On-site or off-site treatment of medical waste: a challenge

PubMed Central

2014-01-01

Treating hazardous-infectious medical waste can be carried out on-site or off-site of health-care establishments. Nevertheless, the selection between on-site and off-site locations for treating medical waste sometimes is a controversial subject. Currently in Iran, due to policies of Health Ministry, the hospitals have selected on-site-treating method as the preferred treatment. The objectives of this study were to assess the current condition of on-site medical waste treatment facilities, compare on-site medical waste treatment facilities with off-site systems and find the best location of medical waste treatment. To assess the current on-site facilities, four provinces (and 40 active hospitals) were selected to participate in the survey. For comparison of on-site and off-site facilities (due to non availability of an installed off-site facility) Analytical Hierarchy Process (AHP) was employed. The result indicated that most on-site medical waste treating systems have problems in financing, planning, determining capacity of installations, operation and maintenance. AHP synthesis (with inconsistency ratio of 0.01 < 0.1) revealed that, in total, the off-site treatment of medical waste was in much higher priority than the on-site treatment (64.1% versus 35.9%). According to the results of study it was concluded that the off-site central treatment can be considered as an alternative. An amendment could be made to Iran’s current medical waste regulations to have infectious-hazardous waste sent to a central off-site installation for treatment. To begin and test this plan and also receive the official approval, a central off-site can be put into practice, at least as a pilot in one province. Next, if it was practically successful, it could be expanded to other provinces and cities. PMID:24739145

Variability of the institutional review board process within a national research network.

PubMed

Khan, Muhammad A; Barratt, Michelle S; Krugman, Scott D; Serwint, Janet R; Dumont-Driscoll, Marilyn

2014-06-01

To determine the variability of the institutional review board (IRB) process for a minimal risk multicenter study. Participants included 24 Continuity Research Network (CORNET) sites of the Academic Pediatric Association that participated in a cross-sectional study. Each site obtained individual institutional IRB approval. An anonymous questionnaire went to site investigators about the IRB process at their institution. Twenty-two of 24 sites (92%) responded. Preparation time ranged from 1 to 20 hours, mean of 7.1 hours. Individuals submitting ≤3 IRB applications/year required more time for completion than those submitting >3/year (P < .05). Thirteen of 22 (59%) study sites received approval with "exempt" status, and 6 (27%) approved as "expedited" studies. IRB experiences were highly variable across study sites. These findings indicate that multicenter research projects should anticipate barriers to timely study implementation. Improved IRB standardization or centralization for multicenter clinical studies would facilitate this type of practice-based clinical research.

Impaired neural structure and function contributing to autonomic symptoms in congenital central hypoventilation syndrome.

PubMed

Harper, Ronald M; Kumar, Rajesh; Macey, Paul M; Harper, Rebecca K; Ogren, Jennifer A

2015-01-01

Congenital central hypoventilation syndrome (CCHS) patients show major autonomic alterations in addition to their better-known breathing deficiencies. The processes underlying CCHS, mutations in the PHOX2B gene, target autonomic neuronal development, with frame shift extent contributing to symptom severity. Many autonomic characteristics, such as impaired pupillary constriction and poor temperature regulation, reflect parasympathetic alterations, and can include disturbed alimentary processes, with malabsorption and intestinal motility dyscontrol. The sympathetic nervous system changes can exert life-threatening outcomes, with dysregulation of sympathetic outflow leading to high blood pressure, time-altered and dampened heart rate and breathing responses to challenges, cardiac arrhythmia, profuse sweating, and poor fluid regulation. The central mechanisms contributing to failed autonomic processes are readily apparent from structural and functional magnetic resonance imaging studies, which reveal substantial cortical thinning, tissue injury, and disrupted functional responses in hypothalamic, hippocampal, posterior thalamic, and basal ganglia sites and their descending projections, as well as insular, cingulate, and medial frontal cortices, which influence subcortical autonomic structures. Midbrain structures are also compromised, including the raphe system and its projections to cerebellar and medullary sites, the locus coeruleus, and medullary reflex integrating sites, including the dorsal and ventrolateral medullary nuclei. The damage to rostral autonomic sites overlaps metabolic, affective and cognitive regulatory regions, leading to hormonal disruption, anxiety, depression, behavioral control, and sudden death concerns. The injuries suggest that interventions for mitigating hypoxic exposure and nutrient loss may provide cellular protection, in the same fashion as interventions in other conditions with similar malabsorption, fluid turnover, or hypoxic exposure.

Estimation of PAHs dry deposition and BaP toxic equivalency factors (TEFs) study at Urban, Industry Park and rural sampling sites in central Taiwan, Taichung.

PubMed

Fang, Guor-Cheng; Chang, Kuan-Foo; Lu, Chungsying; Bai, Hsunling

2004-05-01

The concentrations of polycyclic aromatic hydrocarbons (PAHs) in gas phase and particle bound were measured simultaneously at industrial (INDUSTRY), urban (URBAN), and rural areas (RURAL) in Taichung, Taiwan. And the PAH concentrations, size distributions, estimated PAHs dry deposition fluxes and health risk study of PAHs in the ambient air of central Taiwan were discussed in this study. Total PAH concentrations at INDUSTRY, URBAN, and RURAL sampling sites were found to be 1650 +/- 1240, 1220 +/- 520, and 831 +/- 427 ng/m3, respectively. The results indicated that PAH concentrations were higher at INDUSTRY and URBAN sampling sites than the RURAL sampling sites because of the more industrial processes, traffic exhausts and human activities. The estimation dry deposition and size distribution of PAHs were also studied. The results indicated that the estimated dry deposition fluxes of total PAHs were 58.5, 48.8, and 38.6 microg/m2/day at INDUSTRY, URBAN, and RURAL, respectively. The BaP equivalency results indicated that the health risk of gas phase PAHs were higher than the particle phase at three sampling sites of central Taiwan. However, compared with the BaP equivalency results to other studies conducted in factory, this study indicated the health risk of PAHs was acceptable in the ambient air of central Taiwan.

Four Years Later--How Greece, N.Y., Uses Site-Based Management.

ERIC Educational Resources Information Center

Bahrenfuss, Rene M.

1992-01-01

Four years of hard work and training have gone into creating site-based management structures and processes at Greece (New York) Central School District. Each school has management team. All schools are dedicated to meeting district's mission and vision, but how schools accomplish these goals is up to them. Except for overall payroll, all…

CENTRAL PLATEAU REMEDIATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

ROMINE, L.D.

2006-02-01

A systematic approach to closure planning is being implemented at the Hanford Site's Central Plateau to help achieve the goal of closure by the year 2035. The overall objective of Central Plateau remediation is to protect human health and the environment from the significant quantity of contaminated material that resulted from decades of plutonium production in support of the nation's defense. This goal will be achieved either by removing contaminants or placing the residual contaminated materials in a secure configuration that minimizes further migration to the groundwater and reduces the potential for inadvertent intrusion into contaminated sites. The approach tomore » Central Plateau cleanup used three key concepts--closure zones, closure elements, and closure process steps--to create an organized picture of actions required to complete remediation. These actions were merged with logic ties, constraints, and required resources to produce an integrated time-phased schedule and cost profile for Central Plateau closure. Programmatic risks associated with implementation of Central Plateau closure were identified and analyzed. Actions to mitigate the most significant risks are underway while high priority remediation projects continue to make progress.« less

Partially Testing a Process Model for Understanding Victim Responses to an Anticipated Worksite Closure

ERIC Educational Resources Information Center

Blau, Gary

2007-01-01

This study partially tested a recent process model for understanding victim responses to worksite/function closure (W/FC) proposed by Blau [Blau, G. (2006). A process model for understanding victim responses to worksite/function closure. "Human Resource Management Review," 16, 12-28], in a pharmaceutical manufacturing site. Central to the model…

Benefits of a comprehensive quality program for cryopreserved PBMC covering 28 clinical trials sites utilizing an integrated, analytical web-based portal

PubMed Central

Ducar, Constance; Smith, Donna; Pinzon, Cris; Stirewalt, Michael; Cooper, Cristine; McElrath, M. Juliana; Hural, John

2014-01-01

The HIV Vaccine Trials Network (HVTN) is a global network of 28 clinical trial sites dedicated to identifying an effective HIV vaccine. Cryopreservation of high-quality peripheral blood mononuclear cells (PBMC) is critical for the assessment of vaccine-induced cellular immune functions. The HVTN PBMC Quality Management Program is designed to ensure viable PBMC are processed, stored and shipped for clinical trial assays from all HVTN clinical trial sites. The program has evolved by developing and incorporating best practices for laboratory and specimen quality and implementing automated, web-based tools. These tools allow the site-affiliated processing laboratories and the central Laboratory Operations Unit to rapidly collect, analyze and report PBMC quality data. The HVTN PBMC Quality Management Program includes five key components: 1) Laboratory Assessment, 2) PBMC Training and Certification, 3) Internal Quality Control, 4) External Quality Control (EQC), and 5) Assay Specimen Quality Control. Fresh PBMC processing data is uploaded from each clinical site processing laboratory to a central HVTN Statistical and Data Management Center database for access and analysis on a web portal. Samples are thawed at a central laboratory for assay or specimen quality control and sample quality data is uploaded directly to the database by the central laboratory. Four year cumulative data covering 23,477 blood draws reveals an average fresh PBMC yield of 1.45×106 ±0.48 cells per milliliter of useable whole blood. 95% of samples were within the acceptable range for fresh cell yield of 0.8–3.2×106 cells/ml of usable blood. Prior to full implementation of the HVTN PBMC Quality Management Program, the 2007 EQC evaluations from 10 international sites showed a mean day 2 thawed viability of 83.1% and recovery of 67.5%. Since then, four year cumulative data covering 3338 specimens used in immunologic assays shows that 99.88% had acceptable viabilities (>66%) for use in cellular assays (mean, 91.46% ±4.5%), and 96.2% had acceptable recoveries (50%–130%) with a mean of recovery of 85.8% ±19.12% of the originally cryopreserved cells. EQC testing revealed that since August 2009, failed recoveries dropped from 4.1% to 1.6% and failed viabilities dropped from 1.0% to 0.3%. The HVTN PBMC quality program provides for laboratory assessment, training and tools for identifying problems, implementing corrective action and monitoring for improvements. These data support the benefits of implementing a comprehensive, web-based PBMC quality program for large clinical trials networks. PMID:24709391

Landfill site selection using geographic information system and analytical hierarchy process: A case study Al-Hillah Qadhaa, Babylon, Iraq.

PubMed

Chabuk, Ali; Al-Ansari, Nadhir; Hussain, Hussain Musa; Knutsson, Sven; Pusch, Roland

2016-05-01

Al-Hillah Qadhaa is located in the central part of Iraq. It covers an area of 908 km(2) with a total population of 856,804 inhabitants. This Qadhaa is the capital of Babylon Governorate. Presently, no landfill site exists in that area based on scientific site selection criteria. For this reason, an attempt has been carried out to find the best locations for landfills. A total of 15 variables were considered in this process (groundwater depth, rivers, soil types, agricultural land use, land use, elevation, slope, gas pipelines, oil pipelines, power lines, roads, railways, urban centres, villages and archaeological sites) using a geographic information system. In addition, an analytical hierarchy process was used to identify the weight for each variable. Two suitable candidate landfill sites were determined that fulfil the requirements with an area of 9.153 km(2) and 8.204 km(2) These sites can accommodate solid waste till 2030. © The Author(s) 2016.

Feasibility of a Centralized Clinical Trials Coverage Analysis: A Joint Initiative of the American Society of Clinical Oncology and the National Cancer Institute.

PubMed

Szczepanek, Connie M; Hurley, Patricia; Good, Marjorie J; Denicoff, Andrea; Willenberg, Kelly; Dawson, Casey; Kurbegov, Dax

2017-06-01

Clinical trial billing compliance is a challenge that is faced by overburdened clinical trials sites. The requirements place institutions and research sites at increased potential for financial risk. To reduce their risk, sites develop a coverage analysis (CA) before opening each trial. For multisite trials, this translates into system-wide redundancies, inconsistencies, trial delays, and potential costs to sites and patients. These factors exacerbate low accrual rates to cancer clinical trials. ASCO and the National Cancer Institute (NCI) collaborated to address this problem. An ASCO Research Community Forum working group proposed the concept of providing centrally developed CAs to research sites at protocol startup. The group collaborated with NCI and billing compliance experts to hold a symposium for key stakeholders to share knowledge, build skills, provide tools to conduct centralized CAs, and strategize about the next steps. Forty-eight attendees, who represented a range of stakeholders, participated in the symposium. As a result of this initiative, NCI directed the Cancer Trials Support Unit to convene a working group with NCI's National Clinical Trials Network (NCTN) and Community Oncology Research Program (NCORP) to develop tools and processes for generating CAs for their trials. A CA template with core elements was developed and is being adapted in a pilot project across NCTN Group and NCORP Research Bases. Centralized CAs for multisite trials-using standardized tools and templates-are feasible. They have the potential to reduce risk for patients and sites, forecast budget needs, and help decrease trial startup times that impede patient access and accrual to clinical trials.

Collection, processing and dissemination of data for the national solar demonstration program

NASA Technical Reports Server (NTRS)

Day, R. E.; Murphy, L. J.; Smok, J. T.

1978-01-01

A national solar data system developed for the DOE by IBM provides for automatic gathering, conversion, transfer, and analysis of demonstration site data. NASA requirements for this system include providing solar site hardware, engineering, data collection, and analysis. The specific tasks include: (1) solar energy system design/integration; (2) developing a site data acquisition subsystem; (3) developing a central data processing system; (4) operating the test facility at Marshall Space Flight Center; (5) collecting and analyzing data. The systematic analysis and evaluation of the data from the National Solar Data System is reflected in a monthly performance report and a solar energy system performance evaluation report.

A Quantitative Assessment of the Structure and Functions of a Mature Bottomland Hardwood Community: The Iatt Creek Ecosystem Site

Treesearch

Calvin E. Meier; John A. Stanturf; Emile S. Gardiner; Paul B. Hamel; Melvin L. Warren

1999-01-01

We report our efforts, initiated in 1995, to quantify ecological processes and functions in a relatively undisturbed, mature hardwood forest. The 320-ha site is located in central Louisiana on the upper reaches of Iatt Creek, an anastomosing minor stream bottom. The forest is a mature sweetgum (Liquidambar styraciflua L.)-cherrybark oak (

Central Data Processing System (CDPS) user's manual: Solar heating and cooling program

NASA Technical Reports Server (NTRS)

1976-01-01

The software and data base management system required to assess the performance of solar heating and cooling systems installed at multiple sites is presented. The instrumentation data associated with these systems is collected, processed, and presented in a form which supported continuity of performance evaluation across all applications. The CDPS consisted of three major elements: communication interface computer, central data processing computer, and performance evaluation data base. Users of the performance data base were identified, and procedures for operation, and guidelines for software maintenance were outlined. The manual also defined the output capabilities of the CDPS in support of external users of the system.

Assessment of quality and geochemical processes occurring in groundwaters near central air conditioning plant site in Trombay, Maharashtra, India.

PubMed

Tirumalesh, K; Shivanna, K; Sriraman, A K; Tyagi, A K

2010-04-01

This paper summarizes the findings obtained in a monitoring study to understand the sources and processes affecting the quality of shallow and deep groundwater near central air conditioning plant site in Trombay region by making use of physicochemical and biological analyses. All the measured parameters of the groundwaters indicate that the groundwater quality is good and within permissible limits set by (Indian Bureau of Standards 1990). Shallow groundwater is dominantly of Na-HCO(3) type whereas deep groundwater is of Ca-Mg-HCO(3) type. The groundwater chemistry is mainly influenced by dissolution of minerals and base exchange processes. High total dissolved solids in shallow groundwater compared to deeper ones indicate faster circulation of groundwater in deep zone preferably through fissures and fractures whereas groundwater flow is sluggish in shallow zone. The characteristic ionic ratio values and absence of bromide point to the fact that seawater has no influence on groundwater system.

The combined influence of central and peripheral routes in the online persuasion process.

PubMed

SanJosé-Cabezudo, Rebeca; Gutiérrez-Arranz, Ana M; Gutiérrez-Cillán, Jesús

2009-06-01

The elaboration likelihood model (ELM) is one of the most widely used psychological theories in academic literature to account for how advertising information is processed. The current work seeks to overturn one of the basic principles of the ELM and takes account of new variables in the model that help to explain the online persuasion process more clearly. Specifically, we posit that in a context of high-involvement exposure to advertising (e.g., Web pages), central and peripheral processing routes may act together. In a repeated-measures experimental design, 112 participants were exposed to two Web sites of a fictitious travel agency, differing only in their design--serious versus amusing. Findings evidence that a peripheral cue, such as how the Web pages are presented, does prove relevant when attempting to reflect the level of effectiveness. Moreover, if we take account of individuals' motivation when accessing the Internet, whether cognitive or affective, the motivation will impact their response to the Web site design. The work contributes to ELM literature and may help firms to pinpoint those areas and features of Internet advertising that prove most efficient.

Modeling vadose zone processes during land application of food-processing waste water in California's Central Valley.

PubMed

Miller, Gretchen R; Rubin, Yoram; Mayer, K Ulrich; Benito, Pascual H

2008-01-01

Land application of food-processing waste water occurs throughout California's Central Valley and may be degrading local ground water quality, primarily by increasing salinity and nitrogen levels. Natural attenuation is considered a treatment strategy for the waste, which often contains elevated levels of easily degradable organic carbon. Several key biogeochemical processes in the vadose zone alter the characteristics of the waste water before it reaches the ground water table, including microbial degradation, crop nutrient uptake, mineral precipitation, and ion exchange. This study used a process-based, multi-component reactive flow and transport model (MIN3P) to numerically simulate waste water migration in the vadose zone and to estimate its attenuation capacity. To address the high variability in site conditions and waste-stream characteristics, four food-processing industries were coupled with three site scenarios to simulate a range of land application outcomes. The simulations estimated that typically between 30 and 150% of the salt loading to the land surface reaches the ground water, resulting in dissolved solids concentrations up to sixteen times larger than the 500 mg L(-1) water quality objective. Site conditions, namely the ratio of hydraulic conductivity to the application rate, strongly influenced the amount of nitrate reaching the ground water, which ranged from zero to nine times the total loading applied. Rock-water interaction and nitrification explain salt and nitrate concentrations that exceed the levels present in the waste water. While source control remains the only method to prevent ground water degradation from saline wastes, proper site selection and waste application methods can reduce the risk of ground water degradation from nitrogen compounds.

Leveraging constraints and biotelemetry data to pinpoint repetitively used spatial features

USGS Publications Warehouse

Brost, Brian M.; Hooten, Mevin B.; Small, Robert J.

2016-01-01

Satellite telemetry devices collect valuable information concerning the sites visited by animals, including the location of central places like dens, nests, rookeries, or haul‐outs. Existing methods for estimating the location of central places from telemetry data require user‐specified thresholds and ignore common nuances like measurement error. We present a fully model‐based approach for locating central places from telemetry data that accounts for multiple sources of uncertainty and uses all of the available locational data. Our general framework consists of an observation model to account for large telemetry measurement error and animal movement, and a highly flexible mixture model specified using a Dirichlet process to identify the location of central places. We also quantify temporal patterns in central place use by incorporating ancillary behavioral data into the model; however, our framework is also suitable when no such behavioral data exist. We apply the model to a simulated data set as proof of concept. We then illustrate our framework by analyzing an Argos satellite telemetry data set on harbor seals (Phoca vitulina) in the Gulf of Alaska, a species that exhibits fidelity to terrestrial haul‐out sites.

Preliminary design of a solar central receiver for site-specific repowering application (Saguaro Power Plant). Volume II. Preliminary design. Final report, October 1982-September 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, E.R.

1983-09-01

The solar central receiver technology, site, and specific unit for repowering were selected in prior analyses and studies. The objectives of this preliminary design study were to: develop a solar central receiver repowering design for Saguaro that (1) has potential to be economically competitive with fossil fueled plants in near and long term applications, (2) has the greatest chance for completion without further government funding, (3) will further define technical and economic feasibility of a 66 MWe gross size plant that is adequate to meet the requirements for utility and industrial process heat applications, (4) can potentially be constructed andmore » operated within the next five years, and (5) incorporates solar central receiver technology and represents state-of-the-art development. This volume on the preliminary design includes the following sections: executive summary; introduction; changes from advanced conceptual design; preliminary design; system characteristics; economic analysis; and development plan.« less

Benefits of a comprehensive quality program for cryopreserved PBMC covering 28 clinical trials sites utilizing an integrated, analytical web-based portal.

PubMed

Ducar, Constance; Smith, Donna; Pinzon, Cris; Stirewalt, Michael; Cooper, Cristine; McElrath, M Juliana; Hural, John

2014-07-01

The HIV Vaccine Trials Network (HVTN) is a global network of 28 clinical trial sites dedicated to identifying an effective HIV vaccine. Cryopreservation of high-quality peripheral blood mononuclear cells (PBMC) is critical for the assessment of vaccine-induced cellular immune functions. The HVTN PBMC Quality Management Program is designed to ensure that viable PBMC are processed, stored and shipped for clinical trial assays from all HVTN clinical trial sites. The program has evolved by developing and incorporating best practices for laboratory and specimen quality and implementing automated, web-based tools. These tools allow the site-affiliated processing laboratories and the central Laboratory Operations Unit to rapidly collect, analyze and report PBMC quality data. The HVTN PBMC Quality Management Program includes five key components: 1) Laboratory Assessment, 2) PBMC Training and Certification, 3) Internal Quality Control, 4) External Quality Control (EQC), and 5) Assay Specimen Quality Control. Fresh PBMC processing data is uploaded from each clinical site processing laboratory to a central HVTN Statistical and Data Management Center database for access and analysis on a web portal. Samples are thawed at a central laboratory for assay or specimen quality control and sample quality data is uploaded directly to the database by the central laboratory. Four year cumulative data covering 23,477 blood draws reveals an average fresh PBMC yield of 1.45×10(6)±0.48 cells per milliliter of useable whole blood. 95% of samples were within the acceptable range for fresh cell yield of 0.8-3.2×10(6) cells/ml of usable blood. Prior to full implementation of the HVTN PBMC Quality Management Program, the 2007 EQC evaluations from 10 international sites showed a mean day 2 thawed viability of 83.1% and a recovery of 67.5%. Since then, four year cumulative data covering 3338 specimens used in immunologic assays shows that 99.88% had acceptable viabilities (>66%) for use in cellular assays (mean, 91.46% ±4.5%), and 96.2% had acceptable recoveries (50%-130%) with a mean of recovery of 85.8% ±19.12% of the originally cryopreserved cells. EQC testing revealed that since August 2009, failed recoveries dropped from 4.1% to 1.6% and failed viabilities dropped from 1.0% to 0.3%. The HVTN PBMC quality program provides for laboratory assessment, training and tools for identifying problems, implementing corrective action and monitoring for improvements. These data support the benefits of implementing a comprehensive, web-based PBMC quality program for large clinical trials networks. Copyright © 2014 Elsevier B.V. All rights reserved.

Outdoor near-roadway, community and residential pollen, carbon dioxide and particulate matter measurements in the urban core of an agricultural region in central CA

NASA Astrophysics Data System (ADS)

Shendell, Derek G.; Therkorn, Jennifer H.; Yamamoto, Naomichi; Meng, Qingyu; Kelly, Sarah W.; Foster, Christine A.

2012-04-01

We can control asthma through proper clinical and environmental management and education. The U.S. population is growing, urbanizing and aging; seniors of low-to-middle income families are working and living longer. We conducted community-based participatory research in Visalia, Tulare County, California with a prospective, cross-sectional repeated measures design and quantitative and qualitative process; home environment and health-related outcomes data were collected. In this paper, we presented results of the air quality sampling-pollen, carbon dioxide (CO2) and particulate matter (PM) outdoors away from most major sources (agricultural fields, large pollinating trees, etc)-at a community central site close to a mobile line source and participant homes in the cooling season, July, 2009. Weather was hot and dry with light winds; diurnal variation ranged between 65-107 °F (18-42 °C) and 12-76% relative humidity at the study's central site. Co-located active (reference) and passive (PAAS) samplers were used for pollen; passive monitoring for CO2 (Telaire 7001) and active sampling for PM were conducted. Overall, we observed spatial variability in CO2, fine PM (PM2.5), and pollen counts. Weekday and study week average CO2 and PM2.5 concentrations were higher near study homes compared to central site sampling points, but peak measures and overnight/pre-dawn time period averages were elevated at the central site. Pollen counts were typically lower at homes-even if grass, trees, flowers or potted plants were present-compared to the central site closer to and generally downwind from commercial agricultural tree production. Data are new; the nine-county San Joaquin Valley has one pollen count station in the national network, and two of four government outdoor air monitoring stations in the county are in national parks. We suggest-given poor air quality in large part due to PM-adding routine pollen counts to regional/state agency air monitoring sites and more CO2 and PM monitoring.

HANFORD SITE CENTRAL PLATEAU CLEANUP COMPLETION STRATEGY

DOE Office of Scientific and Technical Information (OSTI.GOV)

BERGMAN TB

2011-01-14

Cleanup of the Hanford Site is a complex and challenging undertaking. The U.S. Department of Energy (DOE) has developed a comprehensive vision for completing Hanford's cleanup mission including transition to post-cleanup activities. This vision includes 3 principle components of cleanup: the {approx}200 square miles ofland adjacent to the Columbia River, known as the River Corridor; the 75 square miles of land in the center of the Hanford Site, where the majority of the reprocessing and waste management activities have occurred, known as the Central Plateau; and the stored reprocessing wastes in the Central Plateau, the Tank Wastes. Cleanup of themore » River Corridor is well underway and is progressing towards completion of most cleanup actions by 2015. Tank waste cleanup is progressing on a longer schedule due to the complexity of the mission, with construction of the largest nuclear construction project in the United States, the Waste Treatment Plant, over 50% complete. With the progress on the River Corridor and Tank Waste, it is time to place increased emphasis on moving forward with cleanup of the Central Plateau. Cleanup of the Hanford Site has been proceeding under a framework defmed in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). In early 2009, the DOE, the State of Washington Department of Ecology, and the U.S. Environmental Protection Agency signed an Agreement in Principle in which the parties recognized the need to develop a more comprehensive strategy for cleanup of the Central Plateau. DOE agreed to develop a Central Plateau Cleanup Completion Strategy as a starting point for discussions. This DOE Strategy was the basis for negotiations between the Parties, discussions with the State of Oregon, the Hanford Advisory Board, and other Stakeholder groups (including open public meetings), and consultation with the Tribal Nations. The change packages to incorporate the Central Plateau Cleanup Completion Strategy were signed by the Parties on October 26,2010, and are now in the process of being implemented.« less

Movement and fate of atrazine and bromide in central Kansas croplands

USGS Publications Warehouse

Sophocleous, M.; Townsend, M.A.; Whittemore, Donald O.

1990-01-01

Two flooding experiments were conducted at two sites with different soils to study the transport and fate of the commonly used herbicide atrazine and inorganic chemicals in the Great Bend Prairie croplands of south-central Kansas. The instantaneous profile method supplemented by the use of an organic (atrazine) and an inorganic (bromide) tracer chemical was used to characterize in situ the hydraulic and chemical properties of the appropriately instrumented field sites. Atrazine readily degraded to hydroxyatrazine and biodegradation by-products and was not detected deeper in the soil profile and underlying shallow aquifer. The classical processes of chemical movement based on porous media-equilibrium-diffuse flow did not fit the data well at either site. Incompletely mixed, slug flow appeared to predominate at one of the sites and preferential flow at the other. The slug movement caused 'piston-type' displacement of more saline solutions in the soil profile to the shallow water table. Recommendations for conducting related field studies based on our sampling experience are given. ?? 1990.

Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors

PubMed Central

Fuller, Christina H.; Brugge, Doug; Williams, Paige; Mittleman, Murray; Durant, John L.; Spengler, John D.

2012-01-01

Ultrafine particles (UFP; aerodynamic diameter < 0.1 micrometers) are a ubiquitous exposure in the urban environment and are elevated near highways. Most epidemiological studies of UFP health effects use central site monitoring data, which may misclassify exposure. Our aims were to: (1) examine the relationship between distant and proximate monitoring sites and their ability to predict hourly UFP concentration measured at residences in an urban community with a major interstate highway and; (2) determine if meteorology and proximity to traffic improve explanatory power. Short-term (1 – 3 weeks) residential monitoring of UFP concentration was conducted at 18 homes. Long-term monitoring was conducted at two near-highway monitoring sites and a central site. We created models of outdoor residential UFP concentration based on concentrations at the near-highway site, at the central site, at both sites together and without fixed sites. UFP concentration at residential sites was more highly correlated with those at a near-highway site than a central site. In regression models of each site alone, a 10% increase in UFP concentration at a near-highway site was associated with a 6% (95% CI: 6%, 7%) increase at residences while a 10% increase in UFP concentration at the central site was associated with a 3% (95% CI: 2%, 3%) increase at residences. A model including both sites showed minimal change in the magnitude of the association between the near-highway site and the residences, but the estimated association with UFP concentration at the central site was substantially attenuated. These associations remained after adjustment for other significant predictors of residential UFP concentration, including distance from highway, wind speed, wind direction, highway traffic volume and precipitation. The use of a central site as an estimate of personal exposure for populations near local emissions of traffic-related air pollutants may result in exposure misclassification. PMID:23645993

Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors.

PubMed

Fuller, Christina H; Brugge, Doug; Williams, Paige; Mittleman, Murray; Durant, John L; Spengler, John D

2012-09-01

Ultrafine particles (UFP; aerodynamic diameter < 0.1 micrometers) are a ubiquitous exposure in the urban environment and are elevated near highways. Most epidemiological studies of UFP health effects use central site monitoring data, which may misclassify exposure. Our aims were to: (1) examine the relationship between distant and proximate monitoring sites and their ability to predict hourly UFP concentration measured at residences in an urban community with a major interstate highway and; (2) determine if meteorology and proximity to traffic improve explanatory power. Short-term (1 - 3 weeks) residential monitoring of UFP concentration was conducted at 18 homes. Long-term monitoring was conducted at two near-highway monitoring sites and a central site. We created models of outdoor residential UFP concentration based on concentrations at the near-highway site, at the central site, at both sites together and without fixed sites. UFP concentration at residential sites was more highly correlated with those at a near-highway site than a central site. In regression models of each site alone, a 10% increase in UFP concentration at a near-highway site was associated with a 6% (95% CI: 6%, 7%) increase at residences while a 10% increase in UFP concentration at the central site was associated with a 3% (95% CI: 2%, 3%) increase at residences. A model including both sites showed minimal change in the magnitude of the association between the near-highway site and the residences, but the estimated association with UFP concentration at the central site was substantially attenuated. These associations remained after adjustment for other significant predictors of residential UFP concentration, including distance from highway, wind speed, wind direction, highway traffic volume and precipitation. The use of a central site as an estimate of personal exposure for populations near local emissions of traffic-related air pollutants may result in exposure misclassification.

A multi-criteria assessment of scenarios on thermal processing of infectious hospital wastes: A case study for Central Macedonia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karagiannidis, A.; Papageorgiou, A., E-mail: apapa@auth.g; Perkoulidis, G.

In Greece more than 14,000 tonnes of infectious hospital waste are produced yearly; a significant part of it is still mismanaged. Only one off-site licensed incineration facility for hospital wastes is in operation, with the remaining of the market covered by various hydroclave and autoclave units, whereas numerous problems are still generally encountered regarding waste segregation, collection, transportation and management, as well as often excessive entailed costs. Everyday practices still include dumping the majority of solid hospital waste into household disposal sites and landfills after sterilization, still largely without any preceding recycling and separation steps. Discussed in the present papermore » are the implemented and future treatment practices of infectious hospital wastes in Central Macedonia; produced quantities are reviewed, actual treatment costs are addressed critically, whereas the overall situation in Greece is discussed. Moreover, thermal treatment processes that could be applied for the treatment of infectious hospital wastes in the region are assessed via the multi-criteria decision method Analytic Hierarchy Process. Furthermore, a sensitivity analysis was performed and the analysis demonstrated that a centralized autoclave or hydroclave plant near Thessaloniki is the best performing option, depending however on the selection and weighing of criteria of the multi-criteria process. Moreover the study found that a common treatment option for the treatment of all infectious hospital wastes produced in the Region of Central Macedonia, could offer cost and environmental benefits. In general the multi-criteria decision method, as well as the conclusions and remarks of this study can be used as a basis for future planning and anticipation of the needs for investments in the area of medical waste management.« less

Use of linkage mapping and centrality analysis across habitat gradients to conserve connectivity of gray wolf populations in western North America.

PubMed

Carroll, Carlos; McRae, Brad H; Brookes, Allen

2012-02-01

Centrality metrics evaluate paths between all possible pairwise combinations of sites on a landscape to rank the contribution of each site to facilitating ecological flows across the network of sites. Computational advances now allow application of centrality metrics to landscapes represented as continuous gradients of habitat quality. This avoids the binary classification of landscapes into patch and matrix required by patch-based graph analyses of connectivity. It also avoids the focus on delineating paths between individual pairs of core areas characteristic of most corridor- or linkage-mapping methods of connectivity analysis. Conservation of regional habitat connectivity has the potential to facilitate recovery of the gray wolf (Canis lupus), a species currently recolonizing portions of its historic range in the western United States. We applied 3 contrasting linkage-mapping methods (shortest path, current flow, and minimum-cost-maximum-flow) to spatial data representing wolf habitat to analyze connectivity between wolf populations in central Idaho and Yellowstone National Park (Wyoming). We then applied 3 analogous betweenness centrality metrics to analyze connectivity of wolf habitat throughout the northwestern United States and southwestern Canada to determine where it might be possible to facilitate range expansion and interpopulation dispersal. We developed software to facilitate application of centrality metrics. Shortest-path betweenness centrality identified a minimal network of linkages analogous to those identified by least-cost-path corridor mapping. Current flow and minimum-cost-maximum-flow betweenness centrality identified diffuse networks that included alternative linkages, which will allow greater flexibility in planning. Minimum-cost-maximum-flow betweenness centrality, by integrating both land cost and habitat capacity, allows connectivity to be considered within planning processes that seek to maximize species protection at minimum cost. Centrality analysis is relevant to conservation and landscape genetics at a range of spatial extents, but it may be most broadly applicable within single- and multispecies planning efforts to conserve regional habitat connectivity. ©2011 Society for Conservation Biology.

Canada's Deep Geological Repository for Used Nuclear Fuel - Geo-scientific Site Evaluation Process - 13117

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blyth, Alec; Ben Belfadhel, Mahrez; Hirschorn, Sarah

2013-07-01

The Nuclear Waste Management Organization (NWMO) is responsible for implementing Adaptive Phased Management (APM), the approach selected by the Government of Canada for long-term management of used nuclear fuel generated by Canadian nuclear reactors. The ultimate objective of APM is the centralized containment and isolation of Canada's used nuclear fuel in a Deep Geological Repository in a suitable rock formation at a depth of approximately 500 meters (m) (1,640 feet [ft]). In May 2010, the NWMO published a nine-step site selection process that serves as the road map to decision-making on the location for the deep geological repository. The safetymore » and appropriateness of any potential site will be assessed against a number of factors, both technical and social in nature. The selected site will be one that can be demonstrated to be able to safely contain and isolate used nuclear fuel, protecting humans and the environment over the very long term. The geo-scientific suitability of potential candidate sites will be assessed in a stepwise manner following a progressive and thorough site evaluation process that addresses a series of geo-scientific factors revolving around five safety functions. The geo-scientific site evaluation process includes: Initial Screenings; Preliminary Assessments; and Detailed Site Evaluations. As of November 2012, 22 communities have entered the site selection process (three in northern Saskatchewan and 18 in northwestern and southwestern Ontario). (authors)« less

Tree-ring records of near-Younger Dryas time in central North America - Preliminary results from the Lincoln quarry site, central Illinois, USA

USGS Publications Warehouse

Panyushkina, Irina P.; Leavitt, Steven W.; Wiedenhoeft, A.; Noggle, S.; Curry, B.; Grimm, E.

2004-01-01

The abrupt millennial-scale changes associated with the Younger Dryas (YD) event ("chronozone") near the dawn of the Holocene are at least hemispheric, if not global, in extent. Evidence for the YD cold excursion is abundant in Europe but fairly meager in central North America. We are engaged in an investigation of high-resolution environmental changes in mid-North America over several millennia (about 10,000 to 14,000 BP) during the Late Glacial-Early Holocene transition, including the YD interval. Several sites containing logs or stumps have been identified and we are in the process of initial sampling or re-sampling them for this project. Here, we report on a site in central Illinois containing a deposit of logs initially thought to be of YD age preserved in alluvial sands. The assemblage of wood represents hardwood (angiosperm) trees, and the ring-width characteristics are favorable to developing formal tree-ring chronologies. However, 4 new radiocarbon dates indicate deposition of wood may have taken place over at least 8000 14C yr (6000-14,000 BP). This complicates the effort to develop a single floating chronology of several hundred years at this site, but it may provide wood from a restricted region over a long period of time from which to develop a sequence of floating chronologies, the timing of deposition and preservation of which could be related to paleoclimatic events and conditions.

Membrane contact sites, ancient and central hubs of cellular lipid logistics.

PubMed

Jain, Amrita; Holthuis, Joost C M

2017-09-01

Membrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. Copyright © 2017. Published by Elsevier B.V.

Negative Emotion Weakens the Degree of Self-Reference Effect: Evidence from ERPs

PubMed Central

Fan, Wei; Zhong, Yiping; Li, Jin; Yang, Zilu; Zhan, Youlong; Cai, Ronghua; Fu, Xiaolan

2016-01-01

We investigated the influence of negative emotion on the degree of self-reference effect using event-related potentials (ERPs). We presented emotional pictures and self-referential stimuli (stimuli that accelerate and improve processing and improve memory of information related to an individual’s self-concept) in sequence. Participants judged the color of the target stimulus (self-referential stimuli). ERP results showed that the target stimuli elicited larger P2 amplitudes under neutral conditions than under negative emotional conditions. Under neutral conditions, N2 amplitudes for highly self-relevant names (target stimulus) were smaller than those for any other names. Under negative emotional conditions, highly and moderately self-referential stimuli activated smaller N2 amplitudes. P3 amplitudes activated by self-referential processing under negative emotional conditions were smaller than neutral conditions. In the left and central sites, highly self-relevant names activated larger P3 amplitudes than any other names. But in the central sites, moderately self-relevant names activated larger P3 amplitudes than non-self-relevant names. The findings indicate that negative emotional processing could weaken the degree of self-reference effect. PMID:27733836

Reloading Continuous GPS in Northwest Mexico

NASA Astrophysics Data System (ADS)

Gonzalez-Garcia, J. J.; Suarez-Vidal, F.; Gonzalez-Ortega, J. A.

2007-05-01

For more than 10 years we try to follow the steps of the Southern California Integrated GPS Network (SCIGN) and the Plate Boundary Observatory (PBO) in USA, this gives us the opportunity to be in position to contribute to develop a modern GPS Network in Mexico. During 1998 and 2001, three stations were deployed in Northwest Mexico in concert with the development of SCIGN: SPMX in north central Baja California state at the National Astronomical Observatory, UNAM in the Sierra San Pedro Martir; CORX in Isla Coronados Sur, offshore San Diego, Ca./Tijuana, Mexico and GUAX in Guadalupe island 150 miles offshore Baja California peninsula, which provide a unique site on the Pacific plate in the Northamerica/Pacific boundary zone in Las Californias. The former IGS station in CICESE, Ensenada, CICE installed in 1995, was replaced by CIC1 in 1999. In 2004 and 2005 with partial support from SCIGN and UNAVCO to University of Arizona a volunteer team from UNAVCO, Caltech, U.S. Geological Survey, Universidad de la Sierra at Moctezuma Sonora and CICESE built two new shallow-braced GPS sites in northwest Mexico. The first site USMX is located at east-central Sonora and the second YESX is located high in the Sierra Madre Occidental at Yecora near the southern border of Sonora and Chihuahua. All data is openly available at SOPAC and/or UNAVCO. The existing information has been valuable to resolve the "total" plate motion between the Pacific plate (GUAX) and the Northamerica plate (USMX and YESX) in the north- central Gulf of California. Since the last year we have the capability of GPS data processing using GAMIT/GLOBK, and after gain some practice with survey mode data processing we can convert us in a GPS processing center in Mexico. Currently only 2 sites are operational: CIC1 and USMX. With new energy we are ready to contribute to the establishment of a modern GPS network in Mexico for science, hazard monitoring and infrastructure.

Developmental Changes in Infants' Processing of Happy and Angry Facial Expressions: A Neurobehavioral Study

ERIC Educational Resources Information Center

Grossmann, Tobias; Striano, Tricia; Friederici, Angela D.

2007-01-01

Event-related brain potentials were measured in 7- and 12-month-old infants to examine the development of processing happy and angry facial expressions. In 7-month-olds a larger negativity to happy faces was observed at frontal, central, temporal and parietal sites (Experiment 1), whereas 12-month-olds showed a larger negativity to angry faces at…

Support for Astronaut's View of Mexican/ Central American Fires and on-Line Earth Observations Training Manual

NASA Technical Reports Server (NTRS)

Kaminski, Charles F., Jr.

1999-01-01

A small project to compile remote sensing and in-site data to review the processes leading to the May 1998 Mexican/Central American fires was undertaken. A web page based on this project was assembled. The second project initiated involved an interactive and on-line program that will replace the paper version of the Earth Observations Preflight Training Manual. Technical support was provided to Prof. Marvin Glasser as needed.

Centralized operations and maintenance planning at the Atacama Large Millimeter/submillimeter Array (ALMA)

NASA Astrophysics Data System (ADS)

Lopez, Bernhard; Whyborn, Nicholas D.; Guniat, Serge; Hernandez, Octavio; Gairing, Stefan

2016-07-01

The Atacama Large Millimeter/submillimeter Array (ALMA) is a joint project between astronomical organizations in Europe, North America, and East Asia, in collaboration with the Republic of Chile. ALMA consists of 54 twelve-meter antennas and 12 seven-meter antennas operating as an aperture synthesis array in the (sub)millimeter wavelength range. Since the inauguration of the observatory back in March 2013 there has been a continuous effort to establish solid operations processes for effective and efficient management of technical and administrative tasks on site. Here a key aspect had been the centralized maintenance and operations planning: input is collected from science stakeholders, the computerized maintenance management system (CMMS) and from the technical teams spread around the world, then this information is analyzed and consolidated based on the established maintenance strategy, the observatory long-term plan and the short-term priorities definitions. This paper presents the high-level process that has been developed for the planning and scheduling of planned- and unplanned maintenance tasks, and for site operations like the telescope array reconfiguration campaigns. We focus on the centralized planning approach by presenting its genesis, its current implementation for the observatory operations including related planning products, and we explore the necessary next steps in order to fully achieve a comprehensive centralized planning approach for ALMA in steady-state operations.

System integration of marketable subsystems. [for residential solar heating and cooling

NASA Technical Reports Server (NTRS)

1979-01-01

Progress is reported in the following areas: systems integration of marketable subsystems; development, design, and building of site data acquisition subsystems; development and operation of the central data processing system; operation of the MSFC Solar Test Facility; and systems analysis.

Performance on Tests of Central Auditory Processing by Individuals Exposed to High-Intensity Blasts

DTIC Science & Technology

2012-07-01

percent (gap detected on at least four of the six presentations), with all longer durations receiving a score greater than 50 percent. Binaural ...Processing and Sound Localization Temporal precision of neural firing is also involved in binaural processing and localization of sound in space. The...Masking Level Difference (MLD) test evaluates the integrity of the earliest sites of binaural comparison and sensitivity to interaural phase in the

THE INTEGRATION OF A PROPOSED ZONE CLOSURE APPROACH FOR THE PLUTONIUM FINISHING PLANT (PFP) DECOMMISSIONING & THE PFP ZONE HANFORD SITE WASHINGTON

DOE Office of Scientific and Technical Information (OSTI.GOV)

HOPKINS, A.M.

2005-02-23

The Plutonium Finishing Plant (PFP) and associated processing facilities are located in the 200 area of the Hanford Site in Eastern Washington. This area is part of what is now called the Central Plateau. In order to achieve closure of the contaminated facilities and waste sites at Hanford on the Central Plateau (CP), a geographic re-districting of the area into zones has been proposed in the recently published Plan for Central Plateau Closure. One of the 22 zones proposed in the Central Plateau encompasses the PFP and ancillary facilities. Approximately eighty six buildings are included in the PFP Zone. Thismore » paper addresses the approach for the closure of the PFP Zone within the Central Plateau. The PFP complex of buildings forms the bulk of the structures in the PFP Zone. For closure of the above-grade portion of structures within the PFP complex, the approach is to remove them to a state called ''slab-on-grade'' per the criteria contained in PFP End Point Criteria document and as documented in action memoranda. For below-grade portions of the structures (such as below-grade rooms, pipe trenches and underground ducts), the approach is to remove as much residual contamination as practicable and to fill the void spaces with clean fill material such as sand, grout, or controlled density fill. This approach will be modified as planning for the waste sites progresses to ensure that the actions of the PFP decommissioning projects do not negatively impact future planned actions under the CERCLA. Cribs, settling tanks, septic tanks and other miscellaneous below-grade void spaces will either be cleaned to the extent practicable and filled or will be covered with an environmental barrier as determined by further studies and CERCLA decision documents. Currently, between two and five environmental barriers are proposed to be placed over waste sites and remaining building slabs in the PFP Zone.« less

The Microcomputer in the Administrative Office.

ERIC Educational Resources Information Center

Huntington, Fred

1983-01-01

Discusses microcomputer uses for administrative computing in education at site level and central office and recommends that administrators start with a word processing program for time management, an electronic spreadsheet for financial accounting, a database management system for inventories, and self-written programs to alleviate paper…

Mars Surface Systems Common Capabilities and Challenges for Human Missions

NASA Technical Reports Server (NTRS)

Toups, Larry; Hoffman, Stephen J.

2016-01-01

This paper describes the current status of common systems and operations as they are applied to actual locations on Mars that are representative of Exploration Zones (EZ) - NASA's term for candidate locations where humans could land, live and work on the Martian surface. Given NASA's current concepts for human missions to Mars, an EZ is a collection of Regions of Interest (ROIs) located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. An EZ also contains a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. The Evolvable Mars Campaign (EMC), a description of NASA's current approach to these human Mars missions, assumes that a single EZ will be identified within which NASA will establish a substantial and durable surface infrastructure that will be used by multiple human crews. The process of identifying and eventually selecting this single EZ will likely take many years to finalized. Because of this extended EZ selection process it becomes important to evaluate the current suite of surface systems and operations being evaluated for the EMC as they are likely to perform at a variety of proposed EZ locations and for the types of operations - both scientific and development - that are proposed for these candidate EZs. It is also important to evaluate proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. Four locations identified in the Mars Exploration Program Analysis Group (MEPAG)'s Human Exploration of Mars Science Analysis Group (HEM-SAG) report are used in this paper as representative of candidate EZs that will emerge from the selection process that NASA has initiated. A field station site plan is developed for each of these four HEM-SAG sites. Because of the difficulty in getting equipment and supplies to the surface of Mars, specific assessments have been conducted to identify those systems and processes that can perform in multiple, sometimes completely unrelated, situations. Examples of common systems that are assessed at all of these sites include: (a) habitation and associated logistics storage systems, (b) a centralized power plant capable of supplying power to a geographically distributed (but within the central habitation zone) set of systems, (c) mobility systems that can be used to off-load and move payloads to specific locations at the central field station location that could also be used to traverse long distances to reach some of the more remote ROIs and (d) robotic systems that can support various activities (such as system set up and maintenance) at the field station that could also be used to explore scientific ROIs and used to support site-specific ISRU (In Situ Resource Utilization) production activities.

MX Siting Investigation. Geotechnical Evaluation Conterminous United States. Volume I. Coarse Screening.

DTIC Science & Technology

1977-06-01

the screening process, and the number of unit siting regions of 5000 nm 2 contained in each. The highest ranked suitable areas occur in the Basin and...SUITABLE AND POTENTIALLY SUITABLE AREA............23 3.4.1 GENERAL....................23 3.4.2 BASIN AND RANGE PROVINCE. ........... 23 13.4.3 GREAT...Approximately 70 percent of total suitable area occurs in the Basin and Range, Great Plains, and Central Lowlands physiographic provinces of the western and

AmeriFlux CA-NS6 UCI-1989 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS6 UCI-1989 burn site. Site Description - The UCI-1989 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS2 UCI-1930 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS2 UCI-1930 burn site. Site Description - The UCI-1930 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS3 UCI-1964 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS3 UCI-1964 burn site. Site Description - The UCI-1964 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS7 UCI-1998 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS7 UCI-1998 burn site. Site Description - The UCI-1998 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS8 UCI-2003 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS8 UCI-2003 burn site. Site Description - The UCI-2003 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS5 UCI-1981 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS5 UCI-1981 burn site. Site Description - The UCI-1981 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS4 UCI-1964 burn site wet

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS4 UCI-1964 burn site wet. Site Description - The UCI-1964 wet site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

AmeriFlux CA-NS1 UCI-1850 burn site

DOE Data Explorer

Goulden, Mike [University of California - Irvine

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site CA-NS1 UCI-1850 burn site. Site Description - The UCI-1850 site is located in a continental boreal forest, dominated by black spruce trees, within the BOREAS northern study area in central Manitoba, Canada. The site is a member of a chronological series of sites that are representative secondary succession growth stages after large stand replacement fires. Black spruce trees undergo a slow growth process enabling the accurate determination of the chronosequence of stand age disturbance. Additionally, boreal forests make up approximately 25% of forest ecosystems on earth. With both of these in mind, the UCI sites provide an excellent location to study the CO2 exchange between the atmosphere and boreal forest ecosystems as a function of sequential wildfires.

Water-Level Reconstruction and its Implications for Late Pleistocene Paleontological Site Formation in Hoyo Negro, a Submerged Subterranean Pit in Quintana Roo, Mexico

NASA Astrophysics Data System (ADS)

Rissolo, D.; Reinhardt, E. G.; Collins, S.; Kovacs, S. E.; Beddows, P. A.; Chatters, J. C.; Nava Blank, A.; Luna Erreguerena, P.

2014-12-01

A massive pit deep within the now submerged cave system of Sac Actun, located along the central east coast of the Yucatan Peninsula, contains a diverse fossil assemblage of extinct megafauna as well as a nearly complete human skeleton. The inundated site of Hoyo Negro presents a unique and promising opportunity for interdisciplinary Paleoamerican and paleoenvironmental research in the region. Investigations have thus far revealed a range of associated features and deposits which make possible a multi-proxy approach to identifying and reconstructing the natural and cultural processes that have formed and transformed the site over millennia. Understanding water-level fluctuations (both related to, and independent from, eustatic sea level changes), with respect to cave morphology is central to understanding the movement of humans and animals into and through the cave system. Recent and ongoing studies involve absolute dating of human, faunal, macrobotanical, and geological samples; taphonomic analyses; and a characterization of site hydrogeology and sedimentological facies, including microfossil assemblages and calcite raft deposits.

Operational Procedures for Collecting Water-Quality Samples at Monitoring Sites on Maple Creek Near Nickerson and the Platte River at Louisville, Eastern Nebraska

USGS Publications Warehouse

Johnson, Steven M.; Swanson, Robert B.

1994-01-01

Prototype stream-monitoring sites were operated during part of 1992 in the Central Nebraska Basins (CNBR) and three other study areas of the National Water-Quality Assessment (NAWQ) Program of the U.S. Geological Survey. Results from the prototype project provide information needed to operate a net- work of intensive fixed station stream-monitoring sites. This report evaluates operating procedures for two NAWQA prototype sites at Maple Creek near Nickerson and the Platte River at Louisville, eastern Nebraska. Each site was sampled intensively in the spring and late summer 1992, with less intensive sampling in midsummer. In addition, multiple samples were collected during two high- flow periods at the Maple Creek site--one early and the other late in the growing season. Water-samples analyses included determination of pesticides, nutrients, major ions, suspended sediment, and measurements of physical properties. Equipment and protocols for the water-quality sampling procedures were evaluated. Operation of the prototype stream- monitoring sites included development and comparison of onsite and laboratory sample-processing proce- dures. Onsite processing was labor intensive but allowed for immediate preservation of all sampled constituents. Laboratory processing required less field labor and decreased the risk of contamination, but allowed for no immediate preservation of the samples.

Horizontal crustal motion in the central and eastern Mediterranean inferred from Satellite Laser Ranging measurements

NASA Technical Reports Server (NTRS)

Smith, David E.; Kolenkiewicz, Ron; Robbins, John W.; Dunn, Peter J.; Torrence, Mark H.

1994-01-01

Four campaigns to acquire Satellite Laser Ranging (SLR) measurements at sites in the Mediterranean region have been completed. These measurements to the LAGEOS satellite, made largely by mobile systems, cover a time span beginning in November 1985 and ending in June 1993. The range data from 18 sites in the central and eastern Mediterranean have been simultaneously analyzed with data acquired by the remainder of the global laser tracking network. Estimates of horizontal motion were placed into a regional, northern Europe-fixed, kinematic reference frame. Uncertainties are on the order of 5 mm/yr for sites having at least four occupations by mobile systems and approach 1 mm/yr for permanently located sites with long histories of tracking. The resulting relative motion between sites in the Aegean exhibit characteristics of broadly distributed pattern of radial extension, but at rates that are about 50% larger than those implied from studies of seismic strain rates based on seismicity of magnitude 6 or greater or across the region. The motion estimated for sites in Turkey exhibit velocity components associated with the westward motion of the Anatolian Block relative to Eurasia. These results provide a present-day 'snapshot' of ongoing deformational processes as experienced by the locations occupied by SLR systems.

Effects of peat fires on the characteristics of humic acid extracted from peat soil in Central Kalimantan, Indonesia.

PubMed

Yustiawati; Kihara, Yusuke; Sazawa, Kazuto; Kuramitz, Hideki; Kurasaki, Masaaki; Saito, Takeshi; Hosokawa, Toshiyuki; Syawal, M Suhaemi; Wulandari, Linda; Hendri I; Tanaka, Shunitz

2015-02-01

When peat forest fires happen, it leads to burn soil and also humic acids as a dominant organic matter contained in peat soil as well as the forest. The structure and properties of humic acids vary depending on their origin and environment, therefore the transformation of humic acid is also diverse. The impacts of the peat fires on peat soil from Central Kalimantan, Indonesia were investigated through the characterization of humic acids, extracted from soil in burnt and unburnt sites. The characterization of humic acids was performed by elemental composition, functional groups, molecular weight by HPSEC, pyrolysate compounds by pyrolysis-GC/MS, fluorescence spectrum by 3DEEM spectrofluorometer, and thermogravimetry. The elemental composition of each humic substance indicated that the value of H/C and O/C of humic acids from burnt sites were lower than that from unburnt sites. The molecular weight of humic acids from burnt sites was also lower than that from unburnt sites. Pyrolysate compounds of humic acids from unburnt sites differed from those of humic acids from burnt soil. The heating experiment showed that burning process caused the significant change in the properties of humic acids such as increasing the aromaticity and decreasing the molecular weight.

Two-generation analysis of pollen flow across a landscape. V. A stepwise approach for extracting factors contributing to pollen structure.

Treesearch

R. J. Dyer; R. D. Westfall; V. L. Sork; P. E. Smouse

2004-01-01

Patterns of pollen dispersal are central to both the ecology and evolution of plant populations. However, the mechanisms controlling either the dispersal process itself or our estimation of that process may be influenced by site-specific factors such as local forest structure and nonuniform adult genetic structure. Here, we present an extension of the AMOVA model...

Teachers' Experiences with the Data-Driven Decision Making Process in Increasing Students' Reading Achievement in a Title I Elementary Public School

ERIC Educational Resources Information Center

Atkinson, Linton

2015-01-01

This paper is a research dissertation based on a qualitative case study conducted on Teachers' Experiences within a Data-Driven Decision Making (DDDM) process. The study site was a Title I elementary school in a large school district in Central Florida. Background information is given in relation to the need for research that was conducted on the…

Electronic Resources Evaluation Central: Using Off-the-Shelf Software, Web 2.0 Tools, and LibGuides to Manage an Electronic Resources Evaluation Process

ERIC Educational Resources Information Center

England, Lenore; Fu, Li

2011-01-01

A critical part of electronic resources management, the electronic resources evaluation process is multi-faceted and includes a seemingly endless range of resources and tools involving numerous library staff. A solution is to build a Web site to bring all of the components together that can be implemented quickly and result in an organizational…

The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive.

PubMed

Goldman-Rakic, P S

1996-10-29

The functional architecture of prefrontal cortex is central to our understanding of human mentation and cognitive prowess. This region of the brain is often treated as an undifferentiated structure, on the one hand, or as a mosaic of psychological faculties, on the other. This paper focuses on the working memory processor as a specialization of prefrontal cortex and argues that the different areas within prefrontal cortex represent iterations of this function for different information domains, including spatial cognition, object cognition and additionally, in humans, semantic processing. According to this parallel processing architecture, the 'central executive' could be considered an emergent property of multiple domain-specific processors operating interactively. These processors are specializations of different prefrontal cortical areas, each interconnected both with the domain-relevant long-term storage sites in posterior regions of the cortex and with appropriate output pathways.

Multicenter Cell Processing for Cardiovascular Regenerative Medicine Applications - The Cardiovascular Cell Therapy Research Network (CCTRN) Experience

PubMed Central

Gee, Adrian P.; Richman, Sara; Durett, April; McKenna, David; Traverse, Jay; Henry, Timothy; Fisk, Diann; Pepine, Carl; Bloom, Jeannette; Willerson, James; Prater, Karen; Zhao, David; Koç, Jane Reese; Ellis, Steven; Taylor, Doris; Cogle, Christopher; Moyé, Lemuel; Simari, Robert; Skarlatos, Sonia

2013-01-01

Background Aims Multi-center cellular therapy clinical trials require the establishment and implementation of standardized cell processing protocols and associated quality control mechanisms. The aims here were to develop such an infrastructure in support of the Cardiovascular Cell Therapy Research Network (CCTRN) and to report on the results of processing for the first 60 patients. Methods Standardized cell preparations, consisting of autologous bone marrow mononuclear cells, prepared using the Sepax device were manufactured at each of the five processing facilities that supported the clinical treatment centers. Processing staff underwent centralized training that included proficiency evaluation. Quality was subsequently monitored by a central quality control program that included product evaluation by the CCTRN biorepositories. Results Data from the first 60 procedures demonstrate that uniform products, that met all release criteria, could be manufactured at all five sites within 7 hours of receipt of the bone marrow. Uniformity was facilitated by use of the automated systems (the Sepax for processing and the Endosafe device for endotoxin testing), standardized procedures and centralized quality control. Conclusions Complex multicenter cell therapy and regenerative medicine protocols can, where necessary, successfully utilize local processing facilities once an effective infrastructure is in place to provide training, and quality control. PMID:20524773

Grid site availability evaluation and monitoring at CMS

DOE PAGES

Lyons, Gaston; Maciulaitis, Rokas; Bagliesi, Giuseppe; ...

2017-10-01

The Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) uses distributed grid computing to store, process, and analyse the vast quantity of scientific data recorded every year. The computing resources are grouped into sites and organized in a tiered structure. Each site provides computing and storage to the CMS computing grid. Over a hundred sites worldwide contribute with resources from hundred to well over ten thousand computing cores and storage from tens of TBytes to tens of PBytes. In such a large computing setup scheduled and unscheduled outages occur continually and are not allowed to significantly impactmore » data handling, processing, and analysis. Unscheduled capacity and performance reductions need to be detected promptly and corrected. CMS developed a sophisticated site evaluation and monitoring system for Run 1 of the LHC based on tools of the Worldwide LHC Computing Grid. For Run 2 of the LHC the site evaluation and monitoring system is being overhauled to enable faster detection/reaction to failures and a more dynamic handling of computing resources. Furthermore, enhancements to better distinguish site from central service issues and to make evaluations more transparent and informative to site support staff are planned.« less

Grid site availability evaluation and monitoring at CMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyons, Gaston; Maciulaitis, Rokas; Bagliesi, Giuseppe

The Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) uses distributed grid computing to store, process, and analyse the vast quantity of scientific data recorded every year. The computing resources are grouped into sites and organized in a tiered structure. Each site provides computing and storage to the CMS computing grid. Over a hundred sites worldwide contribute with resources from hundred to well over ten thousand computing cores and storage from tens of TBytes to tens of PBytes. In such a large computing setup scheduled and unscheduled outages occur continually and are not allowed to significantly impactmore » data handling, processing, and analysis. Unscheduled capacity and performance reductions need to be detected promptly and corrected. CMS developed a sophisticated site evaluation and monitoring system for Run 1 of the LHC based on tools of the Worldwide LHC Computing Grid. For Run 2 of the LHC the site evaluation and monitoring system is being overhauled to enable faster detection/reaction to failures and a more dynamic handling of computing resources. Furthermore, enhancements to better distinguish site from central service issues and to make evaluations more transparent and informative to site support staff are planned.« less

Grid site availability evaluation and monitoring at CMS

NASA Astrophysics Data System (ADS)

Lyons, Gaston; Maciulaitis, Rokas; Bagliesi, Giuseppe; Lammel, Stephan; Sciabà, Andrea

2017-10-01

The Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) uses distributed grid computing to store, process, and analyse the vast quantity of scientific data recorded every year. The computing resources are grouped into sites and organized in a tiered structure. Each site provides computing and storage to the CMS computing grid. Over a hundred sites worldwide contribute with resources from hundred to well over ten thousand computing cores and storage from tens of TBytes to tens of PBytes. In such a large computing setup scheduled and unscheduled outages occur continually and are not allowed to significantly impact data handling, processing, and analysis. Unscheduled capacity and performance reductions need to be detected promptly and corrected. CMS developed a sophisticated site evaluation and monitoring system for Run 1 of the LHC based on tools of the Worldwide LHC Computing Grid. For Run 2 of the LHC the site evaluation and monitoring system is being overhauled to enable faster detection/reaction to failures and a more dynamic handling of computing resources. Enhancements to better distinguish site from central service issues and to make evaluations more transparent and informative to site support staff are planned.

AmeriFlux US-MOz Missouri Ozark Site

DOE Data Explorer

Gu, Lianhong [Oak Ridge National Laboratory

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-MOz Missouri Ozark Site. Site Description - The site is located in the University of Missouri Baskett Wildlife Research area, situated in the Ozark region of central Missouri. The site is uniquely located in the ecologically important transitional zone between the central hardwood region and the central grassland region of the US. The land has been publically owned since the 1930s, and is on a land tract that was forested with the same dominant species before settlement in the early 1800s.

Assessment of Marine Coatings at a Central California Static Immersion Test Site

DTIC Science & Technology

2016-10-27

VA 220600-6218 RE: Contract Number N00014-15-1-2321 Assessment of Marine Coatings at a Central California Static Immersion Test Site Principal...Technical Report 05/01/2015 - 07/29/2016 Assessment of Marine Coatings at a Central California Static Immersion Test Site Dean E. Wendt Cal Poly...to test the relationships between the recruitment of fouling organisms to intersite panels and water quality parameters. The static immersion site

Variability in carbon dioxide fluxes for dense urban, suburban and woodland environments in southern England

NASA Astrophysics Data System (ADS)

Ward, Helen; Kotthaus, Simone; Grimmond, C. Sue; Bjorkegren, Alex; Wilkinson, Matt; Morrison, Will; Evans, Jon; Morison, James; Christen, Andreas

2014-05-01

The net exchange of carbon dioxide between the surface and atmosphere can be measured using the eddy covariance technique. Fluxes from a dense urban environment (central London), a suburban landscape (Swindon) and a woodland ecosystem (Alice Holt) are compared. All sites are located in southern England and experience similar climatic and meteorological conditions, yet have very different land cover. The signatures of anthropogenic and biogenic processes are explored at various (daily, seasonal and annual) timescales. Particular emphasis is placed on identifying the mixture of controls that determine the flux. In summer, there are clear similarities between the suburban and woodland sites, as the diurnal behaviour is dominated by photosynthetic uptake. In winter, however, vegetation is largely dormant and human activity determines the pattern of fluxes at the urban and suburban sites. Emissions from building heating augment the net release of carbon dioxide in cold months. Road use is a major contributor to the total emissions, and the diurnal cycle in the observed fluxes reflects this: in central London roads are busy throughout the day, whereas in Swindon a double-peaked rush-hour signal is evident. The net exchange of carbon dioxide is estimated for each site and set in context with other studies around the world. Central London has the smallest proportion of vegetation and largest emissions amongst study sites in the literature to date. Although Swindon's appreciable vegetation fraction helps to offset the anthropogenic emissions, even in summertime the 24h total flux is usually positive, indicating carbon release. Comparison of these three sites in a similar region demonstrates the effects of increasing urban density and changing land use on the atmosphere. Findings are relevant in terms of characterising the behaviour of urban surfaces and for quantifying the impact of anthropogenic activities.

Measuring and computing natural ground-water recharge at sites in south-central Kansas

USGS Publications Warehouse

Sophocleous, M.A.; Perry, C.A.

