellence at North Carolina Agricultural and Technical State University

NASA Technical Reports Server (NTRS)

Lai, Steven H.-Y.

1992-01-01

This report documents the efforts and outcomes of our research and educational programs at NASA-CORE in NCA&TSU. The goal of the center was to establish a quality aerospace research base and to develop an educational program to increase the participation of minority faculty and students in the areas of aerospace engineering. The major accomplishments of this center in the first year are summarized in terms of three different areas, namely, the center's research programs area, the center's educational programs area, and the center's management area. In the center's research programs area, we focus on developing capabilities needed to support the development of the aerospace plane and high speed civil transportation system technologies. In the educational programs area, we developed an aerospace engineering option program ready for university approval.

Low-cost humic acid-bonded silica as an effective solid-phase extraction sorbent for convenient determination of aflatoxins in edible oils.

PubMed

Zhou, Neng-Zhi; Liu, Ping; Su, Xiao-Chuan; Liao, Yan-Hua; Lei, Ning-Sheng; Liang, Yong-Hong; Zhou, Shao-Huan; Lin, Wen-Si; Chen, Jie; Feng, Yu-Qi; Tang, Yang

2017-06-01

Aflatoxins (AFs) are highly toxic, mutagenic, carcinogenic, and teratogenic secondary metabolites produced by the toxigenic fungi Aspergillus flavus and Aspergillus parasiticus. AFs tend to contaminate a wide range of foods which is a serious and recurring food safety problem worldwide. Currently, immunoaffinity chromatography (IAC) has become the most conventional sample clean-up method for determining AFs in foodstuffs. However, IAC method is limited in the large-scale food analysis because it requires the use of expensive disposable cartridges and the IA procedure is time-consuming. Herein, to achieve the cost-effective determination of AFs in edible oils, we developed a promising solid-phase extraction (SPE) method based on commercially available humic acid-bonded silica (HAS) sorbent, followed by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) analysis. In HAS-SPE, AFs can be captured by the HAS sorbent with both hydrophobic and hydrophilic interactions, whereas the oil matrix was captured only with the hydrophobic interactions. The oil matrix can be sufficiently washed off with isopropanol, while the AFs were still retained on the SPE packing, thus achieving selective extraction of AFs and clean-up of oil matrices. Under the optimal conditions of HAS-SPE, satisfactory recoveries ranging from 82% to 106% for four AFs (B 1 , B 2 , G 1 , and G 2 ) were achieved in various oil matrices, containing blended oil, tea oil, rapeseed oil, peanut oil, sunflower seed oil, corn oil, blended olive oil, rice oil, soybean oil, and sesame oil. Only minor matrix effects ranging from 99% to 105% for four AFs were observed. Moreover, the LODs of AFs between 0.012 and 0.035 μg/kg completely meet the regulatory levels fixed by the EU, China or other countries. The methodology was further validated for assaying the naturally contaminated peanut oils, and consistent results between the HAS-SPE and the referenced IAC were obtained. In addition, HAS-SPE can directly treat diluted oil sample without liquid-liquid extraction and is automatable, thus making it simple and convenient for the large-scale determination of AFs in edible oils. Using this method, we successfully detected four AFs in the naturally contaminated peanut oils, which is, to the best of our knowledge, the first report about the determination of AFs in edible oils using HA-based SPE. Copyright © 2017 Elsevier B.V. All rights reserved.

Ground-based follow-up in relation to Kepler asteroseismic investigation

NASA Astrophysics Data System (ADS)

Uytterhoeven, K.; Briquet, M.; Bruntt, H.; De Cat, P.; Frandsen, S.; Gutiérrez-Soto, J.; Kiss, L.; Kurtz, D. W.; Marconi, M.; Molenda-Żakowicz, J.; Østensen, R.; Randall, S.; Southworth, J.; Szabó, R.

2010-12-01

The Kepler space mission, successfully launched in March 2009, is providing continuous and high-precision photometry of thousands of stars simultaneously. The uninterrupted time-series of stars of all known pulsation types are a precious source for asteroseismic studies. The Kepler data do not provide information on the physical parameters, such as T_eff, log g, metallicity, and v sin i, which are crucial for successful asteroseismic modelling. Additional ground-based time-series data are needed to characterize mode parameters in several types of pulsating stars. Therefore, ground-based multi-colour photometry and mid/high-resolution spectroscopy are needed to complement the space data. We present ground-based activities within KASC on selected asteroseismic Kepler targets of several pulsation types. Based on observations made with the Isaac Newton Telescope and William Herschel Telescope operated by the Isaac Newton Group, with the Nordic Optical Telescope, operated jointly by Denmark, Finland, Iceland, Norway, and Sweden, with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica), and with the Mercator telescope, operated by the Flemish Community, all on the island of La Palma at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias (IAC). Based on observations made with the IAC-80 operated on the island of Tenerife by the IAC at the Spanish Observatorio del Teide. Also based on observations taken at the observatories of Sierra Nevada, San Pedro Mártir, Vienna, Xinglong, Apache Point, Lulin, Tautenburg, McDonald, Skinakas, Pic du Midi, Mauna Kea, Steward Observatory, Mt. Wilson, Białków Observatory of the Wrocław University, Piszkésteto Mountain Station, and Observatoire de Haute Provence. Based on spectra taken at the Loiano (INAF - OA Bologna), Serra La Nave (INAF - OA Catania) and Asiago (INAF - OA Padova) observatories. Also based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck-Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC). We acknowledge with thanks the variable star observations from the AAVSO International Database contributed by observers worldwide and used in this research. Funding for the Kepler mission is provided by NASA's Science Mission Directorate. We thank the entire Kepler team for the development and operations of this outstanding mission.

77 FR 37022 - Disability and Rehabilitation Research Projects and Centers Program; Rehabilitation Engineering...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

...; Rehabilitation Engineering Research Centers AGENCY: Office of Special Education and Rehabilitative Services... Rehabilitation Research Projects and Centers Program--Rehabilitation Engineering Research Centers (RERC). SUMMARY... amended (Rehabilitation Act). Rehabilitation Engineering Research Centers Program (RERCs) The purpose of...

Conference Proceedings of Defense Modeling and Simulation Office Information/Data Base Technology Working Group (I/DBTWG) Meetings Held During the Week of July 11-15, 1994

DTIC Science & Technology

1994-07-15

xi- ACKNOWLEDGMENTS The I/DBTWG co-chairs would like to thank Ms. Linda Quicker of RAND for her efforts in coordinating the I/DBTWG meeting and...Subgroup on Authoritative Data Sources: Mr. Bill Dunn 0930-0945 Report from M&S Complex Data Task Force Subgroup on Categorization: Mr. Len Seligman ...issues; and need to address maintenance of the Authoritative Data Source directory by DMSO/IAC. - 15- Mr. Len Seligman : Report from M&S Complex Data Tasm

Fort Wayne, Baer Field, Indiana. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-02-01

51 ~A~EAC0-9-5 COL A) PREVIOUIS EDITION$ OF THIS FORM ARE CaSOLETE. i- -AL CLIMATOLO;jY BRANCH SKY COVER .r’AT&H SERVICL/’IAC 33 FT wAY.E I4 7 -8 NCV ...Tomlefmtwe 564. 6186 6574 883 6.7 720 sOP . , Dry 5Uwb 2369483 40821 56*7 8.754 720 91 1403 2o3 90 ;I Web Eub 2213376 958 54 23 720 ,3 1094 9| 90 Do P oint

Integrated analysis of large space systems

NASA Technical Reports Server (NTRS)

Young, J. P.

1980-01-01

Based on the belief that actual flight hardware development of large space systems will necessitate a formalized method of integrating the various engineering discipline analyses, an efficient highly user oriented software system capable of performing interdisciplinary design analyses with tolerable solution turnaround time is planned Specific analysis capability goals were set forth with initial emphasis given to sequential and quasi-static thermal/structural analysis and fully coupled structural/control system analysis. Subsequently, the IAC would be expanded to include a fully coupled thermal/structural/control system, electromagnetic radiation, and optical performance analyses.

Operational Information Sharing: Working to Bring the Benefits of the Net-Centric Data Strategy to the Warfighter

DTIC Science & Technology

2009-03-01

participating in exercises with PACOM  and NORTHCOM. During these  exercises, on‐site personnel from DTIC  were able to reach back into the  scientific ... collections  and IACs, and pull  together and synthesize information for  the missions.  Feedback from the exercises confirmed  the value of the

A Comprehensive Modeling Approach Towards Understanding and Prediction of the Alaskan Coastal System Response to Changes in an Ice-diminished Arctic

DTIC Science & Technology

2009-09-30

and 28 day spin-up times used to generate the 3 member ensembles). In total we’ve run 120 months of simulations as part of the pan-Arctic WRF...Cassano, J.J. and M.W. Seefeldt, 2009: Polar atmospheric modeling in an Arctic system model, IAMAS-IAPSO-IACS MOCA-09 Joint Assembly , Montreal, Canada...NOAA, Seattle, WA. Maslowski, W., and J. Clement Kinney, 2009: Oceanic Heat Contribution to Arctic Sea Ice Melt, EGU , Vienna, Austria. Maslowski, W

Modular System Control Development Model (MSCDM). Design Specification.

DTIC Science & Technology

1979-08-01

with power supply and ¶ can be used independently of the loop. The PDU can be used as a general purpose processor. The loop is contained in a separate...inputs to nodes 22 (VSQC), 23 (DSQC ) , and 26 (BWBSA) will be generated by a LSI—ll microprocessor used as a simulated input generator (SIG). The SIG...who c o b m n u n i — cate tau lt - s to the FIAC module. F~IAC generates even t reports to the OCRI and DBMS. The PDP1I/40 in loop 2 generates

The General Aviation Dynamics Model Volume III. Systems Manual.

DTIC Science & Technology

1979-07-01

SEXi and SEX2 or in some other way, as desired by the user. The descriptors of an index are used as stubs (row descriptors) and/or spanners (column...BAR A produces the following plot [7 SUWPLO~TS DATASET A, 1970 TO 1975 8+ .QL xx YXXMX 4+ MXUXX IDLMXX XXXXXX * yyx :mx0(c XXX *m XXXX XX XXXXX XMxK...VXXXCK 2+ mm~ XXXXX MMXXX I~CUM LXXMXx *X2~ XXX xXX =uXX ImXXXLMX * xx Iac lxxno IXxc= )LccIQX * XX= )LXXX ILMKXX X.XXXX IXXCX SHOW

THE ROTATION PERIOD OF C/2014 Q2 (LOVEJOY)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Serra-Ricart, Miquel; Licandro, Javier, E-mail: mserra@iac.es, E-mail: jlicandr@iac.es

2015-11-20

C/2014 Q2 (Lovejoy) was observed around perihelion (2015 January 30) on 15 nights between 2015 January 21 and February 11 using the TADer 0.3-m astrograph telescope at Teide Observatory (IAC, Tenerife, Spain). Two large spiral jet structures were observed over several cometary rotations. A new method of searching for periodicities in the PA of spiral jets in the coma region at a fixed distance (20,624 km) from the cometary optocenter is presented and used to determine a nuclear rotation period of 17.89 ± 0.17 hr.

Developing a Blueprint for Successful Private Partnership Programs in Small Fusion Centers: Key Program Components and Smart Practices

DTIC Science & Technology

2013-03-01

The Baseline Capabilities for State and Major Urban Area Fusion Centers required fusion centers to establish programs to interact with the private...sector. These programs took the form of Public and Private Sector outreach programs. This requirement had a profound budgetary and operational impact on...fusion centers, but agencies received very little guidance about how to plan, organize, and sustain these programs. The goal of this thesis was to

The Environmental protection agency industrial technology transfer program

NASA Technical Reports Server (NTRS)

Suter, K. H.

1974-01-01

Today TAC consists of a full service information center and five programs, which are: (1) our industrial program; (2) the energy information center; (3) the business and industry extension program; (4) the remote sensing program; and (5) the center for environmental research and development.

45 CFR 1306.32 - Center-based program option.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Center-based program option. 1306.32 Section 1306... START PROGRAM HEAD START STAFFING REQUIREMENTS AND PROGRAM OPTIONS Head Start Program Options § 1306.32 Center-based program option. (a) Class size. (1) Head Start classes must be staffed by a teacher and an...

Meeting the Public Health Challenge of Pain in Later Life: What Role Can Senior Centers Play?

PubMed Central

Tobias, Karen R.; Lama, Sonam D.; Parker, Samantha J.; Henderson, Charles R.; Nickerson, Allison J.; Reid, M.C.

2013-01-01

Background Interest in nonpharmacologic approaches for managing pain continues to grow. Aim To determine the types of pain-relevant programs offered by senior centers and whether the programs varied by clients' race/ethnicity status and center size. Design and methods We conducted a telephone survey. Respondents were presented with a list of 15 programs (plus other) and asked: (1) whether the activity was offered and if so how often; (2) if they believed the programs had value for seniors with pain; and (3) whether the classes were advertised as a means of achieving pain relief. Setting New York City. Participants/Subjects Senior center agency staff, i.e., center directors, activity program coordinators. Results Of 204 center staff contacted, 195 (95.6%) participated. The most common programs offered were movement-based, including exercise (by 91.8% of the centers), dance (72.3%), walking clubs (71.8%), yoga (65.6%), and Tai Chi (53.3%) classes. Creative arts programs were also frequently offered, including music (58.5%) and fine arts (47.7%). Programs such as stress management (27%) and relaxation (26%) classes were less commonly offered. Most respondents identified movement-based programs as helpful for seniors with pain, while few identified creative arts classes as potentially beneficial. The programs/classes offered were infrequently advertised as a means of helping seniors manage pain, and varied by clients' race/ethnicity status and center size. Conclusion Programs that have potential utility for older adults with pain are commonly offered by senior centers. Future research should determine optimal strategies for engaging older adults in these programs in the senior center setting. PMID:24144569

76 FR 37085 - Applications for New Awards; Rehabilitation Engineering Research Centers (RERCs)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... DEPARTMENT OF EDUCATION Applications for New Awards; Rehabilitation Engineering Research Centers...)--Disability and Rehabilitation Research Projects and Centers Program--Rehabilitation Engineering Research... (Rehabilitation Act). Rehabilitation Engineering Research Centers Program (RERCs) The purpose of the RERC program...

Design and synthesis of target-responsive aptamer-cross-linked hydrogel for visual quantitative detection of ochratoxin A.

PubMed

Liu, Rudi; Huang, Yishun; Ma, Yanli; Jia, Shasha; Gao, Mingxuan; Li, Jiuxing; Zhang, Huimin; Xu, Dunming; Wu, Min; Chen, Yan; Zhu, Zhi; Yang, Chaoyong

2015-04-01

A target-responsive aptamer-cross-linked hydrogel was designed and synthesized for portable and visual quantitative detection of the toxin Ochratoxin A (OTA), which occurs in food and beverages. The hydrogel network forms by hybridization between one designed DNA strand containing the OTA aptamer and two complementary DNA strands grafting on linear polyacrylamide chains. Upon the introduction of OTA, the aptamer binds with OTA, leading to the dissociation of the hydrogel, followed by release of the preloaded gold nanoparticles (AuNPs), which can be observed by the naked eye. To enable sensitive visual and quantitative detection, we encapsulated Au@Pt core-shell nanoparticles (Au@PtNPs) in the hydrogel to generate quantitative readout in a volumetric bar-chart chip (V-Chip). In the V-Chip, Au@PtNPs catalyzes the oxidation of H2O2 to generate O2, which induces movement of an ink bar to a concentration-dependent distance for visual quantitative readout. Furthermore, to improve the detection limit in complex real samples, we introduced an immunoaffinity column (IAC) of OTA to enrich OTA from beer. After the enrichment, as low as 1.27 nM (0.51 ppb) OTA can be detected by the V-Chip, which satisfies the test requirement (2.0 ppb) by the European Commission. The integration of a target-responsive hydrogel with portable enrichment by IAC, as well as signal amplification and quantitative readout by a simple microfluidic device, offers a new method for portable detection of food safety hazard toxin OTA.

[Adherence to pharmaceutical guidance in patients over 85 years of age with chronic heart failure-stage C. Effects on 12-month mortality].

PubMed

Esteve Arríen, Ainhoa; Domínguez de Pablos, Gema; Minaya Saiz, Jesús

2009-01-01

To describe factors related to prescription on discharge of treatment for Chronic Heart Failure(CHF)-Stage C and to analyse whether this is related to 12month-mortality. Observational follow-up study of patients over 85 hospitalized during 2006/7 with Stage C-Chronic Heart Failure in an outskirt support hospital. Drug-prescription adherence was assessed according to the American Heart Society 2005-Guidelines and recommendations of the American Geriatrics Society-2007. A multivariate analysis of logistic regression was performed to obtain odds for 12-month mortality for each recommended therapy, adjusting by mortality risk factors. 104 patients aged 90+/-3yr were followed on discharge, 85% of which were women. NYHA-classes were distributed NYHA I-28,2%, II-37,9%, III-30,1%, IV-3,9%. Most frequently prescribed drugs were loop diuretics (83,3%) and IACEs/ARB (62%), and the less frequent beta-blockers (19,1%). IACEs/ARB were prescribed to those with lower functional impairment (p=0.04), and beta-blockers to those with worse NYHA class (p=0.02). All recommended prescriptions had a tendency to 12 month mortality risk reduction, even adjusted by age, functional status, co-morbidity, NYHA class and co-morbid atrial fibrillation, except for spironolactone (OR-1,8; IC95% 0,48-17,19). Treatment with CHF disease-modifying therapies except for spironolactone can reduce 12 month risk mortality, also in the oldest old. There exists room for improvement in frequency of drug prescription in this group of age.

Compression Properties and Electrical Conductivity of In-Situ 20 vol.% Nano-Sized TiCx/Cu Composites with Different Particle Size and Morphology

PubMed Central

Zhang, Dongdong; Bai, Fang; Sun, Liping; Wang, Yong; Wang, Jinguo

2017-01-01

The compression properties and electrical conductivity of in-situ 20 vol.% nano-sized TiCx/Cu composites fabricated via combustion synthesis and hot press in Cu-Ti-CNTs system at various particles size and morphology were investigated. Cubic-TiCx/Cu composite had higher ultimate compression strength (σUCS), yield strength (σ0.2), and electric conductivity, compared with those of spherical-TiCx/Cu composite. The σUCS, σ0.2, and electrical conductivity of cubic-TiCx/Cu composite increased by 4.37%, 20.7%, and 17.8% compared with those of spherical-TiCx/Cu composite (526 MPa, 183 MPa, and 55.6% International Annealed Copper Standard, IACS). Spherical-TiCx/Cu composite with average particle size of ~94 nm exhibited higher ultimate compression strength, yield strength, and electrical conductivity compared with those of spherical-TiCx/Cu composite with 46 nm in size. The σUCS, σ0.2, and electrical conductivity of spherical-TiCx/Cu composite with average size of ~94 nm in size increased by 17.8%, 33.9%, and 62.5% compared with those of spherical-TiCx/Cu composite (417 MPa, 121 MPa, and 40.3% IACS) with particle size of 49 nm, respectively. Cubic-shaped TiCx particles with sharp corners and edges led to stress/strain localization, which enhanced the compression strength of the composites. The agglomeration of spherical-TiCx particles with small size led to the compression strength reduction of the composites. PMID:28772859

NASA's engineering research centers and interdisciplinary education

NASA Technical Reports Server (NTRS)

Johnston, Gordon I.

1990-01-01

A new program of interactive education between NASA and the academic community aims to improve research and education, provide long-term, stable funding, and support cross-disciplinary and multi-disciplinary research. The mission of NASA's Office of Aeronautics, Exploration and Technology (OAET) is discussed and it is pointed out that the OAET conducts about 10 percent of its total R&D program at U.S. universities. Other NASA university-based programs are listed including the Office of Commercial Programs Centers for the Commercial Development of Space (CCDS) and the National Space Grant program. The importance of university space engineering centers and the selection of the nine current centers are discussed. A detailed composite description is provided of the University Space Engineering Research Centers. Other specialized centers are described such as the Center for Space Construction, the Mars Mission Research Center, and the Center for Intelligent Robotic Systems for Space Exploration. Approaches to educational outreach are discussed.

