The Impact of Meaning and Dimensionality on Copying Accuracy in Individuals with Autism

ERIC Educational Resources Information Center

Sheppard, Elizabeth; Ropar, Danielle; Mitchell, Peter

2007-01-01

Weak Central Coherence (Frith, 1989) predicts that, in autism, perceptual processing is relatively unaffected by conceptual analysis. Enhanced Perceptual Functioning (Mottron & Burack, 2001) predicts that the perceptual processing of those with autism is less influenced by conceptual analysis only when higher-level processing is detrimental to…

Assessing Cultural Change in North-Central New Mexico.

ERIC Educational Resources Information Center

Eastman, Clyde

A study conducted during the summer of 1969 researched the concept of culture with regard to the acculturation process of Spanish Americans. The Spanish Americans of north-central New Mexico were compared with the Anglo Americans living within that region. Data were collected on 799 adults from the 2 groups by means of personal interviews. Factor…

7 CFR 1421.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... such system; or (3) Other such acceptable evidence of title, as determined by CCC. Wool means the fiber... bundled peanut MALs and LDPs to a DMA. In the absence of a centralized MAL and LDP processing system for... accounting systems. Designated Marketing Association (DMA) means an entity, or a subsidiary thereof, that...

7 CFR 1421.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... such system; or (3) Other such acceptable evidence of title, as determined by CCC. Wool means the fiber... bundled peanut MALs and LDPs to a DMA. In the absence of a centralized MAL and LDP processing system for... accounting systems. Designated Marketing Association (DMA) means an entity, or a subsidiary thereof, that...

Central tendency effects in time interval reproduction in autism

PubMed Central

Karaminis, Themelis; Cicchini, Guido Marco; Neil, Louise; Cappagli, Giulia; Aagten-Murphy, David; Burr, David; Pellicano, Elizabeth

2016-01-01

Central tendency, the tendency of judgements of quantities (lengths, durations etc.) to gravitate towards their mean, is one of the most robust perceptual effects. A Bayesian account has recently suggested that central tendency reflects the integration of noisy sensory estimates with prior knowledge representations of a mean stimulus, serving to improve performance. The process is flexible, so prior knowledge is weighted more heavily when sensory estimates are imprecise, requiring more integration to reduce noise. In this study we measure central tendency in autism to evaluate a recent theoretical hypothesis suggesting that autistic perception relies less on prior knowledge representations than typical perception. If true, autistic children should show reduced central tendency than theoretically predicted from their temporal resolution. We tested autistic and age- and ability-matched typical children in two child-friendly tasks: (1) a time interval reproduction task, measuring central tendency in the temporal domain; and (2) a time discrimination task, assessing temporal resolution. Central tendency reduced with age in typical development, while temporal resolution improved. Autistic children performed far worse in temporal discrimination than the matched controls. Computational simulations suggested that central tendency was much less in autistic children than predicted by theoretical modelling, given their poor temporal resolution. PMID:27349722

DNA → RNA: What Do Students Think the Arrow Means?

PubMed

Wright, L Kate; Fisk, J Nick; Newman, Dina L

2014-01-01

The central dogma of molecular biology, a model that has remained intact for decades, describes the transfer of genetic information from DNA to protein though an RNA intermediate. While recent work has illustrated many exceptions to the central dogma, it is still a common model used to describe and study the relationship between genes and protein products. We investigated understanding of central dogma concepts and found that students are not primed to think about information when presented with the canonical figure of the central dogma. We also uncovered conceptual errors in student interpretation of the meaning of the transcription arrow in the central dogma representation; 36% of students (n = 128; all undergraduate levels) described transcription as a chemical conversion of DNA into RNA or suggested that RNA existed before the process of transcription began. Interviews confirm that students with weak conceptual understanding of information flow find inappropriate meaning in the canonical representation of central dogma. Therefore, we suggest that use of this representation during instruction can be counterproductive unless educators are explicit about the underlying meaning. © 2014 L. K. Wright et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Meaning Making in the Context of Disasters.

PubMed

Park, Crystal L

2016-12-01

Understanding the factors underlying adaptive psychological responses and recovery after disasters has important implications for intervention and prevention efforts. To date, little attention has been paid to successful coping processes in recovering from natural and technological disasters. This article takes a meaning making perspective to explicate how survivors successfully adapt after disasters. Relevant literature is reviewed to illustrate the process of adaptation and resilience after disasters. Studies to date suggest both survivors' global meaning, particularly their religiousness and sense of meaning, and their appraisals and meaning making after the disaster are important influences on their postdisaster resilience. Meanings made in the form of changes in global beliefs and perceived growth have been reported and shown to have inconsistent relations with adjustment. Although much more research is needed, current literature suggests that meaning making processes are central to recovery and resilience after a range of disasters. © 2016 Wiley Periodicals, Inc.

Meanings, mechanisms, and measures of holistic processing.

PubMed

Richler, Jennifer J; Palmeri, Thomas J; Gauthier, Isabel

2012-01-01

Few concepts are more central to the study of face recognition than holistic processing. Progress toward understanding holistic processing is challenging because the term "holistic" has many meanings, with different researchers addressing different mechanisms and favoring different measures. While in principle the use of different measures should provide converging evidence for a common theoretical construct, convergence has been slow to emerge. We explore why this is the case. One challenge is that "holistic processing" is often used to describe both a theoretical construct and a measured effect, which may not have a one-to-one mapping. Progress requires more than greater precision in terminology regarding different measures of holistic processing or different hypothesized mechanisms of holistic processing. Researchers also need to be explicit about what meaning of holistic processing they are investigating so that it is clear whether different researchers are describing the same phenomenon or not. Face recognition differs from object recognition, and not all meanings of holistic processing are equally suited to help us understand that important difference.

A Languacognitive Constructionist Approach to Intercultural Competence in Educational Settings

ERIC Educational Resources Information Center

Strugielska, Ariadna; Piatkowska, Katarzyna

2017-01-01

The aim of this paper is to discuss intercultural competence (IC) from a languacognitive perspective, whose main assumption is the interface between language, cognition and culture manifested in meaning construction. The article first emphasizes the centrality of language in the process of meaning construction. As a result, in the following…

Reading Comprehension in Children with ADHD: Cognitive Underpinnings of the Centrality Deficit

PubMed Central

Miller, Amanda C.; Keenan, Janice M.; Betjemann, Rebecca S.; Willcutt, Erik; Pennington, Bruce F.; Olson, Richard K.

2012-01-01

We examined reading comprehension in children with ADHD by assessing their ability to build a coherent mental representation that allows them to recall central and peripheral information. We compared children with ADHD (mean age 9.78) to word reading-matched controls (mean age 9.89) on their ability to retell a passage. We found that even though children with ADHD recalled more central than peripheral information, they showed their greatest deficit, relative to controls, on central information – a centrality deficit (Miller & Keenan, 2009). We explored the cognitive underpinnings of this deficit using regressions to compare how well cognitive factors (working memory, inhibition, processing speed, and IQ) predicted the ability to recall central information, after controlling for word reading ability, and whether these cognitive factors interacted with ADHD symptoms. Working memory accounted for the most unique variance. Although previous evidence for reading comprehension difficulties in children with ADHD have been mixed, this study suggests that even when word reading ability is controlled, children with ADHD have difficulty building a coherent mental representation, and this difficulty is likely related to deficits in working memory. PMID:23054132

Integrating Micro-computers with a Centralized DBMS: ORACLE, SEED AND INGRES

NASA Technical Reports Server (NTRS)

Hoerger, J.

1984-01-01

Users of ADABAS, a relational-like data base management system (ADABAS) with its data base programming language (NATURAL) are acquiring microcomputers with hopes of solving their individual word processing, office automation, decision support, and simple data processing problems. As processor speeds, memory sizes, and disk storage capacities increase, individual departments begin to maintain "their own" data base on "their own" micro-computer. This situation can adversely affect several of the primary goals set for implementing a centralized DBMS. In order to avoid this potential problem, these micro-computers must be integrated with the centralized DBMS. An easy to use and flexible means for transferring logic data base files between the central data base machine and micro-computers must be provided. Some of the problems encounted in an effort to accomplish this integration and possible solutions are discussed.

Narrative comprehension in 4-7-year-old children with autism: testing the Weak Central Coherence account.

PubMed

Nuske, Heather Joy; Bavin, Edith L

2011-01-01

Despite somewhat spared structural language development in high-functioning autism, communicative comprehension deficits persist. Comprehension involves the integration of meaning: global processing is required. The Weak Central Coherence theory suggests that individuals with autism are biased to process information locally. This cognitive style may impair comprehension, particularly if inferencing is required. However, task performance may be facilitated by this cognitive style if local processing is required. The current study was designed to examine the extent to which the 'weak central coherence' cognitive style affects comprehension and inferential processing of spoken narratives. The children with autism were expected to perform comparatively poorer on inferences relating to event scripts and comparatively better on inferences requiring deductive reasoning. Fourteen high-functioning children with autism were recruited from databases of various autism organizations (mean age = 6:7, 13 males, one female) and were matched on a receptive vocabulary and a picture-completion task with 14 typically developing children recruited from a local childcare centre (mean age = 4:10, seven males, seven females). The children were read short stories and asked questions about the stories. Results indicated that the children with autism were less able to make inferences based on event scripts, but the groups did not differ significantly on inferences requiring deductive logical reasoning. Despite similar group performance on questions relating to the main idea of the stories, only for the typically developing group was good performance on extracting the main idea of the narratives significantly correlated with performance on all other comprehension tasks. Findings provide some support for the Weak Central Coherence theory and demonstrate that young children with autism do not spontaneously integrate information in order to make script inferences, as do typically developing children. These findings may help to explain communicative problems of young children with autism and can be applied to intervention programme development. More research on the link between a 'weak central coherence' cognitive style and communicative comprehension in autism will be valuable in understanding the comprehension deficits associated with autism. © 2010 Royal College of Speech & Language Therapists.

40 CFR 63.161 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... good engineering judgement and standards, such as ANSI B31-3. In food/medical service means that a... manufacture a Food and Drug Administration regulated product where leakage of a barrier fluid into the process..., storage at the chemical manufacturing process unit to which the records pertain, or storage in central...

Meanings, Mechanisms, and Measures of Holistic Processing

PubMed Central

Richler, Jennifer J.; Palmeri, Thomas J.; Gauthier, Isabel

2012-01-01

Few concepts are more central to the study of face recognition than holistic processing. Progress toward understanding holistic processing is challenging because the term “holistic” has many meanings, with different researchers addressing different mechanisms and favoring different measures. While in principle the use of different measures should provide converging evidence for a common theoretical construct, convergence has been slow to emerge. We explore why this is the case. One challenge is that “holistic processing” is often used to describe both a theoretical construct and a measured effect, which may not have a one-to-one mapping. Progress requires more than greater precision in terminology regarding different measures of holistic processing or different hypothesized mechanisms of holistic processing. Researchers also need to be explicit about what meaning of holistic processing they are investigating so that it is clear whether different researchers are describing the same phenomenon or not. Face recognition differs from object recognition, and not all meanings of holistic processing are equally suited to help us understand that important difference. PMID:23248611

Reading for Meaning: Reading Comprehension Skills in ASD and the Role of Oral Language, Central Coherence, and Executive Function

ERIC Educational Resources Information Center

Davidson, Meghan M.

2016-01-01

Reading comprehension is a complex interactional process whereby the accumulated meaning of sounds, words, and sentences is integrated to form a meaningful representation of text. It is well established that many individuals with autism spectrum disorder (ASD) have reading comprehension difficulties, but less is understood about the underlying…

Rhetorical Analysis of Teaching Process in Selected English Classes: Methods and Implications.

ERIC Educational Resources Information Center

Lindley, Daniel Allen, Jr.

This study related selected principles of rhetorical analysis to teaching as it actually occurs in the classroom. The Aristotelian definition of rhetoric as the means of discovering all the available means of persuasion is central to teaching, in that the entire endeavor of education rests upon the premise that children, as they grow, need and…

The weak coherence account: detail-focused cognitive style in autism spectrum disorders.

PubMed

Happé, Francesca; Frith, Uta

2006-01-01

"Weak central coherence" refers to the detail-focused processing style proposed to characterise autism spectrum disorders (ASD). The original suggestion of a core deficit in central processing resulting in failure to extract global form/meaning, has been challenged in three ways. First, it may represent an outcome of superiority in local processing. Second, it may be a processing bias, rather than deficit. Third, weak coherence may occur alongside, rather than explain, deficits in social cognition. A review of over 50 empirical studies of coherence suggests robust findings of local bias in ASD, with mixed findings regarding weak global processing. Local bias appears not to be a mere side-effect of executive dysfunction, and may be independent of theory of mind deficits. Possible computational and neural models are discussed.

Stochastic differential equation model for linear growth birth and death processes with immigration and emigration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Granita, E-mail: granitafc@gmail.com; Bahar, A.

This paper discusses on linear birth and death with immigration and emigration (BIDE) process to stochastic differential equation (SDE) model. Forward Kolmogorov equation in continuous time Markov chain (CTMC) with a central-difference approximation was used to find Fokker-Planckequation corresponding to a diffusion process having the stochastic differential equation of BIDE process. The exact solution, mean and variance function of BIDE process was found.

Untangling the roles of wind, run-off and tides in Prince William Sound

NASA Astrophysics Data System (ADS)

Colas, François; Wang, Xiaochun; Capet, Xavier; Chao, Yi; McWilliams, James C.

2013-07-01

Prince William Sound (PWS) oceanic circulation is driven by a combination of local wind, large run-off and strong tides. Using a regional oceanic model of the Gulf of Alaska, adequately resolving the mean circulation and mesoscale eddies, we configure a series of three nested domains. The inner domain zooms in on Prince William Sound with a 1-km horizontal grid resolution. We analyze a set of four experiments with different combinations of run-off, wind and tides to demonstrate the relative influence of these forcing on the central Sound mean circulation cell and its seasonal variability. The mean circulation in the central PWS region is generally characterized by a cyclonic cell. When forced only by the wind, the circulation is cyclonic in winter and fall and strongly anticyclonic in summer. The addition of freshwater run-off greatly enhances the eddy kinetic energy in PWS partly through near-surface baroclinic instabilities. This leads to a much more intermittent circulation in the central Sound, with the presence of intense small-scale turbulence and a disappearance of the summer wind-forced anticyclonic cell. The addition of tides reduces the turbulence intensity (relatively to the experiment with run-off only), particularly in the central Sound. The generation of turbulent motions by baroclinic processes is lowered by tidal mixing and by modification of the exchange at Hinchinbrook Entrance. Tides have an overall stabilizing effect on the central Sound circulation. Tidal rectification currents help maintain a mean cyclonic circulation throughout the year.

77 FR 26660 - Guidelines for the Transfer of Excess Computers or Other Technical Equipment Pursuant to Section...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

....usda.gov . SUPPLEMENTARY INFORMATION: A. Background A proposed rule was published in the Federal.... Computers or other technical equipment means central processing units, laptops, desktops, computer mouses...

The amblyopic eye in subjects with anisometropia show increased saccadic latency in the delayed saccade task

PubMed Central

Perdziak, Maciej; Witkowska, Dagmara; Gryncewicz, Wojciech; Przekoracka-Krawczyk, Anna; Ober, Jan

2014-01-01

The term amblyopia is used to describe reduced visual function in one eye (or both eyes, though not so often) which cannot be fully improved by refractive correction and explained by the organic cause observed during regular eye examination. Amblyopia is associated with abnormal visual experience (e.g., anisometropia) during infancy or early childhood. Several studies have shown prolongation of saccadic latency time in amblyopic eye. In our opinion, study of saccadic latency in the context of central vision deficits assessment, should be based on central retina stimulation. For this reason, we proposed saccade delayed task. It requires inhibitory processing for maintaining fixation on the central target until it disappears—what constitutes the GO signal for saccade. The experiment consisted of 100 trials for each eye and was performed under two viewing conditions: monocular amblyopic/non-dominant eye and monocular dominant eye. We examined saccadic latency in 16 subjects (mean age 30 ± 11 years) with anisometropic amblyopia (two subjects had also microtropia) and in 17 control subjects (mean age 28 ± 8 years). Participants were instructed to look at central (fixation) target and when it disappears, to make the saccade toward the periphery (10°) as fast as possible, either left or the right target. The study results have proved the significant difference in saccadic latency between the amblyopic (mean 262 ± 48 ms) and dominant (mean 237 ± 45 ms) eye, in anisometropic group. In the control group, the saccadic latency for dominant (mean 226 ± 32 ms) and non-dominant (mean 230 ± 29 ms) eye was not significantly different. By the use of LATER (Linear Approach to the Threshold with Ergodic Rate) decision model we interpret our findings as a decrease in accumulation of visual information acquired by means of central retina in subjects with anisometropic amblyopia. PMID:25352790

Altered central nervous system processing of baroreceptor input following hindlimb unloading in rats

NASA Technical Reports Server (NTRS)

Moffitt, J. A.; Schadt, J. C.; Hasser, E. M.

1999-01-01

The effect of cardiovascular deconditioning on central nervous system processing of baroreceptor afferent activity was evaluated following 14 days of hindlimb unloading (HU). Inactin-anesthetized rats were instrumented with catheters, renal sympathetic nerve electrodes, and aortic depressor nerve electrodes for measurement of mean arterial pressure, heart rate, renal sympathetic nerve activity (RSNA), and aortic depressor nerve activity (ADNA). Baroreceptor and baroreflex functions were assessed during infusion of phenylephrine and sodium nitroprusside. Central processing of baroreceptor afferent input was evaluated by linear regression relating RSNA to ADNA. The maximum baroreflex-elicited increase in RSNA was significantly reduced in HU rats (122 +/- 3.8 vs. 144 +/- 4.9% of baseline RSNA), whereas ADNA was not altered. The slope (-0.18 +/- 0.04 vs. -0.40 +/- 0.04) and y-intercept (121 +/- 3.2 vs. 146 +/- 4.3) of the linear regression relating increases in efferent RSNA to decreases in afferent ADNA during hypotension were significantly reduced in HU rats. There were no differences during increases in arterial pressure. Results demonstrate that the attenuation in baroreflex-mediated increases in RSNA following HU is due to changes in central processing of baroreceptor afferent information rather than aortic baroreceptor function.

Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial.

PubMed

Kalpatthi, Ram; Thompson, Bruce; Lu, Ming; Wang, Winfred C; Patel, Niren; Kutlar, Abdullah; Howard, Thomas; Luchtman-Jones, Lori; Miller, Scott T

2013-02-01

To investigate the concordance of blood count indices measured locally and at a central laboratory. In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated. Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally. Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials. Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Planning Management Training Programs for Organizational Development

ERIC Educational Resources Information Center

Alpander, Guvenc G.

1974-01-01

To investigate means of converting management development programs into a successful organizational development process, managers' attitudes toward centralization and decentralization of functions and decisions, the importance of performed functions, their personal effectiveness, their managerial style, and what they prefer for executive…

Attributing Social and Physical Meaning to Ambiguous Visual Displays in Individuals with Higher-Functioning Autism Spectrum Disorders

ERIC Educational Resources Information Center

Klin, Ami; Jones, Warren

2006-01-01

The weak central coherence (WCC) account of autism characterizes the learning style of individuals with this condition as favoring localized and fragmented (to the detriment of global and integrative) processing of information. This pattern of learning is thought to lead to deficits in aspects of perception (e.g., face processing), cognition, and…

Inquiry Based Learning and Meaning Generation through Modelling on Geometrical Optics in a Constructionist Environment

ERIC Educational Resources Information Center

Kotsari, Constantina; Smyrnaiou, Zacharoula

2017-01-01

The central roles that modelling plays in the processes of scientific enquiry and that models play as the outcomes of that enquiry are well established (Gilbert & Boulter, 1998). Besides, there are considerable similarities between the processes and outcomes of science and technology (Cinar, 2016). In this study, we discuss how the use of…

Meaning making in the aftermath of homicide.

PubMed

Armour, Marilyn

2003-07-01

Although sense making or finding benefit are well documented examples of meaning making processes, meaning making grounded in action has received less attention. This article adds a specific demonstration of the relevance of performed meanings to homicide survivors and other traumatized populations through a qualitative study of 38 members of 14 families. The central finding of the study points to "the intense pursuit of what matters" as a major avenue for meaning making in the aftermath of homicide, one which is expressed in action. Implications of this mode of meaning reconstruction are discussed relative to the re-establishment of a sense of coherence and self-continuity.

Rare Central Pacific El Niño Events Caused by Interdecadal Tropical Pacific Variability

NASA Astrophysics Data System (ADS)

Zhong, Wenxiu; Zheng, Xiaotong; Cai, Wenju

2017-04-01

The frequency of Central Pacific (CP) El Niño events displays strong decadal-variability but the associated dynamics is still not clear. The Inter-decadal Pacific Oscillation (IPO) and the Tropical Pacific Decadal Variability (TPDV) are two dominant modes of the Pacific low-frequency variability that can modify high-frequency behaviors. Using a 500-year control integration of Geophysical Fluid Dynamics Laboratory Earth System Model simulation, we find that the mean state, determined by the two independent modes of tropical Pacific decadal variability, strongly affects CP El Niño frequency and the associated developing processes. A positive TPDV features a shallow thermocline and cool sea surface temperature anomalies (SSTAs) across the central-to-western tropical Pacific, and a negative IPO features cool SSTAs and strong trade winds along the equatorial Pacific. The combination of a positive TPDV and a negative IPO generates a decadal mean state, in which the climatological zonal temperature gradient is reduced, equatorward and westward current anomalies are harder to be generated over the central-to-western tropical Pacific, resulting in the lack of CP El Niño.

Study on the application of the time-compressed speech in children.

PubMed

Padilha, Fernanda Yasmin Odila Maestri Miguel; Pinheiro, Maria Madalena Canina

2017-11-09

To analyze the performance of children without alteration of central auditory processing in the Time-compressed Speech Test. This is a descriptive, observational, cross-sectional study. Study participants were 22 children aged 7-11 years without central auditory processing disorders. The following instruments were used to assess whether these children presented central auditory processing disorders: Scale of Auditory Behaviors, simplified evaluation of central auditory processing, and Dichotic Test of Digits (binaural integration stage). The Time-compressed Speech Test was applied to the children without auditory changes. The participants presented better performance in the list of monosyllabic words than in the list of disyllabic words, but with no statistically significant difference. No influence on test performance was observed with respect to order of presentation of the lists and the variables gender and ear. Regarding age, difference in performance was observed only in the list of disyllabic words. The mean score of children in the Time-compressed Speech Test was lower than that of adults reported in the national literature. Difference in test performance was observed only with respect to the age variable for the list of disyllabic words. No difference was observed in the order of presentation of the lists or in the type of stimulus.

Multinucleon transfer in central collisions of 238U+238U

NASA Astrophysics Data System (ADS)

Ayik, S.; Yilmaz, B.; Yilmaz, O.; Umar, A. S.; Turan, G.

2017-08-01

Quantal diffusion mechanism of nucleon exchange is studied in the central collisions of 238U+238U in the framework of the stochastic mean-field (SMF) approach. For bombarding energies considered in this work, the dinuclear structure is maintained during the collision. Hence, it is possible to describe nucleon exchange as a diffusion process for mass and charge asymmetry. Quantal neutron and proton diffusion coefficients, including memory effects, are extracted from the SMF approach and the primary fragment distributions are calculated.

Inhabiting Different Bodies over Time: Narrative and Pedagogical Challenges

ERIC Educational Resources Information Center

Sparkes, Andrew C.; Smith, Brett

2011-01-01

Over the life course our "real" bodies change and we come to inhabit them and know them and ourselves in different ways. Of course, just how we learn to inhabit different bodies in the flesh and give meaning to them over time is a complex relational process that has consequences for our being in the world. Central to this process is the role of…

Power of theta waves in the EEG of human subjects increases during recall of haptic information.

PubMed

Grunwald, M; Weiss, T; Krause, W; Beyer, L; Rost, R; Gutberlet, I; Gertz, H J

1999-02-05

Several studies have reported a functional relationship between spectral power within the theta-band of the EEG (theta-power) and memory load while processing visual or semantic information. We investigated theta power during the processing of different complex haptic stimuli using a delayed recall design. The haptic explorations consisted of palpating the structure of twelve sunken reliefs with closed eyes. Subjects had to reproduce each relief by drawing it 10 s after the end of the exploration. The relationship between mean theta power and mean exploration time was analysed using a regression model. A linear relationship was found between the exploration time and theta power over fronto-central regions (Fp1, Fp2, F3, F7, F8, Fz, C3) directly before the recall of the relief. This result is interpreted in favour of the hypothesis that fronto-central theta power of the EEG correlates with the load of working memory independent of stimulus modality.

A magnetic resonance imaging finding in children with cerebral palsy: Symmetrical central tegmental tract hyperintensity.

PubMed

Derinkuyu, Betul Emine; Ozmen, Evrim; Akmaz-Unlu, Havva; Altinbas, Namik Kemal; Gurkas, Esra; Boyunaga, Oznur

2017-03-01

Central tegmental tract is an extrapyramidal tract between red nucleus and inferior olivary nucleus which is located in the tegmentum pontis bilaterally and symmetrically. The etiology of the presence of central tegmental tract hyperintensity on MRI is unclear. In this study our aim is to evaluate the frequency of central tegmental tract lesions in patients with cerebral palsy and control group, as well as to determine whether there is an association between central tegmental tract lesions and cerebral palsy types. Clinical and MRI data of 200 patients with cerebral palsy in study group (87 female, 113 male; mean age, 5.81years; range, 0-16years) and 258 patients in control group (114 female, 144 male; mean age, 6.28years; range, 0-16years) were independently evaluated by two reader for presence of central tegmental tract hyperintensity and other associated abnormalities. Central tegmental tract hyperintensities on T2WI were detected in 19% of the study group (38/200) and 3.5% of the control group (9/258) (p<0.0001). Among the total of 38 central tegmental tract lesions in study group, the frequency of central tegmental tract hyperintensity was 16% (24/150) in spastic cerebral palsy and 35% (14/40) in dyskinetic cerebral palsy (p=0.0131). The prevalence of central tegmental tract hyperintensity is higher in patients with cerebral palsy particularly in dyskinetic type. We suggest that there is an increased association of the tegmental lesions with dyskinetic CP. Patients with cerebral palsy and ischemic changes were more likely to have central tegmental tract lesions. According to our results we advocate that an ischemic process may have a role in the etiopathogenesis. Copyright © 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Black Lights: Chaos, Complexity, and the Promise of Information Warfare

DTIC Science & Technology

1997-01-01

control— cybernetics—and the etymology of control, a term which comes from the Latin contrarotulare, mean- ing to mark similarities and differences...in the brain and central nervous system. Chemistry domi- nated life processes for four billion years until primitive electronics became important when

Forward J / ψ production at high energy: Centrality dependence and mean transverse momentum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ducloué, B.; Lappi, T.; Mäntysaari, H.

2016-10-21

Forward rapidity J/more » $$\\psi$$ meson production in proton-nucleus collisions can be an important constraint of descriptions of the small- x nuclear wave function. In an earlier work we studied this process using a dipole cross section satisfying the Balitsky-Kovchegov equation, fit to HERA inclusive data and consistently extrapolated to the nuclear case using a standard Woods-Saxon distribution. In this paper we present further calculations of these cross sections, studying the mean transverse momentum of the meson and the dependence on collision centrality. We also extend the calculation to backward rapidities using nuclear parton distribution functions. Here, we show that the parametrization is overall rather consistent with the available experimental data. However, there is a tendency towards a too strong centrality dependence. This can be traced back to the rather small transverse area occupied by small- x gluons in the nucleon that is seen in the HERA data, compared to the total inelastic nucleon-nucleon cross section.« less

Gender effect on pre-attentive change detection in major depressive disorder patients revealed by auditory MMN.

PubMed

Qiao, Zhengxue; Yang, Aiying; Qiu, Xiaohui; Yang, Xiuxian; Zhang, Congpei; Zhu, Xiongzhao; He, Jincai; Wang, Lin; Bai, Bing; Sun, Hailian; Zhao, Lun; Yang, Yanjie

2015-10-30

Gender differences in rates of major depressive disorder (MDD) are well established, but gender differences in cognitive function have been little studied. Auditory mismatch negativity (MMN) was used to investigate gender differences in pre-attentive information processing in first episode MDD. In the deviant-standard reverse oddball paradigm, duration auditory MMN was obtained in 30 patients (15 males) and 30 age-/education-matched controls. Over frontal-central areas, mean amplitude of increment MMN (to a 150-ms deviant tone) was smaller in female than male patients; there was no sex difference in decrement MMN (to a 50-ms deviant tone). Neither increment nor decrement MMN differed between female and male patients over temporal areas. Frontal-central MMN and temporal MMN did not differ between male and female controls in any condition. Over frontal-central areas, mean amplitude of increment MMN was smaller in female patients than female controls; there was no difference in decrement MMN. Neither increment nor decrement MMN differed between female patients and female controls over temporal areas. Frontal-central MMN and temporal MMN did not differ between male patients and male controls. Mean amplitude of increment MMN in female patients did not correlate with symptoms, suggesting this sex-specific deficit is a trait- not a state-dependent phenomenon. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Keep meaning in conversational coordination

PubMed Central

Cuffari, Elena C.

2014-01-01

Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making). These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination. PMID:25520693

Improvement attributes in healthcare: implications for integrated care.

PubMed

Harnett, Patrick John

2018-04-16

Purpose Healthcare quality improvement is a key concern for policy makers, regulators, carers and service users. Despite a contemporary consensus among policy makers that integrated care represents a means to substantially improve service outcomes, progress has been slow. Difficulties achieving sustained improvement at scale imply that methods employed are not sufficient and that healthcare improvement attributes may be different when compared to prior reference domains. The purpose of this paper is to examine and synthesise key improvement attributes relevant to a complex healthcare change process, specifically integrated care. Design/methodology/approach This study is based on an integrative literature review on systemic improvement in healthcare. Findings A central theme emerging from the literature review indicates that implementing systemic change needs to address the relationship between vision, methods and participant social dynamics. Practical implications Accommodating personal and professional network dynamics is required for systemic improvement, especially among high autonomy individuals. This reinforces the need to recognise the change process as taking place in a complex adaptive system where personal/professional purpose/meaning is central to the process. Originality/value Shared personal/professional narratives are insufficiently recognised as a powerful change force, under-represented in linear and rational empirical improvement approaches.

C. S. Peirce's Dialogical Conception of Sign Processes

ERIC Educational Resources Information Center

Bergman, Mats

2005-01-01

This article examines the contention that the central concepts of C. S. Peirce's semeiotic are inherently communicational. It is argued that the Peircean approach avoids the pitfalls of objectivism and constructivism, rendering the sign-user neither a passive recipient nor an omnipotent creator of meaning. Consequently, semeiotic may serve as a…

Watching Race. Television and the Struggle for "Blackness."

ERIC Educational Resources Information Center

Gray, Herman

Critical debates about black expressive culture and black cultural productions within television are examined as a means of exploring processes by which questions about the American racial order, and blackness itself, are constructed, reproduced, and challenged. The central thread of the argument is that commercial culture operates as both a site…

Enfants autochtones et apprentissage: la corporalité comme langage en Amérique du Sud tropicale

NASA Astrophysics Data System (ADS)

da Silva, Aracy Lopes

1999-05-01

In this article on the cultural context of children's learning processes among the indigenous peoples of tropical South America, the author aims to show how in these cultures the human body offers a language and a mechanism central to the process of production, elaboraton and transmission of knowledge, skills and emotions. She works from the assumption that the construction of a child's identity is a process which takes place in the body, creating a synthesis of social, cosmological, psychological, emotional and cognitive meanings. In constructing an ethnography of the Akwe~-Xavante and Akwe~-Xerente peoples of central Brazil, the author refers to recent anthropological debates on the cosmology and outlook of the indigenous peoples of this region, as well as to the literature of the new discipline known as "anthropology of the child".

Improving Adherence to Mediterranean-Style Diet With a Community Culinary Coaching Program: Methodology Development and Process Evaluation.

PubMed

Polak, Rani; Pober, David; Morris, Avigail; Arieli, Rakefet; Moore, Margaret; Berry, Elliot; Ziv, Mati

The Community Culinary Coaching Program is a community-based participatory program aimed at improving communal settlement residents' nutrition. The residents, central kitchens, preschools, and communal dining rooms were identified as areas for intervention. Evaluation included goals accomplishment assessed by food purchases by the central kitchens, and residents' feedback through focus groups. Purchasing included more vegetables (mean (standard error) percent change), (+7% (4); P = .32), fish (+115% (11); P < .001), whole grains, and legumes (+77% (9); P < .001); and less soup powders (-40% (9); P < .05), processed beef (-55% (8); P < .001), and margarine (-100% (4); P < .001). Residents recommended continuing the program beyond the project duration. This model might be useful in organizations with communal dining facilities.

The Time Course of Verb Processing in Dutch Sentences

PubMed Central

Shapiro, Lewis P.; Wester, Femke; Swinney, David A.; Bastiaanse, Roelien

2012-01-01

The verb has traditionally been characterized as the central element in a sentence. Nevertheless, the exact role of the verb during the actual ongoing comprehension of a sentence as it unfolds in time remains largely unknown. This paper reports the results of two Cross-Modal Lexical Priming (CMLP) experiments detailing the pattern of verb priming during on-line processing of Dutch sentences. Results are contrasted with data from a third CMLP experiment on priming of nouns in similar sentences. It is demonstrated that the meaning of a matrix verb remains active throughout the entire matrix clause, while this is not the case for the meaning of a subject head noun. Activation of the meaning of the verb only dissipates upon encountering a clear signal as to the start of a new clause. PMID:19452278

Abnormal Resting-State Quantitative Electroencephalogram in Children With Central Auditory Processing Disorder: A Pilot Study

PubMed Central

Milner, Rafał; Lewandowska, Monika; Ganc, Małgorzata; Włodarczyk, Elżbieta; Grudzień, Diana; Skarżyński, Henryk

2018-01-01

In this study, we showed an abnormal resting-state quantitative electroencephalogram (QEEG) pattern in children with central auditory processing disorder (CAPD). Twenty-seven children (16 male, 11 female; mean age = 10.7 years) with CAPD and no symptoms of other developmental disorders, as well as 23 age- and sex-matched, typically developing children (TDC, 11 male, 13 female; mean age = 11.8 years) underwent examination of central auditory processes (CAPs) and QEEG evaluation consisting of two randomly presented blocks of “Eyes Open” (EO) or “Eyes Closed” (EC) recordings. Significant correlations between individual frequency band powers and CAP tests performance were found. The QEEG studies revealed that in CAPD relative to TDC there was no effect of decreased delta absolute power (1.5–4 Hz) in EO compared to the EC condition. Furthermore, children with CAPD showed increased theta power (4–8 Hz) in the frontal area, a tendency toward elevated theta power in EO block, and reduced low-frequency beta power (12–15 Hz) in the bilateral occipital and the left temporo-occipital regions for both EO and EC conditions. Decreased middle-frequency beta power (15–18 Hz) in children with CAPD was observed only in the EC block. The findings of the present study suggest that QEEG could be an adequate tool to discriminate children with CAPD from normally developing children. Correlation analysis shows relationship between the individual EEG resting frequency bands and the CAPs. Increased power of slow waves and decreased power of fast rhythms could indicate abnormal functioning (hypoarousal of the cortex and/or an immaturity) of brain areas not specialized in auditory information processing.

Relationship between slow visual processing and reading speed in people with macular degeneration

PubMed Central

Cheong, Allen MY; Legge, Gordon E; Lawrence, Mary G; Cheung, Sing-Hang; Ruff, Mary A

2007-01-01

Purpose People with macular degeneration (MD) often read slowly even with adequate magnification to compensate for acuity loss. Oculomotor deficits may affect reading in MD, but cannot fully explain the substantial reduction in reading speed. Central-field loss (CFL) is often a consequence of macular degeneration, necessitating the use of peripheral vision for reading. We hypothesized that slower temporal processing of visual patterns in peripheral vision is a factor contributing to slow reading performance in MD patients. Methods Fifteen subjects with MD, including 12 with CFL, and five age-matched control subjects were recruited. Maximum reading speed and critical print size were measured with RSVP (Rapid Serial Visual Presentation). Temporal processing speed was studied by measuring letter-recognition accuracy for strings of three randomly selected letters centered at fixation for a range of exposure times. Temporal threshold was defined as the exposure time yielding 80% recognition accuracy for the central letter. Results Temporal thresholds for the MD subjects ranged from 159 to 5881 ms, much longer than values for age-matched controls in central vision (13 ms, p<0.01). The mean temporal threshold for the 11 MD subjects who used eccentric fixation (1555.8 ± 1708.4 ms) was much longer than the mean temporal threshold (97.0 ms ± 34.2 ms, p<0.01) for the age-matched controls at 10° in the lower visual field. Individual temporal thresholds accounted for 30% of the variance in reading speed (p<0.05). Conclusion The significant association between increased temporal threshold for letter recognition and reduced reading speed is consistent with the hypothesis that slower visual processing of letter recognition is one of the factors limiting reading speed in MD subjects. PMID:17881032

ConnectX2 In niBand Management Queues: New support for Network Of oaded

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, Richard L; Poole, Stephen W; Shamis, Pavel

2010-01-01

This paper introduces the newly developed InfiniBand (IB) Management Queue capability, used by the Host Channel Adapter (HCA) to manage network task data flow dependancies, and progress the communications associated with such flows. These tasks include sends, receives, and the newly supported wait task, and are scheduled by the HCA based on a data dependency description provided by the user. This functionality is supported by the ConnectX-2 HCA, and provides the means for delegating collective communication management and progress to the HCA, also known as collective communication offload. This provides a means for overlapping collective communications managed by the HCAmore » and computation on the Central Processing Unit (CPU), thus making it possible to reduce the impact of system noise on parallel applications using collective operations. This paper further describes how this new capability can be used to implement scalable Message Passing Interface (MPI) collective operations, describing the high level details of how this new capability is used to implement the MPI Barrier collective operation, focusing on the latency sensitive performance aspects of this new capability. This paper concludes with small scale benchmark experiments comparing implementations of the barrier collective operation, using the new network offload capabilities, with established point-to-point based implementations of these same algorithms, which manage the data flow using the central processing unit. These early results demonstrate the promise this new capability provides to improve the scalability of high-performance applications using collective communications. The latency of the HCA based implementation of the barrier is similar to that of the best performing point-to-point based implementation managed by the central processing unit, starting to outperform these as the number of processes involved in the collective operation increases.« less

ConnectX-2 InfiniBand Management Queues: First Investigation of the New Support for Network Offloaded Collective Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, Richard L; Poole, Stephen W; Shamis, Pavel

2010-01-01

This paper introduces the newly developed Infini-Band (IB) Management Queue capability, used by the Host Channel Adapter (HCA) to manage network task data flow dependancies, and progress the communications associated with such flows. These tasks include sends, receives, and the newly supported wait task, and are scheduled by the HCA based on a data dependency description provided by the user. This functionality is supported by the ConnectX-2 HCA, and provides the means for delegating collective communication management and progress to the HCA, also known as collective communication offload. This provides a means for overlapping collective communications managed by the HCAmore » and computation on the Central Processing Unit (CPU), thus making it possible to reduce the impact of system noise on parallel applications using collective operations. This paper further describes how this new capability can be used to implement scalable Message Passing Interface (MPI) collective operations, describing the high level details of how this new capability is used to implement the MPI Barrier collective operation, focusing on the latency sensitive performance aspects of this new capability. This paper concludes with small scale benchmark experiments comparing implementations of the barrier collective operation, using the new network offload capabilities, with established point-to-point based implementations of these same algorithms, which manage the data flow using the central processing unit. These early results demonstrate the promise this new capability provides to improve the scalability of high performance applications using collective communications. The latency of the HCA based implementation of the barrier is similar to that of the best performing point-to-point based implementation managed by the central processing unit, starting to outperform these as the number of processes involved in the collective operation increases.« less

The Invisible Wall Project: Reasoning and Problem Solving Processes of Primary and Lower Secondary Students

ERIC Educational Resources Information Center

Stein, Martin; Burchartz, Birgit

2006-01-01

The Invisible Wall Project analyzes problem-solving processes of children in Grades 3 and 4 and Grades 8 and 9. The central idea of the research is to use sets of tasks that are all unsolvable, which means they have a goal that cannot be reached. The unsolvability, however, is of a kind that can be understood even by younger children. In our case,…

Differentiating between appraisal process and product in cognitive theories of posttraumatic stress

PubMed Central

Nanney, John T.; Constans, Joseph I.; Kimbrell, Timothy A.; Kramer, Teresa L.; Pyne, Jeffrey M.

2014-01-01

Biased appraisal is central to cognitive theories of posttraumatic stress, but little research has examined the potentially distinct meanings of the term. The on-going process of appraising social information and the beliefs that emerge as products of that process can be distinguished conceptually. The present study sought to examine if these two meanings are empirically distinct as well, and if so, to begin exploring potential relations between these appraisal constructs and posttraumatic stress symptoms. Soldiers (N = 424) preparing for deployment to Iraq or Afghanistan were administered measures of each construct. Results of confirmatory factor analysis suggest that the appraisal process and the products of that process (i.e., beliefs) are indeed distinct. Structural equation models are consistent with cognitive bias and social information processing literatures which posit that a biased appraisal process may contribute to the development of dysfunctional beliefs and posttraumatic stress symptoms following trauma. The potential utility of distinctly conceptualizing and measuring the appraisal process in both clinical and research settings is discussed. PMID:26147520

Differentiating between appraisal process and product in cognitive theories of posttraumatic stress.

PubMed

Nanney, John T; Constans, Joseph I; Kimbrell, Timothy A; Kramer, Teresa L; Pyne, Jeffrey M

2015-07-01

Biased appraisal is central to cognitive theories of posttraumatic stress, but little research has examined the potentially distinct meanings of the term. The ongoing process of appraising social information and the beliefs that emerge as products of that process can be distinguished conceptually. This study sought to examine whether these 2 meanings are empirically distinct as well, and if so, to begin exploring potential relations between these appraisal constructs and posttraumatic stress symptoms. Soldiers (N = 424) preparing for deployment to Iraq or Afghanistan were administered measures of each construct. Results of confirmatory factor analysis suggest that the appraisal process and the products of that process (i.e., beliefs) are indeed distinct. Structural equation models are consistent with cognitive bias and social information processing literatures, which posit that a biased appraisal process may contribute to the development of dysfunctional beliefs and posttraumatic stress symptoms following trauma. The potential utility of distinctly conceptualizing and measuring the appraisal process in both clinical and research settings is discussed. (c) 2015 APA, all rights reserved).

Two perspectives on the needs of individuals bereaved by suicide.

PubMed

Gall, Terry Lynn; Henneberry, Jesse; Eyre, Melissa

2014-01-01

To qualitatively explore the needs of suicidally bereaved individuals, researchers interviewed 11 suicide bereaved individuals and 4 mental health workers. Common themes of bereaved persons included the suicide grief experience, coping, interpersonal domain, struggle with meaning, self-reflection, and moving forward. Mental health workers emphasized the nature of the helping relationship, the need to emotionally process the grief, the centrality of meaning making, importance of support groups, and the role of individual counseling. These 2 perspectives informed "best practices" for postvention (e.g., understanding the need for meaning-making while recognizing when to move on).

(The feeling of) meaning-as-information.

PubMed

Heintzelman, Samantha J; King, Laura A

2014-05-01

The desire for meaning is recognized as a central human motive. Yet, knowing that people want meaning does not explain its function. What adaptive problem does this experience solve? Drawing on the feelings-as-information hypothesis, we propose that the feeling of meaning provides information about the presence of reliable patterns and coherence in the environment, information that is not provided by affect. We review research demonstrating that manipulations of stimulus coherence influence subjective reports of meaning in life but not affect. We demonstrate that manipulations that foster an associative mindset enhance meaning. The meaning-as-information perspective embeds meaning in a network of foundational functions including associative learning, perception, cognition, and neural processing. This approach challenges assumptions about meaning, including its motivational appeal, the roles of expectancies and novelty in this experience, and the notion that meaning is inherently constructed. Implications for constructed meaning and existential meanings are discussed.

Opening to Possibility: Reflectivity and Reflexivity in Our Teaching

ERIC Educational Resources Information Center

Wilhelm, Jeff, Ed.

2013-01-01

This commentary explores how teachers can create a culture of tolerance by promoting reflectivity and reflexivity, and considers classroom processes and activities for doing so. "Reflectivity" is considered to be the use of personal values, experiences, and habits to make meaning and is a central tenet of inquiry approaches: to build…

The Limitations of Access Alone: Moving Towards Open Processes in Education Technology

ERIC Educational Resources Information Center

Knox, Jeremy

2013-01-01

"Openness" has emerged as one of the foremost themes in education, within which an open education movement has enthusiastically embraced digital technologies as the central means of participation and inclusion. Open Educational Resources (OERs) and Massive Open Online Courses (MOOCs) have surfaced at the forefront of this development,…

Examining the Process of Developing a Research-Based Mathematics Curriculum and Its Policy Implications

ERIC Educational Resources Information Center

Superfine, Alison Castro; Kelso, Catherine Randall; Beal, Susan

2010-01-01

The implementation of "research-based" mathematics curricula is increasingly becoming a central element of mathematics education reform policies. Given the recent focus on grounding mathematics curriculum policies in research, it is important to understand precisely what it means for a curriculum to be research-based. Using the Curriculum Research…

Communication with Children: Toward a Healthy Construction of Communicative Roles.

ERIC Educational Resources Information Center

Johnson, Fern L.

The family system--a primary locus in the formation of meaning for children--should encourage the healthy construction of communicative roles. What children learn about interaction is contingent on two processes, both central to the symbolic interaction perspective: role-taking and role-making. Role-taking is the ability to transcend an egocentric…

Connecting Creativity and Critical Thinking to the Campaign Planning Process

ERIC Educational Resources Information Center

Matthews, Marsha Little

2011-01-01

Creativity is the central source of meaning for humans and is inseparable from critical thinking. Creativity and critical thinking are required in the fields of communication, public relations, and advertising. Most college students know the "rules" of the "game" of schooling, but for the majority, creativity has been all but extinguished by the…

12 CFR 725.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.2 Definitions. As used in this part: (a) Agent means an Agent... loan means an advance of funds by an Agent to a member natural person credit union to meet liquidity... or Central Liquidity Facility means the National Credit Union Administration Central Liquidity...

A psychodynamic model of behavior after acute central nervous system damage.

PubMed

Groswasser, Z; Stern, M J

1998-02-01

This article describes a conceptual psychodynamic model for understanding the neurobehavioral manifestations of acute central nervous system damage (ACNSD) displayed by patients during the rehabilitation process. According to the proposed model, patientsO behavioral responses are viewed as their only means of emotional expression and therefore may not be considered entirely abnormal when viewed from the perspective of patientsO interpersonal contexts. An improved understanding of the dynamic processes through which recovering patients with ACNSD journey may lead to better interaction between the patient and the therapeutic environment, the interdisciplinary team, and family members. Combining this proposed psychodynamic model with an emerging understanding of the neurobehavioral foundations of aggression and depression may also lead to a more rational approach to intervention with various psychopharmacologic agents. During the rehabilitation process, understanding patients' cognitive deficits, motivational drives, and emotional needs and proper implementation of medical and environmental treatment can ultimately lead to a better psychosocial outcome.

An order statistics approach to the halo model for galaxies

NASA Astrophysics Data System (ADS)

Paul, Niladri; Paranjape, Aseem; Sheth, Ravi K.

2017-04-01

We use the halo model to explore the implications of assuming that galaxy luminosities in groups are randomly drawn from an underlying luminosity function. We show that even the simplest of such order statistics models - one in which this luminosity function p(L) is universal - naturally produces a number of features associated with previous analyses based on the 'central plus Poisson satellites' hypothesis. These include the monotonic relation of mean central luminosity with halo mass, the lognormal distribution around this mean and the tight relation between the central and satellite mass scales. In stark contrast to observations of galaxy clustering; however, this model predicts no luminosity dependence of large-scale clustering. We then show that an extended version of this model, based on the order statistics of a halo mass dependent luminosity function p(L|m), is in much better agreement with the clustering data as well as satellite luminosities, but systematically underpredicts central luminosities. This brings into focus the idea that central galaxies constitute a distinct population that is affected by different physical processes than are the satellites. We model this physical difference as a statistical brightening of the central luminosities, over and above the order statistics prediction. The magnitude gap between the brightest and second brightest group galaxy is predicted as a by-product, and is also in good agreement with observations. We propose that this order statistics framework provides a useful language in which to compare the halo model for galaxies with more physically motivated galaxy formation models.

Central intake to improve access to physiotherapy for children with complex needs: a mixed methods case report.

PubMed

Wittmeier, Kristy D M; Restall, Gayle; Mulder, Kathy; Dufault, Brenden; Paterson, Marie; Thiessen, Matthew; Lix, Lisa M

2016-08-31

Children with complex needs can face barriers to system access and navigation related to their need for multiple services and healthcare providers. Central intake for pediatric rehabilitation was developed and implemented in 2008 in Winnipeg Manitoba Canada as a means to enhance service coordination and access for children and their families. This study evaluates the process and impact of implementing a central intake system, using pediatric physiotherapy as a case example. A mixed methods instrumental case study design was used. Interviews were completed with 9 individuals. Data was transcribed and analyzed for themes. Quantitative data (wait times, referral volume and caregiver satisfaction) was collected for children referred to physiotherapy with complex needs (n = 1399), and a comparison group of children referred for orthopedic concerns (n = 3901). Wait times were analyzed using the Kruskal-Wallis test, caregiver satisfaction was analyzed using Fisher exact test and change point modeling was applied to examine referral volume over the study period. Interview participants described central intake implementation as creating more streamlined processes. Factors that facilitated successful implementation included 1) agreement among stakeholders, 2) hiring of a central intake coordinator, 3) a financial commitment from the government and 4) leadership at the individual and organization level. Mean (sd) wait times improved for children with complex needs (12.3(13.1) to 8.0(6.9) days from referral to contact with family, p < 0.0001; 29.8(17.9) to 24.3(17.0) days from referral to appointment, p < 0.0001) while referral volumes remained consistent. A small but significant increase in wait times was observed for the comparison group (9.6(8.6) to 10.1(6.6) days from referral to contact with family, p < 0.001; 20.4(14.3) to 22.1(13.1) days from referral to appointment, p < 0.0001), accompanied by an increasing referral volume for this group. Caregiver satisfaction remained high throughout the process (p = 0.48). Central intake implementation achieved the intended outcomes of streamlining processes and improving transparency and access to pediatric physiotherapy (i.e., decreasing wait times) for families of children with complex needs. Future research is needed to build on this single discipline case study approach to examine changes in wait times, therapy coordination and stakeholder satisfaction within the context of continuing improvements for pediatric therapy services within the province.

Occupation emerges in the process of therapy.

PubMed

Price, Pollie; Miner, Stephanie

2007-01-01

The current literature offers no cohesive definition of occupation-based practice. Current definitions emphasize intervention forms and contexts, which do not reflect the complexity of practice. This article demonstrates that the therapeutic relationship and the meanings that are created in the therapy process are central aspects of occupation-based practice. Occupation, as an idea that emerges in the therapeutic process, has aspects of both doing and becoming. The authors conducted observation sessions and interviews with an occupational therapist, Nancy, who used multiple therapeutic strategies with one child, Hannah, as they worked toward Hannah's goals of going to preschool and becoming a friend. Strategies include changing therapeutic conditions, using cognitive strategies, bridging the person-task-social context, pushing participation, and engaging in narrative micronegotiations. Occupation emerged in the therapeutic processes as the occupational therapist and client co-created meaning about the client moving toward or away from who she wanted to become.

Modern and past periglacial features in Central Asia and their implication for paleoclimate reconstructions

NASA Astrophysics Data System (ADS)

Lehmkuhl, Frank

2017-04-01

In the cold and continental areas of Central and High Asia periglacial landform assembles, sediment structures and processes are mainly influenced and determinated by the existence of soil humidity during the freeze-thaw cycles. This results in cryogenic processes and periglacial landforms such as earth hummocks, patterned ground or solifluction. The distribution of rock glaciers as clear indicators of permafrost is also determined by rock fall or moraine debris composed of large boulders (e.g. granite). Periglacial features and landforms have been used to reconstruct past climatic conditions, e.g. relict involutions and ice-wedge casts provide evidence for the distribution of former permafrost, e.g. for the Last Glacial Maximum. Past temperatures, e.g. mean annual air temperatures, can be estimated from these periglacial features. Examples from late Holocene solifluction activity in the Altai, Khangai, and north-eastern Tibetan Plateau show different intensity of solifluction processes during the Late Holocene and Little Ice Age by decrease of temperature and more soil humidity. The distribution of past permafrost in some regions is still a matter of debate due to different interpretations of sediment structures: Sometimes features described as ice-wedge casts may be caused by roots or desiccation cracks due to drying of clay rich sediments. Seismically deformed unconsolidated deposits (seismites) can also be misinterpreted as periglacial involutions. The lack of certain landform assemblages and sediment structures does not necessarily mean that the area had no permafrost as moisture conditions also to a large degree govern periglacial landform generation and not only temperature. They can be ordered in Central Asia as follows (from highest moisture availability to lowest): solifluction - rock glacier - permafrost involutions - ice-wedge casts - sand wedge casts. Reference: LEHMKUHL, F. (2016): Modern and past periglacial features in Central Asia and their implication for paleoclimate reconstructions. - Progress in Physical Geography 40: 369-391. DOI: 10.1177/0309133315615778

Coastal ocean transport patterns in the central Southern California Bight

USGS Publications Warehouse

Noble, M.A.; Rosenberger, K.J.; Hamilton, P.; Xu, J. P.

2009-01-01

In the past decade, several large programs that monitor currents and transport patterns for periods from a few months to a few years were conducted by a consortium of university, federal, state, and municipal agencies in the central Southern California Bight, a heavily urbanized section of the coastal ocean off the west coast of the United States encompassing Santa Monica Bay, San Pedro Bay, and the Palos Verdes shelf. These programs were designed in part to determine how alongshelf and cross-shelf currents move sediments, pollutants, and suspended material through the region. Analysis of the data sets showed that the current patterns in this portion of the Bight have distinct changes in frequency and amplitude with location, in part because the topography of the shelf and upper slope varies rapidly over small spatial scales. However, because the mean, subtidal, and tidal-current patterns in any particular location were reasonably stable with time, one could determine a regional pattern for these current fields in the central Southern California Bight even though measurements at the various locations were obtained at different times. In particular, because the mean near-surface flows over the San Pedro and Palos Verdes shelves are divergent, near-surface waters from the upper slope tend to carry suspended material onto the shelf in the northwestern portion of San Pedro Bay. Water and suspended material are also carried off the shelf by the mean and subtidal flow fields in places where the orientation of the shelf break changes abruptly. The barotropic tidal currents in the central Southern California Bight flow primarily alongshore, but they have pronounced amplitude variations over relatively small changes in alongshelf location that are not totally predicted by numerical tidal models. Nonlinear internal tides and internal bores at tidal frequencies are oriented more across the shelf. They do not have a uniform transport direction, since they move fine sediment from the shelf to the slope in Santa Monica Bay, but carry suspended material from the mid-shelf to the beach in San Pedro Bay. It is clear that there are a large variety of processes that transport sediments and contaminants along and across the shelf in the central Southern California Bight. However, because these processes have a variety of frequencies and relatively small spatial scales, the dominant transport processes tend to be localized and have dissimilar characteristics even in adjacent regions of this small part of the coastal ocean. ?? 2009 The Geological Society of America.

pT spectra in pp and AA collisions at RHIC and LHC energies using the Tsallis-Weibull approach

NASA Astrophysics Data System (ADS)

Dash, Sadhana; Mahapatra, D. P.

2018-04-01

The Tsallis q -statistics have been incorporated in the Weibull model of particle production, in the form of q-Weibull distribution, to describe the transverse momentum (pT) distribution of charged hadrons at mid-rapidity, measured at RHIC and LHC energies. The q-Weibull distribution is found to describe the observed pT distributions over all ranges of measured pT. Below 2.2 GeV/c, while going from peripheral to central collisions, the parameter q is found to decrease systematically towards unity, indicating an evolution from a non-equilibrated system in peripheral collisions, towards a more thermalized system in central collisions. However, the trend is reversed in the all inclusive pT regime. This can be attributed to an increase in relative contribution of hard pQCD processes in central collisions. The λ-parameter is found to be associated with the mean pT or the collective expansion velocity of the produced hadrons, which shows an expected increase with centrality of collisions. The k parameter is observed to increase with the onset of hard QCD scatterings, initial fluctuations, and other processes leading to non-equilibrium conditions.

Radio Frequency Propagation and Performance Assessment Suite (RFPPAS)

DTIC Science & Technology

2016-11-15

Intelligence, Surveillance, and Reconnaissance Clutter-to-Noise Ratio Central Processing Unit Evaporation Duct Climatology Engineer’s Refractive Effects...and maximum trapped wavelength (right) PCS display ...23 12. AREPS surface layer (evaporation duct) climatology regions...evaporation duct profiles computed from surface layer climatological statistics. The impetus for building such a database is to provide a means for instant

Making and Mistaking Reality: What is Emotional Education?

ERIC Educational Resources Information Center

Crawford, Elspeth

2005-01-01

A central thesis of this paper is that the mind and its thought evolve out of the experience of the whole person in their unique surroundings. It attempts to articulate the meaning and value of Emotional Education, especially in its relation to thought processes. It shows the value of learning from the particular, and from awareness of feeling…

Using Barbie Stories to Develop an Understanding of Polysemy and Encoding/Decoding

ERIC Educational Resources Information Center

Zaslow, Emilie

2012-01-01

Since the 1970s, communication studies scholars who teach media analysis have incorporated key concepts of critical/cultural studies into their syllabi. Of central importance has been the theory that audiences are agentic and take an active role in the process of making meaning from the media with which they engage. Fundamental to this theoretical…

Dangers Facing the Earth Charter

ERIC Educational Resources Information Center

Ruiz, Javier Reyes

2010-01-01

The article explores social and educational processes that could undermine the Earth Charter's promise. It points out that the meaning of the Charter would be affected if it is used in a doctrinaire manner, if individuals or groups assume the role of its legitimate and expert emissaries, if it takes on a messianic tone in its central ideas, if it…

Pivot Points: Direct Measures of the Content and Process of Community-Based Learning

ERIC Educational Resources Information Center

Wickersham, Carol; Westerberg, Charles; Jones, Karen; Cress, Margaret

2016-01-01

This research is an initial investigation into the ways community-based learning increase the cognitive skills central to the exercise of the sociological imagination. In addition to identifying a means to reveal that learning had occurred, we looked for evidence that the students were mastering sociological content, especially the concepts and…

The Meanings Attributed to Writing Skills in English by Turkish Children: A Concept Map Study

ERIC Educational Resources Information Center

Erginer, Ergin; Yar, Veda

2013-01-01

One of the four basic language skills of children, writing, is central to expressing themselves and to developing high level thinking capabilities. Competence in writing is a rather complex learning structure in which cognitive and, especially, psycho-motor learning processes are intensively employed and it further needs to be fed by perceptive…

Pedagogical Simulation of Sampling Distributions and the Central Limit Theorem

ERIC Educational Resources Information Center

Hagtvedt, Reidar; Jones, Gregory Todd; Jones, Kari

2007-01-01

Students often find the fact that a sample statistic is a random variable very hard to grasp. Even more mysterious is why a sample mean should become ever more Normal as the sample size increases. This simulation tool is meant to illustrate the process, thereby giving students some intuitive grasp of the relationship between a parent population…

Communists, Humboldtians, Neoliberals and Dissidents: Or the Path to a Post-Communist Homo Oeconomicus

ERIC Educational Resources Information Center

Kascak, Ondrej

2017-01-01

The neoliberalisation of higher education in post-communist central and eastern Europe, the new EU member states, is not seen as being distinct. Implementation of the Bologna Process and Lisbon Strategy means it has become part of the competitive global sphere of higher education. The transformation of post-communist higher education has attracted…

Co-Creativity and Interactive Repair: Commentary on Berta Bornstein's "The Analysis of a Phobic Child".

PubMed

Harrison, Alexandra

2014-01-01

My comments focus on a consideration of three issues central to child psychoanalysis stimulated by rereading the classic paper by Berta Bornstein, "The Analysis of a Phobic Child: Some Problems of Theory and Technique in Child Analysis": (1) the importance of "co-creativity" and its use in analysis to repair disruptions in the mother-child relationship; (2) working analytically with the "inner world of the child "; and (3) the fundamental importance of multiple simultaneous meaning-making processes. I begin with a discussion of current thinking about the importance of interactive processes in developmental and therapeutic change and then lead to the concepts of "co-creativity" and interactive repair, elements that are missing in the "Frankie" paper. The co-creative process that I outline includes multiple contributions that Frankie and his caregivers brought to their relationships--his mother, his father, his nurse, and even his analyst. I then address the question of how child analysts can maintain a central focus on the inner world of the child while still taking into account the complex nature of co-creativity in the change process. Finally, I discuss insights into the multiple simultaneous meaning-making processes in the analytic relationship to effect therapeutic change, including what I call the "sandwich model," an attempt to organize this complexity so that is more accessible to the practicing clinician. In terms of the specific case of Frankie, my reading of the case suggests that failure to repair disruptions in the mother-child relationship from infancy through the time of the analytic treatment was central to Frankie's problems. My hypothesis is that, rather than the content of his analyst's interpretations, what was helpful to Frankie in the analysis was the series of attempts at interactive repair in the analytic process. Unfortunately, the case report does not offer data to test this hypothesis. Indeed, one concluding observation from my reading of this classic case is how useful it would be for the contemporary analyst to pay attention to the multifaceted co-creative process in order to explain and foster the therapeutic change that can occur in analysis.

Benefits of a comprehensive quality program for cryopreserved PBMC covering 28 clinical trials sites utilizing an integrated, analytical web-based portal

PubMed Central

Ducar, Constance; Smith, Donna; Pinzon, Cris; Stirewalt, Michael; Cooper, Cristine; McElrath, M. Juliana; Hural, John

2014-01-01

The HIV Vaccine Trials Network (HVTN) is a global network of 28 clinical trial sites dedicated to identifying an effective HIV vaccine. Cryopreservation of high-quality peripheral blood mononuclear cells (PBMC) is critical for the assessment of vaccine-induced cellular immune functions. The HVTN PBMC Quality Management Program is designed to ensure viable PBMC are processed, stored and shipped for clinical trial assays from all HVTN clinical trial sites. The program has evolved by developing and incorporating best practices for laboratory and specimen quality and implementing automated, web-based tools. These tools allow the site-affiliated processing laboratories and the central Laboratory Operations Unit to rapidly collect, analyze and report PBMC quality data. The HVTN PBMC Quality Management Program includes five key components: 1) Laboratory Assessment, 2) PBMC Training and Certification, 3) Internal Quality Control, 4) External Quality Control (EQC), and 5) Assay Specimen Quality Control. Fresh PBMC processing data is uploaded from each clinical site processing laboratory to a central HVTN Statistical and Data Management Center database for access and analysis on a web portal. Samples are thawed at a central laboratory for assay or specimen quality control and sample quality data is uploaded directly to the database by the central laboratory. Four year cumulative data covering 23,477 blood draws reveals an average fresh PBMC yield of 1.45×106 ±0.48 cells per milliliter of useable whole blood. 95% of samples were within the acceptable range for fresh cell yield of 0.8–3.2×106 cells/ml of usable blood. Prior to full implementation of the HVTN PBMC Quality Management Program, the 2007 EQC evaluations from 10 international sites showed a mean day 2 thawed viability of 83.1% and recovery of 67.5%. Since then, four year cumulative data covering 3338 specimens used in immunologic assays shows that 99.88% had acceptable viabilities (>66%) for use in cellular assays (mean, 91.46% ±4.5%), and 96.2% had acceptable recoveries (50%–130%) with a mean of recovery of 85.8% ±19.12% of the originally cryopreserved cells. EQC testing revealed that since August 2009, failed recoveries dropped from 4.1% to 1.6% and failed viabilities dropped from 1.0% to 0.3%. The HVTN PBMC quality program provides for laboratory assessment, training and tools for identifying problems, implementing corrective action and monitoring for improvements. These data support the benefits of implementing a comprehensive, web-based PBMC quality program for large clinical trials networks. PMID:24709391

Recharge estimation in semi-arid karst catchments: Central West Bank, Palestine

NASA Astrophysics Data System (ADS)

Jebreen, Hassan; Wohnlich, Stefan; Wisotzky, Frank; Banning, Andre; Niedermayr, Andrea; Ghanem, Marwan

2018-03-01

Knowledge of groundwater recharge constitutes a valuable tool for sustainable management in karst systems. In this respect, a quantitative evaluation of groundwater recharge can be considered a pre-requisite for the optimal operation of groundwater resources systems, particular for semi-arid areas. This paper demonstrates the processes affecting recharge in Palestine aquifers. The Central Western Catchment is one of the main water supply sources in the West Bank. Quantification of potential recharge rates are estimated using chloride mass balance (CMB) and empirical recharge equations over the catchment. The results showing the spatialized recharge rate, which ranges from 111-216 mm/year, representing 19-37% of the long-term mean annual rainfall. Using Water Balance models and climatological data (e. g. solar radiation, monthly temperature, average monthly relative humidity and precipitation), actual evapotranspiration (AET) is estimated. The mean annual actual evapotranspiration was about 66-70% of precipitation.

