Why we need a centralized repository for isotopic data

USDA-ARS?s Scientific Manuscript database

Stable isotopes encode the origin and integrate the history of matter; thus, their analysis offers tremendous potential to address questions across diverse scientific disciplines. Indeed, the broad applicability of stable isotopes, coupled with advancements in high-throughput analysis, have created ...

Medication education and consultation at a senior dining program for independently living seniors.

PubMed

Schmiedt, Dean; Ellingson, Jody

2010-08-01

To determine if pharmacist involvement within a senior dining program benefits diners by addressing their medication-related questions, using educational sessions, and providing individual consultations. Catholic Charities Senior Dining sites in central Minnesota. Pharmacists went to three senior dining sites, providing educational sessions and individual consultations to independently living senior diners. Pharmacists developed a program, in a nontraditional setting, that used educational sessions and individual consultations to assist seniors with their medication-related questions. The number of diner questions, significant issues raised, issues addressed, and level of diner satisfaction. Pharmacists made 36 visits from January to December 2009. During those visits they presented educational talks to 3,089 diners, and 12.4% of all diners spoke individually with pharmacists. Pharmacists addressed 581 questions or concerns from 384 diners. Significant issues were noted in 25.8% of individual consultations (144 questions). The most common significant issues included: adverse drug reactions (59), indications without treatment (27), and drug interactions (23). Nonopioid analgesics, antilipemics, and antihypertensive medications were most commonly involved in significant issues. Satisfaction surveys were strongly positive, with 97% indicating pharmacists had addressed their medication-related concern; only 3% did not reply. Almost half (42.7%) of satisfaction surveys indicated the diner would change something as a result of meeting with the pharmacist. Pharmacist availability in a nontraditional setting can assist seniors with addressing potentially significant medication-related issues. Independently living seniors will seek out information from a pharmacist in a convenient setting.

An Interview with Ilan Stavans

ERIC Educational Resources Information Center

Prado, Jose

2007-01-01

This interview with Ilan Stavans addresses central experiences tied to the educational and immigrant experiences of Latinos in the United States. Culture, immigration, assimilation, and language are the prisms through which this experience is understood. Ilan Stavans responds to questions concerning cultural heterogeneity and cultural homogeneity.…

Autonomic responses to exercise: where is central command?

PubMed

Williamson, J W

2015-03-01

A central command is thought to involve a signal arising in a central area of the brain eliciting a parallel activation of the autonomic nervous system and skeletal muscle contraction during exercise. Although much of the neural circuitry involved in autonomic control has been identified, defining the specific higher brain region(s) serving in a central command capacity has proven more challenging. Investigators have been faced with redundancies in regulatory systems, feedback mechanisms and the complexities ofhuman neural connectivity. Several studies have attempted to address these issues and provide more definitive neuroanatomical information. However, none have clearly answered the question, "where is central command?" Copyright © 2014 Elsevier B.V. All rights reserved.

Preferences for Inequality: East vs. West. Innocenti Working Papers.

ERIC Educational Resources Information Center

Suhrcke, Marc

Do preferences for income inequality differ systematically between the post-socialist countries of central and eastern Europe and the western established market economies? Analyzing 1999 data from a large international survey to address this question, the paper examines whether attitudes to inequality differ between east and west even after the…

A Three Year Follow-Up of a Preschool Intervention Program.

ERIC Educational Resources Information Center

Hendrix, Sandra; Dokecki, Paul R.

This research addressed the question of how preschool experiences will be reflected in later development. Both cognitive functioning and social behavioral adjustment were explored. The central focus was on attitudes conducive to achievement which The Demonstration and Research Center for Early Education (DARCEE) preschool program sought to develop…

Encoding, Memory, and Transcoding Deficits in Childhood Apraxia of Speech

ERIC Educational Resources Information Center

Shriberg, Lawrence D.; Lohmeier, Heather L.; Strand, Edythe A.; Jakielski, Kathy J.

2012-01-01

A central question in Childhood Apraxia of Speech (CAS) is whether the core phenotype is limited to transcoding (planning/programming) deficits or if speakers with CAS also have deficits in auditory-perceptual "encoding" (representational) and/or "memory" (storage and retrieval of representations) processes. We addressed this and other questions…

WORKSHOP TO IDENTIFY CRITICAL WINDOWS OF EXPOSURE FOR CHILDREN'S HEALTH: REPRODUCTIVE HEALTH IN CHILDREN AND ADOLESCENTS WORK GROUP SUMMARY

EPA Science Inventory

This workgroup report addresses the central question: what are the critical windows during development (pre-conception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health. The reproductive system develops in stages...

At Issue: Academic Integrity, an Annotated Bibliography

ERIC Educational Resources Information Center

Pricer, Wayne F.

2009-01-01

Academic integrity is central to the heart of any academic institution, yet the topic is a complex one. This bibliography addresses the subjects of copyright and plagiarism. Resources for exploring common campus copyright and fair use issues seek to answer common, frequently misunderstood questions such as what exactly does "copyright" mean? What…

Adolescent Literacies in a Multicultural Context. Routledge Research in Education

ERIC Educational Resources Information Center

Cumming, Alister, Ed.

2012-01-01

This book presents results from a four-year project addressing the central question: What factors, challenges, and contexts contribute to and constrain literacy achievement among at-risk adolescent learners with culturally diverse backgrounds? Researchers consider the importance of several, interrelated factors that support the development of…

Features of globular cluster's dynamics with an intermediate-mass black hole

NASA Astrophysics Data System (ADS)

Ryabova, Marina V.; Gorban, Alena S.; Shchekinov, Yuri A.; Vasiliev, Evgenii O.

2018-02-01

In this paper, we address the question of how a central intermediate-mass black hole (IMBH) in a globular cluster (GC) affects dynamics, core collapse, and formation of the binary population. It is shown that the central IMBH forms a binary system that affects dynamics of stars in the cluster significantly. The presence of an intermediate-mass black hole with mass ≥ 1.0-1.7%of the total stellar mass in the cluster inhibits the formation of binary stars population.

What's in a name: what analyst and patient call each other.

PubMed

Barron, Grace Caroline

2006-01-01

Awkward moments often arise between patient and analyst involving the question, "What do we call each other?" The manner in which the dyad address each other contains material central to the patient's inner life. Names, like dreams, deserve a privileged status as providing a royal road into the paradoxical analytic relationship and the unconscious conflicts that feed it. Whether an analyst addresses the patient formally, informally, or not at all, awareness of the issues surrounding names is important.

The influence of a central vacuum system on quality life in patients with house dust-associated allergic rhinitis.

PubMed

Naguwa, S M; Gershwin, M E

2001-01-01

Indoor pollution is one of the most common problems addressed by allergists and troublesome for their patients. Although a large variety of products are available for removing such pollutants, including house dust, there is a relative paucity of data on the effectiveness of such devices. In many cases, central vacuum systems are recommended, particularly in new homes. To specifically address the question of whether a central vacuum system produces an improvement in the well characterized domains of Juniper Rhinoconjunctivitis Quality of Life Questionnaire, we selected 25 individuals with a history of documented type I hypersensitivity to house dust. Each of these individuals used either a Beam Central Vacuum System or their own conventional vacuum for a period of 3 months. At the end of this period, the individual switched over to the opposite limb of the study for 3 additional months. Interestingly, in all seven domains of the evaluation, including activity, sleep, nonnasal symptoms, practical problems, nasal symptoms, eye symptoms and emotions, use of the central vacuum proved to be superior.

Cooperation in the Classroom: Students and Teachers Together. Analysis and Action Series. Second Edition.

ERIC Educational Resources Information Center

Cangelosi, James S.

The central question addressed by this book is, "How can middle and secondary school teachers overcome seemingly impossible circumstances in the classroom and elicit students' attention, effort, and cooperation?" The first five chapters focus on teachers' responsibility for student's classroom behavior, and ways for teachers to manage…

From Prejudice to Reasonable Judgement: Integrating (Moral) Value Discussions in University Courses

ERIC Educational Resources Information Center

Aalberts, Joyce; Koster, Edwin; Boschhuizen, Robert

2012-01-01

The central question addressed in this article is how (moral) values discussions in university courses can be integrated in a systematic way. Discussion of (moral) values is fundamental to the Dublin descriptor about judgement formation in use in European universities. To integrate this descriptor and its (moral) values aspects in university…

Community Destruction and Traumatic Stress in Post-Tsunami Indonesia

ERIC Educational Resources Information Center

Frankenberg, Elizabeth; Nobles, Jenna; Sumantri, Cecep

2012-01-01

How are individuals affected when the communities they live in change for the worse? This question is central to understanding neighborhood effects, but few study designs generate estimates that can be interpreted causally. We address issues of inference through a natural experiment, examining post-traumatic stress at multiple time points in a…

Additional Support Needs Policy in Scotland: Challenging or Reinforcing Social Inequality?

ERIC Educational Resources Information Center

Riddell, Sheila; Weedon, Elisabet

2016-01-01

This paper focuses on Scottish policy on additional support needs and its material outcomes. The central question addressed is the extent to which the Scottish additional support needs system undermines or reinforces existing social and economic inequalities. Administrative data highlight the inflation of the additional support needs category,…

Educating the Democratic Mind. SUNY Series, Democracy and Education.

ERIC Educational Resources Information Center

Parker, Walter C., Ed.

This volume features 16 essays about educating young people for the amorphous state called democracy. The collections addresses the central questions: (1) How and what might children be taught so that they respond well and creatively to the demands of an increasingly diverse society that is organized under and struggling to realize the democratic…

Creating a Whole School Ethos of Care

ERIC Educational Resources Information Center

Warin, Jo

2017-01-01

This paper raises questions about schools as positive models of caring societies. Against a background of growing concern for the mental health of children it addresses the centrality of "nurture" and its close cousin "care" as a whole school value, theorised as both a means and an end of schooling. How might school leaders…

What Kind of Citizenship for European Higher Education? Beyond the Competent Active Citizen

ERIC Educational Resources Information Center

Biesta, Gert

2009-01-01

How might European higher education contribute to the promotion and development of European citizenship? In this article, the author addresses this question through a critical discussion of the notions of "active citizenship" and "civic competence", which play a central role in current policy and research on the role of…

Identifying and addressing contemporary issues in central coast oak woodlands

Treesearch

Erin Rice; Doug Piirto; Royce Larsen; Bill Tietje; Ryan Cooper; Ulric Lund

2008-01-01

Recently, questions about the extent of thinning, the sustainability of forest management practices, and the compatibility with other uses were raised by the media, agency personnel, and environmental groups. In response, University of California Cooperative Extension and Cal Poly San Luis Obispo’s Natural Resources Management Department collaborated to...

3D Inhabited Virtual Worlds: Interactivity and Interaction between Avatars, Autonomous Agents, and Users.

ERIC Educational Resources Information Center

Jensen, Jens F.

This paper addresses some of the central questions currently related to 3-Dimensional Inhabited Virtual Worlds (3D-IVWs), their virtual interactions, and communication, drawing from the theory and methodology of sociology, interaction analysis, interpersonal communication, semiotics, cultural studies, and media studies. First, 3D-IVWs--seen as a…

The Endpoint Hypothesis: A Topological-Cognitive Assessment of Geographic Scale Movement Patterns

NASA Astrophysics Data System (ADS)

Klippel, Alexander; Li, Rui

Movement patterns of individual entities at the geographic scale are becoming a prominent research focus in spatial sciences. One pertinent question is how cognitive and formal characterizations of movement patterns relate. In other words, are (mostly qualitative) formal characterizations cognitively adequate? This article experimentally evaluates movement patterns that can be characterized as paths through a conceptual neighborhood graph, that is, two extended spatial entities changing their topological relationship gradually. The central questions addressed are: (a) Do humans naturally use topology to create cognitive equivalent classes, that is, is topology the basis for categorizing movement patterns spatially? (b) Are ‘all’ topological relations equally salient, and (c) does language influence categorization. The first two questions are addressed using a modification of the endpoint hypothesis stating that: movement patterns are distinguished by the topological relation they end in. The third question addresses whether language has an influence on the classification of movement patterns, that is, whether there is a difference between linguistic and non-linguistic category construction. In contrast to our previous findings we were able to document the importance of topology for conceptualizing movement patterns but also reveal differences in the cognitive saliency of topological relations. The latter aspect calls for a weighted conceptual neighborhood graph to cognitively adequately model human conceptualization processes.

The Impact of Credit-Based Transition Programs on Changing the Educational Aspirations of High School Seniors

ERIC Educational Resources Information Center

Howerter, Wendy Lou

2011-01-01

This correlational study samples twelfth grade (senior) students in one central Midwest high school and examines their participation in credit-based transition programs and their changes in educational aspirations. Surveys and community college data are used to collect quantitative data to address six research questions. Using Hossler and…

Identifying Culturally Competent Clinical Skills in Speech-Language Pathologists in the Central Valley of California

ERIC Educational Resources Information Center

Maul, Christine A.

2010-01-01

The purpose of this research was to identify specific clinical skills in speech-language pathologists (SLPs) that may constitute cultural competency, a term which currently lacks operational definition. Through qualitative interview methods, the following research questions were addressed: (1) What dominant themes, if any, can be found in SLPs'…

A Meta-Analysis of the RTI Literature for Children at Risk for Reading Disabilities

ERIC Educational Resources Information Center

Tran, Loan; Sanchez, Tori; Arellano, Brenda; Swanson, H. Lee

2011-01-01

This article synthesizes the literature comparing at-risk children designated as responders and low responders to interventions in reading. The central question addressed in this review is whether individual differences in reading-related skills at pretest predict responders at posttest across a variety of interventions and sets of criteria for…

Rethinking Teaching and Learning Mathematics for Social Justice from a Critical Race Perspective

ERIC Educational Resources Information Center

Larnell, Gregory V.; Bullock, Erika C.; Jett, Christopher C.

2016-01-01

What is teaching and learning mathematics for social justice (TLMSJ)? How has TLMSJ been taken up in mathematics education--both historically and contemporarily? Along with unpacking these two central questions, this article assesses the current capacity and stance of TLMSJ toward addressing issues of racial injustice. The authors begin with an…

Early Instruction in Geography: An Exploration in the Ecology of Kindergarten and First-Grade Geography Education

ERIC Educational Resources Information Center

Walker, Scott L.

2007-01-01

This article presents an introductory study of early-grade level geography education in terms of human ecology using accepted cognitive process and knowledge dimensions related to learning. The central question addressed is "at what cognitive process and knowledge levels do kindergarten and first-grade teachers teach geography?" A tentative answer…

Comparing Children's Performance on and Preference for a Number-Line Estimation Task: Tablet versus Paper and Pencil

ERIC Educational Resources Information Center

Piatt, Carley; Coret, Marian; Choi, Michael; Volden, Joanne; Bisanz, Jeffrey

2016-01-01

Tablet computers (tablets) are positioned to be powerful, innovative, effective, and motivating research and assessment tools. We addressed two questions critical for evaluating the appropriateness of using tablets to study number-line estimation, a skill associated with math achievement and argued to be central to numerical cognition. First, is…

What It Feels Like to Be a Mother: Variations by Children's Developmental Stages

ERIC Educational Resources Information Center

Luthar, Suniya S.; Ciciolla, Lucia

2016-01-01

The central question we addressed was whether mothers' adjustment might vary systematically by the developmental stages of their children. In an Internet-based study of over 2,200 mostly well-educated mothers with children ranging from infants to adults, we examined multiple aspects of mothers' personal well-being, parenting, and perceptions of…

A Narrative Inquiry of Latina/o Teachers in Urban Elementary Schools

ERIC Educational Resources Information Center

Hernandez-Scott, Erica

2017-01-01

Latina/o teachers are underrepresented in the educational workforce. As such, the purpose of this narrative inquiry is to explore the experiences of Latinas/os who are teaching in urban school districts. The central question addressed by this narrative inquiry was: "To what do Latina/o teachers attribute to their academic and career…

Working without Shame in International Educational Development? From Consequentialism to Casuistry

ERIC Educational Resources Information Center

Bridges, David

2015-01-01

The central question addressed in this paper is about the ethics of engaging with educational development in countries perceived as undemocratic or as failing to respect human rights. More particularly, it examines the nature of the arguments that are brought to bear on this issue. It suggests that these are essentially consequentialist in…

The Longitudinal Interplay of Adolescents' Self-Esteem and Body Image: A Conditional Autoregressive Latent Trajectory Analysis

ERIC Educational Resources Information Center

Morin, Alexandre J. S.; Maiano, Christophe; Marsh, Herbert W.; Janosz, Michel; Nagengast, Benjamin

2011-01-01

Self-esteem and body image are central to coping successfully with the developmental challenges of adolescence. However, the current knowledge surrounding self-esteem and body image is fraught with controversy. This study attempts to clarify some of them by addressing three questions: (1) Are the intraindividual developmental trajectories of…

Exploring Public Relations Excellence and Integrated Marketing Communications at Private, Nonprofit Higher Education Institutions

ERIC Educational Resources Information Center

Higgins, Shannon K.

2017-01-01

Purpose: Many recent articles discuss the increased marketization of higher education, but few examine whether such practices are executed at their optimum level of efficiency and efficacy. This study addressed the significant lack of research in this area and answers the central question of how optimally public relations and marketing departments…

Transcription Matters: Transcribing Talk and Interaction to Facilitate Conversation Analysis of the Taken-for-Granted in Young Children's Interactions

ERIC Educational Resources Information Center

Davidson, Christina

2010-01-01

The development of transcripts is central to the work of many researchers yet questions of what and how researchers transcribe, and why, receive little attention in research literature. Conversation analysis is one research approach that has consistently addressed the integral relationship between theoretical and methodological perspectives,…

Understanding independence

NASA Astrophysics Data System (ADS)

Annan, James; Hargreaves, Julia

2016-04-01

In order to perform any Bayesian processing of a model ensemble, we need a prior over the ensemble members. In the case of multimodel ensembles such as CMIP, the historical approach of ``model democracy'' (i.e. equal weight for all models in the sample) is no longer credible (if it ever was) due to model duplication and inbreeding. The question of ``model independence'' is central to the question of prior weights. However, although this question has been repeatedly raised, it has not yet been satisfactorily addressed. Here I will discuss the issue of independence and present a theoretical foundation for understanding and analysing the ensemble in this context. I will also present some simple examples showing how these ideas may be applied and developed.

Using Dimensional Data to Address Enrollment Management Questions in Higher Education

ERIC Educational Resources Information Center

Duniway, Bob; Wiegand, Karl

2009-01-01

Enrollment management is central to the success of a college or university. A school must enroll students into courses, completion of a series of which will lead to graduation. While all colleges and universities must manage the enrollment process at least operationally, it is challenging to keep track of all the related data that would allow for…

How Is the Serial Order of a Visual Sequence Represented? Insights from Transposition Latencies

ERIC Educational Resources Information Center

Hurlstone, Mark J.; Hitch, Graham J.

2018-01-01

A central goal of research on short-term memory (STM) over the past 2 decades has been to identify the mechanisms that underpin the representation of serial order, and to establish whether these mechanisms are the same across different modalities and domains (e.g., verbal, visual, spatial). A fruitful approach to addressing this question has…

On Developing Independent Critical Thinking: What We Can Learn from Studies of the Research Process.

ERIC Educational Resources Information Center

Stotsky, Sandra

1991-01-01

Examines studies of what students do as they select and narrow a topic, locate sources, sift through these sources, and develop a central research question or thesis statement. Notes limitations of a related body of research focusing on other kinds of academic writing. Raises conceptual and methodological issues for researchers to address in…

Affordances of Web 2.0 Technologies for Collaborative Advanced Writing in a Foreign Language

ERIC Educational Resources Information Center

Strobl. Carola

2014-01-01

Can online collaboration yield a positive effect on academic writing in a foreign language? If so, what exactly is the added value, compared to individual writing, and (how) does it translate to better output? These are the central questions addressed in this paper. L2 writing research has long highlighted the benefits of collaboration in terms of…

Homelessness in America: What Should We Do? Public Talk Series.

ERIC Educational Resources Information Center

Niedergang, Mark; McCoy, Martha, Ed.

This program guide provides a forum for discussing the different beliefs that influence public policy about homelessness as well as policy goals. The central question is addressed in two parts: (1) what society ought to do for homeless people; and (2) laying out a range of possible answers for part 1. Four possible answers are discussed: help only…

Teaching New Words to Children with Poor Existing Vocabulary Knowledge: A Controlled Evaluation of the Definition and Context Methods

ERIC Educational Resources Information Center

Nash, Hannah; Snowling, Margaret

2006-01-01

Background: Children who have poor vocabulary knowledge are at risk of wider language weaknesses and reading comprehension difficulties, which will impact upon their educational achievement. The central question addressed in this paper is how best to teach new vocabulary items to these children. Aims: To investigate the effects of two different…

Leading for Social Justice: A Project Addressing the Guidance Provided to Superintendents and Principals in the State of Missouri

ERIC Educational Resources Information Center

Pettit, Todd A.

2014-01-01

This report describes a problem-based learning project focusing on the guidance received by superintendents and principals in Missouri public schools in regard to ensuring social justice for all students. Four groups of students emerged as the central focus of this project: lesbian, gay, bisexual, transgender, and questioning (LGBTQ), gender,…

Opinion: Why we need a centralized repository for isotopic data

USGS Publications Warehouse

Pauli, Jonathan N.; Newsome, Seth D.; Cook, Joseph A.; Harrod, Chris; Steffan, Shawn A.; Baker, Christopher J. O.; Ben-David, Merav; Bloom, David; Bowen, Gabriel J.; Cerling, Thure E.; Cicero, Carla; Cook, Craig; Dohm, Michelle; Dharampal, Prarthana S.; Graves, Gary; Gropp, Robert; Hobson, Keith A.; Jordan, Chris; MacFadden, Bruce; Pilaar Birch, Suzanne; Poelen, Jorrit; Ratnasingham, Sujeevan; Russell, Laura; Stricker, Craig A.; Uhen, Mark D.; Yarnes, Christopher T.; Hayden, Brian

2017-01-01

Stable isotopes encode and integrate the origin of matter; thus, their analysis offers tremendous potential to address questions across diverse scientific disciplines (1, 2). Indeed, the broad applicability of stable isotopes, coupled with advancements in high-throughput analysis, have created a scientific field that is growing exponentially, and generating data at a rate paralleling the explosive rise of DNA sequencing and genomics (3). Centralized data repositories, such as GenBank, have become increasingly important as a means for archiving information, and “Big Data” analytics of these resources are revolutionizing science and everyday life.

Metacognitive Analysis of Pre-Service Teachers of Chemistry in Posting Questions

NASA Astrophysics Data System (ADS)

Santoso, T.; Yuanita, L.

2017-04-01

Questions addressed to something can induce metacognitive function to monitor a person’s thinking process. This study aims to describe the structure of the level of student questions based on thinking level and chemistry understanding level and describe how students use their metacognitive knowledge in asking. This research is a case study in chemistry learning, followed by 87 students. Results of the analysis revealed that the structure of thinking level of student question consists of knowledge question, understanding and application question, and high thinking question; the structure of chemistry understanding levels of student questions are a symbol, macro, macro-micro, macro-process, micro-process, and the macro-micro-process. The level Questioning skill of students to scientific articles more qualified than the level questioning skills of students to the teaching materials. The analysis result of six student interviews, a student question demonstrate the metacognitive processes with categories: (1) low-level metacognitive process, which is compiled based on questions focusing on a particular phrase or change the words; (2) intermediate level metacognitive process, submission of questions requires knowledge and understanding, and (3) high-level metacognitive process, the student questions posed based on identifying the central topic or abstraction essence of scientific articles.

Acetylcholinesterase Chirality and Cellular Mechanisms of Organophosphonate Toxicity

DTIC Science & Technology

1990-06-11

toxin bind- FIG. 4. Decidium modulation of [’H]PCP binding to the Tor- ing. To address this question, we examined the concentration pedo membranes...increasing concen- pedo membranes. Here, meproadifen enhances carbamylcho- trations of decidium displace [3H]PCP, consistent with direct line...central a 2-adrenoceptors in the long lasting vasodepression elicited by the organophosphates was considered. Materials and Methods Cats of both sexes

European Higher Education, the Inclusion of Students from Under-Represented Groups and the Bologna Process

ERIC Educational Resources Information Center

Riddell, Sheila; Weedon, Elisabet

2014-01-01

The central questions addressed in this paper are the following: (1) In the context of the (European Union) EU's goal of severing the link between social class background and higher education participation, what progress has been made in widening access over the past two decades? (2) Has the Open Method of Coordination (OMC) helped EU countries to…

Selected Readings in Drama and Theatre Education: The IDEA '95 Papers (2nd, Brisbane, Australia, July 1995). NADIE Research Monograph Series, 3.

ERIC Educational Resources Information Center

Taylor, Philip, Ed.; Hoepper, Christine, Ed.

Documenting some of the myriad of voices assembled in Brisbane, Australia in July 1995 for the Second World Congress of the International Drama/Theatre and Education Association, the essays in this book address the central question of the Congress: What can be the role of drama/theatre and education in a rapidly changing world entering a new…

Evidence, Engagement, and Technology: Themes of and the State of Primary Care Practice-based Network Research.

PubMed

Nease, Donald E

2016-01-01

Practice-based research supported by practice-based research network (PBRN) infrastructure has historically provided an important method for challenging guidelines and evidence arising from secondary and tertiary care settings. This sample of current practice-based research in this issue of the JABFM provides an opportunity to ask whether practice-based research continues to address questions relevant to primary care practices and clinicians and whether a PBRN infrastructure is instrumental to maintaining the relevance and feasibility of practice-based research. Based on this issue's articles, the current state of practice-based research seems to be good, at face value addressing relevant issues for primary care practices. Less clear is the degree to which PBRN infrastructures and relationships informed the questions asked and facilitated the implementation of the studies presented. Practice-based research-related articles that routinely report about how study questions arose-from practices and their clinicians, staff and communities, or elsewhere-could help directly answer questions of relevance. In addition, reporting how practices are recruited to practice-based research studies could inform the degree to which ongoing relationships central to PBRNs facilitate the recruitment and conduct of practice-based research. © Copyright 2016 by the American Board of Family Medicine.

Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: a systematic literature review.

PubMed

Droste, Sigrid; Herrmann-Frank, Annegret; Scheibler, Fueloep; Krones, Tanja

2011-04-15

An effectiveness assessment on ASCT in locally advanced and metastatic breast cancer identified serious ethical issues associated with this intervention. Our objective was to systematically review these aspects by means of a literature analysis. We chose the reflexive Socratic approach as the review method using Hofmann's question list, conducted a comprehensive literature search in biomedical, psychological and ethics bibliographic databases and screened the resulting hits in a 2-step selection process. Relevant arguments were assembled from the included articles, and were assessed and assigned to the question list. Hofmann's questions were addressed by synthesizing these arguments. Of the identified 879 documents 102 included arguments related to one or more questions from Hofmann's question list. The most important ethical issues were the implementation of ASCT in clinical practice on the basis of phase-II trials in the 1990s and the publication of falsified data in the first randomized controlled trials (Bezwoda fraud), which caused significant negative effects on recruiting patients for further clinical trials and the doctor-patient relationship. Recent meta-analyses report a marginal effect in prolonging disease-free survival, accompanied by severe harms, including death. ASCT in breast cancer remains a stigmatized technology. Reported health-related-quality-of-life data are often at high risk of bias in favor of the survivors. Furthermore little attention has been paid to those patients who were dying. The questions were addressed in different degrees of completeness. All arguments were assignable to the questions. The central ethical dimensions of ASCT could be discussed by reviewing the published literature.

Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: A systematic literature review

PubMed Central

2011-01-01

Background An effectiveness assessment on ASCT in locally advanced and metastatic breast cancer identified serious ethical issues associated with this intervention. Our objective was to systematically review these aspects by means of a literature analysis. Methods We chose the reflexive Socratic approach as the review method using Hofmann's question list, conducted a comprehensive literature search in biomedical, psychological and ethics bibliographic databases and screened the resulting hits in a 2-step selection process. Relevant arguments were assembled from the included articles, and were assessed and assigned to the question list. Hofmann's questions were addressed by synthesizing these arguments. Results Of the identified 879 documents 102 included arguments related to one or more questions from Hofmann's question list. The most important ethical issues were the implementation of ASCT in clinical practice on the basis of phase-II trials in the 1990s and the publication of falsified data in the first randomized controlled trials (Bezwoda fraud), which caused significant negative effects on recruiting patients for further clinical trials and the doctor-patient relationship. Recent meta-analyses report a marginal effect in prolonging disease-free survival, accompanied by severe harms, including death. ASCT in breast cancer remains a stigmatized technology. Reported health-related-quality-of-life data are often at high risk of bias in favor of the survivors. Furthermore little attention has been paid to those patients who were dying. Conclusions The questions were addressed in different degrees of completeness. All arguments were assignable to the questions. The central ethical dimensions of ASCT could be discussed by reviewing the published literature. PMID:21496244

Max '91: Flare research at the next solar maximum

NASA Technical Reports Server (NTRS)

Dennis, Brian; Canfield, Richard; Bruner, Marilyn; Emslie, Gordon; Hildner, Ernest; Hudson, Hugh; Hurford, Gordon; Lin, Robert; Novick, Robert; Tarbell, Ted

1988-01-01

To address the central scientific questions surrounding solar flares, coordinated observations of electromagnetic radiation and energetic particles must be made from spacecraft, balloons, rockets, and ground-based observatories. A program to enhance capabilities in these areas in preparation for the next solar maximum in 1991 is recommended. The major scientific issues are described, and required observations and coordination of observations and analyses are detailed. A program plan and conceptual budgets are provided.

Ecoinformatics: supporting ecology as a data-intensive science.

PubMed

Michener, William K; Jones, Matthew B

2012-02-01

Ecology is evolving rapidly and increasingly changing into a more open, accountable, interdisciplinary, collaborative and data-intensive science. Discovering, integrating and analyzing massive amounts of heterogeneous data are central to ecology as researchers address complex questions at scales from the gene to the biosphere. Ecoinformatics offers tools and approaches for managing ecological data and transforming the data into information and knowledge. Here, we review the state-of-the-art and recent advances in ecoinformatics that can benefit ecologists and environmental scientists as they tackle increasingly challenging questions that require voluminous amounts of data across disciplines and scales of space and time. We also highlight the challenges and opportunities that remain. Copyright © 2011 Elsevier Ltd. All rights reserved.

Central localization of plasticity involved in appetitive conditioning in Lymnaea

PubMed Central

Straub, Volko A.; Styles, Benjamin J.; Ireland, Julie S.; O'Shea, Michael; Benjamin, Paul R.

2004-01-01

Learning to associate a conditioned (CS) and unconditioned stimulus (US) results in changes in the processing of CS information. Here, we address directly the question whether chemical appetitive conditioning of Lymnaea feeding behavior involves changes in the peripheral and/or central processing of the CS by using extracellular recording techniques to monitor neuronal activity at two stages of the sensory processing pathway. Our data show that appetitive conditioning does not affect significantly the overall CS response of afferent nerves connecting chemosensory structures in the lips and tentacles to the central nervous system (CNS). In contrast, neuronal output from the cerebral ganglia, which represent the first central processing stage for chemosensory information, is enhanced significantly in response to the CS after appetitive conditioning. This demonstrates that chemical appetitive conditioning in Lymnaea affects the central, but not the peripheral processing of chemosensory information. It also identifies the cerebral ganglia of Lymnaea as an important site for neuronal plasticity and forms the basis for detailed cellular studies of neuronal plasticity. PMID:15537733

A category adjustment approach to memory for spatial location in natural scenes.

PubMed

Holden, Mark P; Curby, Kim M; Newcombe, Nora S; Shipley, Thomas F

2010-05-01

Memories for spatial locations often show systematic errors toward the central value of the surrounding region. This bias has been explained using a Bayesian model in which fine-grained and categorical information are combined (Huttenlocher, Hedges, & Duncan, 1991). However, experiments testing this model have largely used locations contained in simple geometric shapes. Use of this paradigm raises 2 issues. First, do results generalize to the complex natural world? Second, what types of information might be used to segment complex spaces into constituent categories? Experiment 1 addressed the 1st question by showing a bias toward prototypical values in memory for spatial locations in complex natural scenes. Experiment 2 addressed the 2nd question by manipulating the availability of basic visual cues (using color negatives) or of semantic information about the scene (using inverted images). Error patterns suggest that both perceptual and conceptual information are involved in segmentation. The possible neurological foundations of location memory of this kind are discussed. PsycINFO Database Record (c) 2010 APA, all rights reserved.

The influence of spatiotemporal structure of noisy stimuli in decision making.

PubMed

Insabato, Andrea; Dempere-Marco, Laura; Pannunzi, Mario; Deco, Gustavo; Romo, Ranulfo

2014-04-01

Decision making is a process of utmost importance in our daily lives, the study of which has been receiving notable attention for decades. Nevertheless, the neural mechanisms underlying decision making are still not fully understood. Computational modeling has revealed itself as a valuable asset to address some of the fundamental questions. Biophysically plausible models, in particular, are useful in bridging the different levels of description that experimental studies provide, from the neural spiking activity recorded at the cellular level to the performance reported at the behavioral level. In this article, we have reviewed some of the recent progress made in the understanding of the neural mechanisms that underlie decision making. We have performed a critical evaluation of the available results and address, from a computational perspective, aspects of both experimentation and modeling that so far have eluded comprehension. To guide the discussion, we have selected a central theme which revolves around the following question: how does the spatiotemporal structure of sensory stimuli affect the perceptual decision-making process? This question is a timely one as several issues that still remain unresolved stem from this central theme. These include: (i) the role of spatiotemporal input fluctuations in perceptual decision making, (ii) how to extend the current results and models derived from two-alternative choice studies to scenarios with multiple competing evidences, and (iii) to establish whether different types of spatiotemporal input fluctuations affect decision-making outcomes in distinctive ways. And although we have restricted our discussion mostly to visual decisions, our main conclusions are arguably generalizable; hence, their possible extension to other sensory modalities is one of the points in our discussion.

The Influence of Spatiotemporal Structure of Noisy Stimuli in Decision Making

PubMed Central

Deco, Gustavo; Romo, Ranulfo

2014-01-01

Decision making is a process of utmost importance in our daily lives, the study of which has been receiving notable attention for decades. Nevertheless, the neural mechanisms underlying decision making are still not fully understood. Computational modeling has revealed itself as a valuable asset to address some of the fundamental questions. Biophysically plausible models, in particular, are useful in bridging the different levels of description that experimental studies provide, from the neural spiking activity recorded at the cellular level to the performance reported at the behavioral level. In this article, we have reviewed some of the recent progress made in the understanding of the neural mechanisms that underlie decision making. We have performed a critical evaluation of the available results and address, from a computational perspective, aspects of both experimentation and modeling that so far have eluded comprehension. To guide the discussion, we have selected a central theme which revolves around the following question: how does the spatiotemporal structure of sensory stimuli affect the perceptual decision-making process? This question is a timely one as several issues that still remain unresolved stem from this central theme. These include: (i) the role of spatiotemporal input fluctuations in perceptual decision making, (ii) how to extend the current results and models derived from two-alternative choice studies to scenarios with multiple competing evidences, and (iii) to establish whether different types of spatiotemporal input fluctuations affect decision-making outcomes in distinctive ways. And although we have restricted our discussion mostly to visual decisions, our main conclusions are arguably generalizable; hence, their possible extension to other sensory modalities is one of the points in our discussion. PMID:24743140

The Long-Term Agro-Ecosystem Research (LTAR) Network: A New In-Situ Data Network For Agriculture

NASA Astrophysics Data System (ADS)

Walbridge, M. R.

2014-12-01

Agriculture in the 21st Century faces significant challenges due to increases in the demand for agricultural products from a global population expected to reach 9.5 billion by 2050, changes in land use that are reducing the area of arable land worldwide, and the uncertainties associated with increasing climate variability and change. There is broad agreement that meeting these challenges will require significant changes in agro-ecosystem management at the landscape scale. In 2012, the USDA/ARS announced the reorganization of 10 existing benchmark watersheds, experimental ranges, and research farms into a Long-Term Agro-ecosystem Research (LTAR) network. Earlier this year, the LTAR network expanded to 18 sites, including 3 led by land grant universities and/or private foundations. The central question addressed by the LTAR network is, "How do we sustain or enhance productivity, profitability, and ecosystem services in agro-ecosystems and agricultural landscapes"? All 18 LTAR sites possess rich historical databases that extend up to 100 years into the past. However as LTAR moves forward, the focus is on collecting a core set of common measurements over the next 30-50 years that can be used to draw inferences regarding the nature of agricultural sustainability and how it varies across regional and continental-scale gradients. As such, LTAR is part long-term research network and part observatory network. Rather than focusing on a single site, each LTAR has developed regional partnerships that allow it to address agro-ecosystem function in the large basins and eco-climatic zones that underpin regional food production systems. Partners include other long-term in-situ data networks (e.g., Ameriflux, CZO, GRACEnet, LTER, NEON). 'Next steps' include designing and implementing a cross-site experiment addressing LTAR's central question.

Validation of the TOLNet lidars during SCOOP (Southern California Ozone Observation Project)

NASA Astrophysics Data System (ADS)

Leblanc, Thierry; Granados-Munoz, Maria-Jose; Strawbridge, Kevin; Senff, Chris; Langford, Andy; Berkoff, Tim; Gronoff, Guillaume; DeYoung, Russel; Carion, Bill; Chen, G.; Sullivan, John; McGee, Tom; Jonhson, M.; Kuang, S.; Newchurch, Mike

2018-04-01

Five TOLNet lidars participated to a validation campaign at the JPL-Table Mountain Facility, CA in August 2016. All lidars agreed within ±10% of each other and within ±7% of the ozonesondes. Centralized data processing was used to compare the uncertainty budgets. The results highlight the TOLNet potential to address science questions ranging from boundary layer processes to long range transport. TOLNet can now be seen as a robust network for use in field campaigns and long term monitoring.

A Review of Concepts from Policy Studies Relevant to the Analysis of EFA in Developing Countries. Create Pathways to Access. Research Monograph No. 11

ERIC Educational Resources Information Center

Lall, Marie

2007-01-01

This paper aims to give an introduction to the central concepts and the literature of Policy Studies in education. The first part of the paper addresses the questions of what policy is. How is it made and why is it relevant? It looks in particular at the role of the state and the Policy cycle framework which is an analytical tool that helps to…

Federal Organization for Technological Innovation. Hearings before the Subcommittee on Science, Research and Technology of the Committee on Science and Technology. House of Representatives, Ninety-Eighth Congress, Second Session (June 7, 12, 13, 14, 1984). No. 127.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Science and Technology.

These hearings focused on a number of bills that, in various degrees, call for new organizational arrangements in the federal government, for a stronger role in technological innovation. The central question addressed was whether the advancement of American technology needs the active participation of the federal government, be it in the currently…

Solar Orbiter: Exploring the Sun-Heliosphere Connection

NASA Technical Reports Server (NTRS)

Mueller, D.; Marsden, R. G.; St.Cyr, O. C.; Gilbert, H. R.

2013-01-01

The heliosphere represents a uniquely accessible domain of space, where fundamental physical processes common to solar, astrophysical and laboratory plasmas can be studied under conditions impossible to reproduce on Earth and unfeasible to observe from astronomical distances. Solar Orbiter, the first mission of ESA's Cosmic Vision 2015 - 2025 programme, will address the central question of heliophysics: How does the Sun create and control the heliosphere? In this paper, we present the scientific goals of the mission and provide an overview of the mission implementation.

Solar Orbiter Exploring the Sun-Heliosphere Connection

NASA Technical Reports Server (NTRS)

Mueller, Daniel; Marsden, Richard George; Cyr, O. C. St.; Gilbert, Holly Robin

2012-01-01

The heliosphere represents a uniquely accessible domain of space, where fundamental physical processes common to solar, astrophysical and laboratory plasmas can be studied under conditions impossible to reproduce on Earth and unfeasible to observe from astronomical distances. Solar Orbiter, the first mission of ESA's Cosmic Vision 2015 - 2025 programme, will address the central question of heliophysics: How does the Sun create and control the heliosphere? In this paper, we present the scientific goals of the mission and provide an overview of the mission implementation.

Acoustic telemetry and fisheries management

USGS Publications Warehouse

Crossin, Glenn T.; Heupel, Michelle R.; Holbrook, Christopher; Hussey, Nigel E.; Lowerre-Barbieri, Susan K.; Nguyen, Vivian M.; Raby, Graham D.; Cooke, Steven J.

2017-01-01

This paper reviews the use of acoustic telemetry as a tool for addressing issues in fisheries management, and serves as the lead to the special Feature Issue of Ecological Applications titled “Acoustic Telemetry and Fisheries Management”. Specifically, we provide an overview of the ways in which acoustic telemetry can be used to inform issues central to the ecology, conservation, and management of exploited and/or imperiled fish species. Despite great strides in this area in recent years, there are comparatively few examples where data have been applied directly to influence fisheries management and policy. We review the literature on this issue, identify the strengths and weaknesses of work done to date, and highlight knowledge gaps and difficulties in applying empirical fish telemetry studies to fisheries policy and practice. We then highlight the key areas of management and policy addressed, as well as the challenges that needed to be overcome to do this. We conclude with a set of recommendations about how researchers can, in consultation with stock assessment scientists and managers, formulate testable scientific questions to address and design future studies to generate data that can be used in a meaningful way by fisheries management and conservation practitioners. We also urge the involvement of relevant stakeholders (managers, fishers, conservation societies, etc.) early on in the process (i.e. in the co-creation of research projects), so that all priority questions and issues can be addressed effectively.

Central load reduces peripheral processing: Evidence from incidental memory of background speech.

PubMed

Halin, Niklas; Marsh, John E; Sörqvist, Patrik

2015-12-01

Is there a trade-off between central (working memory) load and peripheral (perceptual) processing? To address this question, participants were requested to undertake an n-back task in one of two levels of central/cognitive load (i.e., 1-back or 2-back) in the presence of a to-be-ignored story presented via headphones. Participants were told to ignore the background story, but they were given a surprise memory test of what had been said in the background story, immediately after the n-back task was completed. Memory was poorer in the high central load (2-back) condition in comparison with the low central load (1-back) condition. Hence, when people compensate for higher central load, by increasing attentional engagement, peripheral processing is constrained. Moreover, participants with high working memory capacity (WMC) - with a superior ability for attentional engagement - remembered less of the background story, but only in the low central load condition. Taken together, peripheral processing - as indexed by incidental memory of background speech - is constrained when task engagement is high. © 2015 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Global information sampling in the honey bee

NASA Astrophysics Data System (ADS)

Johnson, Brian R.

2008-06-01

Central to the question of task allocation in social insects is how workers acquire information. Patrolling is a curious behavior in which bees meander over the face of the comb inspecting cells. Several authors have suggested it allows bees to collect global information, but this has never been formally evaluated. This study explores this hypothesis by answering three questions. First, do bees gather information in a consistent manner as they patrol? Second, do they move far enough to get a sense of task demand in distant areas of the nest? And third, is patrolling a commonly performed task? Focal animal observations were used to address the first two predictions, while a scan sampling study was used to address the third. The results were affirmative for each question. While patrolling, workers collected information by performing periodic clusters of cell inspections. Patrolling bees not only traveled far enough to frequently change work zone; they often visited every part of the nest. Finally, the majority of the bees in the middle-age caste were shown to move throughout the nest over the course of a few hours in a manner suggestive of patrolling. Global information collection is contrary to much current theory, which assumes that workers respond to local information only. This study thus highlights the nonmutually exclusive nature of various information collection regimes in social insects.

The future of graduate medical education in Germany - position paper of the Committee on Graduate Medical Education of the Society for Medical Education (GMA).

PubMed

David, Dagmar M; Euteneier, Alexander; Fischer, Martin R; Hahn, Eckhart G; Johannink, Jonas; Kulike, Katharina; Lauch, Robert; Lindhorst, Elmar; Noll-Hussong, Michael; Pinilla, Severin; Weih, Markus; Wennekes, Vanessa

2013-01-01

The German graduate medical education system is going through an important phase of changes. Besides the ongoing reform of the national guidelines for graduate medical education (Musterweiterbildungsordnung), other factors like societal and demographic changes, health and research policy reforms also play a central role for the future and competitiveness of graduate medical education. With this position paper, the committee on graduate medical education of the Society for Medical Education (GMA) would like to point out some central questions for this process and support the current discourse. As an interprofessional and interdisciplinary scientific society, the GMA has the resources to contribute in a meaningful way to an evidence-based and future-oriented graduate medical education strategy. In this position paper, we use four key questions with regards to educational goals, quality assurance, teaching competence and policy requirements to address the core issues for the future of graduate medical education in Germany. The GMA sees its task in contributing to the necessary reform processes as the only German speaking scientific society in the field of medical education.

Solar Orbiter Status Update

NASA Astrophysics Data System (ADS)

Zouganelis, Y.; Mueller, D.; St Cyr, O. C.; Gilbert, H. R.

2016-12-01

Solar Orbiter, the first mission of ESA's Cosmic Vision 2015-2025 programme, promises to deliver groundbreaking science with previously unavailable observational capabilities provided by a suite of in-situ and remote-sensing instruments in a unique orbit. The mission will address the central question of heliophysics: How does the Sun create and control the heliosphere? The heliosphere represents a uniquely accessible domain of space, where fundamental physical processes common to solar, astrophysical and laboratory plasmas can be studied under conditions impossible to reproduce on Earth and unfeasible to observe from astronomical distances. In this talk, we highlight the scientific goals of Solar Orbiter, address the synergy between this joint ESA/NASA mission and other new space and ground-based observatories, and present the mission's development status.

Clinical Uncertainties, Health Service Challenges, and Ethical Complexities of HIV “Test-and-Treat”: A Systematic Review

PubMed Central

Shah, Kavita R.; Sarma, Karthik V.; Mahajan, Anish P.

2013-01-01

Despite the HIV “test-and-treat” strategy’s promise, questions about its clinical rationale, operational feasibility, and ethical appropriateness have led to vigorous debate in the global HIV community. We performed a systematic review of the literature published between January 2009 and May 2012 using PubMed, SCOPUS, Global Health, Web of Science, BIOSIS, Cochrane CENTRAL, EBSCO Africa-Wide Information, and EBSCO CINAHL Plus databases to summarize clinical uncertainties, health service challenges, and ethical complexities that may affect the test-and-treat strategy’s success. A thoughtful approach to research and implementation to address clinical and health service questions and meaningful community engagement regarding ethical complexities may bring us closer to safe, feasible, and effective test-and-treat implementation. PMID:23597344

The Evolution of Dust in the Multiphase Interstellar Medium

NASA Technical Reports Server (NTRS)

Oliversen, Ronald J. (Technical Monitor); Slavin, Jonathan

2003-01-01

Interstellar dust has a profound effect on the structure and evolution of the interstellar medium (ISM) and on the processes by which stars form from it. Dust obscures regions of star formation from view, and the uncertain quantities of elements in dust makes it difficult to measure accurately the abundances of the elements in low density regions. Despite the central importance of dust in astrophysics, we cannot answer some of the most basic questions about it: Why is it that most of the refractory elements are in dust grains? What determines the sizes of interstellar grains? It has been the goal of our proposed theoretical investigations to address these questions by studying the destruction of interstellar grains, and to develop observational diagnostics that can test the models we develop.

Is Mandarin Chinese a Truth-Based Language? Rejecting Responses to Negative Assertions and Questions

PubMed Central

Li, Feifei; González-Fuente, Santiago; Prieto, Pilar; Espinal, M.Teresa

2016-01-01

This paper addresses the central question of whether Mandarin Chinese (MC) is a canonical truth-based language, a language that is expected to express the speaker's disagreement to a negative proposition by means of a negative particle followed by a positive sentence. Eight native speakers of MC participated in an oral Discourse Completion Task that elicited rejecting responses to negative assertions/questions and broad focus statements (control condition). Results show that MC speakers convey reject by relying on a combination of lexico-syntactic strategies (e.g., negative particles such as bù, méi(yǒu), and positive sentences) together with prosodic (e.g., mean pitch) and gestural strategies (mainly, the use of head nods). Importantly, the use of a negative particle, which was the expected outcome in truth-based languages, only appeared in 52% of the rejecting answers. This system puts into question the macroparametric division between truth-based and polarity-based languages and calls for a more general view of the instantiation of a reject speech act that integrates lexical and syntactic strategies with prosodic and gestural strategies. PMID:28066292

Critical Review of Technical Questions Facing Low Impact Development and Green Infrastructure: A Perspective from the Great Plains.

PubMed

Vogel, Jason R; Moore, Trisha L; Coffman, Reid R; Rodie, Steven N; Hutchinson, Stacy L; McDonough, Kelsey R; McLemore, Alex J; McMaine, John T

2015-09-01

Since its inception, Low Impact Development (LID) has become part of urban stormwater management across the United States, marking progress in the gradual transition from centralized to distributed runoff management infrastructure. The ultimate goal of LID is full, cost-effective implementation to maximize watershed-scale ecosystem services and enhance resilience. To reach that goal in the Great Plains, the multi-disciplinary author team presents this critical review based on thirteen technical questions within the context of regional climate and socioeconomics across increasing complexities in scale and function. Although some progress has been made, much remains to be done including continued basic and applied research, development of local LID design specifications, local demonstrations, and identifying funding mechanisms for these solutions. Within the Great Plains and beyond, by addressing these technical questions within a local context, the goal of widespread acceptance of LID can be achieved, resulting in more effective and resilient stormwater management.

Top 10 research questions related to growth and maturation of relevance to physical activity, performance, and fitness.

PubMed

Malina, Robert M

2014-06-01

Growth, maturation, and development dominate the daily lives of children and adolescents for approximately the first 2 decades of life. Growth and maturation are biological processes, while development is largely a behavioral process. The 3 processes occur simultaneously and interact. They can be influenced by physical activity and also can influence activity, performance, and fitness. Allowing for these potential interactions, 10 questions on growth and maturation that have relevance to physical activity, performance, and fitness are presented. The questions are not mutually exclusive and address several broadly defined topical areas: exercise and growth, body weight status (body mass index, adiposity rebound, "unhealthy weight gain"), movement proficiency (hypothesized barrier, role in obesity), individual differences, tracking, maturity-associated variation in performance, and corresponding variation in physical activity. Central to the discussion of each is the need for a biocultural approach recognizing the interactions of biology and behavior as potential influences on the variables of interest.

Carbon Metabolic Pathways in Phototrophic Bacteria and Their Broader Evolutionary Implications

PubMed Central

Tang, Kuo-Hsiang; Tang, Yinjie J.; Blankenship, Robert Eugene

2011-01-01

Photosynthesis is the biological process that converts solar energy to biomass, bio-products, and biofuel. It is the only major natural solar energy storage mechanism on Earth. To satisfy the increased demand for sustainable energy sources and identify the mechanism of photosynthetic carbon assimilation, which is one of the bottlenecks in photosynthesis, it is essential to understand the process of solar energy storage and associated carbon metabolism in photosynthetic organisms. Researchers have employed physiological studies, microbiological chemistry, enzyme assays, genome sequencing, transcriptomics, and 13C-based metabolomics/fluxomics to investigate central carbon metabolism and enzymes that operate in phototrophs. In this report, we review diverse CO2 assimilation pathways, acetate assimilation, carbohydrate catabolism, the tricarboxylic acid cycle and some key, and/or unconventional enzymes in central carbon metabolism of phototrophic microorganisms. We also discuss the reducing equivalent flow during photoautotrophic and photoheterotrophic growth, evolutionary links in the central carbon metabolic network, and correlations between photosynthetic and non-photosynthetic organisms. Considering the metabolic versatility in these fascinating and diverse photosynthetic bacteria, many essential questions in their central carbon metabolism still remain to be addressed. PMID:21866228

Control of Cell Survival in Adult Mammalian Neurogenesis.

PubMed

Kuhn, H Georg

2015-10-28

The fact that continuous proliferation of stem cells and progenitors, as well as the production of new neurons, occurs in the adult mammalian central nervous system (CNS) raises several basic questions concerning the number of neurons required in a particular system. Can we observe continued growth of brain regions that sustain neurogenesis? Or does an elimination mechanism exist to maintain a constant number of cells? If so, are old neurons replaced, or are the new neurons competing for limited network access among each other? What signals support their survival and integration and what factors are responsible for their elimination? This review will address these and other questions regarding regulatory mechanisms that control cell-death and cell-survival mechanisms during neurogenesis in the intact adult mammalian brain. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

Illusory ownership of an invisible body reduces autonomic and subjective social anxiety responses.

PubMed

Guterstam, Arvid; Abdulkarim, Zakaryah; Ehrsson, H Henrik

2015-04-23

What is it like to be invisible? This question has long fascinated man and has been the central theme of many classic literary works. Recent advances in materials science suggest that invisibility cloaking of the human body may be possible in the not-so-distant future. However, it remains unknown how invisibility affects body perception and embodied cognition. To address these questions, we developed a perceptual illusion of having an entire invisible body. Through a series of experiments, we characterized the multisensory rules that govern the elicitation of the illusion and show that the experience of having an invisible body reduces the social anxiety response to standing in front of an audience. This study provides an experimental model of what it is like to be invisible and shows that this experience affects bodily self-perception and social cognition.

How Does The Universe Work? The Physics Of The Cosmos Program (PCOS)

NASA Astrophysics Data System (ADS)

Sambruna, Rita M.