78 FR 47419 - Requirements for the OSHA Training Institute Education Centers Program and the OSHA Outreach...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

...] Requirements for the OSHA Training Institute Education Centers Program and the OSHA Outreach Training Program... approval of the information collection requirements contained in the OSHA Training Institute Education... Educational Programs, or Kimberly Mason, OSHA Training Institute Education Centers Program at the address...

34 CFR 415.1 - What is the Demonstration Centers for the Training of Dislocated Workers Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... CENTERS FOR THE TRAINING OF DISLOCATED WORKERS PROGRAM General § 415.1 What is the Demonstration Centers for the Training of Dislocated Workers Program? The Demonstration Centers for the Training of... 34 Education 3 2011-07-01 2011-07-01 false What is the Demonstration Centers for the Training of...

34 CFR 415.1 - What is the Demonstration Centers for the Training of Dislocated Workers Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... CENTERS FOR THE TRAINING OF DISLOCATED WORKERS PROGRAM General § 415.1 What is the Demonstration Centers for the Training of Dislocated Workers Program? The Demonstration Centers for the Training of... 34 Education 3 2010-07-01 2010-07-01 false What is the Demonstration Centers for the Training of...

Implementation of a tobacco-free workplace program at a local mental health authority.

PubMed

Correa-Fernández, Virmarie; Wilson, William T; Shedrick, Deborah A; Kyburz, Bryce; L Samaha, Hannah; Stacey, Timothy; Williams, Teresa; Lam, Cho Y; Reitzel, Lorraine R

2017-06-01

Tobacco-free workplace policies that incorporate evidence-based practices can increase the reach and effectiveness of tobacco dependence treatment among underserved populations but may be underutilized due to limited knowledge about implementation processes. This paper describes the implementation of a comprehensive tobacco-free workplace program at a behavioral healthcare community center in Texas. The center participated in a tobacco-free workplace program implementation project that provided guidance and resources and allowed center autonomy in implementation. Six employee-based subcommittees guided implementation of program components including consumer and staff surveys, policy development, signage, tobacco use assessments, communication, and nicotine replacement distribution. Timeline development, successes, challenges, lessons learned, and sustainability initiatives are delineated. Concerns about the tobacco-free workplace policy from the center's staff and consumers were gradually replaced by strong support for the initiative. Program success was enabled by consistent support from the center's leadership, publicity of program efforts, and educational campaigns. The center surpassed the program expectations when it adopted a tobacco-free hiring policy, which was not an initial program goal. This center's path to a tobacco-free workplace provides an implementation and sustainability model for other behavioral health community centers and other organizations to become tobacco free.

Nurse-midwives in federally funded health centers: understanding federal program requirements and benefits.

PubMed

Carter, Martha

2012-01-01

Midwives are working in federally funded health centers in increasing numbers. Health centers provide primary and preventive health care to almost 20 million people and are located in every US state and territory. While health centers serve the entire community, they also serve as a safety net for low-income and uninsured individuals. In 2010, 93% of health center patients had incomes below 200% of the Federal Poverty Guidelines, and 38% were uninsured. Health centers, including community health centers, migrant health centers, health care for the homeless programs, and public housing primary care programs, receive grant funding and enjoy other benefits due to status as federal grantees and designation as federally qualified health centers. Clinicians working in health centers are also eligible for financial and professional benefits because of their willingness to serve vulnerable populations and work in underserved areas. Midwives, midwifery students, and faculty working in, or interacting with, health centers need to be aware of the regulations that health centers must comply with in order to qualify for and maintain federal funding. This article provides an overview of health center regulations and policies affecting midwives, including health center program requirements, scope of project policy, provider credentialing and privileging, Federal Tort Claims Act malpractice coverage, the 340B Drug Pricing Program, and National Health Service Corps scholarship and loan repayment programs. © 2012 by the American College of Nurse-Midwives.

The Space Puppets

NASA Astrophysics Data System (ADS)

Lago, M. Miguel; Esteban Berea, J.; Miñambres Fernández, M.; Rufino, M.

2002-01-01

This proposal is a response to the initiative "Physics on Stage 2" to excite interest in physics and science by a dance and puppetry performance. The purpose of this piece is to show the possibilities and characteristics of entertainment with space knowledge and education for the audience of teachers and children through a show. Two virtually opposite areas (science and arts), both generally inaccessible for children, will be introduced in a funny and amusing way, with the interaction of puppets. Education is not "fashion"... we need to develop an educational package to focus the attention of children on the uses of Space in everyday life. Our world today is mainly logic and mathematical. The presence of art in the children's lives is often scarce or even inexistent. With the performance children will gain a better understanding of space physics through the joy of a dance performance like an educational tool. Dance as body expression, is a very powerful tool to explain and interact with children and teachers. Through dance the physics of movement may be studied in a visual way, within the body's limits. We consider as priority the use of dance as well as theater (in this case, puppet theater) as an efficient and fun didactic method, which we may go further and explain in an imaginative funny way all those complex processes of physics, which are further unknown. Aiming to teach in a relaxing atmosphere the performance is based on the " Earth Space Alphabet", a first dictionary for Primary Schools combining Science, Space and Education... Did you ever realize that people are not interested in something because they do not understand the words or the meaning? The alphabet is intended to meet the overwhelming need that exists for education on space, and allows both teachers and children to learn about the "Art of Teaching Space" combining earth and space language linked by space technology. The performance explains many concepts of physics through a comet puppet, which travels in Space driving the dance artist on its tail. On the journey, they discover the alphabet letters, letters that make words, words which are concepts of physics, physics which is on the stage this stage being space. The teacher before, during and after the performance, will analyse, review and discuss through this simple tool "an alphabet", space vocabulary and also the meaning of communication and teaching. They will relate to the present situation of physics and science education in general and Space in particular and how to address this problem through our language. Instructions Name of Conference to which this abstract is53rd IAC submitted FirstFirst Submission Subrnission/Update/Correction/Withdrawal Title of Contribution in plain ASCII.The Space Puppets Author(s): a) Last Name, Initial(s) - b) LastMIGUEL LAGO., M. Name, lnitial(s) - c) etc. Number and Title or Abbreviation of SessionP. Space and Education Symposium to which this abstract is submitted.P.3. Educational and Outreach Name of Chairs of that SessionFrank Friedlaender and Dennis Stone Indicate any equipment you need in addition to the standard equipment: One overhead projector and screen will be available in ail IAC sessions. A limited number of LCD and 35mm slide projectors will be provided in sessions based on advance notice of need and availability of projectors. All presenters should bring copies of their computer presentations in overhead format in case LCD projection is not available for a specific session. Type of abstract file added/attached/sentWord file sent by e-mail separately Address of Main Author:Miguel Lago NameMónica. First Name Dept. Company/University: PO Box/Street:P.O. Box ZIP Code:D-22415 City: Country: Telephone: E-mail:+31 71 565 36 84 E-mail:+31 71 565 55 90 Have you obtained or will you obtain approval to attend the Congress? Yes Are you willing to present this paper at the IAC Public Outreach Program: Yes

Novel Problem Solving - The NASA Solution Mechanism Guide

NASA Technical Reports Server (NTRS)

Keeton, Kathryn E.; Richard, Elizabeth E.; Davis, Jeffrey R.

2014-01-01

Over the past five years, the Human Health and Performance (HH&P) Directorate at the NASA Johnson Space Center (JSC) has conducted a number of pilot and ongoing projects in collaboration and open innovation. These projects involved the use of novel open innovation competitions that sought solutions from "the crowd", non-traditional problem solvers. The projects expanded to include virtual collaboration centers such as the NASA Human Health and Performance Center (NHHPC) and more recently a collaborative research project between NASA and the National Science Foundation (NSF). These novel problem-solving tools produced effective results and the HH&P wanted to capture the knowledge from these new tools, to teach the results to the directorate, and to implement new project management tools and coursework. The need to capture and teach the results of these novel problem solving tools, the HH&P decided to create a web-based tool to capture best practices and case studies, to teach novice users how to use new problem solving tools and to change project management training/. This web-based tool was developed with a small, multi-disciplinary group and named the Solution Mechanism Guide (SMG). An alpha version was developed that was tested against several sessions of user groups to get feedback on the SMG and determine a future course for development. The feedback was very positive and the HH&P decided to move to the beta-phase of development. To develop the web-based tool, the HH&P utilized the NASA Tournament Lab (NTL) to develop the software with TopCoder under an existing contract. In this way, the HH&P is using one new tool (the NTL and TopCoder) to develop the next generation tool, the SMG. The beta-phase of the SMG is planed for release in the spring of 2014 and results of the beta-phase testing will be available for the IAC meeting in September. The SMG is intended to disrupt the way problem solvers and project managers approach problem solving and to increase the use of novel and more cost and time effective problem solving tools such as open innovation, collaborative research, and virtual collaborative project centers. The HH&P envisions changing project management coursework by including the SMG in the teaching of project management problem solving tools.

NASA as a Convener: Government, Academic and Industry Collaborations Through the NASA Human Health and Performance Center

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.; Richard, Elizabeth E.

2011-01-01

On October 18, 2010, the NASA Human Health and Performance center (NHHPC) was opened to enable collaboration among government, academic and industry members. Membership rapidly grew to 60 members (http://nhhpc.nasa.gov ) and members began identifying collaborative projects as detailed below. In addition, a first workshop in open collaboration and innovation was conducted on January 19, 2011 by the NHHPC resulting in additional challenges and projects for further development. This first workshop was a result of the SLSD successes in running open innovation challenges over the past two years. In 2008, the NASA Johnson Space Center, Space Life Sciences Directorate (SLSD) began pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical problems. From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external challenges were conducted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive platform, customized to NASA use, and promoted as NASA@Work. The results from the 34 challenges involved not only technical solutions that were reported previously at the 61st IAC, but also the formation of new collaborative relationships. For example, the TopCoder pilot was expanded by the NASA Space Operations Mission Directorate to the NASA Tournament Lab in collaboration with Harvard Business School and TopCoder. Building on these initial successes, the NHHPC workshop in January of 2011, and ongoing NHHPC member discussions, several important collaborations are in development: Space Act Agreement between NASA and GE for collaborative projects, NASA and academia for a Visual Impairment / Intracranial Hypertension summit (February 2011), NASA and the DoD through the Defense Venture Catalyst Initiative (DeVenCI) for a technical needs workshop (June 2011), NASA and the San Diego Zoo in Biomimicry, NASA and the FAA Center of Excellence for Commercial Space Flight for collaborative projects, NASA and the FDA concerning automatic external defibrillators, and NASA and Tufts University for an education pilot. These and other collaborations will be detailed in the paper demonstrating that a government-sponsored convening entity (the NHHPC) can facilitate industry, academic, and non-profit collaborations for products of mutual benefit.

Advancing Innovation Through Collaboration: Implementation of the NASA Space Life Sciences Strategy

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.; Richard, Elizabeth E.

2010-01-01

On October 18, 2010, the NASA Human Health and Performance center (NHHPC) was opened to enable collaboration among government, academic and industry members. Membership rapidly grew to 90 members (http://nhhpc.nasa.gov ) and members began identifying collaborative projects as detailed in this article. In addition, a first workshop in open collaboration and innovation was conducted on January 19, 2011 by the NHHPC resulting in additional challenges and projects for further development. This first workshop was a result of the SLSD successes in running open innovation challenges over the past two years. In 2008, the NASA Johnson Space Center, Space Life Sciences Directorate (SLSD) began pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical problems. From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external challenges were conducted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive platform, customized to NASA use, and promoted as NASA@Work. The results from the 34 challenges involved not only technical solutions that were reported previously at the 61st IAC, but also the formation of new collaborative relationships. For example, the TopCoder pilot was expanded by the NASA Space Operations Mission Directorate to the NASA Tournament Lab in collaboration with Harvard Business School and TopCoder. Building on these initial successes, the NHHPC workshop in January of 2011, and ongoing NHHPC member discussions, several important collaborations have been developed: (1) Space Act Agreement between NASA and GE for collaborative projects (2) NASA and academia for a Visual Impairment / Intracranial Hypertension summit (February 2011) (3) NASA and the DoD through the Defense Venture Catalyst Initiative (DeVenCI) for a technical needs workshop (June 2011) (4) NASA and the San Diego Zoo for a joint challenge in biomimicry (5) NASA and the FAA Center of Excellence for Commercial Space Flight for five collaborative projects (6) NASA and ESA for a Space Medicine Workshop (July 2011) (7) NASA and Tufts University for an education pilot (8) Establishment of long-term contracts (August 2011) to enable future challenges (9) Establishment of a new Center of Excellence for Collaborative Innovation (July 2011) for all federal agencies in the US

76 FR 27648 - World Trade Center (WTC) Health Program Scientific/Technical Advisory Committee; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade... Prevention (CDC), announces the establishment of the World Trade Center (WTC) Health Program Scientific..., Designated Federal Officer, World Trade Center Health Program Scientific/Technical Advisory Committee...

75 FR 29366 - ``Homeless Veterans' Reintegration Program (HVRP) National Technical Assistance Center...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-25

... ``Homeless Veterans' Reintegration Program (HVRP) National Technical Assistance Center Cooperative Agreement...). Section 2021 authorizes programs to expedite the reintegration of homeless Veterans into the labor force... Technical Assistance Center (NTAC) for the Homeless Veterans' Reintegration Program (HVRP) to include the...

7 CFR 226.17 - Child care center provisions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false Child care center provisions. 226.17 Section 226.17... AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.17 Child care center provisions. (a) Child care centers may participate in the Program either as independent...

7 CFR 226.17 - Child care center provisions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 4 2014-01-01 2014-01-01 false Child care center provisions. 226.17 Section 226.17... AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.17 Child care center provisions. (a) Child care centers may participate in the Program either as independent...

7 CFR 226.17 - Child care center provisions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Child care center provisions. 226.17 Section 226.17... AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.17 Child care center provisions. (a) Child care centers may participate in the Program either as independent...

78 FR 38983 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP-STAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP-STAC) Correction: This notice was... and Control, (BSC, NCIPC) and the name of the Committee should read World Trade Center Health Program...

Hazard Assessment Computer System HACS/UIM Users’ Operation Manual. Volume II.

DTIC Science & Technology

1981-09-01

AMMONIUM OXALATE FAS FERROUS AMMONIUM SULFATE FCL FERRIC CHLORIDE FCP FERRIC GLYCEROPHOSPHATE FEC FERROUS CHLORIDE FFA FURFURAL FFB FERROUS FLUOROBORATE...FAL FFA FFBi FMA FNS FSA FSL FXX BAK GAT SAY SCM GCR GCS SOC SOS SPL SRF GSR STA J-2 HAC HAI HAL HEIR HCC HCL HCN HDC HE’S HDZ HFA HFX HMD HMI HPA...ENP EOEI EOP EOT EPC ETA ETC ETD ETf3 ETI FAL FFA FFB FMA FMS VSL OCR GOS GIA MAC HAI HCL Ht’Z HFA HMD HMI HPA HPdkt HPO HSS HXG IAA IAC IAL IAN IBR

Assessing the Impact of Development Disruptions and Dependencies in System of Systems

DTIC Science & Technology

2017-02-24

time  situational   awareness .  The  Analytical Workbench’s combination of dependency metrics (strength, criticality, and impact) will  be leveraged...IAC 2016 “Understanding Human Space Exploration” 67th IAF International Astronautical Congress Guadalajara, Mexico, 26‐30 Sept 2016...demonstrated use  of  internal  simulation  based  data  being  used  in  tandem  with  SODA  toolset  for  interdependency analysis.    NASA Marshall  Space

[Immunoaffinity columns and determination of ochratoxin A in cereals by HPLC. Part I.: Evaluation of extraction using methanol/water].

PubMed

Czerwiecki, Ludwik; Czyzyk, Kamila; Kwiecień, Agnieszka; Wilczyńska, Grazyna

2004-01-01

The method for ochratoxin A determination in cereals (wheat, rye) was described. Application of immunoaffinity columns (IAC) for clean-up of extracts was investigated. The ochratoxin A content was determined by high-performance liquid chromatography using C18 column and fluorimetric detection at 330 nm (excitation) and 460 nm (emission). The mean recovery of ochratoxin A was 65-78%. The limits of detection (LOD) and quantification (LOQ) were 0.015 and 0.025 microg/kg, respectively. The positive results were confirmed by reaction with BF3 complex in methanol.

Correlation of Federal Test Method Standard 791B Method 354 with Army 240-Hour Tracked Vehicle Test Cycle Method 355T.

DTIC Science & Technology

1983-09-30

8217i APPENDICES AYA -17 " %%%’. % % - ’ ’. ,’ ,, ".: ’ #’.’ . ’. - ; . . ., ’ .* " ’ ., . . - %- % ’w APPENDIX A V)% =5 C) C) C,) = D - ) IacF C-) C.D LL...unless so designated by other authorized documents. Trade names cited in this report do not constitute an official endorsement or appro- .*e val of the...UNIT NUMBERS Southwest Research Institute San Antonio, TX 78284 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE 4. U.S. Army Belvoir R& D

Review of the Fire Control System.

DTIC Science & Technology

1980-11-18

TIE FIRE CONTROL SYSTEM Final Report;, CDRL #A005 a weaa . 1 VItdbu!i A UaR11.d Gy 8.Ic.80 12 05 028 W Unclassified. Uf e C’ L V A’ N ON -A iAC’ , 14 n...ta FI..Ie d) REPORT DOCUMENTATON PAREAD INSTRU-TION. PR--PAGE FRE COMPLETING FORM W 4E,’ 1 - " r ’ i:!VBE i 2 GOVT ACESSION NO. 3 RECIPIENT’S...enhancements of old applications. (continued on next page) DD 1 FAM , 1473 E ITON OF I NOV 65IS OBSOLETES.IN 0102-LF.014-6601 Unclassified SECUAITY

Tc-labeling of Peptidomimetic Antagonist to Selectively Target alpha(v)beta(3) Receptor-Positive Tumor: Comparison of PDA and EDDA as co-Ligands.

PubMed

Shin, In Soo; Maeng, Jin Soo; Jang, Beom-Su; You, Eric; Cheng, Kenneth; Li, King C P; Wood, Bradford; Carrasquillo, Jorge A; Danthi, S Narasimhan; Paik, Chang H

2010-01-01

OBJECTIVES: The aim of this research was to synthesize radiolabeled peptidomimetic integrin alpha(v)beta(3) antagonist with (99m)Tc for rapid targeting of integrin alpha(v)beta(3) receptors in tumor to produce a high tumor to background ratio. METHODS: The amino terminus of 4-[2-(3,4,5,6-tetra-hydropyrimidin-2-ylamino)-ethyloxy]benzoyl-2-(S)-[N-(3-amino-neopenta-1-carbamyl)]-aminoethylsulfonyl-amino-beta-alanine hydrochloride (IAC) was conjugated with N-hydroxysuccinimide ester of HYNIC and labeled with (99m)Tc using tricine with either 1,5-pyridinedicarboxylic acid (PDA) or ethylenediamine-N,N'-diacetic acid (EDDA) as the co-ligand. The products, (99m)Tc EDDA(2)/HYNIC-IAC (P1) and (99m)Tc PDA (tricin)/HYNIC-IAC (P2) were subjected to in vitro serum stability, receptor-binding, biodistribution and imaging studies. RESULTS: P1 and P2 were synthesized with an overall yield of >80%. P1 was slightly more stable than P2 when incubated in serum at 37 degrees C for 18 hrs (84 vs 77% intact). The In vitro receptor-binding of P1 was higher than that of P2 (78.02 +/- 13.48 vs 51.05 +/- 14.05%) when incubated with alpha(v)beta(3) at a molar excess (0.8 muM). This receptor binding was completely blocked by a molar excess of an unlabeled peptidomimetic antagonist. Their differences shown in serum stability and the receptor-binding appeared to be related to their biological behaviors in tumor uptake and retention; the 1 h tumor uptakes of P1 and P2 were 3.17+/-0.52 and 2.13+/-0.17 % ID/g, respectively. P1 was retained in the tumor longer than P2. P1 was excreted primarily through the renal system whereas P2 complex was excreted equally via both renal and hepatobiliary systems. Thus, P1 was retained in the whole-body with 27.25 +/- 3.67% ID at 4 h whereas 54.04 +/- 3.57% ID of P2 remained in the whole-body at 4 h. This higher whole-body retention of P2 appeared to be resulted from a higher amount of radioactivity retained in liver and intestine. These findings were supported by imaging studies showing higher tumor-to-abdominal contrast for P1 than for P2 at 3 h postinjection. CONCLUSIONS: P1 showed good tumor targeting properties with a rapid tumor uptake, prolonged tumor retention and fast whole-body clearance kinetics. These findings warrant further investigation of the HYNIC method of (99m)Tc labeling of other peptidomimetic antagonists using EDDA as a coligand.