Understanding Arctic Surface Temperature Differences in Reanalyses

NASA Technical Reports Server (NTRS)

Cullather, Richard; Zhao, Bin; Shuman, Christopher; Nowicki, Sophie

2017-01-01

Reanalyses in the Arctic are widely used for model evaluation and for understanding contemporary climate change. Nevertheless, differences among reanalyses in fundamental meteorological variables including surface air temperature are large. A review of surface temperature differences is presented with a particular focus on differences in contemporary reanalyses. An important consideration is the significant differences in Arctic surfaces, including the central Arctic Ocean, the Greenland Ice Sheet, and non-glaciated land. While there is significant correlation among reanalyses in annual time series, there is substantial disagreement in mean values. For the period 1980-2013, the trend in annual temperature ranges from 0.3 to 0.7K per decade. Over the central Arctic Ocean, differences in mean values and trends are larger. Most of the uncertainty is associated with winter months. This is likely associated with the constraint imposed by melting processes (i.e. 0 deg. Celsius), rather than seasonal changes to the observing system.

From IHE Audit Trails to XES Event Logs Facilitating Process Mining.

PubMed

Paster, Ferdinand; Helm, Emmanuel

2015-01-01

Recently Business Intelligence approaches like process mining are applied to the healthcare domain. The goal of process mining is to gain process knowledge, compliance and room for improvement by investigating recorded event data. Previous approaches focused on process discovery by event data from various specific systems. IHE, as a globally recognized basis for healthcare information systems, defines in its ATNA profile how real-world events must be recorded in centralized event logs. The following approach presents how audit trails collected by the means of ATNA can be transformed to enable process mining. Using the standardized audit trails provides the ability to apply these methods to all IHE based information systems.

When does word frequency influence written production?

PubMed

Baus, Cristina; Strijkers, Kristof; Costa, Albert

2013-01-01

The aim of the present study was to explore the central (e.g., lexical processing) and peripheral processes (motor preparation and execution) underlying word production during typewriting. To do so, we tested non-professional typers in a picture typing task while continuously recording EEG. Participants were instructed to write (by means of a standard keyboard) the corresponding name for a given picture. The lexical frequency of the words was manipulated: half of the picture names were of high-frequency while the remaining were of low-frequency. Different measures were obtained: (1) first keystroke latency and (2) keystroke latency of the subsequent letters and duration of the word. Moreover, ERPs locked to the onset of the picture presentation were analyzed to explore the temporal course of word frequency in typewriting. The results showed an effect of word frequency for the first keystroke latency but not for the duration of the word or the speed to which letter were typed (interstroke intervals). The electrophysiological results showed the expected ERP frequency effect at posterior sites: amplitudes for low-frequency words were more positive than those for high-frequency words. However, relative to previous evidence in the spoken modality, the frequency effect appeared in a later time-window. These results demonstrate two marked differences in the processing dynamics underpinning typing compared to speaking: First, central processing dynamics between speaking and typing differ already in the manner that words are accessed; second, central processing differences in typing, unlike speaking, do not cascade to peripheral processes involved in response execution.

When does word frequency influence written production?

PubMed Central

Baus, Cristina; Strijkers, Kristof; Costa, Albert

2013-01-01

The aim of the present study was to explore the central (e.g., lexical processing) and peripheral processes (motor preparation and execution) underlying word production during typewriting. To do so, we tested non-professional typers in a picture typing task while continuously recording EEG. Participants were instructed to write (by means of a standard keyboard) the corresponding name for a given picture. The lexical frequency of the words was manipulated: half of the picture names were of high-frequency while the remaining were of low-frequency. Different measures were obtained: (1) first keystroke latency and (2) keystroke latency of the subsequent letters and duration of the word. Moreover, ERPs locked to the onset of the picture presentation were analyzed to explore the temporal course of word frequency in typewriting. The results showed an effect of word frequency for the first keystroke latency but not for the duration of the word or the speed to which letter were typed (interstroke intervals). The electrophysiological results showed the expected ERP frequency effect at posterior sites: amplitudes for low-frequency words were more positive than those for high-frequency words. However, relative to previous evidence in the spoken modality, the frequency effect appeared in a later time-window. These results demonstrate two marked differences in the processing dynamics underpinning typing compared to speaking: First, central processing dynamics between speaking and typing differ already in the manner that words are accessed; second, central processing differences in typing, unlike speaking, do not cascade to peripheral processes involved in response execution. PMID:24399980

Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.

PubMed

Yano, Kanako; Yanagisawa, Takahiro; Mukae, Kyosuke; Niwa, Yasuo; Inoue, Yuko; Moriyasu, Yuji

2015-01-01

Tobacco BY-2 cells undergo autophagy in sucrose-free culture medium, which is the process mostly responsible for intracellular protein degradation under these conditions. Autophagy was inhibited by the vacuolar H(+)-ATPase inhibitors concanamycin A and bafilomycin A1, which caused the accumulation of autophagic bodies in the central vacuoles. Such accumulation did not occur in the presence of the autophagy inhibitor 3-methyladenine, and concanamycin in turn inhibited the accumulation of autolysosomes in the presence of the cysteine protease inhibitor E-64c. Electron microscopy revealed not only that the autophagic bodies were accumulated in the central vacuole, but also that autophagosome-like structures were more frequently observed in the cytoplasm in treatments with concanamycin, suggesting that concanamycin affects the morphology of autophagosomes in addition to raising the pH of the central vacuole. Using BY-2 cells that constitutively express a fusion protein of autophagosome marker protein Atg8 and green fluorescent protein (GFP), we observed the appearance of autophagosomes by fluorescence microscopy, which is a reliable morphological marker of autophagy, and the processing of the fusion protein to GFP, which is a biochemical marker of autophagy. Together, these results suggest the involvement of vacuole type H(+)-ATPase in the maturation step of autophagosomes to autolysosomes in the autophagic process of BY-2 cells. The accumulation of autophagic bodies in the central vacuole by concanamycin is a marker of the occurrence of autophagy; however, it does not necessarily mean that the central vacuole is the site of cytoplasm degradation.

Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats.

PubMed

Grauer, E; Levy, A

2007-12-05

Severe poisoning by inhibitors of cholinesterase (ChE) enzymes is often associated with prolonged central or peripheral neuronal damage. Oxotremorine is a cholinergic agonist known to induce acute hypothermia. Central and peripheral cholinergic signaling is involved in the induction of hypothermia as well as in its recovery. These processes were used in the present study to reveal prolonged neuronal abnormalities in poisoned rats, using oxotremorine with and without concomitant administration of the peripheral muscarinic antagonist methyl scopolamine. In non-poisoned naïve rats, the hypothermic effect of oxotremorine appeared faster while its recovery was delayed following co-administration of methyl scopolamine, suggesting predominantly peripheral processes in counteracting the hypothermia. One month after exposure to approximately 1LD(50) of the carbamates aldicarb and oxamyl, the hypothermic effect of oxotremorine was similar to that found in saline-treated control group. However, the effect of methyl scopolamine on the recovery process was significantly diminished, indicating that the impaired cholinergic mechanisms were predominantly peripheral. In contrast, 1 month following organophosphate (OP) poisoning by the nerve agents sarin and VX, oxotremorine-induced hypothermia was reduced, indicating mainly impaired central cholinergic mechanisms. The development of severe convulsions during nerve agent poisoning may explain the central neuronal damage in OP-poisoned rats, displayed as reduced hypothermia. As convulsions were not part of the poisoning symptoms with the carbamates tested, their long-term damage was displayed at the recovery stage. This method might be used as a relatively simple means for detecting differential long-term central and peripheral cholinergic injuries, long after toxicity signs have receded.

Positive affect, intuition, and feelings of meaning.

PubMed

Hicks, Joshua A; Cicero, David C; Trent, Jason; Burton, Chad M; King, Laura A

2010-06-01

Subjective rationality, or the feeling of meaning, was identified by William James (1893) as a central aspect of the non-sensory fringe of consciousness. Three studies examined the interaction of positive affect (PA) and individual differences in intuitive information processing in predicting feelings of meaning for various stimuli and life events. In Study 1 (N = 352), PA and intuition interacted to predict understanding for ambiguous quotes and abstract artwork. In Study 2 (N = 211), similar interactions were found for feelings of meaning for fans after their football team lost a conference championship game and for individuals not directly affected by Hurricane Katrina in events surrounding the hurricane. In Study 3 (N = 41), induced PA interacted with individual differences in intuition in predicting accuracy for coherence judgments for loosely related linguistic triads. Intuitive individuals in the positive mood condition recognized coherent triads more accurately than did other participants. Results are discussed in terms of the role of individual differences in intuitive information processing in the relationship of PA to cognition. (c) 2010 APA, all rights reserved).

Child, parent, and parent-child emotion narratives: implications for developmental psychopathology.

PubMed

Oppenheim, David

2006-01-01

Studies using narratives with children and parents offer ways to study affective meaning-making processes that are central in many theories of developmental psychopathology. This paper reviews theory regarding affective meaning making, and argues that narratives are particularly suited to examine such processes. The review of narrative studies and methods is organized into three sections according to the focus on child, parent, and parent-child narratives. Within each focus three levels of analysis are considered: (a) narrative organization and coherence, (b) narrative content, and (c) the behavior/interactions of the narrator(s). The implications of this research for developmental psychopathology and clinical work are discussed with an emphasis on parent-child jointly constructed narratives as the meeting point of individual child and parent narratives.

Meanings of care in health promotion.

PubMed

Falcón, Gladys Carmela Santos; Erdmann, Alacoque Lorenzini; Backes, Dirce Stein

2008-01-01

The objective of the study is to understand the meaning built by students and professors on health promotion in the teaching and learning process of health care in Nursing. It is a qualitative study using ground theory as a methodological reference. Data was collected through interviews, with three samples groups, 13 students and four professors, by classroom observation, and through meetings with nursing professors. The central subject resulting from this analysis was: constructing teaching and learning in order, disorder and self organization for a new way of caring promoting health. The teaching/learning process directed at health promotion develops in a stage of crisis, going from a state of order to a state of disorder that is uncertain and contradictory regarding what society understands about health.

Synesthetic colors for Japanese late acquired graphemes.

PubMed

Asano, Michiko; Yokosawa, Kazuhiko

2012-06-01

Determinants of synesthetic color choice for the Japanese logographic script, Kanji, were studied. The study investigated how synesthetic colors for Kanji characters, which are usually acquired later in life than other types of graphemes in Japanese language (phonetic characters called Hiragana and Katakana, and Arabic digits), are influenced by linguistic properties such as phonology, orthography, and meaning. Of central interest was a hypothesized generalization process from synesthetic colors for graphemes, learned prior to acquisition of Kanji, to Kanji characters learned later. Results revealed that color choices for Kanji characters depend on meaning and phonological information. Some results suggested that colors are generalized from Hiragana characters and Arabic digits to Kanji characters via phonology and meaning, respectively. Little influence of orthographic information was observed. The findings and approach of this study contributes to a clarification of the mechanism underlying grapheme-color synesthesia, especially in terms of its relationship to normal language processing. Copyright © 2012 Elsevier Inc. All rights reserved.

Learning about natural variation of odor mixtures enhances categorization in early olfactory processing.

PubMed

Locatelli, Fernando F; Fernandez, Patricia C; Smith, Brian H

2016-09-01

Natural odors are typically mixtures of several chemical components. Mixtures vary in composition among odor objects that have the same meaning. Therefore a central 'categorization' problem for an animal as it makes decisions about odors in natural contexts is to correctly identify odor variants that have the same meaning and avoid variants that have a different meaning. We propose that identified mechanisms of associative and non-associative plasticity in early sensory processing in the insect antennal lobe and mammalian olfactory bulb are central to solving this problem. Accordingly, this plasticity should work to improve categorization of odors that have the opposite meanings in relation to important events. Using synthetic mixtures designed to mimic natural odor variation among flowers, we studied how honey bees learn about and generalize among floral odors associated with food. We behaviorally conditioned honey bees on a difficult odor discrimination problem using synthetic mixtures that mimic natural variation among snapdragon flowers. We then used calcium imaging to measure responses of projection neurons of the antennal lobe, which is the first synaptic relay of olfactory sensory information in the brain, to study how ensembles of projection neurons change as a result of behavioral conditioning. We show how these ensembles become 'tuned' through plasticity to improve categorization of odors that have the different meanings. We argue that this tuning allows more efficient use of the immense coding space of the antennal lobe and olfactory bulb to solve the categorization problem. Our data point to the need for a better understanding of the 'statistics' of the odor space. © 2016. Published by The Company of Biologists Ltd.

Mismatch negativity as a potential neurobiological marker of early-stage Alzheimer disease and vascular dementia.

PubMed

Jiang, Shixiang; Yan, Chang; Qiao, Zhengxue; Yao, Haiqian; Jiang, Shiquan; Qiu, Xiaohui; Yang, Xiuxian; Fang, Deyu; Yang, Yanjie; Zhang, Limei; Wang, Lina; Zhang, Liming

2017-04-24

Alzheimer's disease (AD) and vascular dementia (VD) are serious, irreversible forms of cognitive impairment, which means that an early diagnosis is essential to slow down their progression. One potential neurophysiological biomarker of these diseases is the mismatch negativity (MMN) event-related potentials (ERP) component, which reflects an automatic detection mechanism at the pre-attentive stages of information processing. We evaluated the auditory MMN response in individuals from two patient groups: those in the prodromal stages of AD (P-AD) and those in the prodromal stages of VD (P-VD). Thirty patients (15 P-AD patients and 15 P-VD patients) and 30 age-matched controls were recruited to undergo electrophysiological recordings during the presentation of an auditory deviant-standard-reverse oddball paradigm that was used to elicit genuine MMN responses. We show that over the frontal-central area, the mean amplitude of the MMN was significantly reduced in both the P-AD (p=0.017) and P-VD groups (p=0.013) compared with controls. The MMN peak latency in P-VD patients was significantly shorter than in controls (p=0.027). No MMN response differences between the P-AD and P-VD were found in either the frontal-central or the temporal areas. These results indicate that P-AD and P-VD patients exhibit impaired pre-attentive information processing mechanisms as revealed by the frontal-central area MMN response, which is associated with sensory memory and cognitive deficits. Copyright © 2017 Elsevier B.V. All rights reserved.

Processing of Positive-Causal and Negative-Causal Coherence Relations in Primary School Children and Adults: A Test of the Cumulative Cognitive Complexity Approach in German

ERIC Educational Resources Information Center

Knoepke, Julia; Richter, Tobias; Isberner, Maj-Britt; Naumann, Johannes; Neeb, Yvonne; Weinert, Sabine

2017-01-01

Establishing local coherence relations is central to text comprehension. Positive-causal coherence relations link a cause and its consequence, whereas negative-causal coherence relations add a contrastive meaning (negation) to the causal link. According to the cumulative cognitive complexity approach, negative-causal coherence relations are…

Foundations for a Lifetime: A Qualitative Inquiry into the Recollection, Reconstruction and Meaning-Making Process of Cadaver Dissection

ERIC Educational Resources Information Center

Skinner, Michelle D.

2013-01-01

Cadaver dissection has been a central part of the education of medical professionals for centuries. Throughout that time, anatomists have claimed that dissection is a learning experience rich with life lessons encompassing more than simply gross anatomy. Yet, no published empirical data exist of the long-term impact that dissection has on medical…

Electromagnetic tornadoes in space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, T.; Crew, G.B.; Retterer, J.M.

1988-01-01

The exotic phenomenon of energetic-ion conic formation by plasma waves in the magnetosphere is considered. Two particular transverse heating mechanisms are reviewed in detail; lower-hybrid energization of ions in the boundary layer of the plasma sheet and electromagnetic ion cyclotron resonance heating in the central region of the plasma sheet. Mean particle calculations, plasma simulations and analytical treatments of the heating processes are described.

Fostering Transformative Learning: The Role of the Professors and Students of the University of Prishtina

ERIC Educational Resources Information Center

Tahiri, Afredita

2010-01-01

The author discuses transformative learning as a means to explore the centrality of experiences, provide critical reflection, and a rational discourse to examine a set of conditions which need to be fulfilled to foster the application of the transformative learning process for professors and the students at the University of Prishtina. The author…

Application of a linked stress release model in Corinth Gulf and Central Ionian Islands (Greece)

NASA Astrophysics Data System (ADS)

Mangira, Ourania; Vasiliadis, Georgios; Papadimitriou, Eleftheria

2017-06-01

Spatio-temporal stress changes and interactions between adjacent fault segments consist of the most important component in seismic hazard assessment, as they can alter the occurrence probability of strong earthquake onto these segments. The investigation of the interactions between adjacent areas by means of the linked stress release model is attempted for moderate earthquakes ( M ≥ 5.2) in the Corinth Gulf and the Central Ionian Islands (Greece). The study areas were divided in two subareas, based on seismotectonic criteria. The seismicity of each subarea is investigated by means of a stochastic point process and its behavior is determined by the conditional intensity function, which usually gets an exponential form. A conditional intensity function of Weibull form is used for identifying the most appropriate among the models (simple, independent and linked stress release model) for the interpretation of the earthquake generation process. The appropriateness of the models was decided after evaluation via the Akaike information criterion. Despite the fact that the curves of the conditional intensity functions exhibit similar behavior, the use of the exponential-type conditional intensity function seems to fit better the data.

The measurement of retardation in depression.

PubMed

Dantchev, N; Widlöcher, D J

1998-01-01

The description of clinical features helps to distinguish between depressive illness and nondepressive psychic pain and enables the clinician to decide whether prescription of an antidepressant is beneficial. Psychomotor retardation is probably a central feature of depression, and this review discusses the methods available for measuring it. The Salpêtrière Retardation Rating Scale (SRRS) specifically measures psychomotor retardation; the scale and applications are described. Means of measuring motor and speech activity and an experimental approach for understanding the process underlying psychomotor retardation are reviewed. Comparison of the SRRS and other rating scale scores demonstrates that retardation is related to depression severity and therapeutic change and is a good criterion for prediction of therapeutic effect. The SRRS has been used to show that selective antidepressants target specific clinical dimensions of depression depending on the patient subgroup treated. Measures of motor and speech activity are sensitive to therapeutic response. Choice Reaction Time and Simple Reaction Time tasks are particularly suited for examining psychomotor retardation because they test the decision process while avoiding motivation and attention interference. Psychomotor retardation is a constant and probably central feature of depression. Means available for measuring it can be used to assess the effects of antidepressants on specific clinical dimensions.

Contextual Processing of Abstract Concepts Reveals Neural Representations of Non-Linguistic Semantic Content

PubMed Central

Wilson-Mendenhall, Christine D.; Simmons, W. Kyle; Martin, Alex; Barsalou, Lawrence W.

2014-01-01

Concepts develop for many aspects of experience, including abstract internal states and abstract social activities that do not refer to concrete entities in the world. The current study assessed the hypothesis that, like concrete concepts, distributed neural patterns of relevant, non-linguistic semantic content represent the meanings of abstract concepts. In a novel neuroimaging paradigm, participants processed two abstract concepts (convince, arithmetic) and two concrete concepts (rolling, red) deeply and repeatedly during a concept-scene matching task that grounded each concept in typical contexts. Using a catch trial design, neural activity associated with each concept word was separated from neural activity associated with subsequent visual scenes to assess activations underlying the detailed semantics of each concept. We predicted that brain regions underlying mentalizing and social cognition (e.g., medial prefrontal cortex, superior temporal sulcus) would become active to represent semantic content central to convince, whereas brain regions underlying numerical cognition (e.g., bilateral intraparietal sulcus) would become active to represent semantic content central to arithmetic. The results supported these predictions, suggesting that the meanings of abstract concepts arise from distributed neural systems that represent concept-specific content. PMID:23363408

Quantitative Analyse von Korallengemeinschaften des Sanganeb-Atolls (mittleres Rotes Meer). II. Vergleich mit einem Riffareal bei Aqaba (nördliches Rotes Meer) am Nordrande des indopazifischen Riffgürtels

NASA Astrophysics Data System (ADS)

Schuhmacher, H.; Mergner, H.

1985-12-01

Quantitative studies of coral communities in the central and northern Red Sea were designed for comparison of the community structure in both areas. The central Red Sea provides reef-building Scleractinia and reef-inhabiting Alcyonaria with optimal temperature conditions, whereas the north tip of the Gulf of Aqaba (29°30' N) represents the northernmost outpost of coral reefs in the Indian Ocean. It is generally assumed that coral diversity decreases towards the margins of the global reef-belt. In the Red Sea, generic diversity of hermatypic Scleractinia slightly decreases from the central to the northern part (51 : 48 genera); but cnidarian species abundance (species number per 25 m2 area) was found to increase from 62 to 98 species and the Shannon-Wiener diversity index increased from 2.58 to 3.67 with regard to colony number. The mean colony size was 189 cm2 at Sanganeb-Atoll, but only 52 cm2 at Aqaba. The mean numbers of colonies were inversely related: 662 per 25 m2 at Sanganeb-Atoll and 2028 at Aqaba. Uninhabited parts of the studied areas amounted to 47 % at Sanganeb-Atoll and to 56 % at Aqaba. The community structure of the studied areas indicates that occasional perturbations prevent the progress of the community towards a low-diversity equilibrium state. Since severe hydrodynamic damage is extremely rare in 10 m depth, major disturbances may occur by sedimentation, by the interference of grazers (e. g. Diadema setosum) and due to overgrowth by space-competitors (mainly soft corals). These events are to be regarded as throwbacks in the process of monopolization of the area by well adapted species. Recovery from such perturbations (i.e. recolonization of dead areas) obviously takes place at different velocities in the northern and central Red Sea, for the mean water temperature at Aqaba is 5 °C lower than in the central Red Sea. Hence the process of taking over a given space by a few species proceeds further in the central Red Sea than at its northern end. The increase in diversity per area towards high latitudes is comparable to that with depth. It is concluded from the great number of species at Aqaba that these reefs mark the northernmost outpost of the Indian Ocean only geographically but not ecophysiologically; they would occur at even higher latitudes, if the Gulf of Aqaba extended farther north.

32 CFR 1901.02 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE... meanings indicated: (a) Agency or CIA means the United States Central Intelligence Agency acting through... individual that is maintained by the Central Intelligence Agency in a system of records; (k) Requester or...

32 CFR 1901.02 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE... meanings indicated: (a) Agency or CIA means the United States Central Intelligence Agency acting through... individual that is maintained by the Central Intelligence Agency in a system of records; (k) Requester or...

Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass: A Prospective Multicenter Study.

PubMed

Weber, Thomas; Wassertheurer, Siegfried; Schmidt-Trucksäss, Arno; Rodilla, Enrique; Ablasser, Cornelia; Jankowski, Piotr; Lorenza Muiesan, Maria; Giannattasio, Cristina; Mang, Claudia; Wilkinson, Ian; Kellermair, Jörg; Hametner, Bernhard; Pascual, Jose Maria; Zweiker, Robert; Czarnecka, Danuta; Paini, Anna; Salvetti, Massimo; Maloberti, Alessandro; McEniery, Carmel

2017-12-01

We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ambulatory systolic pressures were 127 and 128 mm Hg, respectively. Mean left ventricular mass was 93.3 kg/m 2 , and 25.6% had left ventricular hypertrophy. The correlation coefficient between left ventricular mass and brachial office, brachial ambulatory, and central ambulatory systolic pressure was 0.29, 0.41, and 0.47, respectively ( P =0.003 for comparison between brachial office and central ambulatory systolic pressure and 0.32 for comparison between brachial and central ambulatory systolic pressure). The results were consistent for men and women, and young and old participants. The areas under the curve for prediction of left ventricular hypertrophy were 0.618, 0.635, and 0.666 for brachial office, brachial, and central ambulatory systolic pressure, respectively ( P =0.03 for comparison between brachial and central ambulatory systolic pressure). In younger participants, central ambulatory systolic pressure was superior to both other measurements. Central ambulatory systolic pressure, measured with an oscillometric cuff, shows a strong trend toward a closer association with left ventricular mass and hypertrophy than brachial office/ambulatory systolic pressure. URL: https://www.clinicaltrials.gov. Unique identifier: NCT01278732. © 2017 American Heart Association, Inc.

Pathophysiology and Toxicokinetic Studies of Blue-Green Algae Intoxication in the Swine Model

DTIC Science & Technology

1991-06-26

perfusion, renal perfusion, and mean arterial and central venous pressures were decreased, and portal pressure increased. Liver iron and hemoglobin indicated...the lethal dose, aortic mean pressure and central venous pressure decreased significantly, while portal venous pressure significantly increased. The...8217" recorded on a poiygraphY and logged on a hemodynamic analyzer.𔄁 Mean aortic, central venous , and portal venous pressures were determined predosing

Integrated structural model for active arc-continental collision from southern Taiwan to central Taiwan inferred from seismogenic views

NASA Astrophysics Data System (ADS)

Nagai, S.; Wang, Y.; Ma, K.; Wu, Y.; Huang, H.

2010-12-01

The Taiwan Island is located in ongoing arc-continent collision zone between the Philippine Sea Plate and the Eurasian Plate. Numerous geophysical and geological studies have explained the tectonic processes and developed various models. There are two end-member models for Taiwan collision; Thin-skinned model [e.g. Suppe, 1987] and Lithospheric collision model [Wu et al., 1997]. One of most important issue is that collision in Taiwan involves and contributes deformation to what depth. We have presented on this point in central Taiwan through seismological views, including both observed facts and results of tomographic inversion [Nagai et al., 2010 in WPGM 2010]. We have concluded that orogenic process should involve and contribute to depth of 30 km at least in central Taiwan, and suggested ’Upper Crustal Stacking Model’. We have indicated that existence of low-velocity blocks under Central Mountain Range (CMR) is one of the most important factors to understand Taiwan arc-continental collision process. We extend this idea to southern and northern Taiwan and to connect with balanced cross-sections proposed in Ustaszewski et al. [2010]. In this talk, we focused on the structural variation from southern Taiwan to central Taiwan. We have been performing the local double-difference tomography [Zhang and Thurber, 2003] in southern and northern Taiwan using the Central Weather Bureau Seismic Network with temporary array observations. These results in seismic tomography show variation of seismic velocity under the CMR like in central Taiwan. Low-velocity anomalies are also detected. Although it should be checked carefully, velocity blocks segmented some parts and seismic activities seem to be located on their boundaries. The Jiaxian earthquake on 4th Mar, 2010 occurred on one of these segmentation boundaries. The tectonic process in Taiwan arc-continental collision consists of different-scale structures, which means finer resolution structures may be nested with the larger ones. The thin-skinned model is the first step and the finest structural model in collision process, dominated in south and western Taiwan. After thin-skinned process, processes in the UCS model deformed and pushed up these finest structures in thin-skinned model, and then eroded on the CMR. Although this idea for integrated model for Taiwan orogeny should be verified more through geological and geophysical views both, it is pretty simple and can explain many features among various models between two end-members. Previous presentation for central Taiwan Nagai et al., (2010), Integrated structural model for arc-continent collision in Taiwan inferred from seismic velocity, relocated seismicity, and attenuation inverted by seismic tomography, Eos Trans. AGU, 91(26), West. Pac. Geophys. Meet. Suppl., Abstract T22A-06.

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwun, Hyun Jin; Ramos da Silva, Suzane; Department of Pathology, Botucatu School of Medicine at Sao Paulo State University, Sao Paulo

KSHV LANA1, a latent protein expressed during chronic infection to maintain a viral genome, inhibits major histocompatibility complex class I (MHC I) peptide presentation in cis as a means of immune evasion. Through deletional cloning, we localized this function to the LANA1 central repeat 1 (CR1) subregion. Other CR subregions retard LANA1 translation and proteasomal processing but do not markedly inhibit LANA1 peptide processing by MHC I. Inhibition of proteasomal processing ablates LANA1 peptide presentation. Direct expression of LANA1 within the endoplasmic reticulum (ER) overcomes CR1 inhibition suggesting that CR1 acts prior to translocation of cytoplasmic peptides into the ER.more » By physically separating CR1 from other subdomains, we show that LANA1 evades MHC I peptide processing by a mechanism distinct from other herpesviruses including Epstein-Barr virus (EBV). Although LANA1 and EBV EBNA1 are functionally similar, they appear to use different mechanisms to evade host cytotoxic T lymphocyte surveillance.« less

[Adaptation of control mechanisms involved in upright undisturbed stance maintenance during prolonged darkness].

PubMed

Rougier, P

2003-04-01

To assess to which extent the non visual somato-sensorial information may, through a recalibration process, induce a reorganisation by the central nervous system to control undisturbed upright stance. Ten healthy adults were placed in complete darkness for a 24 min period. Their postural performance was recorded through a force platform on which they were required to stand still at regular intervals. Centre of Pressure (CP) displacements, recorded from the platform, were modelled as fractional brownian motion. Through this analysis, one may objectively assess from which distance and for how long the corrective process is initiated with the aim of slowing and retrace its steps. In addition, the degree to which the CP trajectories are successively controlled was determined. Once in complete darkness, an increase of the mean time intervals (Delta(t)) before the corrective process intervenes was observed, the effect being mostly significant for the mediolateral direction. In parallel, the mean distances covered at this Delta(t) were slightly affected for both mediolateral and anteroposterior directions. Lastly, the degree to which the CP trajectories are controlled tended to decrease. These data suggest a reorganisation of the control mechanisms called into play for maintaining an undisturbed upright stance, thus implying participation of the central nervous system. This short-term adaptation is discussed on the basis of our knowledge of long term adaptations previously observed in blind individuals, and also in a rehabilitation perspective.

Narrating consciousness: language, media and embodiment.

PubMed

Hayles, N Katherine; Pulizzi, James J

2010-01-01

Although there has long been a division in studies of consciousness between a focus on neuronal processes or conversely an emphasis on the ruminations of a conscious self, the long-standing split between mechanism and meaning within the brain was mirrored by a split without, between information as a technical term and the meanings that messages are commonly thought to convey. How to heal this breach has posed formidable problems to researchers. Working through the history of cybernetics, one of the historical sites where Claude Shannon's information theory quickly became received doctrine, we argue that the cybernetic program as it developed through second-order cybernetics and autopoietic theory remains incomplete. In this article, we return to fundamental questions about pattern and noise, context and meaning, to forge connections between consciousness, narrative and media. The thrust of our project is to reintroduce context and narrative as crucial factors in the processes of meaning-making. The project proceeds along two fronts: advancing a theoretical framework within which context plays its property central role; and demonstrating the importance of context by analyzing two fictions, Stanislaw Lem's "His Master's Voice" and Joseph McElroy's "Plus," in which context has been deformed by being wrenched away from normal human environments, with radical consequences for processes of meaning-making.

Exit, cohesion, and consensus: social psychological moderators of consensus among adolescent peer groups

PubMed Central

Fisher, Jacob C.

2017-01-01

Virtually all social diffusion work relies on a common formal basis, which predicts that consensus will develop among a connected population as the result of diffusion. In spite of the popularity of social diffusion models that predict consensus, few empirical studies examine consensus, or a clustering of attitudes, directly. Those that do either focus on the coordinating role of strict hierarchies, or on the results of online experiments, and do not consider how consensus occurs among groups in situ. This study uses longitudinal data on adolescent social networks to show how meso-level social structures, such as informal peer groups, moderate the process of consensus formation. Using a novel method for controlling for selection into a group, I find that centralized peer groups, meaning groups with clear leaders, have very low levels of consensus, while cohesive peer groups, meaning groups where more ties hold the members of the group together, have very high levels of consensus. This finding is robust to two different measures of cohesion and consensus. This suggests that consensus occurs either through central leaders’ enforcement or through diffusion of attitudes, but that central leaders have limited ability to enforce when people can leave the group easily. PMID:29335675

The analysis of aridity in Central Serbia from 1949 to 2015

NASA Astrophysics Data System (ADS)

Radaković, Milica G.; Tošić, Ivana; Bačević, Nikola; Mladjan, Dragan; Gavrilov, Milivoj B.; Marković, Slobodan B.

2017-07-01

In this study, we apply De Martonne and Pinna combinative indices to analyze the aridity in Central Serbia. Our dataset consists of mean monthly surface air temperature (MMT) and mean monthly precipitation (MMP) for 26 meteorological stations during the period 1949-2015. MMT and MMP are used for calculating monthly, seasonal, and annual aridity indices for period of 66 years. According to the De Martonne climate classification, we determine five, three, and four types of climate on the monthly, seasonal, and annual basis, respectively. During the observed period, winter was extremely humid, spring and autumn were humid, and summer was semi-humid. Humid and semi-humid climate with Mediterranean vegetation are identified by the annual Pinna combinative index. We find that there is no change in aridity trend in Central Serbia for the period 1949-2015. Aridity indices are additionally compared with the North Atlantic Oscillation and El-Niño South Oscillation in order to establish a possible connection with the large-scale processes. Results are further compared with several earlier studies of aridity in Serbia. With this study, the analysis of aridity in whole Serbia has become complete.

Composing Models of Geographic Physical Processes

NASA Astrophysics Data System (ADS)

Hofer, Barbara; Frank, Andrew U.

Processes are central for geographic information science; yet geographic information systems (GIS) lack capabilities to represent process related information. A prerequisite to including processes in GIS software is a general method to describe geographic processes independently of application disciplines. This paper presents such a method, namely a process description language. The vocabulary of the process description language is derived formally from mathematical models. Physical processes in geography can be described in two equivalent languages: partial differential equations or partial difference equations, where the latter can be shown graphically and used as a method for application specialists to enter their process models. The vocabulary of the process description language comprises components for describing the general behavior of prototypical geographic physical processes. These process components can be composed by basic models of geographic physical processes, which is shown by means of an example.

Growing season net ecosystem CO2 exchange of two desert ecosystems with alkaline soils in Kazakhstan.

PubMed

Li, Longhui; Chen, Xi; van der Tol, Christiaan; Luo, Geping; Su, Zhongbo

2014-01-01

Central Asia is covered by vast desert ecosystems, and the majority of these ecosystems have alkaline soils. Their contribution to global net ecosystem CO2 exchange (NEE) is of significance simply because of their immense spatial extent. Some of the latest research reported considerable abiotic CO2 absorption by alkaline soil, but the rate of CO2 absorption has been questioned by peer communities. To investigate the issue of carbon cycle in Central Asian desert ecosystems with alkaline soils, we have measured the NEE using eddy covariance (EC) method at two alkaline sites during growing season in Kazakhstan. The diurnal course of mean monthly NEE followed a clear sinusoidal pattern during growing season at both sites. Both sites showed significant net carbon uptake during daytime on sunny days with high photosynthetically active radiation (PAR) but net carbon loss at nighttime and on cloudy and rainy days. NEE has strong dependency on PAR and the response of NEE to precipitation resulted in an initial and significant carbon release to the atmosphere, similar to other ecosystems. These findings indicate that biotic processes dominated the carbon processes, and the contribution of abiotic carbon process to net ecosystem CO2 exchange may be trivial in alkaline soil desert ecosystems over Central Asia.

Growing season net ecosystem CO2 exchange of two desert ecosystems with alkaline soils in Kazakhstan

PubMed Central

Li, Longhui; Chen, Xi; van der Tol, Christiaan; Luo, Geping; Su, Zhongbo

2014-01-01

Central Asia is covered by vast desert ecosystems, and the majority of these ecosystems have alkaline soils. Their contribution to global net ecosystem CO2 exchange (NEE) is of significance simply because of their immense spatial extent. Some of the latest research reported considerable abiotic CO2 absorption by alkaline soil, but the rate of CO2 absorption has been questioned by peer communities. To investigate the issue of carbon cycle in Central Asian desert ecosystems with alkaline soils, we have measured the NEE using eddy covariance (EC) method at two alkaline sites during growing season in Kazakhstan. The diurnal course of mean monthly NEE followed a clear sinusoidal pattern during growing season at both sites. Both sites showed significant net carbon uptake during daytime on sunny days with high photosynthetically active radiation (PAR) but net carbon loss at nighttime and on cloudy and rainy days. NEE has strong dependency on PAR and the response of NEE to precipitation resulted in an initial and significant carbon release to the atmosphere, similar to other ecosystems. These findings indicate that biotic processes dominated the carbon processes, and the contribution of abiotic carbon process to net ecosystem CO2 exchange may be trivial in alkaline soil desert ecosystems over Central Asia. PMID:24455157

Bringing central line-associated bloodstream infection prevention home: CLABSI definitions and prevention policies in home health care agencies.

PubMed

Rinke, Michael L; Bundy, David G; Milstone, Aaron M; Deuber, Kristin; Chen, Allen R; Colantuoni, Elizabeth; Miller, Marlene R

2013-08-01

A study was conducted to investigate health care agency central line-associated bloodstream infection (CLABSI) definitions and prevention policies and pare them to the Joint Commission National Patient Safety Goal (NPSG.07.04.01), the Centers for Disease Control and Prevention (CDC) CLABSI prevention recommendations, and a best-practice central line care bundle for inpatients. A telephone-based survey was conducted in 2011 of a convenience sample of home health care agencies associated with children's hematology/oncology centers. Of the 97 eligible home health care agencies, 57 (59%) completed the survey. No agency reported using all five aspects of the National Healthcare and Safety Network/Association for Professionals in Infection Control and Epidemiology CLABSI definition and adjudication process, and of the 50 agencies that reported tracking CLABSI rates, 20 (40%) reported using none. Only 10 agencies (18%) had policies consistent with all elements of the inpatient-focused NPSG.07.04.01, 10 agencies (18%) were consistent with all elements of the home care targeted CDC CLABSI prevention recommendations, and no agencies were consistent with all elements of the central line care bundle. Only 14 agencies (25%) knew their overall CLABSI rate: mean 0.40 CLABSIs per 1,000 central line days (95% confidence interval [CI], 0.18 to 0.61). Six agencies (11%) knew their agency's pediatric CLABSI rate: mean 0.54 CLABSIs per 1,000 central line days (95% CI, 0.06 to 1.01). The policies of a national sample of home health care agencies varied significantly from national inpatient and home health care agency targeted standards for CLABSI definitions and prevention. Future research should assess strategies for standardizing home health care practices consistent with evidence-based recommendations.

Goals for Business Operations and Family Life. The Retailer's Tool Kit and Instructor's Guide. North Central Regional Extension Publications #285 and #288.

ERIC Educational Resources Information Center

Gessaman, Paul H.

This packet contains student materials and an instructor's guide for use in a series of workshops on the "GOALS Process" for persons in retail businesses. The materials provide a framework for individual or family use in self-assessment and a means of identifying business and family life goals, setting priorities, and developing management…

ONR Far East Scientific Information Bulletin. Volume 14, Number 1. HEISEI, Achieving Universal Peace

DTIC Science & Technology

1989-03-01

grounding gated for basic and central meanings, traced in the Western classics and Indo-European for subsequent etymological development, comparative...controlled properties at reasonable costs. diamond films, processing conditions for Diamond for industrial applications the fabrication of diamond films... applications such as diamondlike films, are beginning to reach heat sinks will also become economically the industrial marketplace. The precise

Adaptation of vestibular signals for self-motion perception

PubMed Central

St George, Rebecca J; Day, Brian L; Fitzpatrick, Richard C

2011-01-01

A fundamental concern of the brain is to establish the spatial relationship between self and the world to allow purposeful action. Response adaptation to unvarying sensory stimuli is a common feature of neural processing, both peripherally and centrally. For the semicircular canals, peripheral adaptation of the canal-cupula system to constant angular-velocity stimuli dominates the picture and masks central adaptation. Here we ask whether galvanic vestibular stimulation circumvents peripheral adaptation and, if so, does it reveal central adaptive processes. Transmastoidal bipolar galvanic stimulation and platform rotation (20 deg s−1) were applied separately and held constant for 2 min while perceived rotation was measured by verbal report. During real rotation, the perception of turn decayed from the onset of constant velocity with a mean time constant of 15.8 s. During galvanic-evoked virtual rotation, the perception of rotation initially rose but then declined towards zero over a period of ∼100 s. For both stimuli, oppositely directed perceptions of similar amplitude were reported when stimulation ceased indicating signal adaptation at some level. From these data the time constants of three independent processes were estimated: (i) the peripheral canal-cupula adaptation with time constant 7.3 s, (ii) the central ‘velocity-storage’ process that extends the afferent signal with time constant 7.7 s, and (iii) a long-term adaptation with time constant 75.9 s. The first two agree with previous data based on constant-velocity stimuli. The third component decayed with the profile of a real constant angular acceleration stimulus, showing that the galvanic stimulus signal bypasses the peripheral transformation so that the brainstem sees the galvanic signal as angular acceleration. An adaptive process involving both peripheral and central processes is indicated. Signals evoked by most natural movements will decay peripherally before adaptation can exert an appreciable effect, making a specific vestibular behavioural role unlikely. This adaptation appears to be a general property of the internal coding of self-motion that receives information from multiple sensory sources and filters out the unvarying components regardless of their origin. In this instance of a pure vestibular sensation, it defines the afferent signal that represents the stationary or zero-rotation state. PMID:20937715

Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H+-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8

PubMed Central

Yano, Kanako; Yanagisawa, Takahiro; Mukae, Kyosuke; Niwa, Yasuo; Inoue, Yuko; Moriyasu, Yuji

2015-01-01

Tobacco BY-2 cells undergo autophagy in sucrose-free culture medium, which is the process mostly responsible for intracellular protein degradation under these conditions. Autophagy was inhibited by the vacuolar H+-ATPase inhibitors concanamycin A and bafilomycin A1, which caused the accumulation of autophagic bodies in the central vacuoles. Such accumulation did not occur in the presence of the autophagy inhibitor 3-methyladenine, and concanamycin in turn inhibited the accumulation of autolysosomes in the presence of the cysteine protease inhibitor E-64c. Electron microscopy revealed not only that the autophagic bodies were accumulated in the central vacuole, but also that autophagosome-like structures were more frequently observed in the cytoplasm in treatments with concanamycin, suggesting that concanamycin affects the morphology of autophagosomes in addition to raising the pH of the central vacuole. Using BY-2 cells that constitutively express a fusion protein of autophagosome marker protein Atg8 and green fluorescent protein (GFP), we observed the appearance of autophagosomes by fluorescence microscopy, which is a reliable morphological marker of autophagy, and the processing of the fusion protein to GFP, which is a biochemical marker of autophagy. Together, these results suggest the involvement of vacuole type H+-ATPase in the maturation step of autophagosomes to autolysosomes in the autophagic process of BY-2 cells. The accumulation of autophagic bodies in the central vacuole by concanamycin is a marker of the occurrence of autophagy; however, it does not necessarily mean that the central vacuole is the site of cytoplasm degradation. PMID:26368310

Pragmatics in acquisition.

PubMed

Clark, Eve V

2014-07-01

Recent research has highlighted several areas where pragmatics plays a central role in the process of acquiring a first language. In talking with their children, adults display their uses of language in each context, and offer extensive feedback on form, meaning, and usage, within their conversational exchanges. These interactions depend critically on joint attention, physical co-presence, and conversational co-presence - essential factors that help children assign meanings, establish reference, and add to common ground. For young children, getting their meaning across also depends on realizing language is conventional, that words contrast in meaning, and that they need to observe Grice's cooperative principle in conversation. Adults make use of the same pragmatic principles as they solicit repairs to what children say, and thereby offer feedback on both what the language is and how to use it.

Changing to Concept-Based Curricula: The Process for Nurse Educators.

PubMed

Baron, Kristy A

2017-01-01

The complexity of health care today requires nursing graduates to use effective thinking skills. Many nursing programs are revising curricula to include concept-based learning that encourages problem-solving, effective thinking, and the ability to transfer knowledge to a variety of situations-requiring nurse educators to modify their teaching styles and methods to promote student-centered learning. Changing from teacher-centered learning to student-centered learning requires a major shift in thinking and application. The focus of this qualitative study was to understand the process of changing to concept-based curricula for nurse educators who previously taught in traditional curriculum designs. The sample included eight educators from two institutions in one Western state using a grounded theory design. The themes that emerged from participants' experiences consisted of the overarching concept, support for change, and central concept, finding meaning in the change. Finding meaning is supported by three main themes : preparing for the change, teaching in a concept-based curriculum, and understanding the teaching-learning process. Changing to a concept-based curriculum required a major shift in thinking and application. Through support, educators discovered meaning to make the change by constructing authentic learning opportunities that mirrored practice, refining the change process, and reinforcing benefits of teaching.

Choice.

PubMed

Greenberg, Jay

2008-09-01

Understanding how and why analysands make the choices they do is central to both the clinical and the theoretical projects of psychoanalysis. And yet we know very little about the process of choice or about the relationship between choices and motives. A striking parallel is to be found between the ways choice is narrated in ancient Greek texts and the experience of analysts as they observe patients making choices in everyday clinical work. Pursuing this convergence of classical and contemporary sensibilities will illuminate crucial elements of the various meanings of choice, and of the way that these meanings change over the course of psychoanalytic treatment.

Unexplained Discontinuity in the US Radiosonde Temperature Data. Part 2; Stratosphere

NASA Technical Reports Server (NTRS)

Redder, Christopher R.; Luers, Jim K.; Eskridge, Robert E.

2003-01-01

In part I of this paper, the United States (US) radiosonde temperature data are shown to have significant and unexplained inhomogeneities in the mid-troposphere. This part discusses the differences between observations taken at 0 and 12 UTC especially in the stratosphere by the Vaisala RS80 radiosondes that are integrated within the National Weather Service's (NWS) Micro-ART system. The results show that there is a large maxima in the horizontal distribution of the monthly means of the 0/12 UTC differences over the central US that is absent over Canada and this maxima is as large as 5 C at 10 hPa. The vertical profiles of the root-mean-square of the monthly means are much larger in the US than those else where. The data clearly shows that the 0/12 UTC differences are largely artificial especially over the central US and originate in the post processing software at observing stations, thus confirming the findings in part I. Special flight data from the NWS's test facility at Sterling, Va. have been obtained. This data can be used to deduce the bias correction applied by Vaisala's post processing system. By analyzing the correction data, it can be shown that the inconsistencies with non-US Vaisala RS80 data as well as most of the large 0/12 UTC differences over the US can be accounted for by multiplying the reported elapsed time (i.e. time since launch) by the factor which is incorrectly applied by the post processing software. After being presented with the findings in this paper, Vaisala further isolated the source of the inconsistencies to a software coding error in the radiation bias correction scheme. The error effects only the software installed at US stations.

Mechanisms of Tooth Eruption and Orthodontic Tooth Movement

PubMed Central

Wise, G.E.; King, G.J.

2008-01-01

Teeth move through alveolar bone, whether through the normal process of tooth eruption or by strains generated by orthodontic appliances. Both eruption and orthodontics accomplish this feat through similar fundamental biological processes, osteoclastogenesis and osteogenesis, but there are differences that make their mechanisms unique. A better appreciation of the molecular and cellular events that regulate osteoclastogenesis and osteogenesis in eruption and orthodontics is not only central to our understanding of how these processes occur, but also is needed for ultimate development of the means to control them. Possible future studies in these areas are also discussed, with particular emphasis on translation of fundamental knowledge to improve dental treatments. PMID:18434571

Drainage morphometric analysis for assessing form and processes of the watersheds of Pachamalai hills and its adjoinings, Central Tamil Nadu, India

NASA Astrophysics Data System (ADS)

Prabhakaran, A.; Jawahar Raj, N.

2018-03-01

The present study attempts to understand the form and geomorphic/hydrologic processes of the 20 watersheds of the Pachamalai hills and its adjoinings located in Tamil Nadu State of southern India from the analysis of its drainage morphometric characteristics. Survey of India's topographic sheets of 1:50,000 is the data source from which stream networks and watersheds of the study area were demarcated followed by the analysis of their morphometric characteristics using ArcGIS software. The results of the analysis formed the basis for deducing the form and processes of the watersheds of the study area. The form of the watersheds inferred from the analysis includes shape, length, slope steepness and length, degree of branching of streams, dissection and elongation of watersheds. The geomorphic/hydrologic processes inferred include denudation rate, potential energy, intensity of erosion, mean annual run off, mean discharge, discharge rate, rock resistivity and infiltration potential, amount of sediment transported, mean annual rainfall, rainfall intensity, lagtime, flash flood potential, flood discharge per unit area, sediment yield and speed of the water flow in the streams. The understanding of variations of form and processes mentioned can be used towards prioritizing the watersheds for development, management and conservation planning.

Benefits of a comprehensive quality program for cryopreserved PBMC covering 28 clinical trials sites utilizing an integrated, analytical web-based portal.

PubMed

Ducar, Constance; Smith, Donna; Pinzon, Cris; Stirewalt, Michael; Cooper, Cristine; McElrath, M Juliana; Hural, John

2014-07-01

The HIV Vaccine Trials Network (HVTN) is a global network of 28 clinical trial sites dedicated to identifying an effective HIV vaccine. Cryopreservation of high-quality peripheral blood mononuclear cells (PBMC) is critical for the assessment of vaccine-induced cellular immune functions. The HVTN PBMC Quality Management Program is designed to ensure that viable PBMC are processed, stored and shipped for clinical trial assays from all HVTN clinical trial sites. The program has evolved by developing and incorporating best practices for laboratory and specimen quality and implementing automated, web-based tools. These tools allow the site-affiliated processing laboratories and the central Laboratory Operations Unit to rapidly collect, analyze and report PBMC quality data. The HVTN PBMC Quality Management Program includes five key components: 1) Laboratory Assessment, 2) PBMC Training and Certification, 3) Internal Quality Control, 4) External Quality Control (EQC), and 5) Assay Specimen Quality Control. Fresh PBMC processing data is uploaded from each clinical site processing laboratory to a central HVTN Statistical and Data Management Center database for access and analysis on a web portal. Samples are thawed at a central laboratory for assay or specimen quality control and sample quality data is uploaded directly to the database by the central laboratory. Four year cumulative data covering 23,477 blood draws reveals an average fresh PBMC yield of 1.45×10(6)±0.48 cells per milliliter of useable whole blood. 95% of samples were within the acceptable range for fresh cell yield of 0.8-3.2×10(6) cells/ml of usable blood. Prior to full implementation of the HVTN PBMC Quality Management Program, the 2007 EQC evaluations from 10 international sites showed a mean day 2 thawed viability of 83.1% and a recovery of 67.5%. Since then, four year cumulative data covering 3338 specimens used in immunologic assays shows that 99.88% had acceptable viabilities (>66%) for use in cellular assays (mean, 91.46% ±4.5%), and 96.2% had acceptable recoveries (50%-130%) with a mean of recovery of 85.8% ±19.12% of the originally cryopreserved cells. EQC testing revealed that since August 2009, failed recoveries dropped from 4.1% to 1.6% and failed viabilities dropped from 1.0% to 0.3%. The HVTN PBMC quality program provides for laboratory assessment, training and tools for identifying problems, implementing corrective action and monitoring for improvements. These data support the benefits of implementing a comprehensive, web-based PBMC quality program for large clinical trials networks. Copyright © 2014 Elsevier B.V. All rights reserved.

Sanov and central limit theorems for output statistics of quantum Markov chains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horssen, Merlijn van, E-mail: merlijn.vanhorssen@nottingham.ac.uk; Guţă, Mădălin, E-mail: madalin.guta@nottingham.ac.uk

2015-02-15

In this paper, we consider the statistics of repeated measurements on the output of a quantum Markov chain. We establish a large deviations result analogous to Sanov’s theorem for the multi-site empirical measure associated to finite sequences of consecutive outcomes of a classical stochastic process. Our result relies on the construction of an extended quantum transition operator (which keeps track of previous outcomes) in terms of which we compute moment generating functions, and whose spectral radius is related to the large deviations rate function. As a corollary to this, we obtain a central limit theorem for the empirical measure. Suchmore » higher level statistics may be used to uncover critical behaviour such as dynamical phase transitions, which are not captured by lower level statistics such as the sample mean. As a step in this direction, we give an example of a finite system whose level-1 (empirical mean) rate function is independent of a model parameter while the level-2 (empirical measure) rate is not.« less

Effect of Postural Control Demands on Early Visual Evoked Potentials during a Subjective Visual Vertical Perception Task in Adolescents with Idiopathic Scoliosis.

PubMed

Chang, Yi-Tzu; Meng, Ling-Fu; Chang, Chun-Ju; Lai, Po-Liang; Lung, Chi-Wen; Chern, Jen-Suh

2017-01-01

Subjective visual vertical (SVV) judgment and standing stability were separately investigated among patients with adolescent idiopathic scoliosis (AIS). Although, one study has investigated the central mechanism of stability control in the AIS population, the relationships between SVV, decreased standing stability, and AIS have never been investigated. Through event-related potentials (ERPs), the present study examined the effect of postural control demands (PDs) on AIS central mechanisms related to SVV judgment and standing stability to elucidate the time-serial stability control process. Thirteen AIS subjects (AIS group) and 13 age-matched adolescents (control group) aged 12-18 years were recruited. Each subject had to complete an SVV task (i.e., the modified rod-and-frame [mRAF] test) as a stimulus, with online electroencephalogram recording being performed in the following three standing postures: feet shoulder-width apart standing, feet together standing, and tandem standing. The behavioral performance in terms of postural stability (center of pressure excursion), SVV (accuracy and reaction time), and mRAF-locked ERPs (mean amplitude and peak latency of the P1, N1, and P2 components) was then compared between the AIS and control groups. In the behavioral domain, the results revealed that only the AIS group demonstrated a significantly accelerated SVV reaction time as the PDs increased. In the cerebral domain, significantly larger P2 mean amplitudes were observed during both feet shoulder-width-apart standing and feet together standing postures compared with during tandem standing. No group differences were noted in the cerebral domain. The results indicated that (1) during the dual-task paradigm, a differential behavioral strategy of accelerated SVV reaction time was observed in the AIS group only when the PDs increased and (2) the decrease in P2 mean amplitudes with the increase in the PD levels might be direct evidence of the competition for central processing attentional resources under the dual-task postural control paradigm.

Effect of Postural Control Demands on Early Visual Evoked Potentials during a Subjective Visual Vertical Perception Task in Adolescents with Idiopathic Scoliosis

PubMed Central

Chang, Yi-Tzu; Meng, Ling-Fu; Chang, Chun-Ju; Lai, Po-Liang; Lung, Chi-Wen; Chern, Jen-Suh

2017-01-01

Subjective visual vertical (SVV) judgment and standing stability were separately investigated among patients with adolescent idiopathic scoliosis (AIS). Although, one study has investigated the central mechanism of stability control in the AIS population, the relationships between SVV, decreased standing stability, and AIS have never been investigated. Through event-related potentials (ERPs), the present study examined the effect of postural control demands (PDs) on AIS central mechanisms related to SVV judgment and standing stability to elucidate the time-serial stability control process. Thirteen AIS subjects (AIS group) and 13 age-matched adolescents (control group) aged 12–18 years were recruited. Each subject had to complete an SVV task (i.e., the modified rod-and-frame [mRAF] test) as a stimulus, with online electroencephalogram recording being performed in the following three standing postures: feet shoulder-width apart standing, feet together standing, and tandem standing. The behavioral performance in terms of postural stability (center of pressure excursion), SVV (accuracy and reaction time), and mRAF-locked ERPs (mean amplitude and peak latency of the P1, N1, and P2 components) was then compared between the AIS and control groups. In the behavioral domain, the results revealed that only the AIS group demonstrated a significantly accelerated SVV reaction time as the PDs increased. In the cerebral domain, significantly larger P2 mean amplitudes were observed during both feet shoulder-width-apart standing and feet together standing postures compared with during tandem standing. No group differences were noted in the cerebral domain. The results indicated that (1) during the dual-task paradigm, a differential behavioral strategy of accelerated SVV reaction time was observed in the AIS group only when the PDs increased and (2) the decrease in P2 mean amplitudes with the increase in the PD levels might be direct evidence of the competition for central processing attentional resources under the dual-task postural control paradigm. PMID:28713252

A Methodology for Developing Evidence about Meaning in Occupation: Exploring the Meaning of Working.

ERIC Educational Resources Information Center

Baker, Nancy A.; Jacobs, Karen; Tickle-Degnen, Linda

2003-01-01

The Meaning of Working Survey, with the constructs of work centrality, societal work norms, and valued work outcomes, was completed by 170 workers. They did not view work as central, but as a constraint or reciprocal arrangement. They valued benefits and wages over intrinsic outcomes. Cluster analysis revealed that work meanings were related to…

Primary Teacher's Perceptions of Classroom Assessment Practices as Means of Providing Quality Primary/Basic Education by Botswana and Nigeria

ERIC Educational Resources Information Center

Nenty, H. J.; Adedoyin, O. O.; Odili, John N.; Major, T. E.

2007-01-01

More than any other of its aspects, assessment plays a central role in determining the quality of education. Quality of primary/basic education (QoE) can be viewed as the extent to which the process of education at the primary education level maximizes desirable outcomes in terms of cognitive, affective and psychomotor behaviour of the learners.…

Becoming a Runner: Big, Middle and Small Stories about Physical Activity Participation in Later Life

ERIC Educational Resources Information Center

Griffin, Meridith; Phoenix, Cassandra

2016-01-01

How do older adults learn to tell a "new" story about, through, and with the body? We know that narratives are embodied, lived and central to the process of meaning-making--and as such, they do not lie in the waiting for telling, but are an active part of everyday interaction. Telling stories about ourselves to others is one way in which…

Goals for Business Operations and Family Life. The Manufacturer's Tool Kit and Instructor's Guide. North Central Regional Extension Publications #286 and #288.

ERIC Educational Resources Information Center

Gessaman, Paul H.

This packet contains student materials and an instructor's guide for use in a series of workshops on the "GOALS Process" for persons in manufacturing businesses (often family-owned). The materials provide a framework for individual or family use in self-assessment and a means of identifying business and family life goals, setting priorities, and…

Goals for Business Operations and Family Life. The Service Provider's Tool Kit and Instructor's Guide. North Central Regional Extension Publications #287 and #288.

ERIC Educational Resources Information Center

Gessaman, Paul H.

This packet contains student materials and an instructor's guide for use in a series of workshops on the "GOALS Process" for persons in service-producing businesses (often family-owned). The materials provide a framework for individual or family use in self-assessment and a means of identifying business and family life goals, setting priorities,…

ONR (Office of Naval Research) Far East Scientific Information Bulletin. Volume 14, Number 1, January-March 1989

DTIC Science & Technology

1989-03-01

central meanings, traced in the Western classics and Indo-European for subsequent etymological development, comparative linguistics, Dr. Thieme has and...properties at reasonable costs. diamond films, processing conditions for Diamond for industrial applications the fabrication of diamond films, applica- is... applications such as diamondlike films, are beginning to reach heat sinks will also become economically the industrial marketplace. The precise feasible

A public health initiative for reducing access to pesticides as a means to committing suicide: findings from a qualitative study.

PubMed

Mohanraj, Rani; Kumar, Shuba; Manikandan, Sarojini; Kannaiyan, Veerapandian; Vijayakumar, Lakshmi

2014-08-01

Widespread use of pesticides among farmers in rural India, provides an easy means for suicide. A public health initiative involving storage of pesticides in a central storage facility could be a possible strategy for reducing mortality and morbidity related to pesticide poisoning. This qualitative study explored community perceptions towards a central pesticide storage facility in villages in rural South India. Sixteen focus group discussions held with consenting adults from intervention and control villages were followed by eight more a year after initiation of the storage facility. Analysis revealed four themes, namely, reasons for committing suicide and methods used, exposure to pesticides and first-aid practices, storage and disposal of pesticides, and perceptions towards the storage facility. The facility was appreciated as a means of preventing suicides and for providing a safe haven for pesticide storage. The participatory process that guided its design, construction and location ensured its acceptability. Use of qualitative methods helped provide deep insights into the phenomenon of pesticide suicide and aided the understanding of community perceptions towards the storage facility. The study suggests that communal storage of pesticides could be an important step towards reducing pesticide suicides in rural areas.

Genetic Diversity in Nothofagus alessandrii (Fagaceae), an Endangered Endemic Tree Species of the Coastal Maulino Forest of Central Chile

PubMed Central

Torres-Díaz, Cristian; Ruiz, Eduardo; González, Fidelina; Fuentes, Glenda; Cavieres, Lohengrin A.

2007-01-01

Background and Aims The endemic tree Nothofagus alessandrii (Fagaceae) has been historically restricted to the coastal range of Region VII of central Chile, and its forests have been increasingly destroyed and fragmented since the end of the 19th century. In this study, the patterns of within- and among-population genetic diversity in seven fragments of this endangered narrowly endemic tree were examined. Methods Allozyme electrophoresis of seven loci of N. alessandrii was used to estimate genetic diversity, genetic structure and gene flow. Key Results High levels of genetic diversity were found as shown by mean expected heterozygosity (He = 0·182 ± 0·034), percentage of polymorphic loci (Pp = 61·2 %), mean number of alleles per locus (A = 1·8) and mean number of alleles per polymorphic locus (Ap = 2·3). Genetic differentiation was also high (GST = 0·257 and Nm = 0·7). These values are high compared with more widespread congeneric species. Conclusions Despite its endemic status and restricted geographical range N. alessandrii showed high levels of genetic diversity. The observed patterns of diversity are explained in part by historical processes and more recent human fragmentation. PMID:17513870

Artificial neural network modelling of a large-scale wastewater treatment plant operation.

PubMed

Güçlü, Dünyamin; Dursun, Sükrü

2010-11-01

Artificial Neural Networks (ANNs), a method of artificial intelligence method, provide effective predictive models for complex processes. Three independent ANN models trained with back-propagation algorithm were developed to predict effluent chemical oxygen demand (COD), suspended solids (SS) and aeration tank mixed liquor suspended solids (MLSS) concentrations of the Ankara central wastewater treatment plant. The appropriate architecture of ANN models was determined through several steps of training and testing of the models. ANN models yielded satisfactory predictions. Results of the root mean square error, mean absolute error and mean absolute percentage error were 3.23, 2.41 mg/L and 5.03% for COD; 1.59, 1.21 mg/L and 17.10% for SS; 52.51, 44.91 mg/L and 3.77% for MLSS, respectively, indicating that the developed model could be efficiently used. The results overall also confirm that ANN modelling approach may have a great implementation potential for simulation, precise performance prediction and process control of wastewater treatment plants.

Effects of artificial tear treatment on corneal epithelial thickness and corneal topography findings in dry eye patients.