1987-01-01

To measure the natural groundwater recharge process, two sites in south-central Kansas were instrumented with sensors and data microloggers. The atmospheric-boundary layer and the unsaturated and saturated soil zones were monitored as a single regime. Direct observations also were used to evaluate the measurements. Atmospheric sensors included an anemometer, a tipping-bucket rain gage, an air-temperature thermistor, a relative-humidity probe, a net radiometer, and a barometric-pressure transducer. Sensors in the unsaturated zone consisted of soil-temperature thermocouples, tensiometers coupled with pressure transducers and dial gages, gypsum blocks, and a neutron-moisture probe. The saturated-zone sensors consisted of a water-level pressure transducer, a conventional float gage connected to a variable potentiometer, soil thermocouples, and a number of multiple-depth piezometers. Evaluation of the operation of these sensors and recorders indicates that certain types of equipment, such as pressure transducers, are very sensitive to environmental conditions. A number of suggestions aimed at improving instrumentation of recharge investigations are outlined. Precipitation and evapotranspiration data, taken together with soil moisture profiles and storage changes, water fluxes in the unsaturated zone and hydraulic gradients in the saturated zone at various depths, soil temperature, water table hydrographs, and water level changes in nearby wells, describe the recharge process. Although the two instrumented sites are located in sand-dune environments in area characterized by a shallow water table and a sub-humid continental climate, a significant difference was observed in the estimated total recharge. The estimates ranged from less than 2.5 mm at the Zenith site to approximately 154 mm at the Burrton site from February to June 1983. The principal reasons that the Burrton site had more recharge than the Zenith site were more precipitation, less evapotranspiration, and a shallower depth to the water table. Effective recharge took place only during late winter and spring. No summer or fall recharge was observed at either site during the observation period of this study. (Author 's abstract)

Clinical Decision Support for a Multicenter Trial of Pediatric Head Trauma

PubMed Central

Swietlik, Marguerite; Deakyne, Sara; Hoffman, Jeffrey M.; Grundmeier, Robert W.; Paterno, Marilyn D.; Rocha, Beatriz H.; Schaeffer, Molly H; Pabbathi, Deepika; Alessandrini, Evaline; Ballard, Dustin; Goldberg, Howard S.; Kuppermann, Nathan; Dayan, Peter S.

2016-01-01

Summary Introduction For children who present to emergency departments (EDs) due to blunt head trauma, ED clinicians must decide who requires computed tomography (CT) scanning to evaluate for traumatic brain injury (TBI). The Pediatric Emergency Care Applied Research Network (PECARN) derived and validated two age-based prediction rules to identify children at very low risk of clinically-important traumatic brain injuries (ciTBIs) who do not typically require CT scans. In this case report, we describe the strategy used to implement the PECARN TBI prediction rules via electronic health record (EHR) clinical decision support (CDS) as the intervention in a multicenter clinical trial. Methods Thirteen EDs participated in this trial. The 10 sites receiving the CDS intervention used the Epic® EHR. All sites implementing EHR-based CDS built the rules by using the vendor’s CDS engine. Based on a sociotechnical analysis, we designed the CDS so that recommendations could be displayed immediately after any provider entered prediction rule data. One central site developed and tested the intervention package to be exported to other sites. The intervention package included a clinical trial alert, an electronic data collection form, the CDS rules and the format for recommendations. Results The original PECARN head trauma prediction rules were derived from physician documentation while this pragmatic trial led each site to customize their workflows and allow multiple different providers to complete the head trauma assessments. These differences in workflows led to varying completion rates across sites as well as differences in the types of providers completing the electronic data form. Site variation in internal change management processes made it challenging to maintain the same rigor across all sites. This led to downstream effects when data reports were developed. Conclusions The process of a centralized build and export of a CDS system in one commercial EHR system successfully supported a multicenter clinical trial. PMID:27437059

Geoscientific Site Evaluation Approach for Canada's Deep Geological Repository for Used Nuclear Fuel

NASA Astrophysics Data System (ADS)

Sanchez-Rico Castejon, M.; Hirschorn, S.; Ben Belfadhel, M.

2015-12-01

The Nuclear Waste Management Organization (NWMO) is responsible for implementing Adaptive Phased Management, the approach selected by the Government of Canada for long-term management of used nuclear fuel generated by Canadian nuclear reactors. The ultimate objective of APM is the centralized containment and isolation of Canada's used nuclear fuel in a Deep Geological Repository in a suitable crystalline or sedimentary rock formation. In May 2010, the NWMO published and initiated a nine-step site selection process to find an informed and willing community to host a deep geological repository for Canada's used nuclear fuel. The site selection process is designed to address a broad range of technical and social, economic and cultural factors. The site evaluation process includes three main technical evaluation steps: Initial Screenings; Preliminary Assessments; and Detailed Site Characterizations, to assess the suitability of candidate areas in a stepwise manner over a period of many years. By the end of 2012, twenty two communities had expressed interest in learning more about the project. As of July 2015, nine communities remain in the site selection process. To date (July 2015), NWMO has completed Initial Screenings for the 22 communities that expressed interest, and has completed the first phase of Preliminary Assessments (desktop) for 20 of the communities. Phase 2 of the Preliminary Assessments has been initiated in a number of communities, with field activities such as high-resolution airborne geophysical surveys and geological mapping. This paper describes the approach, methods and criteria being used to assess the geoscientific suitability of communities currently involved in the site selection process.

ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data.

PubMed

Carter, Kim W; Francis, Richard W; Carter, K W; Francis, R W; Bresnahan, M; Gissler, M; Grønborg, T K; Gross, R; Gunnes, N; Hammond, G; Hornig, M; Hultman, C M; Huttunen, J; Langridge, A; Leonard, H; Newman, S; Parner, E T; Petersson, G; Reichenberg, A; Sandin, S; Schendel, D E; Schalkwyk, L; Sourander, A; Steadman, C; Stoltenberg, C; Suominen, A; Surén, P; Susser, E; Sylvester Vethanayagam, A; Yusof, Z

2016-04-01

Research studies exploring the determinants of disease require sufficient statistical power to detect meaningful effects. Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. Methods that facilitate the sharing of research data that are sympathetic with these issues and which allow flexible and detailed statistical analyses are therefore in critical need. We have created a software platform for the Virtual Pooling and Analysis of Research data (ViPAR), which employs free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations. Database federation permits controlled access to remotely located datasets from a central location. The Secure Shell protocol allows data to be securely exchanged between devices over an insecure network. ViPAR combines these free technologies into a solution that facilitates 'virtual pooling' where data can be temporarily pooled into computer memory and made available for analysis without the need for permanent central storage. Within the ViPAR infrastructure, remote sites manage their own harmonized research dataset in a database hosted at their site, while a central server hosts the data federation component and a secure analysis portal. When an analysis is initiated, requested data are retrieved from each remote site and virtually pooled at the central site. The data are then analysed by statistical software and, on completion, results of the analysis are returned to the user and the virtually pooled data are removed from memory. ViPAR is a secure, flexible and powerful analysis platform built on open source technology that is currently in use by large international consortia, and is made publicly available at [http://bioinformatics.childhealthresearch.org.au/software/vipar/]. © The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association.

Sources and formation processes of water-soluble dicarboxylic acids, ω-oxocarboxylic acids, α-dicarbonyls, and major ions in summer aerosols from eastern central India

NASA Astrophysics Data System (ADS)

Deshmukh, Dhananjay K.; Kawamura, Kimitaka; Deb, Manas K.; Boreddy, Suresh K. R.

2017-03-01

The sources and formation processes of dicarboxylic acids are still under investigation. Size-segregated aerosol (nine-size) samples collected in the urban site (Raipur: 21.2°N and 82.3°E) in eastern central India during summer of 2013 were measured for water-soluble diacids (C2-C12), ω-oxoacids (ωC2-ωC9), α-dicarbonyls (C2-C3), and inorganic ions to better understand their sources and formation processes. Diacids showed the predominance of oxalic acid (C2), whereas ω-oxoacids showed the predominance of glyoxylic acid (ωC2), and glyoxal (Gly) was a major α-dicarbonyl in all the sizes. Diacids, ω-oxoacids, and α-dicarbonyls as well as SO42

Indico central - events organisation, ergonomics and collaboration tools integration

NASA Astrophysics Data System (ADS)

Benito Gonzélez López, José; Ferreira, José Pedro; Baron, Thomas

2010-04-01

While the remote collaboration services at CERN slowly aggregate around the Indico event management software, its new version which is the result of a careful maturation process includes improvements which will set a new reference in its domain. The presentation will focus on the description of the new features of the tool, the user feedback process which resulted in a new record of usability. We will also describe the interactions with the worldwide community of users and server administrators and the impact this has had on our development process, as well as the tools set in place to streamline the work between the different collaborating sites. A last part will be dedicated to the use of Indico as a central hub for operating other local services around the event organisation (registration epayment, audiovisual recording, webcast, room booking, and videoconference support)

Dynamic conversion of solar generated heat to electricity

NASA Technical Reports Server (NTRS)

Powell, J. C.; Fourakis, E.; Hammer, J. M.; Smith, G. A.; Grosskreutz, J. C.; Mcbride, E.

1974-01-01

The effort undertaken during this program led to the selection of the water-superheated steam (850 psig/900 F) crescent central receiver as the preferred concept from among 11 candidate systems across the technological spectrum of the dynamic conversion of solar generated heat to electricity. The solar power plant designs were investigated in the range of plant capacities from 100 to 1000 Mw(e). The investigations considered the impacts of plant size, collector design, feed-water temperature ratio, heat rejection equipment, ground cover, and location on solar power technical and economic feasibility. For the distributed receiver systems, the optimization studies showed that plant capacities less than 100 Mw(e) may be best. Although the size of central receiver concepts was not parametrically investigated, all indications are that the optimal plant capacity for central receiver systems will be in the range from 50 to 200 Mw(e). Solar thermal power plant site selection criteria and methodology were also established and used to evaluate potentially suitable sites. The result of this effort was to identify a site south of Inyokern, California, as typically suitable for a solar thermal power plant. The criteria used in the selection process included insolation and climatological characteristics, topography, and seismic history as well as water availability.

A Software Defined Radio Based Architecture for the Reagan Test Site Telemetry Modernization (RTM) Program

DTIC Science & Technology

2015-10-26

platforms and are quickly using up available spectrum. The national need in the commercial sector with emerging technologies such as 5G is pushing for...recovered and post processed later. The Front End Server also sends selected data stream across a high speed network link to the centralized

Educational Reforms in Malta: A Missed Opportunity to Establish Distributed Governance

ERIC Educational Resources Information Center

Cutajar, Mario; Bezzina, Christopher; James, Chris

2013-01-01

This article critically analyses the current Maltese educational reform process, which aimed to transform educational governance in Malta from a centralized system to a more decentralized one. This longitudinal study adopted a multi-site inquiry of a sample of the colleges involving different stakeholders, including key policy-makers, college…

The Interface of Pacific and Other Knowledges in a Supplementary Education Site

ERIC Educational Resources Information Center

Fairbairn-Dunlop, Peggy

2014-01-01

Because identity (language and culture) are central to Pacific knowledge and knowledge construction processes, Pacific students' educational experiences should be viewed through a cultural lens that sees Pacific knowledge and practices as valid and valued. This study explores the relationship between culture and educational outcomes as seen in how…

KENNEDY SPACE CENTER, FLA. - - U.S. Representative Ric Keller (left) listens intently to a presentation proposing the use of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. NASA and Florida officials toured the research park as well. Central Florida leaders are proposing the research park as the site for the center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - - U.S. Representative Ric Keller (left) listens intently to a presentation proposing the use of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. NASA and Florida officials toured the research park as well. Central Florida leaders are proposing the research park as the site for the center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (center) is welcomed to the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (center) is welcomed to the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Chemical weathering of palaeosols from the Lower Palaeolithic site of Valle Giumentina, central Italy

NASA Astrophysics Data System (ADS)

Degeai, Jean-Philippe; Villa, Valentina; Chaussé, Christine; Pereira, Alison; Nomade, Sébastien; Aureli, Daniele; Pagli, Marina; Nicoud, Elisa

2018-03-01

The major archaeological site of Valle Giumentina (Abruzzo) contains a well-dated Lower Palaeolithic pedosedimentary sequence that provides an excellent opportunity to study the relationships among soil weathering, volcanism and climate change at the glacial/interglacial and submillennial timescales in central Italy and the Mediterranean area during the Middle Pleistocene, as well as the human-environment interactions of some of the earliest settlements in central southern Europe. High-resolution analyses of geochemistry and magnetic susceptibility revealed the presence of eleven palaeosols, ten of which (S2-S11) were formed between 560 and 450 ka based on 40Ar/39Ar dating of sanidine in tephras, i.e. spanning marine isotope stages (MIS) 14-12. The evolution of the major and trace element composition suggests that the palaeosols were mainly formed by in situ weathering of the parent material. The major phases of soil weathering occurred during the MIS 13 interglacial period (S8 and S6) as well as during episodes of rapid environmental change associated with millennial climatic oscillations during the MIS 14 and 12 glaciations (S11 and S2, respectively). Although global forcing such as orbital variations, solar radiation, and greenhouse gas concentrations may have influenced the pedogenic processes, the volcanism in central Italy, climate change in the central Mediterranean, and tectono-sedimentary evolution of the Valle Giumentina basin also impacted and triggered the formation of most palaeosols, which provided subsistence resources for the Lower Palaeolithic human communities. This study highlights the importance of having high-resolution palaeoenvironmental records with accurate chronology as close as possible to archaeological sites to study human-environment interactions.

Circuit-Detour Design and Implementation - Enhancing the Southern California's Seismic Network Reliability through Redundant Network Paths

NASA Astrophysics Data System (ADS)

Watkins, M.; Busby, R.; Rico, H.; Johnson, M.; Hauksson, E.

2003-12-01

We provide enhanced network robustness by apportioning redundant data communications paths for seismic stations in the field. By providing for more than one telemetry route, either physical or logical, network operators can improve availability of seismic data while experiencing occasional network outages, and also during the loss of key gateway interfaces such as a router or central processor. This is especially important for seismic stations in sparsely populated regions where a loss of a single site may result in a significant gap in the network's monitoring capability. A number of challenges arise in the application of a circuit-detour mechanism. One requirement is that it fits well within the existing framework of our real-time system processing. It is also necessary to craft a system that is not needlessly complex to maintain or implement, particularly during a crisis. The method that we use for circuit-detours does not require the reconfiguration of dataloggers or communications equipment in the field. Remote network configurations remain static, changes are only required at the central site. We have implemented standardized procedures to detour circuits on similar transport mediums, such as virtual circuits on the same leased line; as well as physically different communications pathways, such as a microwave link backed up by a leased line. The lessons learned from these improvements in reliability, and optimization efforts could be applied to other real-time seismic networks. A fundamental tenant of most seismic networks is that they are reliable and have a high percentage of real-time data availability. A reasonable way to achieve these expectations is to provide alternate means of delivering data to the central processing sites, with a simple method for utilizing these alternate paths.

Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics.

PubMed

Hirsch, B; Endris, V; Lassmann, S; Weichert, W; Pfarr, N; Schirmacher, P; Kovaleva, V; Werner, M; Bonzheim, I; Fend, F; Sperveslage, J; Kaulich, K; Zacher, A; Reifenberger, G; Köhrer, K; Stepanow, S; Lerke, S; Mayr, T; Aust, D E; Baretton, G; Weidner, S; Jung, A; Kirchner, T; Hansmann, M L; Burbat, L; von der Wall, E; Dietel, M; Hummel, M

2018-04-01

The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based targeted next-generation sequencing (NGS). However, only few studies are available comparing multicenter testing of different NGS platforms and gene panels. Therefore, seven partner sites of the German Cancer Consortium (DKTK) performed a multicenter interlaboratory trial for targeted NGS using the same formalin-fixed, paraffin-embedded (FFPE) specimen of molecularly pre-characterized tumors (n = 15; each n = 5 cases of Breast, Lung, and Colon carcinoma) and a colorectal cancer cell line DNA dilution series. Detailed information regarding pre-characterized mutations was not disclosed to the partners. Commercially available and custom-designed cancer gene panels were used for library preparation and subsequent sequencing on several devices of two NGS different platforms. For every case, centrally extracted DNA and FFPE tissue sections for local processing were delivered to each partner site to be sequenced with the commercial gene panel and local bioinformatics. For cancer-specific panel-based sequencing, only centrally extracted DNA was analyzed at seven sequencing sites. Subsequently, local data were compiled and bioinformatics was performed centrally. We were able to demonstrate that all pre-characterized mutations were re-identified correctly, irrespective of NGS platform or gene panel used. However, locally processed FFPE tissue sections disclosed that the DNA extraction method can affect the detection of mutations with a trend in favor of magnetic bead-based DNA extraction methods. In conclusion, targeted NGS is a very robust method for simultaneous detection of various mutations in FFPE tissue specimens if certain pre-analytical conditions are carefully considered.

Mars Surface System Common Capabilities and Challenges for Human Missions

NASA Technical Reports Server (NTRS)

Hoffman, Stephen J.; Toups, Larry

2016-01-01

NASA has begun a process to identify and evaluate candidate locations where humans could land, live and work on the martian surface. These locations are referred to as Exploration Zones (EZs). Given current mission concepts, an EZ is a collection of Regions of Interest (ROIs) that are located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains a landing site and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. In parallel with this process, NASA continues to make progress on the Evolvable Mars Campaign examining alternatives that can pioneer an extended human presence on Mars that is Earth independent. This involves ongoing assessments of surface systems and operations to enable a permanent, sustainable human presence. Because of the difficulty in getting equipment and supplies to the surface of Mars, part of these assessments involve identifying those systems and processes that can perform in multiple, sometimes completely unrelated, situations. These assessments have been performed in a very generic surface mission carried out at a very generic surface location. As specific candidate EZs are identified it becomes important to evaluate the current suite of surface systems and operations as they are likely to perform for the specific locations and for the types of operations - both scientific and development - that are proposed for these EZs. It is also important to evaluate the proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. This means looking at setting up and operating a field station at a central location within the EZ as well as traversing to and exploring the scientific ROIs within the boundaries of the EZ. The proposed paper will describe the current status of common systems and operations as they can be applied to actual EZ locations on Mars. Initially these EZs will be the four locations identified MEPAG's Human Exploration of Mars Science Analysis Group (HEM-SAG) that will be used as representative of the EZs that will emerge from the process that NASA has initiated. An example process that could be commonly applied is an approach for developing a field station site plan that would be demonstrated by applying this process to each of the four HEM-SAG sites. Examples of common systems include (a) mobility systems that can be used to off-load and move payloads to specific locations at the central field station location that could also be used to traverse long distances to reach some of the more remote ROIs or (b) robotic systems that can support various activities (such as system set up and maintenance) at the field station that could also be used to explore scientific ROIs and used to support site-specific ISRU production activities.

UV disinfection pilot plant study at the Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huffines, R.L.; Beavers, B.A.

1993-05-01

An ultraviolet light disinfection system pilot plant was operated at the Savannah River Site Central Shops sanitary wastewater treatment package plant July 14, 1992 through August 13, 1992. The purpose was to determine the effectiveness of ultraviolet light disinfection on the effluent from the small package-type wastewater treatment plants currently used on-site. This pilot plant consisted of a rack of UV lights suspended in a stainless steel channel through which a sidestream of effluent from the treatment plant clarifier was pumped. Fecal coliform analyses were performed on the influent to and effluent from the pilot unit to verify the disinfectionmore » process. UV disinfection was highly effective in reducing fecal coliform colonies within NPDES permit limitations even under process upset conditions. The average fecal coliform reduction exceeded 99.7% using ultraviolet light disinfection under normal operating conditions at the package treatment plants.« less

UV disinfection pilot plant study at the Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huffines, R.L.; Beavers, B.A.

1993-01-01

An ultraviolet light disinfection system pilot plant was operated at the Savannah River Site Central Shops sanitary wastewater treatment package plant July 14, 1992 through August 13, 1992. The purpose was to determine the effectiveness of ultraviolet light disinfection on the effluent from the small package-type wastewater treatment plants currently used on-site. This pilot plant consisted of a rack of UV lights suspended in a stainless steel channel through which a sidestream of effluent from the treatment plant clarifier was pumped. Fecal coliform analyses were performed on the influent to and effluent from the pilot unit to verify the disinfectionmore » process. UV disinfection was highly effective in reducing fecal coliform colonies within NPDES permit limitations even under process upset conditions. The average fecal coliform reduction exceeded 99.7% using ultraviolet light disinfection under normal operating conditions at the package treatment plants.« less

Baseline Caesium-137 and Plutonium-239+240 inventory assessment for Central Europe

NASA Astrophysics Data System (ADS)

Meusburger, Katrin; Borelli, Pasquale; Evrard, Olivier; Ketterer, Michael; Mabit, Lionel; van Oost, Kristof; Alewell, Christine; Panagos, Panos

2017-04-01

Artificial fallout radionuclides (FRNs) such as Caesium-137 and Plutonium-239+240 released as products of the thermonuclear weapons testing that took place from the mid-1950s to the early 1980s and from nuclear power plant accidents (e.g. Chernobyl) are useful tools to quantify soil redistribution. In combination with geostatistics, FRNs may have the potential to bridge the gap between small scale process oriented studies and modelling that simplifies processes and effects over large spatial scales. An essential requirement for the application of FRNs as soil erosion tracers is the establishment of the baseline fallout at undisturbed sites before its comparison to those inventories found at sites undergoing erosion/accumulation. For this purpose, undisturbed topsoil (0-20cm) samples collected in 2009 within the framework of the Land Use/Cover Area frame Survey (LUCAS) have been measured by gamma-spectrometry and ICP-MS to determine 137Cs (n=145) and 239+240Pu (n=108) activities. To restrict the analysis to undisturbed reference sites a geospatial database query selecting only sites having a slope angle <2 degree, outside riparian zones (to avoid depositional sites) and under permanent grassland cover (according to CORINE Land Cover and Landsat) was applied. This study reports preliminary results on the feasibility of establishing a 137Cs and 239+240Pu baseline inventory map for Central Europe. The 137Cs/239+240Pu activity ratios will further allow assessing the rate and the spatial variability of 137Cs Chernobyl fallout. The establishment of such baseline inventory map will provide a unique opportunity to assess soil redistribution for a comparable time-frame (1953-2009) following a harmonised methodological protocol across national boundaries.

System integration of marketable subsystems

NASA Technical Reports Server (NTRS)

1978-01-01

These monthly reports, covering the period February 1978 through June 1978, describe the progress made in the major areas of the program. The areas covered are: systems integration of marketable subsystems; development, design, and building of site data acquisition subsystems; development and operation of the central data processing system; operation of the MSFC Solar Test Facility; and systems analysis.

78 FR 31985 - Atomic Safety and Licensing Board Panel; Before the Licensing Board: G. Paul Bollwerk, III...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... authorizes the operation of CBR's existing in situ uranium recovery (ISR) facility near Crawford, Nebraska... operate a satellite ISR facility, the Marsland Expansion Area (MEA) site, which is located in Dawes County, Nebraska, some eleven miles to the southeast of CBR's Crawford central processing facility. In response to...

[Medical specialization in Chile. A centralized vision].

PubMed

Clouet-Huerta, Diego E; González, Bárbara; Correa, Katherine

2017-11-01

Medical graduates face different postgraduate training options, but their priority is to obtain a primary medical specialty, defined as a specialty that does not derive from other. There are different specialty training programs in Chile, which can be dependent or independent of the Ministry of Health. The information about these programs is available in different Internet sites. However a centralized information service that groups and synthetize these programs is lacking, hampering graduate choice decisions. This article aims to review all specialization program modalities, providing a general vision of the institutional structure and implications that govern the specialization process in Chile.

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (left) greets U.S. Representative Ric Keller during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (left) greets U.S. Representative Ric Keller during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (right) greets Florida Congressman Tom Feeney during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (right) greets Florida Congressman Tom Feeney during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo.

PubMed

Sun, Yidi; Leong, Nicole T; Jiang, Tommy; Tangara, Astou; Darzacq, Xavier; Drubin, David G

2017-08-16

Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs) such as WASP, plays an important role in many actin-mediated cellular processes. In yeast, Arp2/3-mediated actin filament assembly drives endocytic membrane invagination and vesicle scission. Here we used genetics and quantitative live-cell imaging to probe the mechanisms that concentrate NPFs at endocytic sites, and to investigate how NPFs regulate actin assembly onset. Our results demonstrate that SH3 (Src homology 3) domain-PRM (proline-rich motif) interactions involving multivalent linker proteins play central roles in concentrating NPFs at endocytic sites. Quantitative imaging suggested that productive actin assembly initiation is tightly coupled to accumulation of threshold levels of WASP and WIP, but not to recruitment kinetics or release of autoinhibition. These studies provide evidence that WASP and WIP play central roles in establishment of a robust multivalent SH3 domain-PRM network in vivo, giving actin assembly onset at endocytic sites a switch-like behavior.

Nest Site Characteristics of Cavity Nesting Birds in Central Missouri

Treesearch

Jeffery D. Brawn; Bernice Tannenbaum; Keith E. Evans

1984-01-01

Two study sites in central Missouri oak-hickory forests were searched for nest sites of cavity nesting birds. Researchers located and measured 133 nests of 11 species. Cavity nesting bird habitat selection is affected by both snag characteristics and vegetation structure.

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.

PubMed

Chen, Ko-Fan; Possidente, Bernard; Lomas, David A; Crowther, Damian C

2014-04-01

Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer's disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosophila expressing the amyloid beta peptide (Aβ). We find that Aβ expression results in an age-related loss of circadian behavioural rhythms despite ongoing normal molecular oscillations in the central clock neurons. Even in the absence of any behavioural correlate, the synchronised activity of the central clock remains protective, prolonging lifespan, in Aβ flies just as it does in control flies. Confocal microscopy and bioluminescence measurements point to processes downstream of the molecular clock as the main site of Aβ toxicity. In addition, there seems to be significant non-cell-autonomous Aβ toxicity resulting in morphological and probably functional signalling deficits in central clock neurons.

Qualitative evaluation of the mineralogical and chemical composition of dry deposition in the central and southern highlands of Jordan.

PubMed

Jiries, Anwar; El-Hasan, Tayel; Manasrah, Walid

2002-09-01

The chemical and mineralogical composition of dry deposition in the western highlands of central and south Jordan at the end of the summer season 2000, reflect the composition of soils in addition to anthropogenic activities at these areas. Calcite predominated in the central region whereas calcite and quartz are the dominant minerals in south Jordan. The concentrations of Hg, Cr, Ni, Cu, Pb and Zn were higher in central Jordan, which might be attributed to higher anthropogenic activities than south. On the other hand, Fe, Mn, Ti, Ba, Sr, Y and Rb were higher in the south of Jordan reflecting the composition of soil at these sites. At Aqaba city, the only port of Jordan, where Cr, Cd, As and S were higher than other areas. This variation might be attributed to the contribution of phosphate dust in the atmosphere through handling processes.

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

PubMed Central

Chen, Ko-Fan; Possidente, Bernard; Lomas, David A.; Crowther, Damian C.

2014-01-01

Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer’s disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosophila expressing the amyloid beta peptide (Aβ). We find that Aβ expression results in an age-related loss of circadian behavioural rhythms despite ongoing normal molecular oscillations in the central clock neurons. Even in the absence of any behavioural correlate, the synchronised activity of the central clock remains protective, prolonging lifespan, in Aβ flies just as it does in control flies. Confocal microscopy and bioluminescence measurements point to processes downstream of the molecular clock as the main site of Aβ toxicity. In addition, there seems to be significant non-cell-autonomous Aβ toxicity resulting in morphological and probably functional signalling deficits in central clock neurons. PMID:24574361

Assessment of Accumulation Processes at the Middle Pleistocene Site of Ambrona (Soria, Spain). Density and Orientation Patterns in Spatial Datasets Derived from Excavations Conducted from the 1960s to the Present

PubMed Central

Sánchez-Romero, Laura; Benito-Calvo, Alfonso; Pérez-González, Alfredo; Santonja, Manuel

2016-01-01

The Middle Pleistocene site of Ambrona (Soria, Spain) is a major reference for European Acheulean studies. The origin of the lithic and fauna accumulations at this site was first thought to be anthropogenic, but later studies showed that it was mainly natural. The first person to conduct excavations at the Ambrona site was the Marquis of Cerralbo, in 1914; other research groups followed in more recent times (the Howell & Freeman team and the Santonja & Pérez-González team). The digs yielded a great amount of information, but until now it had never been unified. In this paper, we compile all the available published and unpublished excavation documentation from the 1960s to the present. We use these maps and sections to present our spatial study of the LSM (Lower Stratigraphic Member) at the Ambrona site, combining stratigraphic criteria with GIS density and orientation analysis. This study enabled us to define the main concentrations of the LSM, providing an initial contribution to an assessment of their accumulation processes. Most of the concentrations preserved in the ancient shore area of the site display marked orientation patterns which coincide with the direction of the main water flows into the Ambrona wetland. However, random orientation patterns were observed in the central part of the site (Alpha concentration); they may be mostly preserved without undergoing transport processes, as previous taphonomic studies also confirm. PMID:28002424

Landscape patterns around Northern Spotted Owl (Strix occidentalis caurina) nest sites in Oregon's central Coast Ranges

Treesearch

J. P. Perkins; J. A. Thrailkill; W. J. Ripple; K. T. Hershey

1997-01-01

We investigated landscape characteristics around 41 Northern Spotted Owl (Strix occidentalis caurina) nest sites to assess habitat proportions and patterns on this highly fragmented landscape in the central Coast Ranges of Oregon. We compared the proportion of seven forest cover-types between nest sites and random sites at plot sizes of 112 ha, 456...

DNA breaks and end resection measured genome-wide by end sequencing | Center for Cancer Research

Cancer.gov

About the Cover The cover depicts a ribbon of DNA portrayed as a city skyline. The central gap in the landscape localizes to the precise site of the DNA break. The features surrounding the break denote the processing of DNA-end structures (end-resection) emanating from the break location. Cover artwork by Ethan Tyler, NIH. Abstract

Research on centrality of urban transport network nodes

NASA Astrophysics Data System (ADS)

Wang, Kui; Fu, Xiufen

2017-05-01

Based on the actual data of urban transport in Guangzhou, 19,150 bus stations in Guangzhou (as of 2014) are selected as nodes. Based on the theory of complex network, the network model of Guangzhou urban transport is constructed. By analyzing the degree centrality index, betweenness centrality index and closeness centrality index of nodes in the network, the level of centrality of each node in the network is studied. From a different point of view to determine the hub node of Guangzhou urban transport network, corresponding to the city's key sites and major transfer sites. The reliability of the network is determined by the stability of some key nodes (transport hub station). The research of network node centralization can provide a theoretical basis for the rational allocation of urban transport network sites and public transport system planning.

Geology and taphonomy of the L'Espinau dinosaur bonebed, a singular lagoonal site from the Maastrichtian of South-Central Pyrenees

NASA Astrophysics Data System (ADS)

Fondevilla, V.; Vicente, A.; Battista, F.; Sellés, A. G.; Dinarès-Turell, J.; Martín-Closas, C.; Anadón, P.; Vila, B.; Razzolini, N. L.; Galobart, À.; Oms, O.

2017-06-01

The L'Espinau site is a dinosaur bonebed from the Upper Cretaceous of the South-Central Pyrenees (north-eastern Spain) that have provided hundreds of bone remains attributed to hadrosauroids, together with a rich assemblage of herpetofauna, fish and microflora. Magnetostratigraphy calibrated the site with the early late Maastrichtian, and the combined sedimentology, stable isotope geochemistry and palaeoecology revealed that this fossil site formed in a lagoon, in which a mixed freshwater-brackish palaeoenvironment was developed. This setting displays a south-north charophyte zonation from freshwater (Clavator brachycerus-dominated assemblage) to brackish or eurihaline conditions (Feistiella malladae-dominated assemblage), revealing a palaeoenvironment change towards the coast. Sedimentology and taphonomy (bidirectional arrangement of long bones, abrasion and disarticulation) indicate that the L'Espinau site is the result of a cohesive mass flow event originated very close to the sea. This process entrained and mixed fauna from both the terrestrial and the brackish/marine environment of a lagoon. An increasing of the water runoff (e.g. by intense rainfall) reworking poorly consolidated sediments is considered here as the most probable triggering mechanism. Mass flow-hosted bonebeds are commonly linked to fluvial palaeoenvironments, so our study case is a rare example of bones accumulating near the sea. This study adds evidence that hadrosauroids inhabited littoral environments during the Maastrichtian in the southern Pyrenean area.

Computers in anesthesia and intensive care: lack of evidence that the central unit serves as reservoir of pathogens.

PubMed

Quinzio, Lorenzo; Blazek, Michael; Hartmann, Bernd; Röhrig, Rainer; Wille, Burkhard; Junger, Axel; Hempelmann, Gunter

2005-01-01

Computers are becoming increasingly visible in operating rooms (OR) and intensive care units (ICU) for use in bedside documentation. Recently, they have been suspected as possibly acting as reservoirs for microorganisms and vehicles for the transfer of pathogens to patients, causing nosocomial infections. The purpose of this study was to examine the microbiological (bacteriological and mycological) contamination of the central unit of computers used in an OR, a surgical and a pediatric ICU of a tertiary teaching hospital. Sterile swab samples were taken from five sites in each of 13 computers stationed at the two ICUs and 12 computers at the OR. Sample sites within the chassis housing of the computer processing unit (CPU) included the CPU fan, ventilator, and metal casing. External sites were the ventilator and the bottom of the computer tower. Quantitative and qualitative microbiological analyses were performed according to commonly used methods. One hundred and ninety sites were cultured for bacteria and fungi. Analyses of swabs taken at five equivalent sites inside and outside the computer chassis did not find any significant-number of potentially pathogenic bacteria or fungi. This can probably be attributed to either the absence or the low number of pathogens detected on the surfaces. Microbial contamination in the CPU of OR and ICU computers is too low for designating them as a reservoir for microorganisms.

Atmospheric particulate mercury at the urban and forest sites in central Poland.

PubMed

Siudek, Patrycja; Frankowski, Marcin; Siepak, Jerzy

2016-02-01

Particulate mercury concentrations were investigated during intensive field campaigns at the urban and forest sites in central Poland, between April 2013 and October 2014. For the first time, quantitative determination of total particulate mercury in coarse (PHg2.2) and fine (PHg0.7) aerosol samples was conducted in Poznań and Jeziory. The concentrations in urban fine and coarse aerosol fractions amounted to < MDL ± 77.1 pg m(-3) and < MDL ± 604.9 pg m(-3), respectively. Aerosol samples collected during the whole study period showed statistically significant differences for particulate mercury concentrations. A strong impact of meteorological conditions (wind velocity, air mass direction, air temperature, and precipitation amount) on particulate mercury concentrations was also observed. In particular, higher variation and concentration range of PHg0.7 and PHg2.2 was reported for wintertime measurements. An increase in atmospheric particulate mercury during the cold season in the study region indicated that coal combustion, i.e., residential and industrial heating, is the main contribution factor for the selected particle size modes. Coarse particulate Hg at the urban site during summer was mainly attributed to anthropogenic sources, with significant contribution from resuspension processes and long-range transport. The highest values of PHg0.7 and PHg2.2 were found during westerly and southerly wind events, reflecting local emission from highly polluted areas. The period from late fall to spring showed that advection from the southern part of Poland was the main factor responsible for elevated Hg concentrations in fine and coarse particles in the investigated region. Moreover, September 2013 could be given as an example of the influence of additional urban activities which occurred approx. 10 m from the sampling site-construction works connected with replacement of the road surface, asphalting, etc. The concentrations of particulate Hg (>600.0 pg m(-3)) were much higher than during the following months when any similar situation did not occur. Our investigations confirmed that Hg in urban aerosol samples was predominantly related to local industrial and commercial emissions, whereas the main source of Hg in particulate matter collected at the forest site was connected with regional anthropogenic processes. This paper provides the results of the first long-term measurements of size-fractionated particulate mercury conducted in central Poland, which could be an important insight into atmospheric Hg processes within such a scarcely investigated part of Europe.

A new concept for medical imaging centered on cellular phone technology.

PubMed

Granot, Yair; Ivorra, Antoni; Rubinsky, Boris

2008-04-30

According to World Health Organization reports, some three quarters of the world population does not have access to medical imaging. In addition, in developing countries over 50% of medical equipment that is available is not being used because it is too sophisticated or in disrepair or because the health personnel are not trained to use it. The goal of this study is to introduce and demonstrate the feasibility of a new concept in medical imaging that is centered on cellular phone technology and which may provide a solution to medical imaging in underserved areas. The new system replaces the conventional stand-alone medical imaging device with a new medical imaging system made of two independent components connected through cellular phone technology. The independent units are: a) a data acquisition device (DAD) at a remote patient site that is simple, with limited controls and no image display capability and b) an advanced image reconstruction and hardware control multiserver unit at a central site. The cellular phone technology transmits unprocessed raw data from the patient site DAD and receives and displays the processed image from the central site. (This is different from conventional telemedicine where the image reconstruction and control is at the patient site and telecommunication is used to transmit processed images from the patient site). The primary goal of this study is to demonstrate that the cellular phone technology can function in the proposed mode. The feasibility of the concept is demonstrated using a new frequency division multiplexing electrical impedance tomography system, which we have developed for dynamic medical imaging, as the medical imaging modality. The system is used to image through a cellular phone a simulation of breast cancer tumors in a medical imaging diagnostic mode and to image minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode.

Exploring the larval fish community of the central Red Sea with an integrated morphological and molecular approach.

PubMed

Isari, Stamatina; Pearman, John K; Casas, Laura; Michell, Craig T; Curdia, Joao; Berumen, Michael L; Irigoien, Xabier

2017-01-01

An important aspect of population dynamics for coral reef fishes is the input of new individuals from the pelagic larval pool. However, the high biodiversity and the difficulty of identifying larvae of closely related species represent obstacles to more fully understanding these populations. In this study, we combined morphology and genetic barcoding (Cytochrome Oxidase I gene) to characterize the seasonal patterns of the larval fish community at two sites in close proximity to coral reefs in the central-north Red Sea: one shallower inshore location (50 m depth) and a nearby site located in deeper and more offshore waters (~ 500 m depth). Fish larvae were collected using oblique tows of a 60 cm-bongo net (500 μm mesh size) every month for one year (2013). During the warmer period of the year (June-November), the larval fish stock was comparable between sampling sites. However, during the colder months, abundances were higher in the inshore than in the offshore waters. Taxonomic composition and temporal variation of community structure differed notably between sites, potentially reflecting habitat differences, reproductive patterns of adults, and/or advective processes in the area. Eleven out of a total of 62 recorded families comprised 69-94% of the fish larval community, depending on sampling site and month. Richness of taxa was notably higher in the inshore station compared to the offshore, particularly during the colder period of the year and especially for the gobiids and apogonids. Two mesopelagic taxa (Vinciguerria sp. and Benthosema spp.) comprised an important component of the larval community at the deeper site with only a small and sporadic occurrence in the shallower inshore waters. Our data provide an important baseline reference for the larval fish communities of the central Red Sea, representing the first such study from Saudi Arabian waters.

Exploring the larval fish community of the central Red Sea with an integrated morphological and molecular approach

PubMed Central

Pearman, John K.; Casas, Laura; Michell, Craig T.; Curdia, Joao; Berumen, Michael L.; Irigoien, Xabier

2017-01-01

An important aspect of population dynamics for coral reef fishes is the input of new individuals from the pelagic larval pool. However, the high biodiversity and the difficulty of identifying larvae of closely related species represent obstacles to more fully understanding these populations. In this study, we combined morphology and genetic barcoding (Cytochrome Oxidase I gene) to characterize the seasonal patterns of the larval fish community at two sites in close proximity to coral reefs in the central-north Red Sea: one shallower inshore location (50 m depth) and a nearby site located in deeper and more offshore waters (~ 500 m depth). Fish larvae were collected using oblique tows of a 60 cm-bongo net (500 μm mesh size) every month for one year (2013). During the warmer period of the year (June-November), the larval fish stock was comparable between sampling sites. However, during the colder months, abundances were higher in the inshore than in the offshore waters. Taxonomic composition and temporal variation of community structure differed notably between sites, potentially reflecting habitat differences, reproductive patterns of adults, and/or advective processes in the area. Eleven out of a total of 62 recorded families comprised 69–94% of the fish larval community, depending on sampling site and month. Richness of taxa was notably higher in the inshore station compared to the offshore, particularly during the colder period of the year and especially for the gobiids and apogonids. Two mesopelagic taxa (Vinciguerria sp. and Benthosema spp.) comprised an important component of the larval community at the deeper site with only a small and sporadic occurrence in the shallower inshore waters. Our data provide an important baseline reference for the larval fish communities of the central Red Sea, representing the first such study from Saudi Arabian waters. PMID:28771590

The operation of cost-effective on-site process for the bio-treatment of mixed municipal solid waste in rural areas.

PubMed

Wu, Duo; Zhang, Chunyan; Lü, Fan; Shao, Liming; He, Pinjing

2014-06-01

The application of on-site waste treatment significantly reduces the need for expensive waste collection and transportation in rural areas; hence, it is considered of fundamental importance in developing countries. In this study, the effects of in-field operation of two types of mini-scale on-site solid waste treatment facilities on de-centralized communities, one using mesophilic two-phase anaerobic digestion combined with composting (TPAD, 50 kg/d) and another using decentralized composting (DC, 0.6-2 t/d), were investigated. Source-separated collection was applied to provide organic waste for combined process, in which the amount of waste showed significant seasonal variation. The highest collection amount was 0.18 kg/capital day and 0.6 kg/household day. Both sites showed good performance after operating for more than 6 months, with peak waste reduction rates of 53.5% in TPAD process and 63.2% in DC process. Additionally, the windrow temperature exceeded 55 °C for >5 days, indicating that the composting products from both facilities were safe. These results were supported by 4 days aerobic static respiration rate tests. The emissions were low enough to avoid any impact on nearby communities (distance <100 m). Partial energy could be recovered by the combined process but with complicated operation. Hence, the choice of process must be considered in case separately. Copyright © 2013 Elsevier Ltd. All rights reserved.

The role of ecotypic variation and the environment on biomass and nitrogen in a dominant prairie grass.

PubMed

Mendola, Meredith L; Baer, Sara G; Johnson, Loretta C; Maricle, Brian R

2015-09-01

Knowledge of the relative strength of evolution and the environment on a phenotype is required to predict species responses to environmental change and decide where to source plant material for ecological restoration. This information is critically needed for dominant species that largely determine the productivity of the central U.S. grassland. We established a reciprocal common garden experiment across a longitudinal gradient to test whether ecotypic variation interacts with the environment to affect growth and nitrogen (N) storage in a dominant grass. We predicted plant growth would increase from west to east, corresponding with increasing precipitation, but differentially among ecotypes due to local adaptation in all ecotypes and a greater range of growth response in ecotypes originating from west to east. We quantified aboveground biomass, root biomass, belowground net primary production (BNPP), root C:N ratio, and N storage in roots of three ecotypes of Andropogon gerardii collected from and reciprocally planted in central Kansas, eastern Kansas, and s6uthern Illinois. Only the ecotype from the most mesic region (southern Illinois) exhibited more growth from west to east. There was evidence for local adaptation in the southern Illinois ecotype by means of the local vs. foreign contrast within a site and the home vs. away contrast when growth in southern Illinois was compared to the most distant 'site in central Kansas. Root biomass of the eastern Kansas ecotype was higher at home than at either away site. The ecotype from the driest region, central Kansas, exhibited the least response across the environmental gradient, resulting in a positive relationship between the range of biomass response and precipitation in ecotype region of origin. Across all sites, ecotypes varied in root C:N ratio (highest in the driest-origin ecotype) and N storage in roots (highest in the most mesic-origin ecotype). The low and limited range of biomass, higher C:N ratio of roots, and lower N storage in the central Kansas ecotype relative to the southern Illinois ecotype suggests that introducing ecotypes of A. gerardii from much drier regions into highly mesic prairie would reduce productivity and alter belowground ecosystem processes under a wide range of conditions.

Neural correlates of active controlled retrieval development: An exploratory ERP study.

PubMed

Simard, France; Cadoret, Geneviève

2018-07-01

Working memory is composed of different processes and encompasses not only the temporary storage of information but also its manipulation in order to perform complex cognitive activities. During childhood, one of these manipulation processes, namely active controlled retrieval, improves significantly between the age of 6 to 10, suggesting that the neuronal network supporting this function undergoes substantial maturational changes. The present study examined the neural activity of 14 healthy children and 14 adults while performing an active controlled retrieval task. Results showed differences in brain activity according to active controlled retrieval in a 300-500 ms window corresponding to the retrieval period. Active controlled retrieval was associated with a P3b-like potential in parietal sites for both children and adults. In fronto-central sites, children demonstrated a "N400 like" potential associated with active retrieval processing. These results are discussed in terms of maturational development. Copyright © 2018 Elsevier Inc. All rights reserved.

Central Office and Site-Based Management: An Educator's Guide.

ERIC Educational Resources Information Center

Sewall, Angela Maynard

This book describes changes that must be made in central-office administration to facilitate the movement to site-based management. It is intended for educational administrators in central administration or for those who are planning to work as superintendents, business managers, or supervisors of curriculum and instruction. The book covers all…

KENNEDY SPACE CENTER, FLA. - KSC Director Jim Kennedy (center) makes a presentation to NASA and other officials about the benefits of locating NASA’s new Shared Services Center in the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - KSC Director Jim Kennedy (center) makes a presentation to NASA and other officials about the benefits of locating NASA’s new Shared Services Center in the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (center) listens to Congressman Tom Feeney (second from left) during a tour of the Central Florida Research Park, near Orlando. At right is U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe (center) listens to Congressman Tom Feeney (second from left) during a tour of the Central Florida Research Park, near Orlando. At right is U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Regional fuel load modeled for two contrasting years in central and southern Africa

NASA Astrophysics Data System (ADS)

Hely, C.; Dowty, P. R.; Alleaume, S.; Caylor, K. K.; Shugart, H. H.

2001-12-01

Fuel load has been modeled for southern hemisphere Africa for the 1991-92 and 1999-2000 growing seasons. The 1991-92 year was generally dry due to a strong El Nino event in contrast to the particularly wet year of 1999-2000. The method integrates site-level process modeling with 15 day AVHRR NDVI data. The site model was used to simulate landscape light-use efficiency (LUE) at a series of sites in the Kalahari region ranging from evergreen woodland to arid shrubland. This site-level LUE is extrapolated over the southern African region with gridded tree cover data and gridded rainfall. The predicted net primary production (NPP) is allocated into the different fuel types (grass, litter, twigs) using empirical based relationships. The model results are compared with field measurements of fuel load at a number of sites. The results will be used for modeling of biomass burning emissions.

Water, Energy, and Biogeochemical Budgets (WEBB) program: Data availability and research at the Northern Temperate Lakes site in north-central Wisconsin

USGS Publications Warehouse

Elder, John F.; Krabbenhoft, David P.; Walker, John F.

1992-01-01

The NTL-WEBB study area includes seven lakes that are also the site of a Long-Term Ecological Research (LTER) project, sponsored by the National Science Foundation. This project incorporates diverse research investigations conducted by faculty and research associates of the University of Wisconsin-Madison. The research orientation of NTL-LTER is principally toward aquatic ecology and geochemistry of the lakes. The WEBB research plan, with its emphasis on hydrologic processes in the lake watersheds, is designed to complement and enhance the LTER work.

Slow Lévy flights

NASA Astrophysics Data System (ADS)

Boyer, Denis; Pineda, Inti

2016-02-01

Among Markovian processes, the hallmark of Lévy flights is superdiffusion, or faster-than-Brownian dynamics. Here we show that Lévy laws, as well as Gaussian distributions, can also be the limit distributions of processes with long-range memory that exhibit very slow diffusion, logarithmic in time. These processes are path dependent and anomalous motion emerges from frequent relocations to already visited sites. We show how the central limit theorem is modified in this context, keeping the usual distinction between analytic and nonanalytic characteristic functions. A fluctuation-dissipation relation is also derived. Our results may have important applications in the study of animal and human displacements.

Neural Connectivity and Immunocytochemical Studies of Anatomical Sites Related to Nauseogenic and Emetic Reflexes

NASA Technical Reports Server (NTRS)

Fox, Robert A. (Principal Investigator)

1992-01-01

The studies conducted in this research project examined several aspects of neuroanatomical structures and neurochemical processes related to motion sickness in animal models. A principle objective of these studies was to investigate neurochemical changes in the central nervous system that are related to motion sickness with the objective of defining neural mechanisms important to this malady. For purposes of exposition, the studies and research finding have been classified into five categories. These are: immunoreactivity in the brainstem, vasopressin effects, lesion studies of area postrema, role of the vagus nerve, and central nervous system structure related to adaptation to microgravity.

Immediate propagation of deglacial environmental change to deep-marine turbidite systems along the Chile convergent margin

NASA Astrophysics Data System (ADS)

Bernhardt, Anne; Schwanghart, Wolfgang; Hebbeln, Dierk; Stuut, Jan-Berend W.; Strecker, Manfred R.

2017-09-01

Understanding how Earth-surface processes respond to past climatic perturbations is crucial for making informed predictions about future impacts of climate change on sediment fluxes. Sedimentary records provide the archives for inferring these processes, but their interpretation is compromised by our incomplete understanding of how sediment-routing systems respond to millennial-scale climate cycles. We analyzed seven sediment cores recovered from marine turbidite depositional sites along the Chile continental margin. The sites span a pronounced arid-to-humid gradient with variable relief and related sediment connectivity of terrestrial and marine environments. These sites allowed us to study event-related depositional processes in different climatic and geomorphic settings from the Last Glacial Maximum to the present day. The three sites reveal a steep decline of turbidite deposition during deglaciation. High rates of sea-level rise postdate the decline in turbidite deposition. Comparison with paleoclimate proxies documents that the spatio-temporal sedimentary pattern rather mirrors the deglacial humidity decrease and concomitant warming with no resolvable lag times. Our results let us infer that declining deglacial humidity decreased fluvial sediment supply. This signal propagated rapidly through the highly connected systems into the marine sink in north-central Chile. In contrast, in south-central Chile, connectivity between the Andean erosional zone and the fluvial transfer zone probably decreased abruptly by sediment trapping in piedmont lakes related to deglaciation, resulting in a sudden decrease of sediment supply to the ocean. Additionally, reduced moisture supply may have contributed to the rapid decline of turbidite deposition. These different causes result in similar depositional patterns in the marine sinks. We conclude that turbiditic strata may constitute reliable recorders of climate change across a wide range of climatic zones and geomorphic conditions. However, the underlying causes for similar signal manifestations in the sinks may differ, ranging from maintained high system connectivity to abrupt connectivity loss.

Biobanking sustainability--experiences of the Australian Breast Cancer Tissue Bank (ABCTB).

PubMed

Carpenter, Jane E; Clarke, Christine L

2014-12-01

Sustainability of biorepositories is a key issue globally. This article is a description of the different strategies and mechanisms used by the Australian Breast Cancer Tissue Bank (ABCTB) in developing and operating the resource since its inception in 2005. ABCTB operates according to a hub and spoke model, with a central management hub that is responsible for overall management of the resource including financial, ethical, and legal processes, researcher applications for material, clinical follow-up, information/database activities, and security. A centralized processing laboratory also operates from the hub site where DNA and RNA extractions are performed, digital imaging of stained tumor sections occurs, and specimens are assembled for dispatch for research projects. ABCTB collection sites where donors are identified, consent obtained, and specimens collected and processed for initial storage are located across Australia. Each of the activities of the resource requires financial support and different sources of revenue, some of which are allocated to a specific function of the ABCTB. Different models are in use at different collection centers where local variations may exist and local financial support may sometimes be obtained. There is also significant in-kind support by clinics and diagnostic and research facilities that house the various activities of the resource. However, long-term financial commitment to ensure the survival of the resource is not in place, and forward planning of operations remains challenging under these circumstances.

Economics of site preparation and release treatments using herbicides in Central Georgia

Treesearch

Rodney L. Busby; James H. Miller; M. Boyd Edwards

1998-01-01

Abstract. Land expectation values (LEV) of site preparation and release treatments using herbicides in central Georgia are calculated and compared Loblolly pine growth and hardwood competition levels were measured at age 6 for the site preparation treatments and age 8 for the release treatments. These measurements were projected to final harvest...

CPT site characterization for seismic hazards in the New Madrid seismic zone

USGS Publications Warehouse

Liao, T.; Mayne, P.W.; Tuttle, M.P.; Schweig, E.S.; Van Arsdale, R.B.

2002-01-01

A series of cone penetration tests (CPTs) were conducted in the vicinity of the New Madrid seismic zone in central USA for quantifying seismic hazards, obtaining geotechnical soil properties, and conducting studies at liquefaction sites related to the 1811-1812 and prehistoric New Madrid earthquakes. The seismic piezocone provides four independent measurements for delineating the stratigraphy, liquefaction potential, and site amplification parameters. At the same location, two independent assessments of soil liquefaction susceptibility can be made using both the normalized tip resistance (qc1N) and shear wave velocity (Vs1). In lieu of traditional deterministic approaches, the CPT data can be processed using probability curves to assess the level and likelihood of future liquefaction occurrence. ?? 2002 Elsevier Science Ltd. All rights reserved.

The COMPTEL Processing and Analysis Software system (COMPASS)

NASA Astrophysics Data System (ADS)

de Vries, C. P.; COMPTEL Collaboration

The data analysis system of the gamma-ray Compton Telescope (COMPTEL) onboard the Compton-GRO spacecraft is described. A continous stream of data of the order of 1 kbytes per second is generated by the instrument. The data processing and analysis software is build around a relational database managment system (RDBMS) in order to be able to trace heritage and processing status of all data in the processing pipeline. Four institutes cooperate in this effort requiring procedures to keep local RDBMS contents identical between the sites and swift exchange of data using network facilities. Lately, there has been a gradual move of the system from central processing facilities towards clusters of workstations.

An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing

PubMed Central

Troup, Lucy J.; Bastidas, Stephanie; Nguyen, Maia T.; Andrzejewski, Jeremy A.; Bowers, Matthew; Nomi, Jason S.

2016-01-01

The effect of cannabis on emotional processing was investigated using event-related potential paradigms (ERPs). ERPs associated with emotional processing of cannabis users, and non-using controls, were recorded and compared during an implicit and explicit emotional expression recognition and empathy task. Comparisons in P3 component mean amplitudes were made between cannabis users and controls. Results showed a significant decrease in the P3 amplitude in cannabis users compared to controls. Specifically, cannabis users showed reduced P3 amplitudes for implicit compared to explicit processing over centro-parietal sites which reversed, and was enhanced, at fronto-central sites. Cannabis users also showed a decreased P3 to happy faces, with an increase to angry faces, compared to controls. These effects appear to increase with those participants that self-reported the highest levels of cannabis consumption. Those cannabis users with the greatest consumption rates showed the largest P3 deficits for explicit processing and negative emotions. These data suggest that there is a complex relationship between cannabis consumption and emotion processing that appears to be modulated by attention. PMID:26926868

Hydrogeophysical Cyberinfrastructure For Real-Time Interactive Browser Controlled Monitoring Of Near Surface Hydrology: Results Of A 13 Month Monitoring Effort At The Hanford 300 Area

NASA Astrophysics Data System (ADS)

Versteeg, R. J.; Johnson, T.; Henrie, A.; Johnson, D.

2013-12-01

The Hanford 300 Area, located adjacent to the Columbia River in south-central Washington, USA, is the site of former research and uranium fuel rod fabrication facilities. Waste disposal practices at the site included discharging between 33 and 59 metric tons of uranium over a 40 year period into shallow infiltration galleries, resulting in persistent uranium contamination within the vadose and saturated zones. Uranium transport from the vadose zone to the saturated zone is intimately linked with water table fluctuations and river water driven by upstream dam operations. Different remedial efforts have occurred at the site to address uranium contamination. Numerous investigations are occurring at the site, both to investigate remedial performance and to increase the understanding of uranium dynamics. Several of these studies include acquisition of large hydrological and time lapse electrical geophysical data sets. Such datasets contain large amounts of information on hydrological processes. There are substantial challenges in how to effectively deal with the data volumes of such datasets, how to process such datasets and how to provide users with the ability to effectively access and synergize the hydrological information contained in raw and processed data. These challenges motivated the development of a cloud based cyberinfrastructure for dealing with large electrical hydrogeophysical datasets. This cyberinfrastructure is modular and extensible and includes datamanagement, data processing, visualization and result mining capabilities. Specifically, it provides for data transmission to a central server, data parsing in a relational database and processing of the data using a PNNL developed parallel inversion code on either dedicated or commodity compute clusters. Access to results is done through a browser with interactive tools allowing for generation of on demand visualization of the inversion results as well as interactive data mining and statistical calculation. This infrastructure was used for the acquisition and processing of an electrical geophysical timelapse survey which was collected over a highly instrumented field site in the Hanford 300 Area. Over a 13 month period between November 2011 and December 2012 1823 timelapse datasets were collected (roughly 5 datasets a day for a total of 23 million individual measurements) on three parallel resistivity lines of 30 m each with 0.5 meter electrode spacing. In addition, hydrological and environmental data were collected from dedicated and general purpose sensors. This dataset contains rich information on near surface processes on a range of different spatial and temporal scales (ranging from hourly to seasonal). We will show how this cyberinfrastructure was used to manage and process this dataset and how the cyberinfrastructure can be used to access, mine and visualize the resulting data and information.

Atrazine retention and degradation in the vadose zone at a till plain site in central Indiana

USGS Publications Warehouse

Bayless, E.R.

2001-01-01

The vadose zone was examined as an environmental compartment where significant quantities of atrazine and its degradation compounds may be stored and transformed. The vadose zone was targeted because regional studies in the White River Basin indicated a large discrepancy between the mass of atrazine applied to fields and the amount of the pesticide and its degradation compounds that are measured in ground and surface water. A study site was established in a rotationally cropped field in the till plain of central Indiana. Data were gathered during the 1994 growing season to characterize the site hydrogeology and the distribution of atrazine, desethylatrazine, deisopropylatrazine, didealkylatrazine and hydroxyatrazine in runoff, pore water, and ground water. The data indicated that atrazine and its degradation compounds were transported from land surface to a depth of 1.5 m within 60 days of application, but were undetected in the saturated zone at nearby monitoring wells. A numerical model was developed, based on the field data, to provide information about processes that could retain and degrade atrazine in the vadose zone. Simulations indicated that evapotranspiration is responsible for surface directed soil-moisture flow during much of the growing season. This process causes retention and degradation of atrazine in the vadose zone. Increased residence time in the vadose zone leads to nearly complete transformation of atrazine and its degradation products to unquantified degradation compounds. As a result of mascropore flow, small quantities of atrazine and its degradation compounds may reach the saturated zone.

CARETS: A prototype regional environmental information system. Volume 12: User evaluation of experimental land use maps and related products from the central Atlantic test site

NASA Technical Reports Server (NTRS)

Alexander, R. H. (Principal Investigator); Mcginty, H. K., III

1975-01-01

The author has identified the following significant results. Recommendations resulting from the CARETS evaluation reflect the need to establish a flexible and reliable system for providing more detailed raw and processed land resource information as well as the need to improve the methods of making information available to users.

Vision into Reality: Planning and Budgeting Processes Implemented at NMSU-Carlsbad through the Year 2000.

ERIC Educational Resources Information Center

Cowen, Sonia S.

Prepared for a site visit by the North Central Association (NCA), this report describes the goals and vision of New Mexico State University's two-year branch campus at Carlsbad (NMSU-C) through the year 2000. The first section states the mission, goals, and purposes of NMSU-C, while the second describes six campus-wide initiatives to be completed…

Landscape-and regional-scale shifts in forest composition under climate change in the Central Hardwood Region of the United States

Treesearch

Wen J. Wang; Hong S. He; Frank R. Thompson; Jacob S. Fraser; William D. Dijak

2016-01-01

Tree species distribution and abundance are affected by forces operating at multiple scales. Niche and biophysical process models have been commonly used to predict climate change effects at regional scales, however, these models have limited capability to include site-scale population dynamics and landscape- scale disturbance and dispersal. We applied a landscape...

Information Processing Research.

DTIC Science & Technology

1988-05-01

concentrated mainly on the Hitech chess machine, which achieves its success from parallelism in the right places. Hitech has now reached a National rating...includes local user workstations, a set of central server workstations each acting as a host for a Warp machine, and a few Warp multiprocessors. The... successful completion. A quorum for an operation is any such set of sites. Neces- sary and sufficient constraints on quorum intersections are derived

32 CFR Appendix C to Part 68 - Addendum for Education Services Between [Name of Educational Institution] and the U.S. Army

Code of Federal Regulations, 2014 CFR

2014-07-01

... processes. GoArmyEd is the Army Continuing Education System (ACES) centralized and streamlined management... and ACES remain in place and should be supplemented with DoD Instruction 1322.25. (3) Agree to all of the terms in the ACES policies and procedures, available athttps://www.hrc.army.mil/site/education/Go...

Linking Research and Practice in New York: A New York City Small Schools of Choice Case Study

ERIC Educational Resources Information Center

Hughes, Robert; Silver, David; Thompson, Saskia; Unterman, Rebecca

2012-01-01

Over the last decade, New York City (NYC) has been the site of a systemwide high school reform effort that is unprecedented in its scope and pace. Since 2002, the school district has closed more than 20 failing high schools, opened more than 200 new secondary schools, and implemented a centralized high school admission process in which…

Microenvironment Tracker (MicroTrac)

EPA Science Inventory

Epidemiologic studies have shown associations between air pollution concentrations measured at central-site ambient monitors and adverse health outcomes. Using central-site concentrations as exposure surrogates, however, can lead to exposure errors due to time spent in various in...

Discrete breathers for a discrete nonlinear Schrödinger ring coupled to a central site.

PubMed

Jason, Peter; Johansson, Magnus

2016-01-01

We examine the existence and properties of certain discrete breathers for a discrete nonlinear Schrödinger model where all but one site are placed in a ring and coupled to the additional central site. The discrete breathers we focus on are stationary solutions mainly localized on one or a few of the ring sites and possibly also the central site. By numerical methods, we trace out and study the continuous families the discrete breathers belong to. Our main result is the discovery of a split bifurcation at a critical value of the coupling between neighboring ring sites. Below this critical value, families form closed loops in a certain parameter space, implying that discrete breathers with and without central-site occupation belong to the same family. Above the split bifurcation the families split up into several separate ones, which bifurcate with solutions with constant ring amplitudes. For symmetry reasons, the families have different properties below the split bifurcation for even and odd numbers of sites. It is also determined under which conditions the discrete breathers are linearly stable. The dynamics of some simpler initial conditions that approximate the discrete breathers are also studied and the parameter regimes where the dynamics remain localized close to the initially excited ring site are related to the linear stability of the exact discrete breathers.

KSC-04PD-0259

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. U.S. Representative Ric Keller (left) listens intently to a presentation proposing the use of the Central Florida Research Park, near Orlando, as the site of NASAs new Shared Services Center. NASA and Florida officials toured the research park as well. Central Florida leaders are proposing the research park as the site for the center, which would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

When does word frequency influence written production?

PubMed

Baus, Cristina; Strijkers, Kristof; Costa, Albert

2013-01-01

The aim of the present study was to explore the central (e.g., lexical processing) and peripheral processes (motor preparation and execution) underlying word production during typewriting. To do so, we tested non-professional typers in a picture typing task while continuously recording EEG. Participants were instructed to write (by means of a standard keyboard) the corresponding name for a given picture. The lexical frequency of the words was manipulated: half of the picture names were of high-frequency while the remaining were of low-frequency. Different measures were obtained: (1) first keystroke latency and (2) keystroke latency of the subsequent letters and duration of the word. Moreover, ERPs locked to the onset of the picture presentation were analyzed to explore the temporal course of word frequency in typewriting. The results showed an effect of word frequency for the first keystroke latency but not for the duration of the word or the speed to which letter were typed (interstroke intervals). The electrophysiological results showed the expected ERP frequency effect at posterior sites: amplitudes for low-frequency words were more positive than those for high-frequency words. However, relative to previous evidence in the spoken modality, the frequency effect appeared in a later time-window. These results demonstrate two marked differences in the processing dynamics underpinning typing compared to speaking: First, central processing dynamics between speaking and typing differ already in the manner that words are accessed; second, central processing differences in typing, unlike speaking, do not cascade to peripheral processes involved in response execution.

When does word frequency influence written production?

PubMed Central

Baus, Cristina; Strijkers, Kristof; Costa, Albert

2013-01-01

The aim of the present study was to explore the central (e.g., lexical processing) and peripheral processes (motor preparation and execution) underlying word production during typewriting. To do so, we tested non-professional typers in a picture typing task while continuously recording EEG. Participants were instructed to write (by means of a standard keyboard) the corresponding name for a given picture. The lexical frequency of the words was manipulated: half of the picture names were of high-frequency while the remaining were of low-frequency. Different measures were obtained: (1) first keystroke latency and (2) keystroke latency of the subsequent letters and duration of the word. Moreover, ERPs locked to the onset of the picture presentation were analyzed to explore the temporal course of word frequency in typewriting. The results showed an effect of word frequency for the first keystroke latency but not for the duration of the word or the speed to which letter were typed (interstroke intervals). The electrophysiological results showed the expected ERP frequency effect at posterior sites: amplitudes for low-frequency words were more positive than those for high-frequency words. However, relative to previous evidence in the spoken modality, the frequency effect appeared in a later time-window. These results demonstrate two marked differences in the processing dynamics underpinning typing compared to speaking: First, central processing dynamics between speaking and typing differ already in the manner that words are accessed; second, central processing differences in typing, unlike speaking, do not cascade to peripheral processes involved in response execution. PMID:24399980

Temperature of upland and peatland soils in a north central Minnesota forest

Treesearch

Dale S. Nichols

1998-01-01

Soil temperature strongly influences physical, chemical, and biological activities in soil. However, soil temperature data for forest landscapes are scarce. For 6 yr, weekly soil temperatures were measured at two upland and four peatland sites in north central Minnesota. One upland site supported mature aspen forest, the other supported short grass. One peatland site...

Eco-physiology of Acer saccharum trees on glade-like sites in central Missouri

Treesearch

Eric J. Rhodenbaugh; Stephen G. Pallardy

1993-01-01

Although sugar maple (Acer saccharum Marsh.) is not considered drought tolerant, it is common on xeric limestone glade-like sites in central Missouri. Acer saccharum on such sites may be a drought-tolerant ecotype or may have access to deep water supply through bedrock cracks. We investigated these possibilities during the 1990...

A 13-WEEK COMPARISON OF PASSIVE AND CONTINUOUS OZONE MONITORS AT FORESTED SITES IN NORTH-CENTRAL PENNSYLVANIA

EPA Science Inventory

Ogawa passive 03 samplers were used in a 13-233k study (June 1-September 1, 1999) involving 11 forested and mountaintop sites in north-central Pennsylvania. Four of the sites were collocated with TECO model 49 O3 analyzers. A significant correlation (p<0.0001) was found for 2...

Prediction of future methane emission from irrigated rice paddies in central Thailand under different water management practices.