Trends in HIV Terminology: Text Mining and Data Visualization Assessment of International AIDS Conference Abstracts Over 25 Years

PubMed Central

2018-01-01

Background The language encompassing health conditions can also influence behaviors that affect health outcomes. Few published quantitative studies have been conducted that evaluate HIV-related terminology changes over time. To expand this research, this study included an analysis of a dataset of abstracts presented at the International AIDS Conference (IAC) from 1989 to 2014. These abstracts reflect the global response to HIV over 25 years. Two powerful methodologies were used to evaluate the dataset: text mining to convert the unstructured information into structured data for analysis and data visualization to represent the data visually to assess trends. Objective The purpose of this project was to evaluate the evolving use of HIV-related language in abstracts presented at the IAC from 1989 to 2014. Methods Over 80,000 abstracts were obtained from the International AIDS Society and imported into a Microsoft SQL Server database for data processing and text mining analyses. A text mining module within the KNIME Analytics Platform, an open source software, was then used to mine the partially processed data to create a terminology corpus of key HIV terms. Subject matter experts grouped the terms into categories. Tableau, a data visualization software, was used to visualize the frequency metrics associated with the terms as line graphs and word clouds. The visualized dashboards were reviewed to discern changes in terminology use across IAC years. Results The major findings identify trends in HIV-related terminology over 25 years. The term “AIDS epidemic” was dominantly used from 1989 to 1991 and then declined in use. In contrast, use of the term “HIV epidemic” increased through 2014. Beginning in the mid-1990s, the term “treatment experienced” appeared with increasing frequency in the abstracts. Use of terms identifying individuals as “carriers or victims” of HIV rarely appeared after 2008. Use of the terms “HIV positive” and “HIV infected” peaked in the early-1990s and then declined in use. The terms “men who have sex with men” and “MSM” were rarely used until 1994; subsequently, use of these terms increased through 2014. The term “sex worker” steadily increased in frequency throughout conference years, whereas the term “prostitute” decreased over time. Conclusions The results of this study highlight changes in HIV terminology use over 25 years, including the addition, disappearance, and changing use of terms that reflect advances in HIV research and medical practice and destigmatization of the disease. Coupled with findings from related quantitative research, HIV-related terminology recommendations based on results of this study are included. Adoption of these recommendations will further efforts to use less stigmatizing language and facilitate effective communication between health professionals and people affected by HIV. PMID:29728344

Educational Applications of Astronomy & Space Flight Operations at the Kennedy Space Center

NASA Astrophysics Data System (ADS)

Erickson, L. K.

1999-09-01

Within two years, the Kennedy Space Center will complete a total redesign of NASA's busiest Visitor's Center. Three million visitors per year will be witness to a new program focused on expanding the interests of the younger public in NASA's major space programs, in space operations, and in astronomy. This project, being developed through the Visitor's Center director, a NASA faculty fellow, and the Visitor's Center contractor, is centered on the interaction between NASA programs, the visiting youth, and their parents. The goal of the Center's program is to provide an appealing learning experience for teens and pre teens using stimulating displays and interactive exhibits that are also educational.

Inference of genetic diversity in popcorn S3 progenies.

PubMed

Pena, G F; do Amaral, A T; Ribeiro, R M; Ramos, H C C; Boechat, M S B; Santos, J S; Mafra, G S; Kamphorst, S H; de Lima, V J; Vivas, M; de Souza Filho, G A

2016-05-09

Molecular markers are a useful tool for identification of complementary heterotic groups in breeding programs aimed at the production of superior hybrids, particularly for crops such as popcorn in which heterotic groups are not well-defined. The objective of the present study was to analyze the genetic diversity of 47 genotypes of tropical popcorn to identify possible heterotic groups for the development of superior hybrids. Four genotypes of high genetic value were studied: hybrid IAC 125, strain P2, and varieties UENF 14 and BRS Angela. In addition, 43 endogamous S3 progenies obtained from variety UENF 14 were used. Twenty-five polymorphic SSR-EST markers were analyzed. A genetic distance matrix was obtained and the following molecular diversity parameters were estimated: number of alleles, number of effective alleles, polymorphism information content (PIC), observed and expected heterozygosities, Shannon diversity index, and coefficient of inbreeding. We found a moderate PIC and high diversity index, indicating that the studied population presents both good discriminatory ability and high informativeness for the utilized markers. The dendrogram built based on the dissimilarity matrix indicated six distinct groups. Our findings demonstrate the genetic diversity among the evaluated genotypes and provide evidence for heterotic groups in popcorn. Furthermore, the functional genetic diversity indicates that there are informative genetic markers for popcorn.

[Health behaviors between a health promotion demonstration health center and a general health center].

PubMed

Lee, Taewha; Lee, Chung-Yul; Kim, Hee-Soon; Ham, Ok-Kyung

2005-06-01

The purpose of the study was to compare community residents' perceptions, participation, satisfaction, and behavioral changes between a health promotion demonstration health center and general health center. The design of the study was ex-post facto that compared community residents in demonstration health centers and general health centers. The sample included 2,261 community residents who were conveniently selected from demonstration (792 participants) and general health centers (1,496 participants). The results of the study were as follows: 1) Perception and participation rates of exercise, nutrition, and hypertension management programs were significantly higher in the participants of demonstration health centers than those of general health centers.; 2) Satisfaction rates of all programs except the smoking cessation program were significantly higher in the participants of demonstration health centers than those of general health centers. However, only the exercise rate among risk behaviors of participants was significantly higher in demonstration health centers than general health centers. Systematic efforts for health promotion were effective not only in improving the community's awareness, participation, and satisfaction of the program, but also in changing health behaviors. This evidence should be used to foster and disseminate health promotion programs to other health centers to improve community residents' health status and quality of life.

Developing a Family-Centered, Hospital-Based Perinatal Education Program

PubMed Central

Westmoreland, Marcia Haskins; Zwelling, Elaine

2000-01-01

The development of a family-centered, comprehensive perinatal education program for a large, urban hospital system is described. This program was developed in conjunction with the building of a new women's center and, although the authors were fortunate that several opportunities for educational program development were linked to this project, many of the steps taken and the lessons learned can be helpful to anyone desiring to develop a similar program. This article relates perinatal education to the principles of family-centered maternity care, outlines the criteria for a quality educational program, gives rationale for this type of program development, and offers practical suggestions for starting or enhancing a perinatal education program within a hospital system. PMID:17273228

Small Business Administration Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

...: 3245-AF99 Private Loan Disaster Program 284 Women's Business Center Program 3245-AG02 285 Interest Rate...: 202 205-7728 Email: [email protected] RIN: 3245-AF99 284. WOMEN'S BUSINESS CENTER PROGRAM Legal Authority: 15 USC 656 Abstract: SBA plans to issue regulations for the Women's Business Center (WBC) Program...

Western Mountain Initiative - Research Links

Science.gov Websites

Parks programS Forest Service Climate Change Resource Center (CCRC) North American Nitrogen Center to be told." US Global Change Research Program (GlobalChange.gov) USGS Climate and Land Use Rocky Mountain Science Center Global Change Research Program -- A Focus on Mountain Ecosystems Western

7 CFR 226.19a - Adult day care center provisions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false Adult day care center provisions. 226.19a Section 226..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.19a Adult day care center provisions. (a) Adult day care centers may participate in the Program...

7 CFR 226.19a - Adult day care center provisions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Adult day care center provisions. 226.19a Section 226..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.19a Adult day care center provisions. (a) Adult day care centers may participate in the Program...

7 CFR 226.19a - Adult day care center provisions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 4 2014-01-01 2014-01-01 false Adult day care center provisions. 226.19a Section 226..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM Operational Provisions § 226.19a Adult day care center provisions. (a) Adult day care centers may participate in the Program...

45 CFR 1306.32 - Center-based program option.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Center-based program option. 1306.32 Section 1306... annually for each child enrolled in a center-based program option. These visits must be initiated and... give individual attention to children entering and leaving the center. (d) Full day variation. (1) A...

45 CFR 1306.32 - Center-based program option.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Center-based program option. 1306.32 Section 1306... annually for each child enrolled in a center-based program option. These visits must be initiated and... give individual attention to children entering and leaving the center. (d) Full day variation. (1) A...

45 CFR 1306.32 - Center-based program option.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Center-based program option. 1306.32 Section 1306... annually for each child enrolled in a center-based program option. These visits must be initiated and... give individual attention to children entering and leaving the center. (d) Full day variation. (1) A...

Use a Building Learning Center Enrichment Program to Meet Needs of Gifted/Talented.

ERIC Educational Resources Information Center

Schurr, Sandra

The paper describes the Learning Center Enrichment Program for elementary school gifted and talented children. The nomenclature associated with the program model (learning center, enrichment, and management system) is defined; and it is explained that the program is organized according to the enrichment triad model advocated by J. Renzulli because…

Women's Center Volunteer Intern Program: Building Community While Advancing Social and Gender Justice

ERIC Educational Resources Information Center

Murray, Margaret A.; Vlasnik, Amber L.

2015-01-01

This program description explores the purpose, structure, activities, and outcomes of the volunteer intern program at the Wright State University Women's Center. Designed to create meaningful, hands-on learning experiences for students and to advance the center's mission, the volunteer intern program builds community while advancing social and…

IN² Program Validates Data Center Cooling Solution | News | NREL

Science.gov Websites

IN2 Program Validates Data Center Cooling Solution February 21, 2018 IN2 Program Validates Data Center Cooling Solution NREL researchers and LiquidCool Solutions representatives stand along-side centers on average consuming an estimated 70 billion kWh per year, a disruptive energy-saving solution is

USAF/SCEEE Graduate Student Summer Support Program (1982). Management and Technical Report.

DTIC Science & Technology

1982-10-01

AD-A130 767 USAF/SCEEE GRADUATE STUDENT SUMMER SUPPORT PROGRAM (1982) MANAGEMENT AND..(U) SOUTHEASTERN CENTER FORELECTRICAL ENGINEERING EDUCATION INC...SUMMER SUPPORT PROGRAM Conducted by Southeastern Center for Electrical Engineering Education under USAF Contract Number F49620-82-C-0035 MANAGEMENT ...UNITED STATES AIR FORCE GRADUATE STUDENT SL24MER SUPPORT PROGRAM 1982 PROGRAM MANAGEMENT AND TECHNICAL REPORT SOUTHEASTERN CENTER FOR ELECTRICAL

Wellness at work. Boost wellness center participation with target marketing strategies.

PubMed

DeMoranville, C W; Schoenbachler, D D; Przytulski, J

1998-01-01

By using target marketing strategies, corporate wellness programs can increase employee participation rates and tailor activities to meet employee needs. The authors examined this issue through a research survey that segmented a university's staff and employee population into three wellness program groups: High Participators, Moderate Participators, and Low Participators. Participators' views on the following issues were analyzed: health management programs, exercise programs, wellness center use inhibitors, wellness center use incentives, wellness center communications, and willingness to pay for the wellness center. The results identified unique lifestyle characteristics for each group that can help make target marketing strategies effective.

78 FR 42788 - School-Based Health Center Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration School-Based Health Center Program AGENCY: Health Resources and Services Administration (HRSA), Department of Health... Gadsden County. SUMMARY: HRSA will be transferring a School-Based Health Center Capital (SBHCC) Program...

A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods.

PubMed

Greening, David W; Xu, Rong; Ji, Hong; Tauro, Bow J; Simpson, Richard J

2015-01-01

Exosomes are 40-150 nm extracellular vesicles that are released from a multitude of cell types, and perform diverse cellular functions including intercellular communication, antigen presentation, and transfer of tumorigenic proteins, mRNA and miRNA. Exosomes are important regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest their importance for diagnostic and therapeutic applications, and as drug delivery vehicles. Exosomes have been purified from biological fluids and in vitro cell cultures using a variety of strategies and techniques. In this chapter, we reveal the protocol and key insights into the isolation, purification and characterization of exosomes, distinct from shed microvesicles and apoptotic blebs. Using the colorectal cancer cell line LIM1863 as a cell model, a comprehensive evaluation of exosome isolation methods including ultracentrifugation (UC-Exos), OptiPrep™ density-based separation (DG-Exos), and immunoaffinity capture using anti-EpCAM-coated magnetic beads (IAC-Exos) were examined. All exosome isolation methodologies contained 40-150 nm vesicles based on electron microscopy, and positive for exosome markers (Alix, TSG101, HSP70) based on immunoblotting. This protocol employed a proteomic profiling approach to characterize the protein composition of exosomes, and label-free spectral counting to evaluate the effectiveness of each method in exosome isolation. Based on the number of MS/MS spectra identified for exosome markers and proteins associated with their biogenesis, trafficking, and release, IAC-Exos was shown to be the most effective method to isolate exosomes. However, the use of density-based separation (DG-Exos) provides significant advantages for exosome isolation when the use of immunoaffinity capture is limited (due to antibody availability and suitability of exosome markers).

Experimental optimization of the number of blocks by means of algorithms parameterized by confidence interval in popcorn breeding.

PubMed

Paula, T O M; Marinho, C D; Amaral Júnior, A T; Peternelli, L A; Gonçalves, L S A

2013-06-27

The objective of this study was to determine the optimal number of repetitions to be used in competition trials of popcorn traits related to production and quality, including grain yield and expansion capacity. The experiments were conducted in 3 environments representative of the north and northwest regions of the State of Rio de Janeiro with 10 Brazilian genotypes of popcorn, consisting by 4 commercial hybrids (IAC 112, IAC 125, Zélia, and Jade), 4 improved varieties (BRS Ângela, UFVM-2 Barão de Viçosa, Beija-flor, and Viçosa) and 2 experimental populations (UNB2U-C3 and UNB2U-C4). The experimental design utilized was a randomized complete block design with 7 repetitions. The Bootstrap method was employed to obtain samples of all of the possible combinations within the 7 blocks. Subsequently, the confidence intervals of the parameters of interest were calculated for all simulated data sets. The optimal number of repetition for all of the traits was considered when all of the estimates of the parameters in question were encountered within the confidence interval. The estimates of the number of repetitions varied according to the parameter estimated, variable evaluated, and environment cultivated, ranging from 2 to 7. It is believed that only the expansion capacity traits in the Colégio Agrícola environment (for residual variance and coefficient of variation), and number of ears per plot, in the Itaocara environment (for coefficient of variation) needed 7 repetitions to fall within the confidence interval. Thus, for the 3 studies conducted, we can conclude that 6 repetitions are optimal for obtaining high experimental precision.

CSER 98-003: Criticality safety evaluation report for PFP glovebox HC-21A with button can opening

DOE Office of Scientific and Technical Information (OSTI.GOV)

ERICKSON, D.G.

1999-02-23

Glovebox HC-21A is an enclosure where cans containing plutonium metal buttons or other plutonium bearing materials are prepared for thermal stabilization in the muffle furnaces. The Inert Atmosphere Confinement (IAC), a new feature added to Glovebox HC-21A, allows the opening of containers suspected of containing hydrided plutonium metal. The argon atmosphere in the IAC prevents an adverse reaction between oxygen and the hydride. The hydride is then stabilized in a controlled manner to prevent glovebox over pressurization. After removal from the containers, the plutonium metal buttons or plutonium bearing materials will be placed into muffle furnace boats and then bemore » sent to one of the muffle furnace gloveboxes for stabilization. The materials allowed to be brought into GloveboxHC-21 A are limited to those with a hydrogen to fissile atom ratio (H/X) {le} 20. Glovebox HC-21A is classified as a DRY glovebox, meaning it has no internal liquid lines, and no free liquids or solutions are allowed to be introduced. The double contingency principle states that designs shall incorporate sufficient factors of safety to require at least two unlikely, independent, and concurrent changes in process conditions before a criticality accident is possible. This criticality safety evaluation report (CSER) shows that the operations to be performed in this glovebox are safe from a criticality standpoint. No single identified event that causes criticality controls to be lost exceeded the criticality safety limit of k{sub eff} = 0.95. Therefore, this CSER meets the requirements for a criticality analysis contained in the Hanford Site Nuclear Criticality Safety Manual, HNF-PRO-334, and meets the double contingency principle.« less

[Management of occult malformations at the lateral skull base].

PubMed

Bryson, E; Draf, W; Hofmann, E; Bockmühl, U

2005-12-01

Occult malformations of the lateral skull base are rare anomalies, but can cause severe complications such as recurrent meningitis. Therefore, they need to be precisely delineated and sufficient surgical closure is mandatory. Between 1986 and 2004 twenty patients (10 children and 10 adults) with occult malformations at the lateral skull base were treated surgically at the ENT-Department of the Hospital Fulda gAG. Of these 3 Mondini-malformations, 11 defects of the tegmen tympani or the mastoidal roof, 2 dural lesions to the posterior fossa and 4 malformations within the pyramidal apex have been found. Four patients have had multiple anomalies. Routing symptom was in all cases at least one previous meningitis. Radiological diagnostics included high-resolution computed tomography (CT) and magnetic resonance imaging (MRI) as well as CT- or MR-cisternography. Depending on type and localisation of the defect the following surgical algorithm was carried out: The trans-mastoidal approach was used in all cases of Mondini-malformation (including obliteration of the ear), in case of lesions to the posterior fossa as well as partly in anomalies at the tegmen tympani and mastoidal roof, respectively. Defects of the pyramidal apex should be explored via the trans-mastoidal way if the lesion is located caudally to the inner auditory canal (IAC), whereas the trans-temporal approach should be used if the lesion is situated ventral to the IAC and dorso-medially to the internal carotid artery (ICA). The trans-temporal approach was also performed in large defects of the tegmen tympani and mastoidal roof as well as in recurrences. In all cases of recurrent meningitis caused by agents of the upper airway tract the basic principle should be to search for occult skull base malformations radiologically as well as by sodium fluorescein endoscopy as long as the anomaly is detected.

Lifetime of MCP-PMTs and other performance features

NASA Astrophysics Data System (ADS)

Lehmann, A.; Böhm, M.; Eyrich, W.; Miehling, D.; Pfaffinger, M.; Stelter, S.; Uhlig, F.; Ali, A.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kreutzfeld, K.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

2018-02-01

The bar PANDA experiment at FAIR will use DIRC detectors for the separation of hadrons. The compactness of the bar PANDA detector requires the image planes of these detectors to be placed inside the magnetic field of the solenoid. Due to this and other boundary conditions MCP-PMTs were identified as the only suitable photon sensors. Until recently the major obstacle for an application of MCP-PMTs in high rate experiments like bar PANDA were serious aging problems which led to damage at the photo-cathode and a fast declining quantum efficiency as the integrated anode charge (IAC) increased. With new countermeasures against the aging, in particular due to the application of an atomic layer deposition (ALD) technique to coat the MCP pores, the lifetime of MCP-PMTs has meanwhile increased by a factor >50 which is fully sufficient for bar PANDA. The recent results of our long-term lifetime measurements are discussed. New 2-inch MCP-PMT prototypes from Hamamatsu show an encouraging behavior. However, the currently best performing MCP-PMT is a 2-inch PHOTONIS tube with two ALD-layers which reaches an IAC of >16 C/cm2 without any visible sign of aging. In the second part of these proceedings a new data acquisition system of the PADIWA/TRB type is presented which allows a quasi-parallel measurement of many MCP-PMT performance parameters. Especially unwanted effects like dark-count rate, crosstalk, ion after-pulsing, and recoil electrons can be studied in more detail than ever before. Exemplary results for these parameters are shown. The discussed DAQ system will be used for the comprehensive data quality checks of the MCP-PMTs being built into the DIRCs.