PubMed

Çakır, B; Doğan, E; Çelik, E; Babashli, T; Uçak, T; Alagöz, G

2018-05-01

To investigate the effects of artificial tear treatment on central corneal epithelial thickness, and central, mid-peripheral and peripheral corneal thicknesses in patients with dry eye disease (DED). Patients with DED underwent ocular examinations, including Schirmer-2 test, slit lamp examination for tear break-up time (BUT), corneal topography (CT) for measuring mean central, mid-peripheral and peripheral corneal thickness values and anterior segment optic coherence tomography (AS-OCT) for obtaining central corneal epithelial thickness. After artificial tear treatment (carboxymethylcellulose and sodium hyaluronate formulations) for one month, patients were examined again at a second visit and the results were compared. Sixty-one eyes of 33 female dry eye patients (mean age: 38.3±5.7 years) were enrolled. The mean follow-up time was 36.4±3.3 days. The mean tear BUT and Schirmer-1 tests revealed significant improvement after treatment (P=0.000, P=0.000, respectively). Central corneal epithelium and mean mid-peripheral corneal thicknesses measured significantly higher after treatment (P=0.001, P=0.02). Changes in central and peripheral corneal thicknesses were not statistically significant. Artificial tear treatment in dry eye patients seems to increase central corneal epithelial and mid-peripheral corneal thicknesses. Measurement of corneal epithelial thickness can be a useful tool for evaluation of treatment response in dry eye patients. Further long-term prospective studies are needed to investigate this item. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

[Influence of Spectral Pre-Processing on PLS Quantitative Model of Detecting Cu in Navel Orange by LIBS].

PubMed

Li, Wen-bing; Yao, Lin-tao; Liu, Mu-hua; Huang, Lin; Yao, Ming-yin; Chen, Tian-bing; He, Xiu-wen; Yang, Ping; Hu, Hui-qin; Nie, Jiang-hui

2015-05-01

Cu in navel orange was detected rapidly by laser-induced breakdown spectroscopy (LIBS) combined with partial least squares (PLS) for quantitative analysis, then the effect on the detection accuracy of the model with different spectral data ptetreatment methods was explored. Spectral data for the 52 Gannan navel orange samples were pretreated by different data smoothing, mean centralized and standard normal variable transform. Then 319~338 nm wavelength section containing characteristic spectral lines of Cu was selected to build PLS models, the main evaluation indexes of models such as regression coefficient (r), root mean square error of cross validation (RMSECV) and the root mean square error of prediction (RMSEP) were compared and analyzed. Three indicators of PLS model after 13 points smoothing and processing of the mean center were found reaching 0. 992 8, 3. 43 and 3. 4 respectively, the average relative error of prediction model is only 5. 55%, and in one word, the quality of calibration and prediction of this model are the best results. The results show that selecting the appropriate data pre-processing method, the prediction accuracy of PLS quantitative model of fruits and vegetables detected by LIBS can be improved effectively, providing a new method for fast and accurate detection of fruits and vegetables by LIBS.

Climatic niche conservatism and biogeographical non-equilibrium in Eschscholzia californica (Papaveraceae), an invasive plant in the Chilean Mediterranean region.

PubMed

Peña-Gómez, Francisco T; Guerrero, Pablo C; Bizama, Gustavo; Duarte, Milén; Bustamante, Ramiro O

2014-01-01

Species climate requirements are useful for predicting their geographic distribution. It is often assumed that the niche requirements for invasive plants are conserved during invasion, especially when the invaded regions share similar climate conditions. California and central Chile have a remarkable degree of convergence in their vegetation structure, and a similar Mediterranean climate. Such similarities make these geographic areas an interesting natural experiment for testing climatic niche dynamics and the equilibrium of invasive species in a new environment. We tested to see if the climatic niche of Eschscholzia californica is conserved in the invaded range (central Chile), and we assessed whether the invasion process has reached a biogeographical equilibrium, i.e., occupy all the suitable geographic locations that have suitable conditions under native niche requirements. We compared the climatic niche in the native and invaded ranges as well as the projected potential geographic distribution in the invaded range. In order to compare climatic niches, we conducted a Principal Component Analysis (PCA) and Species Distribution Models (SDMs), to estimate E. californica's potential geographic distribution. We also used SDMs to predict altitudinal distribution limits in central Chile. Our results indicated that the climatic niche occupied by E. californica in the invaded range is firmly conserved, occupying a subset of the native climatic niche but leaving a substantial fraction of it unfilled. Comparisons of projected SDMs for central Chile indicate a similarity, yet the projection from native range predicted a larger geographic distribution in central Chile compared to the prediction of the model constructed for central Chile. The projected niche occupancy profile from California predicted a higher mean elevation than that projected from central Chile. We concluded that the invasion process of E. californica in central Chile is consistent with climatic niche conservatism but there is potential for further expansion in Chile.

48 CFR 252.225-7036 - Buy American-Free Trade Agreements-Balance of Payments Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the basic clause: (a) “South Caucasus/Central and South Asian (SC/CASA) state” means Armenia... Caucasus/Central and South Asian (SC/CASA) state end product” means an article that— (i) Is wholly the... South Asian (SC/CASA) state means Armenia, Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan, Pakistan...

48 CFR 252.225-7036 - Buy American-Free Trade Agreements-Balance of Payments Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the basic clause: (a) South Caucasus/Central and South Asian (SC/CASA) state means Armenia, Azerbaijan... and South Asian (SC/CASA) state end product means an article that— (i) Is wholly the growth, product... Caucasus/Central and South Asian (SC/CASA) state means Armenia, Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan...

48 CFR 252.225-7036 - Buy American-Free Trade Agreements-Balance of Payments Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the basic clause: (a) “South Caucasus/Central and South Asian (SC/CASA) state” means Armenia... Caucasus/Central and South Asian (SC/CASA) state end product” means an article that— (i) Is wholly the... South Asian (SC/CASA) state means Armenia, Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan, Pakistan...

ERP evidence for memory and predictive mechanisms in word-to-text integration

PubMed Central

Stafura, Joseph Z.; Rickles, Benjamin; Perfetti, Charles A.

2016-01-01

During reading, word-to-text integration processes proceed quickly and incrementally through both prospective (predictive) and retrospective (memory) processes. Across a sentence boundary, where prediction may be less functional, memorial processes may be especially important. We tested predictive and memory mechanisms with event-related potentials (ERPs) recorded on the first content word across a sentence boundary by manipulating the direction of association between this word and one from the preceding sentence. For comparison with this text comprehension (TC) task, we tested these same word pairs in a word meaning judgment (MJ) task. In both tasks we found reduced N400 amplitudes over central scalp electrodes when the two words were either forward-associated (FA) or backward-associated (BA), relative to task-specific baseline conditions. In the MJ task, FA pairs produced a greater reduction in the N400 reduction than BA pairs over right parietal areas. However, in the TC task, BA pairs produced a greater N400 reduction than FA pairs over left parietal electrodes. A temporal principal component analysis of TC and MJ data showed a component reflecting the central N400. Additional components from TC data reflected FA-BA differences during early (N200) and late (parietal N400 and LPC) phases of processing. Comprehension skill predicted association effects in the MJ task, especially FA, and the BA central N400 effects in the TC task. The results demonstrate that, beyond N400 indicators of prediction effects, ERPs reflect the role of memory processes in word-to-text integration across sentences, part of a dynamic interplay between anticipatory and memorial processes that support comprehension. PMID:27110578

32 CFR 1907.02 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CHALLENGES TO... means the United States Central Intelligence Agency acting through the CIA Information and Privacy... Agency Release Panel; (g) Information means any knowledge that can be communicated or documentary...

32 CFR 1907.02 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CHALLENGES TO... means the United States Central Intelligence Agency acting through the CIA Information and Privacy... Agency Release Panel; (g) Information means any knowledge that can be communicated or documentary...

32 CFR 1907.02 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CHALLENGES TO... means the United States Central Intelligence Agency acting through the CIA Information and Privacy... Agency Release Panel; (g) Information means any knowledge that can be communicated or documentary...

Variable frequency microprocessor clock generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Branson, C.N.

A microprocessor-based system is described comprising: a digital central microprocessor provided with a clock input and having a rate of operation determined by the frequency of a clock signal input thereto; memory means operably coupled to the central microprocessor for storing programs respectively including a plurality of instructions and addressable by the central microprocessor; peripheral device operably connected to the central microprocessor, the first peripheral device being addressable by the central microprocessor for control thereby; a system clock generator for generating a digital reference clock signal having a reference frequency rate; and frequency rate reduction circuit means connected between themore » clock generator and the clock input of the central microprocessor for selectively dividing the reference clock signal to generate a microprocessor clock signal as an input to the central microprocessor for clocking the central microprocessor.« less

Mean-Eddy-Turbulence Interaction through Canonical Transfer Analysis: Theory and Application to the Kuroshio Extension Energetics Study

NASA Astrophysics Data System (ADS)

Liang, X. S.

2016-02-01

Central at the processes of mean-eddy-turbulence interaction, e.g., mesoscale eddy shedding, relaminarization, etc., is the transfer of energy among different scales. The existing classical transfers, however, do not take into account the issue of energy conservation and, therefore, are not faithful representations of the real interaction processes, which are fundamentally a redistribution of energy among scales. Based on a new analysis machinery, namely, multiscale window transform (Liang and Anderson, 2007), we were able to obtain a formula for this important processes, with the property of energy conservation a naturally embedded property. This formula has a form reminiscent of the Poisson bracket in Hamiltonian dynamics. It has been validated with many benchmark processes, and, particularly, has been applied with success to control the eddy shedding behind a bluff body. Presented here will be an application study of the instabilities and mean-eddy interactions in the Kuroshio Extension (KE) region. Generally, it is found that the unstable KE jet fuels the mesoscale eddies, but in the offshore eddy decaying region, the cause-effect relation reverses: it is the latter that drive the former. On the whole the eddies act to decelerate the jet in the upstream, whereas accelerating it downstream.

Changing to Concept-Based Curricula: The Process for Nurse Educators

PubMed Central

Baron, Kristy A.

2017-01-01

Background: The complexity of health care today requires nursing graduates to use effective thinking skills. Many nursing programs are revising curricula to include concept-based learning that encourages problem-solving, effective thinking, and the ability to transfer knowledge to a variety of situations—requiring nurse educators to modify their teaching styles and methods to promote student-centered learning. Changing from teacher-centered learning to student-centered learning requires a major shift in thinking and application. Objective: The focus of this qualitative study was to understand the process of changing to concept-based curricula for nurse educators who previously taught in traditional curriculum designs. Methods: The sample included eight educators from two institutions in one Western state using a grounded theory design. Results: The themes that emerged from participants’ experiences consisted of the overarching concept, support for change, and central concept, finding meaning in the change. Finding meaning is supported by three main themes: preparing for the change, teaching in a concept-based curriculum, and understanding the teaching-learning process. Conclusion: Changing to a concept-based curriculum required a major shift in thinking and application. Through support, educators discovered meaning to make the change by constructing authentic learning opportunities that mirrored practice, refining the change process, and reinforcing benefits of teaching. PMID:29399236

Defining and Enforcing Hardware Security Requirements

DTIC Science & Technology

2011-12-01

Computer-Aided Design CPU Central Processing Unit CTL Computation Tree Logic DARPA The Defense Advanced Projects Research Agency DFF D-type Flip-Flop DNF...They too have no global knowledge of what is going on, nor any meaning to attach to any bit, whether storage or gating . . . it is we who attach...This option is prohibitively ex- pensive with the current trends in the global distribution of the steps in IC design and fabrication. The second option

Real-time simulation clock

NASA Technical Reports Server (NTRS)

Bennington, Donald R. (Inventor); Crawford, Daniel J. (Inventor)

1990-01-01

The invention is a clock for synchronizing operations within a high-speed, distributed data processing network. The clock is actually a distributed system comprising a central clock and multiple site clock interface units (SCIUs) which are connected by means of a fiber optic star network and which operate under control of separate clock software. The presently preferred embodiment is a part of the flight simulation system now in current use at the NASA Langley Research Center.

Creative pricing strategies for medical services.

PubMed

Tellis, G J

1987-01-01

This paper discusses the strategic role of the pricing of medical services. Strategic pricing is a creative process that can be a vital means of defining marketing segments, differentiating services, and gaining a competitive advantage. The central issue in strategic pricing is creatively using the principle of cross-subsidies or shared economies over consumer groups, service sets, or competitors. This principle yields a rich set of pricing strategies that can be used in response to various environments.

Deviations from a uniform period spacing of gravity modes in a massive star.

PubMed

Degroote, Pieter; Aerts, Conny; Baglin, Annie; Miglio, Andrea; Briquet, Maryline; Noels, Arlette; Niemczura, Ewa; Montalban, Josefina; Bloemen, Steven; Oreiro, Raquel; Vucković, Maja; Smolders, Kristof; Auvergne, Michel; Baudin, Frederic; Catala, Claude; Michel, Eric

2010-03-11

The life of a star is dominantly determined by the physical processes in the stellar interior. Unfortunately, we still have a poor understanding of how the stellar gas mixes near the stellar core, preventing precise predictions of stellar evolution. The unknown nature of the mixing processes as well as the extent of the central mixed region is particularly problematic for massive stars. Oscillations in stars with masses a few times that of the Sun offer a unique opportunity to disentangle the nature of various mixing processes, through the distinct signature they leave on period spacings in the gravity mode spectrum. Here we report the detection of numerous gravity modes in a young star with a mass of about seven solar masses. The mean period spacing allows us to estimate the extent of the convective core, and the clear periodic deviation from the mean constrains the location of the chemical transition zone to be at about 10 per cent of the radius and rules out a clear-cut profile.

Positive experiences for participants in suicide bereavement groups: a grounded theory model.

PubMed

Groos, Anita D; Shakespeare-Finch, Jane

2013-01-01

Grounded Theory was used to examine the experiences of 13 participants who had attended psycho-educational support groups for those bereaved by suicide. Results demonstrated core and central categories that fit well with group therapeutic factors developed by I. D. Yalom (1995) and emphasized the importance of universality, imparting information and instilling hope, catharsis and self-disclosure, and broader meaning-making processes surrounding acceptance or adjustment. Participants were commonly engaged in a lengthy process of oscillating between loss-oriented and restoration-focused reappraisals. The functional experience of the group comprised feeling normal within the group, providing a sense of permission to feel and to express emotions and thoughts and to bestow meaning. Structural variables of information and guidance and different perspectives on the suicide and bereavement were gained from other participants, the facilitators, group content, and process. Personal changes, including in relationships and in their sense of self assisted participants to develop an altered and more positive personal narrative.

Relevance theory: pragmatics and cognition.

PubMed

Wearing, Catherine J

2015-01-01

Relevance Theory is a cognitively oriented theory of pragmatics, i.e., a theory of language use. It builds on the seminal work of H.P. Grice(1) to develop a pragmatic theory which is at once philosophically sensitive and empirically plausible (in both psychological and evolutionary terms). This entry reviews the central commitments and chief contributions of Relevance Theory, including its Gricean commitment to the centrality of intention-reading and inference in communication; the cognitively grounded notion of relevance which provides the mechanism for explaining pragmatic interpretation as an intention-driven, inferential process; and several key applications of the theory (lexical pragmatics, metaphor and irony, procedural meaning). Relevance Theory is an important contribution to our understanding of the pragmatics of communication. © 2014 John Wiley & Sons, Ltd.

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

Individuals with traumatic brain injuries perceptions and experiences of returning to work in South Africa.

PubMed

Soeker, Mogammad Shaheed; Van Rensburg, Viki; Travill, Andre

2012-01-01

The aim of this study was to identify the central concepts of a model that would facilitate the return to work process of individuals with brain injury. However for the purpose of this paper there will be a focus only on the barriers and facilitators that influence the return to work process. Ten individuals who were diagnosed with a mild to moderate brain injury participated in this study. Qualitative research methods were used in order to explore the research question. The participants were selected by means of purposive sampling and the data was collected by means of in depth interviews. The results of the study revealed that the participants experienced a sense of loss of function after the brain injury, a fear of the future and loss of confidence in their worker roles. The participants also indicated that by means of adapting occupational routines an actively engaging in rehabilitation they developed confidence in their worker roles. Occupational therapists have to use a client centred holistic work integrative approach in order to successfully rehabilitate as well as facilitate the return to work process with people who have suffered a traumatic brain injury.

Early Cognitive Outcomes Following Proton Radiation in Pediatric Patients With Brain and Central Nervous System Tumors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pulsifer, Margaret B., E-mail: mpulsifer@mgh.harvard.edu; Sethi, Roshan V.; Kuhlthau, Karen A.

Purpose: To report, from a longitudinal study, cognitive outcome in pediatric patients treated with proton radiation therapy (PRT) for central nervous system (CNS) tumors. Methods and Materials: Sixty patients receiving PRT for medulloblastoma (38.3%), gliomas (18.3%), craniopharyngioma (15.0%), ependymoma (11.7%), and other CNS tumors (16.7%) were administered age-appropriate measures of cognitive abilities at or near PRT initiation (baseline) and afterward (follow-up). Patients were aged ≥6 years at baseline to ensure consistency in neurocognitive measures. Results: Mean age was 12.3 years at baseline; mean follow-up interval was 2.5 years. Treatment included prior surgical resection (76.7%) and chemotherapy (61.7%). Proton radiation therapy included craniospinal irradiationmore » (46.7%) and partial brain radiation (53.3%). At baseline, mean Wechsler Full Scale IQ was 104.6; means of all 4 Index scores were also in the average range. At follow-up, no significant change was observed in mean Wechsler Full Scale IQ, Verbal Comprehension, Perceptual Reasoning/Organization, or Working Memory. However, Processing Speed scores declined significantly (mean 5.2 points), with a significantly greater decline for subjects aged <12 years at baseline and those with the highest baseline scores. Cognitive outcome was not significantly related to gender, extent of radiation, radiation dose, tumor location, histology, socioeconomic status, chemotherapy, or history of surgical resection. Conclusions: Early cognitive outcomes after PRT for pediatric CNS tumors are encouraging, compared with published outcomes from photon radiation therapy.« less

The influence of (central) auditory processing disorder on the severity of speech-sound disorders in children.

PubMed

Vilela, Nadia; Barrozo, Tatiane Faria; Pagan-Neves, Luciana de Oliveira; Sanches, Seisse Gabriela Gandolfi; Wertzner, Haydée Fiszbein; Carvallo, Renata Mota Mamede

2016-02-01

To identify a cutoff value based on the Percentage of Consonants Correct-Revised index that could indicate the likelihood of a child with a speech-sound disorder also having a (central) auditory processing disorder . Language, audiological and (central) auditory processing evaluations were administered. The participants were 27 subjects with speech-sound disorders aged 7 to 10 years and 11 months who were divided into two different groups according to their (central) auditory processing evaluation results. When a (central) auditory processing disorder was present in association with a speech disorder, the children tended to have lower scores on phonological assessments. A greater severity of speech disorder was related to a greater probability of the child having a (central) auditory processing disorder. The use of a cutoff value for the Percentage of Consonants Correct-Revised index successfully distinguished between children with and without a (central) auditory processing disorder. The severity of speech-sound disorder in children was influenced by the presence of (central) auditory processing disorder. The attempt to identify a cutoff value based on a severity index was successful.

[Initial epidemiological data on the clinical effects in health workers employed in the manual lifting of patients in wards].

PubMed

Colombini, D; Riva, F; Luè, D; Nava, C; Petri, A; Basilico, S; Linzalata, M; Morselli, G; Cotroneo, L; Ricci, M G; Menoni, O; Battevi, N

1999-01-01

An investigation was carried out by teams from various centres coordinated by the EPM (Ergonomics of Posture and Movement) Research Unit on 54 different hospitals in various regions of northern and central Italy. The teams examined a total of 3341 health workers whose job involved manual handling of patients (553 male and 2788 females, 1568 working in hospitals and 1773 in geriatric residences). Numerous meetings were held to ensure that the methods of assessing the exposure indexes and spinal impairment were identical in the various teams. The final data were processed centrally at the EPM Research Unit. The sample analyzed may be considered as representative of the situation in hospitals in Italy, at least for northern and central Italy. The mean age was 36 years, mean length of service in the department 6 years and mean length of job duration not exceeding 10 years; staff turnover was high. Physical examination revealed that 8.4% of the workers had had at least one episode of acute low back pain in the previous 12 months: i.e., 4 times the values of the reference groups. Also in the case of clinical-functional spondyloarthropathies of the lumbosacral spine, in the females there was a significantly higher prevalence than in the reference groups. All disorders were more severe in sectors more at risk, i.e., old peoples homes, rehabilitation centres, orthopaedic and surgical departments, and in any case higher in old peoples homes and geriatric residences. The initial data concerning the ratio between presence of spinal disease and risk index were also positive.

How does language change as a lexical network? An investigation based on written Chinese word co-occurrence networks

PubMed Central

Chen, Heng; Chen, Xinying

2018-01-01

Language is a complex adaptive system, but how does it change? For investigating this process, four diachronic Chinese word co-occurrence networks have been built based on texts that were written during the last 2,000 years. By comparing the network indicators that are associated with the hierarchical features in language networks, we learn that the hierarchy of Chinese lexical networks has indeed evolved over time at three different levels. The connections of words at the micro level are continually weakening; the number of words in the meso-level communities has increased significantly; and the network is expanding at the macro level. This means that more and more words tend to be connected to medium-central words and form different communities. Meanwhile, fewer high-central words link these communities into a highly efficient small-world network. Understanding this process may be crucial for understanding the increasing structural complexity of the language system. PMID:29489837

How does language change as a lexical network? An investigation based on written Chinese word co-occurrence networks.

PubMed

Chen, Heng; Chen, Xinying; Liu, Haitao

2018-01-01

Language is a complex adaptive system, but how does it change? For investigating this process, four diachronic Chinese word co-occurrence networks have been built based on texts that were written during the last 2,000 years. By comparing the network indicators that are associated with the hierarchical features in language networks, we learn that the hierarchy of Chinese lexical networks has indeed evolved over time at three different levels. The connections of words at the micro level are continually weakening; the number of words in the meso-level communities has increased significantly; and the network is expanding at the macro level. This means that more and more words tend to be connected to medium-central words and form different communities. Meanwhile, fewer high-central words link these communities into a highly efficient small-world network. Understanding this process may be crucial for understanding the increasing structural complexity of the language system.

Experiences from Pagan Women: A Closer Look at Croning Rituals

PubMed Central

Manning, Lydia K.

2012-01-01

In this qualitative study I explore how Pagan women conceptualize aging, more specifically social aging, through the ritual process of being a Pagan and becoming a Crone. The central question of this research revolves around how older women who identify as Pagan experience, understand, and conceptualize their social aging and their role as aging women in American society. Semi-structured interviews were used to collect data and explore the meaning of aging for women identifying as Pagan. Major emergent themes within the data demonstrate that the croning ritual, a central aspect of Paganism, affirms these women in their process of aging. These women, through the ritual of croning, are able to understand their aging as celebration, maintain a positive sense of self while aging, and reclaim visibility as aging women. These women were able to embed their experiences of aging within a unique and specific cultural framework, a spiritual and foundational framework cultivating a spiritual connection with nature. PMID:23559691

49 CFR 239.7 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the Administrator's delegate. Control center means a central location on a railroad with....g., a superintendent, division manager, or equivalent), who has jurisdiction over a portion of the... passenger train emergency. Emergency response communications center means a central location, or a group of...

On some labelings of triangular snake and central graph of triangular snake graph

NASA Astrophysics Data System (ADS)

Agasthi, P.; Parvathi, N.

2018-04-01

A Triangular snake Tn is obtained from a path u 1 u 2 … u n by joining ui and u i+1 to a new vertex wi for 1≤i≤n‑1. A Central graph of Triangular snake C(T n ) is obtained by subdividing each edge of Tn exactly once and joining all the non adjacent vertices of Tn . In this paper the ways to construct square sum, square difference, Root Mean square, strongly Multiplicative, Even Mean and Odd Mean labeling for Triangular Snake and Central graph of Triangular Snake graphs are reported.

Comprehending expository texts: the dynamic neurobiological correlates of building a coherent text representation

PubMed Central

Swett, Katherine; Miller, Amanda C.; Burns, Scott; Hoeft, Fumiko; Davis, Nicole; Petrill, Stephen A.; Cutting, Laurie E.

2013-01-01

Little is known about the neural correlates of expository text comprehension. In this study, we sought to identify neural networks underlying expository text comprehension, how those networks change over the course of comprehension, and whether information central to the overall meaning of the text is functionally distinct from peripheral information. Seventeen adult subjects read expository passages while being scanned using functional magnetic resonance imaging (fMRI). By convolving phrase onsets with the hemodynamic response function (HRF), we were able to identify regions that increase and decrease in activation over the course of passage comprehension. We found that expository text comprehension relies on the co-activation of the semantic control network and regions in the posterior midline previously associated with mental model updating and integration [posterior cingulate cortex (PCC) and precuneus (PCU)]. When compared to single word comprehension, left PCC and left Angular Gyrus (AG) were activated only for discourse-level comprehension. Over the course of comprehension, reliance on the same regions in the semantic control network increased, while a parietal region associated with attention [intraparietal sulcus (IPS)] decreased. These results parallel previous findings in narrative comprehension that the initial stages of mental model building require greater visuospatial attention processes, while maintenance of the model increasingly relies on semantic integration regions. Additionally, we used an event-related analysis to examine phrases central to the text's overall meaning vs. peripheral phrases. It was found that central ideas are functionally distinct from peripheral ideas, showing greater activation in the PCC and PCU, while over the course of passage comprehension, central and peripheral ideas increasingly recruit different parts of the semantic control network. The finding that central information elicits greater response in mental model updating regions than peripheral ideas supports previous behavioral models on the cognitive importance of distinguishing textual centrality. PMID:24376411

The posterior cruciate ligament: a study on its bony and soft tissue anatomy using novel 3D CT technology.

PubMed

Van Hoof, Tom; Cromheecke, Michiel; Tampere, Thomas; D'herde, Katharina; Victor, Jan; Verdonk, Peter C M

2013-05-01

The bony insertion sites of the PCL have been studied and described extensively using 2D technology such as macroscopic images, plain radiograph, computerized tomography (CT) and MRI. The purpose of this study is to visualize both the tibial and the femoral bony insertion sites but also the soft tissue anatomy of the native PCL using novel 3D CT imaging. In addition, new concepts of best-fit cylinder and central axis are introduced and evaluated. Nine unpaired knees of embalmed cadavers were used in this study. Following the dissection process, the PCL was injected with a contrast medium for computed tomography (CT) imaging. The obtained CT images were segmented and rendered in 3D allowing morphological and morphometric analysis of PCL. Femoral and tibial footprint surface area, best-fit PCL-cylinder intersection area, best-fit PCL-cylinder/footprint coverage ratio, best-fit PCL-cylinder central axis projections at the tibial and femoral footprint were used to describe the anatomy of the PCL. Mean footprint surface area of the tibial and femoral footprint were 189.1 and 293.3 mm², respectively. The mean diameter of the best-fit cylinder was 10.5 mm. The mean coverage of the best-fit cylinder on the tibial and femoral footprint was 76.5 and 46.5, respectively. The best-fit cylinder central axis was located in the anterolateral AL bundle footprint on the femur and more centrally in the PCL footprint on the tibia. This study is the first to describe the detailed anatomy of the human PCL with respect to its course and footprints using a 3D approach. It confirms the large difference between the tibial and the femoral footprint area with the former being significantly smaller. In addition, a large inter-patient variability is observed. The best-fit cylinder and central axis concept offer additional insights into the optimal tunnel placement at the tibia and femoral footprint in order to cover the largest portion of the native PCL soft tissue.

Textpresso Central: a customizable platform for searching, text mining, viewing, and curating biomedical literature.

PubMed

Müller, H-M; Van Auken, K M; Li, Y; Sternberg, P W

2018-03-09

The biomedical literature continues to grow at a rapid pace, making the challenge of knowledge retrieval and extraction ever greater. Tools that provide a means to search and mine the full text of literature thus represent an important way by which the efficiency of these processes can be improved. We describe the next generation of the Textpresso information retrieval system, Textpresso Central (TPC). TPC builds on the strengths of the original system by expanding the full text corpus to include the PubMed Central Open Access Subset (PMC OA), as well as the WormBase C. elegans bibliography. In addition, TPC allows users to create a customized corpus by uploading and processing documents of their choosing. TPC is UIMA compliant, to facilitate compatibility with external processing modules, and takes advantage of Lucene indexing and search technology for efficient handling of millions of full text documents. Like Textpresso, TPC searches can be performed using keywords and/or categories (semantically related groups of terms), but to provide better context for interpreting and validating queries, search results may now be viewed as highlighted passages in the context of full text. To facilitate biocuration efforts, TPC also allows users to select text spans from the full text and annotate them, create customized curation forms for any data type, and send resulting annotations to external curation databases. As an example of such a curation form, we describe integration of TPC with the Noctua curation tool developed by the Gene Ontology (GO) Consortium. Textpresso Central is an online literature search and curation platform that enables biocurators and biomedical researchers to search and mine the full text of literature by integrating keyword and category searches with viewing search results in the context of the full text. It also allows users to create customized curation interfaces, use those interfaces to make annotations linked to supporting evidence statements, and then send those annotations to any database in the world. Textpresso Central URL: http://www.textpresso.org/tpc.

Processing of prosodic changes in natural speech stimuli in school-age children.

PubMed

Lindström, R; Lepistö, T; Makkonen, T; Kujala, T

2012-12-01

Speech prosody conveys information about important aspects of communication: the meaning of the sentence and the emotional state or intention of the speaker. The present study addressed processing of emotional prosodic changes in natural speech stimuli in school-age children (mean age 10 years) by recording the electroencephalogram, facial electromyography, and behavioral responses. The stimulus was a semantically neutral Finnish word uttered with four different emotional connotations: neutral, commanding, sad, and scornful. In the behavioral sound-discrimination task the reaction times were fastest for the commanding stimulus and longest for the scornful stimulus, and faster for the neutral than for the sad stimulus. EEG and EMG responses were measured during non-attentive oddball paradigm. Prosodic changes elicited a negative-going, fronto-centrally distributed neural response peaking at about 500 ms from the onset of the stimulus, followed by a fronto-central positive deflection, peaking at about 740 ms. For the commanding stimulus also a rapid negative deflection peaking at about 290 ms from stimulus onset was elicited. No reliable stimulus type specific rapid facial reactions were found. The results show that prosodic changes in natural speech stimuli activate pre-attentive neural change-detection mechanisms in school-age children. However, the results do not support the suggestion of automaticity of emotion specific facial muscle responses to non-attended emotional speech stimuli in children. Copyright © 2012 Elsevier B.V. All rights reserved.

Climate Change Impacts on Sediment Transport In a Lowland Watershed System: Controlling Processes and Projection

NASA Astrophysics Data System (ADS)

al Aamery, N. M. H.; Mahoney, D. T.; Fox, J.

2017-12-01

Future climate change projections suggest extreme impacts on watershed hydrologic systems for some regions of the world including pronounced increases in surface runoff and instream flows. Yet, there remains a lack of research focused on how future changes in hydrologic extremes, as well as relative hydrologic mean changes, impact sediment redistribution within a watershed and sediment flux from a watershed. The authors hypothesized that variations in mean and extreme changes in turn may impact sediments in depositional and erosional dominance in a manner that may not be obvious to the watershed manager. Therefore, the objectives of this study were to investigate the inner processes connecting the combined effect of extreme climate change projections on the vegetation, upland erosion, and instream processes to produce changes in sediment redistribution within watersheds. To do so, research methods were carried out by the authors including simulating sediment processes in forecast and hindcast periods for a lowland watershed system. Publically available climate realizations from several climate factors and the Soil Water Assessment Tool (SWAT) were used to predict hydrologic conditions for the South Elkhorn Watershed in central Kentucky, USA to 2050. The results of the simulated extreme and mean hydrological components were used in simulating upland erosion with the connectivity processes consideration and thereafter used in building and simulating the instream erosion and deposition of sediment processes with the consideration of surface fine grain lamina (SFGL) layer controlling the benthic ecosystem. Results are used to suggest the dominance of erosional and depositional redistribution of sediments under different scenarios associated with extreme and mean hydrologic forecasting. The results are discussed in reference to the benthic ecology of the stream system providing insight on how water managers might consider sediment redistribution in a changing climate.

Central gender theoretical concepts in health research: the state of the art.

PubMed

Hammarström, Anne; Johansson, Klara; Annandale, Ellen; Ahlgren, Christina; Aléx, Lena; Christianson, Monica; Elwér, Sofia; Eriksson, Carola; Fjellman-Wiklund, Anncristine; Gilenstam, Kajsa; Gustafsson, Per E; Harryson, Lisa; Lehti, Arja; Stenberg, Gunilla; Verdonk, Petra

2014-02-01

Despite increasing awareness of the importance of gender perspectives in health science, there is conceptual confusion regarding the meaning and the use of central gender theoretical concepts. We argue that it is essential to clarify how central concepts are used within gender theory and how to apply them to health research. We identify six gender theoretical concepts as central and interlinked-but problematic and ambiguous in health science: sex, gender, intersectionality, embodiment, gender equity and gender equality. Our recommendations are that: the concepts sex and gender can benefit from a gender relational theoretical approach (i.e., a focus on social processes and structures) but with additional attention to the interrelations between sex and gender; intersectionality should go beyond additive analyses to study complex intersections between the major factors which potentially influence health and ensure that gendered power relations and social context are included; we need to be aware of the various meanings given to embodiment, which achieve an integration of gender and health and attend to different levels of analyses to varying degrees; and appreciate that gender equality concerns absence of discrimination between women and men while gender equity focuses on women's and men's health needs, whether similar or different. We conclude that there is a constant need to justify and clarify our use of these concepts in order to advance gender theoretical development. Our analysis is an invitation for dialogue but also a call to make more effective use of the knowledge base which has already developed among gender theorists in health sciences in the manner proposed in this paper.

The Toxicity of Inhaled Sulphur Mustard

DTIC Science & Technology

2012-03-01

Pulse oximetry Mean arterial pressure Central venous pressure Blood Chemistry (arterial and venous ) pH pO2 pCO2 Sodium Potassium Calcium...Cardiovascular Parameters − CFI – Cardiac Function Index − CO – Cardiac Output − CvO2 – Mixed Venous Oxygenation − CVP – Central Venous Pressure...Data are expressed as mean ± SEM. Changes in central venous pressure following exposure to HD: HD controls () and HD + NAC (). Data are

Is the Motor System Necessary for Processing Action and Abstract Emotion Words? Evidence from Focal Brain Lesions

PubMed Central

Dreyer, Felix R.; Frey, Dietmar; Arana, Sophie; von Saldern, Sarah; Picht, Thomas; Vajkoczy, Peter; Pulvermüller, Friedemann

2015-01-01

Neuroimaging and neuropsychological experiments suggest that modality-preferential cortices, including motor- and somatosensory areas, contribute to the semantic processing of action related concrete words. Still, a possible role of sensorimotor areas in processing abstract meaning remains under debate. Recent fMRI studies indicate an involvement of the left sensorimotor cortex in the processing of abstract-emotional words (e.g., “love”) which resembles activation patterns seen for action words. But are the activated areas indeed necessary for processing action-related and abstract words? The current study now investigates word processing in two patients suffering from focal brain lesion in the left frontocentral motor system. A speeded Lexical Decision Task on meticulously matched word groups showed that the recognition of nouns from different semantic categories – related to food, animals, tools, and abstract-emotional concepts – was differentially affected. Whereas patient HS with a lesion in dorsolateral central sensorimotor systems next to the hand area showed a category-specific deficit in recognizing tool words, patient CA suffering from lesion centered in the left supplementary motor area was primarily impaired in abstract-emotional word processing. These results point to a causal role of the motor cortex in the semantic processing of both action-related object concepts and abstract-emotional concepts and therefore suggest that the motor areas previously found active in action-related and abstract word processing can serve a meaning-specific necessary role in word recognition. The category-specific nature of the observed dissociations is difficult to reconcile with the idea that sensorimotor systems are somehow peripheral or ‘epiphenomenal’ to meaning and concept processing. Rather, our results are consistent with the claim that cognition is grounded in action and perception and based on distributed action perception circuits reaching into modality-preferential cortex. PMID:26617535

Ultracentrifuge for separating fluid mixtures

DOEpatents

Lowry, Ralph A.

1976-01-01

1. A centrifuge for the separation of fluid mixtures having light and heavy fractions comprising a cylindrical rotor, disc type end-plugs closing the ends of the rotor, means for mounting said rotor for rotation about its cylindrical axis, a housing member enclosing the rotor, a vacuum chamber in said housing about the central portion of the rotor, a collection chamber at each end of the housing, the innermost side of which is substantially formed by the outer face of the end-plug, means for preventing flow of the fluid from the collection chambers to said vacuum chamber, at least one of said end-plugs having a plurality of holes therethrough communicating between the collection chamber adjacent thereto and the inside of the rotor to induce countercurrent flow of the fluid in the centrifuge, means for feeding fluid to be processed into the centrifuge, means communicating with the collection chambers to extract the light and heavy separated fractions of the fluid, and means for rotating the rotor.

Optimizing the Logistics of Anaerobic Digestion of Manure

NASA Astrophysics Data System (ADS)

Ghafoori, Emad; Flynn, Peter C.

Electrical power production from the combustion of biogas from anaerobic digestion (AD) of manure is a means of recovering energy from animal waste. We evaluate the lowest cost method of moving material to and from centralized AD plants serving multiple confined feeding operations. Two areas are modeled, Lethbridge County, Alberta, Canada, an area of concentrated beef cattle feedlots, and Red Deer County, Alberta, a mixed-farming area with hog, dairy, chicken and beef cattle farms, and feedlots. We evaluate two types of AD plant: ones that return digestate to the source confined feeding operation for land spreading (current technology), and ones that process digestate to produce solid fertilizer and a dischargeable water stream (technology under development). We evaluate manure and digestate trucking, trucking of manure with return of digestate by pipelines, and pipelining of manure plus digestate. We compare the overall cost of power from these scenarios to farm or feedlot-based AD units. For a centralized AD plant with digestate return for land spreading the most economical transport option for manure plus digestate is by truck for the mixed-farming area and by pipelines for the concentrated feedlot area. For a centralized AD plant with digestate processing, the most economical transport option is trucking of manure for both cases.

Analysis of pre-heated fuel combustion and heat-emission dynamics in a diesel engine

NASA Astrophysics Data System (ADS)

Plotnikov, S. A.; Kartashevich, A. N.; Buzikov, S. V.

2018-01-01

The article explores the feasibility of diesel fuel pre-heating. The research goal was to obtain and analyze the performance diagrams of a diesel engine fed with pre-heated fuel. The engine was tested in two modes: at rated RPMs and at maximum torque. To process the diagrams the authors used technique developed by the Central Diesel Research Institute (CDRI). The diesel engine’s heat emission curves were obtained. The authors concluded that fuel pre-heating shortened the initial phase of the combustion process and moderated the loads, thus making it possible to boost a diesel engine’s mean effective pressure.

Implementation of an Antenna Array Signal Processing Breadboard for the Deep Space Network

NASA Technical Reports Server (NTRS)

Navarro, Robert

2006-01-01

The Deep Space Network Large Array will replace/augment 34 and 70 meter antenna assets. The array will mainly be used to support NASA's deep space telemetry, radio science, and navigation requirements. The array project will deploy three complexes in the western U.S., Australia, and European longitude each with 400 12m downlink antennas and a DSN central facility at JPL. THis facility will remotely conduct all real-time monitor and control for the network. Signal processing objectives include: provide a means to evaluate the performance of the Breadboard Array's antenna subsystem; design and build prototype hardware; demonstrate and evaluate proposed signal processing techniques; and gain experience with various technologies that may be used in the Large Array. Results are summarized..

Is the size of the useful field of view affected by postural demands associated with standing and stepping?

PubMed

Reed-Jones, James G; Reed-Jones, Rebecca J; Hollands, Mark A

2014-04-30

The useful field of view (UFOV) is the visual area from which information is obtained at a brief glance. While studies have examined the effects of increased cognitive load on the visual field, no one has specifically looked at the effects of postural control or locomotor activity on the UFOV. The current study aimed to examine the effects of postural demand and locomotor activity on UFOV performance in healthy young adults. Eleven participants were tested on three modified UFOV tasks (central processing, peripheral processing, and divided-attention) while seated, standing, and stepping in place. Across all postural conditions, participants showed no difference in their central or peripheral processing. However, in the divided-attention task (reporting the letter in central vision and target location in peripheral vision amongst distracter items) a main effect of posture condition on peripheral target accuracy was found for targets at 57° of eccentricity (p=.037). The mean accuracy reduced from 80.5% (standing) to 74% (seated) to 56.3% (stepping). These findings show that postural demands do affect UFOV divided-attention performance. In particular, the size of the useful field of view significantly decreases when stepping. This finding has important implications for how the results of a UFOV test are used to evaluate the general size of the UFOV during varying activities, as the traditional seated test procedure may overestimate the size of the UFOV during locomotor activities. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Functional neuronal processing of body odors differs from that of similar common odors.

PubMed

Lundström, Johan N; Boyle, Julie A; Zatorre, Robert J; Jones-Gotman, Marilyn

2008-06-01

Visual and auditory stimuli of high social and ecological importance are processed in the brain by specialized neuronal networks. To date, this has not been demonstrated for olfactory stimuli. By means of positron emission tomography, we sought to elucidate the neuronal substrates behind body odor perception to answer the question of whether the central processing of body odors differs from perceptually similar nonbody odors. Body odors were processed by a network that was distinctly separate from common odors, indicating a separation in the processing of odors based on their source. Smelling a friend's body odor activated regions previously seen for familiar stimuli, whereas smelling a stranger activated amygdala and insular regions akin to what has previously been demonstrated for fearful stimuli. The results provide evidence that social olfactory stimuli of high ecological relevance are processed by specialized neuronal networks similar to what has previously been demonstrated for auditory and visual stimuli.

Music and language perception: expectations, structural integration, and cognitive sequencing.

PubMed

Tillmann, Barbara

2012-10-01

Music can be described as sequences of events that are structured in pitch and time. Studying music processing provides insight into how complex event sequences are learned, perceived, and represented by the brain. Given the temporal nature of sound, expectations, structural integration, and cognitive sequencing are central in music perception (i.e., which sounds are most likely to come next and at what moment should they occur?). This paper focuses on similarities in music and language cognition research, showing that music cognition research provides insight into the understanding of not only music processing but also language processing and the processing of other structured stimuli. The hypothesis of shared resources between music and language processing and of domain-general dynamic attention has motivated the development of research to test music as a means to stimulate sensory, cognitive, and motor processes. Copyright © 2012 Cognitive Science Society, Inc.

Quaternary gravitational morpho-genesis of Central Apennines (Italy): Insights from the Mt. Genzana case history

NASA Astrophysics Data System (ADS)

Esposito, C.; Bianchi-Fasani, G.; Martino, S.; Scarascia-Mugnozza, G.

2013-10-01

This paper focuses on a study aimed at defining the role of geological-structural setting and Quaternary morpho-structural evolution on the onset and development of a deep-seated gravitational slope deformation which affects the western slope of Mt. Genzana ridge (Central Apennines, Italy). This case history is particularly significant as it comprises several aspects of such gravitational processes both in general terms and with particular reference to the Apennines. In fact: i) the morpho-structural setting is representative of widespread conditions in Central Apennines; ii) the deforming slope partially evolved in a large rockslide-avalanche; iii) the deformational process provides evidence of an ongoing state of activity; iv) the rockslide-avalanche debris formed a stable natural dam, thus implying significant variations in the morphologic, hydraulic and hydrogeological setting; v) the gravitational deformation as well as the rockslide-avalanche reveal a strong structural control. The main study activities were addressed to define a detailed geological model of the gravity-driven process, by means of geological, structural, geomorphological and geomechanical surveys. As a result, a robust hypothesis about the kinematics of the process was possible, with particular reference to the identification of geological-structural constraints. The process, in fact, involves a specific section of the slope exactly where a dextral transtensional structure is present, thus implying local structural conditions that favor sliding processes: the rock mass is intensively jointed by high angle discontinuity sets and the bedding attitude is quite parallel to the slope angle. Within this frame the gravitational process can be classified as a structurally constrained translational slide, locally evolved into a rockslide-avalanche. The activation of such a deformation can be in its turn related to the Quaternary morphological evolution of the area, which was affected by a significant topographic stress increase, testified by stratigraphic and morphologic evidence.

Simple dynamical models capturing the key features of the Central Pacific El Niño.

PubMed

Chen, Nan; Majda, Andrew J

2016-10-18

The Central Pacific El Niño (CP El Niño) has been frequently observed in recent decades. The phenomenon is characterized by an anomalous warm sea surface temperature (SST) confined to the central Pacific and has different teleconnections from the traditional El Niño. Here, simple models are developed and shown to capture the key mechanisms of the CP El Niño. The starting model involves coupled atmosphere-ocean processes that are deterministic, linear, and stable. Then, systematic strategies are developed for incorporating several major mechanisms of the CP El Niño into the coupled system. First, simple nonlinear zonal advection with no ad hoc parameterization of the background SST gradient is introduced that creates coupled nonlinear advective modes of the SST. Secondly, due to the recent multidecadal strengthening of the easterly trade wind, a stochastic parameterization of the wind bursts including a mean easterly trade wind anomaly is coupled to the simple atmosphere-ocean processes. Effective stochastic noise in the wind burst model facilitates the intermittent occurrence of the CP El Niño with realistic amplitude and duration. In addition to the anomalous warm SST in the central Pacific, other major features of the CP El Niño such as the rising branch of the anomalous Walker circulation being shifted to the central Pacific and the eastern Pacific cooling with a shallow thermocline are all captured by this simple coupled model. Importantly, the coupled model succeeds in simulating a series of CP El Niño that lasts for 5 y, which resembles the two CP El Niño episodes during 1990-1995 and 2002-2006.

Local and regional components of aerosol in a heavily trafficked street canyon in central London derived from PMF and cluster analysis of single-particle ATOFMS spectra.

PubMed

Giorio, Chiara; Tapparo, Andrea; Dall'Osto, Manuel; Beddows, David C S; Esser-Gietl, Johanna K; Healy, Robert M; Harrison, Roy M

2015-03-17

Positive matrix factorization (PMF) has been applied to single particle ATOFMS spectra collected on a six lane heavily trafficked road in central London (Marylebone Road), which well represents an urban street canyon. PMF analysis successfully extracted 11 factors from mass spectra of about 700,000 particles as a complement to information on particle types (from K-means cluster analysis). The factors were associated with specific sources and represent the contribution of different traffic related components (i.e., lubricating oils, fresh elemental carbon, organonitrogen and aromatic compounds), secondary aerosol locally produced (i.e., nitrate, oxidized organic aerosol and oxidized organonitrogen compounds), urban background together with regional transport (aged elemental carbon and ammonium) and fresh sea spray. An important result from this study is the evidence that rapid chemical processes occur in the street canyon with production of secondary particles from road traffic emissions. These locally generated particles, together with aging processes, dramatically affected aerosol composition producing internally mixed particles. These processes may become important with stagnant air conditions and in countries where gasoline vehicles are predominant and need to be considered when quantifying the impact of traffic emissions.

Directionality of real world networks as predicted by path length in directed and undirected graphs

NASA Astrophysics Data System (ADS)

Rosen, Yonatan; Louzoun, Yoram

2014-05-01

Many real world networks either support ordered processes, or are actually representations of such processes. However, the same networks contain large strong connectivity components and long circles, which hide a possible inherent order, since each vertex can be reached from each vertex in a directed path. Thus, the presence of an inherent directionality in networks may be hidden. We here discuss a possible definition of such a directionality and propose a method to detect it. Several common algorithms, such as the betweenness centrality or the degree, measure various aspects of centrality in networks. However, they do not address directly the issue of inherent directionality. The goal of the algorithm discussed here is the detection of global directionality in directed networks. Such an algorithm is essential to detangle complex networks into ordered process. We show that indeed the vast majority of measured real world networks have a clear directionality. Moreover, this directionality can be used to classify vertices in these networks from sources to sinks. Such an algorithm can be highly useful in order to extract a meaning from large interaction networks assembled in many domains.

The Toxicity of Inhaled Sulphur Mustard

DTIC Science & Technology

2012-10-01

Index − CO – Cardiac Output − CvO2 – Mixed Venous Oxygenation − CVP – Central Venous Pressure − DO2 – Oxygen Delivery − dpMax – Maximum...in central venous pressure following exposure to HD: HD controls () and HD + NAC (). Data are expressed as mean ± SEM. UK UNCLASSIFIED Page 64 of...Respiratory rate (RR) Heart rate (HR) Expired CO2 Pulse oximetry Mean arterial pressure Central venous pressure Blood Chemistry (arterial and

Comparison of right atrial pressure and central venous pressures measured at various anatomical locations in children.

PubMed

Lin, Ming-Chih; Fu, Yun-Ching; Jan, Sheng-Ling; Chen, Ying-Tsung; Chi, Ching-Shiang

2005-01-01

To compare the right atrial pressure to the central venous pressures measured at different points in spontaneously breathing children and try to find a formula to estimate right atrial pressure by central venous pressure measurement. Fifty-one children, aged 5 +/- 4.7 years, who underwent right heart catheterization were studied. All patients were sedated and breathed naturally. The mean pressure was the electronic mean of nine heart beats calculated by Philips BC4000 digital angiographic system. Mean pressure of the right atrium was compared to those measured at the high superior vena cava (SVC), low SVC, high inferior vena cava (IVC) (T10-11), middle IVC (L1-2), low IVC (L3-4), and iliac vein (L5-S1). Mean pressures of central veins were significantly higher than that of the right atrium (all p<0.01). Adjusted central venous pressures of SVC-0.5, high IVC-1.5, middle IVC-2, low IVC-2.5, and iliac vein-3 (mmHg) had a good agreement with the right atrial pressure. Central venous pressures are significantly higher than the right atrial pressure in spontaneously breathing children. Adjusted pressures of SVC-0.5, high IVC-1.5, middle IVC-2, low IVC-2.5, and iliac vein-3 (mmHg) can accurately reflect the right atrial pressure.

A 60-year reconstructed high-resolution local meteorological data set in Central Sahel (1950-2009): evaluation, analysis and application to land surface modelling

NASA Astrophysics Data System (ADS)

Leauthaud, Crystele; Cappelaere, Bernard; Demarty, Jérôme; Guichard, Françoise; Velluet, Cécile; Kergoat, Laurent; Vischel, Théo; Grippa, Manuela; Mouhaimouni, Mohammed; Bouzou Moussa, Ibrahim; Mainassara, Ibrahim; Sultan, Benjamin

2017-04-01

The Sahel has experienced strong climate variability in the past decades. Understanding its implications for natural and cultivated ecosystems is pivotal in a context of high population growth and mainly agriculture-based livelihoods. However, efforts to model processes at the land-atmosphere interface are hindered, particularly when the multi-decadal timescale is targeted, as climatic data are scarce, largely incomplete and often unreliable. This study presents the generation of a long-term, high-temporal resolution, multivariate local climatic data set for Niamey, Central Sahel. The continuous series spans the period 1950-2009 at a 30-min timescale and includes ground station-based meteorological variables (precipitation, air temperature, relative and specific humidity, air pressure, wind speed, downwelling long- and short-wave radiation) as well as process-modelled surface fluxes (upwelling long- and short-wave radiation,latent, sensible and soil heat fluxes and surface temperature). A combination of complementary techniques (linear/spline regressions, a multivariate analogue method, artificial neural networks and recursive gap filling) was used to reconstruct missing meteorological data. The complete surface energy budget was then obtained for two dominant land cover types, fallow bush and millet, by applying the meteorological forcing data set to a finely field-calibrated land surface model. Uncertainty in reconstructed data was expressed by means of a stochastic ensemble of plausible historical time series. Climatological statistics were computed at sub-daily to decadal timescales and compared with local, regional and global data sets such as CRU and ERA-Interim. The reconstructed precipitation statistics, ˜1°C increase in mean annual temperature from 1950 to 2009, and mean diurnal and annual cycles for all variables were in good agreement with previous studies. The new data set, denoted NAD (Niamey Airport-derived set) and publicly available, can be used to investigate the water and energy cycles in Central Sahel, while the methodology can be applied to reconstruct series at other stations. The study has been published in Int. J. Climatol. (2016), DOI: 10.1002/joc.4874

Application of rotatable central composite design in the preparation and optimization of poly(lactic-co-glycolic acid) nanoparticles for controlled delivery of paclitaxel.

PubMed

Kollipara, Sivacharan; Bende, Girish; Movva, Snehalatha; Saha, Ranendra

2010-11-01

Polymeric carrier systems of paclitaxel (PCT) offer advantages over only available formulation Taxol® in terms of enhancing therapeutic efficacy and eliminating adverse effects. The objective of the present study was to prepare poly (lactic-co-glycolic acid) nanoparticles containing PCT using emulsion solvent evaporation technique. Critical factors involved in the processing method were identified and optimized by scientific, efficient rotatable central composite design aiming at low mean particle size and high entrapment efficiency. Twenty different experiments were designed and each formulation was evaluated for mean particle size and entrapment efficiency. The optimized formulation was evaluated for in vitro drug release, and absorption characteristics were studied using in situ rat intestinal permeability study. Amount of polymer and duration of ultrasonication were found to have significant effect on mean particle size and entrapment efficiency. First-order interactions of amount of miglyol with amount of polymer were significant in case of mean particle size, whereas second-order interactions of polymer were significant in mean particle size and entrapment efficiency. The developed quadratic model showed high correlation (R(2) > 0.85) between predicted response and studied factors. The optimized formulation had low mean particle size (231.68 nm) and high entrapment efficiency (95.18%) with 4.88% drug content. The optimized formulation showed controlled release of PCT for more than 72 hours. In situ absorption study showed faster and enhanced extent of absorption of PCT from nanoparticles compared to pure drug. The poly (lactic-co-glycolic acid) nanoparticles containing PCT may be of clinical importance in enhancing its oral bioavailability.

Towards elicitation of users requirements for hospital information system: from a care process modelling technique to a web based collaborative tool.

PubMed Central

Staccini, Pascal M.; Joubert, Michel; Quaranta, Jean-Francois; Fieschi, Marius

2002-01-01

Growing attention is being given to the use of process modeling methodology for user requirements elicitation. In the analysis phase of hospital information systems, the usefulness of care-process models has been investigated to evaluate the conceptual applicability and practical understandability by clinical staff and members of users teams. Nevertheless, there still remains a gap between users and analysts in their mutual ability to share conceptual views and vocabulary, keeping the meaning of clinical context while providing elements for analysis. One of the solutions for filling this gap is to consider the process model itself in the role of a hub as a centralized means of facilitating communication between team members. Starting with a robust and descriptive technique for process modeling called IDEF0/SADT, we refined the basic data model by extracting concepts from ISO 9000 process analysis and from enterprise ontology. We defined a web-based architecture to serve as a collaborative tool and implemented it using an object-oriented database. The prospects of such a tool are discussed notably regarding to its ability to generate data dictionaries and to be used as a navigation tool through the medium of hospital-wide documentation. PMID:12463921

Towards elicitation of users requirements for hospital information system: from a care process modelling technique to a web based collaborative tool.

PubMed

Staccini, Pascal M; Joubert, Michel; Quaranta, Jean-Francois; Fieschi, Marius

2002-01-01

Growing attention is being given to the use of process modeling methodology for user requirements elicitation. In the analysis phase of hospital information systems, the usefulness of care-process models has been investigated to evaluate the conceptual applicability and practical understandability by clinical staff and members of users teams. Nevertheless, there still remains a gap between users and analysts in their mutual ability to share conceptual views and vocabulary, keeping the meaning of clinical context while providing elements for analysis. One of the solutions for filling this gap is to consider the process model itself in the role of a hub as a centralized means of facilitating communication between team members. Starting with a robust and descriptive technique for process modeling called IDEF0/SADT, we refined the basic data model by extracting concepts from ISO 9000 process analysis and from enterprise ontology. We defined a web-based architecture to serve as a collaborative tool and implemented it using an object-oriented database. The prospects of such a tool are discussed notably regarding to its ability to generate data dictionaries and to be used as a navigation tool through the medium of hospital-wide documentation.

Electromagnetic tornadoes in space. Ion conics along auroral field lines generated by lower hybrid waves and electromagnetic turbulence in the ion-cyclotron range of frequencies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, T.; Crew, G.B.; Retterer, J.M.

1988-01-01

The exotic phenomenon of energetic ion-conic formation by plasma waves in the magnetosphere is considered. Two particular transverse heating mechanisms are reviewed in detail: lower-hybrid energization of ions in the boundary layer of the plasma sheet, and electromagnetic ion cyclotron resonance heating in the central region of the plasma sheet. Mean particle calculations, plasma simulations, and analytical treatments of the heating processes are described.

Calculation of the diameter of the central retinal artery from noninvasive measurements in humans.

PubMed

Dorner, Guido T; Polska, Elzbieta; Garhöfer, Gerhard; Zawinka, Claudia; Frank, Barbara; Schmetterer, Leopold

2002-12-01

The aim of the present study was to calculate the diameter of the central retinal artery from results as obtained with non-invasive techniques in healthy young subjects. Twenty-four healthy male subjects participated in this study. Total retinal blood flow was calculated from combined bi-directional laser Doppler velocimetry and measurement of retinal venous diameters using the Zeiss retinal vessel analyzer. Using these techniques red blood cell velocity and vessel diameters of all visible veins entering the optic nerve head were measured and total retinal blood flow was calculated. Blood flow velocity in the central retinal artery was measured with color Doppler imaging. Form these outcome parameters the diameter of the central retinal artery was calculated for each subject individually. In the present study cohort the mean retinal blood flow was 38.1 +/- 9.1 microl/min and the mean flow velocity in the central retinal artery was 6.3 +/- 1.2 cm/s. From these data we calculated a mean diameter of the central retinal artery of 163 +/- 17 microm. Our results are in good agreement with data obtained from in vitro studies. The data of the present study also indicate that one needs to be careful to interpret velocity data from the central retinal artery in terms of retinal blood flow.

Reactivation of a Deep Seated Gravitational Slope Deformation observed during the recent seismic events in Central Italy.

NASA Astrophysics Data System (ADS)

Amato, Gabriele; Aringoli, Domenico; Devoti, Roberto; Fubelli, Giandomenico; Galvani, Alessandro; Pambianchi, Gilberto; Sepe, Vincenzo

2017-04-01

Deep-Seated Gravitational Slope Deformations (DSGSDs) represent an important geomorphological feature of the European mountain chains and several cases from Central Apennine (Italy) are accurately described in literature. These phenomena generally present evident geomorphological markers (e.g. double ridges, trenches, counterslopes) and low activity rates (i.e. mm to cm per year), which can be triggered by many different means (e.g. seismic activity, erosional processes, rainfall, post-glacial debuttressing). To understand which is the most influential factor in DSGSDs' activity is rarely an easy task because this can vary from case to case. This work illustrates the outcomes provided by a monitoring activity conducted along the Mt. Frascare slope (Fiastra Lake, Marche region, Italy). The monitoring system is composed by 4 low cost GPS stations, based on single-frequency receivers, and 2 double-frequency GPS stations, aimed to cross-check the surface deformations measured by the two types of monitoring stations. The 6 GPS stations have been operated in place starting from October 2014 grounded on the base of a geomorphological field survey of the investigated phenomenon. Two stations have been equipped with both receiver types in order to facilitate the comparison of the results. The Fiastra DSGSD affects a marly limestone bedrock throughout a >5km2 area and along a slope against which a dam for hydroelectric power leans. Our monitoring system allowed to measure the Fiastra DSGSD's seismically induced relative displacements on the order of two mean steps of about 10 cm, due to the recent seismic sequence occurred in Central Italy in 2016, which resulted considerably higher than the observed mean annual velocity (≈5mm/y).

9 CFR 93.320 - Horses from Central America and the West Indies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Horses from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Central America and the West Indies 17 § 93.320 Horses from Central America and the West Indies. Horses from Central America and the...

9 CFR 93.320 - Horses from Central America and the West Indies.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Horses from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Central America and the West Indies 17 § 93.320 Horses from Central America and the West Indies. Horses from Central America and the...

9 CFR 93.320 - Horses from Central America and the West Indies.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Horses from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Central America and the West Indies 17 § 93.320 Horses from Central America and the West Indies. Horses from Central America and the...

9 CFR 93.320 - Horses from Central America and the West Indies.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Horses from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Central America and the West Indies 17 § 93.320 Horses from Central America and the West Indies. Horses from Central America and the...

9 CFR 93.320 - Horses from Central America and the West Indies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Horses from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Central America and the West Indies 17 § 93.320 Horses from Central America and the West Indies. Horses from Central America and the...

The Effect of Highlighting on Processing and Memory of Central and Peripheral Text Information: Evidence from Eye Movements

ERIC Educational Resources Information Center

Yeari, Menahem; Oudega, Marja; van den Broek, Paul

2017-01-01

The present study investigated the effect of text highlighting on online processing and memory of central and peripheral information. We compared processing time (using eye-tracking methodology) and recall of central and peripheral information for three types of highlighting: (a) highlighting of central information, (b) highlighting of peripheral…

Mechlorethamine-based drug structures for intervention of central nervous system tumors.

PubMed

Bartzatt, Ronald

2013-06-01

Tumors of the central nervous system are the third most common type of childhood cancers. Brain tumors occur in children and adults; however pediatric patients require a different treatment process. Thirteen drugs similar to mechlorethamine are analyzed in this study. These drugs possess molecular properties enabling substantial and successful access to tumors of the central nervous system. All drugs exhibit zero violations of the Rule of 5, which indicate favorable bioavailability. Ranges in Log P, formula weight, and polar surface area for these drugs are: 1.554 to 3.52, 156.06 to 460.45, and 3.238 Angstroms(2) to 45.471 Angstroms(2), respectively. Hierarchical cluster analysis determined that agents 7 and 12 are most similar to the parent compound mechlorethamine. The mean values of Log P, formula weight, polar surface area, and molecular volume are 2.25, 268.51, 16.57 Angstroms(2), and 227.01 Angstroms(3), respectively. Principal component analysis indicates that agents 7 and 12 are most similar to mechlorethamine and multiple regression analysis of molecular properties produced a model to enable the design of similar alkylating agents. Values of Log (Cbrain/Cblood) indicate these agents will have very high permeation into the central nervous system.

Centralized drug review processes: are they fair?

PubMed

Mitton, Craig R; McMahon, Meghan; Morgan, Steve; Gibson, Jennifer

2006-07-01

Numerous countries have implemented centralized drug review processes to assist in making drug coverage decisions. In addition to examining the final recommendations of these bodies, it is also important to ensure fairness in decision making. Accountability for reasonableness is an ethics-based framework for examining the fairness of priority setting processes. The objective of this study was to assess the fairness of four internationally established centralized drug review processes using accountability for reasonableness. Semi-structured telephone interviews were conducted with stakeholders in Canada, New Zealand, Australia and the UK (n=16). Participants were asked to evaluate their country's centralized drug review process against the four conditions of accountability for reasonableness. Each centralized drug review process satisfied at least one of the four ethical conditions, but none satisfied all four conditions. All participants viewed transparency as critical to both the legitimacy and fairness of centralized drug review processes. Additional strides need to be made in each of the four countries under study to improve the fairness of their centralized drug review processes. Ideally, a fair priority setting process should foster constructive stakeholder engagement and enhance the legitimacy of decisions made in assessing pharmaceutical products for funding. As policy makers are under increasing scrutiny in allocating limited resources, fair process should be seen as a critical component of such activity. This study represents the first attempt to conduct an international comparison of the fairness of centralized drug review agencies in the eyes of participating stakeholders.

Central depression of nuclear charge density distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu Yanyun; Ren Zhongzhou; Center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator, Lanzhou 730000

The center-depressed nuclear charge distributions are investigated with the parametrized distribution and the relativistic mean-field theory, and their corresponding charge form factors are worked out with the phase shift analysis method. The central depression of nuclear charge distribution of {sup 46}Ar and {sup 44}S is supported by the relativistic mean-field calculation. According to the calculation, the valence protons in {sup 46}Ar and {sup 44}S prefer to occupy the 1d{sub 3/2} state rather than the 2s{sub 1/2} state, which is different from that in the less neutron-rich argon and sulfur isotopes. As a result, the central proton densities of {sup 46}Armore » and {sup 44}S are highly depressed, and so are their central charge densities. The charge form factors of some argon and sulfur isotopes are presented, and the minima of the charge form factors shift upward and inward when the central nuclear charge distributions are more depressed. Besides, the effect of the central depression on the charge form factors is studied with a parametrized distribution, when the root-mean-square charge radii remain constant.« less

Towards a mechanistic foundation of evolutionary theory.