PubMed

Minamikawa, Kazunori; Fumoto, Tamon; Iizumi, Toshichika; Cha-Un, Nittaya; Pimple, Uday; Nishimori, Motoki; Ishigooka, Yasushi; Kuwagata, Tsuneo

2016-10-01

There is concern about positive feedbacks between climate change and methane (CH4) emission from rice paddies. However, appropriate water management may mitigate the problem. We tested this hypothesis at six field sites in central Thailand, where the irrigated area is rapidly increasing. We used DNDC-Rice, a process-based biogeochemistry model adjusted based on rice growth data at each site to simulate CH4 emission from a rice-rice double cropping system from 2001 to 2060. Future climate change scenarios consisting of four representative concentration pathways (RCPs) and seven global climate models were generated by statistical downscaling. We then simulated CH4 emission in three water management practices: continuous flooding (CF), single aeration (SA), and multiple aeration (MA). The adjusted model reproduced the observed rice yield and CH4 emission well at each site. The simulated CH4 emissions in CF from 2051 to 2060 were 5.3 to 7.8%, 9.6 to 16.0%, 7.3 to 18.0%, and 13.6 to 19.0% higher than those from 2001 to 2010 in RCPs 2.6, 4.5, 6.0, and 8.5, respectively, at the six sites. Regionally, SA and MA mitigated CH4 emission by 21.9 to 22.9% and 53.5 to 55.2%, respectively, relative to CF among the four RCPs. These mitigation potentials by SA and MA were comparable to those from 2001 to 2010. Our results indicate that climate change in the next several decades will not attenuate the quantitative effect of water management practices on mitigating CH4 emission from irrigated rice paddies in central Thailand. Copyright © 2016 Elsevier B.V. All rights reserved.

Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.

PubMed

Yano, Kanako; Yanagisawa, Takahiro; Mukae, Kyosuke; Niwa, Yasuo; Inoue, Yuko; Moriyasu, Yuji

2015-01-01

Tobacco BY-2 cells undergo autophagy in sucrose-free culture medium, which is the process mostly responsible for intracellular protein degradation under these conditions. Autophagy was inhibited by the vacuolar H(+)-ATPase inhibitors concanamycin A and bafilomycin A1, which caused the accumulation of autophagic bodies in the central vacuoles. Such accumulation did not occur in the presence of the autophagy inhibitor 3-methyladenine, and concanamycin in turn inhibited the accumulation of autolysosomes in the presence of the cysteine protease inhibitor E-64c. Electron microscopy revealed not only that the autophagic bodies were accumulated in the central vacuole, but also that autophagosome-like structures were more frequently observed in the cytoplasm in treatments with concanamycin, suggesting that concanamycin affects the morphology of autophagosomes in addition to raising the pH of the central vacuole. Using BY-2 cells that constitutively express a fusion protein of autophagosome marker protein Atg8 and green fluorescent protein (GFP), we observed the appearance of autophagosomes by fluorescence microscopy, which is a reliable morphological marker of autophagy, and the processing of the fusion protein to GFP, which is a biochemical marker of autophagy. Together, these results suggest the involvement of vacuole type H(+)-ATPase in the maturation step of autophagosomes to autolysosomes in the autophagic process of BY-2 cells. The accumulation of autophagic bodies in the central vacuole by concanamycin is a marker of the occurrence of autophagy; however, it does not necessarily mean that the central vacuole is the site of cytoplasm degradation.

Estimates of ground-water recharge rates for two small basins in central Nevada

USGS Publications Warehouse

Lichty, R.W.; McKinley, P.W.

1995-01-01

Estimates of ground-water recharge rates developed from hydrologic modeling studies are presented for 3-Springs and East Stewart basins. two small basins (analog sites) located in central Nevada. The analog-site studies were conducted to aid in the estimation of recharge to the paleohydrologic regime associated with ground water in the vicinity of Yucca Mountain under wetter climatic conditions. The two analog sites are located to the north and at higher elevations than Yucca Mountain, and the prevailing (current) climatic conditions at these sites is thought to be representative of the possible range of paleoclimatic conditions in the general area of Yucca Mountain during the Quaternary. Two independent modeling approaches were conducted at each of the analog sites using observed hydrologic data on precipitation, temperature, solar radiation stream discharge, and chloride-ion water chemistry for a 6-year study period (October 1986 through September 1992). Both models quantify the hydrologic water-balance equation and yield estimates of ground-water recharge, given appropriate input data. The first model uses a traditional approach to quantify watershed hydrology through a precipitation-runoff modeling system that accounts for the spatial variability of hydrologic inputs, processes, and responses (outputs) using a dailycomputational time step. The second model is based on the conservative nature of the dissolved chloride ion in selected hydrologic environments, and its use as a natural tracer allows the computation of acoupled, water and chloride-ion, mass-balance system of equations to estimate available water (sum ofsurface runoff and groundwater recharge). Results of the modeling approaches support the conclusion that reasonable estimates of average-annual recharge to ground water range from about 1 to 3 centimeters per year for 3-Springs basin (the drier site), and from about 30 to 32 centimeters per year for East Stewart basin (the wetter site). The most reliable results are those derived from a reduced form of the chloride-ion model because they reflect integrated, basinwide processes in terms of only three measured variables: precipitation amount, precipitation chemistry, and streamflow chemistry.

Classification and evaluation for forest sites on the Mid-Cumberland Plateau

Treesearch

Glendon W. Smalley

1982-01-01

Presents a comprehensive forest site classification system for the central portion of the Cumberland Plateau in northeast Alabama, and east-central Tennessee. The system is based on physiography, geology, soils, topography, and vegetation.

NASA Integrated Space Communications Network

NASA Technical Reports Server (NTRS)

Tai, Wallace; Wright, Nate; Prior, Mike; Bhasin, Kul

2012-01-01

The NASA Integrated Network for Space Communications and Navigation (SCaN) has been in the definition phase since 2010. It is intended to integrate NASA s three existing network elements, i.e., the Space Network, Near Earth Network, and Deep Space Network, into a single network. In addition to the technical merits, the primary purpose of the Integrated Network is to achieve a level of operating cost efficiency significantly higher than it is today. Salient features of the Integrated Network include (a) a central system element that performs service management functions and user mission interfaces for service requests; (b) a set of common service execution equipment deployed at the all stations that provides return, forward, and radiometric data processing and delivery capabilities; (c) the network monitor and control operations for the entire integrated network are conducted remotely and centrally at a prime-shift site and rotating among three sites globally (a follow-the-sun approach); (d) the common network monitor and control software deployed at all three network elements that supports the follow-the-sun operations.

Evaluation of airborne thermal infrared imagery for locating mine drainage sites in the Lower Kettle Creek and Cooks Run Basins, Pennsylvania, USA

USGS Publications Warehouse

Sams, James I.; Veloski, Garret

2003-01-01

High-resolution airborne thermal infrared (TIR) imagery data were collected over 90.6 km2 (35 mi2) of remote and rugged terrain in the Kettle Creek and Cooks Run Basins, tributaries of the West Branch of the Susquehanna River in north-central Pennsylvania. The purpose of this investigation was to evaluate the effectiveness of TIR for identifying sources of acid mine drainage (AMD) associated with abandoned coal mines. Coal mining from the late 1800s resulted in many AMD sources from abandoned mines in the area. However, very little detailed mine information was available, particularly on the source locations of AMD sites. Potential AMD sources were extracted from airborne TIR data employing custom image processing algorithms and GIS data analysis. Based on field reconnaissance of 103 TIR anomalies, 53 sites (51%) were classified as AMD. The AMD sources had low pH (<4) and elevated concentrations of iron and aluminum. Of the 53 sites, approximately 26 sites could be correlated with sites previously documented as AMD. The other 27 mine discharges identified in the TIR data were previously undocumented. This paper presents a summary of the procedures used to process the TIR data and extract potential mine drainage sites, methods used for field reconnaissance and verification of TIR data, and a brief summary of water-quality data.

Differential gene expression revealed with RNA-Seq and parallel genotype selection of the ornithine decarboxylase gene in fish inhabiting polluted areas.

PubMed

Vega-Retter, C; Rojas-Hernandez, N; Vila, I; Espejo, R; Loyola, D E; Copaja, S; Briones, M; Nolte, A W; Véliz, D

2018-03-19

How organisms adapt to unfavorable environmental conditions by means of plasticity or selection of favorable genetic variants is a central issue in evolutionary biology. In the Maipo River basin, the fish Basilichthys microlepidotus inhabits polluted and non-polluted areas. Previous studies have suggested that directional selection drives genomic divergence between these areas in 4% of Amplified Fragment Length Polymorphism (AFLP) loci, but the underlying genes and functions remain unknown. We hypothesized that B. microlepidotus in this basin has plastic and/or genetic responses to these conditions. Using RNA-Seq, we identified differentially expressed genes in individuals from two polluted sites compared with fish inhabiting non-polluted sites. In one polluted site, the main upregulated genes were related to cellular proliferation as well as suppression and progression of tumors, while biological processes and molecular functions involved in apoptotic processes were overrepresented in the upregulated genes of the second polluted site. The ornithine decarboxylase gene (related to tumor promotion and progression), which was overexpressed in both polluted sites, was sequenced, and a parallel pattern of a heterozygote deficiency and increase of the same homozygote genotype in both polluted sites compared with fish inhabiting the non-polluted sites was detected. These results suggest the occurrence of both a plastic response in gene expression and an interplay between phenotypic change and genotypic selection in the face of anthropogenic pollution.

Cyclic flank-vent and central-vent eruption patterns

NASA Astrophysics Data System (ADS)

Takada, Akira

Many basaltic and andesitic polygenetic volcanoes have cyclic eruptive activity that alternates between a phase dominated by flank eruptions and a phase dominated by eruptions from a central vent. This paper proposes the use of time-series diagrams of eruption sites on each polygenetic volcano and intrusion distances of dikes to evaluate volcano growth, to qualitatively reconstruct the stress history within the volcano, and to predict the next eruption site. In these diagrams the position of an eruption site is represented by the distance from the center of the volcano and the clockwise azimuth from north. Time-series diagrams of Mauna Loa, Kilauea, Kliuchevskoi, Etna, Sakurajima, Fuji, Izu-Oshima, and Hekla volcanoes indicate that fissure eruption sites of these volcanoes migrated toward the center of the volcano linearly, radially, or spirally with damped oscillation, occasionally forming a hierarchy in convergence-related features. At Krafla, terminations of dikes also migrated toward the center of the volcano with time. Eruption sites of Piton de la Fournaise did not converge but oscillated around the center. After the convergence of eruption sites with time, the central eruption phase is started. The intrusion sequence of dikes is modeled, applying crack interaction theory. Variation in convergence patterns is governed by the regional stress and the magma supply. Under the condition that a balance between regional extension and magma supply is maintained, the central vent convergence time during the flank eruption phase is 1-10 years, whereas the flank vent recurrence time during the central eruption phase is greater than 100 years owing to an inferred decrease in magma supply. Under the condition that magma supply prevails over regional extension, the central vent convergence time increases, whereas the flank vent recurrence time decreases owing to inferred stress relaxation. Earthquakes of M>=6 near a volcano during the flank eruption phase extend the central vent convergence time. Earthquakes during the central eruption phase promote recurrence of flank eruptions. Asymmetric distribution of eruption sites around the flanks of a volcano can be caused by local stress sources such as an adjacent volcano.

The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia.

PubMed

Sprick, Justin D; Soller, Babs R; Rickards, Caroline A

2016-11-01

Muscle tissue oxygenation (SmO 2 ) can track central blood volume loss associated with hemorrhage. Traditional peripheral measurement sites (e.g., forearm) may not be practical due to excessive movement or injury (e.g., amputation). The aim of this study was to evaluate the efficacy of three novel anatomical sites for the assessment of SmO 2 under progressive central hypovolemia. 10 male volunteers were exposed to stepwise prone lower body negative pressure to decrease central blood volume, while SmO 2 was assessed at four sites-the traditional site of the flexor carpi ulnaris (ARM), and three novel sites not previously investigated during lower body negative pressure, the deltoid, latissimus dorsi, and trapezius. SmO 2 at the novel sites was compared to the ARM sensor and to stroke volume responses. A reduction in SmO 2 was detected by the ARM sensor at the first level of lower body negative pressure (-15 mmHg; P = 0.007), and at -30 (the deltoid), -45 (latissimus dorsi), and -60 mmHg lower body negative pressure (trapezius) at the novel sites (P ≤ 0.04). SmO 2 responses at all novel sites were correlated with responses at the ARM (R ≥ 0.89), and tracked the reduction in stroke volume (R ≥ 0.87); the latissimus dorsi site exhibited the strongest linear correlations (R ≥ 0.96). Of the novel sensor sites, the latissimus dorsi exhibited the strongest linear associations with SmO 2 at the ARM, and with reductions in central blood volume. These findings have important implications for detection of hemorrhage in austere environments (e.g., combat) when use of a peripheral sensor may not be ideal, and may facilitate incorporation of these sensors into uniforms. © 2016 by the Society for Experimental Biology and Medicine.

Cost, energy, global warming, eutrophication and local human health impacts of community water and sanitation service options.

PubMed

Schoen, Mary E; Xue, Xiaobo; Wood, Alison; Hawkins, Troy R; Garland, Jay; Ashbolt, Nicholas J

2017-02-01

We compared water and sanitation system options for a coastal community across selected sustainability metrics, including environmental impact (i.e., life cycle eutrophication potential, energy consumption, and global warming potential), equivalent annual cost, and local human health impact. We computed normalized metric scores, which we used to discuss the options' strengths and weaknesses, and conducted sensitivity analysis of the scores to changes in variable and uncertain input parameters. The alternative systems, which combined centralized drinking water with sanitation services based on the concepts of energy and nutrient recovery as well as on-site water reuse, had reduced environmental and local human health impacts and costs than the conventional, centralized option. Of the selected sustainability metrics, the greatest advantages of the alternative community water systems (compared to the conventional system) were in terms of local human health impact and eutrophication potential, despite large, outstanding uncertainties. Of the alternative options, the systems with on-site water reuse and energy recovery technologies had the least local human health impact; however, the cost of these options was highly variable and the energy consumption was comparable to on-site alternatives without water reuse or energy recovery, due to on-site reuse treatment. Future work should aim to reduce the uncertainty in the energy recovery process and explore the health risks associated with less costly, on-site water treatment options. Copyright © 2016 Elsevier Ltd. All rights reserved.

Losing function through wetland mitigation in central Pennsylvania, USA.

PubMed

Hoeltje, S M; Cole, C A

2007-03-01

In the United States, the Clean Water Act requires mitigation for wetlands that are negatively impacted by dredging and filling activities. During the mitigation process, there generally is little effort to assess function for mitigation sites and function is usually inferred based on vegetative cover and acreage. In our study, hydrogeomorphic (HGM) functional assessment models were used to compare predicted and potential levels of functional capacity in created and natural reference wetlands. HGM models assess potential function by measurement of a suite of structural variables and these modeled functions can then be compared to those in natural, reference wetlands. The created wetlands were built in a floodplain setting of a valley in central Pennsylvania to replace natural ridge-side slope wetlands. Functional assessment models indicated that the created sites differed significantly from natural wetlands that represented the impacted sites for seven of the ten functions assessed. This was expected because the created wetlands were located in a different geomorphic setting than the impacted sites, which would affect the type and degree of functions that occur. However, functional differences were still observed when the created sites were compared with a second set of reference wetlands that were located in a similar geomorphic setting (floodplain). Most of the differences observed in both comparisons were related to unnatural hydrologic regimes and to the characteristics of the surrounding landscape. As a result, the created wetlands are not fulfilling the criteria for successful wetland mitigation.

Classification and evaluation for forest sites on the Eastern Highland Rim and Pennyroyal.

Treesearch

Glendon W. Smalley

1983-01-01

Presents a comprehensive forest site classification system for the Eastern Highland Rim and Pennyroyal in north Alabama, east-central Tennessee, and central Kentucky. The system is based on physiography, geology, soils, topography, and vegetation.

Reliability of an fMRI Paradigm for Emotional Processing in a Multisite Longitudinal Study

PubMed Central

Gee, Dylan G.; McEwen, Sarah C.; Forsyth, Jennifer K.; Haut, Kristen M.; Bearden, Carrie E.; Addington, Jean; Goodyear, Bradley; Cadenhead, Kristin S.; Mirzakhanian, Heline; Cornblatt, Barbara A.; Olvet, Doreen; Mathalon, Daniel H.; McGlashan, Thomas H.; Perkins, Diana O.; Belger, Aysenil; Seidman, Larry J.; Thermenos, Heidi; Tsuang, Ming T.; van Erp, Theo G.M.; Walker, Elaine F.; Hamann, Stephan; Woods, Scott W.; Constable, Todd; Cannon, Tyrone D.

2015-01-01

Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala (Eρ2=0.82), inferior frontal gyrus (IFG;Eρ2=0.83), anterior cingulate cortex (ACC;Eρ2=0.76), insula (Eρ2=0.85), and fusiform gyrus (Eρ2=0.91) for maximum activation and fair to excellent reliability in the amygdala (Eρ2=0.44), IFG (Eρ2=0.48), ACC (Eρ2=0.55), insula (Eρ2=0.42), and fusiform gyrus (Eρ2=0.83) for mean activation across sites and test days. For the amygdala, habituation (Eρ2=0.71) was more stable than mean activation. In a second investigation, data from 111 healthy individuals across sites were aggregated in a voxelwise, quantitative meta-analysis. When compared with a mixed effects model controlling for site, both approaches identified robust activation in regions consistent with expected results based on prior single-site research. Overall, regions central to emotion processing showed strong reliability in the traveling participants study and robust activation in the aggregation study. These results support the reliability of blood oxygen level-dependent signal in emotion processing areas across different sites and scanners and may inform future efforts to increase efficiency and enhance knowledge of rare conditions in the population through multisite neuroimaging paradigms. PMID:25821147

Comparative analytical costs of central laboratory glucose and bedside glucose testing: a College of American Pathologists Q-Probes study.

PubMed

Howanitz, Peter J; Jones, Bruce A

2004-07-01

One of the major attributes of laboratory testing is cost. Although fully automated central laboratory glucose testing and semiautomated bedside glucose testing (BGT) are performed at most institutions, rigorous determinations of interinstitutional comparative costs have not been performed. To compare interinstitutional analytical costs of central laboratory glucose testing and BGT and to provide suggestions for improvement. Participants completed a demographic form about their institutional glucose monitoring practices. They also collected information about the costs of central laboratory glucose testing, BGT at a high-volume testing site, and BGT at a low-volume testing site, including specified cost variables for labor, reagents, and instruments. A total of 445 institutions enrolled in the College of American Pathologists Q-Probes program. Median cost per glucose test at 3 testing sites. The median (10th-90th percentile range) costs per glucose test were 1.18 dollars (5.59 dollars-0.36 dollars), 1.96 dollars (9.51 dollars-0.77 dollars), and 4.66 dollars (27.54 dollars-1.02 dollars) for central laboratory, high-volume BGT sites, and low-volume BGT sites, respectively. The largest percentages of the cost per test were for labor (59.3%, 72.7%, and 85.8%), followed by supplies (27.2%, 27.3%, and 13.4%) and equipment (2.1%, 0.0%, and 0.0%) for the 3 sites, respectively. The median number of patient specimens per month at the high-volume BGT sites was 625 compared to 30 at the low-volume BGT sites. Most participants did not include labor, instrument maintenance, competency assessment, or oversight in their BGT estimated costs until required to do so for the study. Analytical costs per glucose test were lower for central laboratory glucose testing than for BGT, which, in turn, was highly variable and dependent on volume. Data that would be used for financial justification for BGT were widely aberrant and in need of improvement.

Temporal changes in aquatic-invertebrate and fish assemblages in streams of the north-central and northeastern U.S.

USGS Publications Warehouse

Kennen, Jonathan G.; Sullivan, Daniel J.; May, Jason T.; Bell, Amanda H.; Beaulieu, Karen M.; Rice, Donald E.

2012-01-01

Many management agencies seek to evaluate temporal changes in aquatic assemblages at monitoring sites, but few have sites with ecological time series that are long enough for this purpose. Trends in aquatic-invertebrate and fish assemblage composition were assessed at 27 long-term monitoring sites in the north-central and northeastern United States. Temporal changes were identified using serial trend analysis. Sites with significant serial trends were further evaluated by relating explanatory environmental variables (e.g., streamflow, habitat, and water chemistry) to changes in assemblage composition. Significant trends were found at 19 of 27 study sites; however, differences in the sensitivity of the aquatic fauna to environmental stressors were identified. For example, significant trends in fish assemblages were found at more sites (15 of 27) than for aquatic-invertebrate assemblages (10 of 27 sites). In addition, trends in the invertebrate assemblage were most often explained by changes in streamflow processes (e.g., duration and magnitude of low- and high-flows, streamflow variability, and annual rates of change), whereas trends in the fish assemblage were more related to changes in water chemistry. Results illustrate the value of long-term monitoring for the purpose of assessing temporal trends in aquatic assemblages. The ability to detect trends in assemblage composition and to attribute these changes to environmental factors is necessary to understand mechanistic pathways and to further our understanding of how incremental anthropogenic alterations modify aquatic assemblages over time. Finally, this study's approach to trends analysis can be used to better inform the design of monitoring programs as well as support the ongoing management needs of stakeholders, water-resource agencies, and policy makers.

Thirty thousand-year-old evidence of plant food processing

PubMed Central

Revedin, Anna; Aranguren, Biancamaria; Becattini, Roberto; Longo, Laura; Marconi, Emanuele; Lippi, Marta Mariotti; Skakun, Natalia; Sinitsyn, Andrey; Spiridonova, Elena; Svoboda, Jiří

2010-01-01

European Paleolithic subsistence is assumed to have been largely based on animal protein and fat, whereas evidence for plant consumption is rare. We present evidence of starch grains from various wild plants on the surfaces of grinding tools at the sites of Bilancino II (Italy), Kostenki 16–Uglyanka (Russia), and Pavlov VI (Czech Republic). The samples originate from a variety of geographical and environmental contexts, ranging from northeastern Europe to the central Mediterranean, and dated to the Mid-Upper Paleolithic (Gravettian and Gorodtsovian). The three sites suggest that vegetal food processing, and possibly the production of flour, was a common practice, widespread across Europe from at least ~30,000 y ago. It is likely that high energy content plant foods were available and were used as components of the food economy of these mobile hunter–gatherers. PMID:20956317

Salt efflorescence due to water-rock interaction on the surface of tuff cave in the Yoshimi-Hyakuana Historic Site, central Japan

NASA Astrophysics Data System (ADS)

Oguchi, Chiaki T.; Kodama, Shogo; Mohammad, Rajib; Tharanga Udagedara, Dashan

2016-04-01

Artificial cave walls in Yoshimi Hyakuana Historic Site have been suffering from salt weathering since 1945 when the caves were made. To consider the processes of weathering and subsequent crystallization of secondary minerals, water-rock experiment using tuff from this area was performed. Rocks, surface altered materials, groundwater and rainwater were collected, and chemical and mineralogical characteristics of those samples were investigated. The XRD and SEM-EDS analyses were carried out for the solid samples and ICP-OES analysis was performed for the solution generated from the experiment, groundwater and rainwater. Gypsum is detected in original tuff, and on grey and whiter coloured altered materials. General chemical changes were observed on this rock. However, it is found that purple and black altered materials were mainly made due to microbiological processes.

The NAIMS cooperative pilot project: Design, implementation and future directions.

PubMed

Oh, Jiwon; Bakshi, Rohit; Calabresi, Peter A; Crainiceanu, Ciprian; Henry, Roland G; Nair, Govind; Papinutto, Nico; Constable, R Todd; Reich, Daniel S; Pelletier, Daniel; Rooney, William; Schwartz, Daniel; Tagge, Ian; Shinohara, Russell T; Simon, Jack H; Sicotte, Nancy L

2017-10-01

The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability.

Central San Juan caldera cluster: Regional volcanic framework

USGS Publications Warehouse

Lipman, Peter W.

2000-01-01

Eruption of at least 8800 km3 of dacitic-rhyolitic magma as 9 major ash-slow sheets (individually 150-5000 km3) was accompanied by recurrent caldera subsidence between 28.3 and about 26.5 Ma in the central San Juan Mountains, Colorado. Voluminous andesitic-decitic lavas and breccias were erupted from central volcanoes prior to the ash-flow eruptions, and similar lava eruptions continued within and adjacent to the calderas during the period of explosive volcanism, making the central San Juan caldera cluster an exceptional site for study of caldera-related volcanic processes. Exposed calderas vary in size from 10 to 75 km in maximum diameter, the largest calderas being associated with the most voluminous eruptions. After collapse of the giant La Garita caldera during eruption if the Fish Canyon Tuff at 17.6 Ma, seven additional explosive eruptions and calderas formed inside the La Garita depression within about 1 m.y. Because of the nested geometry, maximum loci of recurrently overlapping collapse events are inferred to have subsided as much as 10-17 km, far deeper than the roof of the composite subvolcanic batholith defined by gravity data, which represents solidified caldera-related magma bodies. Erosional dissection to depths of as much as 1.5 km, although insufficient to reach the subvolcanic batholith, has exposed diverse features of intracaldera ash-flow tuff and interleaved caldera-collapse landslide deposits that accumulated to multikilometer thickness within concurrently subsiding caldera structures. The calderas display a variety of postcollapse resurgent uplift structures, and caldera-forming events produced complex fault geometries that localized late mineralization, including the epithermal base- and precious-metal veins of the well-known Creede mining district. Most of the central San Juan calderas have been deeply eroded, and their identification is dependent on detailed geologic mapping. In contrast, the primary volcanic morphology of the symmetrically resurgent Creede caldera, the volcanic framework for Lake Creede, has been exceptionally preserved because of rapid infilling by moat sediments of the Creede Formation, which were preferentially eroded during the past few million years. The ash-flow tuffs and caldera of the central San Juan region have been widely recognized as exceptional sites for study of explosive volcanic processes, and the results reported here provide new insights into processes of pyroclastic eruption and emplacement, geometric interrelations between caldera subsidence and resurgence, the petrologic diversity of sequential ash-flow eruptions, recurrent eruption of intermediate-composition lavas after each caldera-forming event, associated regional fault development, volume relations between ash-flow eruptions and associated calderas, the emplacement of subvolcanic batholiths, and involvement of mantle-derived mafic phases in magma-generation processes.

Transforming the High School Experience: How New York City's New Small Schools Are Boosting Student Achievement and Graduation Rates

ERIC Educational Resources Information Center

Bloom, Howard S.; Thompson, Saskia Levy; Unterman, Rebecca

2011-01-01

Over the last decade, New York City has been the site of a systemwide high school reform effort that is unprecedented in its scope and pace. Since 2002, the school district has closed more than 20 failing high schools, opened more than 200 new secondary schools, and implemented a centralized high school admission process in which approximately…

Productivity and cost of the ponsse 15-series, cust-to-length harvesting systems in southern pine plantations

Treesearch

Robert A. Tufts

1997-01-01

Machine productivity data were collected for a Ponsse HS-15 harvester and S-15 forwarder from study sites in central Alabama during a second thinning. Tree size, in terms of diameter at breast height and volume, and the number of pieces processed per tree, were the variables with the greatest impact on harvester productivity. The distance fiom the machine to the tree...

Using a process-based model (3-PG) to predict and map hybrid poplar biomass productivity in Minnesota and Wisconsin, USA

Treesearch

William L. Headlee; Ronald S. Jr. Zalesny; Deahn M. Donner; Richard B. Hall

2013-01-01

Hybrid poplars have demonstrated high biomass productivity in the North Central USA as short rotation woody crops (SRWCs). However, our ability to quantitatively predict productivity for sites that are not currently in SRWCs is limited. As a result, stakeholders are also limited in their ability to evaluate different areas within the region as potential supply sheds...

Managing data from multiple disciplines, scales, and sites to support synthesis and modeling

USGS Publications Warehouse

Olson, R. J.; Briggs, J. M.; Porter, J.H.; Mah, Grant R.; Stafford, S.G.

1999-01-01

The synthesis and modeling of ecological processes at multiple spatial and temporal scales involves bringing together and sharing data from numerous sources. This article describes a data and information system model that facilitates assembling, managing, and sharing diverse data from multiple disciplines, scales, and sites to support integrated ecological studies. Cross-site scientific-domain working groups coordinate the development of data associated with their particular scientific working group, including decisions about data requirements, data to be compiled, data formats, derived data products, and schedules across the sites. The Web-based data and information system consists of nodes for each working group plus a central node that provides data access, project information, data query, and other functionality. The approach incorporates scientists and computer experts in the working groups and provides incentives for individuals to submit documented data to the data and information system.

Geodynamic movements and deformations of the Sudetic structural unit of the Bohemian Massif

NASA Astrophysics Data System (ADS)

Schenk, V.; Jechumtálová, Z.; Schenková, Z.; Kottnauer, P.

2003-04-01

The African plate pushes to European orogenic Alpine structures that transfer the compression further to Variscan structural units, including the Bohemian Massif. Central parts of the Bohemian Massif are relatively deep-seated and, therefore, some of marginal parts of the Massif and its border geological structures should be affected intensively and moved distinctly with respect to the central parts. The geodynamical GPS network EAST SUDETEN is located just over the area mentioned above, i.e. it covers both kinetically quasi-effected and quasi-non-effected structural blocks. GPS data observed already for six annual campaigns (1997-2002) were processed and movement vectors of individual network sites were assessed. Applied data processing did not allow errors in the horizontal direction 2 mm and in the vertical direction 5-6 mm to be exceeded. Since time series of coordinate changes for several network sites gave rather pronounce movement trends, preliminary deformations among individual structural blocks were evaluated and compared to other geological, geophysical and geodetic materials. The investigation has been supported by the Grant Agency of the Czech Republic, projects 205/97/0679 and 205/01/0480, and by the research programme of the Ministry of Education, Youth and Sport of the Czech Republic, project LN00A005 "Dynamics of the Earth".

Singly applied herbicides for site preparation and release of loblolly pine in central Georgia

Treesearch

James H. Miller; M. Boyd Edwards

1995-01-01

Abstract.Separate studies were installed to evaluate site-preparation and release herbicide treatments for loblolly pine.(Pinus taeda L.).Tests were at four locations each on the Piedmont and Coastal Plain of central Georgia.

Eucalyptus Energy Farm: feasibility study and demonstration. Phase 1: site and species selection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mariani, E.O.; Wood, W.A.; Kouchoukos, P.C.

1978-06-01

The results of investigations to determine the feasibility for establishing ''Eucalyptus Energy Farms'' as a potential source of biomass derived energy are presented. Included in this report are: the results of an extensive literature search and numerous field interviews (both domestically and internationally) to identify those Eucalyptus species most suitable for use within the United States; a description of the site selection criteria, site selection process, and identification of potential sites for use in testing the Eucalyptus Energy Farm concept; a description of the Eucalyptus species selection criteria, species selection process, and an identification of the specific species recommended formore » testing at specific sites; preliminary engineering designs for each of the proposed plantation sites; and environmental impact considerations related to Eucalyptus growing. It is concluded that although the Eucalyptus are extremely temperature sensitive and the geographic areas which appear suitable for their planting (within the United States) are principally confined to western and central California and the warmest regions of the southeastern United States, each of the areas contain large amounts of marginal land which could be converted into Eucalyptus based biomass plantations. Suitable sites, which are representative of the larger marginal land areas, are immediately available for use in establishing Eucalyptus screening test sites. Furthermore, there are not significant environmental conditions which would preclude the establishment of these initial test sites. It is therefore recommended that efforts be initiated to obtain selected provenances of Eucalyptus seeds (of the designated species) for further field testing and data collection within the United States, and that actual site selection be initiated.« less

Precisely relocated seismicity using 3-D seismic velocity model by double-difference tomography method and orogenic processes in central and southern Taiwan

NASA Astrophysics Data System (ADS)

Nagai, S.; Wu, Y.; Suppe, J.; Hirata, N.

2009-12-01

The island of Taiwan is located in the site of ongoing arc-continent collision zone between the Philippine Sea Plate and the Eurasian Plate. Numerous geophysical and geological studies are done in and around Taiwan to develop various models to explain the tectonic processes in the Taiwan region. The active and young tectonics and the associated high seismicity in Taiwan provide us with unique opportunity to explore and understand the processes in the region related to the arc-continent collision. Nagai et al. [2009] imaged eastward dipping alternate high- and low-velocity bodies at depths of 5 to 25 km from the western side of the Central Mountain Range to the eastern part of Taiwan, by double-difference tomography [Zhang and Thurber, 2003] using three temporary seismic networks with the Central Weather Bureau Seismic Network(CWBSN). These three temporary networks are the aftershock observation after the 1999 Chi-Chi Taiwan earthquake and two dense linear array observations; one is across central Taiwan in 2001, another is across southern Taiwan in 2005, respectively. We proposed a new orogenic model, ’Upper Crustal Stacking Model’ inferred from our tomographic images. To understand the detailed seismic structure more, we carry on relocating earthquakes more precisely in central and southern Taiwan, using three-dimensional velocity model [Nagai et al., 2009] and P- and S-wave arrival times both from the CWBSN and three temporary networks. We use the double-difference tomography method to improve relative and absolute location accuracy simultaneously. The relocated seismicity is concentrated and limited along the parts of boundaries between low- and high-velocity bodies. Especially, earthquakes occurred beneath the Eastern Central Range, triggered by 1999 Chi-Chi earthquake, delineate subsurface structural boundaries, compared with profiles of estimated seismic velocity. The relocated catalog and 3-D seismic velocity model give us some constraints to reconstruct the orogenic model in Taiwan. We show these relocated seismicity with P- and S-wave velocity profiles, with focal mechanisms [e.g. Wu et al., 2008] and spatio-temporal variation, in central and southern Taiwan and discuss tectonic processes in Taiwan.

Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.

PubMed

Jacobsen, Jonathan Henry W; Watkins, Linda R; Hutchinson, Mark R

2014-01-01

Opioids have historically, and continue to be, an integral component of pain management. However, despite pharmacokinetic and dynamic optimization over the past 100 years, opioids continue to produce many undesirable side effects such as tolerance, reward, and dependence. As such, opioids are liable for addiction. Traditionally, opioid addiction was viewed as a solely neuronal process, and while substantial headway has been made into understanding the molecular and cellular mechanisms mediating this process, research has however, been relatively ambivalent to how the rest of the central nervous system (CNS) responds to opioids. Evidence over the past 20 years has clearly demonstrated the importance of the immunocompetent cells of the CNS (glia) in many aspects of opioid pharmacology. Particular focus has been placed on microglia and astrocytes, who in response to opioids, become activated and release inflammatory mediators. Importantly, the mechanism underlying immune activation is beginning to be elucidated. Evidence suggests an innate immune pattern-recognition receptor (toll-like receptor 4) as an integral component underlying opioid-induced glial activation. The subsequent proinflammatory response may be viewed akin to neurotransmission creating a process termed central immune signaling. Translationally, we are beginning to appreciate the importance of central immune signaling as it contributes to many behavioral actions of addiction including reward, withdrawal, and craving. As such, the aim of this chapter is to review and integrate the neuronal and central immune signaling perspective of addiction. © 2014 Elsevier Inc. All rights reserved.

MX Siting Investigation. MX System Siting Summary Report. General Introduction. Volume I. Part I.

DTIC Science & Technology

1982-01-18

Mountain Spring Peak 1972 Observation Knoll 1971 Pinto Spring 1971 Steamboat Mountain 1971 Steamboat Mountain SW 1971 The Tetons 1971 Zane 1972 MX SITING...Silver Peak 1978 Stoddard Mountain 1978 Water Creek Canyon 1972 Yale Crossing 1971 49 Beaver Dam Mountains NE 1955 Central East 1972 Central West 1972...SHELTER SITE -ORIGINAL ROAD --- RESITED ROAD *• = FOUND 3 1/2" BRASS CAP SET ON 2 1/2" IRON PIPE . U.S DEPARTMENT OF THE INTERIOR. BUREAU OF LAND

Novel Approaches for Estimating Human Exposure to Air Pollutants

EPA Science Inventory

Numerous health studies have used measurements from a few central-site ambient monitors to characterize air pollution exposures. Relying on solely on central-site ambient monitors does not account for the spatial-heterogeneity of ambient air pollution patterns, the temporal varia...

KENNEDY SPACE CENTER, FLA. - KSC Director Jim Kennedy makes a presentation to NASA and other officials about the benefits of locating NASA’s new Shared Services Center in the Central Florida Research Park, near Orlando. At the far left is Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - KSC Director Jim Kennedy makes a presentation to NASA and other officials about the benefits of locating NASA’s new Shared Services Center in the Central Florida Research Park, near Orlando. At the far left is Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Spatial and ecological variation in dryland ecohydrological responses to climate change: implications for management

USGS Publications Warehouse

Palmquist, Kyle A.; Schlaepfer, Daniel R.; Bradford, John B.; Lauenroth, William K.

2016-01-01

Ecohydrological responses to climate change will exhibit spatial variability and understanding the spatial pattern of ecological impacts is critical from a land management perspective. To quantify climate change impacts on spatial patterns of ecohydrology across shrub steppe ecosystems in North America, we asked the following question: How will climate change impacts on ecohydrology differ in magnitude and variability across climatic gradients, among three big sagebrush ecosystems (SB-Shrubland, SB-Steppe, SB-Montane), and among Sage-grouse Management Zones? We explored these potential changes for mid-century for RCP8.5 using a process-based water balance model (SOILWAT) for 898 big sagebrush sites using site- and scenario-specific inputs. We summarize changes in available soil water (ASW) and dry days, as these ecohydrological variables may be helpful in guiding land management decisions about where to geographically concentrate climate change mitigation and adaptation resources. Our results suggest that during spring, soils will be wetter in the future across the western United States, while soils will be drier in the summer. The magnitude of those predictions differed depending on geographic position and the ecosystem in question: Larger increases in mean daily spring ASW were expected for high-elevation SB-Montane sites and the eastern and central portions of our study area. The largest decreases in mean daily summer ASW were projected for warm, dry, mid-elevation SB-Montane sites in the central and west-central portions of our study area (decreases of up to 50%). Consistent with declining summer ASW, the number of dry days was projected to increase rangewide, but particularly for SB-Montane and SB-Steppe sites in the eastern and northern regions. Collectively, these results suggest that most sites will be drier in the future during the summer, but changes were especially large for mid- to high-elevation sites in the northern half of our study area. Drier summer conditions in high-elevation, SB-Montane sites may result in increased habitat suitability for big sagebrush, while those same changes will likely reduce habitat suitability for drier ecosystems. Our work has important implications for where land managers should prioritize resources for the conservation of North American shrub steppe plant communities and the species that depend on them.

Summary of suspended-sediment concentration data, San Francisco Bay, California, water year 2010

USGS Publications Warehouse

Buchanan, Paul A.; Morgan, Tara L.

2014-01-01

Suspended-sediment concentration data were collected by the U.S. Geological Survey in San Francisco Bay during water year 2010 (October 1, 2009–September 30, 2010). Turbidity sensors and water samples were used to monitor suspended-sediment concentration at two sites in Suisun Bay, one site in San Pablo Bay, three sites in Central San Francisco Bay, and one site in South San Francisco Bay. Sensors were positioned at two depths at most sites to help define the vertical variability of suspended sediments. Water samples were collected periodically and analyzed for concentrations of suspended sediment. The results of the analyses were used to calibrate the output of the turbidity sensors so that a record of suspended-sediment concentrations could be computed. This report presents the data-collection methods used and summarizes, in graphs, the suspended-sediment concentration data collected from October 2009 through September 2010. Calibration curves and plots of the processed data for each sensor also are presented.

Beneficial Effects of X-Irradiation on Recovery of lesioned Mammalian Central Nervous Tissue

NASA Astrophysics Data System (ADS)

Kalderon, Nurit; Alfieri, Alan A.; Fuks, Zvi

1990-12-01

We examined the potential of x-irradiation, at clinical dose levels, to manipulate the cellular constituents and thereby change the consequences of transection injury to adult mammalian central nervous tissue (rat olfactory bulb). Irradiation resulted in reduction or elimination of reactive astrocytes at the site of incision provided that it was delivered within a defined time window postinjury. Under conditions optimal for the elimination of gliosis (15-18 days postinjury), irradiation of severed olfactory bulbs averted some of the degenerative consequences of lesion. We observed that irradiation was accompanied by prevention of tissue degeneration around the site of lesion, structural healing with maintenance of the typical cell lamination, and rescue of some axotomized mitral cells (principal bulb neurons). Thus radiation resulted in partial preservation of normal tissue morphology. It is postulated that intrusive cell populations are generated in response to injury and reactive astrocytes are one such group. Our results suggest that selective elimination of these cells by irradiation enabled some of the regenerative processes that are necessary for full recovery to maintain their courses. The cellular targets of these cells, their modes of intervention in recovery, and the potential role of irradiation as a therapeutic modality for injured central nervous system are discussed.

A Process-based, Climate-Sensitive Model to Derive Methane Emissions from Natural Wetlands: Application to 5 Wetland Sites, Sensitivity to Model Parameters and Climate

NASA Technical Reports Server (NTRS)

Walter, Bernadette P.; Heimann, Martin

1999-01-01

Methane emissions from natural wetlands constitutes the largest methane source at present and depends highly on the climate. In order to investigate the response of methane emissions from natural wetlands to climate variations, a 1-dimensional process-based climate-sensitive model to derive methane emissions from natural wetlands is developed. In the model the processes leading to methane emission are simulated within a 1-dimensional soil column and the three different transport mechanisms diffusion, plant-mediated transport and ebullition are modeled explicitly. The model forcing consists of daily values of soil temperature, water table and Net Primary Productivity, and at permafrost sites the thaw depth is included. The methane model is tested using observational data obtained at 5 wetland sites located in North America, Europe and Central America, representing a large variety of environmental conditions. It can be shown that in most cases seasonal variations in methane emissions can be explained by the combined effect of changes in soil temperature and the position of the water table. Our results also show that a process-based approach is needed, because there is no simple relationship between these controlling factors and methane emissions that applies to a variety of wetland sites. The sensitivity of the model to the choice of key model parameters is tested and further sensitivity tests are performed to demonstrate how methane emissions from wetlands respond to climate variations.

Decentralized approaches to wastewater treatment and management: applicability in developing countries.

PubMed

Massoud, May A; Tarhini, Akram; Nasr, Joumana A

2009-01-01

Providing reliable and affordable wastewater treatment in rural areas is a challenge in many parts of the world, particularly in developing countries. The problems and limitations of the centralized approaches for wastewater treatment are progressively surfacing. Centralized wastewater collection and treatment systems are costly to build and operate, especially in areas with low population densities and dispersed households. Developing countries lack both the funding to construct centralized facilities and the technical expertise to manage and operate them. Alternatively, the decentralized approach for wastewater treatment which employs a combination of onsite and/or cluster systems is gaining more attention. Such an approach allows for flexibility in management, and simple as well as complex technologies are available. The decentralized system is not only a long-term solution for small communities but is more reliable and cost effective. This paper presents a review of the various decentralized approaches to wastewater treatment and management. A discussion as to their applicability in developing countries, primarily in rural areas, and challenges faced is emphasized all through the paper. While there are many impediments and challenges towards wastewater management in developing countries, these can be overcome by suitable planning and policy implementation. Understanding the receiving environment is crucial for technology selection and should be accomplished by conducting a comprehensive site evaluation process. Centralized management of the decentralized wastewater treatment systems is essential to ensure they are inspected and maintained regularly. Management strategies should be site specific accounting for social, cultural, environmental and economic conditions in the target area.

Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis*

PubMed Central

Yang, Mingkun; Wang, Yan; Chen, Ying; Cheng, Zhongyi; Gu, Jing; Deng, Jiaoyu; Bi, Lijun; Chen, Chuangbin; Mo, Ran; Wang, Xude; Ge, Feng

2015-01-01

Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, remains one of the most prevalent human pathogens and a major cause of mortality worldwide. Metabolic network is a central mediator and defining feature of the pathogenicity of Mtb. Increasing evidence suggests that lysine succinylation dynamically regulates enzymes in carbon metabolism in both bacteria and human cells; however, its extent and function in Mtb remain unexplored. Here, we performed a global succinylome analysis of the virulent Mtb strain H37Rv by using high accuracy nano-LC-MS/MS in combination with the enrichment of succinylated peptides from digested cell lysates and subsequent peptide identification. In total, 1545 lysine succinylation sites on 626 proteins were identified in this pathogen. The identified succinylated proteins are involved in various biological processes and a large proportion of the succinylation sites are present on proteins in the central metabolism pathway. Site-specific mutations showed that succinylation is a negative regulatory modification on the enzymatic activity of acetyl-CoA synthetase. Molecular dynamics simulations demonstrated that succinylation affects the conformational stability of acetyl-CoA synthetase, which is critical for its enzymatic activity. Further functional studies showed that CobB, a sirtuin-like deacetylase in Mtb, functions as a desuccinylase of acetyl-CoA synthetase in in vitro assays. Together, our findings reveal widespread roles for lysine succinylation in regulating metabolism and diverse processes in Mtb. Our data provide a rich resource for functional analyses of lysine succinylation and facilitate the dissection of metabolic networks in this life-threatening pathogen. PMID:25605462

Meteoric 10Be as a tracer of subglacial processes and interglacial surface exposure in Greenland

NASA Astrophysics Data System (ADS)

Graly, Joseph A.; Corbett, Lee B.; Bierman, Paul R.; Lini, Andrea; Neumann, Thomas A.

2018-07-01

In order to test whether sediment emerging from presently glaciated areas of Greenland was exposed near or at Earth's surface during previous interglacial periods, we measured the rare isotope 10Be contained in grain coatings of sediment collected at five ice marginal sites. Such grain coatings contain meteoric 10Be (10Bemet), which forms in the atmosphere and is deposited onto Earth's surface. Samples include sediment entrained in ice, glaciofluvial sediment collected at the ice margin, and subglacial sediment extracted during hot water drilling in the ablation zone. Due to burial by ice, contemporary subglacial sediment could only have acquired substantial 10Bemet concentrations during periods in the past when the Greenland Ice Sheet was less extensive than present. The highest measured 10Bemet concentrations are comparable to those found in well-developed, long-exposed soils, suggesting subglacial preservation and glacial transport of sediment exposed during preglacial or interglacial periods. Ice-bound sediment has significantly higher 10Bemet concentrations than glaciofluvial sediment, suggesting that glaciofluvial processes are sufficiently erosive to remove tracers of previous interglacial exposures. Northern Greenland sites where ice and sediment are supplied from the ice sheet's central main dome have significantly higher 10Bemet concentrations than sites in southern Greenland, indicating greater preglacial or interglacial landscape preservation in central Greenland than in the south. Because southern Greenland has more frequent and spatially extensive periods of glacial retreat but nevertheless has less evidence of past subaerial exposure, we suggest that 10Bemet measurements in glacial sediment are primarily controlled by erosional efficiency rather than interglacial exposure length.

EXECUTIVE SUMMARY OF STATE DATA RELATED TO ABANDONED CENTRALIZED AND COMMERCIAL DRILLING-FLUID DISPOSAL SITES IN LOUISIANA, NEW MEXICO, OKLAHOMA, AND TEXAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

H. Seay Nance

2003-03-01

This 2003 Spring Semi-Annual Report contains a summary of the Final Technical Report being prepared for the Soil Remediation Requirements at Commercial and Centralized Drilling-Fluid Disposal (CCDD) Sites project funded by the United States Department of Energy under DOE Award No. DE-AC26-99BC15225. The summary describes (1) the objectives of the investigation, (2) a rationale and methodology of the investigation, (3) sources of data, assessment of data quality, and data availability, (4) examples of well documented centralized and commercial drilling-fluid disposal (CCDD) sites and other sites where drilling fluid was disposed of, and (5) examples of abandoned sites and measures undertakenmore » for their assessment and remediation. The report also includes most of the figures, tables, and appendices that will be included in the final report.« less

Utilizing hydrologic, statistical, and geochemical tools to assess uranium mobility in surface and near-surface environments

NASA Astrophysics Data System (ADS)

Naftz, D. L.; Walton-Day, K. E.; Fuller, C.; Dam, W. L.; Briggs, M. A.; Snyder, T.

2015-12-01

Legacy uranium (U) mining and processing activities have resulted in soil and water contamination on Federal, state, and tribal lands in the western United States. Sites include legacy mill sites associated with U extraction now managed by the Department of Energy and thousands of waste dumps associated with U exploration, mining, and processing. Recently (2012), over 400,000 hectares of federally managed land in northern Arizona was withdrawn from consideration of mining for a 20-year period to protect the Grand Canyon watershed from potentially adverse effects of U mineral exploration and development. Ore from active and recently active U mines in the Colorado Plateau, the Henry Mountains Complex, and the Arizona Strip is transported to the only currently (2015) active conventional mill site in the western United States, located in Utah. Previous and ongoing U.S. Geological Survey assessments to examine U mobility at a variety of legacy and active sites associated with ore exploration, extraction, and processing will be presented as field-scale examples. Topics associated with site investigations will include: (1) offsite migration of radionuclides associated with the operation of the White Mesa U mill; (2) long-term contaminant transport from legacy U waste dumps on Bureau of Land Management regulated land in Utah; (3) application of incremental soil sampling techniques to determine pre- and post-mining radionuclide levels associated with planned and operating U mines in northern Arizona; (4) application of fiber optic digital temperature sensing equipment to identify areas where shallow groundwater containing elevated U levels may be discharging to a river adjacent to a reclaimed mill site in central Wyoming; and (5) field-scale manipulation of groundwater chemistry to limit U migration from a legacy upgrader site in southeastern Utah.

Representativeness of wind measurements in moderately complex terrain

NASA Astrophysics Data System (ADS)

van den Bossche, Michael; De Wekker, Stephan F. J.

2018-02-01

We investigated the representativeness of 10-m wind measurements in a 4 km × 2 km area of modest relief by comparing observations at a central site with those at four satellite sites located in the same area. Using a combination of established and new methods to quantify and visualize representativeness, we found significant differences in wind speed and direction between the four satellite sites and the central site. The representativeness of the central site wind measurements depended strongly on surface wind speed and direction, and atmospheric stability. Through closer inspection of the observations at one of the satellite sites, we concluded that terrain-forced flows combined with thermally driven downslope winds caused large biases in wind direction and speed. We used these biases to generate a basic model, showing that terrain-related differences in wind observations can to a large extent be predicted. Such a model is a cost-effective way to enhance an area's wind field determination and to improve the outcome of pollutant dispersion and weather forecasting models.

Exposure prediction approaches used in air pollution epidemiology studies: Keyfindings and future recommendations

EPA Science Inventory

Many epidemiologic studies of the health effects of exposure to ambient air pollution use measurements from central-site monitors as their exposure estimate. However, measurements from central-site monitors may lack the spatial and temporal resolution required to capture exposure...

Synthetic Minor NSR Permit: BP America Production Company - Treating Site #8 Central Delivery Point

EPA Pesticide Factsheets

This page contains the response to public comments and the final synthetic minor NSR permit for the BP America Production Company, Treating Site #8 Central Delivery Point, located on the Southern Ute Indian Reservation in La Plata County, CO.

Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H+-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8

PubMed Central

Yano, Kanako; Yanagisawa, Takahiro; Mukae, Kyosuke; Niwa, Yasuo; Inoue, Yuko; Moriyasu, Yuji

2015-01-01

Tobacco BY-2 cells undergo autophagy in sucrose-free culture medium, which is the process mostly responsible for intracellular protein degradation under these conditions. Autophagy was inhibited by the vacuolar H+-ATPase inhibitors concanamycin A and bafilomycin A1, which caused the accumulation of autophagic bodies in the central vacuoles. Such accumulation did not occur in the presence of the autophagy inhibitor 3-methyladenine, and concanamycin in turn inhibited the accumulation of autolysosomes in the presence of the cysteine protease inhibitor E-64c. Electron microscopy revealed not only that the autophagic bodies were accumulated in the central vacuole, but also that autophagosome-like structures were more frequently observed in the cytoplasm in treatments with concanamycin, suggesting that concanamycin affects the morphology of autophagosomes in addition to raising the pH of the central vacuole. Using BY-2 cells that constitutively express a fusion protein of autophagosome marker protein Atg8 and green fluorescent protein (GFP), we observed the appearance of autophagosomes by fluorescence microscopy, which is a reliable morphological marker of autophagy, and the processing of the fusion protein to GFP, which is a biochemical marker of autophagy. Together, these results suggest the involvement of vacuole type H+-ATPase in the maturation step of autophagosomes to autolysosomes in the autophagic process of BY-2 cells. The accumulation of autophagic bodies in the central vacuole by concanamycin is a marker of the occurrence of autophagy; however, it does not necessarily mean that the central vacuole is the site of cytoplasm degradation. PMID:26368310

Agreement of central site measurements and land use regression modeled oxidative potential of PM{sub 2.5} with personal exposure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Aileen, E-mail: Yang@uu.nl; Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, P.O. Box 80.178, 3508TD Utrecht; Hoek, Gerard

Oxidative potential (OP) of ambient particulate matter (PM) has been suggested as a health-relevant exposure metric. In order to use OP for exposure assessment, information is needed about how well central site OP measurements and modeled average OP at the home address reflect temporal and spatial variation of personal OP. We collected 96-hour personal, home outdoor and indoor PM{sub 2.5} samples from 15 volunteers living either at traffic, urban or regional background locations in Utrecht, the Netherlands. OP was also measured at one central reference site to account for temporal variations. OP was assessed using electron spin resonance (OP{sup ESR})more » and dithiothreitol (OP{sup DTT}). Spatial variation of average OP at the home address was modeled using land use regression (LUR) models. For both OP{sup ESR} and OP{sup DTT}, temporal correlations of central site measurements with home outdoor measurements were high (R>0.75), and moderate to high (R=0.49–0.70) with personal measurements. The LUR model predictions for OP correlated significantly with the home outdoor concentrations for OP{sup DTT} and OP{sup ESR} (R=0.65 and 0.62, respectively). LUR model predictions were moderately correlated with personal OP{sup DTT} measurements (R=0.50). Adjustment for indoor sources, such as vacuum cleaning and absence of fume-hood, improved the temporal and spatial agreement with measured personal exposure for OP{sup ESR}. OP{sup DTT} was not associated with any indoor sources. Our study results support the use of central site OP for exposure assessment of epidemiological studies focusing on short-term health effects. - Highlights: • Oxidative potential (OP) of PM was proposed as a health-relevant exposure metric. • We evaluated the relationship between measured and modeled outdoor and personal OP. • Temporal correlations of central site with personal OP are moderate to high. • Adjusting for indoor sources improved the agreement with personal OP. • Our results support the use of central site OP for short-term health effect studies.« less

Diversity patterns and composition of native and exotic floras in central Chile

NASA Astrophysics Data System (ADS)

Figueroa, Javier A.; Teillier, Sebastián; Castro, Sergio A.

2011-03-01

Floristic changes in the Mediterranean region of central Chile brought about by human impact appear to be shared with other climatic regions, although there is a notable absence of empirical studies and available quantitative evidence for the central Chile region. This study examines the cover, richness and composition of native and exotic plant species in a representative area of central Chile. Through floristic characterization of 33 sites sampled using 40 × 40 m plots distributed along transect on which the two farthest sites were separated by 50 km, the floristic richness and cover patterns, as well as the general land use characteristics were evaluated (native matorral, espinal, abandoned farming field, forest plantations, periurban sites, road sites, river bank, and burnt site). We recorded 327 species of plants; 213 species were native and 114 were exotic. The average number of species was heterogeneous in all sites, showing a greater relative native frequency in those sites with a lower level of anthropic intervention. Except for the matorral, the cover of exotic species was greater than that of native species. No relation was found between richness and cover in relation to the different types of land use. The relationship between cover of native and exotic was negative, although for richness did not show relationship. Results show that the exotic species are limited by resources, although they have not completely displaced the native species. The native and exotic floras respond to different spatial distribution patterns, so their presence makes it possible to establish two facts rarely quantified in central Chile: first, that the exotic flora replaces (but does not necessarily displace) the native flora, and second, that at the same time, because of its greater geographic ubiquity and the abundance levels that it achieves, it contributes to the taxonomic and physiognomic homogenization of central Chile.

Evaluating Ultraviolet Radiation Exposures Determined from TOMS Satellite Data at Sites of Amphibian Declines in Central and South America

NASA Technical Reports Server (NTRS)

Middleton, Elizabeth M.; Smith, David E. (Technical Monitor)

2000-01-01

Many amphibian species have experienced substantial population declines, or have disappeared altogether, during the last several decades at a number of amphibian census sites in Central and South America. This study addresses the use of satellite-derived trends in solar ultraviolet-B (UV-B; 280-320 nm) radiation exposures at these sites over the last two decades, and is intended to demonstrate a role for satellite observations in determining whether UV-B radiation is a contributing factor in amphibian declines. UV-B radiation levels at the Earth's surface were derived from the Total Ozone Mapping Spectrometer (TOMS) satellite data, typically acquired daily since 1979. These data were used to calculate the daily erythemal (sunburning) UV-B, or UV-B(sub ery), exposures at the latitude, longitude, and elevation of each of 20 census sites. The annually averaged UV-B(sub ery) dose, as well as the maximum values, have been increasing in both Central and South America, with higher levels received at the Central American sites. The annually averaged UV-B(sub ery) exposures increased significantly from 1979-1998 at all 11 Central American sites examined (r(exp 2) = 0.60 - 0.79; P<=0.015), with smaller but significant increases at five of the nine South American sites (r(exp 2) = 0.24-0.42; P<=0.05). The contribution of the highest UV-B(sub ery) exposure levels (>= 6750 J/sq m*d) to the annual UV-B(sub ery) total has increased from approx. 5% to approx. 15% in Central America over the 19 year period, but actual daily exposures for each species are unknown. Synergy among UV-B radiation and other factors, especially those associated with alterations of water chemistry (e.g., acidification) in aqueous habitats is discussed. These findings justify further research concerning whether UV-B(sub ery) radiation plays a role in amphibian population declines and extinctions.

Physical-Habitat and Geomorphic Data for Selected River Reaches in Central Arizona Basins, 1995-98

DTIC Science & Technology

2000-01-01

identification purposes only and does not constitute endorsement by the U.S. Geological Survey. Information regarding research and data-collection programs of...of measurement sites for Central Arizona Basins study area [<, less than] Site number (see fig. 1) Site name Station- identification number Latitude...measurements of instream characteristics, solar contribution to the system, and identification of riparian vegetation. The methods used to measure

KSC-04PD-0250

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. NASA Administrator Sean OKeefe (center) is welcomed to the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

2012 Annual Wastewater Reuse Report for the Idaho National Laboratory Site's Central facilities Area Sewage Treatment Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mike Lewis

2013-02-01

This report describes conditions, as required by the state of Idaho Wastewater Reuse Permit (#LA-000141-03), for the wastewater land application site at Idaho National Laboratory Site’s Central Facilities Area Sewage Treatment Plant from November 1, 2011, through October 31, 2012. The report contains the following information: • Site description • Facility and system description • Permit required monitoring data and loading rates • Status of compliance conditions and activities • Discussion of the facility’s environmental impacts. During the 2012 permit year, no wastewater was land-applied to the irrigation area of the Central Facilities Area Sewage Treatment Plant.

CyberShake Physics-Based PSHA in Central California

NASA Astrophysics Data System (ADS)

Callaghan, S.; Maechling, P. J.; Goulet, C. A.; Milner, K. R.; Graves, R. W.; Olsen, K. B.; Jordan, T. H.

2017-12-01

The Southern California Earthquake Center (SCEC) has developed a simulation platform, CyberShake, which performs physics-based probabilistic seismic hazard analyis (PSHA) using 3D deterministic wave propagation simulations. CyberShake performs PSHA by simulating a wavefield of Strain Green Tensors. An earthquake rupture forecast (ERF) is then extended by varying hypocenters and slips on finite faults, generating about 500,000 events per site of interest. Seismic reciprocity is used to calculate synthetic seismograms, which are processed to obtain intensity measures (IMs) such as RotD100. These are combined with ERF probabilities to produce hazard curves. PSHA results from hundreds of locations across a region are interpolated to produce a hazard map. CyberShake simulations with SCEC 3D Community Velocity Models have shown how the site and path effects vary with differences in upper crustal structure, and they are particularly informative about epistemic uncertainties in basin effects, which are not well parameterized by depths to iso-velocity surfaces, common inputs to GMPEs. In 2017, SCEC performed CyberShake Study 17.3, expanding into Central California for the first time. Seismic hazard calculations were performed at 1 Hz at 438 sites, using both a 3D tomographically-derived central California velocity model and a regionally averaged 1D model. Our simulation volumes extended outside of Central California, so we included other SCEC velocity models and developed a smoothing algorithm to minimize reflection and refraction effects along interfaces. CyberShake Study 17.3 ran for 31 days on NCSA's Blue Waters and ORNL's Titan supercomputers, burning 21.6 million core-hours and producing 285 million two-component seismograms and 43 billion IMs. These results demonstrate that CyberShake can be successfully expanded into new regions, and lend insights into the effects of directivity-basin coupling associated with basins near major faults such as the San Andreas. In particular, we observe in the 3D results that basin amplification for sites in the southern San Joaquin Valley is less than for sites in smaller basins such as around Ventura. We will present CyberShake hazard estimates from the 1D and 3D models, compare results to those from previous CyberShake studies and GMPEs, and describe our future plans.

Real-time simulation clock

NASA Technical Reports Server (NTRS)

Bennington, Donald R. (Inventor); Crawford, Daniel J. (Inventor)

1990-01-01

The invention is a clock for synchronizing operations within a high-speed, distributed data processing network. The clock is actually a distributed system comprising a central clock and multiple site clock interface units (SCIUs) which are connected by means of a fiber optic star network and which operate under control of separate clock software. The presently preferred embodiment is a part of the flight simulation system now in current use at the NASA Langley Research Center.

Archaeological Investigations at Nonhabitation and Burial Sites, Chief Joseph Dam Project, Washington.

DTIC Science & Technology

1984-01-01

Burial 2, 45-D0-244, showing cyst, matting, lithic cache, and organic concentrations ..... .......... 96 Figure 5-6. Rocks and charcoal from 80-100 cm...Hawkes Since archaeological Investigations In north-central Washington have been concentrated along the reservoirs of the Columbia River, the...vinylite resin, acetone, and methyl -isobutyl ketone, which acts as a bonding agent while impregnating the material to be preserved. Although the process of

NOAA Photo Library - Credits

Science.gov Websites

NOAA Photo Library Banner Takes you to the Top Page Takes you to the About this Site page. Takes . Skip Theberge (NOAA Central Library) -- Collection development, site content, image digitization, and database construction. Kristin Ward (NOAA Central Library) -- HTML page construction Without the generosity

THE USE OF LIGHT SCATTERING DATA TO ESTIMATE THE CONTRIBUTION OF INDOOR- AND OUTDOOR-GENERATED PARTICLES TO INDOOR AIR

EPA Science Inventory

Many epidemiologic studies have shown an association between adverse health effects and particulate concentrations measured at centrally located sites. Other studies have been conducted to examine relationships between personal exposures and central site measurements. Few stu...

CNS sites cooperate to detect duplicate subjects with a clinical trial subject registry.

PubMed

Shiovitz, Thomas M; Wilcox, Charles S; Gevorgyan, Lilit; Shawkat, Adnan

2013-02-01

To report the results of the first 1,132 subjects in a pilot project where local central nervous system trial sites collaborated in the use of a subject database to identify potential duplicate subjects. Central nervous system sites in Los Angeles and Orange County, California, were contacted by the lead author to seek participation in the project. CTSdatabase, a central nervous system-focused trial subject registry, was utilized to track potential subjects at pre-screen. Subjects signed an institutional review board-approved authorization prior to participation, and site staff entered their identifiers by accessing a website. Sites were prompted to communicate with each other or with the database administrator when a match occurred between a newly entered subject and a subject already in the database. Between October 30, 2011, and August 31, 2012, 1,132 subjects were entered at nine central nervous system sites. Subjects continue to be entered, and more sites are anticipated to begin participation by the time of publication. Initially, there were concerns at a few sites over patient acceptance, financial implications, and/or legal and privacy issues, but these were eventually overcome. Patient acceptance was estimated to be above 95 percent. Duplicate Subjects (those that matched several key identifiers with subjects at different sites) made up 7.78 percent of the sample and Certain Duplicates (matching identifiers with a greater than 1 in 10 million likelihood of occurring by chance in the general population) accounted for 3.45 percent of pre-screens entered into the database. Many of these certain duplicates were not consented for studies because of the information provided by the registry. The use of a clinical trial subject registry and cooperation between central nervous system trial sites can reduce the number of duplicate and professional subjects entering clinical trials. To be fully effective, a trial subject database could be integrated into protocols across pharmaceutical companies, thereby mandating site participation and increasing the likelihood that duplicate subjects will be removed before they enter (and negatively affect) clinical trials.

Seasonal variations of dissolved organic carbon in precipitation over urban and forest sites in central Poland.

PubMed

Siudek, Patrycja; Frankowski, Marcin; Siepak, Jerzy

2015-07-01

Spatial and temporal variability of carbon species in rainwater (bulk deposition) was studied for the first time at two sites located in urban area of Poznań City and protected woodland area (Jeziory), in central Poland, between April and December 2013. The mean concentration of total carbon (TC) for the first site was 5.86 mg L(-1), whereas for the second, 5.21 mg L(-1). Dissolved organic carbon (DOC) concentration accounted for, on average, 87 and 91 % of total carbon in precipitation at urban and non-urban sites, respectively. Significant changes in TC concentrations in rainwater were observed at both sites, indicating that atmospheric transformation, transport, and removal mechanisms of carbonaceous particles were affected by seasonal fluctuations in biogenic/anthropogenic emission and meteorological conditions (i.e., precipitation height and type, atmospheric transport). During the warm season, the DOC concentration in rainwater was mostly influenced by mixed natural and anthropogenic sources. In contrast, during the cold season, the DOC concentration significantly increased mainly as a result of anthropogenic activities, i.e., intensive coal combustion, domestic wood burning, high-temperature processes, etc. In addition, during the winter measurements, significant differences in mean DOC concentration (Kruskal-Wallis test, p < 0.05) were determined for rain, mixed rain-snow, and snow samples. It was found that rainwater TOC concentration measured in Poznań and Jeziory reflected a combination of local, regional, and distant sources. Backward trajectory analysis showed that air masses advected from polluted regions in western Europe largely affect the DOC amount in rainwater, both at urban and non-urban sites. These data imply that carbonaceous compounds are of crucial importance in atmospheric chemistry and should be considered as an important parameter while considering wet deposition, reactions with different substances, especially over polluted environments.