Cosmic Magnetic Fields

NASA Astrophysics Data System (ADS)

Sánchez Almeida, J.; Martínez González, M. J.

2018-05-01

Magnetic fields play an important role in many astrophysical processes. They are difficult to detect and characterize since often their properties have to be inferred through interpreting the polarization of the light. Magnetic fields are also challenging to model and understand. Magnetized plasmas behave following highly non-linear differential equations having no general solution, so that every astrophysical problem represents a special case to be studied independently. Hence, magnetic fields are often an inconvenient subject which is overlooked or simply neglected (the elephant in the room, as they are dubbed in poster of the school). Such difficulty burdens the research on magnetic fields, which has evolved to become a very technical subject, with many small disconnected communities studying specific aspects and details. The school tried to amend the situation by providing a unifying view of the subject. The students had a chance to understand the behavior of magnetic fields in all astrophysical contexts, from cosmology to the Sun, and from starbursts to AGNs. The school was planed to present a balanced yet complete review of our knowledge, with excursions into the unknown to point out present and future lines of research. The subject of Cosmic Magnetic Fields was split into seven different topics: cosmic magnetic field essentials, solar magnetic fields, stellar magnetic fields, the role of magnetic fields on AGN feedback, magnetic fields in galaxies, magnetic fields in galaxy clusters and at larger scales, and primordial magnetic fields and magnetic fields in the early Universe. The corresponding lectures were delivered by seven well known and experienced scientists that have played key roles in the major advances of the field during the last years: F. Cattaneo, P. Judge, O. Kochukhov, R. Keppens, R. Beck, K. Dolag, and F. Finelli. Their lectures were recorded and are freely available at the IAC website: http://iactalks.iac.es/talks/serie/19.

Auditory changes in acromegaly.

PubMed

Tabur, S; Korkmaz, H; Baysal, E; Hatipoglu, E; Aytac, I; Akarsu, E

2017-06-01

The aim of this study is to determine the changes involving auditory system in cases with acromegaly. Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA. Additionally, previously performed paranasal sinus-computed tomography of all cases with acromegaly and control subjects were obtained to measure the length of internal acoustic canal (IAC). PTA values were higher (p < 0.001 for right ears and p = 0.001 for left ears), and SD scores were (p = 0.002 for right ears and p = 0.002 for left ears) lower in acromegalic patients. IAC width in acromegaly group was narrower compared to that in control group (p = 0.03 for right ears and p = 0.02 for left ears). When only cases with acromegaly were taken into consideration, PTA values in left ears had positive correlation with growth hormone and insulin-like growth factor-1 levels (r = 0.4, p = 0.02 and r = 0.3, p = 0.03). Of all cases with acromegaly 13 (32%) had hearing loss in at least one ear, 7 (54%) had sensorineural type and 6 (46%) had conductive type hearing loss. Acromegaly may cause certain changes in the auditory system in cases with acromegaly. The changes in the auditory system may be multifactorial causing both conductive and sensorioneural defects.

The impact of indoor air quality and contaminants on respiratory health of older people living in long-term care residences in Porto.

PubMed

Mendes, Ana; Papoila, Ana Luísa; Carreiro-Martins, Pedro; Bonassi, Stefano; Caires, Iolanda; Palmeiro, Teresa; Aguiar, Lívia; Pereira, Cristiana; Neves, Paula; Mendes, Diana; Botelho, Maria Amália Silveira; Neuparth, Nuno; Teixeira, João Paulo

2016-01-01

persons who are 65 years or older often spend an important part of their lives indoors thus adverse indoor climate might influence their health status. to evaluate the influence of indoor air quality and contaminants on older people's respiratory health. cross-sectional study. 21 long-term care residences (LTC) in the city of Porto, Portugal. older people living in LTC with ≥65 years old. the Portuguese version of BOLD questionnaire was administered by an interviewer to older residents able to participate (n = 143). Indoor air contaminants (IAC) were measured twice, during winter and summer in 135 areas. Mixed effects logistic regression models were used to study the association between the health questionnaire results and the monitored IAC, adjusted for age, smoking habits, gender and number of years living in the LTC. cough (23%) and sputum (12%) were the major respiratory symptoms, and allergic rhinitis (22%) the main self-reported illness. Overall particulate matter up to 2.5 micrometres in size median concentration was above the reference levels both in winter and summer seasons. Peak values of particulate matter up to 10 micrometres in size (PM10), total volatile organic compounds, carbon dioxide, bacteria and fungi exceeded the reference levels. Older people exposed to PM10 above the reference levels demonstrated higher odds of allergic rhinitis (OR = 2.9, 95% CI: 1.1-7.2). high levels of PM10 were associated with 3-fold odds of allergic rhinitis. No association was found between indoor air chemical and biological contaminants and respiratory symptoms. © The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The International Alcohol Control (IAC) study-evaluating the impact of alcohol policies.

PubMed

Casswell, Sally; Meier, Petra; MacKintosh, Anne M; Brown, Abraham; Hastings, Gerard; Thamarangsi, Thaksaphon; Chaiyasong, Surasak; Chun, Sungsoo; Huckle, Taisia; Wall, Martin; You, Ru Q

2012-08-01

This paper describes a new multicountry collaborative project to assess the impact of alcohol control policy. Longitudinal surveys of drinkers in a number of participating countries and analysis of the policy context allow for the assessment of change over time within countries and comparison between countries. The design of the study is modeled on the International Tobacco Control study and aims to assess the impact of alcohol policies in different cultural contexts on policy-related behaviors and alcohol consumption. A survey instrument and protocol for policy analysis have been developed by the initial participating countries: England, Scotland, Thailand, South Korea, and New Zealand. The first round of data collection is scheduled for 2011-2012. The survey instrument (International Alcohol Control [IAC] survey) measures key policy relevant behaviors: place and time of purchase, amounts purchased and price paid; ease of access to alcohol purchase; alcohol marketing measures; social supply; perceptions of alcohol affordability and availability and salience of price; perceptions of enforcement; people's experiences with specific alcohol restrictions; support for policy and consumption (typical quantity, frequency using beverage and location-specific measures). The Policy Analysis Protocol (PoLAP) assesses relevant aspects of the policy environment including regulation and implementation. It has proved feasible to design instruments to collect detailed data on behaviors relevant to alcohol policy change and to assess the policy environment in different cultural settings. In a policy arena in which the interest groups and stakeholders have different perceptions of appropriate policy responses to alcohol-related harm, a robust methodology to assess the impact of policy will contribute to the debate. Copyright © 2012 by the Research Society on Alcoholism.

Analytical Performance of a Multiplex Real-Time PCR Assay Using TaqMan Probes for Quantification of Trypanosoma cruzi Satellite DNA in Blood Samples

PubMed Central

Abate, Teresa; Cayo, Nelly M.; Parrado, Rudy; Bello, Zoraida Diaz; Velazquez, Elsa; Muñoz-Calderon, Arturo; Juiz, Natalia A.; Basile, Joaquín; Garcia, Lineth; Riarte, Adelina; Nasser, Julio R.; Ocampo, Susana B.; Yadon, Zaida E.; Torrico, Faustino; de Noya, Belkisyole Alarcón; Ribeiro, Isabela; Schijman, Alejandro G.

2013-01-01

Background The analytical validation of sensitive, accurate and standardized Real-Time PCR methods for Trypanosoma cruzi quantification is crucial to provide a reliable laboratory tool for diagnosis of recent infections as well as for monitoring treatment efficacy. Methods/Principal Findings We have standardized and validated a multiplex Real-Time quantitative PCR assay (qPCR) based on TaqMan technology, aiming to quantify T. cruzi satellite DNA as well as an internal amplification control (IAC) in a single-tube reaction. IAC amplification allows rule out false negative PCR results due to inhibitory substances or loss of DNA during sample processing. The assay has a limit of detection (LOD) of 0.70 parasite equivalents/mL and a limit of quantification (LOQ) of 1.53 parasite equivalents/mL starting from non-boiled Guanidine EDTA blood spiked with T. cruzi CL-Brener stock. The method was evaluated with blood samples collected from Chagas disease patients experiencing different clinical stages and epidemiological scenarios: 1- Sixteen Venezuelan patients from an outbreak of oral transmission, 2- Sixty three Bolivian patients suffering chronic Chagas disease, 3- Thirty four Argentinean cases with chronic Chagas disease, 4- Twenty seven newborns to seropositive mothers, 5- A seronegative receptor who got infected after transplantation with a cadaveric kidney explanted from an infected subject. Conclusions/Significance The performing parameters of this assay encourage its application to early assessment of T. cruzi infection in cases in which serological methods are not informative, such as recent infections by oral contamination or congenital transmission or after transplantation with organs from seropositive donors, as well as for monitoring Chagas disease patients under etiological treatment. PMID:23350002

Development of a Multiplex Real-Time PCR Assay with an Internal Amplification Control for the Detection of Total and Pathogenic Vibrio parahaemolyticus Bacteria in Oysters▿

PubMed Central

Nordstrom, Jessica L.; Vickery, Michael C. L.; Blackstone, George M.; Murray, Shelley L.; DePaola, Angelo

2007-01-01

Vibrio parahaemolyticus is an estuarine bacterium that is the leading cause of shellfish-associated cases of bacterial gastroenteritis in the United States. Our laboratory developed a real-time multiplex PCR assay for the simultaneous detection of the thermolabile hemolysin (tlh), thermostable direct hemolysin (tdh), and thermostable-related hemolysin (trh) genes of V. parahaemolyticus. The tlh gene is a species-specific marker, while the tdh and trh genes are pathogenicity markers. An internal amplification control (IAC) was incorporated to ensure PCR integrity and eliminate false-negative reporting. The assay was tested for specificity against >150 strains representing eight bacterial species. Only V. parahaemolyticus strains possessing the appropriate target genes generated a fluorescent signal, except for a late tdh signal generated by three strains of V. hollisae. The multiplex assay detected <10 CFU/reaction of pathogenic V. parahaemolyticus in the presence of >104 CFU/reaction of total V. parahaemolyticus bacteria. The real-time PCR assay was utilized with a most-probable-number format, and its results were compared to standard V. parahaemolyticus isolation methodology during an environmental survey of Alaskan oysters. The IAC was occasionally inhibited by the oyster matrix, and this usually corresponded to negative results for V. parahaemolyticus targets. V. parahaemolyticus tlh, tdh, and trh were detected in 44, 44, and 52% of the oyster samples, respectively. V. parahaemolyticus was isolated from 33% of the samples, and tdh+ and trh+ strains were isolated from 19 and 26%, respectively. These results demonstrate the utility of the real-time PCR assay in environmental surveys and its possible application to outbreak investigations for the detection of total and pathogenic V. parahaemolyticus. PMID:17644647

Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women.

PubMed

Hallund, J; Bügel, S; Tholstrup, T; Ferrari, M; Talbot, D; Hall, W L; Reimann, M; Williams, C M; Wiinberg, N

2006-06-01

Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50 mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial compliance (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period. NMD was 13.4 (SEM 2.0)% at baseline and 15.5 (SEM 1.1) % after isoflavone treatment compared with 12.4 (SEM 1.0)% after placebo treatment (P=0.03). NOx increased from 27.7 (SEM 2.7) to 31.1 (SEM 3.2) microM after isoflavones treatment compared with 25.4 (SEM 1.5) to 20.4 (SEM 1.1) microM after placebo treatment (P=0.003) and a significant increase in the NOx:ET-1 ratio (P=0.005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0.04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50 mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.

Factors Influencing Expression of Antixenosis in Soybean to Anticarsia gemmatalis and Spodoptera frugiperda (Lepidoptera: Noctuidae).

PubMed

Boiça Júnior, Arlindo Leal; De Souza, Bruno Henrique Sardinha; Costa, Eduardo Neves; Ribeiro, Zulene Antonio; Stout, Michael Joseph

2015-02-01

This study aimed to evaluate some factors that influence the expression of antixenosis in soybean genotypes against Anticarsia gemmatalis Hübner and Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae). Free-choice and no-choice feeding assays were performed with the resistant soybean genotype IAC 100 and the susceptible genotype BRSGO 8360 using A. gemmatalis and S. frugiperda larvae. The following factors that may affect expression of resistance were evaluated: one larva versus two larvae per leaf disc; use of larvae without prior feeding suspension versus larvae starved for 3 h prior to the assay; leaf discs versus entire leaflets; upper part versus lower part of the plant; and, vegetative versus reproductive growth stages. The level of resistance exhibited by the genotype IAC 100 was high enough to not be obscured by the effects of all factors assayed in the present study upon the feeding preference of A. gemmatalis and S. frugiperda larvae. However, our results demonstrate the importance of knowing the optimal conditions for conducting an assay for evaluating resistance of genotypes for specialist and generalist insect species. Utilization of two larvae of A. gemmatalis per leaf disc, not starved before the assays, with leaf discs from the upper part of plants at the reproductive growth stage provided better discrimination of differences in antixenosis expression in soybean genotypes. For S. frugiperda, use of one larva per leaf disc, not starved before the assays, with leaf discs from the lower part of plants at the reproductive growth stage gave more satisfactory results for feeding preference tests. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

EMIR, the NIR MOS and Imager for the GTC

NASA Astrophysics Data System (ADS)

Garzón, F.; EMIR Team

2016-10-01

EMIR is one of the first common-user instruments for the GTC, the 10-meter telescope operating at the Roque de los Muchachos Observatory (La Palma, Canary Islands, Spain). EMIR is being built by a Consortium of Spanish and French institutes led by the Instituto de Astrofísica de Canarias (IAC). EMIR is primarily designed to be operated as a MOS in the near-IR band, but offers a wide range of observing modes, including imaging and spectroscopy, both long slit and multi-object, in the wavelength range 0.9 to 2.5 μm. This contribution reports on the results achieved so far during the verification phase at the IAC prior to the shipment of the instrument to the GTC for being commissioned, which is due by mid 2015. EMIR is equipped with a set of three dispersive elements, one for each of the atmospheric windows J,H & K, formed by the combination of a high quality transmission grating embedded in between of two large prisms of ZnSe; plus a low resolution standard replicated grism, functional in the HK and ZJ windows in first and second dispersion orders respectively. The multi-object capability is achieved by means of the Cold Slit Unit (CSU), a cryogenic robotic reconfigurable multi-slit mask system capable of making user specified patterns with 55 different slitlets distributed across the EMIR focal plane. We will describe the principal units and features of the EMIR instrument and the main results of the verification performed so far with special emphasis on the NIR MOS capabilities. The development and fabrication of EMIR is funded by GRANTECAN and the Plan Nacional de Astronomía y Astrofísica (National Plan for Astronomy and Astrophysics, Spain).

Ames Fitness Program

NASA Technical Reports Server (NTRS)

Pratt, Randy

1993-01-01

The Ames Fitness Program services 5,000 civil servants and contractors working at Ames Research Center. A 3,000 square foot fitness center, equipped with cardiovascular machines, weight training machines, and free weight equipment is on site. Thirty exercise classes are held each week at the Center. A weight loss program is offered, including individual exercise prescriptions, fitness testing, and organized monthly runs. The Fitness Center is staffed by one full-time program coordinator and 15 hours per week of part-time help. Membership is available to all employees at Ames at no charge, and there are no fees for participation in any of the program activities. Prior to using the Center, employees must obtain a physical examination and complete a membership package. Funding for the Ames Fitness Program was in jeopardy in December 1992; however, the employees circulated a petition in support of the program and collected more than 1500 signatures in only three days. Funding has been approved through October 1993.

Meeting the public health challenge of pain in later life: what role can senior centers play?

PubMed

Tobias, Karen R; Lama, Sonam D; Parker, Samantha J; Henderson, Charles R; Nickerson, Allison J; Reid, M Carrington

2014-12-01

Interest in nonpharmacologic approaches for managing pain continues to grow. The aim of this study was to determine the types of pain-relevant programs offered by senior centers and whether the programs varied by clients' race/ethnicity status and center size. A telephone survey was conducted. Respondents were presented with a list of 15 programs and the option to choose "other" and asked (1) whether the activity was offered and, if so, how often; (2) if they believed the programs had value for seniors with pain; and (3) whether the classes were advertised as a means of achieving pain relief. Of 204 center staff contacted, 195 (95.6%) participated. The most common programs offered were movement-based, including exercise (by 91.8% of the centers), dance (72.3%), walking clubs (71.8%), yoga (65.6%), and Tai Chi (53.3%) classes. Creative arts programs were also frequently offered, including music (58.5%) and fine arts (47.7%). Programs such as stress management (27%) and relaxation (26%) classes were less commonly offered. Most respondents identified movement-based programs as helpful for seniors with pain, but few identified creative arts classes as potentially beneficial. The programs/classes offered were infrequently advertised as a means of helping seniors manage pain and varied by clients' race/ethnicity status and center size. Programs that have potential utility for older adults with pain are commonly offered by senior centers. Future research should determine optimal strategies for engaging older adults in these programs in the senior center setting. Copyright © 2014 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

Nationwide survey of cancer center programs in Korea

PubMed Central

Kim, Ji-Youn; Yi, Eun-Surk

2017-01-01

This study was conducted to investigate cancer centers established for the purpose of satisfying various needs about cancer, improving the cancer treatment environment, and subdividing services ranging from diagnosis, treatment, and rehabilitation to palliative care. To this end, the authors have surveyed programs in 17 cancer centers representing Korea, including 12 national cancer centers and five major hospitals. As a result, it was found that the most common type of lecture program was disease management, followed by health care and hospitalization, while the most common type of participation program was psychological relief, followed by physical activity. The most frequently operated type of program was found to be psychological relief, followed by physical activity and health care in the regional cancer centers, while the most frequently operated type was disease management, followed by psychological relief and health care in the five major hospitals. The proportion of physical activity was very high in two regional cancer centers, whereas five regional cancer centers did not offer physical activity programs at all. In the five major hospitals, physical activity programs were conducted regularly at least once a month or at least once a week. In addition, further studies are required to provide professional and detailed medical services for the establishment and operation of programs for cancer patient management and the environmental aspects of the hospital. PMID:28702441

Comprehensive Family-Centered Training Programs: Five Comparative Case Studies. Evaluation of the Mountain-Plains Education & Economic Development Program, Inc.

ERIC Educational Resources Information Center

Bale, Richard L.; Sprague, C. Fremont

The Mountain-Plains Education & Economic Development Program, which exemplifies the comprehensive, residential family-centered approach to serving the economically disadvantaged, was compared to four similar programs in the United States: Arizona Job Colleges (AJC) in Arizona; Madera Employment Training Center (METC) in California; Manpower,…

Summer High School Apprenticeship Research Program (SHARP) of the National Aeronautics and Space Administration

NASA Technical Reports Server (NTRS)

1984-01-01

A total of 125 talented high school students had the opportunity to gain first hand experience about science and engineering careers by working directly with a NASA scientist or engineer during the summer. This marked the fifth year of operation for NASA's Summer High School Apprenticehsip Research Program (SHARP). Ferguson Bryan served as the SHARP contractor and worked closely with NASA staff at Headquarters and the eight participating sites to plan, implement, and evaluate the Program. The main objectives were to strengthen SHARP and expand the number of students in the Program. These eight sites participated in the Program: Ames Research Center North, Ames' Dryden Flight Research Facility, Goddard Space Flight Center, Goddard's Wallops Flight Facility, Kennedy Space Center, Langley Research Center, Lewis Research Center, and Marshall Space Flight Center.

76 FR 12717 - Disability and Rehabilitation Research Projects and Centers Program; Field Initiated (FI...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... DEPARTMENT OF EDUCATION Disability and Rehabilitation Research Projects and Centers Program; Field...; National Institute on Disability and Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Field Initiated (FI) Projects AGENCY: Office of Special Education...

76 FR 37191 - Notice of Competition for University Transportation Centers (UTC) Program Grants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... Competition for University Transportation Centers (UTC) Program Grants AGENCY: Research and Innovative... conduct a competition for University Transportation Centers (UTC) Program grants for the purpose of... of demonstrated ability, research, technology and education resources, leadership, multi-modal...

Multi-site randomized controlled trial of a child-centered physical activity program, a parent-centered dietary-modification program, or both in overweight children: the HIKCUPS study.