PubMed

Doebeli, Michael; Ispolatov, Yaroslav; Simon, Burt

2017-02-15

Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathematical descriptions of evolution. Instead, we propose that evolutionary birth-death processes, in which individuals give birth and die at ever-changing rates, should be the basis of evolutionary theory, because such processes capture the fundamental events that generate evolutionary dynamics. In evolutionary birth-death processes, fitness is at best a derived quantity, and owing to the potential complexity of such processes, there is no guarantee that there is a simple scalar, such as fitness, that would describe long-term evolutionary outcomes. We discuss how evolutionary birth-death processes can provide useful perspectives on a number of central issues in evolution.

Changes in denudation rates and erosion processes in the transition from a low-relief, arid orogen interior to a high-relief, humid mountain-front setting, Toro Basin, southern Central Andes

NASA Astrophysics Data System (ADS)

Tofelde, S.; Düsing, W.; Schildgen, T. F.; Wittmann, H.; Alonso, R. N.; Strecker, M. R.

2017-12-01

In tectonically active mountain belts positive correlations between denudation rates and hillslope angles are commonly observed, supporting the notion that landscape morphology may reflect tectonic forcing. However, this relationship generally breaks down at 30°, when hillslopes reach threshold angles. Beyond this threshold, faster denudation may occur by an increased contribution from mass-wasting processes. We test this idea in the 4000 km2 Toro Basin, a fault-bounded basin in the Eastern Cordillera of the southern Central Andes. This N-S oriented basin is located between low-relief, arid conditions in the orogen interior (N) and a high-relief, humid setting at its fluvial outlet (S). We measured in-situ produced 10Be concentration in fluvial sediments, which can be converted into basin-mean denudation rates, assuming a spatially uniform contribution of sediment from the catchment. However, in landslide-influenced areas, this assumption is often violated. Previous studies have suggested that clast-size material is mainly contributed by mass-wasting processes, whereas sand is derived from a broad range of erosional processes. Hence, a combination of clast and sand samples can reveal information about the basin-mean denudation rate as well as the contribution of mass-wasting processes. We sampled 13 pebble (1-3 cm) and sand (250-500 µm) pairs across the basin. The sand-derived denudation rates increase from N to S, ranging from 0.010 mm/yr to 1.337 mm/yr, and reveal a non-linear positive correlation with median basin slope. The clast/sand ratios also increase from N to S, indicating amplified mass-wasting processes with increasing slopes. To test if our ratios represent a real shift in erosional processes, we mapped different erosional processes in the study area (e.g. deep-seated landslides, scree erosion,.., diffusion). We assume that today's distribution of processes has not changed over the integration time of 10Be derived denudation rates. This detailed erosion inventory indicates a shift in the dominant erosional processes with increasing clast/sand ratios and thus with increasing slopes. We provide empirical data supporting the hypothesis that higher denudation rates can be achieved by an increased contribution of mass-wasting processes after threshold slopes have been reached.

Are visual peripheries forever young?

PubMed

Burnat, Kalina

2015-01-01

The paper presents a concept of lifelong plasticity of peripheral vision. Central vision processing is accepted as critical and irreplaceable for normal perception in humans. While peripheral processing chiefly carries information about motion stimuli features and redirects foveal attention to new objects, it can also take over functions typical for central vision. Here I review the data showing the plasticity of peripheral vision found in functional, developmental, and comparative studies. Even though it is well established that afferent projections from central and peripheral retinal regions are not established simultaneously during early postnatal life, central vision is commonly used as a general model of development of the visual system. Based on clinical studies and visually deprived animal models, I describe how central and peripheral visual field representations separately rely on early visual experience. Peripheral visual processing (motion) is more affected by binocular visual deprivation than central visual processing (spatial resolution). In addition, our own experimental findings show the possible recruitment of coarse peripheral vision for fine spatial analysis. Accordingly, I hypothesize that the balance between central and peripheral visual processing, established in the course of development, is susceptible to plastic adaptations during the entire life span, with peripheral vision capable of taking over central processing.

Accessing and selecting word meaning in autism spectrum disorder.

PubMed

Henderson, L M; Clarke, P J; Snowling, M J

2011-09-01

Comprehension difficulties are commonly reported in autism spectrum disorder (ASD) but the causes of these difficulties are poorly understood. This study investigates how children with ASD access and select meanings of ambiguous words to test four hypotheses regarding the nature of their comprehension difficulties: semantic deficit, weak central coherence, reduced top-down control and inhibition deficit. The cross-modal semantic priming paradigm was used. Children heard homonym primes in isolation or as final words in sentences biased towards the subordinate meaning and then named picture targets depicting dominant or subordinate associates of homonyms. When homonyms were presented in isolation, children with ASD and controls showed priming for dominant and subordinate pictures at 250ms ISI. At 1,000ms ISI, the controls showed dominant (but not subordinate) priming whilst the ASD group did not show any priming. When homonyms were presented in subordinate sentence contexts, both groups only showed priming for context-appropriate (subordinate) meanings at 250ms ISI, suggesting that context has an early influence on meaning selection. At 1,000ms ISI the controls showed context-appropriate (but not inappropriate) priming whereas the ASD group showed both appropriate and inappropriate priming. Children with ASD showed intact access to semantic information early in the time course of processing; however, they showed impairments in the selection of semantic representations later in processing. These findings suggest that a difficulty with initiating top-down strategies to modulate online semantic processing may compromise language comprehension in ASD. Implications for intervention are discussed. © 2011 The Authors. Journal of Child Psychology and Psychiatry © 2011 Association for Child and Adolescent Mental Health.

The relationship of centralization, organizational culture and performance indexes in teaching hospitals affiliated to Tehran University of Medical Sciences.

PubMed

Nasirpour, Amir Ashkan; Gohari, Mahmoud Reza; Moradi, Saied

2010-01-01

One of the main problems in the efficiency and efficacy of an organization is its structural issue. Organizational culture is also considered as an effective factor in the performance of many organizations. The main goal of the present study was to determine the relationship of Centralization and organizational culture and performance indexes in Teaching Hospitals affiliated to Tehran University of Medical Sciences. This correlation study was performed in the year 2007. The population studied consisted of 4408 personnel from 13 hospitals among whom 441 subjects were selected and studied via a class sampling method. Data was compiled using a check list concerning the evaluation status of Centralization and another form concerning performance indexes as well as Robbin's organizational culture questionnaire. Data were obtained from the subjects by self answering and analyzed by using descriptive statistical indexes, T- test and Fisher's exact tests. Among the organizational culture indexes of the hospitals studied, control and organizational identity was better as compared to others (mean=3.32 and 3.30). Concerning the extent of Centralization in the hospitals studied, 53.85 % and 46.15 % were reported to have upper and lower organizational Centralization, respectively. Mean ratio of surgical operations to inpatients was 40%, the mean rate of admissions per active bed was 60.83, mean bed occupancy coefficient was 70.79%, average length of stay was 6.96 days, and mean net death rate was 1.41%. No significant correlation was seen between Centralization degree, organizational culture and performance indexes in teaching hospitals Tehran university of medical sciences. (with 95% confidence interval). Due to the fact that first grade Teaching hospitals use board certified members, expert personnel, and advanced equipments and because of the limitation of patients choice and, the extent of Centralization and many organizational culture components have no significant correlation with performance indexes of these hospitals. Further research regarding structure is suggested in the future.

A new species of Amaralia Fowler (Siluriformes: Aspredinidae) from the Paraná-Paraguay River Basin.

PubMed

Friel, John P; Carvalho, Tiago P

2016-03-11

A new species of the banjo catfish genus Amaralia is described from the Paraná-Paraguay River Basin in central-western Brazil, Paraguay and northern Argentina. Amaralia oviraptor is distinguished from its single and allopatric congener, Amaralia hypsiura, by the greater number of dorsal-fin rays (3 vs. 2); by the absence of lateral contact between middle and posterior nuchal plates (vs. middle and posterior nuchal plates contacting each other laterally); and by a longer cleithral process (17.4-19.5 % of SL, mean 18.2 % vs. 14.0-17.2 % of SL, mean=15.5 %). Comments on the peculiar oophagic diet of Amaralia and an extended diagnosis of the genus are provided.

Informing Hospital Change Processes through Visualization and Simulation: A Case Study at a Children's Emergency Clinic.

PubMed

Persson, Johanna; Dalholm, Elisabeth Hornyánszky; Johansson, Gerd

2014-01-01

To demonstrate the use of visualization and simulation tools in order to involve stakeholders and inform the process in hospital change processes, illustrated by an empirical study from a children's emergency clinic. Reorganization and redevelopment of a hospital is a complex activity that involves many stakeholders and demands. Visualization and simulation tools have proven useful for involving practitioners and eliciting relevant knowledge. More knowledge is desired about how these tools can be implemented in practice for hospital planning processes. A participatory planning process including practitioners and researchers was executed over a 3-year period to evaluate a combination of visualization and simulation tools to involve stakeholders in the planning process and to elicit knowledge about needs and requirements. The initial clinic proposal from the architect was discarded as a result of the empirical study. Much general knowledge about the needs of the organization was extracted by means of the adopted tools. Some of the tools proved to be more accessible than others for the practitioners participating in the study. The combination of tools added value to the process by presenting information in alternative ways and eliciting questions from different angles. Visualization and simulation tools inform a planning process (or other types of change processes) by providing the means to see beyond present demands and current work structures. Long-term involvement in combination with accessible tools is central for creating a participatory setting where the practitioners' knowledge guides the process. © 2014 Vendome Group, LLC.

The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context

PubMed Central

Ellingsen, Dan-Mikael; Leknes, Siri; Løseth, Guro; Wessberg, Johan; Olausson, Håkan

2016-01-01

Inter-individual touch can be a desirable reward that can both relieve negative affect and evoke strong feelings of pleasure. However, if other sensory cues indicate it is undesirable to interact with the toucher, the affective experience of the same touch may be flipped to disgust. While a broad literature has addressed, on one hand the neurophysiological basis of ascending touch pathways, and on the other hand the central neurochemistry involved in touch behaviors, investigations of how external context and internal state shapes the hedonic value of touch have only recently emerged. Here, we review the psychological and neurobiological mechanisms responsible for the integration of tactile “bottom–up” stimuli and “top–down” information into affective touch experiences. We highlight the reciprocal influences between gentle touch and contextual information, and consider how, and at which levels of neural processing, top-down influences may modulate ascending touch signals. Finally, we discuss the central neurochemistry, specifically the μ-opioids and oxytocin systems, involved in affective touch processing, and how the functions of these neurotransmitters largely depend on the context and motivational state of the individual. PMID:26779092

Mental Representation in The Thought of Sidney Blatt: Developmental Processes.

PubMed

Auerbach, John S; Diamond, Diana

2017-06-01

Mental representation was a central construct in Sidney Blatt's contributions to psychology and psychoanalysis. This brief review demonstrates that Blatt's understanding of representation was always informed by basic psychoanalytic concepts like the centrality of early caregiver-infant relationships and of unconscious mental processes. Although Blatt's earlier writings were informed by psychoanalytic ego psychology and Piagetian cognitive developmental psychology, they focused nonetheless on how an individual uses bodily and relational experiences to construct an object world; they also consistently presented object representations as having significant unconscious dimensions. From the mid-1980s onward, Blatt's contributions, in dialogue with his many students, moved in an even more experiential/relational direction and manifested the influence of attachment theory, parent-infant interaction research, and intersubjectivity theory. They also incorporated contemporary cognitive psychology, with its emphasis on implicit or procedural, rather than explicit, dimensions as a means of accounting for aspects of object representations that are not in conscious awareness. Throughout his career, however, Blatt regarded mental representation as the construct that mediates between the child's earliest bodily and relational experiences and the mature adult's symbolic, most emotionally profound capacities.

Quantum thermodynamics of general quantum processes.

PubMed

Binder, Felix; Vinjanampathy, Sai; Modi, Kavan; Goold, John

2015-03-01

Accurately describing work extraction from a quantum system is a central objective for the extension of thermodynamics to individual quantum systems. The concepts of work and heat are surprisingly subtle when generalizations are made to arbitrary quantum states. We formulate an operational thermodynamics suitable for application to an open quantum system undergoing quantum evolution under a general quantum process by which we mean a completely positive and trace-preserving map. We derive an operational first law of thermodynamics for such processes and show consistency with the second law. We show that heat, from the first law, is positive when the input state of the map majorizes the output state. Moreover, the change in entropy is also positive for the same majorization condition. This makes a strong connection between the two operational laws of thermodynamics.

Depression in Aboriginal men in central Australia: adaptation of the Patient Health Questionnaire 9

PubMed Central

2013-01-01

Background While Indigenous Australians are believed to be at a high risk of psychological illness, few screening instruments have been designed to accurately measure this burden. Rather than simply transposing western labels of symptoms, this paper describes the process by which a screening tool for depression was specifically adapted for use across multiple Indigenous Australian communities. Method Potential depression screening instruments were identified and interrogated according to a set of pre-defined criteria. A structured process was then developed which relied on the expertise of five focus groups comprising of members from primary Indigenous language groups in central Australia. First, focus group participants were asked to review and select a screening measure for adaptation. Bi-lingual experts then translated and back translated the language within the selected measure. Focus group participants re-visited the difficult items, explored their meaning and identified potential ways to achieve equivalence of meaning. Results All five focus groups independently selected the Primary Health Questionnaire 9, several key conceptual differences were exposed, largely related to the construction of hopelessness. Together with translated versions of each instrument for each of the five languages, a single, simplified English version for use across heterogeneous settings was negotiated. Importantly, the ‘code’ and specific conceptually equivalent words that could be used for other Indigenous language groups were also developed. Conclusions The extensive process of adaptation used in this study has demonstrated that within the context of Indigenous Australian communities, across multiple language groups, where English is often a third or fourth language, conceptual and linguistic equivalence of psychological constructs can be negotiated. A validation study is now required to assess the adapted instrument’s potential for measuring the burden of disease across all Indigenous Australian populations. PMID:24139186

Modern approaches to the design of memory and cognitive function stimulants based on AMPA receptor ligands

NASA Astrophysics Data System (ADS)

Grigoriev, V. V.; Proshin, A. N.; Kinzirsky, A. S.; Bachurin, Sergey O.

2009-05-01

Data on the structure and properties of compounds acting on AMPA receptors, the key subtype of ionotropic glutamate receptors of the mammalian central nervous system, are analyzed. Data on the role of these receptors in provision of memory and cognitive function formation and impairment processes are presented. The attention is focused on the modern views on the mechanisms of AMPA receptor desensitization and deactivation and action of substances affecting these processes. The structures of key positive modulators of AMPA receptors are given. The problems of application of these substances as therapeutic means for preventing and treating neurodegenerative and psychoneurological diseases are discussed. Bibliography — 121 references.

Optimal estimator model for human spatial orientation

NASA Technical Reports Server (NTRS)

Borah, J.; Young, L. R.; Curry, R. E.

1979-01-01

A model is being developed to predict pilot dynamic spatial orientation in response to multisensory stimuli. Motion stimuli are first processed by dynamic models of the visual, vestibular, tactile, and proprioceptive sensors. Central nervous system function is then modeled as a steady-state Kalman filter which blends information from the various sensors to form an estimate of spatial orientation. Where necessary, this linear central estimator has been augmented with nonlinear elements to reflect more accurately some highly nonlinear human response characteristics. Computer implementation of the model has shown agreement with several important qualitative characteristics of human spatial orientation, and it is felt that with further modification and additional experimental data the model can be improved and extended. Possible means are described for extending the model to better represent the active pilot with varying skill and work load levels.

Pain in rheumatic diseases: how relevant is it?

PubMed

Sarzi-Puttini, P; Atzeni, F; Salaffi, F

2014-06-06

Pain, a complex phenomenon influenced by a series of genetic, biological, psychological and social factors, is a major component of many rheumatological conditions and the result of physiological interactions between central and peripheral nervous system signalling. It may be acute or chronic (generally defined as lasting ≥ three months): acute pain is often primarily attributable to inflammation and/or damage to peripheral structures (i.e. nociceptive input), whereas chronic pain is more likely to be due to input from the central nervous system (CNS). The many different aspects of pain mean that rheumatologists and other clinicians need to have enough expertise to diagnose the type of pain correctly and treat it appropriately. However, most rheumatologists receive little formal training concerning contemporary theories of pain processing or management, and this may affect the clinical results of any specific target therapy.

Central Corneal Thickness and its Relationship to Intra-Ocular and Epidmiological Determinants.

PubMed

Tayyab, Ali; Masrur, Amena; Afzal, Farooq; Iqbal, Fyza; Naseem, Kamran

2016-06-01

To measure central corneal thickness in Pakistani population and determine its relationship to intra-ocular pressure, age, gender and ethnicity. Cross-sectional observation study. Pakistan Institute of Medical Sciences, Islamabad, Pakistan, between December 2013 and February 2015. The right eyes of 1000 cases (496 males and 504 females) were recruited for this study. Inclusion criteria were Pashtun or Punjabi ethnicity, intra-ocular pressure < 22 mmHg, gonioscopically open angles, cup-disk-ratio < 0.5, and age matched normal visual fields. Cases with prior ocular surgery, contact lens use, corneal pathologies, myopia or hypermetropia > ±3.0 diopters, astigmatism of > ±1.0 diopters were excluded. Central corneal thickness was measured using a TopCon non-contact specular microscope. Intra-ocular pressure was measured using Goldmann applanation tonometer. Frequency distribution, test of significance, and regression analysis was carried out using Statistical Package for Social Sciences version 20.0. Mean age was 47.31 ±11.78 years. Ethnic composition was 51.6% (n=516) Pashtun and 48.4% (n=484) Punjabi. The mean central corneal thickness was 503.96 (±12.47) µm, while the mean intra-ocular pressure was 15.61 (±2.68) mmHg. Regression analysis showed a significant association between central corneal thickness and intra-ocular pressure (p=0.00) and age (p=0.00). A±100 µchange in central corneal thickness was associated with change in IOPof ±3.30 mmHg, whereas central corneal thickness decreased by 0.12 µm per year. No significant association could be established between central corneal thickness and ethnicity (p=0.19). Central corneal thickness of the studied races was comparable to non-Caucasians which affects intra-ocular pressure measurements, and decreases with increasing age. No relationship was observed between central corneal thickness and ethnicity or gender.

32 CFR 1907.02 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CHALLENGES TO... means the United States Central Intelligence Agency acting through the CIA Information and Privacy... specifically authorized by the Central Intelligence Agency to possess and use on official business classified...

Summary of water-surface-elevation data for 116 U.S. Geological Survey lake and reservoir stations in Texas and comparison to data for water year 2006

USGS Publications Warehouse

Asquith, William H.; Vrabel, Joseph; Roussel, Meghan C.

2007-01-01

The U.S. Geological Survey (USGS), in cooperation with numerous Federal, State, municipal, and local agencies, currently (2007) collects data for more than 120 lakes and reservoirs in Texas through a realtime, data-collection network. The National Water Information System that processes and archives water-resources data for the Nation provides a central source for retrieval of real-time as well as historical data. This report provides a brief description of the real-time, data-collection network and graphically summarizes the period-of-record daily mean water-surface elevations for 116 active and discontinued USGS lake and reservoir stations in Texas. The report also graphically depicts selected statistics (minimum, maximum, and mean) of daily mean water-surface-elevation data. The data for water year 2006 are compared to the selected statistics.

9 CFR 93.423 - Ruminants from Central America and the West Indies.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Ruminants from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Central America and West Indies 9 § 93.423 Ruminants from Central America and the West Indies. (a) Ruminants intended for...

9 CFR 93.423 - Ruminants from Central America and the West Indies.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Ruminants from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Central America and West Indies 9 § 93.423 Ruminants from Central America and the West Indies. (a) Ruminants intended for...

9 CFR 93.423 - Ruminants from Central America and the West Indies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Ruminants from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Central America and West Indies 9 § 93.423 Ruminants from Central America and the West Indies. (a) Ruminants intended for...

9 CFR 93.423 - Ruminants from Central America and the West Indies.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Ruminants from Central America and the... PRODUCTS; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Central America and West Indies 9 § 93.423 Ruminants from Central America and the West Indies. (a) Ruminants intended for...

Impacts of SST Patterns on Rapid Intensification of Typhoon Megi (2010)

NASA Astrophysics Data System (ADS)

Kanada, Sachie; Tsujino, Satoki; Aiki, Hidenori; Yoshioka, Mayumi K.; Miyazawa, Yasumasa; Tsuboki, Kazuhisa; Takayabu, Izuru

2017-12-01

Typhoon Megi (2010), a very intense tropical cyclone with a minimum central pressure of 885 hPa, was characterized by especially rapid intensification. We investigated this intensification process by a simulation experiment using a high-resolution (0.02° × 0.02°) three-dimensional atmosphere-ocean coupled regional model. We also performed a sensitivity experiment with a time-fixed sea surface temperature (SST). The coupled model successfully simulated the minimum central pressure of Typhoon Megi, whereas the fixed SST experiment simulated an excessively low minimum central pressure of 839 hPa. The simulation results also showed a close relationship between the radial SST profiles and the rapid intensification process. Because the warm sea increased near-surface water vapor and hence the convective available potential energy, the high SST in the eye region facilitated tall and intense updrafts inside the radius of maximum wind speed and led to the start of rapid intensification. In contrast, high SST outside this radius induced local secondary updrafts that inhibited rapid intensification even if the mean SST in the core region exceeded 29.0°C. These secondary updrafts moved inward and eventually merged with the primary eyewall updrafts. Then the storm intensified rapidly when the high SST appeared in the eye region. Thus, the changes in the local SST pattern around the storm center strongly affected the rapid intensification process by modulating the radial structure of core convection. Our results also show that the use of a high-resolution three-dimensional atmosphere-ocean coupled model offers promise for improving intensity forecasts of tropical cyclones.

District Central Offices as Learning Organizations: How Sociocultural and Organizational Learning Theories Elaborate District Central Office Administrators' Participation in Teaching and Learning Improvement Efforts

ERIC Educational Resources Information Center

Honig, Meredith I.

2008-01-01

School district central office administrators face unprecedented demands to become key supporters of efforts to improve teaching and learning districtwide. Some suggest that these demands mean that central offices, especially in midsized and large districts, should become learning organizations but provide few guides for how central offices might…

Evaluation of central auditory processing in children with Specific Language Impairment.

PubMed

Włodarczyk, Elżbieta; Szkiełkowska, Agata; Piłka, Adam; Skarżyński, Henryk

2015-01-01

Specific Language Impairment (SLI) affects about 7-15 % of children of school age and according to the currently accepted diagnostic criteria, it is presumed that these children do not suffer from hearing impairment. The goal of this work was to assess anomalies of central auditory processes in a group of children diagnosed with specific language impairment. Material consisted of 200 children aged 7-10 years (100 children in the study group and 100 hundred in the control group). Selected psychoacoustic tests (Frequency Pattern Test - FPT, Duration Pattern Test - DPT, Dichotic Digit Test - DDT, Time Compressed Sentence Test - CST, Gap Detection Test - GDT) were performed in all children. Results were subject to statistical analysis. It was observed that mean results obtained in individual age groups in the study group are significantly lower than in the control group. Based on the conducted studies we may conclude that children with SLI suffer from disorders of some higher auditory functions, which substantiates the diagnosis of hearing disorders according to the AHSA (American Hearing and Speech Association) guidelines. Use of sound-based, not verbal tests, eliminates the probability that observed problems with perception involve only perception of speech, therefore do not signify central hearing disorders, but problems with understanding of speech. Lack of literature data on the significance of FPT, DPT, DDT, CST and GDT tests in children with specific language impairment precludes comparison of acquired results and makes them unique.

Bilateral widespread mechanical pain hypersensitivity as sign of central sensitization in patients with cluster headache.

PubMed

Fernández-de-Las-Peñas, César; Ortega-Santiago, Ricardo; Cuadrado, María L; López-de-Silanes, Carlos; Pareja, Juan A

2011-03-01

To investigate bilateral widespread pressure pain hyperalgesia in deep tissues over symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with cluster headache (CH). Central sensitization is claimed to play a relevant role in CH. No study has previously searched for widespread pressure hyperalgesia in deep tissues over both symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with CH. Sixteen men (mean age: 43 ± 11 years) with CH in a remission phase and 16 matched controls were recruited. Pressure pain thresholds (PPTs) were bilaterally measured over the supra-orbital (V1), infra-orbital (V2), mental (V3), median (C5), radial (C6), and ulnar (C7) nerves, C5-C6 zygapophyseal joint, mastoid process, and tibialis anterior muscle by an assessor blinded to the subjects' condition. The results showed that PPT levels were significantly decreased bilaterally in patients with CH as compared with healthy controls (all sites, P < .001). A greater degree of sensitization over the mastoid process (P < .001) and a lower degree of sensitization over the tibialis anterior muscle (P < .01) was found. Our findings revealed bilateral widespread pressure pain hypersensitivity in patients with CH confirming the presence of central sensitization mechanisms in this headache condition. © 2010 American Headache Society.

Comparison of the Effect of Aliskiren Versus Negative Controls on Aortic Stiffness in Patients With Marfan Syndrome Under Treatment With Atenolol.

PubMed

Hwang, Ji-Won; Kim, Eun Kyoung; Jang, Shin Yi; Chung, Tae-Young; Ki, Chang-Seok; Sung, Kiick; Kim, Sung Mok; Ahn, Joonghyun; Carriere, Keumhee; Choe, Yeon Hyeon; Chang, Sung-A; Kim, Duk-Kyung

2017-11-29

The aim of this study was to evaluate the effect of aliskiren on aortic stiffness in patients with Marfan syndrome (MS). Twenty-eight MS patients (mean age ± standard deviation: 32.6 ± 10.6 years) were recruited from November 2009 to October 2014. All patients were receiving atenolol as standard beta-blocker therapy. A prospective randomization process was performed to assign participants to either aliskiren treatment (150-300mg orally per day) or no aliskiren treatment (negative control) in an open-label design. Central aortic distensibility and central pulsed wave velocity (PWV) by magnetic resonance imaging (MRI), peripheral PWV, central aortic blood pressure and augmentation index by peripheral tonometry, and aortic dilatation by echocardiography were examined initially and after 24 weeks. The primary endpoint was central aortic distensibility by MRI. In analyses of differences between baseline and 24 weeks for the aliskiren treatment group vs the negative control group, central distensibility (overall; P = .26) and central PWV (0.2 ± 0.9 vs 0.03 ± 0.7 [m/s]; P = .79) by MRI were not significantly different. Central systolic aortic blood pressure tended to be lower by 14mmHg in patients in the aliskiren treatment group than in the control group (P = .09). A significant decrease in peripheral PWV (brachial-ankle PWV) in the aliskiren treatment group (-1.6 m/s) compared with the control group (+0.28 m/s) was noted (P = .005). Among patients with MS, the addition of aliskiren to beta-blocker treatment did not significantly improve central aortic stiffness during a 24-week period. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

Grasping Ideas with the Motor System: Semantic Somatotopy in Idiom Comprehension

PubMed Central

Hauk, Olaf; Pulvermüller, Friedemann

2009-01-01

Single words and sentences referring to bodily actions activate the motor cortex. However, this semantic grounding of concrete language does not address the critical question whether the sensory–motor system contributes to the processing of abstract meaning and thought. We examined functional magnetic resonance imaging activation to idioms and literal sentences including arm- and leg-related action words. A common left fronto-temporal network was engaged in sentence reading, with idioms yielding relatively stronger activity in (pre)frontal and middle temporal cortex. Crucially, somatotopic activation along the motor strip, in central and precentral cortex, was elicited by idiomatic and literal sentences, reflecting the body part reference of the words embedded in the sentences. Semantic somatotopy was most pronounced after sentence ending, thus reflecting sentence-level processing rather than that of single words. These results indicate that semantic representations grounded in the sensory–motor system play a role in the composition of sentence-level meaning, even in the case of idioms. PMID:19068489

Disturbed holistic processing in autism spectrum disorders verified by two cognitive tasks requiring perception of complex visual stimuli.

PubMed

Nakahachi, Takayuki; Yamashita, Ko; Iwase, Masao; Ishigami, Wataru; Tanaka, Chitaru; Toyonaga, Koji; Maeda, Shizuyo; Hirotsune, Hideto; Tei, Yosyo; Yokoi, Koichi; Okajima, Shoji; Shimizu, Akira; Takeda, Masatoshi

2008-06-30

Central coherence is a key concept in research on autism spectrum disorders (ASD). It refers to the process in which diverse information is integrated and higher meaning is constructed in context. A malfunction in this process could result in abnormal attention to partial information in preference to the whole. To verify this hypothesis, we studied the performance of two visual tasks by 10 patients with autistic disorder or Asperger's disorder and by 26 (experiment 1) or 25 (experiment 2) normal subjects. In experiment 1, the subjects memorized pictures, some pictures with a change related to the main theme (D1) and others with a change not related to the main theme (D2); then the same pictures were randomly presented to the subjects who were asked to find the change. In experiment 2, the subjects were presented pictures of a normal (N) or a Thatcherized (T) face arranged side by side inversely (I) or uprightly (U) and to judge them as the same or different. In experiment 1, ASD subjects exhibited significantly lower rates of correct responses in D1 but not in D2. In experiment 2, ASD subjects exhibited significantly longer response times in NT-U but not in TN-I. These results showed a deficit in holistic processing, which is consistent with weak central coherence in ASD.

Hospital decentralisation in Romania: stakeholders' perspectives in the newsprint media.

PubMed

Popa, Adela Elena

2014-01-01

In the summer of 2010, Romania undertook a process of hospital decentralisation as part of the reform in the healthcare sector. The national newsprint media covered the process thoroughly. This paper is a study of how key stakeholders' views, attitudes, beliefs and attitudes towards decentralisation are represented in print media. 106 articles, published between June and September 2010, retrieved from the online databases of six leading national dailies were analysed. A mixed methodology was used in the data analysis stage. The qualitative data exploration identified five voices belonging to stakeholders involved directly or indirectly in the process: the representatives of central government, the local authorities (district and local councils, municipal mayors), health professionals (managers and physicians in hospitals), the media (journalists, analysts) and finally voices from civil society, professional associations and advocacy groups. These were the main actors negotiating the subjective meanings of the decentralisation process. An imbalance between these key actors were observed in the frequency, content and tone of the messages delivered in media during the four months. Central government and the local authorities were the most active voices, but the respective discourses differed significantly. An analysis of the accounts identified three main themes: the financial problem (hospitals liabilities and future spending), human resource in hospitals (the impact of decentralisation upon it) and the political character of the decentralisation. Copyright © 2013 John Wiley & Sons, Ltd.

THE STELLAR-TO-HALO MASS RELATION OF LOCAL GALAXIES SEGREGATES BY COLOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodríguez-Puebla, Aldo; Yang, Xiaohu; Foucaud, Sebastien

By means of a statistical approach that combines different semi-empirical methods of galaxy-halo connection, we derive the stellar-to-halo mass relations (SHMR) of local blue and red central galaxies. We also constrain the fraction of halos hosting blue/red central galaxies and the occupation statistics of blue and red satellites as a function of halo mass, M {sub h}. For the observational input we use the blue and red central/satellite galaxy stellar mass functions and two-point correlation functions in the stellar mass range of 9 < log(M {sub *}/M {sub ☉}) <12. We find that: (1) the SHMR of central galaxies is segregated bymore » color, with blue centrals having a SHMR above that of red centrals; at log(M {sub h}/M {sub ☉}) ∼12, the M {sub *}-to-M {sub h} ratio of the blue centrals is ≈0.05, which is ∼1.7 times larger than the value of red centrals. (2) The constrained scatters around the SHMRs of red and blue centrals are ≈0.14 and ≈0.11 dex, respectively. The scatter of the average SHMR of all central galaxies changes from ∼0.20 dex to ∼0.14 dex in the 11.3 < log(M {sub h}/M {sub ☉}) <15 range. (3) The fraction of halos hosting blue centrals at M{sub h}=10{sup 11} M {sub ☉} is 87%, but at 2 × 10{sup 12} M {sub ☉} decays to ∼20%, approaching a few percent at higher masses. The characteristic mass at which this fraction is the same for blue and red galaxies is M{sub h}≈7×10{sup 11} M {sub ☉}. Our results suggest that the SHMR of central galaxies at large masses is shaped by mass quenching. At low masses processes that delay star formation without invoking too strong supernova-driven outflows could explain the high M {sub *}-to-M {sub h} ratios of blue centrals as compared to those of the scarce red centrals.« less

Alternating versus synchronous ventilation of left and right lungs in piglets.

PubMed

Versprille, A; Hrachovina, V; Jansen, J R

1995-12-01

We tested whether alternating ventilation (AV) of each lung (i.e. with a phase difference of half a ventilatory cycle) would decrease central venous pressure and so increase cardiac output when compared with simultaneous ventilation (SV) of both lungs. If, during AV, the inflated lung expands partly via compression of the opposite lung, mean lung volume will be smaller during AV than SV. As a consequence, mean intrathoracic pressure (as cited in the literature), and therefore, central venous pressure will be smaller. The experiments were performed in seven anaesthetized and paralyzed piglets using a double-piston ventilator. Minute ventilation was the same during AV and SV. Starting at SV, we alternated three times between AV and SV for periods of 10 min. During AV, central venous pressure was decreased by 0.7 mmHg and cardiac output was increased by 10 +/- 4.4% (mean, +/-SD) compared with SV. AV also resulted in increased arterial pressure. During one-sided inflation with closed outlet of the opposite lung, a pressure rise occurred in the opposite lung, indicating compression. The higher cardiac output during AV than SV can be explained by the fact that central venous pressure is lower during AV. This lower central venous pressure is very probably due to the lower mean intrathoracic pressure caused by compression of the opposite lung during unilateral inflation.

Central noradrenergic mechanisms and the acute stress response during painful stimulation.

PubMed

Chapman, C Richard; Bradshaw, David H; Donaldson, Gary W; Jacobson, Robert C; Nakamura, Yoshio

2014-12-01

Events that threaten tissue integrity including noxious stimulation activate central noradrenergic circuits, particularly locus coeruleus and its projections. Recent advances in theory hold that an adaptive, defensive shift in brain activity takes place in response to threat. In principle, this shift may accentuate the autonomic and central biomarkers of the perception of painful events and the experience of pain itself. We have examined the effects of an alpha-2 agonist on pupil dilation responses, skin conductance responses, near field somatosensory evoked potentials and pain reports in normal volunteers undergoing repeated trials of painful fingertip stimulation delivered at low, medium and high intensities. In a double-blinded study, 114 healthy male and female volunteers underwent repeated noxious stimulation under baseline, placebo and active drug conditions where the active drug was the alpha-2 agonist tizanidine 4 mg. In contrast to baseline and placebo conditions, tizanidine 4 mg significantly reduced the magnitudes of the mean pupil dilation response, the mean skin conductance response, the mean near field somatosensory evoked potential peak-to-peak amplitude and the mean pain intensity rating. Stimulus intensity significantly altered all three biomarkers and the pain report in a graded fashion. There were no sex differences. These findings support the hypotheses that painful events activate central noradrenergic circuits, and that these circuits play a role in the autonomic and central arousal associated with pain. © The Author(s) 2014.

SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM

PubMed Central

Nogueiras, Ruben; Habegger, Kirk M.; Chaudhary, Nilika; Finan, Brian; Banks, Alexander S.; Dietrich, Marcelo O.; Horvath, Tamas L.; Sinclair, David A.; Pfluger, Paul T.; Tschöop, Matthias H.

2013-01-01

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD+ levels, a condition caused by low cellular energy status. By deacetylating a variety of proteins that induce catabolic processes while inhibiting anabolic processes, SIRT1 and SIRT3 coordinately increase cellular energy stores and ultimately maintain cellular energy homeostasis. Defects in the pathways controlled by SIRT1 and SIRT3 are known to result in various metabolic disorders. Consequently, activation of sirtuins by genetic or pharmacological means can elicit multiple metabolic benefits that protect mice from diet-induced obesity, type 2 diabetes, and nonalcoholic fatty liver disease. PMID:22811431

Oscillometric estimation of central blood pressure: validation of the Mobil-O-Graph in comparison with the SphygmoCor device.

PubMed

Weiss, Wolfgang; Gohlisch, Christopher; Harsch-Gladisch, Christl; Tölle, Markus; Zidek, Walter; van der Giet, Markus

2012-06-01

Hypertension is a major risk factor for a wide range of cardiovascular diseases and is typically identified by measuring blood pressure (BP) at the brachial artery. Although such a measurement may accurately determine diastolic BP, systolic BP is not reflected accurately. Current noninvasive techniques for assessing central aortic BP require additional recording of an arterial pressure wave using a high-fidelity applanation tonometer. Within one measurement cycle, the Mobil-O-Graph BP device uses brachial oscillometric BP waves for a noninvasive estimation of central BP. We therefore validated the Mobil-O-Graph against the SphygmoCor device, which is widely known as the commonly used approach for a noninvasive estimation of central BP. For each individual, we compared three readings of the central BP values obtained by the Mobil-O-Graph and SphygmoCor device consecutively. One hundred individuals (mean age 56.1 ± 15.4 years) were recruited for measurement.Differences between the central BP values of the test device and the SphygmoCor device were calculated for each measurement. The mean difference (95% confidence interval) for the estimated central systolic BP between both devices was -0.6 ± 3.7 mmHg. Comparison of the central BP values measured by the two devices showed a statistically significant linear correlation (R=0.91, P<0.0001). The mean between-method difference was 0.50 mmHg for central systolic BP estimation. The intrarater reproducibility between both the devices was also comparable. Bland and Altman analyses showed that the mean differences (95% confidence interval) between repeated measurements were 1.89 (0.42-3.36) mmHg and 1.36 (-0.16 to 2.83) mmHg for the SphygmoCor and the Mobil-O-Graph device, respectively. Thus, neither of these differences was statistically significantly different from 0. The limits of agreement were -16.34 to 19.73 and -15.23 to 17.17 mmHg for the SphygmoCor and the Mobil-O-Graph device, respectively. Oscillometric noninvasive estimation of central BP with the Mobil-O-Graph BP device is as effective as using the well-established SphygmoCor applanation tonometry device. In comparison, the Mobil-O-Graph combines the widespread benefits of brachial BP measurement and also provides central BP within one measurement.

Recognition of oral spelling is diagnostic of the central reading processes.

PubMed

Schubert, Teresa; McCloskey, Michael

2015-01-01

The task of recognition of oral spelling (stimulus: "C-A-T", response: "cat") is often administered to individuals with acquired written language disorders, yet there is no consensus about the underlying cognitive processes. We adjudicate between two existing hypotheses: Recognition of oral spelling uses central reading processes, or recognition of oral spelling uses central spelling processes in reverse. We tested the recognition of oral spelling and spelling to dictation abilities of a single individual with acquired dyslexia and dysgraphia. She was impaired relative to matched controls in spelling to dictation but unimpaired in recognition of oral spelling. Recognition of oral spelling for exception words (e.g., colonel) and pronounceable nonwords (e.g., larth) was intact. Our results were predicted by the hypothesis that recognition of oral spelling involves the central reading processes. We conclude that recognition of oral spelling is a useful tool for probing the integrity of the central reading processes.

Disgust evoked by strong wormwood bitterness influences the processing of visual food cues in women: An ERP study.

PubMed

Schwab, Daniela; Giraldo, Matteo; Spiegl, Benjamin; Schienle, Anne

2017-01-01

The perception of intense bitterness is associated with disgust and food rejection. The present cross-modal event-related potential (ERP) study investigated whether a bitter aftertaste is able to influence affective ratings and the neuronal processing of visual food cues. We presented 39 healthy normal-weight women (mean age: 22.5 years) with images depicting high-caloric meat dishes, high-caloric sweets, and low-caloric vegetables after they had either rinsed their mouth with wormwood tea (bitter group; n = 20) or water (control group; n = 19) for 30s. The bitter aftertaste of wormwood enhanced fronto-central early potentials (N100, N200) and reduced P300 amplitudes for all food types (meat, sweets, vegetables). Moreover, meat and sweets elicited higher fronto-central LPPs than vegetables in the water group. This differentiation was absent in the bitter group, which gave lower arousal ratings for the high-caloric food. We found that a minor intervention ('bitter rinse') was sufficient to induce changes in the neuronal processing of food images reflecting increased early attention (N100, N200) as well as reduced affective value (P300, LPP). Future studies should investigate whether this intervention is able to influence eating behavior. Copyright © 2016 Elsevier Ltd. All rights reserved.

Late 20th Century benthic foraminiferal distribution in Central San Francisco Bay, California: Influence of the Trochammina hadai invasion

USGS Publications Warehouse

McGann, Mary L.

2014-01-01

Samples collected from 1965 onward were also compared with those from 1998 to investigate how the distribution of benthic foraminifera in Central Bay has changed over the latter half of the 20th Century, particularly in response to the invasion by Trochammina hadai. In 1998, T. hadai was recovered at 46 of 55 sites in Central Bay, comprising from 0.3 to 97% (mean = 23%) of the foraminiferal fauna. With the species’ affiliation for shallow environments, it is not unexpected that it dominated the fauna of the Shallow Subtidal Biofacies (68-97%, mean = 77%) and was also a significant component of the Intermediate Subtidal Biofacies (7-51%, averaging 28%). In the deeper waters west of Alcatraz Island, the abundance of T. hadai was significantly less (mean = 8%), most likely reflecting allochthonous specimens that were the result of post-mortem transport. A cluster analysis clearly distinguishes pre- and post-invasion biofacies, illustrating how dominant T. hadai has become in Central Bay.

Central Body Fat Distribution Associates with Unfavorable Renal Hemodynamics Independent of Body Mass Index

PubMed Central

Zelle, Dorien M.; Bakker, Stephan J.L.; Navis, Gerjan

2013-01-01

Central distribution of body fat is associated with a higher risk of renal disease, but whether it is the distribution pattern or the overall excess weight that underlies this association is not well understood. Here, we studied the association between waist-to-hip ratio (WHR), which reflects central adiposity, and renal hemodynamics in 315 healthy persons with a mean body mass index (BMI) of 24.9 kg/m2 and a mean 125I-iothalamate GFR of 109 ml/min per 1.73 m2. In multivariate analyses, WHR was associated with lower GFR, lower effective renal plasma flow, and higher filtration fraction, even after adjustment for sex, age, mean arterial pressure, and BMI. Multivariate models produced similar results regardless of whether the hemodynamic measures were indexed to body surface area. Thus, these results suggest that central body fat distribution, independent of BMI, is associated with an unfavorable pattern of renal hemodynamic measures that could underlie the increased renal risk reported in observational studies. PMID:23578944

A Simple Criterion to Estimate Performance of Pulse Jet Mixed Vessels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pease, Leonard F.; Bamberger, Judith A.; Mahoney, Lenna A.

Pulse jet mixed process vessels comprise a key element of the U.S. Department of Energy’s strategy to process millions of gallons of legacy nuclear waste slurries. Slurry suctioned into a pulse jet mixer (PJM) tube at the end of one pulse is pneumatically driven from the PJM toward the bottom of the vessel at the beginning of the next pulse, forming a jet. The jet front traverses the distance from nozzle outlet to the bottom of the vessel and spreads out radially. Varying numbers of PJMs are typically arranged in a ring configuration within the vessel at a selected radiusmore » and operated concurrently. Centrally directed radial flows from neighboring jets collide to create a central upwell that elevates the solids in the center of the vessel when the PJM tubes expel their contents. An essential goal of PJM operation is to elevate solids to the liquid surface to minimize stratification. Solids stratification may adversely affect throughput of the waste processing plant. Unacceptably high slurry densities at the base of the vessel may plug the pipeline through which the slurry exits the vessel. Additionally, chemical reactions required for processing may not achieve complete conversion. To avoid these conditions, a means of predicting the elevation to which the solids rise in the central upwell that can be used during vessel design remains essential. In this paper we present a simple criterion to evaluate the extent of solids elevation achieved by a turbulent upwell jet. The criterion asserts that at any location in the central upwell the local velocity must be in excess of a cutoff velocity to remain turbulent. We find that local velocities in excess of 0.6 m/s are necessary for turbulent jet flow through both Newtonian and yield stress slurries. By coupling this criterion with the free jet velocity equation relating the local velocity to elevation in the central upwell, we estimate the elevation at which turbulence fails, and consequently the elevation at which the upwell fails to further lift the slurry. Comparing this elevation to the vessel fill level predicts whether the jet flow will achieve the full vertical extent of the vessel at the center. This simple local-velocity criterion determines a minimum PJM nozzle velocity at which the full vertical extent of the central upwell in PJM vessels will be turbulent. The criterion determines a minimum because flow in regions peripheral to the central upwelling jet may not be turbulent, even when the center of the vessel in the upwell is turbulent, if the jet pulse duration is too short. The local-velocity criterion ensures only that there is sufficient wherewithal for the turbulent jet flow to drive solids to the surface in the center of the vessel in the central upwell.« less

Reading Comprehension in Children with ADHD: Cognitive Underpinnings of the Centrality Deficit

ERIC Educational Resources Information Center

Miller, Amanda C.; Keenan, Janice M.; Betjemann, Rebecca S.; Willcutt, Erik G.; Pennington, Bruce F.; Olson, Richard K.

2013-01-01

We examined reading comprehension in children with ADHD by assessing their ability to build a coherent mental representation that allows them to recall central and peripheral information. We compared children with ADHD (mean age 9.78) to word reading-matched controls (mean age 9.89) on their ability to retell a passage. We found that even though…

Classroom Research: Assessment of Student Understanding of Sampling Distributions of Means and the Central Limit Theorem in Post-Calculus Probability and Statistics Classes

ERIC Educational Resources Information Center

Lunsford, M. Leigh; Rowell, Ginger Holmes; Goodson-Espy, Tracy

2006-01-01

We applied a classroom research model to investigate student understanding of sampling distributions of sample means and the Central Limit Theorem in post-calculus introductory probability and statistics courses. Using a quantitative assessment tool developed by previous researchers and a qualitative assessment tool developed by the authors, we…

From ketenimines to ketenes to quinolones: two consecutive pseudopericyclic events.

PubMed

Alajarín, Mateo; Ortín, María-Mar; Sánchez-Andrada, Pilar; Vidal, Angel; Bautista, Delia

2005-11-10

[reaction: see text] N-[2-(Alkyl- or arylthio)carbonyl]phenyl ketenimines undergo cyclization under mild thermal conditions to afford 2-alkyl(aryl)thio-3H-quinolin-4-ones by means of the 1,5-migration of the alkyl(aryl)thio group from the carbonyl carbon to the central carbon atom of the ketenimine fragment followed by the 6pi-electrocyclization of the resulting vinyliminoketene. These 1,5-migration and electrocyclization processes occur via transition states whose pseudopericyclic characteristics have been established on the basis of their magnetic properties, geometries, and NBO analyses.

Concept of Integrated Information Systems of Rail Transport

NASA Astrophysics Data System (ADS)

Siergiejczyk, Mirosław; Gago, Stanisław

This paper will present a need to create integrated information systems of the rail transport and their links with other means of public transportation. IT standards will be discussed that are expected to create the integrated information systems of the rail transport. Also the main tasks will be presented of centralized information systems, the concept of their architecture, business processes and their implementation as well as the proposed measures to secure data. A method shall be proposed to implement a system to inform participants of rail transport in Polish conditions.

Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: An immunohistochemical analysis.

PubMed

Vk, Varsha; Hallikeri, Kaveri; Girish, H C; Murgod, Sanjay

2014-01-01

Central and Peripheral giant cell granulomas of jaws are uncommon, benign, reactive disorders that are characterized by the presence of numerous multinucleated giant cells and mononuclear cells within a stroma. The origin of the multinucleated giant cells is controversial; probably originating from fusion of histiocytes, endothelial cells and fibroblasts. To assess the expression of CD34 and CD68 in central and peripheral giant cell granulomas to understand the origin of these multinucleated giant cells. Twenty cases of Central and Peripheral giant cell granulomas were evaluated immunohistochemically for CD34 and CD68 proteins expression. Immunopositivity for CD34 was seen only in cytoplasm of endothelial cells of blood vessels; whereas, consistent cytoplasmic immunopositivity for CD68 was seen in few stromal cells. Statistical significance was seen in mean number of multinucleated giant cells, mean number of nuclei in multinucleated giant cells, CD68 expression and ratio of macrophages to multinucleated giant cells among two lesions. Although the central giant cell granulomas share some clinical and histopathological similarities with peripheral giant cell granulomas, differences in mean number of nuclei in multinucleated giant cells and CD68 immunoreactivity may underlie the distinct clinical behavior.

Comparison of Centralized-Manual, Centralized-Computerized, and Decentralized-Computerized Order and Management Information Models for the Turkish Air Force Logistics System.

DTIC Science & Technology

1986-09-01

differentiation between the systems. This study will investigate an appropriate Order Processing and Management Information System (OP&MIS) to link base-level...methodology: 1. Reviewed the current order processing and information model of the TUAF Logistics System. (centralized-manual model) 2. Described the...RDS program’s order processing and information system. (centralized-computerized model) 3. Described the order irocessing and information system of

Microsatellite data suggest significant population structure and differentiation within the malaria vector Anopheles darlingi in Central and South America.

PubMed

Mirabello, Lisa; Vineis, Joseph H; Yanoviak, Stephen P; Scarpassa, Vera M; Póvoa, Marinete M; Padilla, Norma; Achee, Nicole L; Conn, Jan E

2008-03-26

Anopheles darlingi is the most important malaria vector in the Neotropics. An understanding of A. darlingi's population structure and contemporary gene flow patterns is necessary if vector populations are to be successfully controlled. We assessed population genetic structure and levels of differentiation based on 1,376 samples from 31 localities throughout the Peruvian and Brazilian Amazon and Central America using 5-8 microsatellite loci. We found high levels of polymorphism for all of the Amazonian populations (mean RS = 7.62, mean HO = 0.742), and low levels for the Belize and Guatemalan populations (mean RS = 4.3, mean HO = 0.457). The Bayesian clustering analysis revealed five population clusters: northeastern Amazonian Brazil, southeastern and central Amazonian Brazil, western and central Amazonian Brazil, Peruvian Amazon, and the Central American populations. Within Central America there was low non-significant differentiation, except for between the populations separated by the Maya Mountains. Within Amazonia there was a moderate level of significant differentiation attributed to isolation by distance. Within Peru there was no significant population structure and low differentiation, and some evidence of a population expansion. The pairwise estimates of genetic differentiation between Central America and Amazonian populations were all very high and highly significant (FST = 0.1859 - 0.3901, P < 0.05). Both the DA and FST distance-based trees illustrated the main division to be between Central America and Amazonia. We detected a large amount of population structure in Amazonia, with three population clusters within Brazil and one including the Peru populations. The considerable differences in Ne among the populations may have contributed to the observed genetic differentiation. All of the data suggest that the primary division within A. darlingi corresponds to two white gene genotypes between Amazonia (genotype 1) and Central America, parts of Colombia and Venezuela (genotype 2), and are in agreement with previously published mitochondrial COI gene sequences interpreted as incipient species. Overall, it appears that two main factors have contributed to the genetic differentiation between the population clusters: physical distance between the populations and the differences in effective population sizes among the subpopulations.

Specialized operating room for cesarean section in the perinatal care unit: a review of the opening process and operating room management.

PubMed

Kasagi, Yoshihiro; Okutani, Ryu; Oda, Yutaka

2015-02-01

We have opened an operating room in the perinatal care unit (PNCU), separate from our existing central operating rooms, to be used exclusively for cesarean sections. The purpose is to meet the increasing need for both emergency cesarean sections and non-obstetric surgeries. It is equipped with the same surgical instruments, anesthesia machine, monitoring system, rapid infusion system and airway devices as the central operating rooms. An anesthesiologist and a nurse from the central operating rooms trained the nurses working in the new operating room, and discussed solutions to numerous problems that arose before and after its opening. Currently most of the elective and emergency cesarean sections carried out during the daytime on weekdays are performed in the PNCU operating room. A total of 328 and 347 cesarean sections were performed in our hospital during 2011 and 2012, respectively, of which 192 (55.5 %) and 254 (73.2 %) were performed in the PNCU operating room. The mean occupancy rate of the central operating rooms also increased from 81 % in 2011 to 90 % in 2012. The PNCU operating room was built with the support of motivated personnel and multidisciplinary teamwork, and has been found to be beneficial for both surgeons and anesthesiologists, while it also contributes to hospital revenue.

FUNDUS AUTOFLUORESCENCE LIFETIMES AND CENTRAL SEROUS CHORIORETINOPATHY.

PubMed

Dysli, Chantal; Berger, Lieselotte; Wolf, Sebastian; Zinkernagel, Martin S

2017-11-01

To quantify retinal fluorescence lifetimes in patients with central serous chorioretinopathy (CSC) and to identify disease specific lifetime characteristics over the course of disease. Forty-seven participants were included in this study. Patients with central serous chorioretinopathy were imaged with fundus photography, fundus autofluorescence, optical coherence tomography, and fluorescence lifetime imaging ophthalmoscopy (FLIO) and compared with age-matched controls. Retinal autofluorescence was excited using a 473-nm blue laser light and emitted fluorescence light was detected in 2 distinct wavelengths channels (498-560 nm and 560-720 nm). Clinical features, mean retinal autofluorescence lifetimes, autofluorescence intensity, and corresponding optical coherence tomography (OCT) images were further analyzed. Thirty-five central serous chorioretinopathy patients with a mean visual acuity of 78 ETDRS letters (range, 50-90; mean Snellen equivalent: 20/32) and 12 age-matched controls were included. In the acute stage of central serous chorioretinopathy, retinal fluorescence lifetimes were shortened by 15% and 17% in the respective wavelength channels. Multiple linear regression analysis showed that fluorescence lifetimes were significantly influenced by the disease duration (P < 0.001) and accumulation of photoreceptor outer segments (P = 0.03) but independent of the presence or absence of subretinal fluid. Prolonged central macular autofluorescence lifetimes, particularly in eyes with retinal pigment epithelial atrophy, were associated with poor visual acuity. This study establishes that autofluorescence lifetime changes occurring in central serous chorioretinopathy exhibit explicit patterns which can be used to estimate perturbations of the outer retinal layers with a high degree of statistical significance.

New levels of language processing complexity and organization revealed by granger causation.

PubMed

Gow, David W; Caplan, David N

2012-01-01

Granger causation analysis of high spatiotemporal resolution reconstructions of brain activation offers a new window on the dynamic interactions between brain areas that support language processing. Premised on the observation that causes both precede and uniquely predict their effects, this approach provides an intuitive, model-free means of identifying directed causal interactions in the brain. It requires the analysis of all non-redundant potentially interacting signals, and has shown that even "early" processes such as speech perception involve interactions of many areas in a strikingly large network that extends well beyond traditional left hemisphere perisylvian cortex that play out over hundreds of milliseconds. In this paper we describe this technique and review several general findings that reframe the way we think about language processing and brain function in general. These include the extent and complexity of language processing networks, the central role of interactive processing dynamics, the role of processing hubs where the input from many distinct brain regions are integrated, and the degree to which task requirements and stimulus properties influence processing dynamics and inform our understanding of "language-specific" localized processes.

Adaptive memory: enhanced location memory after survival processing.

PubMed

Nairne, James S; Vanarsdall, Joshua E; Pandeirada, Josefa N S; Blunt, Janell R

2012-03-01

Two experiments investigated whether survival processing enhances memory for location. From an adaptive perspective, remembering that food has been located in a particular area, or that potential predators are likely to be found in a given territory, should increase the chances of subsequent survival. Participants were shown pictures of food or animals located at various positions on a computer screen. The task was to rate the ease of collecting the food or capturing the animals relative to a central fixation point. Surprise retention tests revealed that people remembered the locations of the items better when the collection or capturing task was described as relevant to survival. These data extend the generality of survival processing advantages to a new domain (location memory) by means of a task that does not involve rating the relevance of words to a scenario. 2012 APA, all rights reserved

Exploring the Power Output of Small Wind Turbines in Urban San Antonio, Texas

NASA Astrophysics Data System (ADS)

Casillas, Jose; Sperduti, Stephanie; Cardenas, Rosa

2015-03-01

The means of transporting power from a centralized power plant by transmission lines has several disadvantages. Electricity transmission and distribution networks are costly, require long planning processes and are unsightly to residents. These networks are also susceptible to natural disasters creating massive disruptions to consumers. For these reasons distributed power sources such as solar panels and small wind turbines are becoming a more desirable and viable means of energy production. We report on the status of a study to determine the maximum output power of small wind turbines in urban San Antonio, Texas. Wind speed data along with power measurements from small wind turbines in urban San Antonio will be reported. U.S. Department of Education Title V HSI-STEM and Articulation Award No. P031C110145.

Potential effects of climate change on streamflow for seven watersheds in eastern and central Montana

USGS Publications Warehouse

Chase, Katherine J.; Haj, Adel E.; Regan, R. Steven; Viger, Roland J.

2016-01-01

Study regionEastern and central Montana.Study focusFish in Northern Great Plains streams tolerate extreme conditions including heat, cold, floods, and drought; however changes in streamflow associated with long-term climate change may render some prairie streams uninhabitable for current fish species. To better understand future hydrology of these prairie streams, the Precipitation-Runoff Modeling System model and output from the RegCM3 Regional Climate model were used to simulate streamflow for seven watersheds in eastern and central Montana, for a baseline period (water years 1982–1999) and three future periods: water years 2021–2038 (2030 period), 2046–2063 (2055 period), and 2071–2088 (2080 period).New hydrological insights for the regionProjected changes in mean annual and mean monthly streamflow vary by the RegCM3 model selected, by watershed, and by future period. Mean annual streamflows for all future periods are projected to increase (11–21%) for two of the four central Montana watersheds: Middle Musselshell River and Cottonwood Creek. Mean annual streamflows for all future periods are projected to decrease (changes of −24 to −75%) for Redwater River watershed in eastern Montana. Mean annual streamflows are projected to increase slightly (2–15%) for the 2030 period and decrease (changes of −16 to −44%) for the 2080 period for the four remaining watersheds.

Discursive Deployments: Mobilizing Support for Municipal and Community Wireless Networks in the U.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alvarez, Rosio; Rodriguez, Juana Maria

2008-08-16

This paper examines Municipal Wireless (MW) deployments in the United States. In particular, the interest is in understanding how discourse has worked to mobilize widespread support for MW networks. We explore how local governments discursively deploy the language of social movements to create a shared understanding of the networking needs of communities. Through the process of"framing" local governments assign meaning to the MW networks in ways intended to mobilize support anddemobilize opposition. The mobilizing potential of a frame varies and is dependent on its centrality and cultural resonance. We examine the framing efforts of MW networks by using a samplemore » of Request for Proposals for community wireless networks, semi-structured interviews and local media sources. Prominent values that are central to a majority of the projects and others that are culturally specific are identified and analyzed for their mobilizing potency.« less

Electrical stimulation as a means for achieving recovery of function in stroke patients.

PubMed

Popović, Dejan B; Sinkaer, Thomas; Popović, Mirjana B

2009-01-01

This review presents technologies used in and assesses the main clinical outcomes of electrical therapies designed to speed up and increase functional recovery in stroke patients. The review describes methods which interface peripheral systems (e.g., cyclic neural stimulation, stimulation triggered by electrical activity of muscles, therapeutic functional electrical stimulation) and transcranial brain stimulation with surface and implantable electrodes. Our conclusion from reviewing these data is that integration of electrical therapy into exercise-active movement mediated by electrical activation of peripheral and central sensory-motor mechanisms enhances motor re-learning following damage to the central nervous system. Motor re-learning is considered here as a set of processes associated with practice or experience that leads to long-term changes in the capability for movement. An important suggestion is that therapeutic effects are likely to be much more effective when treatment is applied in the acute, rather than in the chronic, phase of stroke.

The influence of (central) auditory processing disorder in speech sound disorders.

PubMed

Barrozo, Tatiane Faria; Pagan-Neves, Luciana de Oliveira; Vilela, Nadia; Carvallo, Renata Mota Mamede; Wertzner, Haydée Fiszbein

2016-01-01

Considering the importance of auditory information for the acquisition and organization of phonological rules, the assessment of (central) auditory processing contributes to both the diagnosis and targeting of speech therapy in children with speech sound disorders. To study phonological measures and (central) auditory processing of children with speech sound disorder. Clinical and experimental study, with 21 subjects with speech sound disorder aged between 7.0 and 9.11 years, divided into two groups according to their (central) auditory processing disorder. The assessment comprised tests of phonology, speech inconsistency, and metalinguistic abilities. The group with (central) auditory processing disorder demonstrated greater severity of speech sound disorder. The cutoff value obtained for the process density index was the one that best characterized the occurrence of phonological processes for children above 7 years of age. The comparison among the tests evaluated between the two groups showed differences in some phonological and metalinguistic abilities. Children with an index value above 0.54 demonstrated strong tendencies towards presenting a (central) auditory processing disorder, and this measure was effective to indicate the need for evaluation in children with speech sound disorder. Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

[Children with specific language impairment: electrophysiological and pedaudiological findings].

PubMed

Rinker, T; Hartmann, K; Smith, E; Reiter, R; Alku, P; Kiefer, M; Brosch, S

2014-08-01

Auditory deficits may be at the core of the language delay in children with Specific Language Impairment (SLI). It was therefore hypothesized that children with SLI perform poorly on 4 tests typically used to diagnose central auditory processing disorder (CAPD) as well in the processing of phonetic and tone stimuli in an electrophysiological experiment. 14 children with SLI (mean age 61,7 months) and 16 children without SLI (mean age 64,9 months) were tested with 4 tasks: non-word repetition, language discrimination in noise, directional hearing, and dichotic listening. The electrophysiological recording Mismatch Negativity (MMN) employed sine tones (600 vs. 650 Hz) and phonetic stimuli (/ε/ versus /e/). Control children and children with SLI differed significantly in the non-word repetition as well as in the dichotic listening task but not in the two other tasks. Only the control children recognized the frequency difference in the MMN-experiment. The phonetic difference was discriminated by both groups, however, effects were longer lasting for the control children. Group differences were not significant. Children with SLI show limitations in auditory processing that involve either a complex task repeating unfamiliar or difficult material and show subtle deficits in auditory processing at the neural level. © Georg Thieme Verlag KG Stuttgart · New York.

Pre-analytical phase: The automated ProTube device supports quality assurance in the phlebotomy process.

PubMed

Piva, Elisa; Tosato, Francesca; Plebani, Mario

2015-12-07

Most errors in laboratory medicine occur in the pre-analytical phase of the total testing process. Phlebotomy, a crucial step in the pre-analytical phase influencing laboratory results and patient outcome, calls for quality assurance procedures and automation in order to prevent errors and ensure patient safety. We compared the performance of a new small, automated device, the ProTube Inpeco, designed for use in phlebotomy with a complete traceability of the process, with a centralized automated system, BC ROBO. ProTube was used for 15,010 patients undergoing phlebotomy with 48,776 tubes being labeled. The mean time and standard deviation (SD) for blood sampling was 3:03 (min:sec; SD ± 1:24) when using ProTube, against 5:40 (min:sec; SD ± 1:57) when using BC ROBO. The mean number of patients per hour managed at each phlebotomy point was 16 ± 3 with ProTube, and 10 ± 2 with BC ROBO. No tubes were labeled erroneously or incorrectly, even if process failure occurred in 2.8% of cases when ProTube was used. Thanks to its cutting edge technology, the ProTube has many advantages over BC ROBO, above all in verifying patient identity, and in allowing a reduction in both identification error and tube mislabeling.

A Microsoft® Excel Simulation Illustrating the Central Limit Theorem's Appropriateness for Comparing the Difference between the Means of Any Two Populations

ERIC Educational Resources Information Center

Moen, David H.; Powell, John E.