2011-09-01

The Physics of the Cosmos (PCOS) program incorporates cosmology, high-energy astrophysics, and fundamental physics projects aimed at addressing central questions about the nature of complex astrophysical phenomena such as black holes, neutron stars, dark energy, and gravitational waves. Its overarching theme is, How does the Universe work? PCOS includes a suite of operating (Chandra, Fermi, Planck, XMM-Newton, INTEGRAL) and future missions across the electromagnetic spectrum and beyond, which are in concept development and/or formulation. The PCOS program directly supports development of intermediate TRL (4-6) technology relevant to future missions through the Strategic Astrophysics Technology (SAT) program, as well as data analysis, theory, and experimental astrophysics via other R&A avenues (e.g., ADAP, ATP). The Einstein Fellowship is a vital and vibrant PCOS component funded by the program. PCOS receives community input via its Program Analysis Group, the PhysPAG (www.pcos.gsfc.nasa.gov/physpag.php), whose membership and meetings are open to the community at large. In this poster, we describe the detailed science questions addressed within PCOS, with special emphasis on future opportunities. Details about the PhysPAG operations and functions will be provided, as well as an update on future meetings.

Clouds and Water Vapor in the Climate System: Remotely Piloted Aircraft and Satellites

NASA Technical Reports Server (NTRS)

Anderson, James G.

1999-01-01

The objective of this work was to attack unanswered questions that lie at the intersection of radiation, dynamics, chemistry and climate. Considerable emphasis was placed on scientific collaboration and the innovative development of instruments required to address these scientific issues. The specific questions addressed include: Water vapor distribution in the Tropical Troposphere: An understanding of the mechanisms that dictate the distribution of water vapor in the middle-upper troposphere; Atmospheric Radiation: In the spectral region between 200 and 600/cm that encompasses the water vapor rotational and continuum structure, where most of the radiative cooling of the upper troposphere occurs, there is a critical need to test radiative transfer calculations using accurate, spectrally resolved radiance observations of the cold atmosphere obtained simultaneously with in situ species concentrations; Thin Cirrus: Cirrus clouds play a central role in the energy and water budgets of the tropical tropopause region; Stratosphere-Troposphere Exchange: Assessment of our ability to predict the behavior of the atmosphere to changes in the boundary conditions defined by thermal, chemical or biological variables; Correlative Science with Satellite Observations: Linking this research to the developing series of EOS observations is critical for scientific progress.

Cell biology in China: Focusing on the lysosome.

PubMed

Yang, Chonglin; Wang, Xiaochen

2017-06-01

The view that lysosomes are merely the recycling bins of the cell has changed greatly during recent years. Lysosomes are now known to play a central role in signal transduction, cellular adaptation, plasma membrane repair, immune responses and many other fundamental cellular processes. In conjunction with the seminal discoveries made by international colleagues, many important questions regarding lysosomes are being addressed by Chinese scientists. In this review, we briefly summarize recent exciting findings in China on lysosomal signaling, biogenesis, integrity and physiological functions. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management.

PubMed

Sinnecker, Tim; Kuchling, Joseph; Dusek, Petr; Dörr, Jan; Niendorf, Thoralf; Paul, Friedemann; Wuerfel, Jens

2015-01-01

Conventional magnetic resonance imaging (MRI) at 1.5 Tesla (T) is limited by modest spatial resolution and signal-to-noise ratio (SNR), impeding the identification and classification of inflammatory central nervous system changes in current clinical practice. Gaining from enhanced susceptibility effects and improved SNR, ultrahigh field MRI at 7 T depicts inflammatory brain lesions in great detail. This review summarises recent reports on 7 T MRI in neuroinflammatory diseases and addresses the question as to whether ultrahigh field MRI may eventually improve clinical decision-making and personalised disease management.

Application of future remote sensing systems to irrigation

NASA Technical Reports Server (NTRS)

Miller, L. D.

1982-01-01

Area estimates of irrigated crops and knowledge of crop type are required for modeling water consumption to assist farmers, rangers, and agricultural consultants in scheduling irrigation for distributed management of crop yields. Information on canopy physiology and soil moisture status on a spatial basis is potentially available from remote sensors, so the questions to be addressed relate to: (1) timing (data frequency, instantaneous and integrated measurement); and scheduling (widely distributed spatial demands); (2) spatial resolution; (3) radiometric and geometric accuracy and geoencoding; and (4) information/data distribution. This latter should be overnight, with no central storage, onsite capture, and low cost.

Converging roles for sphingolipids and cell stress in the progression of neurological dysfunction in AIDS

PubMed Central

Haughey, Norman J.; Steiner, Joesph; Nath, Avindra; McArthur, Justin; Sacktor, Ned; Pardo, Carlos; Bandaru, Veera Venkata Ratnam

2009-01-01

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling. PMID:18508574

A critical review of recent US market level health care strategy literature.

PubMed

Wells, R; Banaszak-Holl, J

2000-09-01

In this review, we argue that it would be profitable if the neoclassical economic theories that have dominated recent US market level health care strategy research could be complemented by greater use of sociological frameworks. Sociological theory can address three central questions that neoclassical economic theories have tended to slight: (1) how decision-makers' preferences are determined; (2) who the decision-makers are; and (3) how decision-makers' plans are translated into organizational action. We suggest five sociological frameworks that would enable researchers to address these issues better relative to market level strategy in health care. The frameworks are (1) institutional theory, (2) organizational ecology, (3) social movements, (4) social networks, and (5) internal organizational change. A recent global trend toward privatization of health care provision makes US market level strategy research increasingly applicable to non-US readers.

Fundamental contradictions in cultural competence.

PubMed

Johnson, Yvonne M; Munch, Shari

2009-07-01

Cultural competence (CC) is considered highly relevant to social work practice with clients belonging to ethnic and racial minority groups, as the burgeoning literature and creation of practice standards on CC attest. However, examination of the conceptual underpinnings of CC reveals several major anomalies. The authors argue that several aspects of CC contradict central social work concepts or are at odds with current, standard social work practice. These contradictions extend to the epistemological foundations of CC and the rights and dignity of the individual. To further stress the conceptual tensions at the heart of CC, the authors incorporate recent philosophical work addressing collective identities and group rights. The question of whether culturally competent practice is achievable is also addressed. The authors urge academicians and practitioners to thoroughly examine the theoretical and ethical bases of CC because of their highly important ramifications for social work practice.

Governing decentralization in health care under tough budget constraint: what can we learn from the Italian experience?

PubMed

Tediosi, Fabrizio; Gabriele, Stefania; Longo, Francesco

2009-05-01

In many European countries, since the World War II, there has been a trend towards decentralization of health policy to lower levels of governments, while more recently there have been re-centralization processes. Whether re-centralization will be the new paradigm of European health policy or not is difficult to say. In the Italian National Health Service (SSN) decentralization raised two related questions that might be interesting for the international debate on decentralization in health care: (a) what sort of regulatory framework and institutional balances are required to govern decentralization in health care in a heterogeneous country under tough budget constraints? (b) how can it be ensured that the most advanced parts of the country remain committed to solidarity, supporting the weakest ones? To address these questions this article describes the recent trends in SSN funding and expenditure, it reviews the strategy adopted by the Italian government for governing the decentralization process and discusses the findings to draw policy conclusions. The main lessons emerging from this experience are that: (1) when the differences in administrative and policy skills, in socio-economic standards and social capital are wide, decentralization may lead to undesirable divergent evolution paths; (2) even in decentralized systems, the role of the Central government can be very important to contain health expenditure; (3) a strong governance of the Central government may help and not hinder the enforcement of decentralization; and (4) supporting the weakest Regions and maintaining inter-regional solidarity is hard but possible. In Italy, despite an increasing role of the Central government in steering the SSN, the pattern of regional decentralization of health sector decision making does not seem at risk. Nevertheless, the Italian case confirms the complexity of decentralization and re-centralization processes that sometimes can be paradoxically reinforcing each other.

Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.

PubMed

Kündig, Pascale; Giesen, Charlotte; Jackson, Hartland; Bodenmiller, Bernd; Papassotirolopus, Bärbel; Freiberger, Sandra Nicole; Aquino, Catharine; Opitz, Lennart; Varga, Zsuzsanna

2018-05-08

Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. A concept describing the origin of intra-tumoral heterogeneity is the cancer stem-cell hypothesis, proposing the existence of cancer stem cells that can self-renew limitlessly and therefore lead to tumor progression. Clonal evolution in accumulated single cell genomic alterations is a further possible explanation in carcinogenesis. In this study, we addressed the question whether intra-tumoral heterogeneity can be reliably detected in tissue-micro-arrays in breast cancer by comparing expression levels of conventional predictive/prognostic tumor markers, tumor progression markers and stem cell markers between central and peripheral tumor areas. We analyzed immunohistochemical expression and/or gene amplification status of conventional prognostic tumor markers (ER, PR, HER2, CK5/6), tumor progression markers (PTEN, PIK3CA, p53, Ki-67) and stem cell markers (mTOR, SOX2, SOX9, SOX10, SLUG, CD44, CD24, TWIST) in 372 tissue-micro-array samples from 72 breast cancer patients. Expression levels were compared between central and peripheral tumor tissue areas and were correlated to histopathological grading. 15 selected cases additionally underwent RNA sequencing for transcriptome analysis. No significant difference in any of the analyzed between central and peripheral tumor areas was seen with any of the analyzed methods/or results that showed difference. Except mTOR, PIK3CA and SOX9 (nuclear) protein expression, all markers correlated significantly (p < 0.05) with histopathological grading both in central and peripheral areas. Our results suggest that intra-tumoral heterogeneity of stem-cell and tumor-progression markers cannot be reliably addressed in tissue-micro-array samples in breast cancer. However, most markers correlated strongly with histopathological grading confirming prognostic information as expression profiles were independent on the site of the biopsy was taken.

Clonal evolution of chemotherapy-resistant urothelial carcinoma.

PubMed

Faltas, Bishoy M; Prandi, Davide; Tagawa, Scott T; Molina, Ana M; Nanus, David M; Sternberg, Cora; Rosenberg, Jonathan; Mosquera, Juan Miguel; Robinson, Brian; Elemento, Olivier; Sboner, Andrea; Beltran, Himisha; Demichelis, Francesca; Rubin, Mark A

2016-12-01

Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy. Our analysis provided several insights: (i) chemotherapy-treated urothelial carcinoma is characterized by intra-patient mutational heterogeneity, and the majority of mutations are not shared; (ii) both branching evolution and metastatic spread are very early events in the natural history of urothelial carcinoma; (iii) chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell adhesion molecule (L1CAM) and integrin signaling pathways; and (iv) APOBEC-induced mutagenesis is clonally enriched in chemotherapy-treated urothelial carcinoma and continues to shape the evolution of urothelial carcinoma throughout its lifetime.

Clonal Evolution of Chemotherapy-resistant Urothelial Carcinoma

PubMed Central

Faltas, Bishoy M.; Prandi, Davide; Tagawa, Scott T.; Molina, Ana M.; Nanus, David M.; Sternberg, Cora; Rosenberg, Jonathan; Mosquera, Juan Miguel; Robinson, Brian; Elemento, Olivier; Sboner, Andrea; Beltran, Himisha; Demichelis, Francesca; Rubin, Mark A.

2017-01-01

Chemotherapy-resistant urothelial carcinoma (UC) has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs UC’s evolution and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 UCs including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy. Our analysis provided several insights: (i) chemotherapy-treated UC is characterized by intra-patient mutational heterogeneity and the majority of mutations are not shared, (ii) both branching evolution and metastatic spread are very early events in the natural history of UC; (iii) chemotherapy-treated UC is enriched with clonal mutations involving L1-cell adhesion molecule (L1CAM) and integrin signaling pathways; (iv) APOBEC induced-mutagenesis is clonally-enriched in chemotherapy-treated UC and continues to shape UC’s evolution throughout its lifetime. PMID:27749842

Return of research results from pharmacogenomic versus disease susceptibility studies: what’s drugs got to do with it?

PubMed Central

Dressler, Lynn G

2012-01-01

One of the most controversial ethical issues in genomics research is the return of individual research results to research subjects. As new technologies, including whole-genome sequencing, provide an increased opportunity for researchers to find clinically relevant research results, the questions related to if, when and how individual research results should be returned become more central to the ethical conduct of genomic research. In the absence of federal guidance on this issue, many groups and individuals have developed recommendations and suggestions to address these questions. Most of these recommendations have focused on the return of individual results from disease susceptibility studies. However, in addition to predicting the development of disease, genomic research also includes predicting an individual’s response to drugs, especially the risk of developing adverse events. This article evaluates and compares the return of individual research results from disease susceptibility studies versus pharmacogenomic studies. PMID:22676197

Return of research results from pharmacogenomic versus disease susceptibility studies: what's drugs got to do with it?

PubMed

Dressler, Lynn G

2012-06-01

One of the most controversial ethical issues in genomics research is the return of individual research results to research subjects. As new technologies, including whole-genome sequencing, provide an increased opportunity for researchers to find clinically relevant research results, the questions related to if, when and how individual research results should be returned become more central to the ethical conduct of genomic research. In the absence of federal guidance on this issue, many groups and individuals have developed recommendations and suggestions to address these questions. Most of these recommendations have focused on the return of individual results from disease susceptibility studies. However, in addition to predicting the development of disease, genomic research also includes predicting an individual's response to drugs, especially the risk of developing adverse events. This article evaluates and compares the return of individual research results from disease susceptibility studies versus pharmacogenomic studies.

Scaling, soil moisture and evapotranspiration in runoff models

NASA Technical Reports Server (NTRS)

Wood, Eric F.

1993-01-01

The effects of small-scale heterogeneity in land surface characteristics on the large-scale fluxes of water and energy in the land-atmosphere system has become a central focus of many of the climatology research experiments. The acquisition of high resolution land surface data through remote sensing and intensive land-climatology field experiments (like HAPEX and FIFE) has provided data to investigate the interactions between microscale land-atmosphere interactions and macroscale models. One essential research question is how to account for the small scale heterogeneities and whether 'effective' parameters can be used in the macroscale models. To address this question of scaling, the probability distribution for evaporation is derived which illustrates the conditions for which scaling should work. A correction algorithm that may appropriate for the land parameterization of a GCM is derived using a 2nd order linearization scheme. The performance of the algorithm is evaluated.

Illusory ownership of an invisible body reduces autonomic and subjective social anxiety responses

PubMed Central

Guterstam, Arvid; Abdulkarim, Zakaryah; Ehrsson, H. Henrik

2015-01-01

What is it like to be invisible? This question has long fascinated man and has been the central theme of many classic literary works. Recent advances in materials science suggest that invisibility cloaking of the human body may be possible in the not-so-distant future. However, it remains unknown how invisibility affects body perception and embodied cognition. To address these questions, we developed a perceptual illusion of having an entire invisible body. Through a series of experiments, we characterized the multisensory rules that govern the elicitation of the illusion and show that the experience of having an invisible body reduces the social anxiety response to standing in front of an audience. This study provides an experimental model of what it is like to be invisible and shows that this experience affects bodily self-perception and social cognition. PMID:25906330

Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions.

PubMed

Camilleri, Michael; Oduyebo, Ibironke; Halawi, Houssam

2016-11-01

Several chemical and molecular factors in the intestine are reported to be altered and to have a potentially significant role in irritable bowel syndrome (IBS), particularly in IBS with diarrhea. These include bile acids; short-chain fatty acids; mucosal barrier proteins; mast cell products such as histamine, proteases, and tryptase; enteroendocrine cell products; and mucosal mRNAs, proteins, and microRNAs. This article reviews the current knowledge and unanswered questions in the pathobiology of the chemical and molecular factors in IBS. Evidence continues to point to significant roles in pathogenesis of these chemical and molecular mechanisms, which may therefore constitute potential targets for future research and therapy. However, it is still necessary to address the interaction between these factors in the gut and to appraise how they may influence hypervigilance in the central nervous system in patients with IBS. Copyright © 2016 the American Physiological Society.

The impact of climate change on transportation in the gulf coast

USGS Publications Warehouse

Savonis, M.J.; Burkett, V.R.; Potter, J.R.; Kafalenos, R.; Hyman, R.; Leonard, K.

2009-01-01

Climate affects the design, construction, safety, operations, and maintenance of transportation infrastructure and systems. The prospect of a changing climate raises critical questions regarding how alterations in temperature, precipitation, storm events, and other aspects of the climate could affect the nation's transportation system. This regional assessment of climate change and its potential impacts on transportation systems addresses these questions for the central Gulf Coast between Houston and Mobile. Warming temperatures are likely to increase the costs of transportation construction, maintenance, and operations. More frequent extreme precipitation events will likely disrupt transportation networks with flooding and visibility problems. Relative sea level rise will make much of the existing infrastructure more prone to frequent or permanent inundation. Increased storm intensity may lead to increased service disruption and damage. Consideration of these factors in today's transportation decisions should lead to a more robust, resilient, and cost-effective transportation network in the coming decades. ?? 2009 ASCE.

Perspectives in quantum physics: Epistemological, ontological and pedagogical An investigation into student and expert perspectives on the physical interpretation of quantum mechanics, with implications for modern physics instruction

NASA Astrophysics Data System (ADS)

Baily, Charles Raymond

A common learning goal for modern physics instructors is for students to recognize a difference between the experimental uncertainty of classical physics and the fundamental uncertainty of quantum mechanics. Our studies suggest this notoriously difficult task may be frustrated by the intuitively realist perspectives of introductory students, and a lack of ontological flexibility in their conceptions of light and matter. We have developed a framework for understanding and characterizing student perspectives on the physical interpretation of quantum mechanics, and demonstrate the differential impact on student thinking of the myriad ways instructors approach interpretive themes in their introductory courses. Like expert physicists, students interpret quantum phenomena differently, and these interpretations are significantly influenced by their overall stances on questions central to the so-called measurement problem: Is the wave function physically real, or simply a mathematical tool? Is the collapse of the wave function an ad hoc rule, or a physical transition not described by any equation? Does an electron, being a form of matter, exist as a localized particle at all times? These questions, which are of personal and academic interest to our students, are largely only superficially addressed in our introductory courses, often for fear of opening a Pandora's Box of student questions, none of which have easy answers. We show how a transformed modern physics curriculum (recently implemented at the University of Colorado) may positively impact student perspectives on indeterminacy and wave-particle duality, by making questions of classical and quantum reality a central theme of our course, but also by making the beliefs of our students, and not just those of scientists, an explicit topic of discussion.

Questions for Music Education Research

ERIC Educational Resources Information Center

Jorgensen, Estelle R.

2008-01-01

In addressing the question-set "What questions do music education researchers need to address?", an illustrative list of juxtaposed descriptive and normative questions is sketched as follows: What are and should be the dimensions of music education? What are and should be the institutional agencies of music education? What are and should be the…

Centralization Versus Decentralization: A Location Analysis Approach for Librarians.

ERIC Educational Resources Information Center

Shishko, Robert; Raffel, Jeffrey

One of the questions that seems to perplex many university and special librarians is whether to move in the direction of centralizing or decentralizing the library's collections and facilities. Presented is a theoretical approach, employing location theory, to the library centralization-decentralization question. Location theory allows the analyst…

Switching between simple cognitive tasks: the interaction of top-down and bottom-up factors

NASA Technical Reports Server (NTRS)

Ruthruff, E.; Remington, R. W.; Johnston, J. C.

2001-01-01

How do top-down factors (e.g., task expectancy) and bottom-up factors (e.g., task recency) interact to produce an overall level of task readiness? This question was addressed by factorially manipulating task expectancy and task repetition in a task-switching paradigm. The effects of expectancy and repetition on response time tended to interact underadditively, but only because the traditional binary task-repetition variable lumps together all switch trials, ignoring variation in task lag. When the task-recency variable was scaled continuously, all 4 experiments instead showed additivity between expectancy and recency. The results indicated that expectancy and recency influence different stages of mental processing. One specific possibility (the configuration-execution model) is that task expectancy affects the time required to configure upcoming central operations, whereas task recency affects the time required to actually execute those central operations.

Neuronal intrinsic regenerative capacity: The impact of microtubule organization and axonal transport.

PubMed

Murillo, Blanca; Sousa, Mónica Mendes

2018-05-08

In the adult vertebrate central nervous system, axons generally fail to regenerate. In contrast, peripheral nervous system axons are able to form a growth cone and regenerate upon lesion. Among the multiple intrinsic mechanisms leading to the formation of a new growth cone and to successful axon regrowth, cytoskeleton organization and dynamics is central. Here we discuss how multiple pathways that define the regenerative capacity converge into the regulation of the axonal microtubule cytoskeleton and transport. We further explore the use of dorsal root ganglion neurons as a model to study the neuronal regenerative ability. Finally, we address some of the unanswered questions in the field, including the mechanisms by which axonal transport might be modulated by injury, and the relationship between microtubule organization, dynamics, and axonal transport. © 2018 Wiley Periodicals, Inc. Develop Neurobiol, 2018. © 2018 Wiley Periodicals, Inc.

Nucleophilic substitution at silicon (SN2@Si) via a central reaction barrier.

PubMed

Bento, A Patrícia; Bickelhaupt, F Matthias

2007-03-16

It is textbook knowledge that nucleophilic substitution at carbon (SN2@C) proceeds via a central reaction barrier which disappears in the corresponding nucleophilic substitution reaction at silicon (SN2@Si). Here, we address the question why the central barrier disappears from SN2@C to SN2@Si despite the fact that these processes are isostructural and isoelectronic. To this end, we have explored and analyzed the potential energy surfaces (PES) of various Cl-+CR3Cl (R=H, CH3) and Cl-+SiR3Cl model reactions (R=H, CH3, C2H5, and OCH3). Our results show that the nature of the SN2 reaction barrier is in essence steric, but that it can be modulated by electronic factors. Thus, simply by increasing the steric demand of the substituents R around the silicon atom, the SN2@Si mechanism changes from its regular single-well PES (with a stable intermediate transition complex, TC), via a triple-well PES (with a pre- and a post-TS before and after the central TC), to a double-well PES (with a TS; R=OCH3), which is normally encountered for SN2@C reactions.

An official American Thoracic Society research statement: comparative effectiveness research in pulmonary, critical care, and sleep medicine.

PubMed

Carson, Shannon S; Goss, Christopher H; Patel, Sanjay R; Anzueto, Antonio; Au, David H; Elborn, Stuart; Gerald, Joe K; Gerald, Lynn B; Kahn, Jeremy M; Malhotra, Atul; Mularski, Richard A; Riekert, Kristin A; Rubenfeld, Gordon D; Weaver, Terri E; Krishnan, Jerry A

2013-11-15

Comparative effectiveness research (CER) is intended to inform decision making in clinical practice, and is central to patient-centered outcomes research (PCOR). To summarize key aspects of CER definitions and provide examples highlighting the complementary nature of efficacy and CER studies in pulmonary, critical care, and sleep medicine. An ad hoc working group of the American Thoracic Society with experience in clinical trials, health services research, quality improvement, and behavioral sciences in pulmonary, critical care, and sleep medicine was convened. The group used an iterative consensus process, including a review by American Thoracic Society committees and assemblies. The traditional efficacy paradigm relies on clinical trials with high internal validity to evaluate interventions in narrowly defined populations and in research settings. Efficacy studies address the question, "Can it work in optimal conditions?" The CER paradigm employs a wide range of study designs to understand the effects of interventions in clinical settings. CER studies address the question, "Does it work in practice?" The results of efficacy and CER studies may or may not agree. CER incorporates many attributes of outcomes research and health services research, while placing greater emphasis on meeting the expressed needs of nonresearcher stakeholders (e.g., patients, clinicians, and others). CER complements traditional efficacy research by placing greater emphasis on the effects of interventions in practice, and developing evidence to address the needs of the many stakeholders involved in health care decisions. Stakeholder engagement is an important component of CER.

Mitochondrial Function in Sepsis

PubMed Central

Arulkumaran, Nishkantha; Deutschman, Clifford S.; Pinsky, Michael R.; Zuckerbraun, Brian; Schumacker, Paul T.; Gomez, Hernando; Gomez, Alonso; Murray, Patrick; Kellum, John A.

2015-01-01

Mitochondria are an essential part of the cellular infrastructure, being the primary site for high energy adenosine triphosphate (ATP) production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered and end organ dysfunction not only common but predictive of long term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used as both a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide. PMID:26871665

MITOCHONDRIAL FUNCTION IN SEPSIS.

PubMed

Arulkumaran, Nishkantha; Deutschman, Clifford S; Pinsky, Michael R; Zuckerbraun, Brian; Schumacker, Paul T; Gomez, Hernando; Gomez, Alonso; Murray, Patrick; Kellum, John A

2016-03-01

Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long-term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used both as a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide.

Preparing engineers for the challenges of community engagement

NASA Astrophysics Data System (ADS)

Harsh, Matthew; Bernstein, Michael J.; Wetmore, Jameson; Cozzens, Susan; Woodson, Thomas; Castillo, Rafael

2017-11-01

Despite calls to address global challenges through community engagement, engineers are not formally prepared to engage with communities. Little research has been done on means to address this 'engagement gap' in engineering education. We examine the efficacy of an intensive, two-day Community Engagement Workshop for engineers, designed to help engineers better look beyond technology, listen to and learn from people, and empower communities. We assessed the efficacy of the workshop in a non-experimental pre-post design using a questionnaire and a concept map. Questionnaire results indicate participants came away better able to ask questions more broadly inclusive of non-technological dimensions of engineering projects. Concept map results indicate participants have a greater understanding of ways social factors shape complex material systems after completing the programme. Based on the workshop's strengths and weaknesses, we discuss the potential of expanding and supplementing the programme to help engineers account for social aspects central to engineered systems.

Stuck in the middle: the impact of collaborative interprofessional communication on patient expectations.

PubMed

Stewart, Michael Adrian

2018-01-01

A central aim of modern day healthcare is to deliver a high quality, patient-centred service that addresses the expectations of its service users. However, mounting research evidence highlights a lack of patient satisfaction across a range of healthcare settings, with an overwhelming proportion of complaints relating to interprofessional communication. The link between interprofessional miscommunication and poor patient outcomes has been well documented. All too often, patients are left feeling stuck in the middle between opposing opinions, differing diagnoses and conflicting clinical outlooks. This article aims to highlight the issues surrounding interprofessional communication in healthcare, at the same time as addressing the potential facilitators and barriers for developing improved collaborative links between healthcare providers. Several key questions will be considered: (i) what are the underlying causes of interprofessional miscommunication; (ii) what do patients expect from healthcare professionals; and (iii) how might we reduce the risk of miscommunication and develop interprofessional collaboration?

Informatic parcellation of the network involved in the computation of subjective value

PubMed Central

Rangel, Antonio

2014-01-01

Understanding how the brain computes value is a basic question in neuroscience. Although individual studies have driven this progress, meta-analyses provide an opportunity to test hypotheses that require large collections of data. We carry out a meta-analysis of a large set of functional magnetic resonance imaging studies of value computation to address several key questions. First, what is the full set of brain areas that reliably correlate with stimulus values when they need to be computed? Second, is this set of areas organized into dissociable functional networks? Third, is a distinct network of regions involved in the computation of stimulus values at decision and outcome? Finally, are different brain areas involved in the computation of stimulus values for different reward modalities? Our results demonstrate the centrality of ventromedial prefrontal cortex (VMPFC), ventral striatum and posterior cingulate cortex (PCC) in the computation of value across tasks, reward modalities and stages of the decision-making process. We also find evidence of distinct subnetworks of co-activation within VMPFC, one involving central VMPFC and dorsal PCC and another involving more anterior VMPFC, left angular gyrus and ventral PCC. Finally, we identify a posterior-to-anterior gradient of value representations corresponding to concrete-to-abstract rewards. PMID:23887811

Potential impacts of historical disturbance on green turtle health in the unique & protected marine ecosystem of Palmyra Atoll (Central Pacific).

PubMed

McFadden, Katherine W; Gómez, Andrés; Sterling, Eleanor J; Naro-Maciel, Eugenia

2014-12-15

Palmyra Atoll, in the Central Pacific, is a unique marine ecosystem because of its remarkably intact food web and limited anthropogenic stressors. However during World War II the atoll was structurally reconfigured into a military installation and questions remain whether this may have impacted the health of the atoll's ecosystems and species. To address the issue we assessed green sea turtle (n=157) health and exposure to contaminants at this foraging ground from 2008 to 2012. Physical exams were performed and blood was sampled for testosterone analysis, plasma biochemistry analysis, hematology and heavy metal exposure. Hematological and plasma chemistries were consistent with concentrations reported for healthy green turtles. Heavy metal screenings revealed low concentrations of most metals, except for high concentrations of iron and aluminum. Body condition indices showed that <1% of turtles had poor body condition. In this study, we provide the first published blood values for a markedly healthy sea turtle population at a remote Central Pacific Atoll. Published by Elsevier Ltd.

Ghrelin

PubMed Central

Müller, T.D.; Nogueiras, R.; Andermann, M.L.; Andrews, Z.B.; Anker, S.D.; Argente, J.; Batterham, R.L.; Benoit, S.C.; Bowers, C.Y.; Broglio, F.; Casanueva, F.F.; D'Alessio, D.; Depoortere, I.; Geliebter, A.; Ghigo, E.; Cole, P.A.; Cowley, M.; Cummings, D.E.; Dagher, A.; Diano, S.; Dickson, S.L.; Diéguez, C.; Granata, R.; Grill, H.J.; Grove, K.; Habegger, K.M.; Heppner, K.; Heiman, M.L.; Holsen, L.; Holst, B.; Inui, A.; Jansson, J.O.; Kirchner, H.; Korbonits, M.; Laferrère, B.; LeRoux, C.W.; Lopez, M.; Morin, S.; Nakazato, M.; Nass, R.; Perez-Tilve, D.; Pfluger, P.T.; Schwartz, T.W.; Seeley, R.J.; Sleeman, M.; Sun, Y.; Sussel, L.; Tong, J.; Thorner, M.O.; van der Lely, A.J.; van der Ploeg, L.H.T.; Zigman, J.M.; Kojima, M.; Kangawa, K.; Smith, R.G.; Horvath, T.; Tschöp, M.H.

2015-01-01

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism. PMID:26042199

Fragrance sensitisers: Is inhalation an allergy risk?

PubMed

Basketter, David; Kimber, Ian

2015-12-01

It is well established that some fragrance substances have the potential to cause skin sensitisation associated with the development of allergic contact dermatitis (ACD). Fragrances are invariably relatively volatile leading to the consideration that inhalation of fragrances might be a relevant route for either the induction of allergic sensitisation or the elicitation of allergic reactions. Moreover, there has been increasing recognition that allergic sensitisation of the respiratory tract can be induced by topical exposure to certain chemical allergens. Here the central question addressed is whether inhalation exposure to fragrance allergens has the potential to cause skin and/or respiratory sensitisation via the respiratory tract, or elicit allergic symptoms in those already sensitised. In addressing those questions, the underlying immunobiology of skin and respiratory sensitisation to chemicals has been reviewed briefly, and the relevant experimental and clinical evidence considered. The essential mechanistic differences between skin and respiratory allergy appear consistent with other sources of information, including the phenomenon of ACD that can arise from topical exposure to airborne allergens, but in the absence of accompanying respiratory effects. The conclusion is that, in contrast to topical exposure (including topical exposure to airborne material), inhalation of fragrance sensitisers does not represent a health risk with respect to allergy. Copyright © 2015 Elsevier Inc. All rights reserved.

Sovereignty Under Siege: Drug Trafficking and State Capacity in the Caribbean and Central America

DTIC Science & Technology

2016-06-01

CARIBBEAN AND CENTRAL AMERICA 5. FUNDING NUMBERS 6. AUTHOR(S) Ryan Thomas King 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval...Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A...trafficking organizations have increased their prominence throughout the Caribbean and Central America. These organizations undermine the rule of law

Privacy Questions from Practicing School Nurses

ERIC Educational Resources Information Center

Bergren, Martha Dewey

2004-01-01

This Question and Answer (Q&A) article addresses practice issues related to school health records and school nursing documentation that were posed by school nurses in the field. Specifically, the questions addressed concern the following: education records, medication privacy issues, sharing of sensitive health information, privacy of…

The Agua Salud Project, Central Panama

NASA Astrophysics Data System (ADS)

Stallard, R. F.; Elsenbeer, H.; Ogden, F. L.; Hall, J. S.

2007-12-01

The Agua Salud Project utilizes the Panama Canal's central role in world commerce to focus global attention on the ecosystem services provided by tropical forests. It will be the largest field experiment of its kind in the tropics aimed at quantifying the environmental services (water, carbon, and biodiversity) provided by tropical forests. The Agua Salud Watershed is our principal field site. This watershed and the headwaters of several adjacent rivers include both protected mature forests and a wide variety of land uses that are typical of rural Panama. Experiments at the scale of entire catchments will permit complete water and carbon inventories and exchanges for different landscape uses. The following questions will be addressed: (1) How do landscape treatments and management approaches affect ecosystem services such as carbon storage, water quality and quantity, dry- season water supply, and biodiversity? (2) Can management techniques be designed to optimize forest production along with ecosystem services during reforestation? (3) Do different tree planting treatments and landscape management approaches influence groundwater storage, which is thought to be critical to maintaining dry-season flow, thus insuring the full operation of the Canal during periods of reduced rainfall and severe climatic events such as El Niño. In addition we anticipate expanding this project to address biodiversity, social, and economic values of these forests.

Blending Education and Polymer Science: Semi Automated Creation of a Thermodynamic Property Database.

PubMed

Tchoua, Roselyne B; Qin, Jian; Audus, Debra J; Chard, Kyle; Foster, Ian T; de Pablo, Juan

2016-09-13

Structured databases of chemical and physical properties play a central role in the everyday research activities of scientists and engineers. In materials science, researchers and engineers turn to these databases to quickly query, compare, and aggregate various properties, thereby allowing for the development or application of new materials. The vast majority of these databases have been generated manually, through decades of labor-intensive harvesting of information from the literature; yet, while there are many examples of commonly used databases, a significant number of important properties remain locked within the tables, figures, and text of publications. The question addressed in our work is whether, and to what extent, the process of data collection can be automated. Students of the physical sciences and engineering are often confronted with the challenge of finding and applying property data from the literature, and a central aspect of their education is to develop the critical skills needed to identify such data and discern their meaning or validity. To address shortcomings associated with automated information extraction, while simultaneously preparing the next generation of scientists for their future endeavors, we developed a novel course-based approach in which students develop skills in polymer chemistry and physics and apply their knowledge by assisting with the semi-automated creation of a thermodynamic property database.

Blending Education and Polymer Science: Semiautomated Creation of a Thermodynamic Property Database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tchoua, Roselyne B.; Qin, Jian; Audus, Debra J.

Structured databases of chemical and physical properties play a central role in the everyday research activities of scientists and engineers. In materials science, researchers and engineers turn to these databases to quickly query, compare, and aggregate various properties, thereby allowing for the development or application of new materials. The vast majority of these databases have been generated manually, through decades of labor-intensive harvesting of information from the literature, yet while there are many examples of commonly used databases, a significant number of important properties remain locked within the tables, figures, and text of publications. The question addressed in our workmore » is whether and to what extent the process of data collection can be automated. Students of the physical sciences and engineering are often confronted with the challenge of finding and applying property data from the literature, and a central aspect of their education is to develop the critical skills needed to identify such data and discern their meaning or validity. To address shortcomings associated with automated information extraction while simultaneously preparing the next generation of scientists for their future endeavors, we developed a novel course-based approach in which students develop skills in polymer chemistry and physics and apply their knowledge by assisting with the semiautomated creation of a thermodynamic property database.« less

On the Question of an Identity Status Category Order: Rasch Model Step and Scale Statistics Used to Identify Category Order

ERIC Educational Resources Information Center

Al-Owidha, Amjed; Green, Kathy E.; Kroger, Jane

2009-01-01

The question of whether or not a developmental continuum underlies James Marcia's identity statuses has been a topic of debate among identity researchers for nearly 20 years. This study addressed the prefatory question of whether the identity statuses can be empirically ordered in a theoretically optimal way. This question was addressed via use of…

Inconclusive evidence of Juniperus virginiana recovery following sulfur pollution reductions

Treesearch

Paul G. Schaberg; Gary J. Hawley; Shelly A. Rayback; Joshua M. Halman; Alexandra M. Kosiba

2014-01-01

Thomas et al. (1) address a question of great scientific interest: have pollution reductions mandated by the Clean Air Act improved forest health and productivity? Although answers to this question are of great importance, various aspects of this work limit its ability to address this question.

From Latifundia to Central Planning and Onward to Agribusiness: A Rejoinder to Joachim Singelmann's Presidential Address on "From Central Planning to Markets"

ERIC Educational Resources Information Center

Szelenyi, Ivan

2011-01-01

This article presents the author's rejoinder to Joachim Singelmann's presidential address on "From Central Planning to Markets." Joachim Singelmann in his presidential address challenged the received wisdom: socialism was doomed to fail; during the market transition all of its basic institutions had to be abolished and replaced by the…

A Typology of Adult Literacy Instructional Approaches

ERIC Educational Resources Information Center

Beder, Hal; Lipnevich, Anastasiya; Robinson-Geller, Perrine

2007-01-01

This study addresses the primary question, "What instructional approaches typify adult literacy education in the United States?" as well as several secondary questions. To address the primary question, a survey was developed and responses were received from 598 adult literacy teachers in 12 states. When the data were subjected to factor analysis,…

Records--The Achilles' Heel of School Nursing: Answers to Bothersome Questions

ERIC Educational Resources Information Center

Schwab, Nadine C.; Pohlman, Katherine J.

2004-01-01

This article addresses practice issues related to school health records and school nursing documentation. Because the issues have been posed by practicing school nurses, the article is in Question and Answer (Q&A) format. Specifically, the questions addressed concern the following: ownership and storage location of student health records when…

Quality of Prostate Cancer Treatment Information on Cancer Center Websites.

PubMed

Dulaney, Caleb; Barrett, Olivia Claire; Rais-Bahrami, Soroush; Wakefield, Daniel; Fiveash, John; Dobelbower, Michael

2016-04-20

Cancer center websites are trusted sources of internet information about treatment options for prostate cancer. The quality of information on these websites is unknown. The objective of this study was to evaluate the quality of information on cancer center websites addressing prostate cancer treatment options, outcomes, and toxicity. We evaluated the websites of all National Cancer Institute-designated cancer centers to determine if sufficient information was provided to address eleven decision-specific knowledge questions from the validated Early Prostate Cancer Treatment Decision Quality Instrument. We recorded the number of questions addressed, the number of clicks to reach the prostate cancer-specific webpage, evaluation time, and Spanish and mobile accessibility. Correlation between evaluation time and questions addressed were calculated using the Pearson coefficient. Sixty-three websites were reviewed. Eighty percent had a prostate cancer-specific webpage reached in a median of three clicks. The average evaluation time was 6.5 minutes. Information was available in Spanish on 24% of sites and 59% were mobile friendly. Websites provided sufficient information to address, on average, 19% of questions. No website addressed all questions. Evaluation time correlated with the number of questions addressed (R(2) = 0.42, p < 0.001). Cancer center websites provide insufficient information for men with localized prostate cancer due to a lack of information about and direct comparison of specific treatment outcomes and toxicities. Information is also less accessible in Spanish and on mobile devices. These data can be used to improve the quality and accessibility of prostate cancer treatment information on cancer center websites.

Inverse scattering transform analysis of rogue waves using local periodization procedure

NASA Astrophysics Data System (ADS)

Randoux, Stéphane; Suret, Pierre; El, Gennady

2016-07-01

The nonlinear Schrödinger equation (NLSE) stands out as the dispersive nonlinear partial differential equation that plays a prominent role in the modeling and understanding of the wave phenomena relevant to many fields of nonlinear physics. The question of random input problems in the one-dimensional and integrable NLSE enters within the framework of integrable turbulence, and the specific question of the formation of rogue waves (RWs) has been recently extensively studied in this context. The determination of exact analytic solutions of the focusing 1D-NLSE prototyping RW events of statistical relevance is now considered as the problem of central importance. Here we address this question from the perspective of the inverse scattering transform (IST) method that relies on the integrable nature of the wave equation. We develop a conceptually new approach to the RW classification in which appropriate, locally coherent structures are specifically isolated from a globally incoherent wave train to be subsequently analyzed by implementing a numerical IST procedure relying on a spatial periodization of the object under consideration. Using this approach we extend the existing classifications of the prototypes of RWs from standard breathers and their collisions to more general nonlinear modes characterized by their nonlinear spectra.

Inverse scattering transform analysis of rogue waves using local periodization procedure

PubMed Central

Randoux, Stéphane; Suret, Pierre; El, Gennady

2016-01-01

The nonlinear Schrödinger equation (NLSE) stands out as the dispersive nonlinear partial differential equation that plays a prominent role in the modeling and understanding of the wave phenomena relevant to many fields of nonlinear physics. The question of random input problems in the one-dimensional and integrable NLSE enters within the framework of integrable turbulence, and the specific question of the formation of rogue waves (RWs) has been recently extensively studied in this context. The determination of exact analytic solutions of the focusing 1D-NLSE prototyping RW events of statistical relevance is now considered as the problem of central importance. Here we address this question from the perspective of the inverse scattering transform (IST) method that relies on the integrable nature of the wave equation. We develop a conceptually new approach to the RW classification in which appropriate, locally coherent structures are specifically isolated from a globally incoherent wave train to be subsequently analyzed by implementing a numerical IST procedure relying on a spatial periodization of the object under consideration. Using this approach we extend the existing classifications of the prototypes of RWs from standard breathers and their collisions to more general nonlinear modes characterized by their nonlinear spectra. PMID:27385164

From single steps to mass migration: the problem of scale in the movement ecology of the Serengeti wildebeest.

PubMed

Torney, Colin J; Hopcraft, J Grant C; Morrison, Thomas A; Couzin, Iain D; Levin, Simon A

2018-05-19

A central question in ecology is how to link processes that occur over different scales. The daily interactions of individual organisms ultimately determine community dynamics, population fluctuations and the functioning of entire ecosystems. Observations of these multiscale ecological processes are constrained by various technological, biological or logistical issues, and there are often vast discrepancies between the scale at which observation is possible and the scale of the question of interest. Animal movement is characterized by processes that act over multiple spatial and temporal scales. Second-by-second decisions accumulate to produce annual movement patterns. Individuals influence, and are influenced by, collective movement decisions, which then govern the spatial distribution of populations and the connectivity of meta-populations. While the field of movement ecology is experiencing unprecedented growth in the availability of movement data, there remain challenges in integrating observations with questions of ecological interest. In this article, we present the major challenges of addressing these issues within the context of the Serengeti wildebeest migration, a keystone ecological phenomena that crosses multiple scales of space, time and biological complexity.This article is part of the theme issue 'Collective movement ecology'. © 2018 The Author(s).

XVI European Charcot Foundation Lecture: Nutrition and environment, can MS be prevented?

PubMed Central

Simon, Kelly Claire; Munger, Kassandra L; Ascherio, Alberto

2012-01-01

Multiple sclerosis is a relatively common debilitating neurologic disease that affects people in early adulthood. While the characteristic pathology of MS has been well described, the etiology of the disease is not well understood, despite decades of research and the identification of strong genetic and environmental candidates for susceptibility. A question central to all diseases, but posed specifically for MS at the XVI European Charcot Foundation Lecture, was ‘Can MS be prevented?’ To address this question, we have evaluated the available data regarding nutritional and environmental factors that may be related to MS susceptibility and suggest the extent to which a potential intervention may reduce disease burden. It is our opinion that intervention, particularly supplementation with vitamin D, could have a dramatic impact on disease prevalence. Understanding that any intervention or behavioral modification will surely act in the context of genetic susceptibility and unidentified stochastic events, it is likely that not all MS is ‘preventable’. Epidemiologic observation has provided key insights into environmental and nutritional factors that may alter one’s susceptibility to MS, however, there are still many questions in unraveling the etiology of this complex disease. PMID:21975017

Encoding, Memory, and Transcoding Deficits in Childhood Apraxia of Speech

PubMed Central

Shriberg, Lawrence D.; Lohmeier, Heather L.; Strand, Edythe A.; Jakielski, Kathy J.

2013-01-01

Purpose A central question in Childhood Apraxia of Speech (CAS) is whether the core phenotype is limited to transcoding (planning/programming) deficits or if speakers with CAS also have deficits in auditory-perceptual encoding (representational) and/or memory (storage and retrieval of representations) processes. We addressed this and other questions using responses to the Syllable Repetition Task (SRT: Shriberg et al., 2009). Method The SRT was administered to 369 individuals in four groups: (a) Typical Speech-Language (119), (b) Speech Delay-Typical Language (140), (c) Speech Delay-Language Impairment (70), and (d) idiopathic or neurogenetic CAS (40). Results CAS participants had significantly lower SRT competence, encoding, memory, and transcoding scores than controls. They were 8.3 times more likely than controls to have SRT transcoding scores below 80%. Conclusions Speakers with CAS have speech processing deficits in encoding, memory, and transcoding. The SRT currently has moderate diagnostic accuracy to identify transcoding deficits, the signature feature of CAS. PMID:22489736

Chromosomal polymorphism in mammals: an evolutionary perspective.

PubMed

Dobigny, Gauthier; Britton-Davidian, Janice; Robinson, Terence J

2017-02-01

Although chromosome rearrangements (CRs) are central to studies of genome evolution, our understanding of the evolutionary consequences of the early stages of karyotypic differentiation (i.e. polymorphism), especially the non-meiotic impacts, is surprisingly limited. We review the available data on chromosomal polymorphisms in mammals so as to identify taxa that hold promise for developing a more comprehensive understanding of chromosomal change. In doing so, we address several key questions: (i) to what extent are mammalian karyotypes polymorphic, and what types of rearrangements are principally involved? (ii) Are some mammalian lineages more prone to chromosomal polymorphism than others? More specifically, do (karyotypically) polymorphic mammalian species belong to lineages that are also characterized by past, extensive karyotype repatterning? (iii) How long can chromosomal polymorphisms persist in mammals? We discuss the evolutionary implications of these questions and propose several research avenues that may shed light on the role of chromosome change in the diversification of mammalian populations and species. © 2015 Cambridge Philosophical Society.

Lost in translation. Homer in English; the patient's story in medicine.

PubMed

Marshall, Robert J; Bleakley, Alan

2013-06-01

In a series of previous articles, we have considered how we might reconceptualise central themes in medicine and medical education through 'thinking with Homer'. This has involved using textual approaches, scenes and characters from the Iliad and Odyssey for rethinking what is a 'communication skill', and what do we mean by 'empathy' in medical practice; in what sense is medical practice formulaic, like a Homeric 'song'; and what is lyrical about medical practice. Our approach is not to historicise medicine and medical education, but to use thinking with Homer as a medium and metaphor for questioning the habitual and the taken-for-granted in contemporary practice. In this article, we tackle the complex theme of 'translation'. We use the lens of translation studies to examine the process of turning the patient's story into medical language. We address the questions: what makes a 'good' translation? What are the consequences of mistranslation and poor translation? And, while things are inevitably lost in translation, does this matter?

Do metacognitive judgments alter memory performance beyond the benefits of retrieval practice? A comment on and replication attempt of Dougherty, Scheck, Nelson, and Narens (2005).

PubMed

Dougherty, Michael R; Robey, Alison M; Buttaccio, Daniel

2018-05-01

A central question in the metacognitive literature concerns whether the act of making a metacognitive judgment alters one's memory for the information about which the judgment was made. Dougherty, Scheck, Nelson, and Narens (2005, Memory & Cognition, 33(6), 1096-1115) attempted to address this question by having participants make either retrospective confidence judgments (RCJs; i.e., evaluations of past retrieval success), judgments of learning (JOLs; i.e., predictions of future retrieval success), or no explicit judgments. When comparing final retrieval accuracy they found that accuracy was greater for items where participants had made JOLs compared with items that received RCJs or no judgment, suggesting that simply making a JOL can improve later memory performance. The present article presents results from four separate replication attempts that fail to duplicate this finding. Combined results provide compelling evidence that making a metacognitive judgment, regardless of the type, has no impact on later memory performance above and beyond retrieval practice.

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult.

PubMed

Herrlinger, Stephanie A; Shao, Qiang; Ma, Li; Brindley, Melinda; Chen, Jian-Fu

2018-04-26

The Zika virus (ZIKV) is a flavivirus currently endemic in North, Central, and South America. It is now established that the ZIKV can cause microcephaly and additional brain abnormalities. However, the mechanism underlying the pathogenesis of ZIKV in the developing brain remains unclear. Intracerebral surgical methods are frequently used in neuroscience research to address questions about both normal and abnormal brain development and brain function. This protocol utilizes classical surgical techniques and describes methods that allow one to model ZIKV-associated human neurological disease in the mouse nervous system. While direct brain inoculation does not model the normal mode of virus transmission, the method allows investigators to ask targeted questions concerning the consequence after ZIKV infection of the developing brain. This protocol describes embryonic, neonatal, and adult stages of intraventricular inoculation of ZIKV. Once mastered, this method can become a straightforward and reproducible technique that only takes a few hours to perform.

Landauer in the Age of Synthetic Biology: Energy Consumption and Information Processing in Biochemical Networks

NASA Astrophysics Data System (ADS)

Mehta, Pankaj; Lang, Alex H.; Schwab, David J.

2016-03-01

A central goal of synthetic biology is to design sophisticated synthetic cellular circuits that can perform complex computations and information processing tasks in response to specific inputs. The tremendous advances in our ability to understand and manipulate cellular information processing networks raises several fundamental physics questions: How do the molecular components of cellular circuits exploit energy consumption to improve information processing? Can one utilize ideas from thermodynamics to improve the design of synthetic cellular circuits and modules? Here, we summarize recent theoretical work addressing these questions. Energy consumption in cellular circuits serves five basic purposes: (1) increasing specificity, (2) manipulating dynamics, (3) reducing variability, (4) amplifying signal, and (5) erasing memory. We demonstrate these ideas using several simple examples and discuss the implications of these theoretical ideas for the emerging field of synthetic biology. We conclude by discussing how it may be possible to overcome these limitations using "post-translational" synthetic biology that exploits reversible protein modification.

Telemedicine broadening access to care for complex cases.

PubMed

Jue, Joshua S; Spector, Sydney A; Spector, Seth A

2017-12-01

Surgical and nonsurgical specialists are highly centralized, making access to high-quality care difficult for many Americans. We explored the feasibility, benefits, preliminary outcomes, and patient satisfaction with a new type of health visit, in which a surgical oncologist used video telecommunication to manage and treat complex cancer diseases, including patients with severe comorbidities. Patients visited local VA medical centers throughout Florida to engage in video telecommunication visits with a centralized surgical oncologist in Miami, who directed their oncology treatment. The average length of stay and rate of unplanned readmission were calculated within each organ. The total mileage saved was calculated by subtracting the distance between the patient's home address and the local VA from the distance between the patient's home address and the Miami VA. Travel costs were determined by the VA's reimbursement of $0.415/mile for health-related travel and reimbursement of $150.00 for an overnight hotel stay. A Likert scale with both positively and negatively keyed questions was used to assess patient satisfaction. In 24 mo, seven unplanned readmissions occurred among 195 operations. Patients experienced an 80.7% reduction in travel distance and saved a total of 213,007.58 miles by visiting their local VA instead of the Miami VA. Survey results indicate that 86% of patients believed that the telemedicine program made medical care more accessible. The Specialist-Directed Telemedicine Model can save patients substantial time and money by not traveling to centralized areas, while delivering greater continuity of care and patient satisfaction. Copyright © 2017 Elsevier Inc. All rights reserved.

Application of imaging spectrometer data to the Kings-Kaweah ophiolite melange

NASA Technical Reports Server (NTRS)

Mustard, John F.; Pieters, Carle M.

1988-01-01

The Kings-Kaweah ophiolite melange in east-central California is thought to be an obducted oceanic fracture zone and provides the rare opportunity to examine in detail the complex nature of this type of terrain. It is anticipated that the distribution and abundance of components in the melange can be used to determine the relative importance of geologic processes responsible for the formation of fracture zone crust. Laboratory reflectance spectra of field samples indicate that the melange components have distinct, diagnostic absorptions at visible to near-infrared wavelengths. The spatial and spectral resolution of AVIRIS is ideally suited for addressing important scientific questions concerning the Kings-Kaweah ophiolite melange and fracture zones in general.

Interactions Between Nutrition and Infections With Haemonchus contortus and Related Gastrointestinal Nematodes in Small Ruminants.

PubMed

Hoste, H; Torres-Acosta, J F J; Quijada, J; Chan-Perez, I; Dakheel, M M; Kommuru, D S; Mueller-Harvey, I; Terrill, T H

2016-01-01

Interactions between host nutrition and feeding behaviour are central to understanding the pathophysiological consequences of infections of the digestive tract with parasitic nematodes. The manipulation of host nutrition provides useful options to control gastrointestinal nematodes as a component of an integrated strategy. Focussed mainly on the Haemonchus contortus infection model in small ruminants, this chapter (1) illustrates the relationship between quantitative (macro- and micro-nutrients) and qualitative (plant secondary metabolites) aspects of host nutrition and nematode infection, and (2) shows how basic studies aimed at addressing some generic questions can help to provide solutions, despite the considerable diversity of epidemiological situations and breeding systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

Spectral Collocation Time-Domain Modeling of Diffractive Optical Elements

NASA Astrophysics Data System (ADS)

Hesthaven, J. S.; Dinesen, P. G.; Lynov, J. P.

1999-11-01

A spectral collocation multi-domain scheme is developed for the accurate and efficient time-domain solution of Maxwell's equations within multi-layered diffractive optical elements. Special attention is being paid to the modeling of out-of-plane waveguide couplers. Emphasis is given to the proper construction of high-order schemes with the ability to handle very general problems of considerable geometric and material complexity. Central questions regarding efficient absorbing boundary conditions and time-stepping issues are also addressed. The efficacy of the overall scheme for the time-domain modeling of electrically large, and computationally challenging, problems is illustrated by solving a number of plane as well as non-plane waveguide problems.