PubMed

Okely, Anthony D; Collins, Clare E; Morgan, Philip J; Jones, Rachel A; Warren, Janet M; Cliff, Dylan P; Burrows, Tracy L; Colyvas, Kim; Steele, Julie R; Baur, Louise A

2010-09-01

To evaluate whether a child-centered physical activity program, combined with a parent-centered dietary program, was more efficacious than each treatment alone, in preventing unhealthy weight-gain in overweight children. An assessor-blinded randomized controlled trial involving 165 overweight/obese 5.5- to 9.9- year-old children. Participants were randomly assigned to 1 of 3 interventions: a parent-centered dietary program (Diet); a child-centered physical activity program (Activity); or a combination of both (Diet+Activity). All groups received 10 weekly face-to-face sessions followed by 3 monthly relapse-prevention phone calls. Analysis was by intention-to-treat. The primary outcome was change in body mass index z-score at 6 and 12 months (n=114 and 106, respectively). Body mass index z-scores were reduced at 12-months in all groups, with the Diet (mean [95% confidence interval]) (-0.39 [-0.51 to 0.27]) and Diet + Activity (-0.32, [-0.36, -0.23]) groups showing a greater reduction than the Activity group (-0.17 [-0.28, -0.06]) (P=.02). Changes in other outcomes (waist circumference and metabolic profile) were not statistically significant among groups. Relative body weight decreased at 6 months and was sustained at 12 months through treatment with a child-centered physical activity program, a parent-centered dietary program, or both. The greatest effect was achieved when a parent-centered dietary component was included. Copyright (c) 2010 Mosby, Inc. All rights reserved.

VUV testing of science cameras at MSFC: QE measurement of the CLASP flight cameras

NASA Astrophysics Data System (ADS)

Champey, P.; Kobayashi, K.; Winebarger, A.; Cirtain, J.; Hyde, D.; Robertson, B.; Beabout, B.; Beabout, D.; Stewart, M.

2015-08-01

The NASA Marshall Space Flight Center (MSFC) has developed a science camera suitable for sub-orbital missions for observations in the UV, EUV and soft X-ray. Six cameras were built and tested for the Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP), a joint MSFC, National Astronomical Observatory of Japan (NAOJ), Instituto de Astrofisica de Canarias (IAC) and Institut D'Astrophysique Spatiale (IAS) sounding rocket mission. The CLASP camera design includes a frame-transfer e2v CCD57-10 512 × 512 detector, dual channel analog readout and an internally mounted cold block. At the flight CCD temperature of -20C, the CLASP cameras exceeded the low-noise performance requirements (<= 25 e- read noise and <= 10 e- /sec/pixel dark current), in addition to maintaining a stable gain of ≍ 2.0 e-/DN. The e2v CCD57-10 detectors were coated with Lumogen-E to improve quantum efficiency (QE) at the Lyman- wavelength. A vacuum ultra-violet (VUV) monochromator and a NIST calibrated photodiode were employed to measure the QE of each camera. Three flight cameras and one engineering camera were tested in a high-vacuum chamber, which was configured to operate several tests intended to verify the QE, gain, read noise and dark current of the CCD. We present and discuss the QE measurements performed on the CLASP cameras. We also discuss the high-vacuum system outfitted for testing of UV, EUV and X-ray science cameras at MSFC.

Special section containing papers presented at the 13th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (Beijing, China, 17-20 September 2013) Special section containing papers presented at the 13th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (Beijing, China, 17-20 September 2013)

NASA Astrophysics Data System (ADS)

Lin, Z.

2014-10-01

In magnetic fusion plasmas, a significant fraction of the kinetic pressure is contributed by superthermal charged particles produced by auxiliary heating (fast ions and electrons) and fusion reactions (a-particles). Since these energetic particles are often far away from thermal equilibrium due to their non-Maxwellian distribution and steep pressure gradients, the free energy can excite electromagnetic instabilities to intensity levels well above the thermal fluctuations. The resultant electromagnetic turbulence could induce large transport of energetic particles, which could reduce heating efficiency, degrade overall plasma confinement, and damage fusion devices. Therefore, understanding and predicting energetic particle confinement properties are critical to the success of burning plasma experiments such as ITER since the ignition relies on plasma self-heating by a-particles. To promote international exchanges and collaborations on energetic particle physics, the biannual conference series under the auspices of the International Atomic Energy Agency (IAEA) were help in Kyiv (1989), Aspenas (1991), Trieste (1993), Princeton (1995), JET/Abingdon (1997), Naka (1999), Gothenburg (2001), San Diego (2003), Takayama (2005), Kloster Seeon (2007), Kyiv (2009), and Austin (2011). The papers in this special section were presented at the most recent meeting, the 13th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems, which was hosted by the Fusion Simulation Center, Peking University, Beijing, China (17-20 September 2013). The program of the meeting consisted of 71 presentations, including 13 invited talks, 26 oral contributed talks, 30 posters, and 2 summary talks, which were selected by the International Advisory Committee (IAC). The IAC members include H. Berk, L.G. Eriksson, A. Fasoli, W. Heidbrink, Ya. Kolesnichenko, Ph. Lauber, Z. Lin, R. Nazikian, S. Pinches, S. Sharapov, K. Shinohara, K. Toi, G. Vlad, and X.T. Ding. The conference program, abstracts of all papers, and slides of oral presentations are available at the conference website:www.phy.pku.edu.cn/fsc/w18419.jsp As a measure of the breadth in current research activities, a wide range of topics in energetic particle physics were covered in the meeting program, including dynamics of various Alfvén eigenmodes and energetic particle modes, energetic particle transport, energetic particle effects on magnetohydrodynamic (MHD) modes, runaway electrons, and diagnostics of energetic particles and neutrons. Energetic particle experiments were reported on tokamaks, stellarators, spherical tori, reversed field pinches, and linear devices. Most of the papers have direct comparisons between experimental data and simulation results, a very healthy trend in the research of energetic particle physics. As an indication for the depth in current research activities and possible future directions in energetic particle physics, some exciting progress reported at the meeting is highlighted here. The 3D fields of resonant magnetic perturbations (RMP) for controlling edge localized modes (ELM) are found to drive significant ripple loss of fast ions in DIII-D and ASDEX-U experiments. Similar loss is predicted for ITER RMP fields in the vacuum approximation. Fortunately, plasma response to RMP fields is found by the simulation to reduce the loss of fast ions and α-particles to a benign level. These results call for more accurate measurements and more reliable modeling of the plasma response to RMP fields in existing tokamak experiments and in future ITER experiments. Interesting progress on energetic particle transport by Alfvén eigenmodes was made in reduced 1D models based on the critical gradients model, in which energetic particle pressure gradients are relaxed to the local threshold of Alfvén eigenmode stability. Some experimental support for the critical gradient model was reported in DIII-D off-axis neutral beam injection (NBI) experiments, in which the fast-ion density relaxes to similar profiles for all injection angles. Further verification and validation of these reduced models by existing tokamak experiments and nonlinear simulations are needed. Impressive progress in first-principles simulations of Alfvén eigenmodes and energetic particle transport was prominently featured at the meeting. Rigorous verification and validation have been successfully carried out for global gyrokinetic simulations of Alfvén eigenmodes with kinetic effects of thermal plasmas and non-perturbative contributions by energetic particles. The gyrokinetic turbulence simulation provides an indispensable new capability for studying the nonlinear physics of energetic particles and Alfvén eigenmodes by incorporating important physics of radial variations and toroidal mode coupling. For example, gyrokinetic simulations have found nonlinear oscillations of Alfvén eigenmode amplitude and frequency consistent with experimental observations. With better understanding of linear and nonlinear properties of Alfvén eigenmodes, a fruitful future direction is the self-consistent simulation of energetic particle transport, which requires long time simulations of nonlinear interactions between multiple Alfvén eigenmodes. A significant step in this direction has been taken by MHD-gyrokinetic hybrid simulations, which have demonstrated that fast ion profile is flattened by enhanced transport due to resonance overlaps in multiple interacting Alfvén eigenmodes with realistic amplitudes. A very interesting physics here is that the re-distribution of the energetic particle profile by an initially dominant Alfvén eigenmode leads to the excitation of other Alfvén eigenmodes. The broaden phase space volume for the extraction of free energy can then drive large fluctuation amplitudes and enhanced energetic particle transport. Some experimental evidences of such indirect interaction of multiple modes through energetic particles were observed in JT-60U and ASDEX-U experiments. Thirteen papers presented at the meeting were reviewed to the usual high standard of Nuclear Fusion and published in this special section. On behalf of the IAC, I would like to thank all participants for their contributions to this conference and to thank Nuclear Fusion for publishing this special section. The next meeting of this series will be organized by Simon Pinches and will be held at the IAEA headquarters in Vienna, in the fall of 2015.

American Overseas Research Centers Program

ERIC Educational Resources Information Center

Office of Postsecondary Education, US Department of Education, 2012

2012-01-01

The American Overseas Research Centers Program provides grants to overseas research centers that are consortia of U.S. institutions of higher education to enable the centers to promote postgraduate research, exchanges, and area studies. Eligible applicants are those consortia of U.S. institutions of higher education centers that: (1) Receive more…

76 FR 4451 - Privacy Act of 1974; Report of Modified or Altered System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

..., Atlanta Human Resources Center (AHRC), Centers for Disease Control and Prevention (CDC), Department of... maintained by the Atlanta Human Resources Center (AHRC), Scientific Resources Program, Material, Data and...) Centers for Disease Control and Prevention (CDC) Atlanta Human Resources Center (AHRC) Fellowship Program...

Honoring 15 Years of the 21st Century Community Learning Centers Program: A Polity-Centered Analysis

ERIC Educational Resources Information Center

Phillips, Sarah Fierberg

2010-01-01

Emphasizing the intersection of policy and politics, this paper uses Theda Skocpol's polity-centered approach (1992) to analyze two key moments in the history of the 21st Century Community Learning Centers (CCLC) program: (1) 1998, when the program's budget grew from $40 million to $200 million; and (2) 2003, when President Bush attempted to cut…

Outreach programs in physics at Hampton University

NASA Astrophysics Data System (ADS)

Pittman, Carlane J.; Temple, Doyle A.

1996-07-01

The Department of Physics at Hampton University generates over 4.5 M dollars of external research funding annually and operates three research centers, the Nuclear High Energy Physics Research Center, the Research Center for Optical Physics, and the Center for Fusion Training and Research. An integral component of these centers is an active outreach and recruitment program led by the Associate Director for Outreach. This program includes summer internships and research mentorships, both at Hampton University and at national laboratories such as CEBAF and NASA Langley. Faculty presentations ar local area elementary schools, middle schools and high schools are also under the auspices of this program.

20 CFR 638.502 - Job Corps basic education program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... as a second language (ESL) programs for selected center operators (regional offices shall arrange for the assignment of selected applicants needing ESL programs to the centers where such programs are...

7 CFR 4284.1003 - Program administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Agriculture Innovation Demonstration Centers § 4284.1003 Program administration. The Agriculture Innovation Demonstration Center program is...

7 CFR 4284.1003 - Program administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Agriculture Innovation Demonstration Centers § 4284.1003 Program administration. The Agriculture Innovation Demonstration Center program is...

7 CFR 4284.1003 - Program administration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Agriculture Innovation Demonstration Centers § 4284.1003 Program administration. The Agriculture Innovation Demonstration Center program is...

7 CFR 4284.1003 - Program administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Agriculture Innovation Demonstration Centers § 4284.1003 Program administration. The Agriculture Innovation Demonstration Center program is...

7 CFR 4284.1003 - Program administration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Agriculture Innovation Demonstration Centers § 4284.1003 Program administration. The Agriculture Innovation Demonstration Center program is...

EDITORIAL: Special issue containing papers presented at the 11th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems Special issue containing papers presented at the 11th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems

NASA Astrophysics Data System (ADS)

Kolesnichenko, Ya.

2010-08-01

The history of fusion research resembles the way in which one builds skyscrapers: laying the first foundation stone, one thinks about the top of the skyscraper. At the early stages of fusion, when it became clear that the thermonuclear reactor would operate with DT plasma confined by the magnetic field, the study of the `top item'—the physics of 3.5 MeV alpha particles produced by the DT fusion reaction—was initiated. The first publications on this topic appeared as long ago as the 1960s. At that time, because the physics of alpha particles was far from the experimental demand, investigations were carried out by small groups of theoreticians who hoped to discover important and interesting phenomena in this new research area. Soon after the beginning of the work, theoreticians discovered that alpha particles could excite various instabilities in fusion plasmas. In particular, at the end of the 1960s an Alfvén instability driven by alpha particles was predicted. Later it turned out that a variety of Alfvén instabilities with very different features does exist. Instabilities with perturbations of the Alfvénic type play an important role in current experiments; it is likely that they will affect plasma performance in ITER and future reactors. The first experimental manifestation of instabilities excited by superthermal particles in fusion devices was observed in the PDX tokamak in 1983. In this device a large-scale instability—the so called `fishbone instability'—associated with ions produced by the neutral beam injection resulted in a loss of a large fraction of the injected energy. Since then, the study of energetic-ion-driven instabilities and the effects produced by energetic ions in fusion plasmas has attracted the growing attention of both experimentalists and theorists. Recognizing the importance of this topic, the first conference on fusion alpha particles was held in 1989 in Kyiv under the auspices of the IAEA. The meeting in Kyiv and several subsequent meetings (Aspenäs (1991), Trieste (1993), Princeton (1995), and JET/Abingdon (1997)) were entitled `Alpha Particles in Fusion Research'. During the JET/Abingdon meeting in 1997 it was decided to extend the topic by including other suprathermal particles, in particular accelerated electrons, and rename the meetings accordingly. The subsequent meetings with the current name `Energetic Particles in Magnetic Confinement Systems' were held in Naka (1999), Gothenburg (2001), San Diego (2003), Takayama (2005) and Kloster Seeon (2007). The most recent meeting in this series was held in Kyiv, Ukraine, in September 2009. This was an anniversary meeting, 20 years after the first meeting. Like the first meeting, it was hosted by the Institute for Nuclear Research, National Academy of Sciences of Ukraine. It was attended by about 80 researchers from 18 countries, ITER, and EC. The program of the meeting consisted of 78 presentations, including 12 invited talks, 16 oral contributed talks, and 50 posters, which were selected by the International Advisory Committee (IAC). The IAC consisted of 11 people representing EC (L.-G. Eriksson), Germany (S. Günter), Italy (F. Zonca), Japan (K. Shinohara and K. Toi), Switzerland (A. Fasoli), UK (S. Sharapov), Ukraine (Ya. Kolesnichenko—IAC Chair), USA (H. Berk, W. Heidbrink, and R. Nazikian). The meeting program covered a wide range of physics issues concerning energetic ions in toroidal fusion facilities—tokamaks, stellarators, and spherical tori. Many new interesting and practically important results of both experimental and theoretical studies were reported. The research presented covered topics such as instabilities driven by energetic ions, transport of energetic ions caused by plasma microturbulence and destabilized eigenmodes, non-linear phenomena induced by the instabilities, classical transport processes, effects of runaway electrons, diagnostics of energetic ions and plasmas, and aspects of ITER physics. In addition to these topics, which were also covered at previous conferences in this series and have become conventional, experimental and theoretical results on the influence of energetic ions on bulk plasma transport properties were also reported. Some materials from the meeting are available on the web page http://www.kinr.kiev.ua/TCM/index.html. 24 of the works presented at the meeting are published in this special issue. These works were reviewed to the usual high standard of Nuclear Fusion. The guest editor of this special issue is grateful to the publishers for their cooperation.

Kennedy Space Center Director Update

NASA Image and Video Library

2014-03-06

CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. An attendee talks with Trent Smith, program manager, and Tammy Belk, a program specialist, at the ISS Ground Processing and Research Office display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper

Developing Healthy Adolescents--A Progressive Health Care Partnership Program.

ERIC Educational Resources Information Center

Griesemer, Bernard A.; Hough, David L.

1993-01-01

A 1991 partnership coupling Southwest Missouri State University with Saint John's Regional Health Center spawned the Midwest Sports Medicine Center, originally designed to treat orthopedic injuries. Soon the center developed major educational initiatives, including SportsPACE, a program integrating health care programs into the secondary core…

Resident Program Guide: Hillside Outdoor Education Center.

ERIC Educational Resources Information Center

Sommer, Bonnie

Founded in 1972 as part of the private, non-profit Edwin Gould Outdoor Education Centers, the Hillside Outdoor Education Center offers services to various educational groups by providing residential experiences for students and faculty, day-visit programs, school-site outdoor education programs, teacher workshops, college courses in outdoor…

76 FR 15964 - Funding Priorities: Disability and Rehabilitation Research Projects and Centers Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... past five years, the DBTACs have published numerous journal articles, held a series of research... and Rehabilitation Research Projects and Centers Program AGENCY: Office of Special Education and... Disability and Rehabilitation Research Projects and Centers Program administered by the National Institute on...

NASA LANGLEY RESEARCH CENTER AND THE TIDEWATER INTERAGENCY POLLUTION PREVENTION PROGRAM

EPA Science Inventory

National Aeronautics and Space Administration (NASA)'s Langley Research Center (LaRC) is an 807-acre research center devoted to aeronautics and space research. aRC has initiated a broad-based pollution prevention program guided by a Pollution Prevention Program Plan and implement...

Lincoln County Primary Care Center Is a Model for Good Health.

ERIC Educational Resources Information Center

Casto, James E.

1992-01-01

Describes a rural West Virginia health-care center as a successful model program for integration between the clinic and community. Describes center facilities, funding sources, community cooperation, and cooperative residency program with regional medical school. Discusses implications for other medical-education programs. Describes differences…

Contact Us | Center for Cancer Research

Cancer.gov

Program Contact Program Manager Anuradha Budhu, Ph.D. Program Manager, NCI CCR Liver Cancer Program Senior Associate Scientist, Liver Carcinogenesis Section Laboratory of Human Carcinogenesis NCI Center for Cancer Research Tel: 240-760-6837

Patient goal setting as a method for program improvement/development in partial hospitalization programs.

PubMed

Gates, A

1991-12-01

Data were collected from a study of 49 patients in 1990 and 106 patients in 1991 admitted into Country View Treatment Center and Green Country Counseling Center. Country View is a 30-bed chemical dependency residential center operating under St. John Medical Center in Tulsa, Oklahoma. Green Country is an evening partial hospital chemical dependency program operating under St. John Medical Center in Tulsa, Oklahoma, The tools used in this study were the Country View Patient Self-Reporting Questionnaire, the global Rating Scale, and the Model of Recovering Alcoholics Behavior Stages and Goal Setting (Wing, 1990). These assessments were specifically designed to measure the patient's perceptions of goal setting and the patient's perspective on treatment outcome. The study outcome resulted in program improvement (Green Country evening partial hospital program) and the development of the Country View Substance Abuse Intermediate Link (SAIL) Program (day partial hospital).

From the Field: Carbofuran detected on weathered raptor carcass feet

USGS Publications Warehouse

Vyas, N.B.; Spann, J.W.; Hulse, C.S.; Bauer, W.; Olson, S.

2005-01-01

The cause of death for raptors poisoned at illegal carbofuran-Iaced predator baits is often not confirmed because the carcass matrices that are conventionally analyzed are not available due to decomposition and scavenging. However, many such carcasses retain intact feet that may have come into contact with carbofuran. Eastern screech owls (Otus asio) were exposed to carbofuran via simulated predator baits. Detection of carbofuran from owl feet weathered for 28 days demonstrated the temporal reliability of using feet during a forensic investigation. Raptor carcasses previously not submitted for residue analysis because of a lack of the conventional matrices may now be salvaged for their feet.

Detection of endogenous boldenone in the entire male horses.

PubMed

Ho, Emmie N M; Yiu, Kenneth C H; Tang, Francis P W; Dehennin, Louis; Plou, Philippe; Bonnaire, Yves; Wan, Terence S M

2004-09-05

Boldenone (1,2-dehydrotestosterone) is a common veterinary anabolic agent. Its structure is very similar to testosterone. Testosterone is endogenous in the horse, whereas there has been no report concerning the detection of endogenous boldenone. This paper reports the direct observation of sulphate conjugate of boldenone in equine urine from entires. The detection procedures involved solid-phase extraction, immunoaffinity column (IAC) purification, and then LC-MS-MS analysis on a Q-ToF instrument. The identification of boldenone sulphate has provided direct evidence for the endogenous nature of boldenone in entire male horses. Quantification data for the normal level of boldenone in Hong Kong racehorses will also be discussed.