2008-01-01

Using Microsoft® Excel, several interactive, computerized learning modules are developed to illustrate the Central Limit Theorem's appropriateness for comparing the difference between the means of any two populations. These modules are used in the classroom to enhance the comprehension of this theorem as well as the concepts that provide the…

Enabling Students to Understand Measures of Central Tendency and Variation

ERIC Educational Resources Information Center

Suco, Erika; Samere, Marie; Hong, Siu Lun

2012-01-01

Somewhere in a programme of study for mathematics in Key Stages 3 and 4 you would expect to find the terms mean, mode, median, and range. You might even find the terms central tendency, and variation. Many students following such a programme will be able to calculate the mean, most will be able to quote the mode, and some students will be able to…

Working Memory in Children With Neurocognitive Effects From Sickle Cell Disease: Contributions of the Central Executive and Processing Speed

PubMed Central

Smith, Kelsey E.; Schatz, Jeffrey

2017-01-01

Children with sickle cell disease (SCD) are at risk for working memory deficits due to multiple disease processes. We assessed working memory abilities and related functions in 32 school-age children with SCD and 85 matched comparison children using Baddeley’s working memory model as a framework. Children with SCD performed worse than controls for working memory, central executive function, and processing/rehearsal speed. Central executive function was found to mediate the relationship between SCD status and working memory, but processing speed did not. Cognitive remediation strategies that focus on central executive processes may be important for remediating working memory deficits in SCD. PMID:27759435

On the parameters influencing air-water gas exchange

NASA Astrophysics Data System (ADS)

JäHne, Bernd; Münnich, Karl Otto; BöSinger, Rainer; Dutzi, Alfred; Huber, Werner; Libner, Peter

1987-02-01

Detailed gas exchange measurements from two circular and one linear wind/wave tunnels are presented. Heat, He, CH4, CO2, Kr, and Xe have been used as tracers. The experiments show the central importance of waves for the water-side transfer process. With the onset of waves the Schmidt number dependence of the transfer velocity k changes from k ∝ Sc-⅔ to k ∝ Sc-½indicating a change in the boundary conditions at the surface. Moreover, energy put into the wave field by wind is transferred to near-surface turbulence enhancing gas transfer. The data show that the mean square slope of the waves is the best parameter to characterize the free wavy surface with respect to water-side transfer processes.

Assessment Study on Sensors and Automation in the Industries of the Future. Reports on Industrial Controls, Information Processing, Automation, and Robotics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Bonnie; Boddy, Mark; Doyle, Frank

This report presents the results of an expert study to identify research opportunities for Sensors & Automation, a sub-program of the U.S. Department of Energy (DOE) Industrial Technologies Program (ITP). The research opportunities are prioritized by realizable energy savings. The study encompasses the technology areas of industrial controls, information processing, automation, and robotics. These areas have been central areas of focus of many Industries of the Future (IOF) technology roadmaps. This report identifies opportunities for energy savings as a direct result of advances in these areas and also recognizes indirect means of achieving energy savings, such as product quality improvement,more » productivity improvement, and reduction of recycle.« less

Nursing communication in nursing care to mastectomized women: a grounded theory study.

PubMed

de Almeida Araújo, Iliana Maria; da Silva, Raimunda Magalhães; Bonfim, Isabela Melo; Fernandes, Ana Fátima Carvalho

2010-01-01

The goal was to understand the nurse/patient communication process, emphasizing nursing care to mastectomized women. Symbolic Interactionism and Grounded Theory were used to interview eight nurses from a referral institution in cancer treatment, using the guiding question: how do nurses perceive their communication process with mastectomized women? Data analysis allowed for the creation of a central theory: the meaning of communication in nursing care to women, constituted by three distinct but inter-related phenomena: perceiving communication, the relationship nurse/mastectomized woman and rethinking the communication nurse/mastectomized woman. With a view to satisfactory communication, professionals need to get involved and believe that their presence is as important as the performance of technical procedures that relieve situations of stress.

Aerosol Chemical and Physical Characterization in Central Amazonia during the 2013 Dry Season

NASA Astrophysics Data System (ADS)

Artaxo, P.; Stern, R.; Brito, J.; Carbone, S.

2015-12-01

During the dry season, the central Amazon forest is highly influenced by forest fires transported through large distances, changing drastically the atmospheric composition even in remote places. This work focuses on a physical-chemical characterization of the aerosol population over a pristine site in Central Amazonia during the dry season. The submicrometer organic aerosols were measured with the Aerodyne ACSM (Aerosol Chemical Speciation Monitor, Aerodyne Inc). Optical properties, size distribution and other micro-physical characteristics were also analyzed. Other instruments were simultaneously used. The measurements were taken during the dry season of 2013 in the Cuieiras ecological reserve (ZF2), northwest of Manaus. The statistical analysis of the data was done with the PMF (Positive Matrix Factorization) technique, in which the organic aerosol was separated into different factors, and then its sources and forming processes were attributed. Results show that the mean aerosol loading was 5,91 μg m-3, from which 78% are of organic composition, 8.5% are sulfate, 6.5% are equivalent black carbon, 4% are ammonium and 3% are nitrate. The mass spectra variability can be explained by 3 factors only, determined with the PMF technique. They were identified as BBOA (Biomass Burning Organic Aerosol), representing 12% of the total organic mass, OOA (Oxygenated Organic Aerosol), representing 66% of the total organic mass and IEPOX-SOA (Isoprene derived Epoxydiol-Secondary Organic Aerosol), representing 21% of the total organic mass. Even in remote and pristine regions, Central Amazonia is highly impacted by biomass burning. Biogenic secondary organic aerosols are also present during the dry season, and the suppression of its wet deposition processes increases their concentration. The oxidation level and other physical-chemical characteristics indicate that the long range transport is responsible for the regional range of this impact.

QUENCHING OF STAR FORMATION IN SLOAN DIGITAL SKY SURVEY GROUPS: CENTRALS, SATELLITES, AND GALACTIC CONFORMITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knobel, Christian; Lilly, Simon J.; Woo, Joanna

2015-02-10

We re-examine the fraction of low-redshift Sloan Digital Sky Survey satellites and centrals in which star formation has been quenched, using the environment quenching efficiency formalism that separates out the dependence of stellar mass. We show that the centrals of the groups containing the satellites are responding to the environment in the same way as their satellites (at least for stellar masses above 10{sup 10.3} M {sub ☉}), and that the well-known differences between satellites and the general set of centrals arise because the latter are overwhelmingly dominated by isolated galaxies. The widespread concept of ''satellite quenching'' as the causemore » of environmental effects in the galaxy population can therefore be generalized to ''group quenching''. We then explore the dependence of the quenching efficiency of satellites on overdensity, group-centric distance, halo mass, the stellar mass of the satellite, and the stellar mass and specific star formation rate (sSFR) of its central, trying to isolate the effect of these often interdependent variables. We emphasize the importance of the central sSFR in the quenching efficiency of the associated satellites, and develop the meaning of this ''galactic conformity'' effect in a probabilistic description of the quenching of galaxies. We show that conformity is strong, and that it varies strongly across parameter space. Several arguments then suggest that environmental quenching and mass quenching may be different manifestations of the same underlying process. The marked difference in the apparent mass dependencies of environment quenching and mass quenching which produces distinctive signatures in the mass functions of centrals and satellites will arise naturally, since, for satellites at least, the distributions of the environmental variables that we investigate in this work are essentially independent of the stellar mass of the satellite.« less

Decreased centrality of cortical volume covariance networks in autism spectrum disorders.

PubMed

Balardin, Joana Bisol; Comfort, William Edgar; Daly, Eileen; Murphy, Clodagh; Andrews, Derek; Murphy, Declan G M; Ecker, Christine; Sato, João Ricardo

2015-10-01

Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered network-level organization for functional systems and white matter tracts in ASD. However, atypical functional and structural connectivity are likely to be also linked to abnormal development of the correlated structure of cortical gray matter. Such covariations of gray matter are particularly well suited to the investigation of the complex cortical pathology of ASD, which is not confined to isolated brain regions but instead acts at the systems level. In this study, we examined network centrality properties of gray matter networks in adults with ASD (n = 84) and neurotypical controls (n = 84) using graph theoretical analysis. We derived a structural covariance network for each group using interregional correlation matrices of cortical volumes extracted from a surface-based parcellation scheme containing 68 cortical regions. Differences between groups in closeness network centrality measures were evaluated using permutation testing. We identified several brain regions in the medial frontal, parietal and temporo-occipital cortices with reductions in closeness centrality in ASD compared to controls. We also found an association between an increased number of autistic traits and reduced centrality of visual nodes in neurotypicals. Our study shows that ASD are accompanied by atypical organization of structural covariance networks by means of a decreased centrality of regions relevant for social and sensorimotor processing. These findings provide further evidence for the altered network-level connectivity model of ASD. Copyright © 2015 Elsevier Ltd. All rights reserved.

Proportions of maxillary anterior teeth relative to each other and to golden standard in tabriz dental faculty students.

PubMed

Parnia, Fereydoun; Hafezeqoran, Ali; Mahboub, Farhang; Moslehifard, Elnaz; Koodaryan, Rodabeh; Moteyagheni, Rosa; Saleh Saber, Fariba

2010-01-01

Various methods are used to measure the size and form of the teeth, including the golden pro-portion, and the width-to-length ratio of central teeth, referred to as the golden standard. The aim of this study was to eval-uate the occurrence of golden standard values and golden proportion in the anterior teeth. Photographs of 100 dentistry students (50 males and 50 females) were taken under standard conditions. The visible widths and lengths of maxillary right and left incisors were calculated and the ratios were compared with golden standard. Data was analyzed using SPSS 14 software. Review of the results of the means showed statistically significant differences between the width ratio of right lateral teeth to the central teeth width with golden proportion (P<0.001). Likewise, the difference was significant for the left side, too (P<0.001). Test results of mean differences showed that the mean difference between proportion of right laterals to centrals with golden proportion was significant (P<0.001). The difference was significant for the left side, too (P<0.001). As a result, there is no golden proportion among maxillary incisors. The review of results of mean differences for single samples showed that the mean differences between the proportion of width-to-length of left and right central teeth was statistically significant by golden standard (P<0.001). Therefore, considering the width-to-length proportion of maxillary central teeth, no golden standard exists. In the evaluation of the width-to-width and width-to-length proportions of maxillary incisors no golden proportions and standards were detected, respectively.

Family-nurse co-construction of meaning: a central phenomenon of family caring.

PubMed

Meiers, Sonja J; Tomlinson, Patricia S

2003-06-01

The purpose of the study was to understand and interpret caring in the family health experience by exploring the interactional phenomenon of family-nurse co-construction of meaning in the paediatric intensive care unit (PICU). A hermeneutic phenomenological method within a framework of existentialism and symbolic interactionism was used in the investigation. The convenience sample for this study was four family-nurse dyads, that is four families of critically ill children (all with positive outcomes) and the four nurses assigned to their care who were participating in a larger study. Data were derived from semi-structured interviews regarding significant interactions throughout the child's illness and subsequent significant interactions of families with other nurses and nurses with other families. Trustworthiness of the study was addressed through the criteria of credibility, dependability, transferability and confirmability. Co-construction of meaning in the family health experience was found to have two dimensions: interdependent and independent. Both families and nurses described being like family as an essential component of the interdependent experience. Independent dimensions for families were journeying through troubled waters of learning the meaning of the illness event and sensing family comfort through the nurse's care. Independent dimensions described by nurses were journeying through troubled waters of learning to care for families and living with another's fear. The family-nurse interaction, the relational connection and the evolution of meanings that families and nurses construct, was affirmed as the major vehicle in the co-construction experience. Family caring is influenced by the existential meaning constructing, process-oriented, interactional nature of the family health experience. Caring in the family health experience is enhanced through actions the nurse performs on behalf of, and with, the family while understanding the family's unique situation. Caring enacted by nurses in participation with families holds abundant potential for enhancing the family health experience and honor the ethic of caring as central to nursing.

Central venous stenosis in haemodialysis patients without a previous history of catheter placement.

PubMed

Oguzkurt, Levent; Tercan, Fahri; Yildirim, Sedat; Torun, Dilek

2005-08-01

To evaluate dialysis history, imaging findings and outcome of endovascular treatment in six patients with central venous stenosis without a history of previous catheter placement. Between April 2000 and June 2004, six (10%) of 57 haemodialysis patients had stenosis of a central vein without a previous central catheter placement. Venography findings and outcome of endovascular treatment in these six patients were retrospectively evaluated. Patients were three women (50%) and three men aged 32-60 years (mean age: 45 years) and all had massive arm swelling as the main complaint. The vascular accesses were located at the elbow in five patients and at the wrist in one patient. Three patients had stenosis of the left subclavian vein and three patients had stenosis of the left brachiocephalic vein. The mean duration of the vascular accesses from the time of creation was 25.1 months. Flow volumes of the vascular access were very high in four patients who had flow volume measurement. The mean flow volume was 2347 ml/min. One of three patients with brachiocephalic vein stenosis had compression of the vein by the brachiocephalic artery. All the lesions were first treated with balloon angioplasty and two patients required stent placement on long term. Number of interventions ranged from 1 to 4 (mean: 2.1). Symptoms resolved in five patients and improved in one patient who had a stent placed in the left BCV. Central venous stenosis in haemodialysis patients without a history of central venous catheterization tends to occur or be manifested in patients with a proximal permanent vascular access with high flow rates. Balloon angioplasty with or without stent placement offers good secondary patency rates in mid-term.

Relationship between crown-root angulation (collum angle) of maxillary central incisors in Class II, division 2 malocclusion and lower lip line.

PubMed

Srinivasan, Bhadrinath; Kailasam, Vignesh; Chitharanjan, Arun; Ramalingam, Arthi

2013-01-01

The present study aimed to measure the magnitude of the collum angle (crown-root angulation) of maxillary central incisors present in Class II, division 2 malocclusion and to relate the changes in its magnitude with variations in the lower lip line. A set of 120 conventional lateral cephalograms were selected and divided into three groups of 40 each based on the type of malocclusion presented: Class II, division 2 (group 1); Class II, division 1 (group 2); and Class I (group 3). The collum angle of the maxillary central incisor was measured, and the lower lip line was recorded. Analysis of variance (ANOVA) revealed that the mean collum angle was statistically significantly different in the three groups. The mean collum angle was greatest in Class II, division 2 malocclusion (group 1). The mean collum angles were 3.24 ± 4.69 degrees, 0.95 ± 1.06 degrees, and 1.05 ± 1.50 degrees in groups 1, 2, and 3 respectively. In χ ² test comparison of the location of the lower lip line (incisal, middle, or apical third of the central incisor) among the three groups, the lower lip line was found to contact the middle third of the central incisor most frequently in Class II, division 2 malocclusion. ANOVA followed by Tukey honestly significant difference (HSD) test showed that the mean collum angle is significantly increased when the lower lip is in the middle third (P < .05) of the central incisor. Variations in magnitude of the collum angle with the change in the lower lip line suggest a probable etiologic role of the lower lip line in the development of the collum angle.

'A major lobbying effort to change and unify the excise structure in six Central American countries': How British American Tobacco influenced tax and tariff rates in the Central American Common Market.

PubMed

Holden, Chris; Lee, Kelley

2011-05-19

Transnational tobacco companies (TTCs) may respond to processes of regional trade integration both by acting politically to influence policy and by reorganising their own operations. The Central American Common Market (CACM) was reinvigorated in the 1990s, reflecting processes of regional trade liberalisation in Latin America and globally. This study aimed to ascertain how British American Tobacco (BAT), which dominated the markets of the CACM, sought to influence policy towards it by member country governments and how the CACM process impacted upon BAT's operations. The study analysed internal tobacco industry documents released as a result of litigation in the US and available from the online Legacy Tobacco Documents Library at http://legacy.library.ucsf.edu/. Documents were retrieved by searching the BAT collection using key terms in an iterative process. Analysis was based on an interpretive approach involving a process of attempting to understand the meanings of individual documents and relating these to other documents in the set, identifying the central themes of documents and clusters of documents, contextualising the documentary data, and choosing representative material in order to present findings. Utilising its multinational character, BAT was able to act in a coordinated way across the member countries of the CACM to influence tariffs and taxes to its advantage. Documents demonstrate a high degree of access to governments and officials. The company conducted a coordinated, and largely successful, attempt to keep external tariff rates for cigarettes high and to reduce external tariffs for key inputs, whilst also influencing the harmonisation of excise taxes between countries. Protected by these high external tariffs, it reorganised its own operations to take advantage of regional economies of scale. In direct contradiction to arguments presented to CACM governments that affording the tobacco industry protection via high cigarette tariffs would safeguard employment, the company's regional reorganisation involved the loss of hundreds of jobs. Regional integration organisations and their member states should be aware of the capacity of TTCs to act in a coordinated transnational manner to influence policy in their own interests, and coordinate their own public health and tax policies in a similarly effective way.

'A major lobbying effort to change and unify the excise structure in six Central American countries': How British American Tobacco influenced tax and tariff rates in the Central American Common Market

PubMed Central

2011-01-01

Background Transnational tobacco companies (TTCs) may respond to processes of regional trade integration both by acting politically to influence policy and by reorganising their own operations. The Central American Common Market (CACM) was reinvigorated in the 1990s, reflecting processes of regional trade liberalisation in Latin America and globally. This study aimed to ascertain how British American Tobacco (BAT), which dominated the markets of the CACM, sought to influence policy towards it by member country governments and how the CACM process impacted upon BAT's operations. Methods The study analysed internal tobacco industry documents released as a result of litigation in the US and available from the online Legacy Tobacco Documents Library at http://legacy.library.ucsf.edu/. Documents were retrieved by searching the BAT collection using key terms in an iterative process. Analysis was based on an interpretive approach involving a process of attempting to understand the meanings of individual documents and relating these to other documents in the set, identifying the central themes of documents and clusters of documents, contextualising the documentary data, and choosing representative material in order to present findings. Results Utilising its multinational character, BAT was able to act in a coordinated way across the member countries of the CACM to influence tariffs and taxes to its advantage. Documents demonstrate a high degree of access to governments and officials. The company conducted a coordinated, and largely successful, attempt to keep external tariff rates for cigarettes high and to reduce external tariffs for key inputs, whilst also influencing the harmonisation of excise taxes between countries. Protected by these high external tariffs, it reorganised its own operations to take advantage of regional economies of scale. In direct contradiction to arguments presented to CACM governments that affording the tobacco industry protection via high cigarette tariffs would safeguard employment, the company's regional reorganisation involved the loss of hundreds of jobs. Conclusions Regional integration organisations and their member states should be aware of the capacity of TTCs to act in a coordinated transnational manner to influence policy in their own interests, and coordinate their own public health and tax policies in a similarly effective way. PMID:21595921

Whether a Building or a State of Mind, the Central Office Must Evolve

ERIC Educational Resources Information Center

Mizell, Hayes

2010-01-01

The central office is both a physical place and a state of mind. In some school systems, the central office is a separate building located away from schools. In other communities, the office is housed in one of the school buildings. When someone mentions "central office," they may not be referring only to the building. They may also mean the tip…

Lean oncology: a new model for oncologists.

PubMed

Montesarchio, Vincenzo; Grimaldi, Antonio Maria; Fox, Bernard A; Rea, Antonio; Marincola, Francesco M; Ascierto, Paolo A

2012-04-25

The history of the term Lean is relatively recent and originates from the Toyota Production System (TPS). The term "Lean" means "thin", which refers to a mental process, operational, productive, no-frills, quick but not hasty, consequential to the previous event. The Lean process flows seamlessly into the result, eliminates unnecessary complications to the effect, prevents unnecessary equipment processes. The idea is to 'do more with less', like using the (few) available resources in the most productive way possible, through the elimination of all types of waste that inevitably accompanies every stage of a production process. Lean management is primarily a management philosophy, a system of values and behaviors that goes beyond the mere application of the instrument and that, once internalized, will form the nucleus of the corporate culture. "Lean Oncology" is a term coined to identify a methodology of care and treatment to cancer patients, consisting on process simplification, streamlining of the organizational and routes of drug treatment, detection and elimination of waste. Its main objective is the centrality of the patient.

Central Auditory Processing of Temporal and Spectral-Variance Cues in Cochlear Implant Listeners

PubMed Central

Pham, Carol Q.; Bremen, Peter; Shen, Weidong; Yang, Shi-Ming; Middlebrooks, John C.; Zeng, Fan-Gang; Mc Laughlin, Myles

2015-01-01

Cochlear implant (CI) listeners have difficulty understanding speech in complex listening environments. This deficit is thought to be largely due to peripheral encoding problems arising from current spread, which results in wide peripheral filters. In normal hearing (NH) listeners, central processing contributes to segregation of speech from competing sounds. We tested the hypothesis that basic central processing abilities are retained in post-lingually deaf CI listeners, but processing is hampered by degraded input from the periphery. In eight CI listeners, we measured auditory nerve compound action potentials to characterize peripheral filters. Then, we measured psychophysical detection thresholds in the presence of multi-electrode maskers placed either inside (peripheral masking) or outside (central masking) the peripheral filter. This was intended to distinguish peripheral from central contributions to signal detection. Introduction of temporal asynchrony between the signal and masker improved signal detection in both peripheral and central masking conditions for all CI listeners. Randomly varying components of the masker created spectral-variance cues, which seemed to benefit only two out of eight CI listeners. Contrastingly, the spectral-variance cues improved signal detection in all five NH listeners who listened to our CI simulation. Together these results indicate that widened peripheral filters significantly hamper central processing of spectral-variance cues but not of temporal cues in post-lingually deaf CI listeners. As indicated by two CI listeners in our study, however, post-lingually deaf CI listeners may retain some central processing abilities similar to NH listeners. PMID:26176553

The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study

PubMed Central

Patel, Sumaiya; Lawlor, Debbie A.; Ferreira, Diana L.S.; Hughes, Alun D.; Chaturvedi, Nish; Callaway, Mark; Day, Chris; Sattar, Naveed; Fraser, Abigail

2015-01-01

Objectives: We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity. Methods: Using cross-sectional data from a subsample (N = 1904) of a UK birth cohort, we assessed markers of NAFLD including ultrasound scan (USS) determined fatty liver, shear velocity (marker of liver fibrosis), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) at a mean age of 17.8 years. These were related to BP [central and peripheral SBP and DBP and mean arterial pressure (MAP)]. Results: Fatty liver was positively associated with central and peripheral SBP, DBP and MAP in models adjusting for age, sex, social class, puberty and alcohol intake. These positive associations were attenuated to the null when fat mass was included. For example, in confounder-adjusted models, not including fat mass, mean central SBP was 3.74 mmHg [95% confidence interval (CI) 1.12 to 6.36] higher in adolescents with USS fatty liver than in those without; with additional adjustment for fat mass, the association attenuated to the null value (−0.37 mmHg; 95% CI –3.09 to 2.36). Similar patterns were found for associations of ALT and GGT with central and peripheral BP. There was no consistent evidence of associations of shear velocity or AST with BP measurements. Fatty liver was not consistently associated with central pulse pressure (PP), peripheral PP and Aix@75. Conclusion: NAFLD is not associated with higher central or peripheral BP in adolescents once confounding by adiposity is taken into account. PMID:25426570

Increased arterial stiffness in children with congenital heart disease.

PubMed

Häcker, Anna-Luisa; Reiner, Barbara; Oberhoffer, Renate; Hager, Alfred; Ewert, Peter; Müller, Jan

2018-01-01

Objective Central systolic blood pressure (SBP) is a measure of arterial stiffness and strongly associated with atherosclerosis and end-organ damage. It is a stronger predictor of cardiovascular events and all-cause mortality than peripheral SBP. In particular, for children with congenital heart disease, a higher central SBP might impose a greater threat of cardiac damage. The aim of the study was to analyse and compare central SBP in children with congenital heart disease and in healthy counterparts. Patients and methods Central SBP was measured using an oscillometric method in 417 children (38.9% girls, 13.0 ± 3.2 years) with various congenital heart diseases between July 2014 and February 2017. The test results were compared with a recent healthy reference cohort of 1466 children (49.5% girls, 12.9 ± 2.5 years). Results After correction for several covariates in a general linear model, central SBP of children with congenital heart disease was significantly increased (congenital heart disease: 102.1 ± 10.2 vs. healthy reference cohort: 100.4 ± 8.6, p < .001). The analysis of congenital heart disease subgroups revealed higher central SBP in children with left heart obstructions (mean difference: 3.6 mmHg, p < .001), transpositions of the great arteries after arterial switch (mean difference: 2.2 mmHg, p = .017) and univentricular hearts after total cavopulmonary connection (mean difference: 2.1 mmHg, p = .015) compared with the reference. Conclusion Children with congenital heart disease have significantly higher central SBP compared with healthy peers, predisposing them to premature heart failure. Screening and long-term observations of central SBP in children with congenital heart disease seems warranted in order to evaluate the need for treatment.

Validity and reliability of central blood pressure estimated by upper arm oscillometric cuff pressure.

PubMed

Climie, Rachel E D; Schultz, Martin G; Nikolic, Sonja B; Ahuja, Kiran D K; Fell, James W; Sharman, James E

2012-04-01

Noninvasive central blood pressure (BP) independently predicts mortality, but current methods are operator-dependent, requiring skill to obtain quality recordings. The aims of this study were first, to determine the validity of an automatic, upper arm oscillometric cuff method for estimating central BP (O(CBP)) by comparison with the noninvasive reference standard of radial tonometry (T(CBP)). Second, we determined the intratest and intertest reliability of O(CBP). To assess validity, central BP was estimated by O(CBP) (Pulsecor R6.5B monitor) and compared with T(CBP) (SphygmoCor) in 47 participants free from cardiovascular disease (aged 57 ± 9 years) in supine, seated, and standing positions. Brachial mean arterial pressure (MAP) and diastolic BP (DBP) from the O(CBP) device were used to calibrate in both devices. Duplicate measures were recorded in each position on the same day to assess intratest reliability, and participants returned within 10 ± 7 days for repeat measurements to assess intertest reliability. There was a strong intraclass correlation (ICC = 0.987, P < 0.001) and small mean difference (1.2 ± 2.2 mm Hg) for central systolic BP (SBP) determined by O(CBP) compared with T(CBP). Ninety-six percent of all comparisons (n = 495 acceptable recordings) were within 5 mm Hg. With respect to reliability, there were strong correlations but higher limits of agreement for the intratest (ICC = 0.975, P < 0.001, mean difference 0.6 ± 4.5 mm Hg) and intertest (ICC = 0.895, P < 0.001, mean difference 4.3 ± 8.0 mm Hg) comparisons. Estimation of central SBP using cuff oscillometry is comparable to radial tonometry and has good reproducibility. As a noninvasive, relatively operator-independent method, O(CBP) may be as useful as T(CBP) for estimating central BP in clinical practice.

Reduced beta connectivity during emotional face processing in adolescents with autism.

PubMed

Leung, Rachel C; Ye, Annette X; Wong, Simeon M; Taylor, Margot J; Doesburg, Sam M

2014-01-01

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social cognition. The biological basis of deficits in social cognition in ASD, and their difficulty in processing emotional face information in particular, remains unclear. Atypical communication within and between brain regions has been reported in ASD. Interregional phase-locking is a neurophysiological mechanism mediating communication among brain areas and is understood to support cognitive functions. In the present study we investigated interregional magnetoencephalographic phase synchronization during the perception of emotional faces in adolescents with ASD. A total of 22 adolescents with ASD (18 males, mean age =14.2 ± 1.15 years, 22 right-handed) with mild to no cognitive delay and 17 healthy controls (14 males, mean age =14.4 ± 0.33 years, 16 right-handed) performed an implicit emotional processing task requiring perception of happy, angry and neutral faces while we recorded neuromagnetic signals. The faces were presented rapidly (80 ms duration) to the left or right of a central fixation cross and participants responded to a scrambled pattern that was presented concurrently on the opposite side of the fixation point. Task-dependent interregional phase-locking was calculated among source-resolved brain regions. Task-dependent increases in interregional beta synchronization were observed. Beta-band interregional phase-locking in adolescents with ASD was reduced, relative to controls, during the perception of angry faces in a distributed network involving the right fusiform gyrus and insula. No significant group differences were found for happy or neutral faces, or other analyzed frequency ranges. Significant reductions in task-dependent beta connectivity strength, clustering and eigenvector centrality (all P <0.001) in the right insula were found in adolescents with ASD, relative to controls. Reduced beta synchronization may reflect inadequate recruitment of task-relevant networks during emotional face processing in ASD. The right insula, specifically, was a hub of reduced functional connectivity and may play a prominent role in the inability to effectively extract emotional information from faces. These findings suggest that functional disconnection in brain networks mediating emotional processes may contribute to deficits in social cognition in this population.

An Coral Ensemble Approach to Reconstructing Central Pacific Climate Change During the Holocene

NASA Astrophysics Data System (ADS)

Atwood, A. R.; Cobb, K. M.; Grothe, P. R.; Sayani, H. R.; Southon, J. R.; Edwards, R. L.; Deocampo, D.; Chen, T.; Townsend, K. J.; Hagos, M. M.; Chiang, J. C. H.

2016-12-01

The processes that control El Niño-Southern Oscillation (ENSO) variability on long timescales are still poorly understood. As a consequence, limited progress has been made in understanding how ENSO will change under greenhouse gas forcing. The mid-Holocene provides a well-defined target to study the fundamental controls of ENSO variability. A large number of paleo-ENSO records spanning the tropical Pacific indicate that ENSO variability was reduced by as much as 50% between 3000-6000 yr BP, relative to modern times. Dynamical models of ENSO suggest that ENSO properties can shift in response to changes in the tropical Pacific mean state and/or seasonal cycle, but few proxy records can resolve such changes during the interval in question with enough accuracy. While decades of research have demonstrated the fidelity of tropical Pacific coral d18O records to quantify interannual temperature and precipitation anomalies associated with ENSO, substantial mean offsets exist across overlapping coral sequences that have made it difficult to quantify past changes in mean climate. Here, we test a new approach to reconstruct changes in mean climate from coral records using a large ensemble of bulk d18O measurements on radiometrically-dated fossil corals from Christmas Island that span the Holocene. In contrast to the traditional method of high-resolution sampling to reconstruct monthly climate conditions, we implement a bulk approach, which dramatically reduces the analysis time needed to estimate mean coral d18O and enables a large number of corals to be analyzed in the production of an ensemble of mean climate estimates. A pseudo-coral experiment based on simulations with a Linear Inverse Model and a coupled GCM is used to determine the number of bulk coral estimates that are required to resolve a given mean climate perturbation. In addition to these bulk measurements, short transects are sampled at high resolution to constrain changes in the amplitude of the seasonal cycle. We present preliminary results from our joint bulk/high-resolution sampling approach that provide new constraints on changes in mean climate and seasonality in the central equatorial Pacific over the last 6,000 yr BP.

Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis.

PubMed

Gorka, Adam X; Torrisi, Salvatore; Shackman, Alexander J; Grillon, Christian; Ernst, Monique

2018-03-01

The central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), two nuclei within the central extended amygdala, function as critical relays within the distributed neural networks that coordinate sensory, emotional, and cognitive responses to threat. These structures have overlapping anatomical projections to downstream targets that initiate defensive responses. Despite these commonalities, researchers have also proposed a functional dissociation between the CeA and BNST, with the CeA promoting responses to discrete stimuli and the BNST promoting responses to diffuse threat. Intrinsic functional connectivity (iFC) provides a means to investigate the functional architecture of the brain, unbiased by task demands. Using ultra-high field neuroimaging (7-Tesla fMRI), which provides increased spatial resolution, this study compared the iFC networks of the CeA and BNST in 27 healthy individuals. Both structures were coupled with areas of the medial prefrontal cortex, hippocampus, thalamus, and periaqueductal gray matter. Compared to the BNST, the bilateral CeA was more strongly coupled with the insula and regions that support sensory processing, including thalamus and fusiform gyrus. In contrast, the bilateral BNST was more strongly coupled with regions involved in cognitive and motivational processes, including the dorsal paracingulate gyrus, posterior cingulate cortex, and striatum. Collectively, these findings suggest that responses to sensory stimulation are preferentially coordinated by the CeA and cognitive and motivational responses are preferentially coordinated by the BNST. Published by Elsevier Inc.

Numerical simulation of turbulent flows over crater-like obstacles: application to Gale crater, landing site of the Curiosity rover

NASA Astrophysics Data System (ADS)

Anderson, W.; Day, M. D.

2017-12-01

Mars is a dry planet with a thin atmosphere. Aeolian processes - wind-driven mobilization of sediment and dust - are the dominant mode of landscape variability on the dessicated landscapes of Mars. Craters are common topographic features on the surface of Mars, and many craters on Mars contain a prominent central mound (NASA's Curiosity rover was landed in Gale crater, with the rover journeying across an inner plan and towards Gale's central mound, Aeolus Mons). These mounds are composed of sedimentary fill, and, therefore, they contain rich information on the evolution of climatic conditions on Mars embodied in the stratigraphic "layering" of sediments. Many other craters no longer house a mound, but contain sediment and dust from which dune fields and other features form. Using density-normalized large-eddy simulations, we have modeled turbulent flows over crater-like topographies that feature a central mound. Resultant datasets suggest a deflationary mechanism wherein vortices shed from the upwind crater rim are realigned to conform to the crater profile via stretching and tilting. This insight was gained using three-dimensional datasets (momentum, vorticity, and turbulent stresses) retrieved from LES, and assessment of the relative influence of constituent terms responsible for the sustenance of mean vorticity. The helical, counter-rotating vortices occupy the inner region of the crater, and, therefore, are argued to be of great importance for aeolian morphodynamics in the crater (radial katabatic flows are also important to aeolian processes within the crater).

Impact of land use/land cover change on changes in surface solar radiation in eastern China since the reform and opening up

NASA Astrophysics Data System (ADS)

Qian, Cheng

2016-01-01

Observational evidence of the impacts of land use/land cover change (LULCC) on changes in surface solar radiation (SSR) in eastern China (EC) during 1979-2008 are identified by using diurnal temperature range as a proxy of SSR and by using observation minus reanalysis approach to disentangle these effects. For the period 1979-2008, the impact of LULCC is shown as a reduction in SSR in most stations in EC, whereas SSR in the reanalysis data has increased at nearly every location. The competition of the dimming effect of LULCC with the brightening effect in the reanalysis results in an observed dipole pattern of SSR with slightly decreasing (increasing) trends in most stations north (south) of the Yangtze River and statistically significant decreasing trends in central EC. In terms of EC area mean, this competition has resulted in a slightly dimming trend in the observed SSR during 1979-2008, although a transition from an apparent dimming to a general leveling off near 1990 is identified. For the period 1990-2008, LULCC has significantly reduced SSR in central EC and southern China. This dimming effect of LULCC competes with the apparent brightening effect in the reanalysis to result in the general leveling off in the observed SSR in terms of EC area mean and a sandwich spatial pattern in the observed SSR in EC where parts of central EC show significant dimming. The impact of LULCC on the changes in SSR may be through both biogeophysical and biogeochemical processes.

The epistemic and aleatory uncertainties of the ETAS-type models: an application to the Central Italy seismicity.

PubMed

Lombardi, A M

2017-09-18

Stochastic models provide quantitative evaluations about the occurrence of earthquakes. A basic component of this type of models are the uncertainties in defining main features of an intrinsically random process. Even if, at a very basic level, any attempting to distinguish between types of uncertainty is questionable, an usual way to deal with this topic is to separate epistemic uncertainty, due to lack of knowledge, from aleatory variability, due to randomness. In the present study this problem is addressed in the narrow context of short-term modeling of earthquakes and, specifically, of ETAS modeling. By mean of an application of a specific version of the ETAS model to seismicity of Central Italy, recently struck by a sequence with a main event of Mw6.5, the aleatory and epistemic (parametric) uncertainty are separated and quantified. The main result of the paper is that the parametric uncertainty of the ETAS-type model, adopted here, is much lower than the aleatory variability in the process. This result points out two main aspects: an analyst has good chances to set the ETAS-type models, but he may retrospectively describe and forecast the earthquake occurrences with still limited precision and accuracy.

Iconic Meaning in Music: An Event-Related Potential Study.

PubMed

Cai, Liman; Huang, Ping; Luo, Qiuling; Huang, Hong; Mo, Lei

2015-01-01

Although there has been extensive research on the processing of the emotional meaning of music, little is known about other aspects of listeners' experience of music. The present study investigated the neural correlates of the iconic meaning of music. Event-related potentials (ERP) were recorded while a group of 20 music majors and a group of 20 non-music majors performed a lexical decision task in the context of implicit musical iconic meaning priming. ERP analysis revealed a significant N400 effect of congruency in time window 260-510 ms following the onset of the target word only in the group of music majors. Time-course analysis using 50 ms windows indicated significant N400 effects both within the time window 410-460 ms and 460-510 ms for music majors, whereas only a partial N400 effect during time window 410-460 ms was observed for non-music majors. There was also a trend for the N400 effects in the music major group to be stronger than those in the non-major group in the sub-windows of 310-360 ms and 410-460 ms. Especially in the sub-window of 410-460 ms, the topographical map of the difference waveforms between congruent and incongruent conditions revealed different N400 distribution between groups; the effect was concentrated in bilateral frontal areas for music majors, but in central-parietal areas for non-music majors. These results imply probable neural mechanism differences underlying automatic iconic meaning priming of music. Our findings suggest that processing of the iconic meaning of music can be accomplished automatically and that musical training may facilitate the understanding of the iconic meaning of music.

Iconic Meaning in Music: An Event-Related Potential Study

PubMed Central

Luo, Qiuling; Huang, Hong; Mo, Lei

2015-01-01

Although there has been extensive research on the processing of the emotional meaning of music, little is known about other aspects of listeners’ experience of music. The present study investigated the neural correlates of the iconic meaning of music. Event-related potentials (ERP) were recorded while a group of 20 music majors and a group of 20 non-music majors performed a lexical decision task in the context of implicit musical iconic meaning priming. ERP analysis revealed a significant N400 effect of congruency in time window 260-510 ms following the onset of the target word only in the group of music majors. Time-course analysis using 50 ms windows indicated significant N400 effects both within the time window 410-460 ms and 460-510 ms for music majors, whereas only a partial N400 effect during time window 410-460 ms was observed for non-music majors. There was also a trend for the N400 effects in the music major group to be stronger than those in the non-major group in the sub-windows of 310-360ms and 410-460ms. Especially in the sub-window of 410-460 ms, the topographical map of the difference waveforms between congruent and incongruent conditions revealed different N400 distribution between groups; the effect was concentrated in bilateral frontal areas for music majors, but in central-parietal areas for non-music majors. These results imply probable neural mechanism differences underlying automatic iconic meaning priming of music. Our findings suggest that processing of the iconic meaning of music can be accomplished automatically and that musical training may facilitate the understanding of the iconic meaning of music. PMID:26161561

FUNDUS AUTOFLUORESCENCE LIFETIMES AND CENTRAL SEROUS CHORIORETINOPATHY

PubMed Central

Dysli, Chantal; Berger, Lieselotte; Wolf, Sebastian

2017-01-01

Purpose: To quantify retinal fluorescence lifetimes in patients with central serous chorioretinopathy (CSC) and to identify disease specific lifetime characteristics over the course of disease. Methods: Forty-seven participants were included in this study. Patients with central serous chorioretinopathy were imaged with fundus photography, fundus autofluorescence, optical coherence tomography, and fluorescence lifetime imaging ophthalmoscopy (FLIO) and compared with age-matched controls. Retinal autofluorescence was excited using a 473-nm blue laser light and emitted fluorescence light was detected in 2 distinct wavelengths channels (498–560 nm and 560–720 nm). Clinical features, mean retinal autofluorescence lifetimes, autofluorescence intensity, and corresponding optical coherence tomography (OCT) images were further analyzed. Results: Thirty-five central serous chorioretinopathy patients with a mean visual acuity of 78 ETDRS letters (range, 50–90; mean Snellen equivalent: 20/32) and 12 age-matched controls were included. In the acute stage of central serous chorioretinopathy, retinal fluorescence lifetimes were shortened by 15% and 17% in the respective wavelength channels. Multiple linear regression analysis showed that fluorescence lifetimes were significantly influenced by the disease duration (P < 0.001) and accumulation of photoreceptor outer segments (P = 0.03) but independent of the presence or absence of subretinal fluid. Prolonged central macular autofluorescence lifetimes, particularly in eyes with retinal pigment epithelial atrophy, were associated with poor visual acuity. Conclusion: This study establishes that autofluorescence lifetime changes occurring in central serous chorioretinopathy exhibit explicit patterns which can be used to estimate perturbations of the outer retinal layers with a high degree of statistical significance. PMID:28099314

Amodal processing in human prefrontal cortex.

PubMed

Tamber-Rosenau, Benjamin J; Dux, Paul E; Tombu, Michael N; Asplund, Christopher L; Marois, René

2013-07-10

Information enters the cortex via modality-specific sensory regions, whereas actions are produced by modality-specific motor regions. Intervening central stages of information processing map sensation to behavior. Humans perform this central processing in a flexible, abstract manner such that sensory information in any modality can lead to response via any motor system. Cognitive theories account for such flexible behavior by positing amodal central information processing (e.g., "central executive," Baddeley and Hitch, 1974; "supervisory attentional system," Norman and Shallice, 1986; "response selection bottleneck," Pashler, 1994). However, the extent to which brain regions embodying central mechanisms of information processing are amodal remains unclear. Here we apply multivariate pattern analysis to functional magnetic resonance imaging (fMRI) data to compare response selection, a cognitive process widely believed to recruit an amodal central resource across sensory and motor modalities. We show that most frontal and parietal cortical areas known to activate across a wide variety of tasks code modality, casting doubt on the notion that these regions embody a central processor devoid of modality representation. Importantly, regions of anterior insula and dorsolateral prefrontal cortex consistently failed to code modality across four experiments. However, these areas code at least one other task dimension, process (instantiated as response selection vs response execution), ensuring that failure to find coding of modality is not driven by insensitivity of multivariate pattern analysis in these regions. We conclude that abstract encoding of information modality is primarily a property of subregions of the prefrontal cortex.

Central depression in nuclear density and its consequences for the shell structure of superheavy nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Afanasjev, A.V.; Laboratory of Radiation Physics, Institute of Solid State Physics, University of Latvia, LV 2169 Salaspils, Miera str. 31; Frauendorf, S.

The influence of the central depression in the density distribution of spherical superheavy nuclei on the shell structure is studied within the relativistic mean-field theory. A large depression leads to the shell gaps at the proton Z=120 and neutron N=172 numbers, whereas a flatter density distribution favors N=184 and leads to the appearance of a Z=126 shell gap and to the decrease of the size of the Z=120 shell gap. The correlations between the magic shell gaps and the magnitude of the central depression are discussed for relativistic and nonrelativistic mean field theories.

4H Syndrome

MedlinePlus

... syndrome? 4H syndrome is short for hypomyelination, hypogonadotropic hypogonadism and hypodontia. Hypomyelination means that there is lack ... myelin in the central nervous system. In hypogonadotropic hypogonadism, normal puberty development is absent because the central ...

Assessing Saudi medical students learning approach using the revised two-factor study process questionnaire.

PubMed

Shaik, Shaffi Ahamed; Almarzuqi, Ahmed; Almogheer, Rakan; Alharbi, Omar; Jalal, Abdulaziz; Alorainy, Majed

2017-08-17

To assess learning approaches of 1st, 2nd, and 3rd-year medical students by using revised two-factor study process questionnaire, and to assess reliability and validity of the questionnaire. This cross-sectional study was conducted at the College of Medicine, Riyadh, Saudi Arabia in 2014. The revised two-factor study process questionnaire (R-SPQ-2F) was completed by 610 medical students of both genders, from foundation (first year), central nervous system (second year), medicine and surgery (third year) courses. The study process was evaluated by computing mean scores of two research study approaches (deep & surface) using student's t-test and one-way analysis of variance. The internal consistency and construct validity of the questionnaire were assessed using Cronbach's α and factor analysis. The mean score of deep approach was significantly higher than the surface approach among participants(t (770) =7.83, p= 0.000) for the four courses. The mean scores of deep approach were significantly higher among participants with higher grade point average (F (2,768) =13.31, p=0.001) along with more number of study hours by participants (F (2,768) =20.08, p=0.001). The Cronbach's α-values of items at 0.70 indicate the good internal consistency of questionnaire used. Factor analysis confirms two factors (deep and surface approaches) of R-SPQ-2F. The deep approach to learning was the primary approach among 1st, 2nd and 3rd-year King Saud University medical students. This study confirms reliability and validity of the revised two-factor study process questionnaire. Medical educators could use the results of such studies to make required changes in the curriculum.

Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: An immunohistochemical analysis

PubMed Central

VK, Varsha; Hallikeri, Kaveri; Girish, HC; Murgod, Sanjay

2014-01-01

Background: Central and Peripheral giant cell granulomas of jaws are uncommon, benign, reactive disorders that are characterized by the presence of numerous multinucleated giant cells and mononuclear cells within a stroma. The origin of the multinucleated giant cells is controversial; probably originating from fusion of histiocytes, endothelial cells and fibroblasts. Objective: To assess the expression of CD34 and CD68 in central and peripheral giant cell granulomas to understand the origin of these multinucleated giant cells. Materials and Methods: Twenty cases of Central and Peripheral giant cell granulomas were evaluated immunohistochemically for CD34 and CD68 proteins expression. Results: Immunopositivity for CD34 was seen only in cytoplasm of endothelial cells of blood vessels; whereas, consistent cytoplasmic immunopositivity for CD68 was seen in few stromal cells. Statistical significance was seen in mean number of multinucleated giant cells, mean number of nuclei in multinucleated giant cells, CD68 expression and ratio of macrophages to multinucleated giant cells among two lesions. Conclusion: Although the central giant cell granulomas share some clinical and histopathological similarities with peripheral giant cell granulomas, differences in mean number of nuclei in multinucleated giant cells and CD68 immunoreactivity may underlie the distinct clinical behavior. PMID:25948986

Behavioral Signs of (Central) Auditory Processing Disorder in Children With Nonsyndromic Cleft Lip and/or Palate: A Parental Questionnaire Approach.

PubMed

Ma, Xiaoran; McPherson, Bradley; Ma, Lian

2016-03-01

Objective Children with nonsyndromic cleft lip and/or palate often have a high prevalence of middle ear dysfunction. However, there are also indications that they may have a higher prevalence of (central) auditory processing disorder. This study used Fisher's Auditory Problems Checklist for caregivers to determine whether children with nonsyndromic cleft lip and/or palate have potentially more auditory processing difficulties compared with craniofacially normal children. Methods Caregivers of 147 school-aged children with nonsyndromic cleft lip and/or palate were recruited for the study. This group was divided into three subgroups: cleft lip, cleft palate, and cleft lip and palate. Caregivers of 60 craniofacially normal children were recruited as a control group. Hearing health tests were conducted to evaluate peripheral hearing. Caregivers of children who passed this assessment battery completed Fisher's Auditory Problems Checklist, which contains 25 questions related to behaviors linked to (central) auditory processing disorder. Results Children with cleft palate showed the lowest scores on the Fisher's Auditory Problems Checklist questionnaire, consistent with a higher index of suspicion for (central) auditory processing disorder. There was a significant difference in the manifestation of (central) auditory processing disorder-linked behaviors between the cleft palate and the control groups. The most common behaviors reported in the nonsyndromic cleft lip and/or palate group were short attention span and reduced learning motivation, along with hearing difficulties in noise. Conclusion A higher occurrence of (central) auditory processing disorder-linked behaviors were found in children with nonsyndromic cleft lip and/or palate, particularly cleft palate. Auditory processing abilities should not be ignored in children with nonsyndromic cleft lip and/or palate, and it is necessary to consider assessment tests for (central) auditory processing disorder when an auditory diagnosis is made for this population.

Manually controlled human balancing using visual, vestibular and proprioceptive senses involves a common, low frequency neural process

PubMed Central

Lakie, Martin; Loram, Ian D

2006-01-01

Ten subjects balanced their own body or a mechanically equivalent unstable inverted pendulum by hand, through a compliant spring linkage. Their balancing process was always characterized by repeated small reciprocating hand movements. These bias adjustments were an observable sign of intermittent alterations in neural output. On average, the adjustments occurred at intervals of ∼400 ms. To generate appropriate stabilizing bias adjustments, sensory information about body or load movement is needed. Subjects used visual, vestibular or proprioceptive sensation alone and in combination to perform the tasks. We first ask, is the time between adjustments (bias duration) sensory specific? Vision is associated with slow responses. Other senses involved with balance are known to be faster. Our second question is; does bias duration depend on sensory abundance? An appropriate bias adjustment cannot occur until unplanned motion is unambiguously perceived (a sensory threshold). The addition of more sensory data should therefore expedite action, decreasing the mean bias adjustment duration. Statistical analysis showed that (1) the mean bias adjustment duration was remarkably independent of the sensory modality and (2) the addition of one or two sensory modalities made a small, but significant, decrease in the mean bias adjustment duration. Thus, a threshold effect can alter only a very minor part of the bias duration. The bias adjustment duration in manual balancing must reflect something more than visual sensation and perceptual thresholds; our suggestion is that it is a common central motor planning process. We predict that similar processes may be identified in the control of standing. PMID:16959857

Contrasting effects of feature-based statistics on the categorisation and identification of visual objects

PubMed Central

Taylor, Kirsten I.; Devereux, Barry J.; Acres, Kadia; Randall, Billi; Tyler, Lorraine K.

2013-01-01

Conceptual representations are at the heart of our mental lives, involved in every aspect of cognitive functioning. Despite their centrality, a long-standing debate persists as to how the meanings of concepts are represented and processed. Many accounts agree that the meanings of concrete concepts are represented by their individual features, but disagree about the importance of different feature-based variables: some views stress the importance of the information carried by distinctive features in conceptual processing, others the features which are shared over many concepts, and still others the extent to which features co-occur. We suggest that previously disparate theoretical positions and experimental findings can be unified by an account which claims that task demands determine how concepts are processed in addition to the effects of feature distinctiveness and co-occurrence. We tested these predictions in a basic-level naming task which relies on distinctive feature information (Experiment 1) and a domain decision task which relies on shared feature information (Experiment 2). Both used large-scale regression designs with the same visual objects, and mixed-effects models incorporating participant, session, stimulus-related and feature statistic variables to model the performance. We found that concepts with relatively more distinctive and more highly correlated distinctive relative to shared features facilitated basic-level naming latencies, while concepts with relatively more shared and more highly correlated shared relative to distinctive features speeded domain decisions. These findings demonstrate that the feature statistics of distinctiveness (shared vs. distinctive) and correlational strength, as well as the task demands, determine how concept meaning is processed in the conceptual system. PMID:22137770

Study on intelligent processing system of man-machine interactive garment frame model

NASA Astrophysics Data System (ADS)

Chen, Shuwang; Yin, Xiaowei; Chang, Ruijiang; Pan, Peiyun; Wang, Xuedi; Shi, Shuze; Wei, Zhongqian

2018-05-01

A man-machine interactive garment frame model intelligent processing system is studied in this paper. The system consists of several sensor device, voice processing module, mechanical parts and data centralized acquisition devices. The sensor device is used to collect information on the environment changes brought by the body near the clothes frame model, the data collection device is used to collect the information of the environment change induced by the sensor device, voice processing module is used for speech recognition of nonspecific person to achieve human-machine interaction, mechanical moving parts are used to make corresponding mechanical responses to the information processed by data collection device.it is connected with data acquisition device by a means of one-way connection. There is a one-way connection between sensor device and data collection device, two-way connection between data acquisition device and voice processing module. The data collection device is one-way connection with mechanical movement parts. The intelligent processing system can judge whether it needs to interact with the customer, realize the man-machine interaction instead of the current rigid frame model.

Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?

PubMed

Naismith, Sharon L; Mowszowski, Loren; Ward, Philip B; Diamond, Keri; Paradise, Matthew; Kaur, Manreena; Lewis, Simon J G; Hickie, Ian B; Hermens, Daniel F

2012-04-01

Depression in older people has been consistently linked with a variety of neurobiological brain changes. One measure of preattentive auditory processing, the mismatch negativity (MMN), has not been previously examined in late-life depression. This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability. Twenty-two older health-seeking patients (mean age=65.2 years) with lifetime major depressive disorder and twelve age and sex-matched control participants (mean age=64.6 years) completed detailed clinical and neuropsychological assessments and the WHO-DAS as a measure of disability. MMN amplitudes were elicited using a two-tone passive auditory oddball paradigm and measured at frontal (Fz), central (Cz) and temporal (left and right mastoid: M1 and M2, respectively) sites. Patients with depression demonstrated reduced mean MMN amplitude at temporal (M1, t=3.1, p<0.01; M2, t=3.8, p<0.01), but not fronto-central sites. Reduced temporal MMN amplitudes did not relate to depressive symptom severity, but were associated with reduced semantic fluency and greater self-rated functional disability. The contribution of depressive symptom 'state' and medications on MMN need to be considered. Reduced mean amplitudes of mastoid MMN in older patients with lifetime depression may reflect underlying brain changes. This preattentive marker relates to neuropsychological probes of frontotemporal circuits, and importantly, is associated with disability. Longitudinal analysis of MMN in this group will determine its predictive utility as a biomarker for ongoing cognitive decline and illness chronicity. Copyright © 2012 Elsevier B.V. All rights reserved.

Cognitive performance in children with acute early-onset anorexia nervosa.

PubMed

van Noort, Betteke Maria; Pfeiffer, Ernst; Ehrlich, Stefan; Lehmkuhl, Ulrike; Kappel, Viola

2016-11-01

When anorexia nervosa (AN) occurs in children below the age of 14 years, it is referred to as early-onset AN (EO-AN). Over the last years, there has been an increased focus on the role of cognitive functioning in the development and maintenance of AN. Adults with AN show inefficiencies in cognitive functions such as flexibility and central coherence. Systematic neuropsychological examinations of patients with EO-AN are missing. Thirty children with EO-AN and 30 adolescents with AN, as well as 60 healthy controls (HC) underwent an extensive neuropsychological examination. ANOVAs with post hoc tests and explorative regression analyses were conducted. Patients with EO-AN (mean age = 2.17 ± 1.57 years) showed no significant differences in flexibility, inhibition, planning, central coherence, visuospatial short- and long-term memory or recognition in comparison to HC (mean age = 11.62 ± 1.29 years). Performance of adolescents with AN (mean age = 15.93 ± 0.70 years) was not significantly different compared to HC (mean age = 16.20 ± 1.26 years). Explorative regression analyses revealed a significant interaction of age and group for flexibility (adjusted R 2  = 0.30, F = 17.85, p = 0.013, η p 2  = 0.32). Contrary to expectations, the current study could not confirm the presence of inefficient cognitive processing in children with EO-AN compared to HC. Nonetheless, the expected age-related improvement of flexibility might be disrupted in children and adolescents with AN. Longitudinal neuropsychological examinations are necessary to provide more information about the role of cognitive functioning in the development and maintenance of AN.

The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content.

PubMed

Almeida, Inês; van Asselen, Marieke; Castelo-Branco, Miguel

2013-09-01

In human cognition, most relevant stimuli, such as faces, are processed in central vision. However, it is widely believed that recognition of relevant stimuli (e.g. threatening animal faces) at peripheral locations is also important due to their survival value. Moreover, task instructions have been shown to modulate brain regions involved in threat recognition (e.g. the amygdala). In this respect it is also controversial whether tasks requiring explicit focus on stimulus threat content vs. implicit processing differently engage primitive subcortical structures involved in emotional appraisal. Here we have addressed the role of central vs. peripheral processing in the human amygdala using animal threatening vs. non-threatening face stimuli. First, a simple animal face recognition task with threatening and non-threatening animal faces, as well as non-face control stimuli, was employed in naïve subjects (implicit task). A subsequent task was then performed with the same stimulus categories (but different stimuli) in which subjects were told to explicitly detect threat signals. We found lateralized amygdala responses both to the spatial location of stimuli and to the threatening content of faces depending on the task performed: the right amygdala showed increased responses to central compared to left presented stimuli specifically during the threat detection task, while the left amygdala was better prone to discriminate threatening faces from non-facial displays during the animal face recognition task. Additionally, the right amygdala responded to faces during the threat detection task but only when centrally presented. Moreover, we have found no evidence for superior responses of the amygdala to peripheral stimuli. Importantly, we have found that striatal regions activate differentially depending on peripheral vs. central processing of threatening faces. Accordingly, peripheral processing of these stimuli activated more strongly the putaminal region, while central processing engaged mainly the caudate nucleus. We conclude that the human amygdala has a central bias for face stimuli, and that visual processing recruits different striatal regions, putaminal or caudate based, depending on the task and on whether peripheral or central visual processing is involved. © 2013 Elsevier Ltd. All rights reserved.

Distributed trace using central performance counter memory

DOEpatents

Satterfield, David L; Sexton, James C

2013-10-22

A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

Distributed trace using central performance counter memory

DOEpatents

Satterfield, David L.; Sexton, James C.

2013-01-22

A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

Discovery, Controls, and Hazards of Widespread Deep-Seated Gravitational Slope Deformation in the Etsumi Mountains, Central Japan

NASA Astrophysics Data System (ADS)

Kaneda, Heitaro; Kono, Taiyo

2017-12-01

Deep-seated gravitational slope deformation (DSGSD) is a largely unnoticed but important long-term mass wasting process that may result in catastrophic failure of mountain slopes. Manifested by small topographic irregularities such as ridge-parallel scarps and linear depressions, it has been predominantly reported in alpine landscapes above timber lines. On the basis of area-wide high-resolution topographic data acquired by light detection and ranging (lidar) surveys, we here show that 96% of existing gravitational scarps have been hidden under forest canopies in the Etsumi Mountains, central Japan. The scarps are surprisingly widespread over the mountains with a mean line density of as large as 0.87 km/km2. Our analyses of the scarp distribution suggest that uphill-facing scarps are primary geomorphic signals of DSGSD with a destabilized rock mass larger than 105 m2, whereas downhill-facing scarps principally occur in response to more localized slope deformation. In terms of controls, topography is by far the most influential factor in triggering and promoting DSGSD. Despite the M 7.5 earthquake in 1891, impact of large local earthquakes proves to be not very strong. Comparison with preexisting landslide maps further suggests that DSGSD and large-scale landslides are not different slope processes but represent different stages of the same process. Our results highlight limitations of aerial-photograph interpretation in forest-covered mountains and the need for lidar-assisted mapping for deeper understanding of this long-term process and interactions between surface and tectonic processes.

Precipitation composition and wet deposition temporal pattern in Central Serbia for the period from 1998 to 2004.

PubMed

Golobocanin, D; Zujić, A; Milenković, A; Miljević, N

2008-07-01

Bulk samples collected on a daily basis at three principal meteorological stations in central Serbia were analyzed on chloride (Cl(-)), nitrate (NO(3)(-)), sulfate (SO(4)(2-)), sodium (Na(+)), ammonium (NH(4)(+)), potassium (K(+)), calcium (Ca(2+)), and magnesium (Mg(2+)) in addition to precipitation amount, pH and conductivity measurements over the period 1998-2004. The data were subjected to variety of analyses (linear regression, principal component analysis, time series analysis) to characterize precipitation chemistry in the study area. The most abundant ion was SO(2-)(4) with annual volume weighted mean concentration of 242 microeq L(-1). Neutralization of precipitation acidity occurs both as a result of the dissolution of alkaline compounds containing Ca(2+), Mg(2+), and K(+) as well as the absorption of ammonia. The ratio of SO(4)(2-)/NO(3)(-) was above 5, which indicated that the combustion process of low-grade domestic lignite for electricity generation from coal-fired thermal power plants was the main source of pollution in the investigated area. A considerable mean annual bulk wet deposition of SO(4)-S determined by precipitation amount and concentrations of sulfate in the precipitation was calculated to be 12-35 kg ha(-1).

Optimization of Hydrothermal and Diluted Acid Pretreatments of Tunisian Luffa cylindrica (L.) Fibers for 2G Bioethanol Production through the Cubic Central Composite Experimental Design CCD: Response Surface Methodology

PubMed Central

Ziadi, Manel; Ben Hassen-Trabelsi, Aida; Mekni, Sabrine; Aïssi, Balkiss; Alaya, Marwen; Bergaoui, Latifa; Hamdi, Moktar

2017-01-01

This paper opens up a new issue dealing with Luffa cylindrica (LC) lignocellulosic biomass recovery in order to produce 2G bioethanol. LC fibers are composed of three principal fractions, namely, α-cellulose (45.80%  ± 1.3), hemicelluloses (20.76%  ± 0.3), and lignins (13.15%  ± 0.6). The optimization of LC fibers hydrothermal and diluted acid pretreatments duration and temperature were achieved through the cubic central composite experimental design CCD. The pretreatments optimization was monitored via the determination of reducing sugars. Then, the 2G bioethanol process feasibility was tested by means of three successive steps, namely, LC fibers hydrothermal pretreatment performed at 96°C during 54 minutes, enzymatic saccharification carried out by means of a commercial enzyme AP2, and the alcoholic fermentation fulfilled with Saccharomyces cerevisiae. LC fibers hydrothermal pretreatment liberated 33.55 g/kg of reducing sugars. Enzymatic hydrolysis allowed achieving 59.4 g/kg of reducing sugars. The conversion yield of reducing sugar to ethanol was 88.66%. After the distillation step, concentration of ethanol was 1.58% with a volumetric yield about 70%. PMID:28243606

Bipartite graphs as models of population structures in evolutionary multiplayer games.

PubMed

Peña, Jorge; Rochat, Yannick

2012-01-01

By combining evolutionary game theory and graph theory, "games on graphs" study the evolutionary dynamics of frequency-dependent selection in population structures modeled as geographical or social networks. Networks are usually represented by means of unipartite graphs, and social interactions by two-person games such as the famous prisoner's dilemma. Unipartite graphs have also been used for modeling interactions going beyond pairwise interactions. In this paper, we argue that bipartite graphs are a better alternative to unipartite graphs for describing population structures in evolutionary multiplayer games. To illustrate this point, we make use of bipartite graphs to investigate, by means of computer simulations, the evolution of cooperation under the conventional and the distributed N-person prisoner's dilemma. We show that several implicit assumptions arising from the standard approach based on unipartite graphs (such as the definition of replacement neighborhoods, the intertwining of individual and group diversity, and the large overlap of interaction neighborhoods) can have a large impact on the resulting evolutionary dynamics. Our work provides a clear example of the importance of construction procedures in games on graphs, of the suitability of bigraphs and hypergraphs for computational modeling, and of the importance of concepts from social network analysis such as centrality, centralization and bipartite clustering for the understanding of dynamical processes occurring on networked population structures.

Transfusion practice in Helsinki University Central Hospital: an analysis of diagnosis-related groups (DRG).

PubMed

Syrjälä, M T; Kytöniemi, I; Mikkolainen, K; Ranimo, J; Lauharanta, J

2001-12-01

Transfusion data combined with data automatically recorded in hospital databases provides an outstanding tool for blood utilization reporting. When the reporting is performed with an online analytical processing (OLAP) tool, real time reporting can be provided to blood subscribers. When this data is combined with a common patient classification system, Diagnosis-Related Groups (DRG), it is possible to produce statistical results, that are similar in different institutions and may provide a means for international transfusion bench-marking and cost comparison. We use a DRG classification to describe the transfusion practice in Helsinki University Central Hospital. The key indicators include the percentage of transfused patients, the number of transfused units and costs in different DRG groups, as well as transfusion rates per DRG weighted treatment episodes. Ninety-three per cent of all transfusions could be classified into different DRGs. The largest blood-using DRG group was acute adult leukaemia (DRG 473), which accounted for 10.4% of all transfusion costs. The 13 largest blood consuming DRGs accounted for half the total costs in 1998. Currently, there is a lack of an internationally accepted standardized way to report institutional or national transfusion practices. DRG-based transfusion reporting might serve as a means for transfusion benchmarking and thus aid studies of variations in transfusion practice.