Erosional and depositional history of central Chryse Planitia

NASA Technical Reports Server (NTRS)

Crumpler, L. S.

1992-01-01

This map uses high resolution image data to assess the detailed depositional and erosional history of part of Chryse Planitia. This area is significant to the study of the global geology of Mars because it represents one of only two areas on the martian surface where planetary geologic mapping is assisted with 'ground truth.' In this case the ground truth was provided by Viking Lander 1. Additional questions addressed in this study are concerned with the following: the geologic context of the regional plains surface and the local surface of the Viking Lander 1 site; and the relative influence of volcanic, sedimentary, impact, aeolian, and tectonic processes at the regional and local scales.

Spatial-frequency cutoff requirements for pattern recognition in central and peripheral vision

PubMed Central

Kwon, MiYoung; Legge, Gordon E.

2011-01-01

It is well known that object recognition requires spatial frequencies exceeding some critical cutoff value. People with central scotomas who rely on peripheral vision have substantial difficulty with reading and face recognition. Deficiencies of pattern recognition in peripheral vision, might result in higher cutoff requirements, and may contribute to the functional problems of people with central-field loss. Here we asked about differences in spatial-cutoff requirements in central and peripheral vision for letter and face recognition. The stimuli were the 26 letters of the English alphabet and 26 celebrity faces. Each image was blurred using a low-pass filter in the spatial frequency domain. Critical cutoffs (defined as the minimum low-pass filter cutoff yielding 80% accuracy) were obtained by measuring recognition accuracy as a function of cutoff (in cycles per object). Our data showed that critical cutoffs increased from central to peripheral vision by 20% for letter recognition and by 50% for face recognition. We asked whether these differences could be accounted for by central/peripheral differences in the contrast sensitivity function (CSF). We addressed this question by implementing an ideal-observer model which incorporates empirical CSF measurements and tested the model on letter and face recognition. The success of the model indicates that central/peripheral differences in the cutoff requirements for letter and face recognition can be accounted for by the information content of the stimulus limited by the shape of the human CSF, combined with a source of internal noise and followed by an optimal decision rule. PMID:21854800

Some steps toward a central theory of ecosystem dynamics.

PubMed

Ulanowicz, Robert E

2003-12-01

Ecology is said by many to suffer for want of a central theory, such as Newton's laws of motion provide for classical mechanics or Schroedinger's wave equation provides for quantum physics. From among a plurality of contending laws to govern ecosystem behavior, the principle of increasing ascendency shows some early promise of being able to address the major questions asked of a theory of ecosystems, including, "How do organisms come to be distributed in time and space?, what accounts for the log-normal distribution of species numbers?, and how is the diversity of ecosystems related to their stability, resilience and persistence?" While some progress has been made in applying the concept of ascendency to the first issue, more work is needed to articulate exactly how it relates to the latter two. Accordingly, seven theoretical tasks are suggested that could help to establish these connections and to promote further consideration of the ascendency principle as the kernel of a theory of ecosystems.

Navigating north: how body mass and winds shape avian flight behaviours across a North American migratory flyway.

PubMed

Horton, Kyle G; Van Doren, Benjamin M; La Sorte, Frank A; Fink, Daniel; Sheldon, Daniel; Farnsworth, Andrew; Kelly, Jeffrey F

2018-05-07

The migratory patterns of birds have been the focus of ecologists for millennia. What behavioural traits underlie these remarkably consistent movements? Addressing this question is central to advancing our understanding of migratory flight strategies and requires the integration of information across levels of biological organisation, e.g. species to communities. Here, we combine species-specific observations from the eBird citizen-science database with observations aggregated from weather surveillance radars during spring migration in central North America. Our results confirm a core prediction of migration theory at an unprecedented national scale: body mass predicts variation in flight strategies across latitudes, with larger-bodied species flying faster and compensating more for wind drift. We also find evidence that migrants travelling northward earlier in the spring increasingly compensate for wind drift at higher latitudes. This integration of information across biological scales provides new insight into patterns and determinants of broad-scale flight strategies of migratory birds. © 2018 John Wiley & Sons Ltd/CNRS.

Teaching in hunter–gatherer infancy

PubMed Central

Hewlett, Barry S.; Roulette, Casey J.

2016-01-01

A debate exists as to whether teaching is part of human nature and central to understanding culture or whether it is a recent invention of Western, Educated, Industrial, Rich, Democratic cultures. Some social–cultural anthropologists and cultural psychologists indicate teaching is rare in small-scale cultures while cognitive psychologists and evolutionary biologists indicate it is universal and key to understanding human culture. This study addresses the following questions: Does teaching of infants exist in hunter–gatherers? If teaching occurs in infancy, what skills or knowledge is transmitted by this process, how often does it occur and who is teaching? The study focuses on late infancy because cognitive psychologists indicate that one form of teaching, called natural pedagogy, emerges at this age. Videotapes of Aka hunter–gatherer infants were used to evaluate whether or not teaching exists among Aka hunter–gatherers of central Africa. The study finds evidence of multiple forms of teaching, including natural pedagogy, that are used to enhance learning of a variety of skills and knowledge. PMID:26909166

Guiding the Process of Culturally Competent Care With Hispanic Patients: A Grounded Theory Study.

PubMed

Sobel, Linda L; Metzler Sawin, Erika

2016-05-01

To explore nursing care actions that lead to culturally competent care for Hispanic patients. Nurses report apprehension when delivering nursing care because of language barriers and a lack of Hispanic cultural understanding. Research is needed to inform culturally aware nursing practice actions for Hispanic patients. The study used a qualitative, grounded theory design to address the questions: (a) What cultural knowledge should nurses have when caring for Hispanic patients and families and (b) What nursing actions should nurses take to provide culturally competent care? Hispanic lay health promoters and Hispanic community members were interviewed to make recommendations for care. A model was identified that informs culturally competent nursing care. "Connectedness," the central phenomenon, describes nursing actions and contains subthemes explaining influences on nursing care. "Up to You" and "At the Mercy of the System" are descriptive themes influencing connectedness. Connectedness is central to culturally well-informed nurse-patient interactions. © The Author(s) 2014.

Global Health in the Anthropocene: Moving Beyond Resilience and Capitalism

PubMed Central

van de Pas, Remco

2017-01-01

There has been much reflection on the need for a new understanding of global health and the urgency of a paradigm shift to address global health issues. A crucial question is whether this is still possible in current modes of global governance based on capitalist values. Four reflections are provided. (1) Ecological –centered values must become central in any future global health framework. (2) The objectives of ‘sustainability’ and ‘economic growth’ present a profound contradiction. (3) The resilience discourse maintains a gridlock in the functioning of the global health system. (4) The legitimacy of multi-stakeholder governance arrangements in global health requires urgent attention. A dual track approach is suggested. It must be aimed to transform capitalism into something better for global health while in parallel there is an urgent need to imagine a future and pathways to a different world order rooted in the principles of social justice, protecting the commons and a central role for the preservation of ecology. PMID:28812849

Structured Cable for High-Current Coils of Tokamaks

NASA Astrophysics Data System (ADS)

Benson, Christopher; McIntyre, Peter; Sattarov, Akhdiyor; Mann, Thomas

2011-10-01

The 45 kA superconducting cable for the ITER central solenoid coil has yielded questionable results in two recent tests. In both cases the cable Tc increased after cycling only a fraction of the design life, indicating degradation due to fatigue and fracture among the superconducting strands. The Accelerator Research Lab at Texas A&M University is developing a design for a Nb3Sn structured cable suitable for such tokamak coils. The superconductor is configured in 6 sub-cables, and each subcable is supported within a channel of a central support structure within a high-strength armor sheath. The structured cable addresses two issues that are thought to compromise opposition at high current. The strands are supported without cross-overs (which produce stress concentration); and armor sheath and core structure bypass stress through the coil and among subcables so that the stress within each subcable is only what is produced directly upon it. Details of the design and plans for development will be presented.

How the Central American Seaway and an ancient northern passage affected flatfish diversification.

PubMed

Byrne, Lisa; Chapleau, François; Aris-Brosou, Stéphane

2018-05-21

While the natural history of flatfish has been debated for decades, the mode of diversification of this biologically and economically important group has never been elucidated. To address this question, we assembled the largest molecular data set to date, covering > 300 species (out of ca. 800 extant), from 13 of the 14 known families over nine genes, and employed relaxed molecular clocks to uncover their patterns of diversification. As the fossil record of flatfish is contentious, we used sister species distributed on both sides of the American continent to calibrate clock models based on the closure of the Central American Seaway (CAS), and on their current species range. We show that flatfish diversified in two bouts, as species that are today distributed around the Equator diverged during the closure of CAS, while those with a northern range diverged after this, hereby suggesting the existence of a post-CAS closure dispersal for these northern species, most likely along a trans-Arctic northern route, a hypothesis fully compatible with paleogeographic reconstructions.

Understanding the conviction of Binayak Sen: Neocolonialism, political violence and the political economy of health in the central Indian tribal belt.

PubMed

Kennedy, Jonathan J; King, Lawrence P

2011-05-01

The health of adivasis' (Scheduled Tribes or indigenous peoples) is far worse than the general Indian population. Binayak Sen, a renowned Indian public health practitioner, has worked with adivasis in central India for over thirty years. On Christmas Eve 2010 Sen was convicted of involvement with Maoist insurgents and sentenced to life in prison. Sen's conviction has been condemned by Amnesty International and Human Rights Watch, and medical journals such as The Lancet and the British Medical Journal are campaigning for his release. This short report addresses the apparently vexing question of how such a miscarriage of justice could happen to a well-reputed physician in a country that is widely referred to as 'the world's largest democracy'. Both Sen's conviction and the health crisis among adivasis in central India are symptoms of what Paul Farmer (2005) refers to as 'deeper pathologies of power'; specifically, the neocolonial political economy in which the state is very active in dispossessing adivasis but inactive in providing benevolent functions. Thus, the case demonstrates the manner in which public health is intimately related to social, economic and political processes. Copyright © 2011 Elsevier Ltd. All rights reserved.

Questioning Questions: Elementary Teachers' Adaptations of Investigation Questions across the Inquiry Continuum

ERIC Educational Resources Information Center

Biggers, Mandy

2018-01-01

Questioning is a central practice in science classrooms. However, not every question translates into a "good" science investigation. Questions that drive science investigations can be provided by many sources including the teacher, the curriculum, or the student. The variations in the source of investigation questions were explored in…

Geomorphic and vegetation processes of the Willamette River floodplain, Oregon: current understanding and unanswered science questions

USGS Publications Warehouse

Wallick, J. Rose; Jones, Krista L.; O'Connor, Jim E.; Keith, Mackenzie K.; Hulse, David; Gregory, Stanley V.

2013-01-01

4. How is the succession of native floodplain vegetation shaped by present-day flow and sediment conditions? Answering these questions will produce baseline data on the current distributions of landforms and habitats (question 1), the extent of the functional floodplain (question 2), and the effects of modern flow and sediment regimes on future floodplain landforms, habitats, and vegetation succession (questions 3 and 4). Addressing questions 1 and 2 is a logical next step because they underlie questions 3 and 4. Addressing these four questions would better characterize the modern Willamette Basin and help in implementing and setting realistic targets for ongoing management strategies, demonstrating their effectiveness at the site and basin scales, and anticipating future trends and conditions.

"The NASA Solar System Exploration n Research Vistula Institute: Year 1 with New Teams with New and Old Partners!"

NASA Astrophysics Data System (ADS)

Daou, Doris

2015-08-01

Recognizing that science enables exploration, and exploration enables science, NASA created the Solar System Exploration Research Virtual Institute (SSERVI) to address basic and applied scientific questions fundamental to understanding the Moon, Near Earth Asteroids, and the moons of Mars. Primarily using virtual tools to communicate has eliminated the need for a traditional bricks and mortar institute, allowing the hundreds of researchers across the U.S. and the eight international partners to easily communicate and collaborate, from wherever they are. The small, central office located at NASA Ames Research Center in the heart of Silicon Valley, coordinates the institute activities. Newly found synergies across the teams, the sharing of data and facilities, and the ease of communication increase the efficiencies of scientific discovery. More importantly, the birth of ideas formed at the intersection of disparate disciplines can readily be pursued by groups that might not otherwise have formed, or even met! SSERVI follows on the heels of the highly successful NASA Lunar Science Institute (NLSI), a virtual institute dedicated solely to studies of the Moon. The creation of SSERVI has not only expanded our knowledge of the Earth’s nearest neighbor to include other stepping-stones to Mars, but also furthered our ability to address the scientific and technological questions we need to know…before we go!

Agent-based modeling of the spread of the 1918-1919 flu in three Canadian fur trading communities.

PubMed

O'Neil, Caroline A; Sattenspiel, Lisa

2010-01-01

Previous attempts to study the 1918-1919 flu in three small communities in central Manitoba have used both three-community population-based and single-community agent-based models. These studies identified critical factors influencing epidemic spread, but they also left important questions unanswered. The objective of this project was to design a more realistic agent-based model that would overcome limitations of earlier models and provide new insights into these outstanding questions. The new model extends the previous agent-based model to three communities so that results can be compared to those from the population-based model. Sensitivity testing was conducted, and the new model was used to investigate the influence of seasonal settlement and mobility patterns, the geographic heterogeneity of the observed 1918-1919 epidemic in Manitoba, and other questions addressed previously. Results confirm outcomes from the population-based model that suggest that (a) social organization and mobility strongly influence the timing and severity of epidemics and (b) the impact of the epidemic would have been greater if it had arrived in the summer rather than the winter. New insights from the model suggest that the observed heterogeneity among communities in epidemic impact was not unusual and would have been the expected outcome given settlement structure and levels of interaction among communities. Application of an agent-based computer simulation has helped to better explain observed patterns of spread of the 1918-1919 flu epidemic in central Manitoba. Contrasts between agent-based and population-based models illustrate the advantages of agent-based models for the study of small populations. © 2010 Wiley-Liss, Inc.

Employment of a Dual Status Commander in a Multi-State Disaster Operation

DTIC Science & Technology

2016-06-10

propagates parallel commands among affected states without a singular organization to synchronize and prioritize efforts. Thus, the central research ...without a singular organization to synchronize and prioritize efforts. Thus, the central research question is: How can laws be changed to support the...1 The Research Question

Citizen Science for public health.

PubMed

Den Broeder, Lea; Devilee, Jeroen; Van Oers, Hans; Schuit, A Jantine; Wagemakers, Annemarie

2018-06-01

Community engagement in public health policy is easier said than done. One reason is that public health policy is produced in a complex process resulting in policies that may appear not to link up to citizen perspectives. We therefore address the central question as to whether citizen engagement in knowledge production could enable inclusive health policy making. Building on non-health work fields, we describe different types of citizen engagement in scientific research, or 'Citizen Science'. We describe the challenges that Citizen Science poses for public health, and how these could be addressed. Despite these challenges, we expect that Citizen Science or similar approaches such as participatory action research and 'popular epidemiology' may yield better knowledge, empowered communities, and improved community health. We provide a draft framework to enable evaluation of Citizen Science in practice, consisting of a descriptive typology of different kinds of Citizen Science and a causal framework that shows how Citizen Science in public health might benefit both the knowledge produced as well as the 'Citizen Scientists' as active participants.

Consuming untreated water in four southwestern Alaska Native communities: reasons revealed and recommendations for change.

PubMed

Ritter, Troy L; Lopez, Ellen D S; Goldberger, Rachel; Dobson, Jennifer; Hickel, Korie; Smith, Jeffrey; Johnson, Rhonda M; Bersamin, Andrea

2014-12-01

In this article, the authors provide the first in-depth account of why some Alaska Native people drink untreated water when treated water is available. Their qualitative research was conducted in four Alaska Native village communities that have treated water available from a centralized distribution point. Most respondents (n = 172; 82%) reported that some of their household's drinking water came from an untreated source. Motives for drinking untreated water emerged from analysis of open-ended questions about drinking water practice and could be categorized into six themes: chemicals, taste, health, access, tradition, and cost. Importantly, some residents reported consuming untreated water because they both liked untreated water and disliked treated water. As such, interventions to increase safe water consumption should address this dichotomy by providing education about the benefits of treated water alongside the risks involved with drinking untreated water. Based on the findings, the authors provide specific recommendations for developing behavior change interventions that address influences at multiple social-ecological levels.

Tree Nonstructural Carbohydrate Reserves Across Eastern US Temperate Forests

NASA Astrophysics Data System (ADS)

Mantooth, J.; Dietze, M.

2015-12-01

Understanding the roles, importance, and dynamics of tree non-structural carbohydrates (NSCs) is currently an active area of research. The question of how the relationships between NSCs, growth, and mortality can be used to develop more accurate projections of forest dynamics is central to this research. To begin to address this question, we have asked an even more fundamental question: How much are trees allocating carbon to storage, in the form of NSCs, versus new growth? Ecological theory predicts that there should be trade-offs between different plant life history strategies provided that there are the carbon mass-balance constraints to enforce these trade-offs. Current data on tree NSCs lack the spatial and taxonomic extent required to properly address this question. Therefore, we established a network of forest inventory plots at ten sites across the eastern US and measured growth in adult trees using increment cores and repeat measures of diameter at breast height (DBH). Increment cores were also used to measure sapwood NSCs. We hypothesized that across the eastern US, shade tolerant species, e.g. Sugar Maple (Acer saccharum) have the largest NSC reserves and that shade intolerant species have the lowest reserves. We also hypothesized that NSC reserves increase with temperature and precipitation, as with growth, and that within species NSC reserves increase with growth rate. Initial analyses of tree NSCs indicates that trees of intermediate shade tolerance, e.g. Red Oak (Quercus rubra) have the highest concentrations of sapwood NSCs, and among the highest growth rates. Across the entire study region, NSC concentrations are positively correlated with tree size and growth rate. Within species, NSC concentrations are also positively correlated with growth rate. Across functional groups healthy individuals have significantly higher sapwood NSC concentrations than visibly stressed individuals. There are also significantly lower NSC concentrations in sapwood of dead trees.

ECG Voltage in Relation to Peripheral and Central Ambulatory Blood Pressure.

PubMed

Yang, Wen-Yi; Mujaj, Blerim; Efremov, Ljupcho; Zhang, Zhen-Yu; Thijs, Lutgarde; Wei, Fang-Fei; Huang, Qi-Fang; Luttun, Aernout; Verhamme, Peter; Nawrot, Tim S; Boggia, José; Staessen, Jan A

2018-01-12

The heart ejects in the central elastic arteries. No previous study in workers described the diurnal profile of central blood pressure (BP) or addressed the question whether electrocardiogram (ECG) indexes are more closely associated with central than peripheral BP. In 177 men (mean age, 29.1 years), we compared the associations of ECG indexes with brachial and central ambulatory BP, measured over 24 hours by the validated oscillometric Mobil-O-Graph 24h PWA monitor. From wakefulness to sleep, as documented by diaries, systolic/diastolic BP decreased by 11.7/13.1 mm Hg peripherally and 9.3/13.6 mm Hg centrally, whereas central pulse pressure (PP) increased by 4.3 mm Hg (P < 0.0001). Over 24 hours and the awake and asleep periods, the peripheral-minus-central differences in systolic/diastolic BPs averaged 11.8/-1.6, 12.7/-1.8, and 10.3/-1.2 mm Hg, respectively (P < 0.0001). Cornell voltage and index averaged 1.18 mV and 114.8 mV·ms. Per 1-SD increment in systolic/diastolic BP, the Cornell voltages were 0.104/0.086 mV and 0.082/0.105 mV higher in relation to brachial 24-hour and asleep BP and 0.088/0.90 mV and 0.087/0.107 mV higher in relation to central BP. The corresponding estimates for the Cornell indexes were 9.6/8.6 and 8.2/10.5 mV·ms peripherally and 8.6/8.9 and 8.8/10.7 mV·ms centrally. The regression slopes (P ≥ 0.067) and correlation coefficients (P ≥ 0.088) were similar for brachial and central BP. Associations of ECG measurements with awake BP and PP were not significant. Peripheral and central BPs run in parallel throughout the day and are similarly associated with the Cornell voltage and index. © The Author 2017. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.

ECG Voltage in Relation to Peripheral and Central Ambulatory Blood Pressure

PubMed Central

Yang, Wen-Yi; Mujaj, Blerim; Efremov, Ljupcho; Zhang, Zhen-Yu; Thijs, Lutgarde; Wei, Fang-Fei; Huang, Qi-Fang; Luttun, Aernout; Verhamme, Peter; Nawrot, Tim S; Boggia, José; Staessen, Jan A

2018-01-01

Abstract BACKGROUND The heart ejects in the central elastic arteries. No previous study in workers described the diurnal profile of central blood pressure (BP) or addressed the question whether electrocardiogram (ECG) indexes are more closely associated with central than peripheral BP. METHODS In 177 men (mean age, 29.1 years), we compared the associations of ECG indexes with brachial and central ambulatory BP, measured over 24 hours by the validated oscillometric Mobil-O-Graph 24h PWA monitor. RESULTS From wakefulness to sleep, as documented by diaries, systolic/diastolic BP decreased by 11.7/13.1 mm Hg peripherally and 9.3/13.6 mm Hg centrally, whereas central pulse pressure (PP) increased by 4.3 mm Hg (P < 0.0001). Over 24 hours and the awake and asleep periods, the peripheral-minus-central differences in systolic/diastolic BPs averaged 11.8/–1.6, 12.7/–1.8, and 10.3/–1.2 mm Hg, respectively (P < 0.0001). Cornell voltage and index averaged 1.18 mV and 114.8 mV·ms. Per 1-SD increment in systolic/diastolic BP, the Cornell voltages were 0.104/0.086 mV and 0.082/0.105 mV higher in relation to brachial 24-hour and asleep BP and 0.088/0.90 mV and 0.087/0.107 mV higher in relation to central BP. The corresponding estimates for the Cornell indexes were 9.6/8.6 and 8.2/10.5 mV·ms peripherally and 8.6/8.9 and 8.8/10.7 mV·ms centrally. The regression slopes (P ≥ 0.067) and correlation coefficients (P ≥ 0.088) were similar for brachial and central BP. Associations of ECG measurements with awake BP and PP were not significant. CONCLUSIONS Peripheral and central BPs run in parallel throughout the day and are similarly associated with the Cornell voltage and index. PMID:28985271

Neural cascade of conflict processing: Not just time-on-task.

PubMed

McKay, Cameron C; van den Berg, Berry; Woldorff, Marty G

2017-02-01

In visual conflict tasks (e.g., Stroop or flanker), response times (RTs) are generally longer on incongruent trials relative to congruent ones. Two event-related-potential (ERP) components classically associated with the processing of stimulus conflict are the fronto-central, incongruency-related negativity (N inc ) and the posterior late-positive complex (LPC), which are derived from the ERP difference waves for incongruent minus congruent trials. It has been questioned, however, whether these effects, or other neural measures of incongruency (e.g., fMRI responses in the anterior cingulate), reflect true conflict processing, or whether such effects derive mainly from differential time-on-task. To address this question, we leveraged high-temporal-resolution ERP measures of brain activity during two behavioral tasks. The first task, a modified Erikson flanker paradigm (with congruent and incongruent trials), was used to evoke the classic RT and ERP effects associated with conflict. The second was a non-conflict control task in which, participants visually discriminated a single stimulus (with easy and hard discrimination conditions). Behaviorally, the parameters were titrated to yield similar RT effects of conflict and difficulty (27ms). Neurally, both within-task contrasts showed an initial fronto-central negative-polarity wave (N2-latency effect), but they then diverged. In the difficulty difference wave, the initial negativity led directly into the posterior LPC, whereas in the incongruency contrast the initial negativity was followed a by a second fronto-central negative peak (N inc ), which was then followed by a considerably longer-latency LPC. These results provide clear evidence that the longer processing for incongruent stimulus inputs do not just reflect time-on-task or difficulty, but include a true conflict-processing component. Copyright © 2017 Elsevier Ltd. All rights reserved.

Neural cascade of conflict processing: not just time-on-task

PubMed Central

McKay, Cameron C.; van den Berg, Berry; Woldorff, Marty G.

2017-01-01

In visual conflict tasks (e.g., Stroop or flanker), response times (RTs) are generally longer on incongruent trials relative to congruent ones. Two event-related-potential (ERP) components classically associated with the processing of stimulus conflict are the fronto-central, incongruency-related negativity (Ninc) and the posterior late-positive complex (LPC), which are derived from the ERP difference waves for incongruent minus congruent trials. It has been questioned, however, whether these effects, or other neural measures of incongruency (e.g., fMRI responses in the anterior cingulate), reflect true conflict processing, or whether such effects derive mainly from differential time-on-task. To address this question, we leveraged high-temporal-resolution ERP measures of brain activity during two behavioral tasks. The first task, a modified Erikson flanker paradigm (with congruent and incongruent trials), was used to evoke the classic RT and ERP effects associated with conflict. In the second, a non-conflict comparison condition, participants visually discriminated a single stimulus (with easy and hard discrimination conditions). Behaviorally, the parameters were titrated to yield similar RT effects of conflict and difficulty (27 ms). Neurally, both within-task contrasts showed an initial fronto-central negative-polarity wave (N2-latency effect), but they then diverged. In the difficulty difference wave, the initial negativity led directly into the posterior LPC, whereas in the incongruency contrast the initial negativity was followed a by a second fronto-central negative peak (Ninc), which was then followed by a considerably longer-latency LPC. These results provide clear evidence that the longer processing for incongruent stimulus inputs do not just reflect time-on-task or difficulty, but include a true conflict-processing component. PMID:28017818

The Ancient Maya Landscape: Facing the Challenges and Embracing the Promise of Integrating Archaeology, Remote Sensing, Soil Science and Hydrologic Modeling for Coupled Natural and Human Systems.

NASA Astrophysics Data System (ADS)

Murtha, T., Jr.; Duffy, C.; Cook, B. D.; Schroder, W.; Webster, D.; French, K. D.; Alcover, O.; Golden, C.; Balzotti, C.; Shaffer, D.

2016-12-01

Relying on a niche inheritance perspective, this paper discusses the long-term spatial and temporal dynamics of land-use management, agricultural decision making and patterns of resource availability in the tropical lowlands of Central America. We introduce and describe ongoing research that addresses a series of long standing questions about coupled natural and human history dynamics in the Central Maya lowlands, emphasizing the role of landscape and region to address these questions. First, we summarize the results of a CNH pilot study focused on the evolution of the regional landscape of Tikal, Guatemala. Particular attention is centered on how we integrated landscape survey, traditional archaeology and soil studies to understand the spatial and temporal dynamics of agricultural land use and intensification over a two thousand period. Additionally, we discuss how these results were integrated into remote sensing, hydrological and erosion models to better understand how past changes in available water and productive land compare to what we know about settlement patterns in the Tikal Region over that same time period. We not only describe how the Maya transformed this landscape, but also how the region influenced changing patterns of settlement and land use. We finish this section with a discussion of some of the unique challenges integrating archaeological information to study CNH dynamics during this pilot study. Second, we introduce a new project designed to `scale up' the pilot study for a macro-regional analysis of the lowland Maya landscape. The new project leverages a uniquely sampled LIDAR data set designed to refine measurements of above ground carbon storage. Our new project quantitatively examines these data for evidence for past human activity. Preliminary results offer a promising path for tightly integrating archaeology, natural science, remote sensing and modeling for studying CNH dynamics in the deep and recent past.

Still Subversive after All These Years: The Relevance of Feminist Therapy in the Age of Evidence-Based Practice

ERIC Educational Resources Information Center

Brown, Laura S.

2006-01-01

In this article, based on my Carolyn Wood Sherif Memorial Award Address, I address questions of the viability of feminist practice in the current zeitgeist. Using the framework of responding to questions raised by doctoral students about feminist therapy, I address how feminist practice aligns with the evidence-based practice movement,…

Starburst in the Interacting HII Galaxy II Zw 40 and in Non-Interacting HII Galaxies

NASA Astrophysics Data System (ADS)

Telles, E.

2010-06-01

In this poster, I summarize the results of our integral field spectroscopic observations of the nearby prototype of HII galaxies, II Zw 40. Observations with GMOS-IFU on GEMINI-North in the optical allowed us to make a detailed kinematic picture of the central starburst, while SINFONI with adaptive optics on the ESO-VLT gave us a near-IR view of the interplay between the ISM phases. Here, I also address the question that not all starbursts require an external trigger such as a galaxy-galaxy encounter, as it seems to be the case for a fraction of low luminosity HII galaxies. We speculate that these may form stars spontaneously like "popcorn in a pan".

Assessing potential future environmental legal events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tonn, B.; Petrich, C.

1997-10-28

This report addresses the topic of environmental citizenship in the United States. The term refers to responsibilities each of us have with respect to helping our communities and nation make sound environmental decisions. This research centers on the citizens and what we ought to be doing, as opposed to what the government ought to be doing for us, to improve environmental citizenship. This report examines four central questions: What are the requirements (i.e., responsibilities) of citizenship vis-a-vis environmental decision- making processes; what constraints limit people`s ability to meet these requirements; what does our form of governance do to help ormore » hinder in meeting these requirements; and what recommendations can be put forth to improve public participation in environmental decision making?« less

Core questions in domestication research

PubMed Central

Zeder, Melinda A.

2015-01-01

The domestication of plants and animals is a key transition in human history, and its profound and continuing impacts are the focus of a broad range of transdisciplinary research spanning the physical, biological, and social sciences. Three central aspects of domestication that cut across and unify this diverse array of research perspectives are addressed here. Domestication is defined as a distinctive coevolutionary, mutualistic relationship between domesticator and domesticate and distinguished from related but ultimately different processes of resource management and agriculture. The relative utility of genetic, phenotypic, plastic, and contextual markers of evolving domesticatory relationships is discussed. Causal factors are considered, and two leading explanatory frameworks for initial domestication of plants and animals, one grounded in optimal foraging theory and the other in niche-construction theory, are compared. PMID:25713127

Characteristics of the near-bottom suspended sediment field over the continental shelf off northern California based on optical attenuation measurements during STRESS and SMILE

NASA Astrophysics Data System (ADS)

Trowbridge, J. H.; Butman, B.; Limeburner, R.

1994-08-01

Time-series measurements of current velocity, optical attenuation and surface wave intensity obtained during the Sediment Transport Events on Shelves and Slopes (STRESS) experiments, combined with shipboard measurements of conductivity, temperature and optical attenuation obtained during the Shelf Mixed Layer Experiment (SMILE), provide a description of the sediment concentration field over the central and outer shelf off northern California. The questions addressed are: (1) existence and characteristics of bottom nepheloid layers and their relationship to bottom mixed layers; (2) characteristics of temporal fluctuations in sediment concentration and their relationship to waves and currents; (3) spatial scales over which suspended sediment concentrations vary horizontally; and (4) vertical distribution of suspended sediment.

Child Development in Developing Countries: Introduction and Methods

PubMed Central

Bornstein, Marc H.; Britto, Pia Rebello; Nonoyama-Tarumi, Yuko; Ota, Yumiko; Petrovic, Oliver; Putnick, Diane L.

2011-01-01

The Multiple Indicator Cluster Survey (MICS) is a nationally representative, internationally comparable household survey implemented to examine protective and risk factors of child development in developing countries around the world. This Introduction describes the conceptual framework, nature of the MICS3, and general analytic plan of articles in this Special Section. The articles that follow describe the situations of children with successive foci on nutrition, parenting, discipline and violence, and the home environment addressing two common questions: How do developing and underresearched countries in the world vary with respect to these central indicators of children's development? and How do key indicators of national development relate to child development in each of these substantive areas? The Special Section concludes with policy implications from the international findings. PMID:22277004

Roadmapping Future E-Government Research

NASA Astrophysics Data System (ADS)

Bicking, Melanie

Global electronic markets, virtual organisations, virtual identities, virtual products and services, and Internet-related crime are growing in prominence and importance. In a world that is increasingly non-physical and borderless, what are government's roles, responsibilities and limitations? The Internet plays a central role within the transformation process from traditional governments towards modern and innovative government that the requirements of an Information Society. Based on the findings of the eGovRTD2020 project, that aims at identifying key research challenges and at implementing a model for a holistic government with horizon 2020, this paper explains the necessity to investigate and understand the Internet and in particular government's role and responsibilities in it. Furthermore, the paper provides a research roadmap that details how to address certain issue related research questions.

Technology, Biopolitics, Rationalities and Choices: Recent Studies of Reproduction.

PubMed

Whittaker, Andrea

2015-01-01

New synergies across anthropology, science and technology studies (STS), legal studies and sociology, bring fresh theoretical perspectives to the study of reproduction. Recent works on reproduction trace some of the changing rationalities: from the tactics of feminist self-help health movements in 1970s and 1980s in the US, to the commercialized experience of pregnancy and the various configurations, policies and legalities addressing globalized genetic and assisted reproductive technologies. Reproductive decision-making is deeply entangled with neoliberalism, welfare reforms, racial and geographic disparities, economic stratification and cultural rationalities to produce inequalities. Studies of reproduction remain central to basic anthropological questions: what it means to be human, what constitutes life, how we live our lives, and how societies value particular lives.

Thought beyond language: neural dissociation of algebra and natural language.

PubMed

Monti, Martin M; Parsons, Lawrence M; Osherson, Daniel N

2012-08-01

A central question in cognitive science is whether natural language provides combinatorial operations that are essential to diverse domains of thought. In the study reported here, we addressed this issue by examining the role of linguistic mechanisms in forging the hierarchical structures of algebra. In a 3-T functional MRI experiment, we showed that processing of the syntax-like operations of algebra does not rely on the neural mechanisms of natural language. Our findings indicate that processing the syntax of language elicits the known substrate of linguistic competence, whereas algebraic operations recruit bilateral parietal brain regions previously implicated in the representation of magnitude. This double dissociation argues against the view that language provides the structure of thought across all cognitive domains.

Toward a Comprehensive Strategy to Mitigate Dissemination of Environmental Sources of Antibiotic Resistance.

PubMed

Vikesland, Peter J; Pruden, Amy; Alvarez, Pedro J J; Aga, Diana; Bürgmann, Helmut; Li, Xiang-Dong; Manaia, Celia M; Nambi, Indumathi; Wigginton, Krista; Zhang, Tong; Zhu, Yong-Guan

2017-11-21

Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.

The Central Nervous Connections Involved in the Vomiting Reflex

NASA Technical Reports Server (NTRS)

Brizzee, K. R.; Mehler, W. R.

1986-01-01

The vomiting reflex may be elicited by a number of different types or classes of stimuli involving many varieties of receptor structures and considerable diversity in afferent pathways and central connections. Central relay or mediating structures thus may vary widely according to the type of initial emetic stimulus. The emetic circuits which have been most completely delineated to date are probably those in which the Chemoreceptor Trigger Zone (CTZ) in the Area Postrema (AP) functions as a key mediating structure. Even in this system, however, there are large gaps in our knowledge of the nerve tracts and central nervous connections involved. Knowledge of most other emetic circuits subserving the emetic reflex resulting from many diverse types of stimuli such, for example, as emotional stress (e.g. psychogenic vomiting, Wruble et al. 1982), pain (e.g. testicular trauma), and chemical or mechanical irritation of the gastrointestinal tract or urinary tract is quite incomplete at this time, thus precluding any very adequate description of their central connections at present. One physiological system, however, which has received considerable attention recently in relation to the vomiting reflex elicited by motion stimuli is the vestibular system. Due to the paucity of data on central nervous connections of several or the non-vestibular types of emetic stimuli cited above, we will devote most of our attention in this brief review to the central connections of the vestibular system which seem likely to be involved in the vomiting response to motion stimuli. However, the latter part of the review will be concerned with the concept of the reticular vomiting centre in relation to the ParviCellular Reticular Formation (PCRF), and will thus probably pertain to all of the many classes of emetic stimuli since it will address the question of the final common emetic pathway.

Assessing the need for a new nationally representative household panel survey in the United States

PubMed Central

Moffitt, Robert; Schoeni, Robert F.; Brown, Charles; Chase-Lansdale, P. Lindsay; Couper, Mick P.; Diez-Roux, Ana V.; Hurst, Erik; Seltzer, Judith A.

2015-01-01

We introduce this special issue on the critical matter of whether the existing household panel surveys in the U.S. are adequate to address the important emerging social science and policy questions of the next few decades. We summarize the conference papers which address this issue in different domains. The papers detail many new and important emerging research questions but also identify key limitations in existing panels in addressing those questions. To address these limitations, we consider the advantages and disadvantages of initiating a new, general-purpose omnibus household panel in the U.S. We also discuss the particular benefits of starting new panels that have specific targeted domains such as child development, population health and health care. We also develop a list of valuable enhancements to existing panels which could address many of their limitations. PMID:26688609

The relevance of α-KLOTHO to the central nervous system: Some key questions.

PubMed

Cararo-Lopes, Marina Minto; Mazucanti, Caio Henrique Yokoyama; Scavone, Cristoforo; Kawamoto, Elisa Mitiko; Berwick, Daniel Charles

2017-07-01

α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α-Klotho is also expressed in the choroid plexus, where it is released into the cerebrospinal fluid. Nonetheless, α-Klotho is also expressed in the brain parenchyma. Accumulating evidence indicates that this pool of α-Klotho, which we define as brain α-Klotho, may play important roles as a neuroprotective factor and in promoting myelination, thereby supporting healthy brain aging. Here we summarize what is known about brain α-Klotho before focusing on the outstanding scientific questions related to its function. We believe there is a need for in vitro studies designed to distinguish between brain α-Klotho and other pools of α-Klotho, and for a greater understanding of the basic function of soluble α-Klotho. The mechanism by which the human KL-VS variant affects cognition also requires further elucidation. To help address these questions we suggest some experimental approaches that other laboratories might consider. In short, we hope to stimulate fresh ideas and encourage new research approaches that will allow the importance of α-Klotho for the aging brain to become clear. Copyright © 2017. Published by Elsevier B.V.

Developing a Security Profile.

ERIC Educational Resources Information Center

Woodcock, Chris

1999-01-01

Examines the questions schools should address when re-evaluating how to protect people, property, and assets. Questions addressed include where and how to begin to improve security in a school, getting the most protection economically, establishing where electronic security should be used, using surveillance cameras and systems, and what the role…

Addressing Phonological Questions with Ultrasound

ERIC Educational Resources Information Center

Davidson, Lisa

2005-01-01

Ultrasound can be used to address unresolved questions in phonological theory. To date, some studies have shown that results from ultrasound imaging can shed light on how differences in phonological elements are implemented. Phenomena that have been investigated include transitional schwa, vowel coalescence, and transparent vowels. A study of…

[Shortage and need of physicians in Germany? Questions addressed to health services research].

PubMed

Adler, G; v d Knesebeck, J-H

2011-02-01

The problem of shortage of physicians has been discussed controversially in Germany for years, and the different positions of the interest groups involved have not been resolved. The question of the present and anticipated future requirement of physicians is central for an appropriate and necessary medical care of the population. In the analysis, supply and demand of medical care have to be distinguished. Relatively reliable data do exist for the supply of physicians; however, the changing number of working hours that male and--in particular female--physicians are willing to contribute should be taken into consideration. Reliable data for the future demand are presently not available. Several variables (e.g., demography, disease spectrum of an aging society, medical progress, the changing rules of working hours, and the shift of medical care between hospital and practice care) depend on future developments. Considering the existing serious indicators of a growing shortage of physicians, it is recommended to put more effort into the scientific investigation of these factors. More profound data should improve the basis for decisions in health and education politics.

The evolution of phenotypic integration: How directional selection reshapes covariation in mice

PubMed Central

Penna, Anna; Melo, Diogo; Bernardi, Sandra; Oyarzabal, Maria Inés; Marroig, Gabriel

2017-01-01

Abstract Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex phenotypes, covariation plays an even more important role, as genetic associations between traits can bias and alter evolutionary change. Covariation can be shaped by complex interactions between loci, and this genetic architecture can also change during evolution. In this article, we analyzed mouse lines experimentally selected for changes in size to address the question of how multivariate covariation changes under directional selection, as well as to identify the consequences of these changes to evolution. Selected lines showed a clear restructuring of covariation in their cranium and, instead of depleting their size variation, these lines increased their magnitude of integration and the proportion of variation associated with the direction of selection. This result is compatible with recent theoretical works on the evolution of covariation that take the complexities of genetic architecture into account. This result also contradicts the traditional view of the effects of selection on available covariation and suggests a much more complex view of how populations respond to selection. PMID:28685813

Visual short-term memory for oriented, colored objects.

PubMed

Shin, Hongsup; Ma, Wei Ji

2017-08-01

A central question in the study of visual short-term memory (VSTM) has been whether its basic units are objects or features. Most studies addressing this question have used change detection tasks in which the feature value before the change is highly discriminable from the feature value after the change. This approach assumes that memory noise is negligible, which recent work has shown not to be the case. Here, we investigate VSTM for orientation and color within a noisy-memory framework, using change localization with a variable magnitude of change. A specific consequence of the noise is that it is necessary to model the inference (decision) stage. We find that (a) orientation and color have independent pools of memory resource (consistent with classic results); (b) an irrelevant feature dimension is either encoded but ignored during decision-making, or encoded with low precision and taken into account during decision-making; and (c) total resource available in a given feature dimension is lower in the presence of task-relevant stimuli that are neutral in that feature dimension. We propose a framework in which feature resource comes both in packaged and in targeted form.

Testing the importance of family solidarity, community structure, information access, and social capital in predicting nutrition health knowledge and food choices in the Philippines.

PubMed

Moxley, Robert L; Jicha, Karl A; Thompson, Gretchen H

2011-01-01

This study investigates the influence of family solidarity, community structure, information access, social capital, and socioeconomic status on the extent of nutrition and health knowledge (NHK) among primary household meal planners. In turn, we pose the question: does this knowledge influence dietary decision making? Data are taken from a survey determining socioeconomic impacts of vitamin A fortified peanut butter on Philippine households. Questions on the relationships of nutrition to health were selected to construct a knowledge index on which household respondents could be ranked. We then tested hypotheses regarding what types of individual, family-level, and community structural characteristics would predict performance on this index. The results indicate that the strongest predictors of NHK come from sociological theory related to family solidarity and community centrality, in addition to information accessibility and household income. Our findings also indicate that NHK influences dietary choices with regard to the purchase of a vitamin fortified staple food product, which is essential when addressing nutritional deficiency problems in developing countries.

Chicks with dicks, men in dresses: what it means to be a drag queen.

PubMed

Taylor, Verta; Rupp, Leila J

2004-01-01

One of the burning questions about drag queens among both scholars and audiences is whether they are more gender-revolutionaries than gender-conservatives. Do they primarily destabilize gender and sexual categories by making visible the social basis of femininity and masculinity, heterosexuality and homosexuality? Or are they more apt to reinforce the dominant binary and hierarchical gender and sexual systems by appropriating gender displays and expressing sexual desires associated with traditional femininity and institutionalized heterosexuality? We address this question through a case study of drag queens at the 801 Cabaret in Key West, Florida. On the basis of life histories, observations of their performances, and focus groups with audience members, we examine the role of gender and sexuality in the process of becoming a drag queen and in the personal identities of drag queens. We find that transgenderism, same-sex sexuality, and theatrical performance are central to the personal identities of these drag queens, who use drag to forge personal and collective identities that are neither masculine nor feminine, but rather their own complex genders.

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.

PubMed

Schöndorf, David C; Ivanyuk, Dina; Baden, Pascale; Sanchez-Martinez, Alvaro; De Cicco, Silvia; Yu, Cong; Giunta, Ivana; Schwarz, Lukas K; Di Napoli, Gabriele; Panagiotakopoulou, Vasiliki; Nestel, Sigrun; Keatinge, Marcus; Pruszak, Jan; Bandmann, Oliver; Heimrich, Bernd; Gasser, Thomas; Whitworth, Alexander J; Deleidi, Michela

2018-06-05

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate age-related metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD. Our findings suggest NR as a viable clinical avenue for neuroprotection in PD and other neurodegenerative diseases. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Cytokinin signalling inhibitory fields provide robustness to phyllotaxis

NASA Astrophysics Data System (ADS)

Besnard, Fabrice; Refahi, Yassin; Morin, Valérie; Marteaux, Benjamin; Brunoud, Géraldine; Chambrier, Pierre; Rozier, Frédérique; Mirabet, Vincent; Legrand, Jonathan; Lainé, Stéphanie; Thévenon, Emmanuel; Farcot, Etienne; Cellier, Coralie; Das, Pradeep; Bishopp, Anthony; Dumas, Renaud; Parcy, François; Helariutta, Ykä; Boudaoud, Arezki; Godin, Christophe; Traas, Jan; Guédon, Yann; Vernoux, Teva

2014-01-01

How biological systems generate reproducible patterns with high precision is a central question in science. The shoot apical meristem (SAM), a specialized tissue producing plant aerial organs, is a developmental system of choice to address this question. Organs are periodically initiated at the SAM at specific spatial positions and this spatiotemporal pattern defines phyllotaxis. Accumulation of the plant hormone auxin triggers organ initiation, whereas auxin depletion around organs generates inhibitory fields that are thought to be sufficient to maintain these patterns and their dynamics. Here we show that another type of hormone-based inhibitory fields, generated directly downstream of auxin by intercellular movement of the cytokinin signalling inhibitor ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6 (AHP6), is involved in regulating phyllotactic patterns. We demonstrate that AHP6-based fields establish patterns of cytokinin signalling in the meristem that contribute to the robustness of phyllotaxis by imposing a temporal sequence on organ initiation. Our findings indicate that not one but two distinct hormone-based fields may be required for achieving temporal precision during formation of reiterative structures at the SAM, thus indicating an original mechanism for providing robustness to a dynamic developmental system.

Addressing Parental Vaccination Questions in the School Setting

ERIC Educational Resources Information Center

Luthy, Karlen E.; Burningham, Jana; Eden, Lacey M.; Macintosh, Janelle L. B.; Beckstrand, Renea L.

2016-01-01

School nurses work in a unique environment with key opportunities to address parental concerns and questions regarding their child's health. A common concern for parents during school enrollment is childhood vaccination safety and efficacy. As public health leaders, school nurses are well respected among parents, therefore school nurses are in a…

The Internet, Political Participation, and E-Government in Comparative Perspective

ERIC Educational Resources Information Center

Sharma, Mukul

2010-01-01

This dissertation addresses three important questions, together with optimistic and pessimistic views, about people's access/use of the Internet, its ability to promote their participation in politics, and its role in government provision of information and public services. Chapter Two addresses the question of the determinants of people's access…

From the Field: Learning Leaders

ERIC Educational Resources Information Center

Weigel, Kathleen; Jones, Richard

2015-01-01

Leadership is essential to successful schools. One of the ways to support effective school leadership is to share ideas and best practices to address the common challenges faced by school leaders. This question and response format addresses common challenges and questions from practicing school leaders in the manner that a mentor might respond to…

Secondary Data Analysis: An Important Tool for Addressing Developmental Questions

ERIC Educational Resources Information Center

Greenhoot, Andrea Follmer; Dowsett, Chantelle J.

2012-01-01

Existing data sets can be an efficient, powerful, and readily available resource for addressing questions about developmental science. Many of the available databases contain hundreds of variables of interest to developmental psychologists, track participants longitudinally, and have representative samples. In this article, the authors discuss the…

Many Faces of Mexico.

ERIC Educational Resources Information Center

Ruiz, Octavio Madigan; And Others

This resource book braids together the cultural, political and economic realities which together shape Mexican history. The guiding question for the book is that of: "What do we need to know about Mexico's past in order to understand its present and future?" To address the question, the interdisciplinary resource book addresses key…

Reframing "The Italian": Questions of Audience Address in Early Cinema.

ERIC Educational Resources Information Center

Keil, Charlie

1990-01-01

Analyzes "The Italian" (1915), an early "immigrant" film, examining its problematic relation to questions of working-class and middle-class audience composition. Shows how this film reveals that the creation of narratives suitable for diverse audiences requires continuous readjustment of an adequate mode of address. (MM)

Array tomography of physiologically-characterized CNS synapses.

PubMed

Valenzuela, Ricardo A; Micheva, Kristina D; Kiraly, Marianna; Li, Dong; Madison, Daniel V

2016-08-01

The ability to correlate plastic changes in synaptic physiology with changes in synaptic anatomy has been very limited in the central nervous system because of shortcomings in existing methods for recording the activity of specific CNS synapses and then identifying and studying the same individual synapses on an anatomical level. We introduce here a novel approach that combines two existing methods: paired neuron electrophysiological recording and array tomography, allowing for the detailed molecular and anatomical study of synapses with known physiological properties. The complete mapping of a neuronal pair allows determining the exact number of synapses in the pair and their location. We have found that the majority of close appositions between the presynaptic axon and the postsynaptic dendrite in the pair contain synaptic specializations. The average release probability of the synapses between the two neurons in the pair is low, below 0.2, consistent with previous studies of these connections. Other questions, such as receptor distribution within synapses, can be addressed more efficiently by identifying only a subset of synapses using targeted partial reconstructions. In addition, time sensitive events can be captured with fast chemical fixation. Compared to existing methods, the present approach is the only one that can provide detailed molecular and anatomical information of electrophysiologically-characterized individual synapses. This method will allow for addressing specific questions about the properties of identified CNS synapses, even when they are buried within a cloud of millions of other brain circuit elements. Copyright © 2016. Published by Elsevier B.V.

[The Bremen periodic health exam - feasibility of a new concept].

PubMed

Schmiemann, Guido; Biesewig-Siebenmorgen, Jürgen; Gebhardt, Klaus; Egidi, Günther

2014-01-01

All members of the Statutory Health Insurance are entitled to receive preventive health examinations. The current concept, however, does not take individual risk factors into account systematically. To improve this, the "Bremen Health Examination" was developed. The central component is a screening questionnaire to be completed by the patient, which is stratified by age, i.e., 35 to 69 years and ≥ 70 years. The feasibility and acceptance of this concept have been assessed. In a prospective observational study, a selected sample of general practitioners (GPs) was asked to implement the questionnaires during all preventive health examinations within a four-week period. The GPs subsequently answered content-related questions as well as Likert-scaled questions on the relevance of the issues addressed, and the feasibility of the new concept. 17 out of 20 GPs approached for the study included a total of 171 patients. On average, the patients in the two groups were 52 and 75 years of age, respectively, and answered 4.4 prompting questions positively. Age and gender had no significant effect on the frequency of "positively" answered questions. Implementing the questionnaire extended the duration of the health examination, however, GPs overall rated the time required for discussing newly assessed problems as adequate (four-level Likert scale, 1=yes; 4=no; Ø 1.59; SD 0.77). The implementation of the Bremen Health Examination appears to be feasible from the GP perspective. Copyright © 2014. Published by Elsevier GmbH.

Favouring more rigour when investigating human eating behaviour is like supporting motherhood and apple pie: A response to Robinson, Bevelander, Field, and Jones (2018).

PubMed

Hetherington, Marion M; Rolls, Barbara J

2018-05-11

In a 1987 paper, addressing questions about factors that influence the initiation, maintenance, and termination of food intake, we wrote, "development of systematic procedures to measure eating behaviour is essential if descriptive and inferential statistics are to be applied to answering such questions, giving them power and replicability" (Hetherington & Rolls, 1987 page 77). Therefore, as longstanding advocates of rigorous procedures in laboratory-based investigations of food intake, we welcome Robinson et al.'s (2018) clear recommendations for laboratory studies. However, this is akin to voting for "motherhood and apple pie", and few would argue against deployment of improved procedures for these studies. What then can we contribute to the debate in order to refine the recommendations made or add to them? Our most important message for researchers is that the central hypothesis or main research question will determine the most appropriate methods for any study. If a laboratory-based study is planned, then there are basic methodological questions that must be answered before proceeding to a final protocol. While such guidelines are needed to ensure basic methodological rigour, these should not be so prescriptive as to inhibit creativity. Here we provide several thoughts on how to advance studies of ingestive behaviour, including the need to apply appropriate controls, encouragement to move beyond convenience samples, and to remember the value of exploratory, observational, and naturalistic studies to complement laboratory-based studies. Copyright © 2018. Published by Elsevier Ltd.

Why is neuroimmunopharmacology crucial for the future of addiction research?

PubMed

Hutchinson, Mark R; Watkins, Linda R

2014-01-01

A major development in drug addiction research in recent years has been the discovery that immune signaling within the central nervous system contributes significantly to mesolimbic dopamine reward signaling induced by drugs of abuse, and hence is involved in the presentation of reward behaviors. Additionally, in the case of opioids, these hypotheses have advanced through to the discovery of the novel site of opioid action at the innate immune pattern recognition receptor Toll-like receptor 4 as the necessary triggering event that engages this reward facilitating central immune signaling. Thus, the hypothesis of major proinflammatory contributions to drug abuse was born. This review will examine these key discoveries, but also address several key lingering questions of how central immune signaling is able to contribute in this fashion to the pharmacodynamics of drugs of abuse. It is hoped that by combining the collective wisdom of neuroscience, immunology and pharmacology, into Neuroimmunopharmacology, we may more fully understanding the neuronal and immune complexities of how drugs of abuse, such as opioids, create their rewarding and addiction states. Such discoveries will point us in the direction such that one day soon we might successfully intervene to successfully treat drug addiction. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'. Copyright © 2013 Elsevier Ltd. All rights reserved.

Sigma receptors: biology and therapeutic potential.