Virgin's Knight tackles climate change

NASA Astrophysics Data System (ADS)

Banks, Michael

2008-11-01

"There is no greater or more immediate challenge than that posed by climate change," said Sir Richard Branson, chairman of the Virgin group, via video-link at the 59th International Astronautical Congress (IAC) held in Glasgow in the UK at the end of September. That grand statement may seem like a lot of hot air for the entrepreneur best known for his attempt to circumnavigate the globe by balloon. But Branson went on to reveal that Virgin Galactic, which aims to fly passengers 100 km into space for 200 000 per trip, will also provide room on its craft for a series of scientific experiments to study the Earth's atmosphere.

EDITSPEC: Basic Procedures Manual,

DTIC Science & Technology

1981-11-15

0 ag 0 6 s a ~ m.0~~ 0. uj u2 cc 200 , 50 M. - 3- *-a 0. a "a . OC 0aU b-, 00 6. c v a am u ascU Amu soa- o o ’. ~ *ac ~ ~ . i.ac 6*~~~ ~ .0 A0s c...8217 ’,z +a’ . -ll v .0 •%d* go J e mJ.,.bfJ .. 6. . . O ~ ~ ~ 6 A ,, 0i uu2 jA b. OZa U q r. -a 3 U Ua 2 1 a e g g g U ~ u ~ .1H .- a.i h Ag ;I I W

U. S. Naval Forces, Vietnam Monthly Historical Summary for November 1969

DTIC Science & Technology

1970-01-01

D & E) LIST V (A) LIST VI (A 2&2, DI, E & H14) I .-’-.5 S2.2 ŕ 7 - UNCLASSWIFIE•.-. .. •. ’• -o- --. * --" U.~~~~ S . NAALFOCE Vi~ri...Vi V ’ ’-* 0S a,- 0 - 00 - _ d 0 00El IAC~ CV V V . ~ El ( V ( V ~i 500 GO en I A- s ’ ~ S ~-. otoU - 1 (12 a (Vs Eli a ( V -mc PE 0 - *~~i ss .8 E8.Ela 0...Nov. 7. S E S - -3 No v . 4 D . SEA FLOAT - l14 Nov. :E. SEA

76 FR 35474 - UAW-Chrysler Technical Training Center, Technology Training Joint Programs Staff, Including On...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

...-Chrysler Technical Training Center, Technology Training Joint Programs Staff, Including On-Site Leased Workers From Cranks, O/E Learning, DBSI, IDEA, and Tonic/MVP, Detroit, MI; UAW-Chrysler Technical Training... workers and former workers of UAW-Chrysler Technical Training Center, Technology Training Joint Programs...

A Program of Research and Education in Astronautics at the NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Tolson, Robert H.

2000-01-01

The objectives of the Program were to conduct research at the NASA Langley Research Center in the area of astronautics and to provide a comprehensive education program at the Center leading to advanced degrees in Astronautics. We believe that the program has successfully met the objectives and has been of significant benefit to NASA LaRC, the GWU and the nation.

A qualitative evaluation of the 2005-2011 National Academic Centers of Excellence in Youth Violence Prevention Program.

PubMed

Holland, Kristin M; Vivolo-Kantor, Alana M; Dela Cruz, Jason; Massetti, Greta M; Mahendra, Reshma

2015-12-01

The Centers for Disease Control and Prevention's Division of Violence Prevention (DVP) funded eight National Academic Centers of Excellence (ACEs) in Youth Violence Prevention from 2005 to 2010 and two Urban Partnership Academic Centers of Excellence (UPACEs) in Youth Violence Prevention from 2006 to 2011. The ACEs and UPACEs constitute DVP's 2005-2011 ACE Program. ACE Program goals include partnering with communities to promote youth violence (YV) prevention and fostering connections between research and community practice. This article describes a qualitative evaluation of the 2005-2011 ACE Program using an innovative approach for collecting and analyzing data from multiple large research centers via a web-based Information System (ACE-IS). The ACE-IS was established as an efficient mechanism to collect and document ACE research and programmatic activities. Performance indicators for the ACE Program were established in an ACE Program logic model. Data on performance indicators were collected through the ACE-IS biannually. Data assessed Centers' ability to develop, implement, and evaluate YV prevention activities. Performance indicator data demonstrate substantial progress on Centers' research in YV risk and protective factors, community partnerships, and other accomplishments. Findings provide important lessons learned, illustrate progress made by the Centers, and point to new directions for YV prevention research and programmatic efforts. Published by Elsevier Ltd.

NASA HUNCH Hardware

NASA Technical Reports Server (NTRS)

Hall, Nancy R.; Wagner, James; Phelps, Amanda

2014-01-01

What is NASA HUNCH? High School Students United with NASA to Create Hardware-HUNCH is an instructional partnership between NASA and educational institutions. This partnership benefits both NASA and students. NASA receives cost-effective hardware and soft goods, while students receive real-world hands-on experiences. The 2014-2015 was the 12th year of the HUNCH Program. NASA Glenn Research Center joined the program that already included the NASA Johnson Space Flight Center, Marshall Space Flight Center, Langley Research Center and Goddard Space Flight Center. The program included 76 schools in 24 states and NASA Glenn worked with the following five schools in the HUNCH Build to Print Hardware Program: Medina Career Center, Medina, OH; Cattaraugus Allegheny-BOCES, Olean, NY; Orleans Niagara-BOCES, Medina, NY; Apollo Career Center, Lima, OH; Romeo Engineering and Tech Center, Washington, MI. The schools built various parts of an International Space Station (ISS) middeck stowage locker and learned about manufacturing process and how best to build these components to NASA specifications. For the 2015-2016 school year the schools will be part of a larger group of schools building flight hardware consisting of 20 ISS middeck stowage lockers for the ISS Program. The HUNCH Program consists of: Build to Print Hardware; Build to Print Soft Goods; Design and Prototyping; Culinary Challenge; Implementation: Web Page and Video Production.

77 FR 34359 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Projects and Centers Program; Traumatic Brain Injury Model Systems Centers AGENCY: Office of Special... Brain Injury Model Systems Centers (TBIMS). Notice inviting applications for new awards for fiscal year... 28, 2006 (71 FR 25472). The Traumatic Brain Injury Model Systems Centers priority is from the notice...

Training and technical assistance to enhance capacity building between prevention research centers and their partners.

PubMed

Spadaro, Antonia J; Grunbaum, Jo Anne; Dawkins, Nicola U; Wright, Demia S; Rubel, Stephanie K; Green, Diane C; Simoes, Eduardo J

2011-05-01

The Centers for Disease Control and Prevention has administered the Prevention Research Centers Program since 1986. We quantified the number and reach of training programs across all centers, determined whether the centers' outcomes varied by characteristics of the academic institution, and explored potential benefits of training and technical assistance for academic researchers and community partners. We characterized how these activities enhanced capacity building within Prevention Research Centers and the community. The program office collected quantitative information on training across all 33 centers via its Internet-based system from April through December 2007. Qualitative data were collected from April through May 2007. We selected 9 centers each for 2 separate, semistructured, telephone interviews, 1 on training and 1 on technical assistance. Across 24 centers, 4,777 people were trained in 99 training programs in fiscal year 2007 (October 1, 2006-September 30, 2007). Nearly 30% of people trained were community members or agency representatives. Training and technical assistance activities provided opportunities to enhance community partners' capacity in areas such as conducting needs assessments and writing grants and to improve the centers' capacity for cultural competency. Both qualitative and quantitative data demonstrated that training and technical assistance activities can foster capacity building and provide a reciprocal venue to support researchers' and the community's research interests. Future evaluation could assess community and public health partners' perception of centers' training programs and technical assistance.

KSC-2009-5248

NASA Image and Video Library

2009-09-25

CAPE CANAVERAL, Fla. – This ribbon cutting officially turns over NASA Kennedy Space Center's Launch Control Center Firing Room 1 from the Space Shuttle Program to the Constellation Program. Participating are (from left) Pepper Phillips, director of the Constellation Project Office at Kennedy; Bob Cabana, Kennedy's director; Robert Crippen, former astronaut; Jeff Hanley, manager of the Constellation Program at NASA's Johnson Space Center; and Nancy Bray, deputy director of Center Operations at Kennedy. The room has undergone demolition and construction and been outfitted with consoles for the upcoming Ares I-X rocket flight test targeted for launch on Oct. 27. As the center of launch operations at Kennedy since the Apollo Program, the Launch Control Center, or LCC, has played a central role in NASA's human spaceflight programs. Firing Room 1 was the first operational firing room constructed. From this room, controllers launched the first Saturn V, the first crewed flight of Saturn V, the first crewed mission to the moon and the first space shuttle. Firing Room 1 will continue this tradition of firsts when controllers launch the Constellation Program's first flight test. Also, this firing room will be the center of operations for the upcoming Ares I and Orion operations. Photo credit: NASA/Kim Shiflett

The 1985 National Aeronautics and Space Administration's Summer High School Apprenticeship Research Program (SHARP)

NASA Technical Reports Server (NTRS)

1985-01-01

In 1985, a total of 126 talented high school students gained first hand knowledge about science and engineering careers by working directly with a NASA scientist or engineer during the summer. This marked the sixth year of operation for NASA's Summer High School Apprenticeship Research Program (SHARP). The major priority of maintaining the high standards and success of prior years was satisfied. The following eight sites participated in the Program: Ames Research Center, Ames' Dryden Flight Research Facility, Goddard Space Flight Center, Goddard's Wallop Flight Facility, Kennedy Space Center, Langley Research Center, Lewis Research Center, and Marshall Space Flight Center. Tresp Associates served as the SHARP contractor and worked closely with NASA staff at headquarters and the sites just mentioned to plan, implement, and evaluate the program.

[Primary care centers and breast-feeding].

PubMed

Nacher Fernández, A; Sanantonio Valdearcos, F; Barreda Simó, I; Palau Fuster, G; Palomares Gimeno, M J; Agramunt Soler, G; Fabregat Julve, I; Labordena Barceló, C

2001-09-01

To study activities that promote, maintain and support breast feeding in primary care centers in our health district and to evaluate the commitment of health center directors' to breast feeding, their knowledge of the subject, and programs involved in the promotion of natural breast-feeding. A cross-sectional study was carried out through surveys to those in charge of health centers, nursing, pediatric programs and pregnancy programs. Eighty surveys were sent to center and program directors. Answers were obtained from 66.2 %. A total of 6.9 % of the centers had no program or protocol for the promotion and maintenance of breast-feeding, nor did they seek the collaboration of support groups. Only 28.8 % of the centers surveyed carried out activities that provided special support to mothers with difficulties in breast-feeding. In contrast, 80.4 % possessed an adequate register on the incidence of breast-feeding. In 74.5 % of the centers, health professionals were given no specific training on the subject. Only 14.9 % of the centers had rules prohibiting visible leaflets, posters or samples of formula milk. In 84.6 % of the centers, no place was provided where breast-feeding could be carried out, observed, and possible problems corrected. Most of the primary care centers surveyed do not promote programmed activities favoring the promotion and maintenance of breast-feeding. Nevertheless, many centers provide advice on breast-feeding. Collaboration with support groups or other resources that might exist in the community is not generally sought. Specific training in breast-feeding is not given to the centers' health professionals. Only a minority of the centers possesses an appropriate place where mothers can breast-feed if they wish and where the process of breast-feeding can be observed and modified. The results suggest that primary care centers do not provide the necessary support to ensure successful breast-feeding and that they lack the resources necessary to achieve this aim.

Maximizing the value of a breast center.

PubMed

Goldman, Mickey; Chang, Dan

2010-08-01

This article focuses on the value and benefit of a Breast Center to an organization by identifying the best ways to maximize their contribution in order to create and sustain a financially viable, clinically respected and community-oriented Breast Center. The goal of the Breast Center is to ultimately benefit the community and the hospital's Comprehensive Cancer Program as a whole. The value propositions are divided into three areas that have positive impacts to the program and hospital, collectively. These value propositions are: 1. Financial Value e identified values of the Breast Center that contribute to the bottom line - or Return on Investment (ROI) - of the Cancer Program. 2. Clinical Quality Values - identified values of the Breast Center that improve the quality of care and outcomes of the patients. 3. Intangibles Values - identified values of the Breast Center that connect to the community and women that is invaluable to the Cancer Program. 2010 Elsevier Ltd. All rights reserved.

Evaluation of a federally funded workforce development program: The Centers for Public Health Preparedness☆

PubMed Central

Sobelson, Robyn K.; Young, Andrea C.

2017-01-01

The Centers for Public Health Preparedness (CPHP) program was a five-year cooperative agreement funded by the Centers for Disease Control and Prevention (CDC). The program was initiated in 2004 to strengthen terrorism and emergency preparedness by linking academic expertise to state and local health agency needs. The purposes of the evaluation study were to identify the results achieved by the Centers and inform program planning for future programs. The evaluation was summative and retrospective in its design and focused on the aggregate outcomes of the CPHP program. The evaluation results indicated progress was achieved on program goals related to development of new training products, training members of the public health workforce, and expansion of partnerships between accredited schools of public health and state and local public health departments. Evaluation results, as well as methodological insights gleaned during the planning and conduct of the CPHP evaluation, were used to inform the design of the next iteration of the CPHP Program, the Preparedness and Emergency Response Learning Centers (PERLC). PMID:23380597

Research and technology at Kennedy Space Center

NASA Technical Reports Server (NTRS)

1989-01-01

As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing increasing emphasis on the Center's research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of current mission, the technical tools are developed needed to execute Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation and is responsible for implementation of the majority of the projects in this Kennedy Space Center 1989 Annual Report.

75 FR 13521 - Centers for Independent Living Program-Training and Technical Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... DEPARTMENT OF EDUCATION Centers for Independent Living Program--Training and Technical Assistance... for Independent Living Program--Training and Technical Assistance (CIL-TA program). The Assistant... appropriated for the CIL program to provide training and technical assistance to CILs, agencies eligible to...

NASA Langley Research Center outreach in astronautical education

NASA Technical Reports Server (NTRS)

Duberg, J. E.

1976-01-01

The Langley Research Center has traditionally maintained an active relationship with the academic community, especially at the graduate level, to promote the Center's research program and to make graduate education available to its staff. Two new institutes at the Center - the Joint Institute for Acoustics and Flight Sciences, and the Institute for Computer Applications - are discussed. Both provide for research activity at the Center by university faculties. The American Society of Engineering Education Summer Faculty Fellowship Program and the NASA-NRC Postdoctoral Resident Research Associateship Program are also discussed.

Language Resource Centers Program

ERIC Educational Resources Information Center

Office of Postsecondary Education, US Department of Education, 2012

2012-01-01

The Language Resource Centers (LRC) program provides grants to institutions of higher education to establish, strengthen, and operate resource centers that serve to improve the nation's capacity to teach and learn foreign languages. Eligible applicants are institutions of higher education. Duration of the grant is four years. Center activities…

Joint Space Operations Center (JSpOC) Mission System Increment 3 (JMS Inc 3)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Joint Space Operations Center (JSpOC) Mission System Increment 3 (JMS Inc 3) Defense...1725 DSN Phone: DSN Fax: Date Assigned: May 16, 2014 Program Information Program Name Joint Space Operations Center (JSpOC) Mission System...approved program baseline; therefore, no Original Estimate has been established. JMS Inc 3 2016 MAR UNCLASSIFIED 4 Program Description The Joint Space

34 CFR 464.1 - What is the State Literacy Resource Centers Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... purpose of sharing information, data, research, and expertise and literacy resources. (Authority: 20 U.S.C... 34 Education 3 2010-07-01 2010-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM...

Success in Early Intervention: The Chicago Child-Parent Centers.

ERIC Educational Resources Information Center

Reynolds, Arthur J.

Although early intervention programs have enjoyed popular and legislative support, little hard data exist on the long-term consequences of these efforts. This study examined the long-term effects of the Child-Parent Center (CPC) program in Chicago. Begun in 1967, the program operates out of 24 centers, located in proximity to the elementary…

77 FR 34941 - Privacy Act of 1974; Notice of a Computer Matching Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

...; Notice of a Computer Matching Program AGENCY: Defense Manpower Data Center, DoD. ACTION: Notice of a... computer matching program are the Department of Veterans Affairs (VA) and the Defense Manpower Data Center... identified as DMDC 01, entitled ``Defense Manpower Data Center Data Base,'' last published in the Federal...

77 FR 35432 - Privacy Act of 1974, Computer Matching Program: United States Postal Service and the Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... the Defense Manpower Data Center, Department of Defense AGENCY: Postal Service TM . ACTION: Notice of Computer Matching Program--United States Postal Service and the Defense Manpower Data Center, Department of... as the recipient agency in a computer matching program with the Defense Manpower Data Center (DMDC...

34 CFR 464.1 - What is the State Literacy Resource Centers Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... purpose of sharing information, data, research, and expertise and literacy resources. (Authority: 20 U.S.C... 34 Education 3 2011-07-01 2011-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM...

34 CFR 464.1 - What is the State Literacy Resource Centers Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... purpose of sharing information, data, research, and expertise and literacy resources. (Authority: 20 U.S.C... 34 Education 3 2012-07-01 2012-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM...

34 CFR 464.1 - What is the State Literacy Resource Centers Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... purpose of sharing information, data, research, and expertise and literacy resources. (Authority: 20 U.S.C... 34 Education 3 2013-07-01 2013-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM...

34 CFR 464.1 - What is the State Literacy Resource Centers Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... purpose of sharing information, data, research, and expertise and literacy resources. (Authority: 20 U.S.C... 34 Education 3 2014-07-01 2014-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM...

Trends in HIV Terminology: Text Mining and Data Visualization Assessment of International AIDS Conference Abstracts Over 25 Years.

PubMed

Dancy-Scott, Nicole; Dutcher, Gale A; Keselman, Alla; Hochstein, Colette; Copty, Christina; Ben-Senia, Diane; Rajan, Sampada; Asencio, Maria Guadalupe; Choi, Jason Jongwon

2018-05-04

The language encompassing health conditions can also influence behaviors that affect health outcomes. Few published quantitative studies have been conducted that evaluate HIV-related terminology changes over time. To expand this research, this study included an analysis of a dataset of abstracts presented at the International AIDS Conference (IAC) from 1989 to 2014. These abstracts reflect the global response to HIV over 25 years. Two powerful methodologies were used to evaluate the dataset: text mining to convert the unstructured information into structured data for analysis and data visualization to represent the data visually to assess trends. The purpose of this project was to evaluate the evolving use of HIV-related language in abstracts presented at the IAC from 1989 to 2014. Over 80,000 abstracts were obtained from the International AIDS Society and imported into a Microsoft SQL Server database for data processing and text mining analyses. A text mining module within the KNIME Analytics Platform, an open source software, was then used to mine the partially processed data to create a terminology corpus of key HIV terms. Subject matter experts grouped the terms into categories. Tableau, a data visualization software, was used to visualize the frequency metrics associated with the terms as line graphs and word clouds. The visualized dashboards were reviewed to discern changes in terminology use across IAC years. The major findings identify trends in HIV-related terminology over 25 years. The term "AIDS epidemic" was dominantly used from 1989 to 1991 and then declined in use. In contrast, use of the term "HIV epidemic" increased through 2014. Beginning in the mid-1990s, the term "treatment experienced" appeared with increasing frequency in the abstracts. Use of terms identifying individuals as "carriers or victims" of HIV rarely appeared after 2008. Use of the terms "HIV positive" and "HIV infected" peaked in the early-1990s and then declined in use. The terms "men who have sex with men" and "MSM" were rarely used until 1994; subsequently, use of these terms increased through 2014. The term "sex worker" steadily increased in frequency throughout conference years, whereas the term "prostitute" decreased over time. The results of this study highlight changes in HIV terminology use over 25 years, including the addition, disappearance, and changing use of terms that reflect advances in HIV research and medical practice and destigmatization of the disease. Coupled with findings from related quantitative research, HIV-related terminology recommendations based on results of this study are included. Adoption of these recommendations will further efforts to use less stigmatizing language and facilitate effective communication between health professionals and people affected by HIV. ©Nicole Dancy-Scott, Gale A Dutcher, Alla Keselman, Colette Hochstein, Christina Copty, Diane Ben-Senia, Sampada Rajan, Maria Guadalupe Asencio, Jason Jongwon Choi. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 04.05.2018.