Barking up the wrong tree? Lexical ambiguity resolution in children with language impairments and autistic spectrum disorders.

PubMed

Norbury, Courtenay Frazier

2005-02-01

Lexical ambiguity resolution was investigated in 9- to 17-year-olds with language impairment (LI, n=20), autistic spectrum disorder (ASD) plus language impairment (ALI, n=28), ASD and verbal abilities within the normal range (ASO, n=20), and typically developing children (TD, n=28). Experiment 1 investigated knowledge of dominant and subordinate meanings of ambiguous words. The LI and ALI groups knew fewer subordinate meanings than did the ASO and TD groups. Experiment 2 used a modified version of the paradigm to investigate contextual facilitation and suppression of irrelevant meanings. All groups demonstrated contextual facilitation, responding quickly and more accurately to words following a biased context. However, children with ALI and LI did not use context as efficiently as did their peers without language deficit. Furthermore, for the LI and ALI groups, errors in the suppression condition reflected poor contextual processing. These findings challenge the assumptions of weak central coherence theory and demonstrate the need for stringent language controls in the study of autistic cognition.

Stable statistical representations facilitate visual search.

PubMed

Corbett, Jennifer E; Melcher, David

2014-10-01

Observers represent the average properties of object ensembles even when they cannot identify individual elements. To investigate the functional role of ensemble statistics, we examined how modulating statistical stability affects visual search. We varied the mean and/or individual sizes of an array of Gabor patches while observers searched for a tilted target. In "stable" blocks, the mean and/or local sizes of the Gabors were constant over successive displays, whereas in "unstable" baseline blocks they changed from trial to trial. Although there was no relationship between the context and the spatial location of the target, observers found targets faster (as indexed by faster correct responses and fewer saccades) as the global mean size became stable over several displays. Building statistical stability also facilitated scanning the scene, as measured by larger saccadic amplitudes, faster saccadic reaction times, and shorter fixation durations. These findings suggest a central role for peripheral visual information, creating context to free resources for detailed processing of salient targets and maintaining the illusion of visual stability.

Imaging Subsurface Structure of Central Zagros Zone/Iran Using Ambient Noise Tomography

NASA Astrophysics Data System (ADS)

Vahidravesh, Shaghayegh; Pakzad, Mehrdad, ,, Dr.; Hatami, Mohammad Reza, ,, Dr.

2017-04-01

The Central Zagros zone, of west Iran & east Iraq, is surrounded by many active faults (including Main Zagros Reversed Fault, Main Recent Fault, High Zagros Fault, Zagros Fold, & Thrust Belt). Recent studies show that cross-correlation of a long-term ambient seismic noise data recorded in station-pair, includes important information regarding empirical Green's functions (EGFs) between stations. Hence, ambient seismic noise carries valuable information of the wave propagation path (which can be extracted). The 2D model of surface waves (Rayleigh & Love) velocities for the studied area is obtained by seismic ambient noise tomography (ANT) method. Throughout this research, we use continuous records of all three vertical, radial, and tangential components (obtained by rotation) recorded by IRSC (Iranian Seismological Center) and IIEES (International Institute of Earthquake Engineering) networks for this area of interest. The IRSC & IIEES networks are equipped by SS-1 kinematics and Guralp CMG-3T sensors respectively. Data of 20 stations were used for 12 months from 2014/Nov. to 2015/Nov. The performed data processing is similar to the one, put into words in detail by Bensen et al. (2007) including the processed daily base data. Mean, trend, and instrument response were removed and the data were decimated to 5 sps (sample per second) to reduce the amount of storage space and computational time required. We then applied merge to handle data gaps. One-bit time-domain normalization was also applied to suppress the influence of instrument irregularities and earthquake signals followed by spectral (frequency-domain) normalization between 0.05-0.2 Hz (period 5-20 sec). After cross-correlation (processing step), we perform rms stacking (new approach of stacking) to stack many cross-correlation functions based on the highest energy in a time interval which we accordingly anticipate to receive Rayleigh & Love waves fundamental modes. To evaluate quality of the stacking process stability quantitatively, we calculate signal-to-noise ratio (SNR), defined as a ratio of the peak amplitude within a time window to the root-mean-square of noise trailing the signal arrival window (Bensen et al., 2007), for each cross-correlation. The cross-correlated time-series is equivalent to the Green's functions between pairs of receivers. We then apply multiple phase-matched filter method of Herrmann (2005) to measure the correct group velocity dispersion of the interferometric surface waves. Eventually, we apply fast marching surface wave tomography (FMST), the iterative nonlinear inversion package developed by Rawlinson, 2005, to extract the velocity model of shallow structure in Central Zagros zone /Iran.

Centralization of symptoms and lumbar range of motion in patients with low back pain.

PubMed

Bybee, Ronald F; Olsen, Denise L; Cantu-Boncser, Gloria; Allen, Heather Condie; Byars, Allyn

2009-05-01

This quasi-experimental repeated measures study examined the relationship between centralization of symptoms and lumbar flexion and extension range of motion (ROM) in patients with low back pain. Rapid and lasting changes in lumbar ROM have been noted with centralization of symptoms. However, no study has objectively measured the changes in lumbar ROM occurring with centralization. Forty-two adult subjects (mean age, 45.68 years; SD=15.76 years) with low back pain and associated lower extremity symptoms were followed by McKenzie trained physical therapists. Subjects' lumbar ROM was measured at the beginning and end of each patient visit by using double inclinometers, and pain location was documented. Subjects were grouped as 1) centralized, 2) centralizing, or 3) noncentralized for comparisons of symptom and ROM changes. Data were analyzed by using multivariate analysis of variance and one-way analysis of variance. Significance was set at 0.05. A significant difference was found between initial and final mean extension ROM in the centralized and centralizing groups (p=0.003). No significant difference was found in the noncentralized group (p<0.05). Subjects (n=23) who demonstrated a change in pain location during the initial visit also showed a significant (p<0.001) change in extension ROM, whereas patients with no change in pain location (n=19) did not (p=0.848). Lumbar extension ROM increased as centralization occurred.

Psychoimmuno-neuroendocrinology: An integrative approach to modern philosophy in medicine and psychology.

PubMed

Fedor-Freybergh, Peter G.

1999-01-01

The immune system is now seen to be closely integrated with other physiological circuits, such as the central nervous system (CNS) and the neuroendocrine system. There is also an increasing amount of evidence that this integrated circuit is bidirectional and both systems exert a reciprocal effect on each other. We have always stressed the interdisciplinary nature of the science where disciplines and sciences such as medicine, biochemistry, genetics, psychology, human ethology, etc. meet and undergo a process of "cross-fertilization." We also have stressed the indivisibility of the somatic and psychological processes in the indivisible continuum of human life from its very beginning and the inseparability of the development and functions of the central nervous system and the immunological and neuroendocrine processes. This transdisciplinary and integrative aspect of sciences and their entree in the twenty-first century is the true vision for our common efforts. Integration means also amalgamation, assimilation, blending, combining, incorporation, unification and harmony. This last mentioned, harmony, should be stressed and underlined specifically: a harmony between different views and approaches, between different methods and methodologies, different theories and practices. In order to undertake such a challenge, a new scientific theory and a common language is required, a language that would be understood across disciplines and would be able to assist in getting beyond semantic problems. The bridge between the immune system, neuroendocrinology and the rest of the central nervous system opens the gateway to more common understanding and acceptance across the disciplines. It is an umbrella for the endeavor that unites various scientific fields in their attempt to elucidate the processes of experience involved from the earliest stages of human life. This integration does cross over the different disciplines and diagnostic systems. It attaches theoretical and applied fields, basic research and clinical experience throughout the whole continuity of human life from conception and onwards. Integrated Psychoimmuno-Neuroendocrinology represents a unique opportunity for the primary prevention of psychological, emotional and physical disorders.

Myoelectric signal processing for control of powered limb prostheses.

PubMed

Parker, P; Englehart, K; Hudgins, B

2006-12-01

Progress in myoelectric control technology has over the years been incremental, due in part to the alternating focus of the R&D between control methodology and device hardware. The technology has over the past 50 years or so moved from single muscle control of a single prosthesis function to muscle group activity control of multifunction prostheses. Central to these changes have been developments in the means of extracting information from the myoelectric signal. This paper gives an overview of the myoelectric signal processing challenge, a brief look at the challenge from an historical perspective, the state-of-the-art in myoelectric signal processing for prosthesis control, and an indication of where this field is heading. The paper demonstrates that considerable progress has been made in providing clients with useful and reliable myoelectric communication channels, and that exciting work and developments are on the horizon.

Variability of the institutional review board process within a national research network.

PubMed

Khan, Muhammad A; Barratt, Michelle S; Krugman, Scott D; Serwint, Janet R; Dumont-Driscoll, Marilyn

2014-06-01

To determine the variability of the institutional review board (IRB) process for a minimal risk multicenter study. Participants included 24 Continuity Research Network (CORNET) sites of the Academic Pediatric Association that participated in a cross-sectional study. Each site obtained individual institutional IRB approval. An anonymous questionnaire went to site investigators about the IRB process at their institution. Twenty-two of 24 sites (92%) responded. Preparation time ranged from 1 to 20 hours, mean of 7.1 hours. Individuals submitting ≤3 IRB applications/year required more time for completion than those submitting >3/year (P < .05). Thirteen of 22 (59%) study sites received approval with "exempt" status, and 6 (27%) approved as "expedited" studies. IRB experiences were highly variable across study sites. These findings indicate that multicenter research projects should anticipate barriers to timely study implementation. Improved IRB standardization or centralization for multicenter clinical studies would facilitate this type of practice-based clinical research.

Development of alternative data analysis techniques for improving the accuracy and specificity of natural resource inventories made with digital remote sensing data

NASA Technical Reports Server (NTRS)

Lillesand, T. M.; Meisner, D. E. (Principal Investigator)

1980-01-01

An investigation was conducted into ways to improve the involvement of state and local user personnel in the digital image analysis process by isolating those elements of the analysis process which require extensive involvement by field personnel and providing means for performing those activities apart from a computer facility. In this way, the analysis procedure can be converted from a centralized activity focused on a computer facility to a distributed activity in which users can interact with the data at the field office level or in the field itself. A general image processing software was developed on the University of Minnesota computer system (Control Data Cyber models 172 and 74). The use of color hardcopy image data as a primary medium in supervised training procedures was investigated and digital display equipment and a coordinate digitizer were procured.

The Feed Materials Program of the Manhattan Project: A Foundational Component of the Nuclear Weapons Complex

NASA Astrophysics Data System (ADS)

Reed, B. Cameron

2014-12-01

The feed materials program of the Manhattan Project was responsible for procuring uranium-bearing ores and materials and processing them into forms suitable for use as source materials for the Project's uranium-enrichment factories and plutonium-producing reactors. This aspect of the Manhattan Project has tended to be overlooked in comparison with the Project's more dramatic accomplishments, but was absolutely vital to the success of those endeavors: without appropriate raw materials and the means to process them, nuclear weapons and much of the subsequent cold war would never have come to pass. Drawing from information available in Manhattan Engineer District Documents, this paper examines the sources and processing of uranium-bearing materials used in making the first nuclear weapons and how the feed materials program became a central foundational component of the postwar nuclear weapons complex.

High-resolution eye tracking using V1 neuron activity

PubMed Central

McFarland, James M.; Bondy, Adrian G.; Cumming, Bruce G.; Butts, Daniel A.

2014-01-01

Studies of high-acuity visual cortical processing have been limited by the inability to track eye position with sufficient accuracy to precisely reconstruct the visual stimulus on the retina. As a result, studies on primary visual cortex (V1) have been performed almost entirely on neurons outside the high-resolution central portion of the visual field (the fovea). Here we describe a procedure for inferring eye position using multi-electrode array recordings from V1 coupled with nonlinear stimulus processing models. We show that this method can be used to infer eye position with one arc-minute accuracy – significantly better than conventional techniques. This allows for analysis of foveal stimulus processing, and provides a means to correct for eye-movement induced biases present even outside the fovea. This method could thus reveal critical insights into the role of eye movements in cortical coding, as well as their contribution to measures of cortical variability. PMID:25197783

Physiological mechanisms of thermoregulation in reptiles: a review.

PubMed

Seebacher, Frank; Franklin, Craig E

2005-11-01

The thermal dependence of biochemical reaction rates means that many animals regulate their body temperature so that fluctuations in body temperature are small compared to environmental temperature fluctuations. Thermoregulation is a complex process that involves sensing of the environment, and subsequent processing of the environmental information. We suggest that the physiological mechanisms that facilitate thermoregulation transcend phylogenetic boundaries. Reptiles are primarily used as model organisms for ecological and evolutionary research and, unlike in mammals, the physiological basis of many aspects in thermoregulation remains obscure. Here, we review recent research on regulation of body temperature, thermoreception, body temperature set-points, and cardiovascular control of heating and cooling in reptiles. The aim of this review is to place physiological thermoregulation of reptiles in a wider phylogenetic context. Future research on reptilian thermoregulation should focus on the pathways that connect peripheral sensing to central processing which will ultimately lead to the thermoregulatory response.

Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study.

PubMed

Westera, Liset; van Viegen, Tanja; Jeyarajah, Jenny; Azad, Azar; Bilsborough, Janine; van den Brink, Gijs R; Cremer, Jonathan; Danese, Silvio; D'Haens, Geert; Eckmann, Lars; Faubion, William; Filice, Melissa; Korf, Hannelie; McGovern, Dermot; Panes, Julian; Salas, Azucena; Sandborn, William J; Silverberg, Mark S; Smith, Michelle I; Vermeire, Severine; Vetrano, Stefania; Shackelton, Lisa M; Stitt, Larry; Jairath, Vipul; Levesque, Barrett G; Spencer, David M; Feagan, Brian G; Vande Casteele, Niels

2017-11-02

Flow cytometry (FC) aids in characterization of cellular and molecular factors involved in pathologic immune responses. Although FC has potential to facilitate early drug development in inflammatory bowel disease, interlaboratory variability limits its use in multicenter trials. Standardization of methods may address this limitation. We compared variability in FC-aided quantitation of T-cell responses across international laboratories using three analytical strategies. Peripheral blood mononuclear cells (PBMCs) were isolated from three healthy donors, stimulated with phorbol 12-myristate 13-acetate and ionomycin at a central laboratory, fixed, frozen, and shipped to seven international laboratories. Permeabilization and staining was performed in triplicate at each laboratory using a common protocol and centrally provided reagents. Gating was performed using local gating with a local strategy (LGLS), local gating with a central strategy (LGCS), and central gating (CG). Median cell percentages were calculated across triplicates and donors, and reported for each condition and strategy. The coefficient of variation (CV) was calculated across laboratories. Between-strategy comparisons were made using a two-way analysis of variance adjusting for donor. Mean interlaboratory CV ranged from 1.8 to 102.1% depending on cell population and gating strategy (LGLS, 4.4-102.1%; LGCS, 10.9-65.6%; CG, 1.8-20.9%). Mean interlaboratory CV differed significantly across strategies and was consistently lower with CG. Central gating was the only strategy with mean CVs consistently lower than 25%, which is a proposed standard for pharmacodynamic and exploratory biomarker assays.

Apparatus for and method of correcting for aberrations in a light beam

DOEpatents

Sawicki, Richard H.

1996-01-01

A technique for adjustably correcting for aberrations in a light beam is disclosed herein. This technique utilizes first means which defines a flat, circular light reflecting surface having opposite reinforced circumferential edges and a central post and which is resiliently distortable, to a limited extent, into different concave and/or convex curvatures, which may be Gaussian-like, about the central axis, and second means acting on the first means for adjustably distorting the light reflecting surface into a particular selected one of the different curvatures depending upon the aberrations to be corrected for and for fixedly maintaining the curvature selected. In the embodiment disclosed, the light reflecting surface is adjustably distorted into the selected curvature by application of particular axial moments to the central post on the opposite side from the light reflecting surface and lateral moments to the circumference of the reflecting surface.

Apparatus for and method of correcting for aberrations in a light beam

DOEpatents

Sawicki, R.H.

1996-09-17

A technique for adjustably correcting for aberrations in a light beam is disclosed herein. This technique utilizes first means which defines a flat, circular light reflecting surface having opposite reinforced circumferential edges and a central post and which is resiliently distortable, to a limited extent, into different concave and/or convex curvatures, which may be Gaussian-like, about the central axis, and second means acting on the first means for adjustably distorting the light reflecting surface into a particular selected one of the different curvatures depending upon the aberrations to be corrected for and for fixedly maintaining the curvature selected. In the embodiment disclosed, the light reflecting surface is adjustably distorted into the selected curvature by application of particular axial moments to the central post on the opposite side from the light reflecting surface and lateral moments to the circumference of the reflecting surface. 8 figs.

Brains creating stories of selves: the neural basis of autobiographical reasoning

PubMed Central

Cassol, Helena; Phillips, Christophe; Balteau, Evelyne; Salmon, Eric; Van der Linden, Martial

2014-01-01

Personal identity critically depends on the creation of stories about the self and one’s life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the construction of such narratives. During functional magnetic resonance imaging scanning, participants approached a set of personally significant memories in two different ways: in some trials, they remembered the concrete content of the events (autobiographical remembering), whereas in other trials they reflected on the broader meaning and implications of their memories (autobiographical reasoning). Relative to remembering, autobiographical reasoning recruited a left-lateralized network involved in conceptual processing [including the dorsal medial prefrontal cortex (MPFC), inferior frontal gyrus, middle temporal gyrus and angular gyrus]. The ventral MPFC—an area that may function to generate personal/affective meaning—was not consistently engaged during autobiographical reasoning across participants but, interestingly, the activity of this region was modulated by individual differences in interest and willingness to engage in self-reflection. These findings support the notion that autobiographical reasoning and the construction of personal narratives go beyond mere remembering in that they require deriving meaning and value from past experiences. PMID:23482628

Improving Building Construction Specifications in State and Local Governments

NASA Technical Reports Server (NTRS)

1980-01-01

State and local governments can benefit from master specifications systems that centralize data on all types of building materials, products, and processes. Most of these systems are organized according to the MASTERFORMAT system, which, along with guide specifications that require the insertion or deletion of standardized information, resulted from the specific needs of users and providers. For jurisdictions preparing their own specifications, staff time and cost are reduced. For those subcontracting the preparation, master specifications provide a means of evaluating the specifications submitted. Current management specification systems described include SPECINTACT, OMSPEC, MASTERPEC, and the NAVFAC, Corps of Engineers, and GSA guide specifications.

Spatial durbin error model for human development index in Province of Central Java.

NASA Astrophysics Data System (ADS)

Septiawan, A. R.; Handajani, S. S.; Martini, T. S.

2018-05-01

The Human Development Index (HDI) is an indicator used to measure success in building the quality of human life, explaining how people access development outcomes when earning income, health and education. Every year HDI in Central Java has improved to a better direction. In 2016, HDI in Central Java was 69.98 %, an increase of 0.49 % over the previous year. The objective of this study was to apply the spatial Durbin error model using angle weights queen contiguity to measure HDI in Central Java Province. Spatial Durbin error model is used because the model overcomes the spatial effect of errors and the effects of spatial depedency on the independent variable. Factors there use is life expectancy, mean years of schooling, expected years of schooling, and purchasing power parity. Based on the result of research, we get spatial Durbin error model for HDI in Central Java with influencing factors are life expectancy, mean years of schooling, expected years of schooling, and purchasing power parity.

Central localization of plasticity involved in appetitive conditioning in Lymnaea

PubMed Central

Straub, Volko A.; Styles, Benjamin J.; Ireland, Julie S.; O'Shea, Michael; Benjamin, Paul R.

2004-01-01

Learning to associate a conditioned (CS) and unconditioned stimulus (US) results in changes in the processing of CS information. Here, we address directly the question whether chemical appetitive conditioning of Lymnaea feeding behavior involves changes in the peripheral and/or central processing of the CS by using extracellular recording techniques to monitor neuronal activity at two stages of the sensory processing pathway. Our data show that appetitive conditioning does not affect significantly the overall CS response of afferent nerves connecting chemosensory structures in the lips and tentacles to the central nervous system (CNS). In contrast, neuronal output from the cerebral ganglia, which represent the first central processing stage for chemosensory information, is enhanced significantly in response to the CS after appetitive conditioning. This demonstrates that chemical appetitive conditioning in Lymnaea affects the central, but not the peripheral processing of chemosensory information. It also identifies the cerebral ganglia of Lymnaea as an important site for neuronal plasticity and forms the basis for detailed cellular studies of neuronal plasticity. PMID:15537733

Laws of Large Numbers and Langevin Approximations for Stochastic Neural Field Equations

PubMed Central

2013-01-01

In this study, we consider limit theorems for microscopic stochastic models of neural fields. We show that the Wilson–Cowan equation can be obtained as the limit in uniform convergence on compacts in probability for a sequence of microscopic models when the number of neuron populations distributed in space and the number of neurons per population tend to infinity. This result also allows to obtain limits for qualitatively different stochastic convergence concepts, e.g., convergence in the mean. Further, we present a central limit theorem for the martingale part of the microscopic models which, suitably re-scaled, converges to a centred Gaussian process with independent increments. These two results provide the basis for presenting the neural field Langevin equation, a stochastic differential equation taking values in a Hilbert space, which is the infinite-dimensional analogue of the chemical Langevin equation in the present setting. On a technical level, we apply recently developed law of large numbers and central limit theorems for piecewise deterministic processes taking values in Hilbert spaces to a master equation formulation of stochastic neuronal network models. These theorems are valid for processes taking values in Hilbert spaces, and by this are able to incorporate spatial structures of the underlying model. Mathematics Subject Classification (2000): 60F05, 60J25, 60J75, 92C20. PMID:23343328

Three alternative structural configurations for phlebotomy: a comparison of effectiveness.

PubMed

Mannion, Heidi; Nadder, Teresa

2007-01-01

This study was designed to compare the effectiveness of three alternative structural configurations for inpatient phlebotomy. It was hypothesized that decentralized was less effective when compared to centralized inpatient phlebotomy. A non-experimental prospective survey design was conducted at the institution level. Laboratory managers completed an organizational survey and collected data on inpatient blood specimens during a 30-day data collection period. A random sample (n=31) of hospitals with onsite laboratories in the United States was selected from a database purchased from the Joint Commission on Accreditations of Healthcare Organizations (JCAHO). Effectiveness of the blood collection process was measured by the percentage of specimens rejected during the data collection period. Analysis of variance showed a statistically significant difference in the percentage of specimens rejected for centralized, hybrid, and decentralized phlebotomy configurations [F (2, 28) = 4.27, p = .02] with an effect size of .23. Post-hoc comparison using Tukey's HSD indicated that mean percentage of specimens rejected for centralized phlebotomy (M = .045, SD = 0.36) was significantly different from the decentralized configuration (M = 1.42, SD = 0.92, p = .03). found to be more effective when compared to the decentralized configuration.

Reduction in Central Line-Associated Bloodstream Infection Rates After Implementations of Infection Control Measures at a Level 3 Neonatal Intensive Care Unit.

PubMed

Dumpa, Vikramaditya; Adler, Bonny; Allen, Delena; Bowman, Deborah; Gram, Amy; Ford, Pat; Sannoh, Sulaiman

2016-01-01

Advances in neonatology led to survival of micro-preemies, who need central lines. Central line-associated bloodstream infection (CLABSI) causes prolonged hospitalization, morbidities, and mortality. Health care team education decreases CLABSIs. The objective was to decrease CLABSIs using evidence-based measures. The retrospective review compared CLABSI incidence during and after changes in catheter care. In April 2011, intravenous (IV) tubing changed from Interlink to Clearlink; IV tubing changing interval increased from 24 to 72 hours. CLABSIs increased. The following measures were implemented: July 2011, reeducation of neonatal intensive care staff on Clearlink; August 2011, IV tubing changing interval returned to 24 hours; September 2011, changed from Clearlink back to Interlink; November 2011, review of entire IV process and in-service on hand hygiene; December 2011, competencies on IV access for all nurses. CLABSIs were compared during and after interventions. Means were compared using the t test and ratios using the χ(2) test; P <.05. CLABSIs decreased from 4.4/1000 to 0/1000 catheter-days; P < .05. Evidence-based interventions reduced CLABSIs. © The Author(s) 2014.

Comparative study of representations of professional autonomy produced by first and last-period undergraduate nursing students 1

PubMed Central

dos Santos, Érick Igor; Gomes, Antonio Marcos Tosoli; Marques, Sergio Corrêa; Ramos, Raquel de Souza; da Silva, Aline Cerqueira Santos Santana; de Oliveira, Francimar Tinoco

2017-01-01

ABSTRACT Objective: to compare the social representations of professional nurse autonomy produced by first and last-period undergraduate nursing students. Method: qualitative, descriptive and exploratory study, based on the structural approach of social representations, the Central Core Theory, carried out with 171 students from three federal public universities, using the free association technique on the object “professional nurse autonomy”. The data were submitted to EVOC 2005 software and to similarity analysis. Results: care was the central core of the representational structure identified among the students of the first period. Among last-period students, knowledge stood out as a core element. The term responsibility was identified as common to both central cores. Conclusion: regarding professional autonomy, the results point to an overlapping process of the reified and consensual universes during the undergraduate course. However, responsibility, inherent in the profession, remains cross-sectional. For the first period students, autonomy is resignified in a practical and attitudinal way, whereas for the last period students, the knowledge acquired stimulates them to assign meaning to professional autonomy with a cognitive and attitudinal representation. The data can support the use of innovative teaching practices in nursing undergraduate courses.

[Decentralized outpatient teams in community-based psychiatric care: comparison of two Bavarian rural catchment areas].

PubMed

Valdes-Stauber, J; Putzhammer, A; Kilian, R

2014-05-01

Psychiatric outpatient clinics (PIAs) are an indispensable care service for crisis intervention and multidisciplinary treatment of people suffering from severe and persistent mental disorders. The decentralization of outpatient clinics can be understood as a further step in the deinstitutionalization process. This cross-sectional study (n=1,663) compared the central outpatient clinic with the decentralized teams for the year 2010 by means of analyses of variance, χ(2)-tests and robust multivariate regression models. The longitudinal assessment (descriptively and by means of Prais-Winsten regression models for time series) was based on all hospitalizations for the two decentralized teams (n = 6,693) according to partial catchment areas for the time period 2002-2010 in order to examine trends after their installation in the year 2007. Decentralized teams were found to be similar with respect to the care profile but cared for relatively more patients suffering from dementia, addictive and mood disorders but not for those suffering from schizophrenia and personality disorders. Decentralized teams showed less outpatient care costs as well as psychopharmacological expenses but a lower contact frequency than the central outpatient clinic. Total expenses for psychiatric care were not significantly different and assessed hospitalization variables (e.g. total number of annual admissions, cumulative length of inpatient-stay and annual hospitalizations per patient) changed slightly 3 years after installation of the decentralized teams. The number of admissions of people suffering from schizophrenia decreased whereas those for mood and stress disorders increased. Decentralized outpatient teams seemed to reach patients in rural regions who previously were not reached by the central outpatient clinic. Economic figures indicate advantages for the installation of such teams because care expenses are not higher than for patients treated in centralized outpatient clinics and because hospitalization figures for the whole catchment area did not increase.

Arms Transfers to Venezuela: A Comparative and Critical Analysis of the Acquisition Process (1980-1996).

DTIC Science & Technology

1999-03-01

Budget (Oficina Central de Presupuesto [OCEPRE]), which is the presidential agency with overall responsibility to formulate the national budget...Budget (Oficina Central de Presupuesto OCEPRE), and they receive a special treatment in the Venezuelan Budgetary process. The OCEPRE is the...the Central Office of Budget (Oficina Central de Presupuesto , OCEPRE). This occurs when funds for weapons acquisitions come from the ordinary budget

Linear mass actuator

NASA Technical Reports Server (NTRS)

Holloway, Sidney E., III (Inventor); Crossley, Edward A., Jr. (Inventor); Jones, Irby W. (Inventor); Miller, James B. (Inventor); Davis, C. Calvin (Inventor); Behun, Vaughn D. (Inventor); Goodrich, Lewis R., Sr. (Inventor)

1992-01-01

A linear mass actuator includes an upper housing and a lower housing connectable to each other and having a central passageway passing axially through a mass that is linearly movable in the central passageway. Rollers mounted in the upper and lower housings in frictional engagement with the mass translate the mass linearly in the central passageway and drive motors operatively coupled to the roller means, for rotating the rollers and driving the mass axially in the central passageway.

Improving the Procurement of Information Technology Commodities

DTIC Science & Technology

1994-04-12

and 0 the federal government. Apply Electronic Data Interchange (EDI) to order processing at AVC. Implementing EDI at AVC and throughout the Air Force...ordering process by approximately 2 weeks. 4. Centralize the Central Order Processing Offices. By consolidating AVC and SSCs order processing responsibilities...Im plem entation ..................................................................................... 21 5. ORDER PROCESSING WITH EDI

Central Auditory Processing Disorders: Is It a Meaningful Construct or a Twentieth Century Unicorn?

ERIC Educational Resources Information Center

Kamhi, Alan G.; Beasley, Daniel S.

1985-01-01

The article demonstrates how professional and theoretical perspectives (including psycholinguistics, behaviorist, and information processing perspectives) significantly influence the manner in which central auditory processing is viewed, assessed, and remediated. (Author/CL)

Sr/Ca and Mg/Ca vital effects correlated with skeletal architecture in a scleractinian deep-sea coral and the role of Rayleigh fractionation

NASA Astrophysics Data System (ADS)

Gagnon, Alexander C.; Adkins, Jess F.; Fernandez, Diego P.; Robinson, Laura F.

2007-09-01

Deep-sea corals are a new tool in paleoceanography with the potential to provide century long records of deep ocean change at sub-decadal resolution. Complicating the reconstruction of past deep-sea temperatures, Mg/Ca and Sr/Ca paleothermometers in corals are also influenced by non-environmental factors, termed vital effects. To determine the magnitude, pattern and mechanism of vital effects we measure detailed collocated Sr/Ca and Mg/Ca ratios, using a combination of micromilling and isotope-dilution ICP-MS across skeletal features in recent samples of Desmophyllum dianthus, a scleractinian coral that grows in the near constant environment of the deep-sea. Sr/Ca variability across skeletal features is less than 5% (2σ relative standard deviation) and variability of Sr/Ca within the optically dense central band, composed of small and irregular aragonite crystals, is significantly less than the surrounding skeleton. The mean Sr/Ca of the central band, 10.6 ± 0.1 mmol/mol (2σ standard error), and that of the surrounding skeleton, 10.58±0.09 mmol/mol, are statistically similar, and agree well with the inorganic aragonite Sr/Ca-temperature relationship at the temperature of coral growth. In the central band, Mg/Ca is greater than 3 mmol/mol, more than twice that of the surrounding skeleton, a general result observed in the relative Mg/Ca ratios of D. dianthus collected from separate oceanographic locations. This large vital effect corresponds to a ˜ 10 °C signal, when calibrated via surface coral Mg/Ca-temperature relationships, and has the potential to complicate paleoreconstructions. Outside the central band, Mg/Ca ratios increase with decreasing Sr/Ca. We explain the correlated behavior of Mg/Ca and Sr/Ca outside the central band by Rayleigh fractionation from a closed pool, an explanation that has been proposed elsewhere, but which is tested in this study by a simple and general relationship. We constrain the initial solution and effective partition coefficients for a Rayleigh process consistent with our accurate Metal/Ca measurements. A process other than Rayleigh fractionation influences Mg in the central band and our data constrain a number of possible mechanisms for the precipitation of this aragonite. Understanding the process affecting tracer behavior during coral biomineralization can help us better interpret paleoproxies in biogenic carbonates and lead to an improved deep-sea paleothermometer.

Methodological considerations in the design and implementation of clinical trials.

PubMed

Cirrincione, Constance T; Lavoie Smith, Ellen M; Pang, Herbert

2014-02-01

To review study design issues related to clinical trials led by oncology nurses, with special attention to those conducted within the cooperative group setting; to emphasize the importance of the statistician's role in the process of clinical trials. Studies available at clinicaltrials.gov using experimental designs that have been published in peer-reviewed journals; cooperative group trials are highlighted. The clinical trial is a primary means to test intervention efficacy. A properly designed and powered study with clear and measurable objectives is as important as the intervention itself. Collaboration among the study team, including the statistician, is central in developing and conducting appropriately designed studies. For optimal results, collaboration is an ongoing process that should begin early on. Copyright © 2014 Elsevier Inc. All rights reserved.

Structural Priming: A Critical Review

PubMed Central

Pickering, Martin J.; Ferreira, Victor S.

2009-01-01

Repetition is a central phenomenon of behavior, and researchers make extensive use of it to illuminate psychological functioning. In the language sciences, a ubiquitous form of such repetition is structural priming, a tendency to repeat or better process a current sentence because of its structural similarity to a previously experienced (“prime”) sentence (Bock, 1986). The recent explosion of research in structural priming has made it the dominant means of investigating the processes involved in the production (and increasingly, comprehension) of complex expressions such as sentences. This review considers its implications for the representation of syntax and the mechanisms of production, comprehension, and their relationship. It then addresses the potential functions of structural priming, before turning to its implications for first language acquisition, bilingualism, and aphasia We close with theoretical and empirical recommendations for future investigations. PMID:18444704

Removal of antibiotic cloxacillin by means of electrochemical oxidation, TiO2 photocatalysis, and photo-Fenton processes: analysis of degradation pathways and effect of the water matrix on the elimination of antimicrobial activity.

PubMed

Serna-Galvis, Efraim A; Giraldo-Aguirre, Ana L; Silva-Agredo, Javier; Flórez-Acosta, Oscar A; Torres-Palma, Ricardo A

2017-03-01

This study evaluates the treatment of the antibiotic cloxacillin (CLX) in water by means of electrochemical oxidation, TiO 2 photocatalysis, and the photo-Fenton system. The three treatments completely removed cloxacillin and eliminated the residual antimicrobial activity from synthetic pharmaceutical wastewater containing the antibiotic, commercial excipients, and inorganic ions. However, significant differences in the degradation routes were found. In the photo-Fenton process, the hydroxyl radical was involved in the antibiotic removal, while in the TiO 2 photocatalysis process, the action of both the holes and the adsorbed hydroxyl radicals degraded the pollutant. In the electrochemical treatment (using a Ti/IrO 2 anode in sodium chloride as supporting electrolyte), oxidation via HClO played the main role in the removal of CLX. The analysis of initial by-products showed five different mechanistic pathways: oxidation of the thioether group, opening of the central β-lactam ring, breakdown of the secondary amide, hydroxylation of the aromatic ring, and decarboxylation. All the oxidation processes exhibited the three first pathways. Moreover, the aromatic ring hydroxylation was found in both photochemical treatments, while the decarboxylation of the pollutant was only observed in the TiO 2 photocatalysis process. As a consequence of the degradation routes and mechanistic pathways, the elimination of organic carbon was different. After 480 and 240 min, the TiO 2 photocatalysis and photo-Fenton processes achieved ∼45 and ∼15 % of mineralization, respectively. During the electrochemical treatment, 100 % of the organic carbon remained even after the antibiotic was treated four times the time needed to degrade it. In contrast, in all processes, a natural matrix (mineral water) did not considerably inhibit pollutant elimination. However, the presence of glucose in the water significantly affected the degradation of CLX by means of TiO 2 photocatalysis.

Expect the unexpected: a paradoxical effect of cue validity on the orienting of attention.

PubMed

Jollie, Ashley; Ivanoff, Jason; Webb, Nicole E; Jamieson, Andrew S

2016-10-01

Predictive central cues generate location-based expectancies, voluntary shifts of attention, and facilitate target processing. Often, location-based expectancies and voluntary attention are confounded in cueing tasks. Here we vary the predictability of central cues to determine whether they can evoke the inhibition of target processing in three go/no-go experiments. In the first experiment, the central cue was uninformative and did not predict the target's location. Importantly, these cues did not seem to affect target processing. In the second experiment, the central cue indicated the most or the least likely location of the target. Surprisingly, both types of cues facilitated target processing at the cued location. In the third experiment, the central cue predicted the most likely location of a no-go target, but it did not provide relevant information pertaining to the location of the go target. Again, the central cue facilitated processing of the go target. These results suggest that efforts to strategically allocate inhibition may be thwarted by the paradoxical monitoring of the cued location. The current findings highlight the need to further explore the relationship between location-based expectancies and spatial attention in cueing tasks.

Assessment of undiscovered continuous oil and gas resources in the Heath Formation, central Montana and western North Dakota, 2016

USGS Publications Warehouse

Drake, Ronald M.; Schenk, Christopher J.; Klett, Timothy R.; Le, Phuong A.; Leathers, Heidi M.; Brownfield, Michael E.; Finn, Thomas M.; Gaswirth, Stephanie B.; Marra, Kristen R.; Tennyson, Marilyn E.

2017-06-07

Using a geology-based assessment methodology, the U.S. Geological Survey estimated undiscovered, technically recoverable mean resources of 884 million barrels of oil and 106 billion cubic feet of gas in the North-Central Montana and Williston Basin Provinces of central Montana and western North Dakota.

Book Learning: Exploring the Meaning of Formal Education in Central Appalachia

ERIC Educational Resources Information Center

Jones, Janet B.

2013-01-01

In 2008 the school dropout rate in Central Appalachia was at 27% and the drug problem was epidemic. An investigation centered on a sample of Central Appalachian residents who had been discharged from the local outpatient clinic for opiate dependency revealed insights into their educational experiences and an understanding of drug dependency and…

9 CFR 93.422 - Import permit and declaration for ruminants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... regions of Central America or of the West Indies, the importer shall first apply for and obtain from APHIS...; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Central America and West Indies 9 § 93... paragraph (c) of § 93.423. 9 Importations from regions of Central America and the West Indies shall be...

The Case of Norway - Spectacular Renegades from Central Control

ERIC Educational Resources Information Center

Belding, Robert E.; Lane, Willard R.

1975-01-01

Education in Norway's far northlands is wonderfully diverse, even though local schools are governed by a national ministry of education. This article should shatter the myth that central control means bland homogenization. (Editor)

An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing

PubMed Central

Troup, Lucy J.; Bastidas, Stephanie; Nguyen, Maia T.; Andrzejewski, Jeremy A.; Bowers, Matthew; Nomi, Jason S.

2016-01-01

The effect of cannabis on emotional processing was investigated using event-related potential paradigms (ERPs). ERPs associated with emotional processing of cannabis users, and non-using controls, were recorded and compared during an implicit and explicit emotional expression recognition and empathy task. Comparisons in P3 component mean amplitudes were made between cannabis users and controls. Results showed a significant decrease in the P3 amplitude in cannabis users compared to controls. Specifically, cannabis users showed reduced P3 amplitudes for implicit compared to explicit processing over centro-parietal sites which reversed, and was enhanced, at fronto-central sites. Cannabis users also showed a decreased P3 to happy faces, with an increase to angry faces, compared to controls. These effects appear to increase with those participants that self-reported the highest levels of cannabis consumption. Those cannabis users with the greatest consumption rates showed the largest P3 deficits for explicit processing and negative emotions. These data suggest that there is a complex relationship between cannabis consumption and emotion processing that appears to be modulated by attention. PMID:26926868

Central load reduces peripheral processing: Evidence from incidental memory of background speech.

PubMed

Halin, Niklas; Marsh, John E; Sörqvist, Patrik

2015-12-01

Is there a trade-off between central (working memory) load and peripheral (perceptual) processing? To address this question, participants were requested to undertake an n-back task in one of two levels of central/cognitive load (i.e., 1-back or 2-back) in the presence of a to-be-ignored story presented via headphones. Participants were told to ignore the background story, but they were given a surprise memory test of what had been said in the background story, immediately after the n-back task was completed. Memory was poorer in the high central load (2-back) condition in comparison with the low central load (1-back) condition. Hence, when people compensate for higher central load, by increasing attentional engagement, peripheral processing is constrained. Moreover, participants with high working memory capacity (WMC) - with a superior ability for attentional engagement - remembered less of the background story, but only in the low central load condition. Taken together, peripheral processing - as indexed by incidental memory of background speech - is constrained when task engagement is high. © 2015 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Association between dairy and calcium intake and general and central obesity among female students.

PubMed

Bank, Sahar Saraf; Ghanjali, Naeimeh; Ghalaeh, Reihaneh Seyyed; Azadbakht, Leila

2013-01-01

Nowadays, obesity is considered a worldwide problem. Although genetics is one of the factors associated with obesity, its predisposing factors include nutritional and environmental factors. Several studies have addressed the relationship between nutritional factors and general and central adiposity. Therefore, the purpose of this study was to determine the relationship between the consumption of dairy products and prevalence of obesity and central obesity in young female university students at the Isfahan University of Medical Sciences. This cross-sectional study was conducted on 236 healthy female university students in the age range of 18 and 30 years who were selected randomly from among the students at the Isfahan University of Medical Sciences, Iran. A previously validated semiquantitative food questionnaire was used to assess their entire dietary component intake. Physical activity was evaluated by recording daily physical activities. The prevalence of obesity, central adiposity, and excess weight was 1.7, 0.9, and 8.1%, respectively. The mean values of body mass index (BMI) and waist circumference were 21.54 kg/m(2) and 70.37 cm, respectively. Moreover, the mean value of dairy product consumption was 444.24 g/day. The results showed no significant relationship between dairy or calcium intake and weight and waist circumference as well as prevalence of obesity, central adiposity, and excess weight (P>0.05). There was no significant relationship between the consumption of dairy products and calcium intake and excess weight, obesity, and central adiposity among female university students. However, this study is important in that the prevalence of obesity, central adiposity, and excess weight along with the mean values of BMI and waist circumference are reported.

Influence of macular pigment optical density spatial distribution on intraocular scatter.

PubMed

Putnam, Christopher M; Bland, Pauline J; Bassi, Carl J

This study evaluated the summed measures of macular pigment optical density (MPOD) spatial distribution and their effects on intraocular scatter using a commercially available device (C-Quant, Oculus, USA). A customized heterochromatic flicker photometer (cHFP) device was used to measure MPOD spatial distribution across the central 16° using a 1° stimulus. MPOD was calculated as a discrete measure and summed measures across the central 1°, 3.3°, 10° and 16° diameters. Intraocular scatter was determined as a mean of 5 trials in which reliability and repeatability measures were met using the C-Quant. MPOD spatial distribution maps were constructed and the effects of both discrete and summed values on intraocular scatter were examined. Spatial mapping identified mean values for discrete MPOD [0.32 (s.d.=0.08)], MPOD summed across central 1° [0.37 (s.d.=0.11)], MPOD summed across central 3.3° [0.85 (s.d.=0.20)], MPOD summed across central 10° [1.60 (s.d.=0.35)] and MPOD summed across central 16° [1.78 (s.d.=0.39)]. Mean intraocular scatter was 0.83 (s.d.=0.16) log units. While there were consistent trends for an inverse relationship between MPOD and scatter, these relationships were not statistically significant. Correlations between the highest and lowest quartiles of MPOD within the central 1° were near significance. While there was an overall trend of decreased intraocular forward scatter with increased MPOD consistent with selective short wavelength visible light attenuation, neither discrete nor summed values of MPOD significantly influence intraocular scatter as measured by the C-Quant device. Published by Elsevier España, S.L.U.

Association between dairy and calcium intake and general and central obesity among female students

PubMed Central

Bank, Sahar Saraf; Ghanjali, Naeimeh; Ghalaeh, Reihaneh Seyyed; Azadbakht, Leila

2013-01-01

Background: Nowadays, obesity is considered a worldwide problem. Although genetics is one of the factors associated with obesity, its predisposing factors include nutritional and environmental factors. Several studies have addressed the relationship between nutritional factors and general and central adiposity. Therefore, the purpose of this study was to determine the relationship between the consumption of dairy products and prevalence of obesity and central obesity in young female university students at the Isfahan University of Medical Sciences. Materials and Methods: This cross-sectional study was conducted on 236 healthy female university students in the age range of 18 and 30 years who were selected randomly from among the students at the Isfahan University of Medical Sciences, Iran. A previously validated semiquantitative food questionnaire was used to assess their entire dietary component intake. Physical activity was evaluated by recording daily physical activities. Findings: The prevalence of obesity, central adiposity, and excess weight was 1.7, 0.9, and 8.1%, respectively. The mean values of body mass index (BMI) and waist circumference were 21.54 kg/m2 and 70.37 cm, respectively. Moreover, the mean value of dairy product consumption was 444.24 g/day. The results showed no significant relationship between dairy or calcium intake and weight and waist circumference as well as prevalence of obesity, central adiposity, and excess weight (P>0.05). Conclusion: There was no significant relationship between the consumption of dairy products and calcium intake and excess weight, obesity, and central adiposity among female university students. However, this study is important in that the prevalence of obesity, central adiposity, and excess weight along with the mean values of BMI and waist circumference are reported. PMID:24083266

The research of new type stratified water injection process intelligent measurement technology

NASA Astrophysics Data System (ADS)

Zhao, Xin

2017-10-01

To meet the needs of injection and development of Daqing Oilfield, the injection of oil from the early stage of general water injection to the subdivision of water is the purpose of improving the utilization degree and the qualified rate of water injection, improving the performance of water injection column and the matching process. Sets of suitable for high water content of the effective water injection technology supporting technology. New layered water injection technology intelligent measurement technology will be more information testing and flow control combined into a unified whole, long-term automatic monitoring of the work of the various sections, in the custom The process has the characteristics of "multi-layer synchronous measurement, continuous monitoring of process parameters, centralized admission data", which can meet the requirement of subdivision water injection, but also realize the automatic synchronization measurement of each interval, greatly improve the efficiency of tiered injection wells to provide a new means for the remaining oil potential.

Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory.

PubMed

Scholz-Kornehl, Sabrina; Schwärzel, Martin

2016-07-27

Dopamine is central to reinforcement processing and exerts this function in species ranging from humans to fruit flies. It can do so via two different types of receptors (i.e., D1 or D2) that mediate either augmentation or abatement of cellular cAMP levels. Whereas D1 receptors are known to contribute to Drosophila aversive odor learning per se, we here show that D2 receptors are specific for support of a consolidated form of odor memory known as anesthesia-resistant memory. By means of genetic mosaicism, we localize this function to Kenyon cells, the mushroom body intrinsic neurons, as well as GABAergic APL neurons and local interneurons of the antennal lobes, suggesting that consolidated anesthesia-resistant memory requires widespread dopaminergic modulation within the olfactory circuit. Additionally, dopaminergic neurons themselves require D2R, suggesting a critical role in dopamine release via its recognized autoreceptor function. Considering the dual role of dopamine in balancing memory acquisition (proactive function of dopamine) and its "forgetting" (retroactive function of dopamine), our analysis suggests D2R as central player of either process. Dopamine provides different information; while it mediates reinforcement during the learning act (proactive function), it balances memory performance between two antithetic processes thereafter (retroactive function) (i.e., forgetting and augmentation). Such bidirectional design can also be found at level of dopamine receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels. Here, we report that consolidated anesthesia-resistant memory (ARM), but not other concomitant memory phases, are sensitive to bidirectional dopaminergic signals. By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM. Copyright © 2016 the authors 0270-6474/16/367936-10$15.00/0.

CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.

PubMed

Laíns, Inês; Talcott, Katherine E; Santos, Ana R; Marques, João H; Gil, Pedro; Gil, João; Figueira, João; Husain, Deeba; Kim, Ivana K; Miller, Joan W; Silva, Rufino; Miller, John B

2018-01-01

To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography. A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Mean CT was calculated as the mean value within the ETDRS grid, and central CT as the mean in the central 1 mm. Diabetic eyes were divided into four groups: no diabetic retinopathy (No DR), nonproliferative DR (NPDR), NPDR with diabetic macular edema (NPDR + DME), and proliferative DR (PDR). Multilevel mixed linear models were performed for analyses. The authors included 50 control and 160 diabetic eyes (n = 27 No DR, n = 51 NPDR, n = 61 NPDR + DME, and n = 21 PDR). Mean CT (ß = -42.9, P = 0.022) and central CT (ß = -50.2, P = 0.013) were statistically significantly thinner in PDR eyes compared with controls, even after adjusting for confounding factors. Controlling for age, DR eyes presented a significantly decreased central CT than diabetic eyes without retinopathy (β = -36.2, P = 0.009). Swept-source optical coherence tomography demonstrates a significant reduction of CT in PDR compared with controls. In the foveal region, the choroid appears to be thinner in DR eyes than in diabetic eyes without retinopathy.

Mercury distribution in ancient and modern sediments of northeastern Bering Sea

USGS Publications Warehouse

Nelson, C. Hans; Pierce, D.E.; Leong, K.W.; Wang, F.F.

1972-01-01

A reconnaissance of surface and subsurface sediments to a maximum depth of 244 feet below the sea floor shows that natural mercury anomalies from 0.2 to 1.3 ppm have been present in northeastern Bering Sea since early Pliocene. The anomalies and mean values are highest in modern beach (maximum 1.3 and mean 0.22 ppm Hg) and nearshore subsurface gravels (maximum 0.6 and mean .06 ppm Hg) along the highly mineralized Seward Peninsula and in organic rich silt (maximum 0.16 and mean 0.10 ppm Hg) throughout the region; the mean values are lowest in offshore sands (0.03 ppm Hg) . Although gold mining may be partially responsible for high mercury levels in the beaches near Nome, Alaska, equally high or greater concentrations of mercury occur in ancient glacial sediments immediately offshore (0.6 ppm) and in modern unpolluted beach sediments at Bluff (0.45 - 1.3 ppm); this indicates that the contamination effects of mining may be no greater than natural concentration processes in the Seward Peninsula region. The background content of mercury (0.03) throughout the central area of northeastern Bering Sea is similar to that elsewhere in the world. The low mean values (0.04 ppm) even immediately offshore from mercury-rich beaches, suggests that in the surface sediments of northeastern Bering Sea, the highest concentrations are limited to the beaches near mercury sources; occasionally, however, low mercury anomalies occur offshore in glacial drift derived from mercury source regions of Chukotka and Seward Peninsula and reworked by Pleistocene shoreline processes. The minimal values offshore may be attributable to beach entrapment of heavy minerals containing mercury and/or dilution effects of modern sedimentation.

Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia.

PubMed

Alloza, Clara; Bastin, Mark E; Cox, Simon R; Gibson, Jude; Duff, Barbara; Semple, Scott I; Whalley, Heather C; Lawrie, Stephen M

2017-12-01

Schizophrenia is a complex disorder that may be the result of aberrant connections between specific brain regions rather than focal brain abnormalities. Here, we investigate the relationships between brain structural connectivity as described by network analysis, intelligence, symptoms, and polygenic risk scores (PGRS) for schizophrenia in a group of patients with schizophrenia and a group of healthy controls. Recently, researchers have shown an interest in the role of high centrality networks in the disorder. However, the importance of non-central networks still remains unclear. Thus, we specifically examined network-averaged fractional anisotropy (mean edge weight) in central and non-central subnetworks. Connections with the highest betweenness centrality within the average network (>75% of centrality values) were selected to represent the central subnetwork. The remaining connections were assigned to the non-central subnetwork. Additionally, we calculated graph theory measures from the average network (connections that occur in at least 2/3 of participants). Density, strength, global efficiency, and clustering coefficient were significantly lower in patients compared with healthy controls for the average network (p FDR  < 0.05). All metrics across networks were significantly associated with intelligence (p FDR  < 0.05). There was a tendency towards significance for a correlation between intelligence and PGRS for schizophrenia (r = -0.508, p = 0.052) that was significantly mediated by central and non-central mean edge weight and every graph metric from the average network. These results are consistent with the hypothesis that intelligence deficits are associated with a genetic risk for schizophrenia, which is mediated via the disruption of distributed brain networks. Hum Brain Mapp 38:5919-5930, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Movement and Meaning-Making in Physical Education

ERIC Educational Resources Information Center

Brown, Trent D.

2008-01-01

In this paper I argue that the meaning of movement of which embodied knowing, somatic understanding and ecological subjectivity are central tenets, has not received due recognition in the current discourses of physical education. While the interest in the meaning and meaning-making of movement within the physical education discourse has existed…

Effect of a Quality Improvement Intervention With Daily Round Checklists, Goal Setting, and Clinician Prompting on Mortality of Critically Ill Patients: A Randomized Clinical Trial.

PubMed

Cavalcanti, Alexandre B; Bozza, Fernando Augusto; Machado, Flavia R; Salluh, Jorge I F; Campagnucci, Valquiria Pelisser; Vendramim, Patricia; Guimaraes, Helio Penna; Normilio-Silva, Karina; Damiani, Lucas Petri; Romano, Edson; Carrara, Fernanda; Lubarino Diniz de Souza, Juliana; Silva, Aline Reis; Ramos, Grazielle Viana; Teixeira, Cassiano; Brandão da Silva, Nilton; Chang, Chung-Chou H; Angus, Derek C; Berwanger, Otavio

2016-04-12

The effectiveness of checklists, daily goal assessments, and clinician prompts as quality improvement interventions in intensive care units (ICUs) is uncertain. To determine whether a multifaceted quality improvement intervention reduces the mortality of critically ill adults. This study had 2 phases. Phase 1 was an observational study to assess baseline data on work climate, care processes, and clinical outcomes, conducted between August 2013 and March 2014 in 118 Brazilian ICUs. Phase 2 was a cluster randomized trial conducted between April and November 2014 with the same ICUs. The first 60 admissions of longer than 48 hours per ICU were enrolled in each phase. Intensive care units were randomized to a quality improvement intervention, including a daily checklist and goal setting during multidisciplinary rounds with follow-up clinician prompting for 11 care processes, or to routine care. In-hospital mortality truncated at 60 days (primary outcome) was analyzed using a random-effects logistic regression model, adjusted for patients' severity and the ICU's baseline standardized mortality ratio. Exploratory secondary outcomes included adherence to care processes, safety climate, and clinical events. A total of 6877 patients (mean age, 59.7 years; 3218 [46.8%] women) were enrolled in the baseline (observational) phase and 6761 (mean age, 59.6 years; 3098 [45.8%] women) in the randomized phase, with 3327 patients enrolled in ICUs (n = 59) assigned to the intervention group and 3434 patients in ICUs (n = 59) assigned to routine care. There was no significant difference in in-hospital mortality between the intervention group and the usual care group, with 1096 deaths (32.9%) and 1196 deaths (34.8%), respectively (odds ratio, 1.02; 95% CI, 0.82-1.26; P = .88). Among 20 prespecified secondary outcomes not adjusted for multiple comparisons, 6 were significantly improved in the intervention group (use of low tidal volumes, avoidance of heavy sedation, use of central venous catheters, use of urinary catheters, perception of team work, and perception of patient safety climate), whereas there were no significant differences between the intervention group and the control group for 14 outcomes (ICU mortality, central line-associated bloodstream infection, ventilator-associated pneumonia, urinary tract infection, mean ventilator-free days, mean ICU length of stay, mean hospital length of stay, bed elevation to ≥30°, venous thromboembolism prophylaxis, diet administration, job satisfaction, stress reduction, perception of management, and perception of working conditions). Among critically ill patients treated in ICUs in Brazil, implementation of a multifaceted quality improvement intervention with daily checklists, goal setting, and clinician prompting did not reduce in-hospital mortality. clinicaltrials.gov Identifier: NCT01785966.

Variation in Size and Form between Left and Right Maxillary Central Incisor Teeth.

PubMed

Vadavadagi, Suneel V; Hombesh, M N; Choudhury, Gopal Krishna; Deshpande, Sumith; Anusha, C V; Murthy, D Kiran

2015-02-01

To compare the variation in size of left and right maxillary central incisors for male patients (using digital calipers of 0.01 mm accuracy). To compare the variation in size of left and right maxillary central incisors for female patients (using digital calipers of 0.01 mm accuracy). To find out the difference between the maxillary central incisors of men and women. Its clinical applicability if difference exists. A total of 70 dental students of PMNM Dental College and Hospital were selected. Of 70 dental students, 40 male and 30 female were selected. Impressions were made for all subjects, using irreversible hydrocolloid (Algitex, manufacturer DPI, Batch-T-8804) using perforated stock metal trays. The mesiodistal crown width and cervical width were measured for each incisor and recorded separately for left and right teeth. The length was measured for each incisor and recorded separately for left and right maxillary central incisor using digitec height caliper. The mean value of maximum crown length of maxillary left central incisor of male was greater in length compared with maxillary right central incisor. Mean value of maximum crown length for male patient right and left side was greater compared with maximum crown length of female patient. When compared the dimensions of teeth between two sex, male group shows larger values to female group.

Applicability of Berry's index in bite mark analysis

PubMed Central

Antony, Palathottungal Joseph; Pillai, Karthigakannan Subramanian; George, Giju Baby; Varghese, Thomas; Puthalath, Mohammed Shibin; Arakkal, Leena Johnson

2015-01-01

Objectives: This study attempts to highlight the usefulness of applying Berry's Index as an adjuvant to support and aid in bite analysis. Materials and Methods: This study was conducted among 100 students between the ages of 18–30 from Mar Baselios Dental Collage, Kothamangalam. Out of the 100 subjects, there were 50 males and 50 females. The data obtained was tabulated and analyzed using Statistical Package for Social Sciences, Version 16 (SPSS). Results: The mean value of the width of the upper central incisor for male and female was 0.7602 cm and 0.7765 cm respectively. The mean value of the bizygomatic width for male and female was 12.54 cm and 12.42 cm respectively. The correlation between the upper central incisor width and the bizygomatic width was inferred to have a good positive correlation with a value 0f 0.613. Pearson correlation coefficient with greater correlation between the upper central incisor width and the bizygomatic width in female patient (r = 0.678) compared with male patient (r = 0. 525). Conclusion: Berry's Index can be a useful adjuvant to bite analysis by providing a means of determining the facial proportions of an individual from the width of the central incisors. PMID:25709316

Glancing and Then Looking: On the Role of Body, Affect, and Meaning in Cognitive Control

PubMed Central

Su, Li; Bowman, Howard; Barnard, Philip

2011-01-01

In humans, there is a trade-off between the need to respond optimally to the salient environmental stimuli and the need to meet our long-term goals. This implies that a system of salience sensitive control exists, which trades task-directed processing off against monitoring and responding to potentially high salience stimuli that are irrelevant to the current task. Much cognitive control research has attempted to understand these mechanisms using non-affective stimuli. However, recent research has emphasized the importance of emotions, which are a major factor in the prioritization of competing stimuli and in directing attention. While relatively mature theories of cognitive control exist for non-affective settings, exactly how emotions modulate cognitive processes is less well understood. The attentional blink (AB) task is a useful experimental paradigm to reveal the dynamics of both cognitive and affective control in humans. Hence, we have developed the glance–look model, which has replicated a broad profile of data on the semantic AB task and characterized how attentional deployment is modulated by emotion. Taking inspiration from Barnard’s Interacting Cognitive Subsystems, the model relies on a distinction between two levels of meaning: implicational and propositional, which are supported by two corresponding mental subsystems: the glance and the look respectively. In our model, these two subsystems reflect the central engine of cognitive control and executive function. In particular, the interaction within the central engine dynamically establishes a task filter for salient stimuli using a neurobiologically inspired learning mechanism. In addition, the somatic contribution of emotional effects is modeled by a body-state subsystem. We argue that stimulus-driven interaction among these three subsystems governs the movement of control between them. The model also predicts attenuation effects and fringe awareness during the AB. PMID:22194729

Glancing and then looking: on the role of body, affect, and meaning in cognitive control.

PubMed

Su, Li; Bowman, Howard; Barnard, Philip

2011-01-01

In humans, there is a trade-off between the need to respond optimally to the salient environmental stimuli and the need to meet our long-term goals. This implies that a system of salience sensitive control exists, which trades task-directed processing off against monitoring and responding to potentially high salience stimuli that are irrelevant to the current task. Much cognitive control research has attempted to understand these mechanisms using non-affective stimuli. However, recent research has emphasized the importance of emotions, which are a major factor in the prioritization of competing stimuli and in directing attention. While relatively mature theories of cognitive control exist for non-affective settings, exactly how emotions modulate cognitive processes is less well understood. The attentional blink (AB) task is a useful experimental paradigm to reveal the dynamics of both cognitive and affective control in humans. Hence, we have developed the glance-look model, which has replicated a broad profile of data on the semantic AB task and characterized how attentional deployment is modulated by emotion. Taking inspiration from Barnard's Interacting Cognitive Subsystems, the model relies on a distinction between two levels of meaning: implicational and propositional, which are supported by two corresponding mental subsystems: the glance and the look respectively. In our model, these two subsystems reflect the central engine of cognitive control and executive function. In particular, the interaction within the central engine dynamically establishes a task filter for salient stimuli using a neurobiologically inspired learning mechanism. In addition, the somatic contribution of emotional effects is modeled by a body-state subsystem. We argue that stimulus-driven interaction among these three subsystems governs the movement of control between them. The model also predicts attenuation effects and fringe awareness during the AB.

The central zone has increased 68Ga-PSMA-11 uptake: "Mickey Mouse ears" can be hot on 68Ga-PSMA-11 PET.

PubMed

Pizzuto, Daniele A; Müller, Julian; Mühlematter, Urs; Rupp, Niels J; Töpfer, Antonia; Mortezavi, Ashkan; Nagel, Hannes; Kranzbühler, Benedikt; Eberli, Daniel; Burger, Irene A

2018-03-09

Given the good correlation between PSMA expression and intraglandular tumour aggressiveness based on immunohistochemistry, there is increasing interest in 68 Ga-PSMA-11 PET/MRI for staging prostate cancer (PCA). Therefore, accurate knowledge of prostate anatomy as well as normal distribution of PSMA within the prostate gland is becoming essential. The aim of this study was to investigate the physiological intraprostatic distribution of 68 Ga-PSMA-11. We retrospectively analysed all patients who underwent a staging 68 Ga-PSMA-11 PET/MRI scan between June 2016 and January 2018 for high-risk PCA, underwent radical prostatectomy in our institution, and gave written consent for further data analysis. In each patient, standardized volumes of interest (VOIs) were placed bilaterally in the central, transition and peripheral zones within the zonal anatomy according to T2 weighted sequences in the axial and coronal planes. VOIs were only placed if they were safely within healthy tissue without spillover from the PCA. SUV max and SUV mean were determined and their differences among the regions were assessed using the Wilcoxon signed-ranks test. Of 283 consecutive patients scanned with 68 Ga-PSMA-11 PET/MR, 31 were analysed. A total of 133 VOIs were placed, 46 in the central zone, 41 in the transition zone and 46 in the peripheral zone. Differences in SUV max between the central zone (mean 3.9 ± 0.58) and transition zone (mean 3.2 ± 0.59) and between the central zone and peripheral zone (mean 2.7 ± 0.54) were statistically significant (both p < 0.001). Our results suggest that higher 68 Ga-PSMA-11 accumulation in the central zone than in the transition and peripheral zones is normal, and leads to a pattern resembling "Mickey Mouse ears" on 68 Ga-PSMA-11 PET. This pattern could be helpful in avoiding false-positive interpretations of PET scans.

Efficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy.

PubMed

Abraham, Mary B; Rao, Shripada; Price, Glynis; Choong, Catherine S

2014-01-01

The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmopressin and the obligate high fluid intake with milk feeds lead to considerable risk of water intoxication and hyponatremia. To reduce this risk, thiazide diuretics, part of the treatment of nephrogenic DI, were used in conjunction with low renal solute feed and were effective in a single case series of neonatal central DI. We evaluated the efficacy of early treatment of neonatal central DI with hydrochlorothiazide with low solute feed and investigated the clinical indicators for transition to desmopressin during infancy. A retrospective chart review was conducted at Princess Margaret Hospital, Perth of neonates diagnosed with central DI and treated with hydrochlorothiazide, between 2007 and 2013. Four newborns were identified. Mean sNa and mean change in sNa with desmopressin and hydrochlorothiazide treatment were recorded along with episodes of hyponatremia and hypernatremia. Length and weight trajectories during the first 12 months were assessed. The mean change in sNa per day with hydrochlorothiazide and low renal solute feed was 2.5 - 3 mmol/L; on desmopressin treatment, the mean change in sNa was 6.8-7.9 mmol/L. There was one episode of symptomatic hyponatremia with intranasal desmopressin with no episodes of hyponatremia or hypernatremia during treatment with hydrochlorothiazide or following transition to oral desmopressin. Transition to oral desmopressin between 3 to 12 months of age was associated with good control of DI. Following introduction of solids, sNa remained stable but weight gain was slow. This improved following transition to desmopressin in one infant. Hydrochlorothiazide with low renal solute feed is a safe and effective treatment option in neonatal central DI. However, transition to desmopressin should be considered early in infancy following initiation of solids to facilitate growth.