Different thresholds for detecting osteophytes and joint space narrowing exist between the site investigators and the centralized reader in a multicenter knee osteoarthritis study—data from the Osteoarthritis Initiative

PubMed Central

Guermazi, Ali; Hunter, David J.; Li, Ling; Benichou, Olivier; Eckstein, Felix; Kwoh, C. Kent; Nevitt, Michael

2011-01-01

Objective To evaluate how the reading of knee radiographs by site investigators differs from that by an expert musculoskeletal radiologist who trained and validated them in a multicenter knee osteoarthritis (OA) study. Materials and methods A subset of participants from the Osteoarthritis Initiative progression cohort was studied. Osteophytes and joint space narrowing (JSN) were evaluated using Kellgren-Lawrence (KL) and Osteoarthritis Research Society International (OARSI) grading. Radiographs were read by site investigators, who received training and validation of their competence by an expert musculoskeletal radiologist. Radiographs were re-read by this radiologist, who acted as a central reader. For KL and OARSI grading of osteophytes, discrepancies between two readings were adjudicated by another expert reader. Results Radiographs from 96 subjects (49 women) and 192 knees (138 KL grade≥2) were included. The site reading showed moderate agreement for KL grading overall (kappa=0.52) and for KL≥2 (i.e., radiographic diagnosis of “definite OA”; kappa=0.41). For OARSI grading, the site reading showed substantial agreement for lateral and medial JSN (kappa=0.65 and 0.71), but only fair agreement for osteophytes (kappa=0.37). For KL grading, the adjudicator’s reading showed substantial agreement with the centralized reading (kappa=0.62), but only slight agreement with the site reading (kappa=0.10). Conclusion Site investigators over-graded osteophytes compared to the central reader and the adjudicator. Different thresholds for scoring of JSN exist even between experts. Our results suggest that research studies using radiographic grading of OA should use a centralized reader for all grading. PMID:21479521

Water quality and habitat conditions in upper Midwest streams relative to riparian vegetation and soil characteristics, August 1997 : study design, methods, and data

USGS Publications Warehouse

Sorenson, S.K.; Porter, S.D.; Akers, K.B.; Harris, M.A.; Kalkhoff, S.J.; Lee, K.E.; Roberts, L.; Terrio, P.J.

1999-01-01

Water-chemistry, biological, and habitat data were collected from 70 sites on Midwestern streams during August 1997 as part of an integrated, regional water-quality assessment by the U.S. Geological Survey National Water-Quality Assessment (NAWQA) Program. The study area includes the Corn Belt region of southern Minnesota, eastern Iowa, and west-central Illinois, one of the most intensive and productive agricultural regions of the world. The focus of the study was to evaluate the condition of woodedriparian zones and the influence of basin soildrainage characteristics on water quality and biological-community responses. This report includes a description of the study design and site-characterization process, sample-collection and processing methods, laboratory methods, quality-assurance procedures, and summaries of data on nutrients, herbicides and metabolites, stream productivity and respiration, biological communities, habitat conditions, and agriculturalchemical and land-use information.

Application of geographical information system in disposal site selection for hazardous wastes.

PubMed

Rezaeimahmoudi, Mehdi; Esmaeli, Abdolreza; Gharegozlu, Alireza; Shabanian, Hassan; Rokni, Ladan

2014-01-01

The aim of this study was to provide a scientific method based on Geographical Information System (GIS) regarding all sustainable development measures to locate a proper landfill for disposal of hazardous wastes, especially industrial (radioactive) wastes. Seven effective factors for determining hazardous waste landfill were applied in Qom Province, central Iran. These criteria included water, slope, population centers, roads, fault, protected areas and geology. The Analysis Hierarchical Process (AHP) model based on pair comparison was used. First, the weight of each factor was determined by experts; afterwards each layer of maps entered to ARC GIS and with special weight multiplied together, finally the best suitable site was introduced. The most suitable sites for burial were in northwest and west of Qom Province and eventually five zones were introduced as the sample sites. GIs and AHP model is introduced as the technical, useful and accelerator tool for disposal site selection. Furthermore it is determined that geological factor is the most effective layer for site selection. It is suggested that geological conditions should be considered primarily then other factors are taken into consideration.

Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes

PubMed Central

Dalet, Farfán-García Eunice; Guadalupe, Trujillo-Ferrara José; María del Carmen, Castillo-Hernández; Humberto, Guerra-Araiza Christian; Antonio, Soriano-Ursúa Marvin

2013-01-01

In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selectivity of ligands for G-protein coupled receptors, and that signaling by these receptors involves both G-protein dependent and independent pathways. The present review outlines the physiological and pharmacological implications of this perspective for the design of new drugs to treat disorders of the central nervous system. Specifically, new possibilities are explored in relation to allosteric and orthosteric binding sites on dopamine receptors for the treatment of Parkinson's disease, and on muscarinic receptors for Alzheimer's disease. Future research can seek to identify ligands that can bind to more than one site on the same receptor, or simultaneously bind to two receptors and form a dimer. For example, the design of bivalent drugs that can reach homo/hetero-dimers of D2 dopamine receptor holds promise as a relevant therapeutic strategy for Parkinson's disease. Regarding the treatment of Alzheimer's disease, the design of dualsteric ligands for mono-oligomeric rinic receptors could increase therapeutic effectiveness by generating potent compounds that could activate more than one signaling pathway. PMID:25206539

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats

PubMed Central

Knight, Colette M.; Gutierrez-Juarez, Roger; Lam, Tony K.T.; Arrieta-Cruz, Isabel; Huang, Loli; Schwartz, Gary; Barzilai, Nir; Rossetti, Luciano

2011-01-01

OBJECTIVE Sirtuin 1 (SIRT1) and its activator resveratrol are emerging as major regulators of metabolic processes. We investigate the site of resveratrol action on glucose metabolism and the contribution of SIRT1 to these effects. Because the arcuate nucleus in the mediobasal hypothalamus (MBH) plays a pivotal role in integrating peripheral metabolic responses to nutrients and hormones, we examined whether the actions of resveratrol are mediated at the MBH. RESEARCH DESIGN AND METHODS Sprague Dawley (SD) male rats received acute central (MBH) or systemic injections of vehicle, resveratrol, or SIRT1 inhibitor during basal pancreatic insulin clamp studies. To delineate the pathway(s) by which MBH resveratrol modulates hepatic glucose production, we silenced hypothalamic SIRT1 expression using a short hairpin RNA (shRNA) inhibited the hypothalamic ATP-sensitive potassium (KATP) channel with glibenclamide, or selectively transected the hepatic branch of the vagus nerve while infusing resveratrol centrally. RESULTS Our studies show that marked improvement in insulin sensitivity can be elicited by acute administration of resveratrol to the MBH or during acute systemic administration. Selective inhibition of hypothalamic SIRT1 using a cell-permeable SIRT1 inhibitor or SIRT1-shRNA negated the effect of central and peripheral resveratrol on glucose production. Blockade of the KATP channel and hepatic vagotomy significantly attenuated the effect of central resveratrol on hepatic glucose production. In addition, we found no evidence for hypothalamic AMPK activation after MBH resveratrol administration. CONCLUSIONS Taken together, these studies demonstrate that resveratrol improves glucose homeostasis mainly through a central SIRT1-dependent pathway and that the MBH is a major site of resveratrol action. PMID:21896928

The rapid yellowing of spruce at a mountain site in the Central Black Forest (Germany). Combined effects of Mg deficiency and ozone on biochemical, physiological and structural properties of the chloroplasts.

PubMed

Siefermann-Harms, Dorothea; Boxler-Baldoma, Carmen; von Wilpert, Klaus; Heumann, Hans-Günther

2004-04-01

Biochemical, physiological and ultrastructural changes of the chloroplasts were examined in the course of the rapid yellowing process of spruce (Picea abies (L.) Karst.) at a Mg-deficient and ozone polluted mountain site (Schöllkopf mountain, Central Black Forest, Germany, 840 m a.s.l.). While at an early stage of yellowing the chlorophyll (Chl) content of the needles decreased slowly, significant changes occurred in the chloroplasts: The lability of the light-harvesting Chl a/b protein complex LHC II increased; the thylakoid cross-sectional area of chloroplasts in the outer mesophyll of the needles decreased, and their Chl fluorescence showed typical changes like the decrease of Fv/Fm and the increase of the photoinhibitory Fv quenching. Later on, the Chl content decreased rapidly, the changes in the chloroplasts continued and the needles turned yellow. Lutein and the pigments of the xanthophyll cycle were enhanced in relation to Chl a. Light and dark reactions of the xanthophyll cycle were highly active indicating efficient proton pumping and NADPH formation. The ratio of nonappressed to appressed thylakoid membranes increased with decreasing Fv/Fm suggesting that structural and fluorescence properties of the chloroplasts were related. The response of the needles to defined shading and improved Mg supply was also examined. The combined effects of strong sun light, low levels of non-Chl-bound Mg (Mg(free)) and ozone concentrations exceeding 80 microg m(-3) are shown to be necessary to induce the rapid yellowing process. For needles with Mg(free) < 0.12 mg g(-1) needle dry matter, the lability of the LHC II was correlated with the ozone concentration suggesting that the destabilization of the LHC II plays a central role in the rapid yellowing process.

The Central Nervous System Sites Mediating the Orexigenic Actions of Ghrelin

PubMed Central

Mason, B.L.; Wang, Q.; Zigman, J.M.

2014-01-01

The peptide hormone ghrelin is important for both homeostatic and hedonic eating behaviors, and its orexigenic actions occur mainly via binding to the only known ghrelin receptor, the growth hormone secretagogue receptor (GHSR). GHSRs are located in several distinct regions of the central nervous system. This review discusses those central nervous system sites that have been found to play critical roles in the orexigenic actions of ghrelin, including hypothalamic nuclei, the hippocampus, the amygdala, the caudal brain stem, and midbrain dopaminergic neurons. Hopefully, this review can be used as a stepping stone for the reader wanting to gain a clearer understanding of the central nervous system sites of direct ghrelin action on feeding behavior, and as inspiration for future studies to provide an even-more-detailed map of the neurocircuitry controlling eating and body weight. PMID:24111557

Central Venous Catheter Insertion Site and Colonization in Pediatric Cardiac Surgery

ClinicalTrials.gov

2017-11-04

Central Line-associated Bloodstream Infection (CLABSI); Central Venous Catheter Associated Bloodstream Infection; Heart; Surgery, Heart, Functional Disturbance as Result; Congenital Heart Disease; Newborn; Infection

Siting industrial waste land disposal facilities in Thailand: A risk based approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fingleton, D.J.; Habegger, L.; Peters, R.

The Thailand Industrial Works Department (IWD) has established a toxic industrial waste Central Treatment and Stabilization Center (CTSC) for textile dyeing and electroplating industries located in the Thonburi region of the Bangkok metropolitan area. Industrial waste is treated, stabilized, and stored at the CTSC. Although the IWD plans to ship the stabilized sludge to the Ratchaburi Province in western Thailand for burial, the location for the land disposal site has not been selected. Assessing the relative health risks from exposure to toxic chemicals released from an industrial waste land disposal site is a complicated, data-intensive process that requires a multidisciplinarymore » approach. This process is further complicated by the unique physical and cultural characteristics exhibited by the rapidly industrializing Thai economy. The purpose of this paper is to describe the research approach taken and to detail the constraints to health risk assessments in Thailand. issues discussed include data availability and quality, effectiveness of control or mitigation methods, cultural differences, and the basic assumptions inherent in many of the risk assessment components.« less

Real-time digital data-acquisition system for determining load characteristics. Volume 2: Operating, programming and maintenance instructions

NASA Astrophysics Data System (ADS)

Podesto, B.; Lapointe, A.; Larose, G.; Robichaud, Y.; Vaillancourt, C.

1981-03-01

The design and construction of a Real-Time Digital Data Acquisition System (RTDDAS) to be used in substations for on-site recording and preprocessing load response data were included. The gathered data can be partially processed on site to compute the apparent, active and reactive powers, voltage and current rms values, and instantaneous values of phase voltages and currents. On-site processing capability is provided for rapid monitoring of the field data to ensure that the test setup is suitable. Production analysis of field data is accomplished off-line on a central computer from data recorded on a dual-density (800/1600) magnetic tape which is IBM-compatible. Parallel channels of data can be recorded at a variable rate from 480 to 9000 samples per second per channel. The RTDDAS is housed in a 9.1 m (30-ft) trailer which is shielded from electromagnetic interference and protected by isolators from switching surges. The test must sometimes be performed. Information pertaining to the installation, software operation, and maintenance is presented.

Forest-site relationships within an outbreak of lodgepole needle miner in central Oregon.

Treesearch

Richard R. Mason; Timothy C. Tigner

1972-01-01

The distribution of an outbreak population of lodgepole needle miner, Coleotechnites near milleri (Busck), in central Oregon was studied in relation to forest stand and site characteristics. The outbreak occurred primarily in topographic basins where lodgepole pine, Pinus contorta Douglas, grows in pure...

Relationship Between PM2.5 Collected at Residential Outdoor Locations and a Central Site

EPA Science Inventory

Regression models are developed to describe the relationship between ambient PM_2.5 (particulate matter [PM] ≤ _2.5 μm in aerodynamic diameter) mass concentrations measured at a central-site monitor with those at residential outdoor monitors. Understanding the...

Introduction to the Watershed Central Web Site and Watershed Wiki Mini-Workshop

EPA Science Inventory

Many communities across the country struggle to find the right approaches, tools and data to include in their watershed plans. EPA recently posted a new web site called "Watershed Central,” a “one-stop" tool, to help watershed organizations and others find key resources to protec...

Spatiotemporally‐Resolved Air Exchange Rate as a Modifier of Acute Air Pollution‐Related Morbidity in AtlantaMorbidity in Atlanta

EPA Science Inventory

Epidemiological studies frequently use central site concentrations as surrogates of exposure to air pollutants. Variability in air pollutant infiltration due to differential air exchange rates (AERs) is potentially a major factor affecting the relationship between central site c...

KENNEDY SPACE CENTER, FLA. - NASA officials and government representatives are gathered to learn about the assets of the Central Florida Research Park, near Orlando. At the far end of the table is NASA Administrator Sean O’Keefe. He is flanked, on the left, by Florida Congressman Tom Feeney and U.S. Senator Bill Nelson; and on the right by U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA officials and government representatives are gathered to learn about the assets of the Central Florida Research Park, near Orlando. At the far end of the table is NASA Administrator Sean O’Keefe. He is flanked, on the left, by Florida Congressman Tom Feeney and U.S. Senator Bill Nelson; and on the right by U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Tackling the Challenge of Deep Vadose Zone Remediation at the Hanford Site

NASA Astrophysics Data System (ADS)

Morse, J. G.; Wellman, D. M.; Gephart, R.

2010-12-01

The Central Plateau of the Hanford Site in Washington State contains some 800 waste disposal sites where 1.7 trillion liters of contaminated water was once discharged into the subsurface. Most of these sites received liquids from the chemical reprocessing of spent uranium fuel to recover plutonium. In addition, 67 single shell tanks have leaked or are suspected to have leaked 3.8 million liters of high alkali and aluminate rich cesium-contaminated liquids into the sediment. Today, this inventory of subsurface contamination contains an estimated 550,000 curies of radioactivity and 150 million kg (165,000 tons) of metals and hazardous chemicals. Radionuclides range from mobile 99Tc to more immobilized 137Cs, 241Am, uranium, and plutonium. A significant fraction of these contaminants likely remain within the deep vadose zone. Plumes of groundwater containing tritium, nitrate, 129I and other contaminants have migrated through the vadose zone and now extend outward from the Central Plateau to the Columbia River. During most of Hanford Site history, subsurface studies focused on groundwater monitoring and characterization to support waste management decisions. Deep vadose zone studies were not a priority because waste practices relied upon that zone to buffer contaminant releases into the underlying aquifer. Remediation of the deep vadose zone is now central to Hanford Site cleanup because these sediments can provide an ongoing source of contamination to the aquifer and therefore to the Columbia River. However, characterization and remediation of the deep vadose zone pose some unique challenges. These include sediment thickness; contaminant depth; coupled geohydrologic, geochemical, and microbial processes controlling contaminant spread; limited availability and effectiveness of traditional characterization tools and cleanup remedies; and predicting contaminant behavior and remediation performance over long time periods and across molecular to field scales. The U.S Department of Energy recognizes these challenges and is committed to a sustained, focused effort of continuing to apply existing technologies where feasible while investing and developing in new innovative, field-demonstrated capabilities supporting longer-term basic and applied research to establish the technical underpinning for solving intractable deep vadose zone problems and implementing final remedies. This approach will rely upon Multi-Project Teams focusing on coordinated projects across multiple DOE offices, programs, and site contractors plus the facilitation of basic and applied research investments through implementing a Deep Vadose Zone Applied Field Research Center and other scientific studies.

Full-Time, Eye-Safe Cloud and Aerosol Lidar Observation at Atmospheric Radiation Measurement Program Sites: Instruments and Data Analysis

NASA Technical Reports Server (NTRS)

Campbell, James R.; Hlavka, Dennis L.; Welton, Ellsworth J.; Flynn, Connor J.; Turner, David D.; Spinhirne, James D.; Scott, V. Stanley, III; Hwang, I. H.; Einaudi, Franco (Technical Monitor)

2001-01-01

Atmospheric radiative forcing, surface radiation budget, and top of the atmosphere radiance interpretation involves a knowledge of the vertical height structure of overlying cloud and aerosol layers. During the last decade, the U.S. Department of Energy through I the Atmospheric Radiation Measurement (ARM) program has constructed four long- term atmospheric observing sites in strategic climate regimes (north central Oklahoma, In Barrow. Alaska, and Nauru and Manus Islands in the tropical western Pacific). Micro Pulse Lidar (MPL) systems provide continuous, autonomous observation of all significant atmospheric cloud and aerosol at each of the central ARM facilities. Systems are compact and transmitted pulses are eye-safe. Eye-safety is achieved by expanding relatively low-powered outgoing Pulse energy through a shared, coaxial transmit/receive telescope. ARM NIPL system specifications, and specific unit optical designs are discussed. Data normalization and calibration techniques are presented. A multiple cloud boundary detection algorithm is also described. These techniques in tandem represent an operational value added processing package used to produce normalized data products for Cloud and aerosol research and the historical ARM data archive.

Distribution of sup 125 I-neurotensin binding sites in human forebrain: Comparison with the localization of acetylcholinesterase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szigethy, E.; Quirion, R.; Beaudet, A.

1990-07-22

The distribution of 125I-neurotensin binding sites was compared with that of acetylcholinesterase reactivity in the human basal forebrain by using combined light microscopic radioautography/histochemistry. High 125I-neurotensin binding densities were observed in the bed nucleus of the stria terminalis, islands of Calleja, claustrum, olfactory tubercle, and central nucleus of the amygdala; lower levels were seen in the caudate, putamen, medial septum, diagonal band nucleus, and nucleus basalis of Meynert. Adjacent sections processed for cholinesterase histochemistry demonstrated a regional overlap between the distribution of labeled neurotensin binding sites and that of intense acetylcholinesterase staining in all of the above regions, except inmore » the bed nucleus of the stria terminalis, claustrum, and central amygdaloid nucleus, where dense 125I-neurotensin labeling was detected over areas containing only weak to moderate cholinesterase staining. At higher magnification, 125I-neurotensin-labeled binding sites in the islands of Calleja, supraoptic nucleus of the hypothalamus, medial septum, diagonal band nucleus, and nucleus basalis of Meynert were selectively associated with neuronal perikarya found to be cholinesterase-positive in adjacent sections. Moderate 125I-neurotensin binding was also apparent over the cholinesterase-reactive neuropil of these latter three regions. These data suggest that neurotensin (NT) may directly influence the activity of magnocellular cholinergic neurons in the human basal forebrain, and may be involved in the physiopathology of dementing disorders such as Alzheimer's disease, in which these neurons have been shown to be affected.« less

Demonstration-site development and phytoremediation processes associated with trichloroethene (TCE) in ground water, Naval Air Station-Joint Reserve Base Carswell Field, Fort Worth, Texas

USGS Publications Warehouse

Shah, Sachin D.; Braun, Christopher L.

2004-01-01

A field-scale phytoremediation demonstration study was initiated in 1996 by the U.S. Geological Survey (USGS), in cooperation with the U.S. Air Force, at a site on Naval Air StationJoint Reserve Base Carswell Field (NAS–JRB) adjacent to Air Force Plant 4 (AFP4) in Fort Worth, Tex. (fig. 1). Trichloroethene (TCE) has been used at AFP4 in aircraft manufacturing processes for decades; spills and leaks from tanks in the manufacturing building have resulted in shallow ground-water contamination on-site and downgradient from the facility (Eberts and others, 2003). The objective of the study was to determine the effectiveness of eastern cottonwoods (Populus deltoides) in decreasing the mass of dissolved TCE in ground water through phytoremediation. Phytoremediation is a process by which plants decrease the mass of a contaminant through a variety of chemical, physical, and biological means. Before development of the phytoremediation demonstration site, natural attenuation of TCE at the site occurred by sorption, dispersion, dilution, and possibly volatilization (Eberts and others, 2003).Long-term, field-scale monitoring and evaluation of this site contribute to the understanding of the processes associated with phytoremediation and provide practical information about field-scale applications of the method. This fact sheet briefly summarizes the development of the phytoremediation demonstration site at NAS–JRB and describes some of the physical and chemical processes associated with phytoremediation. The phytoremediation demonstration site is on the southern edge of the central lobe of a TCE plume in the surficial (alluvial) aquifer. The plume originates at AFP4 about 0.9 mile upgradient from the site (fig. 1). The 9.5-acre site is in the northwestern corner of the golf course on NAS–JRB. The saturated thickness of the alluvial aquifer, which is composed of clay, silt, sand, and gravel, ranges from about 1.5 to 5 feet at the site. The total thickness of the alluvial aquifer ranges from about 6 to 15 feet. The Goodland-Walnut confining unit, composed of massively bedded shaley limestone, underlies the alluvial aquifer. The general direction of ground-water flow in the study area (fig. 2) is from northwest to southeast, approximately perpendicular to the long sides of the cottonwood plantations. Ground water flows toward Farmers Branch Creek in the area southwest of the golf cart path. At the time of site characterization in August 1996, depth to water ranged from 8 to 13 feet below land surface.

Multi-hazard risk analysis for management strategies

NASA Astrophysics Data System (ADS)

Kappes, M.; Keiler, M.; Bell, R.; Glade, T.

2009-04-01

Risk management is very often operating in a reactive way, responding to an event, instead of proactive starting with risk analysis and building up the whole process of risk evaluation, prevention, event management and regeneration. Since damage and losses from natural hazards raise continuously more and more studies, concepts (e.g. Switzerland or South Tyrol-Bolozano) and software packages (e.g. ARMAGEDOM, HAZUS or RiskScape) are developed to guide, standardize and facilitate the risk analysis. But these approaches focus on different aspects and are mostly closely adapted to the situation (legislation, organization of the administration, specific processes etc.) of the specific country or region. We propose in this study the development of a flexible methodology for multi-hazard risk analysis, identifying the stakeholders and their needs, processes and their characteristics, modeling approaches as well as incoherencies occurring by combining all these different aspects. Based on this concept a flexible software package will be established consisting of ArcGIS as central base and being complemented by various modules for hazard modeling, vulnerability assessment and risk calculation. Not all modules will be developed newly but taken from the current state-of-the-art and connected or integrated into ArcGIS. For this purpose two study sites, Valtellina in Italy and Bacelonnette in France, were chosen and the hazards types debris flows, rockfalls, landslides, avalanches and floods are planned to be included in the tool for a regional multi-hazard risk analysis. Since the central idea of this tool is its flexibility this will only be a first step, in the future further processes and scales can be included and the instrument thus adapted to any study site.

Encoding of the cough reflex in anesthetized guinea pigs

PubMed Central

Mori, Nanako

2011-01-01

We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally in the nucleus tractus solitarius (nTS). In the present study, we have addressed the hypothesis that the primary central synapses of the cough receptors subserve an essential role in the encoding of cough. We found that cough requires sustained, high-frequency (≥8-Hz) afferent nerve activation. We also found evidence for processes that both facilitate (summation, sensitization) and inhibit the initiation of cough. Sensitization of cough occurs with repetitive subthreshold activation of the cough receptors or by coincident activation of C-fibers and/or nTS neurokinin receptor activation. Desensitization of cough evoked by repetitive and/or continuous afferent nerve activation has a rapid onset (<60 s) and does not differentiate between tussive stimuli, suggesting a central nervous system-dependent process. The cough reflex can also be actively inhibited upon activation of other airway afferent nerve subtypes, including slowly adapting receptors and pulmonary C-fibers. The sensitization and desensitization of cough are likely attributable to the prominent, primary, and unique role of N-methyl-d-aspartate receptor-dependent signaling at the central synapses of the cough receptors. These attributes may have direct relevance to the presentation of cough in disease and for the effectiveness of antitussive therapies. PMID:20926760

Auditory and audio-visual processing in patients with cochlear, auditory brainstem, and auditory midbrain implants: An EEG study.

PubMed

Schierholz, Irina; Finke, Mareike; Kral, Andrej; Büchner, Andreas; Rach, Stefan; Lenarz, Thomas; Dengler, Reinhard; Sandmann, Pascale

2017-04-01

There is substantial variability in speech recognition ability across patients with cochlear implants (CIs), auditory brainstem implants (ABIs), and auditory midbrain implants (AMIs). To better understand how this variability is related to central processing differences, the current electroencephalography (EEG) study compared hearing abilities and auditory-cortex activation in patients with electrical stimulation at different sites of the auditory pathway. Three different groups of patients with auditory implants (Hannover Medical School; ABI: n = 6, CI: n = 6; AMI: n = 2) performed a speeded response task and a speech recognition test with auditory, visual, and audio-visual stimuli. Behavioral performance and cortical processing of auditory and audio-visual stimuli were compared between groups. ABI and AMI patients showed prolonged response times on auditory and audio-visual stimuli compared with NH listeners and CI patients. This was confirmed by prolonged N1 latencies and reduced N1 amplitudes in ABI and AMI patients. However, patients with central auditory implants showed a remarkable gain in performance when visual and auditory input was combined, in both speech and non-speech conditions, which was reflected by a strong visual modulation of auditory-cortex activation in these individuals. In sum, the results suggest that the behavioral improvement for audio-visual conditions in central auditory implant patients is based on enhanced audio-visual interactions in the auditory cortex. Their findings may provide important implications for the optimization of electrical stimulation and rehabilitation strategies in patients with central auditory prostheses. Hum Brain Mapp 38:2206-2225, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis

PubMed Central

Cattaneo, Ruggero; Marci, Maria Chiara; Pietropaoli, Davide; Ortu, Eleonora

2017-01-01

Dysregulation of Autonomic Nervous System (ANS) and central pain pathways in temporomandibular disorders (TMD) is a growing evidence. Authors include some forms of TMD among central sensitization syndromes (CSS), a group of pathologies characterized by central morphofunctional alterations. Central Sensitization Inventory (CSI) is useful for clinical diagnosis. Clinical examination and CSI cannot identify the central site(s) affected in these diseases. Ultralow frequency transcutaneous electrical nerve stimulation (ULFTENS) is extensively used in TMD and in dental clinical practice, because of its effects on descending pain modulation pathways. The Diagnostic Criteria for TMD (DC/TMD) are the most accurate tool for diagnosis and classification of TMD. However, it includes CSI to investigate central aspects of TMD. Preliminary data on sensory ULFTENS show it is a reliable tool for the study of central and autonomic pathways in TMD. An alternative classification based on the presence of Central Sensitization and on individual response to sensory ULFTENS is proposed. TMD may be classified into 4 groups: (a) TMD with Central Sensitization ULFTENS Responders; (b) TMD with Central Sensitization ULFTENS Nonresponders; (c) TMD without Central Sensitization ULFTENS Responders; (d) TMD without Central Sensitization ULFTENS Nonresponders. This pathogenic classification of TMD may help to differentiate therapy and aetiology. PMID:28932132

KSC-04PD-0249

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. NASA Administrator Sean OKeefe (right) greets Florida Congressman Tom Feeney during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

KSC-04PD-0252

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. NASA Administrator Sean OKeefe (left) greets U.S. Representative Ric Keller during a tour of the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Development of a Distance-to-Roadway Proximity Metric to Compare Near-Road Pollutant Levels to a Central Site Monitor

EPA Science Inventory

The primary objective of the Detroit Exposure and Aerosol Research Study (DEARS) was to compare air pollutant concentrations measured at various neighborhoods, or exposure monitoring areas (EMAs), throughout a major metropolitan area to levels measured at a central site or commun...

NOAA History - About This Site

Science.gov Websites

.), presently with the NOAA Central Library as a Technical Information Specialist. Weather Bureau History : Dr others. Coast and Geodetic Survey History: Captain Albert E. Theberge, NOAA Corps (ret.), NOAA Central NOAA History Banner gold bar divider home - takes you to index page about the site contacts noaa

Techniques for estimating monthly mean streamflow at gaged sites and monthly streamflow duration characteristics at ungaged sites in central Nevada

USGS Publications Warehouse

Hess, G.W.; Bohman, L.R.

1996-01-01

Techniques for estimating monthly mean streamflow at gaged sites and monthly streamflow duration characteristics at ungaged sites in central Nevada were developed using streamflow records at six gaged sites and basin physical and climatic characteristics. Streamflow data at gaged sites were related by regression techniques to concurrent flows at nearby gaging stations so that monthly mean streamflows for periods of missing or no record can be estimated for gaged sites in central Nevada. The standard error of estimate for relations at these sites ranged from 12 to 196 percent. Also, monthly streamflow data for selected percent exceedence levels were used in regression analyses with basin and climatic variables to determine relations for ungaged basins for annual and monthly percent exceedence levels. Analyses indicate that the drainage area and percent of drainage area at altitudes greater than 10,000 feet are the most significant variables. For the annual percent exceedence, the standard error of estimate of the relations for ungaged sites ranged from 51 to 96 percent and standard error of prediction for ungaged sites ranged from 96 to 249 percent. For the monthly percent exceedence values, the standard error of estimate of the relations ranged from 31 to 168 percent, and the standard error of prediction ranged from 115 to 3,124 percent. Reliability and limitations of the estimating methods are described.

Structural Insights into Central Hypertension Regulation by Human Aminopeptidase A*

PubMed Central

Yang, Yang; Liu, Chang; Lin, Yi-Lun; Li, Fang

2013-01-01

Hypertension is regulated through both the central and systemic renin-angiotensin systems. In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium. Here, we determined the crystal structures of human APA and its complexes with different ligands and identified a calcium-binding site in the S1 pocket of APA. Without calcium, the S1 pocket can bind both acidic and basic residues through formation of salt bridges with the charged side chains. In the presence of calcium, the binding of acidic residues is enhanced as they ligate the cation, whereas the binding of basic residues is no longer favorable due to charge repulsion. Of the peptidomimetic inhibitors of APA, amastatin has higher potency than bestatin by fitting better in the S1 pocket and interacting additionally with the S3′ subsite. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation and can guide the design and development of brain-targeting antihypertensive APA inhibitors. PMID:23888046

Structural insights into central hypertension regulation by human aminopeptidase A.

PubMed

Yang, Yang; Liu, Chang; Lin, Yi-Lun; Li, Fang

2013-08-30

Hypertension is regulated through both the central and systemic renin-angiotensin systems. In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium. Here, we determined the crystal structures of human APA and its complexes with different ligands and identified a calcium-binding site in the S1 pocket of APA. Without calcium, the S1 pocket can bind both acidic and basic residues through formation of salt bridges with the charged side chains. In the presence of calcium, the binding of acidic residues is enhanced as they ligate the cation, whereas the binding of basic residues is no longer favorable due to charge repulsion. Of the peptidomimetic inhibitors of APA, amastatin has higher potency than bestatin by fitting better in the S1 pocket and interacting additionally with the S3' subsite. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation and can guide the design and development of brain-targeting antihypertensive APA inhibitors.

Designing a community engagement framework for a new dengue control method: a case study from central Vietnam.

PubMed

McNaughton, Darlene; Duong, Thi Thu Huong

2014-05-01

The Wolbachia strategy aims to manipulate mosquito populations to make them incapable of transmitting dengue viruses between people. To test its efficacy, this strategy requires field trials. Public consultation and engagement are recognized as critical to the future success of these programs, but questions remain regarding how to proceed. This paper reports on a case study where social research was used to design a community engagement framework for a new dengue control method, at a potential release site in central Vietnam. The approach described here, draws on an anthropological methodology and uses both qualitative and quantitative methods to design an engagement framework tailored to the concerns, expectations, and socio-political setting of a potential trial release site for Wolbachia-infected Aedes aegypti mosquitoes. The process, research activities, key findings and how these were responded to are described. Safety of the method to humans and the environment was the most common and significant concern, followed by efficacy and impact on local lives. Residents expected to be fully informed and engaged about the science, the project, its safety, the release and who would be responsible should something go wrong. They desired a level of engagement that included regular updates and authorization from government and at least one member of every household at the release site. Results demonstrate that social research can provide important and reliable insights into public concerns and expectations at a potential release site, as well as guidance on how these might be addressed. Findings support the argument that using research to develop more targeted, engagement frameworks can lead to more sensitive, thorough, culturally comprehensible and therefore ethical consultation processes. This approach has now been used successfully to seek public input and eventually support for releases Wolbachia-infected mosquitoes, in two different international settings--Australia and Vietnam.

Designing a Community Engagement Framework for a New Dengue Control Method: A Case Study from Central Vietnam

PubMed Central

McNaughton, Darlene; Duong, Thi Thu Huong

2014-01-01

Background The Wolbachia strategy aims to manipulate mosquito populations to make them incapable of transmitting dengue viruses between people. To test its efficacy, this strategy requires field trials. Public consultation and engagement are recognized as critical to the future success of these programs, but questions remain regarding how to proceed. This paper reports on a case study where social research was used to design a community engagement framework for a new dengue control method, at a potential release site in central Vietnam. Methodology/Principal Findings The approach described here, draws on an anthropological methodology and uses both qualitative and quantitative methods to design an engagement framework tailored to the concerns, expectations, and socio-political setting of a potential trial release site for Wolbachia-infected Aedes aegypti mosquitoes. The process, research activities, key findings and how these were responded to are described. Safety of the method to humans and the environment was the most common and significant concern, followed by efficacy and impact on local lives. Residents expected to be fully informed and engaged about the science, the project, its safety, the release and who would be responsible should something go wrong. They desired a level of engagement that included regular updates and authorization from government and at least one member of every household at the release site. Conclusions/Significance Results demonstrate that social research can provide important and reliable insights into public concerns and expectations at a potential release site, as well as guidance on how these might be addressed. Findings support the argument that using research to develop more targeted, engagement frameworks can lead to more sensitive, thorough, culturally comprehensible and therefore ethical consultation processes. This approach has now been used successfully to seek public input and eventually support for releases Wolbachia-infected mosquitoes, in two different international settings - Australia and Vietnam. PMID:24853391

Atmospheric Radiation Measurement Program facilities newsletter, July 2000.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sisterson, D. L.; Holdridge, D. J., ed.

2000-08-03

For improved safety in and around the ARM SGP CART site, the ARM Program recently purchased and installed an aircraft detection radar system at the central facility near Lamont, Oklahoma. The new system will enhance safety measures already in place at the central facility. The SGP CART site, especially the central facility, houses several instruments employing laser technology. These instruments are designed to be eye-safe and are not a hazard to personnel at the site or pilots of low-flying aircraft over the site. However, some of the specialized equipment brought to the central facility by visiting scientists during scheduled intensivemore » observation periods (IOPs) might use higher-power laser beams that point skyward to make measurements of clouds or aerosols in the atmosphere. If these beams were to strike the eye of a person in an aircraft flying above the instrument, damage to the person's eyesight could result. During IOPs, CART site personnel have obtained Federal Aviation Administration (FAA) approval to temporarily close the airspace directly over the central facility and keep aircraft from flying into the path of the instrument's laser beam. Information about the blocked airspace is easily transmitted to commercial aircraft, but that does not guarantee that the airspace remains completely plane-free. For this reason, during IOPs in which non-eye-safe lasers were in use in the past, ARM technicians watched for low-flying aircraft in and around the airspace over the central facility. If the technicians spotted such an aircraft, they would manually trigger a safety shutter to block the laser beam's path skyward until the plane had cleared the area.« less

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

21 CFR 882.5550 - Central nervous system fluid shunt and components.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

Optimizing Ocean Space: Co-siting Open Ocean Aquaculture

NASA Astrophysics Data System (ADS)

Cobb, B. L.; Wickliffe, L. C.; Morris, J. A., Jr.

2016-12-01

In January of 2016, NOAA's National Marine Fisheries Service released the Gulf Aquaculture Plan (GAP) to manage the development of environmentally sound and economically sustainable open ocean finfish aquaculture in the Gulf of Mexico (inside the U.S. Exclusive Economic Zone [EEZ]). The GAP provides the first regulatory framework for aquaculture in federal waters with estimated production of 64 million pounds of finfish, and an estimated economic impact of $264 million annually. The Gulf of Mexico is one of the most industrialized ocean basins in the world, with many existing ocean uses including oil and natural gas production, shipping and commerce, commercial fishing operations, and many protected areas to ensure conservation of valuable ecosystem resources and services. NOAA utilized spatial planning procedures and tools identifying suitable sites for establishing aquaculture through exclusion analyses using authoritative federal and state data housed in a centralized geodatabase. Through a highly collaborative, multi-agency effort a mock permitting exercise was conducted to illustrate the regulatory decision-making process for the Gulf. Further decision-making occurred through exploring co-siting opportunities with oil and natural gas platforms. Logistical co-siting was conducted to reduce overall operational costs by looking at distance to major port and commodity tonnage at each port. Importantly, the process of co-siting allows aquaculture to be coupled with other benefits, including the availability of previously established infrastructure and the reduction of environmental impacts.

Managing Waste Inventory and License Limits at the Perma-Fix Northwest Facility to Meet CH2M Hill Plateau Remediation Company (CHPRC) American Recovery and Reinvestment Act (ARRA) Deliverables - 12335

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moak, Don J.; Grondin, Richard L.; Triner, Glen C.

CH2M Hill Plateau Remediation Company (CHRPC) is a prime contractor to the U.S. Department of Energy (DOE) focused on the largest ongoing environmental remediation project in the world at the DOE Hanford Site Central Plateau, i.e. the DOE Hanford Plateau Remediation Contract. The East Tennessee Materials and Energy Corporation (M and EC); a wholly owned subsidiary of Perma-Fix Environmental Services, Inc. (PESI), is a small business team member to CHPRC. Our scope includes project management; operation and maintenance of on-site storage, repackaging, treatment, and disposal facilities; and on-site waste management including waste receipt from generators and delivery to on-site andmore » off-site treatment, storage, and disposal facilities. As part of this scope, M and EC staffs the centralized Waste Support Services organization responsible for all waste characterization and acceptance required to support CHPRC and waste generators across the Hanford Site. At the time of the CHPRC contract award (August 2008) slightly more than 9,000 cubic meters (m{sup 3}) of legacy waste was defined as 'no-path-forward waste'. A significant portion of this waste (7,650 m{sup 3}) comprised wastes with up to 50 grams of special nuclear materials (SNM) in oversized packages recovered during retrieval operations and large glove boxes removed from the Plutonium Finishing Plant (PFP). Through a collaborative effort between the DOE, CHPRC, and Perma-Fix Environmental Services, Inc. (PESI), pathways for these problematic wastes were developed that took advantage of commercial treatment capabilities at a nearby vendor facility, Perma-Fix Northwest (PFNW). In the spring of 2009, CHPRC initiated a pilot program under which they began shipping large package, low gram suspect TRU (<15 g SNM per container), and large package contact and remote handled MLLW to the off-site PFNW facility for treatment. PFNW is restricted by the SNM limits set for the total quantity of SNM allowed at the facility in accordance with the facility's radioactive materials license(s) (RML). While both CHPRC and PFNW maintain waste databases to track all waste movements, it became evident early in the process that a tool was needed that married the two systems to better track SNM inventories and sequence waste from the point of generation, through the PFNW facility, and back to the Hanford site for final disposition. This tool, known as the Treatment Integration and Planning Tool (TIPT), has become a robust planning tool that provides real-time data to support compliant and efficient waste generation, transportation, treatment, and disposition. TIPT is developing into the next generation tool that will change the way in which legacy wastes, retrieval wastes and decontamination and decommissioning operations are conducted on the Plateau Remediation Contract (PRC). The real value of the TIPT is its predictive capability. It allows the W and FMP to map out optimal windows for processing waste through the PFNW facility, or through any process that is in some way resource limited. It allows project managers to identify and focus on problem areas before shipments are affected. It has been modified for use in broader applications to predict turnaround times and identify windows of opportunity for processing higher gram wastes through PFNW and to allow waste generators, site-wide, to accurately predict scope, cost, and schedule for waste generation to optimize processing and eliminate storage, double handling, and related costs and unnecessary safety risks. The TIPT addresses the years old problem of how to effectively predict not only what needs to be done, but when. 'When' is the key planning parameter that has been ignored by the generator and processor for many years, but has proven to be the most important parameter for both parties. While further refinement is a natural part of any development process, the current improvements on the TIPT have shown that prediction is a powerful consideration. Even in lean times expected for the foreseeable future, the improved TIPT continues to play a central role in managing our way through those times to assure facilities remain viable and available. It is recommended that other major remediation projects and waste processing facilities incorporate a tool such as TIPT to improve customer-commercial supplier communications and better optimization of resources. (authors)« less

Estimating Viscoelastic Deformation Due to Seasonal Loading

NASA Technical Reports Server (NTRS)

Sauber, Jeanne

2015-01-01

Scientists have been making summer-­-time geodetic measurements in south central Alaska for decades to estimate the rate at which a continental-­-ocean terrane is accreting to the North American continent. Southern Alaska has big earthquakes every century and large, rapidly changing glaciers. In the last decade, primarily as part of the EarthScope Plate Boundary Observatory project, continuous GPS measurements have recorded the response of sites such as the near-­-coastal geodetic site, AB35 to competing processes: uplift and movement to the northwest due to tectonic forces and the response of the solid Earth to seasonal and longer-­-term changes in the cryosphere (snow and ice) surrounding the site. Which process causes the largest displacements of the site? Figure 1 (Blewitt, Nevada Geodetic Lab, 2015) shows the Northward, Eastward, and Upward motion of AB35 between 2007 and 2015. The site is moving rapidly to the north and west reflecting the tectonic convergence of site toward interior Alaska but there is small wiggle on the North component reflecting seasonal displacements of the site associated with snow loading and unloading. However, the Up component, shows a large seasonal signal due to snow loading in the winter (down) and ice and snow melting in the warmer months (site goes up). Between 2007 and the present, the site position is slowly moving upward, due to tectonic forcing but probably associated with longer-­- term ice melting as well. We are using the CIG finite element modeling (FEM) program Pylith to estimate the surface displacements and stresses associated with seasonal loading changes (top figure and Figure 2 far right) for water year 2012, 2011.8 - 2012.8) and the longer-­-term retreat of the surrounding glaciers.

Central Venous Catheter (Central Line)

MedlinePlus

... the skin entry site. With care, central venous catheters can remain in the body for several months without becoming infected. ■ ■ Blocking or kinking— Blood clots may begin to form in the catheter but ...

Northward range expansion of Ixodes scapularis evident over a short timescale in Ontario, Canada

PubMed Central

Leighton, Patrick A.; Ogden, Nicholas H.; Lindsay, L. Robbin; Michel, Pascal; Pearl, David L.; Jardine, Claire M.

2017-01-01

The invasion of the blacklegged tick, Ixodes scapularis into Ontario, Canada poses a significant risk to public health because it is a vector for numerous pathogens, including Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease. Baseline field sampling in 2014 and 2015 detected I. scapularis and B. burgdorferi at sites across southern, eastern and central Ontario, including a hot spot in eastern Ontario. A “speed of spread” model for I. scapularis developed by Leighton and colleagues (2012) estimated that the tick’s range was expanding northward at 46 km/year. In 2016, we revisited a subset of sites sampled in 2014 and 2015 to understand the changing nature of risk, and assess whether the rate of tick invasion is consistent with the speed of spread estimate. Ticks were collected via tick dragging at 17 out of 36 sites, 5 of which were new sites for I. scapularis. Samples were positive for B. burgdorferi at 8 sites. No other I. scapularis-borne pathogens were detected. Centrographic statistics revealed an increase in the dispersion of I. scapularis positive sites in eastern Ontario. Field data for each site were then compared to the model’s predicted year of establishment for each census subdivision. Our findings illustrate that the range expansion of I. scapularis and the emergence of B. burgdorferi is ongoing, and provide short timescale evidence of the processes associated with I. scapularis spread. The range front appears to be moving at a rate of ~46 km/year, with colonization of the tick behind this range front occurring at a slower and heterogeneous rate. Assessment of site-level ecological factors did not provide any insight into the underlying processes that may be influencing the colonization of I. scapularis in specific areas. Ongoing field sampling is needed to monitor this dynamic process. This study highlights the current geographic risk associated with Lyme disease, which can be used to target public health interventions to the areas of greatest risk. PMID:29281675

Region-to-area screening methodology for the Crystalline Repository Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1985-04-01

The purpose of this document is to describe the Crystalline Repository Project's (CRP) process for region-to-area screening of exposed and near-surface crystalline rock bodies in the three regions of the conterminous United States where crystalline rock is being evaluated as a potential host for the second nuclear waste repository (i.e., in the North Central, Northeastern, and Southeastern Regions). This document indicates how the US Department of Energy's (DOE) General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories (10 CFR 960) were used to select and apply factors and variables for the region-to-area screening, explains how these factors andmore » variable are to be applied in the region-to-area screening, and indicates how this methodology relates to the decision process leading to the selection of candidate areas. A brief general discussion of the screening process from the national survey through area screening and site recommendation is presented. This discussion sets the scene for detailed discussions which follow concerning the region-to-area screening process, the guidance provided by the DOE Siting Guidelines for establishing disqualifying factors and variables for screening, and application of the disqualifying factors and variables in the screening process. This document is complementary to the regional geologic and environmental characterization reports to be issued in the summer of 1985 as final documents. These reports will contain the geologic and environmental data base that will be used in conjunction with the methodology to conduct region-to-area screening.« less

MAppERS experience: natural processes and preparedness in the societal context

NASA Astrophysics Data System (ADS)

Frigerio, Simone; Schenato, Luca; Bossi, Giulia; Mantovani, Matteo; Marcato, Gianluca; Pasuto, Alessandro

2016-04-01

Within natural processes responsibilities from central authorities to local levels as first actors of civil protection is a changing pattern. Prevention and preparedness in natural hazards are long-term goals based on capacities of professional volunteers, and improving the awareness of the citizens as local inhabitants. Local people have impacts on their lives but training and involvement towards specific techniques change their role within risk communication and emergency preparedness. A collaborative user environment is useful for emergency response and support in the wake of disasters, feeding updated information on the ground directly to on-site responders. MAppERS (Mobile Application for Emergency Response and Support) is a funded project (2013-2015 Humanitarian Aid and Civil Protection, ECHO A5) based on human role as "crowd-sourced mappers" through smart phone application able to share GPS-localised and detailed parameters. The feedback from testing and the training courses aim to raising public awareness and participation in a networked disaster response. The project implies design and test of smart phone linked with a real-time dashboard platform for rescue services citizens and volunteers of civil protection. Two pilot sites, including trainings on modules functioning control usability and quality of the product. The synchronized platform offers the activity of cloud data collection with a central data dashboard. Information is collected in a context of floods processes, with crowdsourcing action from local population, for proper awareness with own personal flood plan and long-term preparedness. A second context tested pre-emergency actions on field with rescue team, collecting state-of-art and condition of hazards.

A tale of three Brownfields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sweet, F.R.; Worthington, M.A.; Belli, E.

Contaminated site remediation and reuse, or Brownfield redevelopment, has become an increasingly important approach to site development in the northeast corridor, yet the scale of this activity is but a fraction of its full potential. The problem lies in the multi-jurisdictional quagmire that confronts a Brownfield project. Permitting such projects is an overly taxing dynamic process that has become a staple diet for adept multidisciplinary consulting firms. Limited government sanctions such as clean sites initiatives and economic revitalization zones are at best, when successful, interesting bench studies. The central hypothesis that, if regulations are streamlined then site reuse will occur,more » is sound. Yet streamlining brings concerns that the protection of public health and the environment will be compromised and that the result will be a lower standard of public protection for urban populations. The authors postulate that the permitting of Brownfield projects can be streamlined without creating a double standard of risk tolerance. The authors present evidence of this by comparing publicly and privately funded projects.« less

Predicting the Metabolic Sites by Flavin-Containing Monooxygenase on Drug Molecules Using SVM Classification on Computed Quantum Mechanics and Circular Fingerprints Molecular Descriptors

PubMed Central

Fu, Chien-wei; Lin, Thy-Hou

2017-01-01

As an important enzyme in Phase I drug metabolism, the flavin-containing monooxygenase (FMO) also metabolizes some xenobiotics with soft nucleophiles. The site of metabolism (SOM) on a molecule is the site where the metabolic reaction is exerted by an enzyme. Accurate prediction of SOMs on drug molecules will assist the search for drug leads during the optimization process. Here, some quantum mechanics features such as the condensed Fukui function and attributes from circular fingerprints (called Molprint2D) are computed and classified using the support vector machine (SVM) for predicting some potential SOMs on a series of drugs that can be metabolized by FMO enzymes. The condensed Fukui function fA− representing the nucleophilicity of central atom A and the attributes from circular fingerprints accounting the influence of neighbors on the central atom. The total number of FMO substrates and non-substrates collected in the study is 85 and they are equally divided into the training and test sets with each carrying roughly the same number of potential SOMs. However, only N-oxidation and S-oxidation features were considered in the prediction since the available C-oxidation data was scarce. In the training process, the LibSVM package of WEKA package and the option of 10-fold cross validation are employed. The prediction performance on the test set evaluated by accuracy, Matthews correlation coefficient and area under ROC curve computed are 0.829, 0.659, and 0.877 respectively. This work reveals that the SVM model built can accurately predict the potential SOMs for drug molecules that are metabolizable by the FMO enzymes. PMID:28072829

Evaluation of a low cost wireless heat ratio method system for measuring transpiration

NASA Astrophysics Data System (ADS)

Eiriksson, D.; Boyer, B.; Aishlin, P. S.; Bowling, D. R.

2016-12-01

For decades, environmental measurements in remote locations have consisted of sensors hard wired to loggers that send data to central servers via radio, satellite, or cellular telemetry. This model of data collection is effective when all sensors are located in close proximity to the central data logger, such as on a weather station. Frequently, however, in order to adequately capture the spatial heterogeneity associated with environmental processes (e.g., transpiration, soil moisture, or snow depth), it is necessary to install many sensors 10's to 100's of meters from a central data logging station. This presents a practical and financial obstacle when considering the cost of cabling and conduit, in addition to the potential data collection and data quality problems associated with long cable runs. We offer a solution to this persistent challenge with a hybrid datalogging system that combines the power and reliability of Campbell Scientific logging and telemetry equipment with low cost Xbee radios and Arduino based data logging platforms. To evaluate the promise of this hybrid datalogging concept we developed a new generation of low cost, homemade heat ratio sapflux sensors and tested them at a forested site in the Wasatch Mountains, near Salt Lake City, Utah. We present data from this test site, heat ratio method sensor construction details, and example code that merges the capabilities of Arduino and Campbell Scientific datalogging systems.

Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

PubMed Central

Finak, Greg; Langweiler, Marc; Jaimes, Maria; Malek, Mehrnoush; Taghiyar, Jafar; Korin, Yael; Raddassi, Khadir; Devine, Lesley; Obermoser, Gerlinde; Pekalski, Marcin L.; Pontikos, Nikolas; Diaz, Alain; Heck, Susanne; Villanova, Federica; Terrazzini, Nadia; Kern, Florian; Qian, Yu; Stanton, Rick; Wang, Kui; Brandes, Aaron; Ramey, John; Aghaeepour, Nima; Mosmann, Tim; Scheuermann, Richard H.; Reed, Elaine; Palucka, Karolina; Pascual, Virginia; Blomberg, Bonnie B.; Nestle, Frank; Nussenblatt, Robert B.; Brinkman, Ryan Remy; Gottardo, Raphael; Maecker, Holden; McCoy, J Philip

2016-01-01

Standardization of immunophenotyping requires careful attention to reagents, sample handling, instrument setup, and data analysis, and is essential for successful cross-study and cross-center comparison of data. Experts developed five standardized, eight-color panels for identification of major immune cell subsets in peripheral blood. These were produced as pre-configured, lyophilized, reagents in 96-well plates. We present the results of a coordinated analysis of samples across nine laboratories using these panels with standardized operating procedures (SOPs). Manual gating was performed by each site and by a central site. Automated gating algorithms were developed and tested by the FlowCAP consortium. Centralized manual gating can reduce cross-center variability, and we sought to determine whether automated methods could streamline and standardize the analysis. Within-site variability was low in all experiments, but cross-site variability was lower when central analysis was performed in comparison with site-specific analysis. It was also lower for clearly defined cell subsets than those based on dim markers and for rare populations. Automated gating was able to match the performance of central manual analysis for all tested panels, exhibiting little to no bias and comparable variability. Standardized staining, data collection, and automated gating can increase power, reduce variability, and streamline analysis for immunophenotyping. PMID:26861911

Anatomic evidence for peripheral neural processing in mammalian graviceptors

NASA Technical Reports Server (NTRS)

Ross, M. D.

1985-01-01

Ultrastructural study of utricular and saccular maculas demonstrates that their innervation patterns are complex. There is a clustering of type I and type II hair cells based upon a sharing of afferents, a system of efferent-type beaded fibers that is of intramacular (mostly calyceal) origin, and a plexus-like arrangement of afferents and efferents at many sites in the neuroepithelium. Results suggest that information concerning linear acceleration is processed peripherally, beginning at the hair cell level, before being sent to the central nervous system. The findings may supply a structural basis for peripheral adaptation to a constant stimulus, and for lateral inhibition to improve signal relative to noise.

Lunar and Planetary Science XXXV: Image Processing and Earth Observations

NASA Technical Reports Server (NTRS)

2004-01-01

The titles in this section include: 1) Expansion in Geographic Information Services for PIGWAD; 2) Modernization of the Integrated Software for Imagers and Spectrometers; 3) Science-based Region-of-Interest Image Compression; 4) Topographic Analysis with a Stereo Matching Tool Kit; 5) Central Avra Valley Storage and Recovery Project (CAVSARP) Site, Tucson, Arizona: Floodwater and Soil Moisture Investigations with Extraterrestrial Applications; 6) ASE Floodwater Classifier Development for EO-1 HYPERION Imagery; 7) Autonomous Sciencecraft Experiment (ASE) Operations on EO-1 in 2004; 8) Autonomous Vegetation Cover Scene Classification of EO-1 Hyperion Hyperspectral Data; 9) Long-Term Continental Areal Reduction Produced by Tectonic Processes.

Assessment of Loblolly Pine Decline in Central Alabama

Treesearch

Nolan J. Hess; William J. Otrosina; Emily A. Carter; Jim R. Steinman; John P. Jones; Lori G. Eckhardt; Ann M. Weber; Charles H. Walkinshaw

2002-01-01

Loblolly pine (Pinus taeda L.) decline has been prevalent on upland sites of central Alabama since the 1960's. The purpose of this study was to compare Forest Health Monitoring (FHM) standards and protocols with root health evaluations relative to crown, stem, and site measurements. Thirty-nine 1/6 acre plots were established on loblolly decline...

Ethanol-Fed Or Solid-Phase Organic Sulfate Reducing Bioreactors For The National Tunnel Drainage, Clear Creek/Central City Superfund Site (Presentation)

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is planning to treat mining influenced water (MIW) from the National Tunnel Adit that discharges to North Clear Creek near the City of Blackhawk, Colorado. North Clear Creek is part of the Clear Creek/Central City Superfund Site, an...

Ethanol-Fed Or Solid-Phase Organic Sulfate Reducing Bioreactors For The National Tunnel Drainage, Clear Creek/Central City Superfund Site

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is planning to treat mining influenced water (MIW) from the National Tunnel Adit that discharges to North Clear Creek near the City of Blackhawk, Colorado. North Clear Creek is part of the Clear Creek/Central City Superfund Site, an...

Biomass and nutrient distributions in central Oregon second-growth ponderosa pine ecosystems.

Treesearch

Susan N. Little; Lauri J. Shainsky

1995-01-01

We investigated the distribution of biomass and nutrients in second-growth ponderosa pine (Pinus ponderosa Dougl. ex Laws.) ecosystems in central Oregon. Destructive sampling of aboveground and belowground tree biomass was carried out at six sites in the Deschutes National Forest; three of these sites also were intensively sampled for biomass and...

2011 Annual Wastewater Reuse Report for the Idaho National Laboratory Site’s Central Facilities Area Sewage Treatment Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael G. Lewis

2012-02-01

This report describes conditions, as required by the state of Idaho Wastewater Reuse Permit (LA-000141-03), for the wastewater land application site at Idaho National Laboratory Site's Central Facilities Area Sewage Treatment Plant from November 1, 2010, through October 31, 2011. The report contains the following information: (1) Site description; (2) Facility and system description; (3) Permit required monitoring data and loading rates; (4) Status of special compliance conditions and activities; and (5) Discussion of the facility's environmental impacts. During the 2011 permit year, approximately 1.22 million gallons of treated wastewater was land-applied to the irrigation area at Central Facilities Areamore » Sewage Treatment plant.« less

Microearthquake networks and earthquake prediction

USGS Publications Warehouse

Lee, W.H.K.; Steward, S. W.

1979-01-01

A microearthquake network is a group of highly sensitive seismographic stations designed primarily to record local earthquakes of magnitudes less than 3. Depending on the application, a microearthquake network will consist of several stations or as many as a few hundred . They are usually classified as either permanent or temporary. In a permanent network, the seismic signal from each is telemetered to a central recording site to cut down on the operating costs and to allow more efficient and up-to-date processing of the data. However, telemetering can restrict the location sites because of the line-of-site requirement for radio transmission or the need for telephone lines. Temporary networks are designed to be extremely portable and completely self-contained so that they can be very quickly deployed. They are most valuable for recording aftershocks of a major earthquake or for studies in remote areas.  

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair.

PubMed

Lu, Wei-Ting; Hawley, Ben R; Skalka, George L; Baldock, Robert A; Smith, Ewan M; Bader, Aldo S; Malewicz, Michal; Watts, Felicity Z; Wilczynska, Ania; Bushell, Martin

2018-02-07

The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood. Here, we show that miRNA biogenesis enzymes, Drosha and Dicer, control the recruitment of repair factors from multiple pathways to sites of damage. Depletion of Drosha significantly reduces DNA repair by both homologous recombination (HR) and non-homologous end joining (NHEJ). Drosha is required within minutes of break induction, suggesting a central and early role for RNA processing in DNA repair. Sequencing of DNA:RNA hybrids reveals RNA invasion around DNA break sites in a Drosha-dependent manner. Removal of the RNA component of these structures results in impaired repair. These results show how RNA can be a direct and critical mediator of DNA damage repair in human cells.

Correlation of surface site formation to nanoisland growth in the electrochemical roughening of Pt(111)

NASA Astrophysics Data System (ADS)

Jacobse, Leon; Huang, Yi-Fan; Koper, Marc T. M.; Rost, Marcel J.

2018-03-01

Platinum plays a central role in a variety of electrochemical devices and its practical use depends on the prevention of electrode degradation. However, understanding the underlying atomic processes under conditions of repeated oxidation and reduction inducing irreversible surface structure changes has proved challenging. Here, we examine the correlation between the evolution of the electrochemical signal of Pt(111) and its surface roughening by simultaneously performing cyclic voltammetry and in situ electrochemical scanning tunnelling microscopy (EC-STM). We identify a `nucleation and early growth' regime of nanoisland formation, and a `late growth' regime after island coalescence, which continues up to at least 170 cycles. The correlation analysis shows that each step site that is created in the `late growth' regime contributes equally strongly to both the electrochemical and the roughness evolution. In contrast, in the `nucleation and early growth' regime, created step sites contribute to the roughness, but not to the electrochemical signal.

Immediate propagation of deglacial environmental change to turbidite systems along the Chilean continental slope

NASA Astrophysics Data System (ADS)

Bernhardt, Anne; Schwanghart, Wolfgang; Hebbeln, Dierk; Stuut, Jan-Berend; Strecker, Manfred

2017-04-01

Understanding how Earth-surface processes respond to past climatic perturbations is crucial for making informed predictions about future impacts of climate change on sediment fluxes. Sedimentary records provide the archives for inferring these processes but their interpretation is compromised by our incomplete understanding of how sediment-routing systems respond to millennial-scale climate cycles. We analyzed seven sediment cores recovered from turbidite depositional sites along the continental slope of the Chile convergent margin. These depositional systems represent the ultimate sedimentary archives before sediment gets recycled during subduction processes and provide relatively continuous and well-dated records. The study sites span a pronounced arid-to-humid gradient with variable topographic gradients and related connectivity of terrestrial and marine landscapes on the continental slope. This setting allowed us to study event-related depositional processes from the Last Glacial Maximum to present in different climatic and geomorphic settings. The turbidite record was quantified in terms of turbidite thickness and frequency. The three studied sites show a steep decline of turbidite deposition during deglaciation. High rates of sea-level rise significantly lag the decline in turbidite deposition by 3-6.5 kyrs. However, comparison to paleoclimate proxies shows that this spatio-temporal sedimentary pattern mirrors the deglacial humidity decrease and concomitant warming with little to no lag times. Our results suggest that the deglacial humidity decrease resulted in a decrease of fluvial sediment supply, which propagated rapidly through the highly connected systems into the marine sink in north-central Chile. In contrast, in south-central Chilean systems, connectivity between the Andean erosional zone and the fluvial transfer zone probably decreased abruptly by the deglaciation of piedmont lakes, resulting in a significant and rapid decrease of sediment supply to the ocean. Additionally, reduced moisture supply may have also contributed to the rapid decline of turbidite deposition. These different causes result in similar depositional patterns in the marine sinks. We conclude that turbiditic strata can act as reliable recorders of climate change across a wide range of climatic zones and geomorphic conditions. However, the underlying causes for similar signal manifestations in the sinks may differ, ranging from maintained high system connectivity to abrupt connectivity loss.

SITE CHARACTERIZATION LIBRARY VERSION 3.0

EPA Science Inventory

The Site Characterization Library is a CD that provides a centralized, field-portable source for site characterization information. Version 3 of the Site Characterization Library contains additional (from earlier versions) electronic documents and computer programs related to th...

Environmental Impact Analysis Process. Environmental Impact Statement Proposed Sites Central Radar System Over-the-Horizon Backscatter Radar Program

DTIC Science & Technology

1990-08-01

laying in beds or layers 3 Subspecies A geographical or ecological subdivision of a species Switch reflectors Passive antennas that will reflect CRS...that provide ecological and economic benefits. They furnish water and habitat for waterfowl and other wildlife and water for crops and livestock...ridge areas of I glacial Lake Agassiz, which were preferred for various reasons such as the ecological diversity or the ability to survey lower ground

Environmental Impact Analysis Process. Draft Environmental Impact Statement Proposed Central Radar System Over-the-Horizon Backscatter Radar Program

DTIC Science & Technology

1986-08-01

demand for food crops and high crop yields in the region, drew a great influx of people. North Dakota and South Dakota were admitted to the Union in 1889...aircraft costs approximately $135 million. The cost to purchase, man, base, and operate the large number of aircraft required to match the proposed OTH-B...identified. Possible sites of historical significance indicated by Tweton (1978) are the Tara Settlement Post Office, the Rugby Post Office, and the

KSC-04PD-0251

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. NASA Administrator Sean OKeefe (center) listens to Congressman Tom Feeney (second from left) during a tour of the Central Florida Research Park, near Orlando. At right is U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the new NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

KSC-04PD-0253

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. KSC Director Jim Kennedy (center) makes a presentation to NASA and other officials about the benefits of locating NASAs new Shared Services Center in the Central Florida Research Park, near Orlando. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Evaluating Contaminant Flux from the Vadose Zone to the Groundwater in the Hanford Central Plateau. SX Tank Farms Case Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Truex, Michael J.; Oostrom, Martinus; Last, George V.

At the DOE Hanford Site, contaminants were discharged to the subsurface through engineered waste sites in the Hanford Central Plateau. Additional waste was released through waste storage tank leaks. Much of the contaminant inventory is still present within the unsaturated vadose zone sediments. The nature and extent of future groundwater contaminant plumes and the growth or decline of current groundwater plumes beneath the Hanford Central Plateau are a function of the contaminant flux from the vadose zone to the groundwater. In general, contaminant transport is slow through the vadose zone and it is difficult to directly measure contaminant flux inmore » the vadose zone. Predictive analysis, supported by site characterization and monitoring data, was applied using a structured, systems-based approach to estimate the future contaminant flux to groundwater in support of remediation decisions for the vadose zone and groundwater (Truex and Carroll 2013). The SX Tank Farm was used as a case study because of the existing contaminant inventory in the vadose zone, observations of elevated moisture content in portions of the vadose zone, presence of a limited-extent groundwater plume, and the relatively large amount and wide variety of data available for the site. Although the SX Tank Farm case study is most representative of conditions at tank farm sites, the study has elements that are also relevant to other types of disposal sites in the Hanford Central Plateau.« less

Biogeochemical Cycling and Environmental Stability of Pu Relevant to Long-Term Stewardship of DOE Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santschi, Peter H.