PubMed

Guitart, Xavier; Codony, Xavier; Monroy, Xavier

2004-07-01

More than 20 years after the identification of the sigma receptors as a unique binding site in the brain and in the peripheral organs, several questions regarding this receptor are still open. Only one of the subtypes of the receptor has been cloned to date, but the endogenous ligand still remains unknown, and the possible association of the receptor with a conventional second messenger system is controversial. From the very beginning, the sigma receptors were associated with various central nervous system disorders such as schizophrenia or movement disorders. Today, after hundreds of papers dealing with the importance of sigma receptors in brain function, it is widely accepted that sigma receptors represent a new and different avenue in the possible pharmacological treatment of several brain-related disorders. In this review, what is known about the biology of the sigma receptor regarding its putative structure and its distribution in the central nervous system is summarized first. The role of sigma receptors regulating cellular functions and other neurotransmitter systems is also addressed, as well as a short overview of the possible endogenous ligands. Finally, although no specific sigma ligand has reached the market, different pharmacological approaches to the alleviation and treatment of several central nervous system disorders and deficits, including schizophrenia, pain, memory deficits, etc., are discussed, with an overview of different compounds and their potential therapeutic use.

Recognizing the centrality of gender identity and stereotype knowledge in gender development and moving toward theoretical integration: reply to Bandura and Bussey (2004).

PubMed

Martin, Carol Lynn; Ruble, Diane N; Szkrybalo, Joel

2004-09-01

Most of the critique in the A. Bandura and K. Bussey (see record 2004-18097-001) commentary is a misunderstanding or misrepresentation of the points made by C. L. Martin, D. N. Ruble, and J. Szkrybalo in their 2002 Psychological Bulletin article (see record 2002-18663-003). First, Martin et al. never intended to present a comprehensive theory; instead, it was a review of 2 different cognitive approaches to gender development. Second, there is no time line test that has been failed; instead, gender cognitions may occur earlier than initially believed. Third, Bandura and Bussey dismissed central gender cognitions-gender identity and gender stereotype knowledge-despite considerable evidence in their support. Fourth, Bandura and Bussey never addressed the gaps and ambiguities inherent in their theory that Martin et al. questioned in their earlier article. Finally, Bandura and Bussey's misunderstandings of cognitive theorists' views on socialization agents, sociocultural influences, agency, and motivation created theoretical rifts where none exist. ((c) 2004 APA, all rights reserved)

Rangelands of Central Asia: Proceedings of the Conference on Transformations, Issues, and Future Challenges

Treesearch

Donald J. Bedunah; E. Durant McArthur; Maria Fernandez-Gimenez

2006-01-01

The 11 papers in this document address issues and needs in the development and stewardship of Central Asia rangelands, and identify directions for future work. With its vast rangelands and numerous pastoral populations, Central Asia is a region of increasing importance to rangeland scientists, managers, and pastoral development specialists. Five of the papers address...

Frequency and Content of Chat Questions by Time of Semester at the University of Central Florida: Implications for Training, Staffing and Marketing

ERIC Educational Resources Information Center

Goda, Donna; Bishop, Corinne

2008-01-01

The more than 4,000 "chats" received by the University of Central Florida's (UCF) Ask-A-Librarian digital reference service are the subject of this practitioner-based, descriptive case study. Question content from chats received during four semesters between January 2005 and May 2006 are categorized and plotted, by semester, to show the…

Using Student Writing and Lexical Analysis to Reveal Student Thinking about the Role of Stop Codons in the Central Dogma

ERIC Educational Resources Information Center

Prevost, Luanna B.; Smith, Michelle K.; Knight, Jennifer K.

2016-01-01

Previous work has shown that students have persistent difficulties in understanding how central dogma processes can be affected by a stop codon mutation. To explore these difficulties, we modified two multiple-choice questions from the Genetics Concept Assessment into three open-ended questions that asked students to write about how a stop codon…

Questions Addressed to V.V. Putin during an Internet Conference on Careers

ERIC Educational Resources Information Center

Agranovich, M.; Zair-Bek, S.; Seliverstova, I.; Shishmakova, E.

2007-01-01

On instructions from the Ministry of Education of the Russian Federation, the Federal Institute for the Development of Education prepared an analytical report on the topic "Questions Addressed to Russian President V.V. Putin During an Internet Conference on 6 July 2006 on the Problems of "Career"." That document presents an…

Family Investments in Low-Income Children's Achievement and Socioemotional Functioning

ERIC Educational Resources Information Center

Longo, Francesca; McPherran Lombardi, Caitlin; Dearing, Eric

2017-01-01

Family processes and parenting practices help explain developmental differences between children in low- versus higher-income households. There are, however, few studies addressing the question of: what are the key family processes and parenting practices for promoting low-income children's growth? We address this question in the present study,…

Cash transfers for HIV prevention: considering their potential.

PubMed

Heise, Lori; Lutz, Brian; Ranganathan, Meghna; Watts, Charlotte

2013-08-23

Cash payments to vulnerable households and/or individuals have increasingly garnered attention as a means to reduce poverty, improve health and achieve other development-related outcomes. Recent evidence from Malawi and Tanzania suggests that cash transfers can impact HIV-related behaviours and outcomes and, therefore, could serve as an important addition to HIV prevention efforts. This article reviews the current evidence on cash transfers for HIV prevention and suggests unresolved questions for further research. Gaps include (1) understanding more about the mechanisms and pathways through which cash transfers affect HIV-related outcomes; (2) addressing key operational questions, including the potential feasibility and the costs and benefits of different models of transfers and conditionality; and (3) evaluating and enhancing the wider impacts of cash transfers on health and development. Ongoing and future studies should build on current findings to unpack unresolved questions and to collect additional evidence on the multiple impacts of transfers in different settings. Furthermore, in order to address questions on sustainability, cash transfer programmes need to be integrated with other sectors and programmes that address structural factors such as education and programming to promote gender equality and address HIV.

Pesticide Labeling Questions & Answers

EPA Pesticide Factsheets

Pesticide manufacturers, applicators, state regulatory agencies, and other stakeholders raise questions or issues about pesticide labels. The questions on this page are those that apply to multiple products or address inconsistencies among product labels.

Engineering Social Justice into Traffic Control for Self-Driving Vehicles?

PubMed

Mladenovic, Milos N; McPherson, Tristram

2016-08-01

The convergence of computing, sensing, and communication technology will soon permit large-scale deployment of self-driving vehicles. This will in turn permit a radical transformation of traffic control technology. This paper makes a case for the importance of addressing questions of social justice in this transformation, and sketches a preliminary framework for doing so. We explain how new forms of traffic control technology have potential implications for several dimensions of social justice, including safety, sustainability, privacy, efficiency, and equal access. Our central focus is on efficiency and equal access as desiderata for traffic control design. We explain the limitations of conventional traffic control in meeting these desiderata, and sketch a preliminary vision for a next-generation traffic control tailored to address better the demands of social justice. One component of this vision is cooperative, hierarchically distributed self-organization among vehicles. Another component of this vision is a priority system enabling selection of priority levels by the user for each vehicle trip in the network, based on the supporting structure of non-monetary credits.

Planning and Design of Water Resources Systems Under Climate Change and Variability

NASA Astrophysics Data System (ADS)

Strzepek, K. M.

2014-12-01

Regional and local water supplies and demands are impacted by global and national systems: climate, economics, population and energy as well as policies: development, energy, and environmental. These drivers can result in complex interactions that require deeper understanding in order to provide actionable information for water planners and stakeholders to develop strategic plans in the face of a changing and growing world. To add more complexity to this issue is the fact that all these drivers are uncertain and the type of uncertainty is not the same. This talk will address approaches to Water Resource Planning at sub-national water regions, national levels and trans-boundary river basins under a non-stationary hydro-climatic future. Additionally the talk will address the design of specific water resource projects such as reservoirs and hydroplants that are being designed now but will operate far in the future when the hydro-climatology will be very different. Examples will be drawn from recent work in Africa, Eastern Europe and Central Asia, and North America and some insights and outstanding questions will be presented.

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.

PubMed

Sies, Helmut

2017-04-01

Hydrogen peroxide emerged as major redox metabolite operative in redox sensing, signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological settings as well as their biological consequences can now be addressed. The present overview focuses on recent progress on metabolic sources and sinks of H 2 O 2 and on the role of H 2 O 2 in redox signaling under physiological conditions (1-10nM), denoted as oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such as Nrf2/Keap1 or NF-κB. Supraphysiological concentrations of H 2 O 2 (>100nM) lead to damage of biomolecules, denoted as oxidative distress. Three questions are addressed: How can H 2 O 2 be assayed in the biological setting? What are the metabolic sources and sinks of H 2 O 2 ? What is the role of H 2 O 2 in redox signaling and oxidative stress? Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Emotion, philosophical issues about.

PubMed

Deonna, Julien; Tappolet, Christine; Teroni, Fabrice

2015-01-01

We start this overview by discussing the place of emotions within the broader affective domain-how different are emotions from moods, sensations, and affective dispositions? Next, we examine the way emotions relate to their objects, emphasizing in the process their intimate relations to values. We move from this inquiry into the nature of emotion to an inquiry into their epistemology. Do they provide reasons for evaluative judgments and, more generally, do they contribute to our knowledge of values? We then address the question of the social dimension of emotions, explaining how the traditional nature versus nurture contrast applies to them. We finish by exploring the relations between emotions, motivation and action, concluding this overview with a more specific focus on how these relations bear on some central ethical issues. © 2015 John Wiley & Sons, Ltd.

Force-controlled manipulation of single cells: from AFM to FluidFM.

PubMed

Guillaume-Gentil, Orane; Potthoff, Eva; Ossola, Dario; Franz, Clemens M; Zambelli, Tomaso; Vorholt, Julia A

2014-07-01

The ability to perturb individual cells and to obtain information at the single-cell level is of central importance for addressing numerous biological questions. Atomic force microscopy (AFM) offers great potential for this prospering field. Traditionally used as an imaging tool, more recent developments have extended the variety of cell-manipulation protocols. Fluidic force microscopy (FluidFM) combines AFM with microfluidics via microchanneled cantilevers with nano-sized apertures. The crucial element of the technology is the connection of the hollow cantilevers to a pressure controller, allowing their operation in liquid as force-controlled nanopipettes under optical control. Proof-of-concept studies demonstrated a broad spectrum of single-cell applications including isolation, deposition, adhesion and injection in a range of biological systems. Copyright © 2014 Elsevier Ltd. All rights reserved.

Social network analysis of a project-based introductory physics course

NASA Astrophysics Data System (ADS)

Oakley, Christopher

2016-03-01

Research suggests that students benefit from peer interaction and active engagement in the classroom. The quality, nature, effect of these interactions is currently being explored by Physics Education Researchers. Spelman College offers an introductory physics sequence that addresses content and research skills by engaging students in open-ended research projects, a form of Project-Based Learning. Students have been surveyed at regular intervals during the second semester of trigonometry-based course to determine the frequency of interactions in and out of class. These interactions can be with current or past students, tutors, and instructors. This line of inquiry focuses on metrics of Social Network analysis, such as centrality of participants as well as segmentation of groups. Further research will refine and highlight deeper questions regarding student performance in this pedagogy and course sequence.

Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop

PubMed Central

Sali, Andrej; Berman, Helen M.; Schwede, Torsten; Trewhella, Jill; Kleywegt, Gerard; Burley, Stephen K.; Markley, John; Nakamura, Haruki; Adams, Paul; Bonvin, Alexandre M.J.J.; Chiu, Wah; Dal Peraro, Matteo; Di Maio, Frank; Ferrin, Thomas E.; Grünewald, Kay; Gutmanas, Aleksandras; Henderson, Richard; Hummer, Gerhard; Iwasaki, Kenji; Johnson, Graham; Lawson, Catherine L.; Meiler, Jens; Marti-Renom, Marc A.; Montelione, Gaetano T.; Nilges, Michael; Nussinov, Ruth; Patwardhan, Ardan; Rappsilber, Juri; Read, Randy J.; Saibil, Helen; Schröder, Gunnar F.; Schwieters, Charles D.; Seidel, Claus A. M.; Svergun, Dmitri; Topf, Maya; Ulrich, Eldon L.; Velankar, Sameer; Westbrook, John D.

2016-01-01

Summary Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the first wwPDB Hybrid/Integrative Methods Task Force Workshop held at the European Bioinformatics Institute in Hinxton, UK, October 6 and 7, 2014. At the workshop, experts in various experimental fields of structural biology, experts in integrative modeling and visualization, and experts in data archiving addressed a series of questions central to the future of structural biology. How should integrative models be represented? How should the data and integrative models be validated? What data should be archived? How should the data and models be archived? What information should accompany the publication of integrative models? PMID:26095030

Physics of Cellular Movements

NASA Astrophysics Data System (ADS)

Sackmann, Erich; Keber, Felix; Heinrich, Doris

2010-04-01

The survival of cells depends on perpetual active motions, including (a) bending excitations of the soft cell envelopes, (b) the bidirectional transport of materials and organelles between the cell center and the periphery, and (c) the ongoing restructuring of the intracellular macromolecular scaffolds mediating global cell changes associated with cell adhesion locomotion and phagocytosis. Central questions addressed are the following: How can this bustling motion of extremely complex soft structures be characterized and measured? What are the major driving forces? Further topics include (a) the active dynamic control of global shape changes by the interactive coupling of the aster-like soft scaffold of microtubules and the network of actin filaments associated with the cell envelope (the actin cortex) and (b) the generation of propulsion forces by solitary actin gelation waves propagating within the actin cortex.

Masculinity and the persistence of AIDS stigma

PubMed Central

Wyrod, Robert

2011-01-01

With the expansion of access to HIV testing and antiretroviral therapy in sub-Saharan Africa, questions have emerged if stigma remains a useful concept for understanding the effects of AIDS. There is, however, a paucity of research on how HIV-positive Africans—especially African men—experience living with AIDS. This paper addresses this gap and draws on findings from ethnographic fieldwork in 2004 and 2009 with a support group for HIV-positive men in Kampala, Uganda. The paper demonstrates that stigma is central to how men in this context coped with HIV and AIDS, and it provides a conceptual framework that links men’s experiences of AIDS stigma to conceptions of masculinity. In so doing, findings highlight both the possibilities and challenges of involving African men more fully in HIV prevention. PMID:21246426

Recommended Screening Practices for Launch Collision Aviodance

NASA Technical Reports Server (NTRS)

Beaver, Brian A.; Hametz, Mark E.; Ollivierre, Jarmaine C.; Newman, Lauri K.; Hejduk, Matthew D.

2015-01-01

The objective of this document is to assess the value of launch collision avoidance (COLA) practices and provide recommendations regarding its implementation for NASA robotic missions. The scope of this effort is limited to launch COLA screens against catalog objects that are either spacecraft or debris. No modifications to manned safety COLA practices are considered in this effort. An assessment of the value of launch COLA can be broken down into two fundamental questions: 1) Does collision during launch represent a significant risk to either the payload being launched or the space environment? 2) Can launch collision mitigation be performed in a manner that provides meaningful risk reduction at an acceptable level of operational impact? While it has been possible to piece together partial answers to these questions for some time, the first attempt to comprehensively address them is documented in reference (a), Launch COLA Operations: an Examination of Data Products, Procedures, and Thresholds, Revision A. This report is the product of an extensive study that addressed fundamental technical questions surrounding launch collision avoidance analysis and practice. The results provided in reference (a) will be cited throughout this document as these two questions are addressed. The premise of this assessment is that in order to conclude that launch COLA is a value-added activity, the answer to both of these questions must be affirmative. A "no" answer to either of these questions points toward the conclusion that launch COLA provides little or no risk mitigation benefit. The remainder of this assessment will focus on addressing these two questions.

The Need for Systematic Reviews of Reasons

PubMed Central

Sofaer, Neema; Strech, Daniel

2012-01-01

There are many ethical decisions in the practice of health research and care, and in the creation of policy and guidelines. We argue that those charged with making such decisions need a new genre of review. The new genre is an application of the systematic review, which was developed over decades to inform medical decision-makers about what the totality of studies that investigate links between smoking and cancer, for example, implies about whether smoking causes cancer. We argue that there is a need for similarly inclusive and rigorous reviews of reason-based bioethics, which uses reasoning to address ethical questions. After presenting a brief history of the systematic review, we reject the only existing model for writing a systematic review of reason-based bioethics, which holds that such a review should address an ethical question. We argue that such a systematic review may mislead decision-makers when a literature is incomplete, or when there are mutually incompatible but individually reasonable answers to the ethical question. Furthermore, such a review can be written without identifying all the reasons given when the ethical questions are discussed, their alleged implications for the ethical question, and the attitudes taken to the reasons. The reviews we propose address instead the empirical question of which reasons have been given when addressing a specified ethical question, and present such detailed information on the reasons. We argue that this information is likely to improve decision-making, both directly and indirectly, and also the academic literature. We explain the limitations of our alternative model for systematic reviews. PMID:21521251

Dimensions of Questioning: A Qualitative Study of Current Classroom Practice in Malaysia

ERIC Educational Resources Information Center

Hussin, Habsah

2006-01-01

This study investigated questioning as practiced in Malaysian secondary school classrooms, to determine teachers' rationale for adopting certain techniques of questioning, and to use the findings to inform teacher education. Questioning is a central aspect of any classroom interaction as it serves so many functions but it is still an…

A new organismal systems biology: how animals walk the tight rope between stability and change.

PubMed

Padilla, Dianna K; Tsukimura, Brian

2014-07-01

The amount of knowledge in the biological sciences is growing at an exponential rate. Simultaneously, the incorporation of new technologies in gathering scientific information has greatly accelerated our capacity to ask, and answer, new questions. How do we, as organismal biologists, meet these challenges, and develop research strategies that will allow us to address the grand challenge question: how do organisms walk the tightrope between stability and change? Organisms and organismal systems are complex, and multi-scale in both space and time. It is clear that addressing major questions about organismal biology will not come from "business as usual" approaches. Rather, we require the collaboration of a wide range of experts and integration of biological information with more quantitative approaches traditionally found in engineering and applied mathematics. Research programs designed to address grand challenge questions will require deep knowledge and expertise within subfields of organismal biology, collaboration and integration among otherwise disparate areas of research, and consideration of organisms as integrated systems. Our ability to predict which features of complex integrated systems provide the capacity to be robust in changing environments is poorly developed. A predictive organismal biology is needed, but will require more quantitative approaches than are typical in biology, including complex systems-modeling approaches common to engineering. This new organismal systems biology will have reciprocal benefits for biologists, engineers, and mathematicians who address similar questions, including those working on control theory and dynamical systems biology, and will develop the tools we need to address the grand challenge questions of the 21st century. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Tobacco counter-advertising: a review of the literature and a conceptual model for understanding effects.

PubMed

Agostinelli, Gina; Grube, Joel W

2003-01-01

The tobacco counter-advertising literature is reviewed as it relates to basic process questions concerning what makes counter-advertisements effective. Limitations in addressing (a) counter-advertisement content and the psychological mediators targeted, (b) counter-advertisement style and the affective reactions targeted, (c) prior smoking experience, and (d) other audience factors are enumerated. A theoretical model based on alcohol advertising research is presented to address those limitations. The model addresses the practical research question of predicting when tobacco counter-advertising will work by examining the independent influence of each of these enumerated factors, as well as how these factors operate in concert, qualifying each other. The model also addresses the process question of explaining how counter-advertising works by identifying affective and cognitive processes as mediators. By understanding the processes that underlie the qualified findings, one can better advise the designers of tobacco counter-advertisements how to be more effective.

Constraining the Single-degenerate Channel of Type Ia Supernovae with Stable Iron-group Elements in SNR 3C 397

NASA Astrophysics Data System (ADS)

Dave, Pranav; Kashyap, Rahul; Fisher, Robert; Timmes, Frank; Townsley, Dean; Byrohl, Chris

2017-05-01

Recent Suzaku X-ray spectra of supernova remnant (SNR) 3C 397 indicate enhanced stable iron group element abundances of Ni, Mn, Cr, and Fe. Seeking to address key questions about the progenitor and explosion mechanism of 3C 397, we compute nucleosynthetic yields from a suite of multidimensional hydrodynamics models in the near-Chandrasekhar-mass, single-degenerate paradigm for Type Ia supernovae (SNe Ia). Varying the progenitor white dwarf (WD) internal structure, composition, ignition, and explosion mechanism, we find that the best match to the observed iron peak elements of 3C 397 are dense (central density ≥6 × 109 g cm-3), low-carbon WDs that undergo a weak, centrally ignited deflagration, followed by a subsequent detonation. The amount of 56Ni produced is consistent with a normal or bright normal SNe Ia. A pure deflagration of a centrally ignited, low central density (≃2 × 109 g cm-3) progenitor WD, frequently considered in the literature, is also found to produce good agreement with 3C 397 nucleosynthetic yields, but leads to a subluminous SN Ia event, in conflict with X-ray line width data. Additionally, in contrast to prior work that suggested a large supersolar metallicity for the WD progenitor for SNR 3C 397, we find satisfactory agreement for solar- and subsolar-metallicity progenitors. We discuss a range of implications our results have for the single-degenerate channel.

Inability of Ceratitis capitata (Diptera: Tephritidae) to overwinter in the Judean hills.

PubMed

Israely, Nimrod; Ritte, Uzi; Oman, Samuel D

2004-02-01

The overwintering potential of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), in cold winter areas within its northern distribution is a key element in understanding its ecology. Recent studies have suggested that although originating in tropical Africa, the fly has become adapted to the cold weather that prevails within its northernmost areas of distribution. We address the question of whether the Mediterranean fruit fly has expanded its overwintering range to include the mountains of central Israel. Doing so would imply that the fly has developed either a behavioral or a physiological mechanism to cope with low temperature and/or damp conditions in combination with cold. We monitored adult populations year round, sampling fruit, calculating expected emergence days for overwintering flies, and studying adults captured within dense and sparse apple orchards. We also performed several manipulative experiments to study preimago ability to survive the winter under natural or seminatural conditions. The study was conducted in the central mountains of Israel at 700-m altitude from 1994 to 2003. Comparison experiments also were conducted at 400 m and at sea level. Our results show 1) no adults captured during the winter and spring, 2) an absence of new infestations during the winter and spring, and 3) inability of preimago stages to overwinter in the central mountains of Israel. Thus, we conclude that the fly does not overwinter in the central mountains of Israel. We discuss the ecological and applied significance of our findings.

Test Pool Questions, Area III.

ERIC Educational Resources Information Center

Sloan, Jamee Reid

This manual contains multiple choice questions to be used in testing students on nurse training objectives. Each test includes several questions covering each concept. The concepts in section A, medical surgical nursing, are diseases of the following systems: musculoskeletal; central nervous; cardiovascular; gastrointestinal; urinary and male…

Educational Choice: Practical Policy Questions. Occasional Paper Series No. 7.

ERIC Educational Resources Information Center

First, Patricia F.

The consideration of school choice plans raises policy questions for school administrators. This paper addresses pragmatic concerns about definitions and policy questions related to educational finance. Interdistrict choice, emphasizing families' right to choose among existing public schools, raises questions regarding transportation and…

Northwest Forest Plan—the first 10 years (1994–2003): socioeconomic monitoring results.

Treesearch

S. Charnley

2006-01-01

The socioeconomic monitoring report addresses two evaluation questions posed in the Northwest Forest Plan (the Plan) Record of Decision and assesses progress in meeting five Plan socioeconomic goals. Volume I of the report contains key findings. Volume II addresses the question, Are predictable levels of timber and nontimber resources available and being produced? It...

Unfolding the Cosmos or Divining "What's up?"

ERIC Educational Resources Information Center

Saxton, Juliana

2010-01-01

This short paper considers the question: what of the future of drama in education? It suggests that perhaps, because we are artists, the future is already in play. If that is so, then we need to address those questions of value, advocacy and marginalisation more rigorously while, at the same time, addressing the impact of technology on empathic…

Analysis of Naval NETWAR FORCEnet Enterprise: Implications for Capabilities Based Budgeting

DTIC Science & Technology

2006-12-01

of this background information and projecting how ADNS is likely to succeed in the NNFE framework , two fundamental research questions were addressed...background information and projecting how ADNS is likely to succeed in the NNFE framework , two fundamental research questions were addressed. The...Business Approach ......................................................26 Figure 8. Critical Assumption for Common Analytical Framework

Evaluation of Three Microcomputer Teaching Modules. SUMIT Courseware Development Project.

ERIC Educational Resources Information Center

Soldan, Ted

The purpose of this series of experiments was to examine two questions related to the effectiveness of computer assisted instruction (CAI). Can microcomputer modules teach effectively, and do they enhance learning when used as a supplement to traditional teaching methods? Part 1 of this report addresses the former question and part 2 addresses the…

UAS Integration in the NAS Project: DAA-TCAS Interoperability "mini" HITL Primary Results

NASA Technical Reports Server (NTRS)

Rorie, Conrad; Fern, Lisa; Shively, Jay; Santiago, Confesor

2016-01-01

At the May 2015 SC-228 meeting, requirements for TCAS II interoperability became elevated in priority. A TCAS interoperability workgroup was formed to identify and address key issues/questions. The TCAS workgroup came up with an initial list of questions and a plan to address those questions. As part of that plan, NASA proposed to run a mini HITL to address display, alerting and guidance issues. A TCAS Interoperability Workshop was held to determine potential display/alerting/guidance issues that could be explored in future NASA mini HITLS. Consensus on main functionality of DAA guidance when TCAS II RA occurs. Prioritized list of independent variables for experimental design. Set of use cases to stress TCAS Interoperability.

Network Connectedness, Sense of Community, and Risk Perception of Climate Change Professionals in the Pacific Islands Region

NASA Astrophysics Data System (ADS)

Corlew, L. K.; Keener, V. W.; Finucane, M.

2013-12-01

The Pacific Regional Integrated Sciences and Assessments (Pacific RISA) Program conducted social network analysis research of climate change professionals (broadly defined) who are from or work in Hawaii and the U.S.-Affiliated Pacific Islands (USAPI) region. This study is supported by the National Oceanic and Atmospheric Administration (NOAA) and the Pacific Islands Climate Science Center (PICSC) to address an identified need for a resource that quantifies the region's collaborative network of climate change professionals, and that supports the further development of cross-regional and inter-sectoral collaborations for future research and adaptation activities. A survey was distributed to nearly 1,200 people who are from and/or work in climate change related fields in the region. The Part One Survey questions (not confidential) created a preferential attachment network by listing major players in Hawaii and the USAPI, with additional open fields to identify important contacts in the greater professional network. Participants (n=340) identified 975 network contacts and frequency of communications (weekly, monthly, seasonally, yearly, at least once ever). Part Two Survey questions (confidential, n=302) explored climate change risk perceptions, Psychological Sense of Community (PSOC), sense of control over climate change impacts, sense of responsibility to act, policy beliefs and preferences regarding climate change actions, concern and optimism scales about specific impacts, and demographic information. Graphical representations of the professional network are being developed for release in September 2013 as a free online tool to promote and assist collaboration building among climate professionals in the region. The graphs are partitioned according to network 'hubs' (high centrality), participant location, and profession to clearly identify network strengths and opportunities for future collaborations across spatial and professional boundaries. For additional analyses, scores are assigned for participant degree centrality, betweenness centrality, and Eigenvector centrality from the Part One Survey, as well as PSOC, control, responsibility, risk perceptions, concern, optimism, and policy preferences from the Part Two Survey. Statistical interaction analyses explore factors motivating connectedness within the network, as well as climate change research and adaptation needs and priorities of participants.

Distinguishing among Declarative, Descriptive and Causal Questions to Guide Field Investigations and Student Assessment

ERIC Educational Resources Information Center

Odom, Arthur Louis; Bell, Clare V.

2011-01-01

Teachers as well as students often have difficulty formulating good research questions because not all questions lend themselves to scientific investigation. The following is a guide for high-school and college life-science teachers to help students define question types central to biological field studies. The mayfly nymph was selected as the…

Questions Asked by Primary Student Teachers about Observations of a Science Demonstration

ERIC Educational Resources Information Center

Ahtee, Maija; Juuti, Kalle; Lavonen, Jari; Suomela, Liisa

2011-01-01

Teacher questioning has a central role in guiding pupils to learn to make scientific observations and inferences. We asked 110 primary student teachers to write down what kind of questions they would ask their pupils about a demonstration. Almost half of the student teachers posed questions that were either inappropriate or presupposed that the…

Clumped Isotope Thermometry Reveals Variations in Soil Carbonate Seasonal Biases Over >4 km of Relief in the Semi-Arid Andes of Central Chile

NASA Astrophysics Data System (ADS)

Burgener, L. K.; Huntington, K. W.; Hoke, G. D.; Schauer, A. J.; Ringham, M. C.; Latorre Hidalgo, C.; Díaz, F.

2015-12-01

The application of carbonate clumped isotope thermometry to soil carbonates has the potential to shed new light on questions regarding terrestrial paleoclimate. In order to better utilize this paleoclimate tool, outstanding questions regarding seasonal biases in soil carbonate formation and the relationship between soil carbonate formation temperatures (T(Δ47)) and surface temperatures must be resolved. We address these questions by comparing C, O, and clumped isotope data from Holocene/modern soil carbonates to modern meteorological data. The data were collected along a 170 km transect with >4 km of relief in central Chile (~30°S). Previous studies have suggested that soil carbonates should record a warm season bias and form in isotopic equilibrium with soil water and soil CO2. We identify two discrete climate zones separated by the local winter snow line (~3200 m). Below this boundary, precipitation falls as rain and soil carbonate T(Δ47) values at depths >40 cm resemble summer soil temperatures; at higher elevations, precipitation falls as snow and T(Δ47) values resemble mean annual soil temperatures. Soil carbonates from the highest sample site (4700 m), which is devoid of vegetation and located near perennial snow fields, yield anomalous δ18O, δ13C, and T(Δ47) values, indicative of kinetic isotope effects that we attribute to cryogenic carbonate formation. Our results suggest that soil carbonates from depths <40 cm are affected by large, high frequency variations in temperature and precipitation, and should not be used as paleotemperature proxies. These findings (1) highlight the role of soil moisture in modulating soil carbonate formation and the resulting T(Δ47) values, (2) underscore the importance of understanding past soil moisture conditions when attempting to reconstruct paleotemperatures using carbonate clumped isotope thermometry, and (3) suggest that soil carbonates from high elevation or high latitude sites may form under non-equilibrium conditions.

The Black-White Achievement Gap through the Lens of Central Office Administrators

ERIC Educational Resources Information Center

Baskin, Roger S., Sr.

2013-01-01

This study investigated the perceptions of Black and White central office administrators regarding the Black-White achievement gap. Four research questions (RQ) were explored: RQ1: How do central office administrators understand the causes of the Black-White achievement gap? RQ2: How do central office administrators perceive their role in…

Good Student Questions in Inquiry Learning

ERIC Educational Resources Information Center

Lombard, François E.; Schneider, Daniel K.

2013-01-01

Acquisition of scientific reasoning is one of the big challenges in education. A popular educational strategy advocated for acquiring deep knowledge is inquiry-based learning, which is driven by emerging "good questions". This study will address the question: "Which design features allow learners to refine questions while preserving…

Binary Black Holes, Accretion Disks and Relativistic Jets: Photocenters of Nearby AGN and Quasars

NASA Technical Reports Server (NTRS)

Wehrle, Ann E.; Jones, Dayton L.; Meier, David L.; Piner, B. Glenn; Unwin, Stephen C.

2004-01-01

One of the most challenging questions in astronomy today is to understand the origin, structure, and evolution of the central engines in the nuclei of quasars and active galaxies (AGNs). The favoured theory involves the activation of relativistic jets from the fueling of a supermassive black hole through an accretion disk. In some AGN an outer optically thick, dusty torus is seen orbiting the black hole system. This torus is probably related to an inner accretion disk - black hole system that forms the actual powerhouse of the AGN. In radio-loud AGN two oppositely-directed radio jets are ejected perpendicular to the torus/disk system. Although there is a wealth of observational data on AGN, some very basic questions have not been definitively answered. The Space Interferometry Mission (SIM) will address the following three key questions about AGN. 1) Does the most compact optical emission from an AGN come from an accretion disk or from a relativistic jet? 2) Does the separation of the radio core and optical photocenter of the quasars used for the reference frame tie, change on the timescales of their photometric variability, or is the separation stable at the level of a few microarcseconds? 3) Do the cores of galaxies harbor binary supermassive black holes remaining from galaxy mergers? It is not known whether such mergers are common, and whether binaries would persist for a significant time.

Surgical management of gastroesophageal reflux disease (GERD) in children: A systematic review.

PubMed

Jancelewicz, Tim; Lopez, Monica E; Downard, Cynthia D; Islam, Saleem; Baird, Robert; Rangel, Shawn J; Williams, Regan F; Arnold, Meghan A; Lal, Dave; Renaud, Elizabeth; Grabowski, Julia; Dasgupta, Roshni; Austin, Mary; Shelton, Julia; Cameron, Danielle; Goldin, Adam B

2017-08-01

The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to derive recommendations from the medical literature regarding the surgical treatment of pediatric gastroesophageal reflux disease (GERD). Five questions were addressed by searching the MEDLINE, Cochrane, Embase, Central, and National Guideline Clearinghouse databases using relevant search terms. Consensus recommendations were derived for each question based on the best available evidence. There was insufficient evidence to formulate recommendations for all questions. Fundoplication does not affect the rate of hospitalization for aspiration pneumonia, apnea, or reflux-related symptoms. Fundoplication is effective in reducing all parameters of esophageal acid exposure without altering esophageal motility. Laparoscopic fundoplication may be comparable to open fundoplication with regard to short-term clinical outcomes. Partial fundoplication and complete fundoplication are comparable in effectiveness for subjective control of GERD. Fundoplication may benefit GERD patients with asthma, but may not improve outcomes in patients with neurologic impairment or esophageal atresia. Overall GERD recurrence rates are likely below 20%. High-quality evidence is lacking regarding the surgical management of GERD in the pediatric population. Definitive conclusions regarding the effectiveness of fundoplication are limited by patient heterogeneity and lack of a standardized outcomes reporting framework. Systematic review of level 1-4 studies. Level 1-4 (mainly level 3-4). Copyright © 2017 Elsevier Inc. All rights reserved.

New palaeomagnetic data from Argun terrane. Testing its association with Amuria and the Mongol-Okhotsk Ocean

NASA Astrophysics Data System (ADS)

Gordienko, I. V.; Metelkin, D. V.; Vetluzhskikh, L. I.; Mikhaltsov, N. E.; Kulakov, E. V.

2018-06-01

In this study, we present new palaeomagnetic and geological data obtained from Ediacaran and Cambrian sedimentary rocks of Argun terrane, which is traditionally considered a key element of the hypothetical Amuria composite continent. Since 1990, when Amuria was first proposed in palaeogeographic reconstructions, it became one of the principle members in the global palaeotectonic schemes. A scenario when collision of Amuria with Siberian margin resulted in formation of the Mongol-Okhotsk Ocean is universally accepted and supported by majority of researchers. However, time of Amuria's final assembly and relative position of the blocks within Amuria before the collision with Siberia is still a topic of debate. Questions about principal allocation of Argun terrane and its relation to Amuria during the late Neoroterozoic-Cambrian are addressed in this study. Palaeomagnetic poles for the Ediacaran-early Cambrian rocks of Argun terrane differ within an error from coeval poles from Siberia indicating that Argun terrane could have been located similar to its present-day position with respect to Siberia already at 560-525 Ma. This observation calls into question association of Argun terrane with Amuria, which in classic reconstructions is usually placed close to the North China Craton. It also questions our current understanding of the Amuria palaeocontinent and consequently, accuracy of global palaeogeographic reconstructions for the late Neoproterozoic-Cambrian in general, and those of the eastern part of the Central Asia in particular.

Leadership theory: implications for developing dental surgeons in primary care?

PubMed

Willcocks, S

2011-02-12

The development of leadership in healthcare has been seen as important in recent years, particularly at the clinical level. There have been various specific initiatives focusing on the development of leadership for doctors, nurses and other health care professions: for example, a leadership competency framework for doctors, the LEO programme and the RCN clinical leadership programme for nurses. The NHS has set up a Leadership Council to coordinate further developments. However, there has not been the same focus in dentistry, although the recent review of NHS dental services (Steele review) has proposed a need for leadership initiatives in NHS dentistry as a medium-term action. Central to this will be a need to focus on the leadership role for dental surgeons. Leadership is all the more important in dentistry, given the change of government and the policy of retrenchment, major public sector reform, the emergence of new organisations such as new commissioning consortia, possible changes to the dental contract, new ways of working, and changes to the profession such as the requirements for the revalidation of dental surgeons. The question is: which leadership theory or approach is best for dental surgeons working in primary care? This paper builds on earlier work exploring this question in relation to doctors generally, and GPs, in particular, and planned work on nurses. It will seek to address this question in relation to dental surgeons working in primary care.

The value of value of information: best informing research design and prioritization using current methods.

PubMed

Eckermann, Simon; Karnon, Jon; Willan, Andrew R

2010-01-01

Value of information (VOI) methods have been proposed as a systematic approach to inform optimal research design and prioritization. Four related questions arise that VOI methods could address. (i) Is further research for a health technology assessment (HTA) potentially worthwhile? (ii) Is the cost of a given research design less than its expected value? (iii) What is the optimal research design for an HTA? (iv) How can research funding be best prioritized across alternative HTAs? Following Occam's razor, we consider the usefulness of VOI methods in informing questions 1-4 relative to their simplicity of use. Expected value of perfect information (EVPI) with current information, while simple to calculate, is shown to provide neither a necessary nor a sufficient condition to address question 1, given that what EVPI needs to exceed varies with the cost of research design, which can vary from very large down to negligible. Hence, for any given HTA, EVPI does not discriminate, as it can be large and further research not worthwhile or small and further research worthwhile. In contrast, each of questions 1-4 are shown to be fully addressed (necessary and sufficient) where VOI methods are applied to maximize expected value of sample information (EVSI) minus expected costs across designs. In comparing complexity in use of VOI methods, applying the central limit theorem (CLT) simplifies analysis to enable easy estimation of EVSI and optimal overall research design, and has been shown to outperform bootstrapping, particularly with small samples. Consequently, VOI methods applying the CLT to inform optimal overall research design satisfy Occam's razor in both improving decision making and reducing complexity. Furthermore, they enable consideration of relevant decision contexts, including option value and opportunity cost of delay, time, imperfect implementation and optimal design across jurisdictions. More complex VOI methods such as bootstrapping of the expected value of partial EVPI may have potential value in refining overall research design. However, Occam's razor must be seriously considered in application of these VOI methods, given their increased complexity and current limitations in informing decision making, with restriction to EVPI rather than EVSI and not allowing for important decision-making contexts. Initial use of CLT methods to focus these more complex partial VOI methods towards where they may be useful in refining optimal overall trial design is suggested. Integrating CLT methods with such partial VOI methods to allow estimation of partial EVSI is suggested in future research to add value to the current VOI toolkit.

How Did the Information Flow in the #AlphaGo Hashtag Network? A Social Network Analysis of the Large-Scale Information Network on Twitter.

PubMed

Kim, Jinyoung

2017-12-01

As it becomes common for Internet users to use hashtags when posting and searching information on social media, it is important to understand who builds a hashtag network and how information is circulated within the network. This article focused on unlocking the potential of the #AlphaGo hashtag network by addressing the following questions. First, the current study examined whether traditional opinion leadership (i.e., the influentials hypothesis) or grassroot participation by the public (i.e., the interpersonal hypothesis) drove dissemination of information in the hashtag network. Second, several unique patterns of information distribution by key users were identified. Finally, the association between attributes of key users who exerted great influence on information distribution (i.e., the number of followers and follows) and their central status in the network was tested. To answer the proffered research questions, a social network analysis was conducted using a large-scale hashtag network data set from Twitter (n = 21,870). The results showed that the leading actors in the network were actively receiving information from their followers rather than serving as intermediaries between the original information sources and the public. Moreover, the leading actors played several roles (i.e., conversation starters, influencers, and active engagers) in the network. Furthermore, the number of their follows and followers were significantly associated with their central status in the hashtag network. Based on the results, the current research explained how the information was exchanged in the hashtag network by proposing the reciprocal model of information flow.

Fishery management, development and food security in the Western and Central Pacific in the context of climate change

NASA Astrophysics Data System (ADS)

Weng, Kevin C.; Glazier, Ed; Nicol, Simon J.; Hobday, Alistair J.

2015-03-01

In the coming decades, fishery resource managers and policy-makers in Pacific Island countries and territories (PICTs) will be increasingly challenged by the need to ensure food security in the context of a changing climate, increasing human pressure on the marine environment, and limited understanding of marine ecosystems and associated resources. These decision-makers must address a pressing and overarching question - how will pelagic resources and pressures on such resources change over time and space? Answering this question requires ongoing inquiry into critical dimensions of pelagic species and systems, for both the commercial tuna species that are managed by Regional Fishery Management Organizations (RFMOs), as well as nearshore pelagic fishes that support many small-scale fisheries and are managed at national and local levels. Research priorities include generating further insight into life history and physiology, oceanographic context, movement and migration, food webs, ecosystem dynamics and stock status. Concurrently, socioeconomic research is needed to tailor fisheries management strategies to local, national and regional conditions; and improve understanding of incentive structures among players in RFMOs such as the Western and Central Pacific Fisheries Commission. PICT-based scientists and managers are ideally situated to generate new fisheries-relevant data; however, investments are needed to expand the capacity for research, management, and sustainable fisheries development within PICTs. Such capacity building can be accelerated through collaboration between PICTs, RFMOs, and scientific centers of excellence in Distant Water Fishing Nations. Without increased capacity development, this region will be adversely affected by the impacts of climate change and less able to take advantage of opportunities for economic development.

An evidence-based clinical guideline for the use of antithrombotic therapies in spine surgery.

PubMed

Bono, Christopher M; Watters, William C; Heggeness, Michael H; Resnick, Daniel K; Shaffer, William O; Baisden, Jamie; Ben-Galim, Peleg; Easa, John E; Fernand, Robert; Lamer, Tim; Matz, Paul G; Mendel, Richard C; Patel, Rajeev K; Reitman, Charles A; Toton, John F

2009-12-01

The objective of the North American Spine Society (NASS) Evidence-Based Clinical Guideline on antithrombotic therapies in spine surgery was to provide evidence-based recommendations to address key clinical questions surrounding the use of antithrombotic therapies in spine surgery. The guideline is intended to address these questions based on the highest quality clinical literature available on this subject as of February 2008. The goal of the guideline recommendations was to assist in delivering optimum, efficacious treatment with the goal of preventing thromboembolic events. To provide an evidence-based, educational tool to assist spine surgeons in minimizing the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE). Systematic review and evidence-based clinical guideline. This report is from the Antithrombotic Therapies Work Group of the NASS Evidence-Based Guideline Development Committee. The work group was composed of multidisciplinary spine care specialists, all of whom were trained in the principles of evidence-based analysis. Each member of the group was involved in formatting a series of clinical questions to be addressed by the group. The final questions agreed on by the group are the subject of this report. A literature search addressing each question and using a specific search protocol was performed on English language references found in MEDLINE, EMBASE (Drugs and Pharmacology), and four additional, evidence-based databases. The relevant literature was then independently rated by at least three reviewers using the NASS-adopted standardized levels of evidence. An evidentiary table was created for each of the questions. Final grades of recommendation for the answers to each clinical question were arrived at via Web casts among members of the work group using standardized grades of recommendation. When Level I to IV evidence was insufficient to support a recommendation to answer a specific clinical question, expert consensus was arrived at by the work group through the modified nominal group technique and is clearly identified as such in the guideline. Fourteen clinical questions were formulated, addressing issues of incidence of DVT and PE in spine surgery and recommendations regarding utilization of mechanical prophylaxis and chemoprophylaxis in spine surgery. The answers to these 14 clinical questions are summarized in this article. The respective recommendations were graded by the strength of the supporting literature that was stratified by levels of evidence. A clinical guideline addressing the use of antithrombotic therapies in spine surgery has been created using the techniques of evidence-based medicine and using the best available evidence as a tool to assist spine surgeons in minimizing the risk of DVT and PE. The entire guideline document, including the evidentiary tables, suggestions for future research, and all references, is available electronically at the NASS Web site (www.spine.org) and will remain updated on a timely schedule.

Community Problems in Five West Central Counties. Report No. 7 of a Series on Quality of Life and Development in Northwestern Wisconsin, February 1976.

ERIC Educational Resources Information Center

Lambert, Virginia; Linn, Gary

As part of a study on development and the quality of life in northwestern Wisconsin, questions concerning important problems, public services, and environmental issues were asked of samples of 150 people in each of 4 west central counties (Clark, Dunn, Eau Claire, and Polk) in 1974. Responses to similar questions asked in a 1973 study of St. Croix…

Multisensory perceptual learning of temporal order: audiovisual learning transfers to vision but not audition.

PubMed

Alais, David; Cass, John

2010-06-23

An outstanding question in sensory neuroscience is whether the perceived timing of events is mediated by a central supra-modal timing mechanism, or multiple modality-specific systems. We use a perceptual learning paradigm to address this question. Three groups were trained daily for 10 sessions on an auditory, a visual or a combined audiovisual temporal order judgment (TOJ). Groups were pre-tested on a range TOJ tasks within and between their group modality prior to learning so that transfer of any learning from the trained task could be measured by post-testing other tasks. Robust TOJ learning (reduced temporal order discrimination thresholds) occurred for all groups, although auditory learning (dichotic 500/2000 Hz tones) was slightly weaker than visual learning (lateralised grating patches). Crossmodal TOJs also displayed robust learning. Post-testing revealed that improvements in temporal resolution acquired during visual learning transferred within modality to other retinotopic locations and orientations, but not to auditory or crossmodal tasks. Auditory learning did not transfer to visual or crossmodal tasks, and neither did it transfer within audition to another frequency pair. In an interesting asymmetry, crossmodal learning transferred to all visual tasks but not to auditory tasks. Finally, in all conditions, learning to make TOJs for stimulus onsets did not transfer at all to discriminating temporal offsets. These data present a complex picture of timing processes. The lack of transfer between unimodal groups indicates no central supramodal timing process for this task; however, the audiovisual-to-visual transfer cannot be explained without some form of sensory interaction. We propose that auditory learning occurred in frequency-tuned processes in the periphery, precluding interactions with more central visual and audiovisual timing processes. Functionally the patterns of featural transfer suggest that perceptual learning of temporal order may be optimised to object-centered rather than viewer-centered constraints.

Variable frequency microprocessor clock generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Branson, C.N.

A microprocessor-based system is described comprising: a digital central microprocessor provided with a clock input and having a rate of operation determined by the frequency of a clock signal input thereto; memory means operably coupled to the central microprocessor for storing programs respectively including a plurality of instructions and addressable by the central microprocessor; peripheral device operably connected to the central microprocessor, the first peripheral device being addressable by the central microprocessor for control thereby; a system clock generator for generating a digital reference clock signal having a reference frequency rate; and frequency rate reduction circuit means connected between themore » clock generator and the clock input of the central microprocessor for selectively dividing the reference clock signal to generate a microprocessor clock signal as an input to the central microprocessor for clocking the central microprocessor.« less

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Questions and Answers for Reporting for the 2006 Partial Updating of the TSCA Chemical Inventory Database: Inorganic Chemicals Addendum

EPA Pesticide Factsheets

This document addresses specific questions related to reporting inorganic chemicals under the IUR and is an addendum to the Questions and Answers for Reporting for the 2006 Partial Updating of the TSCA Chemical Inventory Database (Questions and Answers Document).

Key Questions for Reviewing Virtual Charter School Proposals

ERIC Educational Resources Information Center

National Association of Charter School Authorizers (NJ1), 2011

2011-01-01

This document contains key questions to consider when evaluating virtual charter school proposals.The insert is designed to help authorizers evaluate school quality and capacity in light of the distinctive attributes of virtual schooling. These questions address major functional areas as well essential questions that authorizers should ask of…

Central Contractor Registration Handbook (CCR)

DTIC Science & Technology

2002-03-01

Assistance Center 888-227-2423 or 616-961-4725 Report Documentation Page Report Date 00/03/2002 Report Type N/A Dates Covered (from... to) - Title and......Work Unit Number Performing Organization Name(s) and Address(es) Central Contractor Registration Assistance Center (888-227-2423) or (616-961-4725

Nurturing Leadership: Equitable Mentoring for the Superintendency

ERIC Educational Resources Information Center

Muñoz, Ava J.; Pankake, Anita M.; Mills, Shirley; Simonsson, Marie

2018-01-01

Why is it that so many women seem to climb the administrative ladder leading to the superintendency frequently and with relative ease, but do not reach that top rung? Data to help address this question is presented here. These data are part of a larger research project completed in the fall of 2006. In addressing this question, an overview of the…

Teaching Writing: Some Perennial Questions and Some Possible Answers. Occasional Paper No. 85.

ERIC Educational Resources Information Center

Florio-Ruane, Susan; Dunn, Saundra

Based on the premise that writing research will be useful to educators only to the extent that it offers them conceptual tools to use in framing and solving their own problems, this paper reviews studies that address educators' perennial concerns about writing instruction. Among the questions addressed in the paper are those concerning (1) the…

Student and Early Career Mobility Patterns among Highly Educated People in Germany, Finland, Italy, and the United Kingdom

ERIC Educational Resources Information Center

Lindberg, Matti E.

2009-01-01

This article addresses the question of how great are higher education students' incentives to change study programs or institutions to improve one's personal employability in the course of the higher education-to-work transition process. The posed question is addressed at a system level. Students' mobility between programs and institutions is…

Upper secondary and first-year university students' explanations of animal behaviour: to what extent are Tinbergen's four questions about causation, ontogeny, function and evolution, represented?

NASA Astrophysics Data System (ADS)

Pinxten, Rianne; Desclée, Mathieu; Eens, Marcel

2016-09-01

In 1963, the Nobel Prize-winning ethologist Niko Tinbergen proposed a framework for the scientific study of animal behaviour by outlining four questions that should be answered to have a complete understanding: causation, ontogeny, function and evolution. At present, Tinbergen's framework is still considered the best way to guide animal behavioural research. Given the importance in science instruction of demonstrating how scientists work and ask questions, we investigated to what extent Tinbergen's questions are addressed in biology textbooks in secondary education in Flanders, Belgium, and represented in upper-secondary and first-year university students' explanations of behaviour in general and of specific animal behaviours. Our results revealed that teaching of animal behaviour mainly addresses ontogeny and causation, and that Tinbergen's framework is not explicitly referred to. Students typically addressed only one or two questions, with the majority addressing causation or both causation and ontogeny when explaining behaviour in general, but function or causation and function when explaining specific animal behaviours. This high prevalence of function may be due to teleological thinking. Evolution was completely neglected, even in university students who had recently completed an evolution course. Our results revealed that transfer of the concepts of ontogeny and evolution was (almost) absent. We argue why Tinbergen's framework should be an integral part of any biology curriculum.

Utilizing social media to study information-seeking and ethical issues in gene therapy.

PubMed

Robillard, Julie M; Whiteley, Louise; Johnson, Thomas Wade; Lim, Jonathan; Wasserman, Wyeth W; Illes, Judy

2013-03-04

The field of gene therapy is rapidly evolving, and while hopes of treating disorders of the central nervous system and ethical concerns have been articulated within the academic community, little is known about views and opinions of different stakeholder groups. To address this gap, we utilized social media to investigate the kind of information public users are seeking about gene therapy and the hopes, concerns, and attitudes they express. We conducted a content analysis of questions containing the keywords "gene therapy" from the Q&A site "Yahoo! Answers" for the 5-year period between 2006 and 2010. From the pool of questions retrieved (N=903), we identified those containing at least one theme related to ethics, environment, economics, law, or society (n=173) and then characterized the content of relevant answers (n=399) through emergent coding. The results show that users seek a wide range of information regarding gene therapy, with requests for scientific information and ethical issues at the forefront of enquiry. The question sample reveals high expectations for gene therapy that range from cures for genetic and nongenetic diseases to pre- and postnatal enhancement of physiological attributes. Ethics questions are commonly expressed as fears about the impact of gene therapy on self and society. The answer sample echoes these concerns but further suggests that the acceptability of gene therapy varies depending on the specific application. Overall, the findings highlight the powerful role of social media as a rich resource for research into attitudes toward biomedicine and as a platform for knowledge exchange and public engagement for topics relating to health and disease.

Reliability of reservoir firm yield determined from the historical drought of record

USGS Publications Warehouse

Archfield, S.A.; Vogel, R.M.

2005-01-01

The firm yield of a reservoir is typically defined as the maximum yield that could have been delivered without failure during the historical drought of record. In the future, reservoirs will experience droughts that are either more or less severe than the historical drought of record. The question addressed here is what the reliability of such systems will be when operated at the firm yield. To address this question, we examine the reliability of 25 hypothetical reservoirs sited across five locations in the central and western United States. These locations provided a continuous 756-month streamflow record spanning the same time interval. The firm yield of each reservoir was estimated from the historical drought of record at each location. To determine the steady-state monthly reliability of each firm-yield estimate, 12,000-month synthetic records were generated using the moving-blocks bootstrap method. Bootstrapping was repeated 100 times for each reservoir to obtain an average steady-state monthly reliability R, the number of months the reservoir did not fail divided by the total months. Values of R were greater than 0.99 for 60 percent of the study reservoirs; the other 40 percent ranged from 0.95 to 0.98. Estimates of R were highly correlated with both the level of development (ratio of firm yield to average streamflow) and average lag-1 monthly autocorrelation. Together these two predictors explained 92 percent of the variability in R, with the level of development alone explaining 85 percent of the variability. Copyright ASCE 2005.

Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment

PubMed Central

Henderson, Gail E; Peay, Holly L; Kroon, Eugene; Cadigan, Rosemary Jean; Meagher, Karen; Jupimai, Thidarat; Gilbertson, Adam; Fisher, Jill; Ormsby, Nuchanart Q; Chomchey, Nitiya; Phanuphak, Nittaya; Ananworanich, Jintanat; Rennie, Stuart

2018-01-01

Though antiretroviral therapy is the standard of care for people living with HIV, its treatment limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early-phase cure trials, particularly those that include analytic treatment interruption (ATI), involve uncertain and potentially high risk, with minimal chance of clinical benefit. Some question whether such trials should be offered, given the risk/benefit imbalance, and whether those who choose to participate are acting rationally. We address these questions through a longitudinal decision-making study nested in a Thai acute HIV research cohort. In-depth interviews revealed central themes about decisions to join. Participants felt they possessed an important identity as members of the acute cohort, viewing their bodies as uniquely suited to both testing and potentially benefiting from HIV cure approaches. While acknowledging risks of ATI, most perceived they were given an opportunity to interrupt treatment, to test their own bodies and increase normalcy in a safe, highly monitored circumstance. They were motivated by potential benefits to themselves, the investigators and larger acute cohort, and others with HIV. They believed their own trial experiences and being able to give back to the community were sufficient to offset participation risks. These decisions were driven by the specific circumstances experienced by our participants. Judging risk/benefit ratios without appreciating these lived experiences can lead to false determinations of irrational decision- making. While this does not minimise vital oversight considerations about risk reduction and protection from harm, it argues for inclusion of a more participant-centered approach. PMID:29127137

Essays on Environmental Economics and Policy

NASA Astrophysics Data System (ADS)

Walker, W. Reed

A central feature of modern government is its role in designing welfare improving policies to address and correct market failures stemming from externalities and public goods. The rationale for most modern environmental regulations stems from the failure of markets to efficiently allocate goods and services. Yet, as with any policy, distributional effects are important there exist clear winners and losers. Despite the clear theoretical justification for environmental and energy policy, empirical work credibly identifying both the source and consequences of these externalities as well as the distributional effects of existing policies remains in its infancy. My dissertation focuses on the development of empirical methods to investigate the role of environmental and energy policy in addressing market failures as well as exploring the distributional implications of these policies. These questions are important not only as a justification for government intervention into markets but also for understanding how distributional consequences may shape the design and implementation of these policies. My dissertation investigates these questions in the context of programs and policies that are important in their own right. Chapters 1 and 2 of my dissertation explore the economic costs and distributional implications associated with the largest environmental regulatory program in the United States, the Clean Air Act. Chapters 3 and 4 examine the social costs of air pollution in the context of transportation externalities, showing how effective transportation policy has additional co-benefits in the form of environmental policy. My dissertation remains unified in both its subject matter and methodological approach -- using unique sources of data and sound research designs to understand important issues in environmental policy.

HOW PEOPLE RESPOND TO CONTINGENT VALUATION QUESTIONS

EPA Science Inventory

The purpose of the project is to understand better how individuals interpret and respond to contingent valuation (CV) questions. The research will address three issues: the reliability of the referendum questions format, the importance of reminding respondents about subst...

How Well Can Saliency Models Predict Fixation Selection in Scenes Beyond Central Bias? A New Approach to Model Evaluation Using Generalized Linear Mixed Models.

PubMed

Nuthmann, Antje; Einhäuser, Wolfgang; Schütz, Immo

2017-01-01

Since the turn of the millennium, a large number of computational models of visual salience have been put forward. How best to evaluate a given model's ability to predict where human observers fixate in images of real-world scenes remains an open research question. Assessing the role of spatial biases is a challenging issue; this is particularly true when we consider the tendency for high-salience items to appear in the image center, combined with a tendency to look straight ahead ("central bias"). This problem is further exacerbated in the context of model comparisons, because some-but not all-models implicitly or explicitly incorporate a center preference to improve performance. To address this and other issues, we propose to combine a-priori parcellation of scenes with generalized linear mixed models (GLMM), building upon previous work. With this method, we can explicitly model the central bias of fixation by including a central-bias predictor in the GLMM. A second predictor captures how well the saliency model predicts human fixations, above and beyond the central bias. By-subject and by-item random effects account for individual differences and differences across scene items, respectively. Moreover, we can directly assess whether a given saliency model performs significantly better than others. In this article, we describe the data processing steps required by our analysis approach. In addition, we demonstrate the GLMM analyses by evaluating the performance of different saliency models on a new eye-tracking corpus. To facilitate the application of our method, we make the open-source Python toolbox "GridFix" available.

Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes.

PubMed

Cedillo, Maribel; Libman, Ingrid M; Arena, Vincent C; Zhou, Lei; Trucco, Massimo; Ize-Ludlow, Diego; Pietropaolo, Massimo; Becker, Dorothy J

2015-01-01

The current increase in childhood type 1 diabetes (T1D) and obesity has led to two conflicting hypotheses and conflicting reports regarding the effects of overweight on initiation and spreading of islet cell autoimmunity vs earlier clinical manifestation of preexisting autoimmune β-cell damage driven by excess weight. The objective of the study was to address the question of whether the degree of β-cell autoimmunity and age are related to overweight at diabetes onset in a large cohort of T1D youth. This was a prospective cross-sectional study of youth with autoimmune T1D consecutively recruited at diabetes onset. The study was conducted at a regional academic pediatric diabetes center. Two hundred sixty-three consecutive children younger than 19 years at onset of T1D participated in the study. Relationships between body mass index and central obesity (waist circumference and waist to height ratio) and antigen spreading (islet cell autoantibody number), age, and cardiovascular (CVD) risk factors examined at onset and/or 3 months after the diagnosis were measured. There were no significant associations between number of autoantibodies with measures of adiposity. Age relationships revealed that a greater proportion of those with central obesity (21%) were in the youngest age group (0-4 y) compared with those without central obesity (6%) (P = .001). PATIENTS with central obesity had increased CVD risk factors and higher onset C-peptide levels (P < .05). No evidence was found to support the concept that obesity accelerates progression of autoantibody spreading once autoimmunity, marked by standard islet cell autoantibody assays, is present. Central obesity was present in almost one-third of the subjects and was associated with early CVD risk markers already at onset.

The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.

PubMed

Pang, Zhen; Wu, Nancy N; Zhao, Weiguang; Chain, David C; Schaffer, Erica; Zhang, Xin; Yamdagni, Preeti; Palejwala, Vaseem A; Fan, Chunpeng; Favara, Sarah G; Dressler, Holly M; Economides, Kyriakos D; Weinstock, Daniel; Cavallo, Jean S; Naimi, Souad; Galzin, Anne-Marie; Guillot, Etienne; Pruniaux, Marie-Pierre; Tocci, Michael J; Polites, H Greg

2011-10-01

Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the antiobesity effects of rimonabant, a CB1 antagonist, are mediated through the central or the peripheral CB1 receptors. To address this question, we generated transgenic mice with central nervous system (CNS)-specific knockdown (KD) of CB1, by expressing an artificial microRNA (AMIR) under the control of the neuronal Thy1.2 promoter. In the mutant mice, CB1 expression was reduced in the brain and spinal cord, whereas no change was observed in the superior cervical ganglia (SCG), sympathetic trunk, enteric nervous system, and pancreatic ganglia. In contrast to the neuronal tissues, CB1 was undetectable in the brown adipose tissue (BAT) or the liver. Consistent with the selective loss of central CB1, agonist-induced hypothermia was attenuated in the mutant mice, but the agonist-induced delay of gastrointestinal transit (GIT), a primarily peripheral nervous system-mediated effect, was not. Compared to wild-type (WT) littermates, the mutant mice displayed reduced body weight (BW), adiposity, and feeding efficiency, and when fed a high-fat diet (HFD), showed decreased plasma insulin, leptin, cholesterol, and triglyceride levels, and elevated adiponectin levels. Furthermore, the therapeutic effects of rimonabant on food intake (FI), BW, and serum parameters were markedly reduced and correlated with the degree of CB1 KD. Thus, KD of CB1 in the CNS recapitulates the metabolic phenotype of CB1 knockout (KO) mice and diminishes rimonabant's efficacy, indicating that blockade of central CB1 is required for rimonabant's antiobesity actions.

The Tale of Flooding over the Central United States: Not Bigger but More Frequent

NASA Astrophysics Data System (ADS)

Mallakpour, I.; Villarini, G.

2014-12-01

Flooding over the central United States is responsible for large societal and economic impacts, quantifiable in tens of fatalities and billions of dollars in damage. Because of these large repercussions, it is of paramount importance to examine whether the magnitude and/or frequency of flood events have been changing over the most recent decades. Here we address this research question using annual and seasonal maximum daily streamflow records from 774 U.S. Geological Survey (USGS) stations over the central United States (the study area includes North Dakota, South Dakota, Nebraska, Kansas, Missouri, Iowa, Minnesota, Wisconsin, Illinois, West Virginia, Kentucky, Ohio, Indiana, and Michigan). The focus is on "long" records (i.e., at least 50 years of data) ending no earlier than 2011. Analyses are performed using block-maximum and peak-over-threshold approaches. We find limited evidence suggesting increasing or decreasing trends in the magnitude of flood peaks over this area. On the other hand, there is much stronger evidence of increasing frequency of flood events. Therefore, our results support the notion that it is not so much that the largest flood peaks are getting larger, but rather that we have been experiencing a larger number of flood events every year. By examining the rainfall records, we are able to link these increasing trends to similar patterns in heavy rainfall over the region.

Sensory neuropathy may cause central neuronal reorganization but does not respecify perceptual quality or localization of sensation.

PubMed

Ginanneschi, Federica; Mondelli, Mauro; Rossi, Alessandro

2012-10-01

Functional reorganization in the somatosensory network after peripheral nerve lesions has been suspected to modify the clinical expression of symptoms. However, no conclusive evidence exists to support this notion. We addressed this question by investigating the topographic distribution of the subjective sensory report in various chronic human mononeuropathies. We report the clinical results of 86 patients who were diagnosed with meralgia paresthetica, 86 patients with ulnar neuropathy at the elbow, and 203 patients with carpal tunnel syndrome. In the carpal tunnel syndrome group, 10% of the patients exhibited a spread of sensory symptoms beyond the innervation territory of the median nerve. As previously reported, this spread was contingent upon an indirect compressive lesion of the ulnar nerve at the wrist. In all of the patients who were affected with meralgia paresthetica or ulnar neuropathy at the elbow, the peripheral referral of sensation was always within the anatomic distribution of the affected nerve. In human neuropathies, the projected sensory symptoms are restricted to the innervation territories of the affected nerves, with no extraterritorial spread. Thus, the somatosensory localization function remains accurate, despite the central reorganization that presumably occurs after nerve injury. We conclude that reorganization of the sensory connections within the central nervous system after peripheral nerve injury in humans is a clinically silent adaptive phenomenon.

Commentary on: "Clonal evolution of chemotherapy-resistant urothelial carcinoma." Faltas BM, Prandi D, Tagawa ST, Molina AM, Nanus DM, Sternberg C, Rosenberg J, Mosquera JM, Robinson B, Elemento O, Sboner A, Beltran H, Demichelis F, Rubin MA.: Nat Genet. 2016 Oct 17. http://dx.doi.org/10.1038/ng.3692.

PubMed

Lee, Byron H

2017-09-01

Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy. Our analysis provided several insights that are as follows: (1) chemotherapy-treated urothelial carcinoma is characterized by intrapatient mutational heterogeneity, and most mutations are not shared; (2) both branching evolution and metastatic spread are very early events in the natural history of urothelial carcinoma; (3) chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell-adhesion molecule and integrin signaling pathways; and (4) APOBEC-induced mutagenesis is clonally enriched in chemotherapy-treated urothelial carcinoma and continues to shape the evolution of urothelial carcinoma throughout its lifetime. Copyright © 2017 Elsevier Inc. All rights reserved.

Reconstructing Native American population history.

PubMed

Reich, David; Patterson, Nick; Campbell, Desmond; Tandon, Arti; Mazieres, Stéphane; Ray, Nicolas; Parra, Maria V; Rojas, Winston; Duque, Constanza; Mesa, Natalia; García, Luis F; Triana, Omar; Blair, Silvia; Maestre, Amanda; Dib, Juan C; Bravi, Claudio M; Bailliet, Graciela; Corach, Daniel; Hünemeier, Tábita; Bortolini, Maria Cátira; Salzano, Francisco M; Petzl-Erler, María Luiza; Acuña-Alonzo, Victor; Aguilar-Salinas, Carlos; Canizales-Quinteros, Samuel; Tusié-Luna, Teresa; Riba, Laura; Rodríguez-Cruz, Maricela; Lopez-Alarcón, Mardia; Coral-Vazquez, Ramón; Canto-Cetina, Thelma; Silva-Zolezzi, Irma; Fernandez-Lopez, Juan Carlos; Contreras, Alejandra V; Jimenez-Sanchez, Gerardo; Gómez-Vázquez, Maria José; Molina, Julio; Carracedo, Angel; Salas, Antonio; Gallo, Carla; Poletti, Giovanni; Witonsky, David B; Alkorta-Aranburu, Gorka; Sukernik, Rem I; Osipova, Ludmila; Fedorova, Sardana A; Vasquez, René; Villena, Mercedes; Moreau, Claudia; Barrantes, Ramiro; Pauls, David; Excoffier, Laurent; Bedoya, Gabriel; Rothhammer, Francisco; Dugoujon, Jean-Michel; Larrouy, Georges; Klitz, William; Labuda, Damian; Kidd, Judith; Kidd, Kenneth; Di Rienzo, Anna; Freimer, Nelson B; Price, Alkes L; Ruiz-Linares, Andrés

2012-08-16

The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call 'First American'. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.

The evolution of phenotypic integration: How directional selection reshapes covariation in mice.

PubMed

Penna, Anna; Melo, Diogo; Bernardi, Sandra; Oyarzabal, Maria Inés; Marroig, Gabriel

2017-10-01

Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex phenotypes, covariation plays an even more important role, as genetic associations between traits can bias and alter evolutionary change. Covariation can be shaped by complex interactions between loci, and this genetic architecture can also change during evolution. In this article, we analyzed mouse lines experimentally selected for changes in size to address the question of how multivariate covariation changes under directional selection, as well as to identify the consequences of these changes to evolution. Selected lines showed a clear restructuring of covariation in their cranium and, instead of depleting their size variation, these lines increased their magnitude of integration and the proportion of variation associated with the direction of selection. This result is compatible with recent theoretical works on the evolution of covariation that take the complexities of genetic architecture into account. This result also contradicts the traditional view of the effects of selection on available covariation and suggests a much more complex view of how populations respond to selection. © 2017 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Negotiating plausibility: intervening in the future of nanotechnology.

PubMed

Selin, Cynthia

2011-12-01

The national-level scenarios project NanoFutures focuses on the social, political, economic, and ethical implications of nanotechnology, and is initiated by the Center for Nanotechnology in Society at Arizona State University (CNS-ASU). The project involves novel methods for the development of plausible visions of nanotechnology-enabled futures, elucidates public preferences for various alternatives, and, using such preferences, helps refine future visions for research and outreach. In doing so, the NanoFutures project aims to address a central question: how to deliberate the social implications of an emergent technology whose outcomes are not known. The solution pursued by the NanoFutures project is twofold. First, NanoFutures limits speculation about the technology to plausible visions. This ambition introduces a host of concerns about the limits of prediction, the nature of plausibility, and how to establish plausibility. Second, it subjects these visions to democratic assessment by a range of stakeholders, thus raising methodological questions as to who are relevant stakeholders and how to activate different communities so as to engage the far future. This article makes the dilemmas posed by decisions about such methodological issues transparent and therefore articulates the role of plausibility in anticipatory governance.

Trust and Its Role in the Medical Encounter.

PubMed

Holland, Stephen; Stocks, David

2017-09-01

This paper addresses two research questions. The first is theoretical: What is trust? In the first half of this paper we present a distinctive tripartite analysis. We describe three attitudes, here called reliance, specific trust and general trust, each of which is characterised and illustrated. We argue that these attitudes are related, but not reducible, to one another. We suggest that the current impasse in the analysis of trust is in part due to the fact that some writers allude to these distinctions, but unclearly so, whilst others elide them altogether. The second research question focuses on doctor-patient interaction. Trust is often said to be central in medical encounters but this strikes us as too vague. The success of doctor-patient relations in part depends on adopting the most appropriate of the three attitudes we delineate. We argue that reliance is the appropriate attitude for most medical encounters. When circumstances do require trust, the distinction between specific trust and general trust is crucial. We describe medical encounters requiring specific trust. General trust is less often required in medicine; but it is appropriate in some cases and, when called for, it is called for strongly.

[Assessment of health-related quality of life with the German SF-8. A comparison of telephone and postal survey modes].

PubMed

Erhart, M; Wetzel, R; Krügel, A; Ravens-Sieberer, U

2005-12-01

Within a comprehensive comparison of telephone and postal survey methods the SF-8 was applied to assess adult's health-related quality of life. The 1690 subjects were randomly assigned to a telephone survey and a postal survey. Comparisons across the different modes of administration addressed the response rates, central tendency, deviation, ceiling and floor effects observed in the SF-8 scores as well as the inter-item correlation. The importance of age and gender as moderating factors was investigated. Results indicate no or small statistically significant differences in the responses to the SF-8 depending on the actual mode of administration and the health aspect questioned. It was concluded that further investigations should focus on the exact nature of these deviations and try to generate correction factors.

Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health.

PubMed

Leulier, François; MacNeil, Lesley T; Lee, Won-Jae; Rawls, John F; Cani, Patrice D; Schwarzer, Martin; Zhao, Liping; Simpson, Stephen J

2017-03-07

Nutrition is paramount in shaping all aspects of animal biology. In addition, the influence of the intestinal microbiota on physiology is now widely recognized. Given that diet also shapes the intestinal microbiota, this raises the question of how the nutritional environment and microbial assemblages together influence animal physiology. This research field constitutes a new frontier in the field of organismal biology that needs to be addressed. Here we review recent studies using animal models and humans and propose an integrative framework within which to define the study of the diet-physiology-microbiota systems and ultimately link it to human health. Nutritional Geometry sits centrally in the proposed framework and offers means to define diet compositions that are optimal for individuals and populations. Copyright © 2017 Elsevier Inc. All rights reserved.

Evolutionary rescue: linking theory for conservation and medicine.

PubMed

Alexander, Helen K; Martin, Guillaume; Martin, Oliver Y; Bonhoeffer, Sebastian

2014-12-01

Evolutionary responses that rescue populations from extinction when drastic environmental changes occur can be friend or foe. The field of conservation biology is concerned with the survival of species in deteriorating global habitats. In medicine, in contrast, infected patients are treated with chemotherapeutic interventions, but drug resistance can compromise eradication of pathogens. These contrasting biological systems and goals have created two quite separate research communities, despite addressing the same central question of whether populations will decline to extinction or be rescued through evolution. We argue that closer integration of the two fields, especially of theoretical understanding, would yield new insights and accelerate progress on these applied problems. Here, we overview and link mathematical modelling approaches in these fields, suggest specific areas with potential for fruitful exchange, and discuss common ideas and issues for empirical testing and prediction.

High-Mass Stars in the Centers of Young Dense Clusters: Mass Segregation, Binary Mergers and Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Zinnecker, H.

We start by discussing dense, young star-clusters, particularly the 30 Doradus cluster with its core R136. The question of mass segregation and core collapse of the massive stars is addressed. Analytical estimates of relaxation times and collision times predict that the central N=10 subsystem of massive stars in the R136 core will evolve dynamically in such a way and fast enough (i.e. within their main-sequence lifetime of a few Myr) that a dominant massive binary system is formed whose orbit will shrink to a point where merging of the components appears inevitable. The merger product will be spinning rapidly, and we put forward the idea that this rare and very massive object might be the perfect precursor of a gamma-ray burst (collapsar).

Behavioral assessment of adaptive feedback equalization in a digital hearing aid.

PubMed

French-St George, M; Wood, D J; Engebretson, A M

1993-01-01

An evaluation was made of the efficacy of a digital feedback equalization algorithm employed by the Central Institute for the Deaf Wearable Adaptive Digital Hearing Aid. Three questions were addressed: 1) Does acoustic feedback limit gain adjustments made by hearing aid users? 2) Does feedback equalization permit users with hearing-impairment to select more gain without feedback? and, 3) If more gain is used when feedback equalization is active, does word identification performance improve? Nine subjects with hearing impairment participated in the study. Results suggest that listeners with hearing impairment are indeed limited by acoustic feedback when listening to soft speech (55 dB A) in quiet. The average listener used an additional 4 dB gain when feedback equalization was active. This additional gain resulted in an average 10 rationalized arcsine units (RAU) improvement in word identification score.

Coupled Ethical-Epistemic Analysis of Climate Change

NASA Astrophysics Data System (ADS)

Vezer, M.

2015-12-01

Are there inherent limitations to what we can know about how the climate will change in the years ahead? How can we use what is known about the future climate in a way that promotes ethical decision-making? These questions call for urgent attention because important policy decisions need to be made in order to prepare for climate change in North America and around the world. While the science of climate change is central to this line of inquiry, the fields of epistemology, moral, political and environmental philosophy may provide insights on how these issues should be addressed. Detailing the relationship between evidential and ethical dimensions of climate change, this research aims to improve our understanding of the interconnections among several lines of inquiry and to develop solutions to problems of decision-making under conditions of scientific uncertainty.

Health care education for dialogue and dialogic relationships.

PubMed

Glen, S

1999-01-01

This article will address the question: how can health care education best take seriously the task of educating for professional practice within a post-traditional, liberal democratic society? In the setting of modernity, the altered personal and professional self has to be explored and constructed as part of a reflective process of connecting personal and professional change: in essence, to develop self-knowledge. A moral life, or 'working morality', that evolves out of a process of ongoing dialogue and conversation is required. What is advocated here is a more social model of health care education that acknowledges a social or communal dimension to knowledge and the centrality of relationships for the full development of the individual personally and professionally, fosters our capacity to identify who we are both personally and professionally, connects reason and dialogue, and educates for dialogue and dialogic relationships.

Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop.

PubMed

Sali, Andrej; Berman, Helen M; Schwede, Torsten; Trewhella, Jill; Kleywegt, Gerard; Burley, Stephen K; Markley, John; Nakamura, Haruki; Adams, Paul; Bonvin, Alexandre M J J; Chiu, Wah; Peraro, Matteo Dal; Di Maio, Frank; Ferrin, Thomas E; Grünewald, Kay; Gutmanas, Aleksandras; Henderson, Richard; Hummer, Gerhard; Iwasaki, Kenji; Johnson, Graham; Lawson, Catherine L; Meiler, Jens; Marti-Renom, Marc A; Montelione, Gaetano T; Nilges, Michael; Nussinov, Ruth; Patwardhan, Ardan; Rappsilber, Juri; Read, Randy J; Saibil, Helen; Schröder, Gunnar F; Schwieters, Charles D; Seidel, Claus A M; Svergun, Dmitri; Topf, Maya; Ulrich, Eldon L; Velankar, Sameer; Westbrook, John D

2015-07-07

Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the first wwPDB Hybrid/Integrative Methods Task Force Workshop held at the European Bioinformatics Institute in Hinxton, UK, on October 6 and 7, 2014. At the workshop, experts in various experimental fields of structural biology, experts in integrative modeling and visualization, and experts in data archiving addressed a series of questions central to the future of structural biology. How should integrative models be represented? How should the data and integrative models be validated? What data should be archived? How should the data and models be archived? What information should accompany the publication of integrative models? Copyright © 2015 Elsevier Ltd. All rights reserved.

Reply to comment by Tan et al. on "Sandbox modeling of evolving thrust wedges with different preexisting topographic relief: Implications for the Longmen Shan thrust belt, eastern Tibet"

NASA Astrophysics Data System (ADS)

Sun, Chuang; Jia, Dong; Yin, Hongwei; Chen, Zhuxin; Li, Zhigang; Li, Shen; Wei, Dongtao; Li, Yiquan; Yan, Bin; Wang, Maomao; Fang, Shaozhi; Cui, Jian

2017-02-01

Tan et al. comment that the preexisting topographic relief in our sandbox is opposed to its prototype in the central Longmen Shan. Therefore, the comparison between our sandbox modeling and the natural topography is questionable and does not agree with our conclusion that the Xiaoyudong fault is a tear fault. First, we are grateful to the authors for their approval of our sandbox modeling and its contribution to understanding fault behavior within thrust wedges. However, after reading the comment carefully, we found that they misunderstood the meaning of topographic relief we conveyed. In response, we would like to address the differences between the topography in their comment and the orogen-scale topography we investigated in our modeling to defend our conclusion.

From dirt to industrial applications: Pseudomonas putida as a Synthetic Biology chassis for hosting harsh biochemical reactions.

PubMed

Nikel, Pablo I; Chavarría, Max; Danchin, Antoine; de Lorenzo, Víctor

2016-10-01

The soil bacterium Pseudomonas putida is endowed with a central carbon metabolic network capable of fulfilling high demands of reducing power. This situation arises from a unique metabolic architecture that encompasses the partial recycling of triose phosphates to hexose phosphates-the so-called EDEMP cycle. In this article, the value of P. putida as a bacterial chassis of choice for contemporary, industrially-oriented metabolic engineering is addressed. The biochemical properties that make this bacterium adequate for hosting biotransformations involving redox reactions as well as toxic compounds and intermediates are discussed. Finally, novel developments and open questions in the continuous quest for an optimal microbial cell factory are presented at the light of current and future needs in the area of biocatalysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Endangered species and a threatened discipline: behavioural ecology.

PubMed

Caro, Tim; Sherman, Paul W

2011-03-01

Behavioural ecologists often see little connection between the current conservation crisis and the future of their discipline. This view is myopic because our abilities to investigate and interpret the adaptive significance and evolutionary histories of behaviours are increasingly being compromised in human-dominated landscapes because of species extinctions, habitat destruction, invasive species, pollution, and climate change. In this review, we argue that many central issues in behavioural ecology will soon become prohibitively difficult to investigate and interpret, thus impeding the rapid progress that characterizes the field. To address these challenges, behavioural ecologists should design studies not only to answer basic scientific questions but also to provide ancillary information for protection and management of their study organisms and habitats, and then share their biological insights with the applied conservation community. Copyright © 2010 Elsevier Ltd. All rights reserved.

Heat-assisted magnetic recording of bit-patterned media beyond 10 Tb/in2

NASA Astrophysics Data System (ADS)

Vogler, Christoph; Abert, Claas; Bruckner, Florian; Suess, Dieter; Praetorius, Dirk

2016-03-01

The limits of areal storage density that is achievable with heat-assisted magnetic recording are unknown. We addressed this central question and investigated the areal density of bit-patterned media. We analyzed the detailed switching behavior of a recording bit under various external conditions, allowing us to compute the bit error rate of a write process (shingled and conventional) for various grain spacings, write head positions, and write temperatures. Hence, we were able to optimize the areal density yielding values beyond 10 Tb/in2. Our model is based on the Landau-Lifshitz-Bloch equation and uses hard magnetic recording grains with a 5-nm diameter and 10-nm height. It assumes a realistic distribution of the Curie temperature of the underlying material, grain size, as well as grain and head position.

An updated climatology of explosive cyclones using alternative measures of cyclone intensity

NASA Astrophysics Data System (ADS)

Hanley, J.; Caballero, R.

2009-04-01

Using a novel cyclone tracking and identification method, we compute a climatology of explosively intensifying cyclones or ‘bombs' using the ERA-40 and ERA-Interim datasets. Traditionally, ‘bombs' have been identified using a central pressure deepening rate criterion (Sanders and Gyakum, 1980). We investigate alternative methods of capturing such extreme cyclones. These methods include using the maximum wind contained within the cyclone, and using a potential vorticity column measure within such systems, as a measure of intensity. Using the different measures of cyclone intensity, we construct and intercompare maps of peak cyclone intensity. We also compute peak intensity probability distributions, and assess the evidence for the bi-modal distribution found by Roebber (1984). Finally, we address the question of the relationship between storm intensification rate and storm destructiveness: are ‘bombs' the most destructive storms?

SHRIMP-RG U-Pb isotopic systematics of zircon from the Angel Lake orthogneiss, East Humboldt Range, Nevada: is this really Archean crust? REPLY

USGS Publications Warehouse

Premo, Wayne R.

2010-01-01

The comments from McGrew and Snoke are well received and their concerns for the interpretations in our paper (Premo et al., 2008), which questions the original contention that the Angel Lake orthogneiss is an Archean rock, are many and varied—all of which we will attempt to address. As they point out, this issue is an important one as this particular crustal exposure may delimit the southwestern extent of the Archean Wyoming province (Foster et al., 2006; Mueller and Frost, 2006), which has implications for the true crustal evolution of this region of the Great Basin and perhaps more importantly its relationship (if any) to the location of the world-class gold deposits of north-central Nevada (e.g., Howard, 2003).

Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative.

PubMed

Dick, Andrew D; Rosenbaum, James T; Al-Dhibi, Hassan A; Belfort, Rubens; Brézin, Antoine P; Chee, Soon Phaik; Davis, Janet L; Ramanan, Athimalaipet V; Sonoda, Koh-Hei; Carreño, Ester; Nascimento, Heloisa; Salah, Sawsen; Salek, Sherveen; Siak, Jay; Steeples, Laura

2018-05-01

An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

NASA's Solar System Exploration Research Virtual Institute: Merging Science and Exploration

NASA Astrophysics Data System (ADS)

Pendleton, Yvonne J.

2016-10-01

Established in 2013, through joint funding from the NASA Science Mission Directorate (SMD) and Human Exploration and Operations Mission Directorate (HEOMD), NASA's Solar System Exploration Research Virtual Institute (SSERVI) is focused on science at the intersection of these two enterprises. Addressing questions of value to the human exploration program that also represent important research relevant to planetary science, SSERVI creates a bridge between HEOMD and SMD. The virtual institute model reduces travel costs, but its primary virtue is the ability to join together colleagues who bring the right expertise, techniques and tools, regardless of their physical location, to address multi-faceted problems, at a deeper level than could be achieved through the typical period of smaller research grants. In addition, collaboration across team lines and international borders fosters the creation of new knowledge, especially at the intersections of disciplines that might not otherwise overlap.SSERVI teams investigate the Moon, Near-Earth Asteroids, and the moons of Mars, addressing questions fundamental to these target bodies and their near space environments. The institute is currently composed of nine U.S. teams of 30-50 members each, distributed geographically across the United States, ten international partners, and a Central Office located at NASA Ames Research Center in Silicon Valley, CA. U.S. teams are competitively selected through peer-reviewed proposals submitted to NASA every 2-3 years, in response to a Cooperative Agreement Notice (CAN). The current teams were selected under CAN-1, with funding for five years (2014-2019). A smaller, overlapping set of teams are expected to be added in 2017 in response to CAN-2, thereby providing continuity and a firm foundation for any directional changes NASA requires as the CAN-1 teams end their term. This poster describes the research areas and composition of the institute to introduce SSERVI to the broader planetary science community and to researchers who want to participate in future opportunities.

Preventing and Addressing Challenging Behavior: Common Questions and Practical Strategies

ERIC Educational Resources Information Center

Hemmeter, Mary Louise; Ostrosky, Michaelene M.; Corso, Robert M.

2012-01-01

The purpose of this article is to offer preschool teachers strategies for preventing challenging behavior and supporting the development of social skills and emotional competencies. This article is framed in a question and answer format using questions from teachers who the authors have worked with in the past. These questions and strategies are…

Evaluating the Quality of a Chat Service

ERIC Educational Resources Information Center

Arnold, Julie; Kaske, Neal K.

2005-01-01

A quantitative study of a university chat reference service (online synchronous) addresses the following research questions: (1) What types of questions are being asked? (2) Who is asking the questions of the service? and (3) Did the customers get correct answers to their questions? All the transcripts (351) from January through August 2002 were…

Some Tough Questions about Community Colleges. AACJC Pocket Reader, 3.

ERIC Educational Resources Information Center

Parnell, Dale

Using a question-and-answer format, this booklet addresses eleven of the most frequently posed questions about community, technical, and junior colleges and attempts to allay misunderstandings about the nature and role of these institutions. The questions cover the distinctions between the different types of 2-year college; their history and…

Using Notable Children's Literature and Questioning Techniques to Enhance Comprehension.

ERIC Educational Resources Information Center

Poole, Gary; Poole, Scott

Intended for language arts teachers of the upper elementary grades, this guide suggests vocabulary and discussion questions for teaching novels. The questions are on an inferential level of interpretation, rather than literal, and address such topics as style, technique, and plot development. Novels for which questions are provided are: (1)…

Implementing Response to Intervention: Practices and Perspectives from Five Schools--Frequently Asked Questions

ERIC Educational Resources Information Center

Tackett, Kathryn Klingler; Roberts, Greg; Baker, Scott; Scammacca, Nancy

2009-01-01

One question frequently arises in the work of the Regional Comprehensive Centers: "What are states, districts, and schools doing about RTI?" This document addresses that question, with particular focus on instruction and the implementation of effective practices. It uses a frequently asked questions (FAQs) format, with answers based on…

Volcanic rocks and the geologic history of Mars

NASA Technical Reports Server (NTRS)

Salpas, P. A.

1988-01-01

A number of questions exist regarding the geology of Mars which can be addressed by the proposed Mars rover-sample return mission. The use of a rover during the proposed mission greatly enhances the ability to investigate multiple aspects of Martian geology and geological history. Attempting to address all of the important questions may dilute the amount of information that can be obtained regarding each question and may result in no satisfactory answers. Prioritization is essential to a successful mission. The task of setting priorities is simplified somewhat when it is considered that answers to some of these questions do not require taking samples, and that for some questions, sample location is not as important as for others. The surface of Mars presents two distinct terrains, both of which have the potential to contain valuable information regarding the composition of Mars.

Question Generation via Overgenerating Transformations and Ranking

DTIC Science & Technology

2009-01-01

School of Computer Science Carnegie Mellon University 5000 Forbes Ave., Pittsburgh, PA 15213 www.lti.cs.cmu.edu c©2009, Michael Heilman and Noah A...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Carnegie Mellon University ,School of Computer Science,5000 Forbes Ave,Pittsburgh,PA,15213 8...1967), in particular those that view a question as a transformation of a canonical declarative sentence ( Chomsky , 1973). In computational linguistics

The New ADL Registry. ADL Registry Web Portal Changes

DTIC Science & Technology

2009-08-19

Questions or Comments? Jason Haag Learning Technology Analyst jason.haag.ctr@adlnet.gov +1.850.471.1300 ...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Advanced Decision Learning (ADL),Joint ADL Co-Lab,13501 Ingenuity Drive Suite 248,Orlando,FL,32826 8... Technologies /adlr/  News and Announcements  Frequently Asked Questions (FAQ)  Documentation  Events and Event Registration 4 ADL Registry Functional

Common reasons why acne patients call the office.

PubMed

Barnes, Lauren E; Al-Dabagh, Amir; Huang, William W; Feldman, Steven R

2014-05-16

Communication between physicians and patients is essential to providing proper medical care. At times, patients leave visits with insufficiently addressed questions. These questions prompt patients to call the clinic for additional information, which disrupts the flow of care, delays proper treatment, and reduces patient satisfaction. We aim to examine acne patients' post-visit questions to develop interventions to improve patient education and reduce call backs. A retrospective electronic medical record chart review was performed involving Wake Forest Baptist Health Dermatology clinic visits between October 1, 2012 and October 31, 2012. We identified acne patients using clinic visit notes and recorded their telephone calls to the clinic between October 1, 2012 and March 29, 2013. Of 315 acne patients, 31 (9.8%) called the clinic. Isotretinoin was the subject of 66.7% of the calls, half of which involved questions about potential side effects. Other calls addressed topical medications, acne symptoms, and pharmacy requests. The study involved one center and email and fax correspondence was not captured. We found gaps in communication sufficient to require patients to call in for support, specifically regarding oral isotretinoin treatment. Interventions to address these questions have the potential to improve quality of care.

Conscience in Childhood: Old Questions, New Answers

ERIC Educational Resources Information Center

Aksan, Nazan; Kochanska, Grazyna

2005-01-01

Although conscience has been the focus of reflection for centuries, fundamental questions regarding its organization have not been fully answered. To address those questions, the authors applied structural equation modeling techniques to longitudinal data comprising multiple behavioral measures of children's conscience, obtained in parallel…

Speech and nonspeech: What are we talking about?

PubMed

Maas, Edwin

2017-08-01

Understanding of the behavioural, cognitive and neural underpinnings of speech production is of interest theoretically, and is important for understanding disorders of speech production and how to assess and treat such disorders in the clinic. This paper addresses two claims about the neuromotor control of speech production: (1) speech is subserved by a distinct, specialised motor control system and (2) speech is holistic and cannot be decomposed into smaller primitives. Both claims have gained traction in recent literature, and are central to a task-dependent model of speech motor control. The purpose of this paper is to stimulate thinking about speech production, its disorders and the clinical implications of these claims. The paper poses several conceptual and empirical challenges for these claims - including the critical importance of defining speech. The emerging conclusion is that a task-dependent model is called into question as its two central claims are founded on ill-defined and inconsistently applied concepts. The paper concludes with discussion of methodological and clinical implications, including the potential utility of diadochokinetic (DDK) tasks in assessment of motor speech disorders and the contraindication of nonspeech oral motor exercises to improve speech function.

Irregular migration and informal economy in Southern and Central-Eastern Europe: breaking the vicious cycle?

PubMed

Maroukis, Thanos; Iglicka, Krystyna; Gmaj, Katarzyna

2011-01-01

The flexible and cheap labour that European “post-industrial” economies are in need of is often facilitated by undeclared labour. The undocumented migrant, from his/her part, relatively easily finds work that suits his -- at least initial -- plans. What lies behind this nexus between irregular migration and informal economy? To what extent can this nexus be attributed to the structural features of the so-called “secondary”, as opposed to “primary”, labour market? And how does migration policy correlate with this economic context and lead to the entrapment of migrants in irregularity? Finally, can this vicious cycle of interests and life-strategies be broken and what does the experience of the migrants indicate in this respect? This paper addresses these questions via an exploration of the grounds upon which irregular migration and the shadow economy complement each other in southern Europe (SE) and central and Eastern Europe (CEE) (two regions at different points in the migration cycle). In doing so, the dynamic character of the nexus between informal economy and irregular migration will come to the fore, and the abstract identity of the “average” undocumented migrant will be deconstructed.

Modelling the evolution of a bi-partite network Peer referral in interlocking directorates*

PubMed Central

Edling, Christofer

2010-01-01

A central part of relational ties between social actors are constituted by shared affiliations and events. The action of joint participation reinforces personal ties between social actors as well as mutually shared values and norms that in turn perpetuate the patterns of social action that define groups. Therefore the study of bipartite networks is central to social science. Furthermore, the dynamics of these processes suggests that bipartite networks should not be considered static structures but rather be studied over time. In order to model the evolution of bipartite networks empirically we introduce a class of models and a Bayesian inference scheme that extends previous stochastic actor-oriented models for unimodal graphs. Contemporary research on interlocking directorates provides an area of research in which it seems reasonable to apply the model. Specifically, we address the question of how tie formation, i.e. director recruitment, contributes to the structural properties of the interlocking directorate network. For boards of directors on the Stockholm stock exchange we propose that a prolific mechanism in tie formation is that of peer referral. The results indicate that such a mechanism is present, generating multiple interlocks between boards. PMID:24944435

Data Sharing in Astrobiology: The Astrobiology Habitable Environments Database (AHED)

NASA Technical Reports Server (NTRS)

Lafuente, B.; Bristow, T.; Stone, N.; Pires, A.; Keller, R.; Downs, Robert; Blake, D.; Fonda, M.

2017-01-01

Astrobiology is a multidisciplinary area of scientific research focused on studying the origins of life on Earth and the conditions under which life might have emerged elsewhere in the universe. NASA uses the results of Astrobiology research to help define targets for future missions that are searching for life elsewhere in the universe. The understanding of complex questions in Astrobiology requires integration and analysis of data spanning a range of disciplines including biology, chemistry, geology, astronomy and planetary science. However, the lack of a centralized repository makes it difficult for Astrobiology teams to share data and benefit from resultant synergies. Moreover, in recent years, federal agencies are requiring that results of any federally funded scientific research must be available and useful for the public and the science community. The Astrobiology Habitable Environments Database (AHED), developed with a consolidated group of astrobiologists from different active research teams at NASA Ames Research Center, is designed to help to address these issues. AHED is a central, high-quality, long-term data repository for mineralogical, textural, morphological, inorganic and organic chemical, isotopic and other information pertinent to the advancement of the field of Astrobiology.

Data Sharing in Astrobiology: the Astrobiology Habitable Environments Database (AHED)

NASA Technical Reports Server (NTRS)

Lafuente, B.; Bristow, T.; Stone, N.; Pires, A.; Keller, R. M.; Downs, R. T.; Blake, D.; Fonda, M.

2017-01-01

Astrobiology is a multidisciplinary area of scientific research focused on studying the origins of life on Earth and the conditions under which life might have emerged elsewhere in the universe. NASA uses the results of Astrobiology research to help define targets for future missions that are searching for life elsewhere in the universe. The understanding of complex questions in Astrobiology requires integration and analysis of data spanning a range of disciplines including biology, chemistry, geology, astronomy and planetary science. However, the lack of a centralized repository makes it difficult for Astrobiology teams to share data and benefit from resultant synergies. Moreover, in recent years, federal agencies are requiring that results of any federally funded scientific research must be available and useful for the public and the science community. The Astrobiology Habitable Environments Database (AHED), developed with a consolidated group of astrobiologists from different active research teams at NASA Ames Research Center, is designed to help to address these issues. AHED is a central, high-quality, long-term data repository for mineralogical, textural, morphological, inorganic and organic chemical, isotopic and other information pertinent to the advancement of the field of Astrobiology.

Requirements for color technology

NASA Astrophysics Data System (ADS)

Campbell, Ronald B., Jr.

1993-06-01

The requirements for color technology in the general office are reviewed. The two most salient factors driving the requirements for color are the information explosion and the virtually negligible growth in white collar productivity in the recent past. Accordingly, the business requirement upon color technology is that it be utilized in an effective and efficient manner to increase office productivity. Recent research on productivity and growth has moved beyond the classical two factor productivity model of labor and capital to explicitly include knowledge as a third and vital factor. Documents are agents of knowledge in the general office. Documents articulate, express, disseminate, and communicate knowledge. The central question addressed here is how can color, in conjunction with other techniques such as graphics and document design, improve the growth of knowledge? The central thesis is that the effective use of color to convert information into knowledge is one of the most powerful ways to increase office productivity. Material on the value of color is reviewed. This material is related to the role of documents. Document services are the way in which users access and utilize color technology. The requirements for color technology are then defined against the services taxonomy.

Genetics of reproduction and regulation of honeybee (Apis mellifera L.) social behavior.

PubMed

Page, Robert E; Rueppell, Olav; Amdam, Gro V

2012-01-01

Honeybees form complex societies with a division of labor for reproduction, nutrition, nest construction and maintenance, and defense. How does it evolve? Tasks performed by worker honeybees are distributed in time and space. There is no central control over behavior and there is no central genome on which selection can act and effect adaptive change. For 22 years, we have been addressing these questions by selecting on a single social trait associated with nutrition: the amount of surplus pollen (a source of protein) that is stored in the combs of the nest. Forty-two generations of selection have revealed changes at biological levels extending from the society down to the level of the gene. We show how we constructed this vertical understanding of social evolution using behavioral and anatomical analyses, physiology, genetic mapping, and gene knockdowns. We map out the phenotypic and genetic architectures of food storage and foraging behavior and show how they are linked through broad epistasis and pleiotropy affecting a reproductive regulatory network that influences foraging behavior. This is remarkable because worker honeybees have reduced reproductive organs and are normally sterile; however, the reproductive regulatory network has been co-opted for behavioral division of labor.

The epistemic and aleatory uncertainties of the ETAS-type models: an application to the Central Italy seismicity.

PubMed

Lombardi, A M

2017-09-18

Stochastic models provide quantitative evaluations about the occurrence of earthquakes. A basic component of this type of models are the uncertainties in defining main features of an intrinsically random process. Even if, at a very basic level, any attempting to distinguish between types of uncertainty is questionable, an usual way to deal with this topic is to separate epistemic uncertainty, due to lack of knowledge, from aleatory variability, due to randomness. In the present study this problem is addressed in the narrow context of short-term modeling of earthquakes and, specifically, of ETAS modeling. By mean of an application of a specific version of the ETAS model to seismicity of Central Italy, recently struck by a sequence with a main event of Mw6.5, the aleatory and epistemic (parametric) uncertainty are separated and quantified. The main result of the paper is that the parametric uncertainty of the ETAS-type model, adopted here, is much lower than the aleatory variability in the process. This result points out two main aspects: an analyst has good chances to set the ETAS-type models, but he may retrospectively describe and forecast the earthquake occurrences with still limited precision and accuracy.

Public discourse on mental health and psychiatry: Representations in Swedish newspapers.

PubMed

Ohlsson, Robert

2018-05-01

Mass media plays a central role in shaping public discourse on health and illness. In order to examine media representations of mental health and expert knowledge in this field, two major Swedish daily newspapers from the year 2009 were qualitatively analysed. Drawing on the theory of social representations, the analysis focused on how issues concerning mental health and different perspectives are represented. The results show how the concept of mental illness is used in different and often taken-for-granted ways and how the distinction between normal and pathological is a central underlying question. Laypersons' perspectives are supplemented by views of professionals in the newspapers, where signs of confidence and dependence on expert knowledge are juxtaposed with critique and expressions of distrust. The newspaper discourse thus has salient argumentative features and the way that conflicts are made explicit and issues concerning authoritative knowledge are addressed indicates ambivalence towards the authoritative role of expert knowledge concerning mental health. In this way, the newspapers provide a complex epistemic context for everyday sense-making that can be assumed to have implications for relations between laypersons and professionals in the field of mental health.

Using science and psychology to improve the dissemination and evaluation of scientific work.

PubMed

Buttliere, Brett T

2014-01-01

Here I outline some of what science can tell us about the problems in psychological publishing and how to best address those problems. First, the motivation behind questionable research practices is examined (the desire to get ahead or, at least, not fall behind). Next, behavior modification strategies are discussed, pointing out that reward works better than punishment. Humans are utility seekers and the implementation of current change initiatives is hindered by high initial buy-in costs and insufficient expected utility. Open science tools interested in improving science should team up, to increase utility while lowering the cost and risk associated with engagement. The best way to realign individual and group motives will probably be to create one, centralized, easy to use, platform, with a profile, a feed of targeted science stories based upon previous system interaction, a sophisticated (public) discussion section, and impact metrics which use the associated data. These measures encourage high quality review and other prosocial activities while inhibiting self-serving behavior. Some advantages of centrally digitizing communications are outlined, including ways the data could be used to improve the peer review process. Most generally, it seems that decisions about change design and implementation should be theory and data driven.

The Art of Questions: Inquiry, the CCSS, and School Librarians

ERIC Educational Resources Information Center

Wadham, Rachel

2013-01-01

This article examines the association among inquiry, the Common Core State Standards (CCSS) and school librarians. It explains the significance of asking questions, and describes the characteristics of the questions that are central to inquiry learning. The role of school librarians in inquiry learning and the implementation of CCSS is also…

Educational Research and Policy: Epistemological Considerations

ERIC Educational Resources Information Center

Bridges, David; Watts, Michael

2008-01-01

This article is centrally concerned with the sort of knowledge that can and should inform educational policy--and it treats this as an epistemological question. It distinguishes this question from the more extensively explored question of what sort of knowledge in what form policy-makers do in fact commonly take into account. The article examines…

Exploring experiences of Personal Support Worker education in Ontario, Canada.

PubMed

Kelly, Christine

2017-07-01

There is growing attention to the training and education of Personal Support Workers, or PSWs, who work in community, home and long-term care settings supporting older people and people with disabilities. In Ontario, Canada, amid a volatile policy landscape, the provincial government launched an effort to standardise PSW education. Using qualitative methods, this study considered the question: What are the central educational issues reflected by students, working PSWs and key informants, and are they addressed by the PSW programme and training standards? Phase one was a public domain analysis completed between January and March 2014 and updated for major developments after that period. Phase two, completed between August 2014 and March 2015, included 15 key informant interviews and focus group discussions and mini-phone interviews with 35 working PSWs and current PSW students. According to the participants, the central educational issues are: casualisation of labour that is not conveyed in educational recruitment efforts, disconnect between theory and working conditions, overemphasis on long-term care as a career path, and variability of PSW education options. While the standards should help to address the final issue, they do not address the other key issues raised, which have to do with the structural organisation of work. There is thus a disconnect between the experiences of students, PSWs and key informants and the policy decisions surrounding this sector. This is particularly significant as education is often touted as a panacea for issues in long-term and community care. In fact, the curriculum of some of the PSW programmes, especially those in public college settings, is robust. Yet, the underlying issues will remain barring a structural overhaul of the organisation of long-term and community care sectors founded on a social revaluing of older people and the gendered work of care. © 2017 John Wiley & Sons Ltd.

Periodontal disease awareness among pregnant women in the central and eastern regions of Saudi Arabia.

PubMed

Asa'ad, Farah A; Rahman, Ghousia; Al Mahmoud, Noura; Al Shamasi, Ebtehaj; Al Khuwaileidi, Abrar

2015-02-01

The purpose of this study was to assess the knowledge and awareness regarding periodontal disease and its effects on pregnancy among pregnant women in the central and eastern regions of Saudi Arabia. In this cross-sectional survey, self-administered, structured questionnaires were distributed to 300 pregnant women who were chosen randomly from attendees of maternity health care centers in the central and eastern regions of Saudi Arabia. The questions were developed from literature reviews of articles. The questionnaire addressed personal and sociodemographic variables, periodontal health awareness, and knowledge of pregnant women. The questionnaire was translated into Arabic and was pretested during the pilot study on a random sample of 50 pregnant women. Data were analyzed by χ(2) -tests, with the level of significance set at P < 0.05. An overall response rate of 81% was obtained. Approximately 53% had a higher level of education, but only 21% knew how to define dental plaque and 30% knew its harmful effects. Almost 73% stated that gum disease could be prevented through toothbrushing and flossing. Approximately 97% of the respondents knew the negative effect of smoking, while only 12% knew there was a possible relationship between periodontal disease and adverse pregnancy outcomes. The results of this cross-sectional study found that there is limited knowledge and awareness about periodontal disease and its possible effects on pregnancy among pregnant women attending maternal health care centers in the central and eastern regions of Saudi Arabia. © 2013 Wiley Publishing Asia Pty Ltd.

A systematic review of the association between consumption of sugar-containing beverages and excess weight gain among children under age 12.

PubMed

Frantsve-Hawley, Julie; Bader, James D; Welsh, Jean A; Wright, J Timothy

2017-06-01

A systematic review was conducted to address this clinical question: Does consumption of (non-dairy) sugar-containing beverages (SCBs) among children under age 12 result in excess weight gain? The authors searched four databases for controlled trials (randomized and non-randomized) and cohort studies published in English through March 29, 2016: PubMed, EMBASE, Cochrane Database of Systematic Reviews, CINAHL. Initial and full-text screening, data abstraction, and risk of bias assessment were performed independently and in duplicate. Thirty-eight studies met inclusion criteria for this systematic review. One was a randomized controlled trial, and 37 were cohort studies. Though the results of these studies were mixed, the majority demonstrated a statistically significant positive association between SCB consumption in children under age 12 and total adiposity and central adiposity. In contrast, most studies that assessed 100 percent fruit juice consumption only with either total adiposity or central adiposity did not support an association. Among only children under age 5 at baseline, no studies examined central adiposity, but nearly all studies examining SCBs and total adiposity, and a majority examining only fruit juice consumption, demonstrated a statistically significant positive association. Our results support a statistically significant positive association between SCBs and total and central adiposity among children under age 12. This association is most consistent for total adiposity among children <5. Our results for 100 percent fruit juice only suggest differences by age, as most studies among those < 12 were negative but most among those <5 were positive. © 2017 American Association of Public Health Dentistry.

The impact of migration on the sexual health, behaviours and attitudes of Central and East European gay/bisexual men in London.

PubMed

Mole, Richard C M; Parutis, Violetta; Gerry, Christopher J; Burns, Fiona M

2014-02-01

Building on an earlier quantitative study which found that gay/bisexual men from Central and Eastern Europe were at greater risk of sexual ill health following migration to the UK, the aim of this qualitative study is to explore how the process of migration itself may have influenced the migrants' sexual behaviour and attitudes. To address these questions, we conducted 17 in-depth interviews in London with gay/bisexual male migrants from Central and Eastern Europe, drawing on Fisher and Fisher's Information-Motivation-Behavioral Skills model as an interpretive framework. We find that the sexual behaviours of our respondents have been significantly influenced by the process of migration itself. In particular, extricating themselves from the traditional systems of social control in their home societies and having greater access to gay venues in London resulted in their increased sexual activity, particularly in the first phase of migration. High-risk sexual behaviour was found to be a factor of sexual mixing, the use of commercial sex and perceptions of risk in the UK vis-á-vis Central and Eastern Europe, with each of these factors also influenced by the process of migration. Risk-prevention behaviour depended upon the possession of appropriate risk-prevention information, motivation to use condoms and appropriate behavioural skills, with the latter two factors in particular influenced by social mores in the home country and the UK. The interviews suggested a number of migration-related factors that increased the STI and HIV risk for these migrants. A number of potentially important policy recommendations stem from our analysis.