99mTc-labeling of Peptidomimetic Antagonist to Selectively Target αvβ3 Receptor-Positive Tumor: Comparison of PDA and EDDA as co-Ligands

PubMed Central

Shin, In Soo; Maeng, Jin Soo; Jang, Beom-Su; You, Eric; Cheng, Kenneth; Li, King C.P; Wood, Bradford; Carrasquillo, Jorge A.; Danthi, S. Narasimhan; Paik, Chang H.

2010-01-01

Objectives The aim of this research was to synthesize radiolabeled peptidomimetic integrin αvβ3 antagonist with 99mTc for rapid targeting of integrin αvβ3 receptors in tumor to produce a high tumor to background ratio. Methods The amino terminus of 4-[2-(3,4,5,6-tetra-hydropyrimidin-2-ylamino)-ethyloxy]benzoyl-2-(S)-[N-(3-amino-neopenta-1-carbamyl)]-aminoethylsulfonyl-amino-β-alanine hydrochloride (IAC) was conjugated with N-hydroxysuccinimide ester of HYNIC and labeled with 99mTc using tricine with either 1,5-pyridinedicarboxylic acid (PDA) or ethylenediamine-N,N′-diacetic acid (EDDA) as the co-ligand. The products, 99mTc EDDA2/HYNIC-IAC (P1) and 99mTc PDA (tricin)/HYNIC-IAC (P2) were subjected to in vitro serum stability, receptor-binding, biodistribution and imaging studies. Results P1 and P2 were synthesized with an overall yield of >80%. P1 was slightly more stable than P2 when incubated in serum at 37 °C for 18 hrs (84 vs 77% intact). The In vitro receptor-binding of P1 was higher than that of P2 (78.02 ± 13.48 vs 51.05 ± 14.05%) when incubated with αvβ3 at a molar excess (0.8 μM). This receptor binding was completely blocked by a molar excess of an unlabeled peptidomimetic antagonist. Their differences shown in serum stability and the receptor-binding appeared to be related to their biological behaviors in tumor uptake and retention; the 1 h tumor uptakes of P1 and P2 were 3.17±0.52 and 2.13±0.17 % ID/g, respectively. P1 was retained in the tumor longer than P2. P1 was excreted primarily through the renal system whereas P2 complex was excreted equally via both renal and hepatobiliary systems. Thus, P1 was retained in the whole-body with 27.25 ± 3.67% ID at 4 h whereas 54.04 ± 3.57% ID of P2 remained in the whole-body at 4 h. This higher whole-body retention of P2 appeared to be resulted from a higher amount of radioactivity retained in liver and intestine. These findings were supported by imaging studies showing higher tumor-to-abdominal contrast for P1 than for P2 at 3 h postinjection. Conclusions P1 showed good tumor targeting properties with a rapid tumor uptake, prolonged tumor retention and fast whole-body clearance kinetics. These findings warrant further investigation of the HYNIC method of 99mTc labeling of other peptidomimetic antagonists using EDDA as a coligand. PMID:20556233

NASA Propulsion Engineering Research Center, volume 1

NASA Technical Reports Server (NTRS)

1993-01-01

Over the past year, the Propulsion Engineering Research Center at The Pennsylvania State University continued its progress toward meeting the goals of NASA's University Space Engineering Research Centers (USERC) program. The USERC program was initiated in 1988 by the Office of Aeronautics and Space Technology to provide an invigorating force to drive technology advancements in the U.S. space industry. The Propulsion Center's role in this effort is to provide a fundamental basis from which the technology advances in propulsion can be derived. To fulfill this role, an integrated program was developed that focuses research efforts on key technical areas, provides students with a broad education in traditional propulsion-related science and engineering disciplines, and provides minority and other under-represented students with opportunities to take their first step toward professional careers in propulsion engineering. The program is made efficient by incorporating government propulsion laboratories and the U.S. propulsion industry into the program through extensive interactions and research involvement. The Center is comprised of faculty, professional staff, and graduate and undergraduate students working on a broad spectrum of research issues related to propulsion. The Center's research focus encompasses both current and advanced propulsion concepts for space transportation, with a research emphasis on liquid propellant rocket engines. The liquid rocket engine research includes programs in combustion and turbomachinery. Other space transportation modes that are being addressed include anti-matter, electric, nuclear, and solid propellant propulsion. Outside funding supports a significant fraction of Center research, with the major portion of the basic USERC grant being used for graduate student support and recruitment. The remainder of the USERC funds are used to support programs to increase minority student enrollment in engineering, to maintain Center infrastructure, and to develop research capability in key new areas. Significant research programs in propulsion systems for air and land transportation complement the space propulsion focus. The primary mission of the Center is student education. The student program emphasizes formal class work and research in classical engineering and science disciplines with applications to propulsion.

Mailman Segal Center for Human Development | NSU

Science.gov Websites

Dean Jim & Jan Moran Family Center Village Collaborations Early Learning Programs About Early Learning Programs Family Center Preschool About Our Preschool Enrollment Family Center Infant & Toddler - Advanced ABA M.S. in Developmental Disabilities - ABA Non-Degree Seeking - ABA & Advanced ABA Autism

Establishing a multidisciplinary academic cosmetic center.

PubMed

Rao, Venkat K; Schmid, Daniel B; Hanson, Summer E; Bentz, Michael L

2011-12-01

The demand for cosmetic services has risen rapidly in recent years, but has slowed down with the current economic downturn. Managed care organizations and Medicare have been steadily reducing their reimbursements for physician services. The payment for reconstructive surgical procedures has been decreasing and is likely to worsen with healthcare reform, and many plastic surgery residency programs are facing fiscal challenges. An adequate volume of patients needing cosmetic services is necessary to recruit and train the best candidates to the residency programs. Self-pay patients will help ensure the fiscal viability of plastic surgery residency programs. Attracting patients to an academic healthcare center will become more difficult in a recession without the appropriate facilities, programs, and pricing strategies. Setting up a modern cosmetic services program at an academic center has some unique challenges, including funding, academic politics, and turf. The authors opened a free-standing academic multidisciplinary center at their medical school 3 years ago. The center is an off-site, 13,000-sq ft facility that includes faculty from plastic surgery, ear, nose, and throat, dermatology, and vascular surgery. In this article, the authors discuss the process of developing and executing a plan for starting an aesthetic services center in an academic setting. The financing of the center and factors in pricing services are discussed. The authors show the impact of the center on their cosmetic surgery patient volumes, resident education, and finances. They expect that their experience will be helpful to other plastic surgery programs at academic medical centers.

Research and technology 1987 annual report of the Kennedy Space Center

NASA Technical Reports Server (NTRS)

1987-01-01

As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing increasing emphasis on the Center's research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of our current mission, we are developing the technological tools needed to execute the Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation, and is responsible for implementation of the majority of the projects of this Kennedy Space Center 1987 Annual Report.

Native Nutrition--Northwest Indian Treatment Center Honors Culture to Heal the Mind

ERIC Educational Resources Information Center

Krohn, Elise

2011-01-01

The Northwest Indian Treatment Center runs a 45-day inpatient treatment program in Elma, Washington. The Squaxin Island Tribe created the program to address an unmet need for culturally based drug and alcohol treatment centers for Indian people who grew up on reservations. The program specializes in treating people with chronic relapse patterns…

34 CFR 364.39 - What requirements apply to the administration of grants under the Centers for Independent Living...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What requirements apply to the administration of grants under the Centers for Independent Living program? 364.39 Section 364.39 Education Regulations of the..., DEPARTMENT OF EDUCATION STATE INDEPENDENT LIVING SERVICES PROGRAM AND CENTERS FOR INDEPENDENT LIVING PROGRAM...

34 CFR 364.39 - What requirements apply to the administration of grants under the Centers for Independent Living...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true What requirements apply to the administration of grants under the Centers for Independent Living program? 364.39 Section 364.39 Education Regulations of the..., DEPARTMENT OF EDUCATION STATE INDEPENDENT LIVING SERVICES PROGRAM AND CENTERS FOR INDEPENDENT LIVING PROGRAM...

76 FR 19655 - Medicare Program; Waiver Designs in Connection With the Medicare Shared Savings Program and the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... Savings Program and the Innovation Center AGENCY: Centers for Medicare & Medicaid Services (CMS) and...) of the Social Security Act (of the Act), as added by the Affordable Care Act (ACA) authorizes the... payment and service delivery models by the Center for Medicare and Medicaid Innovation. This notice with...

34 CFR 350.2 - What is the purpose of the Disability and Rehabilitation Research Project and Centers Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What is the purpose of the Disability and..., DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM General § 350.2 What is the purpose of the Disability and Rehabilitation Research Project and Centers Program? The...

77 FR 24628 - World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions...) to establish the World Trade Center (WTC) Health Program. Sections 3311, 3312, and 3321 of Title..., 2012. FOR FURTHER INFORMATION CONTACT: Roy M. Fleming, Sc.D., Senior Science Advisor, World Trade...

Self-Evaluation Handbook for Hotlines and Youth Crisis Centers.

ERIC Educational Resources Information Center

Baizerman, Michael; And Others

This handbook is a response to Hotline and Youth Crisis Center staff who asked for a guidebook for doing program evaluation. A cross-section of Hotline workers in three Minnesota centers was monitored to define issues and problems or concerns about their programs. The actual program methods used were determined and utilized to formalize a method…

The Prevalence of Anxiety and Pro-Social Behaviors in Child-Centered and Basic Skills Preschool Classrooms.

ERIC Educational Resources Information Center

Reio, Thomas G., Jr.; Maciolek, C. Lynn; Weiss, Erin M.

Although there is considerable evidence that kindergartners in child-centered programs have more opportunities to increase prosocial behavior and are more internally motivated than children in basic skills programs, the efficacy of child-centered versus basic skills programs with regard to prosocial behavior has not been examined among preschool…

South Carolina Center for Teacher Recruitment: 93-94 Annual Report.

ERIC Educational Resources Information Center

South Carolina Center for Teacher Recruitment, Rock Hill.

This report outlines and evaluates the 1993-94 accomplishments of the South Carolina Center for Teacher Recruitment and addresses future directions the Center and its programs will be taking. The main body of the document reports on the following programs: (1) Minority Teacher Recruitment; (2) ProTeam Program (to make minority students and young…

50 CFR 23.79 - How may I participate in the Plant Rescue Center Program?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false How may I participate in the Plant Rescue Center Program? 23.79 Section 23.79 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... may I participate in the Plant Rescue Center Program? (a) Purpose. We have established the Plant...

7 CFR 226.19 - Outside-school-hours care center provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-school-hours care centers shall be eligible to serve one or more of the following meal types: breakfasts...-hours care centers to serve Program meals to children on school vacation, including holidays and... care center participating in the Program shall claim only the meal types specified in its approved...

7 CFR 226.19 - Outside-school-hours care center provisions.

Code of Federal Regulations, 2011 CFR

2011-01-01

...-school-hours care centers shall be eligible to serve one or more of the following meal types: breakfasts...-hours care centers to serve Program meals to children on school vacation, including holidays and... care center participating in the Program shall claim only the meal types specified in its approved...

41 CFR 102-74.600 - Should Federal agencies utilize telework centers?

Code of Federal Regulations, 2011 CFR

2011-01-01

... utilize telework centers? 102-74.600 Section 102-74.600 Public Contracts and Property Management Federal... MANAGEMENT Telework § 102-74.600 Should Federal agencies utilize telework centers? Yes. In accordance with... flexiplace work telecommuting program (i.e., to pay telework center program user fees): (a) Department of...

41 CFR 102-74.600 - Should Federal agencies utilize telework centers?

Code of Federal Regulations, 2013 CFR

2013-07-01

... utilize telework centers? 102-74.600 Section 102-74.600 Public Contracts and Property Management Federal... MANAGEMENT Telework § 102-74.600 Should Federal agencies utilize telework centers? Yes. In accordance with... flexiplace work telecommuting program (i.e., to pay telework center program user fees): (a) Department of...

41 CFR 102-74.600 - Should Federal agencies utilize telework centers?

Code of Federal Regulations, 2012 CFR

2012-01-01

... utilize telework centers? 102-74.600 Section 102-74.600 Public Contracts and Property Management Federal... MANAGEMENT Telework § 102-74.600 Should Federal agencies utilize telework centers? Yes. In accordance with... flexiplace work telecommuting program (i.e., to pay telework center program user fees): (a) Department of...

41 CFR 102-74.600 - Should Federal agencies utilize telework centers?

Code of Federal Regulations, 2014 CFR

2014-01-01

... utilize telework centers? 102-74.600 Section 102-74.600 Public Contracts and Property Management Federal... MANAGEMENT Telework § 102-74.600 Should Federal agencies utilize telework centers? Yes. In accordance with... flexiplace work telecommuting program (i.e., to pay telework center program user fees): (a) Department of...

Center for Subsurface Sensing & Imaging Systems (CenSSIS)

Science.gov Websites

Contact Us Home Wavelets ALERT Center PROTECT Program Gordon Engineering Leadership Program Center Members Simon Pitts awarded 2015 Gordon Prize ALERT Center Director, Michael B. Silevitch and Gordon Engineering Leadership Director, Simon Pitts have been awarded the 2015 Bernard M. Gordon Prize for Engineering Education

CoRoT 101186644: A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

NASA Astrophysics Data System (ADS)

Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H. J.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

2013-05-01

We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (mV = 16) candidate revealed an eclipsing binary composed of a late F-type primary (Teff = 6090 ± 200 K) and a low-mass, dense late M-dwarf secondary on an eccentric (e = 0.4) orbit with a period of ~20.7 days. The M-dwarf has a mass of 0.096 ± 0.011 M⊙, and a radius of 0.104-0.006+0.026 R⊙, which possibly makes it the smallest and densest late M-dwarf reported so far. Unlike the claim that theoretical models predict radii that are 5-15% smaller than measured for low-mass stars, this one seems to have a radius that is consistent and might even be below the radius predicted by theoretical models. Based on observations made with the 1-m telescope at the Wise Observatory, Israel, the Swiss 1.2-m Leonhard Euler telescope at La Silla Observatory, Chile, the IAC-80 telescope at the Observatory del Teide, Canarias, Spain, and the 3.6-m telescope at La Silla Observatory (ESO), Chile (program 184.C-0639).

NASA Lewis Research Center/university graduate research program on engine structures

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

NASA Lewis Research Center established a graduate research program in support of the Engine Structures Research activities. This graduate research program focuses mainly on structural and dynamics analyses, computational mechanics, mechanics of composites and structural optimization. The broad objectives of the program, the specific program, the participating universities and the program status are briefly described.

NASA Lewis Research Center/University Graduate Research Program on Engine Structures

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

NASA Lewis Research Center established a graduate research program in support of the Engine Structures Research activities. This graduate research program focuses mainly on structural and dynamics analyses, computational mechanics, mechanics of composites and structural optimization. The broad objectives of the program, the specific program, the participating universities and the program status are briefly described.

A Peer-to-Peer Mentoring Program for In-Center Hemodialysis: A Patient-Centered Quality Improvement Program.

PubMed

St Clair Russell, Jennifer; Southerland, Shiree; Huff, Edwin D; Thomson, Maria; Meyer, Klemens B; Lynch, Janet R

2017-01-01

A patient-centered quality improvement program implemented in one Virginia hemodialysis facility sought to determine if peer-to-peer (P2P) programs can assist patients on in-center hemodialysis with self-management and improve outcomes. Using a single-arm, repeatedmeasurement, quasi-experimental design, 46 patients participated in a four-month P2P intervention. Outcomes include knowledge, self-management behaviors, and psychosocial health indicators: self-efficacy, perceived social support, hemodialysis social support, and healthrelated quality of life (HRQoL). Physiological health indicators included missed and shortened treatments, arteriovenous fistula placement, interdialytic weight gain, serum phosphorus, and hospitalizations. Mentees demonstrated increased knowledge, self-efficacy, perceived social support, hemodialysis social support, and HRQoL. Missed treatments decreased. Mentors experienced increases in knowledge, self-management, and social support. A P2P mentoring program for in-center hemodialysis can benefit both mentees and mentors. Copyright© by the American Nephrology Nurses Association.

Target marketing for the hospital-based wellness center.

PubMed

Cangelosi, J D

1997-01-01

The American population is aging, medical technology is advancing, and life expectancies are on the rise. At the same time hospitals are looking for additional sources of income due to the pressures of government regulations and managed care. One of the options for hospitals looking for additional sources of income is the hospital-based but free-standing comprehensive wellness and fitness center. Such centers go beyond the facilities, programs and services offered by traditional health and fitness centers. In addition to physical fitness programs, hospital-based wellness centers offer programs in CPR, nutrition, weight control and many other programs of interest to an aging but active American populace. This research documents the hospital industry, wellness industry and the prospects of success or failure for he hospital attempting such a venture. The focus of the research is the experience of a particular hospital with regard to the programs, facilities and services deemed most important by its target market.

Gifted Programs.

ERIC Educational Resources Information Center

Luehning, Barbara

1979-01-01

Describes programs for the gifted: visual and performing arts for secondary students, enrichment for rural elementary students, and a learning center elementary enrichment program. NOTE: includes "INTERARTS: The High School Program for the Talented in the Arts" by Barbara Luehning, "Spice" by Jane V. Salisbury, and "Learning Center Enrichment…

IARC - Illinois Accelerator Research Center | Pilot Program

Science.gov Websites

Toggle navigation Pilot Program Agenda Directions Registration Illinois Accelerator Research Center National Laboratory present Accelerator Stewardship Test Facility Pilot Program Use accelerator technology , energy and environment. With this pilot program, the DOE Office of Science National Laboratories are

Collaboration for prevention of chronic disease in Kentucky: the Health Education Through Extension Leaders (HEEL) program.

PubMed

Riley, Peggy

2008-09-01

Health Education Through Extension Leaders (HEEL) is one of the solutions the University of Kentucky College of Agriculture has created to address the problem of chronic disease in Kentucky. Building on the land grant model for education, outreach, and prevention, HEEL collaborates and partners with the academic health centers, area health education centers, the Center for Rural Health, the Kentucky Cancer Program, the Markey Cancer Center, the University of Kansas Wellness Program, and the Kentucky Cabinet for Health and Family Services to implement research-based preventive programs to the county extension agents across Kentucky. Extension agents are an instrumental bridge between the communities across Kentucky and the educational resources provided by the HEEL program.

Data Center Energy Practitioner (DCEP) Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Traber, Kim; Salim, Munther; Sartor, Dale A.

2016-02-02

The main objective for the DCEP program is to raise the standards of those involved in energy assessments of data centers to accelerate energy savings. The program is driven by the fact that significant knowledge, training, and skills are required to perform accurate energy assessments. The program will raise the confidence level in energy assessments in data centers. For those who pass the exam, the program will recognize them as Data Center Energy Practitioners (DCEPs) by issuing a certificate. Hardware req.: PC, MAC; Software Req.: Windows; Related/Auxiliary software--MS Office; Type of files: executable modules, user guide; Documentation: e-user manual; Documentation:more » http://www.1.eere.energy.gov/industry/datacenters/ 12/10/15-New Documentation URL: https://datacenters.lbl.gov/dcep« less

Research and technology

NASA Technical Reports Server (NTRS)

1986-01-01

As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing increasing emphasis on the Center's research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of our current mission, we are developing the technological tools needed to execute the Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation, and is responsible for implementation of the majority of the projects in this Kennedy Space Center 1986 Annual Report.

Aphasia centers in North America: a survey.