2006-06-01

The overall objective of this proposed research is to understand the biogeochemical cycling of Pu in environments of interest to long-term DOE stewardship issues. Central to Pu cycling (transport initiation to immobilization) is the role of microorganisms. The hypothesis underlying this proposal is that microbial activity is the causative agent in initiating the mobilization of Pu in near-surface environments: through the transformation of Pu associated with solid phases, production of extracellular polymeric substances (EPS) carrier phases, and the creation of microenvironments. Also, microbial processes are central to the immobilization of Pu species, through the metabolism of organically complexed Pu speciesmore » and Pu associated with extracellular carrier phases and the creation of environments favorable for Pu transport retardation.« less

Tracking the Short Term Planning (STP) Development Process

NASA Technical Reports Server (NTRS)

Price, Melanie; Moore, Alexander

2010-01-01

Part of the National Aeronautics and Space Administration?s mission is to pioneer the future in space exploration, scientific discovery and aeronautics research is enhanced by discovering new scientific tools to improve life on earth. Sequentially, to successfully explore the unknown, there has to be a planning process that organizes certain events in the right priority. Therefore, the planning support team has to continually improve their processes so the ISS Mission Operations can operate smoothly and effectively. The planning support team consists of people in the Long Range Planning area that develop timelines that includes International Partner?s Preliminary STP inputs all the way through to publishing of the Final STP. Planning is a crucial part of the NASA community when it comes to planning the astronaut?s daily schedule in great detail. The STP Process is in need of improvement, because of the various tasks that are required to be broken down in order to get the overall objective of developing a Final STP done correctly. Then a new project came along in order to store various data in a more efficient database. "The SharePoint site is a Web site that provides a central storage and collaboration space for documents, information, and ideas."

Climate forcing due to the 8200 cal yr BP event observed at Early Neolithic sites in the eastern Mediterranean

NASA Astrophysics Data System (ADS)

Weninger, Bernhard; Alram-Stern, Eva; Bauer, Eva; Clare, Lee; Danzeglocke, Uwe; Jöris, Olaf; Kubatzki, Claudia; Rollefson, Gary; Todorova, Henrieta; van Andel, Tjeerd

2006-11-01

We explore the hypothesis that the abrupt drainage of Laurentide lakes and associated rapid switch of the North Atlantic thermohaline circulation 8200 yr ago had a catastrophic influence on Neolithic civilisation in large parts of southeastern Europe, Anatolia, Cyprus, and the Near East. The event at 8200 cal yr BP is observed in a large number of high-resolution climate proxies in the Northern Hemisphere, and in many cases corresponds to markedly cold and arid conditions. We identify the relevant archaeological levels of major Neolithic settlements in Central Anatolia, Cyprus, Greece and Bulgaria, and examine published stratigraphic, architectural, cultural and geoarchaeological studies for these sites. The specific archaeological events and processes we observe at a number of these sites during the study interval 8400-8000 cal yr BP lead us to refine some previously established Neolithisation models. The introduction of farming to South-East Europe occurs in all study regions (Thrace, Macedonia, Thessaly, Bulgaria) near 8200 cal yr BP. We observe major disruptions of Neolithic cultures in the Levant, North Syria, South-East Anatolia, Central Anatolia and Cyprus, at the same time. We conclude that the 8200 cal yr BP aridity event triggered the spread of early farmers, by different routes, out of West Asia and the Near East into Greece and Bulgaria.

Personal exposure to particulate matter in commuters using different transport modes (bus, bicycle, car and subway) in an assigned route in downtown Santiago, Chile.

PubMed

Suárez, Liliana; Mesías, Stephanie; Iglesias, Verónica; Silva, Claudio; Cáceres, Dante D; Ruiz-Rudolph, Pablo

2014-05-01

The objective of this study was to compare personal exposure to particulate matter (fine and ultrafine particles) in commuters using different transport modes (bicycle, bus, car and subway) in a busy, assigned route in downtown Santiago, Chile. Volunteers carrying personal samplers completed scheduled commutes during the morning rush hours, while central site measurements were conducted in parallel. A total of 137 valid commutes were assessed. The impact of central site, traffic and other variables was explored with regression models. PM2.5 personal concentrations were equal to or slightly above central site measurements, while UFP personal concentrations were above them. Regression models showed impacts of both background levels and traffic emissions on personal PM2.5 and UFP exposure. Traffic impacts varied with transport modes. Estimates of traffic impacts on personal PM2.5 exposure were 2.0, 13.0, 16.9 and 17.5 μg m(-3), for car, bicycle, subway and bus, respectively; while for UFP exposure were 8400, 16 200, 25 600 and 30 100 counts per cm(3), for subway, car, bicycle and bus, respectively. After controlling the central site and transport mode, higher temperatures increased PM2.5 exposure and decreased UFP ones, while the wind direction affected UFP personal exposure. In conclusion, we found significant impacts of both central site background measurements and traffic emissions on personal exposure of volunteer commuters in an assigned route in Santiago, with impacts varying with transport modes.

Coupled Gravity and Elevation Measurements of Ice Sheet Mass Change

NASA Technical Reports Server (NTRS)

Jezek, K. C.

2005-01-01

We measured surface gravity and position at ten locations about two glaciological measurement networks located on the South-central Greenland Ice during June 2004. Six of the individual sites of the first network were occupied the previous year. At the repeat sites we were able to measure annual accumulation rate and surface displacement by referencing measurements to aluminum poles left in the firn the previous year. We occupied 4 additional sites at a second measurement network for the first time since initial observations were last made at the network in 1981. At each individual site, we operated a GPS unit for 90 minutes - the unit was operated simultaneously with a base station unit in Sondrestrom Fjord so as to enable differential, post-processing of the data. We installed an aluminum, accumulation-rate-pole at each site. The base section of the pole also served as the mount for the GPS antenna. A new, Scintrex gravimeter was used at each site and relative gravity measurements were tied to the network of absolute gravity stations in Sondrestrom. We measured snow physical properties in two shallow pits. This report summarizes our observations and data analysis.

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites

PubMed Central

Kato, Takamitsu A.; Suzuki, Takehiro; Dohmae, Naoshi; Takizawa, Kazuya; Nakazawa, Yuka; Genet, Matthew D.; Saotome, Mika; Hama, Michio; Nakajima, Nakako Izumi; Hazawa, Masaharu; Tomita, Masanori; Koike, Manabu; Noshiro, Katsuko; Tomiyama, Kenichi; Obara, Chizuka; Gotoh, Takaya; Ui, Ayako; Fujimori, Akira; Nakayama, Fumiaki; Sugasawa, Kaoru; Okayasu, Ryuichi; Tajima, Katsushi

2018-01-01

The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the chromatin structure and DNA repair process. Whether p300/CBP at DSB sites also acetylate non-histone proteins, and how their acetylation affects DSB repair, remain unknown. Here we show that p300/CBP acetylate RAD52, a human homologous recombination (HR) DNA repair protein, at DSB sites. Using in vitro acetylated RAD52, we identified 13 potential acetylation sites in RAD52 by a mass spectrometry analysis. An immunofluorescence microscopy analysis revealed that RAD52 acetylation at DSBs sites is counteracted by SIRT2- and SIRT3-mediated deacetylation, and that non-acetylated RAD52 initially accumulates at DSB sites, but dissociates prematurely from them. In the absence of RAD52 acetylation, RAD51, which plays a central role in HR, also dissociates prematurely from DSB sites, and hence HR is impaired. Furthermore, inhibition of ataxia telangiectasia mutated (ATM) protein by siRNA or inhibitor treatment demonstrated that the acetylation of RAD52 at DSB sites is dependent on the ATM protein kinase activity, through the formation of RAD52, p300/CBP, SIRT2, and SIRT3 foci at DSB sites. Our findings clarify the importance of RAD52 acetylation in HR and its underlying mechanism. PMID:29590107

Stereo photo series for quantifying cerrado fuels in Central Brazil—volume I.

Treesearch

R.D. Ottmar; R.E. Vihnanek; H.S. Miranda; M.N. Sata; S.M. Andrade

2001-01-01

The first volume of the Cerrado photo series is a collection of sites that represent a range of physiognomic forms of the Cerrado in central Brazil including campo limpo, campo sujo, cerrado ralo, cerrado sensu stricto, and cerrado denso. Sites include wide-angle and stereo pair photographs supplemented with information on living and dead fuels,...

Spatial and temporal seed dispersal of squarrose knapweed (Centaurea virgata Lam. ssp. squarrosa (Willd.) Gugler) in west central Utah, a case study

Treesearch

Scott L. Jensen; Stephen B. Monsen; Pat Fosse

2008-01-01

This case study documents temporal and spatial squarrose knapweed (Centaurea virgata Lam. spp. squarrosa (Willd.) Gugler) seed dispersal from study sites in central Utah. Felt seed traps were placed along transects extending from sites occupied by squarrose knapweed into adjacent plant communities. Seed dispersal from knapweed...

Spatial and temporal genetic analyses reveal high gene flow among European corn borer (Lepidoptera: Crambidae) populations across the central U.S. cornbelt

EPA Science Inventory

European corn borer, Ostrinia nubilalis (Hubner), adults were sampled at 13 sites along two perpendicular 720-km transects intersecting in central Iowa, and for the following two generations at four of the same sites separated by 240-km in the cardinal directions. More than 50 mo...

40 CFR Table C-5 to Subpart C of... - Summary of Comparability Field Testing Campaign Site and Seasonal Requirements for Class II and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Angeles basin or California Central Valley Western city such as Denver, Salt Lake City, or Albuquerque Midwestern city Northeastern or mid-Atlantic city. Test site characteristics Relatively high PM2.5, nitrates... area Los Angeles basin or California Central Valley Western city such as Las Vegas or Phoenix...

Geomorphological palaeoenvironments of the Sneeuberg Range, Great Karoo, South Africa

NASA Astrophysics Data System (ADS)

Holmes, P. J.; Boardman, J.; Parsons, A. J.; Marker, M. E.

2003-12-01

Sedimentary sequences within headwater valleys on the landward side of the Great Escarpment of South Africa are elucidated and their significance as indicators of environmental change is assessed. This study focuses on the Sneeuberg Range, the most prominent mountain range in the semi-arid central Great Karoo. Valley fills of a hitherto unrecognised complexity and of a greater age than any previously recorded in the central Great Karoo are reported. Three phases of deposition spanning the Late Pleistocene up to the present are documented from sites where gully erosion has incised the valley fills. The earliest depositional phase is represented by deeply weathered, calcretised gravel deposits, which probably were emplaced by debris flow and fluvial processes in the form of a fan. These deposits subsequently were buried by finer grained, largely unconsolidated sediment, with much of this emplacement occurring during the Holocene. There is evidence for phases of landscape stability and instability within this facies. Finally, sheetwash has removed fine-grained sediments from valley flanks and has deposited it either on valley bottoms, or in presently active gullies. This process appears to be ongoing, and is the subject of current investigation. The sedimentary deposits are interpreted as representing a wide range of palaeoenvironmental conditions that have prevailed within the central Great Karoo since the penultimate glaciation. Copyright

Challenges for creating a site-specific groundwater-use record for the Ozark Plateaus aquifer system (central USA) from 1900 to 2010

NASA Astrophysics Data System (ADS)

Knierim, Katherine J.; Nottmeier, Anna M.; Worland, Scott; Westerman, Drew A.; Clark, Brian R.

2017-09-01

Hydrologic budgets to determine groundwater availability are important tools for water-resource managers. One challenging component for developing hydrologic budgets is quantifying water use through time because historical and site-specific water-use data can be sparse or poorly documented. This research developed a groundwater-use record for the Ozark Plateaus aquifer system (central USA) from 1900 to 2010 that related county-level aggregated water-use data to site-specific well locations and aquifer units. A simple population-based linear model, constrained to 0 million liters per day in 1900, provided the best means to extrapolate groundwater-withdrawal rates pre-1950s when there was a paucity of water-use data. To disaggregate county-level data to individual wells across a regional aquifer system, a programmatic hierarchical process was developed, based on the level of confidence that a well pumped groundwater for a specific use during a specific year. Statistical models tested on a subset of the best-available site-specific water-use data provided a mechanism to bracket historic groundwater use, such that groundwater-withdrawal rates ranged, on average, plus or minus 38% from modeled values. Groundwater withdrawn for public supply and domestic use accounted for between 48 and 74% of total groundwater use since 1901, highlighting that groundwater provides an important drinking-water resource. The compilation, analysis, and spatial and temporal extrapolation of water-use data remain a challenging task for water scientists, but is of paramount importance to better quantify groundwater use and availability.

Faster, efficient and secure collection of research images: the utilization of cloud technology to expand the OMI-DB

NASA Astrophysics Data System (ADS)

Patel, M. N.; Young, K.; Halling-Brown, M. D.

2018-03-01

The demand for medical images for research is ever increasing owing to the rapid rise in novel machine learning approaches for early detection and diagnosis. The OPTIMAM Medical Image Database (OMI-DB)1,2 was created to provide a centralized, fully annotated dataset for research. The database contains both processed and unprocessed images, associated data, annotations and expert-determined ground truths. Since the inception of the database in early 2011, the volume of images and associated data collected has dramatically increased owing to automation of the collection pipeline and inclusion of new sites. Currently, these data are stored at each respective collection site and synced periodically to a central store. This leads to a large data footprint at each site, requiring large physical onsite storage, which is expensive. Here, we propose an update to the OMI-DB collection system, whereby the storage of all the data is automatically transferred to the cloud on collection. This change in the data collection paradigm reduces the reliance of physical servers at each site; allows greater scope for future expansion; and removes the need for dedicated backups and improves security. Moreover, with the number of applications to access the data increasing rapidly with the maturity of the dataset cloud technology facilities faster sharing of data and better auditing of data access. Such updates, although may sound trivial; require substantial modification to the existing pipeline to ensure data integrity and security compliance. Here, we describe the extensions to the OMI-DB collection pipeline and discuss the relative merits of the new system.

Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

PubMed

Hogg, Matthew; Seki, Mineaki; Wood, Richard D; Doublié, Sylvie; Wallace, Susan S

2011-01-21

DNA polymerase θ (POLQ, polθ) is a large, multidomain DNA polymerase encoded in higher eukaryotic genomes. It is important for maintaining genetic stability in cells and helping protect cells from DNA damage caused by ionizing radiation. POLQ contains an N-terminal helicase-like domain, a large central domain of indeterminate function, and a C-terminal polymerase domain with sequence similarity to the A-family of DNA polymerases. The enzyme has several unique properties, including low fidelity and the ability to insert and extend past abasic sites and thymine glycol lesions. It is not known whether the abasic site bypass activity is an intrinsic property of the polymerase domain or whether helicase activity is also required. Three "insertion" sequence elements present in POLQ are not found in any other A-family DNA polymerase, and it has been proposed that they may lend some unique properties to POLQ. Here, we analyzed the activity of the DNA polymerase in the absence of each sequence insertion. We found that the pol domain is capable of highly efficient bypass of abasic sites in the absence of the helicase-like or central domains. Insertion 1 increases the processivity of the polymerase but has little, if any, bearing on the translesion synthesis properties of the enzyme. However, removal of insertions 2 and 3 reduces activity on undamaged DNA and completely abrogates the ability of the enzyme to bypass abasic sites or thymine glycol lesions. Copyright © 2010 Elsevier Ltd. All rights reserved.

Challenges for creating a site-specific groundwater-use record for the Ozark Plateaus aquifer system (central USA) from 1900 to 2010

USGS Publications Warehouse

Knierim, Katherine J.; Nottmeier, Anna M.; Worland, Scott C.; Westerman, Drew A.; Clark, Brian R.

2017-01-01

Hydrologic budgets to determine groundwater availability are important tools for water-resource managers. One challenging component for developing hydrologic budgets is quantifying water use through time because historical and site-specific water-use data can be sparse or poorly documented. This research developed a groundwater-use record for the Ozark Plateaus aquifer system (central USA) from 1900 to 2010 that related county-level aggregated water-use data to site-specific well locations and aquifer units. A simple population-based linear model, constrained to 0 million liters per day in 1900, provided the best means to extrapolate groundwater-withdrawal rates pre-1950s when there was a paucity of water-use data. To disaggregate county-level data to individual wells across a regional aquifer system, a programmatic hierarchical process was developed, based on the level of confidence that a well pumped groundwater for a specific use during a specific year. Statistical models tested on a subset of the best-available site-specific water-use data provided a mechanism to bracket historic groundwater use, such that groundwater-withdrawal rates ranged, on average, plus or minus 38% from modeled values. Groundwater withdrawn for public supply and domestic use accounted for between 48 and 74% of total groundwater use since 1901, highlighting that groundwater provides an important drinking-water resource. The compilation, analysis, and spatial and temporal extrapolation of water-use data remain a challenging task for water scientists, but is of paramount importance to better quantify groundwater use and availability.

Dating Caral, a preceramic site in the Supe Valley on the central coast of Peru.

PubMed

Solis, R S; Haas, J; Creamer, W

2001-04-27

Radiocarbon dates from the site of Caral in the Supe Valley of Peru indicate that monumental corporate architecture, urban settlement, and irrigation agriculture began in the Americas by 4090 years before the present (2627 calibrated years B.C.) to 3640 years before the present (1977 calibrated years B.C.). Caral is located 23 kilometers inland from the Pacific coast and contains a central zone of monumental, residential, and nonresidential architecture covering an area of 65 hectares. Caral is one of 18 large preceramic sites in the Supe Valley.

Implementing Site-based Budgeting.

ERIC Educational Resources Information Center

Sielke, Catherine C.

2001-01-01

Discusses five questions that must be answered before implementing site-based budgeting: Why are we doing this? What budgeting decisions will be devolved to the school site? How do dollars flow from the central office to the site? Who will be involved at the site? How will accountability be achieved? (Author/PKP)

Statecraft and expansionary dynamics: A Virú outpost at Huaca Prieta, Chicama Valley, Peru

PubMed Central

Millaire, Jean-François; Prieto, Gabriel; Surette, Flannery; Redmond, Elsa M.; Spencer, Charles S.

2016-01-01

Interpolity interaction and regional control were central features of all early state societies, taking the form of trade—embedded in political processes to varying degrees—or interregional conquest strategies meant to expand the polity’s control or influence over neighboring territories. Cross-cultural analyses of early statecraft suggest that territorial expansion was an integral part of the process of primary state formation, closely associated with the delegation of authority to subordinate administrators and the construction of core outposts of the state in foreign territories. We report here on a potential case of a core outpost, associated with the early Virú state, at the site of Huaca Prieta in the Chicama Valley, located 75 km north of the Virú state heartland on the north coast of Peru. This site is discussed in the context of other possible Virú outposts in the Moche Valley, Pampa La Cruz, and Huaca Las Estrellas, and as part of a broader reflection on expansionary dynamics and statecraft. PMID:27671633

Statecraft and expansionary dynamics: A Virú outpost at Huaca Prieta, Chicama Valley, Peru.

PubMed

Millaire, Jean-François; Prieto, Gabriel; Surette, Flannery; Redmond, Elsa M; Spencer, Charles S

2016-10-11

Interpolity interaction and regional control were central features of all early state societies, taking the form of trade-embedded in political processes to varying degrees-or interregional conquest strategies meant to expand the polity's control or influence over neighboring territories. Cross-cultural analyses of early statecraft suggest that territorial expansion was an integral part of the process of primary state formation, closely associated with the delegation of authority to subordinate administrators and the construction of core outposts of the state in foreign territories. We report here on a potential case of a core outpost, associated with the early Virú state, at the site of Huaca Prieta in the Chicama Valley, located 75 km north of the Virú state heartland on the north coast of Peru. This site is discussed in the context of other possible Virú outposts in the Moche Valley, Pampa La Cruz, and Huaca Las Estrellas, and as part of a broader reflection on expansionary dynamics and statecraft.

Minimizing human error in radiopharmaceutical preparation and administration via a bar code-enhanced nuclear pharmacy management system.

PubMed

Hakala, John L; Hung, Joseph C; Mosman, Elton A

2012-09-01

The objective of this project was to ensure correct radiopharmaceutical administration through the use of a bar code system that links patient and drug profiles with on-site information management systems. This new combined system would minimize the amount of manual human manipulation, which has proven to be a primary source of error. The most common reason for dosing errors is improper patient identification when a dose is obtained from the nuclear pharmacy or when a dose is administered. A standardized electronic transfer of information from radiopharmaceutical preparation to injection will further reduce the risk of misadministration. Value stream maps showing the flow of the patient dose information, as well as potential points of human error, were developed. Next, a future-state map was created that included proposed corrections for the most common critical sites of error. Transitioning the current process to the future state will require solutions that address these sites. To optimize the future-state process, a bar code system that links the on-site radiology management system with the nuclear pharmacy management system was proposed. A bar-coded wristband connects the patient directly to the electronic information systems. The bar code-enhanced process linking the patient dose with the electronic information reduces the number of crucial points for human error and provides a framework to ensure that the prepared dose reaches the correct patient. Although the proposed flowchart is designed for a site with an in-house central nuclear pharmacy, much of the framework could be applied by nuclear medicine facilities using unit doses. An electronic connection between information management systems to allow the tracking of a radiopharmaceutical from preparation to administration can be a useful tool in preventing the mistakes that are an unfortunate reality for any facility.

Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience.

PubMed

Zielinski, Stephanie M; Viveiros, Helena; Heetveld, Martin J; Swiontkowski, Marc F; Bhandari, Mohit; Patka, Peter; Van Lieshout, Esther M M

2012-01-08

Surgeons in the Netherlands, Canada and the US participate in the FAITH trial (Fixation using Alternative Implants for the Treatment of Hip fractures). Dutch sites are managed and visited by a financed central trial coordinator, whereas most Canadian and US sites have local study coordinators and receive per patient payment. This study was aimed to assess how these different trial management strategies affected trial performance. Details related to obtaining ethics approval, time to trial start-up, inclusion, and percentage completed follow-ups were collected for each trial site and compared. Pre-trial screening data were compared with actual inclusion rates. Median trial start-up ranged from 41 days (P25-P75 10-139) in the Netherlands to 232 days (P25-P75 98-423) in Canada (p = 0.027). The inclusion rate was highest in the Netherlands; median 1.03 patients (P25-P75 0.43-2.21) per site per month, representing 34.4% of the total eligible population. It was lowest in Canada; 0.14 inclusions (P25-P75 0.00-0.28), representing 3.9% of eligible patients (p < 0.001). The percentage completed follow-ups was 83% for Canadian and Dutch sites and 70% for US sites (p = 0.217). In this trial, a central financed trial coordinator to manage all trial related tasks in participating sites resulted in better trial progression and a similar follow-up. It is therefore a suitable alternative for appointing these tasks to local research assistants. The central coordinator approach can enable smaller regional hospitals to participate in multicenter randomized controlled trials. Circumstances such as available budget, sample size, and geographical area should however be taken into account when choosing a management strategy. ClinicalTrials.gov: NCT00761813.

Lg attenuation, frequency dependence and relative site response of the western United States as revealed by the EarthScope Transportable Array

NASA Astrophysics Data System (ADS)

Gallegos, Andrea; Ranasinghe, Nishath; Ni, James; Sandvol, Eric

2017-06-01

Lg attenuation of the western United States is estimated using regional waveforms recorded by EarthScope's Transportable Array, the Berkeley Digital Seismograph Network and the Caltech Regional Seismic Network. Lg attenuation is determined using the two-station method (TSM). 292 events ranging from magnitude 4 to 6.5 in a time range for the years between 2005 and 2010 are used. We have tomographically mapped variations in effective Lg Q at narrow bands with central frequencies of 0.5, 1, 2 and 3 Hz. The relative site responses of individual stations are determined using a reverse TSM at these central frequencies. Both the two-station and reverse TSMs have the advantage of effectively removing site and source effects without requiring a priori models while mapping lateral heterogeneities in the crust. Regions of high attenuation are found along the Snake River Plain, along the northern California-Oregon border, throughout the Basin and Range, Walker Lane, Wasatch Fault and the Rio Grande Rift. Regions of low attenuation are found in the Colorado Plateau, Rocky Mountains, central Nevada and the Columbia Plateau. Overall, Lg Q was found to have a power-law frequency dependence, with an increase in central frequency resulting in an increase in Q. Relative site responses were found to vary strongly with local geology. Hard rock areas such as the Sierra Nevada Mountains and the Snake River Plain show a consistent pattern of negative site response (i.e. deamplification), while areas with a higher degree of sediments, such as the grabens of the Basin and Range, show positive site response (i.e. amplification). Finally, site responses were found to vary with frequency, becoming less variable and more pronounced as frequency increases.

Comparison of risk-based decision-support systems for brownfield site rehabilitation: DESYRE and SADA applied to a Romanian case study.

PubMed

Stezar, I C; Pizzol, L; Critto, A; Ozunu, A; Marcomini, A

2013-12-15

Brownfield rehabilitation is an essential step for sustainable land-use planning and management in the European Union. In brownfield regeneration processes, the legacy contamination plays a significant role, firstly because of the persistent contaminants in soil or groundwater which extends the existing hazards and risks well into the future; and secondly, problems from historical contamination are often more difficult to manage than contamination caused by new activities. Due to the complexity associated with the management of brownfield site rehabilitation, Decision Support Systems (DSSs) have been developed to support problem holders and stakeholders in the decision-making process encompassing all phases of the rehabilitation. This paper presents a comparative study between two DSSs, namely SADA (Spatial Analysis and Decision Assistance) and DESYRE (Decision Support System for the Requalification of Contaminated Sites), with the main objective of showing the benefits of using DSSs to introduce and process data and then to disseminate results to different stakeholders involved in the decision-making process. For this purpose, a former car manufacturing plant located in the Brasov area, Central Romania, contaminated chiefly by heavy metals and total petroleum hydrocarbons, has been selected as a case study to apply the two examined DSSs. Major results presented here concern the analysis of the functionalities of the two DSSs in order to identify similarities, differences and complementarities and, thus, to provide an indication of the most suitable integration options. Copyright © 2013 Elsevier Ltd. All rights reserved.

Influence of Human Activity Patterns, particle composition, and residential air exchange rates on modeled distributions of PM 2.5 exposure compared with central-site monitoring data

EPA Science Inventory

Central-site monitors do not account for factors such as outdoor-to-indoor transport and human activity patterns that influence personal exposures to ambient fine-particulate matter (PM_2.5). We describe and compare different ambient PM_2.5 exposure estimation...

Nitrous oxide fluxes and nitrogen cycling along a pasturechronosequence in Central Amazonia, Brazil

Treesearch

B. Wick; E. Veldkamp; W. Z. de Mello; M. Keller; P. Crill

2005-01-01

We studied nitrous oxide (N2O) fluxes and soil nitrogen (N) cycling following forest conversion to pasture in the central Amazon near Santarém, Pará, Brazil. Two undisturbed forest sites and 27 pasture sites of 0.5 to 60 years were sampled once each during wet and dry seasons. In addition to soil-atmosphere fluxes of N...

Spatial and Temporal Genetic Analyses Show High Gene Flow Among European Corn Borer (Lepidoptera: Crambidae) Populations Across the Central U.S. Corn Belt

USDA-ARS?s Scientific Manuscript database

European corn borer, Ostrinia nubilalis, were sampled at 13 sites along two perpendicular 720 km transects intersecting in central Iowa, and two generations later at 4 of the same sites separated by 150-km in the cardinal directions. More than 50 moths from each sample location and time were genoty...

Site-specific effects of the nonsteroidal anti-inflammatory drug lysine clonixinate on rat brain opioid receptors.

PubMed

Ortí, E; Coirini, H; Pico, J C

1999-04-01

In addition to effects in the periphery through inhibition of prostaglandin synthesis, several lines of evidence suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) act in the central nervous system. The possibility that the central action of NSAIDs involves regulation of opioid receptors was investigated by quantitative autoradiography of mu, delta, and kappa sites in rat brain slices. Increased (p < 0.05) labeling of mu receptors was observed in thalamic nuclei, gyrus dentate, and layers of the parietal cortex of rats treated for 10 days with lysine clonixinate. Labeling of delta receptors was lower in the lateral septum, and kappa sites decreased in thalamic nuclei. These effects were not mediated through direct interaction with opioid-binding sites, since receptor-binding assays using rat brain membranes confirmed that clonixinate up to 1 x 10(-4) mol/l does not inhibit mu, delta, and kappa receptor specific binding. Central effects of NSAIDs might, therefore, involve interaction with the opioid receptor system through indirect mechanisms.

Molting site fidelity accounts for colony elimination of the Formosan subterranean termites (Isoptera: Rhinotermitidae) by chitin synthesis inhibitor baits.

PubMed

Kakkar, G; Osbrink, W; Su, N-Y

2018-01-19

Site fidelity by molting termites in Formosan subterranean termite, Coptotermes formosanus Shiraki colonies is a new addition to our understanding of lower termites' behavior and biology. Our previous studies indicated that workers moved to the central nest to molt in the presence of eggs and reproductives. The current study showed that noviflumuron-affected workers also return to the central nest and died in the vicinity of reproductives and eggs. The aversion to the dead and decaying workers caused reproductives and brood to leave the original central nest site in a colony and refuge at newer sites every few days in response to newly dead workers near them. Because mortality was an event observed only in workers undergoing molting under the effect of noviflumuron- a CSI, the death of molting individuals was observed only around reproductives and brood. This study reveals a previously undiscovered behavior of molting termites and the mechanics behind a successful arsenal; noviflumuron baits used against subterranean termites.

TBT and its metabolites in sediments: Survey at a German coastal site and the central Baltic Sea.

PubMed

Abraham, Marion; Westphal, Lina; Hand, Ines; Lerz, Astrid; Jeschek, Jenny; Bunke, Dennis; Leipe, Thomas; Schulz-Bull, Detlef

2017-08-15

Since the 1950s the organotin compound tributyltin (TBT) was intensively used in antifouling paints for marine vessels and it became of concern for the marine environment. Herein, we report on a study from 2015 on TBT and its metabolites monobutyltin (MBT) and dibutyltin (DBT) in sediments from the central Baltic Sea and a Baltic Sea coastal site with strong harbor activities (Warnemünde). Sublayers from a sediment core from the Arkona Basin were analyzed to investigate the long term organotin pressure for the Baltic Sea. For the central Baltic Sea total organotin (MBT+DBT+TBT) ranged from 100 to 500ng/g TOC with distinct areas of high organotin content probably due to historical inputs. For the coastal site total organotin ranged from 10,000 to 60,000ng/g TOC. MBT and DBT were the predominant organotin species detected. Overall, the data obtained indicate the progress of TBT degradation at the investigated sites. Copyright © 2017 Elsevier Ltd. All rights reserved.

FoxP2 brainstem neurons project to sodium appetite regulatory sites.

PubMed

Shin, Jung-Won; Geerling, Joel C; Stein, Matthew K; Miller, Rebecca L; Loewy, Arthur D

2011-09-01

The transcription factor Forkhead box protein 2 (FoxP2) is expressed in two cell groups of the brainstem that have been implicated in sodium appetite regulation: the pre-locus coeruleus (pre-LC) and parabrachial nucleus--external lateral-inner subdivision (PBel-inner). Because the connections of these two groups are unknown, neuroanatomical tracing methods were used to define their central projections. The pre-LC outputs were first analyzed using an anterograde axonal tracer--Phaseolus vulgaris leucoagglutinin (PHAL) to construct a brain map. Next, we examined whether the FoxP2 immunoreactive (FoxP2+) neurons of the pre-LC contribute to these projections using a retrograde neuronal tracer--cholera toxin β-subunit (CTb). CTb was injected into selected brain regions identified in the anterograde tracing study. One week later the rats were killed, and brainstem sections were processed by a double immunohistochemical procedure to determine whether the FoxP2+ neurons in the pre-LC and/or PBel-inner contained CTb. FoxP2+ pre-LC neurons project to: (1) ventral pallidum; (2) substantia innominata and bed nucleus of the stria terminalis; (3) paraventricular, central medial, parafascicular, and subparafascicular parvicellular thalamic nuclei; (4) paraventricular (PVH), lateral, perifornical, dorsomedial (DMH), and parasubthalamic hypothalamic nuclei; and (5) ventral tegmental area (VTA), periaqueductal gray matter (PAG), dorsal and central linear raphe nuclei. FoxP2+ PBel-inner neurons project to the PVH and DMH, with weaker connections to the LHA, VTA, and PAG. Both the pre-LC and PBel-inner project to central sites implicated in sodium appetite, and related issues, including foraging behavior, hedonic responses to salt intake, sodium balance, and cardiovascular regulation, are discussed. Copyright © 2011 Elsevier B.V. All rights reserved.

Group living enhances individual resources discrimination: the use of public information by cockroaches to assess shelter quality.

PubMed

Canonge, Stéphane; Deneubourg, Jean-Louis; Sempo, Grégory

2011-01-01

In group-living organisms, consensual decision of site selection results from the interplay between individual responses to site characteristics and to group-members. Individuals independently gather personal information by exploring their environment. Through social interaction, the presence of others provides public information that could be used by individuals and modulates the individual probability of joining/leaving a site. The way that individual's information processing and the network of interactions influence the dynamics of public information (depending on population size) that in turn affect discrimination in site quality is a central question. Using binary choice between sheltering sites of different quality, we demonstrate that cockroaches in group dramatically outperform the problem-solving ability of single individual. Such use of public information allows animals to discriminate between alternatives whereas isolated individuals are ineffective (i.e. the personal discrimination efficiency is weak). Our theoretical results, obtained from a mathematical model based on behavioral rules derived from experiments, highlight that the collective discrimination emerges from competing amplification processes relying on the modulation of the individual sheltering time without shelters comparison and communication modulation. Finally, we well demonstrated here the adaptive value of such decision algorithm. Without any behavioral change, the system is able to shift to a more effective strategy when alternatives are present: the modification of the spatio-temporal distributions of individuals leading to the collective selection of the best resource. This collective discrimination implying such parsimonious and widespread mechanism must be shared by many group living-species.

Abortion law reforms in Colombia and Nicaragua: issue networks and opportunity contexts.

PubMed

Reuterswärd, Camilla; Zetterberg, Pär; Thapar-Björkert, Suruchi; Molyneux, Maxine

2011-01-01

This article analyses two instances of abortion law reform in Latin America. In 2006, after a decades-long impasse, the highly controversial issue of abortion came to dominate the political agenda when Colombia liberalized its abortion law and Nicaragua adopted a total ban on abortion. The article analyses the central actors in the reform processes, their strategies and the opportunity contexts. Drawing on Htun's (2003) framework, it examines why these processes concluded with opposing legislative outcomes. The authors argue for the need to understand the state as a non-unitary site of politics and policy, and for judicial processes to be seen as a key variable in facilitating gender policy reforms in Latin America. In addition, they argue that ‘windows of opportunity’ such as the timing of elections can be critically important in legislative change processes.

Control Points To Reduce Movement of Central Nervous System Tissue during Beef Slaughter.

PubMed

Aalhus, J L; Thacker, R D; Larsen, I L; Roberts, J C; Price, M A; Juárez, M

2017-02-01

Consumption of central nervous system tissue (CNST) from cattle with bovine spongiform encephalopathy (BSE) is thought to cause the human neurological disease, variant Creutzfeldt-Jacob disease. To identify points of cross-contamination of beef carcasses with CNST, 55 young beef cattle were slaughtered and processed through a federally inspected multispecies abattoir. The objectives of this study were to evaluate CNST spread following the placement of a plug in the penetration site of the skull after captive bolt stunning, to evaluate cross-contamination of carcasses before and after splitting, to compare the effects of hot water pasteurization (84°C for 10 s) versus cold water wash (10°C for 30 s) for reducing CNST on the carcass, and to examine other possible sources of cross-contamination in the abattoir. Results indicated that the use of a plastic plug reduced CNST contamination near the bolt penetration site. This study also confirmed that carcass splitting resulted in an increase in CNST contamination at various areas of the carcass. Hot water pasteurization appeared to be an effective means of removing CNST contamination from carcasses in most of the areas sampled.

Dental calculus reveals unique insights into food items, cooking and plant processing in prehistoric central Sudan.

PubMed

Buckley, Stephen; Usai, Donatella; Jakob, Tina; Radini, Anita; Hardy, Karen

2014-01-01

Accessing information on plant consumption before the adoption of agriculture is challenging. However, there is growing evidence for use of locally available wild plants from an increasing number of pre-agrarian sites, suggesting broad ecological knowledge. The extraction of chemical compounds and microfossils from dental calculus removed from ancient teeth offers an entirely new perspective on dietary reconstruction, as it provides empirical results on material that is already in the mouth. Here we present a suite of results from the multi-period Central Sudanese site of Al Khiday. We demonstrate the ingestion in both pre-agricultural and agricultural periods of Cyperus rotundus tubers. This plant is a good source of carbohydrates and has many useful medicinal and aromatic qualities, though today it is considered to be the world's most costly weed. Its ability to inhibit Streptococcus mutans may have contributed to the unexpectedly low level of caries found in the agricultural population. Other evidence extracted from the dental calculus includes smoke inhalation, dry (roasting) and wet (heating in water) cooking, a second plant possibly from the Triticaceae tribe and plant fibres suggestive of raw material preparation through chewing.

Dental Calculus Reveals Unique Insights into Food Items, Cooking and Plant Processing in Prehistoric Central Sudan

PubMed Central

Buckley, Stephen; Usai, Donatella; Jakob, Tina; Radini, Anita; Hardy, Karen

2014-01-01

Accessing information on plant consumption before the adoption of agriculture is challenging. However, there is growing evidence for use of locally available wild plants from an increasing number of pre-agrarian sites, suggesting broad ecological knowledge. The extraction of chemical compounds and microfossils from dental calculus removed from ancient teeth offers an entirely new perspective on dietary reconstruction, as it provides empirical results on material that is already in the mouth. Here we present a suite of results from the multi-period Central Sudanese site of Al Khiday. We demonstrate the ingestion in both pre-agricultural and agricultural periods of Cyperus rotundus tubers. This plant is a good source of carbohydrates and has many useful medicinal and aromatic qualities, though today it is considered to be the world's most costly weed. Its ability to inhibit Streptococcus mutans may have contributed to the unexpectedly low level of caries found in the agricultural population. Other evidence extracted from the dental calculus includes smoke inhalation, dry (roasting) and wet (heating in water) cooking, a second plant possibly from the Triticaceae tribe and plant fibres suggestive of raw material preparation through chewing. PMID:25028938

The influence of soil-site factors on sugar maple (Acer saccharum Marsh.) growth response to climatic change in central Ontario

NASA Astrophysics Data System (ADS)

Schutten, K.; Gedalof, Z.

2010-12-01

Over the past several decades, concerns about climatic change and its potential impacts on Canada’s various geographical regions and associated ecological processes have grown steadily, especially among land and resource managers. As these risks transition into tangible outcomes in the field, it will be important for resource managers to understand historical climatic variability and natural ecological trends in order to effectively respond to a changing climate. Sugar maple (Acer saccharum Marsh.) is considered a stable endpoint for mature forests in the northern hardwood community of central Ontario, and it tends to be the dominant species, in a beech-ironwood-yellow birch matrix. In North America, this species is used for both hardwood lumber and for maple sugar (syrup) products; where it dominates, large recreational opportunities also exist. There are many biotic and abiotic factors that play a large role in the growth and productivity of sugar maple stands, such as soil pH, moisture regime, and site slope and aspect. This research undertaking aims to add to the body of literature addressing the following question: how do site factors influence the sensitivity of sugar maple growth to climatic change? The overall objective of the research is to evaluate how biotic and abiotic factors influence the sensitivity of sugar maple annual radial growth to climatic variability. This research will focus on sugar maple growth and productivity in Algonquin Provincial Park, and the impact that climatic variability has had in the past on these stands based on site-specific characteristics. In order to complete this goal, 20 sites were identified in Algonquin Provincial Park based on variability of known soil and site properties. These sites were visited in order to collect biotic and abiotic site data, and to measure annual radial growth increment of trees. Using regional climate records and standard dendrochronological methods, the collected increment growth data will be used to build site-specific chronologies in order to determine the differences in tree growth response to climatic variability due to differences in soil and site quality. Preliminary results suggest that variability in site-specific abiotic and biotic conditions may strongly influence individual stand growth responses to climatic variability.

Comparisons of traffic-related ultrafine particle number concentrations measured in two urban areas by central, residential, and mobile monitoring

NASA Astrophysics Data System (ADS)

Simon, Matthew C.; Hudda, Neelakshi; Naumova, Elena N.; Levy, Jonathan I.; Brugge, Doug; Durant, John L.

2017-11-01

Traffic-related ultrafine particles (UFP; <100 nm diameter) are ubiquitous in urban air. While studies have shown that UFP are toxic, epidemiological evidence of health effects, which is needed to inform risk assessment at the population scale, is limited due to challenges of accurately estimating UFP exposures. Epidemiologic studies often use empirical models to estimate UFP exposures; however, the monitoring strategies upon which the models are based have varied between studies. Our study compares particle number concentrations (PNC; a proxy for UFP) measured by three different monitoring approaches (central-site, short-term residential-site, and mobile on-road monitoring) in two study areas in metropolitan Boston (MA, USA). Our objectives were to quantify ambient PNC differences between the three monitoring platforms, compare the temporal patterns and the spatial heterogeneity of PNC between the monitoring platforms, and identify factors that affect correlations across the platforms. We collected >12,000 h of measurements at the central sites, 1000 h of measurements at each of 20 residential sites in the two study areas, and >120 h of mobile measurements over the course of ∼1 year in each study area. Our results show differences between the monitoring strategies: mean 1 min PNC on-roads were higher (64,000 and 32,000 particles/cm3 in Boston and Chelsea, respectively) compared to central-site measurements (23,000 and 19,000 particles/cm3) and both were higher than at residences (14,000 and 15,000 particles/cm3). Temporal correlations and spatial heterogeneity also differed between the platforms. Temporal correlations were generally highest between central and residential sites, and lowest between central-site and on-road measurements. We observed the greatest spatial heterogeneity across monitoring platforms during the morning rush hours (06:00-09:00) and the lowest during the overnight hours (18:00-06:00). Longer averaging times (days and hours vs. minutes) increased temporal correlations (Pearson correlations were 0.69 and 0.60 vs. 0.39 in Boston; 0.71 and 0.61 vs. 0.45 in Chelsea) and reduced spatial heterogeneity (coefficients of divergence were 0.24 and 0.29 vs. 0.33 in Boston; 0.20 and 0.27 vs. 0.31 in Chelsea). Our results suggest that combining stationary and mobile monitoring may lead to improved characterization of UFP in urban areas.

A chronological framework connecting the early Upper Palaeolithic across the Central Asian piedmont.

PubMed

Fitzsimmons, Kathryn E; Iovita, Radu; Sprafke, Tobias; Glantz, Michelle; Talamo, Sahra; Horton, Katharine; Beeton, Tyler; Alipova, Saya; Bekseitov, Galymzhan; Ospanov, Yerbolat; Deom, Jean-Marc; Sala, Renato; Taimagambetov, Zhaken

2017-12-01

Central Asia has delivered significant paleoanthropological discoveries in the past few years. New genetic data indicate that at least two archaic human species met and interbred with anatomically modern humans as they arrived into northern Central Asia. However, data are limited: known archaeological sites with lithic assemblages generally lack human fossils, and consequently identifying the archaeological signatures of different human groups, and the timing of their occupation, remains elusive. Reliable chronologic data from sites in the region, crucial to our understanding of the timing and duration of interactions between different human species, are rare. Here we present chronologies for two open air Middle to Upper Palaeolithic (UP) sequences from the Tien Shan piedmont in southeast Kazakhstan, Maibulak and Valikhanova, which bridge southern and northern Central Asia. The chronologies, based on both quartz optically stimulated luminescence (OSL) and polymineral post-infrared infrared luminescence (pIR-IRSL) protocols, demonstrate that technological developments at the two sites differ substantially over the ∼47-19 ka time span. Some of the innovations typically associated with the earliest UP in the Altai or other parts of northeast Asia are also present in the Tien Shan piedmont. We caution against making assumptions about the directionality of spread of these technologies until a larger, better defined database of transitional sites in the region is available. Connections between the timing of occupation of regions, living area setting and paleoenvironmental conditions, while providing hypotheses worth exploring, remain inconclusive. We cautiously suggest a trend towards increasing occupation of open air sites across the Central Asian piedmont after ∼40 ka, corresponding to more humid climatic conditions which nevertheless included pulses of dust deposition. Human occupation persisted into the Last Glacial Maximum, despite cooler, and possibly drier, conditions. Our results thus provide additional data to substantiate arguments for occupation of Central Asia. Copyright © 2017 Elsevier Ltd. All rights reserved.

U-PLANT GEOGRAPHIC ZONE CLEANUP PROTOTYPE

DOE Office of Scientific and Technical Information (OSTI.GOV)

ROMINE, L.D.

2006-02-01

The U Plant geographic zone (UPZ) occupies 0.83 square kilometers on the Hanford Site Central Plateau (200 Area). It encompasses the U Plant canyon (221-U Facility), ancillary facilities that supported the canyon, soil waste sites, and underground pipelines. The UPZ cleanup initiative coordinates the cleanup of the major facilities, ancillary facilities, waste sites, and contaminated pipelines (collectively identified as ''cleanup items'') within the geographic zone. The UPZ was selected as a geographic cleanup zone prototype for resolving regulatory, technical, and stakeholder issues and demonstrating cleanup methods for several reasons: most of the area is inactive, sufficient characterization information is availablemore » to support decisions, cleanup of the high-risk waste sites will help protect the groundwater, and the zone contains a representative cross-section of the types of cleanup actions that will be required in other geographic zones. The UPZ cleanup demonstrates the first of 22 integrated zone cleanup actions on the Hanford Site Central Plateau to address threats to groundwater, the environment, and human health. The UPZ contains more than 100 individual cleanup items. Cleanup actions in the zone will be undertaken using multiple regulatory processes and decision documents. Cleanup actions will include building demolition, waste site and pipeline excavation, and the construction of multiple, large engineered barriers. In some cases, different cleanup actions may be taken at item locations that are immediately adjacent to each other. The cleanup planning and field activities for each cleanup item must be undertaken in a coordinated and cohesive manner to ensure effective execution of the UPZ cleanup initiative. The UPZ zone cleanup implementation plan (ZCIP) was developed to address the need for a fundamental integration tool for UPZ cleanup. As UPZ cleanup planning and implementation moves forward, the ZCIP is intended to be a living document that will provide a focal point for integrating UPZ actions, including field cleanup activities, waste staging and handling, and post-cleanup monitoring and institutional controls.« less

Atmospheric deposition of trace elements at urban and forest sites in central Poland - Insight into seasonal variability and sources

NASA Astrophysics Data System (ADS)

Siudek, Patrycja; Frankowski, Marcin

2017-12-01

This paper includes the results of chemical composition of bulk deposition samples collected simultaneously at urban (Poznań city) and forest (Jeziory) sites in central Poland, between April 2013 and October 2014. Rainwater samples were analyzed for trace elements (As, Zn, Ni, Pb, Cu, Cr, Cd) and physicochemical parameters. Overall, three metals, i.e. Zn, Pb and Cu were the most abundant anthropogenic constituents of rainwater samples from both locations. In Poznań city, the rainwater concentrations of trace elements did not differ significantly between spring and summer. However, they were elevated and more variable during the cold season (fall and winter), suggesting strong contribution from local high-temperature processes related to coal combustion (commercial and residential sector). In contrast to the urban site, relatively low variability in concentrations was found for Cu, Ni, Zn at the forest site, where direct impact of emission from vehicle traffic and coal-fired combustion (power plants) was much lower. The bulk deposition fluxes of Ni, As, Pb and Zn at this site exhibited a clear trend, with higher values during the cold season (fall and winter) than in spring and summer. At the urban site, the sums of total bulk deposition fluxes of Zn, Cu, Pb, Ni, As, Cr, Cd were as follows: 8460.4, 4209.2, 2247.4, 1882.1, 606.6, 281.6 and 31.4 μg m- 2. In addition, during the winter season, a significantly higher deposition fluxes of Cu and Zn were observed for rain (on average 103.8 and 129.4 μg m- 2, respectively) as compared to snow (19.7 μg Cu m- 2 and 54.1 μg Zn m- 2). This suggests that different deposition pattern of trace elements for rain, mixed and snow was probably the effect of several factors: precipitation type, changes in emission and favorable meteorological situation during rain events.

Permeability and microstructural changes due to weathering of pyroclastic rocks in Cappadocia, central Turkey

NASA Astrophysics Data System (ADS)

Sato, M.; Takahashi, M.; Anma, R.; Shiomi, K.

2014-12-01

Studies of permeability changes of rocks during weathering are important to understand the processes of geomorphological development and how they are influenced by cyclic climatic conditions. Especially volcanic tuffs and pyroclastic flow deposits are easily affected by water absorption and freezing-thawing cycle (Erguler. 2009, Çelik and Ergül 2014). Peculiar erosional landscapes of Cappadocia, central Turkey, with numerous underground cities and carved churches, that made this area a world heritage site, are consists of volcanic tuffs and pyroclastic flow deposits. Understanding permeability changes of such rocks under different conditions are thus important not only to understand fundamental processes of weathering, but also to protect the landscapes of the world heritage sites and archaeological remains. In this study, we aim to evaluate internal void structures and bulk permeability of intact and weathered pyroclastic rocks from Cappadocia using X-ray CT, mercury intrusion porosimetry data and permeability measurement method of flow pump test. Samples of pyroclastic deposits that comprise the landscapes of Rose Valley and Ihlara Valley, were collected from the corresponding strata outside of the preservation areas. Porosity and pore-size distribution for the same samples measured by mercury intrusion porosimetry, indicate that the intact samples have lower porosity than weathered samples and pore sizes were dominantly 1-10μm in calculated radii, whereas weathered samples have more micropores (smaller than 1 μm). X-ray CT images were acquired to observe internal structure of samples. Micro-fractures, probably caused by repeated expansion and contraction due to temperature changes, were observed around clast grains. The higher micropore ratio in weathered samples could be attributed to the development of the micro-farctures. We will discuss fundamental processes of weathering and geomorphological development models using these data.

The effect of native-language experience on the sensory-obligatory components, the P1–N1–P2 and the T-complex

PubMed Central

Wagner, Monica; Shafer, Valerie L.; Martin, Brett; Steinschneider, Mitchell

2013-01-01

The influence of native-language experience on sensory-obligatory auditory-evoked potentials (AEPs) was investigated in native-English and native-Polish listeners. AEPs were recorded to the first word in nonsense word pairs, while participants performed a syllable identification task to the second word in the pairs. Nonsense words contained phoneme sequence onsets (i.e., /pt/, /pət/, /st/ and /sət/) that occur in the Polish and English languages, with the exception that /pt/ at syllable onset is an illegal phonotactic form in English. P1–N1–P2 waveforms from fronto-central electrode sites were comparable in English and Polish listeners, even though, these same English participants were unable to distinguish the nonsense words having /pt/ and /pət/ onsets. The P1–N1–P2 complex indexed the temporal characteristics of the word stimuli in the same manner for both language groups. Taken together, these findings suggest that the fronto-central P1–N1–P2 complex reflects acoustic feature processing of speech and is not significantly influenced by exposure to the phoneme sequences of the native-language. In contrast, the T-complex from bilateral posterior temporal sites was found to index phonological as well as acoustic feature processing to the nonsense word stimuli. An enhanced negativity for the /pt/ cluster relative to its contrast sequence (i.e., /pət/) occurred only for the Polish listeners, suggesting that neural networks within non-primary auditory cortex may be involved in early cortical phonological processing. PMID:23643857

Chilled water study EEAP program for Walter Reed Army Medical Center: Book 2. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-01

The Energy Engineering Analysis Program (EEAP) Study for Walter Reed Army Medical Center (WRAMC) was to provide a thorough examination of the central chilled water plants on site. WRAMC is comprised of seventy-one (71) buildings located on a 113-acre site in Washington, D.C. There are two (2) central chilled water plants (Buildings 48 and 49) each with a primary chilled water distribution system. In addition to the two (2) central plants, three (3) buildings utilize their own independent chillers. Two (2) of the independent chillers (Buildings 7 and T-2), one of which is inoperative (T-2), are smaller air-cooled units, whilemore » the third (Building 54) has a 1,900-ton chilled water plant comprised of three (3) centrifugal chillers. Of the two (2) central chilled water plants, Building 48 houses six (6) chillers totalling 7,080 tons of cooling and Building 49 houses one (1) chiller with 660 tons of cooling. The total chiller cooling capacity available on site is 9,840 tons. The chilled water systems were reviewed for alternative ways of conserving energy on site and reducing the peak-cooling load. Distribution systems were reviewed to determine which buildings were served by each of the chilled water plants and to determine chilled water usage on site. Evaluations were made of building exterior and interior composition in order to estimate cooling loads. Interviews with site personnel helped Entech better understand the chilled water plants, the distribution systems, and how each system was utilized.« less

An application of bioassessment metrics and multivariate techniques to evaluate central Nebraska streams

USGS Publications Warehouse

Frenzel, S.A.

1996-01-01

Ninety-one stream sites in central Nebraska were classified into four clusters on the basis of a cluster analysis (TWINSPAN) of macroinvertebrate data. Rapid bioassessment protocol scores for macroinvertebrate species were significantly different among sites grouped by teh first division into two clusters. This division may have distinguished sites on the basis of water-quality imparement. Individual metrics that differed between clusters of sites were the Hilsenhoff Biotic Index, the number of Ephemeroptera, Plecoptera, and Trichoptera (EPT) taxa, and the ratio of individuals in EPT to Chironomidae taxa. Canonical correspondence analysis of 57 of 91 sites showed that stream width, site altitude, latitude, soil permeability, water temperature, and mean annual precipitation were the most important environmental variables describing variance in the species-environment relation. Stream width and soil permeability reflected streamflow characteristics of a site, whereas site altitude and latitude were factors related to general climatic conditions. Mean annual precipitation related to both streamflow and climatic conditions.

Summer behavior of adult radio-equipped woodcock in central Maine

USGS Publications Warehouse

Owen, R.B.; Morgan, J.W.

1975-01-01

The behavior of 26 adult American woodcock (Philohela minor) was studied in central Maine during the summers of 1971-73 using radiotelemetry. Adults used diurnal covers and nocturnal sites that were similar to those previously recorded for immature woodcock. The adults, however, were more active during the daylight hours and moved to nocturnal sites later in the evening. Adult woodcock seemed to be less susceptible than immatures to capture by banding crews at night, because adults walked more often between diurnal and nocturnal sites and remained close to the brushy edges at night. Adult birds occupied a smaller composite summer range than the immatures, did not move as far from their capture sites dunng the observation penods, and traveled shorter distances between diurnal and nocturnal sites.

Uncoupling neurogenic gene networks in the Drosophila embryo.

PubMed

Rogers, William A; Goyal, Yogesh; Yamaya, Kei; Shvartsman, Stanislav Y; Levine, Michael S

2017-04-01

The EGF signaling pathway specifies neuronal identities in the Drosophila embryo by regulating developmental patterning genes such as intermediate neuroblasts defective ( ind ). EGFR is activated in the ventral midline and neurogenic ectoderm by the Spitz ligand, which is processed by the Rhomboid protease. CRISPR/Cas9 was used to delete defined rhomboid enhancers mediating expression at each site of Spitz processing. Surprisingly, the neurogenic ectoderm, not the ventral midline, was found to be the dominant source of EGF patterning activity. We suggest that Drosophila is undergoing an evolutionary transition in central nervous system (CNS)-organizing activity from the ventral midline to the neurogenic ectoderm. © 2017 Rogers et al.; Published by Cold Spring Harbor Laboratory Press.

Analysis of recreational land using Skylab data. [Gratiot-Saginaw State Game Area, Michigan

NASA Technical Reports Server (NTRS)

Sattinger, I. J. (Principal Investigator); Sadowski, F. G.; Roller, N. E. G.

1976-01-01

The author has identified the following significant results. S192 data collected on 5 August 1973 were processed by computer to produce a classification map of a part of the Gratiot-Saginaw State Game Area in south central Michigan. A 10-category map was prepared of an area consisting of diverse terrain types, including forests, wetlands, brush, and herbaceous vegetation. An accuracy check indicated that 54% of the pixels were correctly recognized. When these ten scene classes were consolidated to a 5-category map, the accuracy increased to 72%. S190 A, S190 B, and S192 data can be used for regional surveys of existing and potential recreation sites, for delineation of open space, and for preliminary evaluation of geographically extensive sites.

Testing the Simple Biosphere model (SiB) using point micrometeorological and biophysical data

NASA Technical Reports Server (NTRS)

Sellers, P. J.; Dorman, J. L.

1987-01-01

The suitability of the Simple Biosphere (SiB) model of Sellers et al. (1986) for calculation of the surface fluxes for use within general circulation models is assessed. The structure of the SiB model is described, and its performance is evaluated in terms of its ability to realistically and accurately simulate biophysical processes over a number of test sites, including Ruthe (Germany), South Carolina (U.S.), and Central Wales (UK), for which point biophysical and micrometeorological data were available. The model produced simulations of the energy balances of barley, wheat, maize, and Norway Spruce sites over periods ranging from 1 to 40 days. Generally, it was found that the model reproduced time series of latent, sensible, and ground-heat fluxes and surface radiative temperature comparable with the available data.

Splicing fidelity: DEAD/H-box ATPases as molecular clocks.

PubMed

Koodathingal, Prakash; Staley, Jonathan P

2013-07-01

The spliceosome discriminates against suboptimal substrates, both during assembly and catalysis, thereby enhancing specificity during pre-mRNA splicing. Central to such fidelity mechanisms are a conserved subset of the DEAD- and DEAH-box ATPases, which belong to a superfamily of proteins that mediate RNP rearrangements in almost all RNA-dependent processes in the cell. Through an investigation of the mechanisms contributing to the specificity of 5' splice site cleavage, two related reports, one from our lab and the other from the Cheng lab, have provided insights into fidelity mechanisms utilized by the spliceosome. In our work, we found evidence for a kinetic proofreading mechanism in splicing in which the DEAH-box ATPase Prp16 discriminates against substrates undergoing slow 5' splice site cleavage. Additionally, our study revealed that discriminated substrates are discarded through a general spliceosome disassembly pathway, mediated by another DEAH-box ATPase Prp43. In their work, Tseng et al. described the underlying molecular events through which Prp16 discriminates against a splicing substrate during 5' splice site cleavage. Here, we present a synthesis of these two studies and, additionally, provide the first biochemical evidence for discrimination of a suboptimal splicing substrate just prior to 5' splice site cleavage. Together, these findings support a general mechanism for a ubiquitous superfamily of ATPases in enhancing specificity during RNA-dependent processes in the cell.

Internet-based transfer of cardiac ultrasound images

NASA Technical Reports Server (NTRS)

Firstenberg, M. S.; Greenberg, N. L.; Garcia, M. J.; Morehead, A. J.; Cardon, L. A.; Klein, A. L.; Thomas, J. D.

2000-01-01

A drawback to large-scale multicentre studies is the time required for the centralized evaluation of diagnostic images. We evaluated the feasibility of digital transfer of echocardiographic images to a central laboratory for rapid and accurate interpretation. Ten patients undergoing trans-oesophageal echocardiographic scanning at three sites had representative single images and multiframe loops stored digitally. The images were analysed in the ordinary way. All images were then transferred via the Internet to a central laboratory and reanalysed by a different observer. The file sizes were 1.5-72 MByte and the transfer rates achieved were 0.6-4.8 Mbit/min. Quantitative measurements were similar between most on-site and central laboratory measurements (all P > 0.25), although measurements differed for left atrial width and pulmonary venous systolic velocities (both P < 0.05). Digital transfer of echocardiographic images and data to a central laboratory may be useful for multicentre trials.

Response of middle-taiga permafrost landscapes of Central Siberia to global warming in the late 20th and early 21st centuries

NASA Astrophysics Data System (ADS)

Medvedkov, Alexey A.

2016-11-01

In this paper, regional features of a climatogenic response of the middle-taiga permafrost landscapes of Central Siberia, as well as corresponding transformations of the exodynamic processes, are considered. Lithological-geomorphologic and landscape- geocryological data are analyzed with large amounts of actual data and results of monitoring surveys. Specific features of an ecotone localization of middle-taiga permafrost landscapes and their typical physiognomic characteristics are described. A comprehensive investigation of representative key sites makes it possible to discover the response of different types of permafrost landscapes to regional climate warming. A rapid increase in the active layer depth, slower creep, transformations of the moving kurums, intensive solifluction, and a local replacement of solifluction by landslides-earthflows are revealed within ecotone landscapes of the cryolithozone.

Contributions of Neutrophils to Resolution of Mucosal Inflammation

PubMed Central

Colgan, Sean P.; Ehrentraut, Stefan F.; Glover, Louise E.; Kominsky, Douglas J.; Campbell, Eric L.

2014-01-01

Neutrophil (PMN) recruitment from the blood stream into surrounding tissues involves a regulated series of events central to acute responses in host defense. Accumulation of PMN within mucosal tissues have historically been considered pathognomonic features of both acute and chronic inflammatory conditions. Historically PMNs have been deemed necessary but detrimental when recruited, given the potential for tissue damage that results from a variety of mechanisms. Recent work, however, has altered our preconcieved notions of PMN contributions to inflammatory processes. In particular, significant evidence implicates a central role for the PMN in triggering inflammatory resolution. Such mechanisms involve both metabolic and biochemical crosstalk pathways during the intimate interactions of PMN with other cell types at inflammatory sites. Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa. PMID:22968707

Site index curves for black, white, scarlet, and chestnut oaks in the Central States.

Treesearch

Willard H. Carmean

1971-01-01

Stem analyses showed polymorphic patterns of height growth for each species and for different levels of site quality. New site index curves are presented that show better height growth in later years than predicted by older harmonized site index curves.

Using atmospheric chemistry and storm tracks to explain nitrate stable isotope variations in precipitation at a site in central Pennsylvania, USA

USDA-ARS?s Scientific Manuscript database

Stable isotopes of NO3- (delta15N-NO3- and delta18O-NO3-) were monitored in precipitation at a central Pennsylvania site during six storm events in 2005 to determine whether information on atmospheric oxidants (e.g. O3, NO2, and NOx), and storm-tracks were capable of explaining observed seasonal and...

Fourth-Year Effects of Thinning on Growth and Epicormic Branching in a Red Oak-Sweetgum Stand on a Minor Streambottom Site in West-Central Alabama

Treesearch

James S. Meadows; J.C.G. Goelz

2002-01-01

Abstract - Four thinning treatments were applied to a 60-year-old, red oak-sweetgum (Quercus spp.-Liquidambar styraciflua L.) stand on a minor streambottom site in west-central Alabama in late summer 1994: (1) unthinned control; (2) light thinning to 70-75 percent residual stocking; (3) heavy thinning to 50-55...

Third-Year Growth and Bole Quality Responses to Thinning in a Red Oak-Sweetgum Stand on a Minor Streambottom Site in West-Central Alabama

Treesearch

James S. Meadows; J.C.G. Goelz

1999-01-01

Four thinning treatments were applied to a red oak-sweetgum (Quercus spp.-Liquidambar styraciflua L.) stand on a minor streambottom site in west-central Alabama in 1994: (1) unthinned control; (2) light thinning to 70-75 percent residual stocking; (3) heavy thinning to 50-55 percent residual stocking; and (4) B-line thinning to...

Comparing Soil Carbon of Short Rotation Poplar Plantations with Agricultural Crops and Woodlots in North Central United States

Treesearch

Mark D. Coleman; J.G. Isebrands; David N. Tolsted; Virginia R. Tolbert

2004-01-01

We collected soil samples from 27 study sites across North Central United States to compare the soil carbon of short rotation poplar plantations to adjacent agricultural crops and woodlots. Soil organic carbon (SOC) ranged from 20 to more than 160 Mg/ha across the sampled sites. Lowest SOC levels were found in uplands and highest levels in riparian soils. We attributed...

KENNEDY SPACE CENTER, FLA. - Congressman Dave Weldon listens to a presentation about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Congressman Tom Feeney, U.S. Representative Ric Keller, U.S. Senator Bill Nelson, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - Congressman Dave Weldon listens to a presentation about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Congressman Tom Feeney, U.S. Representative Ric Keller, U.S. Senator Bill Nelson, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

KENNEDY SPACE CENTER, FLA. - NASA and government officials are gathered to hear about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Seated at right are Lisa Malone, director of KSC External Affairs, and Joel Wells, with the Government Relations Office. Fourth from right is Jim Jennings, NASA deputy associate administrator for institutions and asset management. Six sites around the U.S. are under consideration for the center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA and government officials are gathered to hear about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Seated at right are Lisa Malone, director of KSC External Affairs, and Joel Wells, with the Government Relations Office. Fourth from right is Jim Jennings, NASA deputy associate administrator for institutions and asset management. Six sites around the U.S. are under consideration for the center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus.

Potential negative impacts of nuclear activities on local economies: Rethinking the issue

DOE Office of Scientific and Technical Information (OSTI.GOV)

Metz, W.C.

1994-10-01

Surveys of public opinion about perceptions of risk associated with the nuclear fuel cycle have shown that the public professes a widespread feeling of dread, a fear of associated stigmas, and a concern about possible catastrophic nuclear accidents. Various interest groups and state governments that oppose congressionally mandated siting of centralized high-level radioactive waste (HLW) storage and disposal facilities are using this negative imagery to create a powerful, emotional obstacle to the siting process. From statistical analyses of images and location preferences, researchers have claimed that possible significant economic losses could potentially accompany the siting of HLW facilities. However, severalmore » paradoxes, or self-contradictory statements, apparently exist between the responses expressed in surveys and the actual economic and demographic behavior evidenced in the marketplace. Federal policymakers need to evaluate whether the request for a change in siting policy is based on subjective fear of a potential negative economic effect or on proven negative effects. Empirically observed behavior does not support predicted negative economic effects based on survey responses. 41 refs.« less

Mesoscale Variation of Mechanisms Contributing to Stability in Rocky Shore Communities

PubMed Central

Valdivia, Nelson; González, Andrés E.; Manzur, Tatiana; Broitman, Bernardo R.