Constraining the Single-degenerate Channel of Type Ia Supernovae with Stable Iron-group Elements in SNR 3C 397

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dave, Pranav; Kashyap, Rahul; Fisher, Robert

Recent Suzaku X-ray spectra of supernova remnant (SNR) 3C 397 indicate enhanced stable iron group element abundances of Ni, Mn, Cr, and Fe. Seeking to address key questions about the progenitor and explosion mechanism of 3C 397, we compute nucleosynthetic yields from a suite of multidimensional hydrodynamics models in the near-Chandrasekhar-mass, single-degenerate paradigm for Type Ia supernovae (SNe Ia). Varying the progenitor white dwarf (WD) internal structure, composition, ignition, and explosion mechanism, we find that the best match to the observed iron peak elements of 3C 397 are dense (central density ≥6 × 10{sup 9} g cm{sup −3}), low-carbon WDsmore » that undergo a weak, centrally ignited deflagration, followed by a subsequent detonation. The amount of {sup 56}Ni produced is consistent with a normal or bright normal SNe Ia. A pure deflagration of a centrally ignited, low central density (≃2 × 10{sup 9} g cm{sup −3}) progenitor WD, frequently considered in the literature, is also found to produce good agreement with 3C 397 nucleosynthetic yields, but leads to a subluminous SN Ia event, in conflict with X-ray line width data. Additionally, in contrast to prior work that suggested a large supersolar metallicity for the WD progenitor for SNR 3C 397, we find satisfactory agreement for solar- and subsolar-metallicity progenitors. We discuss a range of implications our results have for the single-degenerate channel.« less

Views of adolescents on addressing violence in semi-rural secondary schools in Mafikeng, North West province.

PubMed

Mosome, Connie; Poggenpoel, Marie; Myburgh, Chris

2011-11-17

Violence is a public health problem and often an issue of criminal justice.Violence in schools is a worldwide phenomenon and exposes adolescents to premature death. The purpose of this study was to explore and describe adolescents' views on addressing violence in semi-rural secondary schools in Mafikeng. A qualitative, explorative, descriptive and contextual research design was utilised. Purposive sampling was used to select adolescents from semi-rural secondary schools in Mafikeng who fell between the ages of 13 and 20 years and who were involved in community youth groups or associations. In-depth focus group discussion using audiotape, reflexive notes and naïve sketches were used for data collection. The central question which was asked was 'What are the adolescents' views on addressing violence in semi-rural secondary schools?' Data were analysed by means of open coding. The results showed that adolescents understood the complexities associated with violence in this country, and they suggested multiple approaches and interventions. The adolescents were of the opinion that responsible communication patterns in the school environment could build healthy relationships between learners and educators and lead to a decrease in violence in the school setting. They also felt that enforcement of a secure teaching environment through encouragement of behavioural and attitudinal change guided by school codes of conduct and provision of firm security will help reduce violence in schools.

Working with Second Language Learners: Answers to Teachers' Top Ten Questions.

ERIC Educational Resources Information Center

Cary, Stephen

This book aims to provide practical, research-informed answers to the questions most frequently asked by teachers of second language learners. Every question targets one of the key instructional issues teachers must address to ensure success for their second language students. Included among the questions are: How do I assess a student's English?…

System considerations

NASA Technical Reports Server (NTRS)

Alper, M. E.

1978-01-01

Closing remarks and a general summary of the Alternative Energy Systems Seminar are presented. It was concluded from the seminar that the DOE programs described were focused on trying to make a commercial market develop for the various systems. The question addressed is how this is going to happen. To address this question, social, economical, political and technical aspects are considered with major emphasis placed on systems engineering to provide low cost efficient systems.

LATIST: A Performance Support Tool for Integrating Technologies into Defense Acquisition University Learning Assets

DTIC Science & Technology

2011-07-01

TECHNOLOGIES INTO DEFENSE ACqUISITION UNIVERSITY LEARNING ASSETS Nada Dabbagh, Kevin Clark, Susan Dass , Salim Al Waaili, Sally Byrd, Susan...demographic data, four Likert- scale questions that targeted respondents’ familiarity with ALT, and one Likert- scale question addressing the...use of technology in learning with under- served populations. (E-mail address: kclark6@gmu.edu) Ms. Susan Dass has over 20 years’ experi- ence in

Rethinking schools of public health: a strategic alliance model.

PubMed

Moloughney, Brent W; Skinner, Harvey A

2006-01-01

Canada is in the midst of rejuvenation of public health organizations, mandates and infrastructure. Major planning exercises are underway regarding public health human resources, where academic institutions have a key role to play. To what extent could schools of public health be part of the solution? Many universities across Canada are considering or in the process of implementing MPH programs (some 17 programs planned and/or underway) and possible schools of public health. However, concerns are raised about critical mass, quality and standards. We encourage innovation and debate about ways to enhance collaborative and structural arrangements for education programs. A school of public health model might emerge from this, but so too might other models. Also, novel types of organizational structure need consideration. One example is a "strategic alliance" model that is broad-based, integrative and adaptive--building on the interdisciplinary focus needed for addressing public health concerns in the 21st century. From our perspective, the central question is: what (new) types of organizational structures and, equally important, collaborative networks will enable Canada to strengthen its public health workforce so that it may better address local and global challenges to public health?

Reflecting on how we remember the personal past: missing components in the study of memory appraisal and theoretical implications.

PubMed

Foley, Mary Ann

2018-05-01

The current paper offers a selective review of the study of memory appraisal, focusing on recollections of the personal past, with the goal to bring attention to a missing component in this study. To date, memory appraisal studies have concentrated on participants' assessments of the content of their personal recollections (e.g., their perceptual detail and story-like feel), including beliefs about the accuracy of that content. Participants' assessments of reflection processes accompanying their recollections (e.g., a sense of piecing-together recollection fragments) have yet to be extensively examined. The lack of information on process-based appraisals is related to prior studies' procedural constraints (e.g., kinds of cue prompts and their timing, minimal opportunities for reflection). Reasons for addressing this missing component provide the central themes of the paper. The reasons emerge from the analysis of autobiographical cueing studies, including integration of narrative research studies and autobiographical works. The analysis leads to suggestions for future research involving the use of personal narratives that are intended to address critiques of reconstruction accounts and unresolved questions in the study of memory appraisal.

How expectations shape pain.

PubMed

Atlas, Lauren Y; Wager, Tor D

2012-06-29

Pain is highly modifiable by psychological factors, including expectations. However, pain is a complex phenomenon, and expectations may work by influencing any number of processes that underlie the construction of pain. Neuroimaging has begun to provide a window into these brain processes, and how expectations influence them. In this article, we review findings regarding expectancy effects on brain markers of nociception and how expectations lead to changes in subjective pain. We address both expectations about treatments (placebo analgesia and nocebo effects) and expectations about the environment (e.g. expectations about pain itself). The body of work reviewed indicates that expectancies shape pain-intensity processing in the central nervous system, with strong effects on nociceptive portions of insula, cingulate and thalamus. Expectancy effects on subjective experience are driven by responses in these regions as well as regions less reliably activated by changes in noxious input, including the dorsolateral prefrontal cortex and the orbitofrontal cortex. Thus, multiple systems are likely to interact and mediate the pain-modulatory effects of expectancies. Finally, we address open questions regarding the psychological processes likely to play an intervening role in expectancy effects on pain. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Analytical and numerical analysis of inverse optimization problems: conditions of uniqueness and computational methods

PubMed Central

Zatsiorsky, Vladimir M.

2011-01-01

One of the key problems of motor control is the redundancy problem, in particular how the central nervous system (CNS) chooses an action out of infinitely many possible. A promising way to address this question is to assume that the choice is made based on optimization of a certain cost function. A number of cost functions have been proposed in the literature to explain performance in different motor tasks: from force sharing in grasping to path planning in walking. However, the problem of uniqueness of the cost function(s) was not addressed until recently. In this article, we analyze two methods of finding additive cost functions in inverse optimization problems with linear constraints, so-called linear-additive inverse optimization problems. These methods are based on the Uniqueness Theorem for inverse optimization problems that we proved recently (Terekhov et al., J Math Biol 61(3):423–453, 2010). Using synthetic data, we show that both methods allow for determining the cost function. We analyze the influence of noise on the both methods. Finally, we show how a violation of the conditions of the Uniqueness Theorem may lead to incorrect solutions of the inverse optimization problem. PMID:21311907

A Nominal Balloon Instrument Payload to Address Questions from the Planetary Decadal Survey

NASA Astrophysics Data System (ADS)

Young, Eliot; Kremic, Tibor; Dankanich, John

The Planetary Science Decadal Survey (entitled "Visions and Voyages for Planetary Science in the Decade 2013 - 2022", available online at https://solarsystem.nasa.gov/2013decadal/) serves as a roadmap for activities to be pursued by the Planetary Science Division of NASA's Science Mission Directorate. This document outlines roughly 200 key research areas and questions in chapters covering different parts of the solar system (e.g., Mars, Small Bodies, etc.). We have reviewed the Decadal Survey to assess whether any of the key questions can be addressed by high altitude balloon-borne payloads. Although some questions can only be answered by in situ experiments, we found that approximately one quarter of the key questions were well suited to balloon payloads. In many of those cases, balloons were competitive or superior to other existing facilities, including HST, SOFIA or Keck telescopes. We will present specific telescope and instrument bench designs that are capable of addressing key questions in the Decadal Survey. The instrument bench takes advantage of two of the main benefits of high-altitude observations: diffraction-limited imaging in visible and UV wavelengths and unobstructed spectroscopy in near-IR (1 - 5 microns) wavelengths. Our optical prescription produces diffraction-limited PSFs in both visible and IR beams. We will discuss pointing and thermal stability, two of the main challenges facing a balloon-borne telescope.

Seattle Central Questions: Institutional and Educational Effectiveness, 2001.

ERIC Educational Resources Information Center

Bystrom, Valerie, Ed.; Kempen, Laurie, Ed.

2001-01-01

The aim of this newsletter, published twice a year by the office of Institutional Planning and Research at Seattle Central Community College (Washington), is to help Seattle Central faculty and staff gain access to the institutional data they need, and to help them link and integrate their various planning and assessment activities without…

Answering Your Questions about AIDS.

ERIC Educational Resources Information Center

Kalichman, Seth C.

This book focuses on AIDS education and answers 350 commonly asked questions about Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) taken from questions addressed to two major urban AIDS hotlines (Milwaukee, Wisconsin, and Houston, Texas). Chapter 1, "HIV - The Virus That Causes AIDS," discusses: the HIV…

Draft evidence report : traumatic brain injury and commercial motor vehicle driver safety (comprehensive review).

DOT National Transportation Integrated Search

2009-03-30

Purpose of this evidence report is to address several key questions posed by the Federal Motor Carrier Safety Administration : Key question 1: What is the impact of traumatic brain injury on crash risk/driving performance? Key question 2: What factor...

Discriminatory Questions and Applicant Reactions in the Employment Interview.

ERIC Educational Resources Information Center

Saks, Alan M.; And Others

This study investigated the effects of discriminatory interview questions on applicants' perceptions and intentions toward an organization. Participants included 118 graduate business students (59 percent male), average age of 31 with more than eight years of full-time work experience. Discriminatory questions addressed handicaps, plans for…

How much detail and accuracy is required in plant growth sub-models to address questions about optimal management strategies in agricultural systems?

PubMed Central

Renton, Michael

2011-01-01

Background and aims Simulations that integrate sub-models of important biological processes can be used to ask questions about optimal management strategies in agricultural and ecological systems. Building sub-models with more detail and aiming for greater accuracy and realism may seem attractive, but is likely to be more expensive and time-consuming and result in more complicated models that lack transparency. This paper illustrates a general integrated approach for constructing models of agricultural and ecological systems that is based on the principle of starting simple and then directly testing for the need to add additional detail and complexity. Methodology The approach is demonstrated using LUSO (Land Use Sequence Optimizer), an agricultural system analysis framework based on simulation and optimization. A simple sensitivity analysis and functional perturbation analysis is used to test to what extent LUSO's crop–weed competition sub-model affects the answers to a number of questions at the scale of the whole farming system regarding optimal land-use sequencing strategies and resulting profitability. Principal results The need for accuracy in the crop–weed competition sub-model within LUSO depended to a small extent on the parameter being varied, but more importantly and interestingly on the type of question being addressed with the model. Only a small part of the crop–weed competition model actually affects the answers to these questions. Conclusions This study illustrates an example application of the proposed integrated approach for constructing models of agricultural and ecological systems based on testing whether complexity needs to be added to address particular questions of interest. We conclude that this example clearly demonstrates the potential value of the general approach. Advantages of this approach include minimizing costs and resources required for model construction, keeping models transparent and easy to analyse, and ensuring the model is well suited to address the question of interest. PMID:22476477

Public health workforce: challenges and policy issues

PubMed Central

Beaglehole, Robert; Dal Poz, Mario R

2003-01-01

This paper reviews the challenges facing the public health workforce in developing countries and the main policy issues that must be addressed in order to strengthen the public health workforce. The public health workforce is diverse and includes all those whose prime responsibility is the provision of core public health activities, irrespective of their organizational base. Although the public health workforce is central to the performance of health systems, very little is known about its composition, training or performance. The key policy question is: Should governments invest more in building and supporting the public health workforce and infrastructure to ensure the more effective functioning of health systems? Other questions concern: the nature of the public health workforce, including its size, composition, skills, training needs, current functions and performance; the appropriate roles of the workforce; and how the workforce can be strengthened to support new approaches to priority health problems. The available evidence to shed light on these policy issues is limited. The World Health Organization is supporting the development of evidence to inform discussion on the best approaches to strengthening public health capacity in developing countries. WHO's priorities are to build an evidence base on the size and structure of the public health workforce, beginning with ongoing data collection activities, and to map the current public health training programmes in developing countries and in Central and Eastern Europe. Other steps will include developing a consensus on the desired functions and activities of the public health workforce and developing a framework and methods for assisting countries to assess and enhance the performance of public health training institutions and of the public health workforce. PMID:12904251

Strong Gravitational Lensing as a Probe of Gravity, Dark-Matter and Super-Massive Black Holes

NASA Astrophysics Data System (ADS)

Koopmans, L.V.E.; Barnabe, M.; Bolton, A.; Bradac, M.; Ciotti, L.; Congdon, A.; Czoske, O.; Dye, S.; Dutton, A.; Elliasdottir, A.; Evans, E.; Fassnacht, C.D.; Jackson, N.; Keeton, C.; Lasio, J.; Moustakas, L.; Meneghetti, M.; Myers, S.; Nipoti, C.; Suyu, S.; van de Ven, G.; Vegetti, S.; Wucknitz, O.; Zhao, H.-S.

Whereas considerable effort has been afforded in understanding the properties of galaxies, a full physical picture, connecting their baryonic and dark-matter content, super-massive black holes, and (metric) theories of gravity, is still ill-defined. Strong gravitational lensing furnishes a powerful method to probe gravity in the central regions of galaxies. It can (1) provide a unique detection-channel of dark-matter substructure beyond the local galaxy group, (2) constrain dark-matter physics, complementary to direct-detection experiments, as well as metric theories of gravity, (3) probe central super-massive black holes, and (4) provide crucial insight into galaxy formation processes from the dark matter point of view, independently of the nature and state of dark matter. To seriously address the above questions, a considerable increase in the number of strong gravitational-lens systems is required. In the timeframe 2010-2020, a staged approach with radio (e.g. EVLA, e-MERLIN, LOFAR, SKA phase-I) and optical (e.g. LSST and JDEM) instruments can provide 10^(2-4) new lenses, and up to 10^(4-6) new lens systems from SKA/LSST/JDEM all-sky surveys around ~2020. Follow-up imaging of (radio) lenses is necessary with moderate ground/space-based optical-IR telescopes and with 30-50m telescopes for spectroscopy (e.g. TMT, GMT, ELT). To answer these fundamental questions through strong gravitational lensing, a strong investment in large radio and optical-IR facilities is therefore critical in the coming decade. In particular, only large-scale radio lens surveys (e.g. with SKA) provide the large numbers of high-resolution and high-fidelity images of lenses needed for SMBH and flux-ratio anomaly studies.

Crustal and upper mantle structure of the Hangay Dome, central Mongolia

NASA Astrophysics Data System (ADS)

Stachnik, J. C.; Meltzer, A.; Tsaagan, B.; Munkhuu, U.; Russo, R.; Souza, S.; Martin, P.

2013-12-01

The origin and support of high topography within continental interiors away from active tectonic margins remains a fundamental question in the dynamics and deformation of continents. The Hangay Dome in central Mongolia is one such region that is a broad regional uplift with average elevation of about 2 km, sitting between two large strike-slip faults, the Bulnay Fault to the north and the Gobi-Altay Fault to the south. Both of these faults are seismically active and have experienced M8+ earthquakes as recently as 1957. This portion of the Mongolian Plateau is approximately 300 km south of the Baikal Rift and located at the northern margin of the diffuse-deformation field in Central Asia, adjacent to the Siberian Craton. From previous research, the dynamic support of the Hangay Dome has been attributed to both crustal thickening and low density upper mantle material. However, seismic data leading to these interpretations have been limited to global tomographic models and sparse regional sampling of the wave field leaving the question unresolved. To address this major question in plate tectonic theory, in June 2012 a temporary IRIS/PASSCAL/University of Florida array of 72 seismic stations was deployed around the Hangay Dome to determine lithospheric structure in the region. Preliminary results from the first of two years of data are shown from receiver function analysis, ambient noise surface wave tomography, and teleseismic travel time residual analysis. Using teleseismic waveform records from over 300 earthquakes above M5.5 between 30 and 90 degrees epicentral distance, crustal thickness measurements from H-k stacking of receiver functions range from 42 km to 57 km across the array, with thicker crust beneath the highest topography. At each station the bulk crustal Vp/Vs ratio is also determined with median value for the array of 1.77, perhaps indicating a more mafic composition crust in the region.Teleseismic P-wave travel time residuals generally diminish from south to north across the array consistent with thinning crust, however the depth resolution and magnitude of seismic wavespeed anomalies will be further explored with three-dimensional finite-frequency tomography. Constraints on crustal shear wave velocity from ambient noise surface wave tomography complement both the receiver function analysis and teleseismic tomography. Initial inversions of phase velocity dispersion curves in the central Hangay indicate an average crustal Vs of 3.6 km/s within the Hangay Dome, which translates to an average Vp of 6.4 km/s using Vp/Vs of 1.77. Further refinement of current analysis and an additional year of recording will reveal the first high resolution lithospheric scale model in the region.

On framing the research question and choosing the appropriate research design.

PubMed

Parfrey, Patrick S; Ravani, Pietro

2015-01-01

Clinical epidemiology is the science of human disease investigation with a focus on diagnosis, prognosis, and treatment. The generation of a reasonable question requires definition of patients, interventions, controls, and outcomes. The goal of research design is to minimize error, to ensure adequate samples, to measure input and output variables appropriately, to consider external and internal validities, to limit bias, and to address clinical as well as statistical relevance. The hierarchy of evidence for clinical decision-making places randomized controlled trials (RCT) or systematic review of good quality RCTs at the top of the evidence pyramid. Prognostic and etiologic questions are best addressed with longitudinal cohort studies.

On framing the research question and choosing the appropriate research design.

PubMed

Parfrey, Patrick; Ravani, Pietro

2009-01-01

Clinical epidemiology is the science of human disease investigation with a focus on diagnosis, prognosis, and treatment. The generation of a reasonable question requires the definition of patients, interventions, controls, and outcomes. The goal of research design is to minimize error, ensure adequate samples, measure input and output variables appropriately, consider external and internal validities, limit bias, and address clinical as well as statistical relevance. The hierarchy of evidence for clinical decision making places randomized controlled trials (RCT) or systematic review of good quality RCTs at the top of the evidence pyramid. Prognostic and etiologic questions are best addressed with longitudinal cohort studies.

The Basic Epistemological Questions--Are There Also Valid Answers?

ERIC Educational Resources Information Center

Oderman, Dale B.

Epistemology is the branch of philosophy that seeks answers to two main questions: How do we know? and How do we know we know? This paper is concerned with how four major schools of thought have addressed these questions and the implications that their answers to these questions have for education. The paper begins by discussing how four major…

The Role of Special Education Administrators in Addressing Contextual Factors When Implementing Comprehensive School Reform in Response to the Mandate of the No Child Left behind Act of 2001 (P.L. 107-110)

ERIC Educational Resources Information Center

Darensbourg, Kennith Houston

2011-01-01

This study is designed to identify the effective implementation practices that special education administrators enact to alleviate the negative and enforce the positive effects of contextual factors when implementing comprehensive school reform. Two research questions were designed to address this issue. Research Question One sought to identify…

Utilizing Social Media to Study Information-Seeking and Ethical Issues in Gene Therapy

PubMed Central

Robillard, Julie M; Whiteley, Louise; Johnson, Thomas Wade; Lim, Jonathan; Wasserman, Wyeth W

2013-01-01

Background The field of gene therapy is rapidly evolving, and while hopes of treating disorders of the central nervous system and ethical concerns have been articulated within the academic community, little is known about views and opinions of different stakeholder groups. Objective To address this gap, we utilized social media to investigate the kind of information public users are seeking about gene therapy and the hopes, concerns, and attitudes they express. Methods We conducted a content analysis of questions containing the keywords “gene therapy” from the Q&A site “Yahoo! Answers” for the 5-year period between 2006 and 2010. From the pool of questions retrieved (N=903), we identified those containing at least one theme related to ethics, environment, economics, law, or society (n=173) and then characterized the content of relevant answers (n=399) through emergent coding. Results The results show that users seek a wide range of information regarding gene therapy, with requests for scientific information and ethical issues at the forefront of enquiry. The question sample reveals high expectations for gene therapy that range from cures for genetic and nongenetic diseases to pre- and postnatal enhancement of physiological attributes. Ethics questions are commonly expressed as fears about the impact of gene therapy on self and society. The answer sample echoes these concerns but further suggests that the acceptability of gene therapy varies depending on the specific application. Conclusions Overall, the findings highlight the powerful role of social media as a rich resource for research into attitudes toward biomedicine and as a platform for knowledge exchange and public engagement for topics relating to health and disease. PMID:23470490

ADAPT.DCU at TREC LiveQA: A Sentence Retrieval based Approach to Live Question Answering

DTIC Science & Technology

2015-11-20

list of conceptually similar questions from an index of previously asked on “ Yahoo ! An- swers”. We then extract the best matching sentences from the...answer Japanese why questions. The work in Surdeanu et al. (2011) address the problem of ranking answers to non-factoid how questions from Yahoo ...answering real questions from Yahoo ! Answers in real time. each participant needed to submit a web service application that on receiving a question responds

Theory of mind and central coherence in adults with high-functioning autism or Asperger syndrome.

PubMed

Beaumont, Renae; Newcombe, Peter

2006-07-01

The study investigated theory of mind and central coherence abilities in adults with high-functioning autism (HFA) or Asperger syndrome (AS) using naturalistic tasks. Twenty adults with HFA/AS correctly answered significantly fewer theory of mind questions than 20 controls on a forced-choice response task. On a narrative task, there were no differences in the proportion of mental state words between the two groups, although the participants with HFA/AS were less inclined to provide explanations for characters' mental states. No between-group differences existed on the central coherence questions of the forced-choice response task, and the participants with HFA/AS included an equivalent proportion of explanations for non-mental state phenomena in their narratives as did controls. These results support the theory of mind deficit account of autism spectrum disorders, and suggest that difficulties in mental state attribution cannot be exclusively attributed to weak central coherence.

Unpacking the "Black Box" of Social Programs and Policies: Introduction

ERIC Educational Resources Information Center

Solmeyer, Anna R.; Constance, Nicole

2015-01-01

Traditionally, evaluation has primarily tried to answer the question "Does a program, service, or policy work?" Recently, more attention is given to questions about variation in program effects and the mechanisms through which program effects occur. Addressing these kinds of questions requires moving beyond assessing average program…

The Global Common Good and the Future of Academic Professionals

ERIC Educational Resources Information Center

Shaker, Genevieve G.

2016-01-01

Can the higher education faculty sustain itself as a profession? And why does this question matter as much as more frequently asked questions regarding access, costs, quality, governance, and competitiveness? This special issue of "Higher Learning Research Communications" seeks to address these questions by posing as a unifying concept…

Mothers' Speech Addressed to One-, Two-, and Three-Year-Old Normal Children

ERIC Educational Resources Information Center

Longhurst, Thomas M.; Stepanich, Lyanne

1975-01-01

Analysis of mother-child interaction data for 36 children and their mothers revealed that the three groups of mothers' verbal interactions differed significantly in their mean length of utterance, percentage of yes-no questions, percentage of information questions, and percentage of clarification questions. (Author/CS)

Anticipatory governance for social-ecological resilience.

PubMed

Boyd, Emily; Nykvist, Björn; Borgström, Sara; Stacewicz, Izabela A

2015-01-01

Anticipation is increasingly central to urgent contemporary debates, from climate change to the global economic crisis. Anticipatory practices are coming to the forefront of political, organizational, and citizens' society. Research into anticipation, however, has not kept pace with public demand for insights into anticipatory practices, their risks and uses. Where research exists, it is deeply fragmented. This paper seeks to identify how anticipation is defined and understood in the literature and to explore the role of anticipatory practice to address individual, social, and global challenges. We use a resilience lens to examine these questions. We illustrate how varying forms of anticipatory governance are enhanced by multi-scale regional networks and technologies and by the agency of individuals, drawing from an empirical case study on regional water governance of Mälaren, Sweden. Finally, we discuss how an anticipatory approach can inform adaptive institutions, decision making, strategy formation, and societal resilience.

The globalisation strategies of five Asian tobacco companies: An analytical framework

PubMed Central

Lee, Kelley; Eckhardt, Jappe

2017-01-01

ABSTRACT With 30% of the world’s smokers, two million deaths annually from tobacco use, and rising levels of tobacco consumption, the Asian region is recognised as central to the future of global tobacco control. There is less understanding, however, of how Asian tobacco companies with regional and global aspirations are contributing to the global burden of tobacco-related disease and death. This introductory article sets out the background and rationale for this special issue on ‘The Emergence of Asian Tobacco Companies: Implications for Global Health Governance’. The article discusses the core questions to be addressed and presents an analytical framework for assessing the globalisation strategies of Asian tobacco firms. The article also discusses the selection of the five case studies, namely as independent companies in Asia which have demonstrated concerted ambitions to be a major player in the world market. PMID:27884083

Workshop on Past and Present Solar Radiation: The Record in Meteoritic and Lunar Regolith Material

NASA Technical Reports Server (NTRS)

Pepin, R. O. (Compiler); Mckay, D. S. (Compiler)

1986-01-01

The principal question addressed in the workshop was the extent to which asteroidal and lunar regoliths have collected and preserved, in meteoritic regolith breccias and in lunar soils and regolith breccias, a record of the flux, energy, and compositional history of the solar wind and solar flares. Six central discussion topics were identified. They are: (1)Trapped solar wind and flare gases, tracks, and micrometeorite pits in regolith components; (2)Comparison between lunar regolith breccias, meteoritic regolith breccias, and the lunar soil; (3)The special role of regolith breccias and the challenge of dating their times of compaction; (4)Implications of the data for the flux and compositional history of solar particle emission, composition, and physical mechanisms in the solar source regions, and the composition of the early nebula; (5)How and to what extent have records of incident radiation been altered in various types of grains; (6)Future research directions

Secondary Use of Patients’ Electronic Records (SUPER): An Approach for Meeting Specific Data Needs of Clinical and Translational Researchers

PubMed Central

Sholle, Evan T.; Kabariti, Joseph; Johnson, Stephen B.; Leonard, John P.; Pathak, Jyotishman; Varughese, Vinay I.; Cole, Curtis L.; Campion, Thomas R.

2017-01-01

Academic medical centers commonly approach secondary use of electronic health record (EHR) data by implementing centralized clinical data warehouses (CDWs). However, CDWs require extensive resources to model data dimensions and harmonize clinical terminology, which can hinder effective support of the specific and varied data needs of investigators. We hypothesized that an approach that aggregates raw data from source systems, ignores initial modeling typical of CDWs, and transforms raw data for specific research purposes would meet investigator needs. The approach has successfully enabled multiple tools that provide utility to the institutional research enterprise. To our knowledge, this is the first complete description of a methodology for electronic patient data acquisition and provisioning that ignores data harmonization at the time of initial storage in favor of downstream transformation to address specific research questions and applications. PMID:29854228

Co-regulation of female sexual behavior and pregnancy induction: an exploratory synthesis.

PubMed

Erskine, Mary S; Lehmann, Michael L; Cameron, Nicole M; Polston, Eva K

2004-08-31

This paper will review both new and old data that address the question of whether brain mechanisms involved in reproductive function act in a coordinated way to control female sexual behavior and the induction of pregnancy/pseudopregnancy (P/PSP) by vaginocervical stimulation. Although it is clear that female sexual behavior, including pacing behavior, is important for induction of P/PSP, there has been no concerted effort to examine whether or how common mechanisms may control both functions. Because initiation of P/PSP requires that the female receive vaginocervical stimulation, central mechanisms controlling P/PSP may be modulated by or interactive with those that control female sexual behavior. This paper presents a synthesis of the literature and recent data from our lab for the purpose of examining whether there are interactions between behavioral and neuroendocrine mechanisms which reciprocally influence both reproductive functions.

Land surface water cycles observed with satellite sensors

NASA Technical Reports Server (NTRS)

Nghiem, Son V.; Njoku, E. G.; Brakenridge, G. R.; Kim, Y.

2005-01-01

Acceleration of the global water cycle may lead to increased global precipitation, faster evaporation and a consequent exacerbation of hydrologic extreme. In the U.S. national assessment of the potential consequences of climate variability and change, two GCMs (CGCM1 and HadCM2) show a large increase in precipitation in the future over the southwestern U.S. particularly during winter (Felzer and Heard, 1999). Increased precipitation potentially has important impacts on agricultural and water use in the southeast U.S. (Hatch et al., 1999) and in the central Great Plains (Nielsen, 1997). A hurricane model predicts a 40% precipitation increase for severe hurricanes affecting southeastern Florida, which provokes substantially greater flooding that could negate most of the benefits of present water-management practices in this basin (Gutowski et al., 1994). Thus, it is important to observe the hydroclimate on a continuous longterm basis to address the question of increased precipitation in the enhanced water cycle.

The brain's connective core and its role in animal cognition

PubMed Central

Shanahan, Murray

2012-01-01

This paper addresses the question of how the brain of an animal achieves cognitive integration—that is to say how it manages to bring its fullest resources to bear on an ongoing situation. To fully exploit its cognitive resources, whether inherited or acquired through experience, it must be possible for unanticipated coalitions of brain processes to form. This facilitates the novel recombination of the elements of an existing behavioural repertoire, and thereby enables innovation. But in a system comprising massively many anatomically distributed assemblies of neurons, it is far from clear how such open-ended coalition formation is possible. The present paper draws on contemporary findings in brain connectivity and neurodynamics, as well as the literature of artificial intelligence, to outline a possible answer in terms of the brain's most richly connected and topologically central structures, its so-called connective core. PMID:22927569

Evolution of Staphylococcus aureus during human colonization and infection.

PubMed

Fitzgerald, J Ross

2014-01-01

The diversification of bacterial pathogens during infection is central to their capacity to adapt to different anatomical niches, evade the host immune system, and overcome therapeutic challenges. For example, antimicrobial treatment may fail due to the development of resistance during infection, which is often accompanied by transition to a less virulent state during chronic, persistent infection. In this review, the adaptation of the major human pathogen Staphylococcus aureus to its host environment during infection will be discussed, particularly in the context of new sequencing technologies which have opened a gateway towards understanding of the molecular processes underlying those adaptations. We now have the capacity to address previously intractable questions regarding bacterial diversification during infection which will ultimately lead to enhanced understanding of pathogenesis and the nature of epidemics, and will inform the design of effective therapeutic measures. Copyright © 2013 Elsevier B.V. All rights reserved.

Critical thinking in health professions education: summary and consensus statements of the Millennium Conference 2011.

PubMed

Huang, Grace C; Newman, Lori R; Schwartzstein, Richard M

2014-01-01

Critical thinking is central to the function of health care professionals. However, this topic is not explicitly taught or assessed within current programs, yet the need is greater than ever, in an era of information explosion, spiraling health care costs, and increased understanding about metacognition. To address the importance of teaching critical thinking in health professions education, the Shapiro Institute for Education and Research and the Josiah Macy Jr. Foundation jointly sponsored the Millennium Conference 2011 on Critical Thinking. Teams of physician and nurse educators were selected through an application process. Attendees proposed strategies for integrating principles of critical thinking more explicitly into health professions curricula. Working in interprofessional, multi-institutional groups, participants tackled questions about teaching, assessment, and faculty development. Deliberations were summarized into consensus statements. Educational leaders participated in a structured dialogue about the enhancement of critical thinking in health professions education and recommend strategies to teach critical thinking.

The globalisation strategies of five Asian tobacco companies: An analytical framework.

PubMed

Lee, Kelley; Eckhardt, Jappe

2017-03-01

With 30% of the world’s smokers, two million deaths annually from tobacco use, and rising levels of tobacco consumption, the Asian region is recognised as central to the future of global tobacco control. There is less understanding, however, of how Asian tobacco companies with regional and global aspirations are contributing to the global burden of tobacco-related disease and death. This introductory article sets out the background and rationale for this special issue on ‘The Emergence of Asian Tobacco Companies: Implications for Global Health Governance’. The article discusses the core questions to be addressed and presents an analytical framework for assessing the globalisation strategies of Asian tobacco firms. The article also discusses the selection of the five case studies, namely as independent companies in Asia which have demonstrated concerted ambitions to be a major player in the world market.

When should psychiatrists seek criminal prosecution of assaultive psychiatric inpatients?

PubMed

Ho, Justin; Ralston, D Christopher; McCullough, Laurence B; Coverdale, John H

2009-08-01

This Open Forum commentary reviews the ethical considerations relevant to the question of prosecuting assaultive psychiatric patients, with particular attention to the significance that should be attached to the arguments generated by those considerations. A comprehensive literature search was conducted incorporating the terms "assaultive patients," "ethics," "psychiatric inpatients," and "law." The literature of professional medical ethics was applied to identify relevant domains of ethical argument. Five domains were identified: fiduciary obligations of physicians to assaultive and other patients; obligations to staff members; professional virtues of compassion, self-sacrifice, and self-effacement; retributive justice; and the patient's right to confidentiality. The content of each domain is explained, and guidance is provided on how to assess the relative strengths of ethical argument within each domain. All five domains must be explicitly addressed in order to make ethically disciplined judgments about whether to seek prosecution. A distinctive feature of this ethical analysis is the central importance of the professional virtues.

No departure to "Pandora"? Using critical phenomenology to differentiate "naive" from "reflective" experience in psychiatry and psychosomatic medicine (A comment on Schwartz and Wiggins, 2010)

PubMed Central

2010-01-01

The mind-body problem lies at the heart of the clinical practice of both psychiatry and psychosomatic medicine. In their recent publication, Schwartz and Wiggins address the question of how to understand life as central to the mind-body problem. Drawing on their own use of the phenomenological method, we propose that the mind-body problem is not resolved by a general, evocative appeal to an all encompassing life-concept, but rather falters precisely at the insurmountable difference between "natural" and a "reflective" experience built into phenomenological method itself. Drawing on the works of phenomenologically oriented thinkers, we describe life as inherently "teleological" without collapsing life with our subjective perspective, or stepping over our epistemological limits. From the phenomenology it can be demonstrated that the hypothetical teleological qualities are a reflective reconstruction modelled on human behavioural structure. PMID:21040525

Cultural prototypes and dimensions of honor.

PubMed

Cross, Susan E; Uskul, Ayse K; Gerçek-Swing, Berna; Sunbay, Zeynep; Alözkan, Cansu; Günsoy, Ceren; Ataca, Bilge; Karakitapoglu-Aygün, Zahide

2014-02-01

Research evidence and theoretical accounts of honor point to differing definitions of the construct in differing cultural contexts. The current studies address the question "What is honor?" using a prototype approach in Turkey and the Northern United States. Studies 1a/1b revealed substantial differences in the specific features generated by members of the two groups, but Studies 2 and 3 revealed cultural similarities in the underlying dimensions of self-respect, moral behavior, and social status/respect. Ratings of the centrality and personal importance of these factors were similar across the two groups, but their association with other relevant constructs differed. The tripartite nature of honor uncovered in these studies helps observers and researchers alike understand how diverse responses to situations can be attributed to honor. Inclusion of a prototype analysis into the literature on honor cultures can provide enhanced coverage of the concept that may lead to testable hypotheses and new theoretical developments.

Ethics of emergent information and communication technology applications in humanitarian medical assistance.

PubMed

Hunt, Matthew; Pringle, John; Christen, Markus; Eckenwiler, Lisa; Schwartz, Lisa; Davé, Anushree

2016-07-01

New applications of information and communication technology (ICT) are shaping the way we understand and provide humanitarian medical assistance in situations of disaster, disease outbreak or conflict. Each new crisis appears to be accompanied by advancements in humanitarian technology, leading to significant improvements in the humanitarian aid sector. However, ICTs raise ethical questions that warrant attention. Focusing on the context of humanitarian medical assistance, we review key domains of ICT innovation. We then discuss ethical challenges and uncertainties associated with the development and application of new ICTs in humanitarian medical assistance, including avoiding harm, ensuring privacy and security, responding to inequalities, demonstrating respect, protecting relationships, and addressing expectations. In doing so, we emphasize the centrality of ethics in humanitarian ICT design, application and evaluation. © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Studying the transient magnetar 3XMMJ185246.6+003317 close to SNR Kes 79

NASA Astrophysics Data System (ADS)

Murray, Stephen

2014-09-01

We have discovered a new transient AXP just south of SNR Kes 79. It has the longest period among transient AXPs and the second longest period among isolated X-ray NSs. It is also only the third low-B magnetar. We propose two 10 ks ACIS-I observations, separated by about six months, to monitor the activity of the transient AXP, which was in a quiescent state from late 2012 to late 2013 and is expected to have a duty cycle of less than 10%. We plan to use these two observations to start our long-term campaign on the AXP and Kes 79, which will address important questions like the nature of this rare, low-B, transient AXP, its connection with Kes 79, the activity of the central compact object at the center of Kes 79 and the non-thermal and ejecta emission from Kes 79.

Inferring human history in East Asia from Y chromosomes.

PubMed

Wang, Chuan-Chao; Li, Hui

2013-06-03

East Asia harbors substantial genetic, physical, cultural and linguistic diversity, but the detailed structures and interrelationships of those aspects remain enigmatic. This question has begun to be addressed by a rapid accumulation of molecular anthropological studies of the populations in and around East Asia, especially by Y chromosome studies. The current Y chromosome evidence suggests multiple early migrations of modern humans from Africa via Southeast Asia to East Asia. After the initial settlements, the northward migrations during the Paleolithic Age shaped the genetic structure in East Asia. Subsequently, recent admixtures between Central Asian immigrants and northern East Asians enlarged the genetic divergence between southern and northern East Asia populations. Cultural practices, such as languages, agriculture, military affairs and social prestige, also have impacts on the genetic patterns in East Asia. Furthermore, application of Y chromosome analyses in the family genealogy studies offers successful showcases of the utility of genetics in studying the ancient history.

Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

PubMed Central

Artzy-Randrup, Yael; Rorick, Mary M; Day, Karen; Chen, Donald; Dobson, Andrew P; Pascual, Mercedes

2012-01-01

The coexistence of multiple independently circulating strains in pathogen populations that undergo sexual recombination is a central question of epidemiology with profound implications for control. An agent-based model is developed that extends earlier ‘strain theory’ by addressing the var gene family of Plasmodium falciparum. The model explicitly considers the extensive diversity of multi-copy genes that undergo antigenic variation via sequential, mutually exclusive expression. It tracks the dynamics of all unique var repertoires in a population of hosts, and shows that even under high levels of sexual recombination, strain competition mediated through cross-immunity structures the parasite population into a subset of coexisting dominant repertoires of var genes whose degree of antigenic overlap depends on transmission intensity. Empirical comparison of patterns of genetic variation at antigenic and neutral sites supports this role for immune selection in structuring parasite diversity. DOI: http://dx.doi.org/10.7554/eLife.00093.001 PMID:23251784

Life is pretty meaningful.

PubMed

Heintzelman, Samantha J; King, Laura A

2014-09-01

The human experience of meaning in life is widely viewed as a cornerstone of well-being and a central human motivation. Self-reports of meaning in life relate to a host of important functional outcomes. Psychologists have portrayed meaning in life as simultaneously chronically lacking in human life as well as playing an important role in survival. Examining the growing literature on meaning in life, we address the question "How meaningful is life, in general?" We review possible answers from various psychological sources, some of which anticipate that meaning in life should be low and others that it should be high. Summaries of epidemiological data and research using two self-report measures of meaning in life suggest that life is pretty meaningful. Diverse samples rate themselves significantly above the midpoint on self-reports of meaning in life. We suggest that if meaning in life plays a role in adaptation, it must be commonplace, as our analysis suggests. (c) 2014 APA, all rights reserved.

A core review of temperature regimens and neuroprotection during cardiopulmonary bypass: does rewarming rate matter?

PubMed

Grigore, Alina M; Murray, Catherine Friederich; Ramakrishna, Harish; Djaiani, George

2009-12-01

Despite a half century of research and the implementation of various risk-reduction strategies among clinicians and basic scientists, patients continue to experience strokes and cognitive dysfunction related to the use of cardiopulmonary bypass (CPB) for cardiac surgery. One strategy to reduce these detrimental effects has been the use of hypothermia. Although numerous studies have addressed the issue, the question of whether the use of hypothermia during CPB attenuates the impact of central nervous system consequences remains unresolved. However, data clearly demonstrate that hyperthermia is to be avoided in the perioperative period, necessitating careful rewarming strategies if hypothermia is used during CPB. Selecting and understanding the impact of the temperature-monitoring site is important to accurately estimate cerebral temperature and to avoid inadvertent surges in brain temperature. In this article, we review the literature regarding the impact of hypothermia and rewarming rates during cardiac surgery.

A genomic perspective on the generation and maintenance of genetic diversity in herbivorous insects

PubMed Central

Gloss, Andrew D.; Groen, Simon C.; Whiteman, Noah K.

2017-01-01

Understanding the processes that generate and maintain genetic variation within populations is a central goal in evolutionary biology. Theory predicts that some of this variation is maintained as a consequence of adapting to variable habitats. Studies in herbivorous insects have played a key role in confirming this prediction. Here, we highlight theoretical and conceptual models for the maintenance of genetic diversity in herbivorous insects, empirical genomic studies testing these models, and pressing questions within the realm of evolutionary and functional genomic studies. To address key gaps, we propose an integrative approach combining population genomic scans for adaptation, genome-wide characterization of targets of selection through experimental manipulations, mapping the genetic architecture of traits influencing fitness, and functional studies. We also stress the importance of studying the maintenance of genetic variation across biological scales—from variation within populations to divergence among populations—to form a comprehensive view of adaptation in herbivorous insects. PMID:28736510

Unexpected earthquake hazard revealed by Holocene rupture on the Kenchreai Fault (central Greece): Implications for weak sub-fault shear zones

NASA Astrophysics Data System (ADS)

Copley, Alex; Grützner, Christoph; Howell, Andy; Jackson, James; Penney, Camilla; Wimpenny, Sam

2018-03-01

High-resolution elevation models, palaeoseismic trenching, and Quaternary dating demonstrate that the Kenchreai Fault in the eastern Gulf of Corinth (Greece) has ruptured in the Holocene. Along with the adjacent Pisia and Heraion Faults (which ruptured in 1981), our results indicate the presence of closely-spaced and parallel normal faults that are simultaneously active, but at different rates. Such a configuration allows us to address one of the major questions in understanding the earthquake cycle, specifically what controls the distribution of interseismic strain accumulation? Our results imply that the interseismic loading and subsequent earthquakes on these faults are governed by weak shear zones in the underlying ductile crust. In addition, the identification of significant earthquake slip on a fault that does not dominate the late Quaternary geomorphology or vertical coastal motions in the region provides an important lesson in earthquake hazard assessment.

Family learning research in museums: An emerging disciplinary matrix?

NASA Astrophysics Data System (ADS)

Ellenbogen, Kirsten M.; Luke, Jessica J.; Dierking, Lynn D.

2004-07-01

Thomas Kuhn's notion of a disciplinary matrix provides a useful framework for investigating the growth of research on family learning in and from museums over the last decade. To track the emergence of this disciplinary matrix we consider three issues. First are shifting theoretical perspectives that result in new shared language, beliefs, values, understandings, and assumptions about what counts as family learning. Second are realigning methodologies, driven by underlying disciplinary assumptions about how research in this arena is best conducted, what questions should be addressed, and criteria for valid and reliable evidence. Third is resituating the focus of our research to make the family central to what we study, reflecting a more holistic understanding of the family as an educational institution within larger learning infrastructure. We discuss research that exemplifies these three issues and demonstrates the ways in which shifting theoretical perspectives, realigning methodologies, and resituating research foci signal the existence of a nascent disciplinary matrix.

Pedagogical Content Knowledge Development and Pre-Service Physics Teacher Education: A Case Study

NASA Astrophysics Data System (ADS)

Sperandeo-Mineo, R. M.; Fazio, C.; Tarantino, G.

2006-09-01

This paper addresses the question of how to develop prospective teachers' pedagogical content knowledge (PCK) in science teacher education. The main focus is on the knowledge transformation process and on the cognitive strategies used to shift prospective teachers' explanations within the domain of modelling thermal physical phenomena. This study investigates the development of PCK within a group of 28 pre-service physics teachers during the first semester of their two-year post-graduate teacher education program. It focuses on the central issue of the relationships between observable phenomena, like macroscopic thermal properties of matter and their interpretation and/or explanation in terms of corpuscular characteristics and/or thermodynamics theory. The strategy is based on the consideration that knowledge transformation is not a one-way process from subject matter knowledge to pedagogical content knowledge, as literature suggests, but a bidirectional process involving deepening of subject matter knowledge and increasing awareness of pedagogical issues.

Inferring human history in East Asia from Y chromosomes

PubMed Central

2013-01-01

East Asia harbors substantial genetic, physical, cultural and linguistic diversity, but the detailed structures and interrelationships of those aspects remain enigmatic. This question has begun to be addressed by a rapid accumulation of molecular anthropological studies of the populations in and around East Asia, especially by Y chromosome studies. The current Y chromosome evidence suggests multiple early migrations of modern humans from Africa via Southeast Asia to East Asia. After the initial settlements, the northward migrations during the Paleolithic Age shaped the genetic structure in East Asia. Subsequently, recent admixtures between Central Asian immigrants and northern East Asians enlarged the genetic divergence between southern and northern East Asia populations. Cultural practices, such as languages, agriculture, military affairs and social prestige, also have impacts on the genetic patterns in East Asia. Furthermore, application of Y chromosome analyses in the family genealogy studies offers successful showcases of the utility of genetics in studying the ancient history. PMID:23731529

Effects of Individual Differences in Working Memory on Plan Presentational Choices

PubMed Central

Tintarev, Nava; Masthoff, Judith

2016-01-01

This paper addresses research questions that are central to the area of visualization interfaces for decision support: (RQ1) whether individual user differences in working memory should be considered when choosing how to present visualizations; (RQ2) how to present the visualization to support effective decision making and processing; and (RQ3) how to evaluate the effectiveness of presentational choices. These questions are addressed in the context of presenting plans, or sequences of actions, to users. The experiments are conducted in several domains, and the findings are relevant to applications such as semi-autonomous systems in logistics. That is, scenarios that require the attention of humans who are likely to be interrupted, and require good performance but are not time critical. Following a literature review of different types of individual differences in users that have been found to affect the effectiveness of presentational choices, we consider specifically the influence of individuals' working memory (RQ1). The review also considers metrics used to evaluate presentational choices, and types of presentational choices considered. As for presentational choices (RQ2), we consider a number of variants including interactivity, aggregation, layout, and emphasis. Finally, to evaluate the effectiveness of plan presentational choices (RQ3) we adopt a layered-evaluation approach and measure performance in a dual task paradigm, involving both task interleaving and evaluation of situational awareness. This novel methodology for evaluating visualizations is employed in a series of experiments investigating presentational choices for a plan. A key finding is that emphasizing steps (by highlighting borders) can improve effectiveness on a primary task, but only when controlling for individual variation in working memory. PMID:27899905

Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment.

PubMed

Henderson, Gail E; Peay, Holly L; Kroon, Eugene; Cadigan, Rosemary Jean; Meagher, Karen; Jupimai, Thidarat; Gilbertson, Adam; Fisher, Jill; Ormsby, Nuchanart Q; Chomchey, Nitiya; Phanuphak, Nittaya; Ananworanich, Jintanat; Rennie, Stuart

2018-04-01

Though antiretroviral therapy is the standard of care for people living with HIV, its treatment limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early-phase cure trials, particularly those that include analytic treatment interruption (ATI), involve uncertain and potentially high risk, with minimal chance of clinical benefit. Some question whether such trials should be offered, given the risk/benefit imbalance, and whether those who choose to participate are acting rationally. We address these questions through a longitudinal decision-making study nested in a Thai acute HIV research cohort.In-depth interviews revealed central themes about decisions to join. Participants felt they possessed an important identity as members of the acute cohort, viewing their bodies as uniquely suited to both testing and potentially benefiting from HIV cure approaches. While acknowledging risks of ATI, most perceived they were given an opportunity to interrupt treatment, to test their own bodies and increase normalcy in a safe, highly monitored circumstance. They were motivated by potential benefits to themselves, the investigators and larger acute cohort, and others with HIV. They believed their own trial experiences and being able to give back to the community were sufficient to offset participation risks.These decisions were driven by the specific circumstances experienced by our participants. Judging risk/benefit ratios without appreciating these lived experiences can lead to false determinations of irrational decision- making. While this does not minimise vital oversight considerations about risk reduction and protection from harm, it argues for inclusion of a more participant-centered approach. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

ESPGHAN-NASPGHAN Guidelines for the Evaluation and Treatment of Gastrointestinal and Nutritional Complications in Children With Esophageal Atresia-Tracheoesophageal Fistula.

PubMed

Krishnan, Usha; Mousa, Hayat; Dall'Oglio, Luigi; Homaira, Nusrat; Rosen, Rachel; Faure, Christophe; Gottrand, Frédéric

2016-11-01

Esophageal atresia (EA) is one of the most common congenital digestive anomalies. With improvements in surgical techniques and intensive care treatments, the focus of care of these patients has shifted from mortality to morbidity and quality-of-life issues. These children face gastrointestinal (GI) problems not only in early childhood but also through adolescence and adulthood. There is, however, currently a lack of a systematic approach to the care of these patients. The GI working group of International Network on Esophageal Atresia comprises members from ESPGHAN/NASPGHAN and was charged with the task of developing uniform evidence-based guidelines for the management of GI complications in children with EA. Thirty-six clinical questions addressing the diagnosis, treatment, and prognosis of the common GI complications in patients with EA were formulated. Questions on the diagnosis, and treatment of gastroesophageal reflux, management of "cyanotic spells," etiology, investigation and management of dysphagia, feeding difficulties, anastomotic strictures, congenital esophageal stenosis in EA patients were addressed. The importance of excluding eosinophilic esophagitis and associated GI anomalies in symptomatic patients with EA is discussed as is the quality of life of these patients and the importance of a systematic transition of care to adulthood. A systematic literature search was performed from inception to March 2014 using Embase, MEDLINE, the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Clinical Trials, and PsychInfo databases. The approach of the Grading of Recommendations Assessment, Development and Evaluation was applied to evaluate outcomes. During 2 consensus meetings, all recommendations were discussed and finalized. The group members voted on each recommendation, using the nominal voting technique. Expert opinion was used where no randomized controlled trials were available to support the recommendation.

Effects of Individual Differences in Working Memory on Plan Presentational Choices.

PubMed

Tintarev, Nava; Masthoff, Judith

2016-01-01

This paper addresses research questions that are central to the area of visualization interfaces for decision support: (RQ1) whether individual user differences in working memory should be considered when choosing how to present visualizations; (RQ2) how to present the visualization to support effective decision making and processing; and (RQ3) how to evaluate the effectiveness of presentational choices. These questions are addressed in the context of presenting plans, or sequences of actions, to users. The experiments are conducted in several domains, and the findings are relevant to applications such as semi-autonomous systems in logistics. That is, scenarios that require the attention of humans who are likely to be interrupted, and require good performance but are not time critical. Following a literature review of different types of individual differences in users that have been found to affect the effectiveness of presentational choices, we consider specifically the influence of individuals' working memory (RQ1). The review also considers metrics used to evaluate presentational choices, and types of presentational choices considered. As for presentational choices (RQ2), we consider a number of variants including interactivity, aggregation, layout, and emphasis. Finally, to evaluate the effectiveness of plan presentational choices (RQ3) we adopt a layered-evaluation approach and measure performance in a dual task paradigm, involving both task interleaving and evaluation of situational awareness. This novel methodology for evaluating visualizations is employed in a series of experiments investigating presentational choices for a plan. A key finding is that emphasizing steps (by highlighting borders) can improve effectiveness on a primary task, but only when controlling for individual variation in working memory.

Driving research in infant and children's nutrition: a perspective on industry.