Examining an online microbiology game as an effective tool for teaching the scientific process.

PubMed

Bowling, Kristi G; Klisch, Yvonne; Wang, Shu; Beier, Margaret

2013-01-01

This study investigates the effectiveness of the online Flash game Disease Defenders in producing knowledge gains for concepts related to the scientific process. Disease Defenders was specifically designed to model how the scientific process is central to a variety of disciplines and science careers. An additional question relates to the game's ability to shift attitudes toward science. Middle school classes from grades six to eight were assigned to the experimental group (n = 489) or control group (n = 367) and asked to participate in a three-session intervention. The sessions involved completing a pretest, a game play session, and taking a posttest. Students in the experimental group played Disease Defenders while students in the control group played an alternative science game. Results showed a significant increase in mean science knowledge scores for all grades in the experimental group, with sixth grade and seventh grade students gaining more knowledge than eighth grade students. Additionally, results showed a significant positive change in science attitudes only among sixth graders, who also rated their satisfaction with the game more favorably than students in higher grades. No differences in mean test scores were found between genders for science knowledge or science attitudes, suggesting that the game is equally effective for males and females.

48 CFR 252.225-7035 - Buy American-Free Trade Agreements-Balance of Payments Program Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

....1101(10)(iii), add the terms “South Caucasus/Central and South Asian (SC/CASA) state” and “South Caucasus/Central and South Asian (SC/CASA) state end product” in paragraph (a) and substitute the following..., South Caucasus/Central and South Asian (SC/CASA) state end product, and United States have the meanings...

Experimentally induced central sensitization in the cervical spine evokes postural stiffening strategies in healthy young adults.

PubMed

Huntley, Andrew H; Srbely, John Z; Zettel, John L

2015-02-01

Dysequilibrium of cervicogenic origin can result from pain and injury to cervical paraspinal tissues post-whiplash; however, the specific physiological mechanisms still remain unclear. Central sensitization is a neuradaptive process which has been clinically associated with conditions of chronic pain and hypersensitivity. Strong links have been demonstrated between pain hypersensitivity and postural deficits post-whiplash; however, the precise mechanisms are still poorly understood. The purpose of this study was to explore the mechanisms of cervicogenic disequilibrium by investigating the effect of experimentally induced central sensitization in the cervical spine on postural stability in young healthy adults. Sixteen healthy young adults (7 males (22.6±1.13 years) and 9 females (22±2.69 years)) performed 30-s full-tandem stance trials on an AMTI force plate under normal and centrally sensitized conditions. The primary outcome variables included the standard deviation of the center of pressure (COP) position in medio-lateral (M-L) and antero-posterior (A-P) directions; sway range of the COP in M-L and A-P directions and the mean power frequency (MPF) of the COP and horizontal ground shear forces. Variability and sway range of the COP decreased with experimental induction of central sensitization, accompanied by an increase in MPF of COP displacement in both M-L and A-P directions, suggesting an increase in postural stiffening post-sensitization versus non-sensitized controls. Future studies need to further explore this relationship in clinical (whiplash, chronic pain) populations. Copyright © 2015 Elsevier B.V. All rights reserved.

Central X-ray beam correction of radiographic acetabular cup measurement after THA: an experimental study.

PubMed

Schwarz, T; Weber, M; Wörner, M; Renkawitz, T; Grifka, J; Craiovan, B

2017-05-01

Accurate assessment of cup orientation on postoperative radiographs is essential for evaluating outcome after THA. However, accuracy is impeded by the deviation of the central X-ray beam in relation to the cup and the impossibility of measuring retroversion on standard pelvic radiographs. In an experimental trial, we built an artificial cup holder enabling the setting of different angles of anatomical anteversion and inclination. Twelve different cup orientations were investigated by three examiners. After comparing the two methods for radiographic measurement of the cup position developed by Lewinnek and Widmer, we showed how to differentiate between anteversion and retroversion in each cup position by using a second plane. To show the effect of the central beam offset on the cup, we X-rayed a defined cup position using a multidirectional central beam offset. According to Murray's definition of anteversion and inclination, we created a novel corrective procedure to balance measurement errors caused by deviation of the central beam. Measurement of the 12 different cup positions with the Lewinnek's method yielded a mean deviation of [Formula: see text] (95 % CI 1.3-2.3) from the original cup anteversion. The respective deviation with the Widmer/Liaw's method was [Formula: see text] (95 % CI 2.4-4.0). In each case, retroversion could be differentiated from anteversion with a second radiograph. Because of the multidirectional central beam offset ([Formula: see text] cm) from the acetabular cup in the cup holder ([Formula: see text] anteversion and [Formula: see text] inclination), the mean absolute difference for anteversion was [Formula: see text] (range [Formula: see text] to [Formula: see text] and [Formula: see text] (range [Formula: see text] to [Formula: see text] for inclination. The application of our novel mathematical correction of the central beam offset reduced deviation to a mean difference of [Formula: see text] for anteversion and [Formula: see text] for inclination. This novel calculation for central beam offset correction enables highly accurate measurement of the cup position.

Geochemistry of sediments in the Northern and Central Adriatic Sea

NASA Astrophysics Data System (ADS)

De Lazzari, A.; Rampazzo, G.; Pavoni, B.

2004-03-01

Major, minor and trace elements, loss of ignition, specific surface area, quantities of calcite and dolomite, qualitative mineralogical composition, grain-size distribution and organic micropollutants (PAH, PCB, DDT) were determined on surficial marine sediments sampled during the 1990 ASCOP (Adriatic Scientific Cooperative Program) cruise. Mineralogical composition and carbonate content of the samples were found to be comparable with data previously reported in the literature, whereas geochemical composition and distribution of major, minor and trace elements for samples in international waters and in the central basin have never been reported before. The large amount of information contained in the variables of different origin has been processed by means of a comprehensive approach which establishes the relations among the components through the mathematical-statistical calculation of principal components (factors). These account for the major part of data variance loosing only marginal parts of information and are independent from the units of measure. The sample descriptors concerning natural components and contamination load are discussed by means of a statistical model based on an R-mode Factor analysis calculating four significant factors which explain 86.8% of the total variance, and represent important relationships between grain size, mineralogy, geochemistry and organic micropollutants. A description and an interpretation of factor composition is discussed on the basis of pollution inputs, basin geology and hydrodynamics. The areal distribution of the factors showed that it is the fine grain-size fraction, with oxides and hydroxides of colloidal origin, which are the main means of transport and thus the principal link between chemical, physical and granulometric elements in the Adriatic.

Effects of healthy aging and early stage dementia of the Alzheimer's type on components of response time distributions in three attention tasks.

PubMed

Tse, Chi-Shing; Balota, David A; Yap, Melvin J; Duchek, Janet M; McCabe, David P

2010-05-01

The characteristics of response time (RT) distributions beyond measures of central tendency were explored in 3 attention tasks across groups of young adults, healthy older adults, and individuals with very mild dementia of the Alzheimer's type (DAT). Participants were administered computerized Stroop, Simon, and switching tasks, along with psychometric tasks that tap various cognitive abilities and a standard personality inventory (NEO-FFI). Ex-Gaussian (and Vincentile) analyses were used to capture the characteristics of the RT distributions for each participant across the 3 tasks, which afforded 3 components: mu and sigma (mean and standard deviation of the modal portion of the distribution) and tau (the positive tail of the distribution). The results indicated that across all 3 attention tasks, healthy aging produced large changes in the central tendency mu parameter of the distribution along with some change in sigma and tau (mean etap(2) = .17, .08, and .04, respectively). In contrast, early stage DAT primarily produced an increase in the tau component (mean etap(2) = .06). tau was also correlated with the psychometric measures of episodic/semantic memory, working memory, and processing speed, and with the personality traits of neuroticism and conscientiousness. Structural equation modeling indicated a unique relation between a latent tau construct (-.90), as opposed to sigma (-.09) and mu constructs (.24), with working memory measures. The results suggest a critical role of attentional control systems in discriminating healthy aging from early stage DAT and the utility of RT distribution analyses to better specify the nature of such change.

The Comparison between Torsional and Conventional Mode Phacoemulsification in Moderate and Hard Cataracts

PubMed Central

Kim, Dong-Hyun; Wee, Won-Ryang; Lee, Jin-Hak

2010-01-01

Purpose To compare the intraoperative performances and postoperative outcomes of cataract surgery performed with longitudinal phacoemulsification and torsional phacoemulsification in moderate and hard cataracts. Methods Of 85 patients who had senile cataracts, 102 eyes were operated on using the Infiniti Vision System. Preoperative examinations (slit lamp examination, mean central corneal thickness, and central endothelial cell counts) were performed for each patient. Cataracts were subdivided into moderate and hard, according to the Lens Opacities Classification System III grading of nucleus opalescence (NO). Eyes in each cataract group were randomly assigned to conventional and torsional phaco-mode. Intraoperative parameters, including ultrasound time (UST), cumulative dissipated energy (CDE), and the balanced salt solution plus (BSSP) volume utilized were evaluated. Best corrected visual acuity (BCVA) was checked on postoperative day 30; mean central corneal thickness and central endothelial cell counts were investigated on postoperative days 7 and 30. Results Preoperative BCVA and mean grading of NO showed no difference in both groups. Preoperative endothelial cell count and central corneal thickness also showed no significant difference in both groups. In the moderate cataract group, the CDE, UST, and BSSP volume were significantly lower in the torsional mode than the longitudinal mode, but they did not show any difference in the hard cataract group. Torsional group showed less endothelial cell loss and central corneal thickening at postoperative day seven in moderate cataracts but showed no significant differences, as compared with the longitudinal group, by postoperative day 30. Conclusions Torsional phacoemulsification showed superior efficiency for moderate cataracts, as compared with longitudinal phacoemulsification, in the early postoperative stage. PMID:21165231

The comparison between torsional and conventional mode phacoemulsification in moderate and hard cataracts.

PubMed

Kim, Dong-Hyun; Wee, Won-Ryang; Lee, Jin-Hak; Kim, Mee-Kum

2010-12-01

To compare the intraoperative performances and postoperative outcomes of cataract surgery performed with longitudinal phacoemulsification and torsional phacoemulsification in moderate and hard cataracts. Of 85 patients who had senile cataracts, 102 eyes were operated on using the Infiniti Vision System. Preoperative examinations (slit lamp examination, mean central corneal thickness, and central endothelial cell counts) were performed for each patient. Cataracts were subdivided into moderate and hard, according to the Lens Opacities Classification System III grading of nucleus opalescence (NO). Eyes in each cataract group were randomly assigned to conventional and torsional phaco-mode. Intraoperative parameters, including ultrasound time (UST), cumulative dissipated energy (CDE), and the balanced salt solution plus (BSSP) volume utilized were evaluated. Best corrected visual acuity (BCVA) was checked on postoperative day 30; mean central corneal thickness and central endothelial cell counts were investigated on postoperative days 7 and 30. Preoperative BCVA and mean grading of NO showed no difference in both groups. Preoperative endothelial cell count and central corneal thickness also showed no significant difference in both groups. In the moderate cataract group, the CDE, UST, and BSSP volume were significantly lower in the torsional mode than the longitudinal mode, but they did not show any difference in the hard cataract group. Torsional group showed less endothelial cell loss and central corneal thickening at postoperative day seven in moderate cataracts but showed no significant differences, as compared with the longitudinal group, by postoperative day 30. Torsional phacoemulsification showed superior efficiency for moderate cataracts, as compared with longitudinal phacoemulsification, in the early postoperative stage.

Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study

PubMed Central

Westera, Liset; van Viegen, Tanja; Jeyarajah, Jenny; Azad, Azar; Bilsborough, Janine; van den Brink, Gijs R; Cremer, Jonathan; Danese, Silvio; D'Haens, Geert; Eckmann, Lars; Faubion, William; Filice, Melissa; Korf, Hannelie; McGovern, Dermot; Panes, Julian; Salas, Azucena; Sandborn, William J; Silverberg, Mark S; Smith, Michelle I; Vermeire, Severine; Vetrano, Stefania; Shackelton, Lisa M; Stitt, Larry; Jairath, Vipul; Levesque, Barrett G; Spencer, David M; Feagan, Brian G; Vande Casteele, Niels

2017-01-01

Objectives: Flow cytometry (FC) aids in characterization of cellular and molecular factors involved in pathologic immune responses. Although FC has potential to facilitate early drug development in inflammatory bowel disease, interlaboratory variability limits its use in multicenter trials. Standardization of methods may address this limitation. We compared variability in FC-aided quantitation of T-cell responses across international laboratories using three analytical strategies. Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from three healthy donors, stimulated with phorbol 12-myristate 13-acetate and ionomycin at a central laboratory, fixed, frozen, and shipped to seven international laboratories. Permeabilization and staining was performed in triplicate at each laboratory using a common protocol and centrally provided reagents. Gating was performed using local gating with a local strategy (LGLS), local gating with a central strategy (LGCS), and central gating (CG). Median cell percentages were calculated across triplicates and donors, and reported for each condition and strategy. The coefficient of variation (CV) was calculated across laboratories. Between-strategy comparisons were made using a two-way analysis of variance adjusting for donor. Results: Mean interlaboratory CV ranged from 1.8 to 102.1% depending on cell population and gating strategy (LGLS, 4.4–102.1% LGCS, 10.9–65.6% CG, 1.8–20.9%). Mean interlaboratory CV differed significantly across strategies and was consistently lower with CG. Conclusions: Central gating was the only strategy with mean CVs consistently lower than 25%, which is a proposed standard for pharmacodynamic and exploratory biomarker assays. PMID:29095427

Investigation of optical current transformer signal processing method based on an improved Kalman algorithm

NASA Astrophysics Data System (ADS)

Shen, Yan; Ge, Jin-ming; Zhang, Guo-qing; Yu, Wen-bin; Liu, Rui-tong; Fan, Wei; Yang, Ying-xuan

2018-01-01

This paper explores the problem of signal processing in optical current transformers (OCTs). Based on the noise characteristics of OCTs, such as overlapping signals, noise frequency bands, low signal-to-noise ratios, and difficulties in acquiring statistical features of noise power, an improved standard Kalman filtering algorithm was proposed for direct current (DC) signal processing. The state-space model of the OCT DC measurement system is first established, and then mixed noise can be processed by adding mixed noise into measurement and state parameters. According to the minimum mean squared error criterion, state predictions and update equations of the improved Kalman algorithm could be deduced based on the established model. An improved central difference Kalman filter was proposed for alternating current (AC) signal processing, which improved the sampling strategy and noise processing of colored noise. Real-time estimation and correction of noise were achieved by designing AC and DC noise recursive filters. Experimental results show that the improved signal processing algorithms had a good filtering effect on the AC and DC signals with mixed noise of OCT. Furthermore, the proposed algorithm was able to achieve real-time correction of noise during the OCT filtering process.

Effects of Methylphenidate (Ritalin) on Auditory Performance in Children with Attention and Auditory Processing Disorders.

ERIC Educational Resources Information Center

Tillery, Kim L.; Katz, Jack; Keller, Warren D.

2000-01-01

A double-blind, placebo-controlled study examined effects of methylphenidate (Ritalin) on auditory processing in 32 children with both attention deficit hyperactivity disorder and central auditory processing (CAP) disorder. Analyses revealed that Ritalin did not have a significant effect on any of the central auditory processing measures, although…

Central macular thickness in patients with type 2 diabetes mellitus without clinical retinopathy.

PubMed

Demir, Mehmet; Oba, Ersin; Dirim, Burcu; Ozdal, Erhan; Can, Efe

2013-04-09

An increase in macular thickness due to fluid accumulation in the macula in patients with diabetes mellitus. Optical coherence tomography (OCT) has been shown to be highly reproducible in measuring macular thickness in normal individuals and diabetic patients. OCT can detect subtle changes of macular thickness. The aim of this study is to compare central macular thickness (CMT) of diabetic patients with type 2 diabetes without clinical retinopathy and normal controls, in order to assess possible increased macular thickness associated with diabetes mellitus. Optical coherence tomography (OCT) measurements were performed in 124 eyes of 62 subjects with diabetes mellitus without clinically retinopathy (study group: 39 female, 23 male, mean age: 55.06 ± 9.77 years) and in 120 eyes of 60 healthy subjects (control group: 35 female, 25 male, mean age: 55.78 ± 10.34 years). Blood biochemistry parameters were analyzed in all cases. The data for central macular thickness (at 1 mm) and the levels of the fasting plasma glucose and glycosylated hemoglobin (HbA1c) were compared in both groups. The mean central macular thickness was 232.12 ±24.41 μm in the study group and 227.19 ± 29.94 μm in the control group.The mean HbA1c level was 8.92 ± 2.58% in the study group and 5.07 ± 0.70% in the control group (p=0.001). No statistically significant relationship was found between CMT, HbA1c, and fasting plasma glucose level in either group (p=0.05). Central macular thickness was not significantly thicker in patients with type 2 diabetes without clinical retinopathy than in healthy subjects.

Stepwise introduction of the 'Best Care Always' central-line-associated bloodstream infection prevention bundle in a network of South African hospitals.

PubMed

Richards, G A; Brink, A J; Messina, A P; Feldman, C; Swart, K; van den Bergh, D

2017-09-01

Healthcare-associated infection (HCAI) remains a major international problem. The 'Best Care Always!' (BCA) campaign was launched in South Africa to reduce preventable HCAI, including central-line-associated bloodstream infection (CLABSI). The intervention took place in 43 Netcare Private Hospitals, increasing later to 49 with 958 intensive care units (ICUs) and 439 high-care (HC) beds and 1207 ICUs and 493 HC beds, respectively. Phase 1, April 2010 to March 2011, ICU infection prevention and control (IPC) nurse-driven change: commitment from management and doctors and training of IPC nurses. Bundle compliance and infections per 1000 central-line-days were incorporated as standard IPC measures and captured monthly. Phase 2, April 2011 to March 2012, breakthrough collaborative method: multiple regional learning sessions for nursing leaders, IPC nurses and unit managers. Phase 3, April 2012 to May 2016: sustained goal-setting, benchmarks, ongoing audits. A total of 1,119,558 central-line-days were recorded. Bundle compliance improved significantly from a mean of 73.1% [standard deviation (SD): 11.2; range: 40.6-81.7%] in Phase 1 to a mean of 90.5% (SD: 4.7; range: 76.5-97.2%) in Phase 3 (P = 0.0004). The CLABSI rate declined significantly from a mean of 3.55 (SD: 0.82; range: 2.54-5.78) per 1000 central-line-days in Phase 1 to a mean of 0.13 (SD: 0.09; range: 0-0.33) (P < 0.0001). This intervention, the first of its kind in South Africa, through considerable motivation and education, and through competition between hospitals resulted in significant decreases in CLABSI. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Galaxy properties in clusters. II. Backsplash galaxies

NASA Astrophysics Data System (ADS)

Muriel, H.; Coenda, V.

2014-04-01

Aims: We explore the properties of galaxies on the outskirts of clusters and their dependence on recent dynamical history in order to understand the real impact that the cluster core has on the evolution of galaxies. Methods: We analyse the properties of more than 1000 galaxies brighter than M0.1r = - 19.6 on the outskirts of 90 clusters (1 < r/rvir < 2) in the redshift range 0.05 < z < 0.10. Using the line of sight velocity of galaxies relative to the cluster's mean, we selected low and high velocity subsamples. Theoretical predictions indicate that a significant fraction of the first subsample should be backsplash galaxies, that is, objects that have already orbited near the cluster centre. A significant proportion of the sample of high relative velocity (HV) galaxies seems to be composed of infalling objects. Results: Our results suggest that, at fixed stellar mass, late-type galaxies in the low-velocity (LV) sample are systematically older, redder, and have formed fewer stars during the last 3 Gyrs than galaxies in the HV sample. This result is consistent with models that assume that the central regions of clusters are effective in quenching the star formation by means of processes such as ram pressure stripping or strangulation. At fixed stellar mass, LV galaxies show some evidence of having higher surface brightness and smaller size than HV galaxies. These results are consistent with the scenario where galaxies that have orbited the central regions of clusters are more likely to suffer tidal effects, producing loss of mass as well as a re-distribution of matter towards more compact configurations. Finally, we found a higher fraction of ET galaxies in the LV sample, supporting the idea that the central region of clusters of galaxies may contribute to the transformation of morphological types towards earlier types.

Detection device

DOEpatents

Smith, Jay E.

1984-01-01

The present invention is directed to a detection device comprising: (1) an entrance chamber, (2) a central chamber, and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

Detection device

DOEpatents

Smith, J.E.

1981-02-27

The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

Social value and individual choice: The value of a choice-based decision-making process in a collectively funded health system.

PubMed

Espinoza, Manuel Antonio; Manca, Andrea; Claxton, Karl; Sculpher, Mark

2018-02-01

Evidence about cost-effectiveness is increasingly being used to inform decisions about the funding of new technologies that are usually implemented as guidelines from centralized decision-making bodies. However, there is also an increasing recognition for the role of patients in determining their preferred treatment option. This paper presents a method to estimate the value of implementing a choice-based decision process using the cost-effectiveness analysis toolbox. This value is estimated for 3 alternative scenarios. First, it compares centralized decisions, based on population average cost-effectiveness, against a decision process based on patient choice. Second, it compares centralized decision based on patients' subgroups versus an individual choice-based decision process. Third, it compares a centralized process based on average cost-effectiveness against a choice-based process where patients choose according to a different measure of outcome to that used by the centralized decision maker. The methods are applied to a case study for the management of acute coronary syndrome. It is concluded that implementing a choice-based process of treatment allocation may be an option in collectively funded health systems. However, its value will depend on the specific health problem and the social values considered relevant to the health system. Copyright © 2017 John Wiley & Sons, Ltd.

Amplitude and dynamics of polarization-plane signaling in the central complex of the locust brain

PubMed Central

Bockhorst, Tobias

2015-01-01

The polarization pattern of skylight provides a compass cue that various insect species use for allocentric orientation. In the desert locust, Schistocerca gregaria, a network of neurons tuned to the electric field vector (E-vector) angle of polarized light is present in the central complex of the brain. Preferred E-vector angles vary along slices of neuropils in a compasslike fashion (polarotopy). We studied how the activity in this polarotopic population is modulated in ways suited to control compass-guided locomotion. To this end, we analyzed tuning profiles using measures of correlation between spike rate and E-vector angle and, furthermore, tested for adaptation to stationary angles. The results suggest that the polarotopy is stabilized by antagonistic integration across neurons with opponent tuning. Downstream to the input stage of the network, responses to stationary E-vector angles adapted quickly, which may correlate with a tendency to steer a steady course previously observed in tethered flying locusts. By contrast, rotating E-vectors corresponding to changes in heading direction under a natural sky elicited nonadapting responses. However, response amplitudes were particularly variable at the output stage, covarying with the level of ongoing activity. Moreover, the responses to rotating E-vector angles depended on the direction of rotation in an anticipatory manner. Our observations support a view of the central complex as a substrate of higher-stage processing that could assign contextual meaning to sensory input for motor control in goal-driven behaviors. Parallels to higher-stage processing of sensory information in vertebrates are discussed. PMID:25609107

Application of failure mode and effect analysis in managing catheter-related blood stream infection in intensive care unit

PubMed Central

Li, Xixi; He, Mei; Wang, Haiyan

2017-01-01

Abstract In this study, failure mode and effect analysis (FMEA), a proactive tool, was applied to reduce errors associated with the process which begins with assessment of patient and ends with treatment of complications. The aim of this study is to assess whether FMEA implementation will significantly reduce the incidence of catheter-related bloodstream infections (CRBSIs) in intensive care unit. The FMEA team was constructed. A team of 15 medical staff from different departments were recruited and trained. Their main responsibility was to analyze and score all possible processes of central venous catheterization failures. Failure modes with risk priority number (RPN) ≥100 (top 10 RPN scores) were deemed as high-priority-risks, meaning that they needed immediate corrective action. After modifications were put, the resulting RPN was compared with the previous one. A centralized nursing care system was designed. A total of 25 failure modes were identified. High-priority risks were “Unqualified medical device sterilization” (RPN, 337), “leukopenia, very low immunity” (RPN, 222), and “Poor hand hygiene Basic diseases” (RPN, 160). The corrective measures that we took allowed a decrease in the RPNs, especially for the high-priority risks. The maximum reduction was approximately 80%, as observed for the failure mode “Not creating the maximal barrier for patient.” The averaged incidence of CRBSIs was reduced from 5.19% to 1.45%, with 3 months of 0 infection rate. The FMEA can effectively reduce incidence of CRBSIs, improve the security of central venous catheterization technology, decrease overall medical expenses, and improve nursing quality. PMID:29390515

Environmental Behavior of Chlorpyrifos and Endosulfan in a Tropical Soil in Central Brazil.

PubMed

Dores, Eliana F G C; Spadotto, Claudio A; Weber, Oscarlina L S; Dalla Villa, Ricardo; Vecchiato, Antonio B; Pinto, Alicio A

2016-05-25

The environmental behavior of chlorpyrifos and endosulfan in soil was studied in the central-western region of Brazil by means of a field experiment. Sorption was evaluated in laboratory batch experiments. Chlorpyrifos and endosulfan were applied to experimental plots on uncultivated soil and the following processes were studied: leaching, runoff, and dissipation in top soil. Field dissipation of chlorpyrifos and endosulfan was more rapid than reported in temperate climates. Despite the high Koc of the studied pesticides, the two endosulfan isomers and endosulfan sulfate as well as chlorpyrifos were detected in percolated water. In runoff water and sediment, both endosulfan isomers and endosulfan sulfate were detected throughout the period of study. Observed losses of endosulfan by leaching (below a depth of 50 cm) and runoff were 0.0013 and 1.04% of the applied amount, whereas chlorpyrifos losses were 0.003 and 0.032%, respectively. Leaching of these highly adsorbed pesticides was attributed to preferential flow.

Spectra of double-cumulative photons in the central rapidity region at high transverse momenta

NASA Astrophysics Data System (ADS)

Alekseev, I. G.; Golubev, A. A.; Goryachev, V. S.; Dzubenko, G. B.; Dolgolenko, A. G.; Zhigareva, N. M.; Kiselev, S. M.; Mikhaylov, K. R.; Morozova, E. A.; Polozov, P. A.; Prokudin, M. S.; Romanov, D. V.; Svirida, D. N.; Stavinsky, A. V.; Stolin, V. L.; Sharkov, G. B.

2015-11-01

The spectra of photons produced in the interaction between carbon ions of kinetic energy 2.0 and 3.2 GeV per nucleon and beryllium nuclei were measured at the FLINT facility by means of electromagnetic calorimeters that is deployed at the accelerator of the Institute for Theoretical and Experimental Physics (ITEP, Moscow). The spectra in question were measured in the central rapidity region (at angles between 35° and 73° in the laboratory frame) at photon energies of 1 to 3 GeV by using a cumulative-photon trigger. An analysis of the data obtained in this way reveals that the interaction of multinucleon fluctuation in the projectile nucleus with a multinucleon fluctuation in the target nucleus is a dominant process that leads to photon production in the measured region of angles and momenta. As a development of the generally accepted terminology, an interaction of this type may be called a double cumulative interaction.

Grey-Markov prediction model based on background value optimization and central-point triangular whitenization weight function

NASA Astrophysics Data System (ADS)

Ye, Jing; Dang, Yaoguo; Li, Bingjun

2018-01-01

Grey-Markov forecasting model is a combination of grey prediction model and Markov chain which show obvious optimization effects for data sequences with characteristics of non-stationary and volatility. However, the state division process in traditional Grey-Markov forecasting model is mostly based on subjective real numbers that immediately affects the accuracy of forecasting values. To seek the solution, this paper introduces the central-point triangular whitenization weight function in state division to calculate possibilities of research values in each state which reflect preference degrees in different states in an objective way. On the other hand, background value optimization is applied in the traditional grey model to generate better fitting data. By this means, the improved Grey-Markov forecasting model is built. Finally, taking the grain production in Henan Province as an example, it verifies this model's validity by comparing with GM(1,1) based on background value optimization and the traditional Grey-Markov forecasting model.

Geologic studies in Alaska by the U.S. Geological Survey, 1997

USGS Publications Warehouse

Kelley, Karen D.

1999-01-01

Geologic Framework studies provide background information that is the scientific basis for present and future studies of the environment, mineral and energy resources, paleoclimate, and hazards in Alaska. One paper presents the results of sedimentologic and paleontologic comparisons of lower Paleozoic, deep-water-facies rock units in central Alaska (Dumoulin and others). The authors show which of these units are likely to correlate with one another, suggest likely source regions, and provide a structural restoration of units that have been fragmented by large fault motions. A second framework paper provides a map, rock descriptions, and chemical compositions of volcanic rocks in a newly recognized, geologically young volcanic center in the Aleutian volcanic arc (Hildreth and others). A third paper presents an interesting summary of gravity changes that occurred in south-central Alaska during the great earthquake of 1964 and for the following 25 years (Barnes). Gravity changes correlate with land-elevation changes in some cases, but not in others, which means that different processes are responsible for the gravity changes.

Generalizing a nonlinear geophysical flood theory to medium-sized river networks

USGS Publications Warehouse

Gupta, Vijay K.; Mantilla, Ricardo; Troutman, Brent M.; Dawdy, David; Krajewski, Witold F.

2010-01-01

The central hypothesis of a nonlinear geophysical flood theory postulates that, given space-time rainfall intensity for a rainfall-runoff event, solutions of coupled mass and momentum conservation differential equations governing runoff generation and transport in a self-similar river network produce spatial scaling, or a power law, relation between peak discharge and drainage area in the limit of large area. The excellent fit of a power law for the destructive flood event of June 2008 in the 32,400-km2 Iowa River basin over four orders of magnitude variation in drainage areas supports the central hypothesis. The challenge of predicting observed scaling exponent and intercept from physical processes is explained. We show scaling in mean annual peak discharges, and briefly discuss that it is physically connected with scaling in multiple rainfall-runoff events. Scaling in peak discharges would hold in a non-stationary climate due to global warming but its slope and intercept would change.

The tuberculosis program of Catalonia's Central Health Region (1986-1993).

PubMed

Miret-Cuadras, P; Gonzalez-Fernandez, P; Lopez-Sanmartin, J L; Martin-Ramos, A; Pina Gutierrez, J M

1997-04-01

Catalonia's Central Health Region antituberculosis program, which began in 1985. To evaluate the cooperation of health staff and the program's effectiveness after 8 years. The following data from the nominal notifications and the expanded case reports were processed: epidemiological, clinical and treatment data, each patient's end results and the outcome of the contact investigation. The implementation of the program was evaluated by means of the number of notifications and contact investigations received, and its effectiveness was assessed by the percentage of sputum smear positive cases having completed treatment. There was an increase in the number of patients with an expanded case report (from 74% to 100%), with a final notification (from 61% to 99%) and with contact investigation (from 29% to 79%). The sputum smear positive cases who completed the treatment after 1990 exceeded 85%. The implementation of the program in the Region's health system is good and is improving in parallel with the control of the disease.

Investigation of Central Pain Processing in Post-Operative Shoulder Pain and Disability

PubMed Central

Valencia, Carolina; Fillingim, Roger B.; Bishop, Mark; Wu, Samuel S.; Wright, Thomas W.; Moser, Michael; Farmer, Kevin; George, Steven Z.

2014-01-01

Measures of central pain processing like conditioned pain modulation (CPM), and suprathreshold heat pain response (SHPR) have been described to assess different components of central pain modulatory mechanisms. Central pain processing potentially play a role in the development of postsurgical pain, however, the role of CPM and SHPR in explaining postoperative clinical pain and disability is still unclear. Seventy eight patients with clinical shoulder pain were included in this study. Patients were examined before shoulder surgery, at 3 months, and 6 months after surgery. The primary outcome measures were pain intensity and upper extremity disability. Analyses revealed that the change score (baseline – 3 months) of 5th pain rating of SHPR accounted for a significant amount of variance in 6 month postsurgical clinical pain intensity and disability after age, sex, preoperative pain intensity, and relevant psychological factors were considered. The present study suggests that baseline measures of central pain processing were not predictive of 6 month postoperative pain outcome. Instead, the 3 month change in SHPR might be a relevant factor in the transition to elevated 6-month postoperative pain and disability outcomes. In patients with shoulder pain, the 3 month change in a measure of central pain processing might be a relevant factor in the transition to elevated 6-month postoperative pain and disability scores. PMID:24042347

Contrasting effects of feature-based statistics on the categorisation and basic-level identification of visual objects.

PubMed

Taylor, Kirsten I; Devereux, Barry J; Acres, Kadia; Randall, Billi; Tyler, Lorraine K

2012-03-01

Conceptual representations are at the heart of our mental lives, involved in every aspect of cognitive functioning. Despite their centrality, a long-standing debate persists as to how the meanings of concepts are represented and processed. Many accounts agree that the meanings of concrete concepts are represented by their individual features, but disagree about the importance of different feature-based variables: some views stress the importance of the information carried by distinctive features in conceptual processing, others the features which are shared over many concepts, and still others the extent to which features co-occur. We suggest that previously disparate theoretical positions and experimental findings can be unified by an account which claims that task demands determine how concepts are processed in addition to the effects of feature distinctiveness and co-occurrence. We tested these predictions in a basic-level naming task which relies on distinctive feature information (Experiment 1) and a domain decision task which relies on shared feature information (Experiment 2). Both used large-scale regression designs with the same visual objects, and mixed-effects models incorporating participant, session, stimulus-related and feature statistic variables to model the performance. We found that concepts with relatively more distinctive and more highly correlated distinctive relative to shared features facilitated basic-level naming latencies, while concepts with relatively more shared and more highly correlated shared relative to distinctive features speeded domain decisions. These findings demonstrate that the feature statistics of distinctiveness (shared vs. distinctive) and correlational strength, as well as the task demands, determine how concept meaning is processed in the conceptual system. Copyright © 2011 Elsevier B.V. All rights reserved.

[Multidimensional Strategy Regarding the Reduction of Central-Line Associated Infection in Pediatric Intensive Care].

PubMed

Rodrigues, Jorge; Dias, Andrea; Oliveira, Guiomar; Farela Neves, José

2016-06-01

To determine the central-line associated bloodstream infection rate after implementation of central venous catheter-care practice bundles and guidelines and to compare it with the previous central-line associated bloodstream infection rate. A prospective, longitudinal, observational descriptive study with an exploratory component was performed in a Pediatric Intensive Care Unit during five months. The universe was composed of every child admitted to Pediatric Intensive Care Unit who inserted a central venous catheter. A comparative study with historical controls was performed to evaluate the result of the intervention (group 1 versus group 2). Seventy five children were included, with a median age of 23 months: 22 (29.3%) newborns; 28 (37.3%) with recent surgery and 32 (43.8%) with underlying illness. A total of 105 central venous catheter were inserted, the majority a single central venous catheter (69.3%), with a mean duration of 6.8 ± 6.7 days. The most common type of central venous catheter was the short-term, non-tunneled central venous catheter (45.7%), while the subclavian and brachial flexure veins were the most frequent insertion sites (both 25.7%). There were no cases of central-line associated bloodstream infection reported during this study. Comparing with historical controls (group 1), both groups were similar regarding age, gender, department of origin and place of central venous catheter insertion. In the current study (group 2), the median length of stay was higher, while the mean duration of central venous catheter (excluding peripherally inserted central line) was similar in both groups. There were no statistical differences regarding central venous catheter caliber and number of lumens. Fewer children admitted to Pediatric Intensive Care Unit had central venous catheter inserted in group 2, with no significant difference between single or multiple central venous catheter. After multidimensional strategy implementation there was no reported central-line associated bloodstream infection Conclusions: Efforts must be made to preserve the same degree of multidimensional prevention, in order to confirm the effective reduction of the central-line associated bloodstream infection rate and to allow its maintenance.

The Central Coherence Account of Autism Revisited: Evidence from the ComFor Study

ERIC Educational Resources Information Center

Noens, Ilse L. J.; van Berckelaer-Onnes, Ina A.

2008-01-01

According to the central coherence account, people with autism have a tendency to focus on local rather than global processing. However, there is considerable controversy about the locus of the weak drive for central coherence. Some studies support enhanced bottom-up processing, whereas others claim reduced top-down feedback. The results of the…

Religion and moral meaning in bioethics.

PubMed

Campbell, Courtney S

1990-01-01

Courtney S. Campbell observes that the practical dilemmas of bioethics often presuppose common questions of meaning about human nature, suffering, dying, and human destiny that are central to religious traditions.

Axonal Elongation into Peripheral Nervous System ``Bridges'' after Central Nervous System Injury in Adult Rats

NASA Astrophysics Data System (ADS)

David, Samuel; Aguayo, Albert J.

1981-11-01

The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as ``bridges'' between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.

Effect of delayed auditory feedback on stuttering with and without central auditory processing disorders.

PubMed

Picoloto, Luana Altran; Cardoso, Ana Cláudia Vieira; Cerqueira, Amanda Venuti; Oliveira, Cristiane Moço Canhetti de

2017-12-07

To verify the effect of delayed auditory feedback on speech fluency of individuals who stutter with and without central auditory processing disorders. The participants were twenty individuals with stuttering from 7 to 17 years old and were divided into two groups: Stuttering Group with Auditory Processing Disorders (SGAPD): 10 individuals with central auditory processing disorders, and Stuttering Group (SG): 10 individuals without central auditory processing disorders. Procedures were: fluency assessment with non-altered auditory feedback (NAF) and delayed auditory feedback (DAF), assessment of the stuttering severity and central auditory processing (CAP). Phono Tools software was used to cause a delay of 100 milliseconds in the auditory feedback. The "Wilcoxon Signal Post" test was used in the intragroup analysis and "Mann-Whitney" test in the intergroup analysis. The DAF caused a statistically significant reduction in SG: in the frequency score of stuttering-like disfluencies in the analysis of the Stuttering Severity Instrument, in the amount of blocks and repetitions of monosyllabic words, and in the frequency of stuttering-like disfluencies of duration. Delayed auditory feedback did not cause statistically significant effects on SGAPD fluency, individuals with stuttering with auditory processing disorders. The effect of delayed auditory feedback in speech fluency of individuals who stutter was different in individuals of both groups, because there was an improvement in fluency only in individuals without auditory processing disorder.

Effects of Muslims praying (Salat) on EEG gamma activity.

PubMed

Doufesh, Hazem; Ibrahim, Fatimah; Safari, Mohammad

2016-08-01

This study investigates the difference of mean gamma EEG power between actual and mimic Salat practices in twenty healthy Muslim subjects. In the actual Salat practice, the participants were asked to recite and performing the physical steps in all four stages of Salat; whereas in the mimic Salat practice, they were instructed to perform only the physical steps without recitation. The gamma power during actual Salat was statistically higher than during mimic Salat in the frontal and parietal regions in all stages. In the actual Salat practice, the left hemisphere exhibited significantly higher mean gamma power in all cerebral regions and all stages, except the central-parietal region in the sitting position, and the frontal area in the bowing position. Increased gamma power during Salat, possibly related to an increase in cognitive and attentional processing, supports the concept of Salat as a focus attention meditation. Copyright © 2016 Elsevier Ltd. All rights reserved.

A novel model for the chaotic dynamics of superdiffusion

NASA Astrophysics Data System (ADS)

Cushman, J. H.; Park, M.; O'Malley, D.

2009-04-01

Previously we've shown that by modeling the convective velocity in a turbulent flow field as Brownian, one obtains Richardson super diffusion where the expected distance between pairs of particles scales with time cubed. By proving generalized central limit type theorems it's possible to show that modeling the velocity or the acceleration as α-stable Levy gives rise to more general scaling laws that can easily explain other super diffusive regimes. The problem with this latter approach is that the mean square displacement of a particle is infinite. Here we provide an alternate approach that gives a power law mean square displacement of any desired order. We do so by constructing compressed and stretched extensions to Brownian motion. The finite size Lyapunov exponent, the underlying stochastic differential equation and its corresponding Fokker-Planck equations are derived. The fractal dimension of these processes turns out to be the same as that of classical Brownian motion.

Atmospheric Carbon Dioxide Record from Flask Measurements at Lampedusa Island (May 1992- December 2000)

DOE Data Explorer

Chamard, Paolo [ENEA, GEM-CLIM, Rome, Italy; Ciattaglia, Luigi [ENEA, GEM-CLIM, Rome, Italy; di Sarra, Alcide [ENEA, GEM-CLIM, Rome, Italy; Monteleone, Francesco [ENEA, GEM-CLIM, Rome, Italy

2001-01-01

Lampedusa Station rests on a rocky seashore on the eastern tip of Lampedusa Island, located south of Sicily in the central Mediterranean Sea. Air samples at Lampedusa Station are collected each Friday in two pairs of 2-L glass flasks. Flasks are evacuated and then pressurized to 280-300 kPa with ambient air at the sampling site. Determinations of CO2 are made by using a Siemens Ultramat 5E nondispersive infrared gas analyzer. Water vapor is removed during the sampling process by means of a chemical trap (Magnesium Perchlorate). During the measurement, residual water vapor is removed by means of a cold trap at -70°C. From the inception of the monitoring program at Lampedusa Station, CO2-in-synthetic air calibration gases have been used. Values are relative to the dry air WMO mole fraction scale.

Application of mental illness stigma theory to Chinese societies: synthesis and new directions.

PubMed

Yang, L H

2007-11-01

The rapidly-evolving literature concerning stigma towards psychiatric illnesses among Chinese groups has demonstrated pervasive negative attitudes and discriminatory treatment towards people with mental illness. However, a systematic integration of current stigma theories and empirical findings to examine how stigma processes may occur among Chinese ethnic groups has yet to be undertaken. This paper first introduces several major stigma models, and specifies how these models provide a theoretical basis as to how stigma broadly acts on individuals with schizophrenia through three main mechanisms: direct individual discrimination, internalisation of negative stereotypes, and structural discrimination. In Chinese societies, the particular manifestations of stigma associated with schizophrenia are shaped by cultural meanings embedded within Confucianism, the centrality of "face", and pejorative aetiological beliefs of mental illnesses. These cultural meanings are reflected in severe and culturally-specific expressions of stigma in Chinese societies. Implications and directions to advance stigma research within Chinese cultural settings are provided.

The burrowing activity of scorpions ( Scorpio maurus palmatus) and their potential contribution to the erosion of Hamra soils in Karkur, central Israel

NASA Astrophysics Data System (ADS)

Rutin, J.

1996-03-01

The burrowing activity of the scorpion Scorpio maurus palmatus was studied on a 1200 m 2 slope of a so-called "Hamra" sandy soil in Karkur, Israel. The main results were (1) The scorpions excavate soil material after rain storms, preparing this material for erosion processes by rain splash and rainwash. (2) The burrowing activity stops in the dry summer and during cold days of the winter. This means that Scorpio Maurus Palmatus is preparing soil for erosion from one storm to the next, and not from one season to the next as was previously thought. Further, it was found that the amount of soil material excavated from the burrow is proportional to the size of the scorpion and that most of the mounds were deposited toward the upper part of the slope which means that part is washed back into the burrow itself.

Fluorescence correlation spectroscopy: the case of subdiffusion.

PubMed

Lubelski, Ariel; Klafter, Joseph

2009-03-18

The theory of fluorescence correlation spectroscopy is revisited here for the case of subdiffusing molecules. Subdiffusion is assumed to stem from a continuous-time random walk process with a fat-tailed distribution of waiting times and can therefore be formulated in terms of a fractional diffusion equation (FDE). The FDE plays the central role in developing the fluorescence correlation spectroscopy expressions, analogous to the role played by the simple diffusion equation for regular systems. Due to the nonstationary nature of the continuous-time random walk/FDE, some interesting properties emerge that are amenable to experimental verification and may help in discriminating among subdiffusion mechanisms. In particular, the current approach predicts 1), a strong dependence of correlation functions on the initial time (aging); 2), sensitivity of correlation functions to the averaging procedure, ensemble versus time averaging (ergodicity breaking); and 3), that the basic mean-squared displacement observable depends on how the mean is taken.

Influence of solar variability on the occurrence of central European weather types from 1763 to 2009

NASA Astrophysics Data System (ADS)

Schwander, Mikhaël; Rohrer, Marco; Brönnimann, Stefan; Malik, Abdul

2017-09-01

The impact of solar variability on weather and climate in central Europe is still not well understood. In this paper we use a new time series of daily weather types to analyse the influence of the 11-year solar cycle on the tropospheric weather of central Europe. We employ a novel, daily weather type classification over the period 1763-2009 and investigate the occurrence frequency of weather types under low, moderate, and high solar activity level. Results show a tendency towards fewer days with westerly and west-southwesterly flow over central Europe under low solar activity. In parallel, the occurrence of northerly and easterly types increases. For the 1958-2009 period, a more detailed view can be gained from reanalysis data. Mean sea level pressure composites under low solar activity also show a reduced zonal flow, with an increase of the mean blocking frequency between Iceland and Scandinavia. Weather types and reanalysis data show that the 11-year solar cycle influences the late winter atmospheric circulation over central Europe with colder (warmer) conditions under low (high) solar activity.

Shorebird Migration Patterns in Response to Climate Change: A Modeling Approach

NASA Technical Reports Server (NTRS)

Smith, James A.

2010-01-01

The availability of satellite remote sensing observations at multiple spatial and temporal scales, coupled with advances in climate modeling and information technologies offer new opportunities for the application of mechanistic models to predict how continental scale bird migration patterns may change in response to environmental change. In earlier studies, we explored the phenotypic plasticity of a migratory population of Pectoral sandpipers by simulating the movement patterns of an ensemble of 10,000 individual birds in response to changes in stopover locations as an indicator of the impacts of wetland loss and inter-annual variability on the fitness of migratory shorebirds. We used an individual based, biophysical migration model, driven by remotely sensed land surface data, climate data, and biological field data. Mean stop-over durations and stop-over frequency with latitude predicted from our model for nominal cases were consistent with results reported in the literature and available field data. In this study, we take advantage of new computing capabilities enabled by recent GP-GPU computing paradigms and commodity hardware (general purchase computing on graphics processing units). Several aspects of our individual based (agent modeling) approach lend themselves well to GP-GPU computing. We have been able to allocate compute-intensive tasks to the graphics processing units, and now simulate ensembles of 400,000 birds at varying spatial resolutions along the central North American flyway. We are incorporating additional, species specific, mechanistic processes to better reflect the processes underlying bird phenotypic plasticity responses to different climate change scenarios in the central U.S.

The Dynamic Range Paradox: A Central Auditory Model of Intensity Change Detection

PubMed Central

Simpson, Andrew J.R.; Reiss, Joshua D.

2013-01-01

In this paper we use empirical loudness modeling to explore a perceptual sub-category of the dynamic range problem of auditory neuroscience. Humans are able to reliably report perceived intensity (loudness), and discriminate fine intensity differences, over a very large dynamic range. It is usually assumed that loudness and intensity change detection operate upon the same neural signal, and that intensity change detection may be predicted from loudness data and vice versa. However, while loudness grows as intensity is increased, improvement in intensity discrimination performance does not follow the same trend and so dynamic range estimations of the underlying neural signal from loudness data contradict estimations based on intensity just-noticeable difference (JND) data. In order to account for this apparent paradox we draw on recent advances in auditory neuroscience. We test the hypothesis that a central model, featuring central adaptation to the mean loudness level and operating on the detection of maximum central-loudness rate of change, can account for the paradoxical data. We use numerical optimization to find adaptation parameters that fit data for continuous-pedestal intensity change detection over a wide dynamic range. The optimized model is tested on a selection of equivalent pseudo-continuous intensity change detection data. We also report a supplementary experiment which confirms the modeling assumption that the detection process may be modeled as rate-of-change. Data are obtained from a listening test (N = 10) using linearly ramped increment-decrement envelopes applied to pseudo-continuous noise with an overall level of 33 dB SPL. Increments with half-ramp durations between 5 and 50,000 ms are used. The intensity JND is shown to increase towards long duration ramps (p<10−6). From the modeling, the following central adaptation parameters are derived; central dynamic range of 0.215 sones, 95% central normalization, and a central loudness JND constant of 5.5×10−5 sones per ms. Through our findings, we argue that loudness reflects peripheral neural coding, and the intensity JND reflects central neural coding. PMID:23536749

Successful conservative treatment outcomes and clinical characteristics of congenital hypoplasia of the extensor tendon central slip.

PubMed

Hidaka, N; Uemura, T; Nakamura, H

2017-03-01

Congenital hypoplasia of the extensor tendon central slip is a rare entity. This article describes the clinical characteristics in a series of 22 fingers in 16 patients (mean age: 10 months), and the outcomes of conservative treatment. Nine of 22 fingers were classified as slender or hypoplastic. Treatment with bracing was successful in 21 digits, resulting in full active extension of the proximal interphalangeal joint at a mean of 8.5 months after treatment. Bracing was unsuccessful in one digit, in which operative treatment resulted in a successful outcome. Some residual deformity was observed in ten fingers after a mean follow-up period of 2 years and 1 month. Congenital hypoplasia of the central slip can be treated successfully by the conservative hand bracing when worn with full compliance. Treatment time is extended by the infrequent application of the hand brace or in the case of hypoplastic slender fingers. IV.

Impact of parameterization of physical processes on simulation of track and intensity of tropical cyclone Nargis (2008) with WRF-NMM model.

PubMed

Pattanayak, Sujata; Mohanty, U C; Osuri, Krishna K

2012-01-01

The present study is carried out to investigate the performance of different cumulus convection, planetary boundary layer, land surface processes, and microphysics parameterization schemes in the simulation of a very severe cyclonic storm (VSCS) Nargis (2008), developed in the central Bay of Bengal on 27 April 2008. For this purpose, the nonhydrostatic mesoscale model (NMM) dynamic core of weather research and forecasting (WRF) system is used. Model-simulated track positions and intensity in terms of minimum central mean sea level pressure (MSLP), maximum surface wind (10 m), and precipitation are verified with observations as provided by the India Meteorological Department (IMD) and Tropical Rainfall Measurement Mission (TRMM). The estimated optimum combination is reinvestigated with six different initial conditions of the same case to have better conclusion on the performance of WRF-NMM. A few more diagnostic fields like vertical velocity, vorticity, and heat fluxes are also evaluated. The results indicate that cumulus convection play an important role in the movement of the cyclone, and PBL has a crucial role in the intensification of the storm. The combination of Simplified Arakawa Schubert (SAS) convection, Yonsei University (YSU) PBL, NMM land surface, and Ferrier microphysics parameterization schemes in WRF-NMM give better track and intensity forecast with minimum vector displacement error.

Cell fusion in the brain: two cells forward, one cell back.

PubMed

Kemp, Kevin; Wilkins, Alastair; Scolding, Neil

2014-11-01

Adult stem cell populations, notably those which reside in the bone marrow, have been shown to contribute to several neuronal cell types in the rodent and human brain. The observation that circulating bone marrow cells can migrate into the central nervous system and fuse with, in particular, cerebellar Purkinje cells has suggested, at least in part, a potential mechanism behind this process. Experimentally, the incidence of cell fusion in the brain is enhanced with age, radiation exposure, inflammation, chemotherapeutic drugs and even selective damage to the neurons themselves. The presence of cell fusion, shown by detection of increased bi-nucleated neurons, has also been described in a variety of human central nervous system diseases, including both multiple sclerosis and Alzheimer's disease. Accumulating evidence is therefore raising new questions into the biological significance of cell fusion, with the possibility that it represents an important means of cell-mediated neuroprotection or rescue of highly complex neurons that cannot be replaced in adult life. Here, we discuss the evidence behind this phenomenon in the rodent and human brain, with a focus on the subsequent research investigating the physiological mechanisms of cell fusion underlying this process. We also highlight how these studies offer new insights into endogenous neuronal repair, opening new exciting avenues for potential therapeutic interventions against neurodegeneration and brain injury.

Turning down the noise: the benefit of musical training on the aging auditory brain.

PubMed

Alain, Claude; Zendel, Benjamin Rich; Hutka, Stefanie; Bidelman, Gavin M

2014-02-01

Age-related decline in hearing abilities is a ubiquitous part of aging, and commonly impacts speech understanding, especially when there are competing sound sources. While such age effects are partially due to changes within the cochlea, difficulties typically exist beyond measurable hearing loss, suggesting that central brain processes, as opposed to simple peripheral mechanisms (e.g., hearing sensitivity), play a critical role in governing hearing abilities late into life. Current training regimens aimed to improve central auditory processing abilities have experienced limited success in promoting listening benefits. Interestingly, recent studies suggest that in young adults, musical training positively modifies neural mechanisms, providing robust, long-lasting improvements to hearing abilities as well as to non-auditory tasks that engage cognitive control. These results offer the encouraging possibility that musical training might be used to counteract age-related changes in auditory cognition commonly observed in older adults. Here, we reviewed studies that have examined the effects of age and musical experience on auditory cognition with an emphasis on auditory scene analysis. We infer that musical training may offer potential benefits to complex listening and might be utilized as a means to delay or even attenuate declines in auditory perception and cognition that often emerge later in life. Copyright © 2013 Elsevier B.V. All rights reserved.

Procedures for central auditory processing screening in schoolchildren.

PubMed

Carvalho, Nádia Giulian de; Ubiali, Thalita; Amaral, Maria Isabel Ramos do; Santos, Maria Francisca Colella

2018-03-22

Central auditory processing screening in schoolchildren has led to debates in literature, both regarding the protocol to be used and the importance of actions aimed at prevention and promotion of auditory health. Defining effective screening procedures for central auditory processing is a challenge in Audiology. This study aimed to analyze the scientific research on central auditory processing screening and discuss the effectiveness of the procedures utilized. A search was performed in the SciELO and PUBMed databases by two researchers. The descriptors used in Portuguese and English were: auditory processing, screening, hearing, auditory perception, children, auditory tests and their respective terms in Portuguese. original articles involving schoolchildren, auditory screening of central auditory skills and articles in Portuguese or English. studies with adult and/or neonatal populations, peripheral auditory screening only, and duplicate articles. After applying the described criteria, 11 articles were included. At the international level, central auditory processing screening methods used were: screening test for auditory processing disorder and its revised version, screening test for auditory processing, scale of auditory behaviors, children's auditory performance scale and Feather Squadron. In the Brazilian scenario, the procedures used were the simplified auditory processing assessment and Zaidan's battery of tests. At the international level, the screening test for auditory processing and Feather Squadron batteries stand out as the most comprehensive evaluation of hearing skills. At the national level, there is a paucity of studies that use methods evaluating more than four skills, and are normalized by age group. The use of simplified auditory processing assessment and questionnaires can be complementary in the search for an easy access and low-cost alternative in the auditory screening of Brazilian schoolchildren. Interactive tools should be proposed, that allow the selection of as many hearing skills as possible, validated by comparison with the battery of tests used in the diagnosis. Copyright © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

A systems neurophysiology approach to voluntary event coding.

PubMed

Petruo, Vanessa A; Stock, Ann-Kathrin; Münchau, Alexander; Beste, Christian

2016-07-15

Mechanisms responsible for the integration of perceptual events and appropriate actions (sensorimotor processes) have been subject to intense research. Different theoretical frameworks have been put forward with the "Theory of Event Coding (TEC)" being one of the most influential. In the current study, we focus on the concept of 'event files' within TEC and examine what sub-processes being dissociable by means of cognitive-neurophysiological methods are involved in voluntary event coding. This was combined with EEG source localization. We also introduce reward manipulations to delineate the neurophysiological sub-processes most relevant for performance variations during event coding. The results show that processes involved in voluntary event coding included predominantly stimulus categorization, feature unbinding and response selection, which were reflected by distinct neurophysiological processes (the P1, N2 and P3 ERPs). On a system's neurophysiological level, voluntary event-file coding is thus related to widely distributed parietal-medial frontal networks. Attentional selection processes (N1 ERP) turned out to be less important. Reward modulated stimulus categorization in parietal regions likely reflecting aspects of perceptual decision making but not in other processes. The perceptual categorization stage appears central for voluntary event-file coding. Copyright © 2016 Elsevier Inc. All rights reserved.

Correlation between central corneal thickness and visual field defects, cup to disc ratio and retinal nerve fiber layer thickness in primary open angle glaucoma patients.

PubMed

Sarfraz, Muhammad Haroon; Mehboob, Mohammad Asim; Haq, Rana Intisar Ul

2017-01-01

To evaluate the correlation between Central Corneal Thickness (CCT) and Visual Field (VF) defect parameters like Mean Deviation (MD) and Pattern Standard Deviation (PSD), Cup-to-Disc Ratio (CDR) and Retinal Nerve Fibre Layer Thickness (RNFL-T) in Primary Open-Angle Glaucoma (POAG) patients. This cross sectional study was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from September 2015 to September 2016. Sixty eyes of 30 patients with diagnosed POAG were analysed. Correlation of CCT with other variables was studied. Mean age of study population was 43.13±7.54 years. Out of 30 patients, 19 (63.33%) were males and 11 (36.67%) were females. Mean CCT, MD, PSD, CDR and RNFL-T of study population was 528.57±25.47µm, -9.11±3.07, 6.93±2.73, 0.63±0.13 and 77.79±10.44µm respectively. There was significant correlation of CCT with MD, PSD and CDR (r=-0.52, p<0.001; r=-0.59, p<0.001;r=-0.41, p=0.001 respectively). The correlation of CCT with RNFL-T was not statistically significant (r=-0.14, p=0.284). Central corneal thickness had significant correlation with visual field parameters like mean deviation and pattern standard deviation, as well as with cup-to-disc ratio. However, central corneal thickness had no significant relationship with retinal nerve fibre layer thickness.

Reframing motherhood through the culture-centered approach: articulations of agency among young Nepalese women.

PubMed

Basnyat, Iccha; Dutta, Mohan Joyti

2012-01-01

Based upon the culture-centered approach that foregrounds the relevance of interrogating the taken-for-granted assumptions that circulate in the dominant models of health communication on family planning, this article argues that traditional approaches to reproductive health campaigns are concerned with safe motherhood (e.g., fertility, birth spacing, hospital delivery) rather than with the processes through which women construct, negotiate, and maintain meanings of motherhood and health within their cultural contexts. In doing so, this traditional framework leaves out the broader sociocultural, political, and economic contexts of social structures that constrain and enable the possibilities for health in the realm of motherhood. The culture-centered approach notes the erasure of these voices of women from dominant epistemic structures, and seeks to interrupt knowledge production by co-constructing meanings of reproductive health through dialogues with women at the margins. Therefore, in-depth interviews were conducted to centralize experiences of the cultural participants, allowing alternative health meanings to emerge within their local contexts. In particular, highlighting narratives of young Nepalese women living under poverty, we are able to understand how women actively (re)construct meanings of motherhood within their localized cultural spaces.

The Ongoing Rediscovery of Après-Coup as a Central Freudian Concept.

PubMed

House, Jonathan

2017-10-01

Après-coup, Freud's Nachträglichkeit, is an essential psychoanalytic concept structuring each of four concepts, four mental processes that lie at the foundation of Freud's thinking: psychic trauma, repression, the creation of the unconscious, and the creation of infantile sexuality. It is argued here that infantile sexual drives, in contrast to the self-preservative instincts, arise from a two-step process of translation and repression in which the residues of failed translation become source-objects of the drives. These residues of failed translation have an associative resonance with adult sexuality, and the child is driven to ongoing attempts to translate them, to make them meaningful après coup. Thus, après-coup is at the heart of the human subject as a sexual creature who requires, desires, and creates meaning.

Tinnitus. I: Auditory mechanisms: a model for tinnitus and hearing impairment.

PubMed

Hazell, J W; Jastreboff, P J

1990-02-01

A model is proposed for tinnitus and sensorineural hearing loss involving cochlear pathology. As tinnitus is defined as a cortical perception of sound in the absence of an appropriate external stimulus it must result from a generator in the auditory system which undergoes extensive auditory processing before it is perceived. The concept of spatial nonlinearity in the cochlea is presented as a cause of tinnitus generation controlled by the efferents. Various clinical presentations of tinnitus and the way in which they respond to changes in the environment are discussed with respect to this control mechanism. The concept of auditory retraining as part of the habituation process, and interaction with the prefrontal cortex and limbic system is presented as a central model which emphasizes the importance of the emotional significance and meaning of tinnitus.

SIFamide in the brain of the sphinx moth, Manduca sexta.

PubMed

Heuer, C M; Binzer, Marlene; Schachtner, J

2012-01-01

SIFamides form a group of highly conserved neuropeptides in insects, crustaceans, and chelicerates. Beyond their biochemical commonalities, the neuroanatomical distribution of SIFamide in the insect nervous system also shows a remarkable degree of conservation. Thus, expression of SIFamide has been found to be restricted to four neurons of the pars intercerebralis in different holometabolous species. By means of immunohistological stainings, we here show that in Manduca sexta, those four cells are complemented by additional immunoreactive cells located in the vicinity of the mushroom body calyx. Immunopositive processes form arborizations throughout the brain, innervating major neuropils like the antennal lobes, the central complex, and the optic neuropils.

Central auditory processing disorder (CAPD) in children with specific language impairment (SLI). Central auditory tests.

PubMed

Dlouha, Olga; Novak, Alexej; Vokral, Jan

2007-06-01

The aim of this project is to use central auditory tests for diagnosis of central auditory processing disorder (CAPD) in children with specific language impairment (SLI), in order to confirm relationship between speech-language impairment and central auditory processing. We attempted to establish special dichotic binaural tests in Czech language modified for younger children. Tests are based on behavioral audiometry using dichotic listening (different auditory stimuli that presented to each ear simultaneously). The experimental tasks consisted of three auditory measures (test 1-3)-dichotic listening of two-syllable words presented like binaural interaction tests. Children with SLI are unable to create simple sentences from two words that are heard separately but simultaneously. Results in our group of 90 pre-school children (6-7 years old) confirmed integration deficit and problems with quality of short-term memory. Average rate of success of children with specific language impairment was 56% in test 1, 64% in test 2 and 63% in test 3. Results of control group: 92% in test 1, 93% in test 2 and 92% in test 3 (p<0.001). Our results indicate the relationship between disorders of speech-language perception and central auditory processing disorders.

Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography.

PubMed

Hassan, Muhammad; Sadiq, Mohammad Ali; Halim, Muhammad Sohail; Afridi, Rubbia; Soliman, Mohamed K; Sarwar, Salman; Agarwal, Aniruddha; Do, Diana V; Nguyen, Quan Dong; Sepah, Yasir Jamal

2017-01-01

To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 × 3 mm grid and a 4.5 × 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors within the inner two circles of ETDRS grid in macular region and correlated to retinal thickness of same sectors. At optic disc, VFD was calculated in six sectors based on Garway-Heath map. Area and morphology of foveal avascular zone (FAZ) was correlated with VFD in central 1 mm. The influence of myopia on mean VFD was also assessed. Twenty-four eyes (mean age: 30 years) were analyzed. Mean VFD in macular sectors was 43.5 (±4.5) and 45.8 (±5.0) % in superficial and deep retinal plexuses, respectively. Mean VFD was significantly higher in deep retinal plexus compared to superficial retinal plexus in all sectors except central 1 mm (p < 0.05). Mean VFD in central 1 mm increases with an increase in central retinal thickness in both superficial and deep retinal plexuses (p < 0.001). Mean parafoveal VFD at level of both superficial and deep retinal plexuses decrease with an increase in spherical equivalent in myopics (p < 0.05). Mean VFD in myopics was found to be significantly lower in parafoveal region of deep retinal plexus (p < 0.05). Mean area of FAZ was 0.33 (±0.15) and 0.47 mm 2 (±0.15) in superficial and deep retinal plexuses, respectively. Area of FAZ decreases with an increase in central 1 mm thickness and foveal VFD (p < 0.001). OCTA may be used to measure VFD in macular and peripapillary regions. Vessels in the parafoveal region are more densely packed in the deep retinal plexus leading to higher VFD compared to superficial plexus. Thicker retina in fovea translates into higher foveal VFD due to more compact arrangement of retinal layers and continuity of inner nuclear layer (INL). Myopia is associated with lower VFD in parafoveal region at level of deep retinal plexuses which may explain thinning of INL in myopics.

Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus.

PubMed

Patel, Dipika V; Sherwin, Trevor; McGhee, Charles N J

2006-07-01

To elucidate the structure of the human corneoscleral limbus by in vivo laser scanning confocal microscopy and to correlate limbal epithelial dimensions and density with the central epithelium and in relation to age. Fifty adult subjects were recruited into one of two age groups: younger (age<45 years) and older (age>or=45 years). Fifty left eyes of these 50 healthy subjects were examined by laser scanning in vivo confocal microscopy, to assess the basal epithelium of the central cornea and inferior limbus. Mean epithelial cell diameter, area, and density were calculated for the central basal epithelium, limbus-corneal basal epithelium, and limbus-palisade epithelium. Data were analyzed in relation to the two age groups, group A, 30+/-6 years (n=25; mean+/-SD), and group B, 60+/-11 years (n=25; P<0.01). Mean epithelial density in the limbus-cornea and limbus-palisade regions decreased significantly with age: limbus-cornea group A=7253+/-1077 cells/mm2 group B=6614+/-987 cells/mm2, P=0.03; limbus palisade group A=5409+/-799 cells/mm2, group B=5055+/-722 cells/mm2, P=0.03). Central corneal epithelial density did not change with age: group A=6162+/-503 cells/mm2, group B=6362+/-614 cells/mm2, P=0.08. Mean epithelial density was greatest at the limbus-cornea (7010+/-1081 cells/mm2) and lowest at the limbus-palisades (5289+/-847 cells/mm2). The mean width of palisade ridges was 25.0+/-6.3 microm. This is the first study to image clearly the living human corneal limbus by laser scanning in vivo confocal microscopy and to demonstrate quantitative changes in the basal epithelium with age.

Motivation enhances visual working memory capacity through the modulation of central cognitive processes.

PubMed

Sanada, Motoyuki; Ikeda, Koki; Kimura, Kenta; Hasegawa, Toshikazu

2013-09-01

Motivation is well known to enhance working memory (WM) capacity, but the mechanism underlying this effect remains unclear. The WM process can be divided into encoding, maintenance, and retrieval, and in a change detection visual WM paradigm, the encoding and retrieval processes can be subdivided into perceptual and central processing. To clarify which of these segments are most influenced by motivation, we measured ERPs in a change detection task with differential monetary rewards. The results showed that the enhancement of WM capacity under high motivation was accompanied by modulations of late central components but not those reflecting attentional control on perceptual inputs across all stages of WM. We conclude that the "state-dependent" shift of motivation impacted the central, rather than the perceptual functions in order to achieve better behavioral performances. Copyright © 2013 Society for Psychophysiological Research.

Modern-Day Demographic Processes in Central Europe and Their Potential Interactions with Climate Change

NASA Astrophysics Data System (ADS)

Bański, Jerzy

2013-01-01

The aim of this article is to evaluate the effect of contemporary transformations in the population of Central European countries on climate change, in addition to singling out the primary points of interaction between demographic processes and the climate. In analyzing the interactions between climate and demographics, we can formulate three basic hypotheses regarding the region in question: 1) as a result of current demographic trends in Central Europe, the influence of the region on its climate will probably diminish, 2) the importance of the "climatically displaced" in global migratory movements will increase, and some of those concerned will move to Central Europe, 3) the contribution of the region to global food security will increase. In the last decade most of what comprises the region of Central Europe has reported a decline in population growth and a negative migration balance. As a process, this loss of population may have a positive effect on the environment and the climate. We can expect ongoing climate change to intensify migration processes, particularly from countries outside Europe. Interactions between climate and demographic processes can also be viewed in the context of food security. The global warming most sources foresee for the coming decades is the process most likely to result in spatial polarization of food production in agriculture. Central Europe will then face the challenge of assuring and improving food security, albeit this time on a global scale.

Comprehensive protocol of traceability during IVF: the result of a multicentre failure mode and effect analysis.

PubMed

Rienzi, L; Bariani, F; Dalla Zorza, M; Albani, E; Benini, F; Chamayou, S; Minasi, M G; Parmegiani, L; Restelli, L; Vizziello, G; Costa, A Nanni

2017-08-01

Can traceability of gametes and embryos be ensured during IVF? The use of a simple and comprehensive traceability system that includes the most susceptible phases during the IVF process minimizes the risk of mismatches. Mismatches in IVF are very rare but unfortunately possible with dramatic consequences for both patients and health care professionals. Traceability is thus a fundamental aspect of the treatment. A clear process of patient and cell identification involving witnessing protocols has to be in place in every unit. To identify potential failures in the traceability process and to develop strategies to mitigate the risk of mismatches, previously failure mode and effects analysis (FMEA) has been used effectively. The FMEA approach is however a subjective analysis, strictly related to specific protocols and thus the results are not always widely applicable. To reduce subjectivity and to obtain a widespread comprehensive protocol of traceability, a multicentre centrally coordinated FMEA was performed. Seven representative Italian centres (three public and four private) were selected. The study had a duration of 21 months (from April 2015 to December 2016) and was centrally coordinated by a team of experts: a risk analysis specialist, an expert embryologist and a specialist in human factor. Principal investigators of each centre were first instructed about proactive risk assessment and FMEA methodology. A multidisciplinary team to perform the FMEA analysis was then formed in each centre. After mapping the traceability process, each team identified the possible causes of mistakes in their protocol. A risk priority number (RPN) for each identified potential failure mode was calculated. The results of the FMEA analyses were centrally investigated and consistent corrective measures suggested. The teams performed new FMEA analyses after the recommended implementations. In each centre, this study involved: the laboratory director, the Quality Control & Quality Assurance responsible, Embryologist(s), Gynaecologist(s), Nurse(s) and Administration. The FMEA analyses were performed according to the Joint Commission International. The FMEA teams identified seven main process phases: oocyte collection, sperm collection, gamete processing, insemination, embryo culture, embryo transfer and gamete/embryo cryopreservation. A mean of 19.3 (SD ± 5.8) associated process steps and 41.9 (SD ± 12.4) possible failure modes were recognized per centre. A RPN ≥15 was calculated in a mean of 6.4 steps (range 2-12, SD ± 3.60). A total of 293 failure modes were centrally analysed 45 of which were considered at medium/high risk. After consistent corrective measures implementation and re-evaluation, a significant reduction in the RPNs in all centres (RPN <15 for all steps) was observed. A simple and comprehensive traceability system was designed as the result of the seven FMEA analyses. The validity of FMEA is in general questionable due to the subjectivity of the judgments. The design of this study has however minimized this risk by introducing external experts for the analysis of the FMEA results. Specific situations such as sperm/oocyte donation, import/export and pre-implantation genetic testing were not taken into consideration. Finally, this study is only limited to the analysis of failure modes that may lead to mismatches, other possible procedural mistakes are not accounted for. Every single IVF centre should have a clear and reliable protocol for identification of patients and traceability of cells during manipulation. The results of this study can support IVF groups in better recognizing critical steps in their protocols, understanding identification and witnessing process, and in turn enhancing safety by introducing validated corrective measures. This study was designed by the Italian Society of Embryology Reproduction and Research (SIERR) and funded by the Italian National Transplant Centre (CNT) of the Italian National Institute of Health (ISS). The authors have no conflicts of interest. N/A. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Bipartite Graphs as Models of Population Structures in Evolutionary Multiplayer Games

PubMed Central

Peña, Jorge; Rochat, Yannick

2012-01-01

By combining evolutionary game theory and graph theory, “games on graphs” study the evolutionary dynamics of frequency-dependent selection in population structures modeled as geographical or social networks. Networks are usually represented by means of unipartite graphs, and social interactions by two-person games such as the famous prisoner’s dilemma. Unipartite graphs have also been used for modeling interactions going beyond pairwise interactions. In this paper, we argue that bipartite graphs are a better alternative to unipartite graphs for describing population structures in evolutionary multiplayer games. To illustrate this point, we make use of bipartite graphs to investigate, by means of computer simulations, the evolution of cooperation under the conventional and the distributed N-person prisoner’s dilemma. We show that several implicit assumptions arising from the standard approach based on unipartite graphs (such as the definition of replacement neighborhoods, the intertwining of individual and group diversity, and the large overlap of interaction neighborhoods) can have a large impact on the resulting evolutionary dynamics. Our work provides a clear example of the importance of construction procedures in games on graphs, of the suitability of bigraphs and hypergraphs for computational modeling, and of the importance of concepts from social network analysis such as centrality, centralization and bipartite clustering for the understanding of dynamical processes occurring on networked population structures. PMID:22970237

[Environmental effects of combined sewage detention tank in central Shanghai].

PubMed

Cheng, Jiang; Lü, Yong-peng; Huang, Xiao-fang; Guo, Sheng

2009-08-15

Through measuring the processes of precipitation, discharge and pollutant concentration over 20 times from 2006 to 2008 in Chendulu combined sewerage system (CSS) along Suzhou Creek in central Shanghai, the environmental effects of Chendulu combined sewage detention tank (CSDT), the first running CSDT in China, were studied. The results show that CSDT could improve CSS discharge capacity effectively with promoted interception ratio from 3.87 to 6.90-9.92. The mean annual combined sewer overflow (CSO) reduction and reduction rate are 9.10 x 10(4) m3 and 9.00%, respectively, and those of sanitary waste discharged directly to Suzhou Creek in non-rain-weather are 8.37 x 10(4) m(3) and 100% , respectively. The mean annual pollutants decrease rate of COD, BOD5, SS, NH4+ -N and TP of CSO are 13.76%, 19.69%, 15.29%, 18.24% and 15.10%, respectively, and those CSO pollutants decrease 41.21 t, 12.37 t, 50.10 t, 2.12 t and 0.29 t annually, respectively. The CSDT also could decrease sanitary waste discharged to Suzhou Creek totally, and those decreased pollutants are 20.75 t, 4.87 t, 14.90 t, 4.49 t and 0.30 t annually, respectively. The analysis shows that the CSDT design standard, running models and rainfall characteristics are the important influencing factors to realize the environmental effects of CSDT.

Centralized Authorization Using a Direct Service, Part II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wachsmann, A

Authorization is the process of deciding if entity X is allowed to have access to resource Y. Determining the identity of X is the job of the authentication process. One task of authorization in computer networks is to define and determine which user has access to which computers in the network. On Linux, the tendency exists to create a local account for each single user who should be allowed to logon to a computer. This is typically the case because a user not only needs login privileges to a computer but also additional resources like a home directory to actuallymore » do some work. Creating a local account on every computer takes care of all this. The problem with this approach is that these local accounts can be inconsistent with each other. The same user name could have a different user ID and/or group ID on different computers. Even more problematic is when two different accounts share the same user ID and group ID on different computers: User joe on computer1 could have user ID 1234 and group ID 56 and user jane on computer2 could have the same user ID 1234 and group ID 56. This is a big security risk in case shared resources like NFS are used. These two different accounts are the same for an NFS server so that these users can wipe out each other's files. The solution to this inconsistency problem is to have only one central, authoritative data source for this kind of information and a means of providing all your computers with access to this central source. This is what a ''Directory Service'' is. The two directory services most widely used for centralizing authorization data are the Network Information Service (NIS, formerly known as Yellow Pages or YP) and Lightweight Directory Access Protocol (LDAP).« less

Sediment aggradation and erosional dynamics of intermontane basins in NW Argentina

NASA Astrophysics Data System (ADS)

Bookhagen, Bodo; Castino, Fabiana; Purinton, Ben; Strecker, Manfred

2017-04-01

The NW Argentine Andes constitute the Andean Plateau (Altiplano-Puna), the second-largest orogenic plateau on Earth, an internally drained highland with a mean elevation of 4.0 ± 0.5 km (±2 sigma). The Puna is flanked by the externally drained Eastern Cordillera thrust belt and the adjacent broken foreland that are connected to the Atlantic Ocean. These mountain ranges lie in the south-central Andes and are characterized by steep topographic and climatic gradients: The first windward topographic rise east of the Puna forms a significant orographic barrier resulting in high orographic rainfall causing some of the wettest places on Earth. In contrast, the higher-elevation areas of the windward flanks become progressively drier westward, until arid conditions are attained in the central Puna. During the Quaternary the south-central Andes have repeatedly experienced significant paleoclimatic changes associated with deeper penetration of moisture into the orogen, and thus an orogenward shift of the climate gradient. This mechanism has resulted in large variations in erosion dynamics and sediment transfer toward the foreland, resulting in thick valley fills and multiple terrace levels. At much shorter timescales, climate variability during the Holocene has caused similar, yet less pronounced hydrologic trends and associated sedimentation- and erosion processes. Here, we use a time series of Digital Elevation Models (DEMs) to reconstruct land-level changes in the intramontane basins in NW Argentina. We generated the DEMs and height measurements based on stereo airphotos from the 1980s, ASTER satellite imagery, ICESat and dGPS measurements during the past decade, and several TerraSAR-X and TanDEM-X CoSSC pairs starting in 2013. Our data show a strong signal of fluvial sediment aggradation during the past 30 years, in places up to 0.5m per decade, which explains the regionally observed, modern sediment accumulation in basins that has caused major infrastructural problems. We link the increased sediment flux to cascading processes reflecting environmental and climatic changes of the southern-central Andes.

Assessment of undiscovered oil and gas resources in the North-Central Montana Province, 2017

USGS Publications Warehouse

Schenk, Christopher J.; Mercier, Tracey J.; Brownfield, Michael E.; Tennyson, Marilyn E.; Woodall, Cheryl A.; Le, Phuong A.; Klett, Timothy R.; Gaswirth, Stephanie B.; Finn, Thomas M.; Pitman, Janet K.; Marra, Kristen R.; Leathers-Miller, Heidi M.

2018-02-12

Using a geology-based assessment methodology, the U.S. Geological Survey estimated mean undiscovered, technically recoverable resources of 55 million barrels of oil and 846 billion cubic feet of gas in the North-Central Montana Province.

Central American Climatology

DTIC Science & Technology

1985-04-01

Central America, as where mean temperatures are relatively warm throughout the year de- so spite seasonal rainfall changes. 75 Elevation, solar angle...November 1982 Control Hidalgo Anos.1952-1963, Republica de Nicaragua, Ministerio de Formento Y O0.PP, Comision Nacional de Energia . Craig, Richard A., The

Development, implementation, and validation of a modeling system for the San Francisco Bay and Estuary

NASA Astrophysics Data System (ADS)

Chao, Yi; Farrara, John D.; Zhang, Hongchun; Zhang, Yinglong J.; Ateljevich, Eli; Chai, Fei; Davis, Curtiss O.; Dugdale, Richard; Wilkerson, Frances

2017-07-01

A three-dimensional numerical modeling system for the San Francisco Bay is presented. The system is based on an unstructured grid numerical model known as Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM). The lateral boundary condition is provided by a regional coastal ocean model. The surface forcing is provided by a regional atmospheric model. The SCHISM results from a decadal hindcast run are compared with available tide gauge data, as well as a collection of temperature and salinity profiles. An examination of the observed climatological annual mean salinities at the United States Geological Survey (USGS) stations shows the highest salinities to be in the open ocean and the lowest well north (upstream) of the Central Bay, a pattern that does not change substantially with season. The corresponding mean SCHISM salinities reproduced the observed variations with location quite well, though with a fresh bias. The lowest values within the Bay occur during spring and the highest values during autumn, mirroring the seasonal variations in river discharge. The corresponding observed mean temperatures within the Bay were 2 to 3° C cooler in the Central Bay than to either the north or south. This observed pattern of a cooler Central Bay was not particularly well reproduced in the SCHISM results, which also showed a cold bias. Examination of the seasonal means revealed that the cool Central Bay pattern is found only during summer in the SCHISM results. The persistent cold and fresh biases in the model control run were nearly eliminated in a sensitivity run with modifications to the surface heat flux and river discharge. The surface atmospheric forcing and the heat flux at the western boundary are found to be the two major terms in a SCHISM-based heat budget analysis of the mean seasonal temperature cycle for the Central Bay. In the Central Bay salt budget, freshwater discharged by rivers into upstream portions of the Bay to the north balanced by the influx of salt from the west are the primary drivers of the mean seasonal salinity cycle. Concerning the interannual variability in temperatures, the warm anomalies during the period 2014-16 were the strongest and most persistent departures from normal during the period analyzed and were realistically reproduced by SCHISM. The most prominent salinity anomalies in both the observations and SCHISM results were the salty anomalies that persisted for most of the four-year California drought of 2012-2015.

Product and Process, Literacy and Orality: An Essay on Composition and Culture.

ERIC Educational Resources Information Center

Killingsworth, M. Jimmie

1993-01-01

Argues that two oppositions (product versus process, literacy versus orality) bear a special relationship to one another resembling a ratio. Relates product and literacy to centralized authority, and relates process and orality to open-minded exchange, thus evoking the central dilemma of modern culture. (HB)

Central Processing Dysfunctions in Children: A Review of Research.

ERIC Educational Resources Information Center

Chalfant, James C.; Scheffelin, Margaret A.

Research on central processing dysfunctions in children is reviewed in three major areas. The first, dysfunctions in the analysis of sensory information, includes auditory, visual, and haptic processing. The second, dysfunction in the synthesis of sensory information, covers multiple stimulus integration and short-term memory. The third area of…

Enhanced seasonal predictability of the summer mean temperature in Central Europe favored by new dominant weather patterns

NASA Astrophysics Data System (ADS)

Hoffmann, P.

2018-04-01

In this study two complementary approaches have been combined to estimate the reliability of the data-driven seasonal predictability of the meteorological summer mean temperature (T_{JJA}) over Europe. The developed model is based on linear regressions and uses early season predictors to estimate the target value T_{JJA}. We found for the Potsdam (Germany) climate station that the monthly standard deviations (σ) from January to April and the temperature mean ( m) in April are good predictors to describe T_{JJA} after 1990. However, before 1990 the model failed. The core region where this model works is the north-eastern part of Central Europe. We also analyzed long-term trends of monthly Hess/Brezowsky weather types as possible causes of the dynamical changes. In spring, a significant increase of the occurrences for two opposite weather patterns was found: Zonal Ridge across Central Europe (BM) and Trough over Central Europe (TRM). Both currently make up about 30% of the total alternating weather systems over Europe. Other weather types are predominantly decreasing or their trends are not significant. Thus, the predictability may be attributed to these two weather types where the difference between the two Z500 composite patterns is large. This also applies to the north-eastern part of Central Europe. Finally, the detected enhanced seasonal predictability over Europe is alarming, because severe side effects may occur. One of these are more frequent climate extremes in summer half-year.

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

PubMed Central

2011-01-01

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids). PMID:21542893

T-cell homeostasis in breast cancer survivors with persistent fatigue.

PubMed

Bower, Julienne E; Ganz, Patricia A; Aziz, Najib; Fahey, John L; Cole, Steve W

2003-08-06

Approximately 30% of women successfully treated for breast cancer suffer persistent fatigue of unknown origin. Recent studies linking inflammatory processes to central nervous system-mediated fatigue led us to examine cellular immune system status in 20 fatigued breast cancer survivors and 19 matched non-fatigued breast cancer survivors. Fatigued survivors, compared with non-fatigued survivors, had statistically significantly increased numbers of circulating T lymphocytes (mean 31% increase, 95% confidence interval [CI] = 6% to 56%; P =.015 by two-sided analysis of variance [ANOVA]), with pronounced elevation in the numbers of CD4+ T lymphocytes (mean 41% increase, 95% CI = 15% to 68%; P =.003 by two-sided ANOVA) and CD56+ effector T lymphocytes (mean 52% increase, 95% CI = 4% to 99%; P =.027 by two-sided ANOVA). These changes were independent of patient demographic and treatment characteristics. Absolute numbers of B cells, natural killer cells, granulocytes, and monocytes were not altered. The increased numbers of circulating T cells correlated with elevations in the level of serum interleukin 1 receptor antagonist (for CD3+ cells, r =.56 and P =.001; for CD3+/CD4+ cells, r =.68 and P<.001, by Spearman rank correlation). Results of this study suggest that persistent fatigue in breast cancer survivors might be associated with a chronic inflammatory process involving the T-cell compartment. These results require confirmation in a larger study that is specifically designed to address this hypothesis.

Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study

PubMed Central

Raschpichler, Matthias; Straatman, Kees; Schroeter, Matthias Leopold; Arelin, Katrin; Schlögl, Haiko; Fritzsch, Dominik; Mende, Meinhard; Pampel, André; Böttcher, Yvonne; Stumvoll, Michael; Villringer, Arno; Mueller, Karsten

2013-01-01

Objectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age. Design Cross-sectional, exploratory. Setting University Clinic, Integrative Research and Treatment Centre. Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women). Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC). Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. This negative correlation disappeared in the elderly. Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT. Conclusions Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected. PMID:23355665

Extending the amygdala in theories of threat processing

PubMed Central

Fox, Andrew S.; Oler, Jonathan A.; Tromp, Do P.M.; Fudge, Julie L.; Kalin, Ned H.

2015-01-01

The central extended amygdala is an evolutionarily conserved set of interconnected brain regions that play an important role in threat processing to promote survival. Two core components of the central extended amygdala, the central nucleus of the amygdala (Ce) and the lateral bed nucleus of the stria terminalis (BST) are highly similar regions that serve complimentary roles by integrating fear- and anxiety-relevant information. Survival depends on the central extended amygdala's ability to rapidly integrate and respond to threats that vary in their immediacy, proximity, and characteristics. Future studies will benefit from understanding alterations in central extended amygdala function in relation to stress-related psychopathology. PMID:25851307

Grandparenthood: An Overview of Meaning and Mental Health.

ERIC Educational Resources Information Center

Kivnick, Helen Q.

1982-01-01

Explored the meaning of grandparenthood to grandparents, the importance of grandparenthood across the life cycle, and the relationship between grandparenthood and mental health. Derived five dimensions of grandparenthood meaning: (1) centrality, (2) valued elder, (3) immortality through clan, (4) reinvolvement with personal past, and (5) spoil.…

Treatment of severe radial club hand by distraction using an articulated mini-rail fixator and transfixing pins.

PubMed

Romana, C; Ciais, G; Fitoussi, F

2015-06-01

Treatment of severe radial club hand is difficult. Several authors have emphasized the importance of preliminary soft-tissue distraction before centralization. Treatment of severe radial club hand by articulated mini-rail allowing prior soft-tissue distraction improves results. Thirteen patients were treated sequentially, with an initial step of distraction and a second step of centralization. The first step consisted in fitting 2 mini-fixators, one in the concavity and the other in the convexity of the deformity. Four transfixing wires through the ulna and metacarpal bone connected the 2 fixators. After this preliminary distraction, the fixator was removed and a centralization wire was introduced percutaneously, with ulnar osteotomy if necessary. Sagittal and coronal correction was measured on the angle between forearm and hand. Mean age at treatment was 37.5 months (range, 9-120 months). Mean distraction time was 53.2 days (26-90 days). Ulnar osteotomy was required in 8 cases (61%). There were no major complications requiring interruption of distraction. Sagittal and coronal correction after centralization reduced mean residual forearm/hand angulation to<12°. Soft-tissue distraction in the concavity ahead of centralization is essential to good correction, avoiding extensive soft-tissue release and hyperpressure on the distal ulnar growth plate. There have been several studies of distraction; the present technique, associating 2 mini-fixators connected by threaded K-wires, provided sufficient distraction in the concavity of the deformity to allow satisfactory correction in all cases. Subsequent complications (breakage or displacement of the centralization wires) testify to the complexity of long-term management. The present study confirms the interest of a preliminary soft-tissue distraction step in treating severe radial club hand. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Perceptual load-dependent neural correlates of distractor interference inhibition.

PubMed

Xu, Jiansong; Monterosso, John; Kober, Hedy; Balodis, Iris M; Potenza, Marc N

2011-01-18

The load theory of selective attention hypothesizes that distractor interference is suppressed after perceptual processing (i.e., in the later stage of central processing) at low perceptual load of the central task, but in the early stage of perceptual processing at high perceptual load. Consistently, studies on the neural correlates of attention have found a smaller distractor-related activation in the sensory cortex at high relative to low perceptual load. However, it is not clear whether the distractor-related activation in brain regions linked to later stages of central processing (e.g., in the frontostriatal circuits) is also smaller at high rather than low perceptual load, as might be predicted based on the load theory. We studied 24 healthy participants using functional magnetic resonance imaging (fMRI) during a visual target identification task with two perceptual loads (low vs. high). Participants showed distractor-related increases in activation in the midbrain, striatum, occipital and medial and lateral prefrontal cortices at low load, but distractor-related decreases in activation in the midbrain ventral tegmental area and substantia nigra (VTA/SN), striatum, thalamus, and extensive sensory cortices at high load. Multiple levels of central processing involving midbrain and frontostriatal circuits participate in suppressing distractor interference at either low or high perceptual load. For suppressing distractor interference, the processing of sensory inputs in both early and late stages of central processing are enhanced at low load but inhibited at high load.

The Interaction between Central and Peripheral Processing in Chinese Handwritten Production: Evidence from the Effect of Lexicality and Radical Complexity

PubMed Central

Zhang, Qingfang; Feng, Chen

2017-01-01

The interaction between central and peripheral processing in written word production remains controversial. This study aims to investigate whether the effects of radical complexity and lexicality in central processing cascade into peripheral processing in Chinese written word production. The participants were asked to write characters and non-characters (lexicality) with different radical complexity (few- and many-strokes). The findings indicated that regardless of the lexicality, the writing latencies were longer for characters with higher complexity (the many-strokes condition) than for characters with lower complexity (the few-strokes condition). The participants slowed down their writing execution at the radicals' boundary strokes, which indicated a radical boundary effect in peripheral processing. Interestingly, the lexicality and the radical complexity affected the pattern of shift velocity and writing velocity during the execution of writing. Lexical processing cascades into peripheral processing but only at the beginning of Chinese characters. In contrast, the radical complexity influenced the execution of handwriting movement throughout the entire character, and the pattern of the effect interacted with the character frequency. These results suggest that the processes of the lexicality and the radical complexity function during the execution of handwritten word production, which suggests that central processing cascades over peripheral processing during Chinese characters handwriting. PMID:28348536

Surgical Outcomes of Idiopathic Epiretinal Membrane: the Gülhane Experience.

PubMed

Akıncıoğlu, Dorukcan; Özge, Gökhan; Küçükevcilioğlu, Murat; Erdurman, Fazıl Cüneyt; Durukan, Ali Hakan

2018-04-01

We aimed to report our experiences and outcomes of vitreoretinal surgery in idiopathic epiretinal membrane. We retrospectively reviewed patients who underwent vitreoretinal surgery for idiopathic epiretinal membrane between January 2012 and 2014. The patients' pre- and postoperative visual acuity, slit-lamp examination findings, and optical coherence tomography (OCT) images were evaluated. Forty-five eyes of 45 patients (36% male, 64% female) were included (mean age, 69±8.2 years). Mean postoperative follow-up time was 7±4 (1-12) months. The mean preoperative logMAR best corrected visual acuity was 0.58±0.32 and postoperatively 0.40±0.31, 0.33±0.33, 0.28±0.34 respectively at 3, 6, and 12 months. All OCT parameters showed statistically significant anatomical improvement at 1, 3, 6, and 12 months. Correlation analysis showed that central macular thickness (r=0.69, p<0.05) and central macular volume (r=0.69, p<0.05) were the only parameters that had strong positive correlations with visual improvement. Epiretinal membrane causes heterogeneous anatomical changes in the macula for every patient. Therefore, a correlation between visual gain and changes in central macular thickness could not yet be demonstrated. We believe that central macular volume may be a better parameter for following these patients.

On self-identity: the process of inclusion of individuals with intellectual disabilities in the military.

PubMed

Werner, Shirli; Hochman, Yael

2018-02-23

Identity development among individuals with disabilities may depend on their being included in central institutions in society. The centrality of the military in Israeli society makes it a highly important setting for inclusion and identity development. We examined the self-identity of young adults with intellectual disabilities who serve in the "Equal in Uniform" project. Forty-nine interviews were conducted with 31 individuals with intellectual disabilities. Findings showed that military service helped develop the identity of soldiers, which enhanced their self-efficacy. Participants described their participation in the military as an opportunity to take an active part in socially valued roles. Findings are discussed with reference to the effect of the project on the self-identity of individuals with intellectual disabilities. The meaning of successfully serving in socially valued roles for self-efficacy is discussed. Implications for rehabilitation Completing socially valued roles leads to greater self-efficacy, enhanced self-esteem and greater psychological well-being among individuals with intellectual disabilities. Inclusion of individuals with intellectual disabilities within a central community setting (specifically the military) allows them to deal with issues of identity development, as it does for other young people without intellectual disabilities. Receiving ongoing positive input from others for one's abilities and success is a conducive factor in positive identity formation.

Large incidence angle and defocus influence cat's eye retro-reflector

NASA Astrophysics Data System (ADS)

Zhang, Lai-xian; Sun, Hua-yan; Zhao, Yan-zhong; Yang, Ji-guang; Zheng, Yong-hui

2014-11-01

Cat's eye lens make the laser beam retro-reflected exactly to the opposite direction of the incidence beam, called cat's eye effect, which makes rapid acquiring, tracking and pointing of free space optical communication possible. Study the influence of cat's eye effect to cat's eye retro-reflector at large incidence angle is useful. This paper analyzed the process of how the incidence angle and focal shit affect effective receiving area, retro-reflected beam divergence angle, central deviation of cat's eye retro-reflector at large incidence angle and cat's eye effect factor using geometrical optics method, and presented the analytic expressions. Finally, numerical simulation was done to prove the correction of the study. The result shows that the efficiency receiving area of cat's eye retro-reflector is mainly affected by incidence angle when the focal shift is positive, and it decreases rapidly when the incidence angle increases; the retro-reflected beam divergence and central deviation is mainly affected by focal shift, and within the effective receiving area, the central deviation is smaller than beam divergence in most time, which means the incidence beam can be received and retro-reflected to the other terminal in most time. The cat's eye effect factor gain is affected by both incidence angle and focal shift.

Central Auditory Processing through the Looking Glass: A Critical Look at Diagnosis and Management.

ERIC Educational Resources Information Center

Young, Maxine L.

1985-01-01

The article examines the contributions of both audiologists and speech-language pathologists to the diagnosis and management of students with central auditory processing disorders and language impairments. (CL)

Wildlife-associated recreation in the North Central Region: participation patterns and management implications

Treesearch

Allan Marsinko; John Dwyer

2002-01-01

The North Central Region (IA, IL, IN, MI, MN, MO, WI) is a diverse area of the United States. Compared to the remainder of the country, the region as a whole is demographically similar in terms of mean age, education, household income, and gender. However, the North Central region has a higher proportion of Whites and a slightly lower proportion of people residing in...

East Europe Report

DTIC Science & Technology

1986-07-22

trust’s system and by Kiril Zarev, BCP Central Committee secretary, Vasil Kalaydzhiev, secretary of the Central Committee of our trade union, and... Dimitrov and Bobov Dol combines, by 300,000 cubic meters each. We are not satisfied with the results of the organization and the efforts made by...institutes on the problems under discussion, Kiril Zarev, BCP Central Committee secretary, shared his thoughts on the ways and means for the successful

Stable Isotopes as Indicators of Groundwater Recharge Mechanisms in Arid and Semi-arid Australia

NASA Astrophysics Data System (ADS)

Harrington, G. A.; Herczeg, A. L.

2001-05-01

The isotopic compositions of soil water and groundwaters in arid and semi-arid zones are always different from the mean composition of rainfall. Although evaporative processes always remove the lighter isotopes (1H and 16O) to the vapour phase, arid zone groundwaters are invariably depleted in the heavy isotopes (2H and 18O) relative to mean present day rainfall. We compare two sites, one in semi-arid South Australia and the other in arid Central Australia that have a similar mean annual rainfall (250 to 300 mm/a), very high potential evapotranspiration (2500 and 3500 mm/a respectively) but very different rainfall patterns (winter dominated versus summer monsoonal). We aim to evaluate whether inferences from groundwater \\delta2H and \\delta18O reveal information about palaeorecharge, or recharge mechanisms or a combination of both. Recharge to the unconfined limestone aquifer in the Mallee area of South Australia occurs annually via widespread (diffuse) infiltration of winter dominant rainfall. This process is reflected in soil and groundwater isotopic compositions that plot relatively close to both the Local Meteoric Water Line and the volume-weighted mean composition of winter rainfall, and have a deuterium excess (\\delta2H-8.\\delta18O) of between +2 and +8 for the freshest samples. Groundwater recharge to the arid Ti-Tree Basin occurs predominantly by inputs of partially-evaporated surface water from ephemeral rivers and flood-plains following rare, high-intensity storms that are derived from monsoonal activity to the north of Australia. These extreme events result in groundwater and soil water stable isotope compositions being significantly depleted in the heavy isotopes relative to the mean composition of rainfall and a deuterium excess of between minus 8 and +3 in the freshest groundwaters.

Centralization or decentralization of facial structures in Korean young adults.

PubMed

Yoo, Ja-Young; Kim, Jeong-Nam; Shin, Kang-Jae; Kim, Soon-Heum; Choi, Hyun-Gon; Jeon, Hyun-Soo; Koh, Ki-Seok; Song, Wu-Chul

2013-05-01

It is well known that facial beauty is dictated by facial type, and harmony between the eyes, nose, and mouth. Furthermore, facial impression is judged according to the overall facial contour and the relationship between the facial structures. The aims of the present study were to determine the optimal criteria for the assessment of gathering or separation of the facial structures and to define standardized ratios for centralization or decentralization of the facial structures.Four different lengths were measured, and 2 indexes were calculated from standardized photographs of 551 volunteers. Centralization and decentralization were assessed using the width index (interpupillary distance / facial width) and height index (eyes-mouth distance / facial height). The mean ranges of the width index and height index were 42.0 to 45.0 and 36.0 to 39.0, respectively. The width index did not differ with sex, but males had more decentralized faces, and females had more centralized faces, vertically. The incidence rate of decentralized faces among the men was 30.3%, and that of centralized faces among the women was 25.2%.The mean ranges in width and height indexes have been determined in a Korean population. Faces with width and height index scores under and over the median ranges are determined to be "centralized" and "decentralized," respectively.

Finasteride for chronic central serous chorioretinopathy.

PubMed

Forooghian, Farzin; Meleth, Annal D; Cukras, Catherine; Chew, Emily Y; Wong, Wai T; Meyerle, Catherine B

2011-04-01

To evaluate the safety and efficacy of finasteride, an inhibitor of dihydrotestosterone synthesis, in the treatment of chronic central serous chorioretinopathy. Five patients with chronic central serous chorioretinopathy were prospectively enrolled in this pilot study. Patients were administered finasteride (5 mg) daily for 3 months, after which study medication was withheld and patients were observed for 3 months. Main outcome measures included best-corrected visual acuity, central subfield macular thickness, and subretinal fluid volume as assessed by optical coherence tomography. Serum dihydrotestosterone, serum testosterone, and urinary cortisol were also measured. There was no change in mean best-corrected visual acuity. Mean center-subfield macular thickness and subretinal fluid volume reached a nadir at 3 months and rose to levels that were below baseline by 6 months. The changes in both optical coherence tomography parameters paralleled those in serum dihydrotestosterone level. In four patients, center-subfield macular thickness and/or subretinal fluid volume increased after discontinuation of finasteride. In the remaining patient, both optical coherence tomography parameters normalized with finasteride and remained stable when the study medication was discontinued. Finasteride may represent a novel medical treatment for chronic central serous chorioretinopathy. Larger controlled clinical trials are needed to further assess the efficacy of finasteride for the treatment of central serous chorioretinopathy.

Color-coded topography and shaded relief map of the lunar near side and far side hemispheres

USGS Publications Warehouse

,

2003-01-01

This publication is a set of three sheets of topographic maps that presents color-coded topographic data digitally merged with shaded relief data. Adopted figure: The figure for the Moon, used for the computation of the map projection, is a sphere with a radius of 1737.4 km. Because the Moon has no surface water, and hence no sea level, the datum (the 0 km contour) for elevations is defined as the radius of 1737.4 km. Coordinates are based on the mean Earth/polar axis (M.E.) coordinates system, the z axis is the axis of the Moon's rotation, and the x axis is the mean Earth direction. The center of mass is the origin of the coordinate system. The equator lies in the x-y plane and the prime meridian lies in the x-z plane with east longitude values being positive. Projection: The projection is Lambert Azimuthal Equal Area Projection. The scale factor at the central latitude and central longitude point is 1:10,000,000. For the near side hemisphere the central latitude and central longitude point is at 0° and 0°. For the far side hemisphere the central latitude and central longitude point is at 0° and 180°.

Total arsenic in raw and boiled portions of Norway lobster (Nephrops norvegicus) from the central Adriatic Sea.

PubMed

Visciano, Pierina; Perugini, Monia; Manera, Maurizio; Abete, Maria Cesarina; Tarasco, Renata; Salese, Carmine; Amorena, Michele

2013-12-18

The distribution of total arsenic in different portions of Norway lobster (Nephrops norvegicus L., Crustacea) was studied both in fresh samples and after a boiling process. All individuals (n = 80) were selected of medium standard commercial size (13-15 cm). The highest mean concentrations (26.86 ± 1.57 mg/kg wet weight (ww)) were found in the raw brown meat of the crustacean, probably due to its detoxification role, whereas the lowest mean values (15.97 ± 0.85 mg/kg ww) were in the raw exoskeleton. The raw white meat reported mean values of 16.09 ± 0.61 mg/kg ww. The levels of arsenic contamination detected in the boiled portions showed a significant (p < 0.01) decrease compared to the raw portions, as a consequence of solubilization phenomena. In fact, a large amount of arsenic from raw lobsters was transferred to the corresponding boiling broth. In the most commonly consumed portion, the white meat, only slight losses (7.22%) in total arsenic content were observed compared to the raw portion.

Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification.

PubMed

Weller, Harold N; Nirschl, David S; Paulson, James L; Hoffman, Steven L; Bullock, William H

2012-09-10

The use of standardized lean manufacturing principles to improve drug discovery productivity is often thought to be at odds with fostering innovation. This manuscript describes how selective implementation of a lean optimized process, in this case centralized purification for medicinal chemistry, can improve operational productivity and increase scientist time available for innovation. A description of the centralized purification process is provided along with both operational and impact (productivity) metrics, which indicate lower cost, higher output, and presumably more free time for innovation as a result of the process changes described.

From Wagons to Race Cars, At Least Now We Have A Chassis

NASA Astrophysics Data System (ADS)

Morrow, A. L.

2003-12-01

For the past 30 years Very-Long-Baseline Interferometry (VLBI) has provided astronomers with the most accurate measurements to date of both distant radio sources as well as the tectonic plates. The resolutions attainable through VLBI are orders of magnitude better than other instruments. In order to transmit radio signals collected at different sites to a correlator for processing the VLBI data was stored on magnetic tapes, and then the magnetic tapes were shipped through the mail to the central processing site. This was not only arduous and inefficient, it was also costly. Now this means of shipment can be replaced by global high speed networks. This means of transmission is called e-VLBI. New protocols must be developed so e-VLBI can become a proficient high bandwidth background user. The protocol agreed upon uses a Real-time Transport Protocol (RTP) framework to preserve timing information and synchronization. The RTP is then transported using the Internet User Datagram Protocol (UDP) with RTP Control Protocol (RTCP) monitoring the networks performance. When this protocol is fully functional astronomers will be able to observe all over the world and receive results in real time.

Motor Variability Arises from a Slow Random Walk in Neural State

PubMed Central

Chaisanguanthum, Kris S.; Shen, Helen H.

2014-01-01

Even well practiced movements cannot be repeated without variability. This variability is thought to reflect “noise” in movement preparation or execution. However, we show that, for both professional baseball pitchers and macaque monkeys making reaching movements, motor variability can be decomposed into two statistical components, a slowly drifting mean and fast trial-by-trial fluctuations about the mean. The preparatory activity of dorsal premotor cortex/primary motor cortex neurons in monkey exhibits similar statistics. Although the neural and behavioral drifts appear to be correlated, neural activity does not account for trial-by-trial fluctuations in movement, which must arise elsewhere, likely downstream. The statistics of this drift are well modeled by a double-exponential autocorrelation function, with time constants similar across the neural and behavioral drifts in two monkeys, as well as the drifts observed in baseball pitching. These time constants can be explained by an error-corrective learning processes and agree with learning rates measured directly in previous experiments. Together, these results suggest that the central contributions to movement variability are not simply trial-by-trial fluctuations but are rather the result of longer-timescale processes that may arise from motor learning. PMID:25186752

Central Component Descriptors for Levels of Technological Pedagogical Content Knowledge

ERIC Educational Resources Information Center

Niess, Margaret L.

2013-01-01

Technological pedagogical content knowledge (TPACK) proposes a theoretical framework that incorporates four central components: an overarching conception of what it means to teach with technology, knowledge of students' thinking and understandings of specific topics with technologies, knowledge of curricular materials that incorporate…

Assessment of coalbed gas resources of the Central and South Sumatra Basin Provinces, Indonesia, 2016

USGS Publications Warehouse

Schenk, Christopher J.; Klett, Timothy R.; Tennyson, Marilyn E.; Mercier, Tracey J.; Brownfield, Michael E.; Pitman, Janet K.; Gaswirth, Stephanie B.; Finn, Thomas M.

2016-12-09

Using a geology-based assessment methodology, the U.S. Geological Survey estimated a mean of 20 trillion cubic feet of undiscovered, technically recoverable coalbed gas resource in the Central and South Sumatra Basin Provinces of Indonesia.

Assessment of shale-oil resources of the Central Sumatra Basin, Indonesia, 2015

USGS Publications Warehouse

Schenk, Christopher J.; Charpentier, Ronald R.; Klett, Timothy R.; Tennyson, Marilyn E.; Mercier, Tracey J.; Brownfield, Michael E.; Pitman, Janet K.; Gaswirth, Stephanie B.; Leathers-Miller, Heidi M.

2015-11-12

Using a geology-based assessment methodology, the U.S. Geological Survey estimated means of 459 million barrels of shale oil, 275 billion cubic feet of associated gas, and 23 million barrels of natural gas liquids in the Central Sumatra Basin, Indonesia.

The effect of low versus high approach-motivated positive affect on memory for peripherally versus centrally presented information.

PubMed

Gable, Philip A; Harmon-Jones, Eddie

2010-08-01

Emotions influence attention and processes involved in memory. Although some research has suggested that positive affect categorically influences these processes differently than neutral affect, recent research suggests that motivational intensity of positive affective states influences these processes. The present experiments examined memory for centrally or peripherally presented information after the evocation of approach-motivated positive affect. Experiment 1 found that, relative to neutral conditions, pregoal, approach-motivated positive affect (caused by a monetary incentives task) enhanced memory for centrally presented information, whereas postgoal, low approach-motivated positive affect enhanced memory for peripherally presented information. Experiment 2 found that, relative to a neutral condition, high approach-motivated positive affect (caused by appetitive pictures) enhanced memory for centrally presented information but hindered memory for peripheral information. These results suggest a more complex relationship between positive affect and memory processes and highlight the importance of considering the motivational intensity of positive affects in cognitive processes. Copyright 2010 APA

Stress and tension-type headache mechanisms.

PubMed

Cathcart, Stuart; Winefield, Anthony H; Lushington, Kurt; Rolan, Paul

2010-10-01

Stress is widely demonstrated as a contributing factor in tension-type headache (TTH). The mechanisms underlying this remain unclear at present. Recent research indicates the importance of central pain processes in tension-type headache (TTH) pathophysiology. Concurrently, research with animals and healthy humans has begun to elucidate the relationship between stress and pain processing in the central nervous system, including central pain processes putatively dysfunctional in TTH. Combined, these two fields of research present new insights and hypotheses into possible mechanisms by which stress may contribute to TTH. To date, however, there has been no comprehensive review of this literature. The present paper provides such a review, which may be valuable in facilitating a broader understanding of the central mechanisms by which stress may contribute to TTH.

50 CFR 300.101 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... returns to port and at all points in between. Real-time means as soon as possible, but at least every 4... paragraph (1) of this definition. Centralized Vessel Monitoring System (C-VMS) means a system that uses... weight, at any time, of the catch on board the vessel. Dissostichus catch document (DCD) means the...

50 CFR 300.101 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... returns to port and at all points in between. Real-time means as soon as possible, but at least every 4... paragraph (1) of this definition. Centralized Vessel Monitoring System (C-VMS) means a system that uses... weight, at any time, of the catch on board the vessel. Dissostichus catch document (DCD) means the...

A Unifying Probability Example.

ERIC Educational Resources Information Center

Maruszewski, Richard F., Jr.

2002-01-01

Presents an example from probability and statistics that ties together several topics including the mean and variance of a discrete random variable, the binomial distribution and its particular mean and variance, the sum of independent random variables, the mean and variance of the sum, and the central limit theorem. Uses Excel to illustrate these…

50 CFR 300.101 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... returns to port and at all points in between. Real-time means as soon as possible, but at least every 4... paragraph (1) of this definition. Centralized Vessel Monitoring System (C-VMS) means a system that uses... weight, at any time, of the catch on board the vessel. Dissostichus catch document (DCD) means the...

Negotiation for Meaning and Peer Assistance in Second Language Classrooms

ERIC Educational Resources Information Center

Foster, Pauline; Ohta, Amy Snyder

2005-01-01

This paper investigates the value of language classroom negotiation of meaning from both cognitive and sociocultural perspectives. According to Long (1985, 1996) comprehensible input gained through interactional adjustments such as negotiating meaning and modifying output is central to second language acquisition, and much research has been…

Testing the Predictions of the Central Capacity Sharing Model

ERIC Educational Resources Information Center

Tombu, Michael; Jolicoeur, Pierre

2005-01-01

The divergent predictions of 2 models of dual-task performance are investigated. The central bottleneck and central capacity sharing models argue that a central stage of information processing is capacity limited, whereas stages before and after are capacity free. The models disagree about the nature of this central capacity limitation. The…

Using multiplicity as a fractional cross-section estimation for centrality in PHOBOS

NASA Astrophysics Data System (ADS)

Hollis, Richard S.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Chai, Z.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Halliwell, C.; Hamblen, J.; Hauer, M.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Holylnski, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Wenger, E.; Wolfs, F. L. H.; Wosiek, B.; Wozniak, K.; Wyslouch, B.; PHOBOS Collaboration

2005-01-01

Collision centrality is a valuable parameter used in relativistic nuclear physics which relates to geometrical quantities such as the number of participating nucleons. PHOBOS utilizes a multiplicity measurement as a means to estimate fractional cross-section of a collision event-by-event. From this, the centrality of this collision can be deduced. The details of the centrality determination depend both on the collision system and collision energy. Presented here are the techniques developed over the course of the RHIC program that are used by PHOBOS to extract the centrality. Possible biases that have to be overcome before a final measurement can be interpreted are discussed.

Why Deming and OBE Don't Mix.

ERIC Educational Resources Information Center

Holt, Maurice

1995-01-01

The central idea in W. Edwards Deming's approach to quality management is the need to improve process. Outcome-based education's central defect is its failure to address process. Deming would reject OBE along with management-by-objectives. Education is not a product defined by specific output measures, but a process to develop the mind. (MLH)

Centralized processing of contact-handled TRU waste feasibility analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-12-01

This report presents work for the feasibility study of central processing of contact-handled TRU waste. Discussion of scenarios, transportation options, summary of cost estimates, and institutional issues are a few of the subjects discussed. (JDL)

Replication of self-centering optical fiber alignment structures using hot embossing

NASA Astrophysics Data System (ADS)

Ebraert, Evert; Wissmann, Markus; Barié, Nicole; Guttmann, Markus; Schneider, Marc; Kolew, Alexander; Worgull, Matthias; Beri, Stefano; Watté, Jan; Thienpont, Hugo; Van Erps, Jürgen

2016-04-01

With the demand for broadband connectivity on the rise due to various services like video-on-demand and cloud computing becoming more popular, the need for better connectivity infrastructure is high. The only future- proof option to supply this infrastructure is to deploy "fiber to the home" (FTTH) networks. One of the main difficulties with the deployment of FTTH is the vast amount of single-mode fiber (SMF) connections that need to be made. Hence there is a strong need for components which enable high performance, robust and easy-to- use SMF connectors. Since large-scale deployment is the goal, these components should be mass-producible at low cost. We discuss a rapid prototyping process on the basis of hot embossing replication of a self-centering alignment system (SCAS) based on three micro-springs, which can position a SMF independently of its diameter. This is beneficial since there is a fabrication tolerance of up to +/-1 μm on a standard G.652 SMF's diameter that can lead to losses if the outer diameter is used as a reference for alignment. The SCAS is first prototyped with deep proton writing (DPW) in polymethylmethacrylate (PMMA) after which it is glued to a copper substrate with an adhesive. Using an electroforming process, a nickel block is grown over the PMMA prototype followed by mechanical finishing to fabricate a structured nickel mould insert. Even though the mould insert shows non- ideal and rounded features it is used to create PMMA replicas of the SCAS by means of hot embossing. The SCAS possesses a central opening in which a bare SMF can be clamped, which is designed with a diameter of 121 μm. PMMA replicas are dimensionally characterized using a multisensor coordinate measurement machine and show a central opening diameter of 128.3 +/- 2.8 μm. This should be compared to the central opening diameter of the DPW prototype used for mould formation which was measured to be 120.5 μm. This shows that the electroforming and subsequent replication process is possible for complex micro-scale components and could be accurate after optimisation. We characterized the sidewall roughness of PMMA replicas using a non- contact optical profiler, resulting in a root-mean-square roughness of 48 nm over an area of 63.7 μm×47.8 μm. This low sidewall roughness is especially important in the replication of high aspect ratio structures to facilitate demoulding since the sidewalls cause the most friction with the mould insert.

Method and apparatus for fault tolerance

NASA Technical Reports Server (NTRS)

Masson, Gerald M. (Inventor); Sullivan, Gregory F. (Inventor)

1993-01-01

A method and apparatus for achieving fault tolerance in a computer system having at least a first central processing unit and a second central processing unit. The method comprises the steps of first executing a first algorithm in the first central processing unit on input which produces a first output as well as a certification trail. Next, executing a second algorithm in the second central processing unit on the input and on at least a portion of the certification trail which produces a second output. The second algorithm has a faster execution time than the first algorithm for a given input. Then, comparing the first and second outputs such that an error result is produced if the first and second outputs are not the same. The step of executing a first algorithm and the step of executing a second algorithm preferably takes place over essentially the same time period.

An Architecture for Autonomic Web Service Process Planning

NASA Astrophysics Data System (ADS)

Moore, Colm; Xue Wang, Ming; Pahl, Claus

Web service composition is a technology that has received considerable attention in the last number of years. Languages and tools to aid in the process of creating composite Web services have been received specific attention. Web service composition is the process of linking single Web services together in order to accomplish more complex tasks. One area of Web service composition that has not received as much attention is the area of dynamic error handling and re-planning, enabling autonomic composition. Given a repository of service descriptions and a task to complete, it is possible for AI planners to automatically create a plan that will achieve this goal. If however a service in the plan is unavailable or erroneous the plan will fail. Motivated by this problem, this paper suggests autonomous re-planning as a means to overcome dynamic problems. Our solution involves automatically recovering from faults and creating a context-dependent alternate plan. We present an architecture that serves as a basis for the central activities autonomous composition, monitoring and fault handling.

Underlying neural alpha frequency patterns associated with intra-hemispheric inhibition during an interhemispheric transfer task.

PubMed

Simon-Dack, Stephanie L; Kraus, Brian; Walter, Zachary; Smith, Shelby; Cadle, Chelsea

2018-05-18

Interhemispheric transfer measured via differences in right- or left-handed motoric responses to lateralized visual stimuli, known as the crossed-uncrossed difference (CUD), is one way of identifying patterns of processing that are vital for understanding the transfer of neural signals. Examination of interhemispheric transfer by means of the CUD is not entirely explained by simple measures of response time. Multiple processes contribute to wide variability observed in CUD reaction times. Prior research has suggested that intra-hemispheric inhibitory processes may be involved in regulation of speed of transfer. Our study examined electroencephalography recordings and time-locked alpha frequency activity while 18 participants responded to lateralized targets during performance of the Poffenberger Paradigm. Our results suggest that there are alpha frequency differences at fronto-central lateral electrodes based on target, hand-of-response, and receiving hemisphere. These findings suggest that early motoric inhibitory mechanisms may help explain the wide range of variability typically seen with the CUD. Copyright © 2018 Elsevier B.V. All rights reserved.

The Role of Mindfulness in Positive Reappraisal

PubMed Central

Garland, Eric; Gaylord, Susan; Park, Jongbae

2009-01-01

Mindfulness meditation is increasingly well known for therapeutic efficacy in a variety of illnesses and conditions, but its mechanism of action is still under debate in scientific circles. In this paper we propose a hypothetical causal model that argues for the role of mindfulness in positive reappraisal coping. Positive reappraisal is a critical component of meaning-based coping that enables individuals to adapt successfully to stressful life events. Mindfulness, as a metacognitive form of awareness, involves the process of decentering, a shifting of cognitive sets that enables alternate appraisals of life events. We review the concept of positive reappraisal in transactional stress and coping theory; then describe research and traditional literature related to mindfulness and cognitive reappraisal, and detail the central role of mindfulness in the reappraisal process. With this understanding, we present a causal model explicating the proposed mechanism. The discussion has implications for clinical practice, suggesting how mindfulness-based integrative medicine interventions can be designed to support adaptive coping processes. PMID:19114262

Creative work. The case of Charles Darwin.

PubMed

Gruber, H E; Wallace, D B

2001-04-01

The evolving systems approach (ESA) addresses the need for direct study of the creative process in recognized creators at work, in contrast to indirect methods, such as those used in psychometric studies. The ESA emerged from H. E. Gruber's prolonged study of Charles Darwin's manuscripts, especially the notebooks he kept after the Beagle voyage. Gruber's interviews with J. Piaget about the latter's creative processes, as well as many doctoral dissertations, also helped shape the authors' approach. Using Gruber's (1974/1981) study of Darwin, the authors describe some facets of creative work identified in the course of their work. Among these are networks of enterprise, ensembles of metaphors, insights, and evolving belief systems. Although the ESA emphasizes cognitive processes, social, affective, and esthetic aspects of the case are not neglected. Each creative case is unique, otherwise the individual would not meet the criterion of originality. Uniqueness does not mean isolation; people who differ must and do work together. The integration of all these facets into a plausible system for each creator remains the authors' central task.

ERP correlates of attentional processing in spider fear: evidence of threat-specific hypervigilance.

PubMed

Venetacci, Rebecca; Johnstone, Amber; Kirkby, Kenneth C; Matthews, Allison

2018-05-01

Attentional bias towards threat can be demonstrated by enhanced processing of threat-related targets and/or greater interference when threat-related distractors are present. These effects are argued to reflect processing within the orienting and executive control networks of the brain respectively. This study investigated behavioural (RT) and electrophysiological correlates of early selective attention and top-down attentional control among females with high (n = 16) or low (n = 16) spider fear (Mean age = 22 years). Participants completed a novel flanker go/nogo task in which a central schematic flower or spider stimulus was flanked by either congruent or incongruent distractors. Participants responded to green stimuli (go trials) and withheld response to yellow stimuli (nogo trials). High fear participants demonstrated significantly shorter reaction times and greater P1 amplitude to spider targets, suggesting specific hypervigilance towards threat-relevant stimuli. In contrast to predictions, there was little evidence for behavioural interference effects or differences in N2 amplitude when distractor stimuli were threat-relevant.

Adiabatic cooling processes in frustrated magnetic systems with pyrochlore structure

NASA Astrophysics Data System (ADS)

Jurčišinová, E.; Jurčišin, M.

2017-11-01

We investigate in detail the process of adiabatic cooling in the framework of the exactly solvable antiferromagnetic spin-1/2 Ising model in the presence of the external magnetic field on an approximate lattice with pyrochlore structure. The behavior of the entropy of the model is studied and exact values of the residual entropies of all ground states are found. The temperature variation of the system under adiabatic (de)magnetization is investigated and the central role of the macroscopically degenerated ground states in cooling processes is explicitly demonstrated. It is shown that the model parameter space of the studied geometrically frustrated system is divided into five disjunct regions with qualitatively different processes of the adiabatic cooling. The effectiveness of the adiabatic (de)magnetization cooling in the studied model is compared to the corresponding processes in paramagnetic salts. It is shown that the processes of the adiabatic cooling in the antiferromagnetic frustrated systems are much more effective especially in nonzero external magnetic fields. It means that the frustrated magnetic materials with pyrochlore structure can be considered as very promising refrigerants mainly in the situations with nonzero final values of the magnetic field.

Model Uncertainty Quantification Methods For Data Assimilation In Partially Observed Multi-Scale Systems

NASA Astrophysics Data System (ADS)

Pathiraja, S. D.; van Leeuwen, P. J.

2017-12-01

Model Uncertainty Quantification remains one of the central challenges of effective Data Assimilation (DA) in complex partially observed non-linear systems. Stochastic parameterization methods have been proposed in recent years as a means of capturing the uncertainty associated with unresolved sub-grid scale processes. Such approaches generally require some knowledge of the true sub-grid scale process or rely on full observations of the larger scale resolved process. We present a methodology for estimating the statistics of sub-grid scale processes using only partial observations of the resolved process. It finds model error realisations over a training period by minimizing their conditional variance, constrained by available observations. Special is that these realisations are binned conditioned on the previous model state during the minimization process, allowing for the recovery of complex error structures. The efficacy of the approach is demonstrated through numerical experiments on the multi-scale Lorenz 96' model. We consider different parameterizations of the model with both small and large time scale separations between slow and fast variables. Results are compared to two existing methods for accounting for model uncertainty in DA and shown to provide improved analyses and forecasts.

Adiabatic cooling processes in frustrated magnetic systems with pyrochlore structure.

PubMed

Jurčišinová, E; Jurčišin, M

2017-11-01

We investigate in detail the process of adiabatic cooling in the framework of the exactly solvable antiferromagnetic spin-1/2 Ising model in the presence of the external magnetic field on an approximate lattice with pyrochlore structure. The behavior of the entropy of the model is studied and exact values of the residual entropies of all ground states are found. The temperature variation of the system under adiabatic (de)magnetization is investigated and the central role of the macroscopically degenerated ground states in cooling processes is explicitly demonstrated. It is shown that the model parameter space of the studied geometrically frustrated system is divided into five disjunct regions with qualitatively different processes of the adiabatic cooling. The effectiveness of the adiabatic (de)magnetization cooling in the studied model is compared to the corresponding processes in paramagnetic salts. It is shown that the processes of the adiabatic cooling in the antiferromagnetic frustrated systems are much more effective especially in nonzero external magnetic fields. It means that the frustrated magnetic materials with pyrochlore structure can be considered as very promising refrigerants mainly in the situations with nonzero final values of the magnetic field.

Computing at DESY — current setup, trends and strategic directions

NASA Astrophysics Data System (ADS)

Ernst, Michael

1998-05-01

Since the HERA experiments H1 and ZEUS started data taking in '92, the computing environment at DESY has changed dramatically. Running a mainframe centred computing for more than 20 years, DESY switched to a heterogeneous, fully distributed computing environment within only about two years in almost every corner where computing has its applications. The computing strategy was highly influenced by the needs of the user community. The collaborations are usually limited by current technology and their ever increasing demands is the driving force for central computing to always move close to the technology edge. While DESY's central computing has a multidecade experience in running Central Data Recording/Central Data Processing for HEP experiments, the most challenging task today is to provide for clear and homogeneous concepts in the desktop area. Given that lowest level commodity hardware draws more and more attention, combined with the financial constraints we are facing already today, we quickly need concepts for integrated support of a versatile device which has the potential to move into basically any computing area in HEP. Though commercial solutions, especially addressing the PC management/support issues, are expected to come to market in the next 2-3 years, we need to provide for suitable solutions now. Buying PC's at DESY currently at a rate of about 30/month will otherwise absorb any available manpower in central computing and still will leave hundreds of unhappy people alone. Though certainly not the only region, the desktop issue is one of the most important one where we need HEP-wide collaboration to a large extent, and right now. Taking into account that there is traditionally no room for R&D at DESY, collaboration, meaning sharing experience and development resources within the HEP community, is a predominant factor for us.

Modeling and characterization of the CEJ for optimization of esthetic implant design.

PubMed

Gallucci, German O; Belser, Urs C; Bernard, Jean-Pierre; Magne, Pascal

2004-02-01

This study evaluated the dimensions and characteristics of the cementoenamel junction (CEJ) of maxillary anterior teeth; the natural CEJ was compared to current implant design and used for design optimization. Standardized digital images of 137 extracted human teeth (45 central incisors, 46 lateral incisors, and 46 canines) were used to measure cervical dimensions, CEJ curvature, and distance from zenith of CEJ to interdental contact on proximal views. The x- and y-coordinates of the CEJ contour were digitized before mathematic processing to allow the representation of a single average curve for buccal, palatal, mesial, and distal surfaces for each tooth type. These measurements were combined to existing data related to dentogingival and "implantomucosal" junction to extrapolate specific biologic landmarks around teeth and implants. Mean cervical dimensions, distance from zenith of CEJ to interdental contact, and CEJ curvature were compared. Cervical dimensions significantly differed, with a more symmetric cervical cross-section for central incisors, slightly more rectangular shape for lateral incisors, and distinctly rectangular shape for canines. CEJ curvature was statistically different between all tooth groups (centrals > laterals > canines); within groups, curvature value was always superior at the mesial aspect compared to distally (3.46 mm vs 3.13 mm for centrals, 2.97 mm vs 2.38 mm for laterals, and 2.55 mm vs 1.60 mm for canines). Tooth-implant biologic width discrepancies ranged from 4.10 to 5.96 mm and were different between all groups of teeth (centrals > laterals > canines); within groups, the discrepancy was always superior at the mesial aspect compared to distally. Current implant design featuring a flat, rotation-symmetric shoulder should be reconsidered in view of natural CEJ contour to improve biologic considerations and related esthetics.

Time-series analysis to observe the impact of a centrally organized educational intervention on the prevention of central-line-associated bloodstream infections in 32 German intensive care units.

PubMed

Hansen, S; Schwab, F; Schneider, S; Sohr, D; Gastmeier, P; Geffers, C

2014-08-01

Prevention measures reduce central-line-associated bloodstream infections (CLABSIs) but are not always implemented. To investigate the effect of a central educational programme in German intensive care units (ICUs) on CLABSI rates. Thirty-two German ICUs with CLABSI rates greater than or equal to the national average were compared with two control groups containing 277 and 67 ICUs. Processes and CLABSI rates were surveyed before, during and two years after the implementation of a year-long intervention programme. Segmented regression analysis of interrupted time series using generalized linear models was performed to estimate the association between the number of CLABSIs per month and time, intervention and other confounders, with the clustering effect within an ICU taken into account. In total, 508 cases of CLABSI were observed over 266,471 central line (CL)-days. At baseline, the pooled mean CLABSI rate was 2.29 per 1000 CL-days, and this decreased significantly to 1.64 per 1000 CL-days in the follow-up period. Compared with baseline, the relative risk for CLABSI was 0.88 [95% confidence interval (CI) 0.70-1.11] for the intervention period and 0.72 (95% CI 0.58-0.88) for the follow-up period. No changes were observed in either control group. Following successful implementation of the programme, ICUs showed a significant decrease in CLABSI rates. Although rates were already decreasing prior to implementation of the intervention, the invitation to participate in the study, and increased general awareness of CLABSI prevention through use of the comprehensive multi-modal training materials may have had a beneficial effect on practice. Copyright © 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.