2013-01-01

Environmental fluctuations can generate asynchronous species’ fluctuations and community stability, due to compensatory dynamics of species with different environmental tolerances. We tested this hypothesis in intertidal hard-bottom communities of north-central Chile, where a persistent upwelling centre maintains a mosaic in sea surface temperatures (SST) over 10s of kilometres along the shore. Coastal upwelling implies colder and temporally more stable SST relative to downstream sites. Uni- and multivariate analyses of multiyear timeseries of SST and species abundances showed more asynchronous fluctuations and higher stability in sites characterised by warmer and more variable SST. Nevertheless, these effects were weakened after including data obtained in sites affected by less persistent upwelling centres. Further, dominant species were more stable in sites exposed to high SST variability. The strength of other processes that can influence community stability, chiefly statistical averaging and overyielding, did not vary significantly between SST regimes. Our results provide observational evidence supporting the idea that exogenously driven compensatory dynamics and the stabilising effects of dominant species can determine the stability of ecosystems facing environmental fluctuations. PMID:23326592

Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis.

PubMed

Arvaniti, Kostoula; Lathyris, Dimitrios; Blot, Stijn; Apostolidou-Kiouti, Fani; Koulenti, Despoina; Haidich, Anna-Bettina

2017-04-01

Selection of central venous catheter insertion site in ICU patients could help reduce catheter-related infections. Although subclavian was considered the most appropriate site, its preferential use in ICU patients is not generalized and questioned by contradicted meta-analysis results. In addition, conflicting data exist on alternative site selection whenever subclavian is contraindicated. To compare catheter-related bloodstream infection and colonization risk between the three sites (subclavian, internal jugular, and femoral) in adult ICU patients. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled trials, CINAHL, and ClinicalTrials.gov. Eligible studies were randomized controlled trials and observational ones. Extracted data were analyzed by pairwise and network meta-analysis. Twenty studies were included; 11 were observational, seven were randomized controlled trials for other outcomes, and two were randomized controlled trials for sites. We evaluated 18,554 central venous catheters: 9,331 from observational studies, 5,482 from randomized controlled trials for other outcomes, and 3,741 from randomized controlled trials for sites. Colonization risk was higher for internal jugular (relative risk, 2.25 [95% CI, 1.84-2.75]; I = 0%) and femoral (relative risk, 2.92 [95% CI, 2.11-4.04]; I = 24%), compared with subclavian. Catheter-related bloodstream infection risk was comparable for internal jugular and subclavian, higher for femoral than subclavian (relative risk, 2.44 [95% CI, 1.25-4.75]; I = 61%), and lower for internal jugular than femoral (relative risk, 0.55 [95% CI, 0.34-0.89]; I = 61%). When observational studies that did not control for baseline characteristics were excluded, catheter-related bloodstream infection risk was comparable between the sites. In ICU patients, internal jugular and subclavian may, similarly, decrease catheter-related bloodstream infection risk, when compared with femoral. Subclavian could be suggested as the most appropriate site, whenever colonization risk is considered and not, otherwise, contraindicated. Current evidence on catheter-related bloodstream infection femoral risk, compared with the other sites, is inconclusive.

Conceptual Model of Uranium in the Vadose Zone for Acidic and Alkaline Wastes Discharged at the Hanford Site Central Plateau

DOE Office of Scientific and Technical Information (OSTI.GOV)

Truex, Michael J.; Szecsody, James E.; Qafoku, Nikolla

2014-09-01

Historically, uranium was disposed in waste solutions of varying waste chemistry at the Hanford Site Central Plateau. The character of how uranium was distributed in the vadose zone during disposal, how it has continued to migrate through the vadose zone, and the magnitude of potential impacts on groundwater are strongly influenced by geochemical reactions in the vadose zone. These geochemical reactions can be significantly influenced by the disposed-waste chemistry near the disposal location. This report provides conceptual models and supporting information to describe uranium fate and transport in the vadose zone for both acidic and alkaline wastes discharged at amore » substantial number of waste sites in the Hanford Site Central Plateau. The conceptual models include consideration of how co-disposed acidic or alkaline fluids influence uranium mobility in terms of induced dissolution/precipitation reactions and changes in uranium sorption with a focus on the conditions near the disposal site. This information, when combined with the extensive information describing uranium fate and transport at near background pH conditions, enables focused characterization to support effective fate and transport estimates for uranium in the subsurface.« less

Towards climatological study on the characteristics of aerosols in Central Africa and Mediterranean sites

NASA Astrophysics Data System (ADS)

Benkhalifa, Jamel; Chaabane, Mabrouk

2016-02-01

The atmosphere contains molecules, clouds and aerosols that are sub-millimeter particles having a large variability in size, shape, chemical composition, lifetime and contents. The aerosols concentration depends greatly on the geographical situation, meteorological and environmental conditions, which makes aerosol climatology difficult to assess. Setting up a solar photometer (automatic, autonomous and portable instrument) on a given site allows carrying out the necessary measurements for aerosol characterization. The particle microphysical and optical properties are obtained from photometric measurements. The objective of this study is to analyze the spatial variability of aerosol optical thickness (AOT) in several Mediterranean regions and Central Africa, we considered a set of simultaneous data in the AErosol RObotic NETwork (AERONET) from six sites, two of which are located in Central Africa (Banizoumbou and Zinder Airport) and the rest are Mediterranean sites (Barcelona, Malaga, Lampedusa, and Forth Crete). The results have shown that the physical properties of aerosols are closely linked to the climate nature of the studied site. The optical thickness, single scattering albedo and aerosols size distribution can be due to the aging of the dust aerosol as they are transported over the Mediterranean basin.

Role of proteoglycans in neuro-inflammation and central nervous system fibrosis.

PubMed

Heindryckx, Femke; Li, Jin-Ping

2018-01-31

Fibrosis is defined as the thickening and scarring of connective tissue, usually as a consequence of tissue damage. The central nervous system (CNS) is special in the sense that fibrogenic cells are restricted to vascular and meningeal areas. Inflammation and the disruption of the blood-brain barrier can lead to the infiltration of fibroblasts and trigger fibrotic response. While the initial function of the fibrotic tissue is to restore the blood-brain barrier and to limit the site of injury, it also demolishes the structure of extracellular matrix and impedes the healing process by producing inhibitory molecules and forming a physical and biochemical barrier that prevents axon regeneration. As a major constituent in the extracellular matrix, proteoglycans participate in the neuro-inflammation, modulating the fibrotic process. In this review, we will discuss the pathophysiology of fibrosis during acute injuries of the CNS, as well as during chronic neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and age-related neurodegeneration with focus on the functional roles of proteoglycans. Copyright © 2017 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

A Volcano Monitoring Seismo-Acoustic Network in the CNMI

NASA Astrophysics Data System (ADS)

Howard, J. E.; Crippen, S. E.; Hayward, C.; Quick, J. E.

2011-12-01

In late spring and early summer of 2011, a seismo-acoustic network was installed in the Commonwealth of the Northern Mariana Islands (CNMI) for volcano monitoring. The network consists of a seismo-acoustic array on Saipan, an acoustic array on Sarigan with one seismometer, and a seismic network on Anatahan. On Saipan the array consists of a central site and 3 embedded triangular arrays with apertures of 100 m, 300 m and 1000 m. Four 50-foot porous hoses in a clover-leaf arrangement are used for spatial filtering at each acoustic site. Broadband seismometers were installed at the central site and the 1000 m sites. The Sarigan Array consists of a central acoustic site with 5 surrounding sites evenly spaced at 50 m radius, and one broadband seismic station. Two hoses were used for each site on Sarigan. Four broadband seismic stations were also installed on Anatahan which last erupted in 2005. Data from each array is sent by radio telemetry to the Emergency Management Office on Saipan, where it is routed to the USGS and SMU. Data will be used for volcano monitoring which will allow the CNMI to resume economic activity in the uninhabited northern islands. Initial data streams show high seismic noise levels as expected for an island installation. The Sarigan acoustic sites are also noisy as a result of being more exposed to wind than the Saipan sites. Many small events have already been observed in the infrasound data. This network was installed through the collaborative efforts of CNMI, USGS and SMU.

NASA Shared Services Center breaks ground

NASA Image and Video Library

2006-02-24

NASA officials and elected leaders were on hand for the groundbreaking ceremony of the NASA Shared Services Center Feb. 24, 2006, on the grounds of Stennis Space Center. The NSSC provides agency centralized administrative processing, human resources, procurement and financial services. From left, Louisiana Economic Development Secretary Mike Olivier, Stennis Space Center Director Rick Gilbrech, Computer Sciences Corp. President Michael Laphen, NASA Deputy Administrator Shana Dale, Rep. Gene Taylor, Sen. Trent Lott, Mississippi Gov. Haley Barbour, NASA Administrator Mike Griffin and Shared Services Center Executive Director Arbuthnot use golden shovels to break ground at the site.

NASA Shared Services Center breaks ground

NASA Technical Reports Server (NTRS)

2006-01-01

NASA officials and elected leaders were on hand for the groundbreaking ceremony of the NASA Shared Services Center Feb. 24, 2006, on the grounds of Stennis Space Center. The NSSC provides agency centralized administrative processing, human resources, procurement and financial services. From left, Louisiana Economic Development Secretary Mike Olivier, Stennis Space Center Director Rick Gilbrech, Computer Sciences Corp. President Michael Laphen, NASA Deputy Administrator Shana Dale, Rep. Gene Taylor, Sen. Trent Lott, Mississippi Gov. Haley Barbour, NASA Administrator Mike Griffin and Shared Services Center Executive Director Arbuthnot use golden shovels to break ground at the site.

Siting Patterns of Nuclear Waste Repositories.

ERIC Educational Resources Information Center

Solomon, Barry D.; Shelley, Fred M.

1988-01-01

Provides an inventory of international radioactive waste-management policies and repository siting decisions for North America, Central and South America, Europe, Asia, and Africa. This discussion stresses the important role of demographic, geologic, and political factors in siting decisions. (Author/BSR)

Chilled water study EEAP program for Walter Reed Army Medical Center. Book 1. Final Submission

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-01

The Energy Engineering Analysis Program (EEAP) Study for Walter Reed Army Medical Center (WRAMC) was to provide a thorough examination of the central chilled water plants on site. WRAMC is comprised of seventy-one (71) buildings located on a 113-acre site in Washington, D.C. There are two (2) central chilled water plants (Buildings 48 and 49) each with a primary chilled water distribution system. In addition to the two (2) central plants, three (3) buildings utilize their own independent chillers. Two (2) of the independent chillers (Buildings 7 and T-2), one of which is inoperative (T-2), are smaller air-cooled units, whilemore » the third (Building 54) has a 1,900-ton chilled water plant comprised of three (3) centrifugal chillers. Of the two (2) central chilled water plants, Building 48 houses six (6) chillers totalling 7,080 tons of cooling and Building 49 houses one (1) chiller with 660 tons of cooling. The total chiller cooling capacity available on site is 9,840 tons.« less

A Nubian Complex Site from Central Arabia: Implications for Levallois Taxonomy and Human Dispersals during the Upper Pleistocene

PubMed Central

Crassard, Rémy; Hilbert, Yamandú Hieronymus

2013-01-01

Archaeological survey undertaken in central Saudi Arabia has revealed 29 surface sites attributed to the Arabian Middle Paleolithic based on the presence of Levallois blank production methods. Technological analyses on cores retrieved from Al-Kharj 22 have revealed specific reduction modalities used to produce flakes with predetermined shapes. The identified modalities, which are anchored within the greater Levallois concept of core convexity preparation and exploitation, correspond with those utilized during the Middle Stone Age Nubian Complex of northeast Africa and southern Arabia. The discovery of Nubian technology at the Al-Kharj 22 site represents the first appearance of this blank production method in central Arabia. Here we demonstrate how a rigorous use of technological and taxonomic analysis may enable intra-regional comparisons across the Arabian Peninsula. The discovery of Al-Kharj 22 increases the complexity of the Arabian Middle Paleolithic archaeological record and suggests new dynamics of population movements between the southern and central regions of the Peninsula. This study also addresses the dichotomy within Nubian core typology (Types 1 and 2), which was originally defined for African assemblages. PMID:23894434

Describing Willow Flycatcher habitats: scale perspectives and gender differences

USGS Publications Warehouse

Sedgwick, James A.; Knopf, Fritz L.

1992-01-01

We compared habitat characteristics of nest sites (female-selected sites) and song perch sites (male-selected sites) with those of sites unused by Willow Flycatchers (Empidonax traillii) at three different scales of vegetation measurement: (1) microplot (central willow [Salix spp.] bush and four adjacent bushes); (2) mesoplot (0.07 ha); and, (3) macroplot (flycatcher territory size). Willow Flycatchers exhibited vegetation preferences at all three scales. Nest sites were distinguished by high willow density and low variability in willow patch size and bush height. Song perch sites were characterized by large central shrubs, low central shrub vigor, and high variability in shrub size. Unused sites were characterized by greater distances between willows and willow patches, less willow coverage, and a smaller riparian zone width than either nest or song perch sites. At all scales, nest sites were situated farther from unused sites in multivariate habitat space than were song perch sites, suggesting (1) a correspondence among scales in their ability to describe Willow Flycatcher habitat, and (2) females are more discriminating in habitat selection than males. Microhabitat differences between male-selected (song perch) and female-selected (nest) sites were evident at the two smaller scales; at the finest scale, the segregation in habitat space between male-selected and female-selected sites was greater than that between male-selected and unused sites. Differences between song perch and nest sites were not apparent at the scale of flycatcher territory size, possibly due to inclusion of (1) both nest and song perch sites, (2) defended, but unused habitat, and/or (3) habitat outside of the territory, in larger scale analyses. The differences between nest and song perch sites at the finer scales reflect their different functions (e.g., nest concealment and microclimatic requirements vs. advertising and territorial defense, respectively), and suggest that the exclusive use of either nest or song perch sites in vegetation analyses can result in misleading, or at least incomplete, descriptions of a species' habitat. Habitat interpretations for Willow Flycatchers (and perhaps for many passerines) are a function of the gender-specific behavior of the birds observed and the scale of vegetation measurement.

KSC-04PD-0254

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. KSC Director Jim Kennedy makes a presentation to NASA and other officials about the benefits of locating NASAs new Shared Services Center in the Central Florida Research Park, near Orlando. At the far left is Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

Land Use Change and Hydrologic Processes in High-Elevation Tropical Watersheds of the Northern Andes

NASA Astrophysics Data System (ADS)

Avery, W. A.; Riveros-Iregui, D. A.; Covino, T. P.; Peña, C.

2013-12-01

The humid tropics cover one-fifth of the Earth's land surface and generate the greatest amount of runoff of any biome globally, but remain poorly understood and understudied. Humid tropical regions of the northern and central Andes have experienced greater anthropogenic land-use/land-cover (LULC) change than nearly any other high mountain system in the world. Vast expanses of this region are currently undergoing rapid transformation to farmland for production of potatoes and pasture for cattle grazing. Although the humid tropics have some of the highest runoff ratios, precipitation, and largest river flows in the world, there is a lack of scientific literature that addresses hydrologic processes in these regions and very few field observations are available to inform management strategies to ensure the sustainability of water resources of present and future generations. We seek to improve understanding of hydrologic processes and feedbacks in the humid tropics using existing and new information from two high-elevation watersheds that span a LULC gradient in the Andes Mountains of Colombia. One site is located in the preserved Chingaza Natural National Park in Central Colombia (undisturbed). The second site is located ~60 km to the northwest and has experienced considerable LULC change over the last 40 years. Combined, these watersheds deliver over 80% of the water resources to Bogotá and neighboring communities. These watersheds have similar climatological characteristics (including annual precipitation), but have strong differences in LULC which result in substantial differences in hydrologic response and streamflow dynamics. We present an overview of many of the pressing issues and effects that land degradation and climate change are posing to the long-term sustainability of water resources in the northern Andes. Our overarching goal is to provide process-based knowledge that will be useful to prevent, mitigate, or respond to future water crises along the Andean-Amazon biome and more broadly throughout the understudied humid tropics.

Biology of eating behavior in obesity.

PubMed

Schwartz, Gary J

2004-11-01

Understanding normal and dysfunctional energy regulation and body weight regulation requires neural evaluation of the signals involved in the control of food intake within a meal, as well as signals related to the availability of stored fuels. Work from our laboratory has focused on peripheral and central nervous system studies of behavior and physiology designed to improve our understanding of the role of gut-brain communication in the control of food intake and energy homeostasis. Gastrointestinal administration of nutrients reduces subsequent meal size, suggesting a potent role for peripheral nutrient sensing in the negative feedback control of ingestion. Vagal afferent nerves supply gastrointestinal sites stimulated during food intake, and these nerves are responsive to mechanical and nutrient chemical properties of ingested food. In addition, the presence of nutrients in these gastrointestinal sites stimulates the release of peptides that affect energy intake. These gut peptides also modulate the activity of peripheral gastrointestinal sensory nerves in ways that may contribute to their effects on food intake. In the central nervous system, adiposity hormones and their downstream mediators have been shown to work at both hindbrain and forebrain sites to affect food intake and metabolism. Importantly, recent data has shown that adiposity hormones acting in the brain increase the behavioral and neural potency of feeding inhibitory gastrointestinal stimuli. These data support the suggestion that insensitivity to adiposity hormones in obesity may be characterized by alterations in their ability to modulate the neural processing of food signals important in determining how much food is consumed during a meal.

Magnetotelluric Data, Central Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for Central Yucca Flat, Profile 1, as shown in figure 1. No interpretation of the data is included here.« less

Magnetotelluric Data, North Central Yucca Flat, Nevada Test Site, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.M. Williams; B.D. Rodriguez, and T.H. Asch

2005-11-23

Nuclear weapons are integral to the defense of the United States. The U.S. Department of Energy, as the steward of these devices, must continue to gauge the efficacy of the individual weapons. This could be accomplished by occasional testing at the Nevada Test Site (NTS) in Nevada, northwest of Las Vegas. Yucca Flat Basin is one of the testing areas at the NTS. One issue of concern is the nature of the somewhat poorly constrained pre-Tertiary geology and its effects on ground-water flow in the area subsequent to a nuclear test. Ground-water modelers would like to know more about themore » hydrostratigraphy and geologic structure to support a hydrostratigraphic framework model that is under development for the Yucca Flat Corrective Action Unit (CAU). During 2003, the U.S. Geological Survey (USGS) collected and processed Magnetotelluric (MT) and Audio-magnetotelluric (AMT) data at the Nevada Test Site in and near Yucca Flat to help characterize this pre-Tertiary geology. That work will help to define the character, thickness, and lateral extent of pre-Tertiary confining units. In particular, a major goal has been to define the upper clastic confining unit (UCCU) in the Yucca Flat area. Interpretation will include a three-dimensional (3-D) character analysis and two-dimensional (2-D) resistivity model. The purpose of this report is to release the MT sounding data for north central Yucca Flat, Profile 7, as shown in Figure 1. No interpretation of the data is included here.« less

Toolbox for Research, or how to facilitate a central data management in small-scale research projects.

PubMed

Bialke, Martin; Rau, Henriette; Thamm, Oliver C; Schuldt, Ronny; Penndorf, Peter; Blumentritt, Arne; Gött, Robert; Piegsa, Jens; Bahls, Thomas; Hoffmann, Wolfgang

2018-01-25

In most research projects budget, staff and IT infrastructures are limiting resources. Especially for small-scale registries and cohort studies professional IT support and commercial electronic data capture systems are too expensive. Consequently, these projects use simple local approaches (e.g. Excel) for data capture instead of a central data management including web-based data capture and proper research databases. This leads to manual processes to merge, analyze and, if possible, pseudonymize research data of different study sites. To support multi-site data capture, storage and analyses in small-scall research projects, corresponding requirements were analyzed within the MOSAIC project. Based on the identified requirements, the Toolbox for Research was developed as a flexible software solution for various research scenarios. Additionally, the Toolbox facilitates data integration of research data as well as metadata by performing necessary procedures automatically. Also, Toolbox modules allow the integration of device data. Moreover, separation of personally identifiable information and medical data by using only pseudonyms for storing medical data ensures the compliance to data protection regulations. This pseudonymized data can then be exported in SPSS format in order to enable scientists to prepare reports and analyses. The Toolbox for Research was successfully piloted in the German Burn Registry in 2016 facilitating the documentation of 4350 burn cases at 54 study sites. The Toolbox for Research can be downloaded free of charge from the project website and automatically installed due to the use of Docker technology.

Predicting water table response to rainfall events, central Florida.

PubMed

van Gaalen, J F; Kruse, S; Lafrenz, W B; Burroughs, S M

2013-01-01

A rise in water table in response to a rainfall event is a complex function of permeability, specific yield, antecedent soil-water conditions, water table level, evapotranspiration, vegetation, lateral groundwater flow, and rainfall volume and intensity. Predictions of water table response, however, commonly assume a linear relationship between response and rainfall based on cumulative analysis of water level and rainfall logs. By identifying individual rainfall events and responses, we examine how the response/rainfall ratio varies as a function of antecedent water table level (stage) and rainfall event size. For wells in wetlands and uplands in central Florida, incorporating stage and event size improves forecasting of water table rise by more than 30%, based on 10 years of data. At the 11 sites studied, the water table is generally least responsive to rainfall at smallest and largest rainfall event sizes and at lower stages. At most sites the minimum amount of rainfall required to induce a rise in water table is fairly uniform when the water table is within 50 to 100 cm of land surface. Below this depth, the minimum typically gradually increases with depth. These observations can be qualitatively explained by unsaturated zone flow processes. Overall, response/rainfall ratios are higher in wetlands and lower in uplands, presumably reflecting lower specific yields and greater lateral influx in wetland sites. Pronounced depth variations in rainfall/response ratios appear to correlate with soil layer boundaries, where corroborating data are available. © 2012, The Author(s). Groundwater © 2012, National Ground Water Association.

Real-Time Pretreatment Review Limits Unacceptable Deviations on a Cooperative Group Radiation Therapy Technique Trial: Quality Assurance Results of RTOG 0933

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gondi, Vinai, E-mail: vgondi@chicagocancer.org; University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin; Cui, Yunfeng

2015-03-01

Purpose: RTOG 0933 was a phase II trial of hippocampal avoidance during whole brain radiation therapy for patients with brain metastases. The results demonstrated improvement in short-term memory decline, as compared with historical control individuals, and preservation of quality of life. Integral to the conduct of this trial were quality assurance processes inclusive of pre-enrollment credentialing and pretreatment centralized review of enrolled patients. Methods and Materials: Before enrolling patients, all treating physicians and sites were required to successfully complete a “dry-run” credentialing test. The treating physicians were credentialed based on accuracy of magnetic resonance imaging–computed tomography image fusion and hippocampal andmore » normal tissue contouring, and the sites were credentialed based on protocol-specified dosimetric criteria. Using the same criteria, pretreatment centralized review of enrolled patients was conducted. Physicians enrolling 3 consecutive patients without unacceptable deviations were permitted to enroll further patients without pretreatment review, although their cases were reviewed after treatment. Results: In all, 113 physicians and 84 sites were credentialed. Eight physicians (6.8%) failed hippocampal contouring on the first attempt; 3 were approved on the second attempt. Eight sites (9.5%) failed intensity modulated radiation therapy planning on the first attempt; all were approved on the second attempt. One hundred thirteen patients were enrolled in RTOG 0933; 100 were analyzable. Eighty-seven cases were reviewed before treatment; 5 (5.7%) violated the eligibility criteria, and 21 (24%) had unacceptable deviations. With feedback, 18 cases were approved on the second attempt and 2 cases on the third attempt. One patient was treated off protocol. Twenty-two cases were reviewed after treatment; 1 (4.5%) violated the eligibility criteria, and 5 (23%) had unacceptable deviations. Conclusions: Although >95% of the cases passed the pre-enrollment credentialing, the pretreatment centralized review disqualified 5.7% of reviewed cases, prevented unacceptable deviations in 24% of reviewed cases, and limited the final unacceptable deviation rate to 5%. Thus, pretreatment review is deemed necessary in future hippocampal avoidance trials and is potentially useful in other similarly challenging radiation therapy technique trials.« less

Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex

PubMed Central

Beitel, Ralph E.; Schreiner, Christoph E.; Leake, Patricia A.

2016-01-01

In profoundly deaf cats, behavioral training with intracochlear electric stimulation (ICES) can improve temporal processing in the primary auditory cortex (AI). To investigate whether similar effects are manifest in the auditory midbrain, ICES was initiated in neonatally deafened cats either during development after short durations of deafness (8 wk of age) or in adulthood after long durations of deafness (≥3.5 yr). All of these animals received behaviorally meaningless, “passive” ICES. Some animals also received behavioral training with ICES. Two long-deaf cats received no ICES prior to acute electrophysiological recording. After several months of passive ICES and behavioral training, animals were anesthetized, and neuronal responses to pulse trains of increasing rates were recorded in the central (ICC) and external (ICX) nuclei of the inferior colliculus. Neuronal temporal response patterns (repetition rate coding, minimum latencies, response precision) were compared with results from recordings made in the AI of the same animals (Beitel RE, Vollmer M, Raggio MW, Schreiner CE. J Neurophysiol 106: 944–959, 2011; Vollmer M, Beitel RE. J Neurophysiol 106: 2423–2436, 2011). Passive ICES in long-deaf cats remediated severely degraded temporal processing in the ICC and had no effects in the ICX. In contrast to observations in the AI, behaviorally relevant ICES had no effects on temporal processing in the ICC or ICX, with the single exception of shorter latencies in the ICC in short-deaf cats. The results suggest that independent of deafness duration passive stimulation and behavioral training differentially transform temporal processing in auditory midbrain and cortex, and primary auditory cortex emerges as a pivotal site for behaviorally driven neuronal temporal plasticity in the deaf cat. NEW & NOTEWORTHY Behaviorally relevant vs. passive electric stimulation of the auditory nerve differentially affects neuronal temporal processing in the central nucleus of the inferior colliculus (ICC) and the primary auditory cortex (AI) in profoundly short-deaf and long-deaf cats. Temporal plasticity in the ICC depends on a critical amount of electric stimulation, independent of its behavioral relevance. In contrast, the AI emerges as a pivotal site for behaviorally driven neuronal temporal plasticity in the deaf auditory system. PMID:27733594

Regional bankfull-channel dimensions of non-urban wadeable streams in Indiana

USGS Publications Warehouse

Robinson, Bret A.

2013-01-01

During floods, damage to properties and community infrastructure may result from inundation and the processes of erosion. The damages imparted by erosion are collectively termed the fluvial erosion hazard (FEH), and the Indiana Silver Jackets Multi-agency Hazard Mitigation Taskforce is supporting a program to build tools that will assist Indiana property owners and communities with FEH-mitigation efforts. As part of that program, regional channel-dimension relations are identified for non-urban wadeable streams in Indiana. With a site-selection process that targeted the three largest physiographic regions of the state, field work was completed to measure channel-dimension and channel-geometry characteristics across Indiana. In total, 82 sites were identified for data collection; 25 in the Northern Moraine and Lake region, 31 in the Central Till Plain region, and 26 in the Southern Hills and Lowlands region. Following well established methods, for each data-collection site, effort was applied to identify bankfull stage, determine bankfull-channel dimensions, and document channel-geometry characteristics that allowed for determinations of channel classification. In this report, regional bankfull-channel dimension results are presented as a combination of plots and regression equations that identify the relations between drainage area and the bankfull-channel dimensions of width, mean depth, and cross-sectional area. This investigation found that the channel-dimension data support independent relations for each of the three physiographic regions noted above. Furthermore, these relations show that, for any given drainage area, northern Indiana channels have the smallest predicted dimensions, southern Indiana channels have the largest predicted dimensions, and central Indiana channels are intermediate in their predicted dimensions. When considering the suite of variables that influence bankfull-channel dimensions, it appears that contrasting runoff characteristics between the three physiographic regions may explain much of the inequality observed in the measured channel dimensions. While this investigation targeted non-urban wadeable streams in Indiana, site conditions prevented data collection in some areas. Therefore, application of the results of this study always should include knowledge gained from local observations.

Managing the CMS Data and Monte Carlo Processing during LHC Run 2

NASA Astrophysics Data System (ADS)

Wissing, C.; CMS Collaboration

2017-10-01

In order to cope with the challenges expected during the LHC Run 2 CMS put in a number of enhancements into the main software packages and the tools used for centrally managed processing. In the presentation we will highlight these improvements that allow CMS to deal with the increased trigger output rate, the increased pileup and the evolution in computing technology. The overall system aims at high flexibility, improved operational flexibility and largely automated procedures. The tight coupling of workflow classes to types of sites has been drastically relaxed. Reliable and high-performing networking between most of the computing sites and the successful deployment of a data-federation allow the execution of workflows using remote data access. That required the development of a largely automatized system to assign workflows and to handle necessary pre-staging of data. Another step towards flexibility has been the introduction of one large global HTCondor Pool for all types of processing workflows and analysis jobs. Besides classical Grid resources also some opportunistic resources as well as Cloud resources have been integrated into that Pool, which gives reach to more than 200k CPU cores.

75 FR 54631 - Proposed Approval of the Central Characterization Project's Transuranic Waste Characterization...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Central Characterization Project's Transuranic Waste Characterization Program at the Hanford Site AGENCY...) waste characterization program implemented by the Central Characterization Project (CCP) at the Hanford... characterization of TRU debris waste from Hanford-CCP during an inspection conducted on April 27-29, 2010. Using...

Neural dynamics during repetitive visual stimulation

NASA Astrophysics Data System (ADS)

Tsoneva, Tsvetomira; Garcia-Molina, Gary; Desain, Peter

2015-12-01

Objective. Steady-state visual evoked potentials (SSVEPs), the brain responses to repetitive visual stimulation (RVS), are widely utilized in neuroscience. Their high signal-to-noise ratio and ability to entrain oscillatory brain activity are beneficial for their applications in brain-computer interfaces, investigation of neural processes underlying brain rhythmic activity (steady-state topography) and probing the causal role of brain rhythms in cognition and emotion. This paper aims at analyzing the space and time EEG dynamics in response to RVS at the frequency of stimulation and ongoing rhythms in the delta, theta, alpha, beta, and gamma bands. Approach.We used electroencephalography (EEG) to study the oscillatory brain dynamics during RVS at 10 frequencies in the gamma band (40-60 Hz). We collected an extensive EEG data set from 32 participants and analyzed the RVS evoked and induced responses in the time-frequency domain. Main results. Stable SSVEP over parieto-occipital sites was observed at each of the fundamental frequencies and their harmonics and sub-harmonics. Both the strength and the spatial propagation of the SSVEP response seem sensitive to stimulus frequency. The SSVEP was more localized around the parieto-occipital sites for higher frequencies (>54 Hz) and spread to fronto-central locations for lower frequencies. We observed a strong negative correlation between stimulation frequency and relative power change at that frequency, the first harmonic and the sub-harmonic components over occipital sites. Interestingly, over parietal sites for sub-harmonics a positive correlation of relative power change and stimulation frequency was found. A number of distinct patterns in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (15-30 Hz) bands were also observed. The transient response, from 0 to about 300 ms after stimulation onset, was accompanied by increase in delta and theta power over fronto-central and occipital sites, which returned to baseline after approx. 500 ms. During the steady-state response, we observed alpha band desynchronization over occipital sites and after 500 ms also over frontal sites, while neighboring areas synchronized. The power in beta band over occipital sites increased during the stimulation period, possibly caused by increase in power at sub-harmonic frequencies of stimulation. Gamma power was also enhanced by the stimulation. Significance. These findings have direct implications on the use of RVS and SSVEPs for neural process investigation through steady-state topography, controlled entrainment of brain oscillations and BCIs. A deep understanding of SSVEP propagation in time and space and the link with ongoing brain rhythms is crucial for optimizing the typical SSVEP applications for studying, assisting, or augmenting human cognitive and sensorimotor function.

Pre-movement planning processes in people with congenital mirror movements.

PubMed

Franz, E A; Fu, Y

2017-10-01

Pre-movement processes were investigated in people with Congenital mirrormovement (CMM), a rare disorder in which bilateral movement (mirroring) occurs in the upper distal extremities (primarily the hands and fingers) during intended unilateral movements. Abnormal density of ipsilateral corticospinal projections is an established hallmark of CMM. This study tested whether the Lateralised Readiness Potential (LRP), which reflects movement planning and readiness, is also abnormal in people with CMM. Twenty-eight neurologically-normal controls and 8 people with CMM were tested on a unimanual Go/No-go task while electroencephalography (EEG) was recorded to assess the LRP. No significant group differences were found in reaction time (RT). However, significantly smaller LRP amplitudes were found, on average, in the CMM group compared to Controls at central-motor (C3,C4) sites in stimulus-locked and response-locked epochs; similar group differences were also found at further frontal sites (F3,F4) during response-locked epochs. Abnormal brain activity in pre-movement processes associated with response planning and preparation is present in people with CMM. Aberrant bilateral activity during pre-movement processes is clearly implicated; whether part of the etiology of CMM, or as a mechanism of neuro-compensation, is not yet known. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. II. In vitro and in vivo interactions with benzodiazepine binding sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keane, P.E.; Bachy, A.; Morre, M.

1988-05-01

Tetrazepam is a 1,4-benzodiazepine (BZD) derivative which, in rodents, appears to have very little sedative and ataxic effects. In an attempt to identify the molecular mechanisms underlying this particular pharmacological profile we examined the interaction of tetrazepam with BZD binding sites. Tetrazepam interacted competitively with central and peripheral BZD binding sites and exhibited comparable affinities for both sites. Tetrazepam was approximately one-seventh as potent as diazepam at the central receptor and as potent as diazepam at the peripheral binding site. Tetrazepam did not distinguish type I from type II central BZD receptors, as evidenced by comparable affinities for the cerebellarmore » and hippocampal receptors. In vitro autoradiographic studies showed that tetrazepam displaced (3H)flunitrazepam from rat brain membranes without any clear regional specificity. Like all BZD receptor agonists, tetrazepam exhibited a gamma-aminobutyric acid shift, a photoaffinity shift and potentiated the binding of 35S-t-butyl-bicyclophosphorothionate to rat brain membranes. However, the latter effect was observed at relatively high concentrations of tetrazepam. In vivo, tetrazepam displaced specifically bound (3H)flunitrazepam from mouse brain (ID50, 37 mg/kg p.o. vs 3.5 mg/kg p.o. for diazepam) and from mouse kidney (ID50, 38 mg/kg p.o. vs. 21 mg/kg p.o. for diazepam). It is concluded that tetrazepam is a BZD receptor agonist; the molecular mechanisms which underly the low sedative potential of the drug cannot at present be explained by a particular interaction with either central or peripheral BZD binding sites, but may be related to the drug's relatively weak effect on 35S-t-butyl-bicyclophosphorothionate binding.« less

Strip Clearcutting Did Not Degrade the Site in a Spruce-Fir Forest in Central Maine

Treesearch

Miroslaw M. Czapowskyi; Robert V. Rourke; Robert M. Frank

1977-01-01

Changes in the nutrient concentration in the forest floor and in the mineral soil were assessed on a mature spruce-fir stand in central Maine that had been harvested in 1965 by strip clearcutting. On part of the site, slash was left in place; on other parts it was removed, and on some it was burned. Eight years after the harvest, the clearcut areas tended to have...

Characterization and reclamation assessment for the Central Shops Diesel Storage Facility, Savannah River Site, Aiken, South Carolina

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fliermans, C.B.; Hazen, T.C.; Bledsoe, H.

1993-10-01

The contamination of subsurface terrestrial environments by organic contaminants is a global phenomenon. The remediation of such environments requires innovative assessment techniques and strategies for successful clean-ups. Central Shops Diesel Storage Facility at Savannah River Site was characterized to determine the extent of subsurface diesel fuel contamination using innovative approaches and effective bioremediation techniques for clean-up of the contaminant plume have been established.

Molecular insights into the recruitment of TFIIH to sites of DNA damage

PubMed Central

Oksenych, Valentyn; de Jesus, Bruno Bernardes; Zhovmer, Alexander; Egly, Jean-Marc; Coin, Frédéric

2009-01-01

XPB and XPD subunits of TFIIH are central genome caretakers involved in nucleotide excision repair (NER), although their respective role within this DNA repair pathway remains difficult to delineate. To obtain insight into the function of XPB and XPD, we studied cell lines expressing XPB or XPD ATPase-deficient complexes. We show the involvement of XPB, but not XPD, in the accumulation of TFIIH to sites of DNA damage. Recruitment of TFIIH occurs independently of the helicase activity of XPB, but requires two recently identified motifs, a R-E-D residue loop and a Thumb-like domain. Furthermore, we show that these motifs are specifically involved in the DNA-induced stimulation of the ATPase activity of XPB. Together, our data demonstrate that the recruitment of TFIIH to sites of damage is an active process, under the control of the ATPase motifs of XPB and suggest that this subunit functions as an ATP-driven hook to stabilize the binding of the TFIIH to damaged DNA. PMID:19713942

Immunoreactive GnRH Type I Receptors in the Mouse and Sheep Brain

PubMed Central

Albertson, Asher J.; Navratil, Amy; Mignot, Mallory; Dufourny, Laurence; Cherrington, Brian; Skinner, Donal C.

2008-01-01

GnRH has been implicated in an array of functions outside the neuroendocrine reproductive axis. Previous investigations have reported extensive GnRH binding in numerous sites and this has been supported by in situ hybridization studies reporting GnRH receptor mRNA distribution. The present study on mice and sheep supports and extends these earlier investigations by revealing the distribution of cells immunoreactive for the GnRH receptor. In addition to sites previously shown to express GnRH receptors such as the hippocampus, amygdala and the arcuate nucleus, the improved resolution afforded by immunocytochemistry detected cells in the mitral cell lay of the olfactory bulb as well as the central grey of the mesencephalon. In addition, GnRH receptor immunoreactive neurons in the hippocampus and mesencephalon of the sheep were shown to colocalize with estrogen receptor β. Although GnRH may act at some of these sites to regulate reproductive processes, evidence is accumulating to support an extra-reproductive role for this hypothalamic decapeptide. PMID:18439800

Regulation of E2s: A Role for Additional Ubiquitin Binding Sites?

PubMed

Middleton, Adam J; Wright, Joshua D; Day, Catherine L

2017-11-10

Attachment of ubiquitin to proteins relies on a sophisticated enzyme cascade that is tightly regulated. The machinery of ubiquitylation responds to a range of signals, which remarkably includes ubiquitin itself. Thus, ubiquitin is not only the central player in the ubiquitylation cascade but also a key regulator. The ubiquitin E3 ligases provide specificity to the cascade and often bind the substrate, while the ubiquitin-conjugating enzymes (E2s) have a pivotal role in determining chain linkage and length. Interaction of ubiquitin with the E2 is important for activity, but the weak nature of these contacts has made them hard to identify and study. By reviewing available crystal structures, we identify putative ubiquitin binding sites on E2s, which may enhance E2 processivity and the assembly of chains of a defined linkage. The implications of these new sites are discussed in the context of known E2-ubiquitin interactions. Copyright © 2017 Elsevier Ltd. All rights reserved.

Permanent human occupation of the central Tibetan Plateau in the early Holocene.

PubMed

Meyer, M C; Aldenderfer, M S; Wang, Z; Hoffmann, D L; Dahl, J A; Degering, D; Haas, W R; Schlütz, F

2017-01-06

Current models of the peopling of the higher-elevation zones of the Tibetan Plateau postulate that permanent occupation could only have been facilitated by an agricultural lifeway at ~3.6 thousand calibrated carbon-14 years before present. Here we report a reanalysis of the chronology of the Chusang site, located on the central Tibetan Plateau at an elevation of ~4270 meters above sea level. The minimum age of the site is fixed at ~7.4 thousand years (thorium-230/uranium dating), with a maximum age between ~8.20 and 12.67 thousand calibrated carbon-14 years before present (carbon-14 assays). Travel cost modeling and archaeological data suggest that the site was part of an annual, permanent, preagricultural occupation of the central plateau. These findings challenge current models of the occupation of the Tibetan Plateau. Copyright © 2017, American Association for the Advancement of Science.

Human health exposure assessment for Rocky Mountain Arsenal study area evaluations. Volume 6-E. Central study area exposure assessment. Version 4. 1(volume 6-E). Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The objectives of the Human Health Exposure Assessment include: (1) estimate the type and magnitude of exposures to contaminants; (2) Identify contaminants of concern; (3) Identify sites for remedial action; (4) Recommend sites for the no action remedial alternative; and (5) Provide a basis for detailed characterization of the risk associated with all sites. This document consists of the following: An executive summary. Vol I - Land use and exposed population evaluations. Vol. II III - Toxicity assessment (includes army and shell toxicity profiles). Vol. IV - PPLV Methodology. Vol. V - PPLV Calculations. Vol. VI - Study area exposuremore » analysis A introduction, B Western study ares, C Southern study area, D northern Central study area, E Central study area, F Eastern study area, G South plants study area, and H North plants study area. Vol. VII - Summary exposure assessment.« less

A BiomeBGC-based Evaluation of Dryness Stress of Central European Forests

NASA Astrophysics Data System (ADS)

Buddenbaum, H.; Hientgen, J.; Dotzler, S.; Werner, W.; Hill, J.

2015-04-01

Dryness stress is expected to become a more common problem in central European forests due to the predicted regional climate change. Forest management has to adapt to climate change in time and think ahead several decades in decisions on which tree species to plant at which locations. The summer of 2003 was the most severe dryness event in recent time, but more periods like this are expected. Since forests on different sites react quite differently to drought conditions, we used the process-based growth model BiomeBGC and climate time series from sites all over Germany to simulate the reaction of deciduous and coniferous tree stands in different characteristics of drought stress. Times with exceptionally high values of water vapour pressure deficit coincided with negative modelled values of net primary production (NPP). In addition, in these warmest periods the usually positive relationship between temperature and NPP was inversed, i.e., under stress conditions, more sunlight does not lead to more photosynthesis but to stomatal closure and reduced productivity. Thus we took negative NPP as an indicator for drought stress. In most regions, 2003 was the year with the most intense stress, but the results were quite variable regionally. We used the Modis MOD17 gross and net primary production product time series and MOD12 land cover classification to validate the spatial patterns observed in the model runs and found good agreement between modelled and observed behaviour. Thus, BiomeBGC simulations with realistic site parameterization and climate data in combination with species- and variety-specific ecophysiological constants can be used to assist in decisions on which trees to plant on a given site.

A mathematical model of single target site location by Brownian movement in subcellular compartments.

PubMed

Kuthan, Hartmut

2003-03-07

The location of distinct sites is mandatory for many cellular processes. In the subcompartments of the cell nucleus, only very small numbers of diffusing macromolecules and specific target sites of some types may be present. In this case, we are faced with the Brownian movement of individual macromolecules and their "random search" for single/few specific target sites, rather than bulk-averaged diffusion and multiple sites. In this article, I consider the location of a distant central target site, e.g. a globular protein, by individual macromolecules executing unbiased (i.e. drift-free) random walks in a spherical compartment. For this walk-and-capture model, the closed-form analytic solution of the first passage time probability density function (p.d.f.) has been obtained as well as the first and second moment. In the limit of a large ratio of the radii of the spherical diffusion space and central target, well-known relations for the variance and the first two moments for the exponential p.d.f. were found to hold with high accuracy. These calculations reinforce earlier numerical results and Monte Carlo simulations. A major implication derivable from the model is that non-directed random movement is an effective means for locating single sites in submicron-sized compartments, even when the diffusion coefficients are comparatively small and the diffusing species are present in one copy only. These theoretical conclusions are underscored numerically for effective diffusion constants ranging from 0.5 to 10.0 microm(2) s(-1), which have been reported for a couple of nuclear proteins in their physiological environment. Spherical compartments of submicron size are, for example, the Cajal bodies (size: 0.1-1.0 microm), which are present in 1-5 copies in the cell nucleus. Within a small Cajal body of radius 0.1 microm a single diffusing protein molecule (with D=0.5 microm(2) s(-1)) would encounter a medium-sized protein of radius 2.5 nm within 1 s with a probability near certainty (p=0.98).

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein (G) gene in central Vietnam.

PubMed

Yoshihara, Keisuke; Le, Minh Nhat; Nagasawa, Koo; Tsukagoshi, Hiroyuki; Nguyen, Hien Anh; Toizumi, Michiko; Moriuchi, Hiroyuki; Hashizume, Masahiro; Ariyoshi, Koya; Dang, Duc Anh; Kimura, Hirokazu; Yoshida, Lay-Myint

2016-11-01

We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains. We also estimated the N-glycosylation sites within G gene hypervariable region. Amino acid substitutions under positive and negative selection pressure were examined using Conservative Single Likelihood Ancestor Counting (SLAC), Fixed Effects Likelihood (FEL), Internal Fixed Effects Likelihood (IFEL) and Mixed Effects Model for Episodic Diversifying Selection (MEME) models. The majority of central Vietnam ON1 strains detected in 2012 were classified into lineage 1 with few positively selected substitutions. As for the Vietnamese NA1 strains, four lineages were circulating during the study period with a few positive selection sites. Shifting patterns of the predominantly circulating NA1 lineage were observed in each year during the investigation period. Median p-distance of central Vietnam NA1 strains was wider (p-distance=0.028) than that of ON1 (p-distance=0.012). The molecular evolutionary rate of central Vietnam ON1 strains was estimated to be 2.55×10 -2 (substitutions/site/year) and was faster than NA1 (7.12×10 -3 (substitutions/site/year)). Interestingly, the evolutionary rates of both genotypes ON1 and NA1 strains from central Vietnam were faster than the global strains respectively. Furthermore, the shifts of N-glycosylation pattern within the G gene 3rd hypervariable region of Vietnamese NA1 strains were observed in each year. BSP analysis indicated the rapid growth of RSV-A effective population size in early 2012. These results suggested that the molecular evolution of RSV-A G gene detected in central Vietnam was fast with unique evolutionary dynamics. Copyright © 2016 Elsevier B.V. All rights reserved.

The contribution of the Global Change Observatory Central Asia to seismic hazard and risk assessment in the Central Asian region

NASA Astrophysics Data System (ADS)

Parolai, S.; Bindi, D.; Haberland, C. A.; Pittore, M.; Pilz, M.; Rosenau, M.; Schurr, B.; Wieland, M.; Yuan, X.

2012-12-01

Central Asia has one of the world's highest levels of earthquake hazard, owing to its exceptionally high deformation rates. Moreover, vulnerability to natural disasters in general is increasing, due to rising populations and a growing dependence on complex lifelines and technology. Therefore, there is an urgent need to undertake seismic hazard and risk assessment in this region, while at the same time improving upon existing methodologies, including the consideration of temporal variability in the seismic hazard, and in structural and social vulnerability. Over the last few years, the German Research Center for Geosciences (GFZ), in collaboration with local partners, has initiated a number of scientific activities within the framework of the Global Change Observatory Central Asia (GCO-CA). The work is divided into projects with specific concerns: - The installation and maintenance of the Central-Asian Real-time Earthquake MOnitoring Network (CAREMON) and the setup of a permanent wireless mesh network for structural health monitoring in Bishkek. - The TIPAGE and TIPTIMON projects focus on the geodynamics of the Tien-Shan, Pamir and Hindu Kush region, the deepest and most active intra-continental subduction zone in the world. The work covers time scales from millions of years to short-term snapshots based on geophysical measurements of seismotectonic activity and of the physical properties of the crust and upper mantle, as well as their coupling with other surface processes (e.g., landslides). - Existing risk analysis methods assume time-independent earthquake hazard and risk, although temporal changes are likely to occur due to, for example, co- and post-seismic changes in the regional stress field. We therefore aim to develop systematic time-dependent hazard and risk analysis methods in order to undertake the temporal quantification of earthquake activity (PROGRESS). - To improve seismic hazard assessment for better loss estimation, detailed site effects studies are necessary. Temporary seismic networks have been installed in several Central Asian cities (Bishkek and Karakol, Kyrgyzstan; Dushanbe, Tajikistan; Tashkent, Uzbekistan) within the framework of the Earthquake Model Central Asia (EMCA), a regional program of the Global Earthquake Model (GEM). The empirically estimated site effects have already helped to improve real-time risk scenarios for Bishkek and will be applied to other major cities. - A crucial requirement for disaster risk reduction involves the analysis of the vulnerability of existing building inventories. Whereas traditional approaches are very time- and cost-consuming, and even impossible given the high rate of urbanization in Central Asian capitals, our integrated approach is based on satellite remote sensing and ground-based omni-directional imaging, providing building inventories and thus structural vulnerability over large areas (EMCA, GEM-IDCT). All mentioned activities are carried out within the framework of cooperation between GFZ and regional national institutes, in particular the Central Asian Institute for Applied Geosciences. Altogether, this comprehensive and long-term risk analyses and research program will lead to a better understanding of the coupling of endogene and exogene processes and the identification of their impact on society.

Changes in Fire-Derived Soil Black Carbon Storage in a Sub-humid Woodland

NASA Astrophysics Data System (ADS)

White, J. D.; Yao, J.; Murray, D. B.; Hockaday, W. C.

2014-12-01

Fire-derived black carbon (BC) in soil, including charcoal, represents a potentially important fraction of terrestrial carbon cycling due to its presumed long persistence in soil. Interpretation of site BC retention is important for assessing feedbacks to ecosystem processes including nutrient and water cycling. However, interaction between vegetation disturbance, BC formation, and off site transport may exist that complicate interpretation of BC addition to soils from wildfire or prescribed burns directly. To investigate the relationship between disturbance and site retention on soil BC, we determined BC concentrations for a woodland in central Texas, USA, from study plots in hilly terrain with a fire scar dendrochronology spanning 100 years. BC values were determined from 13C nuclear magnetic resonance (NMR) spectroscopy. Estimated values showed mean BC concentration of 2.73 ± 3.06 g BC kg-1 (0.91 ± 0.51 kg BC m-2) for sites with fire occurrence within the last 40 years compared with BC values of1.21 ± 1.70 g BC kg-1 soil (0.18 ± 0.14 kg BC m-2) for sites with fire 40 - 100 years ago. Sites with no tree ring evidence of fire during the last 100 years had the lowest mean soil BC concentration of 0.05 ± 0.11 g BC kg-1 (0.02 ± 0.03 kg BC m-2). Molecular proxies of stability (lignin/N) and decomposition (Alkyl C/O-Alky C) showed no differences across the sites, indicating that low potential for BC mineralization. Modeled soil erosion and time since fire from fire scar data showed that soil BC concentrations were inversely correlated. A modified the ecosystem process model, Biome-BGC, was also used simulate the effects of fire disturbance with different severities and seasonality on C cycling related to the BC production, effect on soil water availability, and off-site transport. Results showed that BC impacts on ecosystem processes, including net ecosystem exchange and leaf area development, were predominantly related to fire frequency. Site BC loss rates were affected by initial slope-affected erosion, fire severity, vegetation type, and rate of vegetation recovery. The simulation results showed that fire types, such as high severity, was generally associated with low site BC retention related to low vertical transfer of BC into soils, buoyancy of BC particles, and surface runoff from unvegetated soils.

An Optimal Centralized Carbon Dioxide Repository for Florida, USA

PubMed Central

Poiencot, Brandon; Brown, Christopher

2011-01-01

For over a decade, the United States Department of Energy, and engineers, geologists, and scientists from all over the world have investigated the potential for reducing atmospheric carbon emissions through carbon sequestration. Numerous reports exist analyzing the potential for sequestering carbon dioxide at various sites around the globe, but none have identified the potential for a statewide system in Florida, USA. In 2005, 83% of Florida’s electrical energy was produced by natural gas, coal, or oil (e.g., fossil fuels), from power plants spread across the state. In addition, only limited research has been completed on evaluating optimal pipeline transportation networks to centralized carbon dioxide repositories. This paper describes the feasibility and preliminary locations for an optimal centralized Florida-wide carbon sequestration repository. Linear programming optimization modeling is used to plan and route an idealized pipeline network to existing Florida power plants. Further analysis of the subsurface geology in these general locations will provide insight into the suitability of the subsurface conditions and the available capacity for carbon sequestration at selected possible repository sites. The identification of the most favorable site(s) is also presented. PMID:21695024

An optimal centralized carbon dioxide repository for Florida, USA.

PubMed

Poiencot, Brandon; Brown, Christopher

2011-04-01

For over a decade, the United States Department of Energy, and engineers, geologists, and scientists from all over the world have investigated the potential for reducing atmospheric carbon emissions through carbon sequestration. Numerous reports exist analyzing the potential for sequestering carbon dioxide at various sites around the globe, but none have identified the potential for a statewide system in Florida, USA. In 2005, 83% of Florida's electrical energy was produced by natural gas, coal, or oil (e.g., fossil fuels), from power plants spread across the state. In addition, only limited research has been completed on evaluating optimal pipeline transportation networks to centralized carbon dioxide repositories. This paper describes the feasibility and preliminary locations for an optimal centralized Florida-wide carbon sequestration repository. Linear programming optimization modeling is used to plan and route an idealized pipeline network to existing Florida power plants. Further analysis of the subsurface geology in these general locations will provide insight into the suitability of the subsurface conditions and the available capacity for carbon sequestration at selected possible repository sites. The identification of the most favorable site(s) is also presented.

Influence of Vegetation Cover on Rain Pulse Responses in Semi-Arid Savannas in Central Texas

NASA Astrophysics Data System (ADS)

Litvak, M.; Heilman, J.; McInnes, K.; Thijs, A.; Kjelgaard, J.

2007-12-01

Savannas in central Texas are dominated by live oak (Quercus virginiana) and Ashe juniper (Juniperus asheii) underlain by perennial, C3/C4 grasslands, and are increasingly becoming juniper and mesquite dominated due to overgrazing and suppression of wildfires. Since 2004, we have been investigating how carbon, water and energy exchange in these rain-limited savannas respond to rainfall variability and this observed vegetation change. In semi-arid regions, rainfall pulses provide inputs of soil moisture and trigger biotic activity in the form of plant gas exchange and microbial metabolism as well as water dependent physical processes in the soil. Each of these components has a different characteristic response curve to soil moisture and integrates soil water content over a different range of depths. Here we focus on examining how the observed increase of woody species in central Texas savannas alters the response of net ecosystem exchange and its components, ecosystem respiration and gross ecosystem exchange, to rain pulses. Using data we have collected over the last three years from three Ameriflux tower sites at Freeman Ranch near San Marcos, TX (C3/C4 grassland, juniper/mesquite savanna with 50 percent woody cover, and oak/juniper woodland), we quantify the responses of both ecosystem respiration and daily carbon uptake to rainfall pulses throughout the year. Specifically, we look at the enhancement and persistence of ecosystem respiration and carbon uptake responses following a pulse, and isolate the main controlling factors on the observed response: seasonality, antecedent soil moisture and temperature, or previous pulses. In all three land covers, the general response to precipitation pulses is a respiration pulse followed by an increase in total carbon uptake. Differences in pulse responses observed at the savanna site compared to the grassland and woodland sites can be explained, in part, by the observed differences in rooting structure and photosynthetic capacity due to differences in plant functional groups and leaf area index. The woodland site is most sensitive to winter pulses in terms of enhanced sink strength following pulses and is dependent on both temperature and pulse size. Both the grassland and shrubland sites show greater sink strength following summer pulses, rather than winter pulses. Both the ecosystem respiration and net uptake responses in all three sites are dependent upon whether there was shallow versus deep soil moisture recharge following pulses. Implications for the influence of future climate change on carbon dynamics in these savanna ecosystems will be discussed.

Bilateral widespread mechanical pain hypersensitivity as sign of central sensitization in patients with cluster headache.

PubMed

Fernández-de-Las-Peñas, César; Ortega-Santiago, Ricardo; Cuadrado, María L; López-de-Silanes, Carlos; Pareja, Juan A

2011-03-01

To investigate bilateral widespread pressure pain hyperalgesia in deep tissues over symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with cluster headache (CH). Central sensitization is claimed to play a relevant role in CH. No study has previously searched for widespread pressure hyperalgesia in deep tissues over both symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with CH. Sixteen men (mean age: 43 ± 11 years) with CH in a remission phase and 16 matched controls were recruited. Pressure pain thresholds (PPTs) were bilaterally measured over the supra-orbital (V1), infra-orbital (V2), mental (V3), median (C5), radial (C6), and ulnar (C7) nerves, C5-C6 zygapophyseal joint, mastoid process, and tibialis anterior muscle by an assessor blinded to the subjects' condition. The results showed that PPT levels were significantly decreased bilaterally in patients with CH as compared with healthy controls (all sites, P < .001). A greater degree of sensitization over the mastoid process (P < .001) and a lower degree of sensitization over the tibialis anterior muscle (P < .01) was found. Our findings revealed bilateral widespread pressure pain hypersensitivity in patients with CH confirming the presence of central sensitization mechanisms in this headache condition. © 2010 American Headache Society.

Ants as a measure of effectiveness of habitat conservation planning in southern California

USGS Publications Warehouse

Mitrovich, Milan J.; Matsuda, Tritia; Pease, Krista H.; Fisher, Robert N.

2010-01-01

In the United States multispecies habitat conservation plans were meant to be the solution to conflicts between economic development and protection of biological diversity. Although now widely applied, questions exist concerning the scientific credibility of the conservation planning process and effectiveness of the plans. We used ants to assess performance of one of the first regional conservation plans developed in the United States, the Orange County Central-Coastal Natural Community Conservation Plan (NCCP), in meeting its broader conservation objectives of biodiversity and ecosystem-level protection. We collected pitfall data on ants for over 3 years on 172 sites established across a network of conservation lands in coastal southern California. Although recovered native ant diversity for the study area was high, site-occupancy models indicated the invasive and ecologically disruptive Argentine ant ( Linepithema humile) was present at 29% of sites, and sites located within 200 m of urban and agricultural areas were more likely to have been invaded. Within invaded sites, native ants were largely displaced, and their median species richness declined by more than 60% compared with uninvaded sites. At the time of planning, 24% of the 15,133-ha reserve system established by Orange County NCCP fell within 200 m of an urban or agricultural edge. With complete build out of lands surrounding the reserve, the proportion of the reserve system vulnerable to invasion will grow to 44%. Our data indicate that simply protecting designated areas from development is not enough. If habitat conservation plans are to fulfill their conservation promise of ecosystem-level protection, a more-integrated and systematic approach to the process of habitat conservation planning is needed.

77 FR 8806 - Foreign-Trade Zone 183-Austin, TX; Application for Reorganization Under the Alternative Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Gardner Road, Austin; Site 2 (50 acres)--Balcones Research site located in north central Austin at the... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket 8-2012] Foreign-Trade Zone 183--Austin, TX; Application for Reorganization Under the Alternative Site Framework An application has been...

76 FR 73587 - Foreign-Trade Zone 183-Austin, Tx; Site Renumbering Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 183--Austin, Tx; Site... Research site located in north central Austin at the intersection of Burnett Road and Longhorn Boulevard... (Board Order 1366). FTZ 183 currently consists of 8 ``sites'' totaling some 2,818 acres in the Austin...

The importance of site quality

Treesearch

David L. Graney

1989-01-01

Yield and quality of central hardwoods depend greatly on the site. So, first off you should determine the site quality of your land for a variety of tree species. This information will allow you to compare yield and value so you can favor the species best suited for each site. Knowing site quality will help you determine what levels of management intensity and...

9. Smoke flue coming through Roundhouse roof. Central of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Smoke flue coming through Roundhouse roof. - Central of Georgia Railway, Savannah Repair Shops & Terminal Facilities, Roundhouse, Site Bounded by West Broad, Jones, West Boundary & Hull, Savannah, Chatham County, GA

Comparisons of Traffic-Related Ultrafine Particle Number Concentrations Measured in Two Urban Areas by Central, Residential, and Mobile Monitoring.

PubMed

Simon, Matthew C; Hudda, Neelakshi; Naumova, Elena N; Levy, Jonathan I; Brugge, Doug; Durant, John L

2017-11-01

Traffic-related ultrafine particles (UFP; <100 nanometers diameter) are ubiquitous in urban air. While studies have shown that UFP are toxic, epidemiological evidence of health effects, which is needed to inform risk assessment at the population scale, is limited due to challenges of accurately estimating UFP exposures. Epidemiologic studies often use empirical models to estimate UFP exposures; however, the monitoring strategies upon which the models are based have varied between studies. Our study compares particle number concentrations (PNC; a proxy for UFP) measured by three different monitoring approaches (central-site, short-term residential-site, and mobile on-road monitoring) in two study areas in metropolitan Boston (MA, USA). Our objectives were to quantify ambient PNC differences between the three monitoring platforms, compare the temporal patterns and the spatial heterogeneity of PNC between the monitoring platforms, and identify factors that affect correlations across the platforms. We collected >12,000 hours of measurements at the central sites, 1,000 hours of measurements at each of 20 residential sites in the two study areas, and >120 hours of mobile measurements over the course of ~1 year in each study area. Our results show differences between the monitoring strategies: mean one-minute PNC on-roads were higher (64,000 and 32,000 particles/cm 3 in Boston and Chelsea, respectively) compared to central-site measurements (23,000 and 19,000 particles/cm 3 ) and both were higher than at residences (14,000 and 15,000 particles/cm 3 ). Temporal correlations and spatial heterogeneity also differed between the platforms. Temporal correlations were generally highest between central and residential sites, and lowest between central-site and on-road measurements. We observed the greatest spatial heterogeneity across monitoring platforms during the morning rush hours (06:00-09:00) and the lowest during the overnight hours (18:00-06:00). Longer averaging times (days and hours vs. minutes) increased temporal correlations (Pearson correlations were 0.69 and 0.60 vs. 0.39 in Boston; 0.71 and 0.61 vs. 0.45 in Chelsea) and reduced spatial heterogeneity (coefficients of divergence were 0.24 and 0.29 vs. 0.33 in Boston; 0.20 and 0.27 vs. 0.31 in Chelsea). Our results suggest that combining stationary and mobile monitoring may lead to improved characterization of UFP in urban areas and thereby lead to improved exposure assignment for epidemiology studies.

Cartographic modeling of heterogeneous landscape for footprint analysis of Eddy Covariance Measurements (Central Forest and Central Chernozem reserves, Russia)

NASA Astrophysics Data System (ADS)

Kozlov, Daniil

2014-05-01

The topographical, soil and vegetation maps of FLUXNET study areas are widely used for interpretation of eddy covariance measurements, for calibration of biogeochemical models and for making regional assessments of carbon balance. The poster presents methodological problems and results of ecosystem mapping using GIS, remote sensing, statistical and field methods on the example of two RusFluxNet sites in the Central Forest (33° E, 56°30'N) and Central Chernozem (36°10' E, 51°36'N) reserves. In the Central Forest reserve tacheometric measurements were used for topographical and peat surveys of bogged sphagnum spruce forest of 20-hectare area. Its common borders and its areas affected by windfall were determined. The supplies and spatial distribution of organic matter were obtained. The datasets of groundwater monitoring measurements on ten wells were compared with each other and the analysis of spatial and temporal groundwater variability was performed. The map of typical ecosystems of the reserve and its surroundings was created on the basis of analysis of multi-temporal Landsat images. In the Central Chernozem reserve the GNSS topographical survey was used for flux tower footprint mapping (22 ha). The features of microrelief predetermine development of different soils within the footprint. Close relationship between soil (73 drilling site) and terrain attributes (DEM with 2.5 m) allowed to build maps of soils and soil properties: carbon content, bulk density, upper boundary of secondary carbonates. Position for chamber-based soil respiration measurements was defined on the basis of these maps. The detailed geodetic and soil surveys of virgin lands and plowland were performed in order to estimate the effect of agrogenic processes such as dehumification, compaction and erosion on soils during the whole period of agricultural use of Central Chernozem reserve area and around. The choice of analogous soils was based on the similarity of their position within the landscape as judged from the terrain attributes of the DEM. The dynamics of soil cover during the last 50 years was estimated on the basis of repetitive detailed surveys of the five key plots conducted in 1963, 1984 and 2013. All results of this study and map analysis conclusions are presented in the poster.

Quantitation of Contacts Among Sensory, Motor, and Serotonergic Neurons in the Pedal Ganglion of Aplysia

PubMed Central

Zhang, Han; Wainwright, Marcy; Byrne, John H.; Cleary, Leonard J.

2003-01-01

Present models of long-term sensitization in Aplysia californica indicate that the enhanced behavioral response is due, at least in part, to outgrowth of sensory neurons mediating defensive withdrawal reflexes. Presumably, this outgrowth strengthens pre-existing connections by formation of newsynapses with follower neurons. However, the relationship between the number of sensorimotor contacts and the physiological strength of the connection has never been examined in intact ganglia. As a first step in addressing this issue, we used confocal microscopy to examine sites of contact between sensory and motor neurons in naive animals. Our results revealed relatively fewcontacts between physiologically connected cells. In addition, the number of contact sites was proportional to the amplitude of the EPSP elicited in the follower motor neuron by direct stimulation of the sensory neuron. This is the first time such a correlation has been observed in the central nervous system. Serotonin is the neurotransmitter most closely examined for its role in modulating synaptic strength at the sensorimotor synapse. However, the structural relationship of serotonergic processes and sensorimotor synapses has never been examined. Surprisingly, serotonergic processes usually made contact with sensory and motor neurons at sites located relatively distant from the sensorimotor synapse. This result implies that heterosynaptic regulation is due to nondirected release of serotonin into the neuropil. PMID:14557611

The influence of geomorphology on the role of women at artisanal and small-scale mine sites

USGS Publications Warehouse

Malpeli, Katherine C.; Chirico, Peter G.

2013-01-01

The geologic and geomorphic expressions of a mineral deposit determine its location, size, and accessibility, characteristics which in turn greatly influence the success of artisans mining the deposit. Despite this critical information, which can be garnered through studying the surficial physical expression of a deposit, the geologic and geomorphic sciences have been largely overlooked in artisanal mining-related research. This study demonstrates that a correlation exists between the roles of female miners at artisanal diamond and gold mining sites in western and central Africa and the physical expression of the deposits. Typically, women perform ore processing and ancillary roles at mine sites. On occasion, however, women participate in the extraction process itself. Women were found to participate in the extraction of ore only when a deposit had a thin overburden layer, thus rendering the mineralized ore more accessible. When deposits required a significant degree of manual labour to access the ore due to thick overburden layers, women were typically relegated to other roles. The identification of this link encourages the establishment of an alternative research avenue in which the physical and social sciences merge to better inform policymakers, so that the most appropriate artisanal mining assistance programs can be developed and implemented.

Effect of Agricultural Practices on Hydrology and Water Chemistry in a Small Irrigated Catchment, Yakima River Basin, Washington

USGS Publications Warehouse

McCarthy, Kathleen A.; Johnson, Henry M.

2009-01-01

The role of irrigation and artificial drainage in the hydrologic cycle and the transport of solutes in a small agricultural catchment in central Washington's Yakima Valley were explored using hydrologic, chemical, isotopic, age-dating, and mineralogical data from several environmental compartments, including stream water, ground water, overland flow, and streambed pore water. A conceptual understanding of catchment hydrology and solute transport was developed and an inverse end-member mixing analysis was used to further explore the effects of agriculture in this small catchment. The median concentrations of major solutes and nitrates were similar for the single field site and for the catchment outflow site, indicating that the net effects of transport processes for these constituents were similar at both scales. However, concentrations of nutrients were different at the two sites, suggesting that field-scale variations in agricultural practices as well as nearstream and instream biochemical processes are important components of agricultural chemical transformation and transport in this catchment. This work indicates that irrigation coupled with artificial drainage networks may exacerbate the ecological effects of agricultural runoff by increasing direct connectivity between fields and streams and minimizing potentially mitigating effects (denitrification and dilution, for example) of longer subsurface pathways.

Landscape dynamics assessment of dry climatic zones on the Baikal-Gobi transect from NDVI time series and field investigations data

NASA Astrophysics Data System (ADS)

Sayapina, D. O.; Zharnikova, M. A.; Tsydypov, B. Z.; Sodnomov, B. V.; Garmaev, E. Zh

2016-11-01

Starting in the eighties of the 20th century, the scientists of the Baikal Institute of Nature Management (BINM SB RAS) have been conducting field observations of the Transbaikalia geosystems transformation due to the change of climate and nature management. An utmost importance is placed on the study of a negative response of the land geosystems. This is shown through their deterioration, degradation, and desertification in particular. Through the years of research (1985-2015) in dry areas of the north of Central Asia, the scientists of the BINM SB RAS established a network of key sites for contact monitoring of the status and dynamics of the geosystems and the negative natural-anthropogenic processes along the Baikal-Gobi meridional transect (51-44° N, 105-107° E). The monitoring of the status and dynamics of the vegetation cover of some key sites is conducted by processing and analysis of multitemporal and multispectral Landsat and MODIS Terra imagery. An automatic analysis of the time variation of NDVI and a comparison with the progress of the index in the previous seasons are performed. The landscape indication of the key sites is made on the basis of satellite imagery and complete geobotanical descriptions. Landscape profiles and facies maps with natural boundaries are created.

Data systems for science integration within the Atmospheric Radiation Measurement Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gracio, D.K.; Hatfield, L.D.; Yates, K.R.

The Atmospheric Radiation Measurement (ARM) Program was developed by the US Department of Energy to support the goals and mission of the US Global Change Research Program. The purpose of the ARM program is to improve the predictive capabilities of General Circulation Models (GCMs) in their treatment of clouds and radiative transfer effects. Three experimental testbeds were designed for the deployment of instruments to collect atmospheric data used to drive the GCMs. Each site, known as a Cloud and Radiation Testbed (CART), consists of a highly available, redundant data system for the collection of data from a variety of instrumentation.more » The first CART site was deployed in April 1992 in the Southern Great Plains (SGP), Lamont, Oklahoma, with the other two sites to follow in early 1996 in the Tropical Western Pacific (TWP) and in 1997 on the North Slope of Alaska (NSA). Approximately 1.5 GB of data are transferred per day via the Internet from the CART sites, and external data sources to the ARM Experiment Center (EC) at Pacific Northwest Laboratory in Richland, Washington. The Experimental Center is central to the ARM data path and provides for the collection, processing, analysis and delivery of ARM data. Data from the CART sites from a variety of instrumentation, observational systems and from external data sources are transferred to the Experiment Center. The EC processes these data streams on a continuous basis to provide derived data products to the ARM Science Team in near real-time while maintaining a three-month running archive of data.« less

High-resolution analyses reveal structural diversity patterns of microbial communities in Chromite Ore Processing Residue (COPR) contaminated soils.

PubMed

Min, Xiaobo; Wang, Yangyang; Chai, Liyuan; Yang, Zhihui; Liao, Qi

2017-09-01

To explore how heavy metal contamination in Chromite Ore Processing Residue (COPR) disposal sites determine the dissimilarities of indigenous microbial communities, 16S rRNA gene MiSeq sequencing and advanced statistical methods were applied. 13 soil samples were collected from three COPR disposal sites in Mouding of southwestern, Shangnan of northwestern and Yima of central China. The results of analyses of variance (ANOVA), similarities (ANOSIM), and non-metric multidimensional scaling (NMDS) showed that the structural diversity of the microbial communities in the samples with high total chromium (Cr) content (more than 300 mg kg -1 ; High group) were significantly lesser than in the Low group (less than 90 mg kg -1 ) regardless of their geographical distribution. But their diversity had virtually rehabilitated under the pressures of long-term metal contamination. Furthermore, the similarity percentage (SIMPER) analysis indicated that the major dissimilarity contributors Micrococcaceae, Delftia, and Streptophyta, possibly having Cr(VI)-resistant and/or Cr(VI)-reducing capability, were dominant in the High group, while Ramlibacter and Gemmatimonas with potential resistances to other heavy metals were prevalent in the Low group. In addition, the multivariate regression tree (MRT), aggregated boosted tree (ABT), and Mantel test revealed that total Cr content affiliated with Cr(VI) was the principal factor shaping the dissimilarities between the soil microbial communities in the COPR sites. Our findings provide a deep insight of the influence of these heavy metals on the microbial communities in the COPR disposal sites and will facilitate bioremediation on such site. Copyright © 2017 Elsevier Ltd. All rights reserved.

Mitochondrial Physiology in the Major Arbovirus Vector Aedes aegypti: Substrate Preferences and Sexual Differences Define Respiratory Capacity and Superoxide Production

PubMed Central

Soares, Juliana B. R. Correa; Gaviraghi, Alessandro; Oliveira, Marcus F.

2015-01-01

Adult females of Aedes aegypti are facultative blood sucking insects and vectors of Dengue and yellow fever viruses. Insect dispersal plays a central role in disease transmission and the extremely high energy demand posed by flight is accomplished by a very efficient oxidative phosphorylation process, which take place within flight muscle mitochondria. These organelles play a central role in energy metabolism, interconnecting nutrient oxidation to ATP synthesis, but also represent an important site of cellular superoxide production. Given the importance of mitochondria to cell physiology, and the potential contributions of this organelle for A. aegypti biology and vectorial capacity, here, we conducted a systematic assessment of mitochondrial physiology in flight muscle of young adult A. aegypti fed exclusively with sugar. This was carried out by determining the activities of mitochondrial enzymes, the substrate preferences to sustain respiration, the mitochondrial bioenergetic efficiency and capacity, in both mitochondria-enriched preparations and mechanically permeabilized flight muscle in both sexes. We also determined the substrates preferences to promote mitochondrial superoxide generation and the main sites where it is produced within this organelle. We observed that respiration in A. aegypti mitochondria was essentially driven by complex I and glycerol 3 phosphate dehydrogenase substrates, which promoted distinct mitochondrial bioenergetic capacities, but with preserved efficiencies. Respiration mediated by proline oxidation in female mitochondria was strikingly higher than in males. Mitochondrial superoxide production was essentially mediated through proline and glycerol 3 phosphate oxidation, which took place at sites other than complex I. Finally, differences in mitochondrial superoxide production among sexes were only observed in male oxidizing glycerol 3 phosphate, exhibiting higher rates than in female. Together, these data represent a significant step towards the understanding of fundamental mitochondrial processes in A. aegypti, with potential implications for its physiology and vectorial capacity. PMID:25803027

Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.

PubMed

Rout, Manoj K; Lee, Brian L; Lin, Aiyang; Xiao, Wei; Spyracopoulos, Leo

2018-05-03

The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps by a three-component enzyme system. Ubiquitination, or E2 enzymes, catalyze the central step by facilitating reaction of a target protein lysine with the C-terminus of Ub that is attached to the active site cysteine of the E2 through a thioester bond. E2 reactivity is modulated by dynamics of an active site gate, whose central residue packs against the active site cysteine in a closed conformation. Interestingly, for the E2 Ubc13, which specifically catalyzes K63-linked ubiquitination, the central gate residue adopts an open conformation. We set out to determine if active site gate dynamics play a role in catalysis for E2-25K, which adopts the canonical, closed gate conformation, and which selectively synthesizes K48-linked ubiquitin chains. Gate dynamics were characterized using mutagenesis of key residues, combined with enzyme kinetics measurements, and main chain NMR relaxation. The experimental data were interpreted with all atom MD simulations. The data indicate that active site gate opening and closing rates for E2-25K are precisely balanced.

ARM - Midlatitude Continental Convective Clouds (jensen-sonde)

DOE Data Explorer

Jensen, Mike; Comstock, Jennifer; Genio, Anthony Del; Giangrande, Scott; Kollias, Pavlos

2012-01-19

A major component of the Mid-latitude Continental Convective Clouds Experiment (MC3E) field campaign was the deployment of an enhanced radiosonde array designed to capture the vertical profile of atmospheric state variables (pressure, temperature, humidity wind speed and wind direction) for the purpose of deriving the large-scale forcing for use in modeling studies. The radiosonde array included six sites (enhanced Central Facility [CF-1] plus five new sites) launching radiosondes at 3-6 hour sampling intervals. The network will cover an area of approximately (300)2 km2 with five outer sounding launch sites and one central launch location. The five outer sounding launch sites are: S01 Pratt, KS [ 37.7oN, 98.75oW]; S02 Chanute, KS [37.674, 95.488]; S03 Vici, Oklahoma [36.071, -99.204]; S04 Morris, Oklahoma [35.687, -95.856]; and S05 Purcell, Oklahoma [34.985, -97.522]. Soundings from the SGP Central Facility during MC3E can be retrieved from the regular ARM archive. During routine MC3E operations 4 radiosondes were launched from each of these sites (approx. 0130, 0730, 1330 and 1930 UTC). On days that were forecast to be convective up to four additional launches were launched at each site (approx. 0430, 1030, 1630, 2230 UTC). There were a total of approximately 14 of these high frequency launch days over the course of the experiment.

Floods of May 1981 in west-central Montana

USGS Publications Warehouse

Parrett, Charles; Omang, R.J.; Hull, J.A.; Fassler, John W.

1982-01-01

Extensive flooding occurred in west-central Montana during May 22-23, 1981, as a result of a series of rainstorms. Flooding was particularly severe in the communities of East Helena, Belt, and Deer Lodge. Although no lives were lost, total flood damages were estimated by the Montana Disaster Emergency Services Division to be in excess of $30 million. Peak discharges were determined at 75 sites in the flooded area. At 25 sites the May 1981 peak discharge exceeded the computed 100-year frequency flood, and at 29 sites, where previous flow records are available, the May 1981 peak discharge exceeded the previous peak of record. (USGS)

A critical review of the German Paleolithic hominin record.

PubMed

Street, Martin; Terberger, Thomas; Orschiedt, Jörg

2006-12-01

We review the hominin fossil record from western Central Europe in light of the recent major revisions of the geochronological context. The mandible from Mauer (Homo heidelbergensis), dated to circa 500,000 years ago, continues to represent the earliest German hominin and may coincide with the occupation of Europe north of the high alpine mountain chains. Only limited new evidence is available for the Middle Pleistocene, mostly in the form of skull fragments, a pattern that may relate to taphonomic processes. These finds and their ages suggest the gradual evolution of a suite of Neandertal features during this period. Despite new finds of classic Neandertals, there is no clear proof for Neandertal burial from Germany. Alternatively, cut marks on a skull fragment from the Neandertal type site suggest special treatment of that individual. New Accelerator Mass Spectrometry (AMS) radiocarbon dates of previous finds leave little reliably dated evidence for anatomically modern humans (AMH) in Europe before 30,000 BP; the remains from Hahnöfersand, Binshof-Speyer, Paderborn-Sande, and Vogelherd are now of Holocene age. Thus, a correlation of AMH with the Aurignacian remains to be proven, and the general idea of a long coexistence of Neandertals and AMH in Europe may be questioned. In western Central Europe, evidence of Gravettian human fossils is also very limited, although a new double grave from lower Austria may be relevant. The only dated burial from the German Upper Paleolithic (from Mittlere Klause) falls into a time period (circa 18,600 BP) represented by only a few occupation sites in western Central Europe. A number of human remains at Magdalenian sites appear to result from variable (secondary) burial practices. In contrast, the Final Paleolithic (circa 12,000-9600 cal. BC) yields an increase of hominin finds, including multiple burials (Bonn-Oberkassel, Neuwied-Irlich), similar to the situation in western and southern Europe.

Streamflow Measurements in North-Central Nebraska, November 2006

USGS Publications Warehouse

Peterson, Steven M.; Strauch, Kellan R.

2007-01-01

Streamflow measurements were made during November of 2006 in the Elkhorn and Loup River basins and selected streams in the Niobrara and Platte River basins in north-central Nebraska. At these 531 sites, flows ranging from no flow to 2,600 ft3/s were measured or observed. The data are presented in a table along with the quality of measurement and the method that was used. Maps show the location of the study area and the sites.

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe discusses the presentation about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Florida Congressman Tom Feeney, Congressman Dave Weldon, U.S. Representative Ric Keller, U.S. Senator Bill Nelson, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - NASA Administrator Sean O’Keefe discusses the presentation about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Florida Congressman Tom Feeney, Congressman Dave Weldon, U.S. Representative Ric Keller, U.S. Senator Bill Nelson, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

KENNEDY SPACE CENTER, FLA. - U.S. Senator Bill Nelson (center) makes a point while talking to NASA Administrator Sean O’Keefe (right) about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Congressman Tom Feeney, Congressman Dave Weldon, U.S. Representative Ric Keller, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

NASA Image and Video Library

2004-02-19

KENNEDY SPACE CENTER, FLA. - U.S. Senator Bill Nelson (center) makes a point while talking to NASA Administrator Sean O’Keefe (right) about the assets of the Central Florida Research Park, near Orlando, as the site of NASA’s new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASA’s payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Congressman Tom Feeney, Congressman Dave Weldon, U.S. Representative Ric Keller, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

21 CFR 1305.24 - Central processing of orders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates. ...

Help Central: Creating a Help Desk and Knowledge Portal in SharePoint

ERIC Educational Resources Information Center

Ennis, Lisa A.; Tims, Randy S.

2012-01-01

This article discusses the authors' implementation of Help Central, a site within the Lister Hill Library Collection on the University of Alabama-Birmingham's SharePoint server. Initially, Help Central was designed to address the inadequacies in the library's old, static HTML web-based support system, including haphazard issue reporting by staff…

Global convergence in the temperature sensitivity of respiration at ecosystem level.

PubMed

Mahecha, Miguel D; Reichstein, Markus; Carvalhais, Nuno; Lasslop, Gitta; Lange, Holger; Seneviratne, Sonia I; Vargas, Rodrigo; Ammann, Christof; Arain, M Altaf; Cescatti, Alessandro; Janssens, Ivan A; Migliavacca, Mirco; Montagnani, Leonardo; Richardson, Andrew D

2010-08-13

The respiratory release of carbon dioxide (CO(2)) from the land surface is a major flux in the global carbon cycle, antipodal to photosynthetic CO(2) uptake. Understanding the sensitivity of respiratory processes to temperature is central for quantifying the climate-carbon cycle feedback. We approximated the sensitivity of terrestrial ecosystem respiration to air temperature (Q(10)) across 60 FLUXNET sites with the use of a methodology that circumvents confounding effects. Contrary to previous findings, our results suggest that Q(10) is independent of mean annual temperature, does not differ among biomes, and is confined to values around 1.4 +/- 0.1. The strong relation between photosynthesis and respiration, by contrast, is highly variable among sites. The results may partly explain a less pronounced climate-carbon cycle feedback than suggested by current carbon cycle climate models.

A clinical case-based hypothesis: secretory IgA operates as an electronic transistor controlling the selection or rejection of molecules in the absorption process in the lumen of gastrointestinal tract

PubMed Central

Zamm, Alfred V

2013-01-01

There is a clinical correlation between (1) an allergic patient’s ability to resist the development of symptoms that would have resulted from an allergenic challenge, (2) the magnitude of geomagnetism at a geographic site, and (3) the amount of solar energy falling on that site. It is suggested that the digestive membrane has an electronic gatekeeper that “decides” electronically which molecules to allow or not allow to pass on to the absorptive surface. The unique bipolar structure of secretory immunoglobulin A (IgA), having a central secretory piece and the resultant unique electronic function of this polarized molecule, allows it to function as an electronic transistor, producing an electronic gatekeeper in the form of an electronic sieve. PMID:24068871

A clinical case-based hypothesis: secretory IgA operates as an electronic transistor controlling the selection or rejection of molecules in the absorption process in the lumen of gastrointestinal tract.

PubMed

Zamm, Alfred V

2013-01-01

There is a clinical correlation between (1) an allergic patient's ability to resist the development of symptoms that would have resulted from an allergenic challenge, (2) the magnitude of geomagnetism at a geographic site, and (3) the amount of solar energy falling on that site. It is suggested that the digestive membrane has an electronic gatekeeper that "decides" electronically which molecules to allow or not allow to pass on to the absorptive surface. The unique bipolar structure of secretory immunoglobulin A (IgA), having a central secretory piece and the resultant unique electronic function of this polarized molecule, allows it to function as an electronic transistor, producing an electronic gatekeeper in the form of an electronic sieve.

Assessment of possible airborne impact from nuclear risk sites - Part II: probabilistic analysis of atmospheric transport patterns in Euro-Arctic region

NASA Astrophysics Data System (ADS)

Mahura, A. G.; Baklanov, A. A.

2003-10-01

The probabilistic analysis of atmospheric transport patterns from most important nuclear risk sites in the Euro-Arctic region is performed employing the methodology developed within the "Arctic Risk" Project of the NARP Programme (Baklanov and Mahura, 2003). The risk sites are the nuclear power plants in the Northwest Russia, Finland, Sweden, Lithuania, United Kingdom, and Germany as well as the Novaya Zemlya test site of Russia. The geographical regions of interest are the Northern and Central European countries and Northwest Russia. In this study, the employed research tools are the trajectory model to calculate a multiyear dataset of forward trajectories that originated over the risk site locations, and a set of statistical methods (including exploratory, cluster, and probability fields analyses) for analysis of trajectory modelling results. The probabilistic analyses of trajectory modelling results for eleven sites are presented as a set of various indicators of the risk sites possible impact on geographical regions and countries of interest. The nuclear risk site possible impact (on a particular geographical region, territory, country, site, etc.) due to atmospheric transport from the site after hypothetical accidental release of radioactivity can be properly estimated based on a combined interpretation of the indicators (simple characteristics, atmospheric transport pathways, airflow and fast transport probability fields, maximum reaching distance and maximum possible impact zone, typical transport time and precipitation factor fields) for different time periods (annual, seasonal, and monthly) for any selected site (both separately for each site or grouped for several sites) in the Euro-Arctic region. Such estimation could be the useful input information for the decision-making process, risk assessment, and planning of emergency response systems for sites of nuclear, chemical, and biological danger.

Baroreflex regulation of blood pressure during dynamic exercise

NASA Technical Reports Server (NTRS)

Raven, P. B.; Potts, J. T.; Shi, X.; Blomqvist, C. G. (Principal Investigator)

1997-01-01

From the work of Potts et al. Papelier et al. and Shi et al. it is readily apparent that the arterial (aortic and carotid) baroreflexes are reset to function at the prevailing ABP of exercise. The blood pressure of exercise is the result of the hemodynamic (cardiac output and TPR) responses, which appear to be regulated by two redundant neural control systems, "Central Command" and the "exercise pressor reflex". Central Command is a feed-forward neural control system that operates in parallel with the neural regulation of the locomotor system and appears to establish the hemodynamic response to exercise. Within the central nervous system it appears that the HLR may be the operational site for Central Command. Specific neural sites within the HLR have been demonstrated in animals to be active during exercise. With the advent of positron emission tomography (PET) and single-photon emission computed tomography (SPECT), the anatomical areas of the human brain related to Central Command are being mapped. It also appears that the Nucleus Tractus Solitarius and the ventrolateral medulla may serve as an integrating site as they receive neural information from the working muscles via the group III/IV muscle afferents as well as from higher brain centers. This anatomical site within the CNS is now the focus of many investigations in which arterial baroreflex function, Central Command and the "exercise pressor reflex" appear to demonstrate inhibitory or facilitatory interaction. The concept of whether Central Command is the prime mover in the resetting of the arterial baroreceptors to function at the exercising ABP or whether the resetting is an integration of the "exercise pressor reflex" information with that of Central Command is now under intense investigation. However, it would be justified to conclude, from the data of Bevegard and Shepherd, Dicarlo and Bishop, Potts et al., and Papelier et al. that the act of exercise results in the resetting of the arterial baroreflex. In addition, if, as we have proposed, the cardiopulmonary baroreceptors primarily monitors and reflexly regulates cardiac filling volume, it would seem from the data of Mack et al. and Potts et al. that the cardiopulmonary baroreceptor is also reset at the beginning of exercise. Therefore, investigations of the neural mechanisms of regulation involving Central Command and cardiopulmonary afferents, similar to those being undertaken for the arterial baroreflex, need to be established.

Nutrient dynamics across a dissolved organic carbon and burn gradient in central Siberia

NASA Astrophysics Data System (ADS)

Rodriguez-Cardona, B.; Coble, A. A.; Prokishkin, A. S.; Kolosov, R.; Spencer, R. G.; Wymore, A.; McDowell, W. H.

2016-12-01

In stream ecosystems, dissolved organic carbon (DOC) and nitrogen (N) processing are tightly linked. In temperate streams, greater DOC concentrations and higher DOC:NO3- ratios promote the greatest nitrate (NO3-) uptake. However, less is known about this relationship in other biomes including the arctic which is undergoing changes due to climate change contributing to thawing of permafrost and alterations in biogeochemical cycles in soils and streams. Headwater streams draining into the N. Tunguska River in the central Siberian plateau are affected by forest fires but little is known about the aquatic biogeochemical implications in both a thawing and burning landscape. There are clear patterns between carbon concentration and fire history where generally DOC concentration in streams decrease after fires and older burn sites have shown greater DOC concentrations and more bioavailable DOC that could promote greater heterotrophic uptake of NO3-. However, the relationship between nutrient dynamics, organic matter composition, and fire history in streams is not very clear. In order to assess the influence of organic matter composition and DOC concentration on nutrient uptake in arctic streams, we conducted a series of short-term nutrient addition experiments following the tracer addition for spiraling curve characterization (TASCC) method, consisting of NO3- and NH4++PO43- additions, across 4 streams that comprise a fire gradient that spans 3- >100 years since the last burn with DOC concentrations ranging between 12-23 mg C/L. We hypothesized that nutrient uptake would be greatest in older burn sites due to greater DOC concentrations and availability. We will specifically examine how nutrient uptake relates to DOC concentration and OM composition (analyzed via FTICR-MS) across the burn gradient. Across the four sites DOC concentration and DOC:NO3- ratios decreased from old burn sites to recently burned sites. Results presented here can elucidate on the potential impacts of permafrost thawing and forest fires on nutrient dynamics in arctic streams.

"out of The Cold": On Late Neanderthal Population Dynamics In Central Europe

NASA Astrophysics Data System (ADS)

Jöris, O.

During the last several years, analyses of fossil Neanderthal DNA have shown not only the degree to which the genetic fingerprints of Neanderthals differ from those of anatomically modern humans, but have also lent credibility to the hotly debated "Out- of-Africa" hypothesis. Perhaps more important than the observed genetic differences is the fact that Neanderthals - according to their reconstructed DNA sequences - were genetically highly homogeneous, indicating rapid population growth that may have followed a demographic 'bottleneck' during the first cold maximum (CM-1 = second part of OIS 4) of the last glacial, some 60 to 70 ka ago. Central European Middle Palaeolithic sites characterised by broad spectra of bifacially-worked tools, namely different forms of backed knives ("Keilmesser") com- monly attributed to Neanderthals, fall within the age-range 85 and 45 ka calBP and thus both pre- and post-date the proposed 'bottleneck' that occurred during CM-1. Di- rectly comparable sites dating within this critical period are lacking. Based on strati- graphic, palaeoenvironmental, and radiometric evidence, a series of sites can tenta- tively be age-calibrated with the high-resolution GISP2 Greenland ice core record of last glacial climate change. With the aid of improved chronological frameworks and additional palaeoenvironmen- tal information (e.g. glacier mass balance models), we have developed a three-step model with which to investigate this period. We begin with (1) pre-CM-1 populations in Central and northern Central Europe which (2) were forced into southern Euro- pean refugia (i.e. SW France and the Pannonian Basins) by the rapid expansion of the northern hemispheric ice-cover at the beginning of CM-1 (a process that could be named 'preglacial dislocation'). Finally, some 10 ka later, their descendants may have re-occupied the southern part of Central Europe during the climatic amelioration (OIS 3) following CM-1. Changes in lithic technology, as expressed in extremely in- tensive resharpening and curation of the bifacial tools, may reflect the higher mobility of groups moving south within step (2) of the outlined model. Today, most scholars interpret some characteristic features in late Neanderthal mor- phology as a result of adaptation to cold environmental conditions that existed over vast areas of Europe. It is striking that these (morphologically) typical or 'classical' Neanderthals appear in Europe for the first time quite suddenly during OIS 4. This 1 observation seems to lend support to the North-to-South shifts of past populations dur- ing the period under discussion. Due to poor site preservation, as well as the complete lack of northern European sites from the 'Lost North' area covered by the ice-shields of the last cold maxima, discussions of population movements in this direction have been largely omitted from past models concerning the Middle to Upper Palaeolithic transition. In order to understand the disappearance of Neanderthals, future research must syn- chronize information from palaeoenvironmental and palaeoclimate datasets with the chronological framework appropriate to the archaeological sites being investigated. It is also critical that archaeological models be reassessed, as these frameworks are continually being refined. The disappearance of Neanderthal morphological features approximately 30 - 40 ka ago can serve as a key to understanding modern human origins. Unfortunately, researchers do not yet understand the mechanisms governing genetic inheritance, and thus it is not yet possible to distinguish between biological species and morphological ones. As a consequence, it remains unclear whether Nean- derthal morphological features disappeared as populations evolved toward the modern form, or if Neanderthals were actually replaced by Modern Humans. 2

Moving a randomized clinical trial into an observational cohort.

PubMed

Goodman, Phyllis J; Hartline, Jo Ann; Tangen, Catherine M; Crowley, John J; Minasian, Lori M; Klein, Eric A; Cook, Elise D; Darke, Amy K; Arnold, Kathryn B; Anderson, Karen; Yee, Monica; Meyskens, Frank L; Baker, Laurence H

2013-02-01

The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double-blind, placebo-controlled prostate cancer prevention study funded by the National Cancer Institute (NCI) and conducted by the Southwest Oncology Group (SWOG). A total of 35,533 men were assigned randomly to one of the four treatment groups (vitamin E + placebo, selenium + placebo, vitamin E + selenium, and placebo + placebo). The independent Data and Safety Monitoring Committee (DSMC) recommended the discontinuation of study supplements because of the lack of efficacy for risk reduction and because futility analyses demonstrated no possibility of benefit of the supplements to the anticipated degree (25% reduction in prostate cancer incidence) with additional follow-up. Study leadership agreed that the randomized trial should be terminated but believed that the cohort should be maintained and followed as the additional follow-up would contribute important information to the understanding of the biologic consequences of the intervention. Since the participants no longer needed to be seen in person to assess acute toxicities or to be given study supplements, it was determined that the most efficient and cost-effective way to follow them was via a central coordinated effort. A number of changes were necessary at the local Study Sites and SELECT Statistical Center to transition to following participants via a Central Coordinating Center. We describe the transition process from a randomized clinical trial to the observational Centralized Follow-Up (CFU) study. The process of transitioning SELECT, implemented at more than 400 Study Sites across the United States, Canada, and Puerto Rico, entailed many critical decisions and actions including updates to online documents such as the SELECT Workbench and Study Manual, a protocol amendment, reorganization of the Statistical Center, creation of a Transition Committee, development of materials for SELECT Study Sites, development of procedures to close Study Sites, and revision of data collection procedures and the process by which to contact participants. At the time of the publication of the primary SELECT results in December 2008, there were 32,569 men alive and currently active in the trial. As of 31 December 2011, 17,761 participants had been registered to the CFU study. This number is less than had been anticipated due to unforeseen difficulties with local Study Site institutional review boards (IRBs). However, from this cohort, we estimate that an additional 580 prostate cancer cases and 215 Gleason 7 or higher grade cancers will be identified. Over 109,000 individual items have been mailed to participants. Active SELECT ancillary studies have continued. The substantial SELECT biorepository is available to researchers; requests to use the specimens are reviewed for feasibility and scientific merit. As of April 2012, 12 proposals had been approved. The accrual goal of the follow-up study was not met, limiting our power to address the study objectives satisfactorily. The CFU study is also dependent on a number of factors including continued funding, continued interest of investigators in the biorepository, and the continued contribution of the participants. Our experience may be less pertinent to investigators who wish to follow participants in a treatment trial or participants in prevention trials in other medical areas. Extended follow-up of participants in prevention research is important to study the long-term effects of the interventions, such as those used in SELECT. The approach taken by SELECT investigators was to continue to follow participants centrally via an annual questionnaire and with a web-based option. The participants enrolled in the CFU study represent a large, well-characterized, generally healthy cohort. The CFU has enabled us to collect additional prostate and other cancer endpoints and longer follow-up on the almost 18,000 participants enrolled. The utility of the extensive biorepository that was developed during the course of the SELECT is enhanced by longer follow-up.

Moving a Randomized Clinical Trial into an Observational Cohort

PubMed Central

Goodman, Phyllis J.; Hartline, Jo Ann; Tangen, Catherine M.; Crowley, John J.; Minasian, Lori M.; Klein, Eric A.; Cook, Elise D.; Darke, Amy K.; Arnold, Kathryn B.; Anderson, Karen; Yee, Monica; Meyskens, Frank L.; Baker, Laurence H.

2013-01-01

Background The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double blind, placebo-controlled prostate cancer prevention study funded by the National Cancer Institute and conducted by SWOG (Southwest Oncology Group). A total of 35,533 men were assigned randomly to one of four treatment groups (vitamin E + placebo, selenium + placebo, vitamin E + selenium, placebo + placebo. The independent Data and Safety Monitoring Committee recommended the discontinuation of study supplements because of the lack of efficacy for risk reduction and because futility analyses demonstrated no possibility of benefit of the supplements to the anticipated degree (25% reduction in prostate cancer incidence) with additional follow-up. Study leadership agreed that the randomized trial should be terminated but believed that the cohort should be maintained and followed as the additional follow-up would contribute important information to the understanding of the biologic consequences of the intervention. Since the participants no longer needed to be seen in person to assess acute toxicities or to be given study supplements, it was determined that the most efficient and cost-effective way to follow them was via a central coordinated effort. Purpose A number of changes were necessary at the local Study Sites and SELECT Statistical Center to transition to following participants via a Central Coordinating Center. We describe the transition process from a randomized clinical trial to the observational Centralized Follow-up (CFU) study. Methods The process of transitioning SELECT, implemented at more than 400 Study Sites across the United States, Canada and Puerto Rico, entailed many critical decisions and actions including updates to online documents such as the SELECT Workbench and Study Manual, a protocol amendment, reorganization of the Statistical Center, creation of a Transition Committee, development of materials for SELECT Study Sites, development of procedures to close Study Sites, and revision of data collection procedures and the process by which to contact participants. Results At the time of the publication of the primary SELECT results in December 2008, there were 32,569 men alive and currently active in the trial. As of December 31, 2011, 17,761 participants had been registered to the CFU study. This number is less than had been anticipated due to unforeseen difficulties with local Study Site IRBs. However, from this cohort we estimate that an additional 580 prostate cancer cases and 215 Gleason 7 or higher cancers will be identified. Over 109,000 individual items have been mailed to participants. Active SELECT ancillary studies have continued. The substantial SELECT biorepository is available to researchers; requests to use the specimens are reviewed for feasibility and scientific merit. As of April 2012, 12 proposals had been approved. Limitations The accrual goal of the follow-up study was not met, limiting our power to address the study objectives satisfactorily. The CFU study is also dependent on a number of factors including continued funding, continued interest of investigators in the biorepository and the continued contribution of the participants. Our experience may be less pertinent to investigators who wish to follow participants in a treatment trial or participants in prevention trials in other medical areas. Conclusions Extended follow-up of participants in prevention research is important to study the long-term effects of the interventions, such as those used in SELECT. The approach taken by SELECT investigators was to continue to follow participants centrally via an annual questionnaire and with a web-based option. The participants enrolled in the CFU study represent a large, well-characterized, generally healthy cohort. The CFU has enabled us to collect additional prostate and other cancer endpoints and longer follow-up on the almost 18,000 participants enrolled. The utility of the extensive biorepository that was developed during the course of the SELECT is enhanced by longer follow-up. PMID:23064404

Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters.

PubMed

Dettenkofer, M; Jonas, D; Wiechmann, C; Rossner, R; Frank, U; Zentner, J; Daschner, F D

2002-10-01

We investigated the efficacy of two commercially available, alcohol-based antiseptic solutions in decontaminating the insertion site of central lines. One solution contained the bispyridine octenidine dihydrochloride. Inpatients receiving either a central venous catheter (CVC) or a peripherally inserted central catheter (PICC) were alternately assigned to different skin disinfection regimens at the insertion site: (A) 0.1% octendine dihydrochloride with 30% 1-propanol and 45% 2-propanol, (B) 74% ethanol with 10% 2-propanol. Quantitative skin cultures were obtained from the insertion site at predetermined intervals. A total of 60 patients received 12 CVCs and 47 PICCs (no significant difference with respect to gender, age and catheter type). In total, 90 cultures were assessed in each group. The median colony-forming unit (cfu) counts per 24 cm(2) (group A vs B) were 2,270 vs 2,950 before, 20 vs 40 following and 860 vs 1,210 24 h after catheter insertion, respectively. A statistically significant difference in the efficacy of skin decontamination was seen between groups in culture set (3) and in the difference between culture sets (2) and (3) (Wilcoxon rank sum test). Octenidine/propanol appears to be more effective than alcohol (ethanol/propanol) alone in reducing microflora of the skin at the PICC/CVC insertion site over a 24-h period.

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodder, Anthony N.; Malby, Robyn L.; Clarke, Oliver B.

The sera genes of the malaria-causing parasite Plasmodium encode a family of unique proteins that are maximally expressed at the time of egress of parasites from infected red blood cells. These multi-domain proteins are unique, containing a central papain-like cysteine-protease fragment enclosed between the disulfide-linked N- and C-terminal domains. However, the central fragment of several members of this family, including serine repeat antigen 5 (SERA5), contains a serine (S596) in place of the active-site cysteine. Here we report the crystal structure of the central protease-like domain of Plasmodium falciparum SERA5, revealing a number of anomalies in addition to the putativemore » nucleophilic serine: (1) the structure of the putative active site is not conducive to binding substrate in the canonical cysteine-protease manner; (2) the side chain of D594 restricts access of substrate to the putative active site; and (3) the S{sub 2} specificity pocket is occupied by the side chain of Y735, reducing this site to a small depression on the protein surface. Attempts to determine the structure in complex with known inhibitors were not successful. Thus, despite having revealed its structure, the function of the catalytic domain of SERA5 remains an enigma.« less

SITE TECHNOLOGY CAPSULE: ROCHEM SEPARATION SYSTEMS, INC. - DISC TUBE MODULE TECHNOLOGY

EPA Science Inventory

SITE Program demonstration of the Rochem Disc Tube Module™(DTM) developed by Rochem Separations Systems, Inc. The demonstration test was conducted at the central landfill superfund site in Johnston, Rhode island in August, 1994. The DTM technology is an innovative membrane filt...

The conservation of the Shahr-e-Zohak archaeological site (central Afghanistan): Geomorphological processes and ecosystem-based mitigation

NASA Astrophysics Data System (ADS)

Margottini, Claudio; Fidolini, Francesco; Iadanza, Carla; Trigila, Alessandro; Ubelmann, Yves

2015-06-01

The archaeological remains of Shahr-e Zohak are part of the Bamiyan valley, which has been recognized by UNESCO as World Heritage and is famous for hosting the main heritage of the Buddhist culture in Afghanistan. The site comprises the remains of the Zohak fortress, which is placed on a steep hill at the confluence of the Bamiyan and Kalu rivers. The fortress is protected by ramparts, built along the steep cliffs bounding the site, which are equipped with several watchtowers. The citadel is protected by three more orders of walls and is located on the topmost part of the hill. All the structures are made of mudbricks placed on top of stony foundations. Due to the prolonged exposure to weathering, the lack of conservation measures and the misuse during war periods, many constructions collapsed or are prone to collapse. A new topography (1 m contour lines) of the site was produced using drone-derived 3D photogrammetry combined with GPS data. Then a detailed geomorphological survey of the whole site was carried out in order to identify the main geomorphic processes acting on the land surface and structures. GIS analysis allowed defining the internal drainage system of the studied area. The site is affected by incised erosional phenomena on the eastern side, while the hilltop is mainly hit by diffuse erosion and soil mobilization during snowmelt. Monument deterioration is coupled with the lack of an adequate drainage system to collect runoff. Ramparts located on the steep hillslopes are severely affected by gully erosion and siphoning, which cause depressions infilled by eroded and weathered building material. The access path is locally eroded or buried by debris cones. The western margin of the plateau has been rapidly retreating due to collapses, while the citadel is in danger due to diffuse or gully erosional processes developed on all its sides. A mitigation strategy with low environmental impact (ecosystem-based approach) is proposed in order to adopt sustainable, systemic and cost-effective tools for soil conservation, in order to improve the environmental resilience of the site.

KSC-04PD-0256

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. NASA officials and government representatives are gathered to learn about the assets of the Central Florida Research Park, near Orlando. At the far end of the table is NASA Administrator Sean OKeefe. He is flanked, on the left, by Florida Congressman Tom Feeney and U.S. Senator Bill Nelson; and on the right by U.S. Congressman Dave Weldon. Central Florida leaders are proposing the research park as the site for the NASA Shared Services Center. The center would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Six sites around the U.S. are under consideration by NASA.

The creative brain in the figural domain: Distinct patterns of EEG alpha power during idea generation and idea elaboration.

PubMed

Rominger, Christian; Papousek, Ilona; Perchtold, Corinna M; Weber, Bernhard; Weiss, Elisabeth M; Fink, Andreas

2018-02-13

This study investigated EEG activity in the upper alpha band during the well-known Picture Completion Task of the Torrance Test of Creative Thinking (TTCT), a widely used creative ideation task in the figural domain. The application of a sophisticated computerized version of the TTCT facilitating the online assessment and digitalizing of participant's drawings allowed to separate two central stages of the creative ideation process (i.e., idea generation and idea elaboration). During idea generation, the participants' task was to generate an initial draft of an original and creative completion of the presented abstract lines and figures of the TTCT. During idea elaboration, the participants were required to mentally improve the originality of the initially generated idea/draft. Creative ideation in this figural task was generally associated with comparatively strong desynchronization of upper alpha power over parietal and occipital sites, indicating high visual/figural processing demands. Interestingly, the stage of idea elaboration was accompanied by a relative increase of upper alpha power at parietal and occipital sites compared to the stage of idea generation, indicating heightened top-down processing demands. Furthermore, task performance was associated with relative increases of upper alpha power at frontal sites and relative decreases at centro-temporal sites from the stage of idea generation to idea elaboration. This association suggests the importance of increased inhibitory control over stimulus-based bottom-up information and motor imagery in order to achieve more creative outputs. Taken together these findings add to the relevant literature in that they a) extend research on the relationship between EEG alpha activity and creativity to the figural domain, and b) support a multistage view of creative ideation, involving cognitive control and mental imagery as important components of creativity. Copyright © 2018 Elsevier Ltd. All rights reserved.

The influence of (central) auditory processing disorder on the severity of speech-sound disorders in children.

PubMed

Vilela, Nadia; Barrozo, Tatiane Faria; Pagan-Neves, Luciana de Oliveira; Sanches, Seisse Gabriela Gandolfi; Wertzner, Haydée Fiszbein; Carvallo, Renata Mota Mamede

2016-02-01

To identify a cutoff value based on the Percentage of Consonants Correct-Revised index that could indicate the likelihood of a child with a speech-sound disorder also having a (central) auditory processing disorder . Language, audiological and (central) auditory processing evaluations were administered. The participants were 27 subjects with speech-sound disorders aged 7 to 10 years and 11 months who were divided into two different groups according to their (central) auditory processing evaluation results. When a (central) auditory processing disorder was present in association with a speech disorder, the children tended to have lower scores on phonological assessments. A greater severity of speech disorder was related to a greater probability of the child having a (central) auditory processing disorder. The use of a cutoff value for the Percentage of Consonants Correct-Revised index successfully distinguished between children with and without a (central) auditory processing disorder. The severity of speech-sound disorder in children was influenced by the presence of (central) auditory processing disorder. The attempt to identify a cutoff value based on a severity index was successful.

Event-related potential correlates of paranormal ideation and unusual experiences.

PubMed

Sumich, Alex; Kumari, Veena; Gordon, Evian; Tunstall, Nigel; Brammer, Michael

2008-01-01

Separate dimensions of schizotypy have been differentially associated with electrophysiological measures of brain function, and further shown to be modified by sex/gender. We investigated event-related potential (ERP) correlates of two subdimensions of positive schizotypy, paranormal ideation (PI) and unusual experiences (UEs). Seventy-two individuals with no psychiatric diagnosis (men=36) completed self-report measures of UE and PI and performed an auditory oddball task. Average scores for N100, N200 and P300 amplitudes were calculated for left and right anterior, central and posterior electrode sites. Multiple linear regression was used to examine the relationships between the measures of schizotypy and ERPs across the entire sample, as well as separately according to sex. PI was inversely associated with P300 amplitude at left-central sites across the entire sample, and at right-anterior electrodes in women only. Right-anterior P300 and right-posterior N100 amplitudes were negatively associated with UE in women only. Across the entire sample, UE was negatively associated with left-central N100 amplitude, and positively associated with left-anterior N200 amplitude. These results provide support from electrophysiological measures for the fractionation of the positive dimension of schizotypy into subdimensions of PI and UE, and lend indirect support to dimensional or quasidimensional conceptions of psychosis. More specifically, they suggest that PI may be associated with alteration in contextual updating processes, and that UE may reflect altered sensory/early-attention (N100) mechanisms. The sex differences observed are consistent with those previously observed in individuals with schizophrenia.

Future U.S. supply of Mo-99 production through fission based LEU/LEU technology.

PubMed

Welsh, James; Bigles, Carmen I; Valderrabano, Alejandro

Coquí RadioPharmaceuticals Corp. (Coquí) has the goal of establishing a medical isotope production facility for securing a continuous domestic supply of the radioisotope molybdenum-99 for U.S. citizens. Coquí will use an LEU/LEU proven and implemented open pool, light-water, 10 MW, reactor design. The facility is being designed with twin reactors for reliability an on-site hot lab chemical processing and a waste conditioning area and a possible generator producing radio-chemistry lab. Coquí identified a 25 acre site adjacent to an existing industrial park in northern central Florida. This land was gifted and transferred to Coquí by the University of Florida Foundation. We are in the process of developing licensing documents related to the facility. The construction permit application for submission to the U.S. Nuclear Regulatory Commission is currently being prepared. Submission is scheduled for mid to late 2015. Community reaction to the proposed development has been positive. We expect to create 220 permanent jobs and we have an anticipated to be operational by 2020.

Van Allen Probes Science Gateway and Space Weather Data Processing

NASA Astrophysics Data System (ADS)

Romeo, G.; Barnes, R. J.; Weiss, M.; Fox, N. J.; Mauk, B.; Potter, M.; Kessel, R.

2014-12-01

The Van Allen Probes Science Gateway acts as a centralized interface to the instrument Science Operation Centers (SOCs), provides mission planning tools, and hosts a number of science related activities such as the mission bibliography. Most importantly, the Gateway acts as the primary site for processing and delivering the VAP Space Weather data to users. Over the past year, the web-site has been completely redesigned with the focus on easier navigation and improvements of the existing tools such as the orbit plotter, position calculator and magnetic footprint tool. In addition, a new data plotting facility has been added. Based on HTML5, which allows users to interactively plot Van Allen Probes summary and space weather data. The user can tailor the tool to display exactly the plot they wish to see and then share this with other users via either a URL or by QR code. Various types of plots can be created, including simple time series, data plotted as a function of orbital location, and time versus L-Shell. We discuss the new Van Allen Probes Science Gateway and the Space Weather Data Pipeline.

Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies

PubMed Central

Pandya, Anshul. A.; Yakel, Jerrel L.

2013-01-01

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation-conducting transmembrane channels from the cys-loop receptor superfamily. The neuronal subtypes of these receptors (e.g. the α7 and α4β2 subtypes) are involved in neurobehavioral processes such as anxiety, the central processing of pain, food intake, nicotine seeking behavior, and a number of cognitive functions like learning and memory. Neuronal nAChR dysfunction is involved in the pathophysiology of many neurological disorders, and behavioral studies in animals are useful models to assess the effects of compounds that act on these receptors. Allosteric modulators are ligands that bind to the receptors at sites other than the orthosteric site where acetylcholine, the endogenous agonist for the nAChRs, binds. While conventional ligands for the neuronal nAChRs have been studied for their behavioral effects in animals, allosteric modulators for these receptors have only recently gained attention, and research on their behavioral effects is growing rapidly. Here we will discuss the behavioral effects of allosteric modulators of the neuronal nAChRs. PMID:23732296

Radioactive waste management treatments: A selection for the Italian scenario

DOE Office of Scientific and Technical Information (OSTI.GOV)

Locatelli, G.; Mancini, M.; Sardini, M.

2012-07-01

The increased attention for radioactive waste management is one of the most peculiar aspects of the nuclear sector considering both reactors and not power sources. The aim of this paper is to present the state-of-art of treatments for radioactive waste management all over the world in order to derive guidelines for the radioactive waste management in the Italian scenario. Starting with an overview on the international situation, it analyses the different sources, amounts, treatments, social and economic impacts looking at countries with different industrial backgrounds, energetic policies, geography and population. It lists all these treatments and selects the most reasonablemore » according to technical, economic and social criteria. In particular, a double scenario is discussed (to be considered in case of few quantities of nuclear waste): the use of regional, centralized, off site processing facilities, which accept waste from many nuclear plants, and the use of mobile systems, which can be transported among multiple nuclear sites for processing campaigns. At the end the treatments suitable for the Italian scenario are presented providing simplified work-flows and guidelines. (authors)« less

Dissociation between morality and disgust: an event-related potential study.

PubMed

Yang, Qun; Li, An; Xiao, Xiao; Zhang, Ye; Tian, Xuehong

2014-10-01

This study explored the neural correlates of morality and disgust, particularly, how the mechanisms that mediate our avoidance of physically disgusting and morally abhorrent behaviors are neurologically dissociated during the time-course of processing. Twelve participants were asked to judge the acceptability of different types of behaviors, which varied in their level of moral wrongness and physical disgust, while event-related potentials (ERPs) were recorded. The main results showed that the two morally wrong conditions elicited greater amplitudes of P300-400 at frontal sites than the neutral condition and the physically disgusting, but not morally wrong, condition. The physically disgusting conditions (with and without moral content) elicited significantly more positive deflections in the 500-600 ms timeframe than the neutral condition at central-posterior sites. These findings indicate that our aversion to harmful substances in the physical environment and offensive behaviors in the social environment may be neurologically dissociable in the temporal dimension. Furthermore, the detection of moral violations may be processed earlier in time than that of physical disgust. Copyright © 2014 Elsevier B.V. All rights reserved.

Floristic diversity, stand structure, and composition 11 years after herbicide site preparation

Treesearch

James H. Miller; Robert S. Boyd; M. Boyd Edwards

1999-01-01

This study tested for effects of site preparation herbicides applied at high labeled rates 11 years earlier on plant species richness, diversity, and stand structure and composition. Four study sites in three physiographic provinces were established in central Georgia in 1984. Six herbicide treatments were included on each site: hexazinone liquid, hexazinone pellets,...

Response of the Pacific inter-tropical convergence zone to global cooling and initiation of Antarctic glaciation across the Eocene Oligocene Transition

PubMed Central

Hyeong, Kiseong; Kuroda, Junichiro; Seo, Inah; Wilson, Paul A.

2016-01-01

Approximately 34 million years ago across the Eocene–Oligocene transition (EOT), Earth’s climate tipped from a largely unglaciated state into one that sustained large ice sheets on Antarctica. Antarctic glaciation is attributed to a threshold response to slow decline in atmospheric CO2 but our understanding of the feedback processes triggered and of climate change on the other contents is limited. Here we present new geochemical records of terrigenous dust accumulating on the sea floor across the EOT from a site in the central equatorial Pacific. We report a change in dust chemistry from an Asian affinity to a Central-South American provenance that occurs geologically synchronously with the initiation of stepwise global cooling, glaciation of Antarctica and aridification on the northern continents. We infer that the inter-tropical convergence zone of intense precipitation extended to our site during late Eocene, at least four degrees latitude further south than today, but that it migrated northwards in step with global cooling and initiation of Antarctic glaciation. Our findings point to an atmospheric teleconnection between extratropical cooling and rainfall climate in the tropics and the mid-latitude belt of the westerlies operating across the most pivotal transition in climate state of the Cenozoic Era. PMID:27507793

Response of the Pacific inter-tropical convergence zone to global cooling and initiation of Antarctic glaciation across the Eocene Oligocene Transition

NASA Astrophysics Data System (ADS)

Hyeong, Kiseong; Kuroda, Junichiro; Seo, Inah; Wilson, Paul A.

2016-08-01

Approximately 34 million years ago across the Eocene-Oligocene transition (EOT), Earth’s climate tipped from a largely unglaciated state into one that sustained large ice sheets on Antarctica. Antarctic glaciation is attributed to a threshold response to slow decline in atmospheric CO2 but our understanding of the feedback processes triggered and of climate change on the other contents is limited. Here we present new geochemical records of terrigenous dust accumulating on the sea floor across the EOT from a site in the central equatorial Pacific. We report a change in dust chemistry from an Asian affinity to a Central-South American provenance that occurs geologically synchronously with the initiation of stepwise global cooling, glaciation of Antarctica and aridification on the northern continents. We infer that the inter-tropical convergence zone of intense precipitation extended to our site during late Eocene, at least four degrees latitude further south than today, but that it migrated northwards in step with global cooling and initiation of Antarctic glaciation. Our findings point to an atmospheric teleconnection between extratropical cooling and rainfall climate in the tropics and the mid-latitude belt of the westerlies operating across the most pivotal transition in climate state of the Cenozoic Era.

Does Quality of Radiation Therapy Predict Outcomes of Multicenter Cooperative Group Trials? A Literature Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fairchild, Alysa, E-mail: alysa.fairchild@albertahealthservices.ca; Straube, William; Laurie, Fran

2013-10-01

Central review of radiation therapy (RT) delivery within multicenter clinical trials was initiated in the early 1970s in the United States. Early quality assurance publications often focused on metrics related to process, logistics, and timing. Our objective was to review the available evidence supporting correlation of RT quality with clinical outcomes within cooperative group trials. A MEDLINE search was performed to identify multicenter studies that described central subjective assessment of RT protocol compliance (quality). Data abstracted included method of central review, definition of deviations, and clinical outcomes. Seventeen multicenter studies (1980-2012) were identified, plus one Patterns of Care Study. Diseasemore » sites were hematologic, head and neck, lung, breast, and pancreas. Between 0 and 97% of treatment plans received an overall grade of acceptable. In 7 trials, failure rates were significantly higher after inadequate versus adequate RT. Five of 9 and 2 of 5 trials reported significantly worse overall and progression-free survival after poor-quality RT, respectively. One reported a significant correlation, and 2 reported nonsignificant trends toward increased toxicity with noncompliant RT. Although more data are required, protocol-compliant RT may decrease failure rates and increase overall survival and likely contributes to the ability of collected data to answer the central trial question.« less

Characterisation and reproduction of yellow pigments used in central Italy for decorating ceramics during Renaissance

NASA Astrophysics Data System (ADS)

Bultrini, G.; Fragalà, I.; Ingo, G. M.; Lanza, G.

2006-06-01

This study presents the characterisation of prototypical yellow pigments used during the Renaissance period in Italy and the successful reproduction of homologous materials in accordance with the ancient recipes. Moreover, a large number of yellow decorative layers of Sicilian ceramic artefacts dated back from 13th to the 19th century have been selected and the main chemical, structural and minero-petrografic features have been studied by X-ray diffraction, optical microscopy and scanning electron microscopy-energy dispersive spectrometry. These results have been compared with literature data of some yellow decorations of Renaissance ceramics made in central Italy. Comparison has also been made with homologous materials that have been successfully reproduced in accordance with ancient recipes described by Cipriano Piccolpasso in the textbook: “I Tre Libri dell’Arte del Vasaio” using the same ingredients proposed by this artist. Such yellow materials reproduce the typical yellow colorants used by craftsmen of relevant sites for ceramic fabrication in central Italy, namely Città di Castello, Urbino and Castel Durante, during the 16th century. Comparative arguments have shown some intriguing differences that are indicators of both technological transfer processes between central and southern Italy as well as of some local implementations likely due to specific raw materials locally available.

Does Quality of Radiotherapy Predict Outcomes of Multicentre Cooperative Group Trials? A Literature Review

PubMed Central

Fairchild, Alysa; Straube, William; Laurie, Fran; Followill, David

2013-01-01

Central review of radiotherapy (RT) delivery within multicentre clinical trials was initiated in the early 1970’s in the USA. Early quality assurance (QA) publications often focused on metrics related to process, logistics and timing. Our objective was to review the available evidence supporting correlation of RT quality with clinical outcomes within cooperative group trials. Medline search was performed to identify multicentre studies which described central subjective assessment of RT protocol compliance (quality). Data abstracted included method of central review, definition of deviations, and clinical outcomes. Seventeen multicentre studies (1980–2012) were identified, plus one Patterns of Care Study. Disease sites were hematologic, head and neck, lung, breast and pancreas. Between 0% and 97% of treatment plans received an overall grade of acceptable. In seven trials, failure rates were significantly higher after inadequate versus adequate RT. 5/9 and 2/5 trials reported significantly worse overall and progression-free survival after poor quality RT, respectively. One reported a significant correlation and two reported non-significant trends towards increased toxicity with non-compliant RT. Although more data are required, protocol-compliant RT may decrease failure rates and increase overall survival and likely contributes to the ability of collected data to answer the central trial question. PMID:23683829

kmos: A lattice kinetic Monte Carlo framework

NASA Astrophysics Data System (ADS)

Hoffmann, Max J.; Matera, Sebastian; Reuter, Karsten

2014-07-01

Kinetic Monte Carlo (kMC) simulations have emerged as a key tool for microkinetic modeling in heterogeneous catalysis and other materials applications. Systems, where site-specificity of all elementary reactions allows a mapping onto a lattice of discrete active sites, can be addressed within the particularly efficient lattice kMC approach. To this end we describe the versatile kmos software package, which offers a most user-friendly implementation, execution, and evaluation of lattice kMC models of arbitrary complexity in one- to three-dimensional lattice systems, involving multiple active sites in periodic or aperiodic arrangements, as well as site-resolved pairwise and higher-order lateral interactions. Conceptually, kmos achieves a maximum runtime performance which is essentially independent of lattice size by generating code for the efficiency-determining local update of available events that is optimized for a defined kMC model. For this model definition and the control of all runtime and evaluation aspects kmos offers a high-level application programming interface. Usage proceeds interactively, via scripts, or a graphical user interface, which visualizes the model geometry, the lattice occupations and rates of selected elementary reactions, while allowing on-the-fly changes of simulation parameters. We demonstrate the performance and scaling of kmos with the application to kMC models for surface catalytic processes, where for given operation conditions (temperature and partial pressures of all reactants) central simulation outcomes are catalytic activity and selectivities, surface composition, and mechanistic insight into the occurrence of individual elementary processes in the reaction network.

The Relationship Between Intrinsic and Extrinsic Factors and Central Venous Catheter Infections in the Acutely Ill Patient

DTIC Science & Technology

1991-01-01

central venous catheter is inserted into the bloodstream, a fibrin sheath forms around the cannula which attracts bacteria . Bacteria can either migrate from...to the fibrin sheath. After colonization of the fibrin sheath, the bacteria replicate and are released into the bloodstream when symptoms may develop...culture." Rose et al. (1988, p. 511) defined catheter site infection as occurring when "cultures at the exit site are identical to bacteria found on

Central Atlantic regional ecological test site

NASA Technical Reports Server (NTRS)

Alexander, R. H.

1972-01-01

The work of the Central Atlantic Regional Ecological Test Site (CARETS) project is discussed. The primary aim of CARETS is to test the hypothesis that data from ERTS-A can be made an integral part of a regional land resources information system, encompassing both inventory of the resource base and monitoring of changes, along with their effects on the quality of the environment. Another objective of the project is to determine scaling factors for developing land use information and regional analysis for regions of any given size.

7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT WAS BUILT ON THE SITE WITH FOUR SEPARATE PRODUCTION AREAS, AND AN ADMINISTRATION AND SUPPORT AREA. THIS PHOTOGRAPH SHOWS THE EASTERN EDGE OF THE CORE ADMINSTRATION AND SUPPORT AREA, BUILT IN THE EARLY 1950S. IN THE LEFT FOREGROUND OF THE PHOTOGRAPH IS BUILDING 442, USED TO TEST ALL HEPA FILTERS ON SITE. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

The Model Industrial Technology Systems Project.

ERIC Educational Resources Information Center

Bowling Green State Univ., OH.

This document contains materials used in a model industrial technology program that introduced technology into the curricula of elementary, middle, and high schools in three sites in Ohio: the Central site (coordinated through Ohio State University); the Northeast site (coordinated through Kent State University); and the Northwest site…

Preliminary report on engineering geology of thirteen tunnel sites, Nevada Test Site

USGS Publications Warehouse

Wilmarth, Verl Richard; McKeown, Francis Alexander; Dobrovolny, Ernest

1958-01-01

Reconnaissance of 13 areas in and adjacent to Nevada Test Site was completed. Of the 13 areas, Forty Mile Canyon, South-central Shoshone Mountain, and Southeast Shoshone Mountain named in order of preference, offer many advantages for carrying on future underground nuclear explosions.

Alluvial diamond resource potential and production capacity assessment of the Central African Republic

USGS Publications Warehouse

Chirico, Peter G.; Barthelemy, Francis; Ngbokoto, Francois A.

2010-01-01

In May of 2000, a meeting was convened in Kimberley, South Africa, and attended by representatives of the diamond industry and leaders of African governments to develop a certification process intended to assure that rough, exported diamonds were free of conflict concerns. This meeting was supported later in 2000 by the United Nations in a resolution adopted by the General Assembly. By 2002, the Kimberly Process Certification Scheme (KPCS) was ratified and signed by diamond-producing and diamond-importing countries. Over 70 countries were included as members of the KPCS at the end of 2007. To prevent trade in "conflict diamonds" while protecting legitimate trade, the KPCS requires that each country set up an internal system of controls to prevent conflict diamonds from entering any imported or exported shipments of rough diamonds. Every diamond or diamond shipment must be accompanied by a Kimberley Process (KP) certificate and be contained in tamper-proof packaging. The objective of this study was (1) to assess the naturally occurring endowment of diamonds in the Central African Republic (potential resources) based on geological evidence, previous studies, and recent field data and (2) to assess the diamond-production capacity and measure the intensity of mining activity. Several possible methods can be used to estimate the potential diamond resource. However, because there is generally a lack of sufficient and consistent data recording all diamond mining in the Central African Republic and because time to conduct fieldwork and accessibility to the diamond mining areas are limited, two different methodologies were used: the volume and grade approach and the content per kilometer approach. Estimates are that approximately 39,000,000 carats of alluvial diamonds remain in the eastern and western zones of the CAR combined. This amount is roughly twice the total amount of diamonds reportedly exported from the Central African Republic since 1931. Production capacity is calculated to be 840,000 carats per year, a number that is nearly twice the 450,000 carats per year reported annually by the Central African Republic. The difference in the two numbers reflects the lack of sufficient data on diamond resource grades, worker productivity, and the number and locations of sites being worked.

Bacterial contamination on touch surfaces in the public transport system and in public areas of a hospital in London.

PubMed

Otter, J A; French, G L

2009-12-01

To investigate bacterial contamination on hand-touch surfaces in the public transport system and in public areas of a hospital in central London. Dipslides were used to sample 118 hand-touch surfaces in buses, trains, stations, hotels and public areas of a hospital in central London. Total aerobic counts were determined, and Staphylococcus aureus isolates were identified and characterized. Bacteria were cultured from 112 (95%) of sites at a median concentration of 12 CFU cm(-2). Methicillin-susceptible Staph. aureus (MSSA) was cultured from nine (8%) of sites; no sites grew methicillin-resistant Staph. aureus (MRSA). Hand-touch sites in London are frequently contaminated with bacteria and can harbour MSSA, but none of the sites tested were contaminated with MRSA. Hand-touch sites can become contaminated with staphylococci and may be fomites for the transmission of bacteria between humans. Such sites could provide a reservoir for community-associated MRSA (CA-MRSA) in high prevalence areas but were not present in London, a geographical area with a low incidence of CA-MRSA.

Chemical characteristics of soluble aerosols over the central Himalayas: insights into spatiotemporal variations and sources.

PubMed

Tripathee, Lekhendra; Kang, Shichang; Rupakheti, Dipesh; Cong, Zhiyuan; Zhang, Qianggong; Huang, Jie

2017-11-01

In order to investigate the spatial and temporal variations of aerosols and its soluble chemical compositions of the data gap zone in the central Himalayan region, aerosol samples were collected at four sites. The sampling location were characterized by four different categories, such as urban (Bode), semi-urban site in the northern Indo-Gangetic Plain (Lumbini), rural (Dhunche), and semiarid rural (Jomsom). A total of 230 aerosol samples were collected from four representative sites for a yearlong period and analyzed for water-soluble inorganic ions (WSIIs). The annual average aerosol mass concentration followed the sequence as Bode (238.24 ± 162.24 μg/m 3 )> Lumbini (161.14 ± 105.95 μg/m 3 )> Dhunche (112.40 ± 40.30 μg/m 3 )> Jomsom (78.85 ± 34.28 μg/m 3 ), suggesting heavier particulate pollution in the urban and semi-urban sites. The total soluble ions contributed to 12.61-28.19% of TSP aerosol mass. The results revealed that SO 4 2- and NO 3 - were the major anion and Ca 2+ and NH 4 + were the major cation influencing the aerosol composition over the central Himalayas. Calcium played a major role in neutralizing aerosol acidity followed by NH 4 + at all the sites. The major compound of aerosol was (NH 4 ) 2 SO 4 and NH 4 HSO 4 in the central Himalayas. Clear seasonality was observed at three observation sites, with higher concentrations during non-monsoon (dry periods) and lower during monsoon (wet period), suggesting washing out of aerosol particles by heavy precipitation during monsoon. In contrast, semiarid sites did not show the clear seasonal trend due to limited precipitation. Stationary sources were predominant over the mobile sources mostly in the remote sites. Principal component analysis confirmed that the major sources of WSIIs in the region were industrial emissions, fossil fuel and biomass burning, and crustal fugitive dusts. Nevertheless, transboundary aerosol transport over the region from polluted cities from south Asia could not be ignored as indicated by the clusters of air mass backward trajectory analysis.

Dynamic frontotemporal systems process space and time in working memory

PubMed Central

Adams, Jenna N.; Solbakk, Anne-Kristin; Endestad, Tor; Larsson, Pål G.; Ivanovic, Jugoslav; Meling, Torstein R.; Lin, Jack J.; Knight, Robert T.

2018-01-01

How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL–PFC interactions underlie working memory for everyday experiences. PMID:29601574

Carbon Characteristics and Biogeochemical Processes of Uranium Accumulating Organic Matter Rich Sediments in the Upper Colorado River Basin

NASA Astrophysics Data System (ADS)

Boye, K.; Noel, V.; Tfaily, M. M.; Dam, W. L.; Bargar, J.; Fendorf, S. E.

2015-12-01

Uranium plume persistence in groundwater aquifers is a problem on several former ore processing sites on floodplains in the upper Colorado River Basin. Earlier observations by our group and others at the Old Rifle Site, CO, have noted that U concentrations are highest in organic rich, fine-grained, and, therefore, diffusion limited sediment material. Due to the constantly evolving depositional environments of floodplains, surficial organic matter may become buried at various stages of decomposition, through sudden events such as overbank flooding and through the slower progression of river meandering. This creates a discontinuous subsurface distribution of organic-rich sediments, which are hotspots for microbial activity and thereby central to the subsurface cycling of contaminants (e.g. U) and biologically relevant elements (e.g. C, N, P, Fe). However, the organic matter itself is poorly characterized. Consequently, little is known about its relevance in driving biogeochemical processes that control U fate and transport in the subsurface. In an investigation of soil/sediment cores from five former uranium ore processing sites on floodplains distributed across the Upper Colorado River Basin we confirmed consistent co-enrichment of U with organic-rich layers in all profiles. However, using C K-edge X-ray Absorption Spectroscopy (XAS) coupled with Fourier-Transformed Ion-Cyclotron-Resonance Mass-Spectroscopy (FT-ICR-MS) on bulk sediments and density-separated organic matter fractions, we did not detect any chemical difference in the organic rich sediments compared to the surrounding coarser-grained aquifer material within the same profile, even though there were differences in organic matter composition between the 5 sites. This suggests that U retention and reduction to U(IV) is independent of C chemical composition on the bulk scale. Instead it appears to be the abundance of organic matter in combination with a limited O2 supply in the fine-grained material that stimulate anaerobic microbial processes responsible for U enrichment. Thus, the chemical composition of organic matter is subordinate to the physical environment and total organic matter content in controlling U reduction and retention processes.

Modified nucleotides reveal the indirect role of the central base pairs in stabilizing the lac repressor-operator complex.

PubMed Central

Zhang, X; Gottlieb, P A

1995-01-01

Guanine residues in the lac operator were replaced by 2-aminopurine or purine analogues, pairing the modified nucleotides with C. The observed equilibrium dissociation constants for lac repressor binding to substituted operators were measured in 10 mM Tris, 150 mM KCl, 0.1 mM EDTA, 0.1 mM DTE, pH 7.6 at 25 degrees C. These measurements revealed five positions that destabilized the complex when substituted with either analogue. Two positions, which are related by a 2-fold symmetry, are in the major groove of the operator thought to directly interact with the protein. Three sites were in the central region of the operator. A purine analogue at a sixth site perturbed the local DNA structure and destabilized the complex. Alkylation interference experiments of the 2-aminopurine substituted operators demonstrated that, of the five affected, two substitutions displayed altered phosphate interference patterns at the phosphate adjacent to the substituted base. For these operators, complex formation was measured in different concentrations of KCl to assess the contribution of counterion release to the bimolecular process. The results indicated that both complexes were similar to wild-type, although minor changes were observed. The Kobs of the complex was then measured when 2-aminopurine or purine analogues were paired with uracil nucleotide, a base pair that serves to stabilize the DNA. The introduction of the new base pairs revealed two effects on the bimolecular interaction. For those operator sites that are thought to perturb the interaction directly, the affinity of the complex was weakened to levels observed for the singly-substituted operators. In contrast, the nucleotides of 2-aminopurine paired with uracil positioned in the central region of the operator served to enhance the stability of the complex. The purine-uracil base pair substitution on the other hand had a significant destabilizing effect on the interaction. We propose that the central base pairs modulate binding of the complex by altering the intrinsic properties of the DNA. Two specific attributes are required to achieve the lowest free energy of interaction. The DNA must have two interstrand hydrogen bonds to stabilize the duplex and it must have properties associated with directional bending or unwinding. This analysis does not rule out contributions by direct interactions between the protein and the central region of the operator but underscores how indirect effects play a major role in complex formation in this system. Images PMID:7784203

Experimental studies in natural groundwater-recharge dynamics: The analysis of observed recharge events

USGS Publications Warehouse

Sophocleous, M.; Perry, C.A.

1985-01-01

The amounts and time distribution of groundwater recharge from precipitation over an approximately 19-month period were investigated at two instrumented sites in south-central Kansas. Precipitation and evapotranspiration sequences, soil-moisture profiles and storage changes, water fluxes in the unsaturated zone and hydraulic gradients in the saturated zone at various depths, soil temperatures, water-table hydrographs, and water-level changes in nearby wells clearly depict the recharge process. Antecedent moisture conditions and the thickness and nature of the unsaturated zone were found to be the major factors affecting recharge. Although the two instrumented sites are located in sand-dune environments in areas characterized by shallow water table and subhumid continental climate, a significant difference was observed in the estimated effective recharge. The estimates ranged from less than 2.5 to approximately 154 mm at the two sites from February to June 1983. The main reasons for this large difference in recharge estimates were the greater thickness of the unsaturated zone and the lower moisture content in that zone resulting from lower precipitation and higher potential evapotranspiration for one of the sites. Effective recharge took place only during late winter and spring. No summer or fall recharge was observed at either site during the observation period of this study. ?? 1985.

Optimal design of compact and connected nature reserves for multiple species.

PubMed

Wang, Yicheng; Önal, Hayri

2016-04-01

When designing a conservation reserve system for multiple species, spatial attributes of the reserves must be taken into account at species level. The existing optimal reserve design literature considers either one spatial attribute or when multiple attributes are considered the analysis is restricted only to one species. We built a linear integer programing model that incorporates compactness and connectivity of the landscape reserved for multiple species. The model identifies multiple reserves that each serve a subset of target species with a specified coverage probability threshold to ensure the species' long-term survival in the reserve, and each target species is covered (protected) with another probability threshold at the reserve system level. We modeled compactness by minimizing the total distance between selected sites and central sites, and we modeled connectivity of a selected site to its designated central site by selecting at least one of its adjacent sites that has a nearer distance to the central site. We considered structural distance and functional distances that incorporated site quality between sites. We tested the model using randomly generated data on 2 species, one ground species that required structural connectivity and the other an avian species that required functional connectivity. We applied the model to 10 bird species listed as endangered by the state of Illinois (U.S.A.). Spatial coherence and selection cost of the reserves differed substantially depending on the weights assigned to these 2 criteria. The model can be used to design a reserve system for multiple species, especially species whose habitats are far apart in which case multiple disjunct but compact and connected reserves are advantageous. The model can be modified to increase or decrease the distance between reserves to reduce or promote population connectivity. © 2015 Society for Conservation Biology.

Central Core Laboratory versus Site Interpretation of Coronary CT Angiography: Agreement and Association with Cardiovascular Events in the PROMISE Trial.

PubMed

Lu, Michael T; Meyersohn, Nandini M; Mayrhofer, Thomas; Bittner, Daniel O; Emami, Hamed; Puchner, Stefan B; Foldyna, Borek; Mueller, Martin E; Hearne, Steven; Yang, Clifford; Achenbach, Stephan; Truong, Quynh A; Ghoshhajra, Brian B; Patel, Manesh R; Ferencik, Maros; Douglas, Pamela S; Hoffmann, Udo

2018-04-01

Purpose To assess concordance and relative prognostic utility between central core laboratory and local site interpretation for significant coronary artery disease (CAD) and cardiovascular events. Materials and Methods In the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial, readers at 193 North American sites interpreted coronary computed tomographic (CT) angiography as part of the clinical evaluation of stable chest pain. Readers at a central core laboratory also interpreted CT angiography blinded to clinical data, site interpretation, and outcomes. Significant CAD was defined as stenosis greater than or equal to 50%; cardiovascular events were defined as a composite of cardiovascular death or myocardial infarction. Results In 4347 patients (51.8% women; mean age ± standard deviation, 60.4 years ± 8.2), core laboratory and site interpretations were discordant in 16% (683 of 4347), most commonly because of a finding of significant CAD by site but not by core laboratory interpretation (80%, 544 of 683). Overall, core laboratory interpretation resulted in 41% fewer patients being reported as having significant CAD (14%, 595 of 4347 vs 23%, 1000 of 4347; P < .001). Over a median follow-up period of 25 months, 1.3% (57 of 4347) sustained myocardial infarction or cardiovascular death. The C statistic for future myocardial infarction or cardiovascular death was 0.61 (95% confidence interval [CI]: 0.54, 0.68) for the core laboratory and 0.63 (95% CI: 0.56, 0.70) for the sites. Conclusion Compared with interpretation by readers at 193 North American sites, standardized core laboratory interpretation classified 41% fewer patients as having significant CAD. © RSNA, 2017 Online supplemental material is available for this article. Clinical trial registration no. NCT01174550.

Analysis of ILRS Site Ties

NASA Astrophysics Data System (ADS)

Husson, V. S.; Long, J. L.; Pearlman, M.

2001-12-01

By the end of 2000, 94% of ILRS stations had completed station and site information forms (i.e. site logs). These forms contain six types of information. These six categories include site identifiers, contact information, approximate coordinates, system configuration history, system ranging capabilities, and local survey ties. The ILRS Central Bureau, in conjunction with the ILRS Networks and Engineering Working Group, has developed procedures to quality control site log contents. Part of this verification entails data integrity checks of local site ties and is the primary focus of this paper. Local survey ties are critical to the combination of space geodetic network coordinate solutions (i.e. GPS, SLR, VLBI, DORIS) of the International Terrestrial Reference Frame (ITRF). Approximately 90% of active SLR sites are collocated with at least one other space geodetic technique. The process used to verify these SLR ties, at collocated sites, is identical to the approach used in ITRF2000. Local vectors (X, Y, Z) from each ILRS site log are differenced from its corresponding ITRF2000 position vectors (i.e. no transformations). These X, Y, and Z deltas are converted into North, East, and Up. Any deltas, in any component, larger than 5 millimeter is flagged for investigation. In the absence of ITRF2000 SLR positions, CSR positions were used. To further enhance this comparison and to fill gaps in information, local ties contained in site logs from the other space geodetic services (i.e. IGS, IVS, IDS) were used in addition to ITRF2000 ties. Case studies of two collocated sites (McDonald/Ft. Davis and Hartebeeshtoek) will be explored in-depth. Recommendations on how local site surveys should be conducted and how this information should be managed will also be presented.

Developments in ambient noise analysis for the characterization of dynamic response of slopes to seismic shaking

NASA Astrophysics Data System (ADS)

Del Gaudio, Vincenzo; Wasowski, Janusz

2016-04-01

In the last few decades, we have witnessed a growing awareness of the role of site dynamic response to seismic shaking in slope failures during earthquakes. Considering the time and costs involved in acquiring accelerometer data on landslide prone slopes, the analysis of ambient noise offers a profitable investigative alternative. Standard procedures of ambient noise analysis, according to the technique known as HVNR or Nakamura's method, were originally devised to interpret data under simple site conditions similar to 1D layering (flat horizontal layering infinitely extended). In such cases, conditions of site amplification, characterized by a strong impedance contrast between a soft surface layer and a stiff bedrock, result in a single pronounced isotropic maximum of spectral ratios between horizontal and vertical component of ambient noise. However, previous studies have shown that the dynamic response of slopes affected by landslides is rather complex, being characterized by multiple resonance peaks with directional variability, thus, the use of standard techniques can encounter difficulties in providing reliable information. A new approach of data analysis has recently been proposed to exploit the potential of information content of Rayleigh waves present in ambient noise, with regard to the identification of frequency and orientation of directional resonance. By exploiting ground motion ellipticity this approach can also provide information on vertical distribution of S-wave velocity, which controls site amplification factors. The method, based on the identification of Rayleigh wave packets from instantaneous polarization properties of ambient noise, was first tested using synthetic signals in order to optimize the data processing system. Then the improved processing scheme is adopted to re-process and re-interpret the ambient noise data acquired on landslide prone slopes around Caramanico Terme (central Italy), at sites monitored also with accelerometer stations. The comparison of ambient noise analysis results with the outcomes of accelerometer monitoring reveals potential and limits of the new method for the investigations on slope dynamic response.

The role of DOM in nitrogen processing in streams across arctic regions affected by fire

NASA Astrophysics Data System (ADS)

Rodriguez-Cardona, B.; Schade, J. D.; Holmes, R. M.; Natali, S.; Mann, P. J.; Wymore, A.; Coble, A. A.; Prokishkin, A. S.; Zito, P.; Podgorski, D. C.; Spencer, R. G.; McDowell, W. H.

2017-12-01

In stream ecosystems, inputs of dissolved organic carbon (DOC) have a strong influence on nitrogen (N) processing. Previous studies have demonstrated that increases in DOC concentrations can promote greater N removal in many stream ecosystems. Most of what we know about C and N coupling comes from studies of temperate streams; less is known about this relationship in the Arctic. Streams in Arctic ecosystems are facing rapid changes in climate and disturbance regimes, in particular increasing fire frequencies that are likely to alter biogeochemical cycles. Although fires can lead to increases in NO3 concentrations in streams, the effects of fire on DOC (concentration and composition) have been difficult to generalize. We studied the relationships between DOC and N in two locations; the Central Siberian Plateau, Russia and the Yukon-Kuskokwim (YK) River Delta, Alaska. Streams in both regions show increases in NO3 concentrations after fire, while DOC concentrations decrease in Siberia but increase in streams within the YK-Delta. These patterns in DOC and NO3 create a gradient in DOC and nutrient concentrations, allowing us to study this coupling in a wider Pan-Arctic scope. In order to assess the role of DOC in Arctic N processing, we conducted NO3 and NH4 additions to stream microcosms at the Alaskan site as well as whole-stream additions in Siberia. We hypothesized that nutrient uptake would be high in older burn sites of Siberia and recently burned sites in the YK-Delta, due to greater DOC concentrations and availability. Our results suggest that nitrogen dynamics in the Alaskan sites is strongly responsive to C availability, but is less so in Siberian sites. The potential impacts of permafrost thawing and fires on DOM and nutrient dynamics thus appear to not be consistent across the Arctic suggesting that different regions of the Arctic have unique biogeochemical controls.

The Role of Inhibitory Control in Behavioral and Physiological Expressions of Toddler Executive Function

PubMed Central

Morasch, Katherine C.; Bell, Martha Ann

2010-01-01

Eighty-one toddlers (ranging from 24 to 27 months) participated in a biobehavioral investigation of inhibitory control. Maternal-report measures of inhibitory control were related to laboratory tasks assessing inhibitory abilities under conditions of conflict, delay, and compliance challenge as well as toddler verbal ability. Additionally, unique variance in inhibitory control was explained by task-related changes in brain electrical activity at lateral frontal scalp sites as well as concurrent inhibitory task performance. Implications regarding neural correlates of executive function in early development and a central, organizing role of inhibitory processing in toddlerhood are discussed. PMID:20719337

Big data sharing and analysis to advance research in post-traumatic epilepsy.

PubMed

Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Nina; Toga, Arthur W

2018-06-01

We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data across modalities and sites, and searching content. We have developed and applied innovative image and electrophysiology processing methods to identify candidate biomarkers from MRI, EEG, and multi-modal data. Based on heterogeneous biomarkers, we present novel analytic tools designed to study epileptogenesis in animal model and human with the goal of tracking the probability of developing epilepsy over time. Copyright © 2017. Published by Elsevier Inc.

MX Siting Investigation. Prime Characterization Sites Central High Plains Candidate Siting Province.

DTIC Science & Technology

1979-02-15

information obtained from these studies , in combination with data obtained in the Screen- ing studies , has been used for geotechnical ranking (FN-TR-25). I...Plains Candi- date Siting Province (CSP), one of six provinces included in the geotechnical Characterization studies . The location of the sites within...remaining after Intermediate Screening were divided into CSPs based on similar geotechnical characteristics. Intermediate Screening studies (FN-TR-17

Properties and chemical constituents in ground water from the middle Claiborne Aquifer, Gulf Coast regional aquifer systems, south-central United States

USGS Publications Warehouse

Pettijohn, Robert A.; Busby, John F.; Cervantes, Michael A.

1993-01-01

The U.S. Geological Survey used four programs in 1990 to provide external data quality assurance for the National Atmospheric Deposition Program/National Trends Network (NADP/NTN). Results of the intersite- comparison program indicate that 80 and 74 percent of the site operators met the NADP/NTN goals for pH determination and 98 and 95 percent of the site operators met the NADP/NTN goals for specific- conductance determination during the two studies in 1990. The effects of routine sample handling, processing, and shipping determined in the blind-audit program indicated significant positive bias for calcium, magnesium, sodium, potassium, chloride, nitrate, and sulfate. Significant negative bias was determined for hydrogen ion and specific conductance. A Kruskal-Wallis test indicated that there were no significant (a=0.01) differences in analytical results from the three laboratories participating in the interlaboratory-comparison program. Results from the collocated-sampler study indicate the median relative error for potassium and ammonium concentration and deposition exceeded 15 percent at most sites while the median relative error for sulfate and nitrate at all sites was less than 6 percent for concentration and was less than 15 percent for deposition.

AmeriFlux US-A74 ARM SGP milo field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kueppers, Lara; Torn, Margaret; Biraud, Sebastien

This is the AmeriFlux version of the carbon flux data for the site US-A74 ARM SGP milo field. Site Description - This site is located near the ARM SGP Central Facility at the intersection of Oklahoma highways 11 and 74, 16.5 km East of Medford, OK

Running and testing GRID services with Puppet at GRIF- IRFU

NASA Astrophysics Data System (ADS)

Ferry, S.; Schaer, F.; Meyer, JP

2015-12-01

GRIF is a distributed Tiers 2 centre, made of 6 different centres in the Paris region, and serving many VOs. The sub-sites are connected with 10 Gbps private network and share tools for central management. One of the sub-sites, GRIF-IRFU held and maintained in the CEA- Saclay centre, moved a year ago, to a configuration management using Puppet. Thanks to the versatility of Puppet/Foreman automation, the GRIF-IRFU site maintains usual grid services, with, among them: a CREAM-CE with a TORQUE+Maui (running a batch with more than 5000 jobs slots), a DPM storage of more than 2 PB, a Nagios monitoring essentially based on check_mk, as well as centralized services for the French NGI, like the accounting, or the argus central suspension system. We report on the actual functionalities of Puppet and present the last tests and evolutions including a monitoring with Graphite, a HT-condor multicore batch accessed with an ARC-CE and a CEPH storage file system.

Field Review of Fish Habitat Improvement Projects in Central Idaho.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beschta, Robert L.; Griffith, Jack; Wesche, Thomas A.

1993-05-01

The goal of this field review was to provide information to the Bonneville Power Administration (BPA) regarding previous and ongoing fish habitat improvement projects in central Idaho. On July 14, 1992, the review team met at the Sawtooth National Recreation Area office near Ketchum, Idaho, for a slide presentation illustrating several habitat projects during their construction phases. Following the slide presentation, the review team inspected fish habitat projects that have been implemented in the last several years in the Stanley Basin and adjacent valleys. At each site the habitat project was described to the field team and a brief periodmore » for project inspection followed. The review team visited approximately a dozen sites on the Challis, Sawtooth, and Boise National Forests over a period of approximately two and a half days. There are two objectives of this review namely to summarize observations for specific field sites and to provide overview commentary regarding the BPA habitat improvement program in central Idaho.« less

Surface ozone at Nam Co in the inland Tibetan Plateau: variation, synthesis comparison and regional representativeness

NASA Astrophysics Data System (ADS)

Yin, Xiufeng; Kang, Shichang; de Foy, Benjamin; Cong, Zhiyuan; Luo, Jiali; Zhang, Lang; Ma, Yaoming; Zhang, Guoshuai; Rupakheti, Dipesh; Zhang, Qianggong

2017-09-01

Ozone is an important pollutant and greenhouse gas, and tropospheric ozone variations are generally associated with both natural and anthropogenic processes. As one of the most pristine and inaccessible regions in the world, the Tibetan Plateau has been considered as an ideal region for studying processes of the background atmosphere. Due to the vast area of the Tibetan Plateau, sites in the southern, northern and central regions exhibit different patterns of variation in surface ozone. Here, we present continuous measurements of surface ozone mixing ratios at Nam Co Station over a period of ˜ 5 years (January 2011 to October 2015), which is a background site in the inland Tibetan Plateau. An average surface ozone mixing ratio of 47.6 ± 11.6 ppb (mean ± standard deviation) was recorded, and a large annual cycle was observed with maximum ozone mixing ratios in the spring and minimum ratios during the winter. The diurnal cycle is characterized by a minimum in the early morning and a maximum in the late afternoon. Nam Co Station represents a background region where surface ozone receives negligible local anthropogenic emissions inputs, and the anthropogenic contribution from South Asia in spring and China in summer may affect Nam Co Station occasionally. Surface ozone at Nam Co Station is mainly dominated by natural processes involving photochemical reactions, vertical mixing and downward transport of stratospheric air mass. Model results indicate that the study site is affected differently by the surrounding areas in different seasons: air masses from the southern Tibetan Plateau contribute to the high ozone levels in the spring, and enhanced ozone levels in the summer are associated with air masses from the northern Tibetan Plateau. By comparing measurements at Nam Co Station with those from other sites on the Tibetan Plateau, we aim to expand the understanding of ozone cycles and transport processes over the Tibetan Plateau. This work may provide a reference for future model simulations.

Melatonin receptors: Current status, facts, and hypothesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stankov, B.; Reiter, R.J.

Great progress has been made in the identification of melatonin binding sites, commonly identified as melatonin receptors by many authors, in recent years. The bulk of these studies have investigated the sites using either autoradiographic and biochemical techniques with the majority of the experiments being done on the rat, Djungarian and Syrian hamster, and sheep, although human tissue has also been employed. Many of the studies have identified melatonin binding in the central nervous system with either tritium- or iodine-labelled ligands. The latter ligand seems to provide the most reproducible and consistent data. Of the central neural tissues examined, themore » suprachiasmatic nuclei are most frequently mentioned as a location for melatonin binding sites although binding seems to be widespread in the brain. The other tissue that has been prominently mentioned as a site for melatonin binding is the pars tuberalis of the anterior pituitary gland. There may be time-dependent variations in melatonin binding densities in both neural and pituitary gland tissue. Very few attempts have been made to identify melatonin binding outside of the central nervous system despite the widespread actions of melatonin. Preliminary experiments have been carried out on the intracellular second messengers which mediate the actions of melatonin.« less

Dredged Material Management in Long Island Sound

EPA Pesticide Factsheets

Information on Western and Central Long Island Sound Dredged Material Disposal Sites including the Dredged Material Management Plan and Regional Dredging Team. Information regarding the Eastern Long Island Sound Selected Site including public meetings.

Classification and evaluation for forest sites on the Northern Cumberland Plateau

Treesearch

Glendon W. Smalley

1986-01-01

Presents a comprehensive forest site classifictation system for the North Cumberland Plateau in north-central Tennessee and eastern Kentucky. The system is based on physiograhpy, geology, soils, topography, and vegetation.

Overland flow, sediment output and nutrient loss from certain forested sites in the central Himalaya, India

NASA Astrophysics Data System (ADS)

Pathak, P. C.; Pandey, A. N.; Singh, J. S.

1984-03-01

Overland flow, sediment output and input and output of precipitation nutrients were evaluated on six forested sites in the central Himalaya during the 1981 and 1982 monsoon seasons. Overland flow was significantly different across the forests and the months of the rainy season. It was positively related with rainfall quantity and intensity, and was negatively related with tree canopy cover and with ground vegetation cover. Average overland flow was only 0.66% of the total incident rainfall, indicating that these sites are subsurface-flow systems. Sediment output was positively related to overland flow. Rainfall added a significant amount of nutrients to the forests. This extra-system input was greater than loss through overland flow + sediment output. The loss of nutrients from the forested sites was in the order: Mg > C > Ca > K = N = P.

Measuring site index in the central hardwood region

Treesearch

Robert A. McQuilkin

1989-01-01

Site index is the average height of dominant and codominant trees growing in well-stocked, even-aged stands at a given age called ?index age.? Fifty years is the most commonly used index age in upland hardwoods. Sometimes 25 or 30 years are used for short-rotation bottomland hardwoods. Site index is widely used to indicate site quality because it correlates well with...

Genetic structure of Heterbasidion annosum in white fir mortality centers in California

Treesearch

M. Garbelotto; F.W. Cobb; T.D. Bruns; William J. Otrosina; Tina Popenuck; Garey Slaughter

1999-01-01

The structure of Heterobasidion annosum populations was studied in 15 mixed-conifer sites in central and northern California. Study sites dis­played mortality of white fir trees in enlarging discrete patches (mortality centers). At each site, fungal genotypes were defined by somatic compat­ibility tests. In two sites, further genetic and molecular...

Crustal-scale electrical conductivity anomaly beneath inflating Lazufre volcanic complex, Central Andes

NASA Astrophysics Data System (ADS)

Budach, Ingmar; Brasse, Heinrich; Díaz, Daniel

2013-03-01

Large-scale surface deformation was observed at Lazufre volcanic center in the Central Andes of Northern Chile/Northwestern Argentina by means of Interferometric Synthetic Aperture Radar (InSAR). Uplift started there after 1998 and increased dramatically in the following years up to a rate of 3 cm/a. Lazufre is now one of the largest deforming volcano systems on Earth, but the cause for uplift - likely influx of magmatic material into the crust - is still poorly understood. In the beginning of 2010 a magnetotelluric survey was conducted to delineate the electrical conductivity distribution in the area. Several long-period magnetotelluric (LMT) sites and two broadband magnetotelluric (BBMT) sites were set up on an EW trending profile crossing the volcanic center; furthermore some LMT sites were arranged circularly around Lazufre complex and adjacent Lastarria volcano. Data were processed using an algorithm for robust and remote reference transfer function estimation. Electrical strike directions were estimated and induction arrows were derived. Although electrical strike is rather ambiguous, in a first step a 2-D resistivity model was calculated. The most prominent feature of this model is a well conducting structure rising from the upper mantle to the shallow crust beneath the center of elevation. This can be interpreted as partial melts ascending from the asthenospheric wedge and feeding a potential magma reservoir beneath Lazufre volcanic center. An improved model is finally achieved by 3-D inversion, supporting this feature. We assume that these rising melts are the source of the observed uplift at Lazufre complex.

Bats in Agroecosytems around California's Central Coast

NASA Astrophysics Data System (ADS)

Wayne, A.

2014-12-01

Bats in agroecosystems around California's Central Coast: A full quarter of California's land area is farmland. Crops account for 32.5 billion of California's GDP. Insect control is a big problem for farmers, and California bats eat only insects, saving farmers an estimated 3 to $53 billion a year. As farmers maximize crop yield, they use more pesticides, herbicides, and fertilizers, which contaminate runoff streams that bats drink from. Also, pesticide use kills bats' sole food source: insects. My research objective was to find out how farm management practices and landscape complexity affect bat diversity and activity, and to see which one affects bat activity more. We monitored 18 sites, including conventional, organic, and low and high-complexity landscapes. We noted more bat activity at sites with high complexity landscapes and organic practices than at sites with either low-complexity landscapes or conventional farming practices. I captured and processed bats and recorded data. I also classified insects collected from light traps. I learned how to handle bats and measure forearm length and weight, as well as how to indentify their gender. I took hair clippings and fecal samples, which yield data about the bats' diet. Their diet, in turn, gives us data about which pests they eat and therefore help control. I also learned about bats' echolocation: they have a special muscle over their ears that closes when they echolocate so that they don't burst their own eardrum. Also, some insects have evolved a special call that will disrupt bats echolocation so bats can't track it.

Osmotically regulated floating asymmetric membrane capsule for controlled site-specific delivery of ranitidine hydrochloride: optimization by central composite design.

PubMed

Chauhan, Manvendra S; Kumar, Anil; Pathak, Kamla

2012-12-01

A nondisintegrating, floating asymmetric membrane capsule (FAMC) was developed to achieve site-specific osmotic flow of a highly water-soluble drug, ranitidine hydrochloride (RHCl), in a controlled manner. Solubility suppression of RHCl was achieved by the common ion effect, using optimized coated sodium chloride as a formulation component. The capsular wall of FAMC was prepared by the phase inversion process wherein the polymeric membrane was precipitated on glass pins by dipping them in a solution of cellulose acetate followed by quenching. Central composite design was utilized to investigate the influence of independent variables, namely, level(s) of membrane former, pore former, and osmogen, on percent cumulative drug release (response). The release mechanism of RHCl through FAMC was confirmed as osmotic pumping. The asymmetry of the membrane was characterized by scanning electron microscopy that revealed a dense nonporous outer region of membrane supported by an inner porous region. Differential scanning calorimetry indicated no incompatibility between the drug and excipients. In vitro drug release in three biorelevant media, pH 2.5 (low fed), pH 4.5 (intermediate fed), and pH 6.5 (high fed), demonstrated pH-independent release of RHCl (P > 0.05). Floating ability for 12 h of the optimized FAMC9 was visually examined during the in vitro release studies that showed maximal drug release with zero-order kinetics (r (2) = 0.9991). Thus, a novel osmotically regulated floating capsular system was developed for site-specific delivery of RHCl.

Long-term responses of sandy beach crustaceans to the effects of coastal armouring after the 2010 Maule earthquake in South Central Chile

NASA Astrophysics Data System (ADS)

Rodil, Iván F.; Jaramillo, Eduardo; Acuña, Emilio; Manzano, Mario; Velasquez, Carlos

2016-02-01

Earthquakes and tsunamis are large physical disturbances frequently striking the coast of Chile with dramatic effects on intertidal habitats. Armouring structures built as societal responses to beach erosion and shoreline retreat are also responsible of coastal squeeze and habitat loss. The ecological implications of interactions between coastal armouring and earthquakes have recently started to be studied for beach ecosystems. How long interactive impacts persist is still unclear because monitoring after disturbance generally extends for a few months. During five years after the Maule earthquake (South Central Chile, February 27th 2010) we monitored the variability in population abundances of the most common crustacean inhabitants of different beach zones (i.e. upper, medium, and lower intertidal) at two armoured (one concrete seawall and one rocky revetment) and one unarmoured sites along the sandy beach of Llico. Beach morphology changed after the earthquake-mediated uplift, restoring upper- and mid-shore armoured levels that were rapidly colonized by typical crustacean species. However, post-earthquake increasing human activities affected the colonization process of sandy beach crustaceans in front of the seawall. Lower-shore crab Emerita analoga was the less affected by armouring structures, and it was the only crustacean species present at the three sites before and after the earthquake. This study shows that field sampling carried out promptly after major disturbances, and monitoring of the affected sites long after the disturbance is gone are effective approaches to increase the knowledge on the interactive effects of large-scale natural phenomena and artificial defences on beach ecology.

E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.

PubMed

Valimberti, Ilaria; Tiberti, Matteo; Lambrughi, Matteo; Sarcevic, Boris; Papaleo, Elena

2015-10-14

Protein phosphorylation is a modification that offers a dynamic and reversible mechanism to regulate the majority of cellular processes. Numerous diseases are associated with aberrant regulation of phosphorylation-induced switches. Phosphorylation is emerging as a mechanism to modulate ubiquitination by regulating key enzymes in this pathway. The molecular mechanisms underpinning how phosphorylation regulates ubiquitinating enzymes, however, are elusive. Here, we show the high conservation of a functional site in E2 ubiquitin-conjugating enzymes. In catalytically active E2s, this site contains aspartate or a phosphorylatable serine and we refer to it as the conserved E2 serine/aspartate (CES/D) site. Molecular simulations of substrate-bound and -unbound forms of wild type, mutant and phosphorylated E2s, provide atomistic insight into the role of the CES/D residue for optimal E2 activity. Both the size and charge of the side group at the site play a central role in aligning the substrate lysine toward E2 catalytic cysteine to control ubiquitination efficiency. The CES/D site contributes to the fingerprint of the E2 superfamily. We propose that E2 enzymes can be divided into constitutively active or regulated families. E2s characterized by an aspartate at the CES/D site signify constitutively active E2s, whereas those containing a serine can be regulated by phosphorylation.

Impact Craters on Earth: Lessons for Understanding Martian Geological Materials and Processes

NASA Astrophysics Data System (ADS)

Osinski, G. R.

2015-12-01

Impact cratering is one of the most ubiquitous geological processes in the Solar System and has had a significant influence on the geological evolution of Mars. Unlike the Moon and Mercury, the Martian impact cratering record is notably diverse, which is interpreted to reflect interactions during the impact process with target volatiles and/or the atmosphere. The Earth also possesses a volatile-rich crust and an atmosphere and so is one of the best analogues for understanding the effects of impact cratering on Mars. Furthermore, fieldwork at terrestrial craters and analysis of samples is critical to ground-truth observations made based on remote sensing data from Martian orbiters, landers, and rovers. In recent years, the effect of target lithology on various aspects of the impact cratering process has emerged as a major research topic. On Mars, volatiles have been invoked to be the primary factor influencing the morphology of ejecta deposits - e.g., the formation of single-, double- and multiple-layered ejecta deposits - and central uplifts - e.g., the formation of so-called "central pit" craters. Studies of craters on Earth have also shown that volatiles complicate the identification of impactites - i.e., rocks produced and/or affected by impact cratering. Identifying impactites on Earth is challenging, often requiring intensive and multi-technique laboratory analysis of hand specimens. As such, it is even more challenging to recognize such materials in remote datasets. Here, observations from the Haughton (d = 23 km; Canada), Ries (d = 24 km; Germany), Mistastin (d = 28 km; Canada), Tunnunik, (d = 28 km; Canada), and West Clearwater Lake (d = 36 km; Canada) impact structures are presented. First, it is shown that some impactites mimic intrusive, volcanic, volcanoclastic and in some cases sedimentary clastic rocks. Care should, therefore, be taken in the identification of seemingly unusual igneous rocks at rover landing sites as they may represent impact melt rocks. Second, it is proposed that layered ejecta deposits on Earth and Mars form from a common multi-stage emplacement model. Third, in terms of the origin of central pit craters it is shown that based on current definitions, these central uplift morphologies also occur on Earth, which offers important insights in their formation.

Human Mars Landing Site and Impacts on Mars Surface Operations

NASA Technical Reports Server (NTRS)

Bussey, Ben; Hoffman, Stephen J.

2016-01-01

NASA has begun a process to identify and discuss candidate locations where humans could land, live and work on the Martian surface. These locations are referred to as Exploration Zones (EZs). Given current mission concepts, an EZ is a collection of Regions of Interest (ROIs) that are located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains a landing site and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. These candidate EZs will be used by NASA as part of a multi-year process of determining where and how humans could explore Mars. In the near term this process includes: (a) identifying locations that would maximize the potential science return from future human exploration missions, (b) identifying locations with the potential for resources required to support humans, (c) developing concepts and engineering systems needed by future human crews to conduct operations within an EZ, and (d) identifying key characteristics of the proposed candidate EZs that cannot be evaluated using existing data sets, thus helping to define precursor measurements needed in advance of human missions. Existing and future robotic spacecraft will be tasked to gather data from specific Mars surface sites within the representative EZs to support these NASA activities. The proposed paper will describe NASA's initial steps for identifying and evaluating candidate EZs and ROIs. This includes plans for the "First Landing Site/Exploration Zone Workshop for Human Missions to the Surface of Mars" to be held in October 2015 at which proposals for EZs and ROIs will be presented and discussed. It will also include a discussion of how these considerations are (or will be) taken into account as future robotic Mars missions are defined and developed. One or more representative EZs, drawn from similar previous studies involving Mars sites, will be used in the proposed paper to illustrate the process NASA envisions for gathering additional data from robotic precursor missions to assist in making a final selection of an EZ for human crews as well as the steps likely to occur during the buildup of a habitation site. Examples of the systems and operations likely to be used by human crews, assisted by robotic vehicles, to explore the scientific ROIs as well as developing the resource ROIs within the example EZs will be discussed.

Meteorological annual report for 1995 at the Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunter, C.H.; Tatum, C.P.

1996-12-01

The Environmental Technology Section (ETS) of the Savannah River Technology Center (SRTC) collects, archives, and analyzes basic meteorological data supporting a variety of activities at SRS. These activities include the design, construction, and operation of nuclear and non-nuclear facilities, emergency response, environmental compliance, resource management, and environmental research. This report contains tabular and graphical summaries of data collected during 1995 for temperature, precipitation, relative humidity, wind, barometric pressure, and solar radiation. Most of these data were collected at the central Climatology Facility. Summaries of temperature and relative humidity were generated with data from the lowest level of measurement at themore » Central Climatology Site tower (13 feet above ground). (Relative humidity is calculated from measurements of dew-point temperature.) Wind speed summaries were generated with data from the second measurement level (58 feet above ground). Wind speed measurements from this level are believed to best represent open, well-exposed areas of the Site. Precipitation summaries were based on data from the Building 773-A site since quality control algorithms for the central Climatology Facility rain gauge data were not finalized at the time this report was prepared. This report also contains seasonal and annual summaries of joint occurrence frequencies for selected wind speed categories by 22.5 degree wind direction sector (i.e., wind roses). Wind rose summaries are provided for the 200-foot level of the Central Climatology tower and for each of the eight 200-foot area towers.« less

Seasonal and distributional patterns of seabirds along the Aleutian Archipelago

USGS Publications Warehouse

Renner, M.; Hunt, G.L.; Piatt, John F.; Byrd, G.V.

2008-01-01

The Aleutian Archipelago is of global importance to seabirds during the northern summer, but little is known about seabird use of these waters during winter. We compare summer and winter abundances of seabirds around 3 islands: Buldir in the western, Kasatochi in the central, and Aiktak in the eastern Aleutians. The density of combined seabird biomass in nearshore marine waters was higher in summer than in winter at Buldir and Kasatochi, but was higher in winter at Aiktak, despite the departure of abundant migratory species. Comparing foraging guilds, we found that only piscivores increased at the western and central sites in winter, whereas at the eastern site several planktivorous species increased as well. The only planktivore remaining in winter at the central and western sites in densities comparable to summer densities was whiskered auklet Aethia pygmaea. Crested auklet Aethia cristatella and thick-billed murre Uria lomvia showed the greatest proportional winter increase at the eastern site. The seasonal patterns of the seabird communities suggest a winter breakdown of the copepod-based food web in the central and western parts of the archipelago, and a system that remains rich in euphausiids in the eastern Aleutians. We suggest that in winter crested auklets take the trophic role that short-tailed shearwaters Puffinus tenuirostris occupy during summer. We hypothesize that advection of euphausiids in the Aleutian North Slope Current is important for supporting the high biomass of planktivores that occupy the Unimak Pass region on a year-round basis. ?? Inter-Research 2008.

Scale-Up Information for Gas-Phase Ammonia Treatment of Uranium in the Vadose Zone at the Hanford Site Central Plateau

DOE Office of Scientific and Technical Information (OSTI.GOV)

Truex, Michael J.; Szecsody, James E.; Zhong, Lirong

Uranium is present in the vadose zone at the Hanford Central Plateau and is of concern for protection of groundwater. The Deep Vadose Zone Treatability Test Plan for the Hanford Central Plateau identified gas-phase treatment and geochemical manipulation as potentially effective treatment approaches for uranium and technetium in the Hanford Central Plateau vadose zone. Based on laboratory evaluation, use of ammonia vapor was selected as the most promising uranium treatment candidate for further development and field testing. While laboratory tests have shown that ammonia treatment effectively reduces the mobility of uranium, additional information is needed to enable deployment of thismore » technology for remediation. Of importance for field applications are aspects of the technology associated with effective distribution of ammonia to a targeted treatment zone, understanding the fate of injected ammonia and its impact on subsurface conditions, and identifying effective monitoring approaches. In addition, information is needed to select equipment and operational parameters for a field design. As part of development efforts for the ammonia technology for remediation of vadose zone uranium contamination, field scale-up issues were identified and have been addressed through a series of laboratory and modeling efforts. This report presents a conceptual description for field application of the ammonia treatment process, engineering calculations to support treatment design, ammonia transport information, field application monitoring approaches, and a discussion of processes affecting the fate of ammonia in the subsurface. The report compiles this information from previous publications and from recent research and development activities. The intent of this report is to provide technical information about these scale-up elements to support the design and operation of a field test for the ammonia treatment technology.« less

Aerosol Chemical and Physical Characterization in Central Amazonia during the 2013 Dry Season

NASA Astrophysics Data System (ADS)

Artaxo, P.; Stern, R.; Brito, J.; Carbone, S.

2015-12-01

During the dry season, the central Amazon forest is highly influenced by forest fires transported through large distances, changing drastically the atmospheric composition even in remote places. This work focuses on a physical-chemical characterization of the aerosol population over a pristine site in Central Amazonia during the dry season. The submicrometer organic aerosols were measured with the Aerodyne ACSM (Aerosol Chemical Speciation Monitor, Aerodyne Inc). Optical properties, size distribution and other micro-physical characteristics were also analyzed. Other instruments were simultaneously used. The measurements were taken during the dry season of 2013 in the Cuieiras ecological reserve (ZF2), northwest of Manaus. The statistical analysis of the data was done with the PMF (Positive Matrix Factorization) technique, in which the organic aerosol was separated into different factors, and then its sources and forming processes were attributed. Results show that the mean aerosol loading was 5,91 μg m-3, from which 78% are of organic composition, 8.5% are sulfate, 6.5% are equivalent black carbon, 4% are ammonium and 3% are nitrate. The mass spectra variability can be explained by 3 factors only, determined with the PMF technique. They were identified as BBOA (Biomass Burning Organic Aerosol), representing 12% of the total organic mass, OOA (Oxygenated Organic Aerosol), representing 66% of the total organic mass and IEPOX-SOA (Isoprene derived Epoxydiol-Secondary Organic Aerosol), representing 21% of the total organic mass. Even in remote and pristine regions, Central Amazonia is highly impacted by biomass burning. Biogenic secondary organic aerosols are also present during the dry season, and the suppression of its wet deposition processes increases their concentration. The oxidation level and other physical-chemical characteristics indicate that the long range transport is responsible for the regional range of this impact.

ANALYSIS OF LOTIC MACROINVERTEBRATE ASSEMBLAGES IN CALIFORNIA'S CENTRAL VALLEY

EPA Science Inventory

Using multivariate and cluster analyses, we examined the relaitonships between chemical and physical characteristics and macroinvertebrate assemblages at sites sampled by R-EMAP in California's Central Valley. By contrasting results where community structure was summarized as met...

ITER Central Solenoid Module Fabrication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, John

The fabrication of the modules for the ITER Central Solenoid (CS) has started in a dedicated production facility located in Poway, California, USA. The necessary tools have been designed, built, installed, and tested in the facility to enable the start of production. The current schedule has first module fabrication completed in 2017, followed by testing and subsequent shipment to ITER. The Central Solenoid is a key component of the ITER tokamak providing the inductive voltage to initiate and sustain the plasma current and to position and shape the plasma. The design of the CS has been a collaborative effort betweenmore » the US ITER Project Office (US ITER), the international ITER Organization (IO) and General Atomics (GA). GA’s responsibility includes: completing the fabrication design, developing and qualifying the fabrication processes and tools, and then completing the fabrication of the seven 110 tonne CS modules. The modules will be shipped separately to the ITER site, and then stacked and aligned in the Assembly Hall prior to insertion in the core of the ITER tokamak. A dedicated facility in Poway, California, USA has been established by GA to complete the fabrication of the seven modules. Infrastructure improvements included thick reinforced concrete floors, a diesel generator for backup power, along with, cranes for moving the tooling within the facility. The fabrication process for a single module requires approximately 22 months followed by five months of testing, which includes preliminary electrical testing followed by high current (48.5 kA) tests at 4.7K. The production of the seven modules is completed in a parallel fashion through ten process stations. The process stations have been designed and built with most stations having completed testing and qualification for carrying out the required fabrication processes. The final qualification step for each process station is achieved by the successful production of a prototype coil. Fabrication of the first ITER module is in progress. The seven modules will be individually shipped to Cadarache, France upon their completion. This paper describes the processes and status of the fabrication of the CS Modules for ITER.« less

The posterior cruciate ligament: a study on its bony and soft tissue anatomy using novel 3D CT technology.

PubMed

Van Hoof, Tom; Cromheecke, Michiel; Tampere, Thomas; D'herde, Katharina; Victor, Jan; Verdonk, Peter C M

2013-05-01

The bony insertion sites of the PCL have been studied and described extensively using 2D technology such as macroscopic images, plain radiograph, computerized tomography (CT) and MRI. The purpose of this study is to visualize both the tibial and the femoral bony insertion sites but also the soft tissue anatomy of the native PCL using novel 3D CT imaging. In addition, new concepts of best-fit cylinder and central axis are introduced and evaluated. Nine unpaired knees of embalmed cadavers were used in this study. Following the dissection process, the PCL was injected with a contrast medium for computed tomography (CT) imaging. The obtained CT images were segmented and rendered in 3D allowing morphological and morphometric analysis of PCL. Femoral and tibial footprint surface area, best-fit PCL-cylinder intersection area, best-fit PCL-cylinder/footprint coverage ratio, best-fit PCL-cylinder central axis projections at the tibial and femoral footprint were used to describe the anatomy of the PCL. Mean footprint surface area of the tibial and femoral footprint were 189.1 and 293.3 mm², respectively. The mean diameter of the best-fit cylinder was 10.5 mm. The mean coverage of the best-fit cylinder on the tibial and femoral footprint was 76.5 and 46.5, respectively. The best-fit cylinder central axis was located in the anterolateral AL bundle footprint on the femur and more centrally in the PCL footprint on the tibia. This study is the first to describe the detailed anatomy of the human PCL with respect to its course and footprints using a 3D approach. It confirms the large difference between the tibial and the femoral footprint area with the former being significantly smaller. In addition, a large inter-patient variability is observed. The best-fit cylinder and central axis concept offer additional insights into the optimal tunnel placement at the tibia and femoral footprint in order to cover the largest portion of the native PCL soft tissue.

Expanding CyberShake Physics-Based Seismic Hazard Calculations to Central California

NASA Astrophysics Data System (ADS)

Silva, F.; Callaghan, S.; Maechling, P. J.; Goulet, C. A.; Milner, K. R.; Graves, R. W.; Olsen, K. B.; Jordan, T. H.

2016-12-01

As part of its program of earthquake system science, the Southern California Earthquake Center (SCEC) has developed a simulation platform, CyberShake, to perform physics-based probabilistic seismic hazard analysis (PSHA) using 3D deterministic wave propagation simulations. CyberShake performs PSHA by first simulating a tensor-valued wavefield of Strain Green Tensors. CyberShake then takes an earthquake rupture forecast and extends it by varying the hypocenter location and slip distribution, resulting in about 500,000 rupture variations. Seismic reciprocity is used to calculate synthetic seismograms for each rupture variation at each computation site. These seismograms are processed to obtain intensity measures, such as spectral acceleration, which are then combined with probabilities from the earthquake rupture forecast to produce a hazard curve. Hazard curves are calculated at seismic frequencies up to 1 Hz for hundreds of sites in a region and the results interpolated to obtain a hazard map. In developing and verifying CyberShake, we have focused our modeling in the greater Los Angeles region. We are now expanding the hazard calculations into Central California. Using workflow tools running jobs across two large-scale open-science supercomputers, NCSA Blue Waters and OLCF Titan, we calculated 1-Hz PSHA results for over 400 locations in Central California. For each location, we produced hazard curves using both a 3D central California velocity model created via tomographic inversion, and a regionally averaged 1D model. These new results provide low-frequency exceedance probabilities for the rapidly expanding metropolitan areas of Santa Barbara, Bakersfield, and San Luis Obispo, and lend new insights into the effects of directivity-basin coupling associated with basins juxtaposed to major faults such as the San Andreas. Particularly interesting are the basin effects associated with the deep sediments of the southern San Joaquin Valley. We will compare hazard estimates from the 1D and 3D models, summarize the challenges of expanding CyberShake to a new geographic region, and describe our future CyberShake plans.

Informatics in radiology: automated Web-based graphical dashboard for radiology operational business intelligence.

PubMed

Nagy, Paul G; Warnock, Max J; Daly, Mark; Toland, Christopher; Meenan, Christopher D; Mezrich, Reuben S

2009-11-01

Radiology departments today are faced with many challenges to improve operational efficiency, performance, and quality. Many organizations rely on antiquated, paper-based methods to review their historical performance and understand their operations. With increased workloads, geographically dispersed image acquisition and reading sites, and rapidly changing technologies, this approach is increasingly untenable. A Web-based dashboard was constructed to automate the extraction, processing, and display of indicators and thereby provide useful and current data for twice-monthly departmental operational meetings. The feasibility of extracting specific metrics from clinical information systems was evaluated as part of a longer-term effort to build a radiology business intelligence architecture. Operational data were extracted from clinical information systems and stored in a centralized data warehouse. Higher-level analytics were performed on the centralized data, a process that generated indicators in a dynamic Web-based graphical environment that proved valuable in discussion and root cause analysis. Results aggregated over a 24-month period since implementation suggest that this operational business intelligence reporting system has provided significant data for driving more effective management decisions to improve productivity, performance, and quality of service in the department.

Use of continuous monitoring to assess stream nitrate flux and transformation patterns.

PubMed

Jones, Christopher; Kim, Sea-Won; Schilling, Keith

2017-01-01

Delivery of nitrogen from farmed fields to the stream network is an ongoing water quality issue in central North America and other parts of the world. Although fertilization and other farming practices have been refined to produce environmental improvements, stemming loss of nitrogen, especially in the soluble nitrate form, is a problem that has seemingly defied solution. The Iowa Nutrient Reduction Strategy is a policy initiative designed to implement conservation and other farm management practices to produce reductions in nitrate loading. The strategy does not focus on how the streams themselves may or may not be processing nitrogen and reducing downstream loading. We used continuous high-frequency nitrate and discharge monitoring over 3 years at two sites separated by 18 km in a low-order, agricultural stream in eastern Iowa to estimate how nitrogen is processed, and whether or not these processes are reducing downstream loading. We conclude that the upstream to downstream nitrate concentration decline between the two sites was not driven by denitrification. These data also show that nitrate concentrations are closely coupled to discharge during periods of adequate moisture, but decoupling of concentration from discharge occurs during dry periods. This decoupling is a possible indicator of in-stream nitrate processing. Finally, nitrate concentrations are likely diluted by water sourced from non-row crop land covers in the lower reaches of the watershed.

ADASS Web Database XML Project

NASA Astrophysics Data System (ADS)

Barg, M. I.; Stobie, E. B.; Ferro, A. J.; O'Neil, E. J.

In the spring of 2000, at the request of the ADASS Program Organizing Committee (POC), we began organizing information from previous ADASS conferences in an effort to create a centralized database. The beginnings of this database originated from data (invited speakers, participants, papers, etc.) extracted from HyperText Markup Language (HTML) documents from past ADASS host sites. Unfortunately, not all HTML documents are well formed and parsing them proved to be an iterative process. It was evident at the beginning that if these Web documents were organized in a standardized way, such as XML (Extensible Markup Language), the processing of this information across the Web could be automated, more efficient, and less error prone. This paper will briefly review the many programming tools available for processing XML, including Java, Perl and Python, and will explore the mapping of relational data from our MySQL database to XML.

Direct observation of TALE protein dynamics reveals a two-state search mechanism.

PubMed

Cuculis, Luke; Abil, Zhanar; Zhao, Huimin; Schroeder, Charles M

2015-06-01

Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins for which the fundamental mechanisms governing the search process are not fully understood. Here we use single-molecule techniques to directly observe TALE search dynamics along DNA templates. We find that TALE proteins are capable of rapid diffusion along DNA using a combination of sliding and hopping behaviour, which suggests that the TALE search process is governed in part by facilitated diffusion. We also observe that TALE proteins exhibit two distinct modes of action during the search process-a search state and a recognition state-facilitated by different subdomains in monomeric TALE proteins. Using TALE truncation mutants, we further demonstrate that the N-terminal region of TALEs is required for the initial non-specific binding and subsequent rapid search along DNA, whereas the central repeat domain is required for transitioning into the site-specific recognition state.

ISO 50001 and SEP Faster and Cheaper - Exploring the Enterprise-Wide Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Jingjing; Rao, Prakash; Therkelsen, Peter

ISO 50001 and other management systems (e.g., ISO 9001 and ISO 14001) allow for implementation and certification at the enterprise level. The "Central Office" concept, which allows a small group of employees to manage and facilitate the organization’s energy management system (EnMS) at the enterprise level, was introduced within the ISO 50003 standard to provide guidance to ISO 50001 certification bodies. Four industrial companies have partnered with the United States Department of Energy to pilot the enterprise-wide ISO 50001/SEP concept under the Better Buildings Superior Energy Performance (SEP) Enterprise-wide Accelerator. Each organization developed a Central Office to host their EnMSmore » while implementing ISO 50001/SEP at multiple physically separated sites. The four corporate partners tailored their Central Office implementation model to meet their own specific circumstances and needs. This paper reviews the commonalities, differences, and benefits of each of these enterprise-wide implementation models, including organizational structures, Central Office staff responsibilities, and key strategies. The cost savings and benefits of using the enterprise-wide approach were assessed, including the cost per site compared with that of a conventional, single-site ISO 50001/SEP implementation approach. This paper also discusses the drivers for the cost reductions realized through these enterprise-wide approaches. The four partner companies worked with 30 total sites. On average, these 30 sites improved energy performance by 5% annually over their SEP achievement periods, saved more than $600,000 annually in energy costs and reduced implementation cost for ISO 50001 and SEP by $19,000 and 0.8 Full Time Equivalent × years (FTE-yr) of staff time per site. The results can inform other organizations seeking to implement enterprise-wide ISO 50001/SEP, as well as energy efficiency organizations seeking to promote wider adoption of ISO 50001 implementation.« less

AmeriFlux US-Br1 Brooks Field Site 10- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br1 Brooks Field Site 10- Ames. Site Description - The Brooks Field Site 10 - Ames Site is one of three sites (Brooks Field Site 11 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

AmeriFlux US-Br3 Brooks Field Site 11- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br3 Brooks Field Site 11- Ames. Site Description - The Brooks Field Site 11 - Ames Site is one of three sites (Brooks Field Site 10 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

Fourteen years of forage monitoring on the California Central Coast shows tremendous variation

Treesearch

Royce Larsen; Karl Striby; Marc Horney

2015-01-01

To better understand forage production (above ground biomass) and precipitation patterns in the Central Coast region of California, the first in a growing network of primary production monitoring sites were established in 2001. The California Central Coast has a Mediterranean climate with cool, moist winters and hot, dry summers, and is dominated by annual grasslands...

Trapezius placement of implanted ports: understanding the procedure.

PubMed

Hill, Steve

Totally implantable vascular access devices (TIVADs) are indicated for intermittent long-term intravenous access. It is widely accepted within medical literature that TIVADs are associated with statistically significant lower infection rates than other central venous access devices. Typical sites for implantation are on the anterior chest wall, using the internal jugular, axillary, cephalic or a subclavian vein. This article follows on from a previous discussion of the benefits of this approach, which illustrated and examined clinical outcomes of trapezius-placement versus anterior chest wall placed ports, for patients with metastatic subcutaneous disease on the anterior chest wall. The procedure provides a unique challenge for the clinician. This article focuses on the process of trapezius port implantation, providing an illustrative guide to understand the procedure. Trapezius port placement is a viable option for patients for whom routine sites are excluded and who require long-term intermittent vascular access.

Visual evoked potentials and selective attention to points in space

NASA Technical Reports Server (NTRS)

Van Voorhis, S.; Hillyard, S. A.

1977-01-01

Visual evoked potentials (VEPs) were recorded to sequences of flashes delivered to the right and left visual fields while subjects responded promptly to designated stimuli in one field at a time (focused attention), in both fields at once (divided attention), or to neither field (passive). Three stimulus schedules were used: the first was a replication of a previous study (Eason, Harter, and White, 1969) where left- and right-field flashes were delivered quasi-independently, while in the other two the flashes were delivered to the two fields in random order (Bernoulli sequence). VEPs to attended-field stimuli were enhanced at both occipital (O2) and central (Cz) recording sites under all stimulus sequences, but different components were affected at the two scalp sites. It was suggested that the VEP at O2 may reflect modality-specific processing events, while the response at Cz, like its auditory homologue, may index more general aspects of selective attention.

First experience with Remote Sensing methods and selected sensors in the monitoring of mining areas - a case study of the Belchatow open cast mine

NASA Astrophysics Data System (ADS)

Wajs, Jaroslaw

2018-01-01

The paper presents satellite imagery from active SENTINEL-1A and passive SENTINEL-2A/2B sensors for their application in the monitoring of mining areas focused on detecting land changes. Multispectral scenes of SENTINEL-2A/2B have allowed for detecting changes in land-cover near the region of interest (ROI), i.e. the Szczercow dumping site in the Belchatow open cast lignite mine, central Poland, Europe. Scenes from SENTINEL-1A/1B satellite have also been used in the research. Processing of the SLC signal enabled creating a return intensity map in VV polarization. The obtained SAR scene was reclassified and shows a strong return signal from the dumping site and the open pit. This fact may be used in detection and monitoring of changes occurring within the analysed engineering objects.

Enumeration of major peripheral blood leukocyte populations for multicenter clinical trials using a whole blood phenotyping assay.

PubMed

Hensley, Tiffany R; Easter, Austin B; Gerdts, Sarah E; De Rosa, Stephen C; Heit, Antje; McElrath, M Juliana; Andersen-Nissen, Erica

2012-09-16

Cryopreservation of peripheral blood leukocytes is widely used to preserve cells for immune response evaluations in clinical trials and offers many advantages for ease and standardization of immunological assessments, but detrimental effects of this process have been observed on some cell subsets, such as granulocytes, B cells, and dendritic cells. Assaying fresh leukocytes gives a more accurate picture of the in vivo state of the cells, but is often difficult to perform in the context of large clinical trials. Fresh cell assays are dependent upon volunteer commitments and timeframes and, if time-consuming, their application can be impractical due to the working hours required of laboratory personnel. In addition, when trials are conducted at multiple centers, laboratories with the resources and training necessary to perform the assays may not be located in sufficient proximity to clinical sites. To address these issues, we have developed an 11-color antibody staining panel that can be used with Trucount tubes (Becton Dickinson; San Jose, CA) to phenotype and enumerate the major leukocyte populations within the peripheral blood, yielding more robust cell-type specific information than assays such as a complete blood count (CBC) or assays with commercially-available panels designed for Trucount tubes that stain for only a few cell types. The staining procedure is simple, requires only 100 μl of fresh whole blood, and takes approximately 45 minutes, making it feasible for standard blood-processing labs to perform. It is adapted from the BD Trucount tube technical data sheet (version 8/2010). The staining antibody cocktail can be prepared in advance in bulk at a central assay laboratory and shipped to the site processing labs. Stained tubes can be fixed and frozen for shipment to the central assay laboratory for multicolor flow cytometry analysis. The data generated from this staining panel can be used to track changes in leukocyte concentrations over time in relation to intervention and could easily be further developed to assess activation states of specific cell types of interest. In this report, we demonstrate the procedure used by blood-processing lab technicians to perform staining on fresh whole blood and the steps to analyze these stained samples at a central assay laboratory supporting a multicenter clinical trial. The video details the procedure as it is performed in the context of a clinical trial blood draw in the HIV Vaccine Trials Network (HVTN).

Magnetic Fields of Lunar Impact Basins and Their Use in Constraining the Impact Process

NASA Astrophysics Data System (ADS)

Halekas, J. S.; Lin, R. P.

2003-01-01

Measurements by the Magnetometer/Electron Reflectometer instrument on the Lunar Prospector spacecraft, which completed its mapping mission in 1999, have been used to construct the first completely global maps of lunar crustal magnetic fields. Now, for the first time, we have a data set with global coverage and a sensitivity and resolution which allow us to investigate the magnetic fields of lunar impact basins and craters. As on the Earth, impact sites have a variety of magnetic signatures associated with them, ranging from nearly complete demagnetization to strong central magnetic anomalies. Observations of the magnetic fields of terrestrial basins have been used to make inferences about the impact process, and we wish to show that lunar observations can also provide valuable constraints.

How Should Beta-Diversity Inform Biodiversity Conservation?

PubMed

Socolar, Jacob B; Gilroy, James J; Kunin, William E; Edwards, David P

2016-01-01

To design robust protected area networks, accurately measure species losses, or understand the processes that maintain species diversity, conservation science must consider the organization of biodiversity in space. Central is beta-diversity--the component of regional diversity that accumulates from compositional differences between local species assemblages. We review how beta-diversity is impacted by human activities, including farming, selective logging, urbanization, species invasions, overhunting, and climate change. Beta-diversity increases, decreases, or remains unchanged by these impacts, depending on the balance of processes that cause species composition to become more different (biotic heterogenization) or more similar (biotic homogenization) between sites. While maintaining high beta-diversity is not always a desirable conservation outcome, understanding beta-diversity is essential for protecting regional diversity and can directly assist conservation planning. Copyright © 2015 Elsevier Ltd. All rights reserved.

Method and system for spatially variable rate application of agricultural chemicals based on remotely sensed vegetation data

NASA Technical Reports Server (NTRS)

Lewis, Mark David (Inventor); Seal, Michael R. (Inventor); Hood, Kenneth Brown (Inventor); Johnson, James William (Inventor)

2007-01-01

Remotely sensed spectral image data are used to develop a Vegetation Index file which represents spatial variations of actual crop vigor throughout a field that is under cultivation. The latter information is processed to place it in a format that can be used by farm personnel to correlate and calibrate it with actually observed crop conditions existing at control points within the field. Based on the results, farm personnel formulate a prescription request, which is forwarded via email or FTP to a central processing site, where the prescription is prepared. The latter is returned via email or FTP to on-side farm personnel, who can load it into a controller on a spray rig that directly applies inputs to the field at a spatially variable rate.

Method and apparatus for spatially variable rate application of agricultural chemicals based on remotely sensed vegetation data

NASA Technical Reports Server (NTRS)

Hood, Kenneth Brown (Inventor); Johnson, James William (Inventor); Seal, Michael R. (Inventor); Lewis, Mark David (Inventor)

2004-01-01

Remotely sensed spectral image data are used to develop a Vegetation Index file which represents spatial variations of actual crop vigor throughout a field that is under cultivation. The latter information is processed to place it in a format that can be used by farm personnel to correlate and calibrate it with actually observed crop conditions existing at control points within the field. Based on the results, farm personnel formulate a prescription request, which is forwarded via email or FTP to a central processing site, where the prescription is prepared. The latter is returned via email or FTP to on-side farm personnel, who can load it into a controller on a spray rig that directly applies inputs to the field at a spatially variable rate.

Atmospheric Radiation Measurement Program Climate Research Facility Operations Quarterly Report. October 1 - December 31, 2009.

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. L. Sisterson

2010-01-12

Individual raw data streams from instrumentation at the Atmospheric Radiation Measurement (ARM) Program Climate Research Facility (ACRF) fixed and mobile sites are collected and sent to the Data Management Facility (DMF) at Pacific Northwest National Laboratory (PNNL) for processing in near real-time. Raw and processed data are then sent approximately daily to the ACRF Archive, where they are made available to users. For each instrument, we calculate the ratio of the actual number of data records received daily at the Archive to the expected number of data records. The results are tabulated by (1) individual data stream, site, and monthmore » for the current year and (2) site and fiscal year (FY) dating back to 1998. The U.S. Department of Energy (DOE) requires national user facilities to report time-based operating data. The requirements concern the actual hours of operation (ACTUAL); the estimated maximum operation or uptime goal (OPSMAX), which accounts for planned downtime; and the VARIANCE [1 - (ACTUAL/OPSMAX)], which accounts for unplanned downtime. The OPSMAX time for the first quarter of FY 2010 for the North Slope Alaska (NSA) locale is 1,987.20 hours (0.90 x 2,208); for the Southern Great Plains (SGP) site is 2,097.60 hours (0.95 x 2,208); and for the Tropical Western Pacific (TWP) locale is 1,876.8 hours (0.85 x 2,208). The ARM Mobile Facility (AMF) deployment in Graciosa Island, the Azores, Portugal, continues; its OPSMAX time this quarter is 2,097.60 hours (0.95 x 2,208). The differences in OPSMAX performance reflect the complexity of local logistics and the frequency of extreme weather events. It is impractical to measure OPSMAX for each instrument or data stream. Data availability reported here refers to the average of the individual, continuous data streams that have been received by the Archive. Data not at the Archive are the result of downtime (scheduled or unplanned) of the individual instruments. Therefore, data availability is directly related to individual instrument uptime. Thus, the average percentage of data in the Archive represents the average percentage of the time (24 hours per day, 92 days for this quarter) the instruments were operating this quarter. The Site Access Request System is a web-based database used to track visitors to the fixed and mobile sites, all of which have facilities that can be visited. The NSA locale has the Barrow and Atqasuk sites. The SGP locale has historically had a central facility, 23 extended facilities, 4 boundary facilities, and 3 intermediate facilities. Beginning this quarter, the SGP began a transition to a smaller footprint (150 km x 150 km) by rearranging the original and new instrumentation made available through the American Recovery and Reinvestment Act (ARRA). The central facility and 4 extended facilities will remain, but there will be up to 16 surface new characterization facilities, 4 radar facilities, and 3 profiler facilities sited in the smaller domain. This new configuration will provide observations at scales more appropriate to current and future climate models. The TWP locale has the Manus, Nauru, and Darwin sites. These sites will also have expanded measurement capabilities with the addition of new instrumentation made available through ARRA funds. It is anticipated that the new instrumentation at all the fixed sites will be in place within the next 12 months. The AMF continues its 20-month deployment in Graciosa Island, Azores, Portugal, that started May 1, 2009. The AMF will also have additional observational capabilities within the next 12 months. Users can participate in field experiments at the sites and mobile facility, or they can participate remotely. Therefore, a variety of mechanisms are provided to users to access site information. Users who have immediate (real-time) needs for data access can request a research account on the local site data systems. This access is particularly useful to users for quick decisions in executing time-dependent activities associated with field campaigns at the fixed sites and mobile facility locations. The eight computers for the research accounts are located at the Barrow and Atqasuk sites; the SGP central facility; the TWP Manus, Nauru, and Darwin sites; the AMF; and the DMF at PNNL. However, users are warned that the data provided at the time of collection have not been fully screened for quality and therefore are not considered to be official ACRF data. Hence, these accounts are considered to be part of the facility activities associated with field campaign activities, and users are tracked. In addition, users who visit sites can connect their computer or instrument to an ACRF site data system network, which requires an on-site device account. Remote (off-site) users can also have remote access to any ACRF instrument or computer system at any ACRF site, which requires an off-site device account. These accounts are also managed and tracked.« less

Carbon Emission from Forest Fires on Scots Pine Logging Sites in the Angara Region of Central Siberia

NASA Astrophysics Data System (ADS)

Ivanova, G. A.; Conard, S. G.; McRae, D. J.; Kukavskaya, E. A.; Bogorodskaya, A. V.; Kovaleva, N. M.

2010-12-01

Wildfire and large-scale forest harvesting are the two major disturbances in the Russian boreal forests. Non-recovered logged sites total about a million hectares in Siberia. Logged sites are characterized by higher fire hazard than forest sites due to the presence of generally untreated logging slash (i.e., available fuel) which dries out much more rapidly compared to understory fuels. Moreover, most logging sites can be easily accessed by local population; this increases the risk for fire ignition. Fire impacts on the overstory trees, subcanopy woody layer, and ground vegetation biomass were estimated on 14 logged and unlogged comparison sites in the Lower Angara Region in 2009-2010 as part of the NASA-funded NEESPI project, The Influence of Changing Forestry Practices on the Effects of Wildfire and on Interactions Between Fire and Changing Climate in Central Siberia. Based on calculated fuel consumption, we estimated carbon emission from fires on both logged and unlogged burned sites. Carbon emission from fires on logged sites appeared to be twice that on unlogged sites. Soil respiration decreased on both site types after fires. This reduction may partially offset fire-produced carbon emissions. Carbon emissions from fire and post-fire ecosystem damage on logged sites are expected to increase under changing climate conditions and as a result of anticipated increases in future forest harvesting in Siberia.