PubMed

Rai, Deshanie; Larson, Brian

2009-05-01

As part of the workshop entitled "Early Risk Determinants and Later Health Outcomes: Implications for Research Prioritization and the Food Supply" (8-9 July 2008, Washington, DC), which was cosponsored by the International Life Sciences Institute of North America and the International Life Sciences Institute Research Foundation, representatives of the food industry discussed the practical application of nutrition science. Nutrition plays a key role in guiding health outcomes throughout the life cycle. In particular, the prenatal, postnatal, and early childhood periods are extremely sensitive to the presence of appropriate nutrition. A growing body of evidence shows that early nutrition may program the unborn and the infant's key physiologic systems, including the endocrine, cardiovascular, and central nervous systems, to influence later life outcomes. While scientists in academia continue to explore the multifactorial nature of early risk determinants and later life outcomes at a mechanistic and basic science level, it is important to understand the potential of the infant and child food industries to address questions such as what factors have been noted to drive research in these sectors of the food industry. How can scientists in these industries work alongside the scientists in academia and in government to set priorities, make decisions around these health issues, and translate academic insights into innovative nutritional solutions for the benefit of public health? Given the commitment of the infant and child food industries to deliver scientifically supported early life nutrition, it is easy to understand why this industry would work in partnership with both the scientists in academia and the government to identify a means of addressing the fundamental questions of this workshop.

A Statistical Approach Reveals Designs for the Most Robust Stochastic Gene Oscillators

PubMed Central

2016-01-01

The engineering of transcriptional networks presents many challenges due to the inherent uncertainty in the system structure, changing cellular context, and stochasticity in the governing dynamics. One approach to address these problems is to design and build systems that can function across a range of conditions; that is they are robust to uncertainty in their constituent components. Here we examine the parametric robustness landscape of transcriptional oscillators, which underlie many important processes such as circadian rhythms and the cell cycle, plus also serve as a model for the engineering of complex and emergent phenomena. The central questions that we address are: Can we build genetic oscillators that are more robust than those already constructed? Can we make genetic oscillators arbitrarily robust? These questions are technically challenging due to the large model and parameter spaces that must be efficiently explored. Here we use a measure of robustness that coincides with the Bayesian model evidence, combined with an efficient Monte Carlo method to traverse model space and concentrate on regions of high robustness, which enables the accurate evaluation of the relative robustness of gene network models governed by stochastic dynamics. We report the most robust two and three gene oscillator systems, plus examine how the number of interactions, the presence of autoregulation, and degradation of mRNA and protein affects the frequency, amplitude, and robustness of transcriptional oscillators. We also find that there is a limit to parametric robustness, beyond which there is nothing to be gained by adding additional feedback. Importantly, we provide predictions on new oscillator systems that can be constructed to verify the theory and advance design and modeling approaches to systems and synthetic biology. PMID:26835539

Scale in Remote Sensing and GIS: An Advancement in Methods Towards a Science of Scale

NASA Technical Reports Server (NTRS)

Quattrochi, Dale A.

1998-01-01

The term "scale", both in space and time, is central to remote sensing and geographic information systems (GIS). The emergence and widespread use of GIS technologies, including remote sensing, has generated significant interest in addressing scale as a generic topic, and in the development and implementation of techniques for dealing explicitly with the vicissitudes of scale as a multidisciplinary issue. As science becomes more complex and utilizes databases that are capable of performing complex space-time data analyses, it becomes paramount that we develop the tools and techniques needed to operate at multiple scales, to work with data whose scales are not necessarily ideal, and to produce results that can be aggregated or disaggregated in ways that suit the decision-making process. Contemporary science is constantly coping with compromises, and the data available for a particular study rarely fit perfectly with the scales at which the processes being investigated operate, or the scales that policy-makers require to make sound, rational decisions. This presentation discusses some of the problems associated with scale as related to remote sensing and GIS, and describes some of the questions that need to be addressed in approaching the development of a multidisciplinary "science of scale". Techniques for dealing with multiple scaled data that have been developed or explored recently are described as a means for recognizing scale as a generic issue, along with associated theory and tools that can be of simultaneous value to a large number of disciplines. These can be used to seek answers to a host of interrelated questions in the interest of providing a formal structure for the management and manipulation of scale and its universality as a key concept from a multidisciplinary perspective.

Scale in Remote Sensing and GIS: An Advancement in Methods Towards a Science of Scale

NASA Technical Reports Server (NTRS)

Quattrochi, D. A.

1998-01-01

The term "scale", both in space and time, is central to remote sensing and Geographic Information Systems (GIS). The emergence and widespread use of GIS technologies, including remote sensing, has generated significant interest in addressing scale as a generic topic, and in the development and implementation of techniques for dealing explicitly with the vicissitudes of scale as a multidisciplinary issue. As science becomes more complex and utilizes databases that are capable of performing complex space-time data analyses, it becomes paramount that we develop the tools and techniques needed to operate at multiple scales, to work with data whose scales are not necessarily ideal, and to produce results that can be aggregated or disaggregated ways that suit the decision-making process. Contemporary science is constantly coping with compromises, and the data available for a particular study rarely fit perfectly with the scales at which the processes being investigated operate, or the scales that policy-makers require to make sound, rational decisions. This presentation discusses some of the problems associated with scale as related to remote sensing and GIS, and describes some of the questions that need to be addressed in approaching the development of a multidisciplinary "science of scale". Techniques for dealing with multiple scaled data that have been developed or explored recently are described as a means for recognizing scale as a generic issue, along with associated theory and tools that can be of simultaneous value to a large number of disciplines. These can be used to seek answers to a host of interrelated questions in the interest of providing a formal structure for the management and manipulation of scale and its universality as a key concept from a multidisciplinary perspective.

Research Use as Learning: The Case of Fundamental Change in School District Central Offices

ERIC Educational Resources Information Center

Honig, Meredith I.; Venkateswaran, Nitya; McNeil, Patricia

2017-01-01

Districts nationwide have launched efforts to fundamentally change their central offices to support improved teaching and learning for all students and are turning to research for help. The research provides promising guides but is challenging to use. What happens when central offices try? We explored that question in six districts using…

Land

EPA Pesticide Factsheets

The ROE is divided into 5 themes: Air, Water, Land, Human Exposure and Health and Ecological Condition. From these themes, the report indicators address fundamental questions that the ROE attempts to answer. For Land there are 5 questions.

Questioning in Tongan Science Classrooms: A Pilot Study to Identify Current Practice, Barriers and Facilitators

ERIC Educational Resources Information Center

Bay, Jacquie L.; Fohoko, Fehi; La'Akulu, Mumui; Leota, Ofa; Pulotu, Lesieli; Tu'Ipuloto, Sina; Tutoe, Salesi; Tovo, Oliveti; Vekoso, Ana; Pouvalu, Emeli H.

2016-01-01

Questioning is central to the development of scientific and health literacies. In exploring this concept, Tongan science teachers hypothesized that their ability to use and encourage questioning presented challenges in the context of Tongan social and cultural norms. This study set out to develop a peer-to-peer protocol to enable teachers to…

Beyond Questioning: Inquiry Strategies and Cognitive and Affective Elements of Jewish Education

ERIC Educational Resources Information Center

Sigel, Irving E.; Kress, Jeffrey S.; Elias, Maurice J.

2007-01-01

Questioning-asking has not only long been seen as a central component of Jewish educational practice but has also been thought to be part of a broader culture of Judaism. In this article, we apply cognitive-developmental theories to advance the discussion of the use of questioning in Jewish education. Such theories allow Jewish educators to more…

Why and How. The Future of the Central Questions of Consciousness

PubMed Central

Havlík, Marek; Kozáková, Eva; Horáček, Jiří

2017-01-01

In this review, we deal with two central questions of consciousness how and why, and we outline their possible future development. The question how refers to the empirical endeavor to reveal the neural correlates and mechanisms that form consciousness. On the other hand, the question why generally refers to the “hard problem” of consciousness, which claims that empirical science will always fail to provide a satisfactory answer to the question why is there conscious experience at all. Unfortunately, the hard problem of consciousness will probably never completely disappear because it will always have its most committed supporters. However, there is a good chance that its weight and importance will be highly reduced by empirically tackling consciousness in the near future. We expect that future empirical endeavor of consciousness will be based on a unifying brain theory and will answer the question as to what is the function of conscious experience, which will in turn replace the implications of the hard problem. The candidate of such a unifying brain theory is predictive coding, which will have to explain both perceptual consciousness and conscious mind-wandering in order to become the truly unifying theory of brain functioning. PMID:29075226

Privacy Impact Assessment for the Central Data Exchange

EPA Pesticide Factsheets

The Central Data Exchange collects personally identifiable information, including personal answers to security questions. Learn how this data will be collected in the system, how it will be used, access to the data, and the purpose of data collection.

Expert music performance: cognitive, neural, and developmental bases.

PubMed

Brown, Rachel M; Zatorre, Robert J; Penhune, Virginia B

2015-01-01

In this chapter, we explore what happens in the brain of an expert musician during performance. Understanding expert music performance is interesting to cognitive neuroscientists not only because it tests the limits of human memory and movement, but also because studying expert musicianship can help us understand skilled human behavior in general. In this chapter, we outline important facets of our current understanding of the cognitive and neural basis for music performance, and developmental factors that may underlie musical ability. We address three main questions. (1) What is expert performance? (2) How do musicians achieve expert-level performance? (3) How does expert performance come about? We address the first question by describing musicians' ability to remember, plan, execute, and monitor their performances in order to perform music accurately and expressively. We address the second question by reviewing evidence for possible cognitive and neural mechanisms that may underlie or contribute to expert music performance, including the integration of sound and movement, feedforward and feedback motor control processes, expectancy, and imagery. We further discuss how neural circuits in auditory, motor, parietal, subcortical, and frontal cortex all contribute to different facets of musical expertise. Finally, we address the third question by reviewing evidence for the heritability of musical expertise and for how expertise develops through training and practice. We end by discussing outlooks for future work. © 2015 Elsevier B.V. All rights reserved.

A review of population data utilization in beef cattle research.

PubMed

Jones, R; Langemeier, M

2010-04-01

Controlled experimentation has been the most common source of research data in most biological sciences. However, many research questions lend themselves to the use of population data, or combinations of population data and data resulting from controlled experimentation. Studies of important economic outcomes, such as efficiency, profits, and costs, lend themselves particularly well to this type of analysis. Analytical methods that have been most commonly applied to population data in studies related to livestock production and management include statistical regression and mathematical programming. In social sciences, such as applied economics, it has become common to utilize more than one method in the same study to provide answers to the various questions at hand. Of course, care must be taken to ensure that the methods of analysis are appropriately applied; however, a wide variety of beef industry research questions are being addressed using population data. Issues related to data sources, aggregation levels, and consistency of collection often surface when using population data. These issues are addressed by careful consideration of the questions being addressed and the costs of data collection. Previous research across a variety of cattle production and marketing issues provides a broad foundation upon which to build future research. There is tremendous opportunity for increased use of population data and increased collaboration across disciplines to address issues of importance to the cattle industry.

Rethinking Meta-Analysis: Applications for Air Pollution Data and Beyond

PubMed Central

Goodman, Julie E; Petito Boyce, Catherine; Sax, Sonja N; Beyer, Leslie A; Prueitt, Robyn L

2015-01-01

Meta-analyses offer a rigorous and transparent systematic framework for synthesizing data that can be used for a wide range of research areas, study designs, and data types. Both the outcome of meta-analyses and the meta-analysis process itself can yield useful insights for answering scientific questions and making policy decisions. Development of the National Ambient Air Quality Standards illustrates many potential applications of meta-analysis. These applications demonstrate the strengths and limitations of meta-analysis, issues that arise in various data realms, how meta-analysis design choices can influence interpretation of results, and how meta-analysis can be used to address bias and heterogeneity. Reviewing available data from a meta-analysis perspective can provide a useful framework and impetus for identifying and refining strategies for future research. Moreover, increased pervasiveness of a meta-analysis mindset—focusing on how the pieces of the research puzzle fit together—would benefit scientific research and data syntheses regardless of whether or not a quantitative meta-analysis is undertaken. While an individual meta-analysis can only synthesize studies addressing the same research question, the results of separate meta-analyses can be combined to address a question encompassing multiple data types. This observation applies to any scientific or policy area where information from a variety of disciplines must be considered to address a broader research question. PMID:25969128

Questionnaire design: carry-over effects of overall acceptance question placement and pre-evaluation instructions on overall acceptance scores in central location tests.

PubMed

Bastian, Mauresa; Eggett, Dennis L; Jefferies, Laura K

2015-02-01

Question placement and usage of pre-evaluation instructions (PEI) in questionnaires for food sensory analysis may bias consumers' scores via carry-over effects. Data from consumer sensory panels previously conducted at a central location, spanning 11 years and covering a broad range of food product categories, were compiled. Overall acceptance (OA) question placement was studied with categories designated as first (the first evaluation question following demographic questions), after nongustation questions (immediately following questions that do not require panelists to taste the product), and later (following all other hedonic and just-about-right [JAR] questions, but occasionally before ranking, open-ended comments, and/or intent to purchase questions). Each panel was categorized as having or not having PEI in the questionnaire; PEI are instructions that appear immediately before the first evaluation question and show panelists all attributes they will evaluate before receiving test samples. Postpanel surveys were administered regarding the self-reported effect of PEI on panelists' evaluation experience. OA scores were analyzed and compared (1) between OA question placement categories and (2) between panels with and without PEI. For most product categories, OA scores tended to be lower when asked later in the questionnaire, suggesting evidence of a carry-over effect. Usage of PEI increased OA scores by 0.10 of a 9-point hedonic scale point, which is not practically significant. Postpanel survey data showed that presence of PEI typically improved the panelists' experience. Using PEI does not appear to introduce a meaningful carry-over effect. © 2015 Institute of Food Technologists®

Ecological Condition

EPA Pesticide Factsheets

The ROE is divided into 5 themes: Air, Water, Land, Human Exposure and Health and Ecological Condition. From these themes, the report indicators address fundamental questions that the ROE attempts to answer. For ecological condition there are 5 questions.

Do Lions Purr? And Why Are There No Green Mammals?

ERIC Educational Resources Information Center

Stewart, Doug

1995-01-01

An environmental magazine answers 10 questions about wildlife that readers often write and ask. Questions address the behavior of animals and evolutionary reasons for biological adaptations suggested by research. (LZ)

2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine Symposium

PubMed Central

Spitalnik, Steven L.; Triulzi, Darrell; Devine, Dana V.; Dzik, Walter H.; Eder, Anne F.; Gernsheimer, Terry; Josephson, Cassandra D.; Kor, Daryl J.; Luban, Naomi L. C.; Roubinian, Nareg H.; Mondoro, Traci; Welniak, Lisbeth A.; Zou, Shimian; Glynn, Simone

2015-01-01

On March 25-26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the NIH campus in Bethesda, MD, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5-10 years, and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three “classical” transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Prior to the meeting, four Working Groups, one for each area, prepared five major questions for discussion along with a list of 5-10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in Keynote lectures, small group breakout sessions, and large group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine. PMID:26260861

Clinical Practice Guideline: Safe Medication Use in the ICU.

PubMed

Kane-Gill, Sandra L; Dasta, Joseph F; Buckley, Mitchell S; Devabhakthuni, Sandeep; Liu, Michael; Cohen, Henry; George, Elisabeth L; Pohlman, Anne S; Agarwal, Swati; Henneman, Elizabeth A; Bejian, Sharon M; Berenholtz, Sean M; Pepin, Jodie L; Scanlon, Mathew C; Smith, Brian S

2017-09-01

To provide ICU clinicians with evidence-based guidance on safe medication use practices for the critically ill. PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, CINAHL, Scopus, and ISI Web of Science for relevant material to December 2015. Based on three key components: 1) environment and patients, 2) the medication use process, and 3) the patient safety surveillance system. The committee collectively developed Population, Intervention, Comparator, Outcome questions and quality of evidence statements pertaining to medication errors and adverse drug events addressing the key components. A total of 34 Population, Intervention, Comparator, Outcome questions, five quality of evidence statements, and one commentary on disclosure was developed. Subcommittee members were assigned selected Population, Intervention, Comparator, Outcome questions or quality of evidence statements. Subcommittee members completed their Grading of Recommendations Assessment, Development, and Evaluation of the question with his/her quality of evidence assessment and proposed strength of recommendation, then the draft was reviewed by the relevant subcommittee. The subcommittee collectively reviewed the evidence profiles for each question they developed. After the draft was discussed and approved by the entire committee, then the document was circulated among all members for voting on the quality of evidence and strength of recommendation. The committee followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation system to determine quality of evidence and strength of recommendations. This guideline evaluates the ICU environment as a risk for medication-related events and the environmental changes that are possible to improve safe medication use. Prevention strategies for medication-related events are reviewed by medication use process node (prescribing, distribution, administration, monitoring). Detailed considerations to an active surveillance system that includes reporting, identification, and evaluation are discussed. Also, highlighted is the need for future research for safe medication practices that is specific to critically ill patients.

Keys to Success: School Facilities Primer, Questions & Answers 101.

ERIC Educational Resources Information Center

Brady, Jim

This publication provides answers to basic questions to help school board members more fully address the complexities of the planning, design, and construction process in order to maximize the goal of student success. The 101 questions and answers are in the areas of: facility planning; learning environment; information technology; safe schools;…

Risk Factor Analysis and the Youth Question

ERIC Educational Resources Information Center

France, Alan

2008-01-01

This paper is concerned with exploring how in late modernity the "youth question" is being addressed by public policy and what impact this is having on understandings of childhood and youth. Historically the youth question has been shaped by adult anxieties over youth delinquency and their problems of social integration. In late modernity, this is…

Moving Students' Questions out of the Parking Lot

ERIC Educational Resources Information Center

Ness, Molly

2014-01-01

This article provides teachers with ideas on how to address students' self-generated questions. Following a third-grade classroom, the article explores the use of a "parking lot" -- a repository for the seemingly off-task questions which curious students naturally pose. As students encounter informational text with genuine purposes,…

Questions Often Asked about Special Education Services = Preguntas sobre los servicios de educacion especial.

ERIC Educational Resources Information Center

Kupper, Lisa, Ed.

This guide, available in both English and Spanish, answers questions often asked by parents about special education services. Questions and answers address the following topics: where to begin if a parent believes a child needs special education services, services available to very young children, the evaluation process, the Individualized…

How Should Energy Be Defined throughout Schooling?

ERIC Educational Resources Information Center

Bächtold, Manuel

2018-01-01

The question of how to teach energy has been renewed by recent studies focusing on the learning and teaching progressions for this concept. In this context, one question has been, for the most part, overlooked: how should energy be defined throughout schooling? This paper addresses this question in three steps. We first identify and discuss two…

Computational Natural Language Inference: Robust and Interpretable Question Answering

ERIC Educational Resources Information Center

Sharp, Rebecca Reynolds

2017-01-01

We address the challenging task of "computational natural language inference," by which we mean bridging two or more natural language texts while also providing an explanation of how they are connected. In the context of question answering (i.e., finding short answers to natural language questions), this inference connects the question…

Addressing Student Difficulties with Buoyancy

NASA Astrophysics Data System (ADS)

Wagner, D. J.; Cohen, Sam; Moyer, Adam

2009-11-01

This study is part of an ongoing effort to develop a diagnostic test assessing student understanding of fluids. In particular, this paper addresses a question involving density and buoyancy, which was used in the study of reference [1]. The "five blocks" question, which asks students to predict the final location of blocks released from rest when submerged and explain their reasoning, has been administered to hundreds of students in three different introductory courses at Grove City College for the past four years. We used the common student responses to craft a multiple-select version of the five blocks problem in 2008. This paper will present the effects that changing workshop activities have had on student performance on the five block question.

Commentary on Sommer et al. 'A randomized experiment of the effects of including alternative medicine in the mandatory benefit package of health insurance.

PubMed

Heusser, P

2000-03-01

The study by Sommer et al. recently reported in Complementary Therapies in Medicine has been heavily criticised in Switzerland since its original publication. Its major problems are an inadequate reflection of real practice, an inadequate study design relative to the central research objective, questionable value of the applied instrument and procedure for health assessment, methodological and statistical problems, and failure to consider literature relevant to the topic. For these reasons, this experimental study does not allow an answer to its central questions as to costs and effectiveness of complementary medicine made available within Switzerland's mandatory basic health insurance provisions. We propose more practice-related, non-experimental prospective study designs to realistically answer these questions.

"Where is Everybody?" An Account of Fermi's Question

DOE R&D Accomplishments Database

Jones, E. M.

1985-03-01

Enrico Fermi's famous question, now central to debates about the prevalence of extraterrestrial civilizations, arose during a luncheon conversation with Emil Konopinski, Edward Teller, and Herbert York in the summer of 1950. Fermi's companions on that day have provided accounts of the incident.

Fault segmentation: New concepts from the Wasatch Fault Zone, Utah, USA

USGS Publications Warehouse

Duross, Christopher; Personius, Stephen F.; Crone, Anthony J.; Olig, Susan S.; Hylland, Michael D.; Lund, William R.; Schwartz, David P.

2016-01-01

The question of whether structural segment boundaries along multisegment normal faults such as the Wasatch fault zone (WFZ) act as persistent barriers to rupture is critical to seismic hazard analyses. We synthesized late Holocene paleoseismic data from 20 trench sites along the central WFZ to evaluate earthquake rupture length and fault segmentation. For the youngest (<3 ka) and best-constrained earthquakes, differences in earthquake timing across prominent primary segment boundaries, especially for the most recent earthquakes on the north-central WFZ, are consistent with segment-controlled ruptures. However, broadly constrained earthquake times, dissimilar event times along the segments, the presence of smaller-scale (subsegment) boundaries, and areas of complex faulting permit partial-segment and multisegment (e.g., spillover) ruptures that are shorter (~20–40 km) or longer (~60–100 km) than the primary segment lengths (35–59 km). We report a segmented WFZ model that includes 24 earthquakes since ~7 ka and yields mean estimates of recurrence (1.1–1.3 kyr) and vertical slip rate (1.3–2.0 mm/yr) for the segments. However, additional rupture scenarios that include segment boundary spatial uncertainties, floating earthquakes, and multisegment ruptures are necessary to fully address epistemic uncertainties in rupture length. We compare the central WFZ to paleoseismic and historical surface ruptures in the Basin and Range Province and central Italian Apennines and conclude that displacement profiles have limited value for assessing the persistence of segment boundaries but can aid in interpreting prehistoric spillover ruptures. Our comparison also suggests that the probabilities of shorter and longer ruptures on the WFZ need to be investigated.

Mio-Pliocene aridity in the south-central Andes associated with Southern Hemisphere cold periods

PubMed Central

Amidon, William H.; Fisher, G. Burch; Burbank, Douglas W.; Ciccioli, Patricia L.; Alonso, Ricardo N.; Gorin, Andrew L.; Silverhart, Perri H.; Kylander-Clark, Andrew R. C.; Christoffersen, Michael S.

2017-01-01

Although Earth’s climate history is best known through marine records, the corresponding continental climatic conditions drive the evolution of terrestrial life. Continental conditions during the latest Miocene are of particular interest because global faunal turnover is roughly synchronous with a period of global glaciation from ∼6.2–5.5 Ma and with the Messinian Salinity Crisis from ∼6.0–5.3 Ma. Despite the climatic and ecological significance of this period, the continental climatic conditions associated with it remain unclear. We address this question using erosion rates of ancient watersheds to constrain Mio-Pliocene climatic conditions in the south-central Andes near 30° S. Our results show two slowdowns in erosion rate, one from ∼6.1–5.2 Ma and another from 3.6 to 3.3 Ma, which we attribute to periods of continental aridity. This view is supported by synchrony with other regional proxies for aridity and with the timing of glacial ‟cold” periods as recorded by marine proxies, such as the M2 isotope excursion. We thus conclude that aridity in the south-central Andes is associated with cold periods at high southern latitudes, perhaps due to a northward migration of the Southern Hemisphere westerlies, which disrupted the South American Low Level Jet that delivers moisture to southeastern South America. Colder glacial periods, and possibly associated reductions in atmospheric CO2, thus seem to be an important driver of Mio-Pliocene ecological transitions in the central Andes. Finally, this study demonstrates that paleo-erosion rates can be a powerful proxy for ancient continental climates that lie beyond the reach of most lacustrine and glacial archives. PMID:28607045

Exobiology and Future Mars Missions

NASA Technical Reports Server (NTRS)

Mckay, Christopher P. (Editor); Davis, Wanda, L. (Editor)

1989-01-01

Scientific questions associated with exobiology on Mars were considered and how these questions should be addressed on future Mars missions was determined. The mission that provided a focus for discussions was the Mars Rover/Sample Return Mission.

Human Exposure and Health

EPA Pesticide Factsheets

The ROE is divided into 5 themes: Air, Water, Land, Human Exposure and Health and Ecological Condition. From these themes, the report indicators address fundamental questions that the ROE attempts to answer. For human health there are 3 questions.

Comparative anatomy, evolution, and homologies of tetrapod hindlimb muscles, comparison with forelimb muscles, and deconstruction of the forelimb-hindlimb serial homology hypothesis.

PubMed

Diogo, Rui; Molnar, Julia

2014-06-01

For more than two centuries, the idea that the forelimb and hindlimb are serially homologous structures has been accepted without serious question. This study presents the first detailed analysis of the evolution and homologies of all hindlimb muscles in representatives of each major tetrapod group and proposes a unifying nomenclature for these muscles. These data are compared with information obtained previously about the forelimb muscles of tetrapods and the muscles of other gnathostomes in order to address one of the most central and enigmatic questions in evolutionary and comparative anatomy: why are the pelvic and pectoral appendages of gnathostomes generally so similar to each other? An integrative analysis of the new myological data, combined with a review of recent paleontological, developmental, and genetic works and of older studies, does not support serial homology between the structures of these appendages. For instance, many of the strikingly similar forelimb and hindlimb muscles found in each major extant tetrapod taxon were acquired at different geological times and/or have different embryonic origins. These similar muscles are not serial homologues, but the result of evolutionary parallelism/convergence due to a complex interplay of ontogenetic, functional, topological, and phylogenetic constraints/factors. Copyright © 2014 Wiley Periodicals, Inc.

Optimization of Inflammatory Bowel Disease Cohort Studies in Asia.

PubMed

Leung, Wai K

2015-07-01

With the incidence of inflammatory bowel disease (IBD) increasing rapidly in many Asian countries, including Hong Kong, it is important that patient characteristics are better understood. For example, are the phenotypes, behaviors, complications, and even treatment responses found in Asian patients similar to those of their Western counterparts? To formally address these questions, a properly designed local cohort study is needed. Whilst IBD is still relatively uncommon in Asia, the establishment of a local IBD registry will significantly contribute to the answering of these questions. The Hong Kong IBD registry was established to fill the gap in the understanding of IBD patients, and to foster research into IBD in Hong Kong. The Hong Kong IBD registry is a territory-wide registry that includes all public hospitals in Hong Kong. We included all IBD patients who were currently receiving medical care at these hospitals. With the help of the central computer medical record system of the Hospital Authority of Hong Kong, all clinical events, medications usage, endoscopy records, and laboratory results of patients in the registry were captured. Apart from data collection, the registry is also establishing a bio-specimen bank of blood and stool samples of IBD patients for future research. The IBD registry is a very useful platform for population-based studies on IBD in Asia.

Reconstructing Native American Population History

PubMed Central

Reich, David; Patterson, Nick; Campbell, Desmond; Tandon, Arti; Mazieres, Stéphane; Ray, Nicolas; Parra, Maria V.; Rojas, Winston; Duque, Constanza; Mesa, Natalia; García, Luis F.; Triana, Omar; Blair, Silvia; Maestre, Amanda; Dib, Juan C.; Bravi, Claudio M.; Bailliet, Graciela; Corach, Daniel; Hünemeier, Tábita; Bortolini, Maria-Cátira; Salzano, Francisco M.; Petzl-Erler, María Luiza; Acuña-Alonzo, Victor; Aguilar-Salinas, Carlos; Canizales-Quinteros, Samuel; Tusié-Luna, Teresa; Riba, Laura; Rodríguez-Cruz, Maricela; Lopez-Alarcón, Mardia; Coral-Vazquez, Ramón; Canto-Cetina, Thelma; Silva-Zolezzi, Irma; Fernandez-Lopez, Juan Carlos; Contreras, Alejandra V.; Jimenez-Sanchez, Gerardo; Gómez-Vázquez, María José; Molina, Julio; Carracedo, Ángel; Salas, Antonio; Gallo, Carla; Poletti, Giovanni; Witonsky, David B.; Alkorta-Aranburu, Gorka; Sukernik, Rem I.; Osipova, Ludmila; Fedorova, Sardana; Vasquez, René; Villena, Mercedes; Moreau, Claudia; Barrantes, Ramiro; Pauls, David; Excoffier, Laurent; Bedoya, Gabriel; Rothhammer, Francisco; Dugoujon, Jean Michel; Larrouy, Georges; Klitz, William; Labuda, Damian; Kidd, Judith; Kidd, Kenneth; Rienzo, Anna Di; Freimer, Nelson B.; Price, Alkes L.; Ruiz-Linares, Andrés

2013-01-01

The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1–5. One contentious issue is whether the settlement occurred via a single6–8 or multiple streams of migration from Siberia9–15. The pattern of dispersals within the Americas is also poorly understood. To address these questions at higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. We show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call “First American”. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan-speakers on both sides of the Panama Isthmus, who have ancestry from both North and South America. PMID:22801491

Testability and epistemic shifts in modern cosmology

NASA Astrophysics Data System (ADS)

Kragh, Helge

2014-05-01

During the last decade new developments in theoretical and speculative cosmology have reopened the old discussion of cosmology's scientific status and the more general question of the demarcation between science and non-science. The multiverse hypothesis, in particular, is central to this discussion and controversial because it seems to disagree with methodological and epistemic standards traditionally accepted in the physical sciences. But what are these standards and how sacrosanct are they? Does anthropic multiverse cosmology rest on evaluation criteria that conflict with and go beyond those ordinarily accepted, so that it constitutes an "epistemic shift" in fundamental physics? The paper offers a brief characterization of the modern multiverse and also refers to a few earlier attempts to introduce epistemic shifts in the science of the universe. It further discusses the several meanings of testability, addresses the question of falsifiability as a sine qua non for a theory being scientific, and briefly compares the situation in cosmology with the one in systematic biology. Multiverse theory is not generally falsifiable, which has led to proposals from some physicists to overrule not only Popperian standards but also other evaluation criteria of a philosophical nature. However, this is hardly possible and nor is it possible to get rid of explicit philosophical considerations in some other aspects of cosmological research, however advanced it becomes.

Evaluation of the Impact of an Additive Manufacturing Enhanced CubeSat Architecture on the CubeSat Development Process

DTIC Science & Technology

2016-09-15

Investigative Questions This research will quantitatively address the impact of proposed benefits of a 3D printed satellite architecture on the...subsystems of a CubeSat. The objective of this research is to bring a quantitative analysis to the discussion of whether a fully 3D printed satellite...manufacturers to quantitatively address what impact the architecture would have on the subsystems of a CubeSat. Summary of Research Gap, Research Questions, and

Technical notes: when all things are not equal.

PubMed

Wasson, John H

2006-01-01

This article addresses 2 questions. First, how useful is adult patients' information about health and healthcare when they use the Internet for a "health checkup"? We find that patietns' reports are very strongly associated with medical record information for blood pressure, cholesterol, and blood glucose. Second, what are the biases in information from Internet respondents? Although we find that "health checkup" Internet users seem to be representative for patients in actual practice, much more research will be needed to fully address this question.

Hezbollah: The Network and Its Support Systems, Can They be Stopped?

DTIC Science & Technology

2008-06-01

that the use of direct action against Hezbollah Nash Point (2,2) SQ 1,1 2,3 3,4 ALLIES H E Z B O L L A H Hezbollah Security Level Allies...different strategy to defeat them may be in order. Using Hezbollah as an example, this thesis addresses the question of whether the direct military...Using Hezbollah as an example, this thesis addresses the question of whether the direct military approach used to combat terrorist groups, such as Al

Rituximab: 13 open questions after 20years of clinical use.

PubMed

Pavanello, Francesca; Zucca, Emanuele; Ghielmini, Michele

2017-02-01

Rituximab improved the prognosis of all B-cell derived lymphoproliferative diseases, but despite 20years of intensive use, it remains a drug with a number of still obscure characteristics and unanswered questions. These include the mechanism of action and of resistance, the optimal schedule, the interaction with chemotherapy, as well as predictive factors for response rate and duration. Despite being very well tolerated, the question of its long term side effects and the risks of the administration near to a pregnancy have only recently been addressed. Also the indications are still not all clear: rituximab induces remissions as a single agent and improves the effect of chemotherapy, but its use as maintenance or as a substitute for watch and wait is still debated. Also, it is still unclear if its efficacy derives at least partly by reducing the risk of histological transformation in indolent NHL and reducing the risk of CNS relapse in aggressive NHL. Finally, despite of 20years of research, it is still unclear if rituximab can be efficiently substituted by biosimilars or new anti-CD20 antibodies. In this review we address all these questions and analyze the literature addressing these aspects. Copyright © 2016 Elsevier Ltd. All rights reserved.

Construction of Continental Crust at the Central American and Philippines Arc Systems

NASA Astrophysics Data System (ADS)

Whattam, S. A.; Stern, R. J.

2016-12-01

Whether or not magmatic arcs evolve compositionally with time and the processes responsible remain controversial. Resolution of this question requires reconstructing arc geochemical evolution at the level of discrete arc systems, as has been done for IBM, Central America, and the Greater Antilles. Emphasis should be on arcs built on oceanic crust because interaction with continental crust complicates interpretations. The Philippines are a particularly attractive target because this may be the best example where proto-continental crust has been generated and processed in Cretaceous and younger time. Here, we show how this question could be addressed for the Philippines using the well-studied Central American Volcanic Arc System (CAVAS) as an example. For the CAVAS, we avoided the northern arc segment because these are (Guatemala) or maybe (El Salvador) sections built on continental crust. Geochemical and isotopic data were compiled for 1031 samples of lavas and intrusive rocks from the 1100 km-long segment built on thickened, initially plume-derived oceanic crust over its 75 million year lifespan (Panama, Costa Rica, Nicaragua) . The most striking observation is the overall evolution of the CAVAS to more incompatible element enriched and ultimately continental-like compositions with time. Models entailing progressive arc magmatic enrichment are generally supported by the CAVAS record. Progressive enrichment of the oceanic CAVAS with time reflects changes in mantle wedge composition and decreased melting due to arc crust thickening, which was kick-started by the involvement of enriched plume mantle. Progressive crustal thickening and associated changes in the sub-arc thermal regime resulted in decreasing degrees of partial melting over time, which allowed for progressive enrichment of the CAVAS and ultimately the production of continental-like crust in Panama and Costa Rica by 16-10 Ma. Our similar study of the Philippine Arc system is in its infancy but earlier studies have shown that older magmatic rocks are tholeiitic and MORB-like whereas younger ones are invariably calc-alkaline and arc-like. Results of the Philippines Arc study will be compared with the CAVAS and other magmatic arc systems comprised of continental crust.

Providing Opportunities for Argumentation in Science Exam Settings

ERIC Educational Resources Information Center

Swanson, Lauren; Solorza, Ruben; Fissore, Cinzia

2018-01-01

This article explores undergraduates' efforts to engage in scientific argumentation during exam settings. Thirteen undergraduate students enrolled in an environmental science course completed exams with questions linked around a central theme. Three types of questions were used, including those that prompted students to construct scientific…

Ask a SEER Registrar - SEER Registrars

Cancer.gov

First submit questions to your central registry as required and they will submit them to SEER. Use the form on this page to submit questions to SEER staff about coding cancer cases or SEER's reporting guideline materials. Coding and abstracting answers are on SEER Inquiry System website.

An epistemic framing analysis of upper level physics students' use of mathematics

NASA Astrophysics Data System (ADS)

Bing, Thomas Joseph

Mathematics is central to a professional physicist's work and, by extension, to a physics student's studies. It provides a language for abstraction, definition, computation, and connection to physical reality. This power of mathematics in physics is also the source of many of the difficulties it presents students. Simply put, many different activities could all be described as "using math in physics". Expertise entails a complicated coordination of these various activities. This work examines the many different kinds of thinking that are all facets of the use of mathematics in physics. It uses an epistemological lens, one that looks at the type of explanation a student presently sees as appropriate, to analyze the mathematical thinking of upper level physics undergraduates. Sometimes a student will turn to a detailed calculation to produce or justify an answer. Other times a physical argument is explicitly connected to the mathematics at hand. Still other times quoting a definition is seen as sufficient, and so on. Local coherencies evolve in students' thought around these various types of mathematical justifications. We use the cognitive process of framing to model students' navigation of these various facets of math use in physics. We first demonstrate several common framings observed in our students' mathematical thought and give several examples of each. Armed with this analysis tool, we then give several examples of how this framing analysis can be used to address a research question. We consider what effects, if any, a powerful symbolic calculator has on students' thinking. We also consider how to characterize growing expertise among physics students. Framing offers a lens for analysis that is a natural fit for these sample research questions. To active physics education researchers, the framing analysis presented in this dissertation can provide a useful tool for addressing other research questions. To physics teachers, we present this analysis so that it may make them more explicitly aware of the various types of reasoning, and the dynamics among them, that students employ in our physics classes. This awareness will help us better hear students' arguments and respond appropriately.

An Upward Spiral? The Gate Project: A Case Study of the Role of Training in Addressing Homelessness in Central London. Monographs in Continuing Education.

ERIC Educational Resources Information Center

Carter, Julia

In 1990, the London Enterprise Agency, a private sector consortium dedicated to inner-city regeneration in London, established a project to address homelessness. Later called GATE (Guaranteed Accommodation and Training for Employment), the project had three central features: a focus on employment as a means of tackling homelessness; the use of a…

Pedagogy of Discernment, New Wine in Old Skins? A Response to Potgieter

ERIC Educational Resources Information Center

Nieuwenhuis, F. J.

2015-01-01

In his 2014 paper Potgieter presented a number of pertinent questions on education in a post-modern world. In this article I not only challenge some of the views informing these questions but also raise additional questions for debate and critical analysis. Two pertinent issues, both with religious undertones, are addressed, viz.: a) whether the…

Brief Report: Attitudes about Responding to Survey Questions Concerning Childhood Sexual Abuse by Hispanic Female College Students

ERIC Educational Resources Information Center

Ernst, Frederick A.; Salinas, Nancy I.; Perez, Natalie

2009-01-01

In no studies have research participants been asked how they feel about answering questions concerning childhood sexual abuse. We have performed searches from two different search engines again and have found nothing published which specifically addresses this question in the way we have. A questionnaire about childhood sexual abuse was…

New Responses to Enduring Questions in Religious and Theological Education

ERIC Educational Resources Information Center

Siejk, Cate

2011-01-01

This article offers a response to two provocative questions about the relationship of theology to religious education posed by Norma Thompson in her Presidential address given at the annual meeting of APRRE in 1978. I offer contemporary answers to these questions from the perspective of a theological educator. First, I show how feminist theory and…

Three Naive Questions: Addressed to the Modern Educational Optimism

ERIC Educational Resources Information Center

Krstic, Predrag

2016-01-01

This paper aims to question anew the popular and supposedly self-evident affirmation of education, in its modern incarnation as in its historical notion. The "naive" questions suggest that we have recently taken for granted that education ought to be for the masses, that it ought to be upbringing, and that it is better than ignorance.…

An outline of planetary geoscience. [philosophy

NASA Technical Reports Server (NTRS)

1977-01-01

A philosophy for planetary geoscience is presented to aid in addressing a number of major scientific questions; answers to these questions should constitute the basic geoscientific knowledge of the solar system. However, any compilation of major questions or basic knowledge in planetary geoscience involves compromises and somewhat arbitrary boundaries that reflect the prevalent level of understanding at the time.

Is the Use of Labels in Special Education Helpful?

ERIC Educational Resources Information Center

Lauchlan, Fraser; Boyle, Christopher

2007-01-01

In this article we will address the question: is the use of labels in special education helpful? Within this question there are a number of other questions and issues to consider: what is the relationship between labelling and special educational needs? or the relationship between labelling and the allocation of resources?, as well as the more…

Early Childhood Teacher Research: From Questions to Results

ERIC Educational Resources Information Center

Castle, Kathryn

2011-01-01

What is early childhood teacher research and why is it important? How does a teacher researcher formulate a research question and a plan for doing research? How do teachers apply research results to effect change? "Early Childhood Teacher Research" is an exciting new resource that will address the sorts of questions and concerns that pre- and…

Input Consistency in the Acquisition of Questions in Bulgarian and English: A Hypothesis Testing Model

ERIC Educational Resources Information Center

Tornyova, Lidiya

2011-01-01

The goal of this dissertation is to address several major empirical and theoretical issues related to English-speaking children's difficulties with auxiliary use and inversion in questions. The empirical data on English question acquisition are inconsistent due to differences in methods and techniques used. A range of proposals about the source of…

The Woodlands, Texas.

ERIC Educational Resources Information Center

McHaney, Larry J.; Bernhardt, Jerry

1988-01-01

The authors describe the "central project" concept for implementing technology education while addressing education reform. The central project is a topic around which students, teachers, administrators, and the community focus their energies as a team. At McCullough High School (Texas), the central project involved design and…

Relatives and friends queries on a psychologists "question and answer" forum online - authorship and contents.

PubMed

Stjernswärd, Sigrid

2015-03-01

Families living with mental illness can experience added burden and eventually own ill health. National and international guidelines support the development of web based solutions to cost-effectively address health care needs. Mapping patterns of internet use may help tailor interventions to effectively address users' needs. The study's aim was to explore the contents of relatives' and friends' queries on a psychologists' website with professional feedback. All visible questions [n = 59] classified under the website's "helping a relative/friend" category between 20 090 615-20 130 927 were printed out and analyzed using content analysis. The analysis resulted in four categories and subcategories illuminating families'/friends' areas of concern: support to help; concerns with health care; young children's welfare; and repercussions on own health. "Question & Answer" [Q&A] forums can shed light onto health seekers' online behavior and may be a way of addressing families' needs of support and information. Further studies are needed to assess the replies' therapeutic value for their recipients.

A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets.

PubMed

Wasko, Michael J; Pellegrene, Kendy A; Madura, Jeffry D; Surratt, Christopher K

2015-01-01

Hundreds of millions of U.S. dollars are invested in the research and development of a single drug. Lead compound development is an area ripe for new design strategies. Therapeutic lead candidates have been traditionally found using high-throughput in vitro pharmacological screening, a costly method for assaying thousands of compounds. This approach has recently been augmented by virtual screening (VS), which employs computer models of the target protein to narrow the search for possible leads. A variant of VS is fragment-based drug design (FBDD), an emerging in silico lead discovery method that introduces low-molecular weight fragments, rather than intact compounds, into the binding pocket of the receptor model. These fragments serve as starting points for "growing" the lead candidate. Current efforts in virtual FBDD within central nervous system (CNS) targets are reviewed, as is a recent rule-based optimization strategy in which new molecules are generated within a 3D receptor-binding pocket using the fragment as a scaffold. This process not only places special emphasis on creating synthesizable molecules but also exposes computational questions worth addressing. Fragment-based methods provide a viable, relatively low-cost alternative for therapeutic lead discovery and optimization that can be applied to CNS targets to augment current design strategies.

A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets

PubMed Central

Wasko, Michael J.; Pellegrene, Kendy A.; Madura, Jeffry D.; Surratt, Christopher K.

2015-01-01

Hundreds of millions of U.S. dollars are invested in the research and development of a single drug. Lead compound development is an area ripe for new design strategies. Therapeutic lead candidates have been traditionally found using high-throughput in vitro pharmacological screening, a costly method for assaying thousands of compounds. This approach has recently been augmented by virtual screening (VS), which employs computer models of the target protein to narrow the search for possible leads. A variant of VS is fragment-based drug design (FBDD), an emerging in silico lead discovery method that introduces low-molecular weight fragments, rather than intact compounds, into the binding pocket of the receptor model. These fragments serve as starting points for “growing” the lead candidate. Current efforts in virtual FBDD within central nervous system (CNS) targets are reviewed, as is a recent rule-based optimization strategy in which new molecules are generated within a 3D receptor-binding pocket using the fragment as a scaffold. This process not only places special emphasis on creating synthesizable molecules but also exposes computational questions worth addressing. Fragment-based methods provide a viable, relatively low-cost alternative for therapeutic lead discovery and optimization that can be applied to CNS targets to augment current design strategies. PMID:26441817

The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?

PubMed Central

O’Sullivan, Justin M.; Pai, Dave A.; Cridge, Andrew G.; Engelke, David R.; Ganley, Austen R. D.

2016-01-01

The nucleolus is a prominent nuclear structure that is the site of ribosomal RNA (rRNA) transcription, and hence ribosome biogenesis. Cellular demand for ribosomes, and hence rRNA, is tightly linked to cell growth and the rRNA makes up the majority of all the RNA within a cell. To fulfil the cellular demand for rRNA, the ribosomal RNA genes (rDNA) genes are amplified to high copy number and transcribed at very high rates. As such, understanding the rDNA has profound consequences for our comprehension of genome and transcriptional organization in cells. In this review we address the question of whether the nucleolus is a raft adrift the sea of nuclear DNA, or actively contributes to genome organization. We present evidence supporting the idea that the nucleolus, and the rDNA contained therein, play more roles in the biology of the cell than simply ribosome biogenesis. We propose that the nucleolus and the rDNA are central factors in the spatial organization of the genome, and that rapid alterations in nucleolar structure in response to changing conditions manifest themselves in altered genomic structures that have functional consequences. Finally, we discuss some predictions that result from the nucleolus having a central role in nuclear organization. PMID:25436580

Craft, money and mercy: an apothecary's self-portrait in sixteenth-century Bologna.

PubMed

Di Gennaro Splendore, Barbara

2017-04-01

The apothecary occupied a liminal position in early modern society between profit and healing. Finding ways to distance their public image from trade was a common problem for apothecaries across Europe. This article uses the case of a Bolognese apothecary, Filippo Pastarino, to address the question of how early modern apothecaries chose to represent themselves to political authorities and to the wider public. 'Mercy', alongside 'craft', was a pillar of apothecaries' social identity. By contrast, no matter how central financial transactions ('money') were to their activity, apothecaries did not want to be perceived as merchants. Thus, the assistance and advice apothecaries provided to patients and customers resulted as central aspects of their social role. In this context, Bolognese apothecaries aimed to defend their current status, which had been challenged by naturalist Ulysses Aldrovandi, city authorities and local monasteries. However, Pastarino's claims can also be seen as antecedents to the self-legitimizing strategy that seventeenth-century artisans deployed when faced with the need to enhance their new status as natural philosophers. The present study attributes a name, a date of birth and a shop to Filippo Pastarino, revising previous interpretations. More broadly, by focusing on how these artisans defended their position in the city it enriches our understanding of the self-representation of apothecaries.

The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?

PubMed

O'Sullivan, Justin M; Pai, Dave A; Cridge, Andrew G; Engelke, David R; Ganley, Austen R D

2013-06-01

The nucleolus is a prominent nuclear structure that is the site of ribosomal RNA (rRNA) transcription, and hence ribosome biogenesis. Cellular demand for ribosomes, and hence rRNA, is tightly linked to cell growth and the rRNA makes up the majority of all the RNA within a cell. To fulfill the cellular demand for rRNA, the ribosomal RNA (rDNA) genes are amplified to high copy number and transcribed at very high rates. As such, understanding the rDNA has profound consequences for our comprehension of genome and transcriptional organization in cells. In this review, we address the question of whether the nucleolus is a raft adrift the sea of nuclear DNA, or actively contributes to genome organization. We present evidence supporting the idea that the nucleolus, and the rDNA contained therein, play more roles in the biology of the cell than simply ribosome biogenesis. We propose that the nucleolus and the rDNA are central factors in the spatial organization of the genome, and that rapid alterations in nucleolar structure in response to changing conditions manifest themselves in altered genomic structures that have functional consequences. Finally, we discuss some predictions that result from the nucleolus having a central role in nuclear organization.

Modeling and Optimization of Recycled Water Systems to Augment Urban Groundwater Recharge through Underutilized Stormwater Spreading Basins.

PubMed

Bradshaw, Jonathan L; Luthy, Richard G

2017-10-17

Infrastructure systems that use stormwater and recycled water to augment groundwater recharge through spreading basins represent cost-effective opportunities to diversify urban water supplies. However, technical questions remain about how these types of managed aquifer recharge systems should be designed; furthermore, existing planning tools are insufficient for performing robust design comparisons. Addressing this need, we present a model for identifying the best-case design and operation schedule for systems that deliver recycled water to underutilized stormwater spreading basins. Resulting systems are optimal with respect to life cycle costs and water deliveries. Through a case study of Los Angeles, California, we illustrate how delivering recycled water to spreading basins could be optimally implemented. Results illustrate trade-offs between centralized and decentralized configurations. For example, while a centralized Hyperion system could deliver more recycled water to the Hansen Spreading Grounds, this system incurs approximately twice the conveyance cost of a decentralized Tillman system (mean of 44% vs 22% of unit life cycle costs). Compared to existing methods, our model allows for more comprehensive and precise analyses of cost, water volume, and energy trade-offs among different design scenarios. This model can inform decisions about spreading basin operation policies and the development of new water supplies.

Using science and psychology to improve the dissemination and evaluation of scientific work

PubMed Central

Buttliere, Brett T.

2014-01-01

Here I outline some of what science can tell us about the problems in psychological publishing and how to best address those problems. First, the motivation behind questionable research practices is examined (the desire to get ahead or, at least, not fall behind). Next, behavior modification strategies are discussed, pointing out that reward works better than punishment. Humans are utility seekers and the implementation of current change initiatives is hindered by high initial buy-in costs and insufficient expected utility. Open science tools interested in improving science should team up, to increase utility while lowering the cost and risk associated with engagement. The best way to realign individual and group motives will probably be to create one, centralized, easy to use, platform, with a profile, a feed of targeted science stories based upon previous system interaction, a sophisticated (public) discussion section, and impact metrics which use the associated data. These measures encourage high quality review and other prosocial activities while inhibiting self-serving behavior. Some advantages of centrally digitizing communications are outlined, including ways the data could be used to improve the peer review process. Most generally, it seems that decisions about change design and implementation should be theory and data driven. PMID:25191261

Minima de L'intégrale D'action du Problème Newtoniende 4 Corps de Masses Égales Dans R3: Orbites `Hip-Hop'

NASA Astrophysics Data System (ADS)

Chenciner, Alain; Venturelli, Andrea

2000-09-01

We consider the problem of 4 bodies of equal masses in R 3 for the Newtonian r-1 potential. We address the question of the absolute minima of the action integral among (anti)symmetric loops of class H 1 whose period is fixed. It is the simplest case for which the results of [4] (corrected in [5]) do not apply: the minima cannot be the relative equilibria whose configuration is an absolute minimum of the potential among the configurations having a given moment of inertia with respect to their center of mass. This is because the regular tetrahedron cannot have a relative equilibrium motion in R 3 (see [2]). We show that the absolute minima of the action are not homographic motions. We also show that if we force the configuration to admit a certain type of symmetry of order 4, the absolute minimum is a collisionless orbit whose configuration ‘hesitates’ between the central configuration of the square and the one of the tetrahedron. We call these orbits ‘hip-hop’. A similar result holds in case of a symmetry of order 3 where the central configuration of the equilateral triangle with a body at the center of mass replaces the square.

A Patient-centered Approach to Evaluate the Information Needs of Women With Ductal Carcinoma In Situ.

PubMed

Lo, Andrea C; Olson, Robert; Feldman-Stewart, Deb; Truong, Pauline T; Aquino-Parsons, Christina; Bottorff, Joan L; Carolan, Hannah

2017-12-01

To evaluate the information needs of ductal carcinoma in situ (DCIS) patients. Four focus groups involving 24 previously treated DCIS patients were conducted to develop a comprehensive list of questions they felt were important to have answered at the time of diagnosis. Using a survey, a separate group of patients treated for DCIS then rated the importance of having each of these questions addressed before treatment decision making. Response options were "essential," "desired," "not important," "no opinion," and "avoid." For each essential/desired question, respondents specified how addressing it would help them: "understand," "decide," "plan," "not sure," or "other." Focus group participants generated 117 questions used in the survey. Fifty-seven patients completed the survey (55% response rate). Respondents rated a median of 66 questions as essential. The most commonly cited reason for rating a question essential was to "understand," followed by to "decide." The top questions women deemed essential to help them understand were disease specific, whereas the top questions deemed essential to help women decide were predominantly treatment specific, pertaining to available options, recurrence and survival outcomes, and timelines to decide and start treatment. DCIS patients want a large number of questions answered, mostly for understanding, and also for deciding and planning. A core set of questions that most patients consider essential for decision making has been formulated and may be used in the clinical setting and in research to develop educational resources and decision-making tools specific to DCIS.

Governance in Afghanistan: Context and Possibilities

DTIC Science & Technology

2011-05-19

Nathaniel. Russia in Central Asia in 1889 & the Anglo-Russian Question. London: Longmans, Green , and Co., 1889. Drage, Geoffrey. Russian Affairs. New York...Richard Bentley, 1839. Gray, John Alfred. At the Court of the Amir of Afghanistan. New York: Kegan Paul, 2002. Holdich, T. Hungerford. Through Central

CENTRAL FOOD STORE FACILITIES FOR COLLEGES AND UNIVERSITIES.

ERIC Educational Resources Information Center

BLOOMFIELD, BYRON C.

INSPECTION OF A NUMBER OF INSTALLATIONS WAS ORIENTED TOWARD ARCHITECTURAL AND PLANNING QUESTIONS INVOLVING ECONOMICS AND SERVICES OF CENTRAL FOOD STORE FACILITIES. COMMENCING WITH THE PURCHASING PHILOSOPHY WHICH OVERVIEWS THE ORGANIZATION OF FOODS PURCHASING, SELECTION OF PERSONNEL, SPECIFICATIONS FOR PURCHASING, TECHNIQUES FOR PURCHASING, AND…

Highway construction cost comparison survey : final report

DOT National Transportation Integrated Search

2002-04-01

Over the past few years the Washington State Department of Transportation (WSDOT) has been asked numerous questions related to the cost of highway construction in Washington State as compared to other states. In order to address these questions, WSDO...

Legal Challenges and Pitfalls for Start-up Companies - 48 Common Questions and Answers.

PubMed

Staehelin, Matthias

2014-12-01

Transforming a business idea into reality requires a legal implementation plan. The following 48 questions and answers address key issues that typically arise in start-up situations. Early planning can help avoid costly mistakes.

The Big Science Questions About Mercury's Ice-Bearing Polar Deposits After MESSENGER

NASA Astrophysics Data System (ADS)

Chabot, N. L.; Lawrence, D. J.

2018-05-01

Mercury’s polar deposits provide many well-characterized locations that are known to have large expanses of exposed water ice and/or other volatile materials — presenting unique opportunities to address fundamental science questions.

PREDICTION OF NONLINEAR SPATIAL FUNCTIONALS. (R827257)

EPA Science Inventory

Spatial statistical methodology can be useful in the arena of environmental regulation. Some regulatory questions may be addressed by predicting linear functionals of the underlying signal, but other questions may require the prediction of nonlinear functionals of the signal. ...

A decadal view of biodiversity informatics: challenges and priorities

PubMed Central

2013-01-01

Biodiversity informatics plays a central enabling role in the research community's efforts to address scientific conservation and sustainability issues. Great strides have been made in the past decade establishing a framework for sharing data, where taxonomy and systematics has been perceived as the most prominent discipline involved. To some extent this is inevitable, given the use of species names as the pivot around which information is organised. To address the urgent questions around conservation, land-use, environmental change, sustainability, food security and ecosystem services that are facing Governments worldwide, we need to understand how the ecosystem works. So, we need a systems approach to understanding biodiversity that moves significantly beyond taxonomy and species observations. Such an approach needs to look at the whole system to address species interactions, both with their environment and with other species. It is clear that some barriers to progress are sociological, basically persuading people to use the technological solutions that are already available. This is best addressed by developing more effective systems that deliver immediate benefit to the user, hiding the majority of the technology behind simple user interfaces. An infrastructure should be a space in which activities take place and, as such, should be effectively invisible. This community consultation paper positions the role of biodiversity informatics, for the next decade, presenting the actions needed to link the various biodiversity infrastructures invisibly and to facilitate understanding that can support both business and policy-makers. The community considers the goal in biodiversity informatics to be full integration of the biodiversity research community, including citizens’ science, through a commonly-shared, sustainable e-infrastructure across all sub-disciplines that reliably serves science and society alike. PMID:23587026

Understanding and Addressing Vulnerability Following the 2010 Haiti Earthquake: Applying a Feminist Lens to Examine Perspectives of Haitian and Expatriate Health Care Providers and Decision-Makers.

PubMed

Durocher, Evelyne; Chung, Ryoa; Rochon, Christiane; Hunt, Matthew

2016-07-01

Vulnerability is a central concept in humanitarian aid. Discussions of vulnerability in disaster response literature and guidelines for humanitarian aid range from considerations of a universal human vulnerability, to more nuanced examinations of how particular characteristics render individuals more or less at risk. Despite its frequent use, there is a lack of clarity about how vulnerability is conceptualized and how it informs operational priorities in humanitarian assistance. Guided by interpretive description methodology, we draw on the feminist taxonomy of vulnerability presented by Mackenzie, Rogers and Dodds (2014) to examine perspectives of 24 expatriate and Haitian decision-makers and health professionals interviewed between May 2012 and March 2013. The analysis explores concepts of vulnerability and equity in relation to the humanitarian response following the 2010 earthquake in Haiti. Participants' conceptualizations of vulnerability included consideration for inherent vulnerabilities related to individual characteristics (e.g. being a woman or disabled) and situational vulnerabilities related to particular circumstances such as having less access to health care resources or basic necessities. Participants recognized that vulnerabilities could be exacerbated by socio-political structures but felt ill-equipped to address these. The use of the taxonomy and a set of questions inspired by Hurst's (2008) approach to identifying and reducing vulnerability can guide the analysis of varied sources of vulnerability and open discussions about how and by whom vulnerabilities should be addressed in humanitarian responses. More research is required to inform how humanitarian responders could balance addressing acute vulnerability with consideration of systemic and pre-existing circumstances that underlie much of the vulnerability experienced following an acute disaster.

Understanding and Addressing Vulnerability Following the 2010 Haiti Earthquake: Applying a Feminist Lens to Examine Perspectives of Haitian and Expatriate Health Care Providers and Decision-Makers

PubMed Central

Chung, Ryoa; Rochon, Christiane; Hunt, Matthew

2016-01-01

Vulnerability is a central concept in humanitarian aid. Discussions of vulnerability in disaster response literature and guidelines for humanitarian aid range from considerations of a universal human vulnerability, to more nuanced examinations of how particular characteristics render individuals more or less at risk. Despite its frequent use, there is a lack of clarity about how vulnerability is conceptualized and how it informs operational priorities in humanitarian assistance. Guided by interpretive description methodology, we draw on the feminist taxonomy of vulnerability presented by Mackenzie, Rogers and Dodds (2014) to examine perspectives of 24 expatriate and Haitian decision-makers and health professionals interviewed between May 2012 and March 2013. The analysis explores concepts of vulnerability and equity in relation to the humanitarian response following the 2010 earthquake in Haiti. Participants’ conceptualizations of vulnerability included consideration for inherent vulnerabilities related to individual characteristics (e.g. being a woman or disabled) and situational vulnerabilities related to particular circumstances such as having less access to health care resources or basic necessities. Participants recognized that vulnerabilities could be exacerbated by socio-political structures but felt ill-equipped to address these. The use of the taxonomy and a set of questions inspired by Hurst’s (2008) approach to identifying and reducing vulnerability can guide the analysis of varied sources of vulnerability and open discussions about how and by whom vulnerabilities should be addressed in humanitarian responses. More research is required to inform how humanitarian responders could balance addressing acute vulnerability with consideration of systemic and pre-existing circumstances that underlie much of the vulnerability experienced following an acute disaster. PMID:27617037

A decadal view of biodiversity informatics: challenges and priorities.

PubMed

Hardisty, Alex; Roberts, Dave; Addink, Wouter; Aelterman, Bart; Agosti, Donat; Amaral-Zettler, Linda; Ariño, Arturo H; Arvanitidis, Christos; Backeljau, Thierry; Bailly, Nicolas; Belbin, Lee; Berendsohn, Walter; Bertrand, Nic; Caithness, Neil; Campbell, David; Cochrane, Guy; Conruyt, Noël; Culham, Alastair; Damgaard, Christian; Davies, Neil; Fady, Bruno; Faulwetter, Sarah; Feest, Alan; Field, Dawn; Garnier, Eric; Geser, Guntram; Gilbert, Jack; Grosche; Grosser, David; Hardisty, Alex; Herbinet, Bénédicte; Hobern, Donald; Jones, Andrew; de Jong, Yde; King, David; Knapp, Sandra; Koivula, Hanna; Los, Wouter; Meyer, Chris; Morris, Robert A; Morrison, Norman; Morse, David; Obst, Matthias; Pafilis, Evagelos; Page, Larry M; Page, Roderic; Pape, Thomas; Parr, Cynthia; Paton, Alan; Patterson, David; Paymal, Elisabeth; Penev, Lyubomir; Pollet, Marc; Pyle, Richard; von Raab-Straube, Eckhard; Robert, Vincent; Roberts, Dave; Robertson, Tim; Rovellotti, Olivier; Saarenmaa, Hannu; Schalk, Peter; Schaminee, Joop; Schofield, Paul; Sier, Andy; Sierra, Soraya; Smith, Vince; van Spronsen, Edwin; Thornton-Wood, Simon; van Tienderen, Peter; van Tol, Jan; Tuama, Éamonn Ó; Uetz, Peter; Vaas, Lea; Vignes Lebbe, Régine; Vision, Todd; Vu, Duong; De Wever, Aaike; White, Richard; Willis, Kathy; Young, Fiona

2013-04-15

Biodiversity informatics plays a central enabling role in the research community's efforts to address scientific conservation and sustainability issues. Great strides have been made in the past decade establishing a framework for sharing data, where taxonomy and systematics has been perceived as the most prominent discipline involved. To some extent this is inevitable, given the use of species names as the pivot around which information is organised. To address the urgent questions around conservation, land-use, environmental change, sustainability, food security and ecosystem services that are facing Governments worldwide, we need to understand how the ecosystem works. So, we need a systems approach to understanding biodiversity that moves significantly beyond taxonomy and species observations. Such an approach needs to look at the whole system to address species interactions, both with their environment and with other species.It is clear that some barriers to progress are sociological, basically persuading people to use the technological solutions that are already available. This is best addressed by developing more effective systems that deliver immediate benefit to the user, hiding the majority of the technology behind simple user interfaces. An infrastructure should be a space in which activities take place and, as such, should be effectively invisible.This community consultation paper positions the role of biodiversity informatics, for the next decade, presenting the actions needed to link the various biodiversity infrastructures invisibly and to facilitate understanding that can support both business and policy-makers. The community considers the goal in biodiversity informatics to be full integration of the biodiversity research community, including citizens' science, through a commonly-shared, sustainable e-infrastructure across all sub-disciplines that reliably serves science and society alike.

Backward Dependencies and in-Situ wh-Questions as Test Cases on How to Approach Experimental Linguistics Research That Pursues Theoretical Linguistics Questions

PubMed Central

Pablos, Leticia; Doetjes, Jenny; Cheng, Lisa L.-S.

2018-01-01

The empirical study of language is a young field in contemporary linguistics. This being the case, and following a natural development process, the field is currently at a stage where different research methods and experimental approaches are being put into question in terms of their validity. Without pretending to provide an answer with respect to the best way to conduct linguistics related experimental research, in this article we aim at examining the process that researchers follow in the design and implementation of experimental linguistics research with a goal to validate specific theoretical linguistic analyses. First, we discuss the general challenges that experimental work faces in finding a compromise between addressing theoretically relevant questions and being able to implement these questions in a specific controlled experimental paradigm. We discuss the Granularity Mismatch Problem (Poeppel and Embick, 2005) which addresses the challenges that research that is trying to bridge the representations and computations of language and their psycholinguistic/neurolinguistic evidence faces, and the basic assumptions that interdisciplinary research needs to consider due to the different conceptual granularity of the objects under study. To illustrate the practical implications of the points addressed, we compare two approaches to perform linguistic experimental research by reviewing a number of our own studies strongly grounded on theoretically informed questions. First, we show how linguistic phenomena similar at a conceptual level can be tested within the same language using measurement of event-related potentials (ERP) by discussing results from two ERP experiments on the processing of long-distance backward dependencies that involve coreference and negative polarity items respectively in Dutch. Second, we examine how the same linguistic phenomenon can be tested in different languages using reading time measures by discussing the outcome of four self-paced reading experiments on the processing of in-situ wh-questions in Mandarin Chinese and French. Finally, we review the implications that our findings have for the specific theoretical linguistics questions that we originally aimed to address. We conclude with an overview of the general insights that can be gained from the role of structural hierarchy and grammatical constraints in processing and the existing limitations on the generalization of results. PMID:29375417

Backward Dependencies and in-Situ wh-Questions as Test Cases on How to Approach Experimental Linguistics Research That Pursues Theoretical Linguistics Questions.

PubMed

Pablos, Leticia; Doetjes, Jenny; Cheng, Lisa L-S

2017-01-01

The empirical study of language is a young field in contemporary linguistics. This being the case, and following a natural development process, the field is currently at a stage where different research methods and experimental approaches are being put into question in terms of their validity. Without pretending to provide an answer with respect to the best way to conduct linguistics related experimental research, in this article we aim at examining the process that researchers follow in the design and implementation of experimental linguistics research with a goal to validate specific theoretical linguistic analyses. First, we discuss the general challenges that experimental work faces in finding a compromise between addressing theoretically relevant questions and being able to implement these questions in a specific controlled experimental paradigm. We discuss the Granularity Mismatch Problem (Poeppel and Embick, 2005) which addresses the challenges that research that is trying to bridge the representations and computations of language and their psycholinguistic/neurolinguistic evidence faces, and the basic assumptions that interdisciplinary research needs to consider due to the different conceptual granularity of the objects under study. To illustrate the practical implications of the points addressed, we compare two approaches to perform linguistic experimental research by reviewing a number of our own studies strongly grounded on theoretically informed questions. First, we show how linguistic phenomena similar at a conceptual level can be tested within the same language using measurement of event-related potentials (ERP) by discussing results from two ERP experiments on the processing of long-distance backward dependencies that involve coreference and negative polarity items respectively in Dutch. Second, we examine how the same linguistic phenomenon can be tested in different languages using reading time measures by discussing the outcome of four self-paced reading experiments on the processing of in-situ wh -questions in Mandarin Chinese and French. Finally, we review the implications that our findings have for the specific theoretical linguistics questions that we originally aimed to address. We conclude with an overview of the general insights that can be gained from the role of structural hierarchy and grammatical constraints in processing and the existing limitations on the generalization of results.

Four not six: Revealing culturally common facial expressions of emotion.

PubMed

Jack, Rachael E; Sun, Wei; Delis, Ioannis; Garrod, Oliver G B; Schyns, Philippe G

2016-06-01

As a highly social species, humans generate complex facial expressions to communicate a diverse range of emotions. Since Darwin's work, identifying among these complex patterns which are common across cultures and which are culture-specific has remained a central question in psychology, anthropology, philosophy, and more recently machine vision and social robotics. Classic approaches to addressing this question typically tested the cross-cultural recognition of theoretically motivated facial expressions representing 6 emotions, and reported universality. Yet, variable recognition accuracy across cultures suggests a narrower cross-cultural communication supported by sets of simpler expressive patterns embedded in more complex facial expressions. We explore this hypothesis by modeling the facial expressions of over 60 emotions across 2 cultures, and segregating out the latent expressive patterns. Using a multidisciplinary approach, we first map the conceptual organization of a broad spectrum of emotion words by building semantic networks in 2 cultures. For each emotion word in each culture, we then model and validate its corresponding dynamic facial expression, producing over 60 culturally valid facial expression models. We then apply to the pooled models a multivariate data reduction technique, revealing 4 latent and culturally common facial expression patterns that each communicates specific combinations of valence, arousal, and dominance. We then reveal the face movements that accentuate each latent expressive pattern to create complex facial expressions. Our data questions the widely held view that 6 facial expression patterns are universal, instead suggesting 4 latent expressive patterns with direct implications for emotion communication, social psychology, cognitive neuroscience, and social robotics. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Teaching Positions: Difference, Pedagogy, and the Power of Address.

ERIC Educational Resources Information Center

Ellsworth, Elizabeth

This collection of essays takes the question of pedagogy into a variety of places, including film studies, psychoanalytic literature criticism, dialog, and readings of educational documentary films and web sites. Part 1, "Teaching as a Scene of Address," includes chapters 1-6. The chapters introduce the concept of mode of address and…

The Terra Data Fusion Project: An Update

NASA Astrophysics Data System (ADS)

Di Girolamo, L.; Bansal, S.; Butler, M.; Fu, D.; Gao, Y.; Lee, H. J.; Liu, Y.; Lo, Y. L.; Raila, D.; Turner, K.; Towns, J.; Wang, S. W.; Yang, K.; Zhao, G.

2017-12-01

Terra is the flagship of NASA's Earth Observing System. Launched in 1999, Terra's five instruments continue to gather data that enable scientists to address fundamental Earth science questions. By design, the strength of the Terra mission has always been rooted in its five instruments and the ability to fuse the instrument data together for obtaining greater quality of information for Earth Science compared to individual instruments alone. As the data volume grows and the central Earth Science questions move towards problems requiring decadal-scale data records, the need for data fusion and the ability for scientists to perform large-scale analytics with long records have never been greater. The challenge is particularly acute for Terra, given its growing volume of data (> 1 petabyte), the storage of different instrument data at different archive centers, the different file formats and projection systems employed for different instrument data, and the inadequate cyberinfrastructure for scientists to access and process whole-mission fusion data (including Level 1 data). Sharing newly derived Terra products with the rest of the world also poses challenges. As such, the Terra Data Fusion Project aims to resolve two long-standing problems: 1) How do we efficiently generate and deliver Terra data fusion products? 2) How do we facilitate the use of Terra data fusion products by the community in generating new products and knowledge through national computing facilities, and disseminate these new products and knowledge through national data sharing services? Here, we will provide an update on significant progress made in addressing these problems by working with NASA and leveraging national facilities managed by the National Center for Supercomputing Applications (NCSA). The problems that we faced in deriving and delivering Terra L1B2 basic, reprojected and cloud-element fusion products, such as data transfer, data fusion, processing on different computer architectures, science, and sharing, will be presented with quantitative specifics. Results from several science-specific drivers for Terra fusion products will also be presented. We demonstrate that the Terra Data Fusion Project itself provides an excellent use-case for the community addressing Big Data and cyberinfrastructure problems.

Estimated historical distribution of grassland communities of the Southern Great Plains

USGS Publications Warehouse

Reese, Gordon C.; Manier, Daniel J.; Carr, Natasha B.; Callan, Ramana; Leinwand, Ian I.F.; Assal, Timothy J.; Burris, Lucy; Ignizio, Drew A.

2016-12-07

The purpose of this project was to map the estimated distribution of grassland communities of the Southern Great Plains prior to Euro-American settlement. The Southern Great Plains Rapid Ecoregional Assessment (REA), under the direction of the Bureau of Land Management and the Great Plains Landscape Conservation Cooperative, includes four ecoregions: the High Plains, Central Great Plains, Southwestern Tablelands, and the Nebraska Sand Hills. The REA advisors and stakeholders determined that the mapping accuracy of available national land-cover maps was insufficient in many areas to adequately address management questions for the REA. Based on the recommendation of the REA stakeholders, we estimated the potential historical distribution of 10 grassland communities within the Southern Great Plains project area using data on soils, climate, and vegetation from the Natural Resources Conservation Service (NRCS) including the Soil Survey Geographic Database (SSURGO) and Ecological Site Information System (ESIS). The dominant grassland communities of the Southern Great Plains addressed as conservation elements for the REA area are shortgrass, mixed-grass, and sand prairies. We also mapped tall-grass, mid-grass, northwest mixed-grass, and cool season bunchgrass prairies, saline and foothill grasslands, and semi-desert grassland and steppe. Grassland communities were primarily defined using the annual productivity of dominant species in the ESIS data. The historical grassland community classification was linked to the SSURGO data using vegetation types associated with the predominant component of mapped soil units as defined in the ESIS data. We augmented NRCS data with Landscape Fire and Resource Management Planning Tools (LANDFIRE) Biophysical Settings classifications 1) where NRCS data were unavailable and 2) where fifth-level watersheds intersected the boundary of the High Plains ecoregion in Wyoming. Spatial data representing the estimated historical distribution of grassland communities of the Southern Great Plains are provided as a 30 x 30-meter gridded surface (raster dataset). This information will help to address the priority management questions for grassland communities for the Southern Great Plains REA and can be used to inform other regional-level land management decisions.

Chronic Stress, Drug Use, and Vulnerability to Addiction

PubMed Central

Sinha, Rajita

2009-01-01

Stress is a well-known risk factor in the development of addiction and in addiction relapse vulnerability. A series of population-based and epidemiological studies have identified specific stressors and individual-level variables that are predictive of substance use and abuse. Preclinical research also shows that stress exposure enhances drug self-administration and reinstates drug seeking in drug-experienced animals. The deleterious effects of early life stress, child maltreatment, and accumulated adversity on alterations in the corticotropin releasing factor and hypothalamic-pituitary-adrenal axis (CRF/HPA), the extrahypothalamic CRF, the autonomic arousal, and the central noradrenergic systems are also presented. The effects of these alterations on the corticostriatal-limbic motivational, learning, and adaptation systems that include mesolimbic dopamine, glutamate, and gamma-amino-butyric acid (GABA) pathways are discussed as the underlying pathophysiology associated with stress-related risk of addiction. The effects of regular and chronic drug use on alterations in these stress and motivational systems are also reviewed, with specific attention to the impact of these adaptations on stress regulation, impulse control, and perpetuation of compulsive drug seeking and relapse susceptibility. Finally, research gaps in furthering our understanding of the association between stress and addiction are presented, with the hope that addressing these unanswered questions will significantly influence new prevention and treatment strategies to address vulnerability to addiction. PMID:18991954

Sea ice motions in the Central Arctic pack ice as inferred from AVHRR imagery

NASA Technical Reports Server (NTRS)

Emery, William; Maslanik, James; Fowler, Charles

1995-01-01

Synoptic observations of ice motion in the Arctic Basin are currently limited to those acquired by drifting buoys and, more recently, radar data from ERS-1. Buoys are not uniformly distributed throughout the Arctic, and SAR coverage is currently limited regionally and temporally due to the data volume, swath width, processing requirements, and power needs of the SAR. Additional ice-motion observations that can map ice responses simultaneously over large portions of the Arctic on daily to weekly time intervals are thus needed to augment the SAR and buoys data and to provide an intermediate-scale measure of ice drift suitable for climatological analyses and ice modeling. Principal objectives of this project were to: (1) demonstrate whether sufficient ice features and ice motion existed within the consolidated ice pack to permit motion tracking using AVHRR imagery; (2) determine the limits imposed on AVHRR mapping by cloud cover; and (3) test the applicability of AVHRR-derived motions in studies of ice-atmosphere interactions. Each of these main objectives was addressed. We conclude that AVHRR data, particularly when blended with other available observations, provide a valuable data set for studying sea ice processes. In a follow-on project, we are now extending this work to cover larger areas and to address science questions in more detail.

Toward sustainable environmental quality: Identifying priority research questions for Latin America.

PubMed

Furley, Tatiana Heid; Brodeur, Julie; Silva de Assis, Helena C; Carriquiriborde, Pedro; Chagas, Katia R; Corrales, Jone; Denadai, Marina; Fuchs, Julio; Mascarenhas, Renata; Miglioranza, Karina Sb; Miguez Caramés, Diana Margarita; Navas, José Maria; Nugegoda, Dayanthi; Planes, Estela; Rodriguez-Jorquera, Ignacio Alejandro; Orozco-Medina, Martha; Boxall, Alistair Ba; Rudd, Murray A; Brooks, Bryan W

2018-05-01

The Global Horizon Scanning Project (GHSP) is an innovative initiative that aims to identify important global environmental quality research needs. Here we report 20 key research questions from Latin America (LA). Members of the Society of Environmental Toxicology and Chemistry (SETAC) LA and other scientists from LA were asked to submit research questions that would represent priority needs to address in the region. One hundred questions were received, then partitioned among categories, examined, and some rearranged during a workshop in Buenos Aires, Argentina. Twenty priority research questions were subsequently identified. These research questions included developing, improving, and harmonizing across LA countries methods for 1) identifying contaminants and degradation products in complex matrices (including biota); 2) advancing prediction of contaminant risks and effects in ecosystems, addressing lab-to-field extrapolation challenges, and understanding complexities of multiple stressors (including chemicals and climate change); and 3) improving management and regulatory tools toward achieving sustainable development. Whereas environmental contaminants frequently identified in these key questions were pesticides, pharmaceuticals, endocrine disruptors or modulators, plastics, and nanomaterials, commonly identified environmental challenges were related to agriculture, urban effluents, solid wastes, pulp and paper mills, and natural extraction activities. Several interesting research topics included assessing and preventing pollution impacts on conservation protected areas, integrating environment and health assessments, and developing strategies for identification, substitution, and design of less hazardous chemicals (e.g., green chemistry). Finally, a recurrent research need included developing an understanding of differential sensitivity of regional species and ecosystems to environmental contaminants and other stressors. Addressing these critical questions will support development of long-term strategic research efforts to advance more sustainable environmental quality and protect public health and the environment in LA. Integr Environ Assess Manag 2018;14:344-357. © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

Toward sustainable environmental quality: Identifying priority research questions for Latin America

PubMed Central

Furley, Tatiana Heid; Brodeur, Julie; Silva de Assis, Helena C; Carriquiriborde, Pedro; Chagas, Katia R; Corrales, Jone; Denadai, Marina; Fuchs, Julio; Mascarenhas, Renata; Miglioranza, Karina SB; Miguez Caramés, Diana Margarita; Navas, José Maria; Nugegoda, Dayanthi; Planes, Estela; Rodriguez‐Jorquera, Ignacio Alejandro; Orozco‐Medina, Martha; Boxall, Alistair BA; Rudd, Murray A

2018-01-01

ABSTRACT The Global Horizon Scanning Project (GHSP) is an innovative initiative that aims to identify important global environmental quality research needs. Here we report 20 key research questions from Latin America (LA). Members of the Society of Environmental Toxicology and Chemistry (SETAC) LA and other scientists from LA were asked to submit research questions that would represent priority needs to address in the region. One hundred questions were received, then partitioned among categories, examined, and some rearranged during a workshop in Buenos Aires, Argentina. Twenty priority research questions were subsequently identified. These research questions included developing, improving, and harmonizing across LA countries methods for 1) identifying contaminants and degradation products in complex matrices (including biota); 2) advancing prediction of contaminant risks and effects in ecosystems, addressing lab‐to‐field extrapolation challenges, and understanding complexities of multiple stressors (including chemicals and climate change); and 3) improving management and regulatory tools toward achieving sustainable development. Whereas environmental contaminants frequently identified in these key questions were pesticides, pharmaceuticals, endocrine disruptors or modulators, plastics, and nanomaterials, commonly identified environmental challenges were related to agriculture, urban effluents, solid wastes, pulp and paper mills, and natural extraction activities. Several interesting research topics included assessing and preventing pollution impacts on conservation protected areas, integrating environment and health assessments, and developing strategies for identification, substitution, and design of less hazardous chemicals (e.g., green chemistry). Finally, a recurrent research need included developing an understanding of differential sensitivity of regional species and ecosystems to environmental contaminants and other stressors. Addressing these critical questions will support development of long‐term strategic research efforts to advance more sustainable environmental quality and protect public health and the environment in LA. Integr Environ Assess Manag 2018;14:344–357. © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC) PMID:29469193

25 CFR 217.4 - Referral of questions by the joint managers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Referral of questions by the joint managers. 217.4... DISTRIBUTION CORP. § 217.4 Referral of questions by the joint managers. The business committee and the board of... manager at the address furnished in accordance with § 217.3 of this part. Copies of all such referrals...

Compilation of Agricultural Research, Education, and Extension Questions for Discussion. 104th Congress, 1st Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Agriculture.

This volume compiles and reprints the responses of 37 organizations to a series of questions issued by the House Committee on Agriculture in anticipation of debates concerning the Research Title of the 1995 Farm Bill due for updating and revision. The questions address some of the following topics: the role of the federal government in…

Coping with Dialectical Tensions.

ERIC Educational Resources Information Center

Brockriede, Wayne

This paper discusses some of the central issues involved in philosophizing about rhetoric by raising two primary questions within the context of three traditional branches of philosophy: ontology, axiology, and epistemology. The two questions raised are: What are dialectical tensions in a philosophy of rhetoric? and How does a person try to cope…

Response Switching and Self-Efficacy in Peer Instruction Classrooms

ERIC Educational Resources Information Center

Miller, Kelly; Schell, Julie; Ho, Andrew; Lukoff, Brian; Mazur, Eric

2015-01-01

Peer Instruction, a well-known student-centered teaching method, engages students during class through structured, frequent questioning and is often facilitated by classroom response systems. The central feature of any Peer Instruction class is a conceptual question designed to help resolve student misconceptions about subject matter. We provide…

Refocusing--Building a Future for Entrepreneurial Education and Learning

ERIC Educational Resources Information Center

Higgins, David; Galloway, Laura

2014-01-01

The field of entrepreneurship has struggled with fundamental questions concerning the subject's nature and purpose. To whom and to what means are educational and training agendas ultimately directed? Such questions have become of central importance to policy makers, practitioners and academics alike. There are suggestions that university business…

Social Welfare and the Market Economy.

ERIC Educational Resources Information Center

Nelson, Joel I.

1992-01-01

Reports on a study that questions whether private enterprise can maintain quality while reducing costs of providing social welfare services. Reviews three aspects of privatization: (1) competitive markets; (2) rationality; and (3) cost reduction. Concludes by questioning a central claim of economic theory: that free markets and private firms are…

Centralization vs. Decentralization: A Location Analysis Approach for Librarians

ERIC Educational Resources Information Center

Raffel, Jeffrey; Shishko, Robert

1972-01-01

An application of location theory to the question of centralized versus decentralized library facilities for a university, with relevance for special libraries is presented. The analysis provides models for a single library, for two or more libraries, or for decentralized facilities. (6 references) (Author/NH)

Technical report on the potential impacts on business revenues during construction of the central corridor light rail project

DOT National Transportation Integrated Search

2011-02-01

This report investigates the potential impacts to business revenues along the Central Corridor resulting from the construction of the Central Corridor Light Rail Project. This study addresses the potential loss of revenue by local businesses during t...

Rhythm generation, coordination, and initiation in the vocal pathways of male African clawed frogs

PubMed Central

Cavin Barnes, Jessica; Appleby, Todd

2016-01-01

Central pattern generators (CPGs) in the brain stem are considered to underlie vocalizations in many vertebrate species, but the detailed mechanisms underlying how motor rhythms are generated, coordinated, and initiated remain unclear. We addressed these issues using isolated brain preparations of Xenopus laevis from which fictive vocalizations can be elicited. Advertisement calls of male X. laevis that consist of fast and slow trills are generated by vocal CPGs contained in the brain stem. Brain stem central vocal pathways consist of a premotor nucleus [dorsal tegmental area of medulla (DTAM)] and a laryngeal motor nucleus [a homologue of nucleus ambiguus (n.IX-X)] with extensive reciprocal connections between the nuclei. In addition, DTAM receives descending inputs from the extended amygdala. We found that unilateral transection of the projections between DTAM and n.IX-X eliminated premotor fictive fast trill patterns but did not affect fictive slow trills, suggesting that the fast and slow trill CPGs are distinct; the slow trill CPG is contained in n.IX-X, and the fast trill CPG spans DTAM and n.IX-X. Midline transections that eliminated the anterior, posterior, or both commissures caused no change in the temporal structure of fictive calls, but bilateral synchrony was lost, indicating that the vocal CPGs are contained in the lateral halves of the brain stem and that the commissures synchronize the two oscillators. Furthermore, the elimination of the inputs from extended amygdala to DTAM, in addition to the anterior commissure, resulted in autonomous initiation of fictive fast but not slow trills by each hemibrain stem, indicating that the extended amygdala provides a bilateral signal to initiate fast trills. NEW & NOTEWORTHY Central pattern generators (CPGs) are considered to underlie vocalizations in many vertebrate species, but the detailed mechanisms underlying their functions remain unclear. We addressed this question using an isolated brain preparation of African clawed frogs. We discovered that two vocal phases are mediated by anatomically distinct CPGs, that there are a pair of CPGs contained in the left and right half of the brain stem, and that mechanisms underlying initiation of the two vocal phases are distinct. PMID:27760822

Sleep Apnea and Cardiovascular Disease: Lessons From Recent Trials and Need for Team Science.

PubMed

Drager, Luciano F; McEvoy, R Doug; Barbe, Ferran; Lorenzi-Filho, Geraldo; Redline, Susan

2017-11-07

Emerging research highlights the complex interrelationships between sleep-disordered breathing and cardiovascular disease, presenting clinical and research opportunities as well as challenges. Patients presenting to cardiology clinics have a high prevalence of obstructive and central sleep apnea associated with Cheyne-Stokes respiration. Multiple mechanisms have been identified by which sleep disturbances adversely affect cardiovascular structure and function. Epidemiological research indicates that obstructive sleep apnea is associated with increases in the incidence and progression of coronary heart disease, heart failure, stroke, and atrial fibrillation. Central sleep apnea associated with Cheyne-Stokes respiration predicts incident heart failure and atrial fibrillation; among patients with heart failure, it strongly predicts mortality. Thus, a strong literature provides the mechanistic and empirical bases for considering obstructive sleep apnea and central sleep apnea associated with Cheyne-Stokes respiration as potentially modifiable risk factors for cardiovascular disease. Data from small trials provide evidence that treatment of obstructive sleep apnea with continuous positive airway pressure improves not only patient-reported outcomes such as sleepiness, quality of life, and mood but also intermediate cardiovascular end points such as blood pressure, cardiac ejection fraction, vascular parameters, and arrhythmias. However, data from large-scale randomized controlled trials do not currently support a role for positive pressure therapies for reducing cardiovascular mortality. The results of 2 recent large randomized controlled trials, published in 2015 and 2016, raise questions about the effectiveness of pressure therapies in reducing clinical end points, although 1 trial supported the beneficial effect of continuous positive airway pressure on quality of life, mood, and work absenteeism. This review provides a contextual framework for interpreting the results of recent studies, key clinical messages, and suggestions for future sleep and cardiovascular research, which include further consideration of individual risk factors, use of existing and new multimodality therapies that also address adherence, and implementation of trials that are sufficiently powered to target end points and to support subgroup analyses. These goals may best be addressed through strengthening collaboration among the cardiology, sleep medicine, and clinical trial communities. © 2017 American Heart Association, Inc.

Impact of scaffolding and question structure on the gender gap

NASA Astrophysics Data System (ADS)

Dawkins, Hillary; Hedgeland, Holly; Jordan, Sally

2017-12-01

We address previous hypotheses about possible factors influencing the gender gap in attainment in physics. Specifically, previous studies claim that scaffolding may preferentially benefit female students, and we present some alternative conclusions surrounding this hypothesis. By taking both student attainment level and the degree of question scaffolding into account, we identify questions that exhibit real bias in favor of male students. We find that both multidimensional context and use of diagrams are common elements of such questions.

UAS Integration into the NAS: Detect and Avoid Display Evaluations in Support of SC-228 MOPS Development

NASA Technical Reports Server (NTRS)

Fern, Lisa; Rorie, Conrad; Shively, Jay

2016-01-01

At the May 2015 SC-228 meeting, requirements for TCAS II interoperability became elevated in priority. A TCAS interoperability work group was formed to identify and address key issuesquestions. The TCAS work group came up with an initial list of questions and a plan to address those questions. As part of that plan, NASA proposed to run a mini HITL to address display, alerting and guidance issues. A TCAS Interoperability Workshop was held to determine potential displayalertingguidance issues that could be explored in future NASA mini HITLS. Consensus on main functionality of DAA guidance when TCAS II RA occurs. Prioritized list of independent variables for experimental design. Set of use cases to stress TCAS Interoperability.

Genetics Education in Nurse Residency Programs: A Natural Fit.

PubMed

Hamilton, Nalo M; Stenman, Christina W; Sang, Elaine; Palmer, Christina

2017-08-01

Scientific advances are shedding light on the genetic underpinning of common diseases. With such insight, the entire health care team is faced with the need to address patient questions regarding genetic risk, testing, and the psychosocial aspects of genetics information. Nurses are in a prime position to help with patient education about genetic conditions, yet they often lack adequate genetics education within their nursing curriculum to address patient questions and provide resources. One mechanism to address this knowledge deficit is the incorporation of a genetics-based curriculum into nurse residency programs. This article describes a novel genetics-based curriculum designed and implemented in the UCLA Health System Nurse Residency Program. J Contin Educ Nurs. 2017;48(8):379-384. Copyright 2017, SLACK Incorporated.

Fighting blindness with microelectronics.

PubMed

Zrenner, Eberhart

2013-11-06

There is no approved cure for blindness caused by degeneration of the photoreceptor cells of the retina. However, there has been encouraging progress with attempts to restore vision using microelectronic retinal implant devices. Yet many questions remain to be addressed. Where is the best location to implant multielectrode arrays? How can spatial and temporal resolution be improved? What are the best ways to ensure the safety and longevity of these devices? Will color vision be possible? This Perspective discusses the current state of the art of retinal implants and attempts to address some of the outstanding questions.

Tracing Radical Working-Class Education: Praxis and Historical Representation

ERIC Educational Resources Information Center

Gerrard, Jessica

2012-01-01

Growing collections of social and educational history chronicle the many instances of educational agency that lie outside institutional narratives. Renewing and developing historical understanding, these histories raise important methodological questions surrounding historical representation. Addressing such questions, this paper develops the…

Frequently Asked Questions from EPA's Community Air Monitoring Training Event, July 2015

EPA Pesticide Factsheets

EPA's Community Air Monitoring Training Event on July 9, 2015 in RTP, NC. Forty citizen scientists attended in person while over 500 others attended the live webinar. Several attendees posted questions, which EPA scientists have addressed here.

Opportunities and questions for the fundamental biological sciences in space

NASA Technical Reports Server (NTRS)

Sharp, Joseph C.; Vernikos, Joan

1993-01-01

With the advent of sophisticated space facilities we discuss the overall nature of some biological questions that can be addressed. We point out the need for broad participation by the biological community, the necessary facilities, and some unique requirements.

Improving Explanatory Inferences from Assessments

ERIC Educational Resources Information Center

Diakow, Ronli Phyllis

2013-01-01

This dissertation comprises three papers that propose, discuss, and illustrate models to make improved inferences about research questions regarding student achievement in education. Addressing the types of questions common in educational research today requires three different "extensions" to traditional educational assessment: (1)…

Experimental philosophy.

PubMed

Knobe, Joshua; Buckwalter, Wesley; Nichols, Shaun; Robbins, Philip; Sarkissian, Hagop; Sommers, Tamler

2012-01-01

Experimental philosophy is a new interdisciplinary field that uses methods normally associated with psychology to investigate questions normally associated with philosophy. The present review focuses on research in experimental philosophy on four central questions. First, why is it that people's moral judgments appear to influence their intuitions about seemingly nonmoral questions? Second, do people think that moral questions have objective answers, or do they see morality as fundamentally relative? Third, do people believe in free will, and do they see free will as compatible with determinism? Fourth, how do people determine whether an entity is conscious?

Children's questions about interparent conflict and violence: what's a mother to say?

PubMed

McDonald, Renee; Jouriles, Ernest N; Rosenfield, David; Leahy, Matthew M

2012-02-01

This research examined the relation between mothers' responses to children's questions about interparent conflict and children's adjustment. Participants were 134 mothers and their children (70 boys, 64 girls), aged 7 to 10. In each family, an act of intimate-partner violence (IPV) had recently occurred. Mothers' responses to children's questions about interparent conflict were assessed via a semistructured interview coded to reflect the extent to which the mothers' responses addressed the content of the children's questions. Mothers and children reported on physical IPV. Mothers also reported on interparent conflict, parent-child aggression, and maternal warmth. Children's adjustment was assessed via mothers' and children's reports at two time points 6 months apart. The extent to which mothers' responses addressed the content of the children's questions about interparent conflict was negatively associated with children's adjustment problems, after accounting for the frequency of physical IPV, frequency of interparent conflict, parent-child aggression, and maternal warmth. These associations emerged cross-sectionally and prospectively. However, in those prospective analyses that accounted for children's baseline levels of adjustment, maternal responsiveness was not associated with later children's adjustment problems.

Randomized controlled trials in evidence-based mental health care: getting the right answer to the right question.

PubMed

Essock, Susan M; Drake, Robert E; Frank, Richard G; McGuire, Thomas G

2003-01-01

The purpose of clinical research is to answer this question: Would a new treatment, when added to the existing range of treatment options available in practice, help patients? Randomized controlled trials (RCTs)--in particular, double-blind RCTs--have important methodological advantages over observational studies for addressing this question. These advantages, however, come at a price. RCTs compare treatments using a particular allocation rule for assigning patients to treatments (random assignment) that does not mimic real-world practice. "Favorable" results from an RCT indicating that a new treatment is superior to existing treatments are neither necessary nor sufficient for establishing a "yes" answer to the question posed above. Modeled on an experimental design, RCTs are expensive in time and money and must compare simple differences in treatments. Findings have a high internal validity but may not address the needs of the field, particularly where treatment is complex and rapidly evolving. Design of clinical research needs to take account of the way treatments are allocated in actual practice and include flexible designs to answer important questions most effectively.

Development of the Central Dogma Concept Inventory (CDCI) Assessment Tool

PubMed Central

Newman, Dina L.; Snyder, Christopher W.; Fisk, J. Nick; Wright, L. Kate

2016-01-01

Scientific teaching requires scientifically constructed, field-tested instruments to accurately evaluate student thinking and gauge teacher effectiveness. We have developed a 23-question, multiple select–format assessment of student understanding of the essential concepts of the central dogma of molecular biology that is appropriate for all levels of undergraduate biology. Questions for the Central Dogma Concept Inventory (CDCI) tool were developed and iteratively revised based on student language and review by experts. The ability of the CDCI to discriminate between levels of understanding of the central dogma is supported by field testing (N = 54), and large-scale beta testing (N = 1733). Performance on the assessment increased with experience in biology; scores covered a broad range and showed no ceiling effect, even with senior biology majors, and pre/posttesting of a single class focused on the central dogma showed significant improvement. The multiple-select format reduces the chances of correct answers by random guessing, allows students at different levels to exhibit the extent of their knowledge, and provides deeper insight into the complexity of student thinking on each theme. To date, the CDCI is the first tool dedicated to measuring student thinking about the central dogma of molecular biology, and version 5 is ready to use. PMID:27055775

Patient satisfaction with community pharmacy: comparing urban and suburban chain-pharmacy populations.

PubMed

Malewski, David F; Ream, Aimrie; Gaither, Caroline A

2015-01-01

Patient satisfaction with pharmaceutical care can be a strong predictor of medication and other health-related outcomes. Less understood is the role that location of pharmacies in urban or suburban environments plays in patient satisfaction with pharmacy and pharmacist services. The purpose of this study was to serve as a pilot examining urban and suburban community pharmacy populations for similarities and differences in patient satisfaction. Community pharmacy patients were asked to self-administer a 30-question patient satisfaction survey. Fifteen questions addressed their relationship with the pharmacist, 10 questions addressed satisfaction and accessibility of the pharmacy, and five questions addressed financial concerns. Five urban and five suburban pharmacies agreed to participate. Data analysis included descriptive statistics and chi-square analysis. Most patients reported high levels of satisfaction. Satisfaction with pharmacist relationship and service was 70% or higher with no significant differences between locations. There were significant differences between the urban and suburban patients regarding accessibility of pharmacy services, customer service and some patient/pharmacist trust issues. The significant differences between patient satisfaction in the suburban and urban populations warrant a larger study with more community pharmacies in other urban, suburban and rural locations to better understand and validate study findings. Copyright © 2015 Elsevier Inc. All rights reserved.

Centrally managed unified shared virtual address space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkes, John

Systems, apparatuses, and methods for managing a unified shared virtual address space. A host may execute system software and manage a plurality of nodes coupled to the host. The host may send work tasks to the nodes, and for each node, the host may externally manage the node's view of the system's virtual address space. Each node may have a central processing unit (CPU) style memory management unit (MMU) with an internal translation lookaside buffer (TLB). In one embodiment, the host may be coupled to a given node via an input/output memory management unit (IOMMU) interface, where the IOMMU frontendmore » interface shares the TLB with the given node's MMU. In another embodiment, the host may control the given node's view of virtual address space via memory-mapped control registers.« less

On Deciding How to Decide: To Centralize or Decentralize.

ERIC Educational Resources Information Center

Chaffee, Ellen Earle

Issues concerning whether to centralize or decentralize decision-making are addressed, with applications for colleges. Centralization/decentralization (C/D) must be analyzed with reference to a particular decision. Three components of C/D are locus of authority, breadth of participation, and relative contribution by the decision-maker's staff. C/D…

A Massive Central Peak and a Low Peak Ring in Gale Crater - Important Influences on the Formation of Mt. Sharp

NASA Technical Reports Server (NTRS)

Allen, Carlton C.

2015-01-01

The Curiosity rover is exploring 155 km diameter Gale crater and Mt. Sharp, Gale's high central mound. This study addresses the central peak and proposed peak ring, and their influence on the overall morphology of the mountain.

Issues with Access to Acquisition Data and Information in the Department of Defense: Policy and Practice

DTIC Science & Technology

2015-01-01

39 C. Central Repository Case Studies...Subject-Matter Experts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 C.1. Comparison of OSD Central Repositories...are also several options to addressing the confusion regarding policy. • OUSD(AT&L) could create and maintain a central , authoritative online resource

Court-Driven Reform and Equal Educational Opportunity: Centralization, Decentralization, and the Shifting Judicial Role

ERIC Educational Resources Information Center

Superfine, Benjamin Michael

2010-01-01

Judicial decisions focusing on equal educational opportunity involve significant issues of educational governance and often involve explicit questions about the extent to which authority to make educational decisions should be centralized or decentralized across various institutions and entities. This review aims at clarifying scholars'…

The Collision of Athletics & Consolidation

ERIC Educational Resources Information Center

Graves, Bill

2010-01-01

For decades, people questioned the sense of having two school districts, each with its own superintendent, central office and high school, operating in the same small town of The Dalles on the banks of the Columbia River in north-central Oregon. But election campaigns to consolidate repeatedly failed because each community had strong emotional…

Development of the Central Dogma Concept Inventory (CDCI) Assessment Tool

ERIC Educational Resources Information Center

Newman, Dina L.; Snyder, Christopher W.; Fisk, J. Nick; Wright, L. Kate

2016-01-01

Scientific teaching requires scientifically constructed, field-tested instruments to accurately evaluate student thinking and gauge teacher effectiveness. We have developed a 23-question, multiple select--format assessment of student understanding of the essential concepts of the central dogma of molecular biology that is appropriate for all…

Viewer Perspective Affects Central Bottleneck Requirements in Spatial Translation Tasks

ERIC Educational Resources Information Center

Franz, Elizabeth A.; Sebastian, Alexandra; Hust, Christina; Norris, Tom

2008-01-01

A psychological refractory period (PRP) approach and the locus of slack logic were applied to examine the novel question of whether spatial translation processes can begin before the central bottleneck when effector or noneffector stimuli are processed from an egocentric (viewer-centered) perspective. In single tasks, trials requiring spatial…

Philosophy of Education in the UK: The Historical and Contemporary Tradition

ERIC Educational Resources Information Center

Oancea, Alis; Bridges, David

2009-01-01

Questions of a philosophical nature are central to every significant debate in the field of educational theory, policy, practice and research. Of all disciplines, philosophy is perhaps the one in which "analysis, argumentation and critique" are given most central, systematic and comprehensive attention. In addition, philosophy is…

Central distractors in Force Concept Inventory data

NASA Astrophysics Data System (ADS)

Scott, Terry F.; Schumayer, Dániel

2018-01-01

The Force Concept Inventory was designed to poll the Newtonian conception of force. While there are many in-depth studies analyzing response data that look at the structure of the correct answers, we believe that the incorrect answers also carry revealing information about the students' worldview. The inventory was originally designed so that the "distractors" in each question reflected commonly held misconceptions, and thus the rate at which students guess the correct answer is very low. Students select incorrect answers that correspond to the misconception that they hold and there are very few responses which appear obviously wrong to students. A side effect of this approach is that the incorrect responses reflect the non-Newtonian worldviews held by students. These non-Newtonian worldviews are coherent and robust, and this, at least in part, helps to explain why these misconceptions are so resistant to instruction. In this study we focus once more on the misconception data in Force Concept Inventory responses, particularly on the linkages between these misconceptions. We hypothesize that there are distinct groupings of distractor items formed by the strength of the association between these items. The two largest groupings are associated with the "impetus" world view in which the motion of an object is determined by the quantity of impetus which that object contains. We find that certain central items hold particularly important places in these groupings and also that individual groupings may be connected to each other by "connector" items. We finally suggest that, on the basis of this study, that these non-Newtonian worldviews might best be dismantled by addressing these key central and connector items.

Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways

PubMed Central

Lee, M. C.; O'Neill, J.; Dickenson, A. H.; Iannetti, G. D.

2016-01-01

Central sensitization (CS), the increased sensitivity of the central nervous system to somatosensory inputs, accounts for secondary hyperalgesia, a typical sign of several painful clinical conditions. Brain potentials elicited by mechanical punctate stimulation using flat-tip probes can provide neural correlates of CS, but their signal-to-noise ratio is limited by poor synchronization of the afferent nociceptive input. Additionally, mechanical punctate stimulation does not activate nociceptors exclusively. In contrast, low-intensity intraepidermal electrical stimulation (IES) allows selective activation of type II Aδ-mechano-heat nociceptors (II-AMHs) and elicits reproducible brain potentials. However, it is unclear whether hyperalgesia from IES occurs and coexists with secondary mechanical punctate hyperalgesia, and whether the magnitude of the electroencephalographic (EEG) responses evoked by IES within the hyperalgesic area is increased. To address these questions, we explored the modulation of the psychophysical and EEG responses to IES by intraepidermal injection of capsaicin in healthy human subjects. We obtained three main results. First, the intensity of the sensation elicited by IES was significantly increased in participants who developed robust mechanical punctate hyperalgesia after capsaicin injection (i.e., responders), indicating that hyperalgesia from IES coexists with punctate mechanical hyperalgesia. Second, the N2 peak magnitude of the EEG responses elicited by IES was significantly increased after the intraepidermal injection of capsaicin in responders only. Third, a receiver-operator characteristics analysis showed that the N2 peak amplitude is clearly predictive of the presence of CS. These findings suggest that the EEG responses elicited by IES reflect secondary hyperalgesia and therefore represent an objective correlate of CS. PMID:27098022

First step to reducing infection risk as a system: evaluation of infection prevention processes for 71 hospitals.

PubMed

Fakih, Mohamad G; Heavens, Michelle; Ratcliffe, Carol J; Hendrich, Ann

2013-11-01

Hospitals can better focus their efforts to prevent health care-associated infections (HAIs) if they identify specific areas for improvement. We administered a 96-question survey to infection preventionists at 71 Ascension Health hospitals to evaluate opportunities for the prevention of catheter-associated urinary tract infection, central line-associated bloodstream infection, ventilator-associated pneumonia, and surgical site infection. Seventy-one (100%) infection preventionists completed the survey. The majority of hospitals had established policies for urinary catheter placement and maintenance (55/70, 78.6%), central venous catheter maintenance (68/71, 95.8%), and care for the mechanically ventilated patient (62/66, 93.9%). However, there was variation in health care worker practice and evaluation of competencies and outcomes. When addressing device need, 55 of 71 (77.5%) hospitals used a nurse-driven evaluation of urinary catheter need, 26 of 71 (36.6%) had a team evaluation for central venous catheters on transfer out of intensive care, and 53 of 57 (93%) assessed daily ventilator support for continued need. Only 19 of 71 (26.8%) hospitals had annual nursing competencies for urinary catheter placement and maintenance, 29 of 71 (40.8%) for nursing venous catheter maintenance, and 38 of 66 (57.6%) for appropriate health care worker surgical scrubbing. We suggest evaluating infection prevention policies and practices as a first step to improvement efforts. The next steps include implementing spread of evidence-based practices, with focus on competencies and feedback on performance. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.

A shared Y-chromosomal heritage between Muslims and Hindus in India.

PubMed

Gutala, Ramana; Carvalho-Silva, Denise R; Jin, Li; Yngvadottir, Bryndis; Avadhanula, Vasanthi; Nanne, Khaja; Singh, Lalji; Chakraborty, Ranajit; Tyler-Smith, Chris

2006-11-01

Arab forces conquered the Indus Delta region in 711 AD: and, although a Muslim state was established there, their influence was barely felt in the rest of South Asia at that time. By the end of the tenth century, Central Asian Muslims moved into India from the northwest and expanded throughout the subcontinent. Muslim communities are now the largest minority religion in India, comprising more than 138 million people in a predominantly Hindu population of over one billion. It is unclear whether the Muslim expansion in India was a purely cultural phenomenon or had a genetic impact on the local population. To address this question from a male perspective, we typed eight microsatellite loci and 16 binary markers from the Y chromosome in 246 Muslims from Andhra Pradesh, and compared them to published data on 4,204 males from East Asia, Central Asia, other parts of India, Sri Lanka, Pakistan, Iran, the Middle East, Turkey, Egypt and Morocco. We find that the Muslim populations in general are genetically closer to their non-Muslim geographical neighbors than to other Muslims in India, and that there is a highly significant correlation between genetics and geography (but not religion). Our findings indicate that, despite the documented practice of marriage between Muslim men and Hindu women, Islamization in India did not involve large-scale replacement of Hindu Y chromosomes. The Muslim expansion in India was predominantly a cultural change and was not accompanied by significant gene flow, as seen in other places, such as China and Central Asia.

Vision and commercial motor vehicle driver safety : vol. 2 : appendix G

DOT National Transportation Integrated Search

2007-12-14

The purpose of this evidence report is to address several key questions posed by the Federal Motor Carrier Safety Administration (FMCSA) that pertain to vision and commercial motor vehicle (CMV) driver safety. Each of these key questions was develope...

The Importance of Geodetically Controlled Data Sets: THEMIS Controlled Mosaics of Mars, a Case Study

NASA Astrophysics Data System (ADS)

Fergason, R. L.; Weller, L.

2018-04-01

Accurate image registration is necessary to answer questions that are key to addressing fundamental questions about our universe. To provide such a foundational product for Mars, we have geodetically controlled and mosaicked THEMIS IR images.