PubMed

Simmons-Mackie, Nina; Holland, Audrey L

2011-08-01

There is a growing trend toward dedicated programs designed to improve the lives of people with aphasia and their families. We are referring to these programs collectively as "aphasia centers." These programs purportedly differ from more traditional medically based aphasia rehabilitation. However, there is no directory of aphasia centers and no definition of what constitutes such a program. Therefore, an online survey was designed to identify and describe aphasia centers in the United States and Canada. A 37-question survey was posted online via SurveyMonkey. An introductory letter was distributed by electronic mail to a listserv and mailing lists of programs associated with aphasia. Potential respondents who considered themselves an aphasia center were asked to complete the survey. A total of 33 survey responses were analyzed, and descriptive data were compiled resulting in a description of the following aspects of aphasia centers: demographic information, mission, admission and discharge policies, assessment practices, program logistics, staffing patterns, marketing, funding, and services offered. In addition, a qualitative analysis of written text responses revealed the following key themes that appear to characterize the responding programs: services that differ from traditional aphasia rehabilitation; a sense of community; a holistic focus on quality of life, psychosocial well-being, participation, and social support; the centrality of group interaction; and variety/intensity of services. © Thieme Medical Publishers.

Space Operations Center system analysis study extension. Volume 2: Programmatics and cost

NASA Technical Reports Server (NTRS)

1982-01-01

A summary of Space Operations Center (SOC) orbital space station costs, program options and program recommendations is presented. Program structure, hardware commonality, schedules and program phasing are considered. Program options are analyzed with respect to mission needs, design and technology options, and anticipated funding constraints. Design and system options are discussed.

NDEA Language and Area Centers: A Report on the First Five Years.

ERIC Educational Resources Information Center

Bigelow, Donald N.; Legters, Lyman H.

This report documents a broad category of information concerning the first five years of the National Defense Education Act of 1958. Included in the report are the following chapters: (1) concept and practice in non-western area studies, (2) the language and area centers program, (3) impact of the centers program, (4) outlook for the program, and…

75 FR 44231 - Notice of Proposed Extension of Project Period and Waiver for the State and Federal Policy Forum...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-28

... and Federal Policy Forum for Program Improvement Center (CFDA No. 84.326F) AGENCY: Office of Special... Program Improvement Center (CFDA No. 84.326F). SUMMARY: The Secretary proposes to waive the requirements... waiver would enable the currently funded State and Federal Policy Forum for Program Improvement Center to...

MSFC Space Station Program Commonly Used Acronyms and Abbreviations Listing

NASA Technical Reports Server (NTRS)

Gates, Thomas G.

1988-01-01

The Marshall Space Flight Center maintains an active history program to assure that the foundation of the Center's history is captured and preserved for current and future generations. As part of that overall effort, the Center began a project in 1987 to capture historical information and documentation on the Marshall Center's roles regarding Space Shuttle and Space Station. This document is MSFC Space Station Program Commonly Used Acronyms and Abbreviations Listing. It contains acronyms and abbreviations used in Space Station documentation and in the Historian Annotated Bibliography of Space Station Program. The information may be used by the researcher as a reference tool.

Centering Faith-Based Identities in Collaborative Contexts: Critically Prophetic Action at the Robinson Community Learning Center

ERIC Educational Resources Information Center

Miller, Peter M.; Caponigro, Jay; Tyson, Luther

2008-01-01

This paper examines the working philosophy of a university-community collaborative program--the Robinson Community Learning Center (RCLC), a multifaceted community service center located in the Northeast Neighborhood of South Bend, Indiana, in the United States. This program's multitude of educational and social services includes individualized…

76 FR 60050 - Medicaid Program: Money Follows the Person Rebalancing Demonstration Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services Medicaid Program: Money Follows the Person Rebalancing Demonstration Program AGENCY: Centers for Medicare & Medicaid..., particularly given the complexity and vulnerability of the populations being served in MFP and the Congress...

Alternative Fuels Data Center: City of Chicago Program Encourages Petroleum

Science.gov Websites

Displacement and Collaboration Between Departments City of Chicago Program Encourages Petroleum : City of Chicago Program Encourages Petroleum Displacement and Collaboration Between Departments on Facebook Tweet about Alternative Fuels Data Center: City of Chicago Program Encourages Petroleum

Pioneering quality assessment in European cancer centers: a data analysis of the organization for European cancer institutes accreditation and designation program.

PubMed

Saghatchian, Mahasti; Thonon, Frédérique; Boomsma, Femke; Hummel, Henk; Koot, Bert; Harrison, Chris; Rajan, Abinaya; de Valeriola, Dominique; Otter, Renée; Laranja Pontes, José; Lombardo, Claudio; McGrath, Eoin; Ringborg, Ulrik; Tursz, Thomas; van Harten, Wim

2014-09-01

In order to improve the quality of care in Cancer Centers (CC) and designate Comprehensive Cancer Centers (CCCs), the Organization for European Cancer Institutes (OECI) launched an Accreditation and Designation (A&D) program. The program facilitates the collection of defined data and the assessment of cancer center quality. This study analyzes the results of the first 10 European centers that entered the program. The assessment included 927 items divided across qualitative and quantitative questionnaires. Data collected during self-assessment and peer-review from the 10 first participating centers were combined in a database for comparative analysis using simple statistics. Quantitative and qualitative results were validated by auditors during the peer review visits. Volumes of various functions and activities dedicated to care, research, and education varied widely among centers. There were no significant differences in resources for radiology, radiotherapy, pathologic diagnostic, and surgery. Differences were observed in the use of clinical pathways but not for the practices of holding multidisciplinary team meetings and conforming to guidelines. Regarding human resources, main differences were in the composition and number of supportive care and research staff. All 10 centers applied as CCCs; five obtained the label, and five were designated as CCs. The OECI A&D program allows comparisons between centers with regard to management, research, care, education, and designation as CCs or CCCs. Through the peer review system, recommendations for improvements are given. Assessing the added value of the program, as well as research and patient treatment outcomes, is the next step. Copyright © 2014 by American Society of Clinical Oncology.

Kennedy Space Center Director Update

NASA Image and Video Library

2014-03-06

CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Attendees mingled and visited various displays, including Ground Systems Development and Operations Program and Education Office displays. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper

Kennedy Space Center Director Update

NASA Image and Video Library

2014-03-06

CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. An attendee talks with Scott Thurston, Kennedy deputy of the spacecraft office at the Commercial Crew Program display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper

Efficient management of cardiovascular risk screening programs

NASA Technical Reports Server (NTRS)

Roth, Carol

1993-01-01

The Environmental Health Unit, located on-site at the the Goddard Space Flight Center (GSFC), is responsible for the implementation of the Center's Employee Environmental and Occupational Health Program. The Health Unit, Health Physics (HP), and Industrial Hygiene (IH) staffs collaborate to provide quality service to the employees at GSFC. The Health Unit staff identifies, evaluates, and ensures the control of occupational hazards on the Center. In the past, components of the Industrial Hygiene Program have included the Industrial Hygiene Health Hazard Identification Program (IHHIP), the Hearing Conservation Program (HCP), the Hazard Communication Program, and the bi-annual fume hood survey. More recently, the Environmental Health Unit has expanded its services by adding the Ergonomics Program. Various aspects of the Ergonomics Program are discussed.

Summer High School Apprenticeship Research Program (SHARP)

NASA Technical Reports Server (NTRS)

1997-01-01

The summer of 1997 will not only be noted by NASA for the mission to Mars by the Pathfinder but also for the 179 brilliant apprentices that participated in the SHARP Program. Apprentice participation increased 17% over last year's total of 153 participants. As indicated by the End-of-the-Program Evaluations, 96% of the programs' participants rated the summer experience from very good to excellent. The SHARP Management Team began the year by meeting in Cocoa Beach, Florida for the annual SHARP Planning Conference. Participants strengthened their Education Division Computer Aided Tracking System (EDCATS) skills, toured the world-renowned Kennedy Space Center, and took a journey into space during the Alien Encounter Exercise. The participants returned to their Centers with the same goals and objectives in mind. The 1997 SHARP Program goals were: (1) Utilize NASA's mission, unique facilities and specialized workforce to provide exposure, education, and enrichment experiences to expand participants' career horizons and inspire excellence in formal education and lifelong learning. (2) Develop and implement innovative education reform initiatives which support NASA's Education Strategic Plan and national education goals. (3) Utilize established statistical indicators to measure the effectiveness of SHARP's program goals. (4) Explore new recruiting methods which target the student population for which SHARP was specifically designed. (5) Increase the number of participants in the program. All of the SHARP Coordinators reported that the goals and objectives for the overall program as well as their individual program goals were achieved. Some of the goals and objectives for the Centers were: (1) To increase the students' awareness of science, mathematics, engineering, and computer technology; (2) To provide students with the opportunity to broaden their career objectives; and (3) To expose students to a variety of enrichment activities. Most of the Center goals and objectives were consistent with the overall program goals. Modem Technology Systems, Inc., was able to meet the SHARP Apprentices, Coordinators and Mentors during their site visits to Stennis Space Center, Ames Research Center and Dryden Flight Research Center. All three Centers had very efficient programs and adhered to SHARP's general guidelines and procedures. MTSI was able to meet the apprentices from the other Centers via satellite in July during the SHARP Video-Teleconference(ViTS). The ViTS offered the apprentices and the NASA and SHARP Coordinators the opportunity to introduce themselves. The apprentices from each Center presented topical "Cutting Edge Projects". Some of the accomplishments for the 1997 SHARP Program year included: MTSI hiring apprentices from four of the nine NASA Centers, the full utilization of the EDCATS by apprentices and NASA/SHARP Coordinators, the distribution of the SHARP Apprentice College and Scholarship Directory, a reunion with former apprentices from Langley Research Center and the development of a SHARP Recruitment Poster. MTSI developed another exciting newsletter containing graphics and articles submitted by the apprentices and the SHARP Management Team.

78 FR 69173 - University Transportation Centers Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration University... University Transportation Centers (UTCs) program. Funds for this grant program are authorized beginning on..., technology and education resources, leadership, multi-modal research capability, and commitment to...

Summer Research Program - 1997 Summer Faculty Research Program Volume 6 Arnold Engineering Development Center United States Air Force Academy Air Logistics Centers

DTIC Science & Technology

1997-12-01

Fracture Analysis of the F-5, 15%-Spar Bolt DR Devendra Kumar SAALC/LD 6- 16 CUNY-City College, New York, NY A Simple, Multiversion Concurrency Control...Program, University of Dayton, Dayton, OH. [3]AFGROW, Air Force Crack Propagation Analysis Program, Version 3.82 (1997) 15-8 A SIMPLE, MULTIVERSION ...Office of Scientific Research Boiling Air Force Base, DC and San Antonio Air Logistic Center August 1997 16-1 A SIMPLE, MULTIVERSION CONCURRENCY

Inmate Education: The Virginia Model.

ERIC Educational Resources Information Center

Gendron, Dennis; Cavan, John

Southside Virginia Community College (SVCC) operates the largest inmate education program in Virginia, offering associate degree programs and academic support at three correctional centers and plannning programs at two others. The program at Mecklenburg Correctional Center, which has the reputation for being one of the country's toughest prisons,…

Aeroacoustics Research Program in JIAFS

NASA Technical Reports Server (NTRS)

Myers, Michael K.

2000-01-01

This paper presents a final report on Aeroacoustics Research Program in JIAFS (Joint Institute For Advancement of Flight Sciences). The objectives of the program were to conduct research at the NASA Langley Research Center and to provide a comprehensive education program at the Center leading to advanced degrees in aeroacoustics.

Can Jupiters be found by monitoring Galactic bulge microlensing events from northern sites?

NASA Astrophysics Data System (ADS)

Tsapras, Yiannis; Street, Rachel A.; Horne, Keith; Penny, Alan; Clarke, Fraser; Deeg, Hans; Garzon, Francisco; Kemp, Simon; Zapatero Osorio, Maria Rosa; Oscoz, Alejandro Abad; Sanchez, Santiago Madruga; Eiroa, Carlos; Mora, Alcione; Alberdi, Antxon; Collier Cameron, Andrew; Davies, John K.; Ferlet, Roger; Grady, Carol; Harris, Allan W.; Palacios, Javier; Quirrenbach, Andreas; Rauer, Heike; Schneider, Jean; de Winter, Dolf; Merin, Bruno; Solano, Enrique

2001-08-01

In 1998 the EXPORT team monitored microlensing event light curves using a charge-coupled device (CCD) camera on the IACQ4 0.8-m telescope on Tenerife to evaluate the prospect of using northern telescopes to find microlens anomalies that reveal planets orbiting the lens stars. The high airmass and more limited time available for observations of Galactic bulge sources make a northern site less favourable for microlensing planet searches. However, there are potentially a large number of northern 1-m class telescopes that could devote a few hours per night to monitor ongoing microlensing events. Our IAC observations indicate that accuracies sufficient to detect planets can be achieved despite the higher airmass.

Friendship IAP, Maryland. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-05-04

USAFETAC PSYCHROMETRIC SUMMARY’k A1 dEATHER SERVXCE/MAC STATIO STATION 041A vt LS MONT. PAGE I1 - i(Fl WI~III~i~i1IIi ET SUL& TESIPEXATUnE DEPRESION (F...WEATHER SERVICE/MAC L2AD0. FRIENDOSHIP IAP MD 74-S1orf STATION STATION *464 VtAAS M. PAGE 2 -nn-nn Th.~.WIT SUL$ TEMPERATURE DEPRESION (F) ITOTAL TOTAL () 0...Alte WEAT.4ER SERVICE/IAC 776ff F7hnSHTP Ti A mn-t ER STAION NWA YA PAGE 1 WE? BULB TEMPERATURE DEPRESION (F) TOTAL 1 TOTAL (I 0 1.2 j3-43. 7. 9. . 1o 1

Research and technology

NASA Technical Reports Server (NTRS)

1988-01-01

As the NASA Center responsible for assembly, checkout, servicing, launch, recovery and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing emphasis on its research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of our current mission, we are developing the technological tools needed to execute the Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation, and is responsible for implementation of the majority of the projects in this Kennedy Space Center 1988 Annual Report.

The Center for the Study of Social Organization of Schools and the Learning Process. Third Annual Report.

ERIC Educational Resources Information Center

McDill, Edward L.; And Others

A basic overview of Research and Development (R and D) Centers programs, and the various larger institutions of which they are a part, is given. The administrative and program structure of the Johns Hopkins R and D Center follows, with an organizational chart, staff list, and a program and project register included. A descriptive overview of the…

An illustrated chronology of the NASA Marshall Center and MSFC programs 1960-1973

NASA Technical Reports Server (NTRS)

Akens, D. S.

1974-01-01

The role that NASA's Marshall Space Flight Center played in the space program during the past 13 years is highlighted with pictures and text, plus background information concerning events that were important in the center's formation.

Kennedy Space Center Director Update

NASA Image and Video Library

2014-03-06

CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. From left, Scott Thurston, Kennedy deputy of the spacecraft office of the Commercial Crew Program, talks with Scott Colloredo, director of the Center Planning and Development Directorate. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper

The Lederman Science Center: Past, Present, Future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bardeen, Marjorie G.; /Fermilab

2011-11-01

For 30 years, Fermilab has offered K-12 education programs, building bridges between the Lab and the community. The Lederman Science Center is our home. We host field trips and tours, visit schools, offer classes and professional development workshops, host special events, support internships and have a strong web presence. We develop programs based on identified needs, offer programs with peer-leaders and improve programs from participant feedback. For some we create interest; for others we build understanding and develop relationships, engaging participants in scientific exploration. We explain how we created the Center, its programs, and what the future holds.

The Lederman Science Center:. Past, Present, Future

NASA Astrophysics Data System (ADS)

Bardeen, Marjorie G.

2012-08-01

For 30 years, Fermilab has offered K-12 education programs, building bridges between the Lab and the community. The Lederman Science Center is our home. We host field trips and tours, visit schools, offer classes and professional development workshops, host special events, support internships and have a strong web presence. We develop programs based on identified needs, offer programs with peer-leaders and improve programs from participant feedback. For some we create interest; for others we build understanding and develop relationships, engaging participants in scientific exploration. We explain how we created the Center, its programs, and what the future holds.

34 CFR 644.1 - What is the Educational Opportunity Centers program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Educational Opportunity Centers program? 644.1 Section 644.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION EDUCATIONAL OPPORTUNITY CENTERS General § 644.1 What is the Educational Opportunity Centers...

The Louisiana State University Law Center's Bijural Program.

ERIC Educational Resources Information Center

Costonis, John J.

2002-01-01

Describes the bijural program of Louisiana State University Law Center. The program educates all first-degree law students in both the common law and civil law traditions, preparing them for the increasing globalization of legal practice. (EV)

Overlay field application program, Pennsylvania US-119.

DOT National Transportation Integrated Search

2010-11-01

The Concrete Overly Filed Application program is administered by FHWA and the National Concrete Pavement Technology Center (CP Tech Center). The overall objective of this program is to increase the awareness and knowledge of concrete overlay applicat...

Initiation and Maintenance of Fitness Center Utilization in an Incentive-Based Employer Wellness Program

PubMed Central

Abraham, Jean Marie; Crespin, Daniel; Rothman, Alexander

2015-01-01

Objective Investigate the initiation and maintenance of participation in an employer-based wellness program that provides financial incentives for fitness center utilization. Methods Using multivariate analysis, we investigated how employees’ demographics, health status, exercise-related factors, and lifestyle change preferences affect program participation. Results Forty-two percent of eligible employees participated in the program and 24% earned a $20 incentive at least once by utilizing a gym 8 times or more in a month. On average, participants utilized fitness centers 7.0 months each year and earned credit 4.5 months. Participants’ utilization diminished after their first year in the program. Conclusions Factors associated with initiation and maintenance of fitness center utilization were similar. Declining utilization over time raises concern about the long-run effectiveness of fitness-focused wellness programs. Employers may want to consider additional levers to positively reinforce participation. PMID:26340283

Geriatric resources in acute care hospitals and trauma centers: a scarce commodity.

PubMed

Maxwell, Cathy A; Mion, Lorraine C; Minnick, Ann

2013-12-01

The number of older adults admitted to acute care hospitals with traumatic injury is rising. The purpose of this study was to examine the location of five prominent geriatric resource programs in U.S. acute care hospitals and trauma centers (N = 4,865). As of 2010, 5.8% of all U.S. hospitals had at least one of these programs. Only 8.8% of trauma centers were served by at least one program; the majorities were in level I trauma centers. Slow adoption of geriatric resource programs in hospitals may be due to lack of champions who will advocate for these programs, lack of evidence of their impact on outcomes, or lack of a business plan to support adoption. Future studies should focus on the benefits of geriatric resource programs from patients' perspectives, as well as from business case and outcomes perspectives. Copyright 2013, SLACK Incorporated.

Implementing an Evidence-Based Fall Prevention Intervention in Community Senior Centers.

PubMed

Li, Fuzhong; Harmer, Peter; Fitzgerald, Kathleen

2016-11-01

To evaluate the impact of implementing an evidence-based fall prevention intervention in community senior centers. We used a single-group design to evaluate the Tai Ji Quan: Moving for Better Balance (TJQMBB) program's adoption, population reach, implementation, effectiveness, and maintenance among 36 senior centers in 4 Oregon counties between 2012 and 2016. The primary outcome measure, as part of the effectiveness evaluation, was number of falls as ascertained by self-report. Trained TJQMBB instructors delivered the program to community-dwelling older adults for 48 weeks, with a 6-month postintervention follow-up. TJQMBB was adopted by 89% of the senior centers approached and reached 90% of the target population. The program resulted in a 49% reduction in the total number of falls and improved physical performance. Participation was well maintained after the program's completion. The average cost-effectiveness ratio for the 48-week program implementation was $917 per fall prevented and $676 per fall prevented for multiple falls. TJQMBB is an effective public health program that can be broadly implemented in community senior centers for primary prevention of falls among community-dwelling older adults.

Apollo Program Leadership

NASA Technical Reports Server (NTRS)

1950-01-01

This historical photograph is of the Apollo Space Program Leaders. An inscription appears at the top of the image that states, 'Our deep appreciation for your outstanding contribution to the success of Apollo 11', signed 'S', indicating that it was originally signed by Apollo Program Director General Sam Phillips, pictured second from left. From left to right are; NASA Associate Administrator George Mueller; Phillips; Kurt Debus, Director of the Kennedy Space Center; Robert Gilruth, Director of the Manned Spacecraft Center, later renamed the Johnson Space Center; and Wernher von Braun, Director of the Marshall Space Flight